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The ToolsNow mini lathe is a 7×12 mini lathe. The ToolsNow mini lathe had more accessories than any of the others, including a faceplate, a steady rest, a …
Mini Lathe Comparison
This amazing mini lathe produces precision work without taking up a lot of room in your shop or garage. For turning and counter facing, as well as making bushings, spindles, prototypes, models and more, this precision mini lathe runs at two speeds: Low runs 0 to 1100 RPM and high runs 0 to 2500 RPM.
7" x 12" Mini Metal LatheHarbor Freight Tools
The mini lathe is made by several manufacturers in China. There are several different models including a 7×10 model, a 7×12 model, a 7×14 model, and a 7×16 model. The 7×12 model is actually 4 inches longer than the 7×10 model, and the 7×14 and 7×16 models are …
Mini Lathe
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The G8688 7″ x 12″ Mini Metal Lathe was a good purchase for me. I'm new to metal working and have already broken a couple cutting tools and blown a fuse, but the machine was straight forward to setup and learn so I'm routinely producing parts with about 1 to 2 mil accuracy and expect to improve.
7" x 12" Mini Metal Lathe | Grizzly Industrial
A 6 speed mini lathe is designed for small to medium sized projects. Use the lower speed for rough shaping and the higher speeds for more precise finishing. For larger projects, a powerful bench lathe is built for long-lasting durability and maximum performance.
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Bolton Tool's metal lathes are built to last and maintain the accuracy you need from a well built machine. We offer several models including mini lathes, gunsmithing lathes, variable speed lathes, toolroom lathes, combo lathe/mill all giving you the precision you require.
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This Klutch® Mini Metal Lathe delivers big performance. The compact 7in. x 12in. lathe features a 7in. swing-over bed and quick locking tailstock. Has a dependable 3/4 HP, 110V motor.
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Metal Lathes
This Precision Benchtop Mini Lathe delivers exceptional performance on small parts and prototypes. The mini lathe has variable speed control for a wide variety of materials and a chuck guard for safety.
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The MicroLux ® 7 x 16 Mini Lathe is so versatile it will cut all metals, including carbon steel, stainless steel, cast iron, aluminum, brass, copper, bronze, and nickel-silver, plus non-metals such as wood and plastic. And, with the optional accessories sold separately, it will …
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This mini lathe machine can be used to work with wood, plastic, soft metals (aluminium, copper, etc.), softwood and hardwood. It features a three-jaw chuck or collet …
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The lathe is the standard metalworking machine used to produce rotationally symmetric metal workpiece though precise cutting production processes. There is a wide range of rotational components that can be produced on a lathe machine , including components from simple cylindrical shafts, circular and spherical formed components, to complex .
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"We've used Mequoda's strategies and techniques to sell thousands of books, videos, and subscriptions."
- Charlie Spahr, Executive Director, The American Ceramic Society
Programmatic advertising is growing in the digital marketing world, and that world coincides closely with the digital publishing industry. Do you know what programmatic advertising is or how it can impact your business?
How to generate more revenue as a target-interest magazine publisher
Our friend Carl Landau run the Niche Digital Conference. The conference is about generating more online and mobile revenue for niche magazines. Carl shared with us a list of 15 digital revenue ideas for target-interest magazine publishers from last year's conference:
1. Create new content for your website,
Catch up on the Mequoda Daily's blog posts for this past week
Insight taken from Dan Ambrose, online advertising expert
New types of online advertisements are intriguing. They are a bit different than traditional advertisements and are welcomed by consumers.
Regardless of the acceptance of new online advertisements, it's important to keep other parts of online advertising in mind as well, since it's not just about creating media-rich advertisements that viewers will enjoy. Online advertising also includes capturing new revenue streams, selling integrated programs, designing factors for accommodating online advertisements and successful sales strategies, among others.
The main point of online advertisements is to gain conversions.
Landing pages need prominent conversion architecture to successful convert casual visitors into email subscribers.
Successful conversion architecture is clearly labeled, above the fold and simplistic in nature. Whether the website is selling a product or offering a free signup for an email newsletter or a complimentary download, the positioning and language of the landing page's conversion architecture needs to be the main focus.
Catch up on the Mequoda Daily's blog posts for this past week
From Facebook to PPC, all online advertisements have some elements in common
Online advertisements have some traits in common. Although the content will always change and be dependent upon industry expectations, there are some elements that should always exist in popular ads.
A recent article on Search Engine Watch points out the five elements used in ad copy. Their article particularly focuses on ad copy for PPC campaigns, although the same rules apply for any type of ad copy you are creating. Let's take a look at these elements now:
Catch up on the Mequoda Daily's blog posts for this past week
Advertisers will spend more on Internet ads than on print newspapers by the end of 2010
We are upon a historic note.
Online advertising will grow 13.9% to $25.8 billion for the entire year of 2010. When it comes to print, advertisers are expected to spend $22.78 for the year of 2010. This statistic is down 8.2% from 2009.
This is the first time ever that online advertising will top print advertising for an entire year.
Getting viewers to click on your text ads is easier when you follow these tips
Online advertisements are a topic of discussion these days, not just because of their effectiveness, but also because of changes that are taking place within its industry.
For starters, did you notice that Google recent changed its "Sponsored Links" section of its website to simply "Ads"? This alone has stirred the pot of curiosity and has pundits and bloggers speculating reasons as to why this move was made.
A different way to look at contextual ads
I recently attended a seminar in Philadelphia called the AdWords Seminars for Success. The presenter was Brad Geddes, the founder of bg Theory and a long time Internet marketing veteran.
The seminar discussed many aspects of Google AdWords, from writing text ads to testing different variations.
An interesting concept I was exposed to during both days was that "Advertising isn't advertising when it's information."
Catch up on the Mequoda Daily's blog posts for this past week
A few tips to sell more online advertisements with strong website design
Website design isn't just important to the users that visit your website, it is also important to the advertising that you want to engage in with your website.
Every online publisher wants to have a highly efficient and effective website. Having this type of website will encourage return visits and generate revenue through direct product sales as well as online advertising.
When it comes to offering online advertising on your website, are you capable of doing so? Is your website designed properly so that online advertisers will want to work with you?
WritersMarket.com is a Pay-For-Access, Online Database of Incalculable Value to Freelance Writers that Cross-Sells Print Publications and other Products Owned by its Publisher as it Helps Build a Priceless Customer List
Online databases sold by subscription are big business for LexisNexis, R.R. Bowker, Thomson and other traditional publishers of directories.
The idea makes a lot of sense. An online directory is easier to update and keep current, and the costs for manufacturing and delivery are minuscule compared to those of a printed volume. Major directory publishers generally offer both print and online versions and these can be very pricey.


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$2,000 – Quakertown, PA:
"1995 BMW 318ti- we've had this car for a few years and put about 50k miles on it.
Bad stuff:
-The interior is less than perfect, still functional but the seats have seen better days
-A/C and sunroof don't work
-There is a some rust starting around the wheel wells and jacking points, and a repaired spot in the driver's footwell
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-Comes with 16″ Kosei K1 wheels shown in photos as well as the stock 15" wheels with snow tires (which are currently installed)
-Car was repainted the factory green a few years ago and still looks pretty good
The car will include all stock parts that were removed when we made the suspension upgrades.
Car or motorcycle trades considered, mountain bikes plus cash may also be an option.
This car is solid but a little bit scruffy, please contact me with any questions.
1995 BMW 318ti
condition: fair
cylinders: 4 cylinders
drive: rwd
fuel: gas
odometer: 187000
paint color: green
size: compact
title status: clean
transmission: manual
type: hatchback "
Source: https://allentown.craigslist.org/cto/6810752713.html
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LEYTON FC have quit non-league football, ending 143 years in the game.
The plug was pulled on London's oldest club by director Louise Sophocleous.
She emailed a resignation letter last week to Ryman League chairman, Alan Turvey.
"If I regretted it, then I would not have done it," she told Guardian Series Sport.
"I thought long and hard about this and I have been talking with my family about it for a long time."
Dismay has greeted the news of Leyton FC's passing from senior non-league football.
A trophy final at Wembley and a pile of silverware won over decades is Leyton FC's grand heritage.
"No-one wants to see a club go out of business, especially not a club like Leyton," said chairman Turvey.
"This should sit very heavily on the minds of the people at the club."
But Sophocleous was defiant. She said she simply did not have the time for the club, calling it a "one-woman show."
"It's the time factor which was the thing for me. The club is all me and as important as it is, I've decided to do this.
"I am devastated that it came to this. I tried my hardest for the club, but it's been a one-woman show."
Non-payment of around £700 in subscriptions sparked the club's suspension from Ryman one north, last week.
Soon afterwards, Sophocleous' resignation email landed in Turvey's inbox.
But she said that the club does not owe money to the Ryman League.
But the cash dispute will now hamper future attempts to return Leyton to the non-league game.
The League is set to oppose any bid for as long as the debt is outstanding, Turvey has said.
Youth football is the future of Leyton FC not the senior game, said Sophocleous.
"I want to give my all to the youth side and football in the community," she said.
Sophocleous added money had nothing to do with her decision to withdraw from the League.
"Money has always been an issue, but it was not that which stopped us," she said.
The entire playing staff and boss Gordon Boateng quit last week, along with members of the board.
Chairman Tony Hardy resigned after 12 years at the club.
"Everyone did their best to keep the club going and going, but the funding was not there," he said.
"Day to day costs were unaffordable.
"The Christmas period was when we found out that we would not be able to keep it going. The weather had a big impact."
Sophocleous' decision marks the end of a century and a half of footballing tradition in east London.
Hardy lives around the corner from the Lilywhites' ground at the Lea Bridge Road stadium.
He branded the end of an era "a travesty."
"It's shocking," said Hardy. "It's not something I ever wanted to see happen."
Get the view of ex-boss Gordon Boateng, online at www.guardian-series.co.uk/sport.


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Posted / Updated on : 25-Oct-2018
KAUSHAL GODAVARI - VIKASA WON THE PRESTIGIOUS NATIONAL AWARD i.e.., SKOCH AWARD to KAUSHAL GODAVARI SKILL DEVELOPMENT AND EMPLOYMENT FACILITATION PROJECT and the same was presented at New Delhi for the services rended by this organisation for the benifit of unemployed youth.
The award was presented to Sri.J.Mallikarjuna Rao- Joint Collector, East Godavari on behalf of the District Collector along with Sri. V.N. Rao - Project Director, and L.Chandra Obul Reddy (PMRDF Consultant)


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"Children thrive when they're inspired, and given the tools, encouragement and guidance they need. Let's not fail them!"
The Foundation helps children by providing life-altering, inspirational speakers to help inspire and provide hope, guidance, pathways, and encouragement to children and adults, at no cost, to qualified schools, youth groups, and other non-profit organizations that could not otherwise afford it, where the children and adults need it most, especially in low socioeconomic and underprivileged areas. Our unique roster of world class speakers can focus on a wide range of topics and come from the worlds of action sports, science, music, art, education, self-help, business, politics, humanitarian work and more. – Browse though our amazing roster of speakers here >
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A) The type of non-profit organization you are, such as a registered 501(c)(3), NGO, youth group, or other types.
B) Your annual operating budget and review of your financial records to help us ensure we are prioritizing organizations that would otherwise not have the means to secure a speaker on their own.
C) The size of your organization and the number of people you are requesting a speaker to talk to.
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Za današnji post sam vam pripremila jedan outfit za malo toplije jesenje dane u zelenim i sivim tonovima. Nadam se da će vam se dopasti!
I think the highlight of this outfit would be this cute green blouse with white stripes. I've mentioned I wanted this blouse in my wishlist post which you can read HERE and after that, I've decided to order it from ZAFUL. In that post, I've mentioned it could be good for school days but now I've realized it's a lot shorter than I thought, it's really crop top and I'm not sure if I could wear it on high waisted jeans, because I wouldn't like for my whole outfit to be tight, I'd rather wear it with skirts like this one on the photo or some wide leg pants. The blouse is so cute and material is okay, mix of polyester and cotton, although I think polyester is in bigger percent. I've noticed that all shirts or blouses, which I got lately from sites like ZAFUL, are in this material, probably 65% polyester and 35% cotton. They feel silky when you touch them and they are really good when it comes to ironing because they don't get wrinkly that easily, which I really like! It's available in orange colour with white stipes and in white colour with black stripes, I've ordered it in size M and it fits me perfectly, it costs only $13.28 and it's on sale, half-priced currently so if you want it you can order it HERE .This gray skirt was, also, ordered from ZAFUL, more than a year ago and it's still very pretty, quality is great. Gray sandals are from Deichmann. These sandals became really popular this Summer, I bought them this Spring and I've noticed that a lot of girls wore them this Summer. I still really like them, although I don't really like to have clothes or shoes the same as everyone else and I am kind of "running away" from copying. That would be everything for this outfit post! It's really simple and yet, if you ask me, elegant outfit for going out or some special occasions. Thank you so much for visiting my blog and reading this post, I hope you've liked it! If you did, write me in the comments below do you wear skirts in Autumn season or it's too cold in your town for that? I love you all so much and talk to you really soon!
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34 komentari
Stunning! Gorgeous outfit.OdgovoriIzbriši
❀ ADRI IN PINK ❀ INSTAGRAM ❀Odgovori
Thank you so much!Izbriši
Amazing !
Sarah, http://www.sarahmodeee.fr
Nice outfit😊OdgovoriIzbriši
Košulja mi je baš slatka. :)OdgovoriIzbriši
Novi post http://andjelina-svastara.blogspot.com/2018/10/halloween-month.html :9
Que lindo esse look adorei.OdgovoriIzbriši
Jana Makes Esmaltes e Cia
wish you happy weekend!!OdgovoriIzbriši
Sony Pen drives online
Mnogo ti lepo stoji ova kombinacija boja. :)OdgovoriIzbriši
Outfit je fantastičan i nevjerovatno je koliko ti dobro stoji. Kombinacija boja je odlična. Divan post. :)OdgovoriIzbriši
Mnogo hvala draga!Izbriši
Ppreeesladak outfit! Ne znam sta mi se vise svidja!!!!OdgovoriIzbriši
- Anonimno6. listopada 2018. u 19:24
Super outfit!♡OdgovoriIzbriši
Outfit je presladak i prelijepo ti stoji. ;)OdgovoriIzbriši
Nestvarni svijet blogerke
Beautiful outfit, very stylish!OdgovoriIzbriši
Freak Muffin BlogOdgovori
Thank you very much!Izbriši
What a gorgeous and stylish look dear. Love those green blouse. We had such a beautiful Autumn weather too, at the moment, so much sunny Autumn.OdgovoriIzbriši
Love xo, Kintan
Thank you so much! Glad to hear that!Izbriši
I really love that shirt *.*OdgovoriIzbriši
Blog An Aesthetic Alien | Instagram | Facebook
Glad you like it, thank you!Izbriši
Odličan post. Outfit je presladak! :)OdgovoriIzbriši
Novi post: www.minniearts.com
You look so classy. xxOdgovoriIzbrišiOdgovori
Thank you very much!Izbriši
Amazing outfit, I like your blouse.OdgovoriIzbriši
Outfit mi je stvarno prelijep, a prokomentarisala sam to i na instagramuOdgovoriIzbriši
Delilah's Stories | Filmtastično


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Chapter 584 – Opening the Cage
"Ridiculous? Hahaha!" Maha laughed. "Letting you practice for so long in Skysplit Tower is already letting you take advantage of us. Now we are even letting you leave with your life intact, but you still have such much nonsense to babble on about. Do you still not understand anything? Here, strength is everything! You'd better be smart enough to know what to do, or else, if you want to do things the hard way… hehe…" Maha's words ended here with a sneer. The meaning behind this threat was very obvious. Of course, he didn't dare to speak this out publicly and instead used a true essence sound transmission.
"So you're saying that someone's going to come and deal with me? I wonder who you're going to send. The Heavenly Demon Seven Stars? A High Lord?" Lin Ming aggressively responded, simply unafraid of Maha.
If Lin Ming was really assassinated then that would truly be a troublesome matter. Lin Ming was simply too strong; killing him would make a giant mess of things. If a High Lord personally acted then that would be blatantly violating Skysplit Tower's rules. If that time came, then the rumor of 'all the strong people who go to Skysplit Tower will be killed' would spread like wildfire. If this happened, then who else would still dare come to Skysplit Tower?
Maha grimaced. "It seems that you're going to resist until the end. Fine, I will take one step back. If you leave Skysplit Tower then I'll give you a tael of low-grade Demon God Bone. This is my final offer."
"Demon God Bone?"
Lin Ming's mind stirred.
"Humph, you probably don't know how valuable something like that is. I can tell you without exaggeration that a Demon God Bone is enough to cause a Demon King level martial artist to go crazy! Using it to just temper the body is a waste. If one integrates it into their life source and nourishes the fires of their life, then it can even be of great help to someone trying to break through to be a Demon Emperor!"
The Demon God Bone was naturally promised by the High Lords. Maha hadn't wanted to give this to Lin Ming, but after seeing Lin Ming so stubborn and defiant, he could only reluctantly put out this condition.
"Integrate it into one's life source to nourish the fire of life. It can help a Demon King powerhouse break through the Demon Emperor bottleneck. It can be used to temper the body, but that is a waste… I see…"
Lin Ming learned a great deal from Maha's words. It was obvious that Maha didn't know Lin Ming had already obtained a Demon God Bone.
According to Lin Ming's knowledge from the own Demon God Bone he had, a tael worth of low-grade Demon God Bone was only the size of a cherry seed.
As for the one Lin Ming had, it was the size of a pigeon egg. This was the Demon God Bone that was granted to Xing Tian.
A mere Xing Tian with his status as the king of the second floor could obtain a Demon God Bone the size of a pigeon egg.
But his own Titled Asura level King's Cage qualifications which hadn't been seen in 3000 years could only qualify for a cherry seed-sized Demon God Bone. This was just too cheap!
"I'm sorry, but I am not interested!"
"You!!" Maha was now burning with anger. "Lin Ming, let me give you some advice. People shouldn't be too greedy, because the greedy always die. In Skysplit Tower, haven't you obtained Blood Demon Crystals, practice resources, pills, treasures, jade slips, and all sorts of other things? Now you are even allowed to leave in peace without spitting out everything you've taken!"
A cold light flashed in Lin Ming's eyes. He no longer used a true essence sound transmission and said clearly and loudly, "Skysplit Tower is a land that anyone can enter. You said that I obtained a massive amount of Blood Demon Crystals, practice resources, pills, treasure, jade slips, and what else? Well, that is not wrong! However, this is not granted to me by Skysplit Tower, but it is what I have earned through my life and death battles! What does any of this have to do with you?
"This Skysplit Tower was not constructed by you Giant Demons, nor the Imps, nor the Fey! It has stood tall here for 100,000 years. Several tens of thousands of years ago, this land was once the common resource of all the martial artists of the Holy Demon Continent. But some people relied on their powerful strength and united all the different powers, making all of the budding talents their minions. They called themselves High Lords even as they amassed wealth and stole away control of Skysplit Tower's great resources. They created all sorts of rules making it so that other martial artists have to slaughter each other to reach them, all in order to obtain the tiniest chances, and why is it that they are allowed to do that?"
Lin Ming's questions were shouted out, stunning all of the martial artists around him.
Lin Ming's words naturally made sense. It was just that these people had long accepted the High Lords' rules. It wasn't that they wanted to accept them, but that they had no choice but to.
These people present were not the High Lords' subordinates nor had they signed soul contracts. As they heard Lin Ming say all this, their hearts were in uproar.
Maha's complexion turned ugly. "Good! Very good! Since that's the case then there's nothing more to say! Don't regret your words in the future!"
"When I decide something, I never regret it!"
"Remember your words!" Maha coldly snorted and stomped off.
According to the rules of Skysplit Tower, Lin Ming truly did have the authority to enter the King's Cage. No one could stop him.
Skysplit Tower's High Lords were truly afraid of this. The current Lin Ming wasn't already impossible to control. If he entered the King's Cage, then he would undoubtedly grow.
The growth of a new human Divine Sea Supreme Elder was not something that any of the other races wished to see.
After Maha left, the surrounding martial artists were still confused. The conversation that Lin Ming had with Maha was mostly carried out in true essence sound transmissions. Since just a portion of that conversation was heard, none of them were sure what happened.
Lin Ming, without saying anything, lifted his foot and entered the door of light leading to the King's Cage.
In full view of everyone, Lin Ming's figure disappeared. The door of light shook, ripples spreading out over the surface just like a fish leaping into a pool of water. Then, this quickly calmed down, vanishing without a trace.
Today was the Dustnet Month, Sunlight Day.
This date was recorded down by Deacon Bai. It would be used to calculate just how much time Lin Ming spent in the King's Cage.
After Lin Ming disappeared, the surrounding martial artists naturally dispersed. Like this, the entire practice area was restored to its former calm…
Lin Ming felt his body shake as if he had jumped into a pool of water. A sense of icy cold hit him, and then he saw that he had arrived in a vast white space.
A distorted black ray of light appeared, spinning around Lin Ming. These black lights began to appear one after another, becoming more and more intense until they ultimately formed a completely enclosed cage around Lin Ming, sealing him within.
Lin Ming's mind went cold. This was the King's Cage.
At this moment, a voice passed into Lin Ming's mind. To be more exact, this wasn't a voice, but rather a form of direct communication that passed straight into the depths of his soul. Without words, without language, it allowed him to directly understand the meaning of it all.
"I'm supposed to break out of this cage. So this is what the King's Cage practice is like! Since it's like this, why do they say those people that stay in the King's Cage longer will experience more growth, and why would someone weak not even last 10 days before they are kicked out of this smelting trial space?"
Lin Ming had some doubts. Logically speaking, the less time it took to break out of the King's Cage, the stronger that person should be.
But the information he obtained was the opposite of that.
The weak could not stay in here long. But, the strong could stay as long as two months or more.
"There must be some trick to this place. I'll practice here and then figure it out as I go."
Lin Ming closed his eyes. A moment later, he took out the Purple Comet Spear. Above the spear shaft, azure true essence erupted.
"Break for me!"
Lin Ming gave a loud shout and stabbed out his spear at the cage's black barrier. There was just a slight 'kacha' sound as the black barrier suddenly trembled, but only a shallow mark was left. It was far from breaking apart.
"That's solid!"
Lin Ming's heart went cold. Besides opening the Heretical God Force or using the Concepts of Thunder and Fire, that strike had contained his full strength.
That strike should have been able to shatter an earth-step treasure armor. But when it hit the King's Cage, it only left behind a shallow mark.
"This should be normal too." Lin Ming wasn't surprised. If he could break through with just a single spear thrust, then there wasn't much meaning in this.
The Heretical God Force opened. Lin Ming also simultaneously used the Concept of Thunder.
Chasing Thunder!
Man and spear became one. Lin Ming turned into a purple light that smashed into the barrier.
With an explosion, thick arcs of electricity danced along the cage's walls like wriggling pythons. The King's Cage shook violently for a moment as several thin cracks appeared.
"It's broken?
"If it broke so easily… this King's Cage can't be that simple."
Chasing Thunder!
The black barrier that already had cracks in it could no longer withstand Lin Ming's continued attacks. Like a pane of glass, it suddenly shattered into countless small pieces!
The King's Cage broke!
The black barrier loudly collapsed, all of it disintegrating into powder before vanishing into the void. Lin Ming once again returned to that vast white space.
This empty white space was endless; it gave off an extremely depressing sense.
Xiu! Xiu! Xiu!
A series of sounds happened. Black arcs of light fell down on Lin Ming, wrapping around him and enveloping him once again. It quickly condensed into another black barrier, except this time it was much thicker.
Lin Ming instantly understood. That King's Cage from a moment ago had only been an appetizer.
The King's Cage smelting trial was divided into multiple levels!
The weak could only make it through a few layers, so they naturally stayed here for a shorter period of time. But a powerhouse could rush past many more, thus they stayed here a longer time.
"But… aren't there martial artists that don't break the cage and just spend months in here? Can't they stay here for a longer period of time using that method too?"
Lin Ming couldn't help but ask this question.
"It seems like the King's Cage is more complex that I imagined it to be. It absolutely can't be so simple!"
Thinking much more on this was pointless. He would slowly find out the further he got. What Lin Ming needed to do now was to break open this second prison cage.
The Heretical God Force opened once again!
"He refused?"
On Skysplit Tower's fourth floor, High Lord Shengong was looking at Maha as he calmly asked him a question.
"That ungrateful boy wants to do things the hard way." Maha bitterly said. He had taken the matter of Lin Ming publicly refusing him to heart.
"Shengong, I already said that the boy wouldn't be obedient. What can we do? We've even offered a Demon God Bone and yet he still refused! How can we possibly wait for that boy to become as strong as he wants before he leaves Skysplit Tower on his own volition? We might as well use this time when we are still stronger than him and carry out my plan!" In a corner of the hall, High Lord Heian was sitting in a chain, his fingers lightly rapping against his old wooden staff.
High Lord Shengong hesitated and slowly said, "I don't believe the promises of a human. Heian, you want to lock Lin Ming in the King's Cage until he dies, but how can we do that? We do not have the ability to alter Skysplit Tower's special practice areas."
"Rest assured, I have my methods." High Lord Heian cunningly smiled, his dark eyes as deep as the abyss.Previous Chapter Next Chapter


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Technological Inventions 2004 | When Technology Advances Supply
Technological Inventions 2004 | When Technology Advances Supply
The 4th year into the new millennium, 2004 was a leap year that was characterized by several technological inventions and innovations to address and improve the technological needs of man. In this column of our blog, we are going to look into some of these technological achievements of the year 2004.
Top of our wanted list is FACEBOOK. The biggest social network of our time Facebook was invented and launched in February 2004. This technological achievement incorporates not only message sharing, but also sharing of information, images, audio and video files as well as connecting to billions of people worldwide
The google mail machine Gmail was launched in 2004 to provide electronic mail services.
Mozilla Firefox
This is an open source free web browser developed in 2004 by Mozilla foundation for surfing and accessing web pages.
Ipod Device
This is a portable mobile media player or device typically used to play and listen to audio musics.
Bluetooth Integration
This wireless technology for exchanging files and data's over short distance between mobile or computer devices came into force in 2004
Violight Toothbrush Sanitizer
This piece of bathroom tool was invented in 2004 by Violight Tech, a high-tech toothbrush holder that protect the toothbrush against bacteria and germs. Just pop the toothbrush inside the violight sanitizer, press a button, and the Violight washes the brush with ultraviolet light.
Verisyze Corrective Lens
Verisyse corrective lens, an invention of Staar Surgical was invented to fix near-sightedness that is too severe for a laser surgery . The corrective lens is implanted between the cornea and the iris through some 6-mm incision to remove and eliminate any form of complications such as infections or cataracts.
Hungarian Architect Aron Losonczi did what many never believed is possible by inventing a LitraCon in 2004. LitraCon is a transparent concrete formed by mixing fibre optic glass and cement together which permits light to pass through it to create a surreal effect. LitraCon is as strong as the normal and regular concrete wall.
Wireless Technology Surfboard
Technological giant INTEL invented a a unique Wireless Technology Surfboard in 2004 which enables the user to take pictures, videos, send mails and also surf the web.
3M Novec 1230 Fire Protection Fluid
3M Novec 1230 Fire Protection Fluid which is an invention of 3M Technologies is a liquid-like fluid that looks like and flows water but doesn't get objects wet, rather it is invented to put our fires in offices, museums, and computer rooms and laboratories.
Snow Boat
Witnessing the loss of close friend or relative could trigger a great technological invention. Scenario as this spurred Harney Harry to invent a Snow Boat that can afloat even when the ice breaks during ice-skating.


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Spinal cord injury (SCI) affects 1.3 million North Americans, with more than half occurring after trauma. In Brazil, few studies have evaluated the epidemiology of SCI with an estimated incidence of 16 to 26 per million per year. With the aging of the population, the incidence is expected to increase, mainly due to fall-related injuries. Direct lifetime costs can be as high as $1.1-$4.6 million per patient, and the consequences for the patients and their families can be devastating1,2.
Search strategy
A PubMed search for articles published up to September 2016 was performed using the terms "Spinal Cord Injury" [Mesh] and ("traumatic" [Title/Abstract]), which returned 4,346 articles. Additionally, the reference lists of the most recent guidelines on the management of spinal cord injury were searched. Two reviewers independently screened the article titles and abstracts. Articles with at least one abstract in English or Portuguese were searched.
The initial primary trauma causes mechanical injury to the spinal cord, a combination of compression, laceration, distraction or shearing. After the resulting damage to the microvasculature, progressive edema develops, ongoing ischemia worsens and a pro-apoptotic signaling is initiated. There is disruption of the blood-spinal cord barrier, influx of inflammatory cells, vasoactive peptides, and release of coagulation factors. These events promote thrombosis and spasm of the microvessels, leading to further hypoxia. An energetic crisis is installed, there is production of oxygen free radicals, and excitotoxicity and cytotoxic edema develop. With loss of the parenchymal volume, cystic cavities coalesce, generating a physical barrier to cell migration. Because of the distortion of the structural framework, regenerative attempts do not succeed. Proliferation of astrocytes and deposition of fibroblasts worsen the picture. The Rho-ROCK (rho-associated protein kinase) is activated and inhibits neurite outgrowth. Together, all those mechanisms contribute to the restriction of regeneration1,2.
The final extent of spinal cord damage results from primary and secondary mechanisms that start at the moment of the injury and go on for days and even weeks. Neuroprotective agents attempt to avert specific secondary injuries and prevent neural damage, while neuroregenerative therapies act to promote axonal regrowth after the damage has occured1.
Neurological classification
After initial general stabilization, it is important to perform a thorough neurological examination. The American Spinal Injury Association (ASIA) standard for neurological and functional classification is the recommended preferred tool. It is important as a means of standardizing the initial and follow-up examinations, and also has a role in predicting the prognosis3.
The tool consists of two components, the sensitive and the motor. The sensitive component comprises the testing of a key point in each of the 28 dermatomes (from C2 to S4-5) on the right and left sides. Light touch and pinprick sensation are also tested. Each modality is separately scored on a three-point scale, ranging from 0 (absent) to 2 (normal or intact).
The motor examination encompasses testing of key muscle functions corresponding to ten paired myotomes (C5-T1 and L2-S1). Voluntary external anal sphincter contraction should also be tested. The strength should be graded according to the Medical Research Council grading system, from 0 to 5.
With that, the neurological level of injury is determined as the most caudal segment of the cord with intact sensation and antigravity muscle function strength (Figure 1).
The ASIA Impairment Scale should be determined, as follows:
A = complete. No sensory or motor functions in sacral segments S4-S5.
B = sensory incomplete. Sensory but not motor function is preserved below the neurological level of injury including S4-S5 and no motor function is preserved more than three levels below the motor level on each side of the body.
C = motor complete. Motor function is preserved below the neurological level, and more than half the muscles below the neurological level of injury have a muscle grade less than 3.
D = motor incomplete. Motor function is preserved below the neurological level, and at least half the muscles below the neurological level of injury have a muscle grade > 3.
E = Normal. Sensation and motor functions are normal in all segments tested4.
As previously mentioned, the ASIA Impairment Scale score has a prognostic value. Eighty-five percent of ASIA A patients will not regain function. Of the 15% who will improve, only 3% will have useful motor function. More than half (54%) ASIA B patients, and the vast majority (86%) of ASIA C-D patients will regain function5.
According to the last SCI guideline, trauma patients who have complaints of neck pain, spinal tenderness, symptoms or signs of a neurological deficit related to the spine, and patients who cannot be clearly assessed (the ones who are unconscious, uncooperative, incoherent or intoxicated) need a radiographic study of the spinal cord3.
The National Emergency X-Radiography Utilization Study (NEXUS) protocol was designed as an attempt to identify those at low risk for cervical fracture/subluxation/dislocation. It consists of five criteria: no posterior midline cervical tenderness, no intoxication, normal mental status, no other painful injuries and no neurological deficits. Patients meeting all of these criteria are at low risk of cervical injury and imaging of the neck or the spinal cord can be waived. The NEXUS protocol has a sensitivity of 99% and a negative predictive value of 99.9% for cervical spinal cord injuries6.
Another protocol addressing the same issue is the Canadian C-Spine Rule, which consists of three questions: the presence of a high-risk factor that mandates radiography (age > 65 years, dangerous mechanism of trauma, or paresthesias in extremities), the presence of low risk factors allowing safe assessment of the range of motion, and the ability to actively rotate the neck 45º to the left and right. The use of the Canadian C-Spine Rule protocol resulted in 100% sensitivity for cervical spinal injury with a 42.5% specificity7.
The imaging modality of choice is computed tomography (CT). If it is not available, a three-view spine x-ray is recommended (anteroposterior, odontoid and lateral views), being supplemented later by a CT scan3.
Magnetic resonance imaging should be obtained, when feasible, in the first 48 hours after the trauma. It can detect lesions in 6% of the cases in which the CT is normal, and is particularly useful for ligamentous lesions. It is also a valuable tool to classify severity and predict outcome based on the presence of hemorrhage, extent of edema, and severity of the initial compression. Intraspinal hemorrhages (> 1cm long) as well as longitudinal T2 signal changes > 3cm, are associated with poor prognosis. A normal initial magnetic resonance image is usually associated with complete recovery8.
Airway management
Respiratory complications are the main cause of morbidity and mortality in the acute phase of the SCI, with incidence ranging from 36% to 83%. Reduced vital capacity, retention of secretions, and autonomic dysfunction all play a role. Up to two thirds of patients will have complications such as atelectasis, pneumonia, or respiratory failure that require mechanical ventilation9.
The injury level and the ASIA classification are the two most important predictors for the need of intubation. Virtually 100% of lesions above C5 require intubation (the phrenic nerve originates from C3-C5), which should be performed electively rather than as an emergency. It is important to avoid hyperextension, rotation, and other movements of the neck during intubation. When possible, awake, fiberoptic intubation is preferred. In-line stabilization without traction is an alternative when a fiber optic laryngoscope or bronchoscope is unavailable9.
In selected patients with complete cervical lesions or in those with incomplete or lower lesions, conservative management might be an option. In such cases, lung function should be monitored closely with vital capacity, maximum inspiratory pressure and carbon dioxide partial pressure levels. Those measures can predict the need for intubation9.
With regard to ventilator weaning, only 40% of patients with lesions above C4 are successfully extubated. Predictors of the need for tracheostomy are ASIA A lesions, extent of the lesion, smoking, and previous lung disease. Some studies advocate that early tracheostomy (within 10 days) in these patients leads to a shorter ICU stay and reduction in the length of time of mechanical ventilation10.
Cardiovascular management
Hypotension after SCI is frequent. It may be due to hypovolemia in a context of polytrauma, or due to the direct cervical or thoracic spinal trauma itself, leading to neurogenic shock. Neurogenic shock results from the interruption of sympathetic tone due to disruption in supraspinal control, and an intact parasympathetic influence via the vagus nerve, leading to an imbalance in the autonomic control. There is, therefore, loss of peripheral vascular tone and bradycardia11.
Although the deleterious consequences of hypotension in SCI have not been assessed in a controlled prospective way, there is convincing evidence that hypotension contributes to secondary injury after acute SCI, reducing spinal cord flow and perfusion. Based on this, the current recommendation is to strictly avoid hypotension, and maintain mean arterial pressure (MAP) at 85-90mmHg for seven days after injury (level III evidence)3. In order to achieve that goal, the mainstay of treatment is intravenous fluid therapy (mainly with crystalloids) to maintain a euvolemic or slightly hypervolemic status, in association with vasopressors2. It is important to have invasive blood pressure monitoring with an arterial line.
The main predictors of poor cardiovascular function requiring resuscitation and support are high cervical and complete lesions12. Cardiovascular instability may be transient and episodic, but can also be recurrent in the first 7–10 days after injury.
The best vasoactive amine is still a matter of debate. The last guideline does not address this controversy. A systematic review tried to answer several questions regarding the use of vasopressors in acute SCI. However, it was inconclusive in determining which vasopressor is better, what the optimal therapy duration is and what the MAP level is below which one should initiate vasopressor support13.
The vasopressor selection may depend on the level of the SCI and on the patient's hemodynamics. In cervical or high thoracic lesions with both hypotension and bradycardia, a drug with chronotropic and inotropic effects as well as vasoconstrictor properties might be required. Norepinephrine (or alternatively, dopamine) could be good options. For low thoracic lesions, where hypotension is usually the result of peripheral vasodilation, a pure vasopressor drug such as phenylephrine could be appropriate14.
Recently, some studies have addressed the frequency of side effects and rates of complications related to the use of vasoactive drugs in this population. A high rate of cardiogenic complications was found, with up to 70% of patients experiencing at least one of the following: tachycardia, bradycardia, elevated troponin, new onset atrial fibrillation, atrial flutter, or eletrocardiogram ST changes consistent with ischemia. A higher rate of side effects with the use of dopamine compared to norepinephrine and phenylephrine was described, especially in the population older than 55–60 years15,16,17.
Recently, Altaf and collaborators compared the effects of norepinephrine versus dopamine on MAP, the intrathecal pressure (monitored with a lumbar intrathecal catheter) and spinal cord pressure perfusion (the difference between MAP and intrathecal pressure). The conclusion was that norepinephrine was able to maintain MAP with a lower intrathecal pressure and correspondingly higher spinal cord pressure perfusion18.
These findings have led to a non-inferiority trial design called the "Mean Arterial Blood Pressure Treatment for Acute Spinal Cord Injury", comparing the avoidance of hypotension (MAP ≥ 65mmHg) versus the induction of hypertension (MAP ≥ 85mmHg), which is currently recruiting patients and is expected to be completed in 201719.
Decompressive Surgery
Progressive edema and hemorrhage contribute to the ongoing mechanical pressure on the microvascular circulation. Surgical decompression aims to relieve this pressure, thereby reducing secondary hypoxia and ischemia2.
Indications for surgery include significant cord compression with progressive neurological impairment and a fracture not amenable to, or not responding to, close reduction, such as unstable vertebral fractures.
The Surgical Timing in Acute Spinal Cord Injury Study was a prospective, observational study that compared patients who had undergone surgery before and after 24 hours from injury. The first group was more than twice as likely to have a two grade ASIA Impairment Scale improvement and a similar complication rate compared to the group with late surgery20.
Those findings were confirmed in a prospective Canadian cohort study even after adjusting for preoperative status and neurological level21.
With that, the concept of "time is spine" has emerged, and the ongoing recommendation is surgical decompression in the first 24 hours3.
The SCI-POEM is a European multicenter study that is currently recruiting patients with the aim to compare decompression < 12hours versus > 12 hours until 14 days. The final report is planned to be published in the end of 201722.
Intravenous methylprednisolone
Methyprednisolone (MP) is a synthetic corticosteroid that upregulates anti-inflammatory factors and decreases oxidative stress, enhancing endogenous cell survival in animal models of SCI. It reduces edema, prevents intracellular potassium depletion and inhibits lipid peroxidation1.
Since the 1980s, clinical trials have been trying to demonstrate its benefits in humans. The National Spinal Cord Injury Study I, published in 1984, examined 1000mg bolus MP followed by the same dose daily for 10 days, compared to 100mg bolus and then daily. No difference in motor or sensitive neurological recovery was observed between groups, and wound infections were more prevalent in the high-dose group23.
The National Spinal Cord Injury Study II, published in 1990, compared MP 30mg/kg intravenously followed by 5.4 mg/kg/h over 23 hours to naloxone and placebo. At one year, there was no significant difference in neurological function among the groups. A subanalysis found that the subset of patients who received the corticosteroid within eight hours had a modest improvement in motor recovery. Wound infections were more frequent among MP patients24.
The National Spinal Cord Injury Study III, published in 1997, compared three treatment groups: MP for 48 hours, the same drug administered for 24 hours and tirilazad mesylate (a potent lipid peroxidation inhibitor). Patients were treated within eight hours of SCI. In a post hoc analysis, in patients treated between three to eight hours from trauma, the 48-hour regimen was associated with a greater motor, but not functional, recovery. In addition, the group with the longer duration had more severe sepsis and pneumonia25.
Recently, a meta-analysis and systematic review concluded that evidence from multiple randomized controlled trials and also from observational studies do not support methylprednisolone use in acute SCI since it has no long-term benefits. Besides, it increases gastrointestinal hemorrhage and has a trend to increase overall adverse events26.
The last consensus does not recommend MP for treatment of SCI3.
Neuroprotective agents aiming to reduce secondary insults are potential key therapies in SCI. Multiple approaches have been studied, and many others are currently under investigation.
Gangliosides are glycolipid molecules present in neuronal membranes. Laboratory studies have shown that they can enhance axonal regeneration, besides having a variety of neuroprotective effects, such as prevention of apoptosis and anti-excitotoxic activity. GM-1 (Sygen) was suggested as a therapeutic option until the 2002 guideline (although without demonstrated clinical benefit)27. However, a randomized controlled trial of the ganglioside compound reported no difference in neurological recovery after six months, therefore, it is no longer recommended3,28.
Naloxone, an opioid antagonist, was tested in the National Spinal Cord Injury Study II trial together with MP and placebo. The study was negative, with no differences in motor scores between groups24.
Nimodipine is an L-type calcium channel blocker thought to prevent calcium- dependent apoptotic enzymes and block presynaptic release of glutamate. In comparison with placebo, however, no difference in neurological status at one year was noted29.
Tirilazad mesylate, a drug that attenuates peroxidation of neuronal membranes, was analyzed together with MP in the National Spinal Cord Injury Study III trial, with no difference between groups. There are no placebo-controlled studies25.
In animal studies, hypothermia decreased basal metabolic rate in the central nervous system, reduced inflammation, apoptosis, excitotoxicity, edema, gliosis, and increased angiogenesis. As well, traumatic SCI models showed improvement with the decreased temperature30. A small pilot study in humans with SCI exposed to hypothermia showed a trend towards neurological recovery (43% vs 21%) and no difference in complication rates31. Another study evaluated 35 ASIA A patients who were treated with hypothermia (33ºC) for 48 hours, starting in the first six hours post-injury. Four patients converted to ASIA B in the first 24 hours. In the remaining patients, 35.5% showed an improvement of at least one grade on the ASIA scale at the latest follow-up32.
These promising results led to a phase II/III trial named "The Acute Rapid Cooling Therapy for Injuries of the Spinal Cord". This study (which is not yet recruiting) plans to evaluate different durations of hypothermia, starting within six hours post-trauma.
*Paralysis TMPtC: Neuroprotection: therapeutic hypothermia; 2014. Assessed August 2016.
Riluzole, a sodium-channel blocker, reduces secondary injury by blocking pathological activation of sodium channels and reducing the release of glutamate in preclinical models of SCI. A phase I/II trial demonstrated a benefit in motor scores in patients treated with the drug33. A phase II/III trial, the Riluzole in Spinal Cord Injury Study, is ongoing, to evaluate the aforementioned drug in cervical lesions. It will be completed in 201834.
Minocycline is an antibiotic with anti-inflammatory properties including inhibition of tumor necrosis factor alpha, interleukin 1 beta, cyclooxygenase-2 and nitric oxide synthase. In pre-clinical models, it decreased lesions sizes and neuron loss. In a phase II study, the ASIA motor score improved in patients treated with minocycline (p = 0.05)35. This led to a phase III trial, the Minocycline in Acute Spinal Cord Injury, which is currently recruiting patients until 201836.
Fibroblast growth factor has been shown to protect against excitotoxicity and to reduce free radical production in animal models of SCI. A fibroblast growth factor analogue called SUN 13837 was evaluated in a phase I/II trial completed in 2015, but results are still pending37.
Cytokine granulocyte colony stimulating factor is neuroprotective in SCI by promoting cell survival and inhibiting tumor necrosis factor alpha and interleukin 1 beta. There were two small, non-randomized studies that demonstrated improvements in ASIA motor scores with the drug use38,39.
A wide number of strategies are being developed worldwide to help recovery in SCI patients. There are numerous targets and therapeutic opportunities using endogenous and exogenous repair mechanisms. The aim is to surpass barriers to recovery such as the loss of structural framework, cystic cavitation, scarring and inhibitory molecular signaling2.
Cell-based therapies are promising modalities of regeneration. A wide number of cell types have been studied or are being evaluated in ongoing studies – embryonic stem cells, induced pluripotent stem cells, olfactory ensheathing cells, Schwann cells, mesenchymal cells, and activated autologous macrophages. In preclinical studies, cellular transplantation alone, or in combination with other therapies, was associated with neurological recovery, without any subtype showing superiority over the other. Small human studies also disclosed some degree of improvement, with no major adverse events. However, it is important to notice that, independent of treatment, most patients will undergo some spontaneous recovery in the first six months after injury. Therefore, confounding factors cannot be excluded from these results1.
Embryonic and induced pluripotent stem cells are capable of remyelinate axons, modulate the inflammatory response, regenerate lost neural circuits and modify the microenvironment. Schwann cells are able to remyelinate central nervous system axons and, in animal models, have reduced cystic cavitation, enhanced tissue sparing and enhanced recovery. Olfactory ensheathing cells are phagocytes capable of clearing microbes and debris and also of secreting neurotropic factors. In animals, they enhanced axonal regeneration and remyelination and also improved outcomes. Mesenchymal cells can differentiate along their connective tissue lineages and modulate inflammatory response at systemic and local environment levels. They have been shown to decrease inflammatory cell infiltration, increase pro-survival trophic factor levels and promote tissue sparing1,2.
It should be noted that cellular transplantation remains an investigational and experimental therapy, with no formal recommendations.
Spinal cord injury management has substantially changed over the last years. Key early interventions are increasingly being recognized, as well as the need to better study these patients. Neuroprotective and neuroregenerative strategies are probably more effective when done together, and they are an extensive field of current and future research. The pending trial results can have a significant impact on the standard of care, given that even small motor or sensory improvements can have profound effects on patients' lives.