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Placental Growth Factor
A Step Forward in the Search for a Treatment for Preeclampsia
See related article, pp 1263–1272
Preeclampsia, a pregnancy-related condition characterized by hypertension and proteinuria after 20 weeks of gestation, is an enormous global health problem. It is a major cause of maternal and neonatal morbidity and mortality and is closely linked to fetal growth retardation.1 Moreover, preeclampsia heralds an elevated risk of cardiovascular disease for both the mother and the baby in later life.2,3 Yet, despite the fact preeclampsia has been recognized as a serious health concern for millennia, we remain at a standstill when it comes to prevention and treatment of preeclampsia largely because of uncertainties regarding its pathogenesis. Accordingly, early delivery of the fetus and removal of the placenta remain the only recognized effective cure, which is of course undesirable for the child. Preeclampsia research is, therefore, of paramount importance.
In the current issue of Hypertension, the study by Makris et al4 takes a vital step toward confirming the potent angiogenic factor, placental growth factor (PlGF), as a suitable therapeutic target to combat preeclampsia. Certainly, extensive research during the past few decades has led to the recognition that maternal endothelial abnormalities underlie many of the clinical manifestations of preeclampsia. It is commonly thought that, as a result of poor vascularization during placental development, the inadequately perfused placenta releases vasoactive factors that subsequently enter the maternal circulation and damage the maternal endothelium.5 Moreover, recent advances in our understanding of the pathogenesis of preeclampsia have revealed that that an imbalance of angiogenic factors induced by the ischemic placenta may drive the pathogenesis of maternal endothelial dysfunction. Findings from both human and experimental animal studies indicate that the antiangiogenic protein, soluble fms-like tyrosine kinase 1 (sFLT-1), plays a key pathogenic role by binding and antagonizing the proangiogenic proteins, PlGF and vascular endothelial growth factor in the circulation, which are critical to the maintenance of the vascular endothelium (Figure).5 Maternal circulating levels of sFLT-1 are increased in women with preeclampsia,6,7 even before the onset of clinical symptoms, and correlate with the severity of the disease.6 Furthermore, increases in sFLT-1 are paralleled by decreases in circulating levels of PlGF and vascular endothelial growth factor.6,7 Although, in the experimental setting, administration of sFLT-1 to pregnant rats has been shown to induce hypertension, proteinuria, and glomerular endotheliosis.7 Accordingly, there is much interest in the notion that correcting the imbalance in the angiogenic axis may prove fruitful in treating preeclampsia and eliminate the need for premature delivery of the baby.
In particular, PlGF has recently become a large focus of preeclampsia research. It has been demonstrated that a reduction in circulating PlGF, as early as the first trimester, strongly correlates with the development of preeclampsia in women later in pregnancy.8 Moreover, investigations into the temporal relationship between maternal PlGF levels and placental perfusion in early pregnancy in humans have revealed that increases in PlGF correlate to increased placental perfusion.9 Such evidence gives credence to the theory that targeting this effector protein could correct the angiogenic imbalance in the setting of preeclampsia.
To investigate the potential therapeutic benefit of PlGF administration to restore angiogenic balance in the setting of preeclampsia, Makris et al4 utilized a nonhuman primate (baboon) model of uteroplacental ischemia, which demonstrates phenotypes analogous to that observed in preeclamptic women, including hypertension, proteinuria, and endotheliosis, as well as increased circulating sFLT-1 levels.4 The first key finding of their study was that induction of uteroplacental ischemia produced a decrease in circulating PlGF levels; thus providing direct evidence for a causal relationship between reduced placental perfusion and modulation of angiogenic balance in the clinical manifestation of disease. However, it was noted that PlGF levels rose back to baseline levels after 10 days of uteroplacental ischemia. The investigators attribute this to partial reperfusion of the ischemic placenta based on the observations of others that increases in PlGF correlate to increased placental perfusion.9
Remarkably, Makris et al4 also demonstrated that administration of recombinant human PlGF reduced arterial pressure and proteinuria and improved endotheliosis (as observed on renal biopsy) in their baboon model of preeclampsia (Figure). This provides strong evidence that targeting the angiogenic imbalance in preeclampsia by increasing PlGF levels can improve endothelial function. The dose of recombinant human PlGF administered was reportedly at the upper limit of what is considered the normal circulating PlGF range in uncomplicated pregnancy.
Notably, these findings extend the recent observations of several other research groups whom have investigated the outcomes of PlGF therapy on the clinical manifestations of preeclampsia in nonprimate experimental models. This includes a recently published in Hypertension, in which Spradley et al10 demonstrated the ability of recombinant human PlGF therapy to abolish placental ischemia–induced hypertension and improve renal function in rats.
Of course, the strength of the investigation by Makris et al4 is the use of a nonhuman primate model to interrogate the therapeutic effects of PlGF therapy on the clinical manifestations of preeclampsia. Animal studies are pivotal to the successful translation of scientific research from bench to bedside. This is particularly true in the case of pregnancy because there is a natural reticence to trial new therapies in human pregnancy. As such, the selection of an animal model relevant to the human condition of interest is of utmost importance. When it comes to pregnancy and preeclampsia research, studies in nonhuman primates represent an important translational link. As pointed out by Makris et al,4 although dissimilarities exist between human and nonhuman primates when it comes to the establishment of pregnancy including placenta pathology, mechanistic studies investigating the pathogenesis of preeclampsia in nonhuman primates offer advantages over other species (mice, rats, and sheep) that are commonly utilized in this field. For instance, the placenta is hemochorial and the implantation is essentially similar to that observed in humans. Furthermore, each pregnancy in a nonhuman primate typically involves a single fetus, and there is a similarity in the pattern of uterine blood flow between humans and nonhuman primates.
So, where do we go from here? Much work remains to be done. Although the findings of Makris et al4 provide new insights into the therapeutic potential of targeting PlGF to treat preeclampsia, at the same time they raise new questions that will require interrogation in future studies before such treatments could be introduced to the clinic. In particular, although this study investigated the effects of recombinant human PlGF on the mother, a limitation of the work was that fetal wellbeing was not assessed as an end point. However, any treatment given to the mother may affect the fetus. Another limitation of the model was this it was not possible to examine the impact of the treatment on the placenta because the mothers ingested this at the time of birth. It was noted by the investigators that all animals delivered at term and seemed normal on physical examination. However, a more thorough investigation is certainly required. It would also be of interest to follow-up the long-term outcomes of PlGF treatment on renal and cardiovascular health in the mum, as well as the offspring into adulthood, given that preeclampsia heralds an elevated risk of cardiovascular disease for both the mother and the baby in later life.
In summary, the findings of Makris et al4 add new insight to the growing body of evidence that targeting PlGF in the setting of preeclampsia may offer significant therapeutic benefit, at least in patients in which aberrations exist in the angiogenic axis. We now eagerly await the outcomes of further investigations in this field, with the hope that these new discoveries will lead to the implementation of therapies that can be used to safely treat preeclampsia in the clinic and minimize the need for preterm delivery.
The opinions expressed in this editorial are not necessarily those of the editors or of the American Heart Association.
- © 2016 American Heart Association, Inc.
- 1.↵
- 2.↵
- Heida KY,
- Franx A,
- van Rijn BB,
- Eijkemans MJ,
- Boer JM,
- Verschuren MW,
- Oudijk MA,
- Bots ML,
- van der Schouw YT
- 3.↵
- Cirillo PM,
- Cohn BA
- 4.↵
- Makris A,
- Yeung KR,
- Lim SM,
- Sunderland N,
- Heffernan S,
- Thompson JF,
- Iliopoulos J,
- Killingsworth MC,
- Yong J,
- Xu B,
- Ogle RF,
- Thadhani R,
- Karumanchi SA,
- Hennessy A
- 5.↵
- Gilbert JS,
- Ryan MJ,
- LaMarca BB,
- Sedeek M,
- Murphy SR,
- Granger JP
- 6.↵
- 7.↵
- Maynard SE,
- Min JY,
- Merchan J,
- Lim KH,
- Li J,
- Mondal S,
- Libermann TA,
- Morgan JP,
- Sellke FW,
- Stillman IE,
- Epstein FH,
- Sukhatme VP,
- Karumanchi SA
- 8.↵
- 9.↵
- 10.↵
- Spradley FT,
- Tan AY,
- Joo WS,
- Daniels G,
- Kussie P,
- Karumanchi SA,
- Granger JP
This Issue
Article Tools
- Placental Growth FactorLucinda M. Hilliard and Kate M. DentonHypertension. 2016;67:1114-1116, originally published April 18, 2016https://doi.org/10.1161/HYPERTENSIONAHA.116.07378
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Scene of the Week: Flash Gordon Football
While I would not classify myself as a football fan, there's no denying the impact that football, both professional and college, has had on American pop culture.
With the NFL season kicking off this week, we decided to celebrate with our first ever Gladiators of the Gridiron Week! A week devoted to football players turned action stars and movies that feature a football theme. What I am trying to say is it is going to be a regular Pigskinpalooza around here for the next 7 days!
I get to kick off this special week with a Scene of the Week from a true cult classic, Flash Gordon.
In the 1980 film Flash Gordon, our hero Flash Gordon (Sam J. Jones) is a well know football star from the New York Jets, who through a series of events finds himself on the distant planet of Mongo. Mongo is ruled by Ming the Merciless (Max Von Sydow). As his moniker implies, Ming is not a humanitarian and is looking to destroy planet Earth. So Flash and his new friends Dale Arden and Dr. Hans Zarkov (along with a killer Queen soundtrack) have the unenviable task of trying to defeat Ming and stop the destruction of their home planet in the process.
Our Scene of the Week showcases some of Flash's football skills as he goes up against Ming's minions. We even get some cheerleading action from Dale Arden!

subset: commoncrawl


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Question about Audio Players & Recorders
Suudenly, the home theater system seems to have lost the ability to produce colored images. All CDs are showing black n white images. I don't know what to do!
Posted by papai_99 on
I have spent a lot of money on compent cable and S cable. Instead of black and white high resolution picture, I now get navy blue and pink. If this cannot be fixed I will probably sell it. I have listened to all the Radio Shack experts and have spent nearly the cost of the entire unit on cables. Yellow is not hooked up..s and component and red/white to get sound..Please help.
I too am not getting any color in my home theater system. I have a Kawasaki HT1210 DVD Home Theater System. The color was working until today. I had to disconnect everything and reconnect and I wonder if I did something I shouldn't have. What is the progressive function listed? And where can I find it to see if it is activated? Thank you.
all dvd are in black and white
I have the same problem can you tell me where to look to see if its in the hdmi setting, i am using rca cables. As far as i know we hooked it up the same way before we moved and it was working and since we moved it we have no color.
Well, assuming were talking about a dvd player with dvd's,you dont specify what type of cables you are using to conect it to your tv, it appears that it has something to do with Progressive Scan been turned on. Progressive Scan is a feature built in your dvd player, wich by using it, it would give you a better picture//resolution on your tv, you need to use Component or HDMI cables to hook up the dvd to your tv if you want this settings, but if you are using composite RCA cables (Red,White & Yellow) and the Progressive funtion is turned on by accident, it may give you a split screen, black & white, or no picture problems. Also if you are using Component (Blue, Green & Red) cables, if one of them is unplug, the picture can be out of colors, or no picture. Check this things, if not, write back with more details about your set up.
Posted on May 23, 2008
SOURCE: I have freestanding Series 8 dishwasher. Lately during the filling cycle water hammer is occurring. How can this be resolved
A 6ya expert can help you resolve that issue over the phone in a minute or two.
Best thing about this new service is that you are never placed on hold and get to talk to real repairmen in the US.
The service is completely free and covers almost anything you can think of (from cars to computers, handyman, and even drones).
click here to download the app (for users in the US for now) and get all the help you need.
Good luck!
Posted on Jan 02, 2017
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Coping with Divorce Hypnotherapy could help your child.
I could not begin to count how many adult clients I see whose problems began when their parents divorced. It really doesn't matter how long ago the event was or how old the client may be, if the divorce was messy and destructive the child suffered.
I have worked not only in the North East of England but also many other countries around the world. In every country I have seen children whose parents have divorced or who are going through a divorce. I can help these children to cope with the stress and misplaced guilt that they often experience .
Children need to feel from their parents a sense of security and safety. Children don't need to know their parents' every woe and trouble or how angry and upset they are, how much they hate the other parent. Through the natural course of development children will come to know their parents as adults, as human beings. They don't need it in their early lives as a Psychologist I can tell you it is extremely harmful.
Witnessing a parent in distress can destroy your child
Unfortunately it's rarely possible for parents to divorce without some anger and stress becoming clear and obvious to children. However, many of the children have seen have endured weeks, months, even years of fights, crying, anger and more.
When children are trying to cope with strong emotions of their own it doesn't help Seeing their parents feeling negative emotions this only serves to scare and upset them even more. Unfortunately, the child will often put their own feelings to one side so that they can become their parent's carer. It should never be the role of the child to have to help the parents through the emotional traumas of divorce.
How can hypnotherapy help?
Using Hypnotherapy I help the child to cope with strong emotions, to be able to manage them more calmly and to see the divorce as not their fault and to see the positive outcomes.
Visit me at my Gateshead consulting rooms or home visits across the North East of England.
1 to 1 sessions are also available by Skype
Availability and prices:
Home visits – Hypnotherapy
Hypnotherapy Home visits are available across the North East of England, From Morpeth and Ashington in the North to Middlesbrough and Darlington in the South. From Whitley Bay in the East to Hexham and Corbridge in the West
NE1 – NE21 £80, NE22 – NE42 £90, SR1 – SR6 £90, NE43, SR7 – SR9 £110, DH1 – DH99 £130, All TS & DL postcode areas £180
Gateshead Consulting Room, Rydal Street, Gateshead. (Behind Coatsworth road)
Counselling £45 per session
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Tel Landline
0191 440 8649 & 0191 645 50 60
or Mobile 07596 673319
The cost for Skype Hypnotherapy is £65:00
All therapies now available as MP3 Download at affordable prices, click here for details.
Have a Question? Complete the inquiry form for a speedy and confidential response.


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This hooded rain jacket will be big for spring.
It's officially warm enough to wear an anorak! The big pockets are perfect for carrying around a Penguin classic at all times. Best worn with fringy haircuts and pastel colors.
Editorial note: Whoa! You've found a super-old post here on BuzzFeed, from an earlier era of the site. It doesn't really represent where we are anymore, and may in fact be totally broken, but we're leaving it up as a part of our early history.
Preview Your Response
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Workers in Edo resume after public holiday in honour of Late Dr. Ogbemudia – Independent Television and Radio
Independent Television and Radio
Workers in Edo resume after public holiday in honour of Late Dr. Ogbemudia
Independent Television and Radio
Workers on Monday resumed work after the one day public holiday declared by Edo State Government in honour of Late former Elder Statesman, Doctor Samuel Ogbemudia. Best Mbiere who went round some ministries reports that some workers in Edo State …
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IT staff development and retention
IT staff development and retention planning is critical for CIOs trying to successfully compete in this global market. Some retention incentives CIOs should consider include time off, stock options, flex time, pay increases and more. Find the latest IT staff development and retention information and advice for CIOs, including IT staffing news, tips and other resources, here in this topic section.
New & Notable
PDF: What does "digital transformation" really mean?
What exactly is digital transformation? You may hear the term often, but everyone seems to have a different definition. See how our experts define digitization, and how you can get started in this free guide.
By submitting your personal information, you agree that TechTarget and its partners may contact you regarding relevant content, products and special offers.
You also agree that your personal information may be transferred and processed in the United States, and that you have read and agree to the Terms of Use and the Privacy Policy.
IT staff development and retention News
April 11, 2018
Computer vision, machine learning skills help fuel surge in AI jobs
A report by the world's No. 1 job site, Indeed, finds there are more AI jobs than ever, but job-seeker interest is leveling out. What accounts for the dwindling enthusiasm among job hunters?
February 05, 2018
Critical elements CIOs need to build an AI team
Top-notch recruiters, organizational structures that engender trust, and attention to ethics are key to ensuring your AI team succeeds.
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Customer success managers: Guides to client happiness
Customer success managers help clients define success -- then they help them get there, according to a software vendor employee who has the title.
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A new report by jobs site Indeed shows skills in JavaScript library React are becoming critical to land jobs. Also important is cloud computing know-how.
IT staff development and retention Get Started
Bring yourself up to speed with our introductory content
Forrester: The CIO's job in fostering human-machine collaboration
According to a new Forrester report, more human-machine collaboration in the enterprise can lead to a simpler, more productive -- and more human -- workplace. IT has a special role to play. Continue Reading
Biofeedback is a system that monitors biological data from users and trains them to improve their physiological responses, with the goal of improving physical and mental health and performance. Continue Reading
transformative technology
Transformative technology is hardware- and software-based tools designed to enhance human psychological well-being, cognitive function and physical capabilities. Continue Reading
Evaluate IT staff development and retention Vendors & Products
Weigh the pros and cons of technologies, products and projects you are considering.
Social media key to future of learning and development
Employees aren't just wasting time on social media; some are learning the career skills that will take them to the next level. Here's why that matters to your organization. Continue Reading
HubSpot CPO shares HR technology strategy wisdom
For marketing software company HubSpot, HR technology decisions are led by strategy and employee experience, not by shiny object syndrome. Here's a look. Continue Reading
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If you think a corporate wellness program begins and ends with giving employees a Fitbit, it's time to do some homework on the next-generation of health promotion programs. Continue Reading
Manage IT staff development and retention
Learn to apply best practices and optimize your operations.
Four trends shaping the future of the HR profession
As power increasingly shifts to candidates, the HR tech landscape explodes and the economy improves, HR professionals are being forced to reinvent their roles. Continue Reading
Why you need a brand-new corporate learning strategy
Employees are getting more and more difficult to retain. That's why learning and development programs are so critical. Here's how to update yours. Continue Reading
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Expert Gerie Owen discusses the differences between a startup culture and an established company's work environment. Learn more about which would work best for you. Continue Reading
Problem Solve IT staff development and retention Issues
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Enterprise digitization's secret ingredient: Fusion teams
Cross-functional or 'fusion' teams are critical to meeting fast-changing digital challenges. Here are the four must-have team attributes for successful enterprise digitization. Continue Reading
HR plays to win with gamification for learning
At some companies, corporate education has become a tool for engagement and employee experience. See how gamification is putting the 'fun' in learning fundamentals. Continue Reading
Secrets of winning at your employee experience strategy
Marketing software company HubSpot has landed on numerous best places to work lists, but press about its workplace hasn't been all rosy. CPO Katie Burke shares thoughts on both. Continue Reading


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MCAS NEW RIVER, N.C. — "Help," cried a stranger moments after running a small child over with his truck.
No verbal answer came … only action.
The child's father sprinted from his house and through his yard to assess the situation. He saw something no father wants to see – his four-year-old son lying on the pavement without a pulse and not breathing.
His wife, 18-weeks pregnant, was on her knees, crying and screaming for him to not let her baby die.
He administered two breaths, checked for a pulse, gave chest compressions and then more rescue breaths. Emergency Medical Services arrived to find the child breathing.
At the hospital, his wife put her arms around him. She thanked him for saving her child.
For his actions, the Red Cross awarded Gunnery Sgt. Shawn D. Angell a Certificate of Merit during an award ceremony at the Rotary Community Center in Bluffton, S.C., Aug. 21.
"The award is a very big deal," said Mike Kelley, Red Cross Health and Safety Services director. "Our whole mission at the Red Cross is to save lives. Our motto is, 'Together we can save a life.' It's all about sustaining and saving lives. It's very important we recognize individuals for that."
Angell was able to save his son because of all the training he received when he was a water survival instructor and a drill instructor. The Red Cross recognized him because he volunteered his time with the Red Cross and is also as a certified Red Cross life guard.
"I was an instructor at Parris Island teaching all of this," said Angell. "I was in charge of teaching all of the Marines life-saving skills and cardiopulmonary resuscitation and was the noncommissioned officer-in-charge of the pool deck. I ensured all life-saving skills were on key, so when it came time to useit on my son it was second nature."Personally I don't think it is that big of a deal. (The award) isn't for
glory," added Angell, who is currently the Marine Heli-copter Training Squadron 302 maintenance control room NCOIC. "I'm just glad he is alive."Timothy is fine now. Angell said he doesn't
care about the award. He is just glad that his son is alive. He just did what any other father, Marine or drill instructor would have done in that situation.


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Salted, Cured and Smoked Salmon
Established in 1979, Njardar became a joint stock company (AS) in 1995. The company is ideally situated on the west coast of Norway, near one of the best fishing grounds for cod, herring and mackerel. Njardar AS specializes in the production of salted herring and mackerel, smoked herring and mackerel, herring products and clipfish (dried, salted cod).
Njardar AS
Leinevegen 17, 6094 Leinøy
Tlf.: +47 70 08 66 86
E-post: email@example.com
Jan Agnar Nærø – CEO
+47 908 61 017
Email: firstname.lastname@example.com


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California dating married rosa santa woman
This ensures you meet real, local singles that are compatible for dating.
As we like to say, "Isn't it time to live, laugh and love again? If there was the option to give it no stars I would have.
is the premier resource guide to local dating scene for singles on the go in search of Santa Rosa singles groups, events and activities.The town of Sebastopol formed in the 1850s with a U. Post Office and as a small trade center for the farmers of the surrounding agricultural region.As California's population swelled after the westward migration to the long British siege of the seaport of Sevastopol (1854-1855) during the Crimean War of 1853-1856.It is about a 20-minute drive from the Pacific Ocean, between Santa Rosa and Bodega Bay, and is known for its liberal politics and small-town charm.It was once primarily a plum and apple growing region; wine grapes, however, are now predominant, and nearly all lands once used for orchards are now vineyards.


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Straight Distance
Driving Distance
Estimated Driving Time
The straight distance between Creston, LA and Thornton, KY is , but the driving distance is .
It takes to go from Creston, Louisiana to Thornton, Kentucky.
Latitude: 31.976 // Latitude: -93.0499
We're sorry but Creston, LA weather is not available right now.
Latitude: 37.1729 // Latitude: -82.7776
We are sorry, but Thornton, KY weather is not available right now.


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Street Beat: Women's History MonthOn this edition of Street Beat, April Moss talks with the Michigan Women's Historical Center and Hall of Fame, the Michigan Women's Foundation, Inforum Southeast Regional Council, and the National Congress of Black Women, Oakland Chapter to talk about Women's History Month.
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I'd almost finished this post. I had a few more sentences to go, then I was going to proofread and publish. But then I had to go and click some random button. Seemingly harmless, yet when I returned to my post, it wasn't there.
So, please take my advice, and don't go pushing mysterious buttons when posting on WordPress! Let's try this again.
The Barbie Toga
Size 10 Crochet Thread
Size D (3.25 MM) crochet hook
Scissors & Yarn needle
The Pattern
Ch 50. Join with a slip stitch to the first chain to form a ring, being careful not to twist chain.
Round 1: Ch 1, sc in each st around, sl st to join.
Round 2: Ch 1. Sc 15, skip 10 sts (which forms the strap), sc 15 more, sk the last 10 sts. Sl st to join.
Rounds 3-10: Ch 1, sc in each st around, sl st to join.
Round 11: *Sc 4, sc2tog* around.
Do not fasten off.
Now we're going to extend the toga by working half-double crochets in rows.
Ch 20. Hdc 19 starting in 2nd ch from hk. Now you have this long flap hanging from the toga top. We need to attach it to the top with two slip stitches.
You have a bunch of unworked stitches from Round 11. Find the first unworked stitch and slip stitch into it. Then slip stitch 1 more into the next stitch.
The slip stitches count as your turning chain. Now turn the work, and half-double crochet across.
You should be at the end of the row without the slip stitches. Chain 2 and turn. Now hdc in each st across.
Repeat this method (2 joining slip stitches, turn, hdc across, ch 2, turn, hdc across) until you're all the way around. I added 4 extra rows to make it flowy-er by slip stitching in the same space more than once, when there weren't any unworked stitches left. This is optional.
Tip: When doing the slip stitches and turning, it can be hard to see where to put the first hdc. When you are about to slip stitch, try putting a stitch marker into the last hdc. Then, when you turn it, you'll be able to see where to go.
Now turn the toga inside out. Join the hdc rows by slip stitching across through both layers. Turn the toga right-side out, and fasten off.
The toga top will be kind of baggy. I decided to cinch it up a bit, but you can leave it baggy if you like. I wove some thread across the front (between the straps) and cinched it. Weave in all of your loose ends, and you're done!
I hope you like the pattern!
~ The Cogaroo ~


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Like her husband's policies, Melania Trump's style remains hard to pin down. After a wide-ranging wardrobe from her first couple days in Germany at the G20 Summit, the FLOTUS threw us another curve ball with a white, tiered and fringed Michael Kors dress for a concert on Friday night. She coordinated the look with a pair of sky-high white Christian Louboutins for a look that was downright festive. Perhaps, the whimsical, vintage-feeling, and fun-loving dress was a distraction from the speculation and the protests that have followed the Trumps on their visit. The bold party dress certainly turns heads.
Either way, it's a style move we weren't expecting from Melania, making her First Lady style as unpredictable as the current administration. Take a closer look at the flapper-inspired look here.
via POPSUGAR Fashion http://ift.tt/2tBOeAs


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This article was printed from mlb, originally published .
Read more news at: https://www.mlb.com/news
Quisenberry part of Hall's Expansion Era ballot
KANSAS CITY -- Dan Quisenberry is in the Royals Hall of Fame, and now he's getting another chance at the National Baseball Hall of Fame and Museum in Cooperstown, N.Y.
Quisenberry is among 12 candidates to be considered by the 16-member Expansion Era electorate at the Winter Meetings at Orlando, Fla. Results of the vote will be announced on Dec. 9.
A closer with a submarine-style delivery, Quisenberry had 244 saves in his 12-year Major League career, 10 of them with Kansas City. He finished in the top five in Cy Young Award voting five times, made three All-Star teams and led the American League in saves in five seasons.
In 674 relief appearances, Quisenberry also had a 56-46 record and a 2.76 ERA. He died of cancer on Sept. 30, 1998.
Also nominated were players Davey Concepcion, Steve Garvey, Tommy John, Dave Parker and Ted Simmons, managers Bobby Cox, Tony La Russa, Billy Martin and Joe Torre, union executive Marvin Miller and Yankees owner George Steinbrenner.
Any candidate who earns 75 percent of the ballots cast by the committee will be inducted at Cooperstown on July 27, 2014. The 16-member committee includes former Royals manager and Hall of Famer Whitey Herzog.
This is the second election by the Expansion Era committee which, in 2010, elected long-time executive Pat Gillick. This is Quisenberry's first appearance on the ballot, which considers candidates whose most significant impact was from 1973 through the present.
Quisenberry, with the Royals from 1979-88, was noted for his command, his unusual delivery and his quick wit. He earned 238 saves in his 573 games in a KC uniform. He was on the Royals' only two World Series teams in 1980 and 1985.
In his first turn on the general ballot by Hall of Fame electors in the Baseball Writers' Association of America, Quisenberry did not receive enough votes to remain on future ballots. He was elected to the Royals Hall of Fame in 1998.


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Lots of people want to ride with you in the limo, but what you want is someone who will take the bus with you when the limo breaks down. - Oprah Winfrey
How true :). I had a wonderful evening/night with Geri the Bun and my awesome friends who I'm sure are willing to take the bus with me :P.
Also, I actually found the RMIT event pretty enjoyable, although I was only involved in like 0.0001% of it. For some reason the way the students behave made me smile, even though I usually dislike noise. I think it's because it reminds me of my polytechnic days, something I can never dream of seeing in my own school, very sadly.
Geri is an awesome speaker :P! I'm so proud of my Bun! Haha :D. Words can't describe how awesome she is to me ^^.
On another note, I watched Cloudy with a Chance of Meatballs with Geri yesterday. It's a VERY good show :). I think it's especially true that sometimes we find it very hard to express what we really feel, and end up using corny words, or worse, hurtful words, when what we really want to say is, "I care. Please be fine." With that said, I think it's better that we are this way, instead of the crap I hear in life sometimes, like "You're the best, bro." every single time they meet, or some other similar crap, you know what I mean. On the other hand, of course it's good to speak your mind/heart more often :). Just don't be a wanna-be :P.
I accept the very sad fact that I don't like my school life. You know it sucks when I like my modules more than some of the people I know :). Not like it matters a lot to me anymore. Some things just aren't worth your time. Don't even bother to try and understand. If people like to cause pain and drama for themselves, why should you care?
Also, I was a partial fashion disaster today. I've learnt my lesson not to mix stripes with checkers :P, although I still think it looked pretty ok *beams with pride*. Thanks for the advice though :D.
With regards to my midterm, I shall work harder :).


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Valentino Sunglasses, Maison Jules Blouse, Macy's Shorts & Belt, Zara Heels, Loeffler Randall Bag, MK Watch, BaubleBar Cuff, ASOS Rings
I don't wear monochromatic looks too often. But a classic blue color is one that I can get on board with. Especially when it (unintentionally) has an ombre effect. I also took these pictures on my college campus while I was there to see Jersey Boys on tour. It has only been a year since I have been there, but there are a lot of changes from the last time I stepped foot on campus. It was interesting to see the school in a different way; I didn't have to race through to get to a class. I could just simply enjoy it's splendor with the interesting buildings, sitting areas, and reminisce over memories from the school.


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Skye Rhodes is a normal teenage who just wants to live life smoothly, until her parents arranges a marriage. Forced to marry a jerk from her school, Skye needs to stop her wedding from her parents forcing her to marry Landon, her future husband.
- arranged
- arrangedmarrage
- arrangedmarriage
- drama
- friends
- help
- issue
- japan
- love
- marriage
- pray
- sad
- school
- teen
- teenfiction
- upload
xpotatomalfoy_ Feb 24
get spoiled and black mail him if he doesn't do anything i want :3
Loveanime458 4 days ago
Honey, I know you think he sucks but at least you had a boyfriend
alondra1013 Mar 14
I would put with it because I'm a bigger jerk and i would tell him that I'll i wont act like one if he buys all the new tech that's coming out in the future
ShimmyShimmyAy Feb 24
Tell him that as long as I can meet Shawn Mendes I wont bother him! AND Tom Holland and Theo James and the dolan and sprouse twins OH and James and Dave Franco and CHRIS EVANS!!!Also take me to all the mvoei premieres I want otherwise I WILL MAKE UR LIFE A LIVING HELL <3
Kawaii_Kitsune Mar 04
Whenever I read or hear the name Layla, I immediately think "LAYLA HEARTFILIA" (when you need a life)
Pleasenobodynoticeme Mar 12
Oh my god, I'm not crying, it's just dust in my eyes (Darcy was a great friend of mine, I liked him a lot [Platonically] and we loved playing games with each other, then we lost contact after Primary school, now that I realise, he was kinda a jerk...)


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Make an Offer!
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Savannah, a coastal Georgia city, is separated from South Carolina by the Savannah River. It's known for its manicured parks, horse-drawn carriages and ornate antebellum architecture. Its cobblestoned historic district is filled with squares and parks like Forsyth Park, shaded by magnolia blossoms and oak trees covered with Spanish moss. The historic district's architectural landmarks include the Gothic-Revival Cathedral of Saint John the Baptist. Call 678.770.5046 for all your Real Estate needs.
One visit to Savannah and you'll be hooked, so why not buy a Savannah home now and enjoy all things Savannah, like the Telfair Museum and Fort James Jackson. And for the more adventurous and those thrill seeker, why not check out the Bonaventure Cemetery, (we dare you to). Be sure to check out the Savannah beaches, restaurants and all the attractions that Savannah has to offer.


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4 Major Beauty Blunders That May Be Damaging Most Women's Hair, Nails, Skin, Lungs, and Brains
However, there are some risks taken with daily regimens or certain styles that most people aren't even aware of. Many don't know that they're risking their health with a bit of blush or a particular shampoo.
4 Beauty Mistakes You Should Never Make Again
Here are four mistakes you weren't aware of but should not make again.
1. For the Love of Locks, Your Hair Can't Take It
Hair is a wonderful accessory that can change your overall look. From different styles to different colors, our hair plays a key role in our beauty regimen. But changing the color of our hair isn't as easy as those commercials make it seem.
Using various hair dye products can result in an allergic reaction (like a rash or burning sensation), various cancers (including breast, bone marrow, and lymph tissue) and also asthma from breathing in the chemicals. [1]
And it's not just the hair dye; hairsprays and gels are also made up of toxic ingredients that make similar to insect repellants, flammable gas and furniture finishers.
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DIY Natural Hair Dye
Instead of traditional and harsh chemical dyes, you can use teas (like chamomile) to make your hair either blond or red and coffee if you want a darker shade. You can also try a naturally made henna dye. Honey and cinnamon will also lighten your hair if that's the look you want.
2. Strong Beautiful Nails Mask Internal Weakness
One way to relax and feel pampered is to get a manicure. In the end, you have gorgeous nails that are like body jewelry. But the price for these decorations is higher than you know. Probably just from the smell of nail polish or remover, you can tell it's not meant to be inhaled.
Breathing in those harsh fumes can lead to neurological or development issues and allergic reactions. But that's not the only way the chemicals can affect you. The glues used holding acrylic nails in place can lead to a spreadable infection in your nail beds. [2] Also, some nail polishes contain toluene, a chemical known to cause reproductive issues. [3]
Non-Toxic Alternatives
There are many great alternatives to these toxic topcoats including brands like Piggy Paint (excellent and kid-friendly) and Acquarella, which is water-based. If you still want to keep the base coat and top coat set-up, there's also Scotch Naturals.
Have brittle nails? Check how Coconut Oil can help your brittle nails!
3. Your Skin Isn't Too Sensitive; Your Products are Damaging
Our skin is something that we have to take care of, particularly since part of a beauty routine. One thing most of us can relate to is having dry skin (especially in the winter months) and using lotion regularly. Scented Moisturizing lotions can leave a nice fragrance on you. However, they can also cause rashes and irritation.
Rubbing in certain moisturizers, facial or other skin creams has shown to cause tumor growths. Most of them contain mineral oil, which helps make the products loose but is also a derivative of petroleum aka the gas for your car.
When you put these products on your skin, they get absorbed through the thin layers and aren't filtered. As a result, they can be extremely harmful.
Safe and Natural Skin Care Alternatives
Instead of slathering on the toxic stuff, why not try some natural alternatives that give the same great benefits of moisturized, healthy-looking skin without all the harsh effects?
- One of the best moisturizers is coconut oil. It has a pleasant scent and will also minimize imperfections like scars or cellulite.
- You can also try aloe vera gel (great for sun-damaged skin), olive oil (yes, the same one in your kitchen) or rose water.
4. Makeup Gone Wrong
Because makeup goes on our skin, we are still at risk for a host of negative effects. One of the obvious side effects is clogged pores. When you cover your skin with foundation or powder, you're suffocating it and this causes irritation. Certain mascaras and eyeliners contain a preservative known as thimerosal, which can cause conjunctivitis (pink eye). [4]
Parabens are one of the most dangerous substances found in makeup and can be found in a variety of different products. It's a preservative, so it helps extend the shelf life of your makeup while exposing you to short-term and long-term aftereffects.
There are even some chemicals in your makeup kit that can alter your hormones just by getting into your skin. A safer option to all of this is to make your own makeup.
DIY Makeup
Using cocoa powder, arrowroot powder or mica powder, you can create a natural foundation. Making eye shadow can also be done with cocoa powder. With a little research and a few ingredients, you can create the same looks without risking exposure.
Here are a few more natural DIY beauty recipes to give a try!
[1] American Cancer Association. (n.d.). Hair Dyes. Retrieved from http://www.cancer.org/cancer/cancercauses/othercarcinogens/intheworkplace/hair-dyes
[2] Nail Doctors. (n.d.). What is nail fungus? Retrieved from http://www.naildoctors.com/nail_fungus.html
[3] Agency for Toxic Substances and Disease Registry. (2015, January 21). Toxic Substances Portal – Toluene. Retrieved from https://www.atsdr.cdc.gov/phs/phs.asp?id=159&tid=29
[4] Mondino, B. J., Salamon, S. M., & Zaidman, G. W. (1982, May/June). Allergic and toxic reactions of soft contact lens wearers. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/6810487
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A Quick Note from Our Founder
Did you know Bacon & Butter may help burn fat like crazy??
Have you heard of the Ketogenic diet? Going "Keto" has helped so many of my friends drop weight and keep it off.
And it's the perfect time to try it because right now you can get a free copy of a brand new cookbook called Bacon and Butter: The Ultimate Ketogenic Diet Cookbook.
This cookbook is jampacked with 148 delicious ketogenic recipes that will help you burn fat like crazy. Even stubborn belly and thigh fat won't stand a chance because your body will have NO CHOICE but to burn that fat for fuel!
If you've struggled to get rid of stubborn fat, you owe it to yourself to test-drive the keto diet and see how effective it really is. It'll be easy once you have this free cookbook…
HURRY, this FREE offer won't last long!
Sasha Brown
You connect with Sasha here!
Latest posts by Sasha Brown (see all)
- 12 Powerful Spices That Will Help Treat 6 Common Health Problems - April 10, 2017
- Prep this dessert in just minutes – honey-cinnamon pears that will melt in your mouth - March 10, 2017
- 10 Simple and Discreet Desk Exercises for Lower Back Pain - February 24, 2017


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Mashed in the Potatoes by Lesley A. Diehl
by Barb Goffman
From the anthology The Killer Wore Cranberry: A Second Helping (Untreed Reads Publishing, 2012).
It's Thanksgiving again, and Aunt Nozzie has commanded that her niece Darcie attend dinner. Darcie's family is filled with women. The men always die off young or – when they marry in – quickly. This year, Aunt Nozzie has demanded that everyone bring dates so there will be some testosterone at the dinner. Given that Aunt Nozzie's Thanksgiving dinners are typically chaotic, this addition certainly bodes well.


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The Favorite for the US Open? I Take Roger Federer!
by TEZZA JACOPO | VIEW 11014
Jacopo Tezza (on top) is the director of the Evert Tennis Academy in Boca Raton.
Originally from Italy, Jacopo has coached both at the University of Central Florida and the Texas Christian University, before becoming director of the academy founded by the Evert Family in collaboration with IMG.
Currently working with World No.103 Olivia Rogowska, Jacopo collaborated with futre WTA stars such as Madison Keys, Lauren Davis, Maria Sanchez.
http://www.evertacademy.com/ With this piece Jacopo joins the team of Tennis World USA.
He will share with us his expertise and impressions on the world of tennis.
There Were Once the Fab Four by Jacopo Tezza It has been another great year of tennis, full of great matches and drama.
Once again it was Nadal domination on the red clay at the Roland Garros, and after one of the greatest matches of the year, Djokovic beat Federer for the Wimbledon glory. The hard court season is now fast approaching and with that, a whole new thrill of who will win the last Grand Slam of the year.
Although Nadal, Djokovic and Federer have dominated the tennis scene in recent years, going into the US Open next month, I believe we may see a different face stepping up to the occasion. The Big 3 (Nadal, Djokovic and Federer) remain as such, but I think the gap is closing, as there are several younger players that have proven themselves in past seasons as worthy opponents, and seem "almost" ready to take the scene away from them.
Djokovic seems to have found his 2013's mojo where for the first part of the year he was unbeatable. He recently got married and Boris Becker seems to have given him the necessary confidence to perform at his best in the clutch moments.
I like Federer's chances in New York personally. The courts are fast and suit his aggressive skills extremely well. It seems he has found a great level of comfort with his new racket and new aggressive strategy thanks also to Stefan Edberg.
I would really like him to bring out the serve-and-volley often. I believe keeping an aggressive mind set is essential for Roger to make a run to the title. You can never count Nadal out either. He is a natural competitor and I'm sure he is hungry to regain the number one spot, but even hungrier to get one Slam closer to Federer.
With some adjustments, Nadal has proven his game to be successful on the hard courts. He's adjusted his game by playing closer to the baseline, serving bigger and taking the ball earlier. The wrist injury has however happened in the worst possible moment, undermining Nadal's chances to have a proper preparation for the US Open.
So, who's going to step up to face these guys? The list is longer than it has ever been with Murray, Dimitrov, Raonic, Wawrinka, Berdych and Nishikori etc. The draw will play an important factor for whoever will be in the final.
I think any of these players have the potential to defeat the Big 3, but their chances can improve based on the match ups. Despite the match ups, Dimitrov seems to be the one taking over Murray's spot.
He has already put few ATP titles under his belt, his game has been extremely successful and has caught the Big 3's attention.
Dimitrov challenged Djokovic almost to the limit in the semifinal at Wimbledon, and it is possible that Dimitrov will play even better on the fast courts at Flushing Meadows. Although younger than all the Big 3 players, Dimitrov has already reached a semifinal in a Grand Slam and has matured tremendously as the season progressed.
He seems to have learned how to use his talents which have greatly elevated his game. No matter your favorite, we'll all be watching to see whether Federer will add an 18th major to his sterling career, if Djokovic or Nadal will close the gap with Federer in majors won, or maybe it's time for a newcomer to own the title.
I do expect another "familiar" final with 2 of the Big 3 in the final, but this new generation of players is pushing for more ground and the gap is closing. If I were to pick a favorite, I would go with Federer, with a minimal advantage over Djokovic.


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"Good fences make good neighbors." an immortal line from Robert Frost's poem Mending Wall may be among the most well-known proverbs about boundaries and is an excellent metaphor for healthy boundaries. Well made physical walls allow for drainage, air flow, they are built to flex as needed in order to serve their purpose, make clear limits. In some cases these walls take on a glorious patina of lichen, small plants, moss or vines. They become "naturalized" integral parts of the landscape. In other words they are inviting and welcoming while establishing clear boundaries. That is your aim too in setting personal boundaries.
Expecting others to and asking them to treat you appropriately is fundamental to your quality of life, your well-being and maintaining a positive self-image. Establishing flexible healthy boundaries and maintaining them are vital to take responsibility for yourself, your life.
Personal boundaries are like imaginary fences created to protect your body mind and spirit. They establish your limits and expectations for how other people will interact with you and indicate how you will interact with them. Boundaries can be mental/emotional or physical. Emotional boundaries demarcate where your feelings end and where those of another person begin. Physical boundaries define who can touch you, in what way and when you can be touched. They also govern your personal space, how close someone can physically approach you.
Healthy personal boundaries protect you from the unhealthy or damaging behaviors of others. They do not shut out everyone and everything but rather indicate what you expect and will permit. Healthy boundaries are flexible. Leaving some room to raise or lower the height of your personal boundaries, to adjust as needed allows you to fully experience life and maintain responsibility for your happiness. With healthy boundaries you are assertive as needed while respecting the needs, feelings, rights and opinions of others. You give and receive support. You are comfortable with yourself, and make others comfortable too. You do not let in people who do not make you uncomfortable or do not respect your boundaries.
Unhealthy boundaries can be too loose or rigid. Loose boundaries can result in expecting others to read your mind, or feeling responsible for other people's feelings, or putting your hands on strangers. Boundaries that are too loose in the extreme are non-existent. Rigid boundaries can lead to literally shutting out all other people in your life.
Click here for 7 Essential Steps in Setting Health Boundaries.


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CROSS-COUNTRY: Highlanders motivated by lackluster state finish
Published 12:00 pm, Wednesday, August 20, 2014
Motivated by a string of injuries and a less-than-desirable finish at the state meet last year, The Woodlands has been working hard this offseason to storm back and claim supremacy over the local cross-country scene.
Coach Juris Green knows his team will be facing quite the challenge at the district, regional and state levels, but with the proud tradition of Highlanders' program lingering through the school's athletic halls, this year's expectations will not be tapered.
"Our expectations are high — they always are," Green said. "They're maybe higher than some people around us think they should be, but we have always, historically, over-produced at times when people didn't think we could."
Junior Michael Butero is the top returner for The Woodlands after finishing ninth at the District 14-5A meet and 11th at the Region II-5A meet last season. He returns alongside Matt Henderson, who took 16th at the district meet. Seniors Eric Kroon and Javier Arana, who won the junior varsity district title last year, will also be called upon to contribute.
"We're obviously looking to win a state title this year," Kroon said. "The last few years we haven't done so well, but this year we feel good about our team. We're going to try to win state and then earn a trip to [Nike] Nationals later on."
Others vying for varsity spots include juniors Matt McClellan, Nick Hawley and Daniel Golden, who all posted top-seven finishes at the junior varsity district meet last season. Sophomores Noah Wells and William Hansdale will also provide competition.
"I think what we're looking forward to most is just some redemption and getting back on an even keel," Green said. "We had a good season last year, but it just didn't end like we wanted it to, and it's given us enough drive to come back."
The Highlanders finished seventh at the UIL State Championships in 2013 without their top runner, Logan Emery, who is now at the University of Texas at Austin. Butero was the top finisher for The Woodlands at 49th, while Henderson took 62nd.
"Last year, a lot of people got injured, and we weren't running the team that we were hoping to run," Kroon said. "But this year, everybody's managed to stay healthy so far — knock on wood. Last year was really disappointing, so this year, we've got a lot of motivation to come out on top."
Competing even at the district level is always tough with College Park, Oak Ridge and Conroe challenging, but with the new District 16-6A in place, the Highlanders will also welcome competition from the likes of Kingwood, Atascocita and Summer Creek.
"Kingwood's always pretty good, and Atascocita, they're not bad, also," Kroon said. "But the big challenge will be College Park being in our district and all the way through state. It will be good practice because they'll be one of our main competitors at state. It will be tough to race against them, but we'll be good.
Added Butero: "We are fortunate to race against such good teams because it makes us better and it motivates us to do better as a team."
Jon Poorman is the sports editor at The Villager and covers The Woodlands area for The Courier of Montgomery County. Follow @WoodlandsSports on Twitter for all the latest community sports news.


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Personal life
I gotta tell you, this healthy living stuff is for the birds. I have been having real success with the combination of modern medicine, a kitchen scale, an app and a messenger support group (I am not even kidding there). So far I am a month and a half in and I love most of it. I have lost 20 pounds on the Phentermine combined with light workout and food changes. Your health class in school does not prepare you, though, for the idea of good and bad fats. Then there's portion control! If my husband and I go out there's my sodium for the day! Even if I am trying to be good! Lastly, if I have to crawl to the gym at 3:30 in the morning I should look like a swimsuit model- just saying!
It isn't all bad though. I am proud of my weight loss even if I can't physically see any changes. My energy levels are still fairly low, which stinks because that was the main reason I wanted the pill. I can get through everything, though, and am not as tired so there's a plus. The Myfitness pal has been a tremendous help with counting calories and nutrients and my buds have been super supportive. I can touch my toes!!!!! Plus, under the plan my fitness pal has me on, I firmly believe I could do this for the rest of my life without my pill. That's what I want! I won't loose as fast, but I will be able to do it all on my own. I do worry about cravings (I will still cut a bitch for a French fry), but I think I can handle it.
Bookish Life:
Goodreads has let me know I am five books behind on my goal of 150- I may not make it this year and I think I am okay with that. There just isn't as much time now that the gym is a nearly daily thing.
I did finish We Are Never Meeting In Real Life and Detective Cross (review pending). I am on 16th Seduction by James Patterson and then I plan to start Still Here.
So that's me for the week. What's up with you?


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Welcome to our home on the world wide web!
We're grateful that the virtual world exists so that we can tell you about our mountain farm where we raise Angus beef. We are a small farm in a big agriculture world.
Healing Farm is located in Highland County, Virginia. As the name suggests, we live at a high altitude–perfect for growing nutritious grass. Highland County is the source of two of the East Coast's great rivers–the Potomac and James. Our water is pure and gushes from mountain springs. Land in Highland County is perfect for raising livestock.
On our farm, we serve the land and the wild things that live here–plants and animals.We practice rotational grazing to preserve our pastures. We do everything we can to protect and nurture the cattle that provide us with our income.


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Apartment · New Build
New spacious luxury apartments with sea views on the first line of the Punta Prima beach!
La Recoleta is a luxury gated complex only 150 meters from the sandy beach of Punta Prima. Here you will have extensive green areas, swimming pools and tropical gardens. The complex offers spacious 3-bedroom apartments with spectacular views of the Mediterranean sea. This unique apartments offers big terraces with sea views, green areas and swimming pool. The complex have underground parking and storage room. Installed air-conditioning system and all points of service within walking distance: shopping centers, restaurants, leisure centers and between 2-5 km we have several golf courses, sports facilities, colleges and hospitals.
We are pleased to introduce this wonderful area in Mil Palmeras with wonderful ground floor bungalows. Playa Elisa Costa is only a stone's throw away from the Mediterranean Sea in wonderful Mil Palmeras and offers everything you could wish for for the perfect holiday home or permanent residence. The area is expanding with nice surroundings of parks, the sandy beach only 500 meters away and grocery stores and...