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Hengrui is pleased to work with the talented team at CrownBio to accelerate our commitment to build a globally competitive therapeutic portfolio for Hengrui. Dr. Lianshan Zhang, Hengrui's President of Global R&D,
Santa Clara, CA (PRWEB) January 11, 2012
Crown Bioscience, Inc., a leading global drug discovery company, and Jiangsu Hengrui Medicine Co., Ltd. ("Hengrui"), a major Chinese pharmaceutical company, today announced that CrownBio Taicang Biologics Division, a wholly owned subsidiary of Crown Bioscience, Inc., and Hengrui have entered into a strategic partnership for the discovery and commercialization of a novel therapeutic monoclonal antibody ("mAb") for the Chinese and global market.
CrownBio and Hengrui have jointly evaluated multiple target opportunities and selected one that fits the two parties' strategic interest and strength. With this partnership, Crown Biologics will lead the discovery program and deliver a humanized therapeutic antibody IND candidate. Hengrui will be responsible for further development and commercialization against major life threatening diseases in China and globally. CrownBio will receive research support and success-based incentive payment. "CrownBio is very pleased to establish its second long-term strategic partnership with a leading Chinese pharmaceutical company. This has certainly marked another milestone for CrownBio's China initiative, which leverages our world class talent and drug discovery expertise in a focused disease area to advance innovative pharmaceutical products for patients." Dr. Alex Wu, CEO of CrownBio, commented. "China's bio-pharmaceutical market is entering an unprecedented growth era and poised to become the 2nd largest pharmaceutical market after the US. Our partnership with leading innovation driven pharmaceutical companies, such as Hengrui, demonstrates our commitment to bringing innovative medicines to patients."
Dr. Lianshan Zhang, Hengrui's President of Global R&D, added, "Hengrui is pleased to work with the talented team at CrownBio to accelerate our commitment to build a globally competitive therapeutic portfolio for Hengrui. We expect this partnership will bring two outstanding companies together and create a sustainable and successful long-term collaboration with win-win outcomes."
About Jiangsu Hengrui Medicine Co., Ltd.
Jiangsu Hengrui Medicine Co., Ltd., established in 1970, is a fully integrated pharmaceutical company in China, with net sales of about US$550 million in 2010. The company has been experiencing organic growth at an annual rate of 25% in the past few years. It is recognized as the top innovative home-grown drug company, with over a dozen of new molecular entities in clinical trials and dozens more under pre-clinical development. Hengrui's products and R&D span over multiple therapeutic areas, such as oncology, cardiovascular and metabolic diseases, CNS, inflammation, hematology and anesthesiology. For more information, please visit http://www.hrs.com.cn/.
About Crown Bioscience
Founded in 2006, Crown Bioscience is a premier drug discovery company providing cutting-edge translational platforms and cost effective drug discovery solutions for its biotech and pharmaceutical partners in dedicated therapeutic areas: Oncology and Metabolic Disease. Our proprietary HuPrime®, HuKemia®, HuBase ™, and HuMark ™, platforms enable unique lead optimization and translational strategies to deliver superior clinical candidates. Headquartered in Santa Clara California, Crown Bioscience has operations in China (Beijing and Jiangsu Taicang) and the USA (NC) with business offices in the Boston, Princeton, RTP, Phoenix, Milan and Shanghai. For more information, please visit http://www.crownbio.com.


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Interview With Award-Winning Grads Blake & Diane Cyrier
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Filmmakers, get your work scene at the largest film festival in downtown LA! DTLA Film Festival, the largest film festival in downtown Los Angeles. The historic film fest is accepting student film submissions for the first time ever! The 9th Annual DTLA Film Festival will be held from September 21
Brodie Cooper Wins At IdyllWild Film Festival!
From Animation to Horror, Brodie's filmmaking styles are making waves Brodie Cooper graduated from the Film degree program in 2016. Having grown up with an unreserved love for film, he went to the movie store each weekend to check out both the latest releases, and perennial classics. As a massive
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The deadline for this festival is coming up in February The Grand Foundation's scholarship awarded Student Film Festival is coming up on February 28, 2017. If you are planning to submit a short film, the festival organization would appreciate you letting them know in advance. Submission rules and guidelines are
Children's Film Festival
Announcing Call for Entry Chicago International Children's Film Festival October 27 – November 5, 2017 Submit a film to the largest children's film festival in North America and the first Academy Award qualifying children's film festival in the world. Deadlines. Early: May 1, 2017 — Save $20! Final: May 31,
Pembroke Taparelli Arts & Film Festival
Attend a film festival for a cause Students, staff and alumni are community to attend the The Pembroke Taparelli Arts & Film Festival in its inaugural year. We are a social justice focused film festival; this year's theme is homelessness and domestic violence. We are offering a special student discount
Asian World Film Festival
Asian World Film Festival The 51 countries of greater Asia make up over 50% of the world's population, and produce an outstanding array of fabulous movies each year. Each October the Asian World Film Festival brings the best of a broad selection of quality Asian cinema to Los Angeles to
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4th Annual Los Angeles Turkish Film Festival
The Los Angeles Turkish Film Festival is coming up, and will feature work by some of the most well-respected filmmakers in the world. The 4th Annual Los Angeles Turkish Film Festival will take place between March 9th and 13th at the Egyptian Theater in the very heart of Hollywood. Students

subset: commoncrawl


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Participants gallery
Postindustrial Designers
Adriana Eysler
Jennifer Leonard
» Charlles Pinon
Sarah Frey
Sebastian Adank
Charrles Pinon / User rating prize
Charlles Pinon
Recife / Brasil
Curriculum vitae
I started working at Coca-Cola Co. as a Finance Trainee, then I went to a Finance Investment Group. Leaving the dark financial issues behind, I started working at a company that deals with high technology for mobile devices, Meantime Mobile Creations. Here I'm Marketing Analyst.
Business Administration, Universidade de Pernambuco, Recife, Brazil
Graphic Design, CEFET - PE, Recife, Brazil
What are you doing right now?
I'm working a lot at Meantime, but in the free times I try (with some other design students) to develop a group of postmodern studies. We are focused on brazilian and mundial studies of Design, but raising our own concepts - mixing diverse theories together as maximalism and minimalism. Noise, destruction, reconstruction, visual-pollution and clean layouts designs, that's our issues of studies.
What is your understanding of designing?
Designing is undestanding the universe of whom you want to reach, is the high visual comprehension and sometimes the materialization of a world that is not properly of the creator. I like metaphors, so designing is some lack of ME to fill the empty space with THEM, the consumer mass. Actually we know that one designer's conception may vary from another's, we print our personal mark on the works, however a design project is not done to reach OUR conceptions but our public's SOUL.
What are criteria, that make a project interesting for you?
Esthetic, decisively. Depending on the concept of the idea, mesmerizing the consumer is the goal of a well built design project. It does not mean that projects must be expensive and complicated, but use concepts that can produce beauty and the observer admiration, that's the most important, to make jaws go down, even when taking simplicity to the work. Designers deal with feelings, the most profitable human resource and esthetic touches our heart with a higher potential. It's great to have the tools to make people laugh, cry, admire, be unquiet...
On what kind of "Postdindustrial Design+ projects have you been working on?
By now, I'm just developing a group that will take care of an eletronic magazine raised to be a window to our views on design.
What should be the main skills of a Postindustrial Designer?
First, empathy - the ability to enter into another feelings and emotions; second, execution - the ability to transform the empathy knowledge into real design. I really consider the ability to express human feelings as a great skill.
e-Mail interview, July 1st, 2005
initiated by students


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In order to take advantage of the organizational system in SI Lead Manager you must place Tags on Leads. You can be as broad as you want or as narrow as you want when picking which tags to place on which leads. You can tag leads when you first add … [Read more...]
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The Add New Lead form is a quick and simple way to enter a new lead into SI Lead Manager. It is a one page form that just requires that basic lead information. You'll be asked to enter the leads name, property address and mailing address. All … [Read more...]
Filed Under: Beta 6, Front Page, Help, Leads, Manager, New Lead // Tagged: Add Lead, Mailing Address, New Lead, Property Address, Tags


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From Wikipedia
An incubus (nominal form constructed from the Latin verb, incubo, incubare, or "to lay upon") is a demon in male form who, according to a number of mythological and legendary traditions, lies upon sleepers, especially women, in order to have intercourse with them. Its female counterpart is the succubus. An incubus may pursue sexual relations with a woman in order to father a child, as in the legend of Merlin.[1] Religious tradition holds that repeated intercourse with an incubus or succubus may result in the deterioration of health, or even death.[2]Medieval legend claims that demons, both male and female, sexually prey on human beings – generally during the night when the victim is sleeping.
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Ìgbọ̀nsẹ̀ kékeré létí àwo gbẹ̀gìrì, bó bá kúrò lójú, kò lè tán lọ́kàn. /
A drop of faeces on the edge of a plate of bean soup, even if overlooked by the eyes, won't be ignored by the mind…..Yoruba Proverbs!
[Watch the indiscretions; misdeeds may be overlooked, but they are seldom forgotten]
All religion are valid as long as it teaches peace and love…. Obara Meji!
There are no disappointments in life, only lessons learned!….Obara Meji
Written by
Obara Meji
Metaphysics Teacher
Obara Meji is a spiritualist, Ifa-Orisa practitioner, and teacher of metaphysics. Since 2011 she has used her online platform to share her personal experiences to those seeking answers about spirituality. Her teachings will expand into short stories, novels, and public speaking to continue her mission of bringing enlightenment to the world.
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69 Comments on "INCUBUS SUCCUBUS-A PEEPER SHARED HER STORY"
Murder!!! Yazzzy yaz out fi kill me looooooool mi kno yu serious but is di way yu type it LML buff mi land a grung
Mawnin all my sweeties!!! Kia boooo, Cami boooo and mi empress Obara! and all the fam!
Ms. Anonymous, large up pan yuh story. The moment you shared it you became bigger than it….
Affi shout out all di peepers dem cawz mi rate unuh and from unuh a peep unuh belong here… true story.
I also wanna share a quickie experience since di whole a we a dash out (LOL)
I was in an on again off again relationship with my then guy and at that particular time we were "off" and I was super lonely and IN SERIOUS HEAT! (Lmfaooooo plz nuh judge!!)
I had a "roomie" that was a guy (much older and certainly not my type) but on this night who gave a #&*$…. I arrived home from a long day at work and I don't know what the hell "possesed" me but I knew I was gonna need a sex slave that night! (LMFAOOOOOOOOOOOOO!!!!!!!)
So there I was in my hallway plotting for my roomie who stood no chance as I spoke aloud that "I WILL BE "SERVED" on this very night" ((he just happened to be my quick prey)) I spoke this aloud several times and even tek up mi high chess guh get "prepped" a.k.a "MOHAWKED" for the unknown ((LAWD A MASEEEHHH!!!! )
A suh mi know seh these entities are always on the prowl cah sure enough is like a spell was casted pan di poor likkle roomie cah as him reach eeen (notice seh a ongle when bwouy reach eeeen di strang "possession" tek him ova) and BRAPS (memba now eenuh… him nuh know my thoughts and my "declaration") he was acting so enchanted (a wah use di wud creepy but a mi call it dung pan miself lol)….
Long 'tory shawt… di "possessed" creep, crept into my room and tan up ova mi fi how long dis a stare mi dung… den him hen hup hunda mi sheet… hunda mi frack tail a pull a Lewinsky!!! I frighten suh tillllllllllllll. … no joke.. cawz a big chat mi did a mek mi neva serious … WELL.. sure enough, as declared, YAZZY TUN BIG DOMINA to rastafari!!!!! (minus di sex ) … mi know mo did posses to how mi beat dat man and tun him hinna mi sexual bwouy toy! Oh gawd man…. mi shame!!
Good morning Obara Cami Yazzy Yaz morning sunshines Love n light Peace n blessings to you all n your loved ones.
Me see part II so I'll start reading it so it can lull me off to sleep…see you'll around 8/9 tonight.
Hey Yazzy!
Cami yuh up??
Morning everybodddy! Yazzy yu check in before going off to work ((muah)) have a great day to you and all who work in the am. Obara! put it like this…I was up but now sleep ready fi set in.
Obara mawnin mi sweetie!!!
Good morning my dears! Anon don't feel no way. We are some of the most non judgemental ppl you will ever meet. I too can raise my hand and say I have been victim to the dutty duppies a time or two. Obara, like how you say sex dreams are never good, is there a deeper meaning to them. For example, like they say when you dream marriage it means death. I'm not sure what I was going through at the time those beings visited to me but it might be because I wasn't having sex at the time. I never said the word celibate but maybe it was my lonely energy. Idk lol. Love and light guys. Shout out to my loves yaz, mth, cami, ty, kiab, toy, nuns, yw, all es family, and especially the mama hen Obara!
Mawnin Mi sweetie Sea! Hailments boo. So lovely to see ya! Kisses…
Thanks for sharing your experiences as well.
((Muah))) SQ…wonder how many other brave souls will state their nightly experience. Ty/Obara imagine the deep waves readings if electronically monitored.
Anon, of all my years of having those 'fantastical', sexual sleep events I've never heard anyone else share such experiences. I know them and know them well…
"did I pick this up from the high sexual energy in her house because of her work?"
You belong over here with us because you know things subconsciously.
I swear this is some juicy stuff! Anon, thank you for sharing this. I've had experiences similar (zero out the club and group sessions), but yours is a wow!
I'm still reading, but before I got to Glory dreaming you I knew she had that experience too (going back to the bolted door and grilled windows)…mines I assume comes from molestation which I strongly believe open the victim up to some pathways…
I love the sharing of the experiences…
Good evening ALL, Yazzy me sight you good to see you.
Obara, lolol…please to cite the bible story them because I have very minimum knowledge of them…members where can I find this bear story? lol
Camiiiii!!! Mawnin sweetie. Mi miss yuh eenuh ooman!
Hi everyone! Thank you for sharing your story. No judgement! That was a good question did you pick up that sexual energy from the lady. For some reason I really love this story.
Shana babygirl… What's up?? I love seeing ya shades! thought its an emotional story isn't it amazing??? I'm fascinated with experiences such as this
Night Yazzy yaz Yailings Toy
Kia mi hotta a sista! I missed you boo!! Loads of hugs and kisses. And kiss mi nephew to boo. I hope you and the family are well! Muah!
Hey Kia Bubblez
Toy Booooo mi love yuh too sis! A nuh O alone love mi!! LOL! Mi and yuh a Papa Obatala Pickney!
Yes big up our fada! lol Obatala We love him
Nunu yuh know from when you and I nuh kick back pan di endz and run a boat and pap a bakkle and reason!
Yuh know seh a nuh suh wi live eenuh!
Mi dis done wuk. I'm planted here now. Couldn't tief weh nuh time earlier.
I'm gonna ketch up pan di comments quick quick wid di Q&A and come…
Yazzyyyyy!!!!! Mi glad fi si yuh!
Nunu Boooooooooo!!! MI GLAD FI SEE YUH TOOOOOO OOO MI INCREDIBLY SWEET SIS!!!! A BARE HUG AND KISS!!!
Obara can a succubus cause a miscarriage? This lady said she was pregnant and an entity that looked like slightly like her husband forced himself on her and she lost consciousness. She said she told her husband when he got home and he said it was all in her head it was probably dream paralysis. If it is in fact true, how is it that the baby's ori didn't protect the fetus from this malevolent energy?
Yes they can cause mis-carriage Nunu, I am sure you know that not every body who gets pregnant gets to bring it to full term. This may have been the way the Fetus chose to go, (that happens) some from our soul group choose only to experience the womb of the human, they opt not to be born. Also, they may want to teach the woman or man something by allowing this entity to invade her, or the man might have brought about this energy by fooling around outside, the possibilities are many, but this is how the child chose to go. We are all Actors on the stage of life.
Good question Nunu. I can't wait for the answer.
Den Toy yuh nuh muss did tiad, mi love how oonuh real over here, oonuh tek afta mi, Thank you so much Toy for sharing and making an already comfortable anonymous more comfortable, I love you!
love you too OM! muahh
Toy yuh mek mi buss out a laugh a while ago ie nuh star!
Nunu for real
Hi everyone, Obara Hello! Yazzy glad to see you. Nunu, Kia. Obara the train of men put down, huh. lol. Hi Anonymous you don't have to feel bad, it is your past. I use to sleep with 3 or 4 guys in one day everyday. I use to be so tired. Anyway, meditating and using your Ori to guide you through you will be great. I hope you can blog with us one day.
why would someone want to call them?, they are sexual demons, malevolent beings, and can be invoked by many mediums, even your thoughts. Dark seedy places brings them forth, like night clubs,some dances, sex scenes, 42nd street lol
Yailings NUNU Hey Obara why is that the incubus/sucubus visit you all when you never send call dem? what make them come aid you when you celibate or whatever?
hry kia! nunu it sound like the dead , but dem odda ones could mek she feel so iuh
Greetings all thank you Anon for sharing your experiences in such depth. I am glad you have overcame that journey in your life. Luckily you survived with your physical and seemingly your mental still in tact. I can only imagine it was a horrible experiences for you at such a young age.
That I know of I experienced an incubus visitor once. I remember in my dream state, (I probably was astral projecting) seeing the black black like midnight figure but could not make out his facial features. He was on top of me. Also I remember my inner thighs being sore. I think I shared it with Obara and she explained then that having sex in dreams was NOT A GOOD THING! That plus eating in your dreams is forbidden.
Greetings sistren Kia!
Peeper mi glad fi yuh ie nuh mumz cause dealing wid dem tings nuh easy. Juss gwaan work on yuhself, raise your vibrations and things will keep getting better
Nunu I love our peeper as well. C'mon man Ms. Anonymous, yuh bravely sent in such an amazing post you just need half that courage fi come blog wid wi man. Cho man. A mek ya mek it look suh?? Love your style Ms. Anonymous!
Was I Possessed or something?
Yes they can posses you, I am not sure if your were possessed, but you were certainly under their influence
Obara the hand that touched her on her breast that first time was cold, was that someone that just died?
The discharge may have been from orgasms you had, I am sure for how long it went on, could you tell me, so I ca answer your question correctly
Was it her who came to my dream and tell me to stop or my guide disguised as her?
It was her spirit, it seems as if she had this with her which led her to her chosen career, you missing your parents, being vulnerable and lonely and also in the place where the sexual energy was high and also these beings lived there, these beings already familiar with the woman attached themselves into a very vulnerable girl.
Why seeing her in the dream commanding me to stop, remove all these urges from me immediately, did she have something to do with my plight?
Did they really have sex with me Obara, if not, then why did I feel the pain when I dreamed them woke up, what was the leaking about?
No not physically, because there is no physical body, but the force and images were sent to your mind, and so you experienced the sex acts that way, and believe it or not this way is even more potent than the real deal.
Did somebody set them on her and I picked it up?
I do not know if someone set them on her or not, it may be possible, but you definately picked it up through her energy I believe
O, could the energy have come from the male "boyfriends" of Glory base on the extreme that Anon was taken to?
I believe Glory has an abuse background but the deprave acts against Anon seems like a collection of the men's energy.
Yes Cami it may have also, it is I suspect a concerted effort, with Glory being the first victim before Anon, this is transference of bad energy. It is never good to jump and sit in a seat someone just got up from, before you do o, hit the chair several times, this will remove what belonged with the person who just got up an not allow them to latch on to you.
Ms. Anonymous I thought your questions were great. Obara you just know how to answer a damn question! Genius!
Nunu big up!… mi nuh hear from de mumzie
Shi want mi fi call yuh fi her but mi deh read done fuss
Obara so what is the difference between spirits from the soul group doing it and the incubus spirits doing it??
is it preventable?
Is there ever a time when this spiritually sexual experience ok??
Yazzy, the soul group are from your spiritual family, although sex with them is not to be encouraged. The incubus Spirits are malevolent and belongs to a particular realm where they will tempt humans in their dreams or waking state of very disturbing salacious sex acts, I believe they are the one who penetrate the minds of pedophiles, rapist, de gully Queens dem, Bruce Jenner (bout him ah tun ooman) and Jenna Jameson to name a few,
No one knows when they will visit or try to tempt, it is preventable, but then again who is on the look out for them, they appear at will and usually at night, although they travel in the day time also,
Sex with Spirit, any spirit form is NEVER OK!
lolol, O my little 'visitor' came during abstinence…
Obara thanks for some Clarity. I was so gonna ask if the benevolent beings that come to "aid" us And heal us with their many gifted ways… why can't sex be one of them. Like they embrace us sometimes when we need to be hugged so why aren't they allowed to make love to us if there is so much power in Love and in the act of love making??
Ps, yes I am very much aware I am coming off as a total NUT right now!! LOL!
Good morning people! Yazz, Court and Teach big ups fo you
oonuh si Vybz Kartel name inna de tag?..mi cudden helo miself, lol
Yazzy ah love de energy you bring to de blog, mi love yuh spirit mi nah lie!
Yazzy with me, I had been celibate for a while, by choice, I had just gone through my first initiation and had gotten rid of the tinking germz box, dead dog, wicked dranco, son of a bitch him mumma ah one fi choot) baby father, and mi was like a new born.
I had a lot of spirits around me and I told someone on the phone that I was not doing the deed.Mi neva sey mi crave it or long fi it, I am not like that, if it is not around, mi still good. They heard and decide fi battrey mi, Ma it nice ei si, mi nah lie de bwoy (non physical as they were galang bad wid mi and mi galang bad back wid dem!
When mi wake up ah tiad like mi push one heavy truck up hill. My mentor Mr. Pierre laughed when I told him and said I must never bawl out aloud again that I was celibate, they came to please me….a doe ask if they didn't!! Shame fi even tell oonuh
In a post you relate VK (can't stand the dude) to the antics of Lilith.
Obara I can't get to see the tags when using my cell but TAG di bwouy yes! Lol!
Obara thanks for the nice statement you made about me. I pull from all the amazing energies here…
Lawd a one ting we nuh fenneh fi do and a style up ppl weh fi get stylementz!! Bwouy get style up suh till mi shame fi him!! it's well deserved! Lmfaooooo. Style him Obara style him!
Listen mi… mi dis come back and mi mash up a dan when mi was lassss ere… suh tek time wid me Obara bout seh yuh was "like a NEW BAWN" lawd mi baddiieeee!!!! Weh yuh seh Obara yuh was LYNCHIN' dem time deh???? if a drop a grung one more time!!
I think it's freakin crazy how they just showed up to sawt out kitty all chuuuu yuh seh yuh Celibate… (Obara just as I wrote that last piece I am curious how these non physicals understand our languages and their meanings since there are so many languages in the world…)
Is it the actual word "Celibacy" they heard and came to what now appears to have been your rescue **wink wink** ((they came to your rescue, get it??? Di way how yuh love it off)) …yes sorry, I digressed… so was it the actual word… or was it the energy coming from the word… or was it the state you were in (the state of celibacy) or was it a combination of all the above… ??
Hi Courtney, I will check it as soon as ah done…
Yazzy ah one miss call mi get from you call me nung, aws mi cudden fine mi phone
Good morning family.
Hope everyone had a blessed weekend. Very interesting post on sexual energies.Anonymous no judgement here we all have our experiences and your brave to share love and light sweetie. Hugs
O do these sexual energies play a role in the sexually addicted.i know all energies have a place and do they play a part in our journies when certain experiences are to bring about change?
Check your mail O.
Courtney babygirl!! What's good??? LONG TIME!! Happy fi see yuh sweetie…
Mi nah guh bite mi tongue! Obara a wah kinda dutty… nassy… tinkin… ole tiefing …crosses long (c)jockey crawny (is some good name dis mi a use style him) Obeah man dat bout seh him affi ruxxx off di ppl dem underage virgin gyal pickney! Yuh see seh some a dem full up a nuff shit! KMFT!
It would have torn me up if our peeper had to experience any further trauma from the initial exposure…. So happy that tho you were 14 Ms. Anonymous. ..you knew what you stood for and you stood up to that ass!
Obara I do recall your sexual (battry) experience and that "THEY" were from your soul group (correct me if mi wrong cah yuh wuda cry shame fi know seh likkle young gyal head a gada bare wata).
Obara so what is the difference between spirits from the soul group doing it and the incubus spirits doing it??
is it preventable?
Is there ever a time when this spiritually sexual experience ok??
***mi soon come wid more questions but since our peeper asked so many I wanted to wait for the answers to those first***
Yazzy weh yuh deh?
Nunu mi sis mi did deh a wuk wid eyes on me couldn't come back till mi done just now…
Happy Monday my sweetie Obara (mi did get likkle worried cah mi ben call yuh ova di weekend and a don't get yuh! suh mi STALK yuh here! LOL! )
Happy Monday to alllll my sweeties here! Mi miss unuh bad! LOVE & LIGHT
Happy Monday to all peepers esp our very Own Ms. Anonymous! Big ups on a very emotional story told so very well and for having VICTORY over your lesson!


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Cannoli Numero Uno: The Sweet Taste of Freedom
There have been a lot of discussions on blogs of late about the violence, anger and rudeness associated with the reaction to the marriage amendments that have passed in several states. These negative reactions have primarily and largely been from the homosexual community. Some believe this is necessary as the gay community is fomenting revolution and they may do so by any means necessary. Others take a more balanced and sane approach and realize that making enemies of their position is not the correct way to proceed.
On one side of the argument are religious fundamentalists. Included in this group, but not limited to are the Mormons and Evangelical Christians. Their position is that a marriage is between one man and one woman (at one time Mormons allowed one man and many women, but currently this is not the case). This position is consistent with Judaism and Christianity as it is related to scripture and doctrine. I think this position is fine from the standpoint that people have a right to their religious beliefs, even if it conflicts with what others believe, and as long it is not illegal.
On the other side of the argument we have the gay community and other liberal minded folks. Gays believe that marriage, as a legal instrument through the government, should be open to any two human beings. It would be my guess that some also believe it should be allowed in all churches and synagogues, but I do not know the full extent to of that. In an effort to promulgate equality, some states have legislated that gay marriage is legal. In other states, changes to marriage law if you will have been attained through the courts. The rub of late is that four states passed referenda that defined marriage as between a man and a woman. I believe those states are California, Arizona, Michigan and Florida.
The reaction by the gay community has been dramatic and at times violent, intrusive, rude, disgusting and illegal. Going into houses of worship and throwing used condoms on parishioners, spray painting churches, engaging in sex acts in church bathrooms, and other disruptive acts during services is the wrong thing to do and it causes people that would otherwise support gay rights with marriage to the very least turn away in indifference. Some have told me it is a revolution that must be won by any means necessary. Some believe as I do, others have remained indifferent. So where's the beef?
The problem is that we are dealing with two different authorities. One is common law and the other is religious law. Article I of the Bill Of Rights states: "Congress shall make no law respecting an establishment of religion, or prohibiting the free exercise thereof". This portion of the first amendment affirms what it believed to be a natural right that people may believe and worship as they desire and just as important, the government shall not have an official religion. The reason for this is that at the time of the founding documents, England and other countries had official religions. In England, in order to hold certain positions in government or academia, a person had to be a member of the Church of England. In the case of the latest skirmish in regards to gay marriage, some of the religious folk have been accused of taking Church doctrine and law, and trying to create legislation based on it. I believe this is arguably true. Conversely, is it true that the gays are trying to change church doctrine? More accurately, it is seen that the gay agenda is trying to change the very moral fabric of society.
If gays were trying to change church law and doctrine, I would agree that is egregious in that using the current methods it would be an infringement of people's religious freedoms and it would also be intolerant. Again, people have the right to believe as they wish. I am not so sure this is the case and if it is, they lost me here. On the other hand, I think they are correct in wanting equality in the eyes of the law. What religious fundamentalists seem to not realize is that in order to make a law that marriage is only between a man and a woman, I believe that the only way to do this legally, is to make homosexuality illegal. I cannot for the life of me see how this would be possible. In my opinion, gays are born that way. Just as a black person cannot change their skin color, a gay person cannot change their inborn sexuality. The rub with bible thumpers is that they believe that homosexuality is a choice. This has to be true for them because if they admitted that homosexuals were born that way it would imply, due to scripture and church doctrine, that god made a mistake. This is where I believe the conflict arises with them. God can't make mistakes. As Obama said, that is above my pay grade. All I know or believe is that they were born the way they are, just as I was born the way I am. Was it a mistake? Ask god.
The only solution I see to this mess is a separation of church and state. The first assumption is that marriage is a religious concept. Only churches can marry and it is in the eyes of god. On the other hand, for marriages to be recognized by the state for legal purposes, there exists a legal standard in issuing of a license for that purpose. Only the state can regulate the legal aspects of a common law union. So, to this effect, the state should create or change marriage licenses to common law union licenses for everyone. This document establishes a legal relationship so as to settle estates, living wills, probate, etc. If the people who obtain a common law union license wish to have their marriage recognized in a religion, which is up to the religion to decide who may or may not be married in their church/synagogue. Through this separation, equality can exist within the natural rights of people.
"Jefferson believed that each individual has 'certain inalienable rights.' That is, these rights exist with or without government; man cannot create, take, or give them away. It is the right of 'liberty' on which Jefferson is most notable for expounding. He defines it by saying rightful liberty is unobstructed action according to our will within limits drawn around us by the equal rights of others. It is not 'within the limits of the law,' because law is often but the tyrant's will, and always so when it violates the rights of the individual." Hence, for Jefferson, though government cannot create a right to liberty, it can indeed violate it. And the limit of an individual's rightful liberty is not what law says it is but is simply a matter of stopping short of prohibiting other individuals from having the same liberty. A proper government, for Jefferson, is one that not only prohibits individuals in society from infringing on the liberty of other individuals, but also restrains itself from diminishing individual liberty (Appleby and Ball, p224, 1999).
The previous paragraph is how I see liberty and freedom on this earth and in the universe. If we could all live by this, which is an extension of Christ's commandments, do unto others as you would have them do unto you, we all would be better off. What prevents this, in my opinion, is that people want power. In an ideal state of liberty and freedom, no one, including the government, has more power than any other individual or entity. Human beings, due to their survival instincts, look for an advantage. Part of an advantage is to look for power over others. Be that as it may, the quest for power relegates the desire for equality to second place. I think this is something that some wish not to admit. Take this particular issue, if my solution was implemented, which I believe offers the greatest chance at justice and equality, I would bet that neither side would be satisfied because equality is not the ultimate goal of either side. It is the promulgation of their respective agendas and the power that would be gained by the hegemony thereof that may be the true goal. If this is the case, then a pox on both your houses.
The latest war on liberties demonstrates the quest for power. The Mormons and other religious groups use the government to promulgate their religious views in law. The gay community is infringing on people's individual right to practice religion when they perpetrate acts in religious places and moreover, expose people that contribute as individuals to campaigns that promulgate religious views. In as much as the courts may strike down the referenda, a person's individual right to practice religion and participate peacefully in a political process should not be violated by anyone. What baffles me about the rude and unlawful behavior is that in every case that I recall, the courts have struck down such referenda. My question is, why the militant behavior? Considering gays account for less than 10% of the population, it's a literal fight that can't be won by those means, and I would suggest it won't end well in the end. My advice would be to use the courts to seek justice in this case, and the legislature if necessary, but above all, the rights of people on both sides of the issue must be respected if we are to have equality and justice. My favorite civil rights advocate is Frederick Douglass. While Mr. Douglass said "Power concedes nothing without demand. It never has and never will. Show me the exact amount of wrong and injustices that are visited upon a person and I will show you the exact amount of words endured by these people." Demand does not equal unlawful, disgusting or rude acts. While I believe there are instances where people may act in kind, or in effect to defend oneself, this is not one of them.
Thank you for reading this blog.
Appleby and Ball (1999) Letter to Isaac H. Tiffany, April 4, 1819 from Thomas Jefferson


text: Brad Pitt has a new job. Angelina Jolie's other half and newly-dubbedd fiance, 48, is the new face of Chanel No. 5, making him the first man to represent the scent in the brand's history. He joins Nicole Kidman, Lauren Hutton, Ali McGraw and Catherine Deneuve as spokesmodels for the fragrance.


text:
It is safe to say that my sugar free cravings and side effects have all gone. I definitely feel much better overall. There have been lots of temptations along the way but I have avoided them! Giving myself a target has definitely been a great motivation for this journey. I cannot believe that I have gone this far without drinking diet coke. Drinking water every night didn't feel natural at first but now I just fill a glass from the tap without thinking!
I have also not had a proper dessert since I started this. The closest I came to having a dessert was a sugar free all natural banana bread, it didn't feel like a dessert! I can see weight coming off the scales, but more importantly I can feel my clothes loosening. At Christmas even my baggiest clothes were feeling tight and that scared the shit out of me.
One evening my girlfriend decided to indulge in some cadburys chocolate. Cadburys chocolate is my weakness, it was such a cruel thing to do! But guess what! I DIDN'T HAVE ANY! My will power is getting very strong now. Whatever happens next, I know that I don't have to be greedy and there is always an option to say no to things that are bad for me.
I know though that next week I am going to birthday parties in restaurants and that will be a new challenge. I am not sure if it is possible for me to pick something healthy or not? I want to try my hardest. In restaurants they tend to sneak in posts of hidden calories so I'm not sure. They're both Italian restaurants so maybe an Italian Salad with no cheese? It's like having chicken Kiev with no breadcrumbs or garlic butter!
I know that this can't go on forever. Life is too short to COMPLETELY deprive myself of things I enjoy. I have decided I want to have something bad soon. I am conscious though that having something bad doesn't mean opening the flood gates to eat every bad thing in site. I believe that a discipline would be to have something bad and then to revert back to this sugar free diet. I don't want to turn into one of those health freaks that have tofu three times a day and weigh 2 stone.
I need something food wise to look forward to which is naughty but I don't know what this is yet. If anyone has any tips on dieting when in restaurants I want to hear them!


text:
Beyond the Streak by Jason King.
A wealthy oligarch and two working-class dudes, one black one white, sit at a table with ten cookies.
The oligarch grabs nine cookies for himself then says to the white dude, "Watch out for that black dude, he wants a piece of your cookie!"
Looks like your connection to KU Buckets was lost, please wait while we try to reconnect.


text:
MILAN (Reuters) - World stocks stayed near peaks and currencies moved in tight ranges on Wednesday as China's Communist Party conference opened and the focus in Europe turned to speeches from top euro zone central bankers before next week's key policy meeting.
World stocks stayed near peaks and currencies moved in tight ranges on Wednesday as China's 19th Communist Party Congress opened while focus in Europe turned to speeches from top euro zone central bankers before next week's key policy meeting, as well as Catalonia's ultimatum due on Thursday. S&P futures are solidly in the green as usual, with Dow futures jumping above 23,000, driven higher by IBM as investors looked for new reasons to extend gains after hitting new all-time highs Tuesday.
BRUSSELS: Europe's central banks are struggling with divergent quandaries over how to revive inflation and sustain economic growth as the US Federal Reserve prepares to start raising interest rates for the first time since the collapse of Lehman Brothers. The world's major economies are recovering at very varying paces from seven years of economic and financial crisis, with Japan tipping back into recession and China trying to surmount a severe wobble this year.
LONDON/BENGALURU: A collapse in oil prices that gave a windfall to the world's energy consumers and a flurry of policy easing from central banks might have been expected to brighten the outlook for global economic growth. But Reuters polls of more than 250 economists across Europe and North America show only modest upgrades to growth forecasts and a reluctance to relinquish a depressed inflation view, despite the rush of rate cuts and central bank cash that most respondents believe is far from over.
NEW DELHI: A partly hawkish, partly dovish money policy from the European Central Bank (ECB) caused some ripples in global financial markets overnight, but Dalal Street looked cold to the developments on Friday morning.At its policy review, the ECB decided to scale back its bond purchases to 60 billion euros a month from April (till December 2017) compared with 80 billion euro a month at present.
LONDON: From the Swiss franc's record rise in January to the near certainty of a historic US interest rate hike in December, 2015 was a far more volatile year for financial markets than most predicted 12 months ago. Bond yields across Europe plunged well below zero, the Dow Jones fell 1,000 points in one day in August and turmoil in Chinese stocks turned a downturn across emerging markets into a rout. No fewer than 43 central banks eased policy. While the direction of these moves may have surprised few observers, the scale, speed and depth caught most off guard.
LONDON: The U.S. Federal Reserve and European Central Bank are expected to deliver sharply contrasting policy decisions next month, reflecting how the world's two largest economies have moved from the Great Recession to the Great Divide. The U.S. and euro zone central banks have been on a similar path of monetary easing since the financial and economic crisis of 2007-09. But the Fed is now poised for "liftoff", delivering its first rise in interest rates for almost a decade, while the ECB is expected to flood the market with more deflation-busting stimulus.
LONDON/MILAN: European shares edged higher on Wednesday, buoyed by good company earnings and expectations the US Federal Reserve will decide to keep rates near zero at today's policy meeting. The pan-European FTSEurofirst 300 was up 0.4 per cent at 1,475 points after falling 1 per cent in the previous session. The euro zone's blue-chip Euro STOXX 50 index was up 0.6 per cent. The Fed is expected to leave interest rates unchanged on Wednesday and may struggle to convince sceptical investors it can tighten monetary policy before the end of the year in the face of slowing U.S.
AS WE write this week, the IMF's latest World Economic Outlook suggests that the world economy has had a bumpy ride of late but looks stronger than it did when the year began. There are plenty of things that could go wrong, of course, but the main threat continues to be Europe. The good news there is that a euro zone which continues to merely bungle along on its present course shouldn't be too dangerous for the world outside of the euro area's immediate backyard.
World stocks started the week in the red Monday as the dollar touched a 7-month high and U.S. and European government bond yields climbed to their highest since June following the Friday speeches by Eric Rosengren and Janet Yellen which hinted the Fed's next step could be to pursue a steepening of the TSY yield curve the same as the BOJ.
With nearly $2 trillion in 5-year-and-in eurozone govies sporting sub-zero nominal yields and with ~16% of global government debt sitting in NIRP territory, it's abundantly clear that the idea of the "market" (a word which at this juncture has virtually no meaning) functioning as a price discovery mechanism is now absurd.
Bullfax.com - Market News & Analysis 2008-2011 Contact Us | About Us | Terms & Conditions


text:
August 24, 2010
CAMBRIDGE, MA - A team of students at the Massachusetts Institute of Technology is busy testing a rapid-recharging system for electric vehicles, the MIT News Office reported.
These student researchers have already performed extensive testing of the system with an individual battery cell and with a motorcycle they converted to all-electric operation. In coming months, they hope to demonstrate the system on a full-sized sedan they converted. The goal is to demonstrate that recharging can be accomplished routinely in under 30 minutes without severely reducing the operating lifetime of the batteries or causing other problems.
In the year since the MIT Electric Vehicle Team started working on the project, new and established companies have begun to offer commercial rapid-recharging systems. What's more, Japan has officially adopted a new standard for the connectors for such systems and has begun installing the systems in more than 100 locations.
The Nissan Leaf, a pure electric five-passenger car to be introduced in the U.S. later this year, is already capable of rapid recharging in 30 minutes in places that have the necessary "Level III" charging system. But so far, just one such station exists in the U.S. That's in Portland, Ore., MIT said. Lennon Rodgers, a doctoral student in mechanical engineering and a member of the MIT Electric Vehicle Team, presented a paper on the team's rapid-charging tests at the 12th International Conference on Advanced Vehicle and Tire Technologies in Montreal. The paper was co-authored by fellow team members Radu Gogoana, a master's student in mechanical engineering; Paul Karplus, an undergraduate at Stanford; and Michael Nawrot.Rapid charging, also known as Level III, requires much higher voltages and current than what's supplied by conventional household circuits. The Japanese rapid-charging standard, called CHAdeMO, provides DC power at up to 500 volts with a current of 125 amps.
Typical chargers operate on standard AC power, using either 110 volt household current (Level I), which generally can recharge an electric car's batteries overnight, or special systems that use 220 volts (Level II), which can cut the charging time in half.
"Rapid charging" systems typically refer to those that can charge the batteries to at least 80 percent of capacity within 30 minutes. This fast-recharge technology might be installed in central recharging stations comparable to today's gas stations, where the cost of the necessary infrastructure could be warranted and where a fast turnaround is necessary, MIT said. In many cases, rapid charging systems can provide a 50 percent charge -- typically enough to travel 50 miles -- in under five minutes. That's comparable to the time it takes to fill a gas tank.
Jack Firriolo from Merchants will answer your questions and challenges
Find your closest station or plan a route. Locate biodiesel, electric, ethanol, hydrogen, compressed natural gas (CNG), liquified natural gas (LNG), and propane across America.
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text:
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text:
Monday February 1, 2016
Key Datapoints:
Key Developments :
- Down gap bought and SPX completes a 50% retrace
- Bullish Inverse H&S patterns see minor follow thorough
Today's gap down to open February was bought in the first half hour. In fact it was bought right at the pre-market low on the SPY. We should keep these levels in mind because as we can see the first intraday support came in just below the pre-market low; while the first resistance, just above the pre-market high.
The rest of the day the market kind of chopped around with the typical bull market 1:30 – 3:45ish rally and then profit taking into the close.
It was sort of a choppy grind higher as the market attempted to digest the big move from Friday. However, with the backdrop of the inverse H&S patterns targeting 1967.41, and no reversal patterns in sight, it is best to trade on the long side and buy dips until either the targets are acquired or a major reversal pattern presents itself. It has not yet.
It is possible we get further consolidation with the 50% retrace having been acquired, but we still have a bullish pattern in motion, so we must respect that until we have price action that threatens the breakout from Friday.
The Bottom Line:
The bulls did a nice job so far protecting most of Friday's gains. We still have bullish patterns in motion targeting higher prices. We must watch for any reversal patterns or further follow through on this bounce to acquire the first upside target at 1967.41.


text:
Sponsored By
Steelers Announce Dates And Times For 2016 Preseason GamesThe Steelers announced dates and times for all four of the team's 2016 preseason games which will air on KDKA-TV.
Steelers Announce Preseason Game Start TimesThe Pittsburgh Steelers have announced the start times for four of their five preseason games.
Steelers Announce Dates And Times For Home Preseason GamesThe Steelers announced today their 2014 preseason schedule with some familiar exhibition opponents.
Steelers Announce 2014 Preseason ScheduleThe Steelers announced today their 2014 preseason schedule with some familiar exhibition opponents.
Penguins Release Preseason Schedule The Pittsburgh Penguins won't have much time to dwell upon what could have been as the preseason will open up in a couple of months.
Pens Release 2012 Preseason ScheduleWith the Stanley Cup being presented to the Los Angeles Kings on Monday, it's time to start looking ahead to next season. On Wednesday, the Penguins announced their upcoming preseason schedule for the 2012-13 campaign.
Shea-ved Ice: Penguins Release Preseason ScheduleThe Pittsburgh Penguins released their preseason schedule for the start of the 2011-12 season on Monday.


text:
I was in the eighth grade when I was introduced to the sugar-coated-sugar-crystals known as Nerds. The first one I had was the grape/strawberry combo and to this day, it's still the one I prefer. If I had my choice, however, I would only have strawberry. Grape and strawberry are not both favorites; I am only partial to strawberry. Oh, I'll choke the grape ones down, but pink is the way to go. When Halloween rolled around a few years ago, I noticed that stores were selling large bags filled with miniboxes of grape and miniboxes of strawberry and my dream had been realized. I hoarded and devoured the strawberry while passing off the lesser grapes to unwitting trick-or-treaters. SUCK IT, SPIDERMAN!
The situation suited me nicely until I started realizing that the distribution of the flavors was not equal. Invariably, there were more boxes of grape than there were strawberry. Was it a manufacturing decision or did I gobble up the strawberry so quickly that it just seemed there were less present? Disgruntled but too incapable of movement after the sugar coma, I forgot about the injustice until the next Halloween rolled around. THIS year, however, I decided to conduct a scientific study and report my results for the public's edification.
TEST ONE (conducted by my cousin): 10 strawberry, 17 grape
TEST TWO (conducted by me): 10 strawberry; 18 grape
I was ready to stop there (I do have a dentist appointment coming up after all) but in the interest of science, I decided to go for an even odd three.
TEST THREE (conducted by me): 23 strawberry; 17 grape.
UN-BE-FRAKKIN-LIEVABLE! Clearly this was a mutant package (how are there 10 more boxes than the previous results in the first place?) and should just be thrown out lest it skews the statistics. If you happen to give Nerds away this Halloween, please report your findings so that we can publish the results in whichever prestigious scientific journal will take them.


text:
(B&W, 1941, 101 minutes)
Andy's gone and done it this time. All set to graduate from high school and he flunks his English exam - in spite of the
fact that Aunt Milly is his teacher, and that the Judge has gone to all the trouble of getting him his very own private
secretary (Kathryn Grayson in her screen debut).
What makes this Andy Hardy movie, according to The Hollywood Reporter "even better than the wildly cheered
Love Finds Andy Hardy?" It could be Mickey Rooney's irresistible charm. Or could it be the perfected plot of Andy
juggling his steady love (Polly Benedict) with his growing affections for another girl? Or perhaps it's the non-stop
laughs Rooney generates with such antics as trying to buy ladies' hose or letting the judge take a spin in his jalopy in
the pouring rain.
Whatever the case, here's your chance to return to a simpler and happier time with the family America loved to love.1
Directed by: George B. Seitz
Assistant Director: Gilbert Kurland
Screen Play by: Jane Murfin and Harry Ruskin
Based on a story by Katharine Brush
Based upon the Characters Created by Aurania Rouverol
Musical Direction: Herhert Stothart
Art Director: Cedric Gibbons
Associate: John S. Detlie
Set Decorations: Edwin B. Willis
Recording Director: Douglas Shearer
Director of Photography: Lester White
Film Editor: Elmo Veron
Released: February 1941
Lewis Stone ... Judge Hardy
Mickey Rooney ... Andy Hardy
Fay Holden ... Mrs. Hardy
Ann Rutherford ... Polly Benedict
Sara Haden ... Aunt Milly
Kathryn Grayson ... Kathryn Land
Ian Hunter ... Steven V. Land
Gene Reynolds ... Jimmy McMahon
George Breakston ... "Beezy"
Todd Karns ... Harry Land
Addison Richards ... Mr. Benedict
Margaret Early ... Clarabelle Lee
Bertha Priestley ... Susan Wiley
Joseph Crehan ... Peter Dugan
Lee Phelps ... Barnes
John Dilson ... Mr. Davis
Additional Cast:
Hooper Atchley ... Conductor
Frederick Burton ... Gov. Spaulding
Donald Douglas ... Mr. J. O. Harper
Ken Christy ... Policeman
Hal K. Dawson ... Salesman
Mary Field ... Saleswoman
Betty Jane Graham ... Student
George Guhl ... Station Master
George Noisom ... Messenger
June Preisser ... Euphrasia Clark ("Phrasie Daisy")
Erskine Sanford ... Mr. Bosinny
Charles Smith ... Bob, delinquent in court
C. M. Wyrick ... Service Station Man #1
Elliott Sullivan ... Service Station Man #2
Musical Program:
[0:46] Voices of Spring [Strauss] (sung by Kathryn Grayson)
[1:26] Graduation March
[1:27] Ardon gl'incensi (Mad Scene from the opera LUCIA DI LAMMERMOOR by G. Donizetti, sung by Kathryn Grayson)
[1:31] I've Got My Eyes on You [Porter] (sung by Kathryn Grayson)
Buy Kathryn Grayson CDs
Lewis Stone, Ian Hunter, Kathryn Grayson, Mickey Rooney
Harry and Kathryn Land(Todd Karns and Kathryn Grayson)
Ian Hunter as Steven V. Land
Mickey Rooney as Apollo
Kathryn Grayson as Kathryn Land
Margaret Early as Clarabelle Lee
Ann Rutherford as Polly Benedict
Mickey Rooney and Ann Rutherford
1from back of videotape sleeve
Crew and Cast credits from film title reel; additional cast from various sources.
Andy Hardy Fan Site ©2007 Jim Johnson - see copyright statement


text: Some left over strips of paper from a project were transformed into these beautiful birds. Kids rolled the strips onto a pencil, and removed them. The quills were expanded as per the requirements and the end glued. Sometimes more than one color was used together. For the body, the quills were pinched together at one end. Open curls were added for the tail and an accordion pleated strip for the crown.


text:
BRIEF Bendamustine and Rituximab In Elderly Follicular (BRIEF)
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT01313611
Recruitment Status : Terminated (Treament with rituximab during maintenance phase was stoped, according to DSMC recommendations, since 3 cases of deaths occured.)
First Posted : March 14, 2011
Last Update Posted : March 7, 2018
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
The objective of this study is to evaluate the complete response rate after a short induction treatment with rituximab (375mg/m2)and bendamustine (90mg/m2)in In Elderly (≥ 60 years old) patients with untreated Follicular lymphoma, with an intermediate or high FLIPI score and without high tumor burden.
This short induction is followed by a rituximab (375mg/m2)maintenance/ Induction schedule:Rituximab+Bendamustine on Day 1, Bendamustine on Day 2, Rituximab on Day 8, Rituximab on Day 15, rituximab on day 22, Bendamustine on Day 29, Bendamustine on Day 30 Maintenance schedule: 12 infusions of rituximab, each 8 weeks
|Condition or disease
|Follicular Lymphoma
|Drug: Rituximab + bendamustine
|Phase 2
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|62 participants
|Intervention Model:
|Single Group Assignment
|None (Open Label)
|Primary Purpose:
|Official Title:
|BRIEF: Bendamustine and Rituximab In Elderly Follicular: A Multicentric Phase II Study Evaluating the Benefit of a Short Induction Treatment by Bendamustine and Rituximab Followed by Maintenance Therapy With Rituximab In Elderly (≥ 60 Years Old) Patients With Untreated Follicular Lymphoma Patients, With an Intermediate or High FLIPI Score
|Actual Study Start Date :
|February 2011
|Actual Primary Completion Date :
|October 2012
|Actual Study Completion Date :
|December 2017
|Experimental: Rituximab + bendamustine
Drug: Rituximab + bendamustine
Induction phase: rituximab and bendamustine on Day 1, Bendamustine on Day 2, Rituximab on Day 8, Rituximab on Day 15, Rituximab on Day 22, bendamustine on Day 29, Bendamustine on Day 30
- Complete response rate according to Cheson criteria 1999 after a short induction treatment by rituximab and bendamustine [ Time Frame: 12 weeks ]
- Complete response rate according to Cheson criteria 1999 after 24 months of maintenance therapy with Rituximab [ Time Frame: 26 months ]
- Partial and objective response rates at the end of induction phase [ Time Frame: 12 weeks ]
- Duration of response [ Time Frame: From the time of attainment of CR or PR to the date of first documented disease progression, relapse or death from any cause ]
- Progression free survival [ Time Frame: From the date of randomization to the date of first documented disease progression, relapse, initiation of new anti-lymphoma therapy or death from any cause. ]
- Overall survival [ Time Frame: From the date of randomization to the date of death from any cause ]
- Time before retreatment [ Time Frame: From the end of primary treatment until the institution of the next therapy ]
- Immediate toxicity [ Time Frame: 12 weeks ]
- Long term toxicity [ Time Frame: Until death of the patients ]
- Evaluation of QoL [ Time Frame: 7 years ]
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|60 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Histologically confirmed follicular lymphoma CD20+, all grades except the grade 3b with a lymph node biopsy performed within 6 months before study entry and with material available for central review
- A minimal initial immunology is required, including : CD20, bcl-2, CD10 and CD5
- Age must be ≥ 60 years
- Patients not previously treated
Patients with an intermediate or high risk FLIPI score requiring 2 or more of the following adverse prognostic factors:
- Age >60 ans
- Ann Arbor Stage (III-IV vs. I-II)
- Hemoglobin level ( < 12g/dL vs. ≥ 12 g/dL)
- Number of nodal areas (< 5 vs. ≥ 5) (Note: LDH should not be considered as an adverse prognostic factor in this study since it is considered as high tumor burden in the GELF criteria)
- Low burden disease at study entry according to the GELF criteria
- Patients with at least one measurable site of disease: patients with only blood or marrow or splenic infiltration are excluded
- Performance status ≤ 2 on the ECOG scale
- Adequate hematological function (unless abnormalities are related to lymphoma infiltration of the bone marrow) including:
- Hemoglobin ≥ 8.0 g/dL (5.0 mmol/L)
- Absolute neutrophil count (ANC) ≥ 1.5 x 109/L
- Platelet count ≥ 100 x 109/L
- Adequate renal function: calculated creatinine clearance > 50 ml/min (according to MDRD method) unless these abnormalities are related to lymphoma
- Adequate hepatic function: Total bilirubin < 2.0 mg/dl (34 µmol/L), AST (SGOT) and ALT (SGPT) ≤ 2.5 x the upper limit of normal unless these abnormalities are related to lymphoma
- Adequate cardiac function: LEVF ≥ 50% calculated by echocardiography or scintigraphy
- Having previously signed a written informed consent
Exclusion Criteria:
- Other histological types of lymphoma than follicular lymphoma
- Grade 3b follicular lymphoma
- Patients previously on watch and wait since more than 6 months from diagnosis
- Patients previously treated for lymphoma, except splenectomy
- Patients with low FLIPI score (0 or 1 adverse prognostic factors not considering elevated LDH)
- Bulky disease at study entry according to the GELF criteria
- Presence or history of CNS disease (either CNS lymphoma or lymphomatous meningitis)
- Patients with prior or concomitant malignancies except non-melanoma skin cancer or adequately treated in situ cervical cancer or previous cancer in CR without any treatment in the last 5 years
- Positive HIV, HBV (anti-HBc positivity) and HCV serologies before inclusion
- Poor Performance status > 2 on the ECOG scale
- Known contra-indication to study product
- Serious underlying medical conditions, which could impair the ability of the patient to participate in the trial (e.g. ongoing infection, uncontrolled diabetes mellitus, gastric ulcers, active autoimmune disease).
- Any other co-existing medical or psychological condition that will preclude participation in the study or compromise ability to give informed consent.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01313611
Hide Study Locations
|ZNA Stuivenberg
|Antwerpen, Belgium, B-2060
|Clinique Sud du Luxembourg
|Arlon, Belgium, B-6700
|Baudour, Belgium
|A. Z. Sint-Jan
|Bruges, Belgium, B-8000
|CHU Brugmann
|Bruxelles, Belgium, B-1020
|Université Libre de Bruxelles - Hôpital Erasme
|Bruxelles, Belgium, B-1070
|Université Catholique de Louvain Saint Luc
|Bruxelles, Belgium, B-1200
|CH Notre Dame
|Charleroi, Belgium, B-6000
|CHU Charleroi-Vésale
|Charleroi, Belgium, B-6000
|Centre de Santé des Fagnes
|Chimay, Belgium, B-6460
|Clinique Notre Dame de Grace
|Gosselies, Belgium, B-6041
|Hôpital Jolimont
|Haine Saint Paul, Belgium, B-7100
|CH Hutois
|Huy, Belgium, B-4500
|AZ Groeninge - Campus Maria's Voorzienigheid
|Kortrljk, Belgium, B-8500
|CHU Tivoli
|La Louviere, Belgium, B-7100
|CHR de la Citadelle
|Liège, Belgium, B-4000
|CHU de Liège
|Liège, Belgium, B-4000
|CHU Ambroise Paré
|Mons, Belgium, B-7000
|Clinique Saint Joseph
|Mons, Belgium, B-7000
|Hôpital Sainte Elisabeth
|Namur, Belgium, B-5000
|Heilig Hart Ziekenhuis
|Roeselare, Belgium, B-8800
|Centre Hospitalier de Wallonie Picarde - CHwapi
|Tournai, Belgium, B-7500
|CH de la Tourelle-Peltzer
|Verviers, Belgium, B-4800
|UCL Mt Godinne
|Yvoir, Belgium, B-5530
|CH du Pays d'Aix
|Aix En Provence, France, 13616
|CHU Amiens - Hôpital Sud
|Amiens, France, 80054
|CHU d'Angers
|Angers, France, 49033
|CH Antibes
|Antibes, France, 06606
|CH Victor Dupouy
|Argenteuil, France, 95107
|CH d'Avignon - Hôpital Henri Dufaut
|Avignon, France, 84000
|Hôpital de Bayonne
|Bayonne, France, 64100
|Centre Hospitalier de Beauvais
|Beauvais, France, 60021
|CH Jean Minjoz
|Besancon, France, 25030
|Centre Hospitalier de Blois
|Blois, France, 41016
|Institut Bergonié
|Bordeaux, France, 33076
|Polyclinique Bordeaux Nord Aquitaine
|Bordeaux, France, 33300
|CH Dr Duchenne
|Boulogne sur mer, France, 62200
|CH de Bourg en Bresse
|Bourg en Bresse, France, 01012
|CHU Morvan
|Brest, France, 26609
|Centre Hospitalier de Brive
|Brive La Gaillarde, France, 19100
|CH Béziers
|Béziers, France, 34500
|CHU Clémenceau
|Caen, France, 14033
|Centre Francois Baclesse
|Caen, France, 14076
|CH Cannes
|Cannes, France, 06401
|CH Chambéry
|Chambéry, France, 73011
|CH de Chartres
|Chartres, France, 28018
|Hôpital de Châlon
|Châlon sur Saône, France, 71100
|Hôpital Antoine Béclère
|Clamart, France, 92140
|Hôpital d'Instruction des Armées Percy
|Clamart, France, 92141
|CHU Estaing
|Clermont-Ferrand, France, 63003
|Pôle Santé Publique
|Clermont-Ferrand, France, 63050
|CH de Compiègne
|Compiègne, France, 60321
|Hôpital Sud Francilien
|Corbeil Essonne, France, 91108
|Hôpital Henri Mondor
|Créteil, France, 94010
|CHU le Bocage
|Dijon, France, 21034
|CH de Dunkerque
|Dunkerque, France, 59385
|CH Fréjus St Raphaël
|Fréjus, France, 83608
|CHU Grenoble
|Grenoble, France, 38043
|Centre Hospitalier de Guéret
|Gueret, France, 23000
|Hôpital Bicêtre
|Kremlin Bicêtre, France, 94275
|CHD Vendée
|La Roche sur Yon, France, 85925
|Centre Hospitalier de Laval
|Laval, France, 53015
|Hôpital André Mignot
|Le Chesnay, France, 78157
|CH Le Mans
|Le Mans, France, 72000
|Clinique Victor Hugo - Centre Jean Bernard
|Le Mans, France, 72015
|CHRU de Lille - Hôpital Claude Huriez
|Lille, France, 59037
|CHU LIMOGES - Hôpital Universitaire Dupuytren
|Limoges, France, 87042
|CH de Bretagne Sud
|Lorient, France, 56100
|Clinique de la Sauvegarde
|Lyon, France, 69009
|Centre Léon Bérard
|Lyon, France, 69373
|CH les Chanaux
|Macon, France, 71018
|Institut Paoli Calmettes
|Marseille, France, 13273
|CH de Meaux
|Meaux, France, 77100
|Ch Marc Jacquet
|Melun, France, 77011
|Hôpital Notre Dame de Bon Secours
|Metz, France, 57038
|CH Saint-Eloi
|Montpellier, France, 34295
|CRCL Val d'Aurelle
|Montpellier, France, 34298
|Centre Azuréen de Cancérologie
|Mougins, France, 06250
|CHU de Mulhouse - Hôpital Emile Muller
|Mulhouse, France, 68070
|Centre Catherine de Sienne
|Nantes, France, 44000
|CHU Hôtel Dieu
|Nantes, France, 44093
|Hôpital Américain de Paris
|Neuilly, France, 92202
|Centre Antoine Lacassagne
|Nice, France, 06189
|CHU de Nice
|Nice, France, 06202
|CHU Caremeau
|Nimes, France, 30029
|Clinique Valdegour
|Nimes, France, 30907
|CHR de la Source
|Orléans, France, 45067
|Hôpital Saint Antoine
|Paris, France, 75012
|Hôpital de la Pitié Salpétrière
|Paris, France, 75013
|Hôpital Necker
|Paris, France, 75015
|Hôpital Hôtel Dieu
|Paris, France, 75181
|Institut Curie
|Paris, France, 75181
|Hôpital St Louis
|Paris, France, 75475
|Hôpital Saint Antoine
|Paris, France, 75571
|CH Saint Jean
|Perpignan, France, 66046
|Hôpital Haut Levêque
|Pessac, France, 33604
|Centre Hospitalier Lyon Sud
|Pierre Bénite, France, 69495
|CHU de Poitiers - Hôpital de la Milétrie
|Poitiers, France, 86021
|CH René Dubos
|Pontoise, France, 95300
|Centre Hospitalier de la Région d'Annecy
|Pringy, France, 74374
|Hôpital Robert Debré
|Reims, France, 51092
|Clinique de Courlancy
|Reims, France, 51100
|Hôpital Pontchaillou
|Rennes, France, 35033
|Centre Henri Becquerel
|Rouen, France, 76038
|Clinique Mathilde
|Rouen, France, 76100
|Centre René Huguenin
|Saint Cloud, France, 92211
|CHU de Saint Malo
|Saint Malo, France, 35400
|CHU Saint-Etienne
|Saint Priest En Jarest, France, 42271
|CH de Saint Quentin
|Saint-quentin, France, 02321
|CHG St Germain
|St Germain en Laye, France, 78105
|Hôpital Font Pré
|Toulon, France, 83056
|CHU Bretonneau
|Tours, France, 37044
|Hôpital de Troyes
|Troyes, France, 10000
|CH de Valence
|Valence, France, 26953
|CHU Nancy Brabois
|Vandoeuvre les Nancy, France, 54511
|Centre Hospitalier Bretagne Atlantique
|Vannes, France, 56017
|Institut Gustave Roussy
|Villejuif, France, 94805
|Principal Investigator:
|Pierre FEUGIER, MD
|CHU Brabois, 54511 Vandoeuvre les Nancy
|Responsible Party:
|The Lymphoma Academic Research Organisation
|ClinicalTrials.gov Identifier:
|NCT01313611 History of Changes
|Other Study ID Numbers:
|First Posted:
|March 14, 2011 Key Record Dates
|Last Update Posted:
|March 7, 2018
|Last Verified:
|March 2018
Additional relevant MeSH terms:
Lymphoma, Follicular
Neoplasms by Histologic Type
Lymphoproliferative Disorders
Lymphatic Diseases
Immunoproliferative Disorders
Immune System Diseases
Lymphoma, Non-Hodgkin
Bendamustine Hydrochloride
Antineoplastic Agents
Immunologic Factors
Physiological Effects of Drugs
Antirheumatic Agents
Antineoplastic Agents, Alkylating
Alkylating Agents
Molecular Mechanisms of Pharmacological Action


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Jean T. MarrusMarch 24, 1935 ~ November 20, 2017 (age 82)
Hurley – Jean T. Marrus of Russell Road died Monday, November 20, 2017 at Health Alliance Hospital Broadway Campus. She was 82. She was born in Mt. Vernon, NY a daughter of the late Robert and Margaret Shirras Troup. A Registered Nurse, she graduated from nursing school in White Plains. She was employed by Kingston Hospital, for 20 years, retiring in 1993. On March 9, 1957, she married Jay Marrus in the 1st. Presbyterian Church in Mt. Vernon. Jean and her husband enjoyed camping. Surviving in addition to her husband is her son Glenn (Sonia) Marrus of Wallingford, CT and her sister, M. Kathleen Troup of East Chester, NY. Three grandchildren, Ricky Marrero, Victoria Marrus, Glenn Marrus II and three great-grandchildren, Leah, Ricky Jr. and Noah also survive. A daughter, Victoria J. Marrus died July 2, 1995. Entrusted to the care of A. Carr & Son Funeral Home, 65 Lucas Ave., Kingston. Cremation and inurnment are private. Donations in Jean's memory may be directed to the Ulster County SPCA, 20 Weidy Rd., Kingston, NY 12401. To leave a message of condolence, please visit www.Carrfh.com
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text:
With Current Valuations M&As are Scarce
By Peter Winter
BioWorld Insight Editor
BioWorld Insight Editor
Friday, July 26, 2013
Mergers and acquisitions have always been a regular staple in the biotech industry . . . until this year that is. Can it be possible that there won't be at least one blockbuster deal executed by the end of December?
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Carbuncles lined the stargazer's mask, swallowing the moonlight to glow; when any faces peered into those cut garnets, they had no more will of their own than mannequins. They could only peer into the gems adorning that pale clay mask and promise to never leave. Their wallets would be slaughtered like pigs and hung in the trophy room.
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text:
God, come to my assistance.
Lord, make haste to help me.
Glory be to the Father and to the Son, and to the Holy Spirit.
As it was in the beginning, is now, and ever shall be, world without end. Amen
Psalm 101
Promised Faithfulness to the Lord
A Psalm of David.
I will sing of mercy and justice;
To You, O Lord, I will sing praises.
I will behave wisely in a perfect way.
Oh, when will You come to me?
I will walk within my house with a perfect heart.
I will set nothing wicked before my eyes;
I hate the work of those who fall away;
It shall not cling to me.
A perverse heart shall depart from me;
I will not know wickedness.
Whoever secretly slanders his neighbor,
Him I will destroy;
The one who has a haughty look and a proud heart,
Him I will not endure.
My eyes shall be on the faithful of the land,
That they may dwell with me;
He who walks in a perfect way,
He shall serve me.
He who works deceit shall not dwell within my house;
He who tells lies shall not continue in my presence.
Early I will destroy all the wicked of the land,
That I may cut off all the evildoers from the city of the Lord.
Glory be to the Father and to the Son, and to the Holy Spirit. As it was in the beginning, is now, and ever shall be, world without end. Amen
WORSHIP (Optional)
(A short time of worship and thanksgiving, led or spontaneous. Alternatively a devotional song may be played and listened to.)
2 Samuel 3:1-25
Abner Joins David
There was a long war between the house of Saul and the house of David. And David grew stronger and stronger, while the house of Saul became weaker and weaker.
And sons were born to David at Hebron: his firstborn was Amnon, of Ahinoam of Jezreel; and his second, Chileab, of Abigail the widow of Nabal of Carmel; and the third, Absalom the son of Maacah the daughter of Talmai king of Geshur; and the fourth, Adonijah the son of Haggith; and the fifth, Shephatiah the son of Abital; and the sixth, Ithream, of Eglah, David's wife. These were born to David in Hebron.
While there was war between the house of Saul and the house of David, Abner was making himself strong in the house of Saul. Now Saul had a concubine whose name was Rizpah, the daughter of Aiah. And Ish-bosheth said to Abner, "Why have you gone in to my father's concubine?" Then Abner was very angry over the words of Ish-bosheth and said, "Am I a dog's head of Judah? To this day I keep showing steadfast love to the house of Saul your father, to his brothers, and to his friends, and have not given you into the hand of David. And yet you charge me today with a fault concerning a woman. God do so to Abner and more also, if I do not accomplish for David what the Lord has sworn to him, to transfer the kingdom from the house of Saul and set up the throne of David over Israel and over Judah, from Dan to Beersheba." And Ish-bosheth could not answer Abner another word, because he feared him.
And Abner sent messengers to David on his behalf, saying, "To whom does the land belong? Make your covenant with me, and behold, my hand shall be with you to bring over all Israel to you." And he said, "Good; I will make a covenant with you. But one thing I require of you; that is, you shall not see my face unless you first bring Michal, Saul's daughter, when you come to see my face." Then David sent messengers to Ish-bosheth, Saul's son, saying, "Give me my wife Michal, for whom I paid the bridal price of a hundred foreskins of the Philistines." And Ish-bosheth sent and took her from her husband Paltiel the son of Laish. But her husband went with her, weeping after her all the way to Bahurim. Then Abner said to him, "Go, return." And he returned.
And Abner conferred with the elders of Israel, saying, "For some time past you have been seeking David as king over you. Now then bring it about, for the Lordhas promised David, saying, 'By the hand of my servant David I will save my people Israel from the hand of the Philistines, and from the hand of all their enemies.'" Abner also spoke to Benjamin. And then Abner went to tell David at Hebron all that Israel and the whole house of Benjamin thought good to do.
When Abner came with twenty men to David at Hebron, David made a feast for Abner and the men who were with him. And Abner said to David, "I will arise and go and will gather all Israel to my lord the king, that they may make a covenant with you, and that you may reign over all that your heart desires." So David sent Abner away, and he went in peace.
Just then the servants of David arrived with Joab from a raid, bringing much spoil with them. But Abner was not with David at Hebron, for he had sent him away, and he had gone in peace. When Joab and all the army that was with him came, it was told Joab, "Abner the son of Ner came to the king, and he has let him go, and he has gone in peace." Then Joab went to the king and said, "What have you done? Behold, Abner came to you. Why is it that you have sent him away, so that he is gone? You know that Abner the son of Ner came to deceive you and to know your going out and your coming in, and to know all that you are doing."
The Word of the Lord.
Thanks be to God.
Pause for Reflection……
(Take a moment to bring to God any issues that have arisen during the morning. You may like to end with the following prayer…)
Lord Jesus, we thank you for the work of the morning,
For the challenges faced and the obstacles overcome.
Grant that the rest of this day be used for your glory,
As we offer ourselves afresh to you. Amen
(If these prayers are taking place before food, you may like to say the Grace here also.)
GRACE (Optional)
(If these prayers are taking place before food, you may like to say the Grace here instead.)
Lord God, we thank you for your gift to us of this food;
Produce of earth, sky, many living beings, and much hard work.
May we eat with prayerfulness, gratitude and moderation;
With renewed minds and spirit-controlled appetites.
May we eat with compassion for those who hunger today,
And in such a way that reduces the suffering of all creatures;
Healing and preserving our precious planet.
Use this food to strengthen our bodies, revive our spirits,
Nurture our family and nourish our resolve;
That we may continue to serve all that lives with all our life. Amen
Psalms taken from the New King James Version®. Copyright © 1982 by Thomas Nelson. Used by permission. All rights reserved. Other Scripture taken from the ESV® Bible (The Holy Bible, English Standard Version®), copyright © 2001 by Crossway, a publishing ministry of Good News Publishers. Used by permission. All rights reserved.


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Continued from page 1
In order to launch these real-time features for its platform, Facebook needed a way for users to access them. That's why it launched the ticker earlier this week. The ticker shows what your friends on Facebook are doing right now. If you see that your friend is watching The Daily Show, you can watch it with him. If she is reading an article on The Washington Post, you can read along with her. (The Post, whose CEO Don Graham is on Facebook's board, launched its own deep Facebook integration today as part of the launch.) With a music application, if you see that your friend is listening to a cut from the new Wilco album, you can click "listen" and your own version of that application will sync with your friend's—you will be listening together to the song. As many friends as you want can end up joining in to your music experience, which continues until you log off. "We see the Web as a place where people are really doing stuff," says Cox. "It's like if you're sitting in a chair at a cafe and watching people go by—now you can join them in what they're doing."
Facebook has always had a major weakness—it was fundamentally asynchronous. You looked at your news feed to see what your friends had already done. While that retrospective quality will remain a big part of the user experience, Facebook is also today introducing numerous features to make viewing past activities much more enjoyable and controllable. That is the explanation for the profile changes. Think of this part of the new Facebook, which will be rolled out slowly over coming months, as a full-featured scrapbook of your entire life, including everything you've ever done in any app if you want it to.
Most Facebook applications up until now have been pretty awful, with the exception of games. But these changes may allow for the emergence of more useful apps. The idea is that joining with your friends in activities they're doing now should make your mutual experience more productive, fun, or emotionally resonant. And the new profile changes make it much easier to discover what your friends are doing in apps or elsewhere on Facebook.
This kind of product evolution is not simple. Zuckerberg likes to be methodical, and aims to roll things out sequentially in a way that allows one change to lead to the next. Before Facebook could launch its original platform it had to have a way for users to know what applications their friends were using. That's one of the main reasons it launched the news feed in September 2006. Once the feed was established, Facebook could launch its platform the following May. This time, the distribution tool—the ticker—launched only two days before the platform capabilities. But it was as necessary for these new changes as the news feed was for the original platform.
There was a lot of talk in the digisphere preceding today's event that Facebook was going to announce a tight new partnership with social music streaming company Spotify (one of my favorite new services), and a couple other music businesses. While it did partner with Spotify and others in music, news, and video to demonstrate these new capabilities today, the new platform is by no means limited to the launch partners. This set of changes aims to benefit the entire Facebook application ecosystem, though some aspects of it will take a while to roll out.
That's consistent with how a true platform company would operate. Facebook does occasionally work closely with one application in order to make it especially functional for users, but it prefers not to favor any one application over another, thereby keeping its platform neutral. The most notable recent exception was its partnership with Skype. But making Skype work properly on Facebook required deeper unique integration. The two companies had to modify Facebook's "signaling layer" to let users make voice and video calls with Facebook friends.
The best way to think of Facebook is as infrastructure—the social infrastructure of the Internet. Zuckerberg believes Facebook has far more to gain over the long term by reinforcing itself as a universal platform than by any other means. Owning a platform can make for an extraordinarily good business. Microsoft reigned for years as the wealthiest technology company primarily by dint of its ownership and cultivation of Windows—the universal platform for applications on the PC.
Granted, it is potentially problematic for one company to own an essential piece of Net infrastructure. The Internet up until now has been a form of public trust, its protocols and systems not controlled by companies. Managing that contradiction will remain a challenge for Facebook's interactions with governments, regulators, and the public.
But give this company its due—it is a phenomenal innovation engine. It does not rest. It constantly changes itself. Zuckerberg knows that, as Andy Grove of Intel famously said, "only the paranoid survive." The successful emergence of Google's own social network, Google+, has given concrete justification to Zuckerberg's paranoia. Now Facebook has a creditable competitor for the first time. These changes, and plenty more to come, are its response.
For more information about the Techonomy 2011 conference (Nov. 13-15), visit www.techonomy.com. You can also follow Techonomy on Twitter and Facebook.


text:
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text:
Artistry Audio
View our Indiegogo Campaign.
The Tradesman is an organic, light-to-mid-range transparent overdrive pedal that is designed to be unobtrusive yet enhance all of the sweet sounding, rich harmonics from your equipment while pushing your signal into overdriven bliss. This is not your run of the mill overdrive - the Tradesman was built to inspire! With heightened playing sensitivity, a musical and versatile tone shaping EQ, enough headroom to sing the sweet blues, but enough thick drive to cut through the mix...you will be heard!
- Handcrafted solid Oregon black walnut enclosure - every pedal is truly one-of-a-kind
- Studio-grade components and original circuitry designed in the USA by Tone Whizard Labs, exclusively for Artistry Audio
- Solid USA-made aluminum knobs for Volume, Gain, and Tone
- Organic, mostly transparent overdrive ranging from light crunch to mildly aggressive tones
- Custom-designed input stage for superb sensitivity, signal integrity, and incredible headroom
- 4558-based soft-clipping stage utilizing 1N4148 diodes
- Click-less, true bypass switching to preserve signal integrity
- Studio-inspired "Tilt" EQ for optimum versatility
- Boost toggle takes your entire signal to the next level
- Space-saving top-mounted jacks
- Powered by any standard pedal power supply
- (2017-09-27) "The Tradesman" by Artistry Audio - IndieGoGo Campaign by Artistry Audio
- (2017-10-25) Artistry Audio Tradesman Overdrive by shnobel
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Nicotine Gum Market report focuses on the major drivers and restraints for the key players. Nicotine Gum Market research report also provides granular analysis of the sales, market growth market share, segmentation, revenue forecasts and geographic regions of the market.
Nicotine gum is a smoking cessation product that helps smokers to slowly overcome nicotine addiction. Nicotine is released by chewing the gum and is absorbed into the blood stream through the lining of the mouth, which helps smokers to slowly reduce their craving for nicotine. It is one of nicotine replacement therapies (NRT's) and it is an over-the-counter medication. The nicotine gum is available in various dosages and can be consumed per the level of addiction.
Browse Detailed TOC, Tables, Figures, Charts and Companies Mentioned in Global Nicotine Gum market research report @ http://www.marketreportsworld.com/10241651
Nicotine Gum Market Segment by Type:
Nicotine Gum Market Segment by Applications:
Nicotine Gum Market Segment by Manufacturers:
Ask Sample PDF @ http://www.marketreportsworld.com/enquiry/request-sample/10241651
Nicotine Gum Market Analysis by Region:
Key questions answered in Nicotine Gum market report:
Purchase Report @ http://www.marketreportsworld.com/purchase/10241651
Nicotine Gum Market Report Also Covers In-depth Analysis Sales Channel, Distributors, Traders and Dealers:
For Any Query, Contact Our Expert @ http://www.marketreportsworld.com/enquiry/pre-order-enquiry/10241651
In Nutshell, the report focuses on global major leading Nicotine Gum Market players with information such as company profiles, contact information. Nicotine Gum Market Sales, Price, Revenue, Gross Margin and Market Share, Product Type and Applications, Regions, analysis is also carried out. What's more, the Global Nicotine Gum Market development trends and marketing channels are analysed.
No. of Report pages: 101
Price of Report: $ 3480 (Single User License)
Ask for Discount @ http://www.marketreportsworld.com/enquiry/request-discount/10241651
Table and Figures Covered in This Report:
· Table and Figure: Nicotine Gum Product Picture
· Table and Figure: Development of Nicotine Gum Manufacturing Technology
· Table and Figure: Manufacturing Process of Nicotine Gum
· Table and Figure: Company Nicotine Gum Product and Specifications
· Table and Figure: Company Nicotine Gum Product Capacity, Production, and Production Value etc. List
· Table and Table and Figure: Global Nicotine Gum Key Manufacturers Capacity Share List
· Table and Figure: Nicotine Gum Market Global Supply and Consumption
· Table and Figure: Import and Export of Nicotine Gum
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unconditional basic income turns the working world upside down! This shows the story of Manuela: She struggled with three jobs when she won basic income with us. Now she can confidently say no to adverse working conditions - and do the work she enjoys.
This public notice of Lien
It could be from the State Department or the Department of Treasury or another agency. It is usually a group and Congress and the president could be involved.
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From biodegradable glitter to SPF glitter sunscreen,...
3 brand new Fenty Beauty products are coming to the Middle East on April 6 –and we're SO ready!
Beat the heat in the Middle East with these beauty buys for all budgets and skin tones
I got it from my mama!
Nothing says I love you like a mother daughter manicure!
We're loving Bella Hadid, Rosie HW and Selena Gomez with bangs
Cheekbones never looked so good
The swag bag is worth a huge AED 400,000!!
Listen up if you're a '90s kid, butterfly clips are making a comeback!
Pastels are SO last spring, we're into neon's now!
The Gigi makeup is jetsetting to the Gulf!
Alexander Wang brings back the banana clip
Forget Kylie Jenner's baby girl, we're all about this baby news!
Where to find our beauty must-haves online in Dubai and UAE
Romantic shades for a romantic day...
A fearless liquid lipstick in fifteen shades
Your Valentine's makeup inspiration...
Dubai's newest hair salon by the iconic British hairdresser opens in February!
"Whether or not your hair is on display it doesn't affect how much you care about it"
Your body is a temple!
From microblading to makeup, here's where to get the perfect brows!
No it's not Halloween!
Renew your hair-do with curtain bangs…
We're still not over Selena Gomez!
Celebrating a Minority Within a Minority
Mermaid hair don't care!
Introducing the Mattemoiselle Plush Matte Lipstick Collection
Your new beauty inspiration according to Pinterest…
From Christmas gift sets to stocking fillers...
Deck the nails with glitter and holly
Straight from the weekend of celebrations
A magical evening with Dubai's best beauty influencers
How to show your love of the Emirates