text:
404 when doing bundle install omniauth-linkedin
Hello - it seems when I run bundle install I get an error from rubygems.org CDN saying its a 404 and the resource doesn't exist.
I am not sure what is going on but this thread on SO pretty much articulates the exact issue I am having:
I can run gem install just fine, however when using bundle
install it is trying to grab the 0.0.4 version of this gem(which is
2 versions old). Here is the message I get `fetch_http': bad
response Not Found 404 (http://production.cf.rubygems.org/quick/Marshal.4.8/omniauth-linked...)
The specified key does not exist.
Any idea why this is occurring? It was working up to a week ago but I just had to rebuild my gems and I got surprised with this. I got around it by linking directly to the gem in github but this is not the way we like to include gems.
Sorry, this comment was buried in our spam inbox.
Looks like there was a problem uploading this gem to S3. I've yanked it.
I've added skorks to this discussion, as a heads up. Sounds like this isn't the active version, but if you still have this gem we can re-upload it to S3.
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subset: commoncrawl


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This is a summary. To read the whole story subscribe to BostonGlobe.com
ST. LOUIS — The Cardinals have a rich tradition, but whether their prolonged success would endure would be seriously tested following their World Series championship in 2011.
Manager Tony La Russa decided to step down, but more shockingly three-time MVP Albert Pujols left the team that drafted and developed him for a 10-year, $240 million contract with the Angels.
The Cardinals would have to rely on their remaining roster, as well as an aging Carlos Beltran, who was added on a two-year $26 million deal.
In the two years Pujols has been in Anaheim, the Cardinals came within one game of the World Series in 2012 and are in the Fall Classic again this season, ready to face the Red Sox in Game 1 Wednesday night.


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by Zach Roberts
The Warriorettes were ready to defend their home turf against the North Harrison Lady Cougars. Coming into this game, both teams were definitely going to look towards their one of their more stronger assets, which is rebounding.
by MAGGIE WHITE
AHS Sports Correspondent
A continually improving Austin Lady Eagles basketball team traveled to Charlestown on Wednesday night, December 4, to play the Charlestown Lady Pirates in yet another barn-burner of a game.
The Austin Lady Eagles made the long bus ride to challenge the Lady Rams of Paoli on Thursday, November 21.
Homestyle Dining LLC, which operates and franchises the Ponderosa and Bonanza Steakhouse restaurant concepts, has announced the recipients of its annual franchise and brand support awards. The awards, which recognize excellence in operations on both the franchise and supplier level, were given at the company's 2013 Franchise Conference in Nashville in October.


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Cokie Roberts to Address Women in Transportation
February 5, 2014 - (Washington, DC) Cokie Roberts, best-selling author and award-winning journalist, has been confirmed as the keynote speaker for the 2014 annual conference of WTS International, the association for the professional advancement of women in transportation that will take place May 14 - 16, 2014, in Portland, Oregon. "When we plan the conference each year we seek to provide our members and supporters with a keynote presentation that touches on the core of our mission, and Ms. Roberts epitomizes our association's guiding mission of attracting, retaining, and advancing women in transportation, an industry with very few women in top roles and few young women focused on STEM studies or entering this important industry," said Margaret Mullins, director of the WTS Annual Conference. "Cokie Roberts, an icon in the media and a role model herself, will be talking to conference attendees about the drive, determination, creative insight, and passion of the women who raised our nation to illuminate the social issues effecting women today." "The transportation field is among the world's most male-dominated industries, said Marcia Ferranto, WTS International's President and CEO, "and as WTS members work to help each other develop professionally and climb through the ranks in both the public and private sectors, we can take pride in knowing that we are helping to build the world's infrastructure through the advancement of women, and shaping future generations of transportation leaders. Ms. Roberts' remarks will certainly inspire this association further when she addresses them in May in Portland." The Annual Conference is WTS International's flagship event. It attracts more than corporate and governmental industry leaders worldwide, including executives, CEOs, government administrators, and leading transportation authorities. Attendees at the conference gather to network, discuss the state of the world's transportation infrastructure, strategize on advancing professionally through glass ceilings, and explore the local city's successful municipal and private transportation and transit projects. For the full duration of this year's Portland conference, private corporations, public agencies and government officials invested in every transportation mode will exhibit, present, learn, and network. Cokie Roberts is a political commentator for ABC News, providing analysis for all network news programming, as well as for NPR. In her more than 40 years in broadcasting, she's won countless awards, including three Emmys. She's been inducted into the Broadcasting and Cable Hall of Fame, and was cited by the American Women in Radio and Television as one of the 50 greatest women in the history of broadcasting. In addition to her appearances on the airwaves, she's a contributing editor to USA Weekend Magazine, and she co-authored From this Day Forward, an account of her more than 40-year marriage and other marriages in American history. The book immediately went onto The New York Times "best sellers" list, following her number one best seller, We Are Our Mothers' Daughters, an account of women's roles and relationships throughout American history. Ms. Roberts' histories of women in America's founding era, Founding Mothers, published in 2004, and Ladies of Liberty published in 2008, also became instant best sellers. Ms. Roberts holds more than 20 honorary degrees, serves on the boards of several non-profit institutions and on the President's Commission on Service and Civic Participation. In 2008, the Library of Congress named her a "Living Legend." For more information on the 2014 Annual WTS Conference, visit www.WTSinternational.org or contact Margaret Mullins, Operations Director, at 202-955-5085.


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Article 17 of the EU Short Selling Regulation (EU236/2012) (the Short Selling Regulation) provides for certain exemptions for market-making activities and primary market operations from the requirements to make notifications and public disclosures of net short positions and the restrictions on entering into uncovered short sales under the Short Selling Regulation. This exemption can be used by a person who has made a "legitimate notification" to the relevant competent authority at least 30 days before the exemption is intended to be employed and where the competent authority has not objected to its use. (On September 17, the European Securities and Markets Authority (ESMA) published a consultation paper on guidance on the exemptions under Article 17; see the September 21, 2012, edition of Corporate and Financial Weekly Digest.)
On September 24, the UK Financial Services Authority (FSA) published guidelines for the making of notifications to the FSA in order to obtain market maker and primary dealer exemptions under Article 17. The exemptions apply only to transactions carried out in performance of market-making activities or as authorized primary dealers; they do not apply to other activities carried out by the entity making the notification. Since notification must be made to the relevant regulator 30 days before it is relied on, for an entity to be able to rely on an exemption from November 1 (the date the Short Selling Regulation comes into effect), the FSA must receive any relevant notification no later than October 2.
Read more.
On September 26, the FSA published the relevant notification forms. They require detailed information (including name of issuer, type of financial instrument and ISIN code (International Security Identification Number)) for each instrument with respect to which a market maker or primary dealer exemption is notified.
See more
DISCLAIMER: Because of the generality of this update, the information provided herein may not be applicable in all situations and should not be acted upon without specific legal advice based on particular situations.
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the Washington Postcovers its namesake parent company's dismal second-quarter earnings report:
Washington Post Co. second-quarter profit up 13.6 percent
Here's how everybody else covers the Washington Post's erns:
Washington Post Profit Drops as Education Business Falters
Washington Post's Revenue Falls 5%
Education business, fewer print ads hurt Washington Post
Advertising, Circulation Declines at the Post
Washington Post loses $15.9 million in Q2
Only Dow Jones Newswires among major publications emulates the Post's house treatment of its earnings:
Washington Post Q2 net up 14% on fewer expenses
Are these just bitter competitors hating on a rival or did the Post (and Dow Jones) gloss its earnings? The latter. So how can one company make a profit in one headline but lose money in another?
The difference comes down to which accounting measure reporters and editors think should be emphasized on an earnings report. The Post goes with net income attributable to common shareholders, which indeed rose 14 percent last quarter. Bloomberg goes with net income from continuing operations, which dropped 29 percent, consigning the Post's headline number to the eighth paragraph (Politico is focusing, somewhat confusingly, on the Washington Post newspaper division only, which indeed lost $15.9 million in the quarter).
It turns out the Post Company sold two businesses in the quarter, which accounted for the entire increase in its profit and then some. Bloomberg went with net income from continuing operations because that gives readers and investors a better picture of the ongoing health of the company. You can only sell so many of your assets, after all, and doing so may increase your cash position, but it lowers future revenue and operating profit.
The Post's angle would have you believe the company had a good quarter. It did not, which is why Bloomberg et al. are better here. Dow Jones's piece, meantime, is just misleading. Its lede says that "Washington Post Co.'s second-quarter profit rose 14% as fewer operating expenses masked lower revenue, and the newspaper-publishing and education segments posted weaker results." Again, the increase in its profit was entirely due to selling two businesses.
The Post's overall revenue dropped 5 percent, its operating profit dropped 26 percent. Its one-time cash cow Kaplan education division saw its revenue drop 9 percent—worse even than newspapers—and its operating profit fall 84 percent. The paper lost nearly one in ten of its daily readers in the first half of the year. Even its cable TV division didn't do very well, with sales up just 2 percent and operating profit down 5 percent.
The only division that did well was the Post's TV unit, which saw sales rise 13 percent and operating profit jump more than a third. Unfortunately, that's by far the Post's smallest division and much of that good news was due to cyclical campaign advertising.
If there was good news in newspapers, it's that digital ads returned to positive territory.
While the Post does point out the continuing operations number in the third paragraph and reports most of the other negative news that or one of the negative numbers should have been the headline. When you're covering yourself, it doesn't look good when you're the outlier on your angle.
The New York Times, meanwhile, was boosted by its digital subscriptions, which the Post refuses to implement. The NYT newspaper saw its revenue rise 2 percent in the second quarter and its division's operating profit jump 78 percent.
Related articles
- Washington Post Profit Drops 29% as Education Business Falters – Bloomberg (bloomberg.com)
- Washington Post Co. second quarter profit up 13.6% (jimromenesko.com)


text:
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Bloomington area Invisalign® dentist Luke Eades, D.D.S. is happy to provide your new clear braces. At K Luke Eades, D.D.S, we want you to have the straight teeth and beautiful smile you desire.
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8028 E 10th St, Suite C
Indianapolis, IN 46219
If you're interested in natural-looking bridges and dentures, look no further than Miles Schroeder, D.D.S. who practices in the Indianapolis, Indiana area. Using modern materials and techniques, Dr. Schroeder can achieve the natural look you seek. You will be very pleased with the comfortable, long-lasting results.
Indianapolis area dentist Dr. Miles Schroeder offers dental payment plans so you can afford the treatment you need. Just talk with our friendly team about your needs.
We'll be happy to work with you to find the solution that fits your situation. We're committed to making your oral health a reality.
Dr. Miles Schroeder at his Indianapolis area cosmetic dentistry practice offers extensive experience restoring your dental implant crown.
Our dedicated team uses state-of-the-art materials and techniques for stability and longevity. You'll enjoy the comfort and confidence of natural-looking teeth.
129 N Van Rensselaer St PO Box 27
Rensselaer, IN 47978
In order to maintain your oral health, it's important to schedule regular dental check-ups. Don't wait until something is wrong to make an appointment with Rensselaer area dentist Dr. Jordan Balvich. At Jordan J. Balvich, DMD, PC, we provide comfortable and thorough checkups. By catching and correcting a potential dental problem early, Dr. Balvich can save you vast amounts of time, discomfort, and expense.
For comfortable dental hygiene treatment in the Rensselaer, Indiana area, Dr. Jordan Balvich is known for having a gentle touch. The friendly team at Jordan J. Balvich, DMD, PC provides teeth cleaning for a whiter smile.
Maintaining good dental hygiene is the foundation for healthy teeth and gums. We're committed to helping you have a lifetime of oral health.
Rensselaer area cosmetic dentist Jordan Balvich, D.M.D. has extensive experience creating beautiful smiles. They're one of the first things people notice about you.
Our professional team will be happy to discuss your aesthetic dentistry options. The attractive results you'll get from Jordan J. Balvich, DMD, PC can change your life!
You've probably heard that a root canal procedure can be an uncomfortable experience. At Jordan J. Balvich, DMD, PC, located in Rensselaer, IN area, that's not the case. Dr. Jordan Balvich numbs the tooth so you simply won't feel any pain, and you'll find that there is very little discomfort afterwards.
Don't let untreated dental problems get you down. Rebuild your confidence with a beautiful new smile. From simple treatments that make a big difference, to more extensive work, unveiling the smile you were meant to have can have profound life-changing effects. Serving the Rensselaer, IN area and offering cosmetic dentistry, Dr. Balvich can help you develop an affordable treatment plan you'll feel good about.
Oldag, Thomas G D.D.S.
4640 W Jefferson Blvd
Fort Wayne, IN, 46804-6826
Van, Mindy M D.D.S.
9002 N Meridian St # 201
Indianapolis, IN, 46260-5350
Stuart, Kathryn G D.D.S.
13590b N Meridian St # 104
Carmel, IN, 46032-1409
Aslin, Michael P D.D.S.
112 E Alto Rd
Kokomo, IN, 46902-3601


text:
"Rock and menopause do not mix. It is not good, it sucks and every day I fight it to the death, or, at the very least, not let it take me over."
Stevie Nicks
"We can fight with our destiny ...but one day you should be ready to admit it , surrender to it .....ok there is no ultimate failure or success..."
Basil C S
"i had my first hot flash yesterday and was told by a good friend that Merlot and coffee help....well.....menopause may not be that bad after all!"
Anjie Henley
"We were exploring whether or not fish have the equivalent of mammalian menopause. We found that 60 percent of the fish had a significant post-reproductive lifespan, indicating that, yes, fish do have menopause. Indeed, their patterns of growing old are similar to those of mammals."
David Reznick
"It's related to the aging process and menopause, ... The menopausal process takes five to 10 years, during which there's a progressive decline in estrogen, weight increases, blood pressure goes up, and cholesterol levels change."
Martha Hill
"It's related to the aging process and menopause, ... The menopausalprocess takes five to 10 years, during which there's a progressive decline inestrogen, weight increases, blood pressure goes up, and cholesterol levelschange."
"What we showed is that for the surgery to be a risk factor, it has to be done before menopause. If before age 46 you remove two ovaries, you get a 70 percent increased risk of dementia. And we discovered that women who have only one ovary removed before age 38 -- this is a surgery more often done in younger women -- we see a 260 percent increase in dementia. That is quite a dramatic and somewhat unexpected finding."
Walter Rocca


text: Infinity Blade Is the Only iPod and iPhone Game I WantJesus Diaz11/07/10 11:45pmFiled to: iosInfinity bladeEpicunreal engineEpic citadelVideoClips195EditPromoteShare to KinjaToggle Conversation toolsGo to permalink Remember Epic Citadel and the "Project Sword" combat demo shown by Epic Games? That game's official name is Infinity Blade. Its unofficial name is Fucking Hell Gimme This Game On My iPad Now Now Now. NOW, goddamnit. Here's the new trailer. The trailer looks as amazing as the demo. The game was developed by Epic's subsidiary Chair Entertainment using their Unreal Engine 3, and will debut this holiday season for iPhone, iPad and iPod touch, supposedly optimized for A4 processors. My credit card is itching as much as my fingers, although perhaps for different reasons. [Thanks Jorge!]Reply195 repliesLeave a reply


text:
Top Definition
1.The congregation of 6 or more niggas in one dorm room
2. too many niggas in one area
2. too many niggas in one area
1.Aight nigga limit one of yall gotta go!
2.there is a nigga limit dude so u can't come in.
2.there is a nigga limit dude so u can't come in.
by OU Kid
March 14, 2009
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text:
Mega-all Materia:In the North Cave, after you beat Sephiroth, head to the part of the cave with blue rock and green waterfalls. In one of the waterfalls you should see a little pink dot. Head over there, wait for it to come up, jump, and press X until you grab it. It lets you use "all" on every action you perform. Nice!
Quick Money II:At the Gold Saucer most attractions require you to have GP. Once you have entered by shuttle, go to the top left-hand corner to the save point. At the house to the right there is a chance that there will be a dark figure. He will sell you 100 GP for 10,000 gil...
More Easy Gil: In the cave before Sephiroth, there is a room with a bunch of roots around. In this room, you can fight little orange bouncy guys called "Movers". They have fairly low HP, and don't do much damage. But, for defeating them, you get a whopping 90,000 gil!
Final Attack Materia:Go to the Battle Arena in the Golden Saucer. If you haven't, save enough points and buy Omnislash and the W-Summon materia. At the point, you should be able to talk to the lady and enter a 'special battle'. These monsters are much harder, so be prepared. When you do win, you'll get the Final Attack materia as a prize. You may also receive other items, just so you know.
Item Duplicator Trick:You only need the W-Item Materia. During a battle, have the character with W-item pick a highlighted item that you want to duplicate. Then pick any other item. When the cursor is over a character, press "cancel" and your first item will increase to its original number. Then, press "accept" and then "cancel" over and over until you have 99 of the item.
Easy 2 Mega-Materia:In the final dungeon when you are prompted to take your party to the left and right path... take your party to the right path thus leaving the rest to go to the left. Follow the path down to the end where you meet up with the rest of the group. You can take the path that leads to where the party went left - do it and collect all the items from the left path. Now return to the group. They will hand over the items that they found on the left path (which are the same items you got).
Tetris Elemental:South of Cosmo Canyon is an island you can barely or maybe not even see on the world map. But this small little island is filled with Cactrots. Be sure you have the Morph Materia equipped along with a weapon with a good attack%. Go to battle and you will encounter a Cactrot. The Cactrot has 6,000 HP so take off atleast 5,800 to 5,900 damage points, then use Morph on it. If you don't hit him the first time with Morph then just keep on trying because most likely you will hit it with Morph. You now have a Tetris Elemental. Keep on doing this over and over again and you will get this rare relic.
Raise XP and Materia levels quickly:To raise your XP and Materia levels very quickly, simply go to the town of Junon (The town with the big cannon). Pay the man at the elevator 10 gil to enter. Once you reach the top, go the way that you would go to reach the underwater reactor. When you enter the hallway with the Shinra troops doing the marches led by the man in Red you will see a Red light on the wall. Go up to the light and press the Circle button or X and an alarm will go off. Run around the hallway but do not exit it! You will begin to fight a majority of enemies who are not very hard but will give you large amounts of XP and AP.
Slow down the Slots:In the battle square when the slot machine is going around to pick your handicap tap Square really fast and the slot will slow down.
When fighting bosses, combine Final Attack materia and either Pheonix Summon Materia or a Revive Spell Materia on master level. If you die you resurrect. Great for Sephiroth, Ruby, and Emerald.
When in the Chocobos Race, hold L1+L2+R1+R2 for extra speed and hold R1+R2+X to keep speed up and not lose any stamina.
Against the boss Gi Natakk, all you have to do his give HIM an X-potion or a Phoenix Down. This automatically drains all of his HP and you win the battle.
Underwater CaveThis can be done only once you have acquired the submarine. Board the submarine and go to the sea northeast of the Gold Saucer where the river meets the ocean. Submerge, and you will find yourself in a cave in the bottom of the ocean. You will notice that in the and of the cave there is a crashed airplane. It's Shinra's cargo plane. It's not very big, so search all of it and you will find many items.
Easy EXP and AP:An easy way to gain EXP and AP is to go to the upper path in the left path of the crater. In here, you will find creatures called Magic Pots. Each Magic Pot is worth 8,000 ep and 1,000 ap. However, there is one catch. If you try to attack them, you will do zero points (physical or magical). They will also say "Gimme Elixir!" So you must give them an Elixir. This will allow you to do damage to them.
Gold Chocobo:To raise a Gold Chocobo, you will have to breed a variety of others to get the desired product. You will first need the Chocobo lure to capture them. Once you have it, rent out six stalls at the Chocobo Farm. Each stall will run you 10,000 gil, so be prepared to shell out a lot of money. Now the first two Chocobos you need are a Running female and a Walking male. The Walking male can be found near the Gold Saucer, while the Running female is just west of Mideel. Capture two of them and then head back to see what you've caught. Choco Billy will rate each one you bring in. Be sure that you get a "good" Walking male and a "great" Running female. This is a good time to save your game. Head to the plains below Bone Village and steal Carob Nuts from the Vlakorados' (3 Carob Nuts needed). Now return and mate these two using a Carob Nut. Keep resetting until you come up with a Green and Blue Chocobo of opposite genders (either combination will work). You can use the same two Yellow Chocobos to breed again, but you will need to give them some time after a successful mating. Once you have the Green and Blue Chocobos, feed each of them 10 Sylkis Greens (See Chocobo Sage) and head off to the Golden Saucer to race. All of the initial Chocobos you get will be C-Class and will need to be advanced to A-Class (Tip: When racing, hold R1 + R2 to keep your Chocobos stamina up). Return once again to the farm and mate them together with another Carob Nut to get a Black Chocobo. Head to the snow-covered Northern Continent and look for the tracks on the western shore. Here you will find the Dashing Chocobo. Make sure it is in the "wonderful" quota and is the opposite gender of whatever your Black Chocobo is. Feed these newest Chocobos 10 Sylkis Greens each and race them both up to A-Class. At this point you will need to go to an island to the northeast of the Chocobo Farm. You will need to battle with the goblins there to receive a Zeio Nut. With any luck, when you return and use it to mate the Dashing and Black Chocobos, you will get a Gold Chocobo!! The Gold Chocobo gives you access to any place you want to go on the map.
Knights of the Round Summon Materia:To get the Ultimate Materia, you will require a Gold Chocobo. Head North of the island with Goblins on it, to an invisible island that can't be seen on the tiny map, even when it's enlarged! Head into the cave there and the Knights-Of-The-Round Materia is yours! This materia takes a surprising total of 60,000-70,000 HPs off all enemies!
Stable 1 Color 300934B70004 Quick Limit Bar Gain In Battle d00a14505e68 800a145000ff d00a14529422 800a14522402 Debug Mode 8009a05c0041 8009abf60041Infinite Gil 8009d260ffff Quick Level Gain 8009d7d8ffff
Start the Game With W-Summon 8009D0C4 0014 Start the game with Master Summon 8009D9A0 005A Save Anywhere 8009D2A6 0000 Limit Break every turn for first character 800F5E6A 00FF Limit Break every turn for second character 800F5E9C 00FF Limit Break every turn for third character 800F5Ed2 00FF Always get 65535 EXP points after battle 8009D7D8 FFFF Always get 50000 AP Point after battle 8009D7DC C350 No Random Battles 8007173C 0000 No Random Battles on the World Map 8011627C 0000 All characters to level 99 (use after battle) 801FFDD6 0100 8009D7DA 0100 Max out Materia in first slot 8009CE62 0100 Cloud's HP 9999 8009D85C 270F 8009D85E 270FAutomatic Replenish Slot 1 800F840C 270F Always have 9999 HP for Tifa 8009DC9C 270F 8009DC9E 270FAuto Replenish Slot 2 800F8474 270F Always have 9999 HP for Barrett 8009E0DC 270F 8009E0DE 270FAuto Replenish Slot 3 800F84DC 270F Cloud has all possible Limit Attack 8009C75A 0FFF Tifa has all possible Limit Attack 8009C862 0FFF Barrett has all possible Limit Attack 8009C7DE 0FFF Yuffie has all possible Limit Attack 8009C9EE 0FFF Red XIII has all possible Limit Attack 8009C96A 0FFF Aerith has all possible Limit Attack 8009C8E6 0FFF Cid has all possible Limit Attack 8009CB7A 0FFF Vincent has all possible Limit Attack 8009CAF6 0FFF Cait Sith has all possible Limit Attack 8009CA72 0FFF Have 9999 Gold Points at the Golden Saucer 8009D3D2 270F Have 50000 Battle Points at the Golden Saucer 8009D3D8 C350 Infinite life for Cloud 8009C764 270F Infinite MP for Cloud 8009C768 03E7 No Monsters 80070674 0000 801160C0 0000Turn any growing Chocobo into a Gold Chocobo 8009BC4E 0400


text:
'48 trimmed dash high and wide
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- Tractors Owned: '48 trimmed dash high crop cub, '78 3/4 cub , lo-boy , cub-6 toolbar, mowers, 54 blade, disc.
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Re: '48 trimmed dash high and wide
yogie , you know things in the deep south can be a bit fast and loose . guys , thanks for all the info and ideas . upon looking at it closer yesterday its not too bad . one thing i did not mention and should have, the original '48 bolster that came with it was like john was talking about, it had a freeze HEAVE . a straight edge across the radiator mounting surface touched it in the middle , and had a gap at the edge about 1/2" on each end of the mounting surface. i had another bolster that was an "S" casting that looked good. all the mounting holes were fine, even the dog leg holes . then i started cleaning with the sidegrinder wirewheel , and the weld showed up . its probably a bit silly , but i want to do this one with the extra effort put in to her, it will be the only one i build , more than likely . i wasnt too keen on using the "S" , so the weld sealed its fate . i'd really like to get a 5-( )-R cast date bolster or a few months either way . more pictures today , i'll be able to slip down to the shop for a few hours today , thanks again guys, coppersmythe.........................................one other aspect , all the cast codes "match", within a few months , i just gotta try to find one.
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text: Christina Whitman, '74, is the Francis A. Allen Collegiate Professor of Law and a professor of women's studies at the University of Michigan. From 2009 to 2014, she served as U-M's vice provost for academic and faculty affairs. She is chair-elect of the Law School Admissions Council Board of Trustees. Her research interests include federal courts, constitutional litigation, torts, and feminist jurisprudence, with a particular focus on questions of personal and institutional responsibility. From 1997 to 2001, Professor Whitman served as associate dean for academic affairs for the Law School. From 2005 to 2007, she was special counsel to the provost for the policy on conflicts of interest/conflicts of commitment. A former editor-in-chief of the Michigan Law Review, Professor Whitman holds three degrees from the University of Michigan, including a law degree and a graduate degree in Chinese literature. She joined the Michigan Law faculty in 1976, after serving as law clerk to the Hon. Harold Leventhal of the U.S. Court of Appeals for the District of Columbia Circuit and to Justice Lewis Powell of the U.S. Supreme Court. She is the recipient of the 2014 L. Hart Wright Award for Excellence in Teaching.


text:
Kingdom | Phylum | Class | Order | Family |
Plantae | Tracheophyta | Liliopsida | Orchidales | Orchidaceae |
Scientific Name: | Masdevallia atahualpa |
Species Authority: | Luer |
Synonym(s): |
Brysella atahualpa (Luer) Luer
Red List Category & Criteria: | Endangered B2ab(iii) ver 3.1 |
Year Published: | 2013 |
Date Assessed: | 2013-02-06 |
Assessor(s): | Chadburn, H. |
Reviewer(s): | Rankou, H. |
Justification: This species has been listed in the Red List of the Endemic Plants of Peru (Roque and Leon 2006) as Endangered citing criteria B1ab(iii). It was not found within protected areas and there are undoubtedly threats to the habitat within its range from deforestation with the expansion of agriculture. This would lead to a decline in the extent and quality of habitat. It is difficult to calculate the extent of occurrence (EOO) as only two herbarium specimens with suggested locality were found. Although there is some uncertainty about specific locality detail the number of locations is inferred to be less than five. It seems likely that the area of occupancy (AOO) approaches, and seems likely to fall below, the 500 km2 threshold and this would lead to an Endangered rating. It is, therefore, with these inferences, assessed as Endangered. However, further surveys are needed to establish the current population status and geographic range to verify this rating. |
Range Description: | This orchid has been found in Amazonas Province in Northern Peru. Only two specimen collections were found both from the southern part of the Province in the Leimebamba-Balsas and Chachapoyas Districts. | ||||||||
Countries occurrence: | Native: Peru | ||||||||
Additional data: |
| ||||||||
Range Map: | Click here to open the map viewer and explore range. |
Population: | The current population status of this species is not known. |
Current Population Trend: | Unknown |
Additional data: |
Habitat and Ecology: | This is a large tufted epiphytic orchid. It is reported to prefer cool growing conditions (Gerritsen and Parsons 2005) and to be found at an altitude of 3,000-3,100 m asl (Roque and Leon 2006). |
Systems: | Terrestrial |
Continuing decline in area, extent and/or quality of habitat: | Yes |
Use and Trade: | This species is grown by orchid enthusiasts and may be subject to collection from the wild. |
Major Threat(s): | The areas where this species has been recorded are subject to agricultural development and forest reduction. The high recorded altitudes for this species may afford it some protection. However, felling for timber may possibly pose threats to this epiphytic orchid. It is also possible that it may be subject to collection from the wild as it is grown by orchid enthusiasts and such collection has been known to occur with other orchid species in Peru (Tasker 2009). |
Conservation Actions: | The specimen collections that were found were not made from within protected areas. It is recommended that new areas for protection are identified and existing areas extended. This species is, however, listed in appendix II of CITES, intended to give protection from trade incompatible with species survival in the wild. Further research is needed into the ecology and habitat requirements of, and specific threats to, this orchid to determine its conservation needs. Surveys are needed to establish the current population status and confirm the geographic distribution. Subsequent monitoring to detect any decline is also recommended. Although cultivated by orchid enthusiasts it is not known to be held within a botanic garden and it is recommended that, if possible, seeds are also stored as part of ex situ conservation measures. It is also recommended that further taxonomic studies are undertaken as Luer (1982) notes that this species is closely allied to many others in its section (Coriacea). |
Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES). 2007. Appendices I, II and III. Available at: www.cites.org/eng/app/appendices.shtml. (Accessed: 16 August 2007). Gerritsen, M.E. and Parsons, R. 2005. Masdevallias. Timber Press, Portland. IUCN. 2013. IUCN Red List of Threatened Species (ver. 2013.1). Available at: http://www.iucnredlist.org. (Accessed: 12 June 2013). Luer, C.A. 1982. Miscellaneous new species and combinations in the Pleurothallidinae (Orchidaceae). Selbyana 7(1): 102. Roque, J. and León, B. 2006. Orchidaceae endémicas del Perú. In: B.León, J.Roque, C.U. Ulloa, N. Pitman, P.M. Jørgensen and A.Cano (eds), El libro rojo de las plantas endémicas del Perú, pp. 759-878. Facultad de Ciencias Biologicas, Universidad Nacional Mayor de San Marcos, Lima. Tasker, G. 2009. The State of Orchids in the Wild Brought Home. Coral Gables Available at: http://www.fairchildgarden.org/livingcollections/GeorgiaBlog/id/191/read/The-state-of-orchids-in-the-wild-brought-home/. |
Citation: | Chadburn, H. 2013. Masdevallia atahualpa. The IUCN Red List of Threatened Species 2013: e.T42831258A42832478. . Downloaded on 28 March 2017. |
Disclaimer: | To make use of this information, please check the <Terms of Use>. |
Feedback: | If you see any errors or have any questions or suggestions on what is shown on this page, please provide us with feedback so that we can correct or extend the information provided |


text:
2011-07-06 / Arts and Entertainment
'Beacon Perspectives' Group Photo Show
To celebrate its 8th anniversary, RiverWinds Gallery is featuring a group photography show, "Beacon Perspectives," from July 9 to August 7. The show, which consists of images of the city of Beacon and its environs, will be at both RiverWinds Gallery, 172 Main Street, and at the Howland Center, 477 Main Street, Beacon.
The full version of this story is available only to subscribers. Subscribe now to access to full versions of news stories in our archive of over 12,000 stories going back to 1999.


text:
You have discovered the portal to one of the most romantic, unique and charming stores in Southern California. Le Potager is a fine European home and garden store located in the city of Fullerton.
Our historical 1918 two-story home holds a wide range of decorative furnishings including antiques, furniture, home & garden décor and gifts. Le Potager creates stunning custom designed displays and features seasonal vignettes using antiques, vintage and new items to achieve one of a kind looks.
To acquire the beautiful Le Potager "look" in your home or garden, call us for an in-home design consultation for interior, garden, special events and/or holiday designs. We specialize in re-creating our European inspired style, both inside and outside.
Established in 2000, featured in many publications and voted: ● 1st Place - Best Gift Store (2010) My Fox LA's Hot LIst ● 4th Place - Best Home Goods (2011) My Fox LA's Hot List ● Top 3 - Best Home Furnishings (2011) Orange County Register's Best of Orange County. ● 1st Place - Best Home Goods (2012 & 2013) Orange County's Hot List Le Potager is a "must visit" in Historic Downtown Fullerton. | ||
"It is, without a doubt, the most uniquely regal and romantic shop of its time." - CityVoter | ||
Click for Special Events Page | Store Hours | ||
We hold many events throughout the year and this is where we'll show you what's coming up. Specials...savings...food... demonstations & more. Be sure and join us for our special events. |
| Home | Calendar | Testimonials | Publications | About Us | Contact Us | Auction | | |
Website designed and maintained by Art Matters ©Copyright 2010 Le Potager Decor - Reproduction of any part of this website is prohibited |


text:
19450 Surnames | 123929 Records | 2651 Reunions
Dead Fred asks:Are you a Desperate Genealogist? Click the e-book above for details!
Dead Fred's Genealogy Photo Archive, a free, fun photo genealogy research web site devoted to helping you visualize your heritage!
Photo Thumbnail Click image for larger view.
Order The Desperate Genealogist's Idea Book: Creative Ways to Outsmart Your Elusive Ancestors (eBook).You can also order The Desperate Genealogist's Idea Book in hardcopy format by clicking here.
Photo #81877
Last Name: Kemper
First Name : Danny
Middle Name:
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Subject's Country:
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Nee: Kemper
Type** : GRP
Comments: Danny Kemper (Nee: Kemper) | | | Comments: This was found in a purchase I made from an auction. The children listed in the photo are: Kathy, Liz, Peggy, Mary and Danny Kemper. The parents are Jean and Dan Kemper. I believe it to be a Christmas Card. The date on the back says 1956
Digital Image Only? NO
Everyone Listed In This Photo:
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text:
You know when you go to shows or festivals with the hope that some of the artists on the bill will perform their collaborations together onstage? Well, it's probably not that likely that folks at the SWU Music & Arts Festival in São Paulo, Brazil yesterday were hoping to hear Fergie do her feature on Kanye West's "All of the Lights." But that's exactly what went down and from what we've been reading, it's actually the first time they ever performed the song together live. Interesting. You can watch it all go down below, where you can also catch Yeezy running through "Stronger." [Miss Info]
Body Language - "Holiday" (RAC Mix) | DJ Premier Heavy D Tribute Mix |


text:
FREE Webinar: DARE to be a Successful Project Manager
While projects usually start with good intentions and lots of enthusiasm, it's sometimes difficult to maintain that focus and energy when you have to juggle multiple priorities at the same time. No longer just the responsibility of those trained as project specialists, the ability to manage everyday projects is a requirement for many people in today's organizations. Join author and project management expert Lou Russell for an hour-long session that will address common stumbling blocks and offer you a practical formula for success.
What You Will Learn
- What it means to manage everyday projects
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- A method for managing projects that's both flexible and repeatable
Who Should Attend
- Managers
- Supervisors
- Team Leaders
- OD Consultants
- Trainers
About the Presenter
Lou Russell is president and CEO of Russell Martin & Associates. She is the author of The Accelerated Learning Fieldbook, Project Management for Trainers, IT Leadership Alchemy, Leadership Training, and 10 Steps to Successful Project Management. She is a frequent contributor to Computer World, Cutter Executive Reports, and Network World, among others, and publishes the monthly Learning Flash electronic newsletter.
A popular speaker, Lou addresses national and international conferences such as the Project Management Institute, Project World, and LotuSphere. She holds a computer science degree from Purdue University, where she taught database and programming classes, and a Masters in Instructional Technology from Indiana University.


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We have sold this bulk now for years and decided it was time to avoid confusion and supply the diff and hardware to avoid any issue in trying to get your Maxx in bullet proof condition.
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Cameron Diaz vs. Jennifer Lopez Fashion Face-off
By Molly McGonigle
Both Cameron Diaz and Jennifer Lopez know what it takes to remain relevant in Hollywood -- hot bodies and bankable talent. With more than two decades in the biz, both women have also carved out their unique fashion niches. We face off these glamour queens to let you decide who has the better style.
Both of these ladies know that sometimes there's nothing sexier than a backless dress for a fancy night on the town. At the recent Costume Institute Gala at New York's Metropolitan Museum, Cameron opted for a beaded, 20-pound Stella McCartney gown that showed off her muscles, while at the 2012 Academy Awards, Jennifer rocked a glittery Zuhair Murad that sexily showed lots of skin.


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Blommersia Dubois, 1992
Blommersia Dubois, 1992, Bull. Mens. Soc. Linn. Lyon, 61: 311. Type species: Gephyromantis blommersae Guibé, 1975, by original designation. Proposed as a subgenus of Mantidactylus.
Blommersia — Glaw and Vences, 2006, Organisms Divers. Evol., 6: 242. Rank of genus.
English Names
None noted.
Suggested by Glaw and Vences, 2006, Organisms Divers. Evol., 6: 236-253, and Kurabayashi, Sumida, Yonekawa, Glaw, Vences, and Hasegawa, 2008, Mol. Biol. Evol., 25: 874-891, to be the sister taxon of Guibemantis. This was confirmed by Wollenberg, Vieites, Glaw, and Vences, 2011, BMC Evol. Biol., 11 (217) : 1-15. Glaw and Vences, 2007, Field Guide Amph. Rept. Madagascar, Ed. 3: 184-187, provided accounts. Vences, Köhler, Pabijan, and Glaw, 2010, Afr. J. Herpetol., 59:: 137, provided a molecular tree of relationships. Pyron and Wiens, 2011, Mol. Phylogenet. Evol., 61: 543-583, provided a molecular tree based on Genbank sequences that largely confirmed earlier studies.
Contained taxa (10 sp.):
External links:
Please note: these links will take you to external websites not affiliated with the American Museum of Natural History. We are not responsible for their content.
- For additional sources of information from other sites search Google
- For images search Arkive, CalPhoto Images and Google Images
- To search the NIH genetic sequence database, see To search the NIH genetic sequence database, see GenBank


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Lot 951: Femaru Model 37 semi-auto pistol, 7.65 cal.,
Firearms, Coins, hard Assets and Collectibles Auction
by Little John's Auction Service
August 26, 2010
Anaheim, CA, USA
Past Lot
Looking for the realized and estimated price?
Description: Femaru Model 37 semi-auto pistol, 7.65 cal., 3-3/4" barrel, black military finish, nazi proofed, grooved wood grips, #50724. This gun is in overall very good condition showing approx. 95% brush military black finish with high point wear and loss confined primarily to a small area under the barrel at the muzzle, very good bore, crisp action, sharp markings, good grips with a couple compressions on the left bottom portion of the grip; bottom of magazine marked "P. Mod 37".
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Brewers spring training report: Thursday at a glance
On the field: Pitchers and catchers continued to do the majority of the work in advance of Saturday, when the first full-squad workout takes place. In addition to throwing bullpen sessions, pitchers also did some hitting in the cages and took to the diamond to practice base running. Ryan Braun and Carlos Gomez also reported, leaving Aramis Ramirez as the lone prominent member of the roster to have not shown up in advance of Friday's mandatory report date for position players.
Cactus juice: On most days, there is only a small gathering of media members who take part in manager Ron Roenicke's morning briefing. On Thursday, with word Braun was expected to arrive, there were more than 20, along with multiple TV cameras, jammed into Roenicke's smallish office. As everyone filed in, Roenicke looked up from his desk and jokingly asked, "What's up, guys? Something going on today?"
Weather: 75 and mostly sunny.
Scoreboard: The Brewers begin their Cactus League season Feb. 27 on the road against Oakland.
Countdown: 38 days until opening day, March 31, against Atlanta at Miller Park.
Todd Rosiak


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Malta Decorative Glass Co. The glass factory only proved to be a show place. Mr Boffo was seconded to work there and train boys or leave Malta and he worked for the government for as long as it survived. It was the end of his glass-making days â very sad.


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Without much warning, Will Sheff and the guys of Okkervil River have released their second Golden Opportunities EP/mixtape project. It serves as the free downloadable follow-up to 2007's first Golden Opportunities, which featured eight covers and one live original track. For the second installment, Sheff and company whittled down their track listing to a mere five tunes, all of which are covers that were recorded live to a two-track in Austin. You can download Golden Opportunities 2 here and view its track listing below.
The Starlight Girls - "Wasteland" | Guided By Voices "Over The Neptune/Mesh Gear Fox" (Live In London '96) |


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May 9th, 2008, 05:52 PM | #1 |
not Frank Sinatra
Pagan Religion?
Why are pagan religions not more common today? I mean, they are the oldest form of religion which logically makes them more credible. Their claims are no more impossible than those of Christianity, Islam, Buddhism, Judaism, etc...
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May 9th, 2008, 08:15 PM | #3 |
Redneck Poser
I suspect it is because of the negative light that has been brought on it in the past. Wicca being refered to as witchery and associated with witchcraft. People have been taught that Wiccans are satanic and anti-christian as opposed of being taught that the religion is pre-christian and christianity has drawn many beliefs from pagans.
May 9th, 2008, 08:18 PM | #4 | |
Custom User Title
It is the same thing with atheism. People call atheists "devil worshippers", when how can you worship the devil if you don't beleive in him? People forget that the devil only exists where god does. |
May 9th, 2008, 08:23 PM | #5 | |
Redneck Poser
I was working with my uncle doing an insulation job once and he started preaching to me as he normally did. This is a guy that has openly cheated on his wife his entire life. He was a drunk and most interesting he was very decietful, often times moving into an apartment and paying the securities and never paying another cent until he was evicted. Anyhow, my uncle told me I would burn in hell with the devil for not being a believer. He turned white as a ghost when I pointed that out to him. |
May 9th, 2008, 09:42 PM | #8 |
Mr. Special Snowflake.
May 10th, 2008, 12:29 AM | #9 |
not Frank Sinatra
May 10th, 2008, 12:34 AM | #10 |
not Frank Sinatra
what are you basing this on? There is as much or more evidence supporting many of these faiths as Christianity, Islam, Buddhism, Hinduism, and other mainstream religions.
btw the bible is not usable evidence against these faiths as most of them have just as many written accounts supporting their existence. |
May 10th, 2008, 07:47 AM | #11 | |
web wheeling, hard.
What specifically makes the claims of pagan religions equally credible to to story of Christ? What specifically would make them more of a logical belief? |
May 10th, 2008, 08:10 AM | #15 | |
In the band!
So pagan is used more like a generic term for poly religions. But they are everywhere. But like an earlier post said, they have been oppressed so they keep only to them selves and do not openly practice. it is even still oppressed today. I know that the Detroit Schools were sued over allowing one openly Wiccan girl to be persecuted on school grounds to the point where she committed suicide. Oh, FYI, My mom has a doctorate in Comparative Religion |
May 10th, 2008, 08:17 AM | #16 |
In the band!
i am a big fan of the pagan religions. norse gods and greek/roman gods were a bunch of sons a bitches, but if you read the old testament they were a bunch of bastards also. jesus, was supposedly the son of god, Hercules was also the son of a god. they both did often courageous acts to help people.
May 10th, 2008, 08:38 AM | #17 |
Wheelin the HD
so your mom is a nut that compaires nuts cases?
the praticing wicans I know are not really that knowledgable, witch might be another reason that they don't preach, and anyone that is knowledgable probably spends too much timee answering everyone eles questions. that or they jut don't want to be associated with christianity by preaching... the difference in religon? not really any, they still waste their time making up storys and worshiping unanswering gods. |
May 10th, 2008, 08:53 AM | #18 |
In the band!
May 10th, 2008, 10:41 AM | #19 | |
not Frank Sinatra
basically it is like that silly phone game kids play. The farther from the source of the message the more distorted it becomes. |
May 10th, 2008, 11:45 AM | #20 |
Mr. Special Snowflake.
I think the simple answer is that we don't follow pagan religions because our parents didn't. Most religious people prescribe to the religion of their ancestors. Some will claim to have studied many religions and picked one, but I think even most of them end up choosing the religion they learned of as a child.
As to why our ancestors chose to follow the more "modern" monotheistic religions rather then the "ancient" polytheistic religions we could probably debate that until the end of time. Dave Kerwin and friends will say that it's because the fact that their beliefs are based on writings of people that claim to have been eyewitnesses to the events on which the beliefs are based, whereas the ancient religions are based on legends of things that happened before the age of recorded history, or that happened in some "mythical" place beyond the view of humans . To them that makes their beliefs more credible and believable. 84Scrambler and friends will say/said that all religions are mythical legends, and that the only reason "modern" religions are more popular than ancient religions is that the religions that wrote nifty books, and marketed themselves better, sometimes with the point of a sword or gun barrel, became the dominate religion and the other simply died out as a result. Me, being the extreme moderate I am, believe the truth is somewhere in between. |
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PA Prospective Students
As indicated in our mission statement, the Union College PA Program prepares students from diverse backgrounds for excellence in the PA profession, developing their God-given abilities in harmony with the highest physical, mental, social and spiritual ideals.
Graduates of the program will further these qualities, as well as pursue the vision and goals of the program, as they move into clinical practice.
Union College offers a 33-month professional course of study, leading to a Master of Physician Assistant Studies (MPAS) degree. The program is fully accredited by the Accreditation Review Commission on Education for the Physician Assistant Inc.(ARC-PA), and graduates may sit for the Physician Assistant National Certifying Examination.
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NUMBER NERVOUSNESS People anxious about doing math use certain brain networks differently when doing arithmetic, which suggests they might use different problem-solving strategies than people who aren't anxious about math. XiXinXing/iStockphoto
DISEASE DEFENSE To control the spread of dengue in Bangkok, DDT is sprayed to kill mosquitoes, the primary insect that transmits the virus. PongMoji/iStockphoto
Science Ticker Ebola vaccine proves effective, final trial results show The Ebola vaccine rVSV-ZEBOV proved effective at stopping the spread of the virus in a clinical trial in West Africa.
News in Brief Ebola vaccine proves effective The Ebola vaccine rVSV-ZEBOV proved effective at stopping the spread of the virus in a clinical trial in West Africa.
The List For Ebola patients, a few signs mean treatment's needed — stat A few criteria may help identify Ebola patients who need the most care.
News Gastric bypass controls diabetes long term better than other methods Bariatric surgery outperforms other weight-loss measures in the longest-term study yet of diabetes outcomes.
News in Brief Math-anxious brains tackle simple problems differently An fMRI study found more variable brain activity in people who get nervous about math problems.
Editor's Note Lab tests aren't the answer for every science question Acting Editor in Chief Elizabeth Quill discusses the value of observational science.
News A good diet for you may be bad for me Eating the same foods can produce very different reactions in people.
Editor's Note Math offers new view of brain and its disorders Editor in chief Eva Emerson discusses new insights into the brain's role in mental illness, sleep, and ancient rituals.
News Fish oil may counter schizophrenia Three months of omega-3 fatty acids protects against psychosis for years, a small study suggests.
News Random mutations play large role in cancer, study finds Mistakes made while copying DNA account for more mutations in cancer cells than environment or inheritance do.
Feature Cancer cells cast a sweet spell on the immune system Tumors have surface sugars that persuade the body's defenses to look the other way. New therapies are being devised to break the trance.
Growth Curve Touches early in life may make a big impact on newborn babies' brains The type and amount of touches a newborn baby gets in the first days of life may shape later responses to touch perception, a study suggests.
Growth Curve See how bacterial blood infections in young kids plummeted after vaccines Rates of pneumococcal bacteremia in children plummeted by 95 percent after the introduction of vaccines against Streptococcus bacteria.
Growth Curve Don't put greasy Q-tips up your kid's nose, and other nosebleed advice Nosebleeds in children are common and usually nothing to fret about.
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French director. Film critics often see Robert Bresson as one of the best movie directors. However, his movies were definitely not entertainment but art. Indeed, after his two first movies, Les Anges du Péché (1943) and Les Dames du Bois de Boulogne (1945), he decided to use only non-professional actors, whom he called his 'models'.
This gave his movies an unusual yet fascinating austerity ; few filmmakers have so much applied Antoine de Saint-Exupéry's principle that "perfection is when there is nothing left to remove". As an example, most of the music in his movies comes from a visible source.
His best movies are perhaps Pickpocket (1959), about a pickpocket who finds redemption in love, and Au Hasard Balthazar (1967), a movie which tells the story of a donkey, but yet tells much about humanity.
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An aggressive, dynamic ball-carrier, the 31-year-old forward is known throughout the RaboDirect PRO12 as one of the hardest hitting tacklers in the game.
Although not the biggest member of the Connacht back row at 1.84m and 95kg, he regularly punches well above his weight.
A fans' favourite and part of the fabric that has moulded the current Connacht team, Ofisa earned his 100th cap for Connacht against Benetton Treviso earlier this season.
He has been part of some of the biggest matches in the province's history including the Heineken Cup pool match against Toulouse and South Africa's visit in 2007.
He was unfortunate to miss Connacht's clash against his native Samoa when they arrived in the Sportsground in 2010 and he will be fondly remembered by fans as one of the most unassuming gentlemen off the field and one of the province's greatest competitors on it.
"He is one of the quietest men in the squad but once he crosses the whitewash he can turn a match in a flash with a moment of brilliance.
"In his time here he has really bought into the ethos of everything we are about and I know Ray considers Connacht a family away from home.
"It's a credit to the man and his strength of character that even now he is finishing the season on a high and on behalf of myself, the management, the players and all our supporters I would like to wish Ray every success for the future."
In addition to Ofisa's departure the following five players have not been offered contracts by Connacht for the 2012/13 season - Henry Fa'afili, Dermot Murphy, Dylan Rogers, Jamie Stephens and Brian Tuohy.
Team manager Tim Allnutt added: "Following discussions with head coach Eric Elwood and his coaching team it was decided that these players would not be offered contracts for next season.
"On behalf of all at Connacht Rugby I would like to wish them all the very best of luck in their future careers and thank them for their professionalism and commitment whilst they were at Connacht."


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Where are you taking your classes?
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Welcome to
Baker is a private, liberal arts university that educates students through small classes, innovative instructors and rigorous coursework.
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Safety and Efficacy of Low Doses of V24343 in Obese Subjects
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- How to Read a Study Record
Randomised, double-blind, parallel group comparison of four dose levels of V24343 and placebo to study the effect of V24343 on blood pressure and weight in obese subjects.
The primary variables, change in blood pressure (BP) and pulse, will be assessed both by outpatient ambulatory monitoring of vital signs and by regular clinic monitoring.
The efficacy of V24343 will be assessed by measurement of body weight, waist circumference, bioimpedance assessment of body composition and blood glucose.
Assay of plasma concentration of V24343 in blood samples collected at intervals after dosing will be used to assess the pharmacokinetics of V24343.
Other safety assessments comprise routine monitoring of adverse events; concomitant medication; clinical laboratory safety tests, 12-lead electrocardiograms (ECG) and self-completed psychiatric assessments.
Condition | Intervention | Phase |
Obesity |
Drug: V24343 |
Phase 1 |
Study Type: | Interventional |
Study Design: | Allocation: Randomized Intervention Model: Parallel Assignment Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor) |
Official Title: | A Double-blind, Placebo-controlled, Parallel Group Study of the Effect of V24343 on Blood Pressure and Weight in Obese Subjects |
- To examine any effects of V24343 on pulse and blood pressure (vital signs) [ Time Frame: 24-hour on screening and pre-dose on Days 2, 26 and 56. Semi -recumbent and stand SBP , DBP and pulse, in duplicate at each time point. ]
- To determine if there is adequate differentiation between doses of V24343 associated with any effect on vital signs and those associated with efficacy (weight loss). [ Time Frame: Body weight and wasit circumference: screen and time-matched to pre-dose on Days -1, 8, 15, 22, 29, 35, 42, 49 and 56. ]
Enrollment: | 32 |
Study Start Date: | October 2008 |
Study Completion Date: | March 2009 |
Primary Completion Date: | March 2009 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
Experimental: 1
Randomised to a parallel group comparison of either one of four doses of study drug (1mg, 2mg, 5mg, 25mg) or placebo. Dosed once daily for 28 days
Drug: V24343
Oral, 1mg, 2 mg, 5 mg or 25 mg, or placebo, once daily for 28 days
Ages Eligible for Study: | 18 Years to 60 Years (Adult) |
Sexes Eligible for Study: | Male |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria: Subjects must:
- be healthy male subjects aged 18 to 60 years
- have a body mass index greater than or equal to 27 kg/m2
- have a waist measurement >94 cm
- have blood pressure (BP) within the ranges systolic BP (SBP): 90-150 mmHg; diastolic BP (DBP): 40-90 mmHg, based on mean of day time readings recorded during a 24 hour period of ambulatory monitoring:
- be willing to use an effective method of contraception (condom with a spermicidal contraceptive, or sterilised) for the duration of the study and for 3 months after the last dose of study medication
- have an acceptable medical and social history in the 12 months prior to screening
- be able to comply with the requirements of the entire study
- give written informed consent
Exclusion Criteria: Subjects must not:
- have received V24343 previously
- suffer from or have a history of anxiety or depression; have abnormal results on Patient Health Questionnaire 9 or Profile of Mood States (see Section 184.108.40.206)
- have a history of seizures (excluding febrile convulsions below 3 years of age)
- be male subjects whose female partners are trying to become pregnant within 3 months after the last dose of study medication
- have a significant medical condition or a history of such a condition that the Investigator considers should exclude the subject from the study
- have multiple drug allergies or be allergic to any of the components of V24343 study medication
- be smokers whom smoke more than 10 cigarettes per day
- consume more than 28 units of alcohol per week, or have a significant history of alcohol abuse
- have a positive test for alcohol or drugs of abuse at screening or admission to any of the treatment periods
- have donated blood or plasma in excess of 500 mL within 3 months of screening
- have been exposed to any new investigational agent within 3 months prior to study drug administration
- have clinically significant abnormalities on laboratory screening tests, particularly liver function and renal function tests (see Section 18.104.22.168)
- have clinically relevant abnormal physical findings on examination
- have clinically relevant abnormal findings on 12-lead ECG including a mean QTcB at screening ≥430 msec
- be seropositive for hepatitis B, hepatitis C or human immunodeficiency (HIV) viruses at screening
- have any medical or social reasons for not participating in the study raised by their General Practitioner/primary care physician
- have any other condition that might increase the risk to the individual or decrease the chance of obtaining satisfactory data, as assessed by the Investigator
- have had treatment with any prescription medicine within one month of first dose or any over-the-counter medicines, except for paracetamol, within one week of the first dose
Please refer to this study by its ClinicalTrials.gov identifier: NCT00734201
United Kingdom | |
Hammersmith Medicines Research | |
London, United Kingdom, NW10 7NS |
Principal Investigator: | Steve Warrington | Medical Director |
Responsible Party: | Steve Warrington, Medical Director, Hammersmith Medicines Research, |
ClinicalTrials.gov Identifier: | NCT00734201 History of Changes |
Other Study ID Numbers: |
V24343-1Ob-03 |
Study First Received: | August 6, 2008 |
Last Updated: | July 21, 2011 |
Keywords provided by Vernalis (R&D) Ltd:
Study effects on blood pressure and weight in obese subjects |
ClinicalTrials.gov processed this record on March 30, 2017