text:
For carrying out section 301 and title IV of the Public Health Services Act with respect to human genome research, $502,367,000 $509,594,000 (Department of Health and Human Services Appropriation Act, 2009)
|Sources of Funding
|FY 2008 Actual
|FY 2009 Estimate
|FY 2010 Estimate
|Type 1 Diabetes
|Subtotal, adjusted appropriation
|Real transfer under Director's one-percent transfer authority (GEI)
|Comparative transfer under Director's one-percent transfer authroity (GEI)
|Subtotal, adjusted budget authority
|Unobligated balance, start of year
|Unobligated balance, end of year
|Subtotal, adjusted budget authority
|Unobligated balance lapsing
|Total obligations
1 Excludes the following amounts for reimbursable activities carried out by this account:
FY 2008 — $22,884,000 FY 2009 Estimate — $52,290,000 FY 2010 Estimate — $53,022,000.
Excludes $111,000 Actual in FY 2008; Estimate $247,000 in FY 2009; and Estimate $133,000 in FY 2010 for royalties.
Includes FTEs which are reimbursed from the NIH Roadmap for Medical Research.
FTTP = Full-time temporary equivalent
FTE = Full-time equivalent
Major changes by budget mechanism and/or budget activity detail are briefly described below. Note that there may be overlap between budget mechanism and activity detail and these highlights will not sum to the total change for the FY 2010 budget request for NHGRI, which is $7.227 million more than the FY 2009 Estimate, for a total of $509.594 million.
Research Project Grants (RPGs) (+$1.991 million, total $153.892 million): The NIH Budget policy for RPGs in FY 2010 provides a two percent inflationary increase in noncompeting awards and a two percent increase in the average cost for competing RPGs. NHGRI will support a total of 271 Research Project Grant (RPG) awards in FY 2010. Noncompeting awards will increase by nine awards and by $1.306 million. Competing RPGs will increase by two awards and $1.800 million. NHGRI will continue to support new investigators and to maintain an adequate number of competing RPGs.
Research Centers (+$2.962 million; total $200.840 million): The FY 2010 budget policy provides a two percent average cost increase. The number of research centers is expected to continue at 45 in FY 2010.
Medical Sequencing (+$5.000 million; total $64.766 million): Large-scale sequencing technology has improved significantly. The additional $5.000 million provided will increase the proportion of the Institute's sequencing program to support new opportunities to apply genomic tools to the study of human disease.
Large-scale Sequencing (Non-Medical) (-$10.000 million; total $25.000 million): Emphasis within the NHGRI Large-scale Sequencing Program is continuing to shift in FY 2010 from non-medical to medical sequencing and to sequencing for The Cancer Genome Atlas. The $10.000 million decrease in the Non-Medical component of the program is due to this shift in the distribution of sequencing activities and is made possible by improvements in process efficiency. The Non-Medical component of the program will maintain, or possibly increase, the total amount of data it can generate within the reduced funding, because of expected increased output and decreased costs afforded by next-generation sequencing technologies.
The Cancer Genome Atlas (+$5.450 million, total $22.500 million): The program is increasing because large-scale sequencing technology has improved significantly and this additional funding will support new opportunities to use this technology to study cancer.
Translational Genomics (+$0.909 million; total $25.516 million): Expanded efforts in this program in FY 2010 will focus on genome-wide association studies (GWAS) for several additional diseases (to be chosen through a peer-reviewed competition), and drug and treatment response. New computational and experimental methods to follow up on the GWAS results to determine the specific genetic variations responsible for the diseases will be developed as well.
Section 301 and title IV of the Public Health Service Act, as amended.
This document provides justification for the Fiscal Year (FY) 2010 activities of the National Human Genome Research Institute (NHGRI), including HIV/AIDS activities. Details of the FY 2010 HIV/AIDS activities are in the "Office of AIDS Research (OAR)" Section of the Overview. Details on the Common Fund are located in the Overview, Volume One. Program funds are allocated as follows: Competitive Grants/Cooperative Agreements; Contracts; Direct Federal/Intramural and Other.
In FY 2009, a total of $127,035,000 American Recovery and Reinvestment Act (ARRA) funds were transferred from the Office of the Director. These funds will be used to support scientific research opportunities that help support the goals of the ARRA. The ARRA allows NIH to execute these funds via any NIH funding mechanism. Funds are available until September 30, 2010. These funds are not included in the FY 2009 Omnibus amounts reflected in this document.
After leading the Human Genome Project to the successful completion, in 2003, of its extraordinary goal of sequencing the entire human genome, NHGRI expanded its mission to encompass a broad range of studies aimed at understanding the structure and function of the human genome and its role in health and disease. To that end, the NHGRI supports cutting edge genomics and translational research with an emphasis on the development of resources and technology that will accelerate research and the application of new tools and findings to human health and disease. The ultimate aim of the NHGRI scientific and ethical research portfolios is to enable truly preemptive, predictive, personalized, and participatory health care.
The Nation's previous investments in the HGP and the International HapMap Project have moved us closer to a future that uses genomic information to diagnose, treat, and prevent disease. With unprecedented speed, researchers have used HapMap-enabled genome-wide association studies (GWAS) to identify a stunning number — over 130 in 2008 alone — of genetic factors associated with major causes of morbidity and mortality in the United States, such as diabetes, cardiovascular disease, lung and prostate cancer, and inflammatory bowel disease. Three recent GWAS of lung cancer have implicated genes related to nicotine addiction in disease causation, underscoring the possibility of genetic interactions with one of the strongest known environmental risk factors for lung cancer - cigarette smoking. Identification of gene variants associated with disease raises the possibility of using genetic testing, in combination with family history information, to identify susceptible, pre-symptomatic subjects for screening and preventive therapies.
Fueling the swift pace of genomic discoveries is NHGRI's continuing commitment to the development of innovative sequencing technologies, which reduces the cost and increase the speed of DNA sequencing. In the past decade, sequencing costs have decreased more than 50-fold, in part because the HGP delivered – beyond the complete DNA sequence – a wealth of tools, technologies, and process improvements. In FY 2008, the Institute supported investigators to develop near-term technologies to sequence a mammalian-sized genome for $100,000 and longer-term, revolutionary technologies to sequence a mammalian-sized genome for $1,000 or less. Excellent progress is expected toward achieving both goals by the year 2014. Importantly, the $1,000 Genome would enable health care professionals to personalize prediction, diagnosis, treatment, and preemption of disease to each person's unique genetic profile by bringing DNA sequencing into a cost-effective range for clinical use.
The Cancer Genome Atlas (TCGA), initiated in FY 2007, applies a comprehensive, large-scale genomic analysis approach to cancer research. It is jointly supported and led by the NHGRI and the National Cancer Institute (NCI) and completed its pilot phase in FY 2009. In FY 2008, the first results of this project were obtained for the most common form of brain cancer, glioblastoma multiforme (GBM). Among other important findings, the research identified a potential mechanism of resistance to a common chemotherapy drug used for brain cancer. These first results from the TCGA pilot project represent an exciting new discovery and provide proof of concept about the value of thismulti-dimensional analysis of the molecular characteristics of cancer in humans. The NHGRI will continue to support, independently, additional cancer research through the Tumor Sequencing Project, which will support comparable analysis of large-scale identification of genomic changes in different tumor types.
An important clinical program, launched in 2008, the UDP aims to provide answers to patients with mysterious conditions that have eluded diagnosis, through the conduct of an intensive review and analysis by a multi-disciplinary team of experts. The UDP is jointly led by the NHGRI, the NIH Clinical Center, and the Office of Rare Diseases Research and focuses on the most puzzling medical cases referred to the NIH by physicians across the nation.
Two clinical genomics initiatives launched in FY 2007 are now in full stride. The first, ClinSeq, is a pilot study aimed at developing the technologic and procedural infrastructure to facilitate large-scale medical sequencing in a clinical research setting. The second, the Multiplex Initiative, is a research study intended to provide genetic susceptibility testing for several common health conditions, such as cardiovascular disease and osteoporosis, and to evaluate patients' reactions to the testing and receipt of results.
Full realization of the potential of genomic medicine requires a multi-pronged approach that includes not only basic science advances, but also health applications research, the education of health professionals and the public, and community involvement in the analysis and interpretation of the complex ethical, legal, and social issues raised by this powerful new level of knowledge about each of us as individuals.
Overall Budget Policy: The NHGRI will continue to support new investigators and to maintain an adequate number of competing RPGs. In order to maximize the number of competing RPGs that can be made, NHGRI's review and approval funding process will follow the NIH budget policy in providing 2.0 percent inflationary increases for non-competing and competing grants. Investigator-initiated research projects and new investigator research and career development are among the Institute's highest priorities. The NHGRI carefully evaluates investigator-initiated requests to submit grant applications for all large programs. The Institute maintains a balance between solicitations issued to the extramural community in areas that need stimulation and funding made available to support investigator-initiated projects. Intramural Research and Research Management and Support receive an increase in FY 2010 to help cover the cost of pay and other increases.
Program Descriptions and Accomplishments
Basic Genomics
One of the primary objectives of contemporary biomedical research is to define and understand how the human genome functions, how misfunction leads to disease, and how that knowledge can be used to develop new preventative strategy, diagnostic methods, and therapies. Comparison of the genome sequence of humans with that of other organisms identifies regions of similarity and difference, providing insight into the evolution, structure, and function of human genes and pointing to new strategies to combat human disease. Therefore, genome sequencing of multiple non-human species as a window into the human genome remains an important approach to biomedical research and a priority for the NHGRI.
Currently, 197 genomes are either in the pipeline or have been completed by the NHGRI. In FY 2008, one of the most interesting genomic sequences completed was that of the duck-billed platypus, which provided new clues on how fundamental mammalian biological processes have evolved. Ongoing sequencing targets include several more non-human primates, additional mammals, fungi, and multiple strains of yeast. The NHGRI funds this work by supporting three large-scale sequencing centers that are world leaders and renowned for their cost effective and high quality work.
Budget Policy: The FY 2010 budget estimate for large-scale sequencing (non-medical) is $25.000 million, a decrease of $10.000 million or 28.6 percent from the FY 2009 Estimate. This decrease represents a continuation of on-going reprioritization and is balanced by increases in the Medical Sequencing and The Cancer Genome Atlas large-scale sequencing components (see below), so that the total amount of NHGRI spending on large-scale sequencing will remain constant. FY 2010 will be the year in which the on-going major transition in sequencing technology will be fully implemented. The capillary gel electrophoresis-based sequencing instruments previously used to sequence the human genome will be supplanted with a mix of sequencing approaches dominated by the new, next-generation single molecule-based sequencing instruments (that were developed with a significant amount of support from the NHGRI Sequencing Technology Program, a prime example of public-private partnership and economic development directly attributable to NIH funding). One effect of implementation of the "'next-gen" technologies will be a significant increase in the overall capacity of the NHGRI Sequencing Program. This will allow the Institute to increase the amount of sequence data generated in the Large-Scale Sequencing (Non-Medical) component while decreasing the amount of funding dedicated to that area. At the same time, the Institute will be able to devote a larger proportion of the overall large-scale sequencing effort in FY 2010 to projects directed toward understanding disease, specifically, Medical Sequencing (see below) and The Cancer Genome Atlas (see below). The activity in the Large-Scale Sequencing (Non-Medical) component will continue the NHGRI's signature efforts to generate the genomic sequence data from many sources that are needed to reveal the functional components of the human genome.
Seven studies are currently underway to identify the genes responsible for several relatively rare, "single-gene" diseases and to survey the range of gene variants that contribute to certain common diseases. In FY 2008, a number of additional medical sequencing projects were initiated:
Budget Policy: The FY 2010 budget estimate for medical sequencing is $64.766 million, an increase of $5.000 million or 8.4 percent over the FY 2009 Estimate. Medical sequencing continues to be an area of growth for the NHGRI. With the introduction of next-generation sequencing instruments on a production scale, many new opportunities have been created to apply genomic tools to the study of human disease and the application of that information to the development of new approaches to disease management. In FY 2010, the NHGRI will continue the increase of funds that the Institute spends on the Medical Sequencing component of its Large-Scale Sequencing program.
Another component of the NHGRI Cancer Sequencing Program is a collaborative effort among the NHGRI large-scale sequencing centers and cancer biology experts studying lung adenocarcinoma. In FY 2007, this group used comprehensive genomic analysis to reveal previously unknown genes that play an important role in that form of cancer, and on-going efforts have continued to reveal more information about the genomics of lung cancer.
Budget Policy: The FY 2010 budget estimate for TCGA is $22.500 million, an increase of $5.450 million or 32.0 percent over the FY 2009 Enacted. In its pilot phase, the TCGA has met many of its original objectives, most importantly the demonstration of the feasibility and value of a genomic analysis of the genomes of specific tumor types.
The NHGRI supports research to identify and characterize the function of all parts of our genome and to understand their biological relevance. Efforts to uncover functional elements are not limited to the human genome, since understanding the genomes of other, "model," organisms can also give insight into the structure and function of the human genome.
Launched in FY 2003 as a pilot, the ENCyclopedia of DNA Elements (ENCODE) Project successfully demonstrated its ability to provide important information about the structure and function of 1 percent of the human genome. In FY 2007, the NHGRI implemented a full-scale ENCODE Project to examine the entire human genome for sequence-based functional elements, and initiated modENCODE, which has similar goals for the analysis of the genomes of two important model organisms. The NHGRI has supported two trans-NIH initiatives to develop publicly available resources critical to accelerating research on genomic function: 1) the Mammalian Gene Collection (MGC), which successfully obtained full-length clones for every human and mouse gene, completed in FY 2008; and 2) the Knockout Mouse Project (KOMP), a collaboration with European and Canadian groups that seeks to produce a mutation in every mouse gene.
Budget Policy: The FY 2010 budget estimate for Genomic Function programs is $61.602 million, an increase of $1.208 million or 2.0 percent from the FY 2009 Estimate. Activity in Genomic Function will remain essentially constant, maintaining the proportion of the NHGRI extramural budget devoted to this area. It should be noted, however, that this is another area in which the introduction of next-generation sequencing technology will enable a significant increase in the amount of data generated without an increase in cost. The Institute also will continue to fund meritorious investigator-initiated applications submitted in response to announcements that encourage new technologies and new approaches to the analysis of genomic function.
Although the genome sequence variation between two people is less than one percent, this tiny difference underlies a variety of observable characteristics ranging from the benign, such as hair or eye color, to disease, such as diabetes, cancer, Alzheimer's, or heart disease. The NHGRI-led International HapMap Project charted the common patterns of genetic variation in the world's population by identifying and cataloging single letter spelling variations in our genome's alphabet, referred to as single nucleotide polymorphisms, or SNPs. The goal of the HapMap is to provide the resource necessary to identify disease-causing variants with the potential of using these discoveries to develop treatments.
In FY 2007, the promise of the HapMap as an unparalleled resource for human genetics was dramatically realized, with the identification of a host of new genes involved in a number of common diseases. Additionally, the second generation haplotype map, Phase II HapMap, was completed and published in FY 2007. At three times the resolution of the original, Phase II has facilitated many new studies to investigate the link between genetic variation and other factors involved in health and disease, including susceptibility to infection, response to environmental factors, and drug efficacy. In FY 2008, the NHGRI initiated the 1000 Genomes Project to obtain an even more complete catalogue of human sequence variation by using new and more cost-effective sequencing technologies to sequence the genomes of approximately 1000 individuals.
Budget Policy: The FY 2010 budget estimate for Genomic Variation programs is $14.669 million, an increase of $287 thousand or 2.0 percent over the FY 2009 Estimate. Activity in Genomic Variation will remain essentially constant, maintaining the proportion of the NHGRI extramural budget devoted to this area. However, emphasis within this program will shift to the analysis of the data generated in the 1000 Genomes Project. The NHGRI will also continue support of the effort, which began in FY 2006, to analyze structural variation in the human genome and to determine the contribution of structural variants to human diseases. The Institute also will continue to fund meritorious investigator-initiated applications submitted in response to announcements that encourage new technologies and new approaches to the analysis of genetic variation, and the role that genetic variation plays in the determination of human disease, disease susceptibility, and environmental sensitivities.
FY 2009 Level: $15.000 million
FY 2010 Level: $7.500 million
Change - $7.500 million
The 1000 Genomes Project is an ambitious effort to sequence the genomes of at least a thousand people from around the world to create the most detailed and medically useful picture ever of human genetic variation. The new genomes will provide a view of biomedically relevant DNA variations at a resolution unmatched by current resources. Researchers will use the catalog developed by the project for many future studies of people with particular diseases. Data from the 1000 Genomes Project will be swiftly available to the scientific community through freely accessible public databases, while simultaneously ensuring participant privacy and protection.
The 1000 Genomes Project builds on the human haplotype map developed by the International HapMap Project, but will provide a much more comprehensive view. It aims to find almost all the variants in the genome, including those that contribute to disease risk. The 1000 Genomes Project will map not only the single-letter differences in people's DNA, called single nucleotide polymorphisms (SNPs), but also will produce a high-resolution map of larger differences in genome structure called structural variants, which are rearrangements, insertions, deletions, or duplications of DNA segments. The importance of these variants has become increasingly clear with surveys completed in the past 18 months that show these differences in genome structure may play a role in susceptibility to such conditions as mental retardation and autism.
The project includes large-scale implementation of several new sequencing platforms. Using standard DNA sequencing technologies, the effort would likely cost more than $500 million. However, the cost is expected to be far lower — $30 million to $50 million — due to the project's pioneering use of new sequencing technologies.
As the speed of genotyping and DNA sequencing increase (accompanied by a continued decrease in their costs), the rate of data production will increase even more rapidly. The NHGRI supports a number of efforts in computational genomics research to continue development of database technology and computational methods critical to genome-wide studies.
The NHGRI will continue its support for genomic databases, an essential resource utilized worldwide to accelerate biomedical research. Ongoing and planned program announcements encourage development of new technologies and new approaches to the emerging issue of how to make the enormous amount of data generated by large-scale, genomic studies available to the broad research community and how to analyze such large datasets.
Budget Policy: The FY 2010 budget estimate for Computational Genomics programs is $47.014 million, a change of $628 thousand or 1.4 percent over the FY 2009 Estimate. Activity in Computational Genomics will remain essentially constant, maintaining the proportion of the NHGRI extramural budget devoted to this area. In FY 2010, the NHGRI will continue its support for the essential biomedical research resource represented by genomic databases. The Institute also will continue to fund meritorious investigator-initiated applications submitted in response to announcements that encourage new technologies and new approaches to the rapidly emerging issue of public access to large genomic datasets.
The mission of the NHGRI's technology development programs is to make DNA sequencing and other genomic analyses faster and more cost effective for use in both medical research and health care. The cost of DNA sequencing has fallen dramatically, more than 50-fold, over the past decade and continues to fall. The ability to sequence an individual genome inexpensively would not only further biomedical research, but would enable health care professionals to tailor diagnosis, treatment, and prevention strategies to each person's own genetic profile.
The NHGRI-supported grants were instrumental in the development of three new sequencing instruments now on the market and one more nearing market introduction. In addition, three firms that have pioneered development of new sequencing technologies have recently joined the international effort to build the most detailed map to date of human genetic variation as a tool for medical research, the 1000 Genomes Project (see above).
Grants supporting the creation of novel tools and technologies show promise to reduce further the cost of sequencing a human-sized genome, from the cost of ~$10 million within the past two years to $100,000 within the next two years. Another set of more than two dozen grants fund investigators who are developing breakthrough technologies that should make it possible to sequence a human genome for $1,000 within several years. In FY 2008, the NHGRI funded eight investigator teams to develop revolutionary technologies that would make it possible to sequence a genome for $1,000 or less, as well as three investigators developing nearer-term technologies to sequence a genome for $100,000.
Budget Policy: The FY 2010 budget estimate for technology development is $48.485 million, an increase of $951 thousand or 2.0 percent over the FY 2009 Estimate. The NHGRI will continue in FY 2010 its ground-breaking efforts to reduce the cost of DNA sequencing to the point at which the technology will be a widely disseminated research tool and a tool for individual healthcare. The Institute also will continue to fund meritorious investigator-initiated applications submitted in response to announcements that encourage the development of new technologies for biomedical and translational research.
FY 2009 Level: $22.436 million
FY 2010 Level: $24.212 million
Change +1.776 million
DNA sequencing costs have fallen dramatically over the past decade, fueled in large part by tools, technologies, and process improvements developed as part of the successful effort to sequence the human genome. Subsequently, the NHGRI launched programs to accelerate the development of sequencing technologies. Significant progress has been made towards the goal of producing high quality whole genome sequence for $100,000. The NHGRI's ultimate vision is to cut the cost of whole-genome sequencing of an individual's genome to $1,000 or less, which will enable sequencing as part of routine medical care. The imperative to collect large numbers of additional genome sequences is strong, but the cost has been much too high, motivating this technology-development thrust. The NHGRI is committed to medical sequencing for transitional "bench to bedside" applications – to establish links between specific changes in gene sequence and the many diseases that affect humans. The ability to sequence an individual genome inexpensively would not only further biomedical research, but also enable health care professionals to tailor diagnosis, treatment, and prevention strategies to each person's own genetic profile.
NHGRI-supported grants were instrumental in the development of three of the four new sequencing systems that recently reached the market. In FY 2008 alone, the NHGRI awarded more than $20 million in grants to develop innovative sequencing technologies inexpensive and efficient enough to sequence a person's DNA as a routine part of biomedical research and health care. Substantial technical advances stimulated by the first five years of investment may enable commercialization of yet another generation of sequencing systems in less than five years, to achieve the $1000 genome goal.
Multi-investigator, interdisciplinary research teams are crucial to develop novel and innovative genomic research projects and to foster the wider application of comprehensive, high-throughput genomics methods to the study of human biology and disease, using and expanding the data sets and technologies developed by the Human Genome Project.
Started in FY 2001, the NHGRI's Centers of Excellence in Genomic Science (CEGS) program supports the formation of such teams and also provides focal points for providing education and training about genomic research opportunities to members of under-represented population groups. In FY 2007, the NHGRI announced grants to establish a new CEGS focused on viral infections and renew support of a CEGS studying vertebrate diversity.
Budget Policy: The FY 2010 budget estimate for other basic genomics programs is $54.225 million, an increase of $91 thousand or 0.2 percent over the FY 2009 Estimate. In FY 2010, the NHGRI will continue to support the CEGS program in its efforts to stimulate highly innovative research approaches that will substantially advance genomic approaches to the study of a biological problem, and to foster the wider application of comprehensive, high-throughput genomics methods to the study of human biology and disease. The Institute will also continue to fund meritorious investigator-initiated applications that will increase the ability of genomics to have a major impact on the progress of biomedical and translational research.
The NHGRI is strongly committed to translating the information gleaned from studies of genomic function and variation into clinical applications. Diseases arise from a complex interplay between genes and environment; therefore, DNA variations, epigenetic factors, and external factors acting "on" the genome must all be considered in diagnosing and treating patients. Understanding this interplay will truly revolutionize our approach to health and health care, allowing not only much more accurate prediction of disease, but, ultimately, individual-based disease prevention.
In FY 2007, the initial projects of the Genes, Environment and Health Initiative (GEI), a collaboration with the National Institute for Environmental Health Sciences (NIEHS), were funded to identify and understand the interactions of environmental exposures with specific genetic variation. These included eight genome-wide association studies (focusing on addiction, birth weight, coronary heart disease, dental caries, lung cancer, oral clefts, prematurity and type 2 diabetes), two genotyping centers, a coordinating center, and more than 30 environmental technology projects. Another "bench to bedside" translational research project is an innovative study, in collaboration with the National Heart, Lung and Blood Institute (NHLBI), to evaluate the use of genetic variants to personalize the dosing of a commonly-used and potentially risky medication, Coumadin.
In FY 2008, the NHGRI announced grants expected to total about $31.000 million over the next four years for research aimed at gaining a better understanding of how specific genetic variants act to influence the risk of diabetes, heart disease, cancer and other common diseases. Scientists have already discovered more than 25 genetic variants in 18 genes connected to cholesterol and lipid levels.
Budget Policy:The FY 2010 budget estimate for translational genomics is $25.516 million, an increase of $909 thousand or 3.7 percent over the FY 2009 Estimate. The NHGRI is continuing to expand activity in the area of translational genomics, as the application of advances in genomics to problems of human health has a very high programmatic priority.
As the use of genetics and genomics in translational and clinical studies increases, the importance of addressing the ethical, legal, and social implications (ELSI) of the results of genetic and genomic research continues to grow as well. The NHGRI addresses such issues through its ELSI Research Program and through public consultation and community engagement that identifies and responds to culturally specific concerns and gives participating communities input into research, importantly including the informed consent and sample collection processes.
In FY 2004, the NHGRI launched an initiative to address the challenges of ELSI research related to the use of genetics and genomics in translational and clinical studies, the Centers of Excellence in ELSI Research (CEERs) program. The CEERs are charged with: 1) fostering the multi-disciplinary approaches necessary to make advances in understanding the issues that will be raised by progress in genomic science, 2) conducting ELSI research to inform the development of research, health, and public policies and practices and, 3) training the next generation of ELSI researchers. In FY 2008, the NHGRI established two new centers focused on the ELSI issues surrounding large-scale genomics research and emerging genetic technologies.
Budget Policy: The FY 2010 budget estimate for the ELSI program is $19.146 million, an increase of $777 thousand or 4.2 percent over the FY 2009 Estimate. The ELSI budget is legislatively mandated at 5.0 percent of the total NHGRI extramural budget. In FY 2010, the NHGRI will continue to support the ELSI research program in its efforts to anticipate and address the social, legal, and ethical issues that will arise from new information about the human genome and the genetic contribution to human disease, and new approaches to applying that information to the improvement of human health.
NHGRI intramural researchers continue to focus on the genetic components of both rare and common disorders. As an example, a team of researchers led by NHGRI investigators recently completed the most comprehensive look to date at genetic risk factors for type 2 diabetes, identifying at least four new genetic variants associated with increased risk of diabetes and confirmed existence of another six. These findings boosted to at least ten the number of genetic variants confidently associated with increased susceptibility to type 2 diabetes — a disease that affects more than 200 million people worldwide. These investigators are now using contemporary genomics technologies, including powerful new methods for sequencing DNA, to identify the specific variants causing the increased risk for diabetes; this should yield new insights into the disease that may lead to new therapeutic avenues. Other research performed within the institute continues to have a profound impact on our understanding of more rare genetic disorders.
The NHGRI Division of Intramural Research plans to continue increasing its focus on translational research in FY 2010. The recently established Office of Translational Research, which is intended to encourage collaborations between basic scientists and clinical investigators, is already facilitating the translation of promising laboratory discoveries into clinical research studies. One notable advance in this area is the recent launching of a transdisciplinary program to characterize fully the complete set of microbes growing on human skin (the skin microbiome). This project is capitalizing on powerful new genomic technologies that allow detection of microbes that otherwise cannot be grown in the laboratory; these microbes are highly relevant to human health and to skin diseases.
Two clinical genomics initiatives launched in FY 2007 are now in full stride. The first, called ClinSeq, is a pilot study aimed at developing the technologic and procedural infrastructure to facilitate large-scale medical sequencing in a clinical research setting. The second, called the Multiplex Initiative, is a research study intended to provide and evaluate patients' reactions to genetic susceptibility testing for several common health conditions, such as cardiovascular disease and osteoporosis. These initiatives are providing a foundation for studies in genetic-based personalized medicine, an area that is becoming increasingly important in light of the proliferation of direct-to-consumer genetic testing services.
In FY 2008, the NIH launched the Undiagnosed Diseases Program (UDP) — a clinical research program that aims to provide answers to patients with mysterious conditions that have long eluded diagnosis. Representing a partnership between the NIH Office of Rare Diseases Research and the NHGRI, but involving dozens of health professionals at the NIH Clinical Center, the initiative focuses on the most puzzling medical cases referred to the NIH by physicians across the nation. Nearly 1,000 inquires have already been evaluated for potential participation in the program. More than 25 patients were enrolled in the program in FY 2008.
In FY 2008, the NHGRI Intramural Program recruited a world-class African-American researcher who studies the genetics and genomics of health disparities. He is the founding Director of the Center for Research on Genomics and Global Health, a new trans-NIH research entity that opened in the third quarter of FY 2008.
Budget Policy: The FY 2010 budget estimate for Intramural Research is $104.148 million, an increase of $1.539 million or 1.5 percent over the FY 2009 Estimate. This increase involves four areas.
- The recruitment of new Tenure-Track Investigators that will arrive at the end of FY 2009 following rigorous searches and recruitments.
- The addition of personnel to strengthen our translational and clinical research programs. This will include the recruitment of additional physician-scientists and other health professionals with expertise in clinical research, including some who will join the Office of Translational Research. It also includes continued growth of our flagship intramural clinical genomics projects, ClinSeq and Multiplex. Also, significant personnel growth will occur to support the recently launched Undiagnosed Diseases Program.
- Continued acquisition and implementation of new technologies for performing large-scale DNA sequencing. Genomics is currently seeing major growth in terms of new methods for obtaining very large amounts of DNA sequence data at lower and lower costs. The NHGRI Intramural Program will continue to implement these powerful 'next-generation' DNA sequencing technologies in FY 2010, along with the accompanying bioinformatics and computational infrastructure that they require. These new technologies are increasingly being applied to clinical research projects.
- Continued growth of our chemical genomics program, with its world-class expertise and experience in high-throughput screening of chemicals for biological function. These efforts include expansion into the study of inhibitory RNA molecules, and will increasingly involve both basic and clinical research applications.
The NHGRI's Office of the Director, part of the RMS program, oversees the operation of the institute and includes a number of component parts. Major ongoing initiatives for which the Office of the Director provides key leadership and financial support include National DNA Day, the U.S. Surgeon General's Family History Initiative, and the development of genetics education resources for health professionals. DNA Day is an annual opportunity to educate students about genetics and genomics and to use this cutting edge field to spark their interest in science. The NHGRI staff collaborates with researchers, advocacy organizations (both professional and lay), and educators from formal and informal education institutions to reach students across the country. Outreach is achieved through classroom visits, professional development opportunities for educators, and a live web-based chatroom where students can post questions to the NHGRI researchers and staff that are answered in real-time. The U.S. Surgeon General's Family History Initiative is a coordinated multi-agency effort to encourage all American families to learn more about their family health history and to employ it in preventive health care. To make gathering this information easier, an improved version of the online web based tool, "My Family Health Portrait," as well as paper versions of the tool have been made available for download. To expand the initiative's reach and public benefit, the NHGRI continues to collaborate across federal agencies to enhance the family history tool's capabilities and to engage in demonstration projects to develop evidence regarding the tool's utility. Projects to promote the public's awareness and participation in the initiative will also be pursued. Finally, the NHGRI is taking a leadership role in facilitating the development, pilot testing, and dissemination of interdisciplinary web-based genetics educational resources for health professional groups, as well as community-based and public health organizations.
Budget Policy: The FY 2010 budget estimate for research management and support is $22.524 million, an increase of $387 thousand or 1.7 percent over the FY 2009 Estimate. In FY 2010, the NHGRI plans to continue to develop ongoing initiatives for which the Office of the Director provides leadership and financial support. Such programs within the Office of Policy, Communication, and Education include National DNA Day, the U.S. Surgeon General's Family History Initiative, and the development of genetics education resources for health professionals. In addition, the NHGRI is enhancing the Risk Management Program, which includes business process reengineering, setting up new procedures and tools to ensure our continued prudent use of RMS funds. RMS funds will be used to continue funding the activities mentioned above to support the infrastructure that allows the NHGRI to pursue and achieve its mission.
The NHGRI is the lead Institute for the Connectivity Map supported through the NIH Common Fund. In addition, the NHGRI is a co-lead for the Molecular Libraries initiatives, including:
Finally, the NHGRI also co-leads the new Human Microbiome Project, also supported through the NIH Common Fund.
Last Reviewed: May 19, 2012


text:
Internationalized Domains
All Domain Prices
Contact Us
Terms of Use
Enter your desired domain name and click search to see if it is
Register your Algerian domain name with domainsrus.net
today and take advantage of savings for multi-year registrations.
read about the pricing, registration requirements, and registration
timeframe for .dz below.
This domain is not available to the public for registration
Companies or legal entities may apply. Registrant must have trademark registration or application (including registration forms) designating Algeria. -OR- Send a copy of your Algerian company incorporation. Domain name must be related to trademark or company name. Main nameservers must be located in Algeria, we can provide this service.
1 Month

subset: commoncrawl


text:
U.S. Equal Employment Opportunity Commission
Panels of Speakers and Informational Fair Commemorate Equal Pay Day at Agency
WASHINGTON—Gender-based wage discrimination remains a problem today and a percentage of the wage discrepancy cannot be explained by non-discriminatory factors, said government and private experts at a public forum held today at the headquarters of the U.S. Equal Employment Opportunity Commission (EEOC).
The forum was one of 24 such events the EEOC is sponsoring across the country during April and May to raise awareness of the problem of wage discrimination and to educate the public. The Commission is a key member of the National Equal Pay Enforcement Task Force, launched by President Obama to "improve compliance, public education, and enforcement of equal pay laws." The headquarters event featured leaders from other Task Force members including the Departments of Justice and Labor, and the Office of Personnel Management.
"We have come a long way since the days when gender-based inequities in access to jobs and payment of wages were sanctioned by law, but studies show that a significant portion of the wage disparity cannot be explained by differences in experience, specific work performed, education or other non-discriminatory factors," said EEOC Chair Jacqueline A. Berrien. "This persistent disparity is a stark reminder that the EEOC's work to end every form of sex discrimination in the workplace -- including compensation discrimination -- is still unfinished business."
In addition to Chair Berrien, the following government experts presented their agencies' particular perspectives on the issue of wage discrimination: Thomas Perez, Assistant Attorney General for Civil Rights at the Department of Justice; Sara Manzano-Diaz, Director of the Women's Bureau, U.S. Department of Labor (DOL); Patricia Shiu, Director of the Office of Federal Contract Compliance Programs (OFCCP), DOL; Nancy J. Leppink, Acting Administrator of the Wage & Hour Division, DOL; and Christine Griffin, Deputy Director, Office of Personnel Management.
Sara Manzano-Diaz of the Women's Bureau -- which celebrated the 90th anniversary of its founding last year -- said that from its inception the Bureau had as one of its main purposes the equalization of wages between women and men. Patricia Shiu, head of the OFCCP, told the audience of approximately 125 people that closing the wage gap is not just a civil rights issue, but an American recovery issue. All the government leaders stressed the value of the inter-agency cooperation that has resulted from the national Task Force.
Katherine M. Kimpel, a partner in the law firm Sanford Wittels & Heisler, kicked off the second panel by stating that if women think they are being paid equitably in their jobs, unless they have looked at the relevant data, the likelihood is that they are not. She said that many times women had come to consult her about other discrimination issues, insisting that pay was not a problem, only to find out later that they were being underpaid.
Serena Fong of Catalyst, a nonprofit membership organization dedicated to expanding opportunities for women in business, said that there is a gender leadership gap as well as a pay gap. She noted that over 98 percent of Fortune 500 companies have male CEOs, and that the salary studies conducted by Catalyst show that women at these companies start off with salaries $4,600 less than men, even accounting for differences in education and experience.
Cecelie Counts, the legislative representative of the AFL-CIO, told the group that it's important not to forget the lowest wage earners -- day care workers, cleaners, aides -- for whom the wage gap has an even more pronounced impact. According to Lisa Maatz, Director of Public Policy and Government Relations of the American Association for University Women (AAUW), one way to try to combat the wage gap is through legislation. She regretted the failure of the Paycheck Fairness Act to pass during the last Congress, but noted that the bill had been reintroduced in the Senate and House.
Following the formal presentations, audience members attended an informational fair with materials provided by a variety of organizations, including the Society of Human Resource Management; the National Partnership of Women and Families; the National Committee on Pay Equity; the District of Columbia Office of Human Rights; and Mana, a national Latina organization.
The EEOC enforces federal laws prohibiting employment discrimination. More information is available at www.eeoc.gov.


text:
Budget at a Glance
Publication/Part - HTML
PDF Download
Budget at a Glance is an overview of key budget aggregates and the Government's budget priorities.
If www.budget.gov.au responds slowly or you are having trouble downloading a document, try one of the Budget Website Mirrors
Note: Where possible, Budget documents are available in HTML and for downloading in Portable Document Format(PDF). If you require further information on any of the tables or charts on this website, please contact Treasury.


text:
The following press release came out of the governor's office:
On Thursday evening, Governor Dannel P. Malloy and Lt. Governor Nancy Wyman will host a community forum in New Britain, where they will speak with members of the public on the state's pressing issues. This will be the second event of this series of community forums.
WHO: Governor Malloy, Lt. Governor Wyman
WHAT: Governor Malloy & Lt. Governor Wyman host a community forum
WHEN: Thursday, March 14, 2013; 7:00-8:00 p.m.
WHERE: New Britain High School, Anthony Tercyak Lecture Hall; 110 Mill Street, New Britain


text:
Latest Diablo 3 News
DiabloWiki Updates
Support the site! Become a Diablo: IncGamers PAL - Remove ads and more!
Barbarians Chopper
View Larger Image
Barbarians Chopper
Fan Art by Ya Lee (Lee337)
D3 Fan Creations Forum Moderator
See all User Photos
Registered: July 2008
Location: Kansas
Posts: 3,229
Linked Thumb:
Linked Medium:
Medium Image:
Date: 11 August 2012
Views: 3,838
Dimensions: 3000 x 2445
Keywords: diablo 3 barbarian axe fallen lee337
Photo Sharing Gallery by PhotoPost
Copyright © 2014 All Enthusiast, Inc.
Copyright © 2014 All Enthusiast, Inc.


text:
100% Whole Grain Goodness and Fiasco. A tale of two cities.
I put my new grain mill to work this weekend. The first thing I did was bake the teaching loaf in Reinhart's Whole Grain Breads book. Note, the master formula is not error free. Under ingredients and method he states to use all of the soaker, and then states use all of the soaker (or biga) when he should have said starter (or biga). See, I read these things, Peter!
More substantively, the master formula states to chop the soaker and the starter or biga into 12 pieces each and to "sprinkle some of the extra flour over the pre-doughs to keep the pieces from sticking back to each other."
What am I missing, here? Why would you flour the pieces to prevent them from sticking if the goal is to mix the 24 pieces and combine them into a uniform mass? Seems that flouring the pieces is counterproductive.
Anyway, back to the story.
The mill:
The just-combined dough:
The bulk rise:
In the pan -- you can see the pan was a bit too small to contain the dough:
The bakes loaf:
The crumb (this is my PB&J sandwich. It is a little wet with jelly to the right of middle:
Overall, I am not thrilled with the bread I baked. It tastes fine and is not heavy. But it is also a bit too crumbly. It is difficult to slice thin and when sliced sandwich thickness, it does not hold up very well.
That said, I assume that this is the fault of the baker and not the formula. Although, if those who make this loaf regularly tell me that the bread is always easily torn and this is the best you can hope for from whole-grain goodness, my expectations can be adjusted.
After baking the sandwich loaf, I went back to Tartine and looked at his whole wheat recipe. That formula and instruction set is fundamentally flawed and I can't even figure out what is supposed to be done with it, because while he says the whole wheat requires extra hydration, he does not give a formula for 100% whole wheat, leaving me wondering how much extra hydration is needed if I decide to go 100% whole wheat.
It is flawed for a second reason also -- whereas the basic country loaf discusses 750 grams (50 grams reserved to add with the salt) of water, the whole wheat description mentions 800 grams of water, mentions nothing about a reserve, and tells you mix the dough and says nothing about when to add the salt (if I recall, it actually refers back to the basic country loaf, but has you starting after the salt has been added).
Anyway, I figured if 800 grams was used with 800 grams of whole wheat, then I should add more than 800 for 100% whole wheat. However, using 845 grams produced a dough that was rather wet.
I autholyzed overnight at room temperature, added the leaven and let it bulk ferment for 4 hours at 70 degrees. The dough was bubbling at the surface. But it was very wet. I did not know whether I should shape it or let it sit longer. So I shaped it. Unfortunately, it was too loose and so I followed his directions after seeing a too runny bench rest and did another pre-shape. This time it held together much better, so I finished the shaping and added it to my basket.
After proofing for 3 hours, it rose considerably but it had the consistency of Jell-O and did not look like it would make it out of the basket.
To my surprise, I successfully predicted that the dough would not come out of the basket. No way, no how. It was stuck good what I was able to tear out, was a big gloppy mess.
I baked it anyway. I am afraid to cut it.
It came out like a dense rock. I didn't bother scoring it because the "it" was not really a loaf.
I am ashamed to have wasted so much flour. I don't know if my 86% hydrated dough was the problem or if I should have let it sit overnight in the fridge to let it dry out. Unfortunately, I am not yet "there" with knowing whether dough is overproofed and I was a little concerned that leaving it for too long in its whole wheat state, would result in overproofed dough -- especially when I was seeing bubbles at the surface after only a few hours.
I also made whole wheat pizza with the other half of the dough (with 1/2 of that, still in the fridge). The pizza was chewy and not bad, but not nearly as good as the tartine basic country loaf with white flour. In part, it was not a fair test because I did not cook it on a preheated pan, but it was just too wet and stretchy to bake it that way and instead I dropped the goopy dough into the rectangular pan, stretched it out a bit and baked it in a hot oven.


text:
Africa (2007-2011)
I first visited Africa in 2005 and have been back a number of times since. I bought my first DSLR in 2006 and took it to Namibia in 2007. This is a mix of shots from my trips that I personally like for one reason or another. Whether or not you enjoy looking at these, you can be sure that I enjoyed taking them!Read More
20 / 238


text:
Qualifying Conditions and FAQs
I. Amendments Subject to PRC Review
LCCC Investigator Initiated studies:
- Adding a new drug to patient treatment or adding another treatment/treatment arm (ex. radiation, surgery, etc.)
- Changing the primary objective of the study
- Adding or subtracting an element from the study that changes the statistics (please include statistician signoff with amendment review application)
Please note:
If your study is run under an IND, submission of this amendment to the FDA may be required, per 21CFR312.30 (b). Please review the following criteria and submit accordingly.
Pharmaceutical, NCI, or Other Institution studies:
- Adding a new drug to patient treatment or adding another treatment/treatment arm (ex. radiation, surgery, etc.)
- Changing the primary objective of the study
II. FAQs
- To which studies do the amendments apply?
Amendment regulations will apply to LCCC and Pharmaceutical studies but not Cooperative Group. Both CPO and Non-CPO studies are included.
- What is the effective date for this process?
Amendment review procedures are effective October 1st, 2007.
- What is the procedure for submitting amendments?
Submissions should be made to the PRC Coordinator directly via email. Please include the Amendment with cover sheet delineating all changes to protocol and any new or revised consent forms reflecting the changes to the study.
For amendments which affect the statistics of the study, please include a new biostatistician signoff form indicating review and approval of the statistics by the statistician of record for the study.
- What would be the PRC action and how will we receive comments?
Amendments will be reviewed administratively by the PRC Chair (except studies for which the PRC Chair is involved to be reviewed by the Co-Chair). If an amendment is approved then a letter will be issued to that effect by the PRC Coordinator. If the study requires further review (as determined by the PRC Chair) it will receive a full PRC review and be placed on the next available PRC agenda.
Studies for which only statistics have been affected will receive review by a PRC statistician. If determined to need full review by the statistician, the study will be placed on the next available PRC agenda.
- What is the rationale for requiring amendment reviews by PRC? How long will amendment review take?
Amendments which involve a substantive change to the science or safety of the protocol will be reviewed to ensure the continued safety and efficacy of studies conducted at UNC. As stated above, amendments requiring review will receive an administrative review by the PRC Chair, Co-Chair or statistician. The estimated response time is no more than two weeks from time of receipt, with most responses received in less than one business week. If a study requires full PRC review, it will be placed on the next available PRC agenda and receive a response one to two business days following the meeting.
Please address all submissions to:
Stacy Maxwell
Protocol Review Committee Coordinator
UNC Lineberger Comprehensive Cancer Center
3rd Floor CB #7295
Telephone: 919.962.8566


text:
Performance Space and Pony Express present
Pony Express
Tuesday 1 November, 6.30om - 10.30pm PREVIEW
Wednesday 2 November, 6.30pm – 10.30pm
Thursday 3 November, 6.30pm – 10.30pm (Tactile Tour & Audio Described Performance)
Friday 4 November, 6.30pm – 10.30pm
Saturday 5 November, 6.30pm – 10.30pm
*The Ecosexual Bathhouse experience invites patrons to discover and interact with a mixture of installations and performance interactions. Patrons can move through the bathhouse at their own pace and are free to engage in as much or as little activity as they desire. The average time the experience takes is 45 minutes.
"A hedonistic Eden for a post-sustainable age" Olivia Parkes, Vice Magazine
Ecosexual Bathhouse is an immersive experience inviting you to leave the urban wasteland behind and open yourself up to an intimate encounter with the biosphere. Perth-based artist collective Pony Express offer up a cave of wonder with a variety of eco-erotic experiences. Experiment with pollination, unwind in the sauna or be guided by a bathhouse regular toward your own organic awakening. Catering to all—from the mildly bio-curious to the environmentally experienced—we encourage you to embrace the Earth and give in to your budding naturist. Drawing on the Eco-sex manifesto by Annie Sprinkle and Dr Elizabeth Stephens, Ecosexual Bathhouse explores a radical environmentalism
where the political becomes very personal. The six awe-inspiring spaces of Ecosexual Bathhouse invite us to reconsider the relationship between humans and nature: because if we can learn to the love the Earth, then maybe we can save it.
Contains the use of pollen, organic materials and scent.
Contains adult content. Suitable for people 16 years and above.
Artists and Creators: Pony Express (Loren Kronemyer and Ian Sinclair)
Producer: Sarah Rowbottham
Production Manager: Emily O'Brien
*Please note there are very limited tickets per session. If you have trouble booking your group into one session you can either split the group over two session, or give the office a call on 02 8571 9111 and we will help you book.


text:
|A charter bus carrying the Bluffton University baseball team from Ohio is seen after it plunged off a highway ramp early Friday, March 2, 2007 in Atlanta and slammed into the I-75 pavement below killing at least six people. (AP Photo/Gene Blythe)
Team's bus falls off Ga. highway; 6 die
ATLANTA --A small college in Ohio was thrown into mourning Friday after a bus carrying the baseball team tumbled over the side of a highway overpass and slammed onto the pavement 30 feet below, killing four students, the driver and his wife.
The team from the close-knit, Mennonite-affiliated Bluffton University was making its annual spring training trip to Florida before daybreak when the charter bus crashed, scattering bags of baseball equipment across the road and splattering blood on the overpass. Some of the athletes climbed out the roof escape hatch, dazed and bloody.
"I just looked out and saw the road coming up at me. I remember the catcher tapping me on the head, telling me to get out because there was gas all over," said A.J. Ramthun, an 18-year-old second-baseman from Springfield, Ohio, who was asleep in a window seat and suffered a broken collarbone and cuts on his face from broken glass. "I heard some guys crying, `I'm stuck! I'm stuck!'"
Investigators said the driver apparently mistook an exit ramp for a lane and went into the curve at full speed. It was dark at the time, but the weather was clear.
On the 1,150-student campus in Bluffton, about 50 miles south of Toledo, students and community residents -- some wiping away tears -- filled the gymnasium to grieve and learn more about what happened. When news of the crash appeared on television, students desperately tried to reach some of the athletes on their cell phones.
Sophomore Courtney Minnich said that at a college as small as Bluffton, "even if you didn't know everybody, it will hurt, because you've seen them on campus."
Megan Barker, a sophomore, said she knew just about everyone on the team and described them as "a fun-loving group of guys." She added: "They live as a family."
Classes were canceled, along with other sports trips that had been scheduled during next week's spring break. A candlelight vigil was held Friday evening. Airlines also arranged for the players' parents to fly to Atlanta for free.
Cindy Perkins, of Convoy, said she looked forward to an emotional reunion with her son, Matt, who was badly bruised.
"That's probably going to be the tough part: just going through, reliving what happened and knowing that some of the friends he had, he won't be in contact with them anymore," she said.
Beyond the six killed, 28 players and their coach, James Grandey, 29, were taken to the hospital. He and six players were reported in serious or critical condition; many of the rest were soon released. The players' injuries included broken bones, cuts and bruises.
The bus had set out from Ohio the evening before and had traveled all night long before it went off the road and landed on its side about at about 5:30 a.m. on Interstate 75. Two vehicles under the overpass were struck by the bus, but their drivers were not hurt.
"It looked to me like a big slab of concrete falling down," said pickup-truck driver Danny Lloyd, 57, of Frostburg, Md. "I didn't recognize it was a bus. I think when I saw the thing coming, I think I closed my eyes and stepped on the gas."
The National Transportation Safety Board was called in to investigate. Board member Kitty Higgins said findings of the investigation will be released within a year.
Investigators said there were no skid marks, and they hoped to tap into the bus' computer system for clues. The driver had boarded the bus with his wife less than an hour before the wreck, relieving another driving team, authorities said.
The driver and his wife were at a hotel for about eight hours before taking the wheel of the bus, but investigators did not know how much of that time was spent resting.
The driver and his wife were wearing seat belts, Higgins said, but it was not known if any of the passengers were. Motorcoaches like the one involved typically do not have seat belts in the passenger section. Calls to the charter company, Executive Coach Luxury Travel Inc. of Ottawa, Ohio, were not immediately returned.
A statement headlined "We Grieve" on the company's Web site said in red letters: "We at Executive Coach Luxury Travel Inc. are deeply saddened by this travesty. We are continuing to cooperate with the officials investigating the accident in Atlanta, Ga. Our thoughts and prayers are with all of the victims and their families."
The university identified the victims as sophomores David Betts and Tyler Williams; freshmen Scott Harmon and Cody Holp; bus driver Jerome Niemeyer; and his wife, Jean Niemeyer, all of them from Ohio.
"This is deeply impacting all of our students, faculty and staff. We know these people on a first-name basis," said James Harder, the school's president. "For now we're pulling together and supporting each other as best we can."
The baseball team had been scheduled to play its first spring-training game of the season in Sarasota, Fla., on Saturday and had eight more games scheduled in Fort Myers, Fla.
The university is affiliated with the Mennonite Church USA. About one-fifth of the students are Mennonite, and the school stresses spirituality, but it is open to all religious backgrounds.
The church emphasizes pacifism and nonviolence. But unlike adherents of more conservative Mennonite denominations and the Amish, members wear modern clothing and use electricity. Smoking and drinking are banned on campus.
At a campus chapel service the night before the bus trip, students had prayed for safe travel for their sports teams and other students during spring break.
"Sometimes you take that stuff for granted," said Katie Barrington, a junior from Brooklyn Heights, Ohio.
Bluffton football players were working out in the weight room when they saw news of the crash on TV and recognized the logo on the bus as the company that all the school's sports teams have used, assistant football coach Steve Rogers said.
"That's when reality hit everybody," he said. "Everybody was in shock. Nobody knew what to say or what to feel." He added: "It hits home harder than it would if it had happened at a bigger school. Everybody knows each other."
Matt Ferguson, a freshman baseball player from Pleasant Hill, Ohio, said most of the freshmen had stayed behind.
"We were bummed out we didn't get to go," he said. "Now, we don't know what to think."
Associated Press writer John Seewer at Bluffton University contributed to this report.
On the Net:


text:
MichelleMac needed a new banner ad design and created a contest on 99designs.
A winner was selected from 151 designs submitted by 42 freelance designers.
Crowd Mountain
New product launch coming, and we need a banner to go with it!
This banner will go on a blog giving away free information and tools to promote our Crowd Mountain product.
Crowd Mountain provides tools and training in search engine optimization, niche marketing and social media optimization.
So,our target market is people who'd like to learn how to earn a living online in the internet marketing arena.
I've attached a screenshot of the blog theme we will be using.
The current Crowd Mountain logo is inserted, the banner you create should fill the whole space.
You should incorporate the existing logo into the banner. I've also attached the existing logo file.
It should be no bigger then 920px wide and 100px tall.
We're looking for something bold and exciting, with depth, that people remember. Nothing too dull and businesslike.
Winner must provide .psd files.


text:
Star Wars Stormtrooper iPad cover
Ralph McQuarrie was one of the most talented artists of our modern era. His work on the original Star Wars trilogy also made him one of the most famous. Ask people what they remember most about any of the original movies and something from the imagination of Ralph McQuarrie will likely come to mind. Darth Vader's helmet and mask, the beautiful Cloud City, or the chicken-like strut of the Scout Walker, all come from the mind of McQuarrie.
As big fans of his work, we were only too pleased to review the Stormtrooper iPad cover from Zeon. It's a simple soft silicon cover that provides bump protection for the iPad as well as bringing one of McQuarrie's most memorable designs to the iPad.
It's a solid cover that will appeal to Star Wars fans. Like many of these rubber covers, the bottom edge, by the home button, is a little on the feeble side, but it's generally a quality cover that will likely last the lifetime of your iPad. The official branding of the case and packaging makes it a superb gift option. It's designed for the iPad 2 and 3 only.
The Stormtrooper iPad cover is available from Mobile Fun at £19.95.
It's worth noting that Mobile Fun carries a large selection of iPad cases, covers and sleeves.
Further Reading: See all our accessories posts
References (5)
Response: familial mobile plans
Response: 350z headeriPad Creative - iPad Creative - Star Wars Stormtrooper iPad cover
Response: new year 2016rghbfg
Response: RenacenBut modernization has had a toll on various aspects, and which includes the cycling space in the cities.
Response: Боб Марли NoBob Marley


text:
CHICAGO – Two of the NBA's most dynamic point guards met up at United Center Friday evening and shared a few words about their mutual plights. Then they headed to opposite ends of the hallway, each to his individual routine, each according to his own timetable.
Ricky Rubio and Derrick Rose are brothers in rehab from knee ligament surgery. For the dazzling point guards of the Minnesota Timberwolves and the Chicago Bulls, the end of the 2011-12 season came dramatically and prematurely – Rubio in early March on an otherwise innocent-looking collision with Kobe Bryant, Rose near the end of Game 1 of the playoffs against Philadelphia.
From there, it was left-knee surgery for both – Rose tore his anterior cruciate ligament, Rubio both his ACL and medial collateral ligament). Lost opportunities at the London Olympics – Rose with Team USA, Rubio with Spain's national squad. And now, still, months of work on the side, often accompanied by therapists, trainers and coaches yet, in terms of where they'd rather be, always so alone.
"It's tough," Rubio told reporters in the visitors' dressing room before Friday's Wolves-Bulls preseason game. "It's a tough injury. You are like six, eight, nine months without playing your favorite sport. Sometimes it's just playing basketball where you forget about everything and you just enjoy it. I just wish him a healthy recovery."
Rubio got hurt nearly two months before Rose, which presumably has him about two months further along in his rehab. Minnesota coach Rick Adelman said the point guard, who turns 22 Sunday, has been limited to "straight-away" running and is about two weeks away from lateral cuts. He recently added a little jump to the set shots he had been taking.
Rose has been jumping for at least two weeks, but he still is projected to return after the All-Star break in late February or in March. Rubio's target date is sometime in December or possibly January.
"Every recovery is different," he said.
Losing Rubio for the start of this season was bad enough, but the Wolves' optimism for 2012-13 was dealt another blow Wednesday when All-Star forward Kevin Love suffered two broken bones in his right hand. Love, too, could be out until December if the 6-to-8-week prognosis goes full term.
Rubio said he had the same thought a lot of Minnesota fans had when he learned of Love's injury. "We have so much bad luck on this team," he said, sighing. " I don't know how to say, [if] it's too much for us. Because he's so important to this team. But it is what it is, we can do nothing. We just have to work harder and try to come back together."
Asked about Love's reaction when they spoke – the power forward traveled to see a hand specialist in New York and hasn't met with Minnesota media – Rubio said: "He's sad. He's mad. But there's nothing he can do except move forward."
That's how the Wolves have approached Rubio's absence, too. Adelman said he expects the point guard will have some rust and other challenges once he actually is playing again, but he was encouraged that Rubio had not let his spirits plummet over the injury and layoff.
"He was very surprising," Adelman said. "I really felt, as a young guy, he's so energetic in his approach to the game … but he didn't get down at all. He was disappointed, but I didn't really see him look like the world came to an end.
'"His whole thing has been, 'I'm gonna come back.' I think he's been that way since Day 1. That's a good attitude to have. He's young enough that, when he gets back, he should be fine. He's a great kid. He's a tough competitor. If anybody's gonna get there, it's going to be him."


text:
More and more hospitals require project competence, workflow experience and solutions from a single source. Maquet has many years of experience in the handling of large-scale hospital projects. We accompany the customer from the start of the project through to the final handover. As a result, customers are able to rely on comprehensive services at a high level, ranging from the design, planning, production and installation through to start up of operation. Maquet offers process-oriented solutions that guarantee to optimize resources and help to deliver best medical care.
With Maquet Hospital Solutions, a customized configuration is designed to meet each facility's unique needs and requirements. Each customer is assigned to a personal project manager; these project managers advise throughout the project, coordinating the involved specialists during all stages of planning and implementation.
A professional team ensures smooth procedures within all phases of the project. This centralized oversight ensures that each project can be implemented quickly and reliably in the specified time frame and within the specified costs.


text:
Follow RFF News on your cell phone. Text follow rff to 40404 you will receive txt messages with RFF News
0 Members and 1 Guest are viewing this topic.
PLEASE GET FIRST JASON & AMY (although the editing doesn't seem so good for them right now).
Page created in 0.092 seconds with 33 queries.


text:
Car hire spain, carjet., spain car hire, car rental, Car hire spain. a warm welcome to the homepage of carjet.com – since 1998, we've been searching out and serving up great car hire deals in the sunshine of spain, car.
Miniusa., All 2015 mini passenger cars come standard with boot to bonnet no cost maintenance standard for 3 years or 36,000 miles, whichever comes first..
Internetautoguide. – car buying guide – cars, Looking for the best price on a new or used car? research new cars and find used cars for sale. get the facts from the auto pros at internetautoguide.com..
Behavior modification – wikipedia, free encyclopedia, Behavior modification traditional term empirically demonstrated behavior change techniques increase decrease frequency behaviors.
Dpccars – fast sports cars videos | pictures, Largest collection videos fast sports cars street racing, car reviews, funny car videos, street racing pictures. added motorcycle videos, rc car.
Onlinecarinsurancequoteslgd. – $$$ free online car, Get car insurance quotes providers! home free quotes. insured? : .


text: On Fri, 2002-08-16 at 06:56, Yudong Tian wrote: > I am seeing something similar. If I use "ssh ipaddr" > or "ssh hostname.domain", the connection establishes > quickly. But if I use "ssh hostname", it will take > about 1 minute to get through. My DNS server and hosts > files are fine. "ssh -v" shows it gets stuck at "ssh_connect". Hmmmm. What's your /etc/resolv.conf file say? And what does "nslookup host" return? Finally, how long did that last bit take when compared to "nslookup host.domain"? This may not have anything to do with ssh. Cheers! --j -- Jim Meyer, Geek At Large purp at wildbrain.com


text:
Long Beach State's NCAA hopes were burst when it dropped its Big West semifinal contest to UC Irvine Friday night. But the 49ers still have games to play.
The 49ers (19-13) earned an automatic bid to the NIT for winning the conference regular-season title, and will open the invitational tourney Wednesday against Baylor (18-12) in Waco, Texas. The game is at 6 p.m. on ESPN2.
Long Beach is 2-2 lifetime against the Bears, but the teams have not met since 1979. A 49ers win would put them into a second-round game against the winner of the matchup between Arizona State (21-12) and Detroit (20-12).
It would also be the 49ers' first postseason win since 1990, when they beat ASU in the first round of the NIT, 86-71.
"This gives us a second chance," 49ers coach Dan Monson said in a statement after the brackets were announced. "Everyone in the NIT had dreams of playing in the NCAA Tournament, but just weren't consistent enough to get in, so this gives us a second chance.
"Baylor is a solid team, with one of the top big men in the country in Isaiah Austin. We know they have good players and are a national-caliber program. It's going to be a tough game, but as competitors, our guys have to step up and focus on this opportunity to go out and continue our season. Hopefully our team will have that mindset on Wednesday."
The 32-team field includes Stephen F. Austin, which beat the 49ers in a BracketBuster game at the Pyramid last month. The Lumberjacks (27-4) have the best record of any team in the NIT. Louisiana Tech (26-6) of the Western Athletic Conference also wound up in the NIT.
Besides ASU, two other Pac-12 teams are in the field, Stanford (18-14) and Washington (18-15), as is West Coast Conference third-place team BYU (21-11) and defending national champion Kentucky (21-11).
The 49ers lost a first-round NIT match to Washington State in 2011; to Cal in the first round in 2000; and TCU in the first round in 1993.


text:
Arden Flounce Bikini Set
Lisa Marie Fernandez
Lisa Marie Fernandez
Or 4 installments of $48.50 by afterpay Learn more about Afterpay
- 72% nylon , 28% elastane
- Hand wash cold
- Back buckle closure
- Stretch fit
- Ruffled detail
- 2 piece set
- Revolve Style No. LAMX-WX39
- Manufacturer Style No. CORE084 WPB
- Modeled in size 2.
- Model Measurements: Height 5'9", Waist 24", Bust 32", Hips 34"
- Size Guide
Since introducing her sleek neoprene swimwear in 2009, the American-born fashion editor turned designer, Lisa Marie Fernandez, has developed her collection into a coveted swimwear brand. Directional, luxurious, and functional, Lisa Maries distinctive designs reflect her own lifestyle, one inspired by her travels around the world and the women that influence her. Referencing the minimalist scuba styles of the 1990s, Lisa Maries curve flattering silhouettes sport her signature color blocking, exposed zippers and geometric seams that have attracted the attention of fashion editors and models alike.
If an item you would like to purchase is out of stock, you can place a Special Order Inquiry. REVOLVE will then check the availability and obtain an approximate arrival date for the item, if available. Typically, it takes up to 3-4 weeks to verify this information.
Placing a Special Order Inquiry is absolutely free and there is no obligation to follow through with a purchase.
- You will be notified by email once we receive the item.
- You may cancel at any time without penalty
- Your card will ONLY be charged when your order is shipped.
- Availability is not guaranteed.


text:
Hating on Yombe
November 11, 2011 2 Comments
I have a disturbing love/hate thing going on with Yombe maternity figures, and to a lesser extent Songye fetish figures. This probably started in 2010 when I photographed a "phemba" at the Brooklyn Museum, and in a flash I was hooked.
Tribal African Art doesn't get more beautiful than these pieces, and collecting really has it's own rewards. I guess at first glance it might be hard to relate to the filed teeth and all, but there is a deep spirituality associated with the concepts of birth and death that is uniquely handled by the Yombe!
Yombe maternity groups, called phemba, were used in association with women's cults. While little is known about the meaning of different phemba iconographies, two main variants can be identified: a cross-legged woman with a "lifeless" infant on her lap and a cross-legged, kneeling or crouching woman with a living infant.[1]
The phemba shown above was in the collection of Robert Rubin (acquired in 1984), and sold at a Sotheby's auction (05/11), in NY for $US1.87 mil.
The frustration of trying to find one (read as cheap), pretty much covers the "hate" side of the equation. Maybe it was the Red Bull, followed by a cappuccino mix, but at auction time week ending 11/11/11, I was pretty much as primed to shed some cheese as Imelda Marcos in a Louboutin sale. The phemba which I could not afford, but which I purchased anyway is shown below.
One of the fascinating aspects of the sculpture is the facial expression, and the impression of restraint, and strength, shown alongside the gentle cradling of the infant's head. These figures possibly are connected with mpemba, a women's cult said to have been founded by a famous midwife (circa 1770), and concerned with fertility and the treatment of infertility. They are popular among the Kongo peoples of western DRC (formerly Zaire), especially among the Yombe.
The figure shown, illustrates a person of high rank in society, as testified by her cross-legged pose on a pedestal and her many body adornments. The chiseled teeth, the corded-firm breasts, the close fitting "mpu" hat, and especially the raised scarification marks indicate ideals of beauty and perfection. The double bracelets around her upper arms imitate protective charms called "nsunga"; made of plaited or braided raffia fibers, they are worn by religious experts and by ill people as a cure.[2]
Meant to stimulate sexual pleasure, the scars were considered both beautiful and erotic, but they show the strength, nature, and character of the women as well.
During their ritual use, the surfaces of the figures were rubbed with a reddish mixture of oil and camwood powder, both a cosmetic and a sign of mediation. In Yombe thought the color red indicates transitional conditions such as death and birth. The fact that some mother-and-child figures hold or carry what appears to be a dead baby alludes to the close interrelationship in Kongo beliefs between the spirit world and the world of the living.[3]
Another perspective is as follows,
Mother and child figure represents the female ancestor taking care of her descendants.This commemorative figure would have been used to honor the maternal spirit who brings prosperity and fertility. Among the Kongo people, the woman is considered as the chief of the family. Thus, the female ancestor is the guarantor of the fecundity and continuity of the clan or family. Such sculptures would be kept on a family or local shrine where she would be receive sacrifices and offerings.[4]
[3] http://www.randafricanart.com/Yombe_maternity_figure.html


text:
Perimeter Dog Fence Containment System Basic Ultra Comfort
Model: PCC-200
Wire included: 500' 20 Gauge
Lightning Protector: No
Perimeter Dog Fence Containment System Deluxe Ultra Comfort Contact 20 Gauge
Model: PTPCC-200D
Wire included: 500' 20 Gauge and 100' Pre-Twisted 20 Gauge
Lightning Protector: Yes
Perimeter Dog Fence Containment System Deluxe Ultra Comfort Contact Plus 18 Gauge
Model: PTPCC-200DP
Wire included: 500' 18 Gauge and 100' Pre-Twisted 18 Gauge
Lightning Protector: Yes
Most Humane Contact Points: Comfort Contacts™ by Perimeter® offer the most comfortable solution to create contact with your dog. Conductive metal infused rubber provides significant protection against pressure necrosis, a condition which occurs when a dog either has a negative skin reaction to metal touching their skin or the collar is left on for a prolonged period of time. Soft conductive rubber contacts allow the contact to remain constant keeping your dog safe at home with utmost is comfort.
Dog Crates, Dog Beds, Dog Exercise Pens, Dog Carriers, Dog Feeders & Bowls
Dog Crate Pans, Dog Crate Covers, Dog Kennels, Pet Barriers


text:
On a recent visit to Tra Vinh, I saw an unususual sight: next to the sea dike, which was built to prevent sea water intrusion, a farmer was pumping sea water back over the dike onto his rice fields. What was happening?
From 1998, the World Bank lent the government $68,000,000 to build the South Mang Thit sea dike and draining system in Tra Vinh Province. It was designed to stop sea water intrusion and thereby ensure the continued production of rice (and to a lesser extent fruits and vegetables). But 10 yers later, farmers behind the dike are still short of freshwater and rice productivity is very low and unstable. Because of their low incomes, farmers are increasingly interested in shrimp farming. And to farm shrimp they need sea water.
In the two villages I visited in My Long Nam Commune, although two sluice gates were open, more sea water was needed. So the government has built a third sluice gate at a cost of $750,000 to provide water to 190 hectares of shrimp ponds. "Farmers want to turn their rice field into shrimp ponds and they do so. The gorverment then has to support a new sluice gate to open up water flow for this area", said an official from the Tra Vinh Department of Agriculture and Rural Development.
But even this third sluice gate doesn't provide enough sea water and so in some areas farmers are operating their own pumps. Hence, the strange sight of the famer pumping sea water back over the dike, a reaction that calls into question the value of bulding expensive dikes to maintain production of low value rice when shrimp farming is a more attractive economic option. Of course, shrimp farming has its own environmental problems, but combined with mangroves, crabs, and fish, it can provide a diverse livelihood that is resilient to sea level rise and an increasingly salter environment . This experience indicates that central government should invest is supporting, not inadvertently preventing, this transition.
Ms. Nguyen Ngoc Anh - Project Manager - DANIDA funded MFF in Ben Tre and Tra Vinh Province


text:
Physician Assistant
Technical Standards
All candidates and students for the Physician Assistant (P.A.) Program must possess certain capabilities and skills, with or without reasonable accommodation. These include the intellectual ability to learn, integrate, analyze, and synthesize data. They must have functional use, with or without accommodation, of the senses of vision, hearing, and equilibrium. Their exteroceptive (touch, pain, temperature) and proprioceptive (position, pressure, movement, stereognosis, and vibratory) senses must be sufficiently intact to enable them to carry out all activities required for a complete P.A. education. Candidates must have motor function capabilities to meet the demands of P.A. education and the demands of total patient care. The candidate for the PA Program must possess the following capabilities and skills:
1. Observation: The ability to observe is required for demonstrations, visual presentations in lectures and laboratories, laboratory evidence and microbiological cultures, microscopic studies of microorganisms and tissue in normal and pathologic states. Candidates and students must be able to observe patients accurately and completely, both at a distance and closely. This ability requires functional vision and somatic sensation and is enhanced by a sense of smell.
2. Communications: Candidates and students should be able to communicate intelligibly, and to observe patients closely in order to elicit and transmit information, describe changes in mood, activity, and posture, and perceive non-verbal communications. The candidate must be able to communicate effectively and sensitively with patients. Communication in oral and written form with the health care team must be effective and efficient.
3. Motor: Candidates and students should have sufficient motor function to elicit information from patients by palpation, auscultation (with or without accommodation) and percussion, as well as carry out diagnostic maneuvers. A candidate should have motor function sufficient to execute movements reasonably required to provide general care and emergency treatment to patients. Such skills require coordination of gross and fine muscular movements, equilibrium, and sensation.
4. Intellectual - Conceptual, Integrative, and Quantitative Abilities: Problem solving is a critical skill demanded of P.A. s and this requires all these abilities. Candidates and students must also be able to comprehend three-dimensional relationships and the spatial relationships of structures.
5. Behavioral and Social Attributes: Candidates and students must have the emotional health to fully use his/her intellectual ability, exercise good judgment, complete all responsibilities attendant to the diagnosis and care of patients.
The practice of medicine requires physician assistant candidates and students be able to develop mature, sensitive, and effective relationships with patients and colleagues. To provide high quality patient care, physician assistant candidates and students must possess characteristics of adaptability, flexibility, and be able to function in the face of uncertainty. The healthcare environment requires candidates and students be able to tolerate physical and emotional stress and continue to function effectively and efficiently. He/she must have a high level of compassion for others, motivation to serve, integrity, and a consciousness of social values. Candidates and students must possess sufficient interpersonal skills to interact positively with people from all levels of society, all ethnic backgrounds, and all belief systems.
Candidates for admission to the PA Program are encouraged to ask questions about the program's technical standards for clarification and to determine whether they can meet the requirements with or without reasonable accommodation. Any information and inquiries about disabilities are handled in a confidential manner, to the extent possible within the accommodation process, and should be directed to the PA Program Director.
The Physician Assistant Program faculty recognizes the responsibility to present candidates and students for the P.A. degree that have the knowledge and skills to function in a broad variety of clinical situations and to render a wide spectrum of high quality patient care. The responsibility for these technical standards is primarily placed on the P.A. Program Interview Committee to select entering P.A. students who will be the candidates for the P.A. degree.


text:
Stevens Pass cares about our relationship with the community, especially since the vast majority of our staff live off-mountain in the surrounding towns. We support a wide range of non-profit and educational causes that seek to expose people to the alpine environment and its conservation.
Nature Education – Inside the ski school building, a very popular natural history mural helps us explain the ecology of our alpine setting to many of our younger skiers.
Nordic Center Adopt-a-Highway – For over a decade, Stevens Pass Nordic Center has adopted its own section of U.S. Hwy 2, keeping it clean of litter using volunteer work days; much of the litter is recycled (aluminum cans and plastic bottles).
Summer Parking Cleanups – Every Thursday, all summer long, all staff spend two hours collecting litter and recycling from the slopes, and especially the parking lots, in order to restore the beauty and health of our mountain environment.
National Forest Foundation – We partner with this non-profit foundation to operate annual volunteer slope clean-up days. We also offer all guests an option to donate $2 to the Ski Conservation Fund, which NFF matches at 50% and applies towards conservation projects on the federal lands where we operate. Learn more on our "How You Can Help" page.
Environmental Education Programs – Stevens Pass helps support day-long winter environmental education programs for youth groups, conducted on-site by the U.S. Forest Service. Part of the trip includes a rescue demonstration by a Stevens Pass Pro Patrol avalanche dog handler, who will also explain the safety hazards of the winter mountain environment. These midweek-only trips are ideal for schools, outdoor clubs, or other extra-curricular groups during school breaks. Call Skykomish Ranger District for more information at 360-677-2414.
Snowshoe Trek with a Ranger – Learn about Stevens Pass winter ecology and the outdoors from a U.S. Forest Service interpretive ranger, offered weekends only, on-mountain January through February each winter. Sign up directly with the Skykomish Ranger District.
"Sustainable Slopes" Environmental Charter for Ski Areas – The National Ski Areas Association (NSAA), together with its member ski areas and partnering organizations, has created an environmental charter: a set of voluntary environmental principles to aid in ski area planning, operations and outreach. The Charter affirms the commitment ski areas have in improving environmental performance in all aspects of operations and managing their specific resorts, making possible their continued enjoyment by future generations. Pacific Northwest ski areas have provided recreation to millions of guests each year on a very small portion of public land; this very efficient and closely managed utilization of resources limits total impact on mountain ecosystems.
Sustainability Locally / Earth Day – Leavenworth, WA is our nearest large town and serves as the eastside gateway to Stevens Pass Mountain Resort and the Central Cascade Mountains. Local community members and business owners have launched a citizens' process to discuss how to harness sustainability as a tool for community and business development in Leavenworth, and also how to promote the significant low-impact recreation potential the region. Stevens Pass is proud to be a member of this initiative, attending committee meetings and sponsoring the popular annual Earth Day Fair since it began in 2009.
Outdoor Recreation for Disabled Populations – Since 2004, we have partnered with Outdoors for All, a Seattle-based non-profit providing year round instruction in outdoor recreation for people with physical, developmental, and sensory disabilities. Participants enjoy cross-country skiing, snowshoeing, and alpine skiing at Stevens Pass facilities at reduced rates, often as part of multi-week camps, and we are proud to support this work.
Leavenworth Winter Sports Club – In February 2012, Stevens Pass and entire ski community suffered a tremendous loss when a huge avalanche just outside our boundary swept away three highly influential local skiers, including our very own Marketing Director Chris Rudolph. Although numerous commemorative events have occurred in the time since then, the community settled on a permanent memorial at the local ski hill, where most kids first try out the sport and learn to love the outdoors. Stevens Pass has donated approx $40,000 so far to the project (Leavenworth Ski Hill Heritage Foundation), which will help fund a more functional and sustainable facility where young skiers will learn how to enjoy winter and also get involved in protecting its future.
Tulalip Tribe Interpretive Exhibit – In autumn 2012, we completed a large outdoor interpretive installation located in our entry plaza explaining the history of Native American presence and their sustainable practices, long before the ski area arrived 75 years ago. In an agreement with the Tulalip Tribes, the panels were installed at our cost of $20,000; they document a simpler, seasonally-driven lifestyle, and advocate for continued efforts to properly steward the mountain landscape as partners.
Other Support
We are also partnered with the Service Board, a non-profit group based in Seattle that uses mentors, community service and snowboarding to change the lives of disadvantaged youth in the metro area. Stevens Pass provides all participants in the program free rentals and free lift tickets.
We support other progressive community efforts such as the SHARE Community Land Trust which helps provide affordable housing for low-income residents around Leavenworth, WA. Stevens Pass has committed $10,000 over 5 years.
Frequently throughout the year we also provide support to a number of non-profit organizations in the form of donated lift tickets for fundraiser events; recipients include groups such as the Friends of the NW Avalanche Center, the Environmental Education Association of Washington, The Homewaters Project, etc.


text:
I was hacked last week ,and now i have recently re-imaged my server but i still have a folder/script trying to brute force another server via my own server. so as you can see this was due to a installed website backup.
My problem is i dont have a clue how to trace the source of the attack. I have installed splunk succesfully to try and make my life easier but i dont know were to start to search and query.
For your information the server that my server is trying to hack is 18.104.22.168.[port]: SIP if this helps
my operating sys is centos 5.5 and i have plesk 9.5 running on my server.
help is needed as soon as possable as my hosting company have given me until tomorrow to sort it or they will block and shut my server.
thanks in advance


text:
The Flipped Classroom: How to Prepare and Teach a Flipped Classroom
- Date: May 30, 2017 - 15:00 - 16:00 (local time)
- Presenter: Chris Harrison
- Categories: Electrophoresis / Detectors / Laboratory Informatics / Sample Preparation / Gas Chromatography / Ion Chromatography / Proteomics & Genomics / HPLC / Base Peak / Chemometrics & Informatics / Atomic / Infrared Spectroscopy / X-ray Spectrometry / Proteomics / UV/Vis Spectroscopy / NMR Knowledge Base / Raman
The Flipped Classroom – How to Prepare and Teach a Flipped Classroom
Broadcast on May 30, 2017
This webinar is now available on-demand.
If you have already registered for this event, please login
using the link provided in your registration confirmation email.
Register now >>>
This webinar will present the concept and rationale for using a flipped classroom to teach analytical chemistry at university level. Along with presenting methods for how to create the flipped classroom, strategies on how to conduct the class time, and engage the students will be discussed.
What will I learn?
- Various techniques for preparing a recorded lecture
- Considerations for what needs to be included in a recorded lecture
- How to prepare students to succeed in a flipped classroom
- Strategies for fostering active learning in the physical class time
Who should attend?
- New faculty/instructors
- Experienced faculty/instructors
- Graduate students and postdocs interested in teaching
Your Presenter
Christopher Harrison
Associate Professor of Chemistry
San Diego State University
California, USA
Christopher Harrison: Biography
Christopher Harrison is an Associate Professor of Chemistry at San Diego State University. Along with his research program focusing on the application and understanding of capillary electrophoretic separations, Professor Harrison has been at the forefront of advancing the teaching of analytical chemistry. He has written several articles on his incorporation of digital technologies into his chemistry classrooms, and spoken at numerous conferences about his teaching philosophies and approaches. He is an active contributor to, and editor of, the Analytical Sciences Digital Library, and has shared his flipped analytical chemistry lectures through Chromedia.


text:
The monstrous 60" Jelliquarium TANK ONLY is an all new, exciting home or office jellyfish display system intended to be built into a wall or cabinet.
This Jelliquarium TANK ONLY is 60" Long by 16 Wide and 60" Tall. The tanks unique 170 gallon faceted tank design includes true surface skimming and an anti-siphon design feature. This tank come standard with a clear back ( colored back optional ) for two-sided viewing. A laminated colored back is available in Black, Light or Dark Blue
Optional lighting consists of an ABS light hood and two 40 watt light fixtures, a blue Actinic and a 20,000K fluorescent bulb.