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BBos7 Home search function? I'm a new user transition from BBos5 to BBos7.The one thing that is really letting me down, is how BBos7 behaves when searching on home screen. I used to find it one of the best features of BBos5 when you could just type someones name and have it appear instantly like so. Now on BBos7, the search from homescreen looks so weird. Even if you deselect every search feature except contacts it still doesn't feel as neat and helpful. I really hope there's a way to make it appear as it was before, that i just haven't found yet! Is there any way to make it appear like before? |
Re: BBos7 Home search function? I believe you would be better off not using the homescreen search to look up a contact. The first image you post is from the phone app, correct? Is that how you are used to doing it. If already using the phone, that's they better way to do it rather than going the search route. And if you are going to compsose a message, go to the compose screen and begin to type the contact in the appropriate field rather then go to search as the first step. Posted via BlackBerryForums.com Mobile |
Re: BBos7 Home search function? The OP has the Dial From Home Screen option enabled. In my ancient os 4.5 you can find it under: phone - options - general options http://s1223.photobucket.com/albums/...OTUxLmpwZw.jpg I hope this is available in os v7.1. I will be upgrading my device too and I use this feature all the time. Posted via BlackBerryForums.com Mobile |
Re: BBos7 Home search function? No. The OP does not have dial from home enabled. What you have with OS 4.5 is irrelevant. OS 7 (and OS6) can be set to either launch universal search when typing on the homescreen, or application shortcuts. Posted via BlackBerryForums.com Mobile |
Re: BBos7 Home search function? What I meant was that the OP apparently had Dial From Home Screen option enabled on his old device running os 5.0 and is trying to get the same functionality on his new device running os 7.1. Even if this feature is no longer directly supported in os 7.1, there might still be some settings trick that would bring this behaviour back. Posted via BlackBerryForums.com Mobile |
Re: BBos7 Home search function? I've used application shortcuts pretty much all along, but so far as I know, dial from home is gone. As I say, the dial from home option in the phone app settings is replaced by homecreen option settings to either launch universal search when typing or application shortcuts. So, the "trick" is press the phone button and start typing contacts name. If I'm wrong, someone will correct me. Posted via BlackBerryForums.com Mobile |
Re: BBos7 Home search function? No i think what you're saying is correct. You have to press phone, name and then phone again to call someone now. So additionally you got to press the phone button twice. Once before and once after you start typing the name. Personally that's one too many for me. I dont like the universal search. I'm not a searching kind of guy, and i liked it previously on Bold 9000 where you could just get the device on your hands and start typing the name on the home screen pressing call and have the call initiated at once. Why did they have to make it awkward damn it? |
Re: BBos7 Home search function? I agree with you. My view for what it's worth is the market is going all touch and the keyboard BlackBerry models have been losing the optimization for keyboard for a while since the touch models started coming out and the OS was being tailored along the way for the touch screen. There are many examples with keyboard and app shortcuts that have been dropped or changed for the worse. I expect the BB10 hard keyboard series will seeming to be a touch model with a keyboard patched on as an afterthought. Posted via BlackBerryForums.com Mobile |
Re: BBos7 Home search function? Well sadly that the case. I just didnt expect the RIM would sell their soul to the devil as well, and go with the touch smartphone norm. BB devices are the last of the button type and i hoped things would stay that way, seeing as they advertise their product line as communicators. Well maybe times have changed and communication today is done via smartphone apps and multitouch screens :( |
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On the fifth day of Chinese New Year, I had another liondance performance. This time it was at a Chinese restauarant in downtown Ottawa, the name of the restaurant is Palais Imperial Chinese Restaurant. It was for the Taiwan Students Association for University of Ottawa. Here's the group photo after the performance.
Before the performance, I had a three hour hang out at Rideau Centre because it has been awhile I had shopped around due to the bus strike. It's great that the bus strike has ended but the worse part is waiting until February 9 for buses to resume into service. Aside from the bus strike, what struck me by surprise at Rideau Centre were several empty stores. It was almost depressing to see it because of the downtown in the economy. What did I check at Rideau Centre? I was looking for Blu-ray movies but they did not have the one I was looking for. I only ended up getting an Orangesicle from Booster Juice.
After the performance, our group went to Ben-Ben Restaurant on Somerset St. (aka Ottawa Chinatown) for some Chinese food. I also forgot that Raw Sugar Cafe (across from Yangtze Restaurant) had an event. It was event for the launch of Dharma Arts. I didn't expect to see a friend of my brother's (he's a professional photographer) be there. It was totally last minute for me because I wasn't expecting to go down to Somerset St./Chinatown. It was nice to drop by and a surprise to see Rolf Klausener of The Acorn to be working at Raw Sugar Cafe. I did not get to see another photographer if he was suppose to appear, as I only hung around for not too long. I was totally full from the food at Ben-Ben Restaurant.
Well, I can't wait to take part of the performance at Pembroke on Saturday.


text:
This is a selection of books with introductory/review comments made about them by Glamorgan and Dyfed Mailing List subscribers, the contributors' names follow their final submission.
Some entries contain a list of the chapter headings and/or a verbatim copy of the book's own introduction, some also have an online index of the names contained in them.
There are two pages of titles, see also the second page
Alphabetical list of titles on the first page
- 1. "History of Wales" by John Davies is the classic of course, and was written first in Welsh as "Hanes Cymru".
- 2.For those who find it a bit dry and academic try his later book "The Making of Wales", published by CADW in 1996, which is lavishly illustrated with colour photos, maps and sketches and it's a much easier read covering the history of Wales from the "Red Lady of Paviland" of Palaeolithic times right up to1995.
- 3. For those Welsh-speakers among you Gwynfor Evans' book "Land of My Fathers" [ISBN 0-86243-265-0]came out first as "Aros Mae" [It Endures] in1971 and is still in print. Gwynfor himself autographed my copy. He is a lovely gentleman, enjoying his well-deserved retirement in the depths of his much-loved rural West Wales.
See below for a full Contents listing.
Those of you who remember HTV's series on Welsh history in the 1970s "The Dragon Has Two Tongues" will remember those lively and stimulating discussions and exchanges of views between Wynford Vaughan Thomas [see below] and Professor Gwyn Alf Williams. They really did see Welsh history from two opposing viewpoints! I really enjoyed Gwyn Alf's subsequent book "When was Wales", published by Penguin Books in 1985, reprinted as late as 1991. On the front cover the subtitle says "The history, people and culture of an ancient country." Highly recommended particularly if you like history from a more unconventional viewpoint. When Gwyn Alf was Professor Emeritus of History at the University in Cardiff students would actually queue up and pack the lecture theatre as his lectures were so fantastic and stimulating. No one would know what he would say next. With his untimely death three years ago Wales and its people lost a great champion of their cause.
Volume 3 Edited by Geraint H. Jenkins and Ieuan Gwynedd Jones, published by University Wales Press, Cardiff 1998. This is a "must-have" for anyone with Cardiganshire ancestors as this is a mine of information in 633 pages. It covers the period from the beginning of the eighteenth century up to 1998. There are 26 chapters on social, cultural, political, religious, educational aspects of life in Ceredigion as well as the Welsh Language,agriculture, industries, ships and shipbuilding, house design and architecture, poor law administration,and tourism etc. It is lavishly illustrated with colour and black and white photographs, drawings, maps, charts and tables. Rather an expensive buy at £60 but copies are available for consultation at libraries . I had mine somewhat cheaper by subscription and it was my bedside read for many weeks. Some chapters were so fascinating I burnt the midnight oil in order to finish reading them.
By Major Francis Jones, published by Brawdy Books in 1997 is another book I subscribed to as it has a lot of local interest for me. There are over 600 houses and 2000 families detailed alphabetically throughout the county. Ordnance Survey grid references are given for each property, a history and description of the house and any estate, genealogies of the families and useful references for further research.
- 7.There is also a similar book written and published by the same people for those with Pembrokeshire connections Historic Pembrokeshire Homes and their Families.
By Eifion Evans, first published 1969 and reprinted yet again in 1996 by The Evangelical Press of Wales. Until comparatively recently the majority of the population attended either chapel or church in Wales. Following the great Methodist Revivals of the latter part of the eighteenth century and subsequent revivals in the nineteenth and early twentieth centuries Wales became a land of chapels, large and small, in town and isolated rural uplands. I remember an elderly uncle of mine, who was a young boy at the time of Evan Roberts last great Welsh Revival of 1904, telling me of the overflowing chapels and prayer meetings uinderground at the pit.. This revival started in rural Ceredigion, in New Quay, in Blaenannerch, in Newcastle Emlyn before spreading like holy fire to the industrial valleys of South Wales. This book gives a clear, good, if rather studious background to those Bethels, Bethanias and Zions throughout the land, many of which were rebuilt or extended after 1904, only to start declining after World War1. Many people do not realise that this revival had a ripple effect in England, Scotland and further afield as in the mission fields of India and Madagascar.
By Prys Morgan and David Thomas, published by David and Charles in 1984. This is a general and cultural history of Wales. The authors show the distinctive characteristics which differentiate Wales from its big brother neighbour, England. As well as describing rural and industrial Wales they also talk about "The Dragon's two tongues", The land of song, and Rugby. In the appendix there is a short history of Welsh Surnames and a useful chronological table comparing the timetable of events in Wales compared with the rest of the UK and also the wider world :for instance in1801, the census showed the population of Wales was 587,000, in the same year there was the Union of Great Britain and Ireland, while abroad, Napoleon was in power in France and at war with England, culminating in the Battle of Trafalgar in1805.
An online index and review by Mary Jane Stephenson is available on INDEX
By Paul.R.Davis published by Christopher Davies in 1992. Another book about West Wales, covering Carmarthenshire and Pembrokeshire. It is mainly a tour about 150 places such as prehistoric monuments, churches, castles,wells and old houses. They are all indexed, O.S.grid references given and also locations are shown on a sketch map. There are black and white photographs and sketches illustrating this useful book if you are interested in the background history of West Wales although much of it refers to older times than I have found on my family trees.
Welsh Life and Customs from Prehistoric Times to the Present Day.By A.H.Todd published by B.T.Batsford Ltd in 1979, reprinted several times, mine is 1987. This is a comprehensive general history beginning with the earliest inhabitants and relating the main historical happenings in Wales up to World War 1 with as an epilogue sketching subsequent events. This is a readable, quickly-read book which gives the background history Of Wales and her people, illustrated with black and white contemporary drawings. It is often a good idea to read a short history like this before tackling John Davies' "A History of Wales" so you get the general picture before filling in on the details.
By Susan Passmore, published by Dyfed County Council in 1992. An essential and informative book for anyone with ancestors in New Quay and surrounding areas in Cardiganshire in the 19th century. Full of names, places, ships and events with a comprehensive index, it is a very interesting source of information and there are plenty of references and a bibliography for further research. Of particular value is the list of ships that were built or sailed from New Quay but, in addition to all the information to do with the sea and associated trades, there are details of farming, education, religion and politics.
- 14. Gwalia in Khasia
By Nigel Jenkins, published by Gomer Press in 1995. Did you have an Welsh ancestor who was missionary in India? Until Nigel Jenkins wrote this book the story of the 200 Welsh Calvinist Methodist missionaries who toiled for many years in the mountainous area of the Khasi Hills in North East India had largely been forgotten or ignored. As a result of his research, programmes on Khasia were broadcast in Welsh and English on S4C television. Unfortunately there is no index of names of the preachers, ministers, missionaries, wives and children in this book but there is a bibliography for further research. There is quite a lot of history about the families while they were in India and details of their descendants and also where they died and were buried. The first of the missionaries was Thomas Jones from Montgomeryshire who arrived in 1841, and 150 years later a quarter of a million people gathered in Shillong, the capital, to celebrate and mark the anniversary. The missionaries went from all parts of Wales and many never returned: the death of one far from home is recorded on a gravestone in New Quay churchyard. The last ones left India in 1969 leaving many legacies of Christianity, Bibles and hymn singing.This is an interesting book written in Nigel Jenkins inimitable style.
By R. Iestyn Hughes and Paul O'Leary.
Published by Sutton Publishing, in conjunction with The National Library of Wales, 1999. A beautiful book, yes really. Fabulous photographs from the National Library of Wales' extensive collection with text taken from contemporary records I saw this book, which had just arrived in Fred Coopers Bookshop in Newcastle Emlyn last week and bought it straightaway as I found it so fascinating. Who was it who said that a picture is worth a thousand words? And anyway, you 've got the words as well here; from sources such as newspaper archives, council reports, books, Royal Commission extracts. It is rather expensive at £18.99 but is well-bound on high quality glossy paper which does justice to the photographs, which cover all areas of Wales, North, South, Mid and West Wales. There are nine chapters on subjects such as Industry and Commerce, Rural Society, Culture and Religion, Travel, Entertainment, Politics. This is not a criticism of the book as most of the people portrayed are ordinary folk so have not left their names for posterity but I would love to know who are they, these people who look out at you from the past.There's Llanilar Sunday Scool in 1913, trams in Swansea in 1893, the staff at Lipton's shop c1910, a slate splitter in the 1880s, Evan Roberts c1903 and many, many more, After reading this book you get an overall picture of the dramatic social changes that have occurred here in Wales over the last century.It's the kind of book one would like to receive as a gift for a birthday or Christmas.
- 16. Historic Rhondda
By Paul R. Davies, published by the author in 1989. I bought this local history book from Paul when it was first published as, at that time I lived in Tonyrefail, just outside that fascinating part of Wales, the Rhondda. The history in this book begins in prehistoric times, travels through the Roman period, Dark and Middle Ages, post-medieval and up to 1850. There are many maps, sketches, plans of buildings and black and white photographs. An interesting book for anyone who had ancestors living in the Rhondda to get a feel of how the area was in the days before King Coal came and desecrated what was a beautiful, off-the- beaten-track place. Unfortunately there is no index at the end but included is an inventory of sites and monuments.Many of the farm builings still standing and lived in today are hundreds of years old and some of these, such as Tyntyle, Ffynnon-dwym, Gellifaelog, are illustrated and their history described. Chapels and early industrial feature as also do boundary markers, castles, dykes and early settlements.
- 17. Crwydro Sir Gar
By Aneurin Talfan Davies, published by Llyfrau'r Dryw in 1955, reprinted 1970. This book is an account,in Welsh, of Aneurin Talfan Davies' travels around Carmarthenshire in 1952. Reading this, one is struck by how much the rural scene in this county, where I now live, has changed in less than half a century. There are local people living here that I chat to, who can remember a time before tractors, when to see a car was a rarity and the English language was seldom heard, and in this account one can imagine vividly how it used to be before so many incomers flooded into the county, especially in the 1970s and 1980s .............
By T.I. Ellis, published by Llyrau'r Dryw in 1952, Like "Crwydro Sir Gar" this is the account, in Welsh, of travels around a county. Interestingly, the author has used the ancient name of Ceredigion when, at that time, the county was known as Cardiganshire or Sir Aberteifi. Of course, since the latest local government reorganisation, after having been part of Dyfed for a period of around 20 years,the county is again known as Ceredigion. The author starts off in 1947 by exploring Aberystwyth and relates the history of the National Library, then follows the rivers Rheidol and Ystwyth up into the mountains. He visits, amongst many other places,the atmospheric Ystrad Fflur (Strata Florida),Mynydd Bach, the Georgian streets of Aberaeron, the Teifi valley and across to Llanarth and Y Wern, where Henry VII stayed on his way to the Battle of Bosworth, Cei Newydd (New Quay), finishing the book in Aberteifi (Cardigan). Unlike "Crwydro Sir Gar" this author does not relate conversations with local people, but is more like a travelogue; he seems more interestesd in the places than with the people. However, the book gives a fairly detailed background as to the history and geography of this mainly rural county some fifty years ago.
- 19. The Drovers' Roads of Wales . II Pembrokeshire and the South.
By Shirley Toulson and Caroline Forbes published by Whittet Books Ltd in 1992 This is the second book, unfortunately I do not possess the first, and covers from the Englishry of Pembrokeshire around Angle and Castlemartin up through Carmarthenshire, across from Ceredigion through Gower into Glamorgan and over the Black Mountains into the Welsh Marches. It was written as a guide for walkers but covers much of historical interest. The Welsh drovers avoided the main toll roads in the valleys and travelled across the hills using routes that you can follow today. There is a useful bibliography for further reading and an Index of people and places. Stories of the Rebecca riots of the 1840s are told in several places, the legend of the physicians of Myddfai and did you know that William Edwards who built the bridge at Pontypridd also built the bridge at Cenarth? There are maps and lots of black and white photographs that make this a useful book for background information.
By H.V. Morton published by Methuen in 1932 .This well-known book has been reprinted many times over the last sixty years and was one of a series of travel books by the author. Many things have changed in Wales since it was written but it is worth reading to see Wales impressing a stranger wandering across the country. He did not just look at the scenic areas but also visited the coal-mining valleys of the South and even ventured to visit the National Eisteddfod at Bangor and devoted a whole chapter to an account of it. The author enjoyed meeting the Welsh people, was sympathetic to them and encouraged them to tell stories and relate happenings which provide variety of content to an otherwise rather old-fashioned style of writing.
By Francis Jones, published by Brawdy Books 1998. This is the third book in the series; the previous ones were about the historic houses of Carmarthenshire and Pembrokeshire. The next one due, which I am looking forward to with much anticipation, concerns Cardiganshire homes. However, this latest offering contains much of interest to those with Pembrokeshire ancestry even though, unfortunately, there is no index to people and places. Throughout his long life, Francis Jones met interesting people, went to historic places and collected facts,stories,details of events, and researched ancient records throughout record offices and repositories in Wales and London. He was an acknowledged expert in the field of Welsh genealogy, local history, heraldry and antiquarianism. After his death in 1993 his family spent much time and trouble extracting from his research items suitable to publish in book form. This book gives a picture of the history of Pembrokeshire from Norman times up to the 20th century, stories about ancient homes and families, castles, churches,dissent,farming, Pembrokeshire military men, litigation, sportsmen and even an account of the author's father in Patagonia around 1880. A good read.
By Iorwerth C. Peate, published 1942, 3rd reprint 1998, by Gwasg Gee. Iorwerth Peate was the Curator of St Ffagans Folk Museum, now renamed the Museum of Welsh Life, and this book is about "The Culture of the Welsh People." It is an academic book, written in literary Welsh, that gives a fascinating insight as to how our Welsh ancestors lived, loved and died. There are no illustrations in this book which was originally published in the austere years of World War II and five years before the opening of St Fagans. Iorwerth Peate discusses the concept of culture and examines the traditional house of the ordinary people, their sparse furniture, the hearth, centre of the home, and cooking. He looks at what the people wore, their religion, education, games, pastimes, their cultural life. Agriculture and crafts, folk-lore and customs concerning birth, courting, marriage and death in the family and community, as well as traditions and legends have all been researched and written down for posterity.For the family and local historian this book is a valuable resource of background information about the lives of ordinary Welsh people. It would be a good book to read before a visit to St Fagans, which is a very useful place to go and see the kind of buildings our ancestors would have used.
By E.T.Lewis,printed by E.L.Jones, Cardigan 1969. We found this little hard-back book in a car-boot sale recently. It must have been published by the author after much research into the locality of this small settlement at the foot of the Preseli Hills in Pembrokeshire. It would be a useful little book for anyone with roots in the parish for,as the subtitle suggests, it gives a survey of the area from the Middle Ages up to the 20th century. There are names of people and farms from 16th and 17th century records held in the PRO, extracts from diaries, parish, nonconformistsrecords, vestry books, censuses and electoral rolls. In the lists of headteachers of Mynachlogddu school there is the name of the father of one of Wales greatest poets, Waldo Williams, who spent many of his formative early years living here and who is commemorated with the simple stone on Rhosfach that looks up and across his "Mur fy mebyd" (wall of my childhood).In addition to a map and black and white photographs there is a chapter devoted to biographical details of 19th and 20th century people born in, or associated with, Mynachlogddu.There are interesting appendices listing chapels,wells, buildings, names of people and places, a map code and bibliography.
By Bethan Phillips, published by Cymdeithas Lyfrau Ceredigion 1997. This is the well-researched history of a real "baddy" and the accursed mansion of Peterwell, also called Ffynnonbedr, that is but a pile of stones today just outside Lampeter. Sir Herbert Lloyd (1720-1769) was the last, and the worst, of the Lloyd family; a man born to destruction, greedy, cruel and vindictive. It is a fascinating study and a really good read. Useful to the family historian with ancestors from the Lampeter area and even further afield, there is a comprehensive index of persons and places that are referred to in the book. I found that the appendices contained much of interest, including accounts relating to Sir Herbert Lloyd, medical records of John Lloyd, rental records of the estate, an inventory of effects put up for sale in 1781, extracts from Lampeter parish records and a detailed bibliography. There are many black and white illustrations of various well-known people such as Lewis Morris and Howell Harries and mansions like Gogerddan and Dolaucothi as well as contemporary pictures of cock-fighting, a hanging, the medieval church at Lampeter that was demolished in 1821. There is a map showing the location of the ruins of Peterwell and a photograph of the avenue of trees that still exists today so you can go and see the site and setting of this excellent book.
By David N. Thomas, published by Seren, the book imprint of Poetry Wales Press, Bridgend, 2000 ISBN: 1-85411-275-9.
Yet another book on Dylan, you sigh, cry, moan! But this has tied in with my family history and may do for many others who have roots in deepest West Wales. This is a fascinating, very well-researched book which deals with Dylan's many links with Cardiganshire and his relationship with local people and refers to people and places that previous biographers have missed. David Thomas, who lives in Ciliau Aeron, has spoken to people in West Wales who had met Dylan and there are numerous photos which have come to light and might include your family on them. A friend of mine, living at Newquay, looked through the book and found, to her astonishment, a hitherto unknown photo with her mother, born in 1900, on it. I looked in the index and found several references to various family members and also a drawing of Dylan done by a relative of mine, Myra Evans, who was born back in 1883. There are fourteen pages full of names of people and places in the very comprehensive index. In the appendices there are references to books and articles used in the research, names of people interviewed and sources of information and even some family tree information on certain West Wales people associated with Dylan. The area covered is around Talsarn, Talgarreg, Llanon, Aberaeron,Llanina, New Quay and Llangrannog.
By J. Geraint Jenkins, published by Gomer Press in 1982.
There is an online index and review to this book on INDEX
In the series "Britain in Old Photographs".
There is an online index and review to this book on INDEX
- 28 . The Welsh House
by Iorwerth C. Peate
First published in 1940, reprinted by Llanerch Publishers, Felinfach in 2000. ISBN 1 86143 112 0.
Here is an online review and listing of the Contents, Illustrations, Figures and houses and sites mentioned in the 1940 book INDEX
Editor Caroline Charles Jones, Published by Brawdy Books 2000, ISBN 0 9528 344 48
What a mine of information for the family and local historian! A real treasure chest for anyone with Cardiganshire ancestry. We in West Wales owe a great debt to Francis Jones,1908-1993, late Wales Herald at Arms who was one of the most distinguished Welsh historians, for his many years of tireless research into Welsh history, genealogy and heraldry.
This hardback well-bound book, has 332 pages, illustrated with line drawings and photographs. The Cardiganshire houses are listed alphabetically with a history of each house and families who resided or had connections with it, with full references for further research. The extensive bibliography describes printed primary and secondary sources and also lists the primary sources of manuscripts, private collections,journals, periodicals and various other information consulted at various record offices and libraries. An index of names links people with the various houses mentioned in the text.There is a map of the Cardiganshire Tithe districts and, inside the front and back covers, a reproduction of Speed's 1630 map of Cardiganshire.
Congratulations to Hugh and Caroline Charles-Jones on publishing this invaluable book for us family and local historians.
Details of this and the other books published so far can be found on Brawdy Books websites:
www.brawdybooks.com or www.westwalesgenealogy.co.uk
e-mail addresses: email@example.com or firstname.lastname@example.com
Telephone/Fax: 01348 811450
Postal address: Brawdy Books, Plas yr Wregin, Dinas, Newport,Pembrokeshire, SA42 0YH
An online review and index compiled by Mary Jane Stephenson is available on INDEX
Mary Jane Stephenson
Also comes as a Pocket Guide by J Graham Jones published by University of Wales Press (1990). It has a list of useful dates.
Mike Thomas
By W.L.Davies ISBN 0 905243 15 3
Published by the Glamorgan Record Office & M.T.Heritage Trust
A bridge is a convenient device for crossing an obstacle. Where there are many natural and manmade obstacles and a need to move people and materials, there will be many bridges. This was true of Merthyr in its precocious industrial development in the eighteenth and nineteenth centuries.
All told there are more than 300 bridges in the Merthyr Tydfil area, and they have been identified, catalogued and researched by `Leo' Davies for the present volume. More than 300 photographs, works of art and maps are reproduced, many of them hitherto unknown to the public. Merthyr Tydfil was a testing ground for bridge-building techmques, as the iron companies vied with each other the improving transport and communications within their works and with the outside world. The iron industry has vanished from Merthyr Tydfil, with many of the bridges which served it. Now bridges for other purposes are needed, as on the Heads of the Valleys road and the Merthyr trunk road. The on-going story is told in this book, as well as that of the old pioneering days.
This book will interest many different kinds of reader, the local patriot, wanting to know about the achievements of the past, the industrial archaeologist, seeking technical descriptions for comparison in similar investigations elsewhere, and the social historian, trying to assess the effect of technical changes on the life of the people.
Alun Jones
A collection of essays by Dr Tom Davies.
Published in 2000 by W Glamorgan Archives Service.The cost of the book is £17.50 plus £4 p&p[UK]. It is available from the Archive Service at County Hall, Swansea, Neath Library, and Port Talbot Library. Limited Edition of 800.
The original index has been extracted with the publisher's permission and is on INDEX
Includes chapter headings :
Civic Life in Neath
Chap 1 : Neath`s Wicked World- some episodes in legal history
Chap 2 : The state of Neath and district in 1880 according to the "Neath Times"
Chap 3 : Mr D. Rhys Phillips
Chap 4 : Whatever happened to :
- - the Reverend David Davis of Neath
- -John Edwards of Rheola
- -Richard Worthington of Gellidorchleithe, Creunant
- -Herbert Edward Evans of Eaglesbush, Neath
- -Joshua Williams of Aberdulais
Chap 5 : Dulais Uchaf and two of its nineteenth century diarists
Landed Estates
Chap 6 : The Aberpergwm Idea : Maria Jane Williams`s brothers
Chap 7 : Ynysygerwn, Aberdulais
Brian Wagstaffe
- The Customs and Traditions of Wales [ a Pocket Guide]
By Trefor M. Owen. University of Wales Press/Western Mail 1991 . ISBN 0-7083-1118-8
From the back cover;
"This concise and informative guide looks back to the customs and traditions of a predominately rural Wales during the C19--the revelries of the corn harvest; winter nights by the fireside, knitting, telling stories and making rush candles; overcoming poverty and hardship by raising funds at a cwrw bach.........Each chapter is complemented by several eye-witness accounts--vivid descriptions of a forgotten way of life. Customs are arranged into four main groups ; those centred on the hearth and home, agriculture, community life and the parish church.
Trefor M Owen, former Curator at the Welsh Folk Museum, is a recognised authority on Welsh folk traditions. In this book he explores their origins and examines the changes they underwent during the C19 and early C20 in response to industrialization and the growth of Nonconformity."
- 1)Working the Land
- 2)Customs of Hearth and Home
- 3)Community Traditions
- 4)Church Festivals and Practices
- 5)Changing Traditions
- 6)Studying Folk Customs
- Selected Reading list
Mary Hamilton
Norman L Thomas. Gomer Press. 1978. 245 Pages, ISBN 0 906199 026
An online index compiled by Eluned Lloyd is available on INDEX
Chapter headings:
- 1 Ancient and Modern
- 2 Twentieth Century Developments
- 3 The Mumbles railway
- 4 The Limestone Industry
- 5 The Oyster Fishery
- 6 Water Supplies and Aspects of Public Health
- 7 Oystermouth Castle
- 8 Topographical Descriptions of Yesteryear
- 9 Rescue at Sea and Protection of the Coastline
Illustrations: All B&W
- 31-38
- Seylers Gower Manorial System (drawing) No date
- Mumbles Circa 1869 (photograph)
- Town Hall, Somerset Place, Swansea (photograph) No date ?1900ish
- Mumbles 1888 (painting, Hannaford)
- Oystermouth 1892 (photograph)
- William Goddard Circa 1890 (DG Bowden,)
- 106-116
- The Dunns 1906 (postcard) DG Bowden
- Mumbles Cabbies' Fishing Club 1909 (photograph)
- The Dunns 5 June 1922 (photograph)
- Mumbles Circa 1922 (photograph)
- Newton Road Circa 1920s (photograph Rowley Davies)
- Gower map (illustration)
- 0-6-0 Tank locomotive (drawing)
- 106 seat BTH electric car 1929-1960 (drawing)
- Horse drawn Mumbles Train Circa Mid-1860s (photograph)
- Edwardian Days (photograph)
- Mumbles Train 19 July 1920 (photograph)
- Mumbles Train 1950s (photograph)
- Mumbles Train at Southend 1959 (artistic impression)
- Edwardian Advertisment for mumbles Railway Co (facsimile)
- Mumbles Railway Anniversary 1954 (photograph)
- The Mumbles Railway (Cheltenham) Badge (no date)
- 134
- View from Norton Limeworks Quarry 1925 (photograph)
- 155-162
- Mumbles Oyster Vessel 1875 (photograph)
- Mumbles Oyster Vessels Circa 1875 (photograph)
- Circa 1880s and prior to the loss of the skiffs' lay-up enclosed by the Mumbles Railway embankment of 1893 (photograph)
- Mumbles 1888 (painting)
- Era prior to the Mumbles embankment 1893. (photograph)
- Mumbles Railway Embankment 1893 (photograph)
- Skiff details (drawings)
- Swansea Bay and Mumbles area Oyster Beds 1949 (sketch)
- 198-200
- Oystermouth Castle (photograph) (no date)
- Oystermouth Castle circa 1910 (photograph)
- All Saints Oystermouth Parish Church circa 1850s (photograph)
- 215-226
- Mumbles Lighthouse Battery Navel Gun circa 1860s at Swansea Marina 1978 (photograph)
- Caswell Bay early 19 C print
- New three storey houses in Newton Road 1872 (photograph)
- Edwardian days (pier) (photograph)
- Pre-Edwardian days (Bandstand) (photograph)
- Pier-Edwardian Days
- The Parade circa 1906 (Postcard)
- Oystermouth Square 1920s (photograph)
- The Dunns 1920s (photographs)
- Opening of the Wales Tourist Office Oystermouth May 1977 (photograph)
- The Gower Pony with Newton WI Members 1977 (photograph)
- Mumbles View 1962 (painting BV Parkyn)
- 246-247
- Stained Glass window All Saints Oystermouth 1977 (photograph)
- Presentation to Mumbles Lifeboat 1977 by Mumbles Round Table (photograph)
From book jacket:
'From it's inception as the Oystermouth Manor of the Lordship of Gower onwards, the mumbles story here has been traced to modern times and embraces historical events , the rise and decline of former industies, the influence of religious denominations, religious changes and maritime affairs. The history of the Mumbles railway, Chapter Three, should prove of added interest. Research into many sources has helped to produce a fascinating account of a small fishing village which was once famous for the quality of its oysters in centuries past. Later, Mumbles became an Urban District Council of the late 19th C. and early part of the present century when it was absorbed afterwards by the Swansea County Borough's extension programme of 1918. Its status today is that of a bustling Ward and an immensely popular seaside resort of the 1970's within the Swansea City scene.'
Eluned Lloyd
- 1. The Carmarthen Antiquary. VOLUME 2 , PARTS 1 & 2 , 1945 & 1946
The Transactions of the Carmarthenshire Antiquarian Society and Field Club
(Trafodion Cymdeithas Efrydu Hynafiaeth a Natur yn Sir Gaerfyrddin)
- By Dr. H. N. Savory, F.S.A.
- A perforated stone axe-hammer (fig.1) was found by Mr. Morgan Williams of Hafod Farm, Ffairfach, Llandeilo, in the bed of the Afon Cib, a small stream which rises close to Hafod Farm.
- The second implement, a looped palstave (fig.2), was found in 1944 by a farm-servant lying outside the entrance to a rabbit burrow on Cilsan-uchaf Farm, Llangathen.
- By T. H. Lewis, M.A.
- The family history of the DuBuisson's at The Glynhir Estate 1770 - 1921.
- Including 'The Genealogical Table of The Du Buisson Family'
- Gan Gomer M. Roberts.
- By T. H. Lewis, M.A., H.M.I.
- 1. The Cil-yr-ychen Lime Firm Ledger Book.
- 2. A Caerbryn Colliery Account Book.
- By J. F. Jones, B.Sc.; Cefni Barnett ; Eirwen Jones, B.A.
- A GROOVED HAMMER FROM RHANDIRMWYN, CARMARTHENSHIRE. Arch. Camb., 1934, 339-40.
- NEW EARTHWORK. J. F. Jones.
- ROMAN COINS FOUND IN CARMARTHEN. Cefni Barnett.
- TWO CORRECTIONS. J. F. Jones.
- LAUGHARNE RING-BROOCHES. J. F. Jones.
- VICARS OF MYDDFAI, 1673 - 1948. J. F. Jones.
- CARMARTHEN STYLUS. J. F. Jones.
- A WELSH WIZARD. Eirwen Jones.
- By Cefni Barnett.
- CORPUS INSCRIPTONIUM INSULARUM CELTICARUM, VOLUME I. R. A. S. Macalister.
Edited by E. VERNON JONES
VOLUME XI , 1974. Cover price 30p.
Published by: Carmarthen Community Council (V. G. Lodwick & Sons Ltd., Carmarthen)
Being the Journal of its Local History Committee, Dark Gate Chambers, Red Street, Carmarthen
By Major Francis Jones, C.V.O., T.D., D.L.Welsh Herald of Arms Extraordinary
Taken from four journals (1865 - 1872) written by Agnes Hermione Jennings of Gellideg, preserved in the Carmarthenshire Records Office.
- (a) Ancestry 3 - 11
- (b) The Author of the Journals 11 - 13
- (c) The Journals 13 - 15
The Journal 1865 16 - 24
- Our excursion to Tenby 16 - 18
- Archery Meeting at Llandeilo 16 - 18
- Our visit to Plas, Llanstephan 18 - 19
- Our visit to Fynone, Pembrokshire 19 - 22
- Our visit to Dirwen, Glamorganshire 22 - 24
The Journal 1866 24 - 54
- 23rd January 24
- Hunt Ball at Carmarthen, Tuesday, February 6 1866 24 - 26
- The Second Hunt Ball, Tuesday, February 8, 1866 26 - 27
- Our visit to Pentre 27 - 30
The London Season
- Dinner Party given by Mrs Stavely at the Grosvenor Hotel, London 30
- The Queen's Court held at Buckingham Palace on Friday the 23rd of March 30 - 32
- The Haymarket Theatre 32
- Dinner at Lady Belcher's 32
- Evening Party given by Mrs Derby Griffiths 32
- At the Princess Theatre 32
- Madame Pazzi's Concert 33
- Opera of "Marta" at Her Majesty's Theatre 33
- Concert at the Crystal Palace, Performance of Handel's Acis & Galatea 34
- Gallery of Illustrations. Mr and Mrs German Reed and Mr John Parry 34
- The Yorkshire Ball at Willis's Rooms 34
- Mrs. Weston's Concert 35
- General Hamilton's Dinner Party 35
- Mrs. Lewis Loyd's concert, 20 Hyde Park Gardens 35
- Mrs. Bentley's Dinner 35
- The Royal Academy 36
- Our first dinner party 36
- Our second dinner 36
- Sir James Hamilton's dinner 36
- Mrs Alfred Douglas Hamilton's small evening party 36 - 37
- Mrs Dyce Nicoll's ball 37
- The Fourth of June 37 - 38
- Mr Pulsford's Dinner Party 38
- Miss Rawson's dinner 38
- Mrs Foster's ball 38
- Our ball 38 - 39
- The Princess's Theatre 39
- Lady Anson's Assembly 39
- The Champagne's Dinner 39 - 40
- Mrs Barnet's evening party 40
- Mrs Weston's Matinee 40
- Mrs Reynolds' ball 40
- Mrs. Phillips' ball 40
- Mrs Albert Goldsmid's Ball 40 - 41
- Mrs Gwinne Holford's Concert 41
- Mrs. Coverdale's Croquet party 41
- Mrs Hopkinson's Ball 42
- Mrs Cock's Ball 42
- Mrs Orme's Ball 42
- Mr Mackinnon's Ball 42
- Mrs A. Hamilton's Party. Music and Dancing 43
- The Bulwer's drum 43
- Sir Claude Scott's Ball 43
- Mrs. Dent's Ball 43
- Amount of Gaiety in 1866 44
- The Bulwer's dinner Party 44
- Aunt Louisa's dinner and evening party 44
Back in Wales
- Visit to the Gulstons 44 - 46
- Croquet Party and Dance at Aberglasney and visit to Dirleton 46 - 48
- Third visit to Direlton 48 - 49
- Dinner party at the Crosses [Iscoed] 49
- Luncheon Party at the Prices [Oaklands] 50
- Dinner Party at Mrs H. Williams [Edwinsford] 50
- 2nd Dinner Party at Mrs. H. Williams 50
- Fourth visit to Dirleton for the Archery Meeting 50 - 52
- Third dinner party at Mrs Hamlyn Williams 52
- Fourth dinner at Mrs H. Williams's 53
- Our magic lantern party 53
- Our visit to Mrs Biddulph 53 - 54
By T.L.Evans, B.A.
- Introduction 55 - 56
- Many Navvies, Little Trouble 56 - 57
- Ganymede, Pearl and Caliban 57 - 58
- First Accident 58 - 60
- Disorderly Passengers 60 - 61
- Bridge Destroyed 61 - 62
- Postscript 62
By D.L. Baker-Jones, J.P., M.A. 63 - 67
- William Basil Jones, Bishop of St Davids.
Son of the squire of Gwynfryn, North Ceredigion.A POET UNEARTHED 68
By D.C.Jenkins 68 - 70
- Thomas Jenkins of Llandilo & Carmarthen
No author supplied 71 - 74
- Hugh Williams of Gardd, St Clears
No author supplied 75 - 76
- M.H.Jones 1873-1930
By H.J.Lloyd-Johnes, O.B.E. 77 - 79
- Dolaucothi, Cayo, Cothi Valley, Carmarthenshire.
- 'Not so inept'
- By Gomer M. Roberts, Brynawel, Llandybie 79 - 80
- Re: Note on John Jones, Derwydd, Llandybie (Vol. Viii, 1971, pp. 77 - 78)
- 'Interesting Maniac'
- By H.Lloyd Jones, Fosse Hill, Coates, Cirencester 80 - 81
- Re: Murder of William Powell, Glanareth, Llangadock in 1770 (8th January)
By D.C.Jenkins, Carlyon Bay, St. Austelles.
- A Carmarthenshire Settler in Cornwall.
By E.V.J.
- Tribute to Major Francis Jones.
Katy Jenkins


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Robbing Peter, the debut feature from writer/director Mario F. de la Vega, tells three stories of crime and betrayal across the U.S.-Mexican border which intertwine toward a climactic finish. Unable to find work as a mechanic, Pedro (Louie Olivo Jr.) scores a job from local crime boss Don Epifiano (Victor Martinez) -- or rather, from the eccentric drug lord's pet rabbit, Fluffy. Fluffy orders Pedro to accompany a gringo pilot named Paul (Joe Keyes) on a drug deal into Arizona, but Pedro misses his...more
All Robbing Peter cast + crew photos


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BRUSSELS — Google Inc. clinched a landmark settlement in its high-profile case with European Union antitrust regulators to address concerns that it is abusing its dominance in online search.
Under the deal, reached on Wednesday after weeks of last-ditch negotiations, Google GOOG, -0.39% has agreed to give comparable prominence in online search results to services offered by three rivals.
Future of Google Smartphone Search? Normal Speech
When it comes to searches on your smartphone, Google hopes you can eventually say goodbye to typing and hello to talking. Google's Tamar Yehoshua shows WSJ's Deborah Kan what's possible right now.
The deal is the culmination of a protracted, roller-coaster probe opened more than three years ago that has seen earlier two earlier hopes of a settlement collapse, and the Internet giant in turn praised and admonished by the EU's antitrust chief, Joaquín Almunia.
The European Commission said Google had now agreed to guarantee that whenever it promotes its own specialized services and products, such as for hotels, restaurants or shopping, the services of three rivals would be displayed clearly and in a way that is "comparable" to how Google displays its own services.
That offers comes on the back of two earlier rounds of proposals, when dozens of competitors such as Microsoft Corp. MSFT, +0.17% Expedia.com EXPE, +0.57% and Finnish handset maker Nokia Corp. NOK, -0.19% noisily rebuffed proposals by Google to more prominently display its rivals' services in shaded boxes in online searches.
An expanded version of this report appears on WSJ.com
More must-reads from MarketWatch:
Microsoft 'safe choice' Nadella may surprise


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Penname: | Jellybeansxox | Member Since: | 2010.07.15 |
Track This Author: | |
Stories Posted: | 1 |
Reviews Posted: | 15 |
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|< 1>|
: You'd be on My Pro List by Jellybeansxox
Novel Meril Lizlow is known for getting into trouble, which is exactly what gets her sent off to Wizarding Boot Camp for two years. Now, she's back, but things have changed while she's been away. Follow Meril as she gets herself into trouble, fights, and hilarious situations; as she struggles with her emotions and tries to untangle herself from the web she's caught herself in-a web of lies she's told herself; a messy web of love. Genres: Humor, Romance, Young Adult Era: Hogwarts Characters: Fred, George, OC, Oliver, OtherCanon Pairings: Other Pairing Advisory: Mild Language, Mild Violence Published: 2010.07.15 Latest Chapter: 2010.07.19 Updated: 2010.07.19 Status: WIP (2634 words) |


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Supreme Court
The Supreme Court of Yukon is the highest trial court in the territory, with broad jurisdiction to try a wide range of civil and serious criminal matters. The Supreme Court has exclusive jurisdiction to hold jury trials and murder cases. It also hears appeals from certain criminal trials and regulatory matters, known as summary conviction appeals. The Supreme Court also acts as an appeal court for various statutory tribunals and can, in certain circumstances, judicially review the decisions of administrative tribunals. In family matters, the Supreme Court of Yukon has authority to make custody and support orders, to divide matrimonial property, and to grant divorces.
The Court is currently made up of two resident judges, the Senior Judge, Mr. Justice Ronald S. Veale and Mr. Justice Leigh F. Gower. The Court is also composed of nine judges from the Northwest Territories and Nunavut and 44 deputy judges appointed from across Canada. A deputy judge or a judge from another northern territory may be called upon from time to time where conflicts of interest arise with the resident judges or to resolve scheduling problems.
Upon appointment, the Judges of the Supreme Court of Yukon are also ex officio members of the Court of Appeal for Yukon, the Northwest Territories Court of Appeal and the Nunavut Court of Appeal and can be called upon to act as appellate judges in any of those courts.
The Supreme Court sits regularly in Whitehorse and in other Yukon communities, as required. It is generally open to the public. Access to certain files, such as family law matters, may be restricted by court policy.
The Rules of Court were effective September 15, 2008, and govern all proceedings whenever commenced. The Court also issues practice directions from time to time on matters of procedure and court conduct.


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The Best Bet
Accessories are the understudies-become-stars of the current fashion season—an excellent turn of events for Tony Duquette, whose jewelry is just as exuberant as the Hollywood sets, interiors, furniture, and costumes he designed for five decades. Although he died in 1999 at 85, his business partner of three decades, Hutton Wilkinson, still makes pieces with the Duquette name and spirit. This bib-style necklace contains 62 Baroque South Sea pearls and 29 carats' worth of diamonds, set in eighteen-karat white gold. It and other one-of-a-kind pieces are exclusively at Bergdorf Goodman. Warning: One-of-a-kind does not come cheap ($227,675; 754 Fifth Ave., nr. 57th St.; 212-753-7300).


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Collections are a JPG+ feature. You must be a JPG+ member to create new collections and to add photos to collections.
Sign up for JPG+ to start using collections now!
Photo license: © All rights reserved
The bridge shown here spans what was originally the Molonglo River, dammed to build Lake Burley Griffin, the water centrepiece of the federal Australian capital city, Canberra, in the original plans of Walter Burley Griffin. This is a view from the north side, where the city's civic centre sits, and stretches across to the 'parliamentary triangle', which includes the federal house of parliament.
I have lived in Canberra three times - from 2002 to 2007, again in 2009, and in 2012 - I think I have a bit of a love/hate relationship with the place, it pushes and pulls and I am never really sure why.
In the Places in My Heart photo essay.
No responses
Also by Tom Harvey


text:
The TL8 series devices employ a high-volumetrically efficient packaging solution to enable the industry's highest capacitance-voltage ratings in small case sizes down to 0805 with low profiles from 0.8 to 1.0mm. Vishay Sprague TL8 capacitors are offered in a variety of compact EIA standard footprints, including the 0805 (2.0x1.25mm), A case (3.2x1.60mm), and B case (3.50x2.80mm). The devices come with standard capacitance tolerances of ± 10 % and ± 20 %, and an operating temperature range of - 55 to + 85°C, or + 125°C with voltage derating.
With their small case sizes and low profiles, the TL8 capacitors save board space for bulk capacitance, energy storage, filtering, and decoupling in the next generation of ultra-thin smartphones and other handheld, battery-operated consumer electronics. In addition, the devices' high voltage ratings are ideal for OLED displays. The capacitors' lead (Pb)-free, L-shaped facedown terminations offer better mechanical and electrical contact to the solder pad than traditional facedown-style terminations. The RoHS-compliant devices conform to Vishay's "Green" standards and are available in 8 mm tape and reel packaging per EIA-481.
Visit Vishay Intertechnology at www.vishay.com


text: ©1995- Strict Standards: date(): It is not safe to rely on the system's timezone settings. You are *required* to use the date.timezone setting or the date_default_timezone_set() function. In case you used any of those methods and you are still getting this warning, you most likely misspelled the timezone identifier. We selected 'America/New_York' for 'EDT/-4.0/DST' instead in /homepages/34/d198773891/htdocs/base_amila/amila_footer2.txt on line 1 2017 American Muslims Intent on Learning and Activism. All rights reserved. Contact AMILA for more information. |


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Amitava Sur
Love You Dear - Poem by Amitava Sur
She never said, uttered a word.
And she never did cry.
She only looked at me
With her wide open eyes.
Eagerly when I took her palm
To convey my love and to embrace,
It was so chilled like ice -
And she was silent and numb.
I only could read the tragic pains in them
In those dry patches of tears, down her cheeks,
They spoke about her parting pain-
Until time allowed them to drip.
Still she left a smile on her lips
As a reminiscent of her love for me,
Kept her fingers still stretched out
For holding me finally with love.
Love you dear, with an ever lasting love
Wherever your abode is.
Amitava (25.04.2014) 4-00 pm
Topic(s) of this poem: love
Poet's Notes about The Poem
Comments about Love You Dear by Amitava Sur
Tanya Gupta (4/25/2014 9:20:00 AM)
its so beautifull. the love shown is so pure and unique.
great job.
thanks! (Report) Reply -
Roseann Shawiak (4/25/2014 8:59:00 AM)
Absolutely beautiful, Amitava. Your love for one another goes beyond imagining.
Such a totally poignant poem, heart-wrenching, but gentle with your love for her.
I love this one too, Amitava! (Report) Reply
Read this poem in other languages
This poem has not been translated into any other language yet.
Amitava Sur's Other Poems
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Maya Angelou
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If You Forget Me
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Caged Bird
Maya Angelou
Rudyard Kipling
Stopping By Woods On A Snowy Evening
Robert Frost
A Dream Within A Dream
Edgar Allan Poe


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I never would have guessed... it would go by this quickly. I know, yadda yadda, so cliche, but it is going by so fast. Alice is almost 4 months. Gasp! I got her to giggle for the first time yesterday. We were dancing in front of the mirror, and there it was, a little chuckle. I nearly died. My heart exploded. (My heart seems to have a fast recovery time considering how many times it's exploded in the last 4 months.)
I never would have guessed... I'd spend so much time thinking about Alice's sleep. On any given day I have no idea when she'll sleep or for how long. I can tell you that she'll likely take four naps, but when they occur and how long they last is only known by some little sleep center in Alice's brain. Right now she is taking a long nap, almost an hour and a half, which is lovely and amazing, for me and her. You see, Alice's sleep and the blog are deeply connected, because when she naps I can blog. So along with sleep I'd say I never would have guessed it would be this hard to blog. I miss it. I crave it. And yet, it's still hard to get to.
I never would have guessed...that homemade challah would be this good. Ever since Darcy posted the recipe I have been dying to make it. There's something about making your own bread that is incredibly satisfying. It's easy, yet it feels like such a worthwhile accomplishment. I've been delighting in buttered toast and avocado sandwiches and dreaming of French toast and bread pudding.
.... and here are a few favorites from my iphone.....
1) Alice all bundled for an excursion outside
2) yes, my baby has a bald spot - will it ever grow back?
3) my little Who from Whoville - reading Dr. Seuss, Horton Hears a Who
4) a nice evening stroll
5) Alice and I rode the Chocolate Tram around town. She was eyeing all the treats.
6) cozy in her sleep sack
7 ) Fall! I love Fall!
8) Alice busy playing with her toy gym.
...and the little lady is still sleeping - from start to finish in one nap time - it's a blogging miracle :)


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She thought she was straight, but she's fallen deeply in love with a woman. What now?
Send your questions to firstname.lastname@example.com, and remember to include a nickname if you don't want to be identified.
I have fallen in love with someone who I feel I should not have. We have known each other now for almost six months and having them in my life has been amazing, and I can say this from both our sides. The respect, love, adoration and communication is just amazing. I have never felt so connected with anyone before.
The only issue is we are both females. I have never been with a woman and neither has she. She is twice my age, has kids and is separated. I have only ever dated men and have never been interested in women in my entire life, so all these feelings are completely new.
Whenever we have a few drinks we always get so close it feels like we are going to kiss, but we never do. We kiss on the cheek lots, we spoon when we stay together, we talk on the phone and text all the time, so this makes it even harder sometimes because I can't stop thinking about her.
She is just so beautiful, smart, funny, intelligent, she makes me think every day. and when I look in to her eyes., it is like my heart melts.
What do I do? I love her so much and we have both said these words to each other. The awful thing is I know in our heads we both think that we are straight. What do we do?
What a surprise for you! In terms of the relationship all is going wonderfully well, the constraints appear to be around your idea of yourself, and perhaps what this might mean socially should you enter into a same-sex relationship more fully. Is this correct?
Firstly, the issue of sexual identity. You are both in a position to be able explore the relationship, and you feel a strong affinity with one another. I hear that this challenges your heterosexual identity, and poses you with a possibility you haven't considered before.
When we think about sexuality, we can do so in terms of four continuums, sexual orientation (what we are attracted to), sexual identity (how we view ourselves), social identity (how others see us), and sexual behaviour (what we do). We can move up and down on these continuums at different times of our lives, much more than many people realise. You have experienced a new shift in your orientation (you find yourself attracted to a woman), this is somewhat confusing for you (your identity) even while you start to explore some forms of physical intimacy with this woman (your behaviour). We can experience internal conflict when these ducks don't all line up.
Just a little flag for me, but equally important as the issue of sexual identity is the age difference that you describe. There is not enough detail to know here, but if for example you were say 22 and your friend is 46 there is likely to be a significant power differential in the relationship. You may have some challenging conversations ahead around the different wants and needs you have in different life stages, and how you see your futures. You may want to
give some consideration to this area and what it means to you both.
What to do? In terms of exploring this same-sex attraction you have already started to act on it, and a big question is how willing are you to explore this further. Can you be open to the feelings that you have, and the new meanings that might come from them? Even though it may initially be confusing, are you open to broadening your idea of who you are? To what degree would this exploration brush up against your own attitudes around sexual orientation,
or those of others? Do you have the strength to confront these and explore a new identity?
If you are interested in this exploration it will be important to keep talking with your friend about what it means for you both. The more you can be real and open with each other around how you are feeling, the better. Give yourself room to move and explore without coming to hard and fast rules and decisions. Let the answers come with time and with conscious exploration. Remember to look after your "self" in any exploration, until you are willing to
declare any new found identity publicly.
Know the friends and family who you can trust and get support from, and those who will muddy the waters with their own agendas. Keep reaching out for help when you need it. I wish you the best with this new journey,
For more advice and information on counselling, visit Relationships Aotearoa online or join them on Facebook.
We'd love to hear your take on this week's issue. Before you comment below, though, remember that this is a real-life situation. This reader has bravely shared their personal life with you; please show them respect by refraining from hurtful or abusive comments.
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Do traditional school rules still have a place in modern New Zealand?


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Photo Gallery: The Ship-Breakers of South Asia
With the global shipping industry still suffering as a result of the weak world economy, ship scrapping businesses, most of which are located in South Asia, are experiencing a boom. But a lack of environmental and safety standards, combined with low pay for the workers, make it a dangerous undertaking. Here, Alang shipyard in India.


text:
The Western Right
Defending Western Civilization from Western Michigan University
Sunday, January 06, 2013
Ban Schools?
Two recent articles offer a different solution to school shootings.
Ban Public Schools, Not Guns.
Ban Schools, Not Guns
School shootings are pretty rare, so they are not a reason to do this. But the articles give plenty of other reasons.
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text:
Butternut Squash Layer Cake Recipe
The recipe for this lovely tall cake with its yummy old-fashioned frosting has been in our family for as long as I can remember.
- 1/2 cup butter, softened
- 1 cup sugar
- 1 cup packed brown sugar
- 2 eggs
- 1 cup mashed cooked butternut squash
- 1 teaspoon maple flavoring
- 3 cups cake flour
- 4 teaspoons baking powder
- 1/4 teaspoon baking soda
- 1/2 cup milk
- 1 cup chopped walnuts
- 1-1/2 cups packed brown sugar
- 3 eggs whites
- 6 tablespoons water
- 1/4 teaspoon cream of tartar
- 1/8 teaspoon salt
- 1 teaspoon vanilla extract
- 1. In a large bowl, cream butter and sugars until light and fluffy. Add eggs, one at a time, beating well after each addition. Beat in squash and maple flavoring. Combine the flour, baking powder and baking soda; add to creamed mixture alternately with milk. Stir in walnuts. Pour into two greased and floured 9-in. round baking pans.
- 2. Bake at 350° for 25-30 minutes or until a toothpick inserted near the center comes out clean. Cool 10 minutes before removing from pans to wire racks.
- 3. For frosting, in a heavy saucepan, combine the brown sugar, egg whites, water, cream of tartar and salt. With a portable mixer, beat on low speed for 1 minute. Continue beating over low heat until a thermometer reads 160°, about 8-10 minutes.
- 4. Pour into the bowl of a heavy-duty stand mixer; add vanilla. Beat on high speed until stiff peaks form, about 3 minutes. Spread between layers and over top and sides of cake. Yield: 10-12 servings.
Nutritional Facts
1 slice: 524 calories, 15g fat (6g saturated fat), 57mg cholesterol, 310mg sodium, 92g carbohydrate (63g sugars, 2g fiber), 8g protein.
Reviews for Butternut Squash Layer Cake
Reviewed Apr. 18, 2011
"This recipe is a copy of one already on the internet and located at:
http://www.yummly.com/recipe/Butternut-Squash-Layer-cake.It is almost verbatim.I suggest that if you wish to offer a recipe to be published, it should be your own and not one copied off of the internet.I did make the cake and, by the way, it was delicious.A lot of calories though due to all of the sugar used."© 2017 RDA Enthusiast Brands, LLC


text:
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text:
Calcium and Vitamin D increase mRNA levels for the growth control hIK1 channel in human epidermal keratinocytes but functional channels are not observed
© Manaves et al; licensee BioMed Central Ltd. 2004
Received: 23 February 2004
Accepted: 16 June 2004
Published: 16 June 2004
Intermediate-conductance, calcium-activated potassium channels (IKs) modulate proliferation and differentiation in mesodermal cells by enhancing calcium influx, and they contribute to the physiology of fluid movement in certain epithelia. Previous reports suggest that IK channels stimulate proliferative growth in a keratinocyte cell line; however, because these channels indirectly promote calcium influx, a critically unique component of the keratinocyte differentiation program, an alternative hypothesis is that they would be anti-proliferative and pro-differentiating. This study addresses these hypotheses.
Real-time PCR, patch clamp electrophysiology, and proliferation assays were used to determine if human IK1 (hIK1) expression and function are correlated with either proliferation or differentiation in cultured human skin epidermal keratinocytes, and skin biopsies grown in explant culture.
hIK1 mRNA expression in human keratinocytes and skin was increased in response to anti-proliferative/pro-differentiating stimuli (elevated calcium and Vitamin D). Correspondingly, the hIK1 agonist 1-EBIO inhibited keratinocyte proliferation suggesting that the channel could be anti-proliferative and pro-differentiating. However, this proliferative inhibition by 1-EBIO was not reversed by a panel of hIK1 blockers, calling into question the mechanism of 1-EBIO action. Subsequent patch clamp electrophysiological analysis failed to detect hIK1 channel currents in keratinocytes, even those expressing substantial hIK1 mRNA in response to calcium and Vitamin D induced differentiation. Identical electrophysiological recording conditions were then used to observe robust IK1 currents in fibroblasts which express IK1 mRNA levels comparable to those of keratinocytes. Thus, the absence of observable hIK1 currents in keratinocytes was not a function of the electrophysiological techniques.
Human keratinocyte differentiation is stimulated by calcium mobilization and influx, and differentiation stimuli coordinately upregulate mRNA levels of the calcium-activated hIK1 channel. This upregulation is paradoxical in that functional hIK1 channels are not observed in cultured keratinocytes. It appears, therefore, that hIK1 does not contribute to the functional electrophysiology of primary human keratinocytes, nor intact human skin. Further, the results indicate caution is required when interpreting experiments utilizing pharmacological hIK1 modulators in human keratinocytes.
Intermediate conductance, calcium-activated potassium channels (IKs) stimulate proliferative growth in T-cells and fibroblasts [1, 2], via their ability to maintain a negative membrane potential, thus enhancing the electromotive driving force for calcium entry [3], a mitogenic requirement in these cells. IKs have also been suggested to modulate secretion and cell volume in epithelial cells from the gut and airways [4–7], but it is not known if these channels also exert a growth control function in either isolated epithelial cells or intact epithelia. Unlike in T-cells and fibroblasts, stimulated calcium entry in human epidermal keratinocytes is associated with cessation (rather than enhancement) of proliferation, as well as promotion of the differentiation program [8]. Therefore, although across different cell types IKs may be expected to produce equivalent electrophysiological effects including the enhancement of calcium entry, in epithelial cells typified by keratinocytes this action may serve to limit proliferative activity and promote differentiation, the converse of IK function in T-cells and fibroblasts.
In support of a growth regulatory role for IK channels in human epidermal keratinocytes, the immortalized, non-tumorigenic human keratinocyte cell line HaCaT has been shown to express human IK1 (hIK1) [9]. Interestingly, prolonged exposure of HaCaT to the IK activator, 1-EBIO, was reported to downregulate IK expression, an effect correlated with proliferative inhibition [10]. These results, although complicated by agonist induced channel expression changes, suggest a pro-proliferative role for IK in keratinocytes. Further, although potassium conductances have been reported in studies of primary, non-immortalized keratinocytes, it is unclear if these conductances are due to IK [11, 12]. Thus, the exact physiological role of IK channels in primary human keratinocytes and in intact skin remains undetermined.
Cell Culture
Adult human epidermal keratinocytes (Cascade Biologics, Inc., Portland, OR or Cambrex Bio Science, Walkersville, MD) were cultured per the supplier's instructions in EpiLife Medium with Human Keratinocyte Growth Supplement (bovine pituitary extract, 0.2% v/v; bovine insulin, 5 μg/ml; hydrocortisone, 0.18 μg/ml; bovine transferrin, 5 μg/ml and human epidermal growth factor, 0.2 ng/ml)(Cascade Biologics) in a 5% CO2, 37°C incubator. Basal calcium concentration was 0.06 mM. Stock cell cultures were passaged so as to maintain density at less than 70%, and cultures were not used for more than six weeks after direct receipt from the supplier (typically within 5–10 passages). For gene expression and physiological studies keratinocytes were plated at densities of approximately 30–40% confluence at the start of the experiment. Medium was then refreshed with or without various agents for chronic exposure experiments. Medium and additions were replenished every other day thereafter for the duration of the experiment.
Cell proliferation and toxicity assays
Keratinocytes were seeded in a 96-well plate at 10 × 103/well in standard growth medium. After 2–4 hours (to allow attachment to substrate) test agents and 1 μCi 3H-thymidine (Perkin Elmer Life Sciences/NEN Life Sciences, Boston, MA) were added. Approximately 24 hours later cells were harvested for scintillation counting of incorporated thymidine, expressed as CPM (each experimental group represents mean ± SEM of triplicate samples). The CytoTox 96 Non-Radioactive Cytotoxicity Assay Kit (Promega, Madison, WI) was used to measure potential cytotoxic actions of test compounds.
Standard patch clamp techniques were used to attempt to record hIK1 currents in keratinocytes, and these procedures as applied to IK1 recordings from fibroblast cells have been extensively described ([13–15], and references therein). To facilitate patch seal formation and recording cells were rounded by brief (1–2 min) exposure to trypsin/EDTA, after which they were switched to the bath solution (in mM): 138 NaCl, 9 KCl, 1 CaCl2, 1 MgCl2, and 10 HEPES. The patch pipette solution was 150 KCl, 1 MgCl2, 10 HEPES, with free calcium adjusted via addition of EGTA/calcium as described below. All solutions were at pH 7.4 and between 320–325 mOsm. Pipette resistances were between 2–4 MΩ. Cells were held at -70 mV and stepped to 0 mV (for 100 msec) in the presence of elevated intracellular calcium in order to activate hIK1 or mIK1 channels. Two approaches were used to elevate intracellular calcium to activate calcium-dependent currents. Either the free calcium concentration of the patch pipette solution was set to 10 μM (1 mM EGTA with 10 mM calcium), or the pipette solution contained only 0.1 mM EGTA (see above) and intracellular calcium was increased by extracellularly applying 10 μM calcium ionophore (A23187) for 1–2 minutes. Compounds including A23187 were acutely applied to patch clamped cells by dissolving them in the bath solution, and then pressure ejecting the solution from blunt-tipped micropipettes positioned about 5–10 μM from the cell. All recordings were performed at ambient temperatures (21–23°C).
Skin biopsies
Skin biopsies (5 mm punches) were obtained from healthy donors via the Cooperative Human Tissue Network, Midwestern Division (Columbus, OH). For immediate RNA isolation biopsies were placed into RNALater (Ambion, Austin, TX) at the time of donation and shipped overnight in this solution. For experiments on living tissue biopsies were placed into EpiLife alone (with 1.4 mM calcium) and shipped overnight on ice. Upon arrival in the lab living biopsies were trimmed of extraneous subdermal and dermal tissue, and were cultured in 6-well culture plates in EpiLife (with 1.4 mM calcium) in a 5% CO2, 37°C incubator. Medium with or without test agents was refreshed daily. All skin biopsies were obtained under procedures approved by the Institutional Review Board of the Evanston Northwestern Healthcare Research Institute.
RNA Isolation
Total RNA was extracted from cultured human keratinocytes and skin biopsies with the RNAqueous phenol-free RNA isolation kit (Ambion, Austin, TX). RNAlater (Ambion) preserved skin samples were homogenized in RNAqueous lysis buffer with an IKA Works Ultra-Turrax T8 dispersing instrument (IKA Works, Wilmington, NC). Cell debris were removed from the homogenates by centrifuging for two to three minutes at 12,000 g. RNA was subsequently purified according to manufacturer's instructions. Keratinocytes were washed twice with Dulbecco's Phosphate Buffered Saline then homogenized with lysis buffer directly in culture dishes using a cell scraper. Keratinocyte RNA was purified as per instructions of manufacturer. RNA concentrations were determined by measuring absorbance at 260 nm. Ratios of absorbance at 260/280 nm yielded values between 1.8 and 2.1. All samples were DNase treated for at least 1 hr prior to reverse transcription.
cDNA was synthesized by reverse transcribing 0.5–2 μg of total RNA using Power Script reverse transcriptase (BD Biosciences Clontech, Palo Alto, CA) in a 40 μL reaction. Briefly, samples were pre-incubated at 70°C with 20 ng of random decamers (Ambion) for two minutes, cooled on ice then incubated at 42°C for 90 minutes. Reactions were terminated with a final 15°C incubation for 15 minutes.
Expression levels of the targeted mRNA were quantified by fluorescent real-time polymerase chain reaction using an ABI Prism 7700 Sequence Detector (Applied Biosystems, Foster City, CA). Real-time PCR reactions were performed in triplicate in a total volume of 30 μL containing 1 μL of cDNA, 15 μL of Universal PCR Master Mix (Applied Biosystems), 300–900 nM of each forward and reverse primer and 200 nM of each probe. Gene specific Taq-Man primers and probes were designed and synthesized using the Primer Express software package (Applied Biosystems). Primer and probe sequences for hIK1 were (5'-3'): GTGAACTCCATGGTGGACATCTC (forward), CGGTGTGAGCTGCTCAGATTC (reverse), ATGCACATGATCCTGTATGACCTGCAGC (probe); and, for mIK1: TGCCTTCCTCCTTTGTCTTATTGT (forward), AGCCCGTTGTCAGTCATGAAC (reverse), TCTTCCATGCCAAGGAGGTCCAGC (probe). Probes were labeled with the fluorescence reporter FAM at the 5' end, and the fluorescence quencher TAMRA at the 3' end. GAPDH was detected using primers and a VIC labeled probe purchased from Applied Biosystems as a Pre-developed Taq-Man Assay Reagent. PCR reaction conditions were as follows: two minutes at 50°C to activate uracil-N-glycosylase (Amp-Erase UNG) 95°C for 5 minutes to deactivate UNG, 40 cycles at 95°C for 15 seconds and 60°C for one minute. The relative quantification of mRNA, described as either fold change from control or % of GAPDH, was determined by the comparative Ct method where the target is normalized to the endogenous reference GAPDH. The threshold Ct value is the cycle number arbitrarily selected from the logarithmic phase of the PCR curve where an increase in fluorescence can be detected above background. The ΔCt is determined by subtracting the Ct of GAPDH from the Ct of the target (ΔCt = Ct-target – Ct-GAPDH). The relative value of target to endogenous reference is described as % of GAPDH = 2-ΔCt. Fold change from control = 2-ΔΔCt where ΔΔCt = ΔCt-control – ΔCt-treatment.
To perform end-point PCR for 1281 bp of the 1284 bp coding sequence of hIK1 PCR reactions were run in a reaction volume of 50 μL using Advantage-GC 2 Polymerase with 15 μL of GC melt (BD Biosciences Clontech, Palo Alto, CA), 1X GC 2 PCR Buffer, 200 μM dNTP, 0.4 μM of each primer and 5 μL of cDNA. PCR reaction parameters were as follows: 94°C for 3 minutes, 35 cycles of 94°C for 15 seconds and 68°C 3 minutes, and a final extension at 68°C for 3 minutes. PCR for the amplification of GAPDH mRNA was performed in the same manner except 30 cycles were used and the GC melt was omitted. Primer sequences for hIK1 were (5'-3'): ATGGGCGGGGATCTGGTGCTT (forward), CTTGGACTGCTGGCTGGGTTC (reverse). GAPDH primers (Maxim Biotech, Inc., San Francisco, CA) were (5'-3'): TGCTGGCGCTGAGTACGTCGT (forward), GTGGAGGAGTGGGTGTCGCTG (reverse) yielding a PCR product of 615 bp. PCR products were analyzed on a 1.5% agarose gel stained with ethidium bromide.
Reagents and chemicals
The following compounds were prepared as stocks for application to cell cultures or single cells after appropriate dilution in either culture medium or physiological saline, respectively. VitD (calcitriol; 1,25-(OH)2-D3, Sigma Corp., St. Louis, MO) in DMSO; A23187 in DMSO (Sigma); 50 mM 1-EBIO (1-ethyl-2-benzimidazolinone, Tocris Cookson Inc., Ellisville, MO) in ethanol; 25 mM clotrimazole (Sigma) in ethanol; 10 μM charybdotoxin (Tocris) in 10 mM acetic acid with 0.1% BSA; 1 mM TRAM-34 in DMSO. TRAM-34 was a generous gift of Dr. Heike Wulff (UC Davis School of Medicine). Corresponding vehicle controls showed no effect on cell proliferation, cell toxicity, electrophysiology, or gene expression.
Data Analysis
Numerical results are given as mean ± SEM unless otherwise noted. One-way ANOVA was used for comparisons of treated groups to a control no-treatment group, as well as for pairwise comparisons among treatment groups. The 95% confidence interval was used to assess significance for these analyses.
Results and Discussion
hIK1 mRNA expression in proliferating and differentiating human keratinocytes
The effect of VitD on hIK1 levels was also assessed in cells that had been previously exposed to elevated extracellular calcium, simulating what might occur in intact skin when VitD is therapeutically applied in part because of its pro-differentiating properties. In this experiment hIK1 expression in basal calcium (0.06 mM) was 0.029% of GAPDH, and after 48 hours in 2 mM calcium the value was 0.068%, similar to the result shown in figure 1. In cells that were treated with 2 mM calcium for 24 hours followed by addition of 1 μM VitD for another 24 hours hIK1 expression was 0.165%, again comparable to results shown in figure 1 for 24 hour calcium and VitD exposure. GAPDH levels, which were used to normalize gene expression, varied little in response to calcium and/or VitD (GAPDH Ct difference between untreated and treated cells of 0.2 ± 0.2, N = 9 determinations), further substantiating the robustness of the hIK1 upregulation results.
hIK1 mRNA expression in human skin biopsies
To determine the dynamics of hIK1 expression, hIK1 expression levels were measured as a function of time after biopsy collection and subsequent growth in explant culture (figure 2B). Medium always contained 1.4 mM calcium, a requirement for survival of explant skin cultures [19]. At 2 days post collection (1 day shipping, 1 day in culture) hIK1 expression had decreased to 40% of its initial value, but with an additional 2 days in culture expression had recovered to 60% of its initial value. TG-1 expression showed a similar decrease followed by an increase with culture time, while INV increased insignificantly. Skin biopsies contain dermal fibroblasts that may express hIK1. Although we trimmed much of the dermal tissue from the biopsies used for this study, we cannot completely discount some contribution of dermal fibroblasts to the hIK1 expression results.
Effect of the hIK1 activator 1-EBIO on keratinocyte proliferation
The increase in hIK1 expression under anti-proliferative/pro-differentiating growth conditions (calcium, VitD) was surprising in that increased IK channel expression has typically been correlated with proliferative stimuli and growth [1, 2]. In addition, contact induced proliferative inhibition in the HaCaT keratinocyte line correlated with decreased hIK1 expression [9], and pharmacological downregulation of hIK1 correlated with mitogenic inhibition [10]. However, differentiation marker expression did not increase, and it must be noted that proliferative inhibition is not necessarily coupled to enhanced cell differentiation. Our results correlating increased hIK1 expression with keratinocyte differentiation are, however, consistent with the general physiological model for this channel's function, namely to enhance calcium influx. Thus, in keratinocytes where calcium influx is a differentiation signal, hIK1 would be predicted to have anti-proliferative and/or pro-differentiating functions.
Electrophysiological evaluation of hIK1 functional expression
To assure that the recording conditions were satisfactory for detecting hIK1 activity, we used the same solutions and reagents to evoke mouse IK1 (mIK1) currents in ras-transformed NIH3T3 cells (figure 5). Currents due to mIK1, a homolog of hIK1 [23], were detected in all four cells tested, with current amplitudes ranging from 0.78 nA to 1.68 nA (figure 5). These experiments were performed on the same day that identical recordings failed to detect hIK1 in keratinocytes treated for 3 days with calcium and VitD. The fact that all ras-transformed NIH3T3 cells tested responded with large magnitude mIK1 currents is consistent with previous reports from several groups, including our own, concerning these cells [24, 25].
mRNA levels for mIK1 and hIK1 were measured from cell cultures made in parallel to those used for electrophysiology. hIK1 levels in keratinocytes treated for 5 days with calcium and VitD were approximately half of those for mIK1 in ras-transformed NIH3T3 cells. This level of hIK1 expression was entirely consistent with the initial expression studies shown in figure 1. By comparison, channel mRNA levels in wild type NIH3T3 and untreated keratinocytes were considerably lower. It is important to note, however, that despite the 19-fold difference in mIK1 mRNA levels between wild type (0.41%) and ras-transformed (7.97%) NIH3T3 cells, wild type cells still display readily observable whole cell mIK1 currents at approximately 10% of the amplitude of ras-transformed cells [24, 25]. Further, the mIK1 mRNA level in wild type 3T3 cells is exceeded by hIK1 mRNA levels in keratinocytes from the following treatment groups: VitD for 5 days; VitD and calcium for 3 days; VitD and calcium for 5 days. Therefore, although IK currents can be observed in 3T3 cells expressing mIK1 mRNA at approximately 0.4% of GAPDH, no IK currents were observed in any of the 19 keratinocytes from cultures which express hIK1 mRNA at 0.7 to 4.4% of GAPDH.
Why are no functional hIK1 channels observed despite the fact that hIK1 mRNA is abundant and appears to be physiologically regulated?
Our results showing 1-EBIO inhibits keratinocyte proliferation suggest an involvement of hIK1 in this process, but the hIK1 blocker ChTX failed to reverse this inhibition. 1-EBIO has also been shown to modulate cell growth in the HaCaT keratinocyte cell line, but 1-EBIO and other benzimidazolones also affect chloride (and other) conductances [26, 27]. which are known to be present in HaCaT [9, 28]. Although the presence of chloride channels in primary keratinocytes has not been addressed, it is possible that 1-EBIO affects proliferation in these cells and HaCaT through channels other than hIK1, or through some target yet to be determined. In addition, the electrophysiological effects of 1-EBIO and indeed the presence of hIK1 currents in HaCaT cells have not been subjected to direct voltage clamp analysis [9, 10]., therefore, a critical electrophysiological comparison of these cells with primary keratinocytes is not yet possible. Thus, it appears that although hIK1 is expressed at the mRNA level in primary human keratinocytes as well as skin, functional channels are not formed, and thus cell growth studies utilizing hIK1 pharmacophores must be interpreted with caution.
The critical role for calcium influx in keratinocyte proliferation and differentiation strongly indicates an electrophysiological component to these processes, and hIK1 has been modeled to serve an essential role in controlling calcium mobilization in other non-neuronal, non-muscle cell types. However, our results suggest that the functional electrophysiology of primary human keratinocytes, and possibly intact human skin, does not include hIK1. Further, the lack of functional hIK1 channels suggests caution must be used when interpreting results with IK1 pharmacophores in human epidermal keratinocyte cells and skin.
- ChTX:
glyceraldehyde-3-phosphate dehydrogenase
intermediate-conductance calcium-activated potassium channel
1- [(2-chlorophenyl)diphenylmethyl]-1H-pyrazole
- VitD:
An NSF grant (MCB-0080796) partially supported this research.
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Pre-publication history
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Monday, April 2, 2012
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The first day of spring quarter is coming to an end. Although I didn't get the classes I wanted, I am happy to have applied to all of my internships today. Instead of wallowing in my disappointment of being denied classes I am going to cherish the accomplishment of finishing all of my applications. I am off to celebrate with a heart warming cup of tea. Cheers.
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The Arsenal Gap Year offers an exciting opportunity to get involved in community football coaching with Arsenal in the Community, both in London and overseas. The programme provides an incredible chance to go behind the scenes of major football club and contribute to many of Arsenal's projects in the community.
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Whether you are considering a gap year before or after higher education, or even a career break, you are welcome to apply for the Arsenal Gap Year. Applicants simply need to be over 18 years of age (17 if you are from Scotland or the Republic of Ireland). There is no maximum age.
The programme is split into three stages:
Stage 1 is based in London, at the Arsenal Hub, and lasts 5 months. This stage provides training and development opportunities for our 'Gappers' including coaching qualifications, First Aid, Safeguarding and TEFL courses. 'Gappers' are then placed within PE departments in local schools to build up their coaching experience.
Stage 2 gives our 'Gappers' the opportunity to travel abroad to coach at one of our community programmes around the world for a period of up to 4 months. 'Gappers' also have the choice to remain in London if they do not wish to travel abroad.
Stage 3 provides the chance for a second placement abroad or continuation in London.
For more detailed information on the programme, costs involved and FAQs, please download the Arsenal Gap Year information pack by clicking here.
To download an application form click here
For more information contact: email@example.com