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BOTANICAL PRODUCTS DEVELOPMENT: SBIR AND STTR Release Date: June 22, 2000 RFA: AT-00-003 National Center for Complementary and Alternative Medicine http://nccam.nih.gov/ National Institute of Diabetes and Digestive and Kidney Diseases http://www.niddk.nih.gov/ Letter of Intent Receipt Date: September 7, 2000 Application Receipt Date: November 14, 2000 PURPOSE The purpose of this Request for Applications (RFA) is to support projects that could lead to development of appropriate standardized products and provision of a reliable constant supply of these products as reference reagents for clinical research, including human trials, as well as basic research. The NCCAM has identified at least four herbs (feverfew, valerian root, echinacea, and milk thistle) that warrant further testing in Phase II and/or Phase III trials. Before supporting such trials, several issues regarding the choice of the clinical trial material require special attention, for example: (1) use of different parts of the plants (e.g., roots, aerial parts, whole plant); (2) use of different cultivars and species; (3) optimal growing and harvest conditions; (4) whether to use whole extract or a specific fraction; (5) the method of extraction (e.g., alcoholic, tea, pressed juice); (6) chemical standardization of the product; (7) presentation of the medication (e.g., extract, tablet, capsule); and (8) the dose and length of administration. The goal of each project would be to develop a well-defined product the next step for which would be scaled up to satisfy research needs. This RFA provides a flexible system within the Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs to accommodate the extensive needs and complex development process. It invites grant applications for SBIR and STTR projects with award duration and amounts greater than those routinely allowed under the SBIR/STTR program. This RFA provides a flexible system within the SBIR/STTR program to cover the extensive needs and complex development processes needed to identify/characterize and develop a botanical product. This RFA must be read in conjunction with the Omnibus Solicitation of the National Institutes of Health, Centers for Disease Control and Prevention, and Food and Drug Administration for Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Grant Applications (PHS 2000-2) (https://grants.nih.gov/grants/funding/sbirsttr1/index.htm). The NIH has announced that applicants may request a larger budget and period of support if necessary for completion of the project (See NIH Guide for Grants and Contracts, January 12, 2000) at: https://grants.nih.gov/grants/guide/notice-files/NOT-OD-00-012.html All of the instructions within the Omnibus SBIR/STTR Solicitation apply with the following exceptions: o Special receipt dates o Initial review convened by the NCCAM Division of Extramural Research, Training and Review o Modification of review criteria and/or application instructions o Increased award amount and duration o Additional award consideration o Opportunity for 1 year of Phase I support and 3 years of Phase II support HEALTHY PEOPLE 2010 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2010," a PHS-led national activity for setting priority areas. AHealthy People 2010" does not specify a complementary and alternative medicine (CAM) objective, although this RFA, Botanical Products Development: SBIR/STTR, may be applied to several different priority areas with "Healthy People 2010". Potential applicants may obtain a copy of "Healthy People 2010" at http://health.gov/healthypeople/ ELIGIBILITY Eligibility requirements for SBIR and STTR are described in the NIH Omnibus Solicitation for SBIR/STTR grant applications (https://grants.nih.gov/grants/funding/sbir.htm). Any small business, independently owned and operated by United States citizens or permanent resident aliens may apply. It must be organized for-profit, cannot be dominant in its field of expertise, and must have its principal place of business in the United States. Including any affiliates, the company can be the employer of no more than 500 people. Eligibility is determined at the time of award of Phase I and Phase II The NCCAM will pursue SBIR/STTR funding mechanisms for the four projects described by this RFA. A small business may apply for development of all four botanical products or only one. For each botanical product, the small business must submit a separate application. Only one award will be made for each botanical product project; however, a small business may be awarded projects for more than one botanical product. Note: Applicants may submit investigator-initiated applications for development of botanical products in addition to the four mentioned in the RFA; however, only those applications for feverfew, valerian root, echinacea, and silymarin will be considered responsive to the RFA. Investigator- initiated SBIR/STTR applications will be subject to the standard receipt, review, and award processes described in the Omnibus Solicitation. They will compete for available funds with all other favorably recommended SBIR/STTR applications. MECHANISM OF SUPPORT B PHASE 1/PHASE 2 FAST TRACK This RFA is a one-time solicitation and will use the National Institutes of Health (NIH) Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Phase I/Phase II Fast Track (R44/R42) award mechanism. Responsibility for the planning, direction, and execution of the proposed project will be solely that of the applicant. Applications for Phase I/Phase II Fast Track grants should be prepared following the directions for Fast Track applications as described in the Omnibus Solicitation, which is available electronically at: https://grants.nih.gov/grants/funding/sbir.htm A limited number of paper copies of the Omnibus Solicitation are available from PHS SBIR/STTR Solicitation Office 13687 Baltimore Avenue Laurel, MD 20707-5096 Telephone: 301-206-9385 FAX: 301-206-9722 E mail: firstname.lastname@example.com PROJECT PERIOD AND AMOUNT OF AWARD SBIR Phase I awards normally may not exceed $100,000 total costs (direct costs, indirect costs and negotiated fixed fee) for a period normally not to exceed 6 months and SBIR Phase II awards normally may not exceed $750,000 total costs for a period normally not to exceed two years. STTR Phase I awards normally may not exceed $100,000 total costs for a period of 1 year and STTR Phase II awards normally may not exceed $500,000 total costs for a period normally not to exceed two years. Because the length of time and cost of research involving development and evaluation of botanical products often exceeds that routinely awarded for SBIR/STTR grants, modifications of award durations and amounts will be allowed. The NCCAM will entertain well-justified Phase I/Phase II Fast Track applications for an SBIR/STTR award with Phase I projects up to one year and Phase II projects up to three years and a budget not to exceed a total cost of $500,000 [direct costs, indirect costs, and negotiated fixed fee] per year. PERFORMANCE OF WORK In addition, because these projects may involve multiple disciplines (e.g., horticulture, taxonomy, botany, pharmacognosy, chemistry) and several project sites (e.g., agricultural fields, laboratories), the NCCAM will entertain very well-justified Phase I/Phase II Fast Track applications for an SBIR award with greater than 33% contractual costs in Phase I and greater than 50% in Phase II when those costs are necessary to support development and evaluation of herbal products. Normally the total amount of all consultant costs and contractual costs may not exceed 33% or 50% of the total costs requested for Phase I and Phase II SBIR applications, respectively. Even larger budgets than indicated in PROJECT PERIOD AND AMOUNT OF AWARD could be considered if required to develop a Drug Master File and if appropriately justified in the application. FUNDS AVAILABLE It is expected that four awards (one each for feverfew, valerian root, echinacea, and silymarin) will be made in FY01. The number of awards will be dependent upon receipt of a sufficient number and diversity of applications with high scientific merit. Total costs (direct costs, indirect costs, and negotiated fixed fee) for all four awards in the first year will be up to $2,000,000. Total costs for all four awards over all years will be up to $6,000,000. Awards will be made for either SBIR or STTR grants from funds set aside for these programs. RESEARCH OBJECTIVES Background Definitive randomized, controlled, double-blinded trials investigating the efficacy of feverfew, valerian root, echinacea, and milk thistle for any medical condition have not been reported in the literature. Of the randomized controlled trials that have been done, it is difficult to adequately quantify the clinical effects of the herbs because study designs, outcome methodologies, subject characteristics, dosage, and phytochemical content of the various preparations differ. Given this background, it would be premature for the NCCAM to support large-scale Phase III trials or possibly even Phase II trials with these non-standardized botanical products. Feverfew as Treatment for Migraine Several small, short-term, double-blind, placebo-controlled, randomized clinical trials suggested feverfew (Tanacetum parthenium) to be effective in reducing the frequency of migraine attacks (Johnson 1985; Murphy 1988), the accompanying nausea and vomiting (Johnson 1985; Murphy 1988; Palevitch 1997), and pain intensity (Palevitch 1997). De Weerdt (1996), however, showed no differences in frequency of headache attacks. Each study used different formulations of feverfew, including capsules of freeze-dried, powdered leaves (harvested at one time only), capsules of air-dried powdered leaves (harvested throughout the year), and capsules containing an ethanol extract standardized using parthenolide. The mechanism of action of feverfew in migraine is not known. The plant is rich in sesquiterpene lactones, the principal one being parthenolide. A definitive chemical link between the etiology of migraine and parthenolide or any other of the feverfew constituents has still not been established. The lack of effectiveness of de Weerdt's study, for example, could be due to the absence of essential therapeutic components of the granulated feverfew leaves which were either not sufficiently extracted or perhaps degraded during the preparation. More research is needed, both on a larger scale and with various feverfew extracts, including parthenolide-rich and parthenolide-free preparations. First, a comprehensive profiling of feverfew leaf secondary compounds, examining both the whole leaf and extracts of a broad range of feverfew components, is warranted. Valerian Root for Insomnia There seems to be considerable evidence for the sleep-inducing effects of valerian (Lindahl 1989; Schmitz 1998; Klasser 1984; Gerhard 1996; Balderer 1985; Schultz 1994; Leathwood 1982), and it would appear to be a relatively safe substitute for drugs, such as benzodiazepines, to aid onset of sleep (Houghton 1999; Wagner 1998; Barrett 1999). In addition to valerian alone, other studies with preparations consisting of mixtures of valerian and hops have also shown significant improvement in sleep quality. Because of study limitations, however, it is difficult to adequately quantify the sleep- promoting effects of valerian. Nevertheless, valerian's sedative effect is relatively well established through animal experimentation (Barrett 1999), and the adverse effects profile appears favorable. Valerian is the common name given to a crude drug consisting of the underground organs of species of Valeriana. In Europe the drug is derived from Valeriana officinalis L., but other species are used as crude drugs in other parts of the world (Houghton 1999). Valerian's mechanism of action has not been fully elucidated (Klepser 1999). Valerian is a classical example of an herbal where the overall effect may be due to several types of constituents and modes of activity. The activity of any particular valerian preparation could be due to both the profile of the types and amounts of the constituents present. This underlines the importance of standardizing the preparation both qualitatively and quantitatively, not only in terms of one constituent (Houghton 1999). Since the chemical basis of the observed activities is still not fully known, more work needs to be carried out before a satisfactory standard can be formulated that relates to activity. Echinacea for Prevention/Treatment of Upper Respiratory Infections Few rigorous clinical trials have been performed to demonstrate the efficacy of echinacea as an immune stimulator, although this is a reason for its common use in the United States. A recent systematic review (Melchart 1994) identified 26 controlled trials testing 34 treatments. After consideration of the methodological quality of the trials, the authors were only able to identify one trial (Braunig 1992) that demonstrated clear efficacy and nine trials that demonstrated "indications of efficacy." In a followup article, Melchart (1995) identified 16 randomized trials claiming positive results of treatment (e.g., Dorn 1989, Reitz 1990, Zimmer 1985) and prevention (e.g., Schmidt 1990) of upper respiratory infections. Three of these trials used monopreparations (a species of echinacea alone) and several trials tested preparations that contained plant extracts, homeopathic dilutions, or echinacea as part of a herbal mixture. The authors concluded that while echinacea may be an efficacious immunomodulator, the evidence is still insufficient for clear therapeutic recommendations as to which preparation to use and which dose to employ. There are nine different echinacea plants, but only three are used for medicinal purposes: E. purpurea, E. pallidea, and E. angustifolia These three echinacea plants have been chemically characterized and found to contain the following compounds in varying quantities: polysaccharide, flavonoids, caffeic acid derivatives, essential oils, polyacetylenes, alkylamides, and miscellaneous chemicals (Bauer Wagner 1990). Extracts from the three echinacea species can not be clearly distinguished from each other in terms of their apparent beneficial activity (Dorn 1989). Without knowing a preparation's chemical composition, extrapolation of the results obtained with that preparation compared to others is impossible (Melchart 1995). Multiple chemicals apparently contribute to echinacea's mechanisms of action. To date, there is no universally agreed-on standardization procedure to ensure comparability among products. Given the unequal distribution of active constituents in the flowers, leaves, and roots of the three species, and variation by season, soil type, and climate, it is difficult to determine exactly what kind of standardization would be optimal (Reichling 1998). Also, the dose of echinacea depends on the type of echinacea used, as well as the preparation procedure (Blumenthal 1998). There are different guidelines for extracts, tablets, or capsules. Milk Thistle in the Treatment of Hepatic Diseases Silybum marianum (milk thistle) is currently the most well researched plant in the treatment of liver disease. Silymarin, which is found in the entire plant but is concentrated in the fruit and seeds, is an extract of milk thistle which contains the flavonoids silybinin, silydianan, and silichristin. Silybinin constitutes 60-90% of silymarin and is the component with the greatest degree of biological activity. Milk thistle extracts are usually standardized to contain 70-80% silybinin. Milk thistle is not water soluble and is typically administered as an encapsulated standardized extract. The use of silymarin in chronic liver disease was recently reviewed in the NIDDK/NCCAM symposium, Complementary and Alternative Medicine in Chronic Liver Disease (Seeff 1999 draft). The hepatoprotective properties of silybinin against a variety of hepatotoxins are established by experimental data. The mechanisms that provide silymarin's hepatoprotective effects are many and varied, and include antioxidation, anti-lipid peroxidation, enhanced detoxification, and protection against glutathione depletion. In contrast, the clinical benefits of silymarin therapy are difficult to establish. Conflicting data has emerged from randomized controlled studies in the treatment of chronic liver disease with differing results. No randomized trials have yet been performed in patients with chronic hepatitis C, although small pilot studies have shown a lowering of serum enzymes without accompanying loss of HCV RNA levels. It seems apparent that silymarin has a clearly positive effect on the liver with little to no accompanying side effects, and is therefore deserving of more rigorous clinical trials. The first challenge will be to identify a pure and standardized product and then to consider which form of liver disease is likely to benefit from rigorously developed and conducted treatment trials (NIH Symposium 1999). Significance Standardized formulations of botanical products have not occurred in either the US market or research arena. The development and use of standardized products in research will (1) allow for comparisons across studies using the same products, (2) allow for comparisons between known products, and (3) lead to subsequent, large randomized controlled clinical trials. A reliable and constant source for these products will assure the quality of study outcomes. Objectives The goal of each project is to characterize for each of the four herbs (feverfew, valerian root, echinacea, and milk thistle or silymarin) the standardized product(s) suitable for testing in NIH-sponsored research, including Phase II and Phase III trials. The objectives to achieve this goal are listed below and may be divided between Phases I and II of the SBIR/STTR project as justified by the applicant. Some may be developed as measurable goals for Phase I. After completion of Phase 2, the next step (using other funding sources) would be the production of these products at least in sufficient supply for clinical research. Successful applicants would be expected to participate in an annual meeting in the Washington, DC, metropolitan area with other grantees developing botanical products. It is anticipated that each grant application will include the following: - Review in detail the state of the knowledge on the use of the herb, differentiating between human clinical, animal, and in vitro data, in order to determine the appropriate botanical product(s) to develop and standardize; - Identify accurately the species for the selected herb (botanical description, including comparative descriptions of different species as needed); - Describe the macro- and microscopic physical characteristics; - Provide a standard, high-quality source of the raw material, describing how the plant is grown; where the material is gathered; how and when it is collected, dried and stored to maintain optimal constituent profile; and adulterations and contaminations (presence of insecticide, herbicide, and toxic contaminants); - Develop and document substantiated, qualitative and quantitative analytic methods for the analysis of crude materials; - Identify the constituent (chemical) profile [the HPLC or other profile need not be based on the purported active ingredients, but could serve as a marker or fingerprint (DNA or other) for active constituents]; markers may be defined as those constituents known to be present in the plant that are not necessarily the active constituent; - For each standardized botanical product, identify and describe the species and plant parts from which it is derived, how it is derived (or extracted), the form in which it is provided; - Assess bioavailability, pharmacology, and pharmacokinetics of selected constituents of the profile; - Conduct stability testing of the standardized formulation; - If more than one product for the same herb is developed, compare bioavailability among the different products; - Establish protocols for the production, under Good Manufacturing Practices (GMP), of standardized dosage forms; - Develop the capability to provide the standardized botanical product to NIH- sponsored pre-clinical and clinical trials; - Develop and maintain a Drug Master File at the Food and Drug Administration that will be freely available for cross-reference by researchers participating in clinical trails of the herb. NOTE: It is not the intent of this RFA for the applicant to isolate single active ingredients for drug development. Isolation of single active ingredients is appropriate for identification and standardization of optimal whole products. INCLUSION OF WOMEN AND MINORITIES IN RESEARCH INVOLVING HUMAN SUBJECTS It is the policy of the NIH that women and members of minority groups and their subpopulations must be included in all NIH supported biomedical and behavioral research projects involving human subjects, unless a clear and compelling rationale and justification are provided that inclusion is inappropriate with respect to the health of the subjects or the purpose of the research. This policy results from the NIH Revitalization Act of 1993 (Section 492B of Public Law 103-43). All investigators proposing research involving human subjects should read the "NIH Guidelines for Inclusion of Women and Minorities as Subjects in Clinical Research," which was published in the Federal Register of March 28, 1994 (FR 59 14508-14513) and in the NIH Guide for Grants and Contracts, Vol. 23, No. 11, March 18, 1994, and is available on the web at: https://grants.nih.gov/grants/guide/notice-files/not94-100.html INCLUSION OF CHILDREN AS PARTICIPANTS IN RESEARCH INVOLVING HUMAN SUBJECTS It is the policy of NIH that children (i.e., individuals under the age of 21) must be included in all human subjects research, conducted or supported by the NIH, unless there are scientific and ethical reasons not to include them. This policy applies to all initial (Type 1) applications submitted for receipt dates after October 1, 1998. All investigators proposing research involving human subjects should read the "NIH Policy and Guidelines" on the Inclusion of Children as Participants in Research Involving Human Subjects that was published in the NIH Guide for Grants and Contracts, March 6, 1998, and is available at the following URL address: https://grants.nih.gov/grants/guide/notice-files/not98-024.html Investigators also may obtain copies of these policies from the program staff listed under INQUIRIES. Program staff may also provide additional relevant information concerning the policy. URLS IN NIH GRANT APPLICATIONS OR APPENDICES All applications and proposals for NIH funding must be self-contained within specified page limitations. Unless otherwise specified in an NIH solicitation, internet addresses (URLs) should not be used to provide information necessary to the review because reviewers are under no obligation to view the Internet sites. Reviewers are cautioned that their anonymity may be compromised when they directly access an Internet site. LETTER OF INTENT Prospective applicants are asked to submit, by the receipt date listed at the beginning of this RFA, a letter of intent that includes a descriptive title of the proposed research, the name, address, and telephone number of the Principal Investigator, the identities of other key personnel and participating institutions, and the number and title of the RFA in response to which the application may be submitted. Although a letter of intent is not required, is not binding, and does not enter into the review of a subsequent application, the information that it contains allows NCCAM staff to estimate the potential review workload and plan the review. The letter of intent is to be sent (fax, e:mail, or post) to Marguerite Evans, NCCAM, at the address listed under INQUIRIES. APPLICANT INFORMATION It is expected that applicants will have questions concerning the RFA. In order to clarify the issues and improve the quality of applications submitted in response to this RFA, a Question/Answer web site will be constructed and may be accessed through the NCCAM website: http://nccam.nih.gov/ APPLICATION PROCEDURES This RFA must be read in conjunction with the most current Omnibus Solicitation of the Public Health Service for Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Grant Applications (https://grants.nih.gov/grants/funding/sbir.htm). An example of a sample SBIR Phase I application can be found on the internet at: http://www.nhlbi.nih.gov/funding/sbir/modelsbi.htm. All of the instructions within the Omnibus Solicitation apply except as noted otherwise in this RFA. Applications in response to this RFA are to be prepared as described in the Omnibus Solicitation for the SBIR/STTR Programs, which are available electronically at (https://grants.nih.gov/grants/funding/sbir.htm). Phase I/Phase II Fast Track applications must be prepared according to the Fast Track instructions in the Solicitation https://grants.nih.gov/grants/funding/sbirsttr1/6method.htm#6g. Applications are to be submitted on the applicable grant application forms as follows: PHASE I SBIR GRANT APPLICATION FORM (PHS 6246-1) and REMINDER SHEET https://grants.nih.gov/grants/funding/sbirsttr1/11instructions.htm PHASE II SBIR GRANT APPLICATION FORM (PHS 6246-2) https://grants.nih.gov/grants/funding/sbir2/index.htm OR PHASE I STTR GRANT APPLICATION FORM (PHS 6246-3) and REMINDER SHEET https://grants.nih.gov/grants/funding/sbirsttr1/11instructions.htm PHASE II STTR GRANT APPLICATION FORM (PHS 6246-4) https://grants.nih.gov/grants/funding/sttr2/index.html Phase I application forms are also located in the back pages of the Omnibus Solicitation. Applicants submitting under the SBIR/STTR Fast Track process must prepare and submit both a Phase I and Phase II application together for concurrent initial peer review and evaluation. Fast Track applications must specify clear, measurable goals for Phase I that should be achieved prior to Phase II funding. Failure to provide measurable goals in the Phase I application and/or sufficient detail in the Phase II application may be sufficient reason for the peer review committee to exclude the application from consideration. The Phase II application must be a logical extension of the Phase I research and must include a concise Product Development Plan as described in Section VI, item G of Omnibus Solicitation. Projects may be presented for SBIR/STTR support at all stages of the botanical product development process. Projects will be evaluated on overall innovation and success potential of the research path proposed to botanical product characterization/development. PHASE I: Larger budgets (SBIR and STTR) and longer project period (SBIR) will be considered for Phase I if required for conduct of the research and appropriately justified in the application. Phase I milestones are determined by the applicant but must address some of the objectives outlined in the section RESEARCH OBJECTIVES of this RFA. PHASE II: As with Phase I, requests for larger budgets and longer project periods will be considered. Even larger budgets than indicated in PROJECT PERIOD AND AMOUNT OF AWARD could be considered if required to develop a Drug Master File and is appropriately justified in the application. The second phase of support will be contingent upon the NCCAM programmatic evaluation to ensure that investigators are accomplishing Phase I milestones and time lines presented in the original application. The project=s Phase II objectives should include the objectives outline in the RESEARCH OBJECTIVES section of this RFA that were not addressed in Phase I. In addition, in the Phase II application, applicants should develop a detailed plan for the release of data and the sharing of research materials in order to ensure that data and research materials generated under the SBIR/STTR grant are accessible to the research community for future studies. The adequacy of this plan will be reviewed as one of the criteria for award. Finally, applicants are reminded that the grantee institution is required to disclose each subject invention to the Federal Agency providing research funds within two months after the inventor has disclosed it in writing to grantee institution personnel responsible for the patent matters. NCCAM will monitor the patenting activity associated with these awards to determine to what extent the patenting of program-funded inventions has interfered with the timely dissemination of research data, results and materials. If the approach above is insufficient to ensure the timely sharing of data and materials, the NIH will consider invoking a determination of exceptional circumstances to restrict or eliminate the right of grantee parties to retain title to intellectual property under future grants. Applicants are encouraged to see the Federal Register Notice published on December 23, 1999, entitled, "PRINCIPLES FOR RECIPIENTS OF NIH RESEARCH GRANTS AND CONTRACTS ON OBTAINING AND DISEEMINATING BIOMEDICAL RESEARCH RESOURCES" (64 FR 72090) for an in-depth discussion of NIH principles and guidelines for sharing biomedical research resources. This Notice is also available at an NIH Internet site: http://www.ott.nih.gov/policy/rt_guide_final.html. All of the instructions within the Omnibus Solicitation apply with the following exceptions: - Receipt date; - Increased award amount and duration; - Additional award consideration. Applications will be accepted on or before November 14, 2000. If an application is received after the application receipt date, it will be returned to the applicant without review. The Center for Scientific Review will not accept any application in response to this RFA that is essentially the same as one currently pending review, unless the applicant withdraws the pending application. This does not preclude the submission of substantial revisions of applications already reviewed, but such applications must include an introduction addressing the previous critique. For purposes of identification and processing, the title and number of this RFA must be shown in item 2 on the face page of the SBIR/STTR Phase I applications and in item 1A of the face page of Phase II grant applications (e.g., RFA-00-003, Botanical Products Development: SBIR/STTR). The completed original application and one exact, signed copies must be sent or delivered to: CENTER FOR SCIENTIFIC REVIEW NATIONAL INSTITUTES OF HEALTH 6701 ROCKLEDGE DRIVE ROOM 1040-MSC 7710 BETHESDA, MD 20892-7710 BETHESDA, MD 20817 (for express/courier service) At the time of submission, mail one additional complete copy of the application to the following RFA program administrator: Dr. Richard L. Nahin Director, Division of Research, Training and Review National Center for Complementary and Alternative Medicine 9000 Rockville Pike Building 31, Room 5B58 Bethesda, MD 20892-2182 Telephone: (301) 496-4792 FAX: (301) 402-4741 Email: email@example.com REVIEW CONSIDERATIONS Upon receipt, applications will be reviewed for completeness by the NIH Center for Scientific Review and responsiveness by NCCAM. Incomplete or non- responsive applications will be returned to the applicant without further consideration. Applications will be reviewed for scientific and technical merit by a special emphasis panel convened by the National Center for Complementary and Alternative Medicine, in accordance with the standard NIH peer review procedures. As part of the initial merit review, all applications will receive a written critique and undergo a process in which only those applications deemed to have the highest scientific merit will be discussed and assigned a priority score. Scored applications will receive a secondary review by the NCCAM Advisory Council. REVIEW CRITERIA Review criteria are described in the Omnibus Solicitation. The Phase I application should specify clear, measurable goals (milestones) that should be achieved prior to initiating Phase II. Failure to provide clear, measurable goals may be sufficient reason for the study section to judge the application non-competitive. In addition, the adequacy of a plan for the release of data and the sharing of research materials will be reviewed as one of the criteria for award. AWARD CRITERIA The following will be considered when making funding decisions: quality of the proposed project as determined by peer review, program balance among research areas of the announcement, the availability of funds, and the commercialization status where the small business concern has received more than 15 Phase II awards in the prior five (5) fiscal years, if applicable (see this application requirement under "Prior SBIR Phase II Awards" found in the "Grant Application Preparation Instructions and Requirements" portion of the Omnibus Solicitation). ADVICE ON SUBMITTING APPLICATIONS Potential applicants are strongly encouraged to contact program staff for pre- application guidance and/or for more specific information on the research topics described in this RFA. They are also encouraged to read the advice and information on SBIR/STTR programs located on the Internet at: https://grants.nih.gov/grants/funding/sbirgrantsmanship.pdf INQUIRIES Written and telephone inquiries are encouraged. The opportunity to clarify any issues or questions from potential applicants is welcome. Inquiries regarding programmatic issues may be directed to: Marguerite Evans Division of Extramural Research, Training, and Review National Center for Complementary and Alternative Medicine National Institutes of Health Building 31, Room 5B58 Bethesda, MD 20892 Telephone: (301) 402-5860 FAX: (301) 402-4741 Email: email@example.com Direct inquiries regarding fiscal matters to: Suzanne White* Grants Operations Branch National Heart, Lung, and Blood Institute National Institutes of Health Two Rockledge Center,Room 7150, MSC 7926 6701 Rockledge Drive Bethesda, MD 20892-7926 Telephone: 301-435-0170 FAX: 301-480-3310 Email: email@example.com * The NHLBI is the Grants Management Service Center for the NCCAM. Inquiries regarding review issues should be directed to: Dr. Richard L. Nahin Director, Division of Extramural Research, Training and Review National Center for Complementary and Alternative Medicine 9000 Rockville Pike Building 31, Room 5B58 Bethesda, MD 20892-2182 Telephone: (301) 496-4792 FAX: (301) 402-4741 Email: email@example.com AUTHORITY AND REGULATIONS This program is described in the Catalog of Federal Domestic Assistance No. 93.213. Awards are made under authorization of Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and administered under NIH grants policies and Federal Regulations 42 CFR 52 and 45 CFR Parts 74 and 92. This program is not subject to the intergovernmental review requirements of Executive Order 12372 or Health Systems Agency review. The PHS strongly encourages all grant and contract recipients to provide a smoke-free workplace and promote the non-use of all tobacco products. In addition, Public Law 103-227, the Pro-Children Act of 1994, prohibits smoking in certain facilities (or in some cases, any portion of a facility) in which regular or routine education, library, day care, health care or early childhood development services are provided to children. This is consistent with the PHS mission to protect and advance the physical and mental health of the American people.
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Modern watercolor of multicolored jewels, created by New-York based artist John Torreano (b. 1941) in the late 20th century.
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A vintage French watercolor signed by Guy Legay of a Dewoitine D520 airplane.
A 1940 French watercolor signed by Guy Legay of a Potez 63 airplane fighting Messerschmitt planes.
Two Italian modern watercolors by Giandante X, depicting colorful abstracted forms
A framed watercolor by Alexandro De Canedo entitled "The Neophytes"and painted in 1933. Canedo was born in Mexico City in 1902 to a Spanish father and American mother. At 15 he studied in Paris at the Ecole Nationale Superieure des Beaux Arts under the sculptor Jean Magrou. He held is first exhibition of pencil drawings at the Circolo Artistico in Rome in 1927 and in 1928 moved to the U.S. where his first New York Exhibition of pencil drawings was the inaugural exhibition of the Cheshire Gallery in the Chrysler Building in 1932. He continued exhibiting in and around New York and by 1935 he was showing both watercolors and drawings. He continued producing and exhibiting through the 1940s and relocated to Los Angeles in the 1950s where he was active in the L.A. art scene through the late 60's. He passed away in 1978.
Likely produced, circa 1950s, this expressionist, mixed-media piece by Italian artist Remo Farruggio, is a bold and beautiful depiction of a nude woman in a hat, highlighted by multi-toned flashes of red, green, blue and brown.
Referring to himself as a "abstract phenomenist", the titles of Jenkins' paintings began with the term 'Phenomena', 1960s onward. This particular 'Phenomena' watercolor is highly unique in presence, the applied paint seemingly cropped, forming a neat 'v' shape, which stretches across the paper.
A watercolor painting entitled "Tropical Beauty" by Wladyslaw T. Benda (1873-1948). The piece depicts a young woman and flowers and is set in a wood frame with flower motif carvings.
An Art Deco watercolor painting with mythical themes by Eugene Savage (1883-1978). The study for the ceiling of the Elks Club in Chicago, Illinois. Titled "Muses Bringing Food for the Feast on Mt. Olympus,"and signed in the lower center. Eugene Savage is known for his melding of classical antiquity and modernity. When awarded a fellowship by the American Academy to study in Rome, he dedicated his attention to ancient Greek and Roman Sculpture. His later works reflect this influence whil incorporating modern sensibility. After leaving Rome, Savage was commissioned to pain numerous murals throughout the United States and Europe, including a ceiling triptych in the Elks Club National Memorial in Chicago, for which these were studies. the project was massive and brought together many of the most prominent artists of the time. the composition is subtly surreal, partly as a consideration for viewer position.
This fashion illustration in watercolor and graphite on paper by Sir Cecil Beaton (1904-1980), depicts a costume design for a ballerina dancer of 'The Lady of the Camellias'. Markings include the artist's signature [Beaton] to the lower right corner, [Design for Dancer "La Dame aux Camelias"- New York City Ballet - 1949] to the bottom. Very good condition, any presence of wear consistent with age. Includes original mat; frame new addition.
This watercolor is signed by Joseph Floch (1895-1977) on the lower right.
Our buyer guarantee allows you to shop with confidence at Showplace Antique + Design Center. This pledge to uphold our standard of excellence includes the following guarantees:
We take pride providing reliable service to all of our customers. If you have any questions about this guarantee or any of the services that we provide, please don't hesitate to contact our customer support specialists at firstname.lastname@example.com.

subset: commoncrawl


text:
From a very young age creating art has been important to Mary. She was constantly drawing, painting, and creating things in her youth, and for as long as she can remember her desire has been to be an artist. Mary attended the Crawford College of Art and Design in Cork, Ireland where she graduated with honors in Printmaking.
After meeting her husband and moving to the United States, Mary attended Rhode Island College for a short time to pursue a degree in Art Education, and in the ensuing years was involved in varying degrees with teaching art while busy raising a family.
In 2010, Mary began to study painting with Bruce Becker at The Warehouse Studios in Reading, and ultimately fell in love with oil painting, which quickly became her primary medium. Lately she has begun to explore watercolors, which allows her to express her ideas through a very different creative process.
Mary paints in a very realistic style using a variety of topics. She draws inspiration from the simplicity of everyday life that surrounds us and her desire is to have people see the ordinary in an entirely different light. She is inspired by the early Dutch painters, especially by their use of light and subject matter.
Mary is a member of The Warehouse Studios, Art Plus Galleries, and has exhibited at the Goggle Works, Berks Community, YR Club, Say Cheese, Tri- County Art Show, along with work in private collections. She also teaches middle and high school art at Conestoga Christian School in Morgantown, PA. 1st place in 2015 the Hamburg Area Art Alliance Juried Show.
I would love to hear from you! -Mary Burke


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i am so tirrreeeeddddd
but harry potter, you were so worth it.
proof of our amazing night
(sorry, it's the only group shot.
ps: thanks julie for the photo)
the night consisted of
orange colored hair paint,
spatula & toothpicks for wands,
shallots (for my earrings - i couldn't
find radishes to complete my luna outfit),
a human size marauders map & a fur coat for lucius
to name a few.
i know. we are crazy. but it all ended.
you have to end strong.
and, it was our last night before
carmageddon as well. like i said, end strong.
okay, back to disregard{en}.
just one special piece:
he's going to be great.
hope you have a faaabulous weekend.
disregard{en} will be at melrose
trading post this sunday.
if you are local, take advantage of it.
especially if it helps you avoid
crazy carmageddon.
oh, & if you want some help with
creative solutions to staying
local this weekend in los angeles,
i found this fun & helpful. click here.
happy friday night!!!
see you early next week!


text:
A Master Fund is is a type of collective investment scheme structure whereby investors are able to to invest their money into one or more underlying investments. Generally these types of fund vehicles can be categorized as: feeder funds, fund of funds, or discretionary funds.
Synonyms: Feeder fund, Discretionary fund, Fund of funds
If you have any further questions or would like to add to this fund management term, then please submit your thoughts below.


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Newark-on-Trent is set to be transformed into a land of adventure, heroes and storytelling street entertainment for this year's Newark Book Festival, which will take over the town for the weekend of July 15th-16th.
Back for its third year, the festival's organisers have announced their biggest ever programme of events under this year's theme: Adventures and Heroes! with more than 100 authors, artists, entertainers, wordsmiths and street performers booked for this two-day literary extravaganza.
Venues across the town will be hosting ticketed panel discussions, music, book markets, children's storytelling, family activities and literary talks on everything from crime writing to bear hunts to the BFG and Sherlock Holmes to Steampunk (the full programme can be found at http://www.newarkbookfestival.org.uk/programme).
International best-selling author Matt Haig will be returning to his hometown for a headline talk on his latest novel How to Stop Time, And the jockey Declan Murphy will be discussing his heartbreaking and inspirational true story Centaur in collaboration with writer Ami Rao, who helped him tell his incredible, critically-acclaimed tale of a journey back from a near-fatal racing accident.
Sara Bullimore, artistic director for Newark Book Festival, said: "We're so excited to be building the festival with a new feel, brand and working with more venues to bring a bigger festival to Newark. Our programme is full of fantastic fictional tales and amazing true stories from some of the UK's finest writers; showcasing their talent, stimulating debate and inspiring the next generation of writers.
"We chose this year's theme, Adventures and Heroes, to celebrate Visit England's Year of Literary Heroes, as well as Nottinghamshire's incredible writers. There'll be something for book lovers of all ages, from children's writers and comedy theatre groups to best-selling novelists and the finest local writing talent."
Tickets are on sale now from the Newark Palace Theatre Box Office - call 01636 655755, visit https://www.palacenewarktickets.com/, email email@example.com or buy direct from the venue (Appletongate, Newark, NG24 1JY) between 10am-5pm, seven days a week.
This year's festival venues include Newark Castle, The Market Place, The Town Hall, Newark Library, The National Civil War Museum, Gannets, The Secret Garden Cafe, Millgate Community Centre and River Boat Cruises.
Newark Market Place will be transformed into the Literature Quarter on Saturday, with Sherlock Holmes investigating his toughest case yet in the world's smallest theatre and Doctor Rhyme performing his famous spontaneous poetry salads alongside book stalls, storytellers and chalk artists.
Inside the Town Hall's Council Chambers at 10am, a panel of experts will be discussing some of Nottinghamshire's greatest literary heroes, including Lord Byron, D.H. Lawrence, Helen Cresswell and Alan Sillitoe.
At 11:30am, Crime by the Sea brings the best of the crime-writing festival Hull Noir to Newark, then at 1:45pm Women's Fiction will host writers Cathy Bramley, Eve Makis and Jackie Buxton to discuss their latest novels.
Declan Murphy and Ami Rao will be in The Ballroom at 3:30pm on Saturday, followed by Matt Haig at 6:30pm.
On the Sunday Newark Castle will be hosting The Festival's Famous Adventures, celebrating 75 years' of Enid Blyton's Famous Five as well as face painting, treasure hunts and the inimitable Admirable Admirals.
The National Civil War Museum will feature a series of historical talks on Newark's Air War and the history of the Newark Air Museum, while the nearby Secret Garden Cafe will host A Very Vintage High Tea with The Sunday Times' bestselling author Rowan Coleman discussing her bold novel The Summer of Impossible Things and Rebecca Mascull exploring about her exhilarating new book The Wild Air.
Natasha Pulley, author of The Watchmaker of Filigree Street, will be discussing her latest novel The Bedlam Stacks in The Ballroom at Newark Town Hall at 3pm, while outside in The Market Place the hilarious hi-jinks of The Big Dippers comedy troupe will be on display.
Guests can also show their support for the not-for-profit festival by becoming a Festival Friend for just £15pp (or £25 per couple). Festival Friends will get special ticket offers, invites to an exclusive VIP launch event and free refreshments at all Town Hall events across the weekend.
The full programme can be found at http://www.newarkbookfestival.org.uk/programme. For more details, follow @newarkbookfest on Twitter and Facebook.
Press contact
Author interviews available on request
Rob Tomkinson, Carrington Communications
01507 525284/ 07723602254
Notes to editors
Newark Book Festival is a not for profit literary festival that takes place across the historic market town of Newark. The festival is currently funded by the Arts Council of England, Newark & Sherwood District Council, Newark Town Council and Newark Area for Arts and Leisure Foundation. http://www.newarkbookfestival.org.uk/.
Additional funding comes from local trusts, Waitrose Community Matters, donations and sponsors. Sponsors include: Tallents Solicitors, The Turquoise TeaPot, Duncan & Toplis and Karrot Entertainment. Sponsorship options still available - for more details email email@example.com.
If you are involved in this festival you can update or change details via the organisers page . Authors can list here.
Featured Festivals
Update or list your Literary Festival
Featured Authors
Get your author details listed>>


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Ya'll my search for perfect lighting continues. I've seen a lot of options, at a lot of price points. But, the more I search, the more I come back to this light.
It's dramatic, that's for sure.
Most wouldn't consider hanging a pendant in the middle of a den - a safer option would be a flush mount or semi flush at the most. But not this girl. This girl loves her drama. Have you seen my foyer paper? Plus, there's little risk of bumping into a fixture with the 3' square coffee table below it.
I think it would look stunning in the den. At 24" in circumference, the oversized style will only help to make the room feel more cozy. And against those dark walls? Love.
Of course, it would mean a new mirror over the mantel, but I think I could handle that.
Framed by the built-ins in the living room, the capiz shell pendant would really draw your eye through to the den.
Of course, with heavy afternoon sun streaming through the den windows, maybe there's a reason the previous owner had an overhead fan. Only time will tell on that one, I'm afraid.
Yes, it seems to have everything I am looking for. But, one question remains. Is it timeless? Will I love it in the many years to come?
Tell me your thoughts - persuade me in the comments below.
until next time,


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Refinery29 + Madewell
|Refinery29 Launch @ Madewell woohoo!!!
A Diva State of Mind (L) & The Seventh District (R)
Curious Chase (L) & Day of Major (R)
Because I am Fabulous (L) & Ms Star Styles (R)
TPWP, Spicy Candy DC, & Curious Chase (L) & Vice as If (R)
Heart Print Style (L) & Fab Attendees (R)
Desiree (L) & Two Dilettantes (R)
|Jacket: BCBG / Shorts & Tights: H&M / Clutch & Necklace: Aldo / Shirt: Old / Shoes: Miu Miu
|I seriously couldn't rotate this pic...oh well
I had such a great time last night at the Refinery29 launch. I love going to these events because it gives me the opportunity to catch up with all my blogger boo's in the area lol. I bet some of them are laughing as they read that haha!!! But I really just enjoy being around people who are passionate about fashion, I love that there are so many different bloggers with very different styles, and when we gather at these events we get so inspired by each other. So cheers to Refinery29 and welcome to DC, I hope you're ready for us ;) !!!!


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- Editor Rating
- Rated 5 stars
- Spectacular
- Jason Bond Picks
- Reviewed by:
- Published on:
- Last modified:
- ValueEditor: 96%
- QualityEditor: 100%
*This is the only service that I actively use myself. Former public school teacher Jason Bond is ready to teach you everything you need to know about online stock trading – even if you have no previous experience whatsoever. His platforms offer videos, articles, and an active stock trading chat room. Thousands of satisfied traders have learned the Jason Bond system for Day Trading, Swing Trading, and Long-Term Trading. At just $399 for three months of access, you can gain enough know-how to trade successfully for a lifetime.
Trading stocks is fast-paced and time intensive. Unfortunately, most people just can't afford to devote so much time to all the research and effort successful trading requires. Saving time is where Jason Bond's system can help.
Bond and his team do the research on your behalf. They provide ten simple trades each week as teaching tools. Within three months, the Jason Bond method will teach you the in's and out's day trading, swing trading, long-term trading and more. They even include a "Millionaire Roadmap."
If you're new to online trading, is Jason Bond Picks the right teaching tool for you? Is the site easy to use while also providing powerful features? Are the people behind the scenes knowledgeable and helpful?
I spent some time looking into all the subscription features and resources on Jason Bonds website. My complete review is below:
The home page opens with a pic of Jason Bond himself and a synopsis of his 90-day system. Personally, I always prefer a site where one person is the main face of the site. This usually means customer service will be excellent because the organization is small enough to be reactive to your needs.
Truly support within Jason's service is great, If you have a question just email him and he will personally get back to you.
Services Offered:
Here's a look at the main page for Subscribers:
There are three main areas. On the left side is a list of the major services offered. To the right of that section is the big blue button which takes you to the Day Trading Chat. Below that button is the Daily Watch List with a list of trades to know.
Here's an in-depth look at each feature:
Day and Swing Trading Chat Rooms
This is the most popular feature on the site and where you'll find most subscribers gathered during the trading day. The chat room has a clean, easy-to-read layout and design. See for yourself here:
In the left-hand column, you can see everyone who is in the Chat Room. The names in green are subscribers while those in purple are members of Jason's hand-picked team of experts. You can click on each name to send a private message or even mute the person.
Note that you'll probably never have to mute any fellow subscribers. The chat rooms are carefully monitored for off-topic and inappropriate comments. The focus is entirely on trading. I found the other traders to be friendly, fun and dedicated.
There are consistent "free chat room days" that let you have temporary access to all the information in the room. Upcoming free chat days are sent out to his free email list.
In the middle portion of the bottom is the General Chat and Coffee Lounge. These are two different chat rooms. The General Chat is for discussion related to the current trades. The Coffee Lounge is for more informal discussion about day trading in general.
On the bottom right of the screen is an updated list of all the trades made by the pros during the trading day. You'll see when they short, sell and take other trading actions. You'll need to understand stock symbols to really get much from this section.
Long-Term Trading
This type of trading is for those who don't necessarily want to make money today. Instead, they want their net worth to climb steadily over time. This type of trading is designed for retirement or even early retirement.
The Long-Term Trading plan contains:
- 1 to 2 swing trades each week
- 1 to 3 long-term trades each week
- Email and text alerts whenever Bond buys or sells a stock
- Detailed Watchlist with long-term stocks to keep an eye on
Long-Term trades have another bonus, too. Besides Jason Bond, long-term traders will also receive customized advice from Jeff Bishop. He's the founder and manager of Top Stock Picks. You'll be able to access his real money portfolio, which is built entirely from ETF's.
I liked the Long-Term Trading plan offered here. In my opinion, too many online traders focus too much on the day-to-day action. While this is obviously an important aspect of day trading, most day traders ultimately want to achieve financial success for the rest of their life. This Long-Term plan helps people achieve those financial goals.
Swing Trade Daily Watch List
These are daily notes directly from Jason himself. Each Watch List contains a summary of the day's trading events including stocks to watch, links to relevant information and even Jason's personal thoughts on current market trends. Here's an example of what these Watch Lists look like:
Bond has two types of watch lists, both with a similar format. The one above is an example of the Daily Watch List designed to keep you informed on all the news related to that day's market behavior. The second type of Watch List is mentioned in the earlier Long-Term Trades investigation, and emphasizes stock picks which might not have a lot of excitement today, but look promising for high returns in the future.
Penny Stocks 101
Turning a small investment into a big return is one of the most appealing aspects of online trading. Penny stocks are about as small of a stock as you can find – but with expert trading, you can create a pretty sizable return.
Bond has an extensive series of video tutorials about Penny Stocks. Here's what that section looks like:
As you can see, each video allows comments. This is often a great place to ask any questions you might have about the lesson. Jason Bond will almost always personally reply with helpful tips.
Jason Bond and His Team
When I initially landed on the home page, my first question was probably pretty basic: "Is Jason Bond a real person?" After all, his name seems like it could be completely made-up. It turns out, he's a real person, and his background is rather remarkable.
Jason even does live chats weekly where he answers trading questions and gives advice.
Jason Bond has a detailed video on his site explaining his story. Originally, Bond was a teacher in the New York public school system. While he does say he enjoyed the work, he also admits he was living paycheck to paycheck and struggling financially.
He began online day trading. At first, he wasn't fantastic. But over time he developed a system. In the past four years, he said he made over $400,000. He said this is more than when he earned during ten years of teaching!
He started Jason Bond Picks to teach other new traders about his system. He was able to quit his teaching job and devote 100% of his time to online trading. But although he no longer works in a public school, he certainly never gave up on teaching.
Whether in print or a video, Bond knows how to teach. Online trading can be pretty complicated and fast-paced. Thankfully, Bond's teaching style is anything but. He explains everything you need to know in a clear, direct way. You can see he uses a lot of teaching techniques from his days as a public school instructor.
A Personal Connection
Unlike many online traders, Jason Bond Picks is primarily a one-man show. While he does have a team of pros working with him, Bond has a very hands-on approach. In his introductory video, he prides himself on reading and responding to every email sent to him by subscribers – usually within a day!
This was very refreshing to see. I felt a lot more confident following the trading advice of a real guy who puts his money where his mouth is. I can watch, in real-time, Jason Bond make his trades during each trading day.
Every trading site has testimonials, but I honestly can't remember seeing as many in one place as on Bond's site. In his video, he talks about how he has over one thousand testimonials from satisfied traders who have used and benefited from his system.
I think one reason for this considerable number of testimonials is Bond's honesty. He isn't afraid to acknowledge when he's made a mistake. In fact, I watched one testimony where a subscriber talked about how he learned more from Jason Bond's failures than his successes. When the trading day isn't a stellar one, Bond provides a detailed analysis of what went wrong.
I don't want to give the impression that Bond has a ton of less-than-stellar trading days. More often than not, you'll learn why today's trading went well. But when it doesn't, Bond doesn't shy away from discussing trades which performed poorly.
Bond's track record speaks for itself. This year alone he's already up over $280,000, which is a 280% return on his investment.
Subscription Plans and Prices
Many day trading platforms offer three variations of what is basically the same program with different levels of access. Jason Bond Picks does something a bit different. They have three plans based on various types of services:
The most popular one is their Day and Swing Trading package. This is the most traditional day trading option. Subscribers get ten swing trade buy and sell alerts each week. You can receive these real-time alerts via any combination of chat, text, and email.
This package is designed for those new incredible trading as well as those who are too busy to research the stock market all day long.
The next Subscription package is the Long-Term Trading plan. This is designed for those who don't have the time to trade during the day. The Long Term is a yearly plan.
With the Long-Term Trading program, you'll get up to two swing trades and up to three long trades. You'll also get a list of stocks which Jason has identified as having long-term potential for growth.
Finally, the third Subscription plan is the Millionaire Roadmap. This gives the user access to all of the features on the platform. You'll also get a personalized mentorship program from Jason Bond himself.
Before you purchase a plan, you need to understand the company's refund policy. Namely, no refunds are allowed. The idea is that every bit of trading info you learn has value. Once you sign up for the service, you're committed for at least a month – and canceling two days before the next renewal is entirely your responsibility.
- Jason Bond. With a proven track record and clear, straight-forward teaching style, Bond has a lot of knowledge to offer both novice and veteran traders.
- Diverse investment options. Whether you're looking for fast action every day or a long-term approach to financial security, JBP has a plan suited to your needs.
- Active community. Connect with other traders anytime day and night, not just during the market day.
- The support staff. Don't get me wrong – the support staff is highly knowledgeable, friendly and professional. But when the entire site is based on one guy, I'm primarily interested in hearing what that guy has to say. I admit feeling a little disappointed when interacting with anyone on the site who wasn't Jason Bond except Luke Murray.
Is Jason Bond Picks Worth the Money?
- If you don't think you can afford the service at this time but still are very interested sign up for his free email list. In addition to weekly stock tips, you will receive any deals that Jason releases. Often around the holidays, he will release a promotion that will get you in at a lower price. All prices are grandfathered, so the price you get in at is the price you pay for life.
However, Jason Bond has personally made roughly $100,000 a year using these strategies. You'll be using the same strategies which brought him such amazing success. Personally, I feel this makes the fees seem much more reasonable.
If you're new to online stock trading, your best bet is the three month Day and Swing Trading Plan. This lets you check out the entire site and get a feel for Jason Bond's teaching style. Plus, if you follow his lesson closely, I feel it's pretty likely you'll at least make $400 in three months. This means, at the very least, you're not losing anything.
Jason Bond Picks is a step above other online trading sites simply because Bond himself knows how to teach. After all, if you don't understand the trader's system, then the system's effectiveness is irrelevant. With Bond, you have access to articles and videos created by someone who knows how to communicate complicated info in an easy-to-understand way.
Along with knowing how to teach Jason resets his trading account to 100,000 each year to show that he can start with a small account and grow it.
I recommend this online trading system for anyone interested in learning more about day trading. Even complete beginners will find a comfortable home here.
Have you been in one of Jason Bond's virtual classrooms and learned about his system for yourself?
Check out his other related services.
Rate this service for yourself below or leave a comment.
Jason Bond Picks Review
Jason Bond Picks
Summary: *This is the only service that I actively use myself. Former public school teacher Jason Bond is ready to teach you everything you need to know about online stock trading – even if you have no previous experience whatsoever. His platforms offer videos, articles, and an active stock trading chat room. Thousands of satisfied traders have learned the Jason Bond system for Day Trading, Swing Trading, and Long-Term Trading. At just $399 for three months of access, you can gain enough know-how to trade successfully for a lifetime.


text:
Dr. Cuttriss founded ENDO Diabetes & Wellness in order to provide
a more practical and efficient way to care for and empower children and their
families who are living with chronic pediatric endocrine conditions.
At ENDO Diabetes & Wellness, Founder and Medical Director, Dr. Nicolas Cuttriss, is determined for you to receive the level and quality of care and attention that he would expect for his own children.
Dr. Cuttriss founded ENDO Diabetes & Wellness in order to provide a more practical and efficient way to care for and empower children and their families who are living with chronic pediatric endocrine conditions. By integrating the latest in medical and technology advances with practical lifestyle changes, ENDO Diabetes & Wellness offers a comprehensive management approach to empower children and their families to live happy and healthy lives with chronic pediatric endocrine conditions.
Endo diabetes and wellness:
children, adolescents, and college-age young adults transitioning
to adult management with pediatric endocrine conditions.
in Pediatric Diabetes and Wellness
(obesity prevention and management) with annual comprehensive
management planning for diabetes and obesity patients.
unlimited phone and email access
to your doctor and healthcare team.
TeleHealth opportunities for remote scheduled
appointments with your doctor and healthcare team, a user friendly
patient portal, and easy online scheduling.
diabetes technology and continuous glucose
monitoring (CGM) in our comprehensive diabetes management program
Billing and Insurance Policy:
ENDO Diabetes & Wellness does not currently maintain contracts with insurance providers. Reimbursement of any service provided (including monthly review of Continuous Glucose Monitoring and TeleHealth) is at the discretion of your insurance company under the terms of your agreement.
At the end of each month, ENDO Diabetes & Wellness will send you an invoice that you may submit to your insurance company for reimbursement under the terms of your arrangement with them. All families are responsible for paying ENDO Diabetes & Wellness directly for services. Monthly plans are available for diabetes and wellness patients.


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This hotel is NOT
The Hampton Inn – Suites Phoenix Chandler-Fashion Center will make you feel right at home in the southeast area of the Valley of the Sun in the Price Road Corridor. Surrounded by the beauty of the desert Chandler Arizona is home to offices of several Fortune 500 companies such as Intel Wells Fargo and Avnet. Whether traveling to the area for business or pleasure Hampton Inn – Suites Phoenix Chandler-Fashion Center places you right in the middle of everything you need including some of Arizona*s finest upscale shopping at the Chandler Fashion Center and many world-renowned golf courses. Located just minutes from Phoenix Sky Harbor Airport Historic Downtown Chandler Chandler Air Park Tempe and Arizona State University. Attractions close to Hampton Inn – Suites Phoenix Chandler-Fashion center include * Chandler Fashion Center * Historic Downtown Chandler * Snedigar Sportsplex * Rawhide at Wildhorse Pass * Ashley Manor * Lone Butte – Gila River Casinos * Firebird International Raceway * Bob Bondurant School of High Performance Driving Featuring standard rooms with two queen beds or one king we also offer studio suites our Hampton Inn – Suites Phoenix Chandler-Fashion Center offers guests a great taste of Arizona Hospitality. Conveniently located we are near some of the valley*s largest companies * Intel * Rogers * Avnet * Countrywide/Bank of America * Microchip * Orbital Sciences Corp * Wells Fargo * Verizon * Americredit – many more. Guests of the Hampton Inn – Suites Phoenix Chandler-Fashion Center will enjoy a number of services in order to make your stay in North Phoenix as comfortable and memorable as possible. Choose from our studio suites and standard rooms in which you*ll find * Flat screen television with a large selection of premium cable channels * Two telephones with data ports and voicemail * Complimentary wired and wireless high-speed internet access * Custom-designed alarm clock If you love a hot breakfast in t
If you are the owner of a Pet Sitting or a Dog Walking business in Chandler, Arizona and wish to add your business listing free of charge to this city please submit your info here.


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William Pope.L
William Pope.L is a visual, theatre, performance artist, and educator who makes culture out of contraries. A graduate of the Mason Gross School at Rutgers, he has been working inter-disciplinarily since the 1970s. His 2001 travelling retrospective entitled eRacism, and its companion monograph, The Friendliest Black Artist in America, published by MIT Press, highlight a provocative and exceptionally diverse career. His 2003-2007 mobile performance project, The Black Factory, is, at once, a digital archive, a nomadic caravan, a social service community and was recently installed as an exhibition at Yerba Buena Center for the Arts, San Francisco. Pope.L has exhibited widely, including the Whitney Biennial (2002); the Dakar Biennial (2006); the Frieze Art Fair (2006); and has upcoming solo exhibitions at the Santa Monica Museum of Art and the Art Institute of Chicago (both 2007). He is represented by Kenny Schachter Rove in London, MC Kunst in Los Angeles and The Project in New York City.


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Anthology release
URL Love: From Texting to Twitter, the Hottest Online Love Stories
My short story, THE TWEETEST THING, is available now in HarperCollins's women's fiction e-book anthology. Download it from Amazon and iBooks.
The long story behind my short story...
Back in March 2012, my boss treated me to my very first Duran Duran concert. Amazing live act. So inspired was I that I wrote a short story, The Tweetest Thing, about a woman who tweets and meets her idol.
Months later, I saw DD again in Saratoga, CA. The following morning, Simon Le Bon totally made my millennium when he retweeted my tweet to him the day after. (See evidence in the gallery below. Seriously, I'm not letting anyone forget this highlight of my cyber life. #tragicfan)
A week or so after that, HarperCollins accepted The Tweetest Thing for publication in anthology. That anthology was released within days of DD bassist John Taylor's excellent memoir.


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Due to logistical, environmental or safety reasons, the guidelines given for the road and obstacle courses on event day take precedence over the guidelines given on this page.
Unsportsmanlike Conduct
The Hercules Fitness Challenge will not tolerate unsportsmanlike conduct. Examples may include, but are not limited to; foul language, aggressive behavior toward fellow participants, spectators or Hercules Officials, damage to obstacles and physical property, etc. Participants found in violation of this guideline are subject to immediate disqualification and may be asked to exit the venue.
Obstacle Officials
Each obstacle on the course is monitored by Obstacle Officials. Obstacle Officials direct the flow of traffic and enforce proper execution and completion of the obstacle. If a participant does not wish to attempt the obstacle, the participant must proceed to the Burpee Zone. Participants may attempt the obstacle as many times as they wish. Upon proper execution and completion of the obstacle, participants advance to the next obstacle. If a participant cannot properly execute and complete the obstacle, an Obstacle Official will send the participant to the Burpee Zone.
Burpee Zones and Burpee Officials
Each obstacle on the obstacle course has a Burpee Zone and is monitored by a Burpee Official. Burpee Officials enforce proper execution and completion of burpees. Participant's sent to the Burpee Zone by an Obstacle Official must properly execute and complete the required number of burpees to advance to the next obstacle. If a Burpee Official determines that the participant's burpees are not being executed properly, the Burpee Official may direct the participant to redo improperly performed burpees.
All obstacles are Completion Mode. Completion Mode means the obstacle must be properly executed and completed to advance to the next obstacle. Completed means by any means necessary; help from a friend, teammate or stranger...GET IT DONE! If you can not complete it, an Obstacle Official will direct you to the Burpee Zone.
The Burpee Penalty per category of difficulty. Beginner athletes will be responsible for completing 10 burpees before moving on. Intermediate athletes will be responsible for completing 20 burpees before moving on. Advanced athletes will be responsible for completeing 30 before moving on.


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In a market where buyers are scarce, sellers need to look at all the options to snag a sale. Owner financing is one option available to sellers, but many expats are scared to death of the courts and shy away from carrying a mortgage.
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Dessa Kirk is a Chicago sculptor known for making large-scale lilies and depictions of women from Greek mythology. Her installations include "Daphne Garden" as part of Chicago's Art in the Garden series.
One of the themes in her work is finding the hidden beauty in ugliness, and she often makes her pieces from scraps of discarded Cadillac cars. Her sculptures are huge and rugged looking, ranging from raw to elegant.


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[Cosplay] I Love People!! -Durarara!! Part 1-
I am becoming nervous because I have had too many glad things since this year started. What is waiting for me next? Well, after I had a photoshooting of Durarara!! cosplay I was so disappointed to see the photos we took, because almost all of them were not good at all. Because of my camera? Yes. But the crucial reason is, I guess, the time when the photoshooting took place. I mean if you have watched Durarara!!, you would know from what time Shizuo and Izaya start to move, wouldn't you? The lead school students are in active during daytime, but as for the two guys, those scenes in which they show are mostly at night. So that is why the photos look boring. Then what shall I do? Try again at night? That's it, but it is not that simple because it is really difficult to take a photo at night. I needed a much better camera or someone who can handle something like this. One person came to my mind right away, yes, he is the photographer who helped me with my cosplays at the hotel. When he showed me his photos inside his camera, I saw some night shots and they looked awesome. I screwed up my courage and asked him to help me, and he said yes. Oh my god, lucky me! I immediately told my uke-partnerKeith who cosplayed Izaya about this…and this is how we had a photoshooting.
Around 18:00 or so, we three met up at Ikebukuro Station, and started a photoshooting. Because we started from that hour, there was almost no people who could recognise our cosplays as I guessed. And there were a few things I really wanted to do; a fighting scene and chasing scene. And some spots I really took; Tokyu Hands and Sunshine Cinema. We did it all! I was so pleased, and there was nothing else to wish for. Thank you very much, Izaya and the photographer! I will never forget this. Oh I shall explain one term, リベンジ[revenge] to mean to re-do the same cosplay to do better than before. My リベンジ went so well!!
人 ラ ブ!!
Here ends part 1 because there are too many photos to upload here. In part 2, you will see fighting scenes or that kind of thing. Please stay tuned! I will be back.
13 Comments
[Cosplay] I Love folks!! -Durarara!! Part 1- « Japanese words of … | Hotel Confirm said,
[…] bangin Share and Enjoy: These icons link to social bookmarking sites where readers can share and […]
fantasy2311 said,
omg…. i luv the photo with the phone. a pity its not really being stomped on (lolz). the night background really does accentuate hair and sunglasses and izaya's fur on his coat. the whole shady feeling is good as well. the 2 BL-ish photos r my favs as well as the ones on the bridge.
Marie said,
Kyah~ (//▽//)
You guys look amazing (☆o☆)
I think it's the background that's synchronizing flawlessly with the anime!
Great job ^^b
Inktrap said,
Gorgeous photos, I love the ones in front of the vending machines. The light wraps all around you, it looks so cool! Because of the products behind, the photos end up being colorful despite the dark atmosphere, the same as with the lights of the city. So pretty…! The poses are amazing. My favorite is this one where you have your foot on the wall, it's so full of attitude!
仲魔 said,
Such good lighting! It reminds me of a suspense movie. Between the pictures with a shadowed face, and the other pictures that show your faces clearly, each has a good atmosphere. I'm really glad for you that you met that photographer 🙂
Goods: ^%$#@! WAKE UP (Durarara!! Izaya + Shizuo Voice Clock) « Ponytale in LalaParadise said,
[…] Awesome cosplay by bangin-san here Part I and Part II ^^ Tags: DRRR!!, Durarara!!, fan service, Heiwajima Shizuo, Kamiya Hiroshi, Ono […]


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matilda has an announcement…..
congratulations amanda! be looking for an email from us in your inbox in just a bit.
a BIG thanks to everyone that participated in the gift-away & all the kind feedback!
as a side note:{our spring accessory shopping page will be open on monday}
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
now for a tutorial.
2 to 3 yards of gingham fabric . coordinating thread . fabric scissors . shows on your DVR {optional} . iron + ironing board . sewing machine . pin or fabric marker
{30 minutes prepping, 10 minutes sewing, 1-2 hours fringing}
NO. 1, decide on the size you would like your scarf.
our's is pretty long: 17 x 87″
if you have a favorite scarf in your closet, grab it to use as a guide for cutting.
NO. 2, decide how long you would like your fringe and mark with a pin or fabric marker.
NO. 3, fire up the DVR and….
let the fringing begin! pull each thread out away from the fabric {if pulled through the fringe, it's easy to get stuck & break}.
NO. 4, fold a small hem along the long side {non-fringed} of the fabric….
iron it down so it stays put.
NO 5, fold over a second time {to hide the unfinished edge} and iron.
NO 6, check your sewing machine settings.
i have mine set to a straight stitch, top thread tension 4, needle position 5 {so it sews closer to the inside fold… if your machine is set to a zig zag, this setting will determine the width of the stitch}, & stitch length 2.
NO 7, now sew along the fold that you so diligently ironed. i used the 1/8″ seem mark as my guide…. depending on the width of your fold, you may want a wider seem.
NO 8, when you get to the end of your fabric, remember to back-stitch.
NO 9, repeat NO 7 & 8 along the other side of the scarf.
NO 10, enjoy your creation & don't worry about any flaws you see… you are the only person that will notice them.
this may or may not be encouraging, but i've owned several sewing machines since i was a little girl {how much time i've spent using them is a different story} but i still find myself saying "shoot!" or {my 4 year old's fave}, "poop!" throughout different projects. {note the troubled bobbin above. bobbins in general stress me out}….. sometimes the problem is the machine, other times it's the operator. either way, it's usually a 30 second or so fix and it does get easier!
especially if you take the time to read the sewing machine manual. i've only sort of done this, so while looking for some info about my machine over the weekend i also discovered that it is outfitted with an automatic needle threader…. incredible!
let us know if you have any questions, ideas for new toots or a fun sewing story.
also, if you make a scarf we would love to see it! you are always welcome to post pictures on our facebook page!
xo . rae


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FOUND IN TITLES: number of results: 1
Home mechanical ventilation in a patient with Duchenne muscular dystrophy
Duchenne muscular dystrophy (DMD) is a hereditary progressive neuromuscular disorder that is inherited in X-linked recessive pattern. Mutation of dystrophin gene results into a loss of integrity and function of muscular fibres and their replacement by adipose and connective tissue. Muscle degeneration leads to motoric impairment and loss of walk around 12th year of age. Myocardium is also frequently affected. Respiratory muscles impairment and other complications lead to respiratory failure. If left untreated, death occurs around 20th year of life, usually due to cardiac or respiratory causes. Respiratory insufficiency development is treated by mechanical ventilation support.
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CLOSED SESSION at 6:30 p.m. – The Board convened in Closed Session pursuant to California Government Code § 54957(b):
PUBLIC EMPLOYEE PERFORMANCE EVALUATION Title: Executive Director
Upon the Board's return from Closed Session, Chair Stephens announced that the Board took no action.
PUBLIC EMPLOYEE PERFORMANCE EVALUATION Title: Executive Director
Upon the Board's return from Closed Session, Chair Stephens announced that the Board took no action.
1. Roll call – Chair Stephens called the Regular Meeting to order at 7:27 p.m. (The start time was delayed due to the earlier Closed Session taking longer than expected.)
Commissioners present: Blake, Dodsworth, Harr (left 9:52), Shelton, Townley, Tregub, Webster, StephensCommissioners absent: DrakeStaff present: Brown, Kelekian, Law (in audience), Mueller
Commissioners present: Blake, Dodsworth, Harr (left 9:52), Shelton, Townley, Tregub, Webster, StephensCommissioners absent: DrakeStaff present: Brown, Kelekian, Law (in audience), Mueller
2. Approval of Agenda M/S/C (Tregub/Webster) APPROVE AGENDA. Voice vote. Carried: 8-0-0-1. ABSENT: Drake.
Prior to the approval of the agenda, Commissioner Tregub gave an eloquent and heartfelt farewell address in which he conveyed his pride in the Board's many accomplishments and the projects he has been a part of during his tenure, including: two internship programs which provide valuable public policy experience and college credits to university students; the congressionally-recognized Foreclosure Prevention and Resources Workshop that connected HUD-certified housing counselors, attorneys, banks, Rent Board housing counselors with homeowners, landlords and tenants affected by the foreclosure crisis; the crafting of a revised Relocation Ordinance that now provides stronger protections for tenants and greater outreach to property owners; the successful collaborative effort to advocate for the maximum feasible Affordable Housing Mitigation Fee at the local level; strengthening of property owner compliance with Phase I of the Soft Story Ordinance; vast improvements in data collection and tracking via the ongoing upgrade of the Rent Board's Rent Tracking System database; vital outreach and financial assistance to victims of the devastating Haste Street fire via a Rent Board grant program; and revisions to the Demolition Ordinance. Commissioner Tregub expressed his appreciation for his fellow Commissioners, and congratulated the newly-elected Commissioners, Alejandro Soto-Vigil and Judy Hunt. He also thanked the "awesome" staff of the Rent Stabilization Program and its Executive Director, Jay Kelekian.
3. Public Forum There were four speakers: David Blake, as a member of the public, congratulated Commissioner Tregub on his four years of dedicated service to the people of Berkeley; he also stated his concern regarding the questionable financial practices of the Tenants United for Fairness (TUFF) Slate; Chris Smith, a lifetime Berkeley resident, spoke about an inspection and eviction at 1828 San Pablo Avenue and his frustration with what has transpired; Juan Maravilla spoke on behalf of Chris Smith and asked that the Board assist him with his situation; and Jamie (no last name provided) echoed Chris Smith's statements and her concern about the behavior of the property owner of 1828 San Pablo and how the eviction was handled.
4. Approval of prior meeting minutes:
a. October 15, 2012 Regular Meeting minutes – M/S/C (Townley/Blake) HOLD OVER TO NEXT MEETING. Voice vote. Carried: 8-0-0-1. ABSENT: Drake.
b. November 10, 2012 Special Meeting minutes M/S/C (Harr/Townley) APPROVED WITH ONE CHANGE: ADD A STATEMENT REGARDING THE ACTION TAKEN BY THE BOARD DURING CLOSED SESSION. Voice vote. Carried: 8-0-0-1. ABSENT: Drake.
5. Special presentation by Christine Minnehan, Rent Board Legislative Advocate and Michael Moynagh. Christine Minnehan and her associate, Mike Moynagh, gave an overview of current and pending housing legislation and took questions from the Board.
6. Action Items a. From Board Members, Executive Director and Committees
(1) Recommendation to adopt a resolution authorizing the Executive Director to amend the contract with Software A.G. in an additional amount not to exceed $50,400, to replace and enhance the remaining portion of the Rent Tracking System (RTS) database and establish a Web-based interface to allow customers the ability to pay registration fees online (Executive Director) M/S/C (Blake/Tregub) ADOPT RESOLUTION AS WRITTEN. Voice vote. Carried: 8-0-0-1. ABSENT: Drake.
(2) Discussion and possible action regarding Proposed Berkeley Municipal Code Chapter 13.79 – Automatically Renewing Leases (Executive Director) M/S/C (Harr/Townley) Direct staff to send a letter indicating the Board's support of this proposed ordinance and discuss ways to conduct outreach to tenants who are not covered by its provisions. Carried: 8-0-0-1. ABSENT: Drake.
(3) Proposal to approve staff recommendation on the following requests for waiver of late registration penalties (Executive Director)
Discretionary Waivers
Discretionary Waivers
Waiver No. Property Address4222 2711 Forest Avenue
M/S/C (Townley/Tregub) Approve the staff recommendation for Waiver No. 4222. Voice vote. Carried: 8-0-0-1. ABSENT: Drake.
7. Information and Announcements a. Reports from Board Members/Staff (1) Update on the implementation of Regulation 1282 (Executive Director)
(2) Market Medians report for the 2nd Quarter of 2012 (Executive Director)
(3) 2nd Quarter 2012 report on U.S. Housing Market Conditions from the U.S. Department of Housing and Urban Development (HUD), and six recent news articles related to landlord-tenant issues (Executive Director)
(4) November 13, 2012 e-mail from Ralph McFerren expressing concern about the lack of affordable housing in Berkeley (Executive Director)
(5) November 8, 2012 letter to the Berkeley Housing Authority Board from Tia M. Ingram, Executive Director of the Berkeley Housing Authority, regarding the Section 8 Project-Based Voucher Program (Executive Director)
(6) October 9, 2012 letter from U.C. Berkeley Associate Vice Chancellor LeNorman J. Strong in response to the Executive Director's September 6, 2012 communication regarding construction of additional student housing (Executive Director)
(7) October 18, 2012 San Francisco Examiner article by Joshua Sabatini titled, "Legislation would require disclosure of bed-bug infestations" (Commissioner Harr)
(8) Update on Waiver No. 4147 (1522 Woolsey Avenue) (Executive Director)
b. Updates and Announcements regarding Committee/Board Meetings
(1) Budget and Personnel – Committee Chair Tregub said that all the Committee's recent work has already come before the full Board.
(2) Outreach – Committee Chair Webster updated the Board on the Committee's recent work.
a. October 19th agenda
b. November 16th agenda
(3) IRA/AGA and Habitability – Committee Chair Stephens updated the Board on the Committee's recent work.
a. November 19th agenda
(4) Eviction/Section 8/Foreclosure – Committee Chair Harr said the Committee is looking forward to the Eviction Defense Center's presentation at their next meeting on December 12th.
a. November 14th agenda
(5) Safe & Sustainable Housing – Committee Chair Townley said the Committee has not met recently.
(6) Waivers Committee – Committee Chair Dodsworth pointed out the revised Guide to Fees and Penalties was passed out to the Board this evening (off-agenda).
(7) Ad Hoc Committee on Smoke-Free Housing – Committee Chair Blake gave the Board an update on the Committee's work and the latest movement on the draft Smoke-Free Housing Ordinance.
a. November 16th agenda
(8) 4 x 4 City Council/RSB Housing Committee
(9) Future Special Meetings
c. Discussion of items for possible placement on future agenda:
1. Discussion of anonymity of callers when contacting the Rent Board staff for counseling or information
2. Discussion of emergency supply cache program
8. Continuation of CLOSED SESSION – The Board will reconvene in Closed Session to discuss the following:
Pursuant to California Government Code § 54957(b):PUBLIC EMPLOYEE PERFORMANCE EVALUATION Title: Executive Director
Pursuant to Government Code § 54957.6:UPDATE ON LABOR NEGOTIATIONS
Negotiators: Jay Kelekian, Rent Stabilization Board Executive DirectorEmployee Organizations: SEIU Local 1021, Community Services and Part-Time Recreation Leaders Association, and Public Employees Local 1
After the Board's return from Closed Session, Chair Stephens announced that the Board approved the Executive Director's Evaluation by a 7-0-0-2 vote. ABSENT: Drake, Harr.
9. Adjournment


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Welcome to our blog. Excitement has filled the entire room as the first word, of the first sentence, of our first blog is typed! This lace.and.lilies blog has been nothing more than a simple thought. A thought supported by positivity, color, dreams and all things flowers. We are tingling with anticipation to watch it come to life, take form and blossom into something bigger than us. Kind of like lace.and.lilies.
It now feels appropriate to give you our story, a modern day fairytale … you may ask "why modern?" Well, there is no prince charming in this fairytale, just two girls full of love and life and a new business that fuels our creative spirit.
Lisa, the epitome of an artist. Born and raised in the small town of Findlay, Ohio. One older and inspiring sister, two parents who always encourage dreams, no matter how big they may seem. When not riding a Unicycle, Lisa can be seen moving to the beat of her own drum. Lisa's real adventure began when she attended FIDM in Los Angeles, California. Patterns, fabrics, sewing, sketching, and creating from the world around her. She found herself in Colorado, beginning a beautiful journey.
Lacey, full of passion. Born and raised in a loving, Midwest family of five. Parents who taught her to never quit and always do the right thing and two older brothers who challenged her everyday and protected her life with theirs. Whether it was sports, friendships or art, Lacey's passion has always been bursting at the seams. A believer in following her heart all over the world, she planted herself in Colorado. Living everyday like it is America's Funniest Home Videos, Lacey is ready for what is coming next.
When our lives collided, a business and everlasting friendship began. We laugh, cry, create, love, live and remain true to who we are as artists. lace.and.lilies is more than a floral design business; it is us. Not a moment goes by that we are not contributing all we have to give to this business. We live for our brides and clients, making sure we are giving them their dreams through flowers. Our journey is precious and we are full of gratitude for this opportunity.
Welcome to our journey. Keep an open mind. Let our words jump off the page and inspire you. Learn something new. Feel something old. Dream something big. And come see the world through our eyes. It is colorful and full of magic just like a modern day fairytale.


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If there was a thing such as a perfect Traverse City wedding, Christine and Joel's nuptials would be it. The ceremony took place un the sun under Building 50 and transitioned to a beautiful outdoor cocktail hour at the Botanic Garden. From there, guests were ushered into the reception with champagne and wowed with the incredible decor inside the Cathedral Barn. Don't miss their exceptionally sweet pup, Louie, and the helicopter exit from the ceremony!
Wedding Planning, Coordination & Styling: Sincerely, Ginger Weddings/ Photography: Weber Photography/ Venue:Cathedral Barn & Botanic Garden/ Floral Design: Boom Floral design / DJs: Cage & Aquarium, Levi Britton & Festival Strings / Catering: The Cooks house / Stationary: Silver Fox Calligraphy & Holly Thomas Design