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The typical first-time mother takes 6 1/2 hours to give birth these days. Her counterpart 50 years ago labored for barely four hours.
That's the striking conclusion of a new federal study that compared nearly 140,000 births from two time periods.
One big implication: Today's obstetricians may be rushing to do cesarean sections too soon because they're using an out-of-date yardstick for how long a "normal" labor should take.
"That's absolutely correct," says Dr. Ware Branch of Intermountain Healthcare in Salt Lake City, a study author. Lead author Dr. Katherine Laughon of the National Institute of Child Health and Human Development agrees.
The definition of a "normal" labor — the range of times when a woman in labor reaches certain milestones — was laid down in the 1950s. Contemporary obstetricians still use that "labor curve."
"The past definitions of 'normal' labor have been used to draw the line as to when it's time to intervene with a cesarean delivery," Branch said during a telephone conference with reporters. "But what we've shown is that labor is actually longer … than it was 50 years ago. That certainly calls for a reassessment of when one should draw the line for cesarean delivery."
Last year Branch and his colleagues at Intermountain Healthcare calculated that the U.S. could save $3.5 billion by lowering the national cesarean delivery rate from 32 percent to 21 percent, which is the C-section rate in the Utah hospital system. A cesarean birth costs nearly $17,000, compared with $9,400 for a vaginal delivery.
The reasons for today's much longer labors aren't entirely clear. They may have something to do with differences in today's mothers compared with their grandmothers. For instance, first-time mothers are about four years older on average, they have higher body mass, and they're more racially diverse.
Today's babies are also bigger — for instance, first-borns are 4 ounces heavier today than the 1960s crop.
But study authors say the most important causes for longer labors are what obstetricians do, not how their patients have changed. Even after statistically adjusting for differences in maternal and newborn characteristics, modern labors are still substantially longer.
Laughon says part of the reason is a jump in the use of epidural anesthesia during labor.
"That is known to prolong labor by approximately 40 to 90 minutes," Laughon says. "Of course, it's very accepted practice to help improve pain control during labor."
Branch points out that up to 85 percent of contemporary laboring mothers get epidurals. "Once that's in place, they're in bed," he says. "In the late '50s and early '60s, how much did people get up out of bed during labor and walk around?"
Another big change is that many more women have induced labors these days. That is, they're not permitted to go into labor spontaneously. One in three women had spontaneous labor, among women giving birth between 2002 and 2008.
Women today are 19 percent more likely to get a drug called oxytocin, which increases the strength of uterine contractions. But this should shorten labors, so the study authors note that "if women were allowed to progress in natural labor without oxytocin, the stages of labor could be even longer with the same odds of achieving vaginal delivery."
Laughon and Branch acknowledge their results may be controversial among some obstetricians — those who view it as an attack on epidural anesthesia, for instance. "Some skeptics are going to say, 'Gee, you really don't know the details about these two groups 50 years apart to be able to compare them fairly,' " Branch says. "That's a legitimate criticism."
But the "plain and simple fact," they say, is that giving birth takes longer today. They say all they're suggesting is that today's routine practices "may need to be thoughtfully reconsidered."


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Old Fashion Egg Custard
Nutritional Info
- Servings Per Recipe: 6
- Amount Per Serving
- Calories: 87.9
- Total Fat: 1.8 g
- Cholesterol: 71.8 mg
- Sodium: 159.1 mg
- Total Carbs: 12.8 g
- Dietary Fiber: 0.2 g
- Protein: 4.8 g
View full nutritional breakdown of Old Fashion Egg Custard calories by ingredient
Submitted by: MAMAMIAOF3BOYS
Easy Breezy Custard! Easy Breezy Custard!Number of Servings: 6
2 eggs
2 cups of warm milk
1/4 tsp salt
1 tsp vanilla
1/4 cup sugar
1 tsp of cinnamon
In an 8x8 baking dish, beat the 2 eggs. Add sugar, salt, and vanilla, and whisk together. Warm milk in the microwave, then slowly add to the egg mixture. Whisk well. Sprinkle top with cinnamon and bake at 350 degrees for about 35 minutes or until done in center.
Number of Servings: 6
Recipe submitted by SparkPeople user MAMAMIAOF3BOYS.
Number of Servings: 6
Recipe submitted by SparkPeople user MAMAMIAOF3BOYS.

subset: commoncrawl


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Ports were closed, school classes were suspended and hundreds of people were evacuated along Mexico's southern Pacific coast on Monday as a major hurricane loomed over a region still recovering from record flooding a few weeks ago.
Raymond, a category three hurricane, was stationary with winds blowing up to 120 miles per hour (193 kph) on Monday, around 100 miles (161 km) offshore. Forecasters said it could head west as the week progresses without hitting land.
However, the hurricane was already dumping steady rain on coastal areas including Acapulco, where storms wrecked homes, roads and cars and stranded tourists last month.
By early afternoon, parts of the city were drenched in water, its port was closed and many roads were washed out.
The Miami-based U.S. National Hurricane Center said Raymond,
the first major hurricane of the Eastern Pacific season, was likely to strengthen over the next day or so and could churn closer to the coast later on Monday and Tuesday.
Mexico has no major oil installations in the area threatened by Raymond, which has swirled around 160 miles (257 km) west-southwest of Acapulco since Sunday night. The hurricane was about 105 miles (169 km) south-southwest of the city of Zihuatanejo at 3:00 p.m. (2000 GMT).
Mexico's Gulf Coast is also facing heavy rains due to the advance of a cold front from the north, which has halted Raymond's progress in the south, the government said.
"If (Raymond) carries on moving at this speed and the cold front keeps holding it, we'll have permanent rain for the next 72 hours," Luis Felipe Puente, head of Mexico's national emergency services, told a news conference in Acapulco.
Hurricane alerts are in place from Acapulco, which lies in Guerrero state, to Lazaro Cardenas in Michoacan state. More than 800 people have been evacuated from the northwestern fringe of Guerrero down to Acapulco, emergency services said.
Anticipating heavy rains, schools closed in Acapulco, in Lazaro Cardenas and other parts of the southwestern coast. The port in Lazaro Cardenas was also closed, the government said.
Rainfall during the next few days could trigger life-threatening flash floods and mud slides, the NHC said.
Angel Aguirre, the governor of Guerrero, urged people to leave areas at high risk of flooding, and Michoacan's government said all maritime activity and road travel should be avoided.
Mexico suffered its worst floods on record in mid-September when tropical storms Manuel and Ingrid converged from the Pacific and the Gulf of Mexico, killing more than 150 people and causing damage estimated at around $6 billion.
Some 5,700 people are still living in shelters in Acapulco due to the impact of those storms, the Guerrero government said.
Acapulco, whose economy relies heavily on tourism, saw hotel occupancy rates plunge to record lows after the storms, which also knocked out the city's airport for a time. As of Monday afternoon, Acapulco's airport was still open.
Up to 15 cm (6 inches) of rain could hit the coast, Mexico's national meteorological service forecast.
The flooding, mudslides and displacement of thousands of people caused by the recent storms have heightened the risk of waterborne illness in Mexico. The country has recorded its first local transmission of cholera in just over a decade.


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Edit Full Name: Eugene Landrum 1 Birth: 06 Feb 1891 1 Death: Jul 1967 1 Residence: Last Residence: Springfield, IL 1
Looking for more information about Eugene Landrum? Search through millions of records to find out more. Find more records
Anyone can contribute to this page. Please sign in or sign up—it's free. Source: Social Security Death Index Created: 03 Sep 2008 Modified: 07 Oct 2013 Page Views: 18 total (0 this week)
annecamillelandrum260 GrandfatherAdded by annecamillelandrum260 17 Mar 2013 annecamillelandrum260 Added by annecamillelandrum260 04 Feb 2013


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Auvio In Ear Armature Headphones
" I was trying to be generous with this review, I had these for fewer than two hours because of the comfort, They ACTUALLY cut up my ear canals, there is no exaggeration, my ears bled, and I've never been a fan of foam tips. Foam tips get ripped up, and really feel insecure in my ears, plus the plastic tube can become exposed and creates a level of discomfort greater than that of the silicon..." --ffdpmaggot
Auvio Pearl Buds
Headphones deliver a personized sound experience. They deliver high-quality stereo sound with a frequency response of 22Hz-19kHz, and feature an iPhoneTM compatible 24k gold-plated 1/8" connector, so they're perfect for almost any personal media player. The noise-reduction silicone tips reduce surrounding noise for better sound quality, and three sets are included so they can...
HiSoundAudio BA100
" So after a day of somewhat abusive run in (free and impatient) and tip rolling, I can say these easily play in a realm at or above their $100 price point. The stock tips are fine and Grado tips also work well but try a few doubles on them all the way to the base and you may get really great results. The stock tips are short and I prefer those up near the tip, the Grado/Orto tips..." --goodvibes
HiSoundAudio Crystal
"Introducing HiSound Audio's Crystal IEMs After reviewing HSA's E212 and PAA-1Pro recently, Jack approached me and asked if I'd like a review sample of the Crystal (IEM) and Living (Earbuds). I jumped at the chance, and after paying for the freight - they duly arrived a couple of weeks ago. I've listed price at the RRP of ~ USD $69 – this is not what I paid for them..." --Brooko
HiSoundAudio E212
"I am a Grado fan. More precisely, I am a Grado modder. Everything I listen to is tinkered with, and woodied….Needless to say, I favor a bright sound signature, open-backs and am not very into IEMs. For all of my listening I use my FiiO X5 on low gain, loaded with 16/44 FLAC files. IEMs are a necessary evil in an occasionally noisy world, but given I have oddly shaped ear canals (thanks to a..." --fleasbaby
HiSoundAudio E300
"REVIEW: HisoundAudio E300 Specs: Type: Dynamic Size of the driver: Φ 7mm Impedance: 16 Ω Sensitivity: 100 db Maximum SPL: 125db(1khz,1 Vrms) Frequency response: 20-20000 Hz The length of the cable: 124 cm Cable wire :High quality OFC Price: U$D 19.99 Accessories: As mine are just a sample, I didn't receive any extra accessories, but according..." --Zelda
HiSoundAudio Golden Crystal
"Hisoundaudio Golden Crystal First I'd like to thank Jack at Hisoundaudio for giving me the opportunity to purchase the Golden Crystals, or GC as I'll reference them, as they are not yet available from any US dealer. Meet the super tiny Golden Crystals. They are the smallest dynamic driver on the planet (I think the Monster Tributes are 5mm as well, if..." --shotgunshane
Hisoundaudio HA-2
" Preamble: HiSoundAudio (http://www.hisoundaudio.com/en/index.asp, not up to date) is a Chinese audio company, known for their in-ears and audio players. Besides their new DAP, they are also about to come out with a new in-ear model. Having talked to Jack from HiSoundAudio, he said that they are extremely confident about their upcoming single-BA in-ear which is..." --HiFiChris
Hisoundaudio HSA-AD1 in-ear dual hybrid in-ear monitor with microphone and remote
" At the time of the review, the Hisoundaudio HSA-AD1 was was on sale on Penon Audio's website. Here is a link to their listing of the product: http://penonaudio.com/Hisoundaudio-HSA-AD1 Introduction Here we go, another hybrid in-ear hitting the market! Have you noticed a theme here? It seems like all the sudden there's an explosion of these things, and truth be told..." --Hisoundfi
HiSoundAudio Living
"Foreword: I'm a production manager, but mainly focus on live sound engineering and lighting. I install and tune P.A equipment, and mix live acts in: - live venues, - concert halls, - bars, and - nightclubs. I've taken a huge liking to headphones - IEMs in particular. I like the idea of having my own personal PA system that I can take with me anywhere. With Rockbox being in such..." --White Lotus


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Magnetite reducing bacteriaModerator: BioTeam
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Magnetite reducing bacteriaHello
I'm interested in microorganisms that are capable of reducing magnetite (Fe3O4) or other iron oxide. I found this rather old article : http://www.ncbi.nlm.nih.gov/pubmed/11539843 This article centers around the reduction of magnetite by Shewanella, when coupled to oxidation of organic compounds. However, despite my efforts to find additional information about the process, I could not find anything useful. I'm especially interested in studies of the molecular or enzymatic mechanism of reduction. I would appreciate any hints or references, if anyone here knows anything about this matter. If this is not the right place to ask, please direct me to a more apropriate forum or group. Thanks a lot !
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The restaurant that changed the way we dine—
August/September 1980 | Volume 31, Issue 5
When Charles Dickens first came to the United States in 1842, he did not like our clothes, our speech, or our manners. But he reserved perhaps his deepest scorn for our dining habits. First, there was the custom in public places of summoning diners to the table by thwacking an "awful gong which shakes the very window frames as it reverberates through the house and horribly disturbs nervous Foreigners." Then there was American food itself, which Dickens dismissed as "piles of indigestible matter." It did not seem to make any difference where a foreigner dined in America. Be it in an inexpensive boardinghouse where, as one observer pointed out, "the Venetian blinds are kept scrupulously closed, for the double purpose of excluding flies and preventing too close a scrutiny of the upholstery" or in more well-appointed hostelries where men sat about "smoking seegars, their feet up on the white marble balustrade and spitting," the social graces of the New World were not highly esteemed by visitors from the Old.
Continental travelers were particularly distressed to find no establishment where one could buy a decent meal. Restaurants had been a popular idea on the Continent ever since 1782, when chef Beauvillier first opened his doors in Paris. Frenchmen had a score of "restoratives" to indulge themselves in, from the haute cuisine of the Quadron Bleu to the raffish Tortoni's, w. where Parisian bloods could have a duelist's breakfast—patés, game birds, fish, broiled kidneys, and champagne—before going out to shoot each other.
A half-century later, however, there was still not a single restaurant in New York City worthy of the name. It was all but impossible to get a hot meal during the middle of the day, and businessmen were accustomed to stuffing cold sandwiches in their pockets before going to work in the morning. Professionally prepared meals, when they existed at all, tended to be either dreary boardinghouse fare or some startling local creation. At the Bank Coffee House, for instance, one of the specialities was a whole cooked bear wheeled into the dining room steaming hot and served standing up.
However, by the time Dickens returned for his second and last visit in 1868, an immense social and culinary revolution had taken place in America. The banquet held in Dickens' honor at Delmonico's Restaurant on Fourteenth Street was the equal of anything in Europe. Oysters, two soups, a delicate timbale, salmon and bass, filet mignon, stuffed lamb, braised lettuce, and grilled tomatoes served merely as opening courses. The dinner then proceeded on through another thirty dishes representing the highest accomplishments in international cuisine.
Tired and ill, Dickens originally had hoped to beg off from the affair, but the dinner acted as a tonic for the novelist, and near its close he was moved to speak. He referred to the unpleasant remarks about America he had made on his previous journey, and noted that this time, "I have been received with unsurpassable politeness, delicacy, sweet temper, hospitality [and] consideration." Perhaps warmed by the vintage wines, he grew more expansive and added: "This testimony … I shall cause to be republished as an appendix to every copy of those two books of mine in which I have referred to America. And this I will do and cause to be done, not in mere love and thankfulness, but because I regard it as an act of plain justice and honor."
Dickens' enthusiasm suggested something of the importance of the House of Delmonico. In a generation, a prolific family of Swiss restaurateurs had almost singlehandedly snatched the napkin from under the chin of American diners, taught them to sit up properly, use the correct salad fork, and order in French.
First and foremost, Delmonico's—in its ninety-six years of ascendancy there were eleven establishments in New York bearing the name of Delmonico, four of them operating concurrently—was the premier restaurant in America. Occasionally a famous guest would complain about the prices. William Makepeace Thackeray was astonished when his check for a small dinner came to four pounds per person, and warned his friend the poet Bayard Taylor, "Don't, don't give a dinner at Delmonico's. I did it yesterday and it is a sin to spend so much money on your belly."
Nevertheless, Thackeray returned several times. Delmonico's had no competition.
Abraham Lincoln, after dining there during the Civil War, called Lorenzo Delmonico to his table and told the restaurateur, "In Washington, where I live, there are many mansions, but no cooks like yours."
So lustrous was the restaurant's image that in the 1880's an English magazine informed its readers that the two most remarkable sights in America were "Delmonico's and Yosemite Valley." At about the same time Harper's Weekly took a long and satisfied look at the emergence of the social and culinary niceties in America, and noted, "When we compare the commensalities of our country before the Delmonico period … with our condition in respect of dinner now, and think how large a share of the difference is due to Delmonico's, we shall not think it extravagant to call Delmonico's an agency of civilization."


text:
Starlight Serenade
Ferndale Dance Academy celebrates Its 10th anniversary! This year the Ferndale Dance Academy presents, Starlight Serenade, an original production written and narrated by Laura and Michael East. The story takes place on the back lot of a Hollywood movie studio and follows a girl named Judy as she endeavors to get a screen test to play Dorothy in the Wizard of Oz. Along the way she meets a screenwriter with writer's block, a jaded movie star, and an actor from the silent era who is terrified to speak on film. This lively and theatrical production is approximately 1.5 hours in length and is great entertainment for all ages. |
- $15 / $12 kids 12 and under


text: BobbitIf it isn't weel bobbit we'll bob it again. If it is not done well enough, we will try again. To bob is to dance, and literally the proverb means, "If it is not well danced, we will dance over again." Source: Dictionary of Phrase and Fable, E. Cobham Brewer, 1894


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Sage Advice: SNL, logistics, and a wet Italian cruise liner
Humor aside, NBC's Saturday Night Live (SNL), logistics, and a submerged Italian cruise ship have a lot in common.
in the News
State of Logistics 2016: Pursue mutual benefit Challenges remain in store for shippers, says FTR SCI report Florida East Coast Railway to be acquired by Grupo Mexico Cat Lift Trucks awards $5,000 scholarship to high school student Survey: CFOs setting more strategy, crunching fewer numbers More NewsHumor aside, NBC's Saturday Night Live (SNL), logistics, and a submerged Italian cruise ship have a lot in common.
I recently watched a promo for SNL where the guest host was talking about the skit rehearsals and what a daunting task it is when things are changed, dropped, or added at the very last minute. The host said he did not know if he would be ready. To this, an SNL regular said: "The show doesn't go on because you're ready, it goes on because it's 11:30 p.m. on Saturday night." In other words: Ready or not, it's show time.
The same, unfortunately, held true for Captain Schettino and the crew of his ship Costa Concordia—and so too is the reality of logistics and supply chain management.
The simple question is: Will you be ready? However, the better questions to ask are: Does your team consistently train, and if so do you only train on transactional activities like tendering freight? Or, do you train only after an audit finds shortcomings?
It's not that we were never exposed to the concept of training or rehearsing. Looking back on our lives, we were taught to practice everything from our first grade play to fire drills, and from academic exercises like multiplication tables and pre-SAT tests to group activities like musicals and sports.
So, what happened to all of those training and rehearsing skills? Well, we know it wasn't part of the culture on the Costa Concordia's command staff. Is rehearsing and training only for actors, athletes, students, singers, pilots, NASA, and the military? Sometimes, I think that logistics professionals have become intellectually arrogant and feel that they are above training and rehearsing. Hopefully your company's culture supports non-technical training and rehearsing and they don't fall victim to the infamous ROI.
Most companies mainly focus their proactive training on transactional skills, safety, information systems, and human resource compliance; while rehearsing seems to be isolated to fire drills—and even then, getting some to comply is a challenge.
The reactional training is often based on unfortunate events and audits. As a result of the shipwreck off of Giglio Island, for example, new training procedures for pre-departure rehearsals will likely be implemented. What a disastrous and expensive way to introduce a seemingly logical process change.
So, do you and your employees know what the processes and rules are, where they are housed, and how they are accessed? Do you ask your team if they're following the processes/protocols and accept a yes or no? If an audit tomorrow finds a variant, will you be surprised and say: "I thought we changed that."
A good example of how things evolve is singing. You think after a while that you know the song, but over time you gradually begin to sing your version of the song. You or your colleagues may have rationalized that the song sounds better without regard for the consequences of those changes.
Your guiding principles must be embedded in your program and followed by everyone. Has your team slowly hijacked your programs, commitments, and processes? Teams that have chosen to micromanage your programs into something that they like just a little bit better are placing the integrity or reputation of your program with your carriers and customers at risk.
Have the courage to require your team to test and practice in spite of leadership concerns for ROI. Avoid the temptation of the adrenaline rush that comes from operating too close to the rocks.
It's show time. Are you ready?
About the Author
John A. Gentle John A. Gentle is president of John A. Gentle & Associates, LLC, a logistics consulting firm specializing in contract/relationship management and regulatory compliance for shippers, carriers, brokers, and distribution centers. A recipient of several industry awards, he has more than 35 years of experience in transportation and logistics management. He can be reached at [email protected]Subscribe to Logistics Management Magazine!
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5 Supply Chain Trends Happening Now 2017 Warehouse/DC Equipment Survey: Investment up as service pressures rise View More From this Issue


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I'm a total nut when it comes to bunny-related accessories. They're perfect because they fulfill my childhood desire for a bunny and my very adult desire to not clean up after one. Designed by Tina Frey, these little rabbit-eared pedestals and domes would be adorable for a party or baby shower. They've got that whimsical, child-like feel I like in tabletop design and are even dishwasher safe. Click here to check them out in more detail and shop ($176) online. xo, grace
They're so cute! and you're right, such a great idea for kid's parties!
These are fantastic!! I love all things bunny
Ever since I got my bunny Stella, I'm on a search for all things bunny! Love the ears as handles on these dishes:)
This is sooooooooooooooooooooo cute!!!!! I want one NOW!
Thanks for sharing ! -
oh man, WHAT is it about the bunnies? I have developed this crazy love for bunnies. Glad to hear I am not the only one. I love these pieces from Tina Frey…they will be going on my pinterest bunny board asap.
Love these! They'd look so cute with some bright cupcakes on top :)
You could never say no to bunny ears :) I have to agree it would be great for a kids party.
How cute are the bunny ears! For some reason I keep imagining all kinds of miniature woodland animals hiding in the dome.
so pretty! I love them!
that's so cuuuuuuuuuuute
this is going on my pinterest board! -
these are adorable and surprisingly grown up. i have a pet rabbit though and have to avoid most rabbit-related products because of the "crazy bunny lady" effect. also a side note, rabbits are really easy to care for and not messy at all. ms. jackson however would surely not approve ;)
You'd be surprised at how trainable and clean bunnies actually are, Grace. I had a house rabbit for a little over a year. I found him in the middle of the road one rainy night, picked him up and took him home. He slept in a box that we decorated as his 'Rabbitat' and successfully trained him to go in a litter box. He integrated into the family with our two cats. Just sayin'
Ditto on all the other bunny lovers' comments out there – my two are my first pets and I think they are fantastic! And if you need to cut back on super cute bunny themed accessories… Don't ever go to Japan.


text: NASDAQ Plans to Compensate Facebook IPO LosersJamie Condliffe6/06/12 4:41amFiled to: Facebookfacebook iponasdaq14EditPromoteShare to KinjaToggle Conversation toolsGo to permalink After openly admitting that they screwed up over Facebook's IPO, NASDAQ is now planning to compensate those who made a loss when their systems failed to allow trades to take place. The losses—a result of a 30 minute delay in trading which left brokers with millions of shares' worth of unconfirmed trades—total over an estimated $100 million, according to the Wall Street Journal. Advertisement Advertisement In the first instance, NASDAQ is planning to pay out more than $13.7 million in compensation. The Wall Street Journal reports that the form of the pay-out is so far unconfirmed, though it may come as discounted trading fees for the financial firms that lost money.In fact, current rules state that NASDAQ is limited to paying out just $3 million a month to brokers and traders that suffered losses—so it looks like the process will be long and slow.Facebook's stock continues to sink, dropping to $25.87 on Tuesday 5th. [Wall Street Journal]Reply14 repliesLeave a reply


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The Most Important Life Saving Devices – Automated External Defibrillators
In America, every year sudden cardiac arrest kills more people than breast cancer, AIDS, house fires, prostate cancer, firearms, and traffic accidents combined (National Center for Health Statistics); the American Heart Association says 50,000 lives could be saved every year if automated external defibrillators (AEDs) were more widely available (currently only 5% of cardiac arrest victims are saved in the U.S. each year). Any second a defibrillator could save your life - is there an aed near you?
For years you've seen on television or movies "patients" in cardiac arrest saved by a defibrillator, but until recently defibrillators were only available in medical offices and hospitals. Thanks to incredible advancements in medical and computer technology, automatic external defibrillators are available for home or office and easy enough to be used by virtually anyone.
Why Defibrillation Works
Typically the heart forms electrical impulses 60-100 times a minute. This creates what is called the "normal sinus rhythm" and it is what makes up the peaks you see on cardiac monitors (which you've also seen on tv). During cardiac arrest (or ventricular fibrillation) there is no regular pattern to the electrical impulses which means the heart can't contract (so it can't eject blood). Defibrillation delivers electrical energy to the heart to allow the heart to resume regular electrical impulses (and therefore regular heart function).
Time is Key For Life Saving Defibrillation
For every minute ventricular fibrillation occurs without treatment, the chances of resuscitation decrease by 10 percent; after 10 minutes without treatment very few people survive. With the average response time for emergency vehicles and personnel at about 6 minutes to mid-size urban communities, it is easy to understand how quickly chances of survival diminish if you have to wait for EMTs to start treatment. Automated external defibrillators (AED) are such life savers, numerous states have passed legislation requiring AEDs to be present in public buildings.
Where Should Automatic External Defibrillators Be Placed?
The American Heart Association advises businesses follow the "3-minute rule": which means you should be able to walk briskly from your work station to the closest AED and bring it to the cardiac arrest victim within 3 minutes. Any place of business, large or small, should have automatic external defibrillators near employees. While some small businesses list AED cost as prohibitive, should an employee or customer ever go into cardiac arrest the ability to save their life will be much greater than buying a cost effective AED.
Businesses aren't the only places that should have external defibrillators, though. An author with Pediatric Clinics of North America reports that as many as 7,000 children are struck down by sudden cardiac arrest each year. With that in mind, day cares, schools, family restaurants, and a wide variety of places where children congregate should also have automatic external defibrillators within easy reach. AEDs are now cost effective enough for families to purchase them and have one at home for emergencies (many home owner associations purchase automated external defibrillators to be put in the community clubhouse or pool area).
Who Can Use AEDs?
Automated external defibrillators can be used on people of all ages; there are different electrode pads for small children and adults. While there is training available on how to use an external defibrillator, AEDs are incredibly easy to use, and offer audible (and/or visual) prompts that guide a user through the entire process. There are even microprocessors within the AED that measure the heart rate of the person with cardiac arrest, and deliver a shock only if the computer determines defibrillation is indicated by their heart rhythm.
The Best AED
There are numerous AEDs currently on the market. One of the most affordable defibrillation solutions is the First Voice SET System with First Voice EID, which won the 2006 SafetyXChange Best New Safety Product Award. This interactive, incredibly user friendly, portable first aid system is specially designed to assist you in various emergency scenarios and can include the HeartSine AED defibrillator. Seven different bags are labeled and color-coded by trauma which correspond to color-coded buttons on the First Voice Emergency Instruction Device (EID); users are coached through over 30 medical traumas from start to finish.
Philips is one of the leading AED brands, and the Philips AED HeartStart Home Defibrillator is the first home automated external defibrillator available without a prescription for use by virtually anyone. Designed only to give an electrical shock if needed, the AED HeartStart Home Defibrillator not only provides clear instructions to talk you through the entire defibrillation process, it additionally senses and adapts the instructions based on your actions. This AED runs daily self checks and warns of low battery power or needed maintenance.
The Philips Home Defibrillator is similar to the Philips HeartStart OnSite Defibrillator, which is one of the smallest and lightest defibrillators currently on the market (3.3 lbs). Philips designed the HeartStart defibrillators to be the easiest-to-use, and provide everything necessary for the ordinary person in the extraordinary moment.
Even lighter is the First Voice HeartSine Samaritan PAD AED at 2.4 lbs,; this defibrillator battery has a shelf life of 3.5 years (from date of manufacture) making it more cost effective than AEDs requiring separate battery units. Like the Philips defibrillators, the First Voice HeartSine AED signals with a green light if a shock is needed or else CPR can be performed. Calm audible and visual instructions take the user through the entire defibrillation process to aid someone suffering from cardiac arrest. This AED comes with its own storage cabinet and is a convenient purchase for businesses or schools.
Whether you are considering purchasing an AED for your home, work, or school, don't wait to make this life saving purchase. Automated external defibrillators save lives daily across the country, and should someone you love be struck by cardiac arrest you'll want it to happen within a 3 minute walk of an AED. Some legislation is moving towards making AEDs as commonplace as fire extinguishers, but you don't have to wait for bills to be passed to keep your loved ones safe with an automatic external defibrillator nearby in your own home, office, or regularly attended building.


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Watson Pharmaceuticals Inc. (WPI) is one of my 10/10/10 stocks. My philosophy is that the only way to have a portfolio that will return in excess of 10% is to only buy stocks that are projected to have a 10% increase in Revenue, Earnings and Total Return. Why would you not own WPI? In the past five years, there has been a 179.41% increase in price, as this graph provided by Barchart shows:
The stock has stayed on a steady roll and during the last six months. While the market as measured by the Value Line Index fell 4%, Watson Pharmaceuticals was up 24%:
Watson Pharmaceuticals, a specialty pharmaceutical company, engages in the development, manufacture, marketing, sale, and distribution of generic and brand pharmaceutical products in the United States, western Europe, Canada, Australasia, Asia, South America, and South Africa. The company offers its products for therapeutic categories, such as central nervous system, cardiovascular, hormones and synthetic substitutes, anti-infective agents, and urology. It operates in three segments: Global Generics, Global Brands, and Distribution.
The Global Generics segment develops, manufactures, and sells generic pharmaceutical products, as well as distributes generic versions of third parties brand products. This segment offers various dosage forms, such as oral solids, transdermals, injectables, inhalation products, and transmucosals for indications, including pregnancy prevention, pain management, depression, hypertension, and smoking cessation.
The Global Brands segment promotes and co-promotes Rapaflo, Gelnique, Trelstar, Androderm, Crinone, ella, INFeD, Generess, sodium ferric gluconate, AndroGel, and Femring branded products; and markets its products through sales professionals. It also sells various non-promoted products.
The Distribution segment distributes generic and select brand pharmaceutical products, vaccines, injectables, and over-the-counter medicines to independent pharmacies, alternate care providers, pharmacy chains, and physicians offices. The company sells its generic and brand pharmaceutical products primarily to drug wholesalers, retailers, and distributors, including national retail drug and food store chains, hospitals, clinics, mail order, government agencies, and managed healthcare providers, such as health maintenance organizations and other institutions. Watson Pharmaceuticals, Inc. was founded in 1983 and is headquartered in Parsippany, New Jersey. (Source: Yahoo Finance profile)
Barchart technical indicators
- 100% Barchart technical buy signal
- Trend Spotter buy signal
- Above its 20, 50 and 100 day moving averages
- 5 new highs and up 3.67% in the past month
- Up 26.16% in the past year
- Up 179.41% in the past 5 years
- Relative Strength Index 67.55%
- Barchart computes a technical support level at 79.35
- Recently traded at 82.70 with a 50 day moving average of 76.55
Fundamental factors
- 17 Wall Street brokerage firms have assigned 24 analysts to make recommendations on this stock
- Analysts project revenue will increase by 20.00% this year and another 46.10% next year
- Earnings are estimated to be up 21.40% this year, an additional 40.10% next year and continue to increase by an annual rate of 12.37% for the next 5 years
- These numbers resulted in analysts making 8 strong buy, 9 buy and 7 hold recommendations to their clients
- Analysts think if their numbers are correct investors could see an annual rate of return in the 10% - 14% range during the next 5 years
- The balance sheet rates a B++
- The P/E ratio is 13.30 which is less than the market P/E of 15.00
- No cash dividend at the present time
- Acquisitions have gone smooth
- They just received a favorable ruling to produce a generic version of Lidoderm
Investor interest
- As mentioned above, Wall Street brokerage analysts had no underperform or sell calls out
- Individual investors, as measured by comments on Motley Fool, voted 89% that the stock will beat the market
- Firms positive on the stock include CitiGroup, JP Morgan, Barclays and Goldman Sachs
- Short interest peaked in mid-may around 4+ million shares and fell to just under 3 million share recently
- The Street gives the stock a B rating
Price vs its peers
The market has looked at all the pharmaceuticals favorably this year and Watson was up 23% during the period, while Pfizer (NYSE:PFE) was up 27%, Novartis (NYSE:NVS) up 4% and Merck (NYSE:MRK) up 32%:
Watson Pharmaceuticals is a growth stock that is projected to have a 10% increase in revenue, earnings and total return. No major road blocks appear on the horizon and lately the stock has shown favorable performance against its moving averages and turtle channels:
Disclosure: I am long WPI, PFE, MRK. I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it (other than from Seeking Alpha). I have no business relationship with any company whose stock is mentioned in this article.


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Tag Archives: gum
Turkey Day Troubles? + Chewing Gum + Anti-Inflammatory Drugs
TURKEY DAY TROUBLES? A four-day weekend of feasting with family is supposed to be an all-around good thing. But if … More »
Posted in Body Buzz, Uncategorized, Your Body
Tagged exercise, gum, Holiday, ibuprofen, lashes, midday slump, Thanksgiving, turkey
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Yay, fall! My favorite season is finally upon us; I can stop sweating and I can go apple-picking with my family! If you've never done this, the time is now. You get to eat lots of apples and do silly stuff like this:
Of course, when you pick apples you end up with lots and lots of them. Like, more than you'd ever need or want. But you're not going to waste any, are you? No, you're going to eat them for breakfast, lunch, and dinner. And you're still going to have way more than you want.
In order to make a significant dent in your pile, you've got to find a recipe that requires a large number of apples. I've got just such a recipe: applesauce.
And this applesauce, my friends, is about the easiest you're gonna find. Not only do you just throw everything in the slow cooker, but you don't even have to peel the dang apples! Keeping the skins on also makes this sauce super healthful, as most of the apples' nutrients are in their peels. Apples are not only popular with kids and adults alike, but they are also a good source of Vitamin C, fiber, and polyphenols.
yields: 5 1/2 - 6 cups
- about 15-20 small/medium apples (preferably organic), cored and quartered*
- juice of one lemon
- 1/4c orange juice
- 1-2T vanilla
- 1/2t cinnamon**
**I'm a believer that a little cinnamon goes a long way; this amount gives a nice hint of the spice but you should feel free to add more, if it floats your boat.
Fill the Crockpot with your apples, add the rest of your ingredients, and give it all a quick stir. Set it to cook on low for five to six hours. The smell of applesauce cooking away is fantastic; people pay good money for candles that don't smell half as good.
My apples were fully cooked at about five hours but I left them in for almost six hours; they get more of that gorgeous caramelized flavor and richer color the longer they cook. (Another bonus of keeping the skins on is that the sauce becomes a lovely berry hue).
My hubby likes lots of extra cinnamon on his. |
OK, so you have all this luscious applesauce...now what? Some suggestions:
- freeze small batches for future use
- add to muffin and pancakes batters
- put in the custards when you make french toast or bread pudding
- stir into plain yogurt
- add a few spoonfuls to sweeten smoothies
- pack in individual containers to add to lunch boxes
- top with chopped walnuts, granola, and/or flax or chia seeds
- put a dollop on latkes (potato pancakes)
- serve alongside meats, such as roast pork
- share a jar with friends who didn't get to go apple picking!
The color of your apples' skins will determine the hue of your sauce |
What's your favorite way to use loads of apples?
For some other recipes in our "Real Convenience Food" series check out: Asparagus and Pea Soup; Tomato, Cucumber & Onion Salad with Feta Cheese; and Caramelized Onion and Mushroom Soup with Asiago Cheese. And don't forget one of our most popular posts ever: our Foolproof Caramelized Onions, made in a Crockpot!
This post contains affiliate links, so I make a small commission if you purchase through my links—which helps to keep this blog running.


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The Chariot from the Zerner Farber Tarot Zerner/Farber Editions, 1997 |
Bohemian Path Tarot |
Use the links below to find free tarotscopes and, articles about the tarot and it's uses. If you live in Los Angeles, you can book a reading, request information about tarot classes, or find out about my next appearance. |
Copyright 2007-2013 Bohemian Path Tarot Stealing intellectual property is bad karma. |


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J. Jill is one of the best American retail catalog that specializes in the retail of women's footwear,apparel and accessories. They will often introduce discount and even you can save up to 60% on selected J. Jill products at its store catalog. Most customer rate high so that's why they are growing day by day with positive feedback.
There recent offers include
$20 Off $80+ Sitewide => DEC20F
Shipping rate upto $5.95 => FSEM12
FREE SHIPPING over $75 => PRW221
Just visit their official website and redeem you offers before they got expire


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District Attorney for the Eighth Judicial District of Colorado
Cliff attended CSU and obtained a BA in speech. He attended Law School at CU-Boulder and graduated in 1979 with a Juris Doctorate Degree. Cliff served as a municipal prosecutor in the City of Arvada from October of 1979 until March 31, 1980. On April 1, 1980, he started as a Deputy District Attorney for the Eighth Judicial District in Fort Collins. Cliff worked his way up through the ranks. Cliff has handled all manner of cases: from the most serious and sensitive cases to the most routine. Cliff has been the recipient of the Larimer County Bar Association's Professionalism Award as well as the Conrad Ball Award for making significant contributions to the quality of justice in Larimer County. Cliff sincerely believes that the role of the prosecutor is to "seek justice and follow the truth" and that will continue to be the goal of this office.


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I noticed that I am getting alot of segmentation faults on my php, including when I do a php --version. Here is the output: PHP 5.2.6-1+lenny2 with Suhosin-Patch 0.9.6.2 (cli) (built: Jan 26 2009 22:41:04) Copyright (c) 1997-2008 The PHP Group Zend Engine v2.2.0, Copyright (c) 1998-2008 Zend Technologies Segmentation fault I have traced the segmentation faults down the the mysql and mysqli php extension. Any ideas of what I need to do to fix this? Things seem to be working fine, but I am fearful of doing the upgrade to 3.0.1 from 3.0.9RC due to this error. Thank you, technoid
Was having the same problem. Migrated the virtual machine arround without any luck. Did what was advised at: http://bugs.debian.org/cgi-bin/bugreport.cgi?bug=493045 1) Install php5-dev, libmysqlclient15-dev and the source of php5 (apt-get source php5) 2) cd php5-5.2.6.dfsg.1/ext/mysql/ 3) run "phpize" in this directory 4) ./configure && make && make install All is fine now.


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Veterans of the Ulster Division prepare to leave Belfast to attend a commemoration at Thiepval.
Dermot Mullane reports on the departure of sixty seven veterans of the Ulster Division to a commemoration of the Battle of the Somme sixty years after it began.
John Saunders tells reporter Jim Dougall that he went to war when he was seventeen and he remembers so many of his friends and neighbours from the Belfast Brigade who were injured or killed.
Another veteran Mr Wilson was in the cavalry and recalls men falling asleep on their horses.
Title: |
Ulster Veterans Leave For Commemoration |
Clip Duration: |
00:03:15 |
Material Type: |
Video |
Clip Title: |
Ulster Veterans Return To The Somme |
Series Title: |
RTÉ News |
Information: |
RTÉ News reports on veterans of the Ulster Division leaving to attend a commemoration at Thiepval. Broadcast 1 July 1976. |
Local Keywords: |
First World War, World War 1, Great War, Wars, Conflicts, |
Coverage: |
Ireland, Belfast |
Topic: |
Wars and Conflict |
Contributor(s): |
Dermot Mullane (Reporter), Jim Dougall (Reporter) |
Publisher: |
First Broadcast Channel: |
Broadcast Date: |
01/07/1976 |
Production Year: |
1976 |
Country of Production: |
Ireland |
Original Identifier: |
IPR Restrictions: |
Rights Reserved - Free Access |
Rights, Terms and Conditions: |
Copyright RTÉ. This material may not be replicated in any form or manner without the prior express permission of RTÉ. Any form of reproduction in print, television, video, multimedia, web site or other electronic media or any form of dissemination for commercial or non-commercial use must be licensed by the RTÉ Libraries and Archives.
If you wish to licence video or audio clips, still images or text, or would like further guidance please contact us. RTÉ Libraries and Archives are committed to respecting the copyright of others and have attempted to source and credit the copyright owners of all material used here. RTÉ would like to hear from any copyright owners who are not properly identified here so that the necessary corrections can be made. If you feel your copyright has not been respected please contact us. |
Item Type: |
part/extract |
Colour: |
Colour |
Sound: |
Mono |
Aspect Ratio: |
4:3 |
Language: |
English (eng) |


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Americans Abroad
To Henry James, as to his fellow expatriates Whistler and Sargent, the culture of the Old World was "vast, vague and dazzling," yet they could never quite forget or abandon the New
October 1961 | Volume 12, Issue 6
Whistler, Sargent, and James—those are the names we think of when we contemplate that first thin line of expatriates. Other Americans came increasingly to live in Europe for various periods during the late decades of the nineteenth century, and still others—businessmen, socialites, writers—shuttled between the two continents, sometimes maintaining homes here and abroad. But the two painters and the novelist stood out by the definitiveness with which they made their choice and by the awareness that they brought to its implications.
When in the fall of 1875 James settled down in a "snug little troisième" near the Place Vendôme in Paris, he was repeating the first step in the pilgrimage made by Whistler. This eccentric man, half visionary and half drawing-room wit, had also spent much of his youth in Europe, mainly at St. Petersburg, where his father, a former United States Army engineer, had been invited by the czar to supervise the building of a railroad to Moscow. Later young Whistler had attended West Point—at the time when Robert E. Lee was superintendent—only to be expelled after committing a series of half-comic escapades and flunking chemistry ("Had silicon been a gas," he recalled years later, "I would have been a major-general"). Then Secretary of War Jefferson Davis found him a job etching and mapping at the U.S. Coast Survey Office, but he had spent more time in Washington salons than at his job. Finally, in 1855, the memory of Henri Murger's Scènes de la Vie de Bohème fresh in his mind, he had gone to Paris to test the talent for painting which he had long displayed.
In 1874, John Singer Sargent had come to Paris to study art. Unlike James and Whistler, Sargent had not been born in America, although his roots there went far back. His father was a surgeon, a moody man whom today we would call neurotic, who had taken his family to Europe after a troubled career in the States. John had been born in Florence, had traveled with his parents throughout the Continent, in an endless nomadic existence, (James was later to write a story, The Pupil, about this talented youth and his restless, socially ambitious parents), and finally, at eighteen, he had come to Paris to begin his career.
By 1875 Whistler had long since left Paris for London, after having failed to make much of a dent in the French scene. Sargent was to follow him because he made the wrong kind of dent. After several years of study with a leading French portrait painter, Carolus-Duran, he had just begun to make a reputation when he was brought up short by one of those artistic scandals which the nineteenth century contained in abundance. His daringly accurate portrait of Madame Gautreau, an unorthodox beauty who dressed provocatively, used lavender face-powder, and dyed her hair scarlet, was exhibited at the Salon of 1884, thereupon bringing down upon Sargent the anathemas of polite French society, on whose good will he depended for his commissions.
A year of dwindling revenues persuaded him to try his luck in England, though not without some ironically tinged misgivings. "There is perhaps more chance for me there as a portrait painter," he wrote to a friend, "although it might be a long struggle for my painting to be accepted. It is thought beastly French."
James had preceded Sargent across the Channel. He spent only a year in Paris, in fact, during which time he served as correspondent for the New York Tribune and made the acquaintance of such men as Turgenev, Flaubert, Zola, the Goncourts, and Daudet. But though we find him writing to William Dean Howells that "I am turning into an old and very contented Parisian," James was never more than a fascinated visitor to that city. England was the place for him, as he had always known. The decision to go there was abrupt, and the transformation rapid. Two months after the letter to Howells he writes to William James: "I am turning English all over. I desire only to feed on English life and the contact of English minds—I wish greatly I knew some."
He was not long in overcoming the deficiency. Within a year he was able to write to his sister Alice that he had dined 107 times in private homes the previous winter, his fellow guests ranging from Tennyson to Gladstone. He quickly struck up friendships with Fanny Kemble, the Irish writer George Moore, and later with George du Maurier, Robert Louis Stevenson, and Edmund Gosse. Two years after his arrival his short novel Daisy Miller was published, making his name for the first time widely known to English readers. Yet even before that we find him writing that London was "the place in the world in which, on the whole, I feel most at home."


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Full profile →'">
The author is a Forbes contributor. The opinions expressed are those of the writer.
Continued from page 1
I reached out to all of the brands involved in this story to get their insights. Nickelodeon did not respond, and Red Bull provided the following response, "Since this investigation is ongoing, we will not be able to provide comment at this time." Both Mojang and Play N Trade took the time to research what was happening and answered my questions. Following are insights from Mojang's Chief Operating Officer Vu Bui and Play N Trade's Marketing and PR Director Teresa Aragona.
For most companies, their intellectual property is a valuable asset that they protect vigilantly, but what happens when a misuse of intellectual property, like what happened with Meeting of the Mines, occurs and the companies affected by it don't learn about the problem until after the fact? Aragona says, "If we learn about the event in time, Play N Trade makes attempts to contact the event organizers or company using our logo without permission. This is to inform them that legally they must remove the logo or any use of it on all of their materials. Play N Trade also takes the appropriate steps to do a public announcement denouncing any affiliation with the event or company. From a franchise perspective, we inquire with nearby stores to see if they had any involvement. Once it is confirmed that they have not participated, we continue to inform them of the situation in case they are approached by the media or customers from the event."
Mojang responds to the misuse of its trademarks on a case-by-case basis. Bui explains, "While we do take protection of our IP and brand seriously, the popularity of Minecraft has made it impossible to see everything that is done with our name. When we see something done wrong with it, our approach is usually reaching out directly, instead of through lawyers, to give people a chance to explain what they did and why. Often times it's just people in the community doing things they didn't realize were wrong, and we give people a chance to fix it. Sometimes it's obvious that things were done intentionally, and we take a harder approach when it's obviously not someone who is part of our community, but rather a company or person trying to take advantage of the community instead. There is a big distinction in our eyes and we treat those things very differently."
A critical part of protecting intellectual property and brand reputation is monitoring the brand and brand assets, particularly online. Play N Trade is very proactive in monitoring its online reputation. Aragona explains, "We consistently check Google and social media to make sure our logo has not been used without our permission. We also have the unique system of hundreds of franchise owners that care about the brand as much as we do. We have a franchise social network where we communicate with all franchisees on a daily basis and they alert us if our logo is used unlawfully."
For Mojang, monitoring its brand assets is more challenging. Bui says, "Monitoring is a difficult thing. We are a rather small company still---35 people---and we'd rather focus on doing cool things that benefit people, rather than spend too much time trying to stop people from doing things we don't like. When you have limited resources you have to choose how best to use them, and we'd rather be actively doing interesting things that people will love rather than spend too much time just defending what we've already done. That being said, we do have a small outside team that is actively looking for things that aren't okay according to our brand guidelines, with a focus on protecting the community from things that aren't what we'd consider of adequate quality that would benefit them.
"We have what I consider to be very open brand guidelines. We allow people to do some great things with our brand and IP, but there have to be limits. Some people make their entire living off of using Minecraft assets---for instance, some YouTube content creators---and that is something we love and encourage. However, we don't want shipments of low quality counterfeit merchandise headed to stores where parents will buy items thinking they are legitimate."
Despite their best efforts, companies are unlikely to catch all trademark violations and misuses of their brand assets, but the very real issue at hand is how these acts of misuse can negatively affect the brand, and ultimately, its profits. Both Mojang and Play N Trade have plans in place to prevent an incident like Meeting of the Mines from happening in the future. Aragona shares, "We will continue to monitor and use the assistance of our franchisees to make sure our brand and trademark are protected. With the help of our franchisee Janet Jacobsen from Play N Trade Orlando, who was the eyes and ears as the event unfolded, we were able to turn this negative situation to a positive. Janet has offered to throw a Minecraft event for all the children that were disappointed that day."
Mojang is revamping its procedures so there is less of a chance of consumers being victims in the future. Bui explains, "We were already working on guidelines for community-run events to prevent this exact type of thing from happening. They would be out there for everyone to see, so if you were going to go to an event, you could also look and see if the event seems to be following the guidelines. This can help you decide whether the event is something you should attend. We can't police the world, so it's likely that these things will crop up here and there undetected by us. We can, however, try to educate people and warn them to be vigilant before sending someone their money. We won't be able to reach everyone, of course, but luckily our community is vast and they are a caring bunch. They usually spot these things way before we do."
Lessons for Brands
Your brand will be misused, and you must take its misuse seriously. Your brand is your most valuable asset. If people don't consistently believe in your brand promise, long-term profits will be affected. Remember, brand confusion is the number one brand killer.
Today, consumers expect companies to step up to the plate and be good corporate citizens. Develop a system to identify and respond to these types of situations that are not only illegal but also damage the perception of your brand in consumers' minds. Even a delayed response that happens after the fact is better than no response at all. CSR comes in many shapes and sizes, and it's directly related to your brand reputation. Don't undervalue it.


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Temozolomide,Thiotepa and Carboplatin With Autologous Stem Cell Rescue Followed by 13-cis-retinoic Acid in Patients With Recurrent/Refractory Malignant Brain Tumors
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
The purpose of this study is to:
Find out how safe and effective (by monitoring the good and/or bad effects) treatment with high dose temozolomide, thiotepa and carboplatin with stem cell rescue followed by 13-cis-retinoic acid has on children and adolescents with recurrent/refractory brain tumors
Find out how the body uses 13-cis-retinoic acid by studying the your blood levels and proteins in the blood that break down the 13-cis-retinoic acid
Determine how well 13-cis-retinoic acid penetrates into the spinal fluid.
Condition | Intervention | Phase |
Brain Tumors |
Drug: temozolomide, thiotepa, carboplatin, 13-cis-retinoic acid |
Phase 2 |
Study Type: | Interventional |
Study Design: | Intervention Model: Single Group Assignment Masking: Open Label Primary Purpose: Treatment |
Official Title: | NYU 05-40 PBMTC ONC-032P:High Dose Temozolomide,Thiotepa and Carboplatin With Autologous Stem Cell Rescue (ASCR) Followed by Continuation Therapy With 13-cis-retinoic Acid in Patients With Recurrent/Refractory Malignant Brain Tumors |
- • To assess the event-free survival and overall survival of patients with recurrent or refractory medulloblastoma/ primitive neuroectodermal tumors [ Time Frame: Day +42 and Day +77 ]
- To evaluate the toxicity of of 13-cis-retinoic acid following high dose temozolomide, thiotepa and carboplatin with ASCR. [ Time Frame: One year ]
Enrollment: | 46 |
Study Start Date: | October 2005 |
Study Completion Date: | August 2015 |
Primary Completion Date: | August 2015 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
Myeloablative Chemo-Temozolomide, Thiotepa, and Carboplatin. |
Drug: temozolomide, thiotepa, carboplatin, 13-cis-retinoic acid
13-cis-retinoic acid, when absorbed, may be subject to first-pass metabolism and subsequent plasma (and tumor) concentrations will depend on the rate of metabolism to the inactive 4-oxo metabolite.
Detailed Description:
Researchers have used high doses of combination chemotherapy followed by a stem cell rescue to treat recurrent brain tumors with moderate success. High dose chemotherapy with stem cell rescue has resulted in long term survival of about 25% in patients with several different types of recurrent brain tumors. Stem cells are cells in the bone marrow that produce blood cells. The stem cells are collected from the blood of the patient before the high dose chemotherapy. Patients are given high doses of chemotherapy to kill every brain tumor cell, but in the process the cells of the bone marrow are also killed. The previously collected stem cells are then infused into the patient to rescue the bone marrow and allow for healthy blood cells to re-populate and grow in the bone marrow. Initial studies used the drug etoposide along with carboplatin and thiotepa for the high dose chemotherapy. Patients had severe side effects, especially severe mouth-sores, thought mainly due to the etoposide, and some patients died from these side effects.
Recent studies have shown that a new drug, temozolomide, is active against some types of brain tumors. When it was given as a single drug to children with solid tumors, the side effects were considered to be tolerable. Temozolomide is given by mouth. In this study, researchers want to give high dose chemotherapy that includes the drugs temozolomide in place of etoposide, along with thiotepa and carboplatin. Patients will then be given their own stem cells back to rescue the bone marrow from the chemotherapy. A preliminary trial using this new drug combination was performed and has shown that patients tolerate this drug combination, even at the very high doses that will be used in this protocol.
Another drug that is being used in pediatric cancer treatment is called 13-cis-retinoic acid. This drug is closely related to vitamin A. It is taken by mouth. Cancer cells are immature cells that have not "grown up" into adult cells that do work in the body. 13-cis-retinoic acid is thought to act on some types of cancer cells to make them mature into cells that function in the body. It has also been shown in the laboratory to cause some brain tumor cells to undergo apoptosis. It has been used in other types of pediatric cancers and research is just beginning to use it for treatment of recurrent brain tumors. In this study researchers want to give you 13-cis-retinoic acid for 6 months after you recover from the high dose chemotherapy with stem cell rescue.
Ages Eligible for Study: | 6 Months to 21 Years (Child, Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Patients with recurrent or refractory medulloblastoma/PNET, CNS germ cell tumors, ependymomas, AT/RT, high grade glioma and other malignant brain tumors. Brainstem gliomas are eligible if residual disease is < 1.5cc and if the patient is off decadron.
- Patients must have recurrent or refractory disease following at least one prior course of therapy and must have minimal residual disease defined as < 1.5 cm2 of enhancement. Patients with + CSF cytology, linear or fine nodular leptomeningeal disease are eligible.
- Adequate hematologic, renal, liver, and cardiac function as demonstrated by laboratory values performed within 21 days, inclusive, prior to administration of temozolomide.
- Patients must have an adequate number of autologous stem cells available defined as a minimum of 2 x 106 CD 34+ cells/kg and preferably at least 5 x 106 CD 34+ cells/kg.
Exclusion Criteria:
- Previous myeloablative therapy
- Frequent vomiting or medical condition that could interfere with oral medication intake (e.g., partial bowel obstruction)
- Previous or concurrent malignancies at other sites with the exception of surgically cured carcinoma in-situ of the cervix and basal or squamous cell carcinoma of the skin. Patients with prior malignancies which have not required anti-tumor treatment within the preceding 24 months are eligible.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00528437
United States, Arizona | |
Phoenix Children's Hospital | |
Pheonix, Arizona, United States, 85016 | |
United States, Georgia | |
Emory University | |
Altanta, Georgia, United States, 30322 | |
United States, Hawaii | |
Hawaii Pacific Health | |
Lihue, Hawaii, United States, 96766 | |
United States, Illinois | |
Children's Memorial Hospital | |
Chicago, Illinois, United States, 60614 | |
United States, Indiana | |
Riley Hospital for Children | |
Indianapolis, Indiana, United States, 46202 | |
United States, Minnesota | |
Children's Hospital and Clinics of Minnesota | |
Minneapolis, Minnesota, United States, 55404 | |
United States, New York | |
Roswell Park Cancer Institute | |
Buffalo, New York, United States, 14263 | |
Steven and Alexandra Cohen Children's Medical Center of New York- North Shore LIJ | |
New Hyde Park, New York, United States, 11040 | |
NYU Hassenfeld Center | |
New York, New York, United States, 10016 | |
United States, Ohio | |
Nationwide Children's Hospital | |
Columbus, Ohio, United States, 43205 | |
United States, Pennsylvania | |
Children's Hospital of Philadelphia | |
Philadelphia, Pennsylvania, United States, 19104 | |
United States, South Carolina | |
Medical Univ. of South Carolina | |
Charleston, South Carolina, United States, 29425 | |
United States, Tennessee | |
Vanderbilt Univ. | |
Nashville, Tennessee, United States, 37240 | |
United States, Texas | |
Children's Medical Center of Dallas | |
Dallas, Texas, United States, 75235 | |
MD Anderson Cancer Center (MDACC) | |
Houston, Texas, United States, 77030 | |
United States, Virginia | |
Virginia Commonwealth Univ. | |
Richmond, Virginia, United States, 23284 | |
Canada, Ontario | |
Princess Margaret Hospital | |
Toronto, Ontario, Canada, M5G 2M9 |
Principal Investigator: | Sharon L Gardner, M.D. | New York University School of Medicine |
Responsible Party: | New York University School of Medicine |
ClinicalTrials.gov Identifier: | NCT00528437 History of Changes |
Other Study ID Numbers: |
NYU 05-40 H12853 PBMTC ONC-032P ( Other Identifier: Pediatric Blood and Marrow Tranpalnt Consortium ) |
Study First Received: | September 10, 2007 |
Last Updated: | January 25, 2016 |
Keywords provided by New York University School of Medicine:
Recurrent or refractory medulloblastoma/PNET CNS germ cell tumors Ependymomas |
AT/RT High grade glioma Other malignant brain tumors |
Additional relevant MeSH terms:
Brain Neoplasms Central Nervous System Neoplasms Nervous System Neoplasms Neoplasms by Site Neoplasms Brain Diseases Central Nervous System Diseases Nervous System Diseases Temozolomide Carboplatin Dacarbazine Thiotepa |
Tretinoin Isotretinoin Antineoplastic Agents Antineoplastic Agents, Alkylating Alkylating Agents Molecular Mechanisms of Pharmacological Action Myeloablative Agonists Immunosuppressive Agents Immunologic Factors Physiological Effects of Drugs Keratolytic Agents Dermatologic Agents |
ClinicalTrials.gov processed this record on March 30, 2017


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The best way to describe Pedro Almodóvar's latest, "I'm So Excited!," is to think of it as "Airplane!" repurposed into a Spanish telenovela and staged by a maniacal gay cabaret troupe. So, no, it's not one of the master's more enduring works.
If you can get over that and are in the mood for a giddy trifle, this may be your bag of slightly stale peanuts. Almodóvar seems roused by the challenge of staging a madcap farce in the cramped confines of an airplane, or maybe he's just roused, period: "I'm So Excited!" might be the horniest movie ever made by a major filmmaker. It's broad, occasionally uproarious, a little wheezy, and every so often inspired. If nothing else, it beats an in-flight movie.


text:
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Showing Results: Most Recent
This review is from: BELKIN BE112230-08 8 Feet 12 Outlets 3780 Joules Surge Protector with Telephone and Coaxial Protection
Pros: This does exactly what it's supposed to do. I've bought two of them and haven't had a single problem.
Cons: N/a
Other Thoughts: I will admit I've never had the chance to put these to the test. E.g. I was never playing a game in a storm and experienced a power surge, that could possibly have damaged my system based on whether or not this surge protector managed to protect from the surge. However, after some research, I was assured that with surge protectors, you generally get what pay for. This won't give you the protection that a giant $200 surge protector would, but for the price, it should do pretty well.
READ FULL REVIEWThis review is from: ZALMAN Ultra Quiet Notebook Cooler ZM-NC1000 Black
Pros: I've owned this thing for a good 6 months. I tried the cooler master 1st, and that was old trusty for about a years and a half, but then it started making this funny noise. I actually fixed the cooler master after buying this, so I guess it's still fine, but this thing is much better. 1st, the fans are adjustable. 2nd, the fan blades are concealed, so having this on your lap won't mess with the cooling fan's blades. It's quiet, it's sexy, and it's at a far better price than the one I bought it at. I was a little worried that it being closed off the way it is would make it dusty and subject to break, but I have yet to experience any such problems, and enough people on here claim they've had it for a long time and it hasn't failed them yet, so I have to trust that.
Cons: My cooler master came with a little strap that basically fastens the laptop to the cooling pad. This cooler does not come with this. I hate to deduct an egg over something so petty, especially since I already have the strap, BUT this strap IS NECESSARY. If you've ever tried to pull your laptop open with one hand, and accidentally started tipping it off the back of your cooling pad, you probably understand where I'm coming from. Now I'm sure that if these little straps were sold separately, they would only be a dollar or two, in which case this pad would get 5 eggs, because everything I needed would be readily affordable and available. However, I can't find these straps for the life of me, and after having used one for so long, I can't stand using laptops on cooling pads that lack them.
READ FULL REVIEWThis review is from: SONY PS3 Media/Blu-ray Disc Remote Control
Pros: It works with my Sony 3D display. It works with my Ps3. It works with my Roommates 3D display, in the same room, but it is focused enough to target the one it is being pointed at directly. All in all, this remote does what it says it will. If you're feeling lazy, grab it. It's at a solid price.
Cons: N/a


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Building Bunk Beds 01:07
Step 1
Remove the Baseboards
Begin the process by removing the baseboard molding (figure A) from the walls where the wood cleats will be attached. The headboard and sideboard of the bed are to be flush with the wall. Remove the molding using a pry-bar, saw and chisel.
Step 2
Attach the Cleats to the Wall
Measure out from the wall paneling and mark for the placement of the wall cleats. Placement of the cleat closest to the paneling should allow for a 3/4" gap between the cleat and edge of the paneling. The gap will allow room for the decorative post that will be added later. Fasten the cleats to the wall using construction adhesive and finishing nails. Repeat the steps on the opposite end of the bed.
Step 3
Attach the Headboard, Molding and Footboard
With the cleats installed, position the headboard unit in place and attach it to the cleats (Image 1). Corner molding can be added where the bed meets the paneling (Image 2). Install the molding with finishing nails to achieve a clean, decorative finish. Attach the foot-board section to the cleats at the opposite end by toe-nailing with finishing nails. With the headboard and foot-board in place, position the center panel (Image 3) and attach it directly to the wall using finishing nails.
Step 4
Install the Side Rails
Position the first bottom side-rail on the center panel, and use a carpenter's level to ensure that it is perfectly level. Use wood shims to hold the side-rail in position and level, and attach the side rail to the frame of the bed using a surface-mounted bed-rail bracket (Image 1). Fasten the bracket to the frame and rail using wood screws. Repeat the process for the second (outer) bottom rail, taking into consideration the width of the bed slats (Image 2). Repeat the steps for installation of the two rails for the top bunk (Image 3).
Step 5
Add the Trundle and Mattresses
With all of the fixed components in place, the sliding trundle can be installed under the bottom bunk. Add the plywood supports and install the mattresses on the upper and lower bunks.
Step 6
Add the Ladder
Finally, install the ladder at the foot of the bunks. The finished bunk beds, with the pull-out trundle, offers flexibility. The side rails are removable in case you ever want to convert back to a single bed.


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Making the Common Core Text Exemplars Accessible to Middle Graders
This article from Voices from the Middle (May 2013) provides an overview of the Common Core text exemplars and gives examples of ways teachers can group text exemplars and other trade books in ways that will support middle graders' understanding of complex texts.
Building background by supplementing text exemplars with other titles is particularly emphasized. Suggestions for grouping exemplars and other books on topics like the Great Depression, slavery, art, and architecture are provided. Classic books by authors like Virginia Hamilton, Walt Whitman, and Frederick Douglass are featured, as are more contemporary titles by authors like Elizabeth Partridge, David Macaulay, and Russell Freedman.
Access to this resource has been provided by the National Council of Teachers of English, an NCLE Stakeholder Organization.
Attachment | Size |
Making the Common Core Text Exemplars Accessible to Middle Graders (PDF) | 1.21 MB |


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Remember when Warren Buffett — a staunch Obama supporter — said that rich people like him would be willing to pay more taxes to help out? If you do, it will probably shock you that his company, Berkshire Hathaway, has back taxes dating back to 2002.
The New York Post explains:
That's right: As Americans for Limited Government President Bill Wilson notes, the company openly admits that it owes back taxes since as long ago as 2002.
"We anticipate that we will resolve all adjustments proposed by the US Internal Revenue Service ("IRS") for the 2002 through 2004 tax years … within the next 12 months," the firm's annual report says.
It also cites outstanding tax issues for 2005 through 2009.
Obvious question: If Buffett really thinks he and his "mega-rich friends" should pay higher taxes, why doesn't his firm fork over what it already owes under current rates?
Likely answer: He cares more about shilling for President Obama — who's practically made socking "millionaires and billionaires" his re-election theme song — than about kicking in more himself.
Mogulite piles on:
Ironic, isn't it? When Warren Buffett penned that op-ed demanding he be taxed more, we assumed that meant he had actually paid his taxes. Not quite the case. Buffett's famed company, Berkshire Hathaway, owes taxes that are nearly a decade old.
[...] They promise they'll work it out with the IRS within the next year. Can't Buffett just take a little out of his piggy bank and pay up? For a man who so actively preaches honesty and integrity, we're a little baffled as to why Berkshire won't just fork over what it owes.
Earlier this month, Buffett penned a New York Times op-ed calling for increased taxes on the wealthy and even titled it "Stop codling the super-rich:"
While the poor and middle class fight for us in Afghanistan, and while most Americans struggle to make ends meet, we mega-rich continue to get our extraordinary tax breaks. Some of us are investment managers who earn billions from our daily labors but are allowed to classify our income as "carried interest," thereby getting a bargain 15 percent tax rate. Others own stock index futures for 10 minutes and have 60 percent of their gain taxed at 15 percent, as if they'd been long-term investors.
And as The Blaze pointed out when that op-ed was published, this has long been a rallying cry for Buffett.
Consider this 2007 interview he gave to Tom Brokaw:
So maybe it's no wonder that the Post concludes Buffet and others such as Obama are "disingenuous."
"That's clear from their individual behavior: Obama, Buffett and Democrats like Bill Clinton keep saying they want to pay more taxes," the article says. "Fine. They can always write checks."
Read the original article on The Blaze. Copyright 2011. Follow The Blaze on Twitter.


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Apathy and long-time collaborator Celph Titled may have kept hip-hop's underground scene in rugged shape for years now, but the pair provide some soundtrack material for the back-to-school slug this month with "School For Scoundrels." The Army of the Pharoahs MCs connect seamlessly over a neck-snapping beat, courtesy of Ayatollah.
This track will feature on Coalmine Records' upcoming compilation album, Unearthed, which will also feature vocal contributions from the likes of Pharoahe Monch, Kool G. Rap, Blu, Royce Da 5'9" and Large Professor, with beats coming from Nottz, Khrysis, M-Phazes and more.
Unearthed is scheduled for a second quarter release in 2013. Stream "School For Scoundrels" below, and purchase the song over on iTunes.
Colin Munroe - 'Unsung Hero' (Mixtape) | Die Antwoord "Dis Iz Why I'm Hot" (Zef Remix) (Video) |


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18th August 2013, 09:40 PM | #1 |
diyAudio Member
Join Date: Jun 2013
A silly question about sampling ...
Is the process of audio sampling a->d deterministic ? In other words if I play a vaw for example out from my dac and then acquire the analog out with a analog to digital converter more and more times, the file obtained are bit to bit identical ?
I think not, so i am curios about how different could be, even if I do not know nere and now a tools to compare the difference; perhaps the conversion can be made in wav so a proper audio tools can extract the diff. I ammon holidays without tools to inspect ... but curiosity is high ... I apologize for my bad english and for the silly question, I am searching a tools to inspect the difference between different digital source ... Mauro |
18th August 2013, 09:59 PM | #2 |
just another
diyAudio Moderator
Hi Mauro, if you do a D/A conversion and then A/D then yes each time you do it you will be altering the signal from the original. If you do it multiple times the error will compound.
I've not tried it but have seen it mentioned here a number of times. but audio diffmaker seems to be what you are after. Audio DiffMaker Tony.
Any intelligence I may appear to have is purely artificial! planet10 needs your help: Let's help Ruth and Dave |
18th August 2013, 10:05 PM | #3 |
diyAudio Member
In theory, all versions of the file would be identical. In practice, they would all be different. Subsequent A to D conversions would include what ever noise was present in the analog domain. The D to A conversions would, most likely, have added dither, which is digital noise. So, each generation would have additional noise.
18th August 2013, 11:07 PM | #4 |
diyAudio Member
Join Date: Mar 2012
Location: Bradford
Mauro, I think you might have misapplied your concept of determinism and presented yourself with a false dichotomy.
Could you explain what you mean by "deterministic", please, and how you distinguish it from "precise"? |
18th August 2013, 11:21 PM | #6 |
diyAudio Member
Join Date: Feb 2003
Location: ..
no analog channel is "deterministic" if you mean noise free
you may be thinking about what some call "generation loss" - put a signal thru some number of record/measure/playback/rerecord.. cycles and see how the signal changes any purely analog scenario - say studio tape recorder, EQ, lacquer cutting, needle drop, preamp with inverse EQ back to tape... chain is going to be laughably worse than most motherboard digital audio chipsets but even really good audio ADC/DAC aren't going to give bit perfect loopback because of gains, scale factors, offsets, filters all have tolerances orders of magnitude worse than even 16 lsb resolution Last edited by jcx; 18th August 2013 at 11:25 PM. |
18th August 2013, 11:31 PM | #7 |
diyAudio Member
Join Date: Feb 2009
Location: UK
In practice you will almost certainly not get a bit perfect copy, but... it could be arranged for you to do so, especially if the ADC and DAC were of low resolution and synchronised in their timing.
Some of the earliest computer memories were based on continuous recirculation of acoustic pulses in delay lines and relied on the pulses being received at one end and re-transmitted at the other, effectively by a 1-bit ADC and DAC, so a 'bit perfect' copy was essential. Delay line memory - Wikipedia, the free encyclopedia |
18th August 2013, 11:57 PM | #8 |
diyAudio Member
Join Date: Jul 2002
Location: Germany
Also shocking how good digital really works is this insane 60 generations D/A -> A/D conversion.
Zmix Converter Tests If you listened and think about it you may have another view about what is really important...
If time permits - stuff some parsley in your ears and listen how it grows! |
19th August 2013, 08:13 AM | #9 |
diyAudio Member
Join Date: Jun 2013
Well ...
Thanks to all for the reply ...
wintermute Audio DiffMaker is the tool I am searching for ... I will experiment with this ... PlasticIsGood I do not know the exact English meanigs of "deterministic", I have directly translate the word that in Italian I use in math/phys way ... "a finite system with well known initial state and subsequent state transformation ..." In my case the same wav file, the same hardware, the same (more or less) condition (temperature, supply voltage, rf noise ... etc ...); if the system is deterministic the result file must be identical bit to bit ... Is obvious that the the condition do not be costant so there will be different result but I want to investigate HOW different can be ... non from a infomatical prospective (two file with 1 bit different are completelly different) but from an psychoacoustics prospective ... I need to compare a lot of source chain with the "absolute ear" of a friend but I cannot test every change made with live a/b/x test with him (for logistics evident problems ...) So I am trying to reconvert ALL the test in digital from analog an submit all the digital result to him in a simple a/b/x test ... I am curios to compare what he can "ear" with instrumental relevated difference ... I will pass the Audio DiffMaker to an FFT analysis to compare the human hearing response with the instrumental perspective of the same difference ... if all is not the noise level of course The unique other way is remain in analog but I have to transport to my workshop one of a very BIG high quality tape recorder that we own ... but is a complete different story |
19th August 2013, 08:48 AM | #10 |
diyAudio Member
Join Date: Feb 2009
Location: UK
What are we meaning by bit perfect? The thing is that a perfectly sampled copy of a waveform but with an arbitrary delay will not be bit perfect when you look at the two files i.e. the numbers in the two files will be completely different - and I don't mean simply not aligned. However, the delay could be removed in software to get you back to a bit perfect copy (or almost).
This is a great video explaining how 'bit perfect' similarity between digital recordings is not likely to be achieved, but nor is it important in determining the quality of your copy. Xiph.Org Video Presentations: Digital Show & Tell |
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Position : OnBase DeveloperLocation : Richmond, VADuration : 12 Months PlusOnBase Developer/ system administrator implementing and supporting imaging, workflow, work view and various other OnBase related technologies. Programming & custom scripting desired.
Skills should include:-
1...VB scripting (desired)2...HTML knowledge (desired)3...OnBase E-form development4....Windows Server administration5....OnBase ECM product knowledge (OnBase certification preferred)
Ability to provide expertise in developing ECM applications and automated solutions.
Ability to resolve technical defects and respond to technical inquiries
Ability to create and/or provide input to create comprehensive workflow designs within the ECM system including definition of requirements, system design (general and detailed), application development, testing, training, and implementation.Plans include detailed Work Breakdown Structures and target start/end dates, estimated hours, necessary resources, task dependencies, milestones, etc.
Ability to work with others establishing & facilitating meetings. Helps to identify meeting objectives, plans agendas, and ensures ground rules are maintained, meeting objectives are met, and minutes are documented.
Ability to conduct timely and thorough technical research and analysis of specialized technical applications, products, and tools.
Ability to participate in work sessions to gather business and technical requirements.
Ability to design internal solutions and external system interface mechanisms, including appropriate application of techniques and standards such as service-oriented architecture, web services, etc.
Ability to develop conceptual system designs and implement strategies utilizing specialized applications, products, and tools
Ability to perform highly complex technical development, configuration, implementation, and support tasks including programming, testing and maintenance of specialized applications, solutions and products (such as, Document Imaging, Automated Workflow, e-Forms, Automated Correspondence, Business Rules Management, etc.)
Ability to ensure all programming and configuration work is functional with no unexpected results encountered to prepare for integration and acceptance testing.


text:
Abt Card
Product Questions - Ask
Average Customer Reviews
The Targus 4-Port USB 3.0 SuperSpeed Hub features the new and powerful SuperSpeed interface technology that revolutionizes the way we move data from devices to computers. Access data and transfer files up to 5GBps, copy large amounts of video, movies, music, photos, and data at lightning fast speeds. Compatible with PC, Mac, and Netbooks, this ultra powerful hub allows for easy connection from the hub to your USB enabled computer with a 5- foot cable. Ideal for connecting hard drives, docking stations, mice, flash drives, iPod/MP3 players and more. The hub includes a 4A AC adapter for when additional power is needed. The compact design makes it easy and convenient for travel without sacrificing its functionality.
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Make sure to get a powered USB hub
By Jim
from San Francisco
About Me High bandwidth user
Best Uses
Comments about Targus USB 3.0 Black 4-Port SuperSpeed Hub:
This hub works way better than an unpowered USB cable with just a bunch of connectors. It has a shape where there are connectors on both sides of the device which saves a bit of space compared to the ones where all the ports are on one side.I would have given it 5 stars but it won't charge my USB rechargeable bike light. So it doesn't work exactly like the USB port on my Mac. But it does power my webcam, wireless dongle for mouse, and USB headset just fine.
Fill out the form below to request Better Price for this product.


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I find sitting meditation helps focus my mind for later daily events. But everyone has unimportant distractions. I was taught to let them pass through the mind like clouds drifting by a window, sort of noted but not the focus of attention. Attention to the task at hand can be difficult for us all.
I am thinking of this, and what your words refer to. I find it difficult to find my inner peace back at the moment, and to install such rituals that would reintroduce the state of mind. Even when I enjoy fully a fragrance, a view of nature or the cuddly silence of my cat. Am I distracted ?
You are so very welcome Laureline. Enjoyment of moments such as those are ours for the picking. They are what we were designed to enjoy. But it seems most of us are in such a constant state of distraction we miss the mark.
Bonjour Ken, I really love what you wrote on Asaskian's thread "Perfumistes ..". Thank you for that.


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Orson Welles' camera, other items up for auction
03/31/2014 1:31am
The youngest daughter of director and writer Orson Welles is giving film buffs a chance to buy some of his personal possessions, including a camera, scripts and photos from the set of "Citizen Kane."
Imprisoned Uighur scholar receives literary honor
03/31/2014 9:20am
Ilham Tohti, the economist and activist imprisoned by Chinese authorities, has been awarded a Freedom to Write Award by the PEN American Center.
National Civil Rights Museum in Memphis reopening
03/31/2014 10:03am
One of the first exhibits visitors see at the newly renovated National Civil Rights Museum in Memphis displays statues of shackled and branded black men, sitting in a line with knees near their chins, on the deck of a creaking slave ship headed across an ocean.
Works of Virginia Woolf inspire London ballet
03/31/2014 10:11am
Many readers find Virginia Woolf's books moving. So does choreographer Wayne McGgegor, who is turning them into a ballet for Britain's Royal Opera House.
Hockey great Gordie Howe releasing book in October
03/31/2014 10:31am
Hockey great Gordie Howe has a book deal.
Nicole Richie bringing popular Web series to VH1
03/31/2014 11:21am
Nicole Richie's Twitter feed has launched her return to television.
Nephew claims self-defense in rapper's shooting
03/31/2014 11:41am
The nephew charged with shooting hip-hop artist and reality TV star Benzino during a weekend funeral procession on a Boston-area highway acted in self-defense, his lawyer said Monday.
Story of Benedict Arnold's wife may go to film, TV
03/31/2014 1:01pm
The story of Benedict Arnold's wife as depicted in a best-selling novel by the daughter of former New York Gov. George Pataki may be headed to the big and small screens.
Germany returns looted Guardi painting to Poland
03/31/2014 1:41pm
An 18th-century painting looted by the Nazis for Adolf Hitler's 'Fuehrer Museum' was handed back to Poland on Monday, a move Germany hopes will revive thorny talks over a vast trove of historical documents that Berlin wants to recover from Poland.
Pharrell Williams named as coach on 'The Voice'
03/31/2014 2:11pm
NBC has signed singer-songwriter Pharrell Williams as a coach for the upcoming seventh season of its musical competition series "The Voice."
'Noah' journeys to top of box office with $43.7M
03/31/2014 2:31pm
"Noah" smoothly sailed into the top spot at the weekend box office.
Shirley Jones postpones 80th birthday skydive
03/31/2014 3:01pm
Actress Shirley Jones is celebrating her 80th birthday on the ground, instead of skydiving as she had planned.
Steinem, Keys named honorees of annual DVF awards
03/31/2014 4:33pm
Designer Diane von Furstenberg, who made fashion news this year with the 40th anniversary of her famous wrap dress, is honoring an icon of the women's movement: Gloria Steinem.
New music coming from Michael Jackson estate
03/31/2014 4:50pm
A new posthumous album of previously unreleased Michael Jackson music comes out May 13.
Nine Inch Nails' Trent Reznor feels 'fresh start'
03/31/2014 5:21pm
Trent Reznor says he feels "a fresh new start" for Nine Inch Nails after the band's latest album and world tour.
Actress Sara Gilbert and musician Linda Perry wed
03/31/2014 5:30pm
Sara Gilbert and Linda Perry are married.
Review: 'Heathers: The Musical' shallow but catchy
03/31/2014 6:20pm
All of the fantastically mixed-up characters in "Heathers: The Musical" seem plagued by the show's timeless catch phrase, a telling rhetorical question: "What's your damage?"
Oprah's former stepmother gets 60 days to vacate
03/31/2014 8:31pm
Oprah Winfrey's former stepmother has been given extra time to vacate the $1.4 million home she once shared with the father of the iconic talk-show host.
CBS comedy 'How I Met Your Mother' ends
03/31/2014 8:41pm
In its 208th and final episode on Monday, the CBS comedy "How I Met Your Mother" finally revealed the mystery contained in its title and then ended with a twist designed to reward longtime fans.
Sheriff: Man broke into Selena Gomez guesthouse
03/31/2014 8:42pm
Authorities say they've arrested a man who's accused of breaking into Selena Gomez's guesthouse while the 21-year-old actress and singer was home.
Engaged Johnny Depp shows off 'chick's ring'
03/31/2014 9:51pm
Johnny Depp showed off a diamond engagement ring that he called a "chick's ring" on Monday — indirectly confirming rumors of his engagement to actress Amber Heard.
Mexico honors Octavio Paz 100 years after birth
03/31/2014 10:31pm
Mexicans honored Nobel Prize poet and essayist Octavio Paz on Monday, marking the 100th anniversary of the late writer's birth.