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Did you know...
Traveling Trunk Owned by Baron de la Roche, 1964.79.1
This beautiful traveling case was once owned by Baron de la Roche who was an aide de camp to Lafayette during the American Revolution. He was born in Treves, Germany in 1757 and raised there though his family was originally French. He attained the rank of officer in the American army and in 1790 de la Roche became an American citizen. Later he returned to Europe and was killed in the in the Battle of Austerlitz, one of Napoleon's greatest victories. At the time of his death in 1805, he was listed as a member of the Society of the Cincinnati, an order exclusive to former generals to Washington and their descendents.
Baron de la Roche's finely-made, veneered traveling case dates to the 1770s and may have been used during the Revolution. It is unusually well fitted-out and includes 2 traveling brass candlesticks, a covered silver powder box, a silver sponge box, a silver soap dish, a silver shaving pan, a silver shaving basin, five silver trays, a razor, razor strap, a wooden wig curler; 2 glass toilet bottles (one with liquid), an Anglo-Irish cut-glass dish, a glass funnel, a snuff box, needle case, pen case with quills, 2 French porcelain lidded jars, a tin kettle with a detachable handle for boiling water, large tin can for holding wig powder, a small tin box with wool batting, a large tooth comb, and an etched wine glass. The chest has a drawer with multiple compartments for letters and other documents. In addition, the razor strap bears the label of the Parisian retailer of the chest, firmly connecting it with de la Roche's time just before the Revolution. Taken together, these objects document not only de la Roche's high-style taste, but what one gentleman of position and rank regarded as necessities.
This case is currently on display in our exhibition Inventing a Nation: Maryland in the Revolutionary Era.


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Betterliving Sunrooms roof panels with white exterior have qualified for Energy Star® rating in all 50 states.
Betterliving is proud to be an Energy STAR partner!
In order to participate in the Energy Star Partnership Program, Craft-Bilt Manufacturing Company had to submit sample panels to an accredited testing facility. Not only does the test facility perform physical tests, it also runs computer simulations for verification of the results. ENERGY STAR is a government-backed program helping businesses and individuals protect the environment through superior energy efficiency. Energy efficient choices can save families about a third on their energy bill with similar savings of greenhouse gas emissions, without sacrificing features, style or comfort. ENERGY STAR helps you make the energy efficient choice.
Betterliving Sun rooms doors and windows are GOLD LABEL CERTIFIED! The gold labels on Betterliving sun rooms let you know that the doors and windows were tested and passed the ratings standards adopted by the Fenestration Manufacturers Association. The labels certify that the product has passed the rating standards specified in the Voluntary Specifications for Aluminum, Vinyl (PVC) and Wood Windows and Glass Doors.
Since 1962, the American Architectural Manufacturing Association's (AAMA) Certification Program - the original third-party window performance verification program - has provided the industry's highest standards to evaluate product performance. Its distinctive "gold label" is accepted, if not required, by many federal, state and municipal building codes and administrators - providing an assurance of quality to builders, dealers and homeowners. Betterliving products carrying the GOLD LABEL have passed the following tests:
A voluntary partnership between the US Department of Energy, the US Environmental Protection Agency, product manufacturers, local utilities and retailers. When properly installed, Energy Star-labeled products can save consumers 10%-40% on heating and cooling bills each year.
The Industrial Fabrics Association International (IFAI) is a not-for-profit trade association representing the entire spectrum of the specialty fabrics industry.
Craft-Bilt has received confirmation from the National Evaluation Service that it's PanelCraft® structural roof panel complies with 2000 ICC codes as well as BOCA National, ICBO Uniform and SBCCI Standard codes. ICC-ES came into being on February 1, 2003, when America's four building–product evaluation services officially combined their operations. The four "legacy" evaluation services that came together to form ICC-ES were the National Evaluation Service, Inc.; BOCAI Evaluation Services; ICBO Evaluation Service, Inc.; and SBCCI Public Service Testing and Evaluation Services, Inc. Through the legacy evaluation services, ICC-ES has a history that goes back more than seventy years.
The National Fenestration Rating Council is a non-profit, public/private organization created by the window, door and skylight industry. It is comprised of manufacturers, suppliers, builders, architects and designers, specifiers, code officials, utilities and government agencies. NFRC provides consistent ratings on window, door and skylight products. NFRC's primary goal is to provide accurate information to measure and compare the energy performance of window, door, or skylight products.
Uniform Evaluation Services (UES) has been a leader in codes and standards development since 1926. It was built upon an 88 year old foundation of experience, expertise and quality.

subset: commoncrawl


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Mike Morse doubled and homered as Chien-Ming Wang won his second straight. [WaPo]
Davey Johnson says the Nats are moving Morse back to LF. [All Nats]
Davey also says Ryan Zimmerman called his shot last night. [Nats Enquirer]
Awesome column about the Nats' big four draft signings. [Tom Boswell]
Some speculation about the Nats' September call-ups. [Nats Journal]
Brian Roberts still doesn't have a timeline for his return. [O's Insider]
John Beck is ready to start against Indy on Friday night. [The Insider]
Doc Walker is replacing Joe Theismann in the booth on Friday too. [Bog]
Sounds like RB James Davis just up and left Redskins camp. [The Insider]
The Haynesworth waitress-groping case gets a little spicier. [Crime Scene]
Rocky McIntosh, Sean Taylor implicated in the Miami scandal. [The Insider]
Maryland's opener against Miami probably just got easier. [Testudo Times]
A good look at new Maryland football coach Randy Edsall. [Mike Wise]
Ted Leonsis' $20M purchase was this year's 2nd-biggest sale. [Curbed DC]
For $795k you can live next to Ovechkin. [Russian Machine Never Break]
Can't believe you guys didn't nominate us for this. [CBS Washington]


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Either Diane Kruger is possibly engaged [1] to longtime boyfriend Joshua Jackson [2] or she's just a lucky girl sporting a gorgeous new diamond ring. Either way, it's not just the new sparkler that caught our attention — the fashion pro also wowed with a cool-girl look while out to dinner with her beau. Keeping proportions slouchy and casual but no less sexy, the actress outfitted easy leather trousers with a textural striped sweater. The trick to making these pieces date-night appropriate? Do as Diane did and just add hot red heels.
Shop clockwise from top left: Zara Leather Effect Trousers [3] ($80), H&M Mohair Blend Sweater [4] ($60), Alice + Olivia Dina Suede Pumps [5] ($282, originally $402), Kate Spade Sedgewick Place Avalon Bag [6] ($298)
Get a peek at the new jewelry!


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This is your resource to discuss support topics with your peers, and learn from each other.
10-06-2012 06:54 AM - edited 10-06-2012 07:04 AM
How to profile BB10 Native application?
I interested in function execution time table to find most expensive ones.
Thanks in advance!
10-06-2012 07:19 AM - edited 10-06-2012 07:29 AM
What should I do to get to work Execution Time view?
This that I see after profiling starts: data collection is actually not happening


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I was correctOriginally Posted by kidhuman
I was correctOriginally Posted by kidhuman
thanks Chux Turbo LBC Bobafrett Mtriv73 Rjarvis JF96 JT JMG FB Rogue2 Tycho Slicker Deoxy Caesar JontheJedi JJReason Brandon Solo JMS UK for great deals.
SSG Pro Football Pick em and Bowl Pick em Champ 2006. 2007 NCAA Bracket Champ
#24 - Gone but not forgotten
kidhuman is kingOriginally Posted by ukwildcat
"That's the best deal you're gonna get. I won't tell you you can save yourself, because you can't."


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Rocky Hill, CT Pizza Restaurant
Rocky Hill Pizza Restaurant
Welcome to Rocky Hill Pizza Restaurant, home of Connecticut's best pizza! We offer fast free delivery for all of Rocky Hill, Cromwell and Wethersfield. Our specialties are delicious gourmet pizzas, calzones, grinders, salads, and Italian dinners.
We have a spacious, comfortable dining room, where you can eat in or give us a call for take out or delivery.
Contact Rocky Hill Pizza Restaurant today at 860-563-5111 for take out or delivery.
Hours of Business:
Mon-Thu 11:00am-9:00pm
Fri-Sat 11:00am-10:00pm
Sun 12:00pm-9:00pm
Mon-Thu 11:00am-9:00pm
Fri-Sat 11:00am-10:00pm
Sun 12:00pm-9:00pm
Methods of Payment:


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A Puerto Rican youth is on trial for murder, accused of knifing his father to death. The twelve jurors retire to the jury room, having been admonished that the defendant is innocent until proven guilty beyond a reasonable doubt. Eleven of the jurors vote for conviction, each for reasons of his own. The sole holdout is Juror #8, played by Henry Fonda. As Fonda persuades the weary jurors to re-examine the evidence, we learn the backstory of each...more
OK for kids 12+
Read reviews
All 12 Angry Men cast + crew photos


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Submit your comments on this article |
Syria-Lebanon-Iran |
Clash Breaks out between Rival Factions in Ain el-Hilweh |
2013-01-02 |
[An Nahar] Clashes erupted in the Paleostinian refugee camp of Ein el-Hellhole on Tuesday between rival factions, reported various media outlets. Voice of Leb radio (100.5) said that a clash broke out at dawn between members of the Resistance That'd be the Hezbullies, natch... Brigades, loyal to Hizbullah, and youths from the Popular Nasserite Organization. The National News Agency reported however that an armed clash broke out between a Paleostinian member of Jund al-Sham and another from the Fatah movement. Two grenades were also tossed in the clash. The security committee at the camp soon intervened and restored calm. Earlier on Tuesday, NNA said that unknown assailants also tossed two hand grenades in Ein el-Hellhole's vegetable market where Paleostinian youths were celebrating the New Year. |
Posted by:Fred |
#2 OOOOPPPPSSS, forgot WORLD NEWS > [Siasat Daily] UN ENVOY WARNS "100,000 COULD DIE IN SYRIA IN 2013" AMID CIVIL WAR. and * WAFF > [Gateway Pundit]ISLAMIC CLERIC [Wahhabi Preacher] ISSUES FATWA ALLOWING JIHADIS TO RAPE SYRIAN WOMEN. IIUC ARTIC, NOT JUST RAPE BUT SO-CALLED "GANG/ GANGBANG/BUS/TRAIN" RAPE + FORCED SEXUAL MULTI-CONCUBINAGE??? The good news is that the Artic = Fatwa? didn't specify Muslim-vs-Non-Muslim Syrian women. Are we missing Baby Assad now??? |
Posted by: JosephMendiola 2013-01-02 22:47 |
#1 I suspect new Groups = Factions will be joining the Camp + inter-Militant shennanigans soon ... * TOPIX, DEFENCE.PK/FORUMS > TALIBAN VOW SUPPORT [$$$, fighters]FOR REBELS, SHARIA STATE IN SYRIA. * SAME > SYRIAN AL-QAEDA DECLARES WAR AGZ HEZBOLLAH, SHIAS [Local, Regional], + IRAN. versus * SAME > SYRIAN BROTHERHOOD VOWS TO COUNTER AL- QAEDA. * TOPIX > DE BORCHGRAVE: EGYPT WILL BE THE NEXT IRAN. * TOPIX > IRAN: IRGC OUTREACH [recruiting] IN PERU. The Peruvians are coming, the Peruvians are coming! * DEFENCE.PK/FORUMS > [YouTube = Syria Rebel Watch] VIDEO: FSA REBELS SING SONG OF PRAISE FOR OSAMA BIN LADEN + CELEBRATE 9-11. IIRC VIDEO = "How sweet the Memory of 9-11/the Day the Twin Towers fell ...". |
Posted by: JosephMendiola 2013-01-02 22:27 |


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What to Watch For: Pens vs. Canadiens
by Michelle Crechiolo / Pittsburgh PenguinsPENGUINS (30-19-4) vs. CANADIENS (20-24-9)
WHEN: Feb. 7, 2012 - 7:30 pm | WHERE: Bell Centre
WATCH: ROOT SPORTS | LISTEN: Penguins 24/7 Radio, 105.9 FM
Max Pacioretty has seven goals in his last 10 outings. (Getty Images) |
The Habs dug a hole for themselves with a rough first half of the season, causing the organization to resort to a number of different tactics to get the proud Habs back on track. The Canadiens began by removing bench boss Jacques Martin and replacing him with interim head coach Randy Cunneyworth, but it didn't provide the spark they hoped for as Montreal is just 7-11-2 since the change.
GM Pierre Gauthier then traded skilled sniper (and clutch playoff performer) Michael Cammalleri to Calgary last month for sizeable winger Rene Bourque, who produced back-to-back 27-goal seasons from 2009-11. Bourque has just two goals in his nine appearances with the Canadiens while playing right wing on the second line with Andrei Kostitsyn and Tomas Plekanec.
But despite their dismal outlook for the remainder of this season, the silver lining is that Montreal's lineup is fraught with plenty of developing young talent that's been contributing to the best of their abilities – and it's third-year forward Max Pacioretty who is leading the charge with seven goals and 10 points in his last 10 outings. If the Canadiens really are out of the playoff race, expect to see the youngsters continue to get more ice time. But with that being said, Montreal needs to see more from its veterans like Plekanec, Kostitsyn, Scott Gomez and Erik Cole.
Montreal has struggled on the man-advantage this season, as their power play ranks 29th in the NHL. But their penalty kill has been a bright spot in an otherwise disheartening season as it ranks No. 1 in the league. The Canadiens, led by shorthanded specialist Hal Gill, have killed off 89.7 percent of their opponents' power plays – and chipped in their sixth shorthanded goal of the season on Sunday against the Jets.
Cole produced an outstanding performance against the Penguins in the two teams' last meeting, where he scored a goal and an assist in Montreal's 5-4 shootout loss. Overall, he's got four points (2G-2A) in the three meetings between the clubs. The Habs forward may be pointless in his last four outings, but he's still one of Montreal's best producers as he's tied for the team lead with 19 goals. Not only does Cole have great skating ability and a gritty style of play, but he's got a tireless work ethic that's sure to be on display Tuesday as he looks to help get his team on the right track.
Look no further than Malkin as the Penguin that will spearhead the team's rebound from their lackluster 5-2 loss in New Jersey on Sunday. Malkin is known to elevate his game when it matters most and has been clutch for the team all season, so don't expect anything less from 'Geno' on Tuesday. It helps that the highly competitive center is already on an offensive roll. With his gorgeous power-play goal against the Devils, Malkin has now scored goals in 11 of his last 14 contests (14 goals total) and has points in 20 of his previous 25 games (20G-17A) dating back to Dec. 8.
A win by the Penguins would give them their first perfect sweep of the Canadiens. On two previous occasions – 1998-99 (3-0-1) and 1992-93 (2-0-1) – they have finished with unbeaten records against Montreal.
Pittsburgh's 3-0 record against the Canadiens thus far ensures they will finish with a winning record against Montreal for the fifth time in seven seasons. During that span the Penguins are 16-8-3.
The Penguins are 4-1-1 in their last six games at the Bell Centre. In their last three they are 2-0-1.
Penguins goalie Marc-Andre Fleury has proven to have a short memory when it comes to being pulled from games. Since the beginning of the 2009-10 season, Fleury has responded from getting pulled from games to go 9-1-1 with a 2.25 goals-against average and a .927 save percentage in his next start. Last season, Fleury went a perfect 3-0 in such situations with a 2.27 goals-against average and a .908 save percentage. In '09-10, Fleury was 6-1-1 with a 2.24 goals-against average and a .933 save percentage.
Center Jordan Staal and defenseman Simon Despres, both working through knee injuries, returned to team practice Monday at the Bell Centre in Montreal.
Staal and Despres are on similar timeframes for rehabbing their knee injuries and returning to game action. Head coach Dan Bylsma placed each in a 5-10 day period.
However, the team also learned that it will be without forward Tyler Kennedy, who left Sunday's game in New Jersey late in the third period after falling awkwardly into the boards, for the foreseeable future as he returned to Pittsburgh to be re-evaluated for a lower-body injury.
In addition, Penguins center Sidney Crosby (diagnosed with a soft-tissue injury in his neck, which is positive news for all) skated with his teammates at practice Monday at the Bell Centre, but there has been no change in his status and he has not returned to full team practice.
Crosby, who is still experiencing symptoms, opted to skate with the team as opposed to skating on his own as the lone non-practicing injured player.
F Arron Asham, illness/concussion-like symptoms (10)
C Sidney Crosby, concussion-like symptoms (26)
D Simon Despres, knee (13)
C Jordan Staal, knee (15)
F Michael Blunden, lower body (2)
F Brian Gionta, torn biceps (11)
D Andrei Markov, knee (53)
F Travis Moen, upper body (5)
F Petteri Nokelainen, upper body (6)
F Ryan White, lower body (53)
Author: Michelle Crechiolo


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About Us
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Leading Just Associates is a team of professionals with extensive MPI and EMPI database knowledge and Health Information Management (HIM) expertise. With a staff of fully-credentialed HIM professionals with years of experience in HIM department operational and management, Just Associates understands our clients' needs and is well-equipped to improve health data quality for organizations of all sizes.
Beth Just, MBA, RHIA, FAHIMA – President, CEO and Consultant
Beth founded Just Associates in 2002 and has grown it into one of the industry's leading providers of data integrity services that minimize the ongoing cost of maintaining patient data quality.
With more than 30 years of experience in the HIM sector, including executive-level positions at QuadraMed, Pyramid Health Group, New Era of Networks and Quality Visions, Inc., Beth brings to Just Associates a unique blend of HIM and technical expertise, including database and software design and management. Beth's strengths include project management, business development, healthcare business and operations management, product management and financial management. While her pragmatic business techniques, technological know-how and strong knowledge of the healthcare industry bring a unique value and quick return on investment to the clients she serves. Beth has completed hundreds of consulting engagements including MPI clean-ups, Patient Access assessments, MPI assessments, HIM operational reviews and EMPI needs assessments, and RFP development, as well as software development, testing and implementation projects for healthcare organizations, multi-facility IDNs and RHIOs.
She has served in several officer, board and chair positions for AHIMA and the Colorado Health Information Management Association (CHIMA) and contributed to the "HIM Principles in HIE" and "Patient Identity in RHOs" workgroups. Beth was appointed co-chair for AHIMA's Health Information Exchange Practice Council in 2008 and is the past president of the Colorado HIMA. In 2014 Beth was asked to serve on the AHIMA Information Governance Task Force which will continue through the end of 2015. She was also recognized as the 2015 Colorado Health Information Management Association's "Distinguished Member."
Beth has also been a featured speaker at numerous State and National professional meetings including AHIMA, HIMSS and TEPR, as well as a number of software vendors' user group conferences (Cerner, Microsoft, IDX).In addition, she has authored and been quoted in articles published in the Journal of AHIMA, For the Record, Healthcare IT News and Modern Healthcare. She was the lead author on AHIMA's Practice Brief: HIM Principles in Health Information Exchange.
Beth earned her Bachelor of Arts at College of Saint Scholastica and her Master in Business Administration at the University of Colorado.
Jerry Just – Sr. Vice President
Jerry is responsible for the leadership and strategic direction of Just Associates' corporate branding, marketing and business development. With more than 30 years of experience in sales, sales management and marketing within the healthcare field, Jerry has helped several venture-capital-backed medical device startups grow to the point of acquisition by companies such as Eli Lilly and Boston Scientific.
Prior to joining Just Associates, Jerry served as regional sales manager for Interventional Technologies, area business manager for Datascope and the vice president of sales and marketing for Quality Visions. His experience spans the markets for both disposable and capital medical equipment as well as information technology software and consulting services. Jerry earned his Bachelor's degree in Business Administration with an emphasis in Marketing from the University of Wisconsin and his Master in Business Administration from the University of Phoenix.
Lora Hefton, PHR - Chief Operating Officer
As Chief Operating Officer, Lora is responsible for managing all hands-on operational aspects of the company. Guided by the objectives of the organization, she provides the leadership and management necessary to ensure that the company has the proper operational controls, administrative and reporting procedures, and people systems in place to increase growth the organization, financial strength and operating efficiency. Before serving in this role, Lora served as V.P. of Human Resources and Business Services as well as business manager for Just Associates.
Lora has more than 21 years of experience in the technology sector, excelling in positions ranging from marketing to executive and regional sales administration. Prior to joining Just Associates, Lora served as the product marketing manager at Microsoft. Lora holds a Professional Human Resources certification from the HR Certification Institute and has completed a number of advanced training courses in professional development and effectiveness. She earned her associate's degree in Business Administration from Barnes Business College and is currently working towards completion of a Bachelor's degree in Business Administration.
Emilie Paternoster, RHIA - Vice President, Eastern Regional Sales
As Vice President of Data Integrity Services, Emilie oversees the sales and contracts operations for Just Associates Data Identity Integrity and Consulting departments. With more than 35 years of experience in healthcare management in a variety of healthcare settings, Emilie has worked with a number of clients, assisting them in evaluating their EMPI/MPI strategies and technology. She possesses strong project management skills and has successfully managed projects ranging from the selection and implementation of EMPI technology to MPI cleanup and MRN conversion projects. Emilie also possesses considerable experience in client management and has served in various roles for large IT vendors, providing solutions to healthcare providers.
Emilie is a member of AHIMA, was president of the Delaware chapter of AHIMA from 1985 to 1986 and the Maryland Health Information Management Association from 2011 to 2012. She has also chaired numerous State committees. On a National level, Emilie served as the chairperson for the Council on Public Affairs and the chair of the Ad-Hoc Task Force on the Prospective Payment System. She earned her Bachelor's degree in Health Information Management from York College of Pennsylvania.
Karen Proffitt, MHIIM, RHIA, CHP – Vice President, Identity Enterprise Solutions
As Vice President of Consulting Services, Karen oversees the day-to-day operations of Just Associates' consulting services. She is also responsible for strategic development of new services and solutions that leverage the firm's unique data integrity capabilities to serve evolving market needs. Karen has more than 30 years of experience in HIM, with a strong expertise in electronic health records, EMPI management, Epic implementation, medical record document management, legal/privacy issues and data governance.
Karen is a member of AHIMA. At the state level, she served as a director for the Colorado Health Information Management Association in 2008 and was president of the Tennessee Health Information Management Association from 1997 to 1998. Karen is past president of the Upper East Tennessee Health Information Management Association and the Mid-East Tennessee Health Information Management Association. She also served as the education chair on medical records for INSIGHT, a HIS user group, from 1994-2000. Karen earned her Bachelor's degree in Medical Record Administration and her Master in Health Information/Informatics from the University of Tennessee.
Joseph D. Gradecki – Vice President, Development and Security Officer
Joe is responsible for managing Just Associates IT infrastructure and developing ID
, the firm's proprietary duplicate record workflow software that facilitates the accurate resolution of duplicate records in the most efficient manner. He has recently become Mirth certified He is also a key member of Just Associates' business development team.
Prior to joining Just Associates, Joe worked as chief architect at Raytheon. He has also worked in a variety of industries including defense, finance, consulting and 'dot.com' startups. Joe is an accomplished technical writer with 11 books published by John Wiley and Sons, Inc. He holds a BS and MS in Computer Science and is currently working toward his PhD in Computer Science from the University of Denver. Recently, Joe has become Mirth certified.
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Just Associates, Inc. Provides MPI Clean-Up Services, Including Cleaning Duplicate MPI Records.
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AT&T Wireless Officially For Sale
Jan 22, 2004, 9:28 AM by (staff)
AT&T Wireless today confirmed that it has received numerous takeover bids, and is seriously considering them. Official bids are said to have been received from Cingular and NTT Docomo, while Vodafone and Nextel are reportedly also interested. AT&T Wireless has retained financial and legal firms to assist with the process, although the company said today "there can be no assurance that any transaction will occur." The company also postponed its annual analyst meeting, to be rescheduled "at a later date as appropriate."
if cingular took over..~~


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liverish is a valid word in this word list. For a definition, see the external dictionary links below.
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Cardiac results of confinement, Lich hypertrophy and fibrosis. Conditional KO HDAC3 in cardiomyocytes was no provision during the dramatic rise in lipid storage from the ligand-induced heart. FAK ligand Mice surviving three 4 months, at which stage they showed significant cardiac hypertrophy acids and depression genes embroidered slow down the absorption of fat and metabolism. Mice offered both HDAC5 or HDAC9 lebensf compatibility offered, are w Throughout Mice, the place each genes t Dlichen ventricular septal defects and thin-walled myocardium, have generally come from abnormalities during the development and maturation of cardiomyocytes. The transcription factor, MEF2, is often a target for these HDACs. HDAC4 KO showed hypertrophy of chondrocytes and die ??berm Owned bone formation, suggesting that HDAC4 has an r Central purpose in the formation from the skeleton. Vega et al. showed that HDAC4 interacts with and suppresses RUNX2 and MEF2C, the two to inquire a embroidered vital part in chondrocyte hypertrophy and with bone formation.
Within the absence of HDAC4 are uncontrollable, the transcriptional activation of these variables EAA ??berm what Strength ossification. HDAC7 KO is embryonic lethal on account of loss of blood provide. HDAC8 Knockout Mice are lebensf compatibility out there, but have craniofacial defects. HDAC6 Knockout Mice are lebensf compatibility available without the need of obvious Ph Genotype, au He obtained for Hte tubulin acetylation. HDAC10 and HDAC11 KO hasn't been reported. clomifene These different Ph knockout phenotypes Predict the side effects of HDAC inhibitors isoforms the clinical director from the greatest techniques for drug improvement. By way of example, considerable cardiac adverse results in some sufferers have already been vorinostat and depsipeptide that observed with heart defects in HDAC2, are three, 5 or 9-knockout M Correlates use are actually reported. In addition Tzlich can HDAC7 selective inhibitors beneficial for the inhibition of tumor angiogenesis. Ph removal device HDAC genotypes are summarized in Table three.
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All Entries Tagged With: "ASK Homework"
Ball Towers HD Review for iPad
Posted by Gwen Phua | Jun 20, 2011 | Comments 0
ASK Homework recently updated their physics game, Ball Towers HD. In this game for the iPad, your mission is to roll a steel ball along a ramp that will curve this way and that, and finally, to drop the ball into the basket at the end. While the objective is simple, the game is anything but. Because it will challenge your dexterity. Continue on to iPadmodo for the full review.Read More


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Imagine crossing a one-lane stone arched bridge into the quaint German village of Maeystown, Illinois and staying at the Corner George Inn Bed & Breakfast, a restored 1884 hotel and saloon. Located just 39 minutes south of St. Louis in the Mississippi River bluffs, the inn offers six charming antique appointed guest rooms including whirlpool and loft suites, country and Victorian rooms, and a summer kitchen guest cottage. Corner George Inn also features: Corner George's Inn Sweet shoppe that offers hand-dipped ice cream, baked goods, beverages and more.
Address: 1101 Main Street, Maeystown, Illinois 62256
Phone: 618.458.6660
Hours: Open year round
The Sweet Shoppe specializes in hand dipped ice cream of the finest quality, baked goods, beverages and gift items.
Address: 1105 Main Street, Maeystown, Illinois 62256
Phone: 618.458.6660
Explore the charm of the past in a restored building that once was home to a harness & saddle shop/general store. Georgia Mae's carries a variety of antiques and collectibles, including glassware and much more.
Address: 1103 Mill Street, Maeystown, Illinois 62256
Phone: 618.458.6660
Our shelves are stocked with antique ware, primitives and country commodities.
Address: 1101 Main Street, Maeystown, Illinois 62256
Phone: 618.458.7000
Hours: Seasonal hours
*Check Facebook for current hours
Home of the Preservation Society and Visitors Center. The Maeystown Preservation Society is a not-for-profit organization and its mission is to preserve the history, culture, customs, architecture and structures of the village of Maeystown, Illinois. The Mill is available for rental for birthday parties, reunions, anniversaries, showers, etc. The Rock Mill is fully heated and air-conditioned and situated on attractive, spacious grounds and adjacent to the Maeystown Creek.
Address: 1113 Main Street, Maeystown, Illinois 62256
Mailing Address: PO Box 25, Maeystown, Illinois 62256
Phone: 618.458.6464
Hours: Saturday: 10:00am to 5:00pm
Sunday: 12:00pm to 5:00pm
*All other times by chance or appointment
A complete and enjoyable tavern experience with food and spirits. We stay with the true tradition of a tavern…great food and welcoming hospitality! Our banquet room will hold up to 175 people.
Address: 1026 Main Street, Maeystown, Illinois 62256
Phone: 618.458.6444
Hours: Thursday and Friday 5PM – 8PM, Saturday 8AM – 8PM & Sunday 8AM – 7PM
Colonial Style Tea Room and Gift Shop located in the heart of historic Maeystown, Illinois and within walking distance to local shops and bed and breakfast. Open during Maeystown events and most Saturdays! Tea room may be reserved privately for rehearsal dinners, bridal and baby showers, birthday parties, ladies groups, and special events. Seating capacity inside up to 20 and front porch seats 10. Free Wifi!
Address: 1109 Main Street, Maeystown, Illinois 62256
Phone: 618.539.3665
Hours: Saturday 11:30am-2:30pm
* Open during all Maeystown events
We are a micro-coffee roasting company and coffee shop. We only roast our coffee fresh. We also roast and blend some very nice chicory blended coffees, of which may be purchased in gound/blended or as LiL' Red Smooth Brew. Our mission is to offer the freshest coffee, and the best customer service. Too make you feel at home! We offer a very relaxing atmosphere which includes a beautiful stone patio and a very beautiful stone fireplace. A great place to forget your troubles! We also offer SerendipiTea, Dr. Smoothie products, Umpqua Oats, Market Fresh Pizza, Burito Kitchen buritos, and a whole lot more. Free Wifi!
Address: 1103 Main Street, Maeystown, Illinois 62256
Phone: 618.458.8088
Phone: 618.975.4740
Hours: Saturday & Sunday 7:30am-5:00pm


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text:
The skeletal script amounts to little more than a series of monologues--a group standup routine -- in which Barry's (Marc Smollin) relatives relate their woes in life and why they dislike the rest of the family.
The skeletal script amounts to little more than a series of monologues–a group standup routine — in which Barry's (Marc Smollin) relatives relate their woes in life and why they dislike the rest of the family.
The conflict appears in the form of Mafioso stereotype Angelico (Sam Zap), who arrives to collect on a loan made by Barry's father (Mark Lonow), presumably to pay for the bar mitzvah. Inevitably, the family covers the debt and the show ends happily for everyone except the audience. A climate suggesting active audience involvement manifests as each member is greeted upon arrival as a valued guest of the family. This introduction proves misleading, with interjections from the audience being met by the confronted cast member with the canned response, "We'll talk about it later." Though total participation may never have been the intent, the interaction that occurs is a tease– more afterthought than convention–leaving the audience floating in a kind of limbo between participant and spectator. The show renders two acts of every cliche and stereotype about Jewish people imaginable, from stinginess to nose jobs. Joel Reed and Mansour Pourmand's script overflows with off-color comedy, with most of the sex humor serving as a crutch employed by the playwrights to compensate for the text, or lack thereof. The cast, under Pourmand's inept, clueless direction, goes down with the Titanic. Inoffensive performances from the valiant and cute Smollin and the innocuous Lonow are drowned in the deluge of hamming and bad acting. At the show's opening, one eagerly hopes it would be good. They say, "You don't have to be Jewish to love 'Barry Moses' Bar Mitzvah.' " If one were Jewish , one might be insulted by this piece of ridiculing tripe. In fact, this reviewer isn't, but was.Barry Moses' Bar Mitzvah
(Hyatt Sunset; 140 capacity; $ 68 top)
A Shiman Prods. presentation of a play in two acts by Joel Reed, Mansour Pourmand; director, Pourmand.
Lights, Peter Straus; sound, Jack Allaway; costumes, Alix Hester. Reviewed Sept. 22, 1992; runs indefinitely.
Morris Moses ... Burt Goodman
Gilda Moses ... Melissa Berger
Danny Moses ... Mark Lonow
Sammy Moses ... Michael D. Edelstein
Sadie ... Lila Teigh
Saul ... Randy Swerdlick
Barry Moses ... Marc Smollin
Doris ... Diana Harvey
Tante Rivka ... Sparkle
Angelico Campazzi ... Sam Zap
Similar in flavor to the interactive hit "Tony and Tina's Wedding," but not in taste-- an attribute this production lacks completely--"Barry Moses' Bar Mitzvah" ranks, or reeks, near the bottom of the current theatrical offerings in L.A. While advertisements for the show read, "You don't have to be Jewish to love" the show, most of the sparse humor hinges on culturally "inside" jokes, leaving much of the audience, including many "insiders," out.


text:
2012-06-06, 22:17 | Link #264 |
Senior Member
Join Date: Dec 2010
Location: Puerto Rico
@blue: I remember seeing that pic. I think it was either with the chapter 2 weeks ago, or last week's chapter.
@ran: Although I won't do it, you may get many negative rep points due to your post. Be warned.
2012-06-07, 00:40 | Link #266 |
Senior Member
Join Date: Dec 2010
Location: Puerto Rico
I'm not blaming you for that. I'm just saying that after the chapter from 2 weeks ago plus the animé, many users treat Erza like a beautiful goddess. The picture may throw the idea that you may be bashing her, even though that wasn't your intention.
2012-06-17, 11:48 | Link #273 |
Awe of She
Join Date: Dec 2005
Location: Orlando
*laughing my ass off* Oh wow, so much hawtness and so much lol-ness. Ah...I'm hyperventaliating...XDDD
Drawing Erza in the Neko-oufit from the OVA was great. And Juvia has gotten 10 thousand more fans with that image. I really want to be in Mashima's studio when it's time to draw - must be the most hilarious place on earth. ~*~ "Okay, so I got Jenny's nude spread drawn out and the two old guys enjoying oggling her. What else can be done? "I know, have it so that her Blue Pegasus guys also posed nude." "With her!?" "NO! in separate photo shoots! And have Macao and Waka turn the page and -BAM- full frontal male nudity." "Oh god..." "Not only that, have their families walk in on them at EXACTLY that same time." "...you guys are evil. I knew I hired you for a reason!!!" "Wait, it needs something else..." "What else?" "Needs Fried in there." "Huh? for what?" "Have him openly oogling the guys." "WHAT!? I didn't plan on him being like that!" "Oh please, it's how he ended up! Why else do you draw him blushing whenever he's with Laxus!?" "...oh the hell with it, sure why not! And I'll even throw in a poster of Laxus behind him." "Now you're talking!!"
Last edited by Tempest35; 2012-06-17 at 12:08. |
2012-06-17, 18:39 | Link #276 | |
Awe of She
Join Date: Dec 2005
Location: Orlando
It's clips like this that make Fairy Tail so damn fun to read. And to watch too - the English Dub is pretty damn good in many respects.
2012-06-18, 17:33 | Link #279 | |
The One Eyed King
Join Date: Apr 2009
Location: Lurking Up Ahead
Spoiler for Manga... NSFW... COLORED:
---- Spoiler for Manga Only:
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text:
Directed by Hong Seong-chang (홍성창)
Screenplay by Hong Jeong-eun (홍정은), Hong Mi-ran (홍미란)
SBS | Airing dates : 2009/10/07~2009/11/2616 episodes - Wed, Thu 22:00
When a nun-in-training masquerades as a boy and enters the (almost) all-male world of a pop idol band, love, fireworks, and much confusion follows. "You're Beautiful" is hilarious fun with a solid grounding in romance and emotional heart, and unfolds with the Hong Sisters' creative trademark flair. The innocent, young Go Mi Nam has never interacted with the "real world"; after she and her identical twin brother are abandoned as children, she grows up in a convent. Today, she is training to become a nun. After her brother successfully auditions to become the newest member of pop group A.N.JELL, all that changes. When her brother suddenly disappears to the U.S. to reverse a botched plastic surgery, his manager desperately decides to enlist Mi Nam to play the part of her brother until he recovers. Mi Nam, unwilling to give up on the dreams of one of them becoming famous and finding their mother, reluctantly agrees. The innocent almost-nun has no idea what she's in for, particularly when it comes to Hwang Tae Kyung, the neurotic, prickly band leader who opposes her joining the band. When the other members, kind Shin Woo and lovable Jeremy, fall under the spell of their newest member, things start to get complicated. And when Mi Nam herself starts to feel strange sensations toward reserved, perfectionistic Tae Kyung, who has his own set of parental issues, chaos ensues. Punctuated by original music and propelled by the pitch-perfect performances of its main leads, "You're Beautiful" is an enjoyable romp from start to finish.
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text:
- Score:
- rated 4.19 / 5 stars
- Views:
- 232,982 Views
- Share Links:
- Genre:
- Action - Shooter - Multidirectional
- wizard
- zombies
- bloody
- undead
Credits & Info
- Uploaded
- Feb 27, 2012 | 10:00 AM EST
- Frontpaged February 27, 2012
- Daily 2nd Place February 28, 2012
- Weekly 5th Place February 29, 2012
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Author Comments
An Evil Wizard has taken over London, and is using an army of Zombies to do his bidding. You take control of Rupert Whitewater a man who stands up to the evil reign. In this action survival game, you will have to learn effective and brutal special moves to strike down your foes. Develop tactics, and purchase perks to become the ultimate zombie killing machine.
Newgrounds Edition!
Includes Medals and multiple Scoreboards so you can show how much better you are than everyone else.
Quick Update
- Fixed MIRACLE SHOT! Medal
Update v1.3
- Fixed bug where you could buy skills without having their prerequisites
- Fixed up Medal: "Legend" (To obtain: Finish the game without ever starting an area without Nightmare mode on. If you already have just clear game data under options and relaunch the game)
- Fixed glitch with shooting and killing zombies that have been knocked to the ground
- Fixed bug where you could damage the Wizard while he's in the air vulnerable with kicks and zombie heads
- Fixed problem with the "Most Kills (in a day)" scoreboard where it let people submit scores for endless rounds
- Added new scoreboard called "Total Kills"
- Modified the way the Ammo display is updated in hopes of fixing it's glitch
- Made the gun icon on the HUD change depending on what weapon you have out
Update v1.2
- Fixed Medals: Wipe Out, Wipe Out Nightmare, ALL THE SKILLS, GIVE EM' THE BOOT, Dodging Fish and That wasn't so hard
- Fixed problem where keys weren't releasing properly
- Fixed bug where the Wizard could disapear off the map when charging
Rated 3.5 / 5 stars
The idea is awesome, but I don't want to spend 6 hours beating the game. It should be a less expensive (like $100) to fortify areas, but aside from the time frame, great game!
Rated 4 / 5 stars
Although I think zombies should be killed by an head shot. It's still a good game.
Rated 2 / 5 stars
I was going to give a good rating, but the fact of the matter is that the only really good to play this game is to earn as many medals as possible. Also, the wizard at the end was WAY too hard, and even when I learned his patter, by the time Rupert got the Wizard to kick his sorry ass into the acid, the Wizard would usually just disappear. All of that work, and I can't even see whether Rupert saves his family or not. Good riddance.


text:
Starting out JAVA in MAX – send message directly to object
I have just installed eclipse and got it running with MAX:) I have used Javascript in the past but need something that performs better so this is why I am starting to use JAVA. I used to access objects directly from javascript using the following syntax:
objline1 = this.patcher.getnamed("sn_line1");
Is it possible to send a message directly to an object using JAVA?
Hi. No, this isn't possible from Java, you need to send out of an outlet and route appropriately…
Ok. Thanks for the advise. Do you happen to know of any good tutorials apart from the "Writing Max Externals in Java" pdf?
Also when sending to an outlet can I please ask you to advise how to format the message. I am sending the string below to a play object but it did not understand it.
import com.cycling74.max.MaxObject;
public class PlayFragment extends MaxObject {
public void bang() {
String str ="start 100 2000 1900";
Yo KMLL,
You need to parse the values you want to output as "Atoms" ( the generic datatype that Max uses ), build an Atom[] array from those values, then output the array.
This is how I go about it:
String someString = "allTheThings";
float someFloat = 0.4f;
Atom[] outputAtom = new Atom[] { Atom.newAtom ( someString ), Atom.newAtom ( someFloat ) };
outlet ( 0, outputAtom );
yup, that.
As for additional tutorials, don't know of any of hand, but didn't look that much. found the pdf to be informative enough. i'm guessing if you hunt around for emamples of other people's code that may help you.
Thank you both for the input:)
I studied the API in more detail yesterday and it seems that it is actually possible to send a message direcly to an object. Here is an example:
MaxPatcher p = this.getParentPatcher();
MaxBox mb = p.getNamedBox("sn_play1");//The script name needs to be set in the inspector
Atom[] outputAtom = new Atom[] { Atom.newAtom (200), Atom.newAtom (500),Atom.newAtom (300)};
mb.send("start", outputAtom);
well, thanks. i've learnt something new today also :)
btw, if you look in the java/classes directory under your MAX install, there are a number of java files in there that do basic things
Thanks for the pointer to the files:)
KMLL, you wonderful person, you.
I've seen this question a few times and the response was always "it can't be done". This will save me from having to route all over the place. Well done and many thanks!
Yes, it's possible to send messages between Java objects without using patch cords.
Doing so will make it well-nigh impossible to debug your patches unless you document the holy shit out of what you're doing. Which you won't.
Sending messages through patch cords means you have to draw the patch cords, but then you can see the connections in your patch. With invisible connections: you make one change, nothing works, and you can spend many long and tedious hours trying to figure out what's gone wrong.
If you want your code to be reusable, if you're working on a project that's supposed to last and develop over more than a week, then stay away from this trick. But if your time is worth nothing at all, go ahead and be it on your head.-)
Thanks for the input on this thread you all. Glad I could help Chris:) Guess Peter has a good point but it is a matter of coding style I guess. Also I have to warn any readers that I found the API to be inadequate when interacting with certain objects e.g the line object but I have created a seperate thread about this issue. – Thanks
Also I have to warn any readers that I found the API to be inadequate when interacting with certain objects e.g the line object
there's nothing wrong with the API in this regard.
you just have to know that a list, e.g. 20 200, is a message starting with the (mostly hidden) message header list. i.e. 20 200 and list 20 200 is basically the same.
so in java you can use the send(java.lang.String message, Atom[] args) method to send a list to a max object, like this:
int args[] = {20, 2000}; MaxPatcher p = this.getParentPatcher(); MaxBox mb = p.getNamedBox("sn_line1"); mb.send("list", Atom.newAtom(args));
hope that clears it up.
As Volker said, you can use send(java.lang.String message, Atom[] args)
. There is also MaxSystem.sendMessageToBoundObject(java.lang.String sym_name, java.lang.String msg, Atom[] args)
As mentioned in your other thread about sending messages to line
, it may be easier to use the overloaded methods for java primitive types than using the atom
versions–performance is better too.
Yes, it's possible to send messages between Java objects without using patch cords.
Doing so will make it well-nigh impossible to debug your patches unless you document the holy shit out of what you're doing. Which you won't.
I totally agree with Peter, but if you do document everything well, you can do many quite powerful things messaging between Java objects. Using the two methods mentioned above maybe have some performance and threading issues vs some of the methods available for using your MXJ's outlets. You can even build stuff that doesn't use the Max API but passes around references to Java objects if you really want to get into crazy town.
int args[] = {20, 2000};
MaxPatcher p = this.getParentPatcher();
MaxBox mb = p.getNamedBox("sn_line1");
mb.send("list", Atom.newAtom(args));
I get the following error from the code above….
"cannot find symbol
symbol : method send(java.lang.String,com.cycling74.max.Atom)
location: class com.cycling74.max.MaxBox
mb.send("list", Atom.newAtom("test"));"
This error is a bit weird as it seemed to come and go, now it is always there.
I was also wondering if it's possible to name the MaxPatcher something other than p?
Like so…
MaxPatcher mypatch = this.getParentPatcher();
MaxBox pattr = mypatch.getNamedBox("pattr_object");
Forums > Java


text:
June 2, 2009
"One guy that was home at night was Batman."
Just one item from a list of the best of Theme Time Radio With Bob Dylan. I love that radio show. I love satellite radio. And Bob Dylan. And now, I guess, Batman. Are you staying home tonight? I am. But I don't think I could be Batman. Or even Bob Dylan. Do you?
(Posted at Instapundit too. Just felt like cross posting. Because I'm staying home tonight and I got the notion.)
15 comments:
- Meade said...
I see. Staying home and relaxing in the notiony cute zone.
- jjm said...
I am staying at home grading summer calculus tests. Ugh!
Iron man was the best. It was a nice tech fix. Make a cool set of armor and go after bad guys! Batman was way too athletic for me. - 6/2/09, 8:51 PM
- chickenlittle said...
Althouse contemplates Meade, pre-Meade: Link
- Jay Vogt said...
Not quite as good but almost, is the excellent Marty Stewart's American Odyssey
- traditionalguy said...
Perhaps the Althouse clan started as cave dwellers, who became evolved Hippies, and finally adapting to their environment,developed into Blogger People living in cyberspace caves at night. But what great fun they have emerging every morning.
- Jason (the commenter) said...
I think Batman is kind of lame. I'd rather be Mary Worth. Think of the lives you could destroy with those meddling powers!
- Theo Boehm said...
In 3-1/2 short hours I'll be ready to talk metaphysics on Twitter with Batman.
Batman could understand metaphysics. Batman could quote Pascal and discuss Kirkegaard if it came to it. It seldom did, but you knew he could.
Then Spiderman came along, and he wouldn't stop talking existentialism.
You always knew those superheroes would wind up as senior faculty: Batman and Spiderman in the Philosphy Dept., and Superman over at the Physics Dept. - 6/2/09, 9:37 PM
- Sheepman said...
Thanks for the link.
You know I don't usually like to tell people what I'm doing, but I am talking to a couple of car companies about possibly being the voice of their GPS system. ...
You don't need a Bob Dylan
To know which way the car goes - 6/2/09, 9:38 PM
- jayne_cobb said...
I am unfortunately too poor to become Batman, so I'll probably have to settle for Blue Beetle</a , just without the whole being shot in the head and replaced with a hispanic teenager in an attempt diversify the hero community thing (hopefully).
- Revenant said...
The whole "I could be Batman" thing is also the explanation for the UNpopularity of the Robin character. As a kid, you can see yourself maybe being a Batman kind of guy one day. But Robin's a kid and he's just plain better than you. Lame!
- EDH said...
Actually, the quality Dylan feels he shares with Batman is that he was "at home in the night," not "home at night," as in tucked into his little jammies.
Speaking of which, I remember receiveing the metal Batman lunchbox when I started kindergarten, coinciding with the release of TV show.
It's like a flashback seeing once again pictures of all those action vignettes that were on the side of the lunchbox and thermos. The images were burnt into my brain long ago, having studied them so hard while I ate the Wonder Bread sandwiches that my mother had made and removed the crusts from at my insistence.
I even remember the generic schoolyard safety tips on the inside of the luchbox.
Meanwhile, earlier that year, Bob Dylan had released Blonde on Blonde and crashed his Triumph 500 motorcycle. I didn't know who he was then, but I came to know him through his music a decade late.
I never said "I want to be Bob Dylan," Batman, Mr. Jones (or Adam Duritz, for that matter). But twenty years later, I got to be around Dylan through work for the first time.
Come to think of it, he is a little like Batman -- the dark, reclusive one, not the campy TV lunchbox Batman. - 6/2/09, 11:19 PM
- XWL said...
You can't be Bob Dylan, but you can be any (or all) of the Beatles you choose (with the exception of Pete Best).
(and in actuality, you can already be Bob Dylan, but just for one song, "Tangled Up in Blue", to quote the wiki "The song is a playable track on Rock Band 2, the most difficult song in the vocal section, and the final song for the player to complete in the "Impossible Vocal Challenge".") - 6/3/09, 12:29 AM
- ricpic said...
Batman was dark.
Dylan was dark.
Two wild and fabulous guys (in their own minds).
Superman on the other han' was light.
The bringer of light.
Which made him square. The guy from nowhere.
Well, that's the way it was...and always will be.
At least none of them ever wore a Trilby. - 6/3/09, 2:09 AM
- Ann Althouse said...
1. I'm pretty sure Dylan was doing a transition from a song about staying home at night. (He's dj-ing.)
2. Batman really does stay home, brooding in his mansion, waiting for the signal.
3. Batman is not "at home" in your sense of the term anywhere. He's uneasy and troubled. Not having a good time, even when out in the night kicking criminals' asses. - 6/3/09, 6:34 AM
- Largo said...
I'd like to see Batman with Samurai Jack. Jack could be cool in the DC universe.


text:
Two Free Doritos Games Now Available On XBLAWritten Wednesday, December 08, 2010 By Richard Walker View author's profile |
Following in the big dinosaur-shaped footprints of Doritos Dash of Destruction, Microsoft has released two more free Doritos branded XBLA games, each with an unlockable gamer picture, multiplayer support and of course, 200 Gamerscore's worth of achievements.
Both games are a result of Microsoft's US-based Doritos promotion that invites people to submit their ideas for games, the best of which get made into an XBLA game. Doritos Crash Course is a multiplayer platformer that has 15 levels of obstacle-laden challenges to complete as your Avatar.
Harms Way meanwhile is a multiplayer racing game that pits drivers against snipers, with the drivers having to complete 3 laps to win as the snipers attempt to blow up the drivers before they manage to reach the finish line. Head over to Xbox Live now to add Doritos Crash Course and Harms Way to your download queue. They're free!


text:
Bridgetown (Barbados): Mar 18, 2013
West Indies selectors have named an unchanged 13-man squad for the second and final Test against Zimbabwe starting Wednesday at Windsor Park in Dominica.
The hosts won the opening Test at Kensington Oval by nine wickets inside three days on Thursday.
West Indies Squad:
Darren Sammy (captain), Denesh Ramdin (vice captain), Tino Best, Darren Bravo, Shivnarine Chanderpaul, Narsingh Deonarine, Shannon Gabriel, Chris Gayle, Veerasammy Permaul, Kieran Powell, Kemar Roach, Marlon Samuels, Shane Shillingford.


text:
I didn't get it, but check the French comments: Take the red pill
I created the deck for this week's elo, it's a variant of one that scored me my own Elo record of 1353e. The variants of these are probably the most powerful decks I've played with, and this particular one is obviously very viable.
I'll be trying my luck with it for the rest of the week as it'll be rare that Morphun, Marina, /and/ Striker will be released together again for a while.
Ignore the last 2 posts please.


text:
Soft Organizer 6.01 Portable | 7 Mb
A common problem we often face with, when uninstalling unnecessary software, is various traces left in the system: unneeded files or folders on a disk, registry entries and so on. This can happen even if an application was removed correctly with its own uninstaller - a special program provided by a vendor to uninstall the application. The Soft Organizer program is intended to solve this problem: It allows you to COMPLETELY uninstall unnecessary applications from your system.
Soft Organizer - utility to completely uninstall, search & remove traces when uninstalled, as well as check for new versions of programs. Also has a built-in software rating.
1. Very simple and intuitive operation
The simple, convenient, and non-overloaded interface doesn't distract a user from the installing and/or uninstalling process. The Soft Organizer utility looks like a simple list of installed programs, where a user merely needs to select a program and click "Uninstall". At the same time, the tool features the entire range of capabilities that even programs with much more complex interfaces have. (Most of those programs look like a space shuttle cockpit with many gauges, meters, and obscure instruments.)
2. Has only the functions you really need
Thanks to judicious selection of capabilities, Soft Organizer features only those options you really need in your work. The overall functionality of the program is similar to competitive application removal solutions.
3. Enhanced capabilities for experienced users
Due to the number of enhanced functions in Soft Organizer, experienced users can enjoy more precise control over the process. Such functions keep a low profile and do not distract other users, so installing and uninstalling applications using Soft Organizer remains simple and intuitive.
Search for traces (residues) of the uninstalled program
Allows you to remove traces of programs that were not tracked while installing (powered by the Full Uninstall technology).
Tracked installation of programs
Installs apps and tracks changes in the system to enable removing tracked elements later (powered by the Full Uninstall technology).
NEW! Built-in program rating
Program rating allows you to evaluate installed applications. The rating is calculated based on the total number of users who have removed this app from the computer shortly after installation.
Program description
If the purpose of some program in the list looks vague, you can view its description by clicking the special question icon near the program title (not available for all programs).
Check for new versions
For installed programs there's an option to check for newer versions of a program. This allows you to keep applications up-to-date, as well as to eliminate bugs and problems caused by the outdated versions.
Automatic restore points
Automatic creation of restore points during the removal of application residues indemnifies the system against any possible emergency.
Remove multiple programs at once
You can easily remove even multiple applications in Soft Organizer by simply selecting all programs you don't need anymore and clicking "Uninstall".
"Silent" program installation
For those setup packages that support silent install, you can install applications in the "no questions asked" mode in one click.
Export the list of installed programs to HTML
When you contact the support staff of a company, they may ask you about the programs installed on your computer. You can easily get such a list in a few clicks. The list is saved as an HTML file that is easy to open and to read.
Sorting and grouping of the list
The list of programs can be sorted by various parameters (install date, tracking status, title, and others) for instant search for given apps in the list.
Program quick search function
With quick search, you can find a desired application almost immediately, as long as you know its title or a portion of it. The list dynamically shortens as you type the text in the search box.
Agent to detect installer launches
The Agent allows you to detect if an installer is launched and initiate installation tracking without manually starting Soft Organizer.
Built-in automatic update mechanism
Soft Organizer automatically updates to new versions. You don't need to visit the website of the program or download or install the tool manually. You simply click the Update button, and the program does the rest.
Home Page -
- Code:
Title: Soft Organizer 601 Portable
Size: 7.5 MB | Format: rar
- Code:


text:
Three of the world's most influential newspapers have finally come to terms with the notion that charging readers online is the only way to survive.
There is far less agreement on how to go about that, the publishers of The New York Times, The Times of London and the Financial Times made clear at this week's Reuters Global Media Summit.
The New York Times Co's launch of its long-awaited online payment system early next year will be the latest effort to convince readers to pay for what they have come to expect free.
It will join News Corp's Times of London, whose own tests have achieved mixed results.
"We create very valuable, important content and we are trying to ensure we get fairly compensated for it," said News Corp Chief Operating Officer Chase Carey.
Carey and other top executives speaking this week at the Reuters summit are trying to calibrate prices and bundles of products that will not alienate advertisers, fearful of steep drop-offs in readers, and consumers, who are accustomed to free access.
News Corp also owns the Wall Street Journal, which remains one of the few newspapers to have generated a healthy online business from subscriptions over the past decade.
But the strategy, which worked well for a business publication, has failed to yield similar results for News Corp's most recent attempt to charge readers of the Times.
News Corp put all the news from the Times' website behind a pay wall, charging 1 pound for a day or 2 pounds for a week's access. Its online readership dropped by almost 90 percent.
Success will be measured over years, not a quarter, Carey said. "The media always want to declare judgment in a quarter."
The New York Times, on the other hand, will employ a different tactic. It plans to announce as early as January prices for its "metered" model, which will charge readers after they access a limited number of articles for free on NYTimes.com.
Arthur Sulzberger Jr, publisher of the New York Times, took pains to make clear the stark differences between the two papers' approach.
"Please don't compare us to the Times of London," Sulzberger said. "They have a gate, a real wall. We aren't doing that. To compare us to them is just a false comparison."
He added: "We want to be part of the digital ecosystem."
It will be the second major attempt for the New York Times to convince readers to pay, mindful of the publishing industry's challenge.
"We're going to test it. We're going to learn. We are going to adapt," Sulzberger said.
The U.S. and UK newspaper industries suffered an unprecedented decline in advertising spending that pushed papers into bankruptcy and resulted in thousands of job losses. Print papers and magazines have also competed with free digital news and entertainment venues for readers as circulation revenue has plunged over this period.
The New York Times dallied with a pay strategy in 2005, but pulled the plug by 2007 in its attempt to extract fees for access to TimesSelect, featuring its award-winning columnists such as Maureen Dowd and Frank Rich.
New York Times Chief Executive Janet Robinson called TimesSelect a "success" but said they ended the service in order to maximize its online readership.
The New York Times has spent the past year studying its proposed new metered model, finding ideas from telecom and cable companies, and even WeightWatchers, which charges users for in-depth diet tips.
"We know that we have the opportunity, particularly with the metered model, to manage this process," said Robinson.
Robinson did not detail plans for the strategy, but made clear there were distinctions between it and the Financial Times, from which it drew inspiration. The Pearson Plc-owned newspaper has charged people to read its news online since 2001.
Although the FT initially blocked all content from non-subscribers, the site switched to a metered model by 2007 that allowed people to read a set number of articles each month before asking for a fee.
Now digital revenue at the FT — which includes subscriptions and advertising — represents 20 percent of total revenue.
Speaking at the London arm of the Reuters Global Media Summit, FT Chief Executive John Ridding said digital subscriptions are steady and strong. These subscriptions have helped it collect valuable data from its customers.
"We can understand where traffic is coming from on a regional basis," Ridding said. "So that naturally increases the efficiency of the advertising."
This "efficiency" has enabled the FT to charge up to 10 times more for online ads tailored for its readers, Ridding said.
The more newspapers that start charging for online news, the better, Ridding said. "We've always believed that quality in journalism is worth paying for.


text:
Best Fiends Forever v2.1.1 (Mod)
Best Fiends Forever v2.1.1 (Mod)
Requirements: Android 4.1+
Overview: Get ready for the very big adventure with very small heroes! The sequel to the award-sometimes-winning-and-if-not-we're-just-happy-to-be-nominated Best Fiends!
But it's nothing like that game! Except that it's got the same characters, and you're still beating up slugs. But it's a clicker adventure, which is different, and we think a lot of fun!
* TRAVEL through the world of Minutia, beating up bad guys!
* SLAP, COLLECT & LEVEL UP pretty much everything in the game!
* LEARN MATH trying to understand how much damage you're doing!
* LOSE TOUCH with your family and friends!
* RECOMMEND it to people you don't like!
Story: The Fiends finally made it to Mount Boom, only to be defeated and imprisoned in very similar boxes. Now it's time for YOU to turn the tables! Round up the old gang, level them up and defeat wave after wave of slugs as you make your way to the elusive villain behind the Slug Invasion!
With the help of the Fiends, and the awesome reckoning power of Mount Boom, and the magical souvenirs that boost your strength, and whatever new stuff we come up with down the line, you'll save the world in no time. And then realize there's more to this game than even that! And then hate us for making a game you can't stop playing!
And there's no energy mechanics, you can play it whenever you want, for as long as you want! Which is good, since you've obviously got some time on your hands if you bothered to read this far through the description. So get it already. Best Fiends FOREVER!
– Unlimited Currencies. "Increase"
– Fast Level up.
– Cheat Detection Removed.
– Ads Removed.
This app has no advertisements
Download Instructions:
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Tags: heroes sim mod, line app mod, line play mod


text:
"There's a possibility that I'll be the first talk show host impeached," he continued. "It's fall here in New York City, and I spent the whole weekend raking my hate mail. It's cold, too—chilly outside, chilly inside my house."Video at the link.
Letterman then mock-started making cracks about Bill Clinton, South Carolina Gov. Mark Sanford and Eliot Spitzer (apparently they all have something in common), stopping himself every time.
"This is only phase one of the scandal," he reminded the audience. "Phase two, next week I go on Oprah and sob."...
"Also," he added, "what can it hurt? Once again I'd like to apologize to the former governor of Alaska. Sarah Palin, I'm terribly, terribly sorry.
October 6, 2009
Letterman's new, improved apology.
58 comments:
- Hoosier Daddy said...
Still wondering why he bothered to marry the broad he was shacking up with for 20 years.
- Lem said...
Mr Letterman I knew Bill Clinton .. Bill Clinton was a friend of mine..
Mr Letterman you are no Bill Clinton. - 10/6/09, 9:23 AM
- bearbee said...
Oprah and rehabilitation...
- Kensington said...
CBS promos for last night's episode were promising a "Sarah Palin Top-10 List!!!1!"
Given that Letterman's intentions re Palin are patently malicious (he's committed to using his show to destroy her politically), I've zero sympathy for whatever his plight is.
He deserves every bit of discomfort and humiliation he's experiencing, and more. - 10/6/09, 9:33 AM
- TRO said...
It's long past time for Dave to retire. He ceased being funny a long time ago and now he won't be able to do half his jokes anymore.
Leno is better still. - 10/6/09, 9:36 AM
- MadisonMan said...
I liked his line that he would have rather spent the weekend on the Appalachian Trail.
There are people who hate Letterman no matter what he does. I doubt he was trying to reach them last night. I thought his words -- what I saw of them on the web today, I could never stay up that late to watch! -- were as pitch perfect as you can get. Imagine if Mark Sanford, or John Edwards, or Larry Craig had actually been honest in their apologies. Or said something that could be construed as honest, as Letterman did. They would be far better off.
A good comic can wring laughs out of human discomfort. Even though it may be helped along by the flashing Applause sign. - 10/6/09, 9:41 AM
- Bissage said...
Looks like Mr. Letterman hired some of Ted Kennedy's joke writers.
- Robin said...
The jokes may be funny, but their very existence highlights his insincerity.
Obviously, this stuff was all written by other people with the dual intentions of distraction from Letterman's behavior and anticipation of criticism, in the hopes of disarming it.
It's all so calculated. - 10/6/09, 9:43 AM
- Paul Chiari said...
Letterman is just another angry, hyprocrital leftist who is now reaping what he has sowed. I would have been immediately terminated from employment for sexual harrassment had I engaged in this type of behavior. Where are the feminists? They seem awfully quiet, and I am sure they would not be if the perpetrator had been a conservative talk radio host. Bad behavior is bad behavior, regardless of political leanings.
- MadisonMan said...
I would have been immediately terminated from employment for sexual harrassment had I engaged in this type of behavior.
This is just a guess. I could be completely wrong.
You don't bring in the millions and millions of dollars to your employer that Letterman does to his employer.
wv: choose. Suddenly I'm getting actual words - 10/6/09, 9:51 AM
- Pogo said...
If Susan Atkins had had better writers, she would have been released, surely.
Better comedy writers would have helped Mao and Stalin, too.
Sure, we had 7 million starve to death last year, but now we have some very plump vultures to eat!
Thank you; I'll be here for life.
Remember to tip your waitress. - 10/6/09, 9:57 AM
- Rialby said...
Here's my take - one time transgression, he gets away with it. Nobody gives a fig.
More and more will come out about what's he been doing for the last 30 years and none of it will be pretty. It won't destroy his career because the Left will protect him but he may lose viewers. - 10/6/09, 9:58 AM
- Hoosier Daddy said...
You don't bring in the millions and millions of dollars to your employer that Letterman does to his employer.
Which just goes to show that if you make the big Benjamins, the rules don't apply to you.
Double so if you're a rich lefty. Not only do you get away with it, you get kudos, applause and probably an award. - 10/6/09, 10:11 AM
- MadisonMan said...
Hoosier, yes, that's the way things work. Doesn't make it legal, but it shouldn't surprise anyone.
Now, if he is a serial harasser, then things will become uncomfortable for CBS. That will be the curious thing to watch for in the next couple months.
And I'll say that I would not want to be a woman working for Worldwide Pants, because the guilt by association is going to be everywhere, and that's the pernicious part about Sexual Harassment in the workplace. - 10/6/09, 10:16 AM
- Pogo said...
If only he had been doing this with drugged 13 year old girls.
There'd be an Emmy for sure. - 10/6/09, 10:17 AM
- AllenS said...
If I want comic relief, I'll turn to garage mahal.
- EDH said...
Guess who: David Letterman, Sarah Palin or Andrew Sullivan?
I have had sex out of love and it's an amazing, wonderful, transformative thing. At its height, it is the most overwhelming thing I have ever experienced. I have also had sex in my life largely as a way to escape this fucking brain in my head, that won't stop constantly analyzing and thinking. I have had sex for these reasons as well - so I can gain a few blissful moments when I do not think at all. The relief of this is indescribable and, for me at least, an element of mental and psychological health.
I recall one marathon twelve-hour session of passion many years ago now. It was only afterwards that I realized I had barely had a single trace of an analytic thought for the longest period I could then remember. I was never happier. As I finally collapsed into my lover's arms with the final orgasm that drained every last drop of desire or need from my body and soul, I understood for the first time why the French call coming "le petit mort". It can be the emptying of self entirely. Which is why sex is so close at times to the presence of the divine, and reflects and incarnates God in ways few other things can so easily. We are more animal and more divine in sex than in any other activity.
The ordeal of consciousness is at times oppressive. To leave that consciousness and yet stay so vividly alive is one of sex's great wonders. Love is deeper than that; friendship is deeper still. But I know nothing that God has given us - save psilocybin - that gives us this divine, if fleeting, parole from a vale of tears. - 10/6/09, 10:18 AM
- Michael Hasenstab said...
I don't know which is worse - his lameness of the insincere apology made to his wife.
Either way, the guy is a jerk.
And soon will be a jerk with way fewer assets. - 10/6/09, 10:24 AM
- garage mahal said...
I have also had sex in my life largely as a way to escape this fucking brain in my head, that won't stop constantly analyzing and thinking.
Definitely not Palin. - 10/6/09, 10:24 AM
- Pogo said...
"The ordeal of consciousness is at times oppressive."
Definitely Sullivan.
He's had trouble with consciousness for several years now, if one goes by his writing. - 10/6/09, 10:29 AM
- MadisonMan said...
Memo to Sullivan: TMI!
No one wants to read about your sex life. - 10/6/09, 10:35 AM
- Bissage said...
- This comment has been removed by the author.
- Robin said...
Poor Andrew. The massive size of his amazing intellect requires him to have lots of meaningless sex.
- madawaskan said...
Drudge is reporting that he had a secret bedroom above The Ed Sullivan Theater.
No way! That's like Walt Disney's apartment in the Magic Castle.
[so he could schtoop Snow White!] - 10/6/09, 10:45 AM
- madawaskan said...
Spell check tells me I'm spelling -schtoop- correctly!?
Good ta go! - 10/6/09, 10:47 AM
- shoutingthomas said...
What an asshole!
I never watch him. Why bother?
Seems the liberal line on sex and harassment has boiled down to this:
Liberals don't claim to have any ethics. Thus, ethics aren't demanded of liberals. Conservatives claim to have ethics. Therefore, they are the worst type of scum... hypocrites. - 10/6/09, 10:49 AM
- Oligonicella said...
garage mahal --
"Definitely not Palin."
Correct. Not only would she not curse for public record, but she enjoys her thinking, which Sullivan apparently doesn't. - 10/6/09, 10:51 AM
- Meade said...
Trick question, right?
The correct answer is - Penelope Trunk. - 10/6/09, 10:51 AM
- Darcy said...
I noticed that right off too, Michael H. How classy of him to make his wife part of his faux embarrassed jokes. He doesn't care.
What a pig. - 10/6/09, 10:53 AM
- madawaskan said...
Again Sully is confused when he heard-
"le petit mort" he didn't realize they were talking about his... - 10/6/09, 10:56 AM
- Hoosier Daddy said...
There is an art to being a smartass and Letterman is a failure.
For example, I was playing Rock Band with Hoosier Daughter over the weekend and she is quite talented at the guitar it must be said. Needless to say I had to demonstrate my prowess on the drums and after a blistering set of Don't Fear the Reaper on medium difficulty I scored a respectable 95%. When I looked at Hoosier Daughter expectantly for praise all she had to say was. "You need more cowbell."
That's being a smartass. - 10/6/09, 11:00 AM
- William said...
Letterman makes eighteen million a year for telling clever jokes in a charming, self-deprecatory way. He's very good at it, and it is not surprising that he should make a graceful apology. For just that reason, his apology should be judged not as an apology but as a performance. As a performance, it was successful; as a demonstration of character, it was a successful imitation of a demonstration of character......Letterman is funnier than Conan and less funny than Leno. That is what comedians are paid for: their jokes. Anyone who thinks the ability to tell funny jokes is indicative of character or political wisdom is crazy. It's not even a chance correlation; it's a negative correlation.....Life is not a morality play. That's not the part that hurts. The hard part is that the wicked write the plays, win the awards, and host the show. Letterman will get monster ratings. This will not be viewed as his failing but as a travail that he has overcome.
- William said...
The love affair that Andrew Sullivan is having with his penis is less than sublime and beyond parody.
- Jason (the commenter) said...
Is he making fun of our obsession with apologies?
- garage mahal said...
Not only would she not curse for public record, but she enjoys her thinking,.
Such as it is. If it would fool Todd, that's good enough for the rest of us! - 10/6/09, 12:03 PM
- Slow Joe said...
I guess it's a smart move to keep pushing jokes about this issue in order to get lots of ratings.
I was surprised madison man claimed this was a sincere apology, though. It was self serving in the extreme, impersonal, and just plain fake. Mark Sanford's pathetic explanation that he was actually in love came across as the opposite: self damaging, honest, and real.
A good apology is not going to please random third parties.
Letterman is not funny... he's a safe harbor for those pathetic few who cannot stand to hear jokes about Obama and insist on repeated jokes against republicans. It's for weak, weak people with no sense of humor. A waste of time. Letterman is a slimeball, but we knew that years ago.
Once again, the next president makes all the right people furious. Letterman still has failed to explain why he's so damn angry with Sarah Palin and her kids. - 10/6/09, 12:44 PM
- Slow Joe said...
'making fun of our obsession with apologies'
It's easy to pretend there is nothing sacred and nothing serious in the world. Especially when you use your power over young lady's careers to get into their pants.
Sarah Palin asked for an apology from a man who jokes about raping her 14 year old daughter. That's not unreasonable. Or obsession. That was a perfectly normal and mild mannered thing to do. Letterman's obsession with Palin is not normal, not that I care. He has dramatically increased the likelihood that Palin will be president.
Nothing worse than trying to bully someone who wins the fight. - 10/6/09, 12:47 PM
- Ken Begg said...
I have also had sex in my life largely as a way to escape this fucking brain in my head, that won't stop constantly analyzing and thinking.
Definitely not Palin.
Yes, because Andrew Sullivan is smarter than Sarah Palin. Right. - 10/6/09, 1:33 PM
- Kev said...
(the other kev)
The only apology that counts is learning from your mistakes. I don't see that here.
I'm with other folks wondering if there's another shoe waiting to drop. What we've heard about so far doesn't seem to be worth 2 million. - 10/6/09, 1:33 PM
- David said...
Sullivan, shorter version (pun intended): "Say hello to my leetle friend . . . . "
- Freeman Hunt said...
Wow! The scandal made him funnier!
Chilly? Yow. I bet. - 10/6/09, 2:24 PM
- chickenlittle said...
LOL'n @ Meade's 10:51
- Freeman Hunt said...
Maybe Sullivan wrote all of his Palin material while having sex. If sex allows him to escape his brain, that would explain a lot.
- Freeman Hunt said...
If he were standing on a #cowmat while doing that, he would have had the necessary traction to stand steadily and type.
- chickenlittle said...
If he were standing on a #cowmat while doing that, he would have had the necessary traction to stand steadily and type.
Sullivan would have turned his #cowmat into a big giant slip 'n' slide. - 10/6/09, 2:52 PM
- rhhardin said...
Those were good jokes.
``Did your weekend just fly by?''
They're angry woman jokes, guy stuff. Shared experiences alluded to. - 10/6/09, 3:39 PM
- Pogo said...
Does Letterman have any good Roman Polanski jokes?
Does Roman Polanski have any good Letterman jokes? - 10/6/09, 4:23 PM
- Jeremy said...
Hoosier - "Still wondering why he bothered to marry the broad he was shacking up with for 20 years."
I see those knuckles are still dragging.
Who the hell still uses terms like "broad" and "shacking up?"
Come out of the corn field, Hoosier...life is passing you by. - 10/6/09, 4:45 PM
- Jeremy said...
Slow (and I do mean s-l-o-w) Joe - "
Sarah Palin asked for an apology from a man who jokes about raping her 14 year old daughter."
Except he wasn't referring to the 14 years old.
Maybe if you were to actually read something before posting the standard drivel? - 10/6/09, 4:47 PM
- Jeremy said...
Hoosier Daddy said..."There is an art to being a smartass and Letterman is a failure."
Yeah, the guy is REALLY struggling to find a niche.
If only he could find a job as, oh, maybe a smart ass talk show host...that pays...millions.
Duh. - 10/6/09, 4:50 PM
- Pogo said...
3 posts to skip.
Thanks, J-man. - 10/6/09, 5:31 PM
- montana urban legend said...
- This comment has been removed by the author.
- chickenlittle said...
Good call MUL! That comment sucked.
- montana urban legend said...
But apparently your willingness to imitate Beavis and Butthead's take on the Letterman-obsessed doesn't!
- Gabriel Hanna said...
Except he wasn't referring to the 14 years old.
Bristol wasn't at the game, Willow was.
Letterman DID refer to her, though he didn't intend to.
Nice try, jackass. Read something before you post the usual drivel. - 10/6/09, 8:05 PM
- MadisonMan said...
I was surprised madison man claimed this was a sincere apology, though
Where did I say that? - 10/6/09, 8:17 PM
- knox said...
A good comic can wring laughs out of human discomfort. Even though it may be helped along by the flashing Applause sign.
I really could care less about Letterman's affairs or whatever. But that first confession, delivered in the same snarky, dissembling manner he delivers EVERY joke, disgusted me. - 10/6/09, 11:18 PM
- kentuckyliz said...
Has Letterman promised to keep his Worldwide Pants zipped?


text:
Bioequivalence Study of Lisinopril Tablets 40 mg Under Fasting Condition
- Full Text View
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- How to Read a Study Record
Condition | Intervention | Phase |
Fasting |
Drug: Lisinopril Tablets 40 mg Drug: Lisinopril |
Phase 1 |
Study Type: | Interventional |
Study Design: | Allocation: Randomized Intervention Model: Crossover Assignment Masking: Open Label Primary Purpose: Treatment |
Official Title: | A Randomized, Balanced, Open Label, Two Treatment, Two Period, Two Sequence, Single Dose, Crossover, Bioequivalence Study of Lisinopril Tablets 40 mg With Zestril® (Lisinopril) 40 mg Tablets in Normal, Healthy, Adult, Male and Female Human Subjects Under Fasting Conditions. |
- Cmax [ Time Frame: 2 months ]Sampling Hours: Pre-dose and at 1.00, 2.00, 3.00, 4.00, 5.00, 6.00, 6.25, 6.50, 6.75, 7.00, 7.25, 7.50, 7.75, 8.00, 8.50, 9.00, 10.00, 12.00, 16.00, 24.00, 48.00 and 72.00 hours post dose
- AUC [ Time Frame: 2 months ]Sampling Hours: Pre-dose and at 1.00, 2.00, 3.00, 4.00, 5.00, 6.00, 6.25, 6.50, 6.75, 7.00, 7.25, 7.50, 7.75, 8.00, 8.50, 9.00, 10.00, 12.00, 16.00, 24.00, 48.00 and 72.00 hours post dose
Enrollment: | 40 |
Study Start Date: | June 2012 |
Study Completion Date: | August 2012 |
Primary Completion Date: | August 2012 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
Experimental: Lisinopril Tablets 40 mg
Lisinopril Tablets 40 mg of Ipca Laboratories Limited, India
Drug: Lisinopril Tablets 40 mg
40 mg tablet once a day
Other Name: Test Product
Active Comparator: Zestril® (Lisinopril) 40 mg Tablets
Zestril® (Lisinopril) 40 mg Tablets of AstraZeneca Pharmaceuticals LP USA
Drug: Lisinopril
40 mg tablet once a day
Other Name: Zestril® (Lisinopril) 40 mg Tablets
Detailed Description:
Objective of this pivotal study was to assess the bioequivalence between Test Product: Lisinopril Tablets 40 mg of Ipca Laboratories Limited, India and the corresponding Reference Product: Zestril® (Lisinopril) 40 mg Tablets of AstraZeneca Pharmaceuticals LP USA, under fasting condition in normal, healthy, adult, male and female human subjects in a randomized crossover study.
The study was conducted with 40 healthy adult subjects. In each study period, a single 40 mg dose of either test or reference was administered to the subjects as per the randomization schedule in each study period with about 240 mL of water at ambient temperature in sitting position.
The duration of the clinical phase was approximately 19 days including washout period of 15 days between administrations of study drug in each study period.
Ages Eligible for Study: | 18 Years to 45 Years (Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- Male and non pregnant female human subjects, age in the range of 18 - 45 years.
- Body weight within ± 15% of ideal weight as related to height and body frame according to Life Insurance Corporation (LIC) Chart.
- Subjects with normal findings as determined by baseline history, physical examination and vital sign examination (blood pressure, pulse rate, respiration rate and axillary temperature).
- Subjects with clinically acceptable findings as determined by haemogram, biochemistry, urinalysis and 12 lead ECG.
- Willingness to follow the protocol requirements especially abstaining from xanthine containing food or beverages (chocolates, tea, coffee or cola drinks) or grapefruit juice, any alcoholic products, the use of cigarettes and tobacco products for 48 hours prior to dosing until after the last blood sample collection in each study period and adherence to food, fluid and posture restrictions.
- No history of significant alcoholism.
- No history of drug abuse (benzodiazepines and barbiturates) for the last one month and other illegal drugs for the last 6 months.
- Non-smokers were included.
Exclusion Criteria:
- Known history of hypersensitivity to Lisinopril or related drugs.
- Requiring medication for any ailment having enzyme-modifying activity in the previous 28 days, prior to dosing day.
- Subjects who have taken prescription medications or over-the-counter products (including vitamins and minerals) within 14 days prior to administration of Investigational Product.
- Any medical or surgical conditions, which might significantly interfere with the functioning of gastrointestinal tract, blood-forming organs etc.
- History of cardiovascular, renal, hepatic, ophthalmic, pulmonary, neurological, metabolic, haematological, gastrointestinal, endocrine, immunological or psychiatric diseases.
- Participation in a clinical drug study or bioequivalence study 90 days prior to present study.
- History of malignancy or other serious diseases.
- Blood donation 90 days prior to the commencement of the study.
- Subjects with positive HIV tests, HBsAg or Hepatitis-C tests.
- Found positive in breath alcohol test.
- Found positive in urine test for drug abuse.
- History of problem in swallowing.
- Any contraindication to blood sampling.
- Found positive serum Beta- hCG (Human Chorionic Gonadotropin) test.
- Lactating women (currently breast feeding).
- Female subjects not confirming to using birth control measures, from the date of screening until the completion of the study. Abstinence, barrier methods (condom, diaphragm, etc.) were acceptable. Use of hormonal contraceptives either oral or implants.
- Female subjects whose menstruation cycle coincided with the study periods.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01735318
India | |
Accutest Research Lab (I) Pvt. Ltd. | |
Navi-Mumbai, Maharashtra, India |
Principal Investigator: | Dr. Suhas Khandave, M.D. | Accutest Research Lab (I) Pvt. Ltd. |
Responsible Party: | IPCA Laboratories Ltd. |
ClinicalTrials.gov Identifier: | NCT01735318 History of Changes |
Other Study ID Numbers: |
Ipca/ARL-10/384 |
Study First Received: | November 5, 2012 |
Last Updated: | November 30, 2012 |
Additional relevant MeSH terms:
Lisinopril Angiotensin-Converting Enzyme Inhibitors Protease Inhibitors Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action |
Antihypertensive Agents Cardiotonic Agents Protective Agents Physiological Effects of Drugs |
ClinicalTrials.gov processed this record on March 29, 2017