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- Former E! red carpet producer Aileen Gram-Moreno claims she was fired for allowing celebrities to share their support for Catt Sadler.
- Catt Sadler spoke out following the producer's termination, "It's disappointing that any network would order the censorship of opinions."
- E! addressed the situation, claiming Gram-Moreno was asked not to return "due to job performance issues."
Aileen Gram-Moreno, a red carpet producer, filed a complaint with the Equal Opportunity Employment Commission for, she claims, being fired by E! for allowing celebrities to share their support for Catt Sadler. She had resigned from her position at E! when she discovered that her male co-host was making far more than her. Now Catt herself is weighing in on the producer's plight. "It's disappointing that any network would order the censorship of opinions," she told Variety. "But it's particularly disturbing in this case because we are at a cultural tipping point where women feel more and more comfortable being vocal about issues like pay equality and sexual misconduct. To shut down those conversations is to stifle progress."
While on the red carpet at the 2018 Golden Globes, Eva Longoria, 42, shared her support for Catt following her departure. "We're also here for Time's Up," the actress said. "We support gender equity and equal pay and we hope that E! follows that lead with Catt as well. We stand with you, Catt." Gram-Moreno spoke with The New York Times on March 2 about how she attempted to handle the situation in light of a particular mandate from her employer. "They said, if there's any mention of Catt in the preshow, make sure you flag it," she said. "You're censoring celebrities; it's just not a good idea in my humble opinion. But it wasn't my decision." Clearly, comments involving Catt did air during the broadcast. See all the stunning looks from the 2018 Golden Globes red carpet here.
E! addressed Gram-Moreno's firing in a statement to Deadline: "For the past decade Aileen Gram-Moreno was a freelancer who worked an average of 20 days per year solely for our red carpet coverage. After the Golden Globes, she was asked not to return due to job performance issues. Following an attempt to force E! to pay for her silence Ms. Moreno is now spreading misleading and inaccurate information."
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The Parenting Advice Website For The Christian Working Mom
Estimated Reading Time: 5 Minutes
I Was Overly Anxious During My Pregnancy…
I read countless books, looked up reviews on every baby item out there, and read forums that made me paranoid beyond belief.
By the time I was about to deliver Izaak, I felt ready. Like I knew everything about being a mother after spending the last nine months researching. Damn was I wrong.
Books Don't Teach You What Being A Mom Means
There are many things I had to learn about parenting as they happened. But, I was never on my own. I had my husband, and most importantly God by my side every challenging step of the way. Sometimes I feel like God was carrying me until I could get back up.
One of the hardest challenges I had to overcome in motherhood was learning how understand my high-energy child. I read articles about high-energy children because based on my family history that there was a chance my child would have A LOT OF ENERGY.
However, I wish the books would have warned me that grown ass adults would call my kid naughty, even though he is simply busy. I've learned over time that I know my child better than anyone else. He's one of the sweetest human beings I know, and he's definitely nice (Santa thinks so too!).
I wish online articles from experts would have warned me that the first day my son would go to daycare would be one of the hardest days of my life, and that it was normal for me to worry.
Parenting books never explained the guilt I would have when making a mistake that would affect my son negatively. I never knew that I would be mad at myself often for the countless mistakes I made and continue to make in front of my child.
Read About Making Memories With Your Children
The books did tell me that my son would make milestones and at what age, but they never told me how how proud I would be when I heard Izaak say his first word, or count to thirty (Even though he always missed the number sixteen.).
I Did Not Prepare Myself For Postpartum Depression.
I actually never read any books on the subject, because I never thought I would experience it.
I wasn't expecting postpartum because I had the most amazing child in the world that I love more than anything else, and I knew that even when he was in my belly. But after I birthed Izaak I was depressed and constantly anxious. I It was hard to be happy.
To be honest, at times I missed my self-centered lifestyle. No one told me THAT would happen. They just said "Enjoy time to yourself while you can.".
I wish I would have taken the time to prepare myself emotionally. It wasn't just important for me to learn what I could about raising a child, I should have realized that it was also important to make sure I knew how to take care of myself postpartum.
I was told by the books how tired I would be the first few months of my son's life when he didn't sleep through the night.
However, I was never warned how lack of sleep would affect my husband's and I's relationship. Or how we were drawn closer together as we became more familiar as parents. We got through it just fine, in fact we are now better people and closer to each other.
You see, just as women are tough enough to give birth, they are also strong enough to endure the trials of motherhood. Being a mom is hard (and being a mom never ends), but God gives us basic instincts and strong wills to get through trials that words cannot describe. God is with us, and no matter what season it is, we will be OK. Having a family is an amazing blessing. Going through everything together as husband and wife creates a bond that nothing can break.
There are many working parts that go into being a mom. Motherhood is still a struggle for me but what matters always is knowing that it's WORTH IT. I love being a Christian, wife and mom. Nothing will ever change that for me. If I'm blessed enough someday I hope I am that mom who always wants to visit her kids and grandkids and bring cookies. For some reason that sounds exciting to me. Being a mom is hard, being a mom never ends, but more importantly, being a mommy is the best!
Related Blog Post: 3 Lessons From 15 Years Of Parenting written by AnarchoMommy
-Holly, the imperfect momma.


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Career Services Moves to Paton House
November 11, 201785 Views
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Career services is expected to move to Paton House by January 2018 in order to make traveling to their office more convenient for students.
Career services currently has two offices: one in the Kessel Student Center with one counselor Monday through Thursday from 12:30-2:00 and an office at the Gannett House which has the entire team of career services counselors, which is Monday through Friday 9:00-5:00.
Although Career Services have an office with one counselor at Kessel Student Center, they believe that students can benefit more from the help of the entire team of counselors.
"Now that our department is moving, each counselor and each school can have their own walk-in hours instead of just one. This will make Career Services more accessible to students," said Bless Vaidian, the Director of Career Counseling.
Career Services actively works to get students to be more involved in their programs so they can be ready to be hired, however, students have raised concerns about career services being too far for them to walk to.
"I want to go to Career Services, but it's so far of a walk. By the time I'm out of class and done with whatever I need to do for the day, I don't want to walk back up that hill just to go to a workshop," said Jacob Souders, a junior.
After Career Services officially moves, there are going to be a few major changes to their programs. They're going to have their workshops based in Paton House, events on site, and on-campus interviews.
"Most of our workshops happen in the Mortola Library or Kessel and our on-campus interviews take place at the Goldstein Academic Center, so it can get a little confusing for students to keep track of where we are next," said Vaidian.
Ultimately, the goal for Career Services is to have make it more convenient for students to feel motivated to participate in their workshops and to start going sooner in their college careers, rather than later.
"I didn't start going until late last year and now I'm a senior and I feel like I'm still not completely ready for a real job. I knew I needed to go to them sooner, but I was too busy throughout the semester to walk there," said TJ Combs, a senior.
Career Services has been active on social media in order to raise the student's interest in their programs and to inform them of the new workshops and events that are happening on a daily basis.
" I don't check my phone all the time but I'm at that point in my college career where I need to start checking the Career Services account on Instagram to make sure I'm not missing anything important or any opportunities because I got too lazy to check," said Kaila Williams, a junior.
My name is Adiba Sikder and I'm a senior double majoring in digital journalism and digital cinema and filmmaking. I've always valued stories and storytelling....


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Archaikomely Chocolate Hair Color With Highlights
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Lovely Madison Reed Hair Color Reviews Makeupalley
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Uk Caramel Hair Color With Blonde Highlights
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West Side Story is a Masterpiece. No two ways about it.
Leonard Bernstein, who was the composer of the music of West Side Story, (Stephen Sondheim wrote the lyrics) and also the most famous Music Director ever of the New York Philharmonic, was, as all proper artists are, a tortured soul. His loyalties were split between so many polar opposites: – popular music / classical music – composing / performing – American / European Arts – the whole human race / the Jewish people – heterosexual / gay. In all these areas he was a bridge-builder, or at least a valiant pioneer striving to unify the possibly incompatible.
Much of the music he composed, especially later in life, has a rather self-conscious earnestness about it, a desire to be serious and respectable, coupled with a need not to be snobby or aloof. And sometimes that can make for an awkward compromise, a voice that is neither quite one thing nor the other. But in West Side Story, he hit the vein of gold. Perhaps it was the book, with all the tribal tensions he knew so well, but in a form distanced from his own Jewish identity. Perhaps it was the condition of Broadway at that moment – ready for something a little more sophisticated than a run-of-the-mill love story, but not yet overtaken by the mindless pap of more recent years. Perhaps it was its place in the trajectory of his own life, - an increasingly accomplished serious musician immersed in the world of the Boston Symphony Orchestra and many of the great musicians of the world, but not yet weighed down by the responsibilities of heading the nation's oldest orchestra, the New York Philharmonic.
Leonard Bernstein went on to be a formative influence in the musical awakening of untold young people, (and older ones too) through his magical Young People's Concerts with the NY Philharmonic. I have never forgotten seeing one of these presentations myself when the New York Philharmonic was on tour in Manchester, England. It was riveting, and I remember the program in every detail. (A tiny personal note: the concertmaster of the New York Philharmonic that day was Frank Gullino, whom I came to know very well as a close personal friend when he retired to be Concertmaster of the New Orleans Symphony throughout the years when I was Associate Conductor there. No-one prepared a better pasta or offered a finer Manhattan. He played the fiddle quite well, too.)
It was Leonard Bernstein who conducted Beethoven's 9th in East Berlin just after the infamous wall came down in 1989. He delivered wonderful, and controversial, lectures at Harvard University on the structure of music, seen through the perspective of Noam Chomsky's linguistics.
I am not trying to make him out to be even more of a heavyweight than he was, I am just trying to describe the breadth of his achievement and talent. For he was also a showman unmatched. He would leap and yearn and weep on the podium in an almost bizarre, and certainly unique, manner. Whereas Fritz Reiner, with the Chicago Symphony, was famous for hardly twitching an eyebrow, Bernstein would break his own heart and weep publicly, on cue, on contract.
And in composing West Side Story, all this passion, showmanship, vitality, and expertise came together as never before, and as never again. At that point in time, 1957, Bernstein was able to write music in an American idiom, on an American plot set in New York City, for that especially American medium; the musical. Like so many great works, it was successful; but not instantly recognized as the classic it became. That year, it lost out in the Tony contest to "The Music Man", but there has hardly been a Broadway Show more quoted, transcribed, adapted, than West Side Story. Songs such as Tonight, Somewhere, Maria, I feel Pretty, America, One Hand One Heart; all of these have become staples of the repertoire in their own right, whether or not they are connected to West Side Story on any given evening.
The theaters of Broadway do not have large pits, so the bands that play the music for musicals are generally quite small. Certainly small compared to a symphony orchestra. The band for West Side Story was unusually large, needing 30 players. But 30 players is much smaller than a symphony orchestra. So when it comes to concerts such as those of the Vermont Symphony this summer, it is generally an arrangement for the purpose that is used. That is the case in our concerts, but it in no way weakens the music. In fact, the full power of the symphony orchestra more than compensates for the absence of a stage with actor/singers. After all, the "classical" in classical music just means music that has stood the test of time, and come to be regarded as indispensable, central to the whole activity of music. West Side Story qualifies in every way as a classic in that sense.
Andrew Massey
Thursday, June 14, 2007
West Side Story
West Side Story is a Masterpiece. No two ways about it.


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Ambitious UK pop singer blazes a path all over the map
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How great would these glamorous rhinestones look on your DIY stenciled pillow? These beautiful flat back,18mm rhinestones are easy to attach to your accent pillow with our Fabric Fusion Glue (sold separately) and are sold 9 to a pack. A designer toss pillow is sure to get your attention when decked out in these flashy rhinestones!


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Led by event chairs Martha Grimm, Lisa Hayes Jankowski & Darcy Weber, the annual event includes dozens of vendors from throughout the U.S., offering items ranging from jewelry and fashion accessories to high-end clothing and eclectic home décor. It also includes a Trifles & Treasures area of gently used items, which has become one of the most popular offerings of the annual event that draws crowds from throughout Palm Beach County and surrounding coastal communities. The show opens with a VIP party on February 18. At $100 per person, it includes an evening of shopping, hors d'oeuvres, cocktails, and free valet parking. The boutique continues February 19-21 from 10 a.m. to 4 p.m. at a cost of $5 per person.
"We are extremely grateful to all who contribute to the success of this event. It provides substantial funds that help us continue our work with women who struggle with addiction. It is a cause that touches so many families and we are able to make a difference for many of them as a result of this event," said Lisa McWhorter, Wayside House's chief executive officer. Wayside House was established in 1974 by Dr. Susan B. Anthony, great niece and namesake of the women's rights activist and by Phyllis Michelfelder to provide alcoholism services to women. The center now serves women ages 18 and older suffering from drug and alcohol issues and accompanying disorders. The traditional and innovative therapies are now supplemented with equine, art and horticulture therapies, as well as yoga, parenting and job-skills training.
For more information or to register for the Preview Party and organization go to www.waysidehouse.net or contact Rhett Toth at firstname.lastname@example.com


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Speaker: Catherine Flick
Dr. Catherine Flick is a reader in computing and social responsibility at the Centre for Computing and Social Responsibility at DMU. She graduated with a BSc (1st class honours) with majors in Computer Science and History & Philosophy of Science from Sydney University, Australia, while working in industry as a systems administrator and web programmer, and a PhD in Computer Ethics from Charles Sturt University, Australia, with a thesis on informed consent and ICT. Areas of research have involved responsible research and innovation in health technologies and cyber security, online child protection, trusted computing, ethics and video games, anonymous technologies and the darknet, and informed consent in ICT. She is a Fellow of the Higher Education Academy with a PGCHE. She is a member of the ACM's Committee on Professional Ethics, and is a committee member of the ACM's Code of Ethics update team. She is currently work package leader for the European funded projects COMPASS and Living Innovation, which look at integrating ethics and responsible innovation into SME and large company business practices, and has a long history of working on European projects in this area. In addition, she teaches research methods and computer ethics, and hosts a podcast on ethics and video games called "Not Just A Game".
Find Catherine Flick at
Last Year's Tracks
Monday, 4 March
Advances in FinTech
Finance is king in London. What's happening and what should you be paying attention to with modern #FinTech
Surviving Uncertainty: GDPR, Brexit, or Politics? Beyond DR
With so much uncertainty, how do you bulkhead your organization and technology choices? Learn strategies for dealing with uncertainty today.
Architectures You've Always Wondered About
Ever wondered how they do it? Next-gen architectures from the most admired companies in software, such as Netflix, Google, BBC, Twitter, & more.
Evolving Java & the JVM
6 month cadence, cloud-native deployments, scale, Graal, Kotlin, and beyond. Learn how the role of Java and the JVM is evolving.
AI/Machine Learning without a PhD
AI/ML is more approachable than ever. Discover how deep learning and ML is being used in practice. Topics include: TensorFlow, TPUs, Keras, PyTorch, & more. No PhD required.
Modern Operating Systems
Decompose the modern operating system, LinuxKit, Containers, Unikernals, eBPF, and more.
Tuesday, 5 March
Bare Knuckle Performance
Killing latency and getting the most out of your hardware.
Operationalizing Microservices: Design, Deliver, Operate
What's the last mile for deploying your service? Learn techniques from the world's most innovative shops on operating microservices.
The Right Language for the Job
We're polyglot developers. Learn languages that excel at very specific tasks and remove the undifferentiated heavy lifting in their specific domain.
Security Transformation
How do you actually start with a security mindset? Learn techniques for making security a first-class concern.
DevOps & DevEx: Remove Friction, Ship Code, Add Value
Remove developer friction: CI/CD, fluent API, service meshes... anything that removes the friction in deploying & operating a system.
"Don't Mess Up The Culture!"—Scaling with Sanity
Culture is simply a shared way of doing something with passion. How do you maintain the culture as you scale?
Wednesday, 6 March
Architecting for Failure: Chaos, Complexity, and Resilience
Making systems resilient involves people and tech. Learn about strategies being used from chaos testing to distributed system clustering.
JavaScript: Powering the Modern Web
Explore the frameworks that make JavaScript so popular, and learn how JavaScript-based languages are revolutionizing frontend (and backend) development.
Modern CS in the Real World
Rediscover CS in this applied track on how research is affecting software today.
Career Hacking
Strategies for advancing the skills that advance your career. Look for mentoring, speaking, empathy, and career paths.
Tech Ethics: The Intersection of Human Welfare & STEM
What does it mean to be ethical in software? Hear how the discussion is evolving and what is being said in ethics today.
Architecting for the Cloud / Streaming Architectures
Cloud native architectures is a reality. Hear the war stories. learn the benefits, and dodge some of the pitfalls of running on the cloud.


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Share the road
"At the end of the day, we're all just walking each other home."
Anne Lamott, one of my favorite writers, first introduced me to this quote, taken from author Ram Dass, and I've been thinking a lot about it these past several days in the aftermath of Hurricane Harvey.
On the heels of one of the ugliest episodes in recent history, the hate-filled Klan march in Charlottesville, we've seen Americans rushing in to help in Houston without any obstructing filters – color-blind, gender-blind, class-blind.
We've seen the images and heard the stories, heroic rescues by neighbors with boats, folks traveling from hundreds of miles away to lend a hand and help rebuild, countless others asking for ways to contribute.
We saw them after Katrina, after 9/11.
Why is it that only after catastrophe strikes do we look into the eyes of others and recognize our own shared humanity?
Why is it that so many of us rush in to save another who, on a different day, may be the subject of our derision and contempt?
Some of those rescuers, I dare say, could just as easily have been supporters of what happened in Charlottesville.
What turns decent people into angry, hate-filled marchers, intent on violence?
There's been plenty of ugliness in this country this past year, whipped up by fear- and hate- and anger-mongering by the powers that be in Washington, tearing into the moral fabric of this country.
And now we have the Dreamers.
A nuclear crisis is looming in North Korea, another devastating hurricane is headed toward Florida, the healthcare system has been sabotaged, the federal government is facing a shutdown, the west coast is burning.
That's more than plenty on the plates of our leaders, and yet yesterday – with no approaching deadline or imminent threat – the president and his attorney general took the time to serve eviction notices on hundreds of thousands of would-be proud Americans.
In 2012, our government told the young and undocumented who came to this country as children that if they came out of the shadows, identified themselves and lived here as do other law-abiding citizens, they'd be protected under the law.
Scores of them did that, holding up their side of that promise. They attended school, learned the language, obeyed the law, went to work, served in the military, contributed to their communities and proudly behaved like citizens, more so than some who think just waving a flag is enough.
Yesterday though the president and Attorney General Jeff Sessions -- under the guise of passing the buck to Congress -- announced that we were reneging on that bargain, telling those dreamers that in a few months they'd no longer belong here.
Yes they do, Mr. Sessions, yes they do – just as much as do you, your ancestors and anyone else who came to this country with little more than the dream of America in their pockets and the promise of protection under the law.
This is and has been their home too, and at the end of the day, we're all just walking each other there.
Maybe it's a longer walk for some. And maybe it takes others longer to get on that road.


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This bourbon cocktail from Opal in Portland's Dossier Hotel is sublimely smooth and warming through and through.
1½ oz. Buffalo Trace bourbon
½ oz. Aperol
¼ oz. Amaro Montenegro
2 dashes Regan's Orange Bitters
2 dashes Angostura Bitters
Tools: barspoon
Glass: rocks
Garnish: orange peel
Stir all of the ingredients together in a mixing glass with ice. Strain into a rocks glass over a single large ice cube. Garnish.
Lightning Bar Collective for Opal, Portland, Oregon
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I have teetered back and forth, regarding the public viewing of this very personal and sometimes emotional blog. It is a very vulnerable thing, to bare my soul and to allow people to see into my deepest of thoughts. I have spent most of my life guarded, shutting people out. It is sometimes overwhelming and often times scary, letting people into very intimate details of my mind. They're private thoughts, that only God and I share. It is quite intimidating, sharing these thoughts with you, especially after visiting and reading some of your blogs. I find each one to be unique in their own special way.
Some of you are incredible story tellers. I am in awe of your vivid imagination and keen ability to write in grave detail, descriptions of vast characters, residing in exciting new places. It is obvious that most of you are well educated. Your knowledge of an elite vocabulary is extremely prominent in your writing. Your words are exquisite. Your placings of commas and semi colons are precise. Reading your blogs are much like reading a poem or sonnet. Your thoughts are wonderfully expressed and breathtakingly beautiful.
Equally so, are the blogs of talented artists. Instead of using words, you use drawings, sketches, or comic book humor. I find your blogs most intriguing. Your ability to express emotions visually, with the use of little to no words, is extraordinary and sometimes even humbling. I love seeing your perspectives on life and envy your talent.
You are each an inspiration and have touched my heart in ways only some of you can understand.
Earlier this week, someone posted a blog on what they thought a writer was and should be. His description resonated negativity and to be honest, so does much of his posts. I immediately began doubting my blog and wondered if it was even good enough to share. I have no experience with the blogging world and have only 2 semesters of college, which is the extent of my schooling. I dropped out to take care of my twin toddlers, who demanded and rightly deserved most of my attention. I am just your average, self educated, single mother, who stumbled upon a passion for writing.
My talent does not exceed or even compare to some of you, but the desire to express myself through written words is my form of therapy. I find it hard to speak the words I write, but when they're on paper, it comes naturally and with ease. My mind is a jigsaw puzzle. Its pieces are complicated. There are too many thoughts, to break them down into intelligent conversation, but if I write them down, the pieces come together, to articulate the very thing I was hoping to say.
I am an informal scribbler of thoughts and emotions. So therefore, I am a writer. I write of my anger, I write of my fears, I write of my gloom, as well as my happiness. I am the author of my own personal masterpiece. I am the rough draft of an incomplete story, with the promise of becoming a best selling novel, if to no one but myself.
So in response to this writer, I want MY words to make a difference and to inspire. If you're not writing to inspire, then why write the story?


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Client: NTMA, 1 Dublin Landings Architect: ARROW and RKD Developer: Ballymore and Oxley Location: North Wall Quay, Dublin 1
Client: NTMA, 1 Dublin Landings
Architect: ARROW RKD
Developer: Ballymore and Oxley
Location: Grafton Street – Dublin 2
Dublin Landings is a unique and breathtaking development with striking architecture inspired by Ireland's coast and robust woodlands, integrating rugged landscape with contemporary architecture.
The NTMA (National Treasury Management Agency) will occupy 1 Dublin Landings a building with generous height reception halls opening to large atria and the main lift lobbies. Filled with daylight, this building won't rely only on light from artificial sources.
Sitting on the North Wall Quay, within Dublin's financial and technology district, Dublin Landings' emergence as the new commercial heart of the Irish capital is being underwritten by the calibre of occupants such as the Central Bank of Ireland, whose new headquarters is here.
The overall development will include 65,000 sqm of flexible Grade A office and retail space, with five office buildings due to be completed by 2020.
Allied Ireland was contracted to design and develop the atrium in conjunction with our manufacturers Exova Warrington (patent pending) to glaze the spectacular full height 11 story central atrium which floods each floor with natural light from the core of the building.
On the ground floor Allied designed bespoke 4 meter floor to ceiling toughened glazing, for the floors above toughened laminated glass was used. On the upper levels Allied installed glass with an EI 30/30 fire rating that is cabable of withstanding up to a 1.5kN load.
All glazing has a clear, translucent silicone joint
Do you need advice on your new project?
Request a call back and let us help you.
Keep in touch.


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Mini Review ARTICLE
Targeting SOX2 as a Therapeutic Strategy in Glioblastoma
- 1Cellular Oncology Group, Department of Oncology, Biodonostia Institute, San Sebastian, Spain
- 2IKERBASQUE Foundation, Bilbao, Spain
- 3Opioid Research Group, Department of Pharmaceutical Chemistry, University of Innsbruck, Innsbruck, Austria
- 4Neuro-Oncology Committee, Donostia Hospital, San Sebastian, Spain
Glioblastoma is the most common and malignant brain cancer in adults. Current therapy consisting of surgery followed by radiation and temozolomide has a moderate success rate and the tumor reappears. Among the features that a cancer cell must have to survive the therapeutic treatment and reconstitute the tumor is the ability of self-renewal. Therefore, it is vital to identify the molecular mechanisms that regulate this activity. Sex-determining region Y (SRY)-box 2 (SOX2) is a transcription factor whose activity has been associated with the maintenance of the undifferentiated state of cancer stem cells in several tissues, including the brain. Several groups have detected increased SOX2 levels in biopsies of glioblastoma patients, with the highest levels associated with poor outcome. Therefore, SOX2 silencing might be a novel therapeutic approach to combat cancer and particularly brain tumors. In this review, we will summarize the current knowledge about SOX2 in glioblastoma and recapitulate several strategies that have recently been described targeting SOX2 in this malignancy.
Sex-determining region Y (SRY)-box (SOX) factors are a family of transcriptional regulators that carry out important functions during embryonic development and which are key components for the maintenance of the stem cells in adult tissues. This family of transcription factors is characterized by a conserved high mobility group (HMG) DNA-binding domain and is composed of 20 members divided into 8 groups (from A to H), based on their HMG sequence identity (1). Members within a subfamily conserve at least 80% identity in their HMG-domain, in addition to sharing other well-conserved regions. Moreover, members from the same group might have overlapping expression patterns, share biochemical properties, and perform synergistic or redundant functions. By contrast, members from different subgroups usually develop different functions (2).
SOX2 is a member of the SOXB1 group (together with SOX1 and SOX3), which is required for the maintenance of the embryo before implantation. SOX2 has a role in cell fate and maintenance of the progenitors's identity during embryogenesis. It is also important for tissue homeostasis and regeneration by maintaining stem cell activity in several compartments, particularly in the central nervous system (CNS), in adults (3). During recent years, several studies have demonstrated the impact of SOX2 deregulation in a wide variety of human diseases. A heterozygous inactivation of SOX2 causes syndromic microphthalmia-3 (MCOPS3), a genetic disease characterized by anophthalmia, microphthalmia mild hypopituitarism, and sometimes learning difficulties, convulsions, motor dysfunctions, and growth problems (4). On the contrary, SOX2 upregulation has been linked to the development and maintenance of several types of cancers (3, 5–7).
Tumors of the CNS form a heterogeneous group of diseases that comprise less than 2% of the total number of cancer cases. Every year in the world, ~350,000 people are diagnosed with gliomas, making it the most common primary brain tumor (8). According to clinical and histopathological characteristics, WHO classified them by four grades of malignancy: pylocitic astrocytoma (grade I); diffuse astrocytoma (grade II); anaplastic astrocytoma (grade III), and glioblastoma multiforme (GBM, grade IV). GBM is the most common, malignant, and lethal glioma subtype in adults accounting for 12–15% of all brain tumors and about 50% of gliomas. The incidence ranges from 1 to 5 cases per 100,000 people per year, with an average patient survival of around 15 months (8). This prognosis identifies this type of tumor as one of the most aggressive and fatal cancers overall. According to the clinical presentation, there are two main GBM subtypes: primary or de novo GBM and secondary GBM. Primary tumors, the most common form, typically appear in older patients without any prior clinical or histological evidence of a lower grade precursor lesion and they have an aggressive clinical course. Secondary tumors are more frequent in younger people and they progress from a previous lower grade glioma with a less aggressive clinical course (9). Genetic and transcriptomic expression studies have allowed a more detailed molecular classification identifying four GBM subtypes: (i) classical, with EGFR amplification and overexpression, CDKN2A and PTEN deletion, NES overexpression and activation of NOTCH and SHH signaling pathways; (ii) mesenchymal, with loss of NF1, TP53, and PTEN, overexpression of MET, CHI3L1, CD44, and MERTK, and activation of the TNF and NF-kB pathways; (iii) proneural, with PDGFR amplification, loss or mutation of IDH1, PIK3K, TP53, CDKN2A, and PTEN, and activation of HIF, PI3K, and PDGFR pathways; and (iv) neural, with EGFR amplification and overexpression, and expression of neuronal markers, such as NEFL, SYT1, and/or GABRA1 (10). Different subtypes are associated with variable prognosis and response to therapy, and this heterogeneity and this therapy resistance are likely the main characteristics responsible for the glioblastoma patients' dismal outcome.
The cancer stem cell (CSC) theory postulates a hierarchically organized system in opposition to the stochastic model of tumor growth. The CSC model suggests that only a small group of cells have quiescence and self-renewal capacity within the tumor bulk, and that those are responsible for tumor maintenance and recurrence (11). Nowadays, there is a lot of evidence that supports the existence of CSCs in GBM, called glioma stem cells (GSC), and their relevance in the etiology of GBM. Several groups have been able to isolate GSCs from patient-derived tumors and multiple experimental data have shown that these cells are responsible for glioblastoma initiation and maintenance (12, 13), as well as for recurrence and chemoresistance (14–16). Moreover, there are different explanations for their origin. One of them proposes that neural stem cells (NSCs) undergo malignant transformation while retaining stem cell features. Indeed, inactivation of TP53, INK4a/ARF locus, PTEN, and NF1 tumor suppressors or activation of EGFR/PDGFR/PI3K oncogenic pathways in NSCs induces high-grade gliomas (17). Similarly, transient amplifying progenitors have been also shown as GSCs and the cell of origin of GBM (18). Another theory claims that more mature or differentiated cells are reprogrammed and form GSCs and high-grade gliomas. Indeed, several mutations in astrocytes, oligodendrocyte progenitors, or in neurons are sufficient to confer stem cell properties during neoplastic transformation (19, 20). Therefore, in order to establish efficient treatments that can induce a long-lasting clinical response in GBM, it is important to develop strategies that can specifically target GSCs (Figure 1A). CSCs, including GSCs, achieve self-renewal through asymmetric division, in which one daughter cell retains the self-renewal ability, and the other is directed to differentiation. Moreover, heterogeneous tumor cell populations and their respective cell division mode have been shown to confer differential sensitivity to therapy in brain tumors (21). Therefore, modulation of asymmetric and symmetric division of GSCs may provide novel strategies for targeting differentially the GSC and the bulk tumor mass. Several drugs and approaches have been postulated (22) to directly target the GSCs population and/or the molecular mechanisms underlying their regulation. In this review, we focused our attention on targeting SOX2 gene.
Figure 1. Significance of glioma stem cells (GSCs) and SOX2 targeting in the recurrence of glioblastoma. (A) Glioblastoma is a heterogeneous tumor composed of GSCs (in red, chemo-, and radiotherapy resistant) and of differentiated tumor cells (in blue, chemo-, and radiotherapy responsive). GSCs need to be targeted before current standard approaches to achieve tumor regression. TMZ, temozolomide; RT, radiotherapy. (B) In order to avoid tumor recurrence, genetic, epigenetic, and pharmacological approaches targeting GSCs expressing high levels of SOX2 have been postulated.
SOX2 Activity and GBM
Several studies have identified an overexpression of SOX2 in GBM patient samples. It was first found elevated in 90% of human biopsies studied at the mRNA and protein level in 2007. This research also showed that SOX2 expression was restricted to the nucleus (23). Since then, overexpression of SOX2 (with varying percentages of positive cases) was observed in several different and independent cohorts (16, 24–27). Importantly, high levels of SOX2 have been associated with tumor aggressiveness and worse prognosis (28, 29). Moreover, several groups, including ours, identified SOX2 enrichment in the undifferentiated GSC populations and demonstrated that SOX2 possesses an important role in the maintenance of GSCs. Indeed, downregulation of SOX2 through RNA interference strategies in GSCs impairs proliferation and their ability to form tumors in vivo (25, 30–32). Additionally, silencing of SOX2 leads to reduced migration and invasion capabilities (25, 33), while it increases senescence and produces an arrest of the cell cycle in G0/G1 (16, 34). The impact of SOX2 in glioblastoma cells has been further substantiated with overexpression studies. Indeed, ectopic elevation of SOX2 increases the capacity of invasion and migration (25), in addition to cell proliferation and self-renewal activity in conventional glioma cell lines (16). In agreement with this last function, SOX2 is one of the transcription factors, together with POU3F2, OLIG2, and SALL2, which is sufficient to reprogram differentiated glioma cells into induced GSCs, similar to GSCs obtained from human biopsies (35). Altogether these data show that glioma cells have a dependence on SOX2 to maintain their tumorigenic activity with GSCs displaying high levels of SOX2. They also demonstrate that SOX2 possesses an important role in the maintenance of GSCs.
In regard to a putative role of SOX2 controlling cell division modes, a recent work showed that the inhibition of the FACT chaperone complex in GSCs promotes their asymmetrical division in a process that involves SOX2 downregulation (36). In line with these results, other authors found that the knockdown of HMGA1, a chromatin structure regulator, not only in GSCs but also in colon CSCs, induces an asymmetric division together with a decrease in SOX2 expression (37, 38). These works suggest that SOX2 action in the maintenance of undifferentiated GSCs could rely on effects promoting symmetrical in addition to the expected asymmetrical division. Importantly, these results support a hierarchical model of glioma cells controlled by SOX2 expression, which brings up the idea to target SOX2 or to find downstream targetable genes as a strategy to eliminate GSCs and subsequently the tumor.
Upstream Regulation of SOX2
The regulation of SOX2 is a complex network of transcriptional, post-transcriptional, and post-translational regulators (Table 1). Some of these regulators are altered in GBM and lead to the overexpression of SOX2. Four main signaling pathways are involved in SOX2 expression, including TGF-β, SHH, EGFR, and FGFR. All these signaling pathways are aberrantly activated in GBM, which leads to the maintenance of the tumor at least in part through SOX2 factor overexpression. The inhibition of TGF-β signaling decreases the tumorigenicity of GSCs by the suppression of SOX2 activity (31). SOX2 function is also mediated by other members of the SOX family, such as SOX4, acting downstream of the TGF-β signaling pathway, and forming a complex with OCT4 at the SOX2 promoter (31, 39). SHH pathway is initiated with the binding of SHH ligand to PTCH receptor, causing the activation of SMO. Active SMO will activate GLI1/2, which then translocates into the nucleus and activates SOX2. The regulation of SOX2 by SHH occurs in neural and brain stem cells (40, 41), and the pharmacological inhibition of these pathways silences SOX2 expression and impairs glioma cells' tumorigenic activity (16). The FGFR pathway regulates SOX2 expression through two main signaling cascades: (i) MEK/ERK and (ii) PI3K/AKT/mTOR, two signaling pathways activated in GBM, and whose suppression leads to the inhibition of tumorigenesis and self-renewal of GSCs (42). The MEK/ERK pathway regulates the expression of SOX2 through the final phosphorylation of ERK, which translocates into the nucleus and activates the transcription of SOX2. The PI3K/AKT/mTOR pathway regulates positively the expression of SOX2 through the activation of the mammalian target of rapamycin complex 1 (mTORC1). The inhibition of mTORC1 by rapamycin in GSCs leads to an inhibition of the SOX2 expression and a decrease in self-renewal activity (16). SOX2 is also regulated by EGFRvIII, a frequent mutant in GBM that leads to the activation of pro-oncogenic signaling in GBM. Indeed, the expression of EGFRvIII positively correlates with the expression of SOX2 and is associated with an enhanced self-renewal ability and tumor-initiating activity (43). This correlation has demonstrated that it is carried out by the axis EGFRvIII–STAT3–PEDF–Notch (44).
SOX2 can also be regulated via post-translational modifications, such as ubiquitination, phosphorylation, and acetylation. Acetylation and phosphorylation enhance the export of SOX2 to the cytoplasm and inhibit the ability to bind DNA in embryonic stem cells (45, 46). By contrast, the phosphorylation of SOX2 by AKT stabilizes the protein and enhances the transcriptional activity of SOX2 (47). However, the function of these modifications in GSCs' activity remains elusive.
Additionally, SOX2 genetic amplification and promoter DNA hypomethylation has been identified in a set of GBM patients, further expanding the mechanism responsible for SOX2 upregulation in glioblastoma samples and GSCs (25). Moreover, the regulation of SOX2 through different miRNAs, including miRNA21 or miRNA145, has been described in glioma cells, with this axis having relevant functions in GSCs' activity and in the clinic (29, 48).
Downstream Regulation of SOX2
Several studies have started to characterize downstream targets of SOX2 in glioblastoma. A study of Fang et al. identified SOX2 downstream targets by ChIP-seq and microarray analyses in the LN229 glioma cell line. They found 4,883 SOX2 binding regions in the GBM cancer genome. Moreover, they detected 489 genes whose expression was altered with SOX2 inhibition, including additional SOX family members, cytokines, or BEX members with tumor suppressor activity in glioblastoma. They also identified 105 pre-miRNAs (corresponding to 95 mature miRNAs) that were differentially expressed in SOX2 knockdown glioblastoma cells. Among them, they observed that miRNA145 and SOX2 form a double-negative feedback loop in GBM cells (48), demonstrating that the relationship between SOX2 and miRNA is bidirectional. We have recently observed that several oncogenic SOX2 functions are mediated by SOX9, another member of the SOX family (16), which also carries out important functions in GSC regulation and glioblastoma (26). This regulation occurs at post-transcriptional level (16). Additionally, specific phenotypes associated with SOX2 have been linked to different genes and signaling pathways. Indeed, SOX2-regulated migratory and invasive capacities are mediated by RhoA-dependent pathway and focal adhesion kinase (FAK) signaling, whereas proliferation is mediated by CYCLIN D1 expression (34). WNT signaling pathway, self-renewal, and retinoic acid associated genes are within the genes involved in SOX2-mediated glioma cell plasticity and astrocytic differentiation (49).
Therapeutic Approaches toward SOX2 Reduction in GBM
The current chemotherapeutic agent for newly diagnosed GBM is temozolomide (TMZ), which extends patient survival from 12 to 15 months (50). A role for SOX2 in TMZ chemoresistance has been deciphered during recent years. Thus, cells with elevated SOX2 expression are more resilient to TMZ, whereas its inhibition sensitizes glioma cells to this agent (16). This cellular finding is correlated with clinical information. High levels of SOX2 have been included as a marker of the proneural subtype, which has been shown to be the most resistant subgroup to current therapeutic radio- and chemotherapy treatment (10). The involvement of SOX2 in chemoresistance has been further substantiated through different mechanisms. The inhibition of SOX2 by miRNA145 decreases the chemoresistance of GSCs and increases the sensitivity to radiation and TMZ (51). The overexpression of ID-4 suppresses the expression of miRNA9, that can repress SOX2, leading to an increase in the SOX2 expression. SOX2 induction enhances the ATP-binding cassette (ABC) transporters, ABCC3 and ABCC6, through direct transcriptional regulation. The activation of ABC transporters confers chemoresistance to GSCs (52). These facts together with its prominent role in the regulation of GSCs suggest that SOX2 might be a key responsible factor for resistance to current chemotherapy and postulate that targeting its activity may offer a novel, attractive therapeutic approach to treat glioblastoma patients.
Several strategies are starting to use SOX2 directly or indirectly to target GSCs (Figure 1B). PDGFR signaling has been involved in glioblastoma biology through studies based on analyses of human tumor tissue, cultured glioblastoma cells, and mouse glioblastoma models (22). Similarly, IGF1-R signaling has been described in glioblastoma, and findings from preclinical studies suggest favorable combination effects when IGF1-R inhibitors have been combined with other receptor tyrosine-kinase (RTK)-targeting agents. Interestingly, a combination therapy with PDGF and IGF1 receptor inhibitors (imatinib and NVP-AEW541) produces a significant tumor growth reduction through SOX2 downregulation and GSC sensitization (32).
Rapamycin is an allosteric inhibitor of mTOR, which has been shown to dramatically reduce the self-renewal and tumorigenic activity of glioma cells and GSCs (53). In agreement with these results, several phase I and II clinical trials, with some of its rapalogs, such as everolimus or temsirolimus, alone or in combination, showed radiographic and symptomatic evidence of improvement in delaying tumor progression without provoking high toxicity in patients with newly diagnosed or recurrent glioblastoma (54). It has recently been demonstrated that mTOR regulates the expression of SOX2. Genetic mTOR silencing or pharmacological treatment with rapamycin markedly reduced SOX2 levels in glioma cells (16). Interestingly, the same work showed that the combination of rapamycin and TMZ was more efficient and displayed increased cytotoxicity in cells with high endogenous SOX2 levels (16). Cyclopamine, an inhibitor of the SHH pathway, was also proved effective in reducing SOX2 expression and inducing cytotoxicity in in vitro studies, but unlike rapamycin, its combination with TMZ did not increase the sensitivity of glioma cells to chemotherapy (16). Furthermore, several studies have demonstrated the capability of the GSCs to transdifferentiate into tumor-derived vascular endothelial and mural-like cells in a VEGF-independent manner, making the tumor resistant to anti-vascular therapy (55, 56). This transdifferentiation relies on high levels of NESTIN and CD133 stem markers; however, SOX2 has not been evaluated. It would be of interest to determine the role of SOX2 in transdifferentiation and if knocking down its expression levels is sufficient to prevent the process.
Alternative treatments are arising using SOX2 protein as the principal target of new therapies. Immunotherapy represents a promising treatment option to improve the clinical outcome of patients suffering from GBM. In 2014, Dr Nicolis' group did transplants of GSCs in mice brains using peptide vaccination against SOX2. Peptide vaccination alone increased the mice' survival and the vaccination in combination with the current treatment with TMZ doubled the mice' survival time (41). Before, Schmitz and coworkers identified SOX2 as a glioma-associated antigen abundantly and specifically overexpressed in glioma cells. In addition, they identified an immunogenic HLA-A*0201-restricted T-cell epitope derived from SOX2 that effectively activated tumor-directed cytotoxic T lymphocytes (23). These results highlight the suitability of SOX2 for a novel strategy based in immunotherapy in monotherapy or in combination with current therapies for the treatment of glioblastoma patients.
The use of miRNA delivery could be another therapy linked to SOX2 for cancer cells in the brain. As described above, miRNA145 is associated with SOX2. Interestingly, miRNA145 delivery in GSCs and in xenograft studies in vivo demonstrated the ability to suppress the tumorigenicity by direct downregulation of SOX2 protein with cells becoming more sensitive to chemotherapeutic agents, such as TMZ or cisplatin (51). The promising therapeutic prospect of miR-145 might improve current cancer treatments, especially for those tumors that have developed a resistance to conventional therapeutic methods. However, a note of caution needs to be included since the use of viral vectors for gene delivery may be accompanied by several problems, including an immune response.
Concluding Remarks
Glioblastoma is the most common and malignant adult primary brain tumor with a dismal patient prognosis. It is characterized by presenting significant heterogeneity at the genetic, molecular, cellular, and morphological level, which severely affects clinical practice. Tumor bulk is formed by differentiated cells targetable with chemo- and radiotherapy and GSCs, which need to be eradicated in order to achieve effective therapeutic response.
Sex-determining region Y (SRY)-box 2 transcription factor is important during embryonic development and for the maintenance of stem cell properties of the CNS in adult and aged stages (3, 57, 58). It is also a key regulator of stemness in CSCs and its biological function has been widely described in GBM, associated with stemness activity and a poor clinical outcome (Table 1). Therefore, SOX2 is a strong molecular candidate to be targeted in glioblastoma samples and the potential benefit of SOX2 targeting in the scenario of such a lethal tumor is not negligible. However, a point to take into account with regard to SOX2 targeting for GBM treatment is that other SOX2 expressing cell populations as astrocytes, which develop relevant roles in neurogenesis, could be susceptible to the treatments. The consequences of this must be evaluated and other molecules acting downstream of SOX2, and more specific of GSCs, should be identified and considered as targets.
Transcriptional regulation and/or post-transcriptional suppression of SOX2 through miRNA regulation are promising approaches. There are also encouraging results with SOX2 immunotherapy or combining tyrosine-kinase and IGF1 inhibitors. These results show the preclinical proof of concept that silencing SOX2 activity is an effective strategy in glioblastoma. More solid and extensive preclinical results and clinical trials with the postulated combination of therapies in glioblastoma patients whose biopsies express elevated SOX2 are needed to establish their clinical impact.
Author Contributions
LG-R and IG, first authors of the review, wrote most of the review. NS and AM, senior authors, designed the review, directed the work, and wrote the manuscript. The additional authors suggested ideas and revised the manuscript.
Conflict of Interest Statement
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
LG-R, LM-C, and OA are recipients of a predoctoral fellowship from the Department of Education, Universities and Research of the Basque Government. PA is in receipt of a predoctoral fellowship from the Spanish Association Against Cancer (AECC Gipuzkoa). This work was supported by grants from the Spanish Ministry of Economy and Competition (CP10/00539, PI13/02277) and the European Union (Marie Curie CIG 2012/712404, REFBIO13/BIOD/009 and 011) for AM.
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Keywords: SOX2, glioblastoma, tumor-initiating cells, temozolomide resistance, glioma stem cells, self-renewal inhibition
Citation: Garros-Regulez L, Garcia I, Carrasco-Garcia E, Lantero A, Aldaz P, Moreno-Cugnon L, Arrizabalaga O, Undabeitia J, Torres-Bayona S, Villanua J, Ruiz I, Egaña L, Sampron N and Matheu A (2016) Targeting SOX2 as a Therapeutic Strategy in Glioblastoma. Front. Oncol. 6:222. doi: 10.3389/fonc.2016.00222
Received: 17 August 2016; Accepted: 07 October 2016;
Published: 24 October 2016
Edited by:Sabrina Battista, Consiglio Nazionale delle Ricerche (CNR), Italy
Reviewed by:Eumorphia Remboutsika, BSRC "Alexander Fleming", Greece
Jihye Paik, Weill Cornell Medical Collage, USA
Copyright: © 2016 Garros-Regulez, Garcia, Carrasco-Garcia, Lantero, Aldaz, Moreno-Cugnon, Arrizabalaga, Undabeitia, Torres-Bayona, Villanua, Ruiz, Egaña, Sampron and Matheu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Nicolas Sampron, email@example.com;
Ander Matheu, firstname.lastname@example.com
†Laura Garros-Regulez and Idoia Garcia have contributed equally and should be considered co-first authors.


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Consent Judgments & MCR 3.210
As of January 1, 2015, an amended court rule will finally provide authority to submit a Judgment by Consent. In the past, the court rules only provided for a Default Judgment or a Judgment after an evidentiary hearing with the Judge. This amended rule allows either spouse to present the Judgment of Divorce or Separate Maintenance to the Court after an agreement is reached together for approval by the Judge. The applicable section of MCR 3.210 is as follows:
(E) Consent Judgment.
(1) At a hearing that involves entry of a judgment of divorce, separate maintenance, or annulment under subrule (B)(5)(a), or at any time for all other actions, any party may present to the court for entry a judgment approved as to form and content and signed by all parties and their attorneys of record.
(2) If the court determines that the proposed consent judgment is not in accordance with law, the parties shall submit a modified consent judgment in conformity with the court's ruling within 14 days, or as otherwise directed by the court.
(3) Upon entry of a consent judgment and as provided by MCR 3.203, the moving party must serve a copy of the judgment as entered by the court on all other parties within 7 days after it has been entered and promptly file a proof of service.
This is very exciting news for family law to finally have authority for entry of Consent Judgments which have been submitted to the Court for many years.


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NEW YORK (MarketWatch) -- The dollar jumped against major counterparts on Thursday, after the Federal Reserve delivered a surprise hike in its discount rate after the close of U.S. markets. The dollar index DXY, -0.46%, which measures the U.S. unit against a basket of six major currencies, stood at 80.90 in recent action, compared with 80.38 ahead of the Fed move. The dollar jumped to 91.65 yen, while the euro slumped to $1.3527. The Fed said its 25-basis-point hike of the discount rate to 0.75% was to encourage banks to borrow more from the private market, and cautioned this was not a tightening of its monetary policy. But the dollar's reaction showed the market had another interpretation, according to Kathy Lien, director of currency research at GFT Forex. "Although the Fed went out of their way to say that this does not equate to a change in their monetary policy outlook, action speaks louder than words," she wrote in a note. "The most important takeaway is that the Fed is beginning to implement an exit strategy which is more than what many of the other central banks are doing and therefore this action will be extremely positive for the dollar."
Dollar jumps after Fed hikes discount rate
Quote References
-0.45 -0.46%


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P.E. Web Resources:
Welcome to the physical education web page!
Physical education helps students develop the knowledge, fitness levels, motor skills, and personal and social skills to obtain the ultimate goal of a lifetime of physical activity and health.
All children, from kindergarten through 12th grade, should participate in quality physical education classes every school day.
A quality physical education program should include curriculum aligned instruction and assessment and an opportunity for all to learn.
Kalamazoo Kids Ideas and FUN Activities/ Events for Families
Making Parents Happy! Driven by real moms and dads in the area, our goal is to make you happy.
Let KzooKids help you find things to do with your family in the Greater Kalamazoo
area! Click through the events on our massive events calendar – you'll be amazed at all of the great activities in our region.
Approved Physical Education Grade Level Content Expectations (GLCE)
Click the image below to see approved Physical Education Grade Level Expectations by grade level.
Content Expectations (GLCE)
Healthy Reading for Kids
As a parent and/or caregiver, you do your best to raise healthy and fit children. Here are some books that may help!
Click the image below to find a list of helpful books.
Kids Health
Great resource for parents, students, and educators.


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We provide everything you need including a display boat, experienced shuckers, shaved ice, lemons, various sauces, plates, napkins, and utensils.
We can provide an oyster-only raw bar or we can add in some local littlenecks or shrimp, it's up to you. We work with our customers to make sure they get exactly what they're looking for. We enjoy providing this service and it shows. We hope to join you at your next event!
This is a popular service in the summer months so we recommend booking early. Contact us for pricing and availability: firstname.lastname@example.com


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Think of your heart!
Your heart is important - it's not that hard to keep it happy!
Stress, insufficient exercise, alcohol, tobacco and fast food are all enemies of your heart. The heart is a hollow muscular organ that, when it contracts, pumps blood into the arteries to bring oxygen and nutritional elements to cells in every part of the body. The blood transfers cell waste to the liver, lungs and kidneys where it is processed and eliminated. Everything is clear and straightforward until fatty deposits start building up in the arteries, forming plaques that create blockages and restrict the blood flow through the arteries. That's when the body starts sending out distress signals: heart problems, poor irrigation of the cardiac muscle (myocardium) or the rupture of a blood vessel, leading to a stroke.
Let's look at a few basic principles and identify some preventative foods in our diet. It may be time to give your pantry a make-over!
- fruits and vegetables should make up 25% of your daily diet
- grain-based products (bread, pasta, rice, cereals) should constitute another 25% of your daily food intake
- read labels while grocery shopping to be better informed about the amount of fat in your food
- choose cooking methods that don't require fat but still provide lots of flavour
dark green, like spinach, peppers and broccoli, lettuce
clinical studies have shown that people who eat a lot of boiled potatoes (not fried, or mashed with butter!) are less subject to heart attacks potatoes are high in vitamin C which provides a valuable defense
- orange, like cantaloupe and oranges
- wild fruits and berries, and fruit in general
- lemon, a fat reducer
- nuts, whose oil is beneficial to the arteries - especially almonds
especially whole grain
Cereals and Pasta
preferably brown bread, multi-grain, whole wheat
brown rice is known to play a part in preventing heart disease; accompanied by green vegetables, it can be a defense against heart attacks
- choose lean cuts, whether of beef, pork or lamb, all poultry except duck
- did you know that ostrich is the lowest fat meat you can find?
contrary to what you might think, oily fish can protect you from heart disease
limit your weekly consumption of eggs to two (we're talking about egg yolks - whites can be used as you wish)
Milk and Dairy Products
- choose low-fat milk: skim or 1%
- choose cheese that is partially skimmed, or that contains less than 20% fat
- buy non-fat yogurts and sour cream
Butter, Oil and Dressings
reduce your intake of butter and oil by using non-fat cooking methods, such as roasting or baking, grilling, poaching, etc.
choose vegetable oils low in saturated fats
Olive Oil
olive oil, sunflower oil and sesame oil all belong to a group called phytosterols, which are low in cholesterol and do not form fatty "plaques" on artery walls
cut the oil in your dressings with lemon juice
learn to use spices as a stimulant for your heart: cinnamon, cardamom, curry, coriander, cumin, fennel, galanga, cloves, mustard, allspice, chilies, pepper, saffron
garlic slows down arterial obstruction
learn to use herbs as a stimulant for your heart: chervil, tarragon, fennel, lovage, marjoram, mint, rosemary, sage, thyme, lemon verbena powdered sage is used in Japan to reduce the formation of blood clots and to prevent myocardial problems - it is used as a seasoning or in tea
Cider Vinegar
contributes to normal blood pH, and assists in blood circulation by cleansing and eliminating various toxins and pollutants. It is recommended for eliminating excess cholesterol. It assists in the metabolizing of sugars and equalizes the body's acidity levels.
Red Wine
taken in moderation, red wine has long been recognized in lowering blood pressure and reducing heart attacks. It increases the body's "good" cholesterol level (high in lipoproteins) which in turn attacks "bad" cholesterol (having a low level of lipoproteins); dose: 65 ml of wine per day - it's not much, but it's at this level that wine is therapeutic
MSCOMM has gathered this information from preventative and natural medicine and from the popular traditions of various countries for your information and enjoyment, but MSComm declines all responsibility as to its use and does not intend that it be used as a substitute for conventional medicine.
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