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Eye of Lupoku
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Eye of Lupoku | |
Durability | 25 |
Armor Rating | 137 |
Rarity | Unique |
Type | Buckler |
Requirements | Finesse 43 |
Effects |
This buckler was built for an owner that did not want to be caught in battle. In keeping with the theme of Lupoku, it seems designed to cause mayhem when struck.
- Blocks 76 Damage
- 10% Elemental Resistance
- 50% Chance to Burn enemies when attacked
- +1 to Finesse Abilities
Location Edit
Eye of Lupoku can be found randomly in chests or as loot.
- Even though it is a unique item, it can be acquired several times, even without respawning the Teeth of Naros region.


text: Where To Buy Features Key Features The world's first world-class competitive SU-26 modelDouble spar box wing constructionPerfectly sized for a 150 – 170cc engineFlush fit factory painted fiberglass cowl, glassed and painted canopy hatch on fuselageStrong yet light weight balsa/plywood constructionCarbon fiber wing and stab tubesPainted pilot and all hardware includedTuned pipe or canister exhaust readyMike McConville signature trim schemeThis model is one of the many available for the Phoenix RC Flight Simulator Product Specifications Wingspan: 122 in (3.1m)Overall Length: 117 in (3.0m)Wing Area: 2770 sq in (179 sq dm)Flying Weight: 38.0 - 42.0 lb (17.2-19.1kg)Engine Size: 150cc - 170cc Gas EngineRadio: 4 channel radio system minimumServos: 9 to 14Trim Scheme Colors: Cream (U878), Orange (U877), Pearl Purple (U847), Silver (U881)Wing Loading: 33 oz/sq ftProp Size: 30-32 inchSpinner Size: 5 inchRecommended Battery: Two (2) 4000mAh receiver batteriesFlaps: NoRetracts: NoControl Throw (Ailerons): Low: 22°, 40% expo; High: 35°, 55% expoControl Throw (Elevator): Low: 12°, 40% expo; High: 45°, 70% expoControl Throw (Rudder): Low: 25°, 40% expo; High: 40°, 45% expoScale: 38%Minimum Age Recommendation: 14 yearsExperience Level: AdvancedRecommended Environment: OutdoorAssembly Time: 20+HoursIs Assembly Required: Yes OverviewHangar 9 is proud to introduce the Sukhoi SU-26MM 3.1m ARF: the first world-class competitive Sukhoi model. The Sukhoi SU-26MM 3.1m is a Pro-Class giant scale aerobatic model designed for IMAC competition and 3D pilots with class-leading performance. This new contest-proven precision and 3D aerobatic aircraft is the latest edition to the Hangar 9 product line. Designed by world-class competition pilot and designer Mike McConville, this Sukhoi SU-26MM 3.1m is constructed from durable, lightweight balsa and plywood and covered with an attention-getting UltraCote® trim scheme in purple, orange, and white. The visual appearance of this Sukhoi is finished off with a high quality, lightweight fiberglass cowling, canopy hatch and wheel pants. The Sukhoi SU-26MM 3.1m has low wing loading and excellent aileron authority enabling the plane to perform fast rolls and extreme 3D maneuvers. This aircraft is perfectly matched for high-powered performance with a 150-170cc engine for excellent vertical performance. The Sukhoi SU-26MM 3.1m comes out of the box with plug-in wings and pre-painted fiberglass cowl and wheel pants allow you to spend less time building and more time flying. Looking for a thrill? Look no further. Gallery Videos 3.1m Sukhoi SU-26MM ARF (WMV) Support Manuals 3.1m Sukhoi SU-26MM Manual (7.6 MB) Warranty1 Authorized Warranty Period (Date of Purchase)What this Warranty Covers Horizon Hobby, Inc., (Horizon) warrants to the original purchaser that the product purchased (the "Product") will be free from defects in materials and workmanship at the date of purchase.2 Authorized Limited Warranty & Limits of Liability InternationalWhat is Not Covered This warranty is not transferable and does not cover (i) cosmetic damage, (ii) damage due to acts of God, accident, misuse, abuse, negligence, commercial use, or due to improper use, installation, operation or maintenance, (iii) modification of or to any part of the Product, (iv) attempted service by anyone other than a Horizon Hobby authorized service center, (v) Product not purchased from an authorized Horizon dealer, or (vi) Product not compliant with applicable technical regulations. OTHER THAN THE EXPRESS WARRANTY ABOVE, HORIZON MAKES NO OTHER WARRANTY OR REPRESENTATION, AND HEREBY DISCLAIMS ANY AND ALL IMPLIED WARRANTIES, INCLUDING, WITHOUT LIMITATION, THE IMPLIED WARRANTIES OF NON-INFRINGEMENT, MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE. THE PURCHASER ACKNOWLEDGES THAT THEY ALONE HAVE DETERMINED THAT THE PRODUCT WILL SUITABLY MEET THE REQUIREMENTS OF THE PURCHASER'S INTENDED USE. Purchaser's Remedy Horizon's sole obligation and purchaser's sole and exclusive remedy shall be that Horizon will, at its option, either (i) service, or (ii) replace, any Product determined by Horizon to be defective. Horizon reserves the right to inspect any and all Product(s) involved in a warranty claim. Service or replacement decisions are at the sole discretion of Horizon. Proof of purchase is required for all warranty claims. SERVICE OR REPLACEMENT AS PROVIDED UNDER THIS WARRANTY IS THE PURCHASER'S SOLE AND EXCLUSIVE REMEDY. Limitation of Liability HORIZON SHALL NOT BE LIABLE FOR SPECIAL, INDIRECT, INCIDENTAL OR CONSEQUENTIAL DAMAGES, LOSS OF PROFITS OR PRODUCTION OR COMMERCIAL LOSS IN ANY WAY, REGARDLESS OF WHETHER SUCH CLAIM IS BASED IN CONTRACT, WARRANTY, TORT, NEGLIGENCE, STRICT LIABILITY OR ANY OTHER THEORY OF LIABILITY, EVEN IF HORIZON HAS BEEN ADVISED OF THE POSSIBILITY OF SUCH DAMAGES. Further, in no event shall the liability of Horizon exceed the individual price of the Product on which liability is asserted. As Horizon has no control over use, setup, final assembly, modification or misuse, no liability shall be assumed nor accepted for any resulting damage or injury. By the act of use, setup or assembly, the user accepts all resulting liability. If you as the purchaser or user are not prepared to accept the liability associated with the use of the Product, purchaser is advised to return the Product immediately in new and unused condition to the place of purchase. Law These terms are governed by Illinois law (without regard to conflict of law principals). This warranty gives you specific legal rights, and you may also have other rights which vary from state to state. Horizon reserves the right to change or modify this warranty at any time without notice. WARRANTY SERVICES Questions, Assistance, and Services Your local hobby store and/or place of purchase cannot provide warranty support or service. Once assembly, setup or use of the Product has been started, you must contact your local distributor or Horizon directly. This will enable Horizon to better answer your questions and service you in the event that you may need any assistance. For questions or assistance, please visit our website at www.horizonhobby.com, submit a Product Support Inquiry, or call 877.504.0233 toll free to speak to a Product Support representative. Inspection or Services If this Product needs to be inspected or serviced and is compliant in the country you live and use the Product in, please use the Horizon Online Service Request submission process found on our website or call Horizon to obtain a Return Merchandise Authorization (RMA) number. Pack the Product securely using a shipping carton. Please note that original boxes may be included, but are not designed to withstand the rigors of shipping without additional protection. Ship via a carrier that provides tracking and insurance for lost or damaged parcels, as Horizon is not responsible for merchandise until it arrives and is accepted at our facility. An Online Service Request is available at http://www.horizonhobby.com/content/_service-center_render-service-center. If you do not have internet access, please contact Horizon Product Support to obtain a RMA number along with instructions for submitting your product for service. When calling Horizon, you will be asked to provide your complete name, street address, email address and phone number where you can be reached during business hours. When sending product into Horizon, please include your RMA number, a list of the included items, and a brief summary of the problem. A copy of your original sales receipt must be included for warranty consideration. Be sure your name, address, and RMA number are clearly written on the outside of the shipping carton. NOTICE: Do not ship LiPo batteries to Horizon. If you have any issue with a LiPo battery, please contact the appropriate Horizon Product Support office. Warranty Requirements For Warranty consideration, you must include your original sales receipt verifying the proof-of-purchase date. Provided warranty conditions have been met, your Product will be serviced or replaced free of charge. Service or replacement decisions are at the sole discretion of Horizon. Non-Warranty Service Should your service not be covered by warranty, service will be completed and payment will be required without notification or estimate of the expense unless the expense exceeds 50% of the retail purchase cost. By submitting the item for service you are agreeing to payment of the service without notification. Service estimates are available upon request. You must include this request with your item submitted for service. Non-warranty service estimates will be billed a minimum of ½ hour of labor. In addition you will be billed for return freight. Horizon accepts money orders and cashier's checks, as well as Visa, MasterCard, American Express, and Discover cards. By submitting any item to Horizon for service, you are agreeing to Horizon's Terms and Conditions found on our website http://www.horizonhobby.com/content/_service-center_render-service-center. ATTENTION: Horizon service is limited to Product compliant in the country of use and ownership. If received, a non-compliant Product will not be serviced. Further, the sender will be responsible for arranging return shipment of the un-serviced Product, through a carrier of the sender's choice and at the sender's expense. Horizon will hold non-compliant Product for a period of 60 days from notification, after which it will be discarded. United States: Electronics and engines requiring inspection or repair should be shipped to the following address: Horizon Service Center 4105 Fieldstone Road Champaign, Illinois 61822 All other Products requiring warranty inspection or repair should be shipped to the following address: Horizon Product Support 4105 Fieldstone Road Champaign, Illinois 61822 Please call 877-504-0233 or e-mail us at firstname.lastname@example.com with any questions or concerns regarding this product or warranty. United Kingdom: Electronics and engines requiring inspection or repair should be shipped to the following address: Horizon Hobby Limited Units 1-4 Ployters Rd Staple Tye Harlow, Essex CM18 7NS United Kingdom Please call +44 (0) 1279 641 097 or e-mail us at email@example.com with any questions or concerns regarding this product or warranty. Germany: Electronics and engines requiring inspection or repair should be shipped to the following address: Horizon Technischer Service Christian-Junge-Strasse 125337 Elmshorn Germany Please call +(0) 49 4121 2655 100 or e-mail us at email@example.com with any questions or concerns regarding this product or warranty. France:Electronics and engines requiring inspection or repair should be shipped to the following address: Horizon Hobby SAS 11 Rue Georges Charpak 77127 LIEUSAINT Please call +33 (0) 1 60 18 34 90 or e-mail us at email@example.com with any questions or concerns regarding this product or warranty. China: Electronics and engines requiring inspection or repair should be shipped to the following address: Horizon Hobby – China Room 506, No. 97 Changshou Rd. Shanghai, China 200060 Please call +86 (021) 5180 9868 or email us at firstname.lastname@example.com with any questions or concerns regarding this product or warranty. Modified: 11/13/2012 Related Parts Completion Guides Recommended Electronics and Accessories See All Evolution 3 Wire Ignition/RX SwitchEVOA112 11X 2.4 A/S/H with R921X RX NO SXJRP1100X Servo Extension 12-inch Heavy-Duty, GoldJRPA098 Servo Extension 18-inch Heavy-Duty, GoldJRPA099 Parts Listing See All Fuselage with Hatch, 3.1m Sukhoi MM ARFHAN106001 Hatch with Canopy, 3.1m Sukhoi MM ARFHAN106002 Left Wing Panel, 3.1m Sukhoi MM ARFHAN106003 UltraCote, SilverHANU881 Optional Accessories See All Spektrum Alpha-6 Stability SystemSPMAS1000 Extreme Big Tote Double 59"x35"x22" Red/BlackWGT211

subset: commoncrawl


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The Imperial Stormtroopers are fictional soldiers from George Lucas' Star Wars universe. Stormtroopers are elite soldiers, working as the marines for the Imperial Navy, under the leadership of the evil Sith Lord and Emperor Palpatine and his commanders, most notably Darth Vader and Grand Moff Tarkin.
They are shown in collective groups of varying organizational sizes ranging from squads to legions, and, for some, their armor and training is modified for special operations and environments.
In Star Wars Episode II: Attack of the Clones, the first troopers were cloned from bounty hunter Jango Fett, to be the Army of the Republic in theClone Wars. In Star Wars Episode III: Revenge of the Sith, the Clone troopers execute Order 66 at the command of Chancellor Palpatine, attacking their Jedi generals.
Initially, the stormtroopers serve as the army of the Galactic Empire, putting down revolts and establishing Imperial authority. The Stormtrooper Corps swell in size after Palpatine allows the addition of recruits and conscripts alongside the clones.
When the Empire is firmly stabilized and an Imperial Army/Imperial Navy established, the stormtroopers become Palpatine's personal army and are stationed on Imperial bases and cruisers, as well as on the Death Star. They maintain these roles until the Empire's collapse after Palpatine's death in Star Wars Episode VI: Return of the Jedi.
The troopers' most distinctive equipment is their white battle armor, inherited from their time as clone troopers. The complete armor set completely encases the body and typically has no individually distinguishing marking (in contrast to the clone trooper armor, which typically had various colorings to denote rank or unit, stormtrooper armor has no rank affiliation).
Stromtroopers Dressed Like Popular Superheroes
May 6, 2012 by


text:
Telling a "pompous know-it- all" private investigator in his 15th year of dedicated practice (this would be me) that he was required to extract a confession of guilt from a guilty subject was nothing short of a challenge on the level of a double-dog dare.
A hospital's Administrative Director called, introducing me to his Director of Security (we will call 'John'). They were both befuddled when cash shortages began to appear through missing funds from the parking lot's coin-operated vehicle gate and suspected internal fraud.
John was quick to share some of his personal reservations regarding the honesty and integrity of a few of his newly hired security personnel. He supported his suspicion, citing the collection process that only required security to empty the money box of daily take and to transport the funds to accounting.
Fact-finding eliminated the possibility of forced entry, the duplication of keys, ex-employees with keys or faulty equipment, leaving suspicion to rest squarely on either security personnel or the accounting department.
Interview Revelations
Guards were first interviewed, who revealed that the daily deposit did not go directly to accounting, as policy suggested, but that the bag of coins was brought to the security office to be counted before it was brought to accounting.
And, you may ask: "Who might have authored that policy change?" John, the Director of Security did. And why? "Just because he wanted it that way."
Further questions posed to cafeteria and gift shop staff revealed that John always paid for everything he bought with what seemed to be an endless supply of coins.
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Download TemplateWhat followed should have been a seamless interview that lead to an interrogation, a confession and concluded with the laying of criminal charges.
The Bungled Interview
John arrived at my office under the pretext of discussing my findings and to discuss other investigative options.
Producing my audio recorder and, at the same time, asking whether he minded that I record the conversation caused an odd reaction for a man who was still under the illusion of helping to further an investigation. John moved his chair back from the recorder and reared back on the chair's legs to put distance between himself and the obvious threat. That single act in any interview could be an indicator of fear and of guilt on some level.
I opened with a flood of irrefutable findings, including statements from security guards, cafeteria employees and gift shop workers, while he nodded in agreement to the onslaught of evidence being presented against him. The coup de grâce occurred when I produced a series of photographs taken by his own security supervisor who had taken photos daily showing a depletion of cash from the bag of money being held in John's own desk drawer.
Dogged Denial
When it was over, John quietly leaned forward staring at the floor with rounded shoulders and clearly defeated. What was a normal speaking voice moments prior now dropped to barely a whisper in order to avoid being heard on tape. John denied. Yes, he denied everything.
No argument I could make, nor anything I said or did, would convince him to admit to the thefts. John left my office in tears, without admission, professing ill treatment, threatening legal action and promptly submitted his resignation to the hospital citing indignation and hurt feelings.
There were so many lessons learned from this interrogative failure but the most important was my clear lack of training and expertise. All the signs were there, but I failed to secure the admission of guilt. Subsequent training and courses have rendered the mistakes of that incident painfully obvious.


text: We pride ourselves on our 5 star reviews and want to serve you the best way possible. Please read or leave us a review on our Google Business Page or Facebook Page. Heart Healthy Heart Disease, High Blood Pressure, High Cholesterol, and Diabetes are all unfortunate effects from many of our non-active, stressful, horrible diet lives!It's take to concentrate on your heart and your health… because unlike so many of our body parts and organs, when your heart goes… it's game over!This is where HealthSource becomes so much more than your "Chiropractor". We are total wellness specialists, and the truth is, the majority of what we do from exercise to nutrition and weight control is for one main reason…. To keep you with a Healthy Heart! It's the ultimate thermometer of your health status!Take a few minutes and explore the related topics below and then contact your HealthSource Chiropractor for an appointment to talk about YOUR lifestyle choices and where you can make the biggest change in your life…ever! Click here for your Heart Disease coupon! Related Topics: Diabetes Exercise Cholesterol Heart Disease High Blood Pressure Nutrition Weight Control Call (803) 572-4180 or click to schedule your HealthSource of Columbia appointment today!


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Richard Thompson
Montclair, N.J.
The backyard clothes line clothespin
Health, hygene & education.
dan k
see below:
1.Brooklyn bridge
2.Yellow taxi
4.Steam pipe exhaust tube on the street
5.Subway car
6.Flatiron bldg.
7.Wall st bull
8.Grand central clock (or ceiling)
9.The oyster (tied to the origins of our wealth)
10.the Cyclone (don't underestimate the importance and influence Coney Island had on our country)
richard burten
Oradell, New Jersey
The Flushing Remonstrance
This is the foundation of both New York's and the US Constitution
andrew bain
A slave shackle.
Without it the story would be incomplete.
There is this illusion that slavery was
only a southern phenomena, whereas
unpaid labor built New York from day one.
East Side/NYC
The oyster!
It was the food of the native Indians, and later both the poor and the rich harvested from our rivers in abundance. We're still finding the shells when we excavate. We're literally built on the oyster.
Any "Ray's Original Pizza" sign
It shows the "I'm first/I'm best" spirit of New York--exasperating, humorous, infectious
The window catwalks in grand central terminal
Just one of the many spectacular features of GCT. The zodiac ceiling and the whispering hall are also special.
Dan Higgins
A Spaldeen (others have done this already)
By the way - if you called it a "Spalding", you didn't live in the part of the Bronx I did! (Wakefield)
Every child in NYC played with one (before video games)
You will find them EVERYWHERE in the city - on rooftops, in sewers, on El tracks, on fire escapes.
Off the point / Stickball / Punchball / Boxball / Hit the stick all required a Spaldeen.
You would stand in the 5&10 holding one ball in each hand head-high. Drop them both, then take the higher-bouncer. Then take another out of the box, and repeat until you had the highest bouncer in the box.
And you had a straightened coat hanger with a loop on the end to fish them out of the storm drains.
Joby Jacob
Hollis Hills, NY
The Flushing Remonstrance
The Flushing Remonstrance was the letter the people of Flushing sent to Governor Stuyvesent asking that he leave the Quakers alone. As far as they were concerned if the Quakers didn't bother anyone they could not in good conscience persecute them. It influenced the First Amendment and presages the unique New York attitude about religion.
Upper West
The yellow taxi...
...from the checker to the hybrid. They're every where (and many natives never learn how to drive!). You know the movie scene is a New York street if the majority of the cars are yellow.
Matthew Yanchuk
NYC subway map
It is read by millions from New Yorkers to visitors and you get o know the lay out of the city in one page.
Elizabeth S. Titus
Upper West Side/CPW
NPR podcast of show about Walt Whitman, his life in NYC at a pivotal time in history, his most famous poem, Song of Myself
Song of Myself
by Walt Whitman
Walt Whitman, a kosmos, of Manhattan the son,
Turbulent, fleshy, sensual, eating, drinking and breeding,
No sentimentalist, no stander above men and women or apart from them,
No more modest than immodest.
Elizabeth S. Titus
upper West Side/CPW
Vintage postcard of Chelsea Piers showing Lusitania
Transatlantic travel began in NYC, and the Lusitania sailed from Chelsea Piers on the doomed voyage that led the US into WW1.
Rich Koch
Any manhole cover
Why? Because it was the infrastructure of New York - the sewers, the piped in water, and later gas, electricity and communications - that allowed New York to expand north from the Battery, to become the battery the country's explosive growth. And it was the ability to put it all under our feet that allowed our city to become an architectural and by extension cultural powerhouse.
Elizabeth S. Titus
upper West Side/CPW
Section of plank and rail from the High Line
The best of the best of NYC! Who doesn't love the High Line? It has layers of the city's history, plus, it shows what anyone with the gumption can do to make things happen in the city!
"The High Line was built in the 1930s, as part of a massive public-private infrastructure project called the West Side Improvement. It lifted freight traffic 30 feet in the air, removing dangerous trains from the streets of Manhattan's largest industrial district. No trains have run on the High Line since 1980. Friends of the High Line, a community-based non-profit group, formed in 1999 when the historic structure was under threat of demolition."
Elizabeth S. Titus
Upper West Side/CPW
The Unisphere
The Unisphere sits in Flushing Meadows-Corona Park in Queens. It is a famous sight and is visible to drivers on the LIE, the Grand Central, and Van Wyck, as well as to airline passengers arriving and departing from LaGuardia and JFK.
Laura Benin
The Pigeon
During my childhood in NYC, pigeons greeted me every day as I walked home from school. Their very abundance on the streets made me think that they were a special city bird. Of course, my mother advised me to stay away from them because they were "dirty," thus making me fearful of all birds and all animals in general.
Tarrytown, New York
The object I am nominating is an edition of Washington Irving's Diedrick Knickerbocker's History of New-York (1809).
This book was Irving's first great literary success, launching the author's career as the noted American author of his day. In addition, thanks to this book, "Knickerbocker" has become synonymous with New Yorker. Beer, short pants, even bread shared this name over the years. Today it lives in the name of our basketball team, the New York Knicks!
New Jersey
Steel Cable
Invisible to many and found in every building with an elevator... in every major bridge.
Without it the city couldn't move... or have been built to such size... or extend its influence into its environs.
Almost every city resident or worker uses it daily without touching it!
Allendale, NJ
The "M" Metropolitan tab
What would NYC be without it's museums.


text: Home » News » BIWIN More Than Just Flash Products BIWIN More Than Just Flash Products MIG-31 April 29, 2013 News Assignment Writing Service In Sri Lanka BIWIN, the world-leading expert in the development and manufacture of NAND flash memory, announced the start of the sales for its commercial and industrial grade SSD product lines in Russia, Japan, Germany, and the U.S.A. BIWIN has accumulated a large amount of expertise in the past 18 years in the NAND Flash industry and they are one of the biggest NAND Flash related products manufacturers in China. How To Write Short Essays In the highly competitive world of flash memory production, quality and flexibility are two areas that BIWIN has shown a compelling track record within the industrial and commercial flash market. But the key feature of their product is not just the great specs on offer but the wide variety of customization that customers can take advantage of. 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BIWIN allows customers to choose and match an industrial grade flash module based on different controllers, flash chips, operating temperature ranges and interfaces. http://www.smn.gob.hn/?speech-therapy-masters-thesis Speech Therapy Masters Thesis On the controller front, BIWIN offers more than 20 different models of controllers and can even bring in new controllers as per a customer's request. BIWIN has established a strategic relationship with Taiwan controller company SMI and Jmicron. BIWIN is LSI's golden firmware members. This allows them the advantage to get direct, first hand tech support. As for flash chips, they can not only source original SLC and MLC flash chips from TOSHIBA and Micron, but also package their wafers into flash chips in-house. For temperature range options, they use industrial grade controllers and test and source out the highest quality flash chips. SSDs can be made to cover three grades of operating temperatures: (0 to 70 ℃), (-20 to 70℃), or (-40 to 85℃). To insure the quality, they do testing using state-of-the-art facilities and specialized equipment. Because of their facilities, the quality control at BIWIN allows the testing for every piece of product with multiple checks including the world leading testing device, the FLEXTAR F-500B. BIWIN can offer flexible MOQ (minimum order quantity), flexible product solutions. As for the service offered to industrial customers, BIWIN stands out among the competition. They provide flexible MOQ and a flexible cooperation mode for distribution or for your own brand. Their sales and marketing is ready to listen and is open to new ideas. By providing a wide range of choices of commercial and industrial grade SSDs or by designing the kind the customers need, BIWIN is not only providing products and services, but they are also offering greater possibilities. 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text:
Dortmund is chasing a third Bundesliga title. The season following a surprise title win is supposed to be the hardest. Dortmund proved that theory is nothing more than a theory when they won with ease last season. This season, however, teams are seemingly finally learning how to deal with them.
Of-course, Marco Reus is currently still only settling in, trying to cover the gaps left by Shinji Kagawa. Mario Götze is not fully fit as of yet and is only coming into matches from the bench. Nürnberg defended doggedly and launched well-worked counters. They could have snatched a winner in the match as well.
Tomas Peckhart was able to score due to sloppy defending to a certain extent. The draw was perhaps the correct reflection of the match. Last week, against Bremen, Dortmund gave away a lead but thanks to Götze, snatched a win away. We will learn more about Dortmund's mettle as the season wears on.
A 4-0 loss to a side that is three divisions below them in the Pokal followed up by an opening day loss to Mönchengladbach had fans of Hoffenheim complaining. Thus, Markus Babbel decided to set up a meeting between the fans and club officials. Plenty of beer followed; Hoffenheim, seemingly filled with indolent players, crashed to a 4-0 defeat to a newly promoted side, Frankfurt.
Frankfurt and Armin Veh deserve credit for their two victories. However, Hoffenheim was simply too awful. They were opened up far too easily; Babbel hardly had an explanation for the tumultuous events on the pitch. And of-course, they not only gave up four goals but also had two players sent off.
There is a certain amount of discontent in the club to say the least. Babbel, whose coaching track record isn't too bad but isn't fantastic either, seems, strangely, out of his depth. Hoffenheim has to find quick solutions. They are filled with good players who, if involved properly in matches, can see Hoffenheim through to a European spot. Babbel needs to turn things around to not only save the club but also to save his job.
Who will be involved in the relegation battle at the end of the season? Most picks contained the names Fürth and Düsseldorf. Fürth picked up a first victory of the season against Mainz while Fortuna drew against Gladbach. Hamburg lost in the derby to Bremen but has secured the services of a former star who might be able to save them, Rafael van der Vaart.
Frankfurt was another pick; they currently sit second and are the only side apart from Bayern to have picked up a full complement of points after two match-days. Augsburg has started with two losses but played well enough against Schalke to show they have the game-plan but they just aren't taking their chances.
Nürnberg meanwhile has started with a very decent away win and a home draw. Hoffenheim is in big trouble; nobody called them a relegation candidate prior to the season. For now, matters remain as unclear as ever.
Ever since Mirko Slomka took over, things have drastically changed. From relegation candidates, Slomka has turned them into a side that can challenge for European spots every season. Hannover 96 made a run for the third spot in the league in 2011. They opened this campaign with a 2-2 draw against Schalke in which they had to come from behind.
They thrashed Wolfsburg 0-4 in the previous match-day. Szabolcs Huszti set up four goals while Artur Sobiech grabbed two. Schalke is the only challenger to the duopoly of Bayern and Dortmund. Hannover is seemingly a dark horse for the title. They are more consistent than Bremen and Leverkusen as well and could grab that fourth Champions League spot this season and more.
Javier Martinez has featured in fourteen minutes of Bayern's season so far. He hasn't scored a goal- nor has he assisted any. However, he has already had a major impact if Sunday's performance is anything to go by. Almost each and every Bayern player knows that he is not going to be granted a spot on the first eleven (except Philipp Lahm and Manuel Neuer of-course).
The competition for places seems to have awoken the beasts that Bayern are capable of being. Stuttgart's lead via Martin Harnik lasted about six minutes. The Bayern midfielders and strikers sprung into action and struck six times in the span of twenty minutes. Bruno Labbadia's men made Bayern's job easier for them. Martinez's capabilities are unknown to the Bayern fans as of yet. His impact on the field will be seen after the international break.
Australia | Mar 28 5:00am | United Arab… |
Iran | Mar 28 8:00am | China |
Germany U21 | Mar 28 11:00am | Portugal U21 |
Netherlands | Mar 28 2:45pm | Italy |
Ireland Rep… | Mar 28 2:45pm | Iceland |
Portugal | Mar 28 2:45pm | Sweden |
France | Mar 28 3:00pm | Spain |
Bolivia | Mar 28 4:00pm | Argentina |
Ecuador | Mar 28 5:00pm | Colombia |
Honduras | Mar 28 5:00pm | Costa Rica |


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Poll: Floridians Not Down With Paul Ryan's Medicare Plan
Nice guns, bro |
See also:
Paul Ryan Talks Medicare, Uses Mom As Mascot to Make His Point
He trotted out his mom like Sebastian the Ibis last week in front of thousands of retirees to tell them his Medicare plan is going to be a good thing, and that President Obama's plan will turn you over to a panel of bureaucrats who will then determine whether or not a person deserves to live.
But the Power of Momma Ryan -- as spry and excitable as she can be -- doesn't seem to be making a dent with Floridians, according to a new poll.
While RoboRomney's decision to go with Ryan as his Boy Wonder might have given him a micro-bump to cut Obama's lead in swing states in the latest Quinnipiac University/CBS News/New York Times poll, the same Floridians polled say they like Medicare just the way it is, and don't want it to turn into a voucher program, as Ryan's plan proposes.
"By more than four-to-one margins, voters in each state say the health-care program for the elderly is worth the cost, and six in ten say they favor keeping the current Medicare model," said pollster Peter Brown.
Upcoming Events
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The poll says that only 11 percent of Floridians support big reductions in Medicare to reduce the federal deficit. Meanwhile, 48 percent support minor reductions while 35 percent favor no reductions at all.
Ryan says major cuts are needed, while Obama intends to only give it a few tweaks.
According to the Congressional Budget Office, Ryan's proposal would raise seniors' out-of-pocket expenses by $6,500 per year, while Obama's plan would extend Medicare's solvency for another eight years.
Ryan insists that he and Romney will win this debate. But, so far, the numbers ain't helping.
But what are numbers and facts when you can just scare people and use Heavy Metal songs to get people all fired up?
Well, when in doubt, there's always Momma Ryan.
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1. I just got an exchange evo this morning and the hardware version is three. does any one know if this is the latest? 2. i had a widget to toggle me mobile network on the phone i just exchanged. i can't find out how get it back. i tried going to widgets-settings-ect but it wasn't there . i don't remember if i got it from the market or what. Thank you guys so much for your help!
1. I have heard talk of a version 005 out there but no photo proof has been presented 2. So you Long Pressed then chose Widget then Settings and Mobile Network isn't there? Double check because it is there. You have a 4g, Airplane Mode, Bluetooth, GPS, Hotspot, Mobile Network, and Wi-Fi widgets are all there
The hardware 0005 guy was just trollin, http://androidforums.com/htc-evo-4g/113755-new-replacement-phone-wtf-yea-buddy.html
003 but don't get hung up on hardware versions.... No one knows what they mean really and yes there are some differences cosmetically and two different screens manufacturers but the software and firmware are the same
0003 is the latest. The only major difference that people are noting is that 0003 could have Epson screens (some Novatec), while 00002 has only Novatec. Wouldn't worry about it.


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This wonderful terraced lot offers short distance views and convenience to Wimberley. Great location! Bring your builder and build your dream home. Well and septic needed.
Electricity Available, Above Ground
Date | Details | Price | Change |
Price Reduced (from $96,960) | $89,000 | $7,960 (8.21%) |
Property Listed by: Century 21 Randall Morris
The information being provided is for consumers' personal, non-commercial use and may not be used for any purpose other than to identify prospective properties consumers may be interested in purchasing.
Based on information from the Austin Board of REALTORS® (alternatively, from ACTRIS) from March 25th, 2017 at 2:30am CDT. Neither the Board nor ACTRIS guarantees or is in any way responsible for its accuracy. The Austin Board of REALTORS®, ACTRIS and their affiliates provide the MLS and all content therein "AS IS" and without any warranty, express or implied. Data maintained by the Board or ACTRIS may not reflect all real estate activity in the market.
All information provided is deemed reliable but is not guaranteed and should be independently verified.


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Product #: AL-320/55
# of items:Total:
Eagle Pesticide Safety Cabinet - 30 Gallon - PEST32 001-PEST32
Eagle UI-50-S - Safety Can - 5 Gallon 001-UI-50-S
Eagle Metal Base Poly Tube Butt Can - Beige - 2 ½ Gallon Capacity 001-1202-BEI
Product Description:
Technical Information: Spec. Sheet | M.S.D.S. | Label
PLEASE NOTE: Some Herbicides and Insecticides are not available for sale in states where prohibited by law and/or regulation. Barren NOT AVAILABLE in AK, CA, CO, CT, DE, HI, IL, IN, ME, MD, MA, MI, NH, NJ, NM, OH, PA, RI, TX, UT, VT, VA, WA, Canada & Puerto Rico. BARREN weed killer is a powerful ready-to-use liquid non-selective herbicide for use where control of all vegetation is desired. It is also a soil sterilant offering total kill with long lasting residual action that works to stop vegetation from coming back for up to 1 growing season. It is also only recommended for non-cropland areas away from residential/recreational areas, outside of the drip line of trees and away from the roots of desired plants, brush and trees. Contains 1.09% 2,4-D, .098% Bromacil
Please note: For items that ship by common carrier, you will be contacted by phone or email to confirm shipping charges prior to processing your order.
Product Name: Barren - Weed Killer - Non-Selective Herbicide - 55 Gallon Drum
Price (ea.): Call for price


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Ella Kross – Urethral Cruel Sounds Play!
Today I`m going to punish this slave`s cock and balls in my back yard, andI get to work by sitting atop his nude body and binding his genitalstightly with rope. With a new set of solid steel urethral sounds I shove a metal rod deep into into his pee hole while he groansin discomfort, and hearing how miserable he is makes me laugh. I love knowing he`s in pain, so much so that I swap out the metal rod for an evenlarger one and use it to probe his urethra. How much of this thick metal shaft can I work into his tight pee hole? I`m about to find out, and as hewrithes in pain beneath me I shove the rod inside of him while smiling ear to ear. His pain is my pleasure! I just wants to stick them as far down as they will go!
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Thursday, July 21, 2011
Storing Fresh Fish
Fish are not meat. Remember that and you will be on the right path toward taking good care of the fresh fish you bring home. And take care you must, because fish are both expensive and are among the most perishable foods we eat.
Doing it right is not difficult, but it is best done with a little extra equipment.
First, you need a large plastic container. Ideally you also will have a slightly smaller container that fits entirely inside the larger one. If you take this step, drill or punch many holes in the bottom of it. This smaller container will hold your ice and your fish. If the smaller container will touch the bottom of the larger one, you will need something to keep it elevated.
What's the point of all this? You will need to keep your fish on ice -- even in the refrigerator. And ideally, you will keep them with their back fins facing up, as if they were still swimming. The reason for this is because unlike meat, fish will rot quickly, even in the fridge, unless iced.
Why would this be? Because fish generally swim in water that is colder than air, sometimes a lot colder.
This is why fish fat is so good for you. Because it is liquid even at very low temperatures, it does not gunk up your system the way a highly saturated, dense fat such as beef suet does. Fish fat is also loaded with omega-3 fatty acids, something most other meats -- with the exception of grass-fed animals -- lack.
So here's what you do when you bring your fish home. Make sure the smaller container is up off the larger one, then fill the smaller container with crushed ice. It must be crushed ice. Large ice cubes will take too long to melt and can discolor the skin of the fish.
Put the fish in, bellies down, backs up, cover the container and you're done.
How long can you keep a fish this way? It depends. If you caught the fish yourself, you will get as much as a week to 10 days. A market-bought fish won't last that long, nor will a piece of fish such as a fillet or a steak. Those will remain at peak condition only a few days.
Replace the ice as it melts, and pour off the melt water.
One more thing: If the fish is lean, such as Tilapia or Gourami or Kelah, you get an extra day. If it is oily such as Catfish, take a day off the total time. And of it is a really oily fish such as a Patin, eat it now -- it won't get any better tomorrow...
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Sunday, October 9, 2011
Today in motorcycle rallies on the Bowery
Photos by Bobby Williams. Party was at Bowery Electric. BoweryBoogie has more on the annual Hells Angels Biker Bash here.
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EV Grieve is an East Village blog where you'll find local news on the real estate, restaurants and residents of the East Village NYC.


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Article: |
Piracy is Progressive Taxation, and Other Thoughts on the Evolution of Online Distribution | |
Subject: | Well stated | |
Date: | 2002-12-12 05:39:36 | |
From: | ellyssian | |
Hopefully, the people who need to read that will (RIAA and so forth). As a musician, poet, and author I see the web as an opportunity. A few select people think it will take a few pennies from their pocket, and they complain loudly and pump out misinformation to slant the laws in their favor at the expense of everyone else. |


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Lot 244: Very Large Famille Rose Bowl
Important Asian & European Auction
by Arts Of World Auctioneer and Valuer
October 23, 2016
Alexandria, Australia
Live AuctionSold
Looking for the realized and estimated price?
Description: 19th century. Presented with a red dragon and phoenix. Guang Xu mark on the base, of the period.


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Newspaper Source™ Plus includes more than 1,000 full-text newspapers, providing more than 38 million full-text articles. The database contains comprehensive full text for major newspapers such as the Christian Science Monitor, San Francisco Chronicle, The Sydney Morning Herald (Australia), The Times (UK), Toronto Star, USA Today, The Washington Post, The Washington Times (DC) and others. All staff articles are also included from many newspapers, including The Philadelphia Inquirer, Houston Chronicle, Star Tribune (Minneapolis), etc.
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I believe in the Church of Baseball. I tried all the major religions and most of the minor ones. I've worshipped Buddha, Allah, Brahma, Vishnu, Siva, trees, mushrooms and Isadora Duncan. I know things. For instance, there are 108 beads in a Catholic rosary and there are 108 stitches in a baseball. When I learned that, I gave Jesus a chance
Ron Shelton


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Three Little Lion cubs
Belgian Lion taken over by granddaughters
Barbarella Fokos 11 a.m., March 27
This evening (July 30), the board of watchdog Utility Consumers' Action Network (UCAN) agreed to hire an accountant to prepare the books for the period July 1, 2011 through June 30 of this year. Kim Malcolm, the executive director hired this year, said UCAN has $2 million, almost all of which is in the bank. However, she stressed, UCAN has "very limited resources" and a "limited group of staff." The subject did not come up in open session, but it is a matter of record that the board and previous management under Michael Shames and Bob Ames chalked up huge legal bills after the organization filed for dissolution earlier this year. Charles Langley, who handles marketing for UCAN, said that rent has been reduced by 57% and web administration costs by 50%.
UCAN is pushing forward monitoring the general rate case filing of San Diego Gas & Electric (SDGE), safety issues at the San Onofre nuclear plant that is part owned by SDGE, fraud and privacy issues, and the like. UCAN will take up SDGE's policy of charging a customer for debts of a former roommate or housemate who has moved out.
The board had a 47 minute closed session before the open meeting, then went back into a secret meeting afterwards. Malcolm said "pending litigation" would be at least one subject discussed in private.


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MYNT 1792 - Marie Faux Leather T-Shirt
MYNT 1792 - Marie Faux Leather T-Shirt
Out of stock
The Marie Faux Leather T-Shirt is the perfect piece to add some edge into your wardrobe. With a faux leather front and ponte back, this mixed media style is on point for the season. This dressy T-shirt can be paired with skinny jeans or a skirt for an edgy-meets feminine look.
Model is wearing a size 1X.
Shell 1 Fabric: 60% Viscose, 35% Nylon, 5% Elastane, Shell 2 Fabric: 50% Polyester, 50% Faux Leather (PU)
Care: Machine wash cold inside out, delicate cycle. Mesh laundry bag for delicates recommended. Do not bleach. Hang to dry.


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1 July 2010
Sports, health stats and comic relief
marianne waller
EDO event explored new possibilities for publishers and editorial designers
Last night was the EDO's iPad app night at London's St Bride Library, writes Marianne Waller.
25 June 2010
On target
the events department
Looking forward to a Roman Cieślewicz retrospective at the RCA
'Roman Cieślewicz', at London's Royal College of Art from 16 July–7 August, features more than 150 items by the Polish poster legend. Vertigo (top) dates from 1963, the year Cieślewicz (1930-96) moved to Paris.
23 June 2010
'We want fresh bread.'
john l. walters, the awards department
Prizes for Yasuda, Schraivogel, Windlin, etc. at Brno Biennial 2010
Earlier this week I experienced the pleasures and pains of sitting on the international jury of the Brno Biennial 2010, writes John L. Walters. The fun came from looking at lots of interesting international work (nothing from the UK) in the pleasant company of fellow jurors Alan Záruba, Igor Stanisljevic, Koichi Sato, Scott Santoro, Lizá Ramalho of R2, Karel Martens and Petr Babák.
13 June 2010
Stop, look, listen
john ridpath, the events department
A preview of Black Dog's latest exhibition: 'Modern British Posters'
A new exhibition showcasing the best of British poster design opens at Black Dog Space tomorrow. The show coincides with the launch of Paul Rennie's Modern British Posters: Art, Design & Communication (Black Dog Publishing).
10 June 2010
Civil rights in New York
frederico duarte, the events department
Two current exhibitions with images that 'steered a drive for freedom'
I learned about two exhibitions on the civil rights movement currently showing in New York through Holland Cotter's review in the New York Times, writes Frederico Duarte.
9 June 2010
The friendly side of graphic art
Outline asks illustrators and designers to share their views of London
Currently occupying a pop-up gallery in the UK capital until early July, Outline Editions presents '001 London: 'the big city through the eyes of Britain's leading graphic artists'.
19 May 2010
Graphics and the uncanny
john ridpath, the events department
Rick Poynor revisits the surreal for a show at the Brno Biennial 2010
'Let us not mince words: the marvellous is always beautiful, anything marvellous is beautiful, in fact only the marvellous is beautiful' (André Breton, Surrealist Manifesto). At this year's Brno Biennial, Rick Poynor will be guest curating an exhibition of beautiful, marvellous artwork entitled 'The Uncanny: Surrealism and Graphic Design'.
5 May 2010
Diagrams of delight
An exhibition by Seoul's Zero Per Zero at Kemistry Gallery
Zero Per Zero's first UK exhibition opened last week at Kemistry Gallery in Shoreditch, writes Sara Martin. The highlights are their re-interpreted transport maps for cities such as Tokyo, New York and their home town of Seoul, South Korea.
27 April 2010
Schweizer Reize
Swiss travel books and posters at the National Library in Bern
An exhibition of historic Swiss travel books and posters at the Swiss National Library in Bern reminds viewers that tourism in the region is 'old as the hills' – and so is the printed matter that it generates, writes Jane Cheng.
23 April 2010
West End girls and boys
'Pick Me Up' puts graphic art and illustration on the London gallery map
'The west shall shake the east awake … while ye have the night for morn …' Marshall McLuhan was fond of quoting this poetic nugget from James Joyce's puntastic Finnegans Wake.


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There's something urban, international and comfortably familiar about this well-loved hotel restaurant, particularly when host Mickey Bakst makes his... Read More
Snuggled into a tiny, rustic house hidden down a side alley, chef Jill Mathias keeps diners salivating for her daily menu that gives a nod to Southern... Read More
Oops, we stayed more than two hours for lunch (again), ordered three courses, and drank coppery-colored rosé. I just don't want to leave this one-room... Read More
Please, please meet me here, anytime. Owners Fanny (a French beauty) and Patrick Panella (tall and handsome) already had the city's favorite wine bar,... Read More
In a line-up of beach bars, condos, and ice cream shops on the front beach of Isle of Palms, Coda del Pesce is an outlier, serving octopus, snapper,... Read More
Sister restaurant to Charleston mainstays Magnolias and Blossom, Cypress serves a seasonal, Lowcountry- and Pacific Rim-inspired menu by James Beard... Read More
This place is a classic for fried seafood, turkey wings, and a can of soda while you're waiting…and you'll probably have to wait a bit. At this longtime... Read More
The bartender recommends the fresh charcuterie (they also have a cured option), and we think the catfish rillettes are smoky-incredible. Another sure... Read More
Two words: pizza and fire. This restaurant features in-season ingredients, and makes great dough, pies, and salads, all while cooking and baking with a... Read More
The founding pitmaster at Fiery Ron's is a chef with big restaurant experience, and he's featured live music since day one. Friends with kids love this... Read More
The kitchen consistently churns out marvels such as duck egg tartine, mangalitsa prosciutto with sage and persimmon, fluffy ricotta gnocchi, and locally... Read More
Though it's best known for its seasonal, locally sourced cuisine, the wine program of this beloved downtown restaurant has also won serious... Read More
Tradd Newton renovated an abandoned, 1940's naval building to open Fleet Landing. The restaurant sits on top of the marsh on the city's peninsula... Read More
I love to order the Lowcountry gumbo at Fleet and sit on the outside deck. Right downtown and literally on pilings above the water and marsh grass, it's... Read More
Another clandestine location, you'll get to the entrance along a narrow, one-block street. Then enter a cozy room with a small, well-worn bar, the clink... Read More
Open since 1984 on Broad Street, this is not a coffee shop per se, but it's a well-known fact that G&M helped bring French press coffee to... Read More
Several times, I have been lucky enough to be at the table when one of Chef Frank McMahon's icy towers of seafood arrives. It feels like everyone in the... Read More
Get this—a fried egg, pimento cheese, grilled okra, fresh tomato, pineapple, Sriacha mayo, Canadian bacon—the toppings for BBQ sandwiches and tacos here... Read More
Hemingway vibe. High Cotton, which serves roughly 800 Espresso Martinis a month, takes its name from an old southern term for living well; high-growing... Read More
Chef Robert Stehling may not be a Lowcountry local, but his "highrise" biscuits and breakfast shrimp are as authentic as Nana used to make, and the... Read More
This breakfast-lunch-and-dinner menu is built on many of the signature Charleston flavors I love most—like butter beans, collard greens, fish and grits,... Read More


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15W, 2-channel Guitar Combo Amp with One 8" Speaker, 3-band EQ Control, Line In, and Line/Headphone out with Speaker Emulation
A Compact 15-watt Combo with Marshall Tone to Spare!
The Marshall MG15 guitar combo amplifier gives you that great Marshall tone and two awesome channels in a very compact package! The 15-watt MG15 includes a great-sounding 8" speaker, two switchable channels (Clean and Overdrive) with their own controls, and a 3-band EQ that lets you shape your tone. If you want to play along with your favorite tunes, this amp has a line in that lets you plug your MP3 or other music player right in! And silent practice or direct recording sounds great, thanks to a speaker-emulating headphone/line out built right into the MG15.Marshall MG15 15-watt Guitar Combo Amp Features:
- Output: 15 watts RMS
- Speaker: 1 x 8"
- Channels: Two (Clean and Overdrive)
- 3-band EQ control
- Line in for MP3 and other music players
- Headphone/line out with speaker emulation
- Weight: 16 lbs.


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The role of reactive oxygen intermediates in experimental coccidioidomycois in mice
© Margolis et al; licensee BioMed Central Ltd. 2011
Received: 22 December 2010
Accepted: 11 April 2011
Published: 11 April 2011
Coccidioidomycosis is usually a self-limited infection in immunocompentent people. In immunocompentent human beings second infections due to Coccidioides are very rare, indicating that recovery from infection results in protective immunity. In experimental animals, immunization with several different proteins or attenuated mutants protects against a virulent challenge. To explore what mechanisms are responsible for protective immunity, we investigated the course of Coccidioides infection in the gp91phox knock out mouse that has a defect in the oxidative burst that results in chronic granulomatous disease.
We found that the gp91phox knock out mice were somewhat more resistant to intraperitoneal infection and equally as resistant to low dose intranasal infection, but slightly more susceptible to high dose intranasal infection compared to control mice. The gp91phox knock out mice made a more robust inflammatory response to infection than controls, as measured by histology and production of inflammatory cytokines. The gp91phox knock out mice were as protected by immunization with the recombinant Coccidioides protein Ag2/PRA as the controls were against either intraperitoneal or intranasal infection. Coccidioides immitis arthroconidia and spherules were significantly more resistant to H2O2 treatment in vitro than Aspergillus fumigatus spores.
These data suggest that oxidative burst may not be required for protective immunity to coccidioidomycois.
Coccidioidomycosis host response oxidative burstBackground
Coccidioides immitis and posadasii are pathogenic fungi that grow in the arid soils of the southwestern United States, Mexico and Central and South America. Mycelia in the soil give rise to infectious arthroconidia, which, when aerosolized, can be inhaled. The severity of coccidioidomycois (Valley Fever) ranges from a mild self-limited disease to a severe pneumonia and widely disseminated infection requiring lifelong antifungal therapy [1]. The risk factors for the more severe forms of disease include ethnic background (Filipino, African-American, Hispanic), male sex, increasing age, pregnancy and immunosuppression (HIV, malignancy, organ transplantation) [2–4].
The role of polymorphonuclear leukocytes (PMNs) macrophages and the oxidative burst in the defense against Coccidioides is not clearly defined. PMN's are the first cell to respond to inhaled arthroconidia [5]. Although arthroconidia are sensitive to products of the oxidative burst [6, 7] and are phagocytosed by PMNs [8–10], fewer than 20% of arthroconidia are killed by human PMNs [8, 9, 11, 7]. Once arthroconidia mature into spherules they become resistant to phagocytosis and PMN killing because of their size (60-80 microns) [9, 12]. The extracellular matrix of spherules also appears to resist attachment by PMNs [9]. Rupture of spherules releases endospores that have been shown to activate the oxidative burst and are readily phagocytosed by PMN's [9, 11]. In spite of this, endospores appear to be resistant to killing by PMNs [9, 11]. There has not been an adequate study of Coccidioides in a neutropenic infection model, to understand the importance of neutrophils and macrophages on disease progression.
Coccidioidomycois is usually a self-limited infection. In immunocompentent people pulmonary infections resolve without drug treatment greater than 95% of the time [1]. In addition, human infection leads to protective immunity and some types of immunization have proven protective in mice [13–17]. We have found that the protective immunity to antigen 2/proline rich antigen (Ag2/PRA) in mice requires MHC-Class II-dependent CD4 cells but did not require CD8 T-cells [18]. IL-12 is also required, suggesting that a Th1 immune response was important for protective immunity [18]. Mice lacking interferon-γ were not protected by immunization with Ag2/PRA [18]. One issue these studies did not address was what type of effector mechanism was responsible for actually killing the fungus or inhibiting its growth. Because reactive oxygen intermediates are so important for natural resistance to Aspergillus species, we asked what role this mechanism plays in natural and acquired resistance to coccidioidomycosis using the gp91phox knock out (KO) mouse.
To address the role of the oxidative burst, we used C56Bl/6 mice with a deletion in the NADPH oxidase gene gp91. These mice were developed in 1995 by Pollack as a chronic granulomatous disease (CGD) mouse model [19]. This mouse is characterized by functionally defective PMNs and macrophages because of a mutation in NADPH oxidase in the X-linked gene gp91 phox (where phox stands for phagocyte oxidase). This gene encodes a 91 kD subunit of the oxidase cytochrome b. These mice have increased susceptibility to Aspergillus and Staphylococcus aureus infection because of ineffective oxidative killing by their PMNs. In this study we analyze the response of the gp91phox KO mice to infection with Coccidioides immitis and evaluate the response of these mice to immunization.
B6.129S6-Cybb tm1Din /J (referred to as gp91phox KO) mouse breeding pairs were obtained from Jackson Laboratory (Bar Harbor, ME) and bred in a specific pathogen free environment. Both male and female mice express the gp91phox mutation. 6-12 week old female mice were used for all experiments. C57Bl/6J female (B6) mice 6-12 week old mice were used as controls. The Subcommittee on Animal Studies approved all experimental protocols involving animals.
The R.S. strain of C. immitis was used as the challenge strain. Cultures of mycelia were harvested after 60 days. Arthroconidia were prepared from mycelia as previously described [13].
Immunization and infection
Mice were immunized with 2 μg Ag2/PRA [14] (a gift of Dr. John Galgiani) and 10 μg of CpG oligonucleotide [18] in a 50/50 emulsion of saline and mineral oil, injected in a total volume of 0.2 ml subcutaneously. Non-immune controls were injected with 0.2 ml of a 50/50 emulsion of saline and mineral oil subcutaneously. The immunization or control injection was repeated 14 days later. 14 days later (28 days after the first immunization) the mice were challenged with 150 R.S arthroconidia in 0.5 ml saline into the intraperitoneal space (I.P.). 14 days after the challenge the mice were euthanized. The left lung was removed, homogenized in 2 ml saline, serially diluted, and quantitative culture done.
Pulmonary infection was initiated with 150 or 250 arthroconidia intranasally in 20 μl saline after mice were anesthetized with ketamine and xylazine (0.1 ml of a cocktail containing ketamine (15 mg/ml), xylazine (16 mg/ml) in saline was injected i.p). After infection, they were rested on a heating pad and monitored until they woke up in about 1 h. The mice were monitored for mortality for 30 days.
Real-time Quantitative PCR for Lung Cytokines
Groups of 4 mice were infected with 150 arthroconidia I.P. Twelve days after infection the upper lobe of the right lung of a mouse was removed into 2 ml Ultraspec (Biotecx) and immediately homogenized. Total RNA was extracted as described in the manufacturer's protocol. RNA was quantified and analyzed for integrity using a Bioanalyzer (Biorad Experion). cDNA was synthesized using superscript VILO cDNA synthesis kit (Invitrogen). Taqman gene-specific primer/probes for mouse cytokines and 18S were purchased from Applied Biosystems. The real-time quantitative PCR reactions and data analysis were carried out by UCSD CFAR genomic core according to the manufacturer's protocol using an ABI Prism 7900 HT sequence detection system. Amplification of 18S RNA was performed to standardize the amount of sample added to each reaction.
Susceptibility to Oxidative Stress
Aspergillus fumigatus spores were harvested from mature slants in distilled water. C. immitis arthroconidia were harvested from mycelia by beating with glass beads as previously described [13]. C. immitis spherules were grown in modified Converse media for 7 days as previously described [20]. About 200 organisms were incubated with various concentrations of H2O2 in 1 ml saline for 45 minutes at room temperature. The fungi were collected by centrifugation, washed in saline by centrifugation and the sediment cultured on glucose yeast extract agar. The number of colonies was counted and compared to a control that was processed as above but not treated with H2O2. Each experimental point was determined in triplicate; the mean and S.E.M. is plotted.
All quantitative culture data and quantitative mRNA data was compared using the Mann-Whitney U test. Survival data was analyzed by the Kaplan-Meier test. Both tests were done with Prism GraphPad 4 software (San Diego, CA).
The objective of this study is to determine what effect the deletion of gp91 phox had on the innate and acquired immune response to Coccidioides. We examined the responses to two different routes of infection: intraperitoneal, which is not physiologic but has quantitative culture as an endpoint, and intranasal resulting in primary rather than hematogenous pulmonary infections. In the latter model mortality was the endpoint. Although intraperitoneal infection is not the physiologic natural route of infection, the studies done so far in many laboratories have not identified any major differences in the immunological protective mechanisms required for coping with intraperitoneal versus intranasal infection. In both circumstances T-cell mediated immunity is required and a Th-1 immune response is important [18, 21, 22]. Furthermore, the genetics of resistance to Coccidioides infection by these two routes is very similar (unpublished observation) [10, 23]. The only significant difference documented between the two routes of infection so far is that some vaccines that are protective in the intraperitoneal model are not protective in the intranasal model [24]. C57BL/6 mice are extremely susceptible to intranasal infection with Coccidioides so that very small difference in inoculum can have major effects on mortality rate. We have found that the intraperitoneal route of infection is more reproducible and predictable, so we chose to do preliminary experiments using this model. In both these infection models, the gp91 phox mutation had no effect on acquired immunity to Ag2/PRA. These data suggest that reactive oxygen intermediates may not be required for protective immunity.
The situation in non-immune mice is less clear. In the intraperitoneal model of infection, the gp91phox KO mice had significantly fewer organisms in their lungs compared to the controls. This may be due to the more exuberant inflammatory response seen in the gp91phox KO mice compared to the B6, as measured by histology and amount of Th1 and Th17 cytokine mRNA in the infected lung. In the intranasal model of infection, no difference between the gp91phox KO and B6 was seen when the mice were challenged with 150 arthroconidia, but there was a small difference in survival between the two mouse strains when they were challenged with a larger number of organisms. The increased mortality rate may also be due to a more vigorous inflammatory response in the gp91phox KO mice.
We also found that C. immitis arthroconidia and spherules were significantly more resistant to killing by H2O2 than Aspergillus fumigatus spores. gp91phox KO mice are susceptible to pulmonary Aspergillus infection, so this is a potential explanation for the difference in susceptibility of the gp91phox KO to these two fungi. However, since it is not clear that ROI kill fungi directly (see below) the significance of this observation is not clear.
More studies in CGD mice have been done with the gp47phox KO rather than the gp91phox KO. Mice with both mutations have the CGD phenotype but there may be differences between the two. The observation that gp47phox KO and gp91phox KO mice make a more robust inflammatory response than control mice with an intact respiratory burst has been previously made in mice experimentally infected with Aspergillus fumigatus [25] or in mice given intra-tracheal zymosan [26, 27]. The mechanism of this exaggerated inflammatory response to Aspergillus fumigatus infection was thought to be a defect in a superoxide dependent step in tryptophan metabolism [26]. The exaggerated response to zymosan in gp47phox mice was thought to be due to a failure to activate Nrf2, a redox-sensitive anti-inflammatory regulator [26].
The mechanism by which phagocytes inhibit and damage fungi is complex. NADPH oxidase is not required for phagocyte killing of Aspergillus fumigatus conidia [28, 29]. This growth phase of Aspergillus fumigatus is inhibited by lactoferrin-mediated iron depletion [28]. In contrast, inhibition of the hyphal form of Aspergillus fumigatus requires NADPH oxidase [28, 30]. Aspergillus nidulans lacking the catalase genes are capable of causing disease in gp47phox KO mice, which suggested that reactive oxygen intermediates might not be inhibiting the organism directly [30]. It has been suggested that activation of intracellular proteases by reactive oxygen intermediates is important for killing Candida and several types of bacteria [31]. There is one report that administration of pentraxin 3 protected gp47phox mice from experimental Aspergillus fumigatus infection, suggesting that this molecule in important for resistance to Aspergillus fumigatus and may be lacking in CGD mice [32].
The only evidence that primary pathogenic fungi are more virulent in CGD mice is a study with Sporothrix schenckii [33]. These investigators found that gp91phox KO mice infected with Sporothrix schenckii intradermally died within three months, whereas control mice survived this infection. They also found that PMN from gp91phox KO mice were not able to control the growth of Sporothrix schenckii as well as the controls. We have not been able to find any published data on Blastomyces dermatitidis, C. immitis or Histoplasma capsulatum experimental infections in CGD mice.
People with chronic granulomatous disease have increased susceptibility to Aspergillus infections and, to a lesser extent, infections due to other opportunistic fungi [34]. There have been no reports of increased susceptibility to the primary pathogenic fungi Coccidioides, Histoplasma capsulatum, Blastomyces dermatitidis or Sporothrix schenckii. One expert states that these infections are not a problem in chronic granulomatous disease [34]. One CGD patient has been observed to recover uneventfully from pulmonary coccidioidomycosis without anti-fungal therapy (J. Galgiani, personal communication).
The observation that NADPH oxidase is not required for a protective immune response to experimental coccidioidomycosis raises the question of what immune mechanisms used to kill spherules and endospores in vivo. One potential protective immune effector mechanism is oxidative stress due to nitric oxide. We have previously reported that IL-10 exacerbates the course of experimental coccidioidomycois and inhibits nitric oxide synthase [35]. On the other hand, a very recent study suggests that Coccidioides is resistant to killing by NO and that mice with a deletion mutation in inducible nitric oxide synthase are able to kill Coccidioides [36]. Coccidioides spherules can be very large (more than 60 μM in diameter) and therefore difficult to phagocytose. Perhaps inhibiting the growth of the endospore controls the growth of the organism. Understanding the mechanisms of protective immunity is important for optimally preventing and treating infections with this pathogenic fungus. These finding may also be relevant for other primary pathogenic fungi, such as Histoplasma capsulatum and Paracoccidioides brasiliensis.
Mice with the CGD phenotype are not more susceptible to Coccidioides immitis infection and they are completely protected by effective immunization. This suggests that some mechanism other than reactive oxygen intermediates may be responsible for protective immunity.
List of Abbreviations
Chronic granulomatous disease
Reactive oxygen intermediates
α - Tumor necrosis factor-α.
The Research Service of Department of Veterans Affairs provided funding for these experiments. David Margolis was supported by grant T32 AI007036-31A1.
We thank Mark Ashbaugh for his technical support, Dr. John Galgiani for his gift of Ag2/PRA and Dr. Parviz Haghighi for reviewing the pathology and obtaining the photomicrographs.
Authors' Affiliations
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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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(33 quotes found)
"I don't know how good Winter Springs is, but it concerns me that Mainland is getting touchdowns from special teams and defense. If we fumble like we did tonight, (Mainland's) Tony Wilson picks it up and runs it back and it's already 7-0."
Howie DeCristofaro
"Our island has been the source of eagles for both mainland populations and northern islands. It's possible that pair bonds will break. It's taken us 25 years to get to the point that we're at."
Ann Muscat
"The takeover will help us tap the neighboring overseas market, which has an environment similar to the Chinese mainland."
Wang Jianzhou
"We definitely want them (visitors from the mainland) to come back."
Bill Earnest
"The idea is to stop this problem before it gets out of hand like it has on the Mainland."
Bob Loy
"I agree mainland China's situation is different. The Vatican may make concessions and let China give its opinion, but it won't let Beijing have total say."
Cardinal Zen
"It's been a long time since I had a Chinese-language movie show in the Mainland, but everyone still remembers me. Thanks for giving face."
Chow Yun-Fat
"It costs about $80 each way to bring your board to the mainland. If you travel only like two to three times a year, you're already making up your money [for the rented space]."
Daniel Perez
"The mainland will oppose strongly Chen's move, which tries to reverse historical trend. The international community would not support him because he is creating tension in cross-Straits relations."
Yu Keli
"The timetable is in the hands of the mainland, even more so in the hands of Taiwan's new leader, and frankly speaking in the hands of Taiwan's voters."
Xu Bodong


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"Why buy good luggage? You only use it when you travel."
Yogi Berra
"love to travel, But hate to arrive"
Albert Einstein
"When you're travelling, you are what you are right there and then. People don't have your past to hold against you. No yesterdays on the road."
William Least Heat Moon
"And she's very easygoing when she travels, ... She's traveled on planes, cars and trains."
Sarah Hamilton
"Sometimes the road less traveled is less traveled for a reason"
Jerry Seinfeld
"Man cannot discover new oceans unless he has the courage to lose sight of the shore."
Andre Gide
"I took the road less traveled by, and that has made all the difference."
Robert Frost


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DON'T Children's Book
DON'T Children's Book
Curiosity, humour and the light-hearted are key elements to my work. By mixing handmade marks with digital processes I produce a visual language which is bold and graphic. I'm particularly fascinated by people, their individual stories and the nostalgia of childhood.
My brief was to produce a short simple tale aimed primarily at children aged 3-5 years old. This was my entry for the Macmillan Children's Prize. The idea of 'DON'T' originated from a child running upto me for a cuddle, and the mother telling her not to do this to strangers. I aimed to explore dangers children face and behaviour in a humorous, fun and light-hearted way.


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Oxford Diecast Maroon/Ivory Riley Kestrel - 1:76 Scale
Product Code: 76RK002
Riley was a household name between 1890 - when William Riley Jr purchased the Bonnick Cycle Company in Coventry - and the end of the line in 1969. William named his initial company the Riley Cycle Company in 1896. However, running alongside his cycling manufacturing, which catered for the cycling crazy customers of the era, his son Percy, was tinkering with the development of automobiles and secretly built his first car in 1898. By 1913, Riley Motor Manufacturing was launched, growing sufficiently to be bought by the Nuffield Organisation in 1938, later merging again with British Leyland. The last Riley-badged car rolled off the production line in 1969. The Riley marque is now owned by BMW. The Kestrel 12/4 had a very short life, being made solely between 1934 and 35. This light saloon had a top speed of 73.6 mph and could reach a speed of 50 mph in 19.2 seconds. The fuel tank held 10 gallons and fuel consumption was 28.3 mpg. Costing £345 back in 1934, surviving examples are now being auctioned at around £25,000.
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My first memories of misery were when I was very young. My mom, who loves fur coats, bought me a white rabbit fur coat. I'm sure it's because she thought it was cute, but in all reality, all it did was give me itchy eyes, a runny, raw nose, and a bad case of wheezing. I hated that coat...I have not outgrown my allergies to fur. As a matter of fact, I cannot be around cats for any period of time, and I am also allergic to most dogs. The only pet I have ever had that didn't make me break out into hives was my beloved Shih-Tzu, Mojo.
On top of severe allergies to anything furry, I also suffer from horrible seasonal allergies as well. I cannot be around pollens of any kind or freshly cut grass without loading up on allergy pills beforehand. This is very counter-productive, since all they seem to do is put me to sleep and that totally defeats the purpose of enjoying time outdoors with my family. What good am I if I can't stop sneezing and can barely keep my eyes open? Also, I hate taking medication if I can help it. Yep, I am stubborn that way and tend to lean more towards natural and homeopathic remedies.
Another bad side-effect allergies and sinus problems can have? Sinus infections. I get them far more often than I would like. A bad sinus infection will have me grumpy, grouchy, whiny, and laid out for at least a week! And when I get sick, everything falls apart. The house ends up looking like a hurricane hit it, dinners come out of the freezer or take-out bag, and the kids end up getting into more mischief under Daddy's care than I would put up with myself.
That's why I was thrilled to be able to try the SinuSense Water Pulsator by Waterpik. I had never tried a neti pot before, let alone a water pulsator, so this was a new experience for me. The SinuSense massages, cleans and moistens your sinus passages with the gentle, pulsating stream of water or Soothing Saline solution. It provides maximum cleaning with a sensitive touch.
I have been using this product for about a week now. It arrived just in time for the onset of my springtime allergy suffering. While the idea of shooting a stream of fluid up my nasal passages seemed odd initially, I was pleasantly surprised at how soothing and comfortable the whole process was. It was truly like getting a massage for my over-worked, inflamed sinuses! The Soothing Saline solution, which includes aloe vera and eucalyptus, even helped to relieve uncomfortable sinus pain better than my traditional allergy medication does.
The SinuSense is battery operated and holds up to 8oz of solution. A proper cleansing only takes 20 seconds, so it's a very quick process! It is also easy to clean, dishwasher and microwave safe, and is BPA-free as well. Talk about convenience!
This product has quickly become a go-to weapon against sinus pain, pressure, and allergies. I have noticed a huge difference in the way I feel in a very short period of time. I also love the fact that this is a far more natural way to deal with my many, many sinus related issues. I would definitely recommend the Waterpik SinuSense to anyone who wants to get real relief from their seasonal allergy woes.
You can check out the SinuSense on the Waterpik website.
You can also find several valuable coupons HERE.
You can also follow Waterpik on Facebook, on twitter, and on YouTube to stay on top of their latest products and promotions!
***Disclosure: I received complimentary products as well as compensation for this campaign. However, all opinions are 100% honest and have not been influenced in any way.***


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Sunday, November 16, 2008
SFX December 2008
Nice profile piece on me in the December 2008 issue of SFX, with a full page picture too (inside, not that scary-eyed depilatephobe on the front cover). I can't say it was much fun posing in the pissing rain on the Mayland mud flats, but the result seems pretty good. I'd just love to know how the other more ambitious photos of me posing against a wall of scrap turned out. That picture could have had the tagline: here is Neal Asher superimposed over a view inside his head.
Science Fiction
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- //Home
- //Music
- //Reviews
- //Kate Rusby
Kate Rusby, reigning queen of the traditional English folk song, knows how to sing a story. On her latest, The Girl Who Couldn't Fly, she weaves gold into folklore, making music that seems anachronistic, yet makes the listener want to join her on a journey to another world. While this site offers the latest thoughts on everything modern from grime to Mario Kart DS, Kate Rusby offers us a classic voice, some thoughtful instrumentation, and the promise of a beautiful day.
First and foremost, Rusby sounds as if she could sing nothing but folk music. Her voice, and especially her use of it, well suits a song style that is expressionistic without being overpowering. The way she sings serves to highlight how many vocalists out there choose merely to get the words out, without simple regard for the sound. One could get lost in her warm technique—she neither over- nor under-sings.
And then there are the songs. This time around, Rusby has written seven of them, with the remaining five being some form of traditional composition (whether overall, or in lyrics). Her original songs blend beautifully with the older selections; her writing style is simple and poetic. Anyone who has spent time listening to folk records of any sort knows how hard it is to take the old and new, side by side, and craft it into a whole. Rusby, whose past records spoke to the difficulty of this undertaking, has finally jumped the line. The album's excellent sequencing is part of it but would be nothing without the obvious growth spurt in her compositions.
The promo materials for The Girl Who Couldn't Fly claim the title is a reference to Kate Rusby's fear of airplanes. Nowhere is there mention of an overall theme, but perhaps that is because the listener must hear it for themselves. Just about every song speaks of a woman who is stuck in a situation. Whether it's love, death, or fate that has kept her in one place, there she is with nowhere else to go. This theme becomes powerful as Rusby's songs veer from straightforward storytelling to a more impressionistic narrative. Top that off with the unnerving angelic quality of her voice and the carries power: power to accept one's lot in life, power to transcend death in order to relive the story.
It goes without saying that The Girl Who Couldn't Fly is a specific style of record that may not appeal to everyone. That should make it only more special to those who will appreciate it with its limitations. Kate Rusby has stuck to a formula all these years, and is improving upon it. To those who wish to delve into the precision of genre-music, you'd be the better for hearing this record.
Tibet House's 30th Anniversary Benefit Concert Celebrated Philip Glass' 80th
// Notes from the Road
"Philip Glass, the artistic director of the Tibet House benefits, celebrated his 80th birthday at this year's annual benefit with performances from Patti Smith, Iggy Pop, Brittany Howard, Sufjan Stevens and more.
READ the article


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Invaluable cannot guarantee the accuracy of translations through Google Translate and disclaims any responsibility for inaccurate translations.
Lot 369: Japanese WWII Shin Gunto Katana
Autumn Outstanding Antiques & Fine Art Auction
by Bruneau & Co. Auctioneers
October 29, 2016
Cranston, RI, USA
Live AuctionDescription: JAPAN, CIRCA 1930 A fine Japanese World War II Shin Gunto mounted Katana. The blade is a fine example of a pre war oil tempered blade with an active Hamon. The blade is matched with war time mounts. The tang is signed and bears an arsenal mark.
Condition Report: Blade was stored with thick oil and has been preserved beautifully, then felt with the fingernail about 6" from end you can feel the slightest area of imperfection, so minor!. All furniture in good overall condition, a very well preserved sword.
Provenance: A very fine and well preserved sword!
Dimensions: blade overall measures 34 7/8" long, sharpened area measures 26 15/16", together measures 40 1/4" long.


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text:
Who's the Boss Game #2954 : Who's the Boss: My first game!< Back to the game listThis game is moderated by Thekid4. Please read the rules and contact the moderator with any questions or concerns about this game. Voting / Memo DiscussionThis game finished in 5 rounds. Players
Memo #1 from the Boss Alright, yall , get to work. Psych Question: Do you own any pets? Does a kid brother count? |


text:
An old buddy of 26 years was in NYC for business last week. So I rode my bike (Roman Holiday) to meet him at the train station.
Something popped in my mind.
You see, Roman Holiday is the same exact bike I had in college 26 years ago. Back then, my nightly routine consisted of: study in the library until about 11 pm and then a few "buckets" of beer at the college pub, which was located below the library.
Then around midnight or so, I would hop on Roman Holiday for a quick 5-minute ride home. Unlocking my bike and riding home, while hitting all of the green lights, was the best part of my day.
Back to present.
I get my buddy back on a NYC-bound train and then I unlock my bike. With a few pints in my belly, I saddled up on Roman Holiday and blow through town. I'm home in no time.
As I'm flying through town, I am instantly transported back to my 1980's college days.
Bikes remind you of the past and move you forward at the same time.
Tuesday, October 28, 2008
3 comments:
- the original big ring said...
the second best part is you drank beer!
- Roman Holiday said...
Bikes and Beer = fun, but be safe out there.
- Groover said...
Great post. Makes me all nostalgic. :-)
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