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Spanish Ebola patient gets experimental drug
Photo Credit: Shutterstock
MADRID (AP) — In a development that raises a host of ethical issues, Spain announced it had obtained a scarce U.S.-made experimental Ebola drug to treat a Spanish missionary priest infected with the killer virus.
The Health Ministry statement came less than a week after the U.S. Centers for Disease Control and Prevention said there were virtually no doses available of the drug that was used to treat two Americans with the disease.
The drug's maker, Mapp Pharmaceutical Inc. of San Diego, says "very little of the drug is currently available" and that is cooperating with government agencies to increase production as quickly as possible.
Nigerian officials say they had asked U.S. health authorities about getting the Ebola drug but were apparently not helped.
There is no known cure or licensed treatment for Ebola, which has killed over 960 people in the current outbreak in West Africa. The World Health Organization has called the Ebola outbreak — which emerged in Guinea in March and has since spread to Liberia, Sierra Leone and possibly Nigeria — an international health emergency and urged nations worldwide to battle the disease.
The ethical questions surrounding experimental Ebola drugs and vaccines were being debated Monday during a teleconference of medical ethicists and other experts organized by the U.N. health agency.
In a statement provided Monday, the Spanish Health Ministry said the ZMapp drug was obtained in Geneva this weekend with permission from the company and brought to Madrid to treat Miguel Pajares.
The 75-year-old priest was evacuated from Liberia and placed in isolation Thursday at Madrid's Carlos III Hospital.
Two Americans diagnosed with Ebola in Liberia and evacuated back to the United States have been treated with the drug. One of them, Dr. Kent Brantly, said last week that his condition was improving and the husband of the aid worker being treated with Brantly said the same thing. Both are in isolation at an Atlanta hospital.
It was not exactly clear how Spain got the drug.
Spain said it obtained permission from the laboratory developing the drug and, under an agreement between WHO and the Doctors Without Borders charity group, imported the drug from Geneva where it said a dose had been available. The ministry said Spain sought the drug under legislation permitting use of unauthorized medication in patients suffering from a life-threatening illness who cannot be treated satisfactorily with any authorized drug.
WHO spokesman Gregory Hartl, however, told The Associated Press on Monday that the U.N. agency had no role in helping Spain obtain the experimental drug.
At least one country in West Africa has expressed interest in the Ebola drug. Nigeria's health minister, Onyenbuchi Chukwu, said last week he had asked U.S. health officials about access but was told the manufacturer would have to agree.
Dr. Tom Frieden, director of the U.S. Centers for Disease Control and Prevention, said "there are virtually no doses available," a CDC spokesman said last week.
Because the ZMapp drug has never been tested in humans, scientists say there's no way to tell if it has made any difference to the two American aid workers who have received it.
The drug is a mixture of three antibodies engineered to recognize Ebola and bind to infected cells so the immune system can kill them. Scientists culled antibodies from laboratory mice and ZMapp's maker now grows the antibodies in tobacco plants and then purifies them. It takes several months to even produce a modest amount of the drug.
In other Ebola developments:
— Nigerian health authorities confirmed another Ebola case Monday, a nurse who was treating Patrick Sawyer, the Liberian-American who flew into Nigeria with the disease and died of it last month. That brings the locally confirmed Ebola cases in Nigeria to 10, including two who have died, Sawyer and another nurse. Nigerian authorities now have 177 contacts of Sawyer under surveillance. WHO has not yet confirmed the Ebola cases in Nigeria.
— The hemorrhagic disease is ravaging some of the world's poorest countries, and their ill-equipped health systems have struggled to keep up. Liberia announced that a donation of protective gear from China was arriving Monday. A shortage of full-body suits and even clean surgical gloves has left health workers exposed to the virus and prompted some to refuse to treat Ebola patients.
— Residents in central Liberia rioted over the weekend, claiming the government had left some highly infectious bodies of Ebola victims in the streets for days without picking them up.
— George Weah, a former FIFA world player of the year from Liberia, has joined the efforts to spread awareness about the disease and how to prevent it. He recording a song titled "Ebola is real," and proceeds are going to the Liberian Health Ministry.
(Copyright 2014 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.)
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Rainy Day Women was played by Jerry Garcia with Bob Dylan during the Dylan set on June 25, 1995, at RFK Stadium, Washington.
The song was first recorded by Dylan on March 10, 1966. A working title for the song used during recording sessions is reported to have been A Long Haired Mule And A Porcupine. The single reached number 2 in the US pop charts.
Blonde On Blonde, 1966 Single (Rainy Day Women # 12 & 35 / Pledging My Time), 1966 Bob Dylan's Greatest Hits, 1967 Before the Flood, 1974 Masterpieces, 1978 Rude Awakening Soundtrack, Various Artists, 1989 Rock Classics Of The 60s, 1990 Bob Dylan 30th Anniversary Concert Celebration, Various Artists, 1993 Forrest Gump Soundtrack, Various Artists, 1994 Unplugged, 1995 The First Summer of Love: 45 Classic Hits From the Sixties, Various Artists, 1997 The Essential Bob Dylan, 2000 The Very Best Of, Bob Dylan, 2000 Best Of Bob Dylan, Volume 2, 2000 Blonde on Blonde/Blood on the Tracks/Time Out of Mind, 2001 Bringing It All Back Home/Highway 61 Revisited/Blonde on Blonde, 2001 Ultimate Jukebox Hits of the 60's, Vol 3, Various Artists, 2002 Jukebox Hits of the 60's, Various Artists, 2002 40 Years Of Jukebox Hits, Various Artists, 2002 Q: Bob Dylan, Vol 2: Blonde on Blonde/Blood on the Tracks/Basement Tapes, 2002 Greatest Hits, Vol. 1-3, 2003 Best Of Bob Dylan, 2005 Collection Vol. 3: Blonde on Blonde/Blood on the Tracks/Infidels, 2005 Dylan, 2007 (single CD) Dylan, 2007 (3 CD) Essential Bob Dylan Limited Edition 3.0, Bob Dylan, 2009 Pure... Psychedelic Rock, Various Artists, 2011 Music & Photos, Bob Dylan, 2013
Moldy Goldies, Colonel Jubilation B. Johnston and His Mystic Knights Band and Street Singers Attack The Hits, 1966 The Baroque Inevitable, John Simon, 1966 The Immortal Songs Of Bob Dylan, Gotham String Quartet, 1966 Single (Rainy Day Women #12 & 35 / When A man Loves A Woman), Bobby Brooks / Leroy Jones, 1966 Light My Fire, Bob Thiele and his New Happy Times Orchestra w/ Gabor Szabo, 1967 Portrait Of Bob Dylan, The Fontana Concert Orchestra, 1968 Nashville Airplane, Earl Scruggs, 1969 Keep Your Eye On The Sparrow, Merry Clayton, 1975 The Times They Are A Changin': A Tribute To Bob Dylan, Vol 1, Various Artists (David Harris), 1991 1964-1969, Plus, Flatt & Scruggs, 1992 Outlaw Blues, Vol. 2, Various Artists (Dodgy), 1992 Marijuana's Greatest Hits Revisited, Various Artists (Subtle Plague), 1993 Tense It Up!, Various Artists (Subtle Plague), 1994 Flynn's Place, Little Mike and the Tornadoes, 1995 Pucker!, The Selecter, 1995 Hairspray, The Selecter, 1995 Hempilation: Freedom is Normal, Various Artists (Black Crowes), 1995 Doin' Dylan, Various Artists (Black Crowes), 1996 Come, Lily, Come, Lily, 1998 Flatt On Victor Plus More, Lester Flatt, 1999 Burning Love, Afire, 1999 Earl Scruggs: His Family and Friends / Nashville Airplane, Flatt & Scruggs, 2000 Duluth Does Dylan, Various Artists (Black Labels), 2000 Live and Loud at the Wormy Dog, Cross Canadian Ragweed, 2001 Blues on Blonde on Blonde, Various Artists (Brian Stoltz), 2003 The Long Road to Cabo (DVD), Sammy Hagar & The Waboritas, 2003 Masters of Dylan, Highway 61 Revisited, 2004 Mostly Dylan, Tom Corwin & Tim Hockenberry, 2004 Foggy Mountain Breakdown, Flatt & Scruggs, 2004 A Musical History, The Band, 2005 Listen to Bob Dylan: A Tribute Album, Various Artists (Rock 'N' Roll Soldiers), 2005 O Brother, I'm Here, Mr. David Booker, 2005 Out of the Ashes, Jessi Colter, 2006 Late in the Night, Rick Holmstrom, 2007 Up All Night Live, Brian Stoltz, 2007 Circus Roncalli Royal Orchestra, Circus Roncalli Royal Orchestra, 2007 Meet the Crocuses, American Wicker, 2007 Dylan Project/Live at Cropredy Festival 1999, Steve Gibbons/The Dylan Project, 2008 The Broadcast Archives (DVD), Tom Petty, 2008 Dylan Different, Ben Sidran, 2009 Chimes Of Freedom: The Songs Of Bob Dylan, Various Artists (Lenny Kravitz), 2012 8/22/14,ĀSan Rafael, CA, Anders Osborne, 2014

subset: commoncrawl


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Thursday is Thanksgiving and I have a lot to be thankful for this year.
You, my readers, are one of the reasons for which I'm thankful. As the year comes to a close I think of all the kind words that have come my way from you. I think of all the questions and answers, all the stories shared and all the smiles exchanged. Along with a few seeds. You keep me on my toes and I thank you.
If you currently subscribe or have subscribed in the past to the Anderson News, then simply find your account number on your mailing label and enter it below.
Click the question mark below to see where your account ID appears on your mailing label.
If you are new to the award winning Anderson News and wish to get a subscription or simply gain access to our online content then please enter your ZIP code below and continue to setup your account.
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Created 10 years ago as part of the Medicare Prescription Drug and Modernization Act of 2003, health savings accounts (HSAs) have gained in popularity over the past decade. According to the Employee Benefit Research Institute (EBRI), more employers and employees have been contributing to HSAs in recent years, and the amount contributed to HSAs has generally been on the rise.
For example, the percentage of individuals in employee-only HSAs contributing $1,500 or more rose from 21% in 2006 to 42% in 2012, while the percentage of employees contributing nothing decreased from 28% to 15% over that same period. (Sources: "HRA/HSA Health Plan Contributions Continue to Grow," EBRI, February 20, 2013, and EBRI Notes, February 2013.) If you are eligible to contribute to an HSA, you may want to take another look at these savings plans, which could benefit your financial situation both now and in the future.
HSAs explained
Health savings accounts help individuals and families set aside money on a tax-advantaged basis to pay for health-care costs. HSAs are typically offered by employers along with what's known as "high-deductible health plans," or HDHPs–health insurance plans that generally offer lower premium payments in exchange for high annual deductibles (at least $1,250 for individuals and $2,500 for families in 2013).* You must be enrolled in an HDHP in order to participate in an HSA. If your employer provides an HDHP but does not offer an HSA, you may be able to establish an account on your own through a financial institution. Self-employed individuals can also use HSAs.
Here's how an HSA works:
— You can contribute up to $3,250 for individual coverage or $6,450 for family coverage to an HSA in 2013. If you are age 55 or older, you may also make "catch-up" contributions of up to $1,000.
— Your employer may also make contributions on your behalf.
— You can contribute in one lump sum or in periodic (e.g., monthly) amounts.
— You can make contributions for the current year up until your tax-filing deadline (generally, April 15 of the year following the year of coverage).
One of the key advantages of an HSA is that your contributions are tax deductible. If your plan is offered through your employer, you may be able to make automatic contributions on a pretax basis (similar to a work-based retirement savings plan) and any employer contributions are generally excluded from your gross taxable income as well. Moreover, you can typically select from a variety of savings and investment vehicles for your contribution dollars, and the earnings grow tax deferred until you withdraw them. Withdrawals then used for qualified medical expenses are tax free.
Permitted expenses
You can withdraw money from your HSA to pay for qualified expenses for yourself, your spouse, or your dependents. Permitted expenses include:
— Health insurance deductibles and co-payments
— Prescription drugs
— Vision care and eyeglasses
— Dental care
— Laboratory fees
— Hearing aids and more
For a complete list of eligible expenses, please see IRS Publication 502.
On the other hand, HSA distributions that you use for nonqualified expenses are subject to income taxes and a 20% penalty tax.
Eligibility rules
In order to be eligible for an HSA, you must have qualifying HDHP coverage. You won't be eligible if you're covered by another health plan (e.g., your spouse's nonqualified health plan), if you're 65 and enrolled in Medicare, or if someone else can claim you as a dependent. In addition, you may be ineligible if you're covered under a flexible spending account or health reimbursement arrangement that offers coverage similar to the HSA's.
Plans that won't affect your eligibility include dental and vision care insurance, long-term care insurance, and disability and accident insurance.
Unlike flexible spending accounts, where you have to use up all the funds you set aside for a plan year by a certain date or forfeit the money, HSA funds are yours to keep. If you leave your current employer and would like to roll your HSA money into another HSA, you are typically permitted to do so. And provided you are still eligible, you can continue to save in your account on a tax-deferred basis until you enroll in Medicare.
*Total out-of-pocket costs for HDHPs cannot exceed $6,250 for individuals and $12,500 for families.
The opinions voiced in this material are for general information only and are not intended to provide specific advice or recommendations for any individual. To determine which investment(s) may be appropriate for you, consult your financial advisor prior to investing. All performance referenced is historical and is no guarantee of future results. All indices are unmanaged and cannot be invested into directly. The tax information provided is not intended to be a substitute for specific individualized tax planning advice. We suggest that you consult with a qualified tax advisor.
Prepared by Broadridge Investor Communication Solutions, Inc. Copyright 2013


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good to hear..live and learn..
That I was wrong. Naps DID come through.
I had already given up on naps and went with another local source for some gear (of which will be gone in a couple weeks), but yesterday I got one of those "we missed you, your package is now at the post office" letters.
I had ordered a book a few days ago so I just expected it to be that. Well, needless to say, I was more than surprised to find that it was my "missing" package!
My PCT didn't come with it, but that stuff is cheap and much more easily gotten than test prop or mast. So I am very very happy. It did take 5 and 1/2 months, but I am now eating my words.
Glad to see others are getting their packs in as well. I haven't been around here much lately (got tired of always worrying about when/if this shit would come in haha). But to GXR and Anabolic, THANKS! And sorry for being an ass sometimes. Naps is good to go, and I can't wait to start sticking myself with some Geneza product here in a few weeks
good to hear..live and learn..
Glad your stuff came Bro, open a ticket on the missing items and lets get those out to you too.
Another pack received, good deal
Lot's of packs showing up, still a few more for those that are waiting patiently and then we will all be happy.


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Banning The Big Idea Book Club
Kathryn Schulz isn't against having big ideas, or writing about them. But she's not a fan of "The Big Idea Book Club," she writes, in New York magazine.
The club, she says,
is a recent phenomenon. Its accidental founder and president in apparent perpetuity is Malcolm Gladwell. Its membership, like the membership of most powerful groups, is largely male. Its combined sales are stratospheric; whatever these books are hawking, we can't stop buying it.
As for the books themselves, I'll generalize (as, often, do they). Big Idea tomes typically pull promiscuously from behavioral economics, cognitive science, and evolutionary psychology. They coin phrases the way Zimbabwe prints bills. They relish upending conventional wisdom: Not thinking becomes thinking, everything bad turns out to be good …
What irks me most about this infinite parade of gigundo solutions isn't their glibness or even the borderline theology (of some) and borderline Babbitry (of others) involved in promising audiences easy, happy, profitable ideas. Nope. What irks me is that when you rigidly apply grand theories to everybody, sooner or later everybody feels like nobody, whether you're in Communist Belgrade or the local DMV. There is a reason we call such systems soul-crushing: They ignore or annihilate individual difference and inner life.


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A Moderate Christian Response to the Gun Debate
We talked about gun control on my radio show yesterday. Thought some of you might appreciate the perspective. Live from Seattle with Doug Bursch airs daily from 4-6 pm on 820 AM KGNW. Streams live at kgnw.com. Click below for yesterday's show


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Belinostat and Azacitidine in Treating Patients With Advanced Hematologic Cancers or Other Diseases
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- How to Read a Study Record
Condition | Intervention | Phase |
Accelerated Phase of Disease Adult Acute Myeloid Leukemia With Inv(16)(p13.1q22); CBFB-MYH11 Adult Acute Myeloid Leukemia With t(16;16)(p13.1;q22); CBFB-MYH11 Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); RUNX1-RUNX1T1 Adult Acute Myeloid Leukemia With t(9;11)(p22;q23); MLLT3-MLL Adult Acute Promyelocytic Leukemia With t(15;17)(q22;q12); PML-RARA Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative Blastic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive Chronic Myelomonocytic Leukemia de Novo Myelodysplastic Syndrome Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable Philadelphia Chromosome Negative, BCR-ABL1 Positive Chronic Myelogenous Leukemia Previously Treated Myelodysplastic Syndrome Primary Myelofibrosis Recurrent Adult Acute Lymphoblastic Leukemia Recurrent Adult Acute Myeloid Leukemia Recurrent Disease Secondary Acute Myeloid Leukemia Secondary Myelodysplastic Syndrome |
Drug: Belinostat Drug: Azacitidine Other: Laboratory Biomarker Analysis |
Phase 1 |
Study Type: | Interventional |
Study Design: | Allocation: Randomized Intervention Model: Parallel Assignment Masking: Open Label Primary Purpose: Treatment |
Official Title: | A Phase I Study of PXD101 in Combination With Azacitidine (5-Aza) for Advanced Hematologic Malignancies |
- Maximum tolerated dose of belinostat in combination with azacitidine [ Time Frame: Course 1 (28 days) ]Graded using the National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) version 3.0 or 4.0.
- Changes in pharmacodynamic variables (target gene expression, apoptosis) [ Time Frame: Course 1 (baseline to day 5) ]Compared between the two groups using two-sample t tests.
- Association of methylation status, categorized as positive or negative, with changes in target gene expression [ Time Frame: Baseline, days 4 or 5, and days 25-28 ]Distinguished by sequence-specific polymerase chain reaction (PCR) primers. Compared using a two-sample t or Wilcoxon nonparametric test.
- Clinical activity (complete remission, partial remission, stable disease, hematologic improvement) [ Time Frame: After 4, 8, and 16 weeks ]Recorded and tabulated for both the MTD and randomized cohorts.
Enrollment: | 56 |
Study Start Date: | June 2006 |
Study Completion Date: | March 2013 |
Primary Completion Date: | March 2013 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
Experimental: Arm I (chemotherapy)
Patients receive azacitidine SC on days 1-5.
Drug: Azacitidine
Given SC
Other Names:
Other: Laboratory Biomarker Analysis
Correlative studies
Experimental: Arm II (chemotherapy, enzyme inhibitor therapy)
Patients receive azacitidine as in arm I and belinostat at the MTD IV over 30 minutes on days 1-5.
Drug: Belinostat
Given IV
Other Names:
Drug: Azacitidine
Given SC
Other Names:
Other: Laboratory Biomarker Analysis
Correlative studies
Detailed Description:
I. Determine the maximum tolerated dose of PXD101 (belinostat) when given in combination with azacitidine (when azacitidine is utilized at a dose range where its effects on cellular differentiation are known to be predominant) in patients with advanced hematologic cancers or other diseases.
I. Identify any additive or synergistic effects of this regimen on pharmacodynamic parameters, including apoptosis and re-expression of specific target genes.
II. Assess any evidence of clinical activity (complete remission, partial remission, hematologic improvement, stable disease) of this regimen in these patients.
OUTLINE: This is a dose-escalation study of belinostat followed by a randomized study.
Patients receive azacitidine subcutaneously (SC) and belinostat intravenously (IV) over 30 minutes on days 1-5. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity. Cohorts of 3-6 patients receive escalating doses of belinostat until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which 2 of 6 patients experience dose-limiting toxicity. After the MTD is determined, additional patients with myelodysplastic syndromes (MDS) or acute myeloid leukemia (with trilineage dysplasia or arising from MDS) are randomized to 1 of 2 treatment arms.
Arm I: Patients receive azacitidine SC on days 1-5.
Arm II: Patients receive azacitidine as in arm I and belinostat at the MTD IV over 30 minutes on days 1-5.
In both arms, courses repeat every 28 days in the absence of disease progression or unacceptable toxicity. After receiving one course, patients randomized to arm I may crossover to receive treatment on arm II.
For patients enrolled in the randomized portion of the study, bone marrow aspirates are obtained at baseline, and after course 1 for correlative studies. Samples are examined by gene expression analysis of p15 and p21, DNA methylation of p15INK4B, and apoptosis by RT-PCR and flow cytometry. Pharmacodynamic assays are also performed.
After completion of study treatment, patients are followed periodically for up to 2 years.
Ages Eligible for Study: | 18 Years and older (Adult, Senior) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Histologically confirmed diagnosis of 1 of the following:
- Relapsed or refractory acute myeloid leukemia (AML)
- Relapsed or refractory acute promyelocytic leukemia (must have failed both tretinoin and arsenic trioxide)
- Relapsed or refractory acute lymphoblastic leukemia
- Secondary AML, including AML arising from antecedent hematologic diseases, such as myelodysplastic syndromes (MDS) or myeloproliferative disorders, OR therapy-related AML
- Chronic myelogenous leukemia in accelerated or blast phase
Advanced phases of Philadelphia chromosome-negative (Ph-) chronic myeloproliferative disorders, as defined by ≥ 1 of the following:
- Presence of anemia (hemoglobin < 10 g/dL and/or red blood cell transfusion dependent)
- Presence of palpable splenomegaly
MDS, including chronic myelomonocytic leukemia
- Must have intermediate or high-risk International Prognostic Scoring System (IPSS) scores (≥ 0.5)
Low-risk IPSS scores allowed provided ≥ 1 of the following criteria are met:
- Hemoglobin < 10 g/dL and/or red blood cell transfusion dependent
- Platelet count < 50,000/mm³
- Absolute neutrophil count < 1,000/mm³
- Refractory disease OR no standard therapy exists
- Evidence of AML associated with dysplasia on bone marrow histology for elderly patients (i.e., > 60 years old) who are previously untreated and not candidates for or unwilling to undergoing induction therapy
- No known active CNS involvement with disease
- CALGB performance status (PS) 0-2 OR Karnofsky PS 60-100%
- Bilirubin ≤ 2.0 mg/dL (unless due to Gilbert's syndrome)
- ALT ≤ 3 times upper limit of normal (unless due to disease)
- Creatinine ≤ 2 mg/dL
- Not pregnant or nursing
- Negative pregnancy test
- Fertile patients must use effective contraception
- No history of allergic reactions attributed to compounds of similar chemical or biologic composition to PXD101 or Azacitidine
- No history of allergic reactions to mannitol
- No history of dose-limiting toxicity during prior treatment with Azacitidine
No concurrent uncontrolled illness including, but not limited to, the following:
- Ongoing or active infection
- Symptomatic congestive heart failure
- Unstable angina pectoris
- Cardiac arrhythmia
- Psychiatric illness or social situation that would preclude compliance with study requirements
- No marked baseline prolongation of QT/QTc interval (e.g., repeated demonstration of a QTc interval > 500 msec)
- No long QT syndrome
No uncontrolled cardiovascular disease, including the following:
- Severe uncontrolled hypertension
- Uncontrolled congestive heart failure related to primary cardiac disease
- Uncontrolled cardiac arrhythmia
- Uncontrolled ischemic or severe valvular heart disease
- Myocardial infarction within the past 6 months
- See Disease Characteristics
- Recovered from prior therapy
- At least 2 weeks since prior chemotherapy (6 weeks for mitomycin C or nitrosoureas)
- At least 2 weeks since prior radiotherapy
- At least 4 weeks since prior investigational agents
- At least 24 hours since prior hydroxyurea
- At least 2 weeks since prior valproic acid
- No concurrent combination antiretroviral therapy for HIV-positive patients
- No other concurrent investigational agents
- No concurrent medication that may cause torsade de pointes
- No other concurrent anticancer therapy, including chemotherapy, radiotherapy, or biological agents
Please refer to this study by its ClinicalTrials.gov identifier: NCT00351975
United States, Illinois | |
University of Chicago Comprehensive Cancer Center | |
Chicago, Illinois, United States, 60637 | |
United States, Wisconsin | |
University of Wisconsin Hospital and Clinics | |
Madison, Wisconsin, United States, 53792 | |
Canada, Ontario | |
University Health Network-Princess Margaret Hospital | |
Toronto, Ontario, Canada, M5G 2M9 | |
New Zealand | |
Princess Margaret Hospital | |
Cashmere, Canterbury, New Zealand, 8022 |
Principal Investigator: | Olatoyosi Odenike | University of Chicago Comprehensive Cancer Center |
Responsible Party: | National Cancer Institute (NCI) |
ClinicalTrials.gov Identifier: | NCT00351975 History of Changes |
Obsolete Identifiers: | NCT00336804 |
Other Study ID Numbers: |
NCI-2009-00146 NCI-2009-00146 ( Registry Identifier: CTRP (Clinical Trial Reporting Program) ) UCCRC-14510A NCI-7285 CDR0000486418 14510A ( Other Identifier: University of Chicago Comprehensive Cancer Center ) 7285 ( Other Identifier: CTEP ) U01CA069852 ( US NIH Grant/Contract Award Number ) U01CA132123 ( US NIH Grant/Contract Award Number ) P30CA014599 ( US NIH Grant/Contract Award Number ) U01CA062491 ( US NIH Grant/Contract Award Number ) |
Study First Received: | July 13, 2006 |
Last Updated: | December 22, 2014 |
Additional relevant MeSH terms:
Syndrome Leukemia Myelodysplastic Syndromes Preleukemia Leukemia, Myeloid Leukemia, Myeloid, Acute Neoplasm Metastasis Precursor Cell Lymphoblastic Leukemia-Lymphoma Leukemia, Lymphoid Leukemia, Myelogenous, Chronic, BCR-ABL Positive Primary Myelofibrosis Myeloproliferative Disorders Philadelphia Chromosome Leukemia, Promyelocytic, Acute Leukemia, Myelomonocytic, Chronic |
Myelodysplastic-Myeloproliferative Diseases Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative Disease Pathologic Processes Neoplasms by Histologic Type Neoplasms Bone Marrow Diseases Hematologic Diseases Precancerous Conditions Neoplastic Processes Lymphoproliferative Disorders Lymphatic Diseases Immunoproliferative Disorders Immune System Diseases Translocation, Genetic |
ClinicalTrials.gov processed this record on March 27, 2017


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White Life is a pop group whose retro feel and soulful, heart-wrenching delivery offer up far more than standard pop fare. With slyly addictive beats, the tracks distill and articulate a profound and familiar longing (for summer, for love, for the future). These anthems will remind you what you adored about dance tracks the first time you heard them, and in your complete enchantment finally free you of the lurking fear that you won't hear as good again. Catchy and captivating, every hook on this glistening debut transports listeners to a youthful collective past and to the hidden recesses of that still untapped desire, while remaining fun, danceable, and -at first listen- blissfully carefree. -Ehse Records
Any questions, contact: ehserecords "at" gmail


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I wish he was talking about his teeth or hair but he is not... he is talking about brushing water onto his chalkboard.
I have him "paint" right on his chalkboard easel. It is great because the chalkboard dries off and he can keep creating new pictures without me having to change out the paper. And lets not forget that water is MUCH cleaner than paint!!
All you need is a paint brush and a cup of water. I put very little water in the cup, in case it gets tipped over (that way I only have a little water to clean up)
As you can see, he gets pretty serious about it!
If you do not have a chalkboard you can also use construction paper. You can let the papers dry off and reuse them again!
Brush away little man!


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Yesterday, I made the weekly call to my folks. They're recently retired and making the most of their abundant free time by going to the cinema more frequently. They had just seen both G.I. Joe and District 9, and are probably the only people on Earth who loved the former and hated the latter.
My theory is that they're becoming senile and got the films mixed up — they walked out of District 9 saying to each other, "Wow G.I. Joe was really great!" It's either that, or I must stop loving them.
This looks in no way enticing. Does it?
I know that I'll soon see (and enjoy) District 9, but I'm having an internal struggle with G.I. Joe. It's embarrassing that even a tiny slice of my brain is attracted to it. I mean, it was less than a month ago that I ignored my better instincts and decided to give the second Transformers film a shot. I left the theater shell-shocked and sickened at my own gullibility. How could I have let myself believe that it might be fun? Why wasn't I able to trust the critics, let alone this website which I spend every waking hour working on?!
And why am I similarly drawn to G.I. Joe? I know that it's going to be awful, and that I'm going to be mad at myself immediately after seeing it. Why should I reward a studio which churns out such junk with my money? Should I go with low expectations, hoping to at least have them met?
Laremy Legel has a great article at Film.com, explaining why it's okay to keep our expectations high and allow ourselves to hate G.I. Joe. I think I'm going to read it every day until I finally lose the desire to waste my money. Or… what do you think I should do?


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Tre Wilcox and Loft 610 owner to open new restaurant
This part you've heard. Former Top Chef contestant and Abacus alum Tre Wilcox (top left) takes the top spot at Plano's Loft 610 Urban Restaurant & Lounge on 10/06. (Fun with numbers: 10/06, 610)
What you haven't heard is that Loft 610 owner Brian Twomey (top right) is also backing Wilcox in the chef's first solo restaurant. The two have been scouting potential real estate in uptown, downtown and the Park Cities, but Twomey says to expect something "south of Northwest Highway" in 18 months or so.
The vision is for a chef-driven fine dining spot, probably to be called "Tre." Twomey, a business and marketing whiz whose credits include work with Citigroup and Coca-Cola, says that he and Wilcox (both in their thirties) gelled creatively right away.
For now though, Twomey says "our top priority is Loft 610."


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Choices supports habitat restoration
Choices Markets Surrey store manager, Mike Evans, hands a cheque for $278.47 to Friends of Semiahmoo Bay Society president Margaret Cuthbert and FoSBS volunteer David Riley.
Choices Markets served up more than hot dogs at a recent barbecue fundraiser in South Surrey.
The event, which raised nearly $300 for Friends of Semiahmoo Bay Society, is earmarked to support restoration of the Nicomekl River estuary, which is home to herring, sand lance and surf smelt.
FoSBS president Margaret Cuthbert said the boost "really makes a difference for us, for the educational programs."
For more on the society, visit www.birdsonthebay.ca
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Not evenyone.
Just Sanchez.
Sorry you're having such a bad offseason thus far brofist, with Ryan retained, a GM soon to be hired you already hate sight-unseen, Mods warning you to cut the schtick. Must be a tough time for SAR (see what I did there, I'm talking to you, but I reference you in third person, just like you do when discussing yourself, lol, funny ain't it!) right now.
You have a good day my friend.


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They've got muck; we've got rakes. TPM Muckraker
Debate Planners Can't Find Anyone to Argue That Health Reform Is Unconstitutional
Washington's attorney general, Rob McKenna, has joined 12 other state AGs on the lawsuit, filed last week, that argues the bill is unconstitutional. We took a look at the suit's slim chances of success here.


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Galaxy coach Arena suspended for 1 gameAP , Associated Press
Oct. 4, 2013 3:44 PM ET
NEW YORK (AP) — Los Angeles Galaxy coach Bruce Arena has been suspended for one game after going on the field during last Sunday's match against the Portland Timbers. Galaxy forward Robbie Keane appeared to score the equalizer early in stoppage time but he was called offsides. Both Keane and Landon Donovan had an animated argument with officials while Arena shouted from the sidelines. Arena also confronted the referees on the field after the match, which the Timbers won 1-0. The MLS Disciplinary Committee determined Arena left his technical area and entered the field of play, which results in an automatic one-game suspension under league policy. Arena will miss the Galaxy's match Sunday against Chivas USA. © The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed. Learn more about our Privacy Policy and Terms of Use. |


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(b) The procedures and curricula shall be developed in consultation with public and private agencies that provide programs for victims of domestic violence, advocates for victims, organizations representing the interests of shelters and personnel who have demonstrated expertise and experience in providing health care to victims of domestic violence and their children.
Note: WV Code updated with legislation passed through the 2016 Regular Session
The West Virginia Code Online is an unofficial copy of the annotated WV Code, provided as a convenience. It has NOT been edited for publication, and is not in any way official or authoritative.


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Take your hate for G&P and shove it - you've been bashing them for months. They are a good team and were undermarked here because they skated early in the night and have not been at the Worlds before. They skated much better than many of the teams that placed ahead of them. They are better than Chock & Bates and several of the others. G&P beat Chock & Bates in the FD at 4 Continents and have the potential to move up in the FD here too.
G&P will continue to advance in the standings down the road with more international experience.


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For reasons that extend beyond their music, the Doors remain an enduring part of popular culture.
The main reason, of course, is singer Jim Morrison, the Lizard King, a charter member of the better-to-burn-out-than-fade-away school of rock stardom. If you like Morrison and the Doors, you probably consider Morrison a rock poet. If you don't, you probably think he's a pretentious mess.
There is no question which side of the equation writer and director Tom DiCillo falls on. He made "When You're Strange," a documentary about the Doors that's reverential to a fault. He unearthed a lot of never-before-seen footage of Morrison and the band, and splices in bits of "HWY," an experimental film Morrison made in 1969 that consists mostly of him driving through the desert. Johnny Depp narrates DiCillo's script; there are no contemporary interviews. There are, however, stock shots of '60s footage portraying the youth movement and general unrest. In DiCillo's film, the Doors are at its center, providing its soundtrack, with Morrison the twisted shaman.
Or not. As Morrison descends from experimental drug use into alcohol abuse, DiCillo's footage chronicles the growing frustration of his bandmates, John Densmore, Robby Krieger and Ray Manzarek. Fans feel differently, feeding on Morrison's antics. Included here is footage from the Miami concert where Morrison was arrested for exposing himself (although no photographs of a well-photographed event exist of the specific incident), as well as Morrison wandering the crowd before another show. In the former he's out of his mind, drunk on power and pretense and who knows what else. In the latter, he's curious, affable, if somewhat distant. He was a different kind of guy, though that's not exactly news.
As far as anything revelatory, that and the "HWY" footage pretty much take care of it. Although Doors fans will drool over the prospect of the previously unseen footage, they are unlikely to find anything new here. DiCillo retells the Doors story even casual fans are familiar with, while Depp simply reads it. However you feel about the Doors, their career and their music, the one thing they weren't was straightforward.
Too bad "When You're Strange" is.
Reach Goodykoontz at email@example.com. Facebook: facebook.com/GoodyOnFilm. Twitter: goodyk.
The Doors are shown in a scene is shown from the film "When You're Strange."
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Cloud Application Development and Testing
Lean budgets and market demands for faster execution require innovative solutions. Modernize your cloud applications to simplify, standardize and add functionality while lowering upkeep costs. Build, transform and test applications for the cloud.
On-demand Infrastructure as a Service (IaaS) to meet the needs for temporary cloud compute and storage resources.
- CSC CloudTest for Web Application Performance
Scalable cloud analysis to validate web site reliability and performance.


text:
Recombinant full length protein corresponding to Rat Cyclophilin F aa 1-206. (also known as CypD)
Our Abpromise guarantee covers the use of ab110324 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
アプリケーション | Abreviews | 特記事項 |
WB | Use a concentration of 1 µg/ml. Predicted molecular weight: 22 kDa. | |
Flow Cyt | Use a concentration of 1 µg/ml. ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
In-Cell ELISA | Use a concentration of 4 µg/ml. | |
ICC/IF | Use a concentration of 5 µg/ml. | |
IHC-P | 1/100. Perform heat mediated antigen retrieval via the pressure cooker method before commencing with IHC staining protocol. | |
This image is courtesy of an anonymous Abreview
Blocked with 5% milk for 1 hour at 25°C.
Incubated with the primary antibody diluted in PBS-T + 5% milk for 16 hours at 4°C.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"


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Big Rapids, Mich. - The Ferris State University women's soccer team won for the fifth time in its last seven outings with a 1-0 shutout over Northwood on the road in Great Lakes Intercollegiate Athletic Conference (GLIAC) action on Sunday (Oct. 9) afternoon in Midland, Mich.
The Bulldogs scored 22:31 into the contest on freshman forward Sam Kay's (Portage/Northern) first career goal at Dean Field and the score stood up as Bulldog sophomore goalkeeper Rachel McCollum (Grand Blanc) did not surrender a goal in 90 minutes of action.
Kay was able to beat NU keeper Rebecca Lipinski out front of the net off a deflection to account for the day's only scoring.
It was the second 1-0 victory in a row for FSU, which also beat Saginaw Valley State by an identical score in league play on the road Friday (Oct. 7) in overtime.
The Bulldogs outshot Northwood 10-8 for the afternoon and had eight on goal compared to only two for the Timberwolves. Ferris also received four corner kick tries while NU had only three corners in the contest.
Freshman midfielder Stephanie Garland (Macomb/L'Anse Creuse North) and sophomore midfielder Hillary Braun (Rochester Hills/Rochester) both had a match-high three shots for the Bulldogs.
McCollum made two saves for the Bulldogs in picking up the win while Lipinski had seven saves overall in the setback for Northwood.
Ferris State did total 11 fouls compared to just one for Northwood and the Bulldogs were whistled for offsides twice on the day. Nine of FSU's 10 shots came in the opening half.
The game was played under sunny skies and 72-degree weather in Midland.
With the victory, Ferris State remains in second place in the GLIAC North Division behind defending national champion Grand Valley State as the Bulldogs own a current 6-2-2 league record and are 6-5-2 overall.
Northwood fell to 4-7 on the year and 3-7 in league play with the loss.
The win was FSU's fifth in its last seven contests and the Bulldogs have lost just once in that seven-match stretch with despite having six of those matches on the road.
The Bulldogs wrap up an eight-match road swing with a pair of matches this coming week in Michigan's Upper Peninsula. FSU first visits Michigan Tech on Friday, Oct. 14, for a 4 p.m. (ET) tilt in Houghton before meeting Northern Michigan on Sunday, Oct. 16, at 12 p.m. (ET) in Marquette.
Ferris Wins For Fifth Time In Last Seven Tries
Oct 09, 2011


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Lakers clear Howard for more practice
Dwight Howard has been cleared for limited five-on-five scrimmages with the Los Angeles Lakers in his latest step back from offseason surgery.
Howard won't play in the Lakers' next preseason game Wednesday night against Portland in Ontario, Calif.
Howard was cleared Tuesday for limited participation in full-court scrimmages with contact. He had participated in every other aspect of the Lakers' practices during training camp except full-court contact.
The six-time All-Star center had surgery on his back last spring.
Howard hasn't projected a date for his Lakers debut, but is hopeful he can participate in a preseason game. After Wednesday's visit from the Trail Blazers, the Lakers will have six more exhibitions before their season opener Oct. 30 against Dallas.


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Always Waining (purple silks) has won three times over the National fences
PICTURE: Patrick McCann (racingpost.com/photos)Topham regular Always Waining National-bound
ALWAYS WAINING, who has won the Topham Chase for the last three years and is ante-post favourite to make it an unprecedented four-timer, will not run in the race he has made his own and will instead bid to translate his form over the fences in the biggest race of the year providing the ground is not too testing.
A John Smith's Grand National bid was mooted last year, but Always Waining failed to make it into the final field. However, that is not a problem this year, with his mark of 143 enough to see him 25th on the list and guaranteed a run.
Should Imperial Commander take his chance, Always Waining would carry 10st 10lb.
Trainer Peter Bowen said: "He worked well this morning and he scoped clean afterwards. He's in good form and I'm hoping we'll get good ground for him.
"We don't know if he'll stay the trip but he never seems to be stopping at the end of the Topham and he ran well over 3m2f in the Becher Chase on heavy ground, which didn't suit him at all."
If the ground did come up testing, Always Waining would switch to the Topham although, ground permitting, the National is Bowen's favoured option.
Always Waining's first Topham success came in 2010, by 12 lengths from Scotsirish off a mark of 128. Success the following year came off 133 by four lengths from Mon Perrain, while last year he beat Chance Du Roy over the 2m5½f by four and a half lengths off a mark of 138.
The three wins represent the last three wins of Always Waining's career, whose form figures including his first win at Aintree read: 1006704184409178.
Another confirmed for the race was the Paul Nolan-trained Joncol. A dual Grade 1 winner, he carries 3lb more than Always Waining and Nolan said: "The plan is still to go and we're not going to make any excuses about ground any more. At this stage of his career we're just going to go for it.
"Our first runner in the Grand National was Colonel Rayburn and while he might not be quite as tall he's definitely heavier. He's a Party Politics type and hopefully he can run half as well as he did."
The going at Aintree on Thursday was good to soft on the National course, good to soft, good in places on the hurdles course and good, good to soft in places on the Mildmay course, with clerk of the course Andrew Tulloch expecting the going to be much the same for the start of next week's three-day meeting.
"It's forecast to get fractionally warmer but only as high as 6 or 7C. We're largely dry on the forecast but it's pretty cold," he said.


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The Storm announced it will open its 16th season Oct. 20 at the Sports Arena against Dayton.
It will be the ninth straight season Toledo has opened at home. The Storm will start with seven of its first eight games at the Sports Arena.
On Nov. 3, the Florida Everblades will come to the Sports Arena in the first-ever regular- season meeting. Also making its first visit to Toledo will be the Columbia Inferno on Feb.16-17.
The Storm has just three home games in February which includes traveling to Las Vegas for three games and to Bakersfield, Calif., for one.
Season tickets are on sale at the Storm office at 419-691-0200.


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Free personalized radio that
plays the music you love
Gilberto Gil
He began playing the accordion when he was eight, and he listened to street singers in the marketplace around Salvador. By the end of the '50s, Gil was studying business administration at Salvador's Federal University and playing with a group called Os Desafinados. At this time he heard singer and guitarist João Gilberto on the radio and was so impressed that he immediately bought a guitar and learned to play and sing the bossa nova. He spent the early '60s composing songs for TV ads, and in 1964, he was in Nos Por Exemplo, a show of bossa nova and traditional Brazilian songs directed by Caetano Veloso. In 1965, he moved to São Paulo, and after singing and playing in various shows, he had his first hit when singer Elis Regina recorded his song "Louvacao." He began to establish himself as a singer of protest songs, and he became very popular with Brazilians involved in the Tropicalia movement, which opened up native Brazilian folk music to other kinds of influences. The success of the single "Louvacao" inspired Gil to record an album of his own material with the same title.
Gil made his first self-titled recording in 1966, but his first hit single didn't come about until 1969, with "Aquele Abraco." His musical fusion of bossa nova, samba, and other styles was so revolutionary it frightened the country's military dictatorship into arresting him, and that's when he headed to Great Britain. (He and Caetano Veloso were placed in solitary confinement while authorities figured out what they wanted to do with the pair.) After three years in England, where he had the chance to work with groups like Pink Floyd, Yes, the Incredible String Band, and Rod Stewart's band in London clubs, he returned to Brazil in 1972. He recorded Expresso 2222, which spurred two hit singles in Brazil, "Back in Bahia" and "Oriente." After playing at the Midem Festival in France in 1973, Gil recorded Ao Vivo in 1974. A year later, he recorded with Jorge Ben for the album Gil & Jorge. In 1976, he toured with Veloso, Gal Costa, and Maria Bethânia and released the Doces Báraros album.
For most of the rest of the '70s, he recorded for a variety of Brazilian record companies until signing an international deal with the WEA group of labels in 1977. He toured U.S. colleges in 1978 and firmly established his place in the international jazz world with his albums Nightingale (1978) and Realce (1979). He also released a double-live album in 1978, Gilberto Gil ao Vivo em Montreux, recorded during his performances at the jazz and blues festival in Switzerland. In 1980, Gil teamed up with reggae musician Jimmy Cliff. The pair toured Brazil, and Gil's cover of Bob Marley's "No Woman, No Cry" climbed to number one, selling 700,000 copies. Gil followed up in 1981 with Luar (A Gente Precisa Ver o Luar), one of his most acclaimed recordings. In 1982, he performed again at the Montreux Festival, but this time with Jimmy Cliff. He followed up with Um Banda Um (1982), Extra (1983), and Raça Humana (1984), the last recorded with Bob Marley's Wailers.
In the late '70s, Gil became a prominent spokesman for the black consciousness movement then taking place in Brazil. In 1982, he had huge crossover success with "Palco," which became popular in dance clubs and led to stadium tours of Europe. Meanwhile, back in the U.S., he would play mid-sized jazz clubs in New York City and Los Angeles. Gil celebrated his then-two-decade career in 1985 with the album Dia Dorim Noite Neon (released in the U.S.), and released Gilberto Gil em Concerto, recorded live in Rio, in 1987. The early '90s saw Gil continuing his involvement in social and political causes in his native country, finding widespread support for his political stances, and he was elected to office in the port city of Salvador (aka the Black Rome), his hometown. In 2003, Gil began serving as Brazil's Minister of Culture, and two years later, he received Sweden's Polar Music Prize and a Légion d'Honneur from the French government. Gil continued to maintain a recording career throughout the '90s and 2000s, including the 2008 release Banda Larga Cordel. In 2008, he stepped down from his position as Minister of Culture for health reasons. Two years later, he returned to music, releasing Fé Na Festa in 2010. In 2015, five decades into his remarkable career, Gil teamed with contemporary and longtime friend Caetano Veloso on a major world tour called "Two Friends, a Century of Music." Commemorating the tour was a concert album recorded during one of their Brazilian shows called Dois Amigos, Um Séc**o de Música: Multishow Live. The double album was released by Nonesuch Records in April 2016. ~ Richard Skelly
Selected Discography
Track List: Gilbertos Samba Ao Vivo
Track List: Live In London '71, Vol. 2
Track List: Live In London '71, Vol. 1
Track List: The Essential Gilberto Gil
Track List: Gilbertos Samba
Track List: Você E Eu
Track List: Original Album Series
Track List: Fé Na Festa
Track List: Gil Canta Luiz Gonzaga
Track List: ICollection: Gilberto Gil
Track List: Dose Dupla Gilberto Gil
Track List: Minha Princesa Cordel (Single)
Track List: Fé Na Festa: Ao Vivo
Track List: Bandadois: Live
Track List: Retirante, Vol.1
Track List: Metamorfosicamente
Track List: Banda Larga
Track List: A Cama E A TV
Track List: Duetos
Track List: Gil Luminoso
Track List: It's Good To Be Alive - Anos 80
Track List: Sao Joao (Vivo)
Track List: Parabolicamará
Track List: Ao Vivo Em Tóquio
Track List: It's Good to Be Alive - Anos 90
Track List: A Pessoa É Para O Que Nasce
Track List: Soy Loco Por Ti América
Track List: Cidade Do Salvador
Track List: The Early Years
Track List: Eletracústico
Track List: Kaya N'Gan Daya
Track List: Z300AñosDeZumbi
Track List: As Cancoes De Eu, Tu, Eles
Track List: O Sol De Oslo
Track List: Quanta Live
Track List: Quanta Gente Veio Ver (Ao Vivo)
Track List: Quanta (Bonus Tracks)
Track List: Quanta
Track List: Quanta (2 Disc Version)
Track List: Refavela
Track List: Acoustic
Track List: O Eterno Deus Mu Dança
Track List: Gilberto Gil em Concerto
Track List: Dia Dorim Noite Neon
Track List: Raça Humana
Track List: Extra
Track List: Mestres Da MPB
Track List: Mestres Da MPB 2
Track List: Um Banda Um
Track List: Luar
Track List: Nightingale
Track List: Realce
Track List: Montreux Jazz Festival - Ao Vivo
Track List: Refavela - Palco Box
Track List: O Viramundo, Vol. 2 (Ao Vivo)
Track List: Refazenda
Track List: Cidade Do Salvador, Vol.1
Track List: Cidade Do Salvador, Vol. 2
Track List: Expresso 2222
Track List: Gilberto Gil (1971)
Track List: Copacabana Mon Amour
Track List: Gilberto Gil (1969)
Track List: Gilberto Gil [1968]
Track List: Louvacao
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text:
Original URL: http://www.theregister.co.uk/2007/01/19/ams_ix_record/
Amsterdam claims net data record
Our internet exchange is meatier than yours...
Posted in Networks, 19th January 2007 15:04 GMT
The Amsterdam Internet Exchange (AMS-IX) is claiming to be the world's largest public Internet exchange, after setting a new traffic record earlier this month of 233Gbit/s. It says it now shifts more than 1.5 Petabytes a day, on behalf of over 250 ISPs and carriers.
To support that load, AMS-IX has had to invest in yet more switching capacity. It has built up its duplicated core network, which now comprises six BigIron RX-16 switches from Foundry Networks. These are installed in two of its four co-location sites, and once fully configured, the core switches will have 64 10Gig ports each for connection to edge switches and 10Gig customers.
"AMS-IX hit a historical milestone in November when traffic flowing across our infrastructure exceeded 200Gbit/s," said Henk Steenman, the exchange's CTO. Traffic volumes continue to increase at around 3 percent a month, he added. ®


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These Apparitions of the Virgin Mary to the seer
Veronica Lueken recapitulate and update Jesus' and the Virgin Mary's messages
at past true apparition sites, such as the apparitions of the Virgin Mary
at LaSalette, the apparitions of Our Lady of the Miraculous Medal in Paris,
the apparitions in Lourdes, and even the recent apparitions of the Virgin
Mary in Garabandal, Spain.
These apparitions given to Veronica by Jesus and the Virgin Mary concern revelations
of the present Reign of Antichrist (666), the Great Warning, the Miracle.
the Great Chastisement in two parts: 1) World War III, 2)the Earth Comet-struck;
the Second Coming of Christ, and the Great Era of Peace to follow. Miraculous
photos, cures, conversions and other supernatural signs and wonders abound
as proof of Heaven's presence. Check out the Bayside Message translated into
French, Spanish & Italian.
Les Messages en français
en español
en italiano Introduzione,
10 & Marzo 18, '73
Perpetual Rosary Vigils
Press Release on Pope Francis
The Apparitions of the Virgin Mary at Bayside date back to the year 1970 when Veronica Lueken, the chosen instrument of Heaven, was graced with the first of a series of Apparitions in her home on April 7th. Our Lady instructed the seer to hold Vigils of Prayer during the apparitions of the Virgin Mary on the eves of the great feast days of the Church on the grounds of the old St. Robert Bellarmine Church in Bayside, in front of the statue of Our Lady of Grace (since 1975, they are held at Flushing Meadows-Corona Park in Flushing, Queens, NewYork). She promised that during these apparitions She would give her a Message for the world beginning on June 18th that year. The Apparitions of the Virgin Mary continued for 25 years until Veronica's death on August 3, 1995; however, the Vigils of Prayer continue to the present day.
of the Virgin Mary to Veronica Lueken


text:
SET Exam Centers
The Maharashtra State Eligibility Test for Lectureship is conducted by Pune University in 12 different centers. They are Chandrapur, Solapur, Goa, Nagpur, Amravati, Nanded, Aurangabad, Jalgoan, Nashik, Kolhapur, Pune and Mumbai.
For making the process of applying for the SET examination easier, online application facility is made available to the candidates in the web site of Maharashtra State Eligibility Test for Lectureship. The candidates can apply online through the application form published in the web site. After duly filling in the form, with all the required details, the candidates will have to click the submit button. After this submission, the candidates will be allotted a unique application number and the candidates should take a note of this number.
After taking a note of this number, the candidates will have to take a print out of the application form submitted. Along with this print out the candidate has to enclose the final year mark sheet of their master's degree, medical certificate in the case of physically handicapped and visually handicapped candidates, community certificate in the case of reserved category candidates and the demand draft drawn in favor of the registrar, university of Pune at any nationalized banks payable at Pune for an amount of Rs.550 for general category candidates and Rs.450 in the case of ST/SC/VH/PH candidates.
The candidates can send the duly filled in application form along with the required documents through registered post or in person to any of the 14 collection centers specified in the following link: http://setexam.unipune.ernet.in/CollectionCenters.html. The addresses of these centers with the name of the contact person have clearly been specified in the above-mentioned link.
The candidates will be able to get the admit cards from the web site of Maharashtra SET examination 15 days before the date of examination and the same will not be sent to the candidates by post.
Please Wait
- Be first to post a comment


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Thursday, April 16th, 2009
By William Kincaid
Taking a stand
More than 200 people gather in St. Marys for protest of the government
ST. MARYS - Rev. Mark Foor of First Baptist Church, St. Marys, says the U.S. today is not the same country it was when he was growing up.
With his face painted blue - and adorned with a garbage can shield and sword - Foor evoked Scottish freedom fighter William Wallace and urged his countrymen to stand up for their liberties during a Taxed Enough Already (TEA) party held Wednesday afternoon in St. Marys.
On a cold gray day, more than 200 citizens encircled the St. Marys City Building on Spring Street. American and Marine flags were hoisted, while others toted signs with such slogans as "Keep Our Country Free! Too Much Gov't" and "Obama Wants Your Money."
"Socialism sucks," one man screamed through the crowd.
A podium and loud speaker were open to anyone who wanted to voice their discontent.
Foor bellowed his laments against the government, primarily the current administration's taxation policies, to the approval of the crowd. The middle class, he said, has a right to property, whether through owning, manufacturing or repairing.
Foor, sworn in as a U.S. Marine on Jan. 19, 1971, said he is neither for corporate fascism nor socialism, which he believes have spread pervasively through the country.
On Wednesday, Foor said he is still committed to fighting enemies both foreign and domestic and called for a third political party: a Constitutional party.
"I was surprised there were (that) many people," Foor said of the attendees, adding he has no problem being perceived as a kook.
Protesters in St. Marys joined tens of thousands of other dissenters throughout the country on Wednesday (tax day, the last day to file income taxes) as part of a national grassroots movement objecting to government bailouts and gross spending of taxpayer dollars.
St. Marys resident Judy Weng spearheaded the local event.
"The American Family Association was looking for people to represent their areas," Weng said, adding she volunteered for the event a few weeks ago. St. Marys businesses Valentine Photography and Carter Lumber donated supplies for signs.
Weng said she was impressed with the turnout.
State Rep. John Adams, R-Sidney, told the crowd to voice their concerns to their representatives.
"The government needs to hear from you," he said.
Adams said he is sick of people leaving Ohio in search of jobs and lower taxes.
"What kills jobs in the state of Ohio is high taxes," he said through a microphone.
The movement is not rooted in Republican or Democrat ideology and is neither conservative nor liberal, Adams claimed.
Ohio, which lost 220,000 jobs the last 12 months, needs growth, he said.
"We'll walk with our feet. We'll voice our opinions," he said.
Additional online stories for this date
Print and E-Edition only stories for this date
• Club learns not all that sparkles is champagne
• Local Republican legislators express budget concerns
• Construction projects ongoing
• St. Henry's hot bats carry Redskins to victory
• Cavs' first state title run nearly never happened
• Klenke, Geeslin pick traditional powers for college
Wednesday Night
Thursday Night
Friday Night
Saturday Night
Sunday Night
Monday Night
3 Day


text:
Why Is Wikipedia So Ugly? 370
Hugh Pickens writes "Megan Garber writes in the Atlantic that aesthetically, Wikipedia is remarkably unattractive. 'The gridded layout! The disregard for mind-calming images! The vaguely Geocities-esque environment! Whether it's ironic or fitting, it is undeniable: The Sum of All Human Knowledge, when actually summed up, is pretty ugly.' But Wikipedians consider the site's homeliness as a feature rather than a bug. 'Wikipedia has always been kind of a homely, awkward, handcrafted-looking site,' says Sue Gardner, executive director of the Wikimedia Foundation, adding that the homeliness 'is part of its awkward charm.' Facebook, Twitter, and Tumblr have built followings in part because of their exceedingly simple interfaces. Everything about their design says, 'Come on, guys. Participate. It's easy,' while Wikipedia, so far, has been pretty much the opposite of that. 'The free encyclopedia that anyone can edit' might more properly be nicknamed 'the free encyclopedia that any geek can edit.' This is particularly problematic because one of the Wikimedia Foundation's broad strategic goals is to expand its base of editors. While the editing interface is friendly to the site's super-users who tend to be so committed to Wikipedia's mission that they're willing to do a lot to contribute to it, if Wikipedia wants to make itself more attractive to users, a superficial makeover may be just the thing Wikipedia needs to begin growing in a more meaningful way."


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Effective Management—Scientific Techniques vs Practical Experience by GORDON L. MURRAY Partner, Executive Office Adapted from an address given before the Financial Executives Institute, Columbus—November 1964 I ORIGINALLY DEVELOPED the material for this talk in response to a request from the Los Angeles Chapter of The Financial Executives Institute that I speak on this specific subject. They asked that the talk touch on four points: Effectiveness of Operations Research and Pure Mathematics vs. Practical Experience. Are computers taking over and financial executives becoming obsolete? Is the financial man relinquishing part of his responsibilities to new specialists—by default, by lack of training, or unwillingness to accept new changes? What is effective management and how may the financial man keep himself abreast of new developments? The Los Angeles request ended up by suggesting, "Please make this controversial, if you want to." I liked this last point but the fact is, I don't have to. The very essence of the subject matter is controversial. Business literature is replete with comment on this subject. The whole matter is being churned, analyzed, and discussed and no clear pattern of thought appears to have emerged. Comment runs the whole range from speculation of the Jules Verne science-fiction variety to a cynical attitude that scientific management-operations research-mathematical sciences are a fad without substance and without a real contribution to make in business affairs. A speaker on this subject has several choices open to him. He can dream and speculate that the mathematician and the computer are about to inherit, if not the earth, at least the management of our business affairs. He can speculate and philosophize on the socio-economic effect of the math-science-computer trend. On the other hand he can debunk the whole subject and conclude that all this is not for him or his company—that the subject is "way-out"—and he can be amused by it all. I too like to dream and speculate about what may be in the future, but circumstances require that I earn my living by dealing with what is here today. It is difficult to "sell" what "may be" as a professional 309
Object Description
Title |
Effective management -- Scientific techniques vs practical experience |
Author |
Murray, Gordon L. |
Subject |
Management |
Office/Department |
Haskins & Sells. Executive Office |
Citation |
Haskins & Sells Selected Papers, 1965, p. 309-325 |
Date-Issued | 1965 |
Source | Originally published by: Haskins & Sells |
Rights | Copyright and permission to republish held by: Deloitte |
Type | Text |
Format | PDF with corrected OCR scanned at 400dpi |
Collection | Deloitte Digital Collection |
Date-Digitally Created | 2009 |
Language | eng |
Identifier | hs_sp_1965_pages_309-325 |


text:
Clearly, the whole Miami-Cleveland beef doesn't interest the Heat anymore. Just as clear, the Heat can win on a night it sleepwalks through a game and only begins playing in the final minutes.
Such was the case on Saturday night at AmericanAirlines Arena.
Miami trailed by seven points with less than two minutes remaining but scored nine straight points to extended its home winning streak to six games. LeBron James had 30 points in the Heat's 110-108 victory against his former team.
"Our guys absolutely relish those moments in the fourth quarter, that competitive spirit … and we need to get out of here as quickly as we can before they put more time on the clock," Heat coach Erik Spoelstra said.
No doubt about it, the Heat (10-3) sneaked out of the back door of the arena with this one.
James found Ray Allen open for a three-pointer from the wing with 18.2 seconds left, and Allen buried the shot to give the Heat a 109-108 lead. The Heat never led by more than three points the entire game. Cleveland (3-10) was 14 of 31 from three-point range.
Allen had 15 of his 17 points in the fourth quarter. He was 5 of 6 from the field in the period and 3 of 4 from three-point range.
"You don't need much room at all," James said of Allen's quick release. "I feel like Tom Brady in the playoffs."
NBA Headlines
Late three from Ray Allen caps Miami Heat rally in win over Cleveland Cavaliers
Miami Herald | Nov 25


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Community RxScrapping Volunteer Model Meant Curtains for Activist Conscripts and Paved Way for TAG Ascendency
May 2002 A note from TheBody.com: The field of medicine is constantly evolving. As a result, parts of this article may be outdated. Please keep this in mind, and be sure to visit other parts of our site for more recent information! "Urgent Need to Teach, Train"Survey the leadership of major AIDS advocacy organizations, scan the mastheads of treatment publications, and chances are you'll come across name after name of T+D and TAG alumni/ae. Peppered throughout the ranks of medical residency programs, AIDS service organizations, HIV vaccine groups and research labs across the land are the young men and women who were first initiated into the heady mix of science, social policy and protest through the living room training ground of 1990s treatment activism.And as these same pioneers, many of them surprised to find themselves still among the living, slip gracefully into their (often staid) middle years, they leave in their stead somewhat of a dwindling pool of fresh recruits. The activist M.A.S.H. units have long ago rolled up their tents and left town. Activist apprenticeships are now something of an anachronism, if not extinct entirely. The NATAFs and ATACs and CCGs promise to institutionalize the identification and training of ambitious new protégé(e)s. But will they prove sufficient, in this post-millennial activist age, to ensure a steady maturation of quick-witted, crackerjack idealists? David Barr surveys the landscape, past and present, to ponder what we've given up to get where we are today. One of the things that made ACT UP so special was that it was made up of ordinary people who wanted to make a difference in the struggle against the neglect of the AIDS crisis. Many of us had AIDS ourselves, and our activism provided us with a way to fight back and find strength. Particularly for those of us who got involved with treatment and research activism, the work was a constant and challenging learning process. Most of us had little to no background in science or medicine. We taught ourselves and each other about how drugs are developed, how clinical research is conducted, how to understand the study results. As new people would come into the fold, they would learn from those who had already developed some understanding. We had teach-ins, trainings, and countless meetings where issue after issue would be discussed and debated. People would volunteer for projects: become "drug buddies" following the research progress of each new drug, devising a plan to move the research faster or make it better. The new people learned from the more experienced people. That was how the model of the treatment activist was created. Those TAG meetings produced some monumental work, but the dinners that often followed them were just as important to me. The camaraderie we felt provided solace and support. Yes, it was often a competitive environment, but the friendships created through TAG in those years were strong and, despite the competition and constant bickering, deep and fulfilling. As time went on, however, the work became more complex, more specialized. As activists became more of a part of the research process, the need for full-time workers grew. A small group of people became responsible for the most of the work. These people needed financial support from the organization in order to do this work full-time. Also, because the TAG leadership was becoming responsible for the bulk of the work, they needed the authority to make decisions and set priorities for the group. Administrative and fundraising needs also grew. The success of the organization required a change in structure. TAG moved to a more traditional model of an advocacy organization -- one governed by a Board of Directors and led by a paid staff. This change -- the "professionalization" of the treatment activist -- was essential. Without this change, the next phase of the work would not have been accomplished. That work, including the pivotal report on the AIDS research effort at the NIH and the passage of the NIH Revitalization Act, required full-time staff who received the support -- financial and administrative -- that only a Board/staff structure could provide. The value of that structural shift is seen in the continued success of TAG and other treatment advocacy organizations like it. But that change also came at a cost. What was sacrificed was the membership. TAG was no longer a place where newcomers could learn how to become treatment activists. It was no longer a place where you could learn by volunteering for a project and work your way up through the ranks into a position of leadership. Those opportunities became few and far between. Also lost was the sense of support and community that the membership model provided. Of those who have survived, so many have drifted away because they no longer had a role to play. The changes in structure of TAG were essential. TAG would not have continued to grow and be as effective as it became without them, but the costs were great. The membership knew the change was needed and voted to approve the shift to a Board/staff model. It was a difficult and painful discussion. Membership and committee meetings continued, but gradually, their value diminished. The real work was now taking place in between the meetings. Rather than strategy sessions, the meetings became reports. As people no longer felt their presence was helping to produce change, they stopped coming. One negative result of this change was -- and is -- the difficulty of building new leadership. Another result was an increasing elitism among the small group of advocates who were now employed to attend meetings with government and industry, write reports, and implement strategies to affect change. Indeed, the initial process of coming up "through the ranks" was never successful at ensuring that all communities affected by HIV could participate in the work. Research advocacy is a luxurious area of activism. Activists from poorer communities often have to work on health care access, housing needs, and other priorities before they can turn their attention to the rarified world of clinical research. There is an urgent need to create a more formal infrastructure to teach, train and promote a diverse group of activists to engage in the research and drug development process. Otherwise, we risk losing the gains we have made in the goal of creating a permanent voice for patients in the research and drug development process. There are some good attempts to do this: the National Institute for Allergy and Infectious Disease (NIAID) Community Constituency Groups have helped to serve this function; and the African American HIV Policy Institute has developed an ambitious treatment advocacy training program. Most recently, the formation of the AIDS Treatment Advocacy Coalition (ATAC) promises to provide an excellent training ground for new advocates as well as an infrastructure for greater inclusion. In the 1980s and '90s, people with AIDS created a new role for patients in the research and drug development process. Our argument was always that including people living with HIV in this process would not only better meet our needs as consumers, it would make for better science. I believe that argument has been proven true over and over again. In order to continue that effort, we cannot rely on chance volunteerism. We have to provide education, training, financial support, and infrastructure. The importance of our work deserves that.
Back to the TAGline May 2002 contents page.
A note from TheBody.com: The field of medicine is constantly evolving. As a result, parts of this article may be outdated. Please keep this in mind, and be sure to visit other parts of our site for more recent information! This article was provided by Treatment Action Group. It is a part of the publication TAGline.


text:
2010-10-26, 01:22 | Link #1061 |
Senior Member
Join Date: Oct 2010
Hmmm, was that an expectant or an unconcerned "so?" Either way, making good on the declaration. These are a few of the ones I don't remember having seen on this site.
Spoiler for size:
Apologizes for size. I haven't quite mastered turning them into thumbnails. |
2010-10-27, 16:08 | Link #1065 |
reads too much
Join Date: Oct 2008
Location: you know that's a great question.....
I love that first one, what a pretty style! (And why am I getting Nura vibes from the last one...?)
EDIT: Just noticed that the picture is titled Space and Wolf though, which is going to bother me each time I look at it now.
Last edited by wandering-dreamer; 2010-10-27 at 19:34. |
2010-10-27, 23:26 | Link #1067 | |
My wolfu is >> your waifu
Join Date: Feb 2010
Location: Charleston, West Virginia
Age: 35
Now I really have to add some of my collection! Once I get some time, I promise I will. Does anyone here know someone who can tender some awesome Holo art... I have some amazing ideas that I want to see brought to life!
2010-10-30, 14:57 | Link #1070 | |
My wolfu is >> your waifu
Join Date: Feb 2010
Location: Charleston, West Virginia
Age: 35
Second one... uhhhhhh... no... that just ain't right. Ryuk ain't worthy to hang around with her. Third one... really cute looking... seen it before but forgot about it! Last one... just really nice!
2010-10-30, 15:23 | Link #1071 |
Team Spice and Wolf UK
Join Date: Feb 2010
Location: England
Age: 29
"Space and Wolf"...sounds like a futuristic side project novel, if Holo was to survive beyond the 'modern' era, and into the future.
Lets face it; she's got the longevity, so its ACTUALLY a possibility. With improvements in concealment technology it'd probably also be a lot EASIER to be her Now there's an image. "In space....no one can hear yo..... OOOOOOH APPLES!" Picture that one
2010-11-02, 17:32 | Link #1076 |
Team Spice and Wolf UK
Join Date: Feb 2010
Location: England
Age: 29
Lol ooh-err. Holo's not as naive/immature as she appears. Wonder what on earth she could have in mind there....at least based on the impression....and what little you can see of Lawrence's! *innocent*
2010-11-08, 06:06 | Link #1078 |
Senior Member
Join Date: Oct 2010
No idea what she's saying, but it looks like she's force-feeding him chocolate. Doesn't look like she needs much force, either.
Spoiler for army chibi holo images!:
Spoiler for comic with rough translation:
People have posted most of these here, but I don't remember which ones, so I'm posting all the Chibi Horo I have. Hope at least some of it is new. |
2011-03-13, 12:07 | Link #1080 | |
My wolfu is >> your waifu
Join Date: Feb 2010
Location: Charleston, West Virginia
Age: 35
I wanna see what all you have saved in there... I hope it is back up soon. **** Nice collection, buy you may wanna let people know that some of those may not be quite appropriate. I'm gonna have to thin out some of those if I'm gonna keep them on my hard drive.
Last edited by Rajura; 2011-03-13 at 12:50. Reason: Update |
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Michigan, Ohio, Marines, recruits participate in female pool function
ROMULUS, Mich. (Jan. 29 2014) - More than 40 members of Recruiting Station Detroit participated in a female pool function in Romulus, Mich., Jan. 18, to build camaraderie and spread knowledge about the Marine Corps among future Marines before they attend recruit training.
Maj Matthew Hager, RS Detroit's commanding officer, and SgtMaj Adam Yakubsin, RS Detroit's sergeant major, welcomed attendees with comments about the challenges that lay ahead, while reminding them they will not face them alone.
"I hope to receive good feedback from those who attended, to ensure we are providing the right guidance to prepare them for recruit training," said Yakubsin.
One recruit, Isabel Magana, who spent less than a month in the Marine Corps Delayed Entry Program, was happy she finally found her niche.
"The Marines are the best," said Magana. "I cannot wait to explore the world, meet people and experience different cultures and enjoy life."
When asked about the pool function she expressed her gratitude and confidence in her decision for joining the Corps.
"The function was very helpful and answered a lot of questions I had," said Magana, who is 27, and a recruit out of Recruiting Sub-Station Howell, Mich. "It is comforting to be around females; sometimes the male recruiters do not know how to answer my questions about recruit training for females."
Magana, who left for Marine Corps Recruit Depot Parris Island, S.C., Jan. 27, is slated to be a legal administrative specialist. The recruits were able to interact with other applicants who shared common concerns such as how to properly pin up their hair, what physical demands they were going to encounter, and what communication will be like on the island.
"The Marines made the event very comfortable for us to ask questions," said Hannah Kuhlman, 20, a recruit out of RSS Findlay, Ohio. "These were not rumors or hearsay, these are Marines who have gone through boot camp."
This is just one of RS Detroit's two female functions this year that will continue to instill confidence in the station's females recruits, according to Yakubsin. Female Marines with the station discussed concerns the recruits had before going into boot camp and later conducted a physical training circuit.
"I think these types of functions are important," said Yakubsin. "It brings everyone together and it helps them build a bond with other females who are leaving for recruit training."
"It's a great experience that I have had; and seeing all these females," continued Magana. "I feel like hey, maybe I will run into them in the future, as Marines."
Marines.mil is the official website of the United States Marine Corps and is maintained by the Marine Corps' Division of Public Affairs.


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Ground was broken for the visitor center in 1991. Its facade is that of a Greek Revival memorial. It stands less than 100 yards east of the original Fort Davidson. Free tours are given during operating hours, which are listed below. Inside, several themes are interpreted, including:
The development of the Arcadia Valley
A 22-minute video program covers early settlement through the Civil War and Reconstruction.
The Battle of Pilot Knob
A fiber optic diorama display, permanent exhibits and a slide program focus on the days of Sept. 24 through Oct. 3, 1864. Click here to read the diorama script.
General Price's raid into Missouri in 1864
This exhibit broadly covers the sweeping scope of Price's raid from its purpose, development and planning through its retreat and the effects it had on the outcome of society, politics and the war.
Fort Davidson
A permanent display and model of the key battlefield structure interprets its reason for existence, its construction and its importance during the war as a hub of Union activities in Southeast Missouri.
Missouri in the Civil War
This broad theme describes the major battles fought in Missouri to add perspective for our audience.
The commanders, Gen. Price and Gen. Ewing
An exhibit outlines the characteristics and careers of the two opposing commanders.
The Missouri Civil War soldier
Permanent displays include that of the African-American soldier and highlight the clothing, gear, personal items, living conditions and societal conditions that soldiers endured during the war.
Local weapons and military items used during the Civil War
Displays of artifacts, restorations and reproductions of Civil War era rifles, infantry gear, cannonballs and other projectiles and cavalry items provide the audience with artifacts showing both commonly used weapons during the Civil War and weapons unique to the soldiers at Pilot Knob.
Pilot Knob after the battle
A display box covers the post war life of the Fort Davidson battlefield.
Battlefield artifacts from the area
Such as Gen. Ewing's field sword, Capt. Pinckney Power's sword and the locally renowned Allers Collection
Flag displays
Examples of the common flags used in the Trans-Mississippi theatre of war.
In addition to the exhibits, you will find a variety of Civil War souvenirs, books, compact disks and tapes. Books kept in stock largely deal with the Battle of Pilot Knob, Civil War Missouri, and the Trans-Mississippi theatre of war. Information about local history and the Arcadia Valley self-guided Civil War trail are available at the site.
Summer Hours (On-Season)
April 16 through Nov. 30
10 a.m. to 4 p.m., daily (with the exception of Thanksgiving Day) -
Winter Hours (Off-Season)
Dec. 1 through April 15
10 a.m. to 4 p.m., Tuesday through Sunday (with the exception of New Year's and Christmas days).
Free tours are offered during these times.
37.620278, -90.638889