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Beaumaris R N L I Lifeboat assists a broken down Jet Ski.
At the request of H. M Coastguard the volunteer crew members of the R N L I Beaumaris lifeboat launched to the assistance of a jet ski with engine problems on the Menai Strait.
Interested in becoming a crew member?
The charity welcomes people from all walks of life and no previous sea-going experience is needed to join the lifeboat crew. The RNLI provides fantastic training to turn ordinary people into lifesavers. By volunteering with the RNLI people will gain some great experience, knowledge and skills.
Beaumaris RNLI are always looking for new volunteers to help run the lifesaving service. If you are aged 17 or over, physically fit, work or live within 10 minutes of the lifeboat station and eager to join a lifesaving organisation then please come by and say hello.
The volunteers meet every Thursday evenings at 6.00pm for their weekly training exercises.
Notes to editors:
RNLI media
Key facts about the RNLI
The Royal National Lifeboat Institution is the charity that saves lives at sea. Our volunteers provide a 24-hour search and rescue service in the United Kingdom and Ireland from 238 lifeboat stations, including four along the River Thames and inland lifeboat stations at Loch Ness, Lough Derg, Enniskillen, Carrybridge and Lough Ree. Additionally the RNLI has more than 1,000 lifeguards on over 240 beaches around the UK and operates a specialist flood rescue team, which can respond anywhere across the UK and Ireland when inland flooding puts lives at risk.
The RNLI relies on public donations and legacies to maintain its rescue service. As a charity it is separate from, but works alongside, government-controlled and funded coastguard services. Since the RNLI was founded in 1824 our lifeboat crews and lifeguards have saved at least 140,000 lives. Volunteers make up 95% of the charity, including 4,600 volunteer lifeboat crew members and 3,000 volunteer shore crew. Additionally, tens of thousands of other dedicated volunteers raise funds and awareness, give safety advice, and help in our museums, shops and offices.
Learn more about the RNLI
For more information please visit the RNLI website or Facebook, Twitter and YouTube. News releases, videos and photos are available on the News Centre.
Contacting the RNLI - public enquiries
Members of the public may contact the RNLI on 0300 300 9990 or by email.
The RNLI is a charity registered in England and Wales (209603) and Scotland (SC037736). Charity number 20003326 in the Republic of Ireland


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Project Leadership FAQs
From Joomla! Documentation
- 1 What is the Joomla! Community?
- 2 Is the Joomla! community a democracy?
- 3 Why does the core team require a 2/3 vote for major decisions?
- 4 What do the project managers do?
- 5 How are Working Group members added/removed?
- 6 Do the Core Team or Work Group members get paid for working on Joomla!?
- 7 License
- 8 Open Source Matters
- 9 Removal of a Project Member
- 10 Adding Features
What is the Joomla! Community?
Within the context of Free and Open Source Software projects, a community is another way of describing the collective body of individuals that contribute to a project in a positive way. Membership within the community is conditional and is earned through contribution and commitment. The Joomla! community is an amazing group of dedicated, knowledgeable, and highly skilled individuals that give their time and expertise to the project freely, without strings, and without the expectation of reward or reimbursement. Joomla! is a great project because of the contributions that these people make and it would not be the same without these people. They have each earned their place, their voice, and the respect of their peers within the community through their contributions and dedication. The community consists of the Joomla! Core Team, OSM, all the Joomla! Working Group members, as well as many, many other people that have each given a piece of themselves to the project in hope of helping the greater good, of preserving freedoms, of leveling the playing field, and even just to do something fun. We are eternally grateful to all of these people and the things they have contributed to the Joomla! project.
Is the Joomla! community a democracy?
Generally speaking, the Joomla! community is not a democratic organization and it has never presented itself as such. Occasionally, the Core Team asks the community to vote on things as a whole but this tends to be a pretty rare event. However, the community's input and feedback are welcome and carefully listened to.
Why does the core team require a 2/3 vote for major decisions?
Well, we require a 2/3 majority because we prefer to have consensus about motions being put to vote before they are actually voted on. This means, if someone wants to propose a motion, they will initiate a discussion about the issue prior to voting on it. If the discussion looks favorable to their motion, a vote will be started. Having a 2/3 majority also prevents fragmentation within the team. We don't want to have to resort to counting the votes and having 8 in favor and 7 against. If that is the case, there is most likely a problem that has not been discussed thoroughly enough. So, as a team we tend to resemble a consensus democracy more than a straight-up democracy where majority wins.
What do the project managers do?
The Joomla! project managers act as facilitators in order to help ensure that project level tasks are handled in a timely and proper manner. They are not dictators, commanders, or fascists. They are just the poor unfortunate souls that are tasked with handling a lot of work that other people don't want to do.
How are Working Group members added/removed?
The process for adding and removing Working Group members is defined by the Working Group coordinator and because of that it varies from group to group.
Do the Core Team or Work Group members get paid for working on Joomla!?
Nobody is paid by the Joomla! project or OSM to work specifically on Joomla!. All the work we do for the project is done voluntarily without reimbursement. Many members of the Core Team and the Working Groups make money around the Joomla! project by providing services, products, education, consulting, etc.
What license is Joomla! released under?
Joomla! is released under the GNU GPL (Gnu General Public) version 2 or later. Details of the GPL can be found here: http://www.gnu.org/licenses/gpl.html.
What has the copyright of Joomla!?
The Joomla! project does not aggregate the copyrights of its code contributors. No contributor is required to transfer his/her copyright to Joomla! and each individual contribution will forever remain in the ownership of its author. This also applies to translations of the Installation language set as these alone are included in the core release of Joomla!. Open Source Matters Inc., a not-for-profit organisation, holds the Joomla! project's assets and represents Joomla!'s legal matters. Joomla! project claims copyright over the total aggregated creation which is the CMS and framework. This copyright is held by Open Source Matters Inc. This is why each file in the release is marked "Copyright - Open Source Matters Inc." This does not violate the copyright and ownership of the individual contributions. These always remain the authors' property. Attributions of the copyrights of contributors and other included code elements is detailed in the main copyright file in the root directory of the Joomla! installation. As the contributors do not transfer copyright they instead declare that their code contributions are licensed to Open Source Matters Inc. in a limited and non-exclusive fashion. Limited meaning that Open Source Matters Inc. may only use their contribution if it is released under GNU/GPL for the entire Joomla! CMS (or GNU/LGPL in the specific case of the Joomla! Framework Libraries). Non-exclusive meaning that the contributors are free to do whatever they wish with their own creations including using it for their own releases under any licence they wish (including commercial).
Open Source Matters
What is Open Source Matters?
Open Source Matters is a non profit organization that provides financial, legal and organizational support for the Joomla! project. For more information on Open Source Matters, please visit the OSM FAQ http://www.opensourcematters.org/content/view/92/63/.
Who runs Open Source Matters?
OSM is run by a board of directors. You can find out more about the current OSM board members by visiting the Open Source Matters website or by clicking here: http://www.opensourcematters.org/content/blogcategory/37/62/.
Does anyone work for Open Source Matters?
No. Open Source Matters consists exclusively of the board of directors. It has no employees or members. Board members are volunteers.
How are board members appointed or removed?
The board members of OSM are appointed by the "Community Oversight Committee" which is basically a legal name for the Joomla! Core Team. Board members are appointed to a one year term at which point they can resign, be reelected, or be replaced. If an OSM board member is acting inappropriately or in way that may compromise the Joomla! project or OSM, the Community Oversight Committee can hold a vote to remove that member. This action also requires a 2/3 quorum and 2/3 of the votes cast to be in favor of the motion.
Does Open Source Matters run the Joomla! project?
No. The Joomla! Core Team is responsible for managing the project and making sure it continues moving forward. Open Source Matters is intended to be an aide to the Core Team and to assist the Core Team. As such, Open Source Matters serves the project, it does not run the project.
Removal of a Project Member
Why would someone be removed from the Core Team, Working Groups, OSM, Community, Project, etc?
Sometimes, the Joomla! project has to deal with people that are detrimental to the overall health or success of the project. On rare occasions, people need to be removed in part or completely in order to protect the health of the community, the project, or the sanity of its members. There are a few reasons why someone could be removed including: intentionally harming the project, being continuously disruptive, repeatedly violating of the Code of Conduct, etc. We do not take these decisions lightly and we always give several warnings and opportunities to turn around before taking a drastic step such as removal from one of the teams or banning.
Adding Features
Editing How do you request a feature?
You can request a feature on GitHub or on the Production Department Twitter Account

subset: commoncrawl


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KIT (also called CD117) is a receptor tyrosine kinase (RTK) expressed on a wide variety of cell types. The ligand for KIT is stem cell factor (SCF). The binding of SCF to the extracellular domain of KIT induces receptor dimerization and activation of downstream signaling pathways, including the PI3K-AKT-mTOR pathway, the RAS-RAF-MEK-ERK pathway, and the signal transducer and activator of transcription 3 (acute-phase response factor), or STAT3, pathway, all of which are involved in mediating pro-growth and pro-survival signals within the cell (Figure 1).
Mutant KIT has been implicated in the pathogenesis of several cancers including melanoma, acute leukemia, and gastrointestinal stromal tumor (GIST; Heinrich et al. 2003; Hirota et al. 1998).
The discovery of KIT mutations revolutionized the treatment of GISTs. The use of imatinib mesylate (Gleevec), an oral KIT inhibitor leads to rapid, substantial, and durable tumor responses (Demetri et al. 2002). Not all KIT mutations are associated with equal sensitivity to imatinib (Heinrich et al. 2008); some are more sensitive to second-generation KIT inhibitors.
Figure 1. Schematic of KIT signaling pathways. The binding of SCF, to the KIT receptor tyrosine kinase results in activation of the MAPK signaling pathway (RAS-RAF-MEK-ERK), the PI3K pathway (PI3K-AKT-mTOR), and the STAT3 pathway. The letter "K" within the schema denotes the tyrosine kinase domain.
Related Pathways
Suggested Citation: Lovly, C., J. Sosman, W. Pao. 2015. KIT. My Cancer Genome https://www.mycancergenome.org/content/disease/gist/kit/?tab=0 (Updated December 7).
Last Updated: December 7, 2015


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Difference between revisions of "STEM FAQ"
(→What is the STEM project release schedule?)
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If a downloadable RCP version is not available for your platform, you must download the STEM source from CVS and run from the source.
If a downloadable RCP version is not available for your platform, you must download the STEM source from CVS and run from the source.
==What features are new in release 0.3.0a?==
==What features are new in release 0.3.0a?==
Revision as of 14:04, 1 September 2009
- 1 What is the STEM project release schedule?
- 2 What platforms are supported?
- 3 What features are new in release 0.5.0?
- 4 What features are new in release 0.4.0?
- 5 What features are new in release 0.3.0a?
- 6 What are other features are available in STEM?
- 7 What features are planned for future releases?
- 8 Can STEM be used for more than just disease modeling?
- 9 What is the most novel extension to STEM?
- 10 Can STEM be used for "situational awareness"?
What is the STEM project release schedule?
Release 0.5.0 was released on June 14th, 2009, all platforms
Release 0.4.0 was released on January 28th, 2009, all platforms
Release 0.3.0a was released on September 13th, 2008 (Windows only), replacing release 0.3.0 from September 9th, 2008.
Release 0.2.1 became available December 17th, 2007, updating release 0.2.0 dated June 8th, 2007.
These include the current STEM source code and downloadable executables for Windows, Linux and Mac OS X.
What platforms are supported?
In theory, STEM will run on any platform supported by Eclipse. The current downloads are for RCP versions of Windows, Linux, and Mac OSX. Note that Java 1.6 is required for MacOS.
If a downloadable RCP version is not available for your platform, you must download the STEM source from CVS and run from the source.
What features are new in release 0.5.0?
What features are new in release 0.4.0?
What features are new in release 0.3.0a?
- Experiments. An Experiment is a combination of a Scenario and a set of Modifiers. A Modifier is a definition of how to systematically change the value of some element of a Scenario in a specific manner. The intent is to be able to specify how to create a sequence of derivative Scenarios from the base Scenario referenced by the Experiment. These derivative Scenarios are created by applying the Modifiers to the base Scenario. An Experiment can be executed like Scenario creating a Batch which then spawns off separate Simulations from each of the derivative Scenarios. Currently, the Simulations in a Batch are run sequentially. Parallel execution is planned for a future release.
- A preliminary implementation of Triggers (Predicate & Action). A Trigger is a combination of a Boolean Predicate and an Action. At each cycle in the simulation, if the Boolean expression is True, then the Action is "triggered". An action is a "Modifier" and can change arbitrary components of a running simulation including things like the values of labels in the graph (e.g., to close an airport) or the parameters of a disease model. Currently, the predicates are limited to testing the absolute or elapsed time value. This limitation will be removed in a future release.
- Various improvements to the visualizations including display of the graph edges
- A new Analysis Perspective
The Analysis and Validation Perspective is a new STEM Perspective that supports a variety of analysis, fitting, and comparison functions across multiple simulations and data sets.
Model Parameter Estimation View
Given a set of data (SI, SIR, or SEIR) as a function of time, this perspective provides an estimation of the model parameters for a standard compartment model of the corresponding type. The view provides estimates for:
beta, the disease transmission rate alpha, the recovery rate epsilon, the incubation rate gamma,the immunity loss rate
Dynamical Systems View (Lyapunov Analysis)
This view displays the rate of separation in phase space (I vs. S) of the trajectories representing two different data sets or disease models. The rate of separation is then plotted vs time in a second chart. The rate of spread of any infectious disease defines a dynamical system. The Lyapunov exponent of any dynamical system describes the rate of separation of infinitesimally close trajectories in phase space.
Cross Model Comparison (RMS compare)
Given a data set and the results of a model (or two model generated data sets), the Root Mean Square (RMS) comparison function shows the RMS difference between the two as a function of time.
The Epidemic View
This view displays the aggregated data (e.g., S,E,I,R, births, and deaths) as a function of time. It also creates a summary file integrating over the data from all locations in a previously run scenario. It also shows the incidence or "newly infectious count" for the aggregated data.
What are other features are available in STEM?
- A full implementation of the STEM graph based simulation engine for spatiotemporal modeling
- Geographic visualization of the spread of disease using internally implemented graphics
- Geographic visualization of the spread of disease using Google Earth
- "Wizards" to create Projects, Graphs, Models, Scenarios, Sequencers, and Diseases
- Visual editors to edit Graphs, Models, Scenarios, Sequencers, and Diseases
- A complete data set that defines all of the countries specified by the ISO-3166 standard includes area land mass and recent human population data
- A complete Lat/Long data set in Geography Markup Language (GML) format for all countries defined by the ISO-3166 standard
- An extensive set of predefined "Graph" fragments that can be reused in user Models
- An extensive set of predefined "Models", one for each country, that can be reused in user Models and Scenarios
- A set of predefined "Scenarios" that illustrate disease spread models around the Earth
- A predefined SEIR disease model for the Spanish Flu
- Deterministic implementations of SI, SIR and SEIR disease models.
What features are planned for future releases?
- New experimental disease models
- Enhanced editor functionality (better Drag'n Drop)
- Improvements in the interface (menu, layout, wizards, etc.)
- Improved documentation
- Improved build environment
- Lots of bug fixes
Can STEM be used for more than just disease modeling?
Yes. The core components of STEM implement a graph based spatiotemporal simulation engine. The components that extend it to disease modeling are in separate plug-ins and integrate themselves using Eclipse extension points.
What is the most novel extension to STEM?
The idea of creating a "pandemic game" out of STEM has been discussed by its developers for some time. The basic idea would be to have "players" use their copies of STEM to connect to a central server with a single shared model. The players would make (or not make) decisions based upon their geographic assignment and these would be communicated to the server which would then update and propagate the changes to the model to the distributed player machines.
Can STEM be used for "situational awareness"?
Yes. Basically, you can run a simulation in "real-time" with a Decorator that interfaces to the outside world. That Decorator can access data from outside of the simulation (e.g., from a database or a web service) and then "inject" it into the canonical graph that holds the state of the simulation.
It should be possible to extend STEM to use an existing simulation to initialize other simulations so that users could monitor the world and then spawn off different identically initialized Scenarios that simulate different options given the current world state.


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|Map of El Rancho Rincon De Los Carneros, Circa 1880 - "P.Flannagan" indicated.
Journaling my genealogy research online seems to be the right thing to do for the future of my research rather than hiding it away in some box or drawer in my home. This blog is more of a diary of my research which expands as I go. Know that a post from last year may have more updated research in a different post. I love the discovery process which has resulted in such wonderful success in finding my roots. If you comment and are looking for a response, please leave me an email address.
Wednesday, October 2, 2013
Wordless Wednesday - Carneros
Posted by zelsersk at 6:00 AM
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Guide to Geologic Hazards in Alaska
- Ashfall
- Airborne ash that falls from an eruption cloud, and the resulting deposit. (Neuendorf, K.K.E. and others, 2005)
- Even small amounts of fine ash fallout may cause respiratory problems in some humans and animals. Re-suspension of ash by winds may prolong the unpleasant effects of ash fallout long after an eruption. Heavy ash fallout may interfere with power generation and electrical equipment, damage air filters and gasoline engines, interrupt radio and cell phone transmissions, and greatly reduce visibility. The weight of very thick ash falls may collapse roofs, especially when mixed with rain or snow. http://doi.org/10.14509/7042" href="/pubs/id/7042">(RI 2004-3)
- DGGS online catalog of government agency publications relating to: Ashfall
- U.S. Geological Survey (USGS): Volcanic ash...what it can do and how to prevent damage
- Alaska Volcano Observatory (AVO): Homepage


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Email marketing & social media integration
Retain their attention
Loyalty or how important is to keep your clients close
Loyalty through e-mail in Romania?!
Something about loyalty
Landing page optimization
8 seconds to create a conversion
Development administration lists/databases
A new list of subscribers for e-mail marketing?
Collect addresses efficiently based on indicators
How you regain inactive subscribers?
Indicators in list clean-up
Marketers, running after newsletters subscribers
More efficiency through correct integration of clients data
New subscribers, future clients
Solutions for database growth
Email Marketing Strategy
3 tactics of using dinamic content in the email marketing programme
Administration strategies of frequency preferences
Colectarea adreselor de email prin tactici offline
Convergence - more than a word in fashion
Email marketing, more than a simple newsletter
Essential elements for building a relationship
Genereaza lead-uri si creste listele de abonati folosind targetarea comportamentala.
Grow your clients loialty through email integrated contests
How to create efficient birthday emails
How to Delegate the Acquisition of New Subscribers to the Subscribers Themselves
How to grow your database
How to optimize the transactional emails
How to plan your holiday email campaigns
How to sale through email on holidays
How to use behavioural analysis in a creative manner
Lifetime value vs short time profit
Make your holiday email unique!
Persuasion in email marketing
Prepare your email for holidays
Strategii de optimizare a rezultatelor in email marketing: testarea subiectelor
The elements of a loyality strategy
The imperative of relevance: why and how to become more relevant
The newsletter - more than an efficient loyality instrument
What is the best frequency for sending newsletters?
Would you like fries with that? or how to integrate cross-selling into a newsletter
Creation Email - Design, Copywriting & HTML Tips
Eternal question: Video in email?
How to pass from 'Received' to 'Read' in email marketing?
Newsletter design, deliverability & interactivity. Do you think that a newsletter may be projected anyhow?
The key element of the newsletter? The Subject
The power of call-to-action - Make them click!
Segmentation, Targeting & Email Personalization
Building the complete profile of your subscriber
Dynamic content or how can communication be personalized through email
Email marketing: arts or science?
Folosirea istoricului comportamental in targetarea newsletterelor
Relevancy - principal ingredient in a prescription of a success company of email marketing
Segmentarea bazelor de date in functie de activitatea userilor (activi / inactivi)
Segmentation -
Succes in email marketing: segmentation
Surveys: the best feedback
What about a unique email for each of your subscribers?
What does not interest me
Delivery & ISP Relations
3 advantages in utilization of an ESP (Email Service Provider)
Again about reputation in email marketing
Colect addresses efficiently based on indicators
Deliverability, more than a simple indicator in email marketing
Discover what reputation means in email marketing
E-mail marketing facing spam
Face to face with deliverability in email marketing
How to maintain a good online reputation?
The importance of reputation in email marketing
The truth about deliverability in email marketing: 1 of 5 does not reach destination
Who reported me?
Indicators and Email Marketing Tests
A/B Tests : The Mathematics behind email marketing
About email and prime time
Absolute truth in communication on email through A/B test
Customer information tracking
Do we correctly evaluate the success of an email marketing campaign?
E-mail marketing generates the biggest respond rates
Efficiency in anniversary messages
Email render rate - The new indicator in email marketing campaigns measurement
Indicators in lists clean-up
Loyalty actions efficiency measures in recomandations also
Microphone test in email marketing: A/B test
Teste de reactivarea a clientilor inactivi in email marketing
Which is the perfect moment for sending newsletters?
Email Marketing Legislation
Antispam legal document in Canada (approved by the Parliament - April 2009)
Antispam legislation in New Zeeland
CAN-SPAM Act 2003 (Controlling the Assault of Unsolicited Pornography And Marketing Act of 2003. Legal document in USA)
Changes in CAN-SPAM Act - May 2008
Explanations regarding legal aspects about spam in Russia
Explanations regarding the unsubscribe process in Germany
Explanations regarding unsubscribe process in Germany
Final Amendments to 'E.Privacy' Directive
How spam world has evolved, via Project Honey Pot
Law of electronic commerce - 365 since the 7th of June 2002 (Legal document which reglements in Romania the unsolicited commercial sending of messages)
Reglementations regarding 'privacy' and electronic communications in UK (2003)
UE Directive regarding Personal Data Protection
Trends and Tips
2006 in email marketing
A new beneficiary of newsletter: the advertiser
About a banner eficiency inserted in a newsletter
Administration strategies for frequency preferencies
Copywriting tips for email
How do email and social media work together?
How to make money from a newsletter
HTML5 - The next big thing
Make the most of your email preheaders
Mistakes in email communication (II)
Mistakes in email communications (I)
Miths and lies in e-mail marketing
ROI in social media
SEND-TO-A-FRIEND : Bacause a friend recommendations is stronger than traditional publicity
Send-to-a-friend button versus share on Facebook/Twitter
Solutions to integrate video content in emails
Subscribers interest for newsletters is growing
Social media strategy
Email marketing & social media integration
Research and white papers
Delivery Report 2006 - 2007
Engagement tactics in email - A conversation guide with your subscribers
Holidays in retail - email marketing guide
Inbox Design Inside 2008 - study regarding email clients distribution used in Romania
Inbox Review 2010 - The most utilized email clients in Romania
Inbox Review 2012. Evolutii in email marketing
Inside 2007
Inside 2008
INSIDE 2009 - the study analyzes the way newsletters have been read in 2008
INSIDE 2010, the 5th edition. A complete analysis about the way the email messages were read in Romania in 2009
INSIDE 2011, the 6th edition. 2010-2011 email marketing trends.
Email Marketing Dictionary
Effectively manage aspects of email marketing campaigns: list management, deliverability and analysis.
Noii abonati sunt cei care au probabilitatea cea mai mare de a genera vanzari. De aceea atragerea permanenta de noi leaduri devine un element critic pentru cresterea business-ului.
Monitor your campaigns ROI.
Copyright White Image © 2019. All rights reserved
Politica de confidentialitate
Termeni si conditii


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Youre familiar with the term self-love and youve been doing the work. But how do you know your self-work is effective How can you tell if the work youre putting in is yielding the results you seek Because this kind of personal evolution touches our mental, physical, and emotional selves, the effects of our self-love […]
The post These 3 Signs Prove Youre Having a Self-Love Evolution appeared first on YogiApproved.
The Taurus sign is dependable, patient, and a lover of all that is beautiful. The first earth sign in the zodiac, Taurus cherishes stability and sensuality and anything soft, silky, luxurious, and rare. Material possessions rule this zodiac sign but not in a greedy gotta have it all way . . . there is just […]
The post Taurus the Bull: Heres Everything You Need to Know About This Zodiac Sign appeared first on YogiApproved.
The person you talk to most in your life is Y.O.U. Think about it – from the second we open our eyes to the time we go to sleep, thoughts are constantly running through our minds. Some are positive, some are Ariana Grande lyrics you cant get out of your brain (are we wrong) . […]
The post Change Your Thinking, Change Your Life: This Is Why You Need Positive Affirmations appeared first on YogiApproved.
The full moon is a time of shedding and letting go. It is a time to release anything that is no longer serving you and step into a place of power and intention. The energy of the full moon is palpable! It is a culmination of energy, fruition, completion and celebration. This full moon yoga […]
The post Channel the Moon's Potent Energy In This Free Full Moon Yoga Class appeared first on YogiApproved.
Lets face it, a Netflix binge sesh is a guilty pleasure we all indulge in now and again. No one would fault you for a good old binge session of Friends. But if its possible to put your binge time toward something healthy, why not A no-brainer way to turn your time on the couch […]
The post These 7 Documentaries on Netflix Will Inspire You to Become Your Healthiest Self appeared first on YogiApproved.
Item description: This Jewelry Jewelry product is by BuddhaGroove - No matter its shape, the moon always knows to keep moving! Trust the journey and have faith in each new phase of your life with a little help from this pendant. An exclusive Buddha Groove design, pendant is made of sterling silver and features all the pha... Learn More
Manufacturer: BuddhaGroove
Store: Buddha Groove is a leading online destination for Spiritual and Inspirational Jewelry, Buddha Statues, Meditation Mats and Malas, Singing Bowls, Ritual Items (prayer wheels, flags, incense), Zen Garden Accents, Home Decor (art, fountains, lighting), Apparel, Books and more. Catering to people seeking more Zen in their lives, Buddha Grooves collection of home accents, garden decor, and personal items serve, first and foremost, to inspire and rejuvenate the mind and body.
Category: Jewelry
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Blog Article
Дитячі торти, торт для дівчинки та торт для хлопчика
Multi-tiered Wedding Cakes - how to make cake tutorials
Multi-tiered Wedding Cakes - Cake decorating tutorials
Multi-tiered Wedding Cakes, Cake, decoration, step-by-step, tutorials, fondant, sculpted cakes, how-to's, royal icing, cake decorating techniques
Visit the next page:
How to Make Homemade Tiered Cakes : Decorating Cakes
How to Make a Wedding Cake: Baking and Frosting (Part 1) from Cookies Cupcakes and Cardio
How to Make a Wedding Cake: Stacking a 3 Tier Wedding Cake (Part 2) from Cookies Cupcakes and Cardio
How to Stack a Two Tier Cake - CAKE STYLE
Stacking 3 tier cake tutorial 001
Drawing Lessons : How to Draw Wedding Cakes
How To Make Brooches For Fancy Cakes with Marina Sousa
How to Make Your Own Wedding Cake: Assembly
How To Make A Wedding Cake Base- Two Tier Cake - Cake Decorating
How to make a simple 2 tier wedding cake
How to Make Your Own Wedding Cake Part 1 of 2
Peony Buttercream Flower Wreath Cake Decorating - CAKE STYLE
Cake Boss Decorating Tip - Buttercream Roses
How to Decorate Buttercream Flower Cupcakes
Swiss Meringue Buttercream Flower Cupcakes - CAKE STYLE
Buttercream Flower Wreath Cake Tutorial - CAKE STYLE
Buttercream Flower Wedding Cake Tutorial - CAKE STYLE
Buttercream Flower Series: How to Make Mums
How to Make Buttercream Roses | Cake Decorations
Carnation Flower Buttercream Cupcakes - CAKE STYLE
Buttercream Blossom Cake Decoration - CAKE STYLE
Piping Nozzle Comparisons - Wilton Star tips - Buttercream Rose
Cake Decorating Piping Techniques: How to Make Drop Flowers
Floral Wreath Cake Tutorial
Ranunculus Buttercream Tutorial
Tulip and Hydrangea Buttercream Cake - CAKE STYLE
Cake Decorating: How to Pipe Roses
Cake decorating tutorials
2D, 3D Animal cakes
2D, 3D Carved cake tutorials
Carved Snake cakes
Dragons, Dinosaurs cakes tutorials
3D Deer cake tutorial
3D carved horse cake tutorial
Fish cake tutorial
Carved Spider Cake tutorial
Rabbit (Bunny) cake tutorial
3D cat cake tutorial
Boar, Pig cake tutorials
3D Squirrel cake tutorial
Bee cake tutorial
Carved Lamb, sheep cake tutorials
Carved Ladybug cake how to
Geese, Ducks, Swans
Mole cake tutorial
The Turtles cakes tuts
Carved Fox Cake tutorial
Mice, rats, guinea pigs cake tutorials
Carved 3D frog cake how to
Cow, Bull cake tutorials
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Back Home Carroll County - A-Z Directory ("A"= Attorney "C"= Church "R"= Restaurant) Add Your Business
Imagine smelling a real steam locomotive pulling your authentic Civil War steam train through the beautiful, rolling Pennsylvania hills that Abraham Lincoln gazed on as he rode his train on the Northern Central Railway. Just as Lincoln did as he worked on his Gettysburg Address, you will come up from New Freedom, Pennsylvania to the Hanover Junction Railway Station, restored to its 1860s glory. You'll sing "Hallelujah" with the train staff and get into the patriotic spirit of the Civil War.
Attn. facebook users - friend us at
so you can then tag the photos!
CLICK HERE to download the above photos from flickr!
CLICK HERE for a full-screen slideshow (Non-Flash iPad viewable).
CLICK HERE for the photos on facebook (please tag with names).
also see: http://steamintohistory.org
About the photographer: Craig Shipp - http://CraigShipp.com - is a New Media pioneer to learn more follow him on twitter at http://twitter.com/CraigShipp or friend him on facebook at http://facebook.com/FrederickNews (friending will allow you to tag the photos with names so your friends can find them) - you can also check out his flickr photos at http://www.flickr.com/photos/areaguides/collections/
Photos can be downloaded FREE of charge from flickr in various sizes (free account required). To do so visit the following link: http://www.flickr.com/photos/areaguides/collections/
Then click on the collection and then the set to find the photo. There are also links from my articles direct to featured photos.
After you've opened the set click on the photo you want. Then click on the three dots in the bottom right to pull up the menu. Then you will see a "View all sizes" link. (you may need to be logged into flickr to have these options - accounts are FREE)
The View all sizes link brings you to a page where you can click on various size links from Square (75 x 75) all the way up to Original. Click on the size you want and then click on the link to download that size and save to your desktop or your pictures folder.
If the picture you want is needed in a high-quality .tiff un-compressed format e-mail me and I can make it available to you at no cost for personal use.
PS: Many of my videos can be downloaded from vimeo (Free account required) http://vimeo.com/craigshipp/videos
"Events define our life - if not captured, preserved and shared in photos did they ever happen?" Craig Shipp


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Apple's smartphone market share is expected to peak this year, with arch rival Samsung increasing its lead by broadening onto new platforms. See: Smartphone reviews
Smartphone shipments will account for 50 percent of all handset shipments by 2014 and become the largest handset segment in the world, according to the latest market forecasts by market intelligence analysts at ABI Research.
By 2018, 2.4 billion handset shipments with smartphones will account for 69 percent of all handset shipments. 4G or LTE handsets, like Apple's iPhone 5, will account for 35 percent of all handset shipments and 50 percent of smartphone shipments in 2018. See: iPhone reviews
"Barring an unlikely collapse in Samsung's business, even Apple will be chasing Samsung's technology, software, and device leadership in 2013 through the foreseeable future," says senior analyst Michael Morgan.
Since 2010 Samsung has grown its smartphone market share from 8 percent to over 30 percent in 2012; meanwhile Apple's market share is expected to peak in 2013 at 22 percent; remaining flat through 2018.
While Samsung's rise has been on the back of Android, which accounts for 90 percent of Samsung's smartphone shipments, the future smartphone OS landscape will likely be heavily influenced by the importance Samsung places on the elements of its OS portfolio of Bada, Tizen, Windows Phone, and Android phones.
Just as handset OEM focus has driven the success of the Android ecosystem, LTE smartphones, and handsets will also experience a rapid increase in shipment penetration as handset OEMs battle to keep their handsets relevant to mobile operators.
As 4G/LTE handsets commonly feature the latest in screen and application processor technologies, LTE handsets will also benefit from the demand of consumers looking to acquire a premium smartphone regardless of its WWAN connectivity.
"With the successful launch of the iPhone 5 and competing LTE handsets from other leading OEMs, LTE handsets will be found in the hands of many consumers who do not even have access to LTE networks," adds senior practice director Jeff Orr.
"Apple is demonstrating to the market that LTE is not the only reason to buy a premium handset."
While LTE will be the fastest-growing WWAN technology in history, the growth in smartphone shipment penetration will be driven by the rapidly growing low-cost smartphone segment.
ABI Research forecasts that smartphones with wholesale ASPs under $250 will account for 62 percent of smartphone shipments by 2018.
Mobile phone advice, reviews and news
See also:
iPhone 5 orders cut in preparation for 'evolutionary technology leap' for iPhone 6, analyst
iPhone has outsold Samsung smartphones by 219 million to 131 million, analyst


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12" x 6" Deluxe Bar Style Return Air Grille (White)
Code: RET12X6B
Price: $28.85
Quantity in Basket: None
12" x 6" Deluxe Bar Style Return Air Grille will cut down on air noise by as much as 50%, and will allow up to 50% more air flow into your heating and or air conditioning system with less grille restriction.
To Locate your Return Air Grill Size Type in our Product Search Window "RET" Then your grille size for example "RET25X20" or "RET25" this will bring up all sizes listed under "25" if you can not located the proper size please call or email us we have the largest supply on the internet and all sizes are not listed.
If you are looking for a Flat Return Air Grille, DO NOT Order a Bar Return Air Grille. Order a Stamp Face Return Air Grille.
All Bar Return Air Grilles have a ¾" lip in back of grille that fits in to the hole.
The Correct way to Order your new Return Air Grille is by measuring the hole size.
Measure the Holes Width and Height. If you're Return Air Hole Size is 25" wide by 20" tall, you will need to order a Return Air Grill 25x20.
The Overall Return Air Grills Size is 1-3/4" W x 1-3/4" L to hide any paint marks on the wall.
If you order a 25X20 Return Air Grille it would measure 26-3/4" x 21-3/4".
Return Air Bar Grille Design
· 45° fixed blade core for sight proof appearance.
· Heavy roll-formed steel, aluminum, or extruded aluminum construction.
· Features extra heavy duty extruded aluminum construction, curved blade louvers for sight proof appearance, with blades assembled to frame.
· Cube Core models feature all aluminum construction with frames made of heavy extruded aluminum.
· Surface mount, for Residential or Commercial Ceilings, Wall, tee-bar or lay-in, and tee-bar panel frames.
· Durable powder coat paint finish.
· Color Bright White.


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Looking for mother and father of William Harper born 1704 believe in Ulster, Ireland. He was married to Margaret Knox born 1711. They both and their family, Benjamin b 1737, Robert b 1742, Daniel b 1747, William b. 1749, James b 1751, John b 1753 and Jane D. b 1756 all in we believe Ulster, Ireland and moved to America in 1767. Would any have any information on this family of who his parents were and where they were born? Other researchers show his father as William married to Elma Joyce Woodward both born in England but I am not so sure that is true. No factual evidence to prove it. Also if any does find this family and have any birth information or baptism information and their parish. Anything would be greatly appreciated. I th
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The original drink appears in Trader Vic's Bartenders Guide from 1972 and is sometimes referred to as the Floridita Cocktail. The La Florida Cocktail is the creation of Constantine Ribailagualt and was one of the signature drinks of the La Florida bar in Havana, Cuba.
It's name is strikingly similar to the Floridita Daiquiri but they are two different drinks. The daiquiri contains maraschino liqueur while the cocktail uses crème de cacao, sweet vermouth, and grenadine as the sweeteners. This particular version of the drink appears in the PDT cocktail book and is the creation of Jack McGarry.
La Florida Cocktail
2 oz Banks 5 Island Rum
.75 oz Lime Juice
.5 oz Crème de Cacao (Marie Brizard)
.25 oz Sweet Vermouth (Cinzano)
1 barspoon Grenadine (Hibiscus Grenadine)
Shake with ice and strain into a chilled cocktail glass. Garnish with a lime wheel and enjoy.
The drink is well put together and despite the .5 oz of Crème de Cacao the chocolate flavor is still subtle and interwoven with the herbal qualities of the vermouth. The final flavor is not one you would except but its delicious and well worth exploring.
7 Daiquiri's in 7 Days continues tomorrow with the: Royal Daiquiri
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Our items are made by hand, we may not have every item in-stock, please allow about 2 weeks for order completion. As with any handmade product you will find small variations between finished items. Small variations of tone or specks of other colours within an item, as well as occasional small slubs in the cotton and sewing should be embraced as signs of a genuine handmade product.
pear basics queen duvet cover panel
take a bite – a golden green
These duvet cover panels are one side of a queen sized duvet cover. They have unfinished edges and are intended for use in a duvet cover or similar sewing project. You can find a lot more information about them in the tabs below. Just like everything at bed these are all sold individually so you can mix and match colours.
*all dyed duvet cover panels are final sale
Because duvet cover panels are only made and dyed when someone wants one, they are final sale. If you are unsure about a colour, please order a free swatch in that colour before you buy a duvet cover panel.
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A reader who is closely following the Scott Brown-Elizabeth Warren race offers these observations:
In the beginning of the campaign when Warren was struggling with her lies about her fake indian roots, her candidacy was as deep as a kiddie pool. She was like a broken record spouting the same exact [lines] over and over and over no matter what the question to her was. If you asked her about the heat and humidity, she'd go into her spiel about the middle class getting "hammered". Hammered was her key word, for a LONG time until people started making fun of her for it, now she never says it.
That line of attack did not seem to find any traction at all, so now it's Warren's version of the war on women theme. For the past 3 weeks or so she has been running commercials on the war on women and sticking to those talking points in any interview. Yesterday at the Labor Day parade in a town west of Boston which will go to Brown pretty strongly she was asked a question and gave the talking points.
The war on women is a great example of her aimless campaign. She has no real reason to run other than Obama and some Washington political talking heads thought it was a good idea. Her whole campaign is forced; she is not natural and it's clear she is running for her own aggrandizement and not for some noble reason. . . .
Brown [is] the perfect Republican for Massachusetts. Brown has 2 very attractive, well-raised girls in their early 20's (one. . .finished high on American Idol, had a full basketball scholarship to BC and now is trying for a singing career). His wife is Gail Huff was a well known tv reporter in Boston for 20+ years, and is very well liked by everyone. Brown brushes off. . .the war on women theme with his living with three women, and his wife does the same.
He is near teflon on every subject because of his personal/family background, but as stated in your piece, he is a moderate. Warren should be running on what she can do for people rather than all the talk about [Brown's "extremism"] because that just doesn't sell.
Over the weekend the incompetent state party chair distracted the campaign even more and set Brown up to look even better with how he handled the stupid comments [about Brown folding clothes like "an honorary girl"]. At the DNC, Warren is being dogged by the fake indian issues again.
Warren seems to think the indian questions are a past issue that she has sufficiently answered. They are not, as she has never addressed them directly. Everyone, even her supporters know she lied about being native american to get ahead in her career. This undercuts everything about her candidacy as she has zero credibility.
Brown has been on local radio a few times recently and although he will not get into specific debate tactics as he said, Warren needs to release her employment record with Harvard and Penn to answer the question of whether she received preferential treatment. He's going to hit her with that at the debate and she will be dogged by the press to release the records to clear the air. Brown can simply say if she did nothing wrong, why is she unwilling to release them. That will be the end of the campaign as the D's will turn on her in the closing weeks as they see the certain loss.
I think she is actually worse than Coakley to answer you question. She's slightly smarter but a far worse candidate for a number of reasons. They really made a mistake clearing the field for her too. Romney is stronger because of the tough primary, he worked out the bugs and took the attacks. Warren has never been challenged at all. When she is challenged by the press, during the first round of indian issues, she gets very shrill and defensive. She isn't relaxed, she stiffens and comes across very poorly.


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1 3/4" Bearing Cassette
These 1 3/4" bearing cassettes are designed to be used with any modern Margay 3 bolt bearing hanger and 1 3/4" bearings only.
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1 3/4" Axle Bearing
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Having trouble keeping everything on the axle in place? These 1 3/4" axle lock collars are what you need then. Easily keep your hubs from moving on the track with these collars.
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Drugs and Justice
On Friday, January 31, MADP will host the annual MLK Commemoration Brunch in PLV featuring neuroscientist Carl Hart, PhD, on how drug policies cause injustice.
The Office of Multicultural Affairs and Diversity Programs presents the 14th Annual Dr. Martin Luther King, Jr. Commemoration Brunch on Friday, January 31, from 11:00 a.m. to 1:00 p.m. in the Gottesman Room on the Westchester Campus. Keynote speaker Carl Hart, PhD, groundbreaking neuroscientist and author, will discuss how drug policies cause injustice. In his book High Price: A Neuroscientist's Journey of Self-Discovery That Challenges Everything You Know About Drugs and Society, Hart shares his story of growing up in a tough neighborhood and how it led him to his pioneering work in drug addiction.
Currently, Hart is an Associate Professor of Psychology in both the Departments of Psychiatry and Psychology at Columbia University, and Director of the Residential Studies and Methamphetamine Research Laboratories at the New York State Psychiatric Institute. A major focus of Hart's research is to understand complex interactions between drugs of abuse and the neurobiology and environmental factors that mediate human behavior and physiology.
He is the author or co-author of dozens of peer-reviewed scientific articles in the area of neuropsychopharmacology, co-author of the textbook Drugs, Society, and Human Behavior, and a member of an NIH review group. Hart was recently elected to Fellow status by the American Psychological Association (Division 28) for his outstanding contribution to the field of psychology, specifically psychopharmacology and substance abuse.
RSVP to firstname.lastname@example.com.
Co-sponsored by the Kappa Zeta chapter of Alpha Phi Alpha Fraternity
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YouTuber and fashion expert Roxana Saravia '20 has been using her platform to inspire the next generation of Pace students. She also works on The Wendy Williams Show as a wardrobe intern. Talk about #influencer.
The Fashion Influencer
On Tuesday, May 7 (PLV), and Wednesday, May 8 (NYC), PaceDocs invites you to the screening of their much-anticipated documentary about Kīlauea's volcanic eruption and the resiliency of the Hawaiian people.
Hawaii: Living on the Edge in Paradise?
The dream of the '90s is alive—at Pace! On Saturday, April 27, relive the nostalgia at the Programming Board's annual spring carnival with rides, food, and plenty of '90s music. It'll be totally radical.
Springback 2019 (PLV)


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You are currently browsing the tag archive for the 'Hope' tag.
Tonight as Tim and I were driving around I saw the sign for a church stating PALM SUNDAY WORSHIP AND PICNIC!
It was undoubtedly the announcement for last Sunday's service. And just like last Sunday a part of me, bigger than I would like to admit, grumbled, so irritated by this repeated excitement.
Confession: I left church on Palm Sunday.
I know, I know, it isn't right, but what is done is done. We had raced out the door of our apartment to make it on time. As we walked into the service I was handed a palm leaf, nice. A speaker took to the stage as we found our seats, enthusiastically reading from one of the Psalms. It was about a king, and gates, and a lot of joy. I took a deep breath and tried to convince my heart to resonate with the reading, but this wouldn't happen. I found my heart shutting down and I just could not join in the excitement.
My grumbling heart was not honoring to the Lord, and so I asked Tim if we could leave. He is so patient and kind, and as soon as we walked out the door His first question was "do you want to talk about it?" I love him deeply.
I got on Facebook today to find pictures of smiling kids with palm leaves only to feel disappointed in my inability to appreciate the celebration most people were experiencing.
Is it because I'm going through this time of questioning? Do I have a dark and cold heart?
So today as we drove and I once again could not react to this excitement proclaimed in all caps, I grumbled.
This Lenten season I chose to journal my journey to the cross, but after my experience the past few days, it seemed my journaling had been futile.
I came home and curled up on the couch ready to seek answers to more of my questions, choosing to read "The Problem of Pain" by C.S. Lewis. However a few pages in I began to randomly flip through the rest of my book which is a collection of his writings. I flipped open to "A Grief Observed" and I was instantly taken by the personal introduction written by his step son. Douglas Gresham explained that this work had been a product of Lewis's grief after losing his wife. Each heart felt word kept pulling me further into his writing.
"I have no photograph of her that's any good. I cannot even see her face distinctly in my imagination… But her voice is still vivid. The remembered voice – that can turn me at any moment to a whimpering child."
Can you imagine that pain? Can you imagine that loss? Some of you may not have to because it is already all too real, and for that I am so incredibly sorry.
I read this, and I cry, deeply. Sorrow reaches into the deepest parts of my heart and soul. I read this and I cry because I know that this separation will one day be all too real for us as well. Tim and I. One day, most likely, one of us will be without the other. I can't imagine, I don't want to imagine my life without this beloved partner and friend I have. I feel incomplete without Him. I can't imagine, I don't want to imagine him living a life where I can't console him.
It may be silly to think in this way, I can hear people now: "Enjoy what you have now!" "Don't worry about tomorrow!"
Here is the reason I am allowing these emotions to seep so deeply tonight. Yesterday the church celebrated Jesus riding in on a donkey, Sunday we will celebrate him raising from the dead, but before that, on Friday, we will mourn his death.
Friday, we remember what he did, and we must also remember why: separation.
He from we.
I don't want my words to ruin this powerful story, I am going to try to do it justice now.
He made us. Why us? I don't know. He made us. He loved us. Why? I don't know. He and we shared everything, until the day we chose we before He. He was our creator and our truest lover, and his heart was broken. He was separated, like a groom from his bride. Can you imagine the agony He must have felt? Why would He subject Himself to this? I don't know.
But because of our choice we and He were separated. We were separated like death separates loved ones. And the resulting grief was as real as the grief of a husband for his dead wife.
How do I know that He felt the pain of separation from us? Because of everything He did to get us back. The story is long, stretching thousands of years, the people change, the kingdoms change, but the story does not: A God desperate to end the separation between Him and His creation. A God desperate to end the death we chose, so desperate, He was willing to die Himself.
This is the story of Friday. And without this, Sunday will have lost all significance. We cannot celebrate if we cannot remember the depth of His grief in our death and separation from Him. We cannot sing praise until we willingly mourn the reason this season exists in the first place.
We were separated from the love of our life. You were separated from the love of your life. I was separated from the love of my life.
Because He chose to chase after, because he created a story that seamlessly weaves itself together over thousands of years and through countless people, because he ends this separation in death, which is our consequence, because we observe his grief on Friday we raise our hands on Sunday and our hearts are full of joy.


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Prophecy on Pope Fulfilled by Eclipses?
Newsmax | April 7, 2005
A 10th Century Irish bishop - St. Malachy - predicted every pope that would preside over the Catholic Church.
Almost ten centuries ago, Malachy predicted this pope would be noted by an eclipse of the sun.
In an eerie coincidence, John Paul II was the only known pope to be born on the day of a solar eclipse.
But the prophetic link doesn't end there. Pope John Paul II will be buried this Friday during another solar eclipse.
Astronomers say that on Friday, the day of the Pope's funeral, a partial solar eclipse will blot out most of the sun and darken a wide area of the world, from the South Pacific to the Western Hemisphere.
Solar eclipses are not unusual. But what makes this coming Friday's eclipse notable is the fact that there was a near total eclipse of the sun seen across Europe on May 18, 1920, the very day that John Paul II was born in Poland.
Adding fuel to the arcane speculation about these events is the prophecy of St. Malachy.
Malachy was discovered to have left behind a prophetic list of all future popes beginning with Pope Celestine II, whose papacy began in 1143 A.D., up to and including the 112th. The list includes John Paul and just two more popes who will follow him.
In his list of popes, he uses a single line in Latin identifying a characteristic of each pope.
The description applied to the 110th pope on his list - John Paul II - is "De Labore Solis" (Of the Solar Eclipse), which seems to add great weight to the validity of St. Malachy's chilling prophecy: that the next two popes chosen to succeed John Paul II will be the last popes.
After the reign of the last pope, "Peter the Roman," St. Malachy wrote, Rome will be destroyed.
As NewsMax.com reported April 3, Saint's Prophecy: Only Two Popes Remain, the 112th prophecy says, "In the final persecution of the Holy Roman Church, there will reign Petrus Romanus (Peter the Roman), who will feed his flock amid many tribulations; after which the seven-hilled city [Rome] will be destroyed and the dreadful Judge will judge the people," an indication that the world will end.


text: Suriname Are you tired of retailers in the United Kingdom not shipping apparel, electronics, appliances, and other merchandise to Suriname? Sign-up for Ukaddress.com to have all of your favorite merchandise from Harrods, Amazon.co.uk, eBay.co.uk, boohoo.com and thousands of additional retailers reshipped directly to you in Suriname? At UKaddress.com, we make the process of buying and shipping products from U.K. retailers easy and affordable, saving you both time and money – no matter how remote your location. Unlike other freight forwarding companies, UKaddress.com offers a variety of shipping options including USPS, DHL, UPS, and FedEx for reshipping merchandise to Suriname. With UKaddress.com, freight forwarding and reshipping to Ethiopia from companies in the U.K. has never been easier. Simply reship , receive, and relax while your clothing, computers, smartphones, and more are reshipped directly to you in Suriname. How It Works! 1.Sign up for your U.K. mailing address for a minimal cost 2.You can start your online shopping from your favorite U.K. retailer UKaddress.com is committed to providing customers with high quality service that is easy and hassle-free. Whether it's cutting edge technology, the latest fashions, or household staples, our incredible shopping tools and services help you find them, buy them and get them anywhere in the world –faster, safer and less expensively! UKaddress.com proudly services cities in Suriname.


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Report of a Functional Cure in an HIV-Infected Infant
March 6, 2013
On Monday March 4th at the Conference on Retroviruses and Opportunistic Infections (CROI) in Atlanta, details were presented on a case of a potential "functional cure" of HIV infection in an infant. The story has already broken widely in the media due to a CROI press conference held on Sunday afternoon, during which the researcher describing the case, Deborah Persaud, gave a preview of the data. The webcast of Persaud's talk is now available for viewing online (it is the 7th presentation in the session entitled "Is There Hope for HIV Eradication?").
The context of the case report is unusual because the mother was not diagnosed with HIV infection until in labor, and there was no opportunity to give her antiretroviral therapy (ART) to reduce the risk of mother-to-child transmission. The infant was therefore considered at high risk of acquiring infection and HIV DNA and RNA tests were performed at 30 and 31 hours after birth, respectively. The HIV DNA test was positive, and the RNA test showed a viral load of 19,812 copies. Although current US guidelines recommend initiating a prophylactic regimen of AZT and nevirapine pending the results of virologic testing, the treating pediatrician, Hannah Gay, chose to initiate combination ART including AZT, 3TC, and nevirapine (the latter at the therapeutic rather than prophylactic dose). Nevirapine was switched in favor of Kaletra after seven days. Subsequent sequential viral-load testing showed the typical decline in response to treatment, with measurements of 2617 copies, 516 copies, 265 copies and then less than 48 copies (beneath the limit of detection).
ART was maintained for around 18 months until the mother and infant were lost to follow-up. When the infant was returned to care around five months later, Gay learned that treatment had been stopped. The reasons for the disengagement from care and cessation of treatment have not been made clear, with Gay stating in one article only that the mother was battling "some life changes."
Testing of the infant after the return to care revealed a highly unusual outcome: viral load remained undetectable despite the five-month period off ART (there have been many studies of pediatric ART interruptions, all demonstrating that viral-load rebound occurs rapidly, typically to very high levels, almost without exception). This prompted Gay to consult with external experts in pediatric HIV infection Deborah Persaud at Johns Hopkins University and Katherine Luzuriaga at Massachussetts General Hospital. The results of further investigations led to the findings presented by Persaud at CROI: several independent laboratories with expertise in searching for trace amounts of HIV evaluated samples from the infant but could only rarely detect extremely low levels of viral genetic material (there was no detectable replication-competent HIV).
These results echo those from follow-up studies of the single adult considered cured of HIV infection, Timothy Brown. Methods employed included digital droplet PCR, single-copy assays for HIV RNA, and a test for viral outgrowth from 22 million resting CD4 T cells. Immune responses to HIV, including antibody and CD4 and CD8 T-cell responses, were not detectable. Genetic studies showed that neither mother nor infant possessed the CCR5-Delta32 mutation or any HLA genes known to be associated with control of HIV replication. The totality of the findings has led the researchers to conclude that the infant represents a case of a functional cure of HIV infection (essentially an infant equivalent of Timothy Brown); the virus may not have been completely cleared, but at the current time -- after over 10 months off ART -- no viral activity is detectable.
Not too surprisingly, the media interest in the story has been intense. Several stories, including a piece in The New York Times, have included quotes from scientists suggesting the possibility that the infant was not infected in the first place. This scenario is difficult to reconcile with the stepwise decline in HIV RNA levels after ART initiation (this would have to involve not only four sequential false positive RNA results, but false positive results that also coincidentally mirrored the expected viral-load decline in response to ART -- a possibility that seems vanishingly unlikely). Another skeptical viewpoint cited by some articles is that HIV might have been cleared even in the absence of ART. This suggestion is based on occasional reports in the scientific literature of apparent transient HIV infection in exposed infants; however, a study published in 1998 that analyzed many of these cases in detail showed that most were explained by PCR testing contamination or sample mislabeling. Even the few reports that could not be fully explained by these problems were considered to be lacking the evidence necessary to formally prove that transient infection had occurred.
Some other aspects of the case deserve comment: although the baseline viral load of 19,812 copies might seem relatively low in the context of adult values, it should be noted that data on early viral loads among infected infants indicate this level is not atypical. A study published in 1998 reported that "all 18 infants defined as in utero infected by DNA PCR or coculture (or both) were also positive with a wide range of plasma HIV-1 RNA values within 48 h of birth and a median level of 26,940 HIV-1 RNA copies/mL (25th and 75th percentiles, 1556 and 468,390)."
In terms of other cases of pediatric ART interruptions in which viral-load rebound did not occur, a search of the literature did not turn up many examples. In 2006, researchers from Massachusetts General Hospital published a case report regarding a perinatally infected child who stopped ART as a teenager and maintained undetectable viral-load levels for five years of follow-up; the individual was heterozygous for the CCR5-Delta32 mutation and, unlike the infant described by Persaud, displayed strong HIV-specific T-cell responses. A 2008 survey of outcomes among children and adolescents undergoing unstructured ART interruptions notes the following: "In only 1 patient (6% [1 of 17]) did HIV-1 RNA remain undetectable after 12 months off therapy." However, no additional information is provided, and the cut-off for the viral-load assay used was <400 copies.
Based on the data presented, the Persaud case report appears unique, and the evidence that HIV infection occurred and has subsequently been controlled or even cleared after short-term ART is more compelling than some of the skeptical comments in the press have suggested. However, there is a lack of stored samples that might be able to bolster the evidence by confirming the genetic relationships between the separate virus samples from the infant and the linkage to the virus in the mother. It also remains possible that viral load could rebound at some point in the future.
The implications for pediatric HIV care and cure research are now the subject of ongoing discussions:
Update 3/14/2013: On Monday March 11th in the Wall Street Journal, Dr. Mark J. Seidner from Massachussetts General Hospital and Harvard Medical School published an opinion piece arguing that the case represents an example of successful infant post-exposure prophlaxis (PEP) against HIV infection, rather than a cure of HIV infection that had occurred in utero as Persaud and colleagues have suggested. There is a published case report of an adult recipient of an HIV-infected blood transfusion who showed a single viral load value of 3 copies/mL (the lower limit of detection of the assay) but proved to be uninfected after receipt of PEP. However, there are also published studies that include assessments of viral load values in infants receiving PEP to prevent mother-to-child transmission and none appear to offer examples consistent with the idea that viral load values are detectable in this situation e.g. see this large French study from 2012, and a US analysis from 2003; the latter reports two examples of low values in infants receiving AZT prophlyaxis, but they are considered false positives because DNA PCR tests taken the same day were negative (unlike the case reported at CROI).
Richard Jefferys is the coordinator of the Michael Palm HIV Basic Science, Vaccines & Prevention Project Weblog at the Treatment Action Group (TAG). The original blog post may be viewed here.
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This article was provided by Treatment Action Group. It is a part of the publication Michael Palm HIV Basic Science, Vaccines & Cure Project.
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Hagerstown Community College is now offering new evening course packages, designed to allow students to take multiple classes each semester by attending class one or two nights a week.
"We have expanded our options for students who take courses in the evening. The new and improved schedule will allow students to complete their degrees and certificates more quickly," said Jennifer Haughie, director of admissions, records and registration. "We hope this change will provide greater access and convenience for our current and future students."
Students who want to attend class one evening per week can earn up to six credits by taking a class from 5 to 7:45 p.m., and a second class from 8 to 10:45 p.m. Students who want to attend class two evenings a week can earn nine to 12 credits per semester, by choosing from a variety of time frames, within the 5 to 10:45 p.m. window.


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|De Graff, Dirk
|Alippi, Adriana
|Brown, M
|Evans, Jay
|Feldlaufer, Mark
|Gregorc, A
|Hornitzky, M
|Pernal, S.f.
|Schuch, D.m.t
|Titera, D
|Tomkies, V.
|Ritter, W.
Submitted to: Letters in Applied Microbiology
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 9/26/2006
Publication Date: 11/1/2006
Citation: De Graff, D.C., Alippi, A.M., Brown, M., Evans, J.D., Feldlaufer, M.F., Gregorc, A., Hornitzky, M., Pernal, S., Schuch, D.F., Titera, D., Tomkies, V., Ritter, W. 2006. Diagnosis of american foulbrood disease in honeybees: A synthesis and proposed analytical protocols. Letters in Applied Microbiology. 43:583-590.
Interpretive Summary: American foulbrood is a devastating bacterial disease of immature honey bees. With the international movement of bees, there is a need to standardize diagnosis methods for this disease. This paper describes the clinical symptoms of disease in field colonies and several new and existing laboratory methods to determine the precise agent of disease. This information will be used by regulatory scientists and agencies involved in insuring the safe transport of bees. The information will also be used by researchers attempting to understand the disease and develop new methods of control.
Technical Abstract: American foulbrood (AFB) is the most devastating bacterial disease affecting the larval and pupal stages of the honeybee (Apis mellifera). As the discrimination between AFB and powdery scale disease could no longer hold stand, the pathogenic agent has recently been broadened up to the whole species Paenibacillus larvae. The creamy, sometimes dark brown glue-like larval remains represent the most obvious sign of AFB but several other clinical symptoms have been described. Sensitive and selective culture media are available for isolation of these spore-forming bacilli and the type of samples that can be collected for diagnosis of a suspect bee colony has further been expanded. PCR methods for identification of the pathogen and for genotyping have been developed. But when highly sophisticated equipment is lacking, the biochemical profiling of suspicious bacterial strains and several homemade or commercialized immunotechniques provide an adequate alternative for the molecular identification of P.larvae.


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INDIANAPOLIS -- In 2010, consumers will seek out educated, experienced fitness professionals, according to the American College of Sports Medicine's (ACSM) top fitness trends survey.
A down economy, coupled with the increase in organizations offering accreditation for fitness professionals, was credited for making this the top trend for next year.
"Consumers are more conscious of their finances than ever," Walter Thompson, lead author of the fitness trends survey, said in a statement. "If they're going to work with a fitness professional to improve their health, they're going to do their homework and find someone who's educated, experienced and certified by a reputable organization such as ACSM."
The fourth-annual ACSM survey was based on feedback from 1,500 respondents. Some 37 potential trends were given as survey choices, with the top 20 ranked and published by ACSM.
Strength training was listed second in the rankings, which is an indicator of the increased focus on strength training for various populations, survey authors noted.
ACSM's top 10 fitness trends for 2010 are:
1. Educated and experienced fitness professionals
2. Strength training
3. Children and obesity
4. Personal training
5. Core training
6. Special fitness programs for older adults
7. Functional fitness
8. Sport-specific training
9. Pilates
10. Group personal training
The full list of ACSM's top 20 trends is available as a PDF download.


text: [i:Vibes] :: View topic - Mondo Records: The Best of 2017 OUT NOW! Guidelines FAQ Search Memberlist Usergroups Bookmarks Register Profile Log in to check your private messages Log in Main Menu Frontpage News Reviews Interviews Party Reports Artist Profiles Label profiles Diaries Tutorials What is... Links Radio-info Interactive Forum User Stats Info FAQ Crew-info i:Vibes Info Site Updates Mondo Records: The Best of 2017 OUT NOW! [i:Vibes] Forum Index -> Artist and Label News View previous topic :: View next topic Author Message dt8projectPodium DancerVibes: 61.10Joined: 23 Sep 2007Member #: 12,393Posts: 261 Post subject: Mondo Records: The Best of 2017 OUT NOW! Listen / Buy: https://mondorecords.lnk.to/MNDSM61-BestOf2017 It has been another hugely successful year for Mondo Records. Thanks to signing yet more top quality electronic music, and bringing forth some of the brightest stars in the scene right now. Some of the pinnacle moments of our year of course include the release of our hotly received 'Mondo Sessions 003' compilation, which was mixed by label owner and A&R Darren Tate (aka DT8 Project). As part of this project and of course our ongoing mission, was to sign and nurture the best talent in the electronic music scene. So much so, when it came to selecting our top 25 tracks of the year, it was no easy feat! Our 'best of 2017' bundle features producers and artists such as Manda Dex, Orano, Konstantin Kolyada, Atherium, Royal Zeven, High Frequencies, Cyril Ryaz, Quincy Weigert, Quervo, Hoof, Nitrous Oxide & Mysterious Movement, Ian Solano and many, many more. Grab this bundle while it's hot to ensure you don't miss some of the biggest Mondo Records releases of the year. Minimix: https://www.youtube.com/watch?v=o1XUj2F028M Visit: Mondo Records Website | Mondo Records on Facebook | Mondo Records on Twitter | Mondo Records on YouTube | Mondo Records on Soundcloud Post rating: 0 Rate this post: Not logged in Posted: Sat Dec 30, 2017 11:30 am Back to top Display posts from previous: All Posts1 Day7 Days2 Weeks1 Month3 Months6 Months1 Year Oldest FirstNewest First [i:Vibes] Forum Index -> Artist and Label News All times are GMT Page 1 of 1 Jump to: Select a forum Spam----------------Spam posts Music----------------Music discussion (trance, techno, progressive and other genres)EquipmentArtist and Label NewsRadio BroadcastsMusic Production and DJ Mix PromotionClub Listings Non-music related----------------Other discussionBuy & Sell [i:Vibes]----------------Site Feedback and Help Content Discussion----------------News DiscussionReview DiscussionInterview DiscussionTutorial DiscussionWhat is...Party ReportsArtist ProfilesLabel Profiles You cannot post new topics in this forumYou cannot reply to topics in this forumYou cannot edit your posts in this forumYou cannot delete your posts in this forumYou cannot vote in polls in this forumYou cannot attach files in this forumYou can download files in this forum Powered by phpBB © 2001, 2005 phpBB Group


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- Overall Length:8.25"
- Blade Length:3.625"
- Cutting Edge:3.25"
- Blade Thickness:0.17"
- Blade Material:Bohler N690
- Blade Style:Drop Point
- Blade Grind:Flat
- Finish:Satin, Stonewash
- Edge Type:Plain
- Handle Length:4.625"
- Handle Thickness:0.51"
- Handle Material:Titanium
- Color:Bronze
- Frame/Liner:Titanium
- Weight:5.38 oz.
- User:Right Hand
- Pocket Clip:Tip-Up
- Knife Type:Manual
- Opener:Flipper
- Lock Type:Frame Lock
- Brand:Ferrum Forge
- Model:Mordax
- Country of Origin:USA
- Best Use:Everyday Carry
- Product Type:Knife
The Mordax flipper is one of the latest 'Entry Level' knives from Ferrum Forge. This one has a milled face, bronze anodized titanium handle with a blue anodized pivot, pocket clip and barrel spacers. The full length swedge drop point blade is Bohler N690 steel with a two-tone stonewash/satin finish and flipper opener. The Mordax is outfitted with a steel lock insert/internal overtravel arrestor, H.R.D. (Hoback Rolling Detent), and caged thrust bearings.
Ferrum Forge Knife Works make a relatively small number of unique, highly sought after knives. In an effort to satisfy the demand for their fine folders they've created the "Entry Level" lineup. Generally, it's a less customized version in a limited run of 200 knives. Lest you misunderstand, these knives are anything but entry level; each one is a bona fide rock-star-of-a-knife with an exquisite build and high tolerances.


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The big news of the day was an angry Sven Nys stopping mid race to speak to a spectator who'd thrown beer at him every lap. He was pretty level headed and just had a few words, but it looked like the guy copped a beating from other spectators and fair enough!
Last year I had a few B level Belgians and some other foreigners to race against, but lining up on the start line it was pretty obvious I'd most likely be alone out the back. The other riders were either put off by the poor weather or saving themselves for Bredene the next day.
There was a massive crash as soon as we hit the the mud section. There was a huge pile up behind him and everyone was off their bike and running. The mud section lasted about 1km and involved about 20cm of sticky mud. Exhausting on the legs. Last year I had to run it all, but thanks to a combination of improved fitness and a superb set of tubular tyres, I was able to ride it all.
|There was even a bmx style set of rollers on the course.
Despite this, I was alone after the first lap. The crowd were insane though, the volume of cheers was second only to the world champs in Koksijde. I played it up, and once I'd figured I was on my last lap before being pulled, I made sure to put on a show for the crowd. Sonoko has generously allowed me to use some of her fantastic photos and you can see just how much fun I had out there.
In the end, I was the last finisher in 36th, but three laps down instead of the five from last year. Not a great result, but not too bad either.
A bloke I've met through Dirty Deeds, Paul has started importing FMB tubulars into Australia. I was frantically trying to organize tubs before I left, and on the Comptons advice I went for a set of FMB Super Muds. I can see why they were recommended to me, I've never ridden anything like them. In an ideal world, I'd have a set of their SSC's as well (their intermediate tread) for slightly less muddy conditions, but I could only fit two wheelsets in my luggage, so chose to prepare myself for the worst of the Belgian mud. They've been fantastic so far. Tread aside, the other feature which stands out is the coating on the sidewall. Dugasts are great, but the sidewalls rot if you don't paint a protective coating on them, and you have to reapply it during the season. The FMBs come standard with a coating, no hassles, no worries. They aren't cheap, but they've make a world of difference to my ride and I'm sure they've saved me from a few spills this season! If you're keen to get a set for the road or cross bike (Boonen uses FMBs....enough said), shoot Paul an email at
I have Saturday off, before the last race of my Kerst Periode and my first ever race in the Superprestige Series, a night race in Diegem on Sunday. I'll be doing everything possible to finish on the lead lap!


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