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Obama: 'You are the change'
CHARLOTTE, N.C. — President Barack Obama asked the nation Thursday to choose a "harder" path to long-term economic prosperity, outlining grand economic promises for a second term in office and describing the 2012 election as a vote on the nature of American citizenship.
Obama's acceptance speech at the Democratic National Convention concluded three days of speeches from Democratic leaders, who told voters that their party – and only their party – could be trusted to look out for the interests of the suffering middle class.
Story Continued Below
( Also on POLITICO: Obama's DNC speech text)
And make no mistake, the president and his supporters repeatedly acknowledged that voters are suffering, that the economy is far from fully healed and that the country does not currently sense that it is on the doorstep of a better future.
In a tone that marked a dramatic departure from Obama's last presidential campaign – and from the 2004 convention speech that made him a national political phenomenon – Democrats also argued in the starkest language yet that Republican Mitt Romney is an out of touch plutocrat who lacks simple patriotism.
"America, I never said this journey would be easy, and I won't promise that now," Obama said. "Yes, our path is harder – but it leads to a better place. Yes our road is longer – but we travel it together. We draw strength from our victories, and we learn from our mistakes, but we keep our eyes fixed on that distant horizon."
Obama attempted to strike a balance between connecting with voters in the midst of a protracted economic downturn, and offering an optimistic vision for the future. He has struggled throughout the 2012 campaign to deliver a forward-looking economic vision and break away from a debate focused on an unemployment rate stuck persistently above 8 percent.
( Also on POLITICO: Full coverage of the DNC)
It's too soon to say whether Obama accomplished that goal tonight. At the very least, he coupled an ideological vision for the country with more specific benchmarks for success: a million new manufacturing jobs by the end of 2016; a sharp reduction in oil imports; 600,000 jobs in the natural gas industry; 100,000 new math and science teachers; and new controls on the rising cost of college tuition.
The mechanics of achieving those goals were largely absent from the speech, but Obama said – not for the first time – that he would aim to extract sacrifices from the wealthiest citizens and special interests in order to bring about widely shared economic gains.
Throughout Obama's address and the evening as a whole, there was an undercurrent of America-first triumphalism, and a combination of implicit and explicit charges that Republicans don't share that brand of nationalism.
( PHOTOS: Scenes from the Democratic convention)
"I've signed trade agreements that are helping our companies sell more goods to millions of new customers – goods that are stamped with three proud words: Made in America," Obama said. "Now you have a choice: we can give more tax breaks to corporations that ship jobs overseas, or we can start rewarding companies that open new plants and train new workers and create new jobs here, in the United States of America,"
Obama took time in his speech to mock his challengers and question their readiness for the job of president and vice president. In an allusion to Romney's bumbling summer trip overseas, Obama joked: "You might not be ready for diplomacy with Beijing if you can't visit the Olympics without insulting our closest ally.


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National College Application Week
National College Application Week is a national movement to help students recognize the need to apply early to various colleges. The earlier application date allows students greater financial/scholarship opportunities, more choices of colleges and more time to prepare for their college freshman year.
During College Application Week, the University of Alaska, working with several high schools and counselors around the state, will be encouraging high school seniors to apply to at least one college. Our intention is to try and have someone available at each site to answer questions from students, and to help them with filling out applications.

subset: commoncrawl


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MIAMI LAKES, Fla., Oct. 4, 2012 /PRNewswire/ -- Fuse Science, Inc. (OTCQB: DROP), (www.fusescience.com) an innovative consumer products company that possesses proprietary technologies set to redefine how consumers receive energy, medicines, vitamins and minerals, today announced that it has engaged New York-based investment banking firm Atlas Strategic Advisors (www.atlasadvisors.com) to explore strategic transactions involving Fuse's proprietary technology. Fuse Science will also be advised by Gaurav Kapoor, former Managing Partner & Principal at New England Consulting Group, where he worked for 15 years, leading landmark M&A and licensing transactions in the pharmaceutical and consumer package goods industries.
In our recent letters to shareholders, and subsequent teleconferences, we reiterated details regarding the Company's strategies, progress and value creation for shareholders. During these communications we discussed the three main growth engines for Fuse Science:
1) EnerJel™ - Our first growth engine, which we believe will enable us to build a profitable base business.
2) Our Drop Technology - Our second growth engine which is 100% incremental to the base business.
3) The science underlying our EnerJel™ and Drop Technology products – our third growth engine, designed to further build revenues through licensing in the pharmaceutical, OTC and nutraceutical, industries.
We anticipate the announcement of our science results in early October, which is a significant enabler of our third growth engine for the company. Today's announcement is in preparation for this event. The findings of the study will indicate if the advanced form of the Company's proprietary delivery technology has the ability to deliver various actives through the epidermis to the blood stream in a patchless roll-on application. The molecular structure of the test cells in the study ranged from small, water soluble and rigid molecules to large, greasy and flexible molecules. A few examples include Folic Acid and Estradiol on one end of the spectrum, to the cancer drug Paclitaxel, and large molecule Insulin on the other. The Company believes that success in many of these test cells will represent scientific first's and set the stage for significant advancement in the delivery of medicine and nutrition in humans and animals.
"We are extremely confident in the capabilities of Atlas Advisors and Gaurav Kapoor to help us aggressively advance the third growth engine for the company, said Brian Tuffin , Fuse Science, Chief Executive Officer. "It is our stated objective to extend the rights to our proprietary technology to the leading companies in each applicable business category. Today's announcement combines a team of experts in the pharmaceutical, OTC and nutraceutical industries, and our pending results will indicate how far-reaching our structured M&A and licensing process will be."
About Atlas Advisors
Specializing in mergers and acquisitions and corporate finance advisory, Atlas Strategic Advisors, LLC has closed more than $32 billion in transactions worldwide. The company has served as a strategic advisor to corporate clients, private equity firms and entrepreneurs. Atlas Advisors offers its clients first-rate advisory capability across Europe, North America, Latin America and Asia. For more information, visit www.atlasadvisors.com
About Gaurav Kapoor
Gaurav is the former Managing Partner & Principal at the New England Consulting Group, the premier marketing management consulting firm in the world. He is the first and only person to have been promoted to the Managing Partner & Principal position in the 30 year history of the New England Consulting Group. Gaurav has played a leading role in building NECG's presence in the healthcare and private equity industries from scratch, and has helped NECG become a leading consulting firm in both industries. In addition, he has consulted extensively for clients in the pharmaceutical, consumer packaged goods and financial services industries. Gaurav is known in the consulting industry for his relentless pursuit of "big ideas" for the client. His work has generated billions of dollars in new value for NECG clients through new products, M&A/licensing, and marketing optimization, etc. He is also considered a thought leader in business and has been published numerous times in leading trade journals. With an Engineering degree from the Indian Institute of Technology and an MBA from Carnegie Mellon University, Gaurav has a strong analytical and science based mindset and is an expert on advanced market research methodologies and algorithms for business applications.
About Fuse Science, Inc.:
Fuse Science, Inc. (OTCQB: DROP), is an innovative holdings company based in Miami Lakes, Florida. Fuse Science holds the rights to new, patent-pending technologies poised to redefine how consumers receive energy, medicines, vitamins and minerals. The company maintains the rights to sublingual and transdermal delivery systems for bioactive agents that can now, for the first time, effectively encapsulate and charge many varying molecules in order to produce complete product formulations which can bypass the gastrointestinal tract and enter the blood stream directly either through a topical gel roll-on or alternatively in a concentrated "DROP" form that is simply applied under the tongue. The Fuse Science technology is designed to accelerate conveyance of medicines or nutrients relative to traditional pills and liquids and can enhance how consumers receive these products. Information about Fuse Science is available online at www.fusescience.com and www.poweredbyfuse.com or by calling 305-503-FUSE (3873).
For more information:
To schedule an interview:
Fuse Science, Inc.
Gus DeQuesada
Investor Relations
Michelsen Advertising
Direct: (305) 503-3873, Ext. 2
Email: firstname.lastname@example.com
Safe Harbor Statement
Certain statements and information included in this release may constitute "forward-looking statements" as defined in the Federal Private Securities Litigation Reform Act of 1995. Such forward-looking statements involve known and unknown risks, uncertainties and other factors which may cause the actual results, performance or achievements of the company to be materially different from any future results, performance or achievements expressed or implied in such statements. Additional discussion of factors that could cause actual results to differ materially from management's projections, estimates and expectations is contained in the Company's SEC filings. The Company assumes no obligation to update any forward-looking statements as a result of new information, future events or developments, except as required by federal securities laws.
SOURCE Fuse Science, Inc.


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Chris Christie's million-dollar ad buy
New Jersey Gov. Chris Christie is hitting the airwaves Wednesday for the first time in his reelection bid with an ad buy north of $1 million, two media buying sources told POLITICO.
The buy is for more than $800,000 in the pricey New York market, and nearly $400,000 in the Philadelphia market, one of the sources said. The ad will run through May 12 on broadcast and cable.
Story Continued Below
( PHOTOS: Chris Christie's career)
Both markets, which are among the most costly in the nation, stretch into New Jersey.
Christie is facing Democrat Barbara Buono, a state senator who has struggled to gain traction against the popular Republican incumbent.
( Also on POLITICO: Christie's first ad touts bipartisanship)


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COLUMBUS – A two-out, two-run rally in the bottom of the ninth inning by Columbus State in Game 1 of a Peach Belt Conference doubleheader against Georgia Southwestern on Sunday afternoon lifted the 19th-ranked Cougars to a 2-1 victory at Ragsdale Field. CSU scored seven runs over the first two innings of Game 2 for a 7-2 win and series sweep of the Hurricanes.
GSW falls to 23-19 overall and 9-12 in the PBC. The Hurricanes have lost five of their last six conference games and must win two of three next weekend against 12th-ranked Francis Marion to qualify for the PBC Tournament. Columbus State improves to 29-14 overall and 13-8 in conference play. The Cougars are currently the West Division leaders and, with three PBC games remaining, can finish no worse than the West's second seed in the conference tourney.
In Game 1 on Sunday, GSW finally broke a scoreless game with a run in the eighth. The sequence started with a Stephen Gaylor one-out walk. Beau Parker followed with a chopper in front of the plate that he was able to beat out, putting runners on first and second. Michel Coffey then had the clutch hit singling through the left side to bring in Gaylor.
GSW brought in closer Gray Carden in the bottom of the ninth inning and overpowered the first two batters striking both out. Ahead 1-2 in the count, Carden hung a slider to Mitch Rider who hit a single to leftfield. Pinch-runner Aaron Jividen advanced to second base on a wild pitch then slid in safely to tie the ballgame at 1-1 after Eric Weiss singled through the right side. As the throw went in to home, Weiss took the extra base moving up to second. Scoop Pharr hit the walk-off single to left field plating Weiss.
GSW starting pitcher Jody Sellars was impressive on the mound working eight scoreless innings and limiting the Cougars to just three hits. Carden (3-2) suffered the loss throwing 2/3 of an inning and surrendering two runs on three hits. Beau Parker, Michel Coffey and Paschal Poston led the offensive attack for the Hurricanes each going 2-for-4.
CSU starter Tyler Carpenter allowed one run over 7 1/3 innings on six hits and three walks. Brian Satterfield picked up his second win of the series tossing the final 1 2/3 innings of the game as he improved to 3-0 this spring.
CSU had six different batters pick up a hit in the contest, none put together a mulit-hit performance.
In the series finale, Columbus State scored all seven runs in the first two innings and cruised to a 7-2 victory. The Cougars opened with four runs in the first inning and added three in the second.
GSW pushed both of its runs across in the fifth. Heath Lock was hit by a pitch to start off the inning. Gaylor followed with a walk. After the first out of the frame was recorded, Coffey singled to left field to load the bases. Andrew Archer hit a sacrifice fly and Jared Allen had an RBI single.
Parker and Allen paced GSW by picking up two hits apiece. The Hurricanes tallied nine hits in the game to match CSU. Zach Whitman (4-4) bounced back after a shaky start to work six innings allowing seven runs - four earned - on eight hits and three walks while striking out four. Hunter Thompson threw the final two innings picking up a pair of strike outs surrendering just one hit.
Weiss and Tyler Googe had two hits apiece for Columbus State. Brodie Leibrandt (6-2) allowed two runs in the complete-game effort while giving up nine hits and striking out five on the afternoon.
The Hurricanes return home for a 5 p.m. game with Albany State on Tuesday.


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Allyson Felix and the US 4x100 relay team made the best of a second chance, qualifying easily Thursday night in a solo re-run of the heat in which Felix got jostled and lost control of the baton.
Race officials upheld an American protest and the US made it around the track safely and quickly — their time of 41.77 seconds wound up best among the qualifiers.
These were hardly ideal conditions. The lead-off runner, Bartoletta, returned to the track a little more than 12 hours after taking gold in the long jump.
Felix has been battling a sore ankle for months, along with the emotions of not qualifying for the 200, then finishing a disappointing second in the 400.
Asked if she got hurt amid the jostling Thursday morning, Felix said: "No. Just upset."
Replays of the race show Brazil's third runner, Kauiza Venancio, start to pump her arms as she gets ready to receive the baton from Franciela Krasucki. Venacio's left arm made contact with Felix's right one and threw her off balance as she was attempting to pass to Gardner.
Felix let out a yelp as her flip missed its mark and the baton tumbled to the ground. She picked up the baton and told Gardner to finish the race a heads-up move that may not have really changed anything, per the rulebook, but removed any doubt about the U.S team's intention to finish the race. Anchor runner Morolake Akinosun finished but the Americans didn't post an official time listed as a "DQ," until officials let them back in.
"I remember them telling us, if there's an appeal, you have to make an effort," Felix said.
In less-jarring news, the U.S. men's team coasted through the preliminaries easily, winning their heat in 37.65 seconds. Jamaica's relay team also made it through, finishing second in their heat without Usain Bolt, who was resting up for the 200-meter final later in the evening.
It puts Jamaica, and Bolt, in position for a third straight title in the sprint relay.
"The only pressure is to make sure we get the stick'" around, said Asafa Powell, the former world-record holder who ran the third leg.
It's been more of a problem with the United States than the Jamaicans over the years.
The U.S. women dropped the baton in both the 2004 and 2008 Olympics to give away potential medals in an event that was virtually made for the team with the deepest pool of sprinters.
The U.S. men have either been disqualified or failed to get the baton around the track eight times at Olympics or world championships since 1995.
"First thing I did is told the young guys, 'We got this,'" veteran Tyson Gay said after running the men's third leg. "You've got to be positive. A lot of things happen out there."


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United Way of the Lowcountry's 2012 campaign cleared its first million this week as residents and businesses respond to local needs. The campaign is at 36 percent of its $2.8 million goal.
The United Way of the Lowcountry Board of Directors announced gifts and pledges have been received totaling $1,003,936, about 36 percent of the organization's 2012 Fall goal of $2.8 million.
Every $100 contribution to United Way of the Lowcountry provides a young man between the ages of 14 and 17 who has been referred by the S.C. Department of Juvenile Justice to AMIkids Beaufort with 34 hours of instruction to support academic achievement.
This year, AMIkids Beaufort added a welding program in partnership with TCL, through funding provided by the Stranahan Foundation. Now, students can work toward their GED and earn welding certificates to help them gain employment.
To learn more about United Way of the Lowcountry and its work to make the community a better place, call 843-982-3040 or visit www.uwlowcountry.org. A secure online payment system is available.


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Sheet music downloads have become the preferred method of acquiring classical music repertoire. Created by professional musicians, EveryNote.com presents classical sheet music download of over 20.000 popular and hard-to-find music scores over 1000 composers. A major Internet provider of classical sheet music files download online, EveryNote.com offers the largest and most complete digital sheet music download library on the Web in the world. Instantly download, view and print your favorite classical music score. Everynote.com currently offers thousands of classical music compositions for Piano, Violin, Cello, Flute, Clarinet, Classical Guitar, Voice, Chamber and Choral music.Many more instruments, composers, genres added every day! EveryNote.com has been featured in The New York Times, Globe and Mail, Musical America and many other publications.
Arrigo Boito
(1842 - 1918)
Arrigo Boito short biography
Arrigo Boito was a distinguished Italian composer and librettist. Boito was a librettist for Verdi's operas Simon Boccanegra, Otello and Falstaff. Boito also wrote the libretto for Ponchielli's opera La Gioconda. Boito's wrote both music and words for his only opera, Mefistofele, inspired by Goethe's Faust that had a huge success all over Europe. The arias from Mefistofele have become popular recital repertoire.
More Boito sheet music download on EveryNote.com
Boito Piano sheet music download on EveryNote.com
Boito Classical Guitar sheet music download on EveryNote.com
Boito Sacred Songs Arias Ensembles sheet music download on EveryNote.com
Web design by Web design SEO & Hosting Company - iGenii inc


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Editing note
Please note that we have had to block unregistered users from editing this wiki because of the amount of spam it was receiving. Anyone can still add content - including you! You just need to contact one of the Web managers and request an account.
For wiki editors
Consult the User's Guide for information on using the wiki software. You can also find useful information on the MediaWiki FAQ, the Wikipedia Editing Fundamentals Page and the MediaWiki Handbook For Editors.
- Wiki instructional material: includes webcasts of wiki howto demos.
Some useful edits to get started
The following tips were borrowed from ALA Midwinter 08 wiki.
- edit - To make changes to a page, click the edit tab at the top of the page. This will take you into the edit screen.
- format - Here are a few minor formatting tips.
- italicize - put the word(s) you want to italicize in between two single quotes -- not double quotes --
- bold - put the word(s) you want to make bold in between three single quotes
- headings - to make headings, you use the the equals sign on either side of the word(s) you want to turn into a heading. There also needs to be a space between the word and the equals sign on either side of the text.
- largest heading - example: = Main Heading =
- medium heading - example: == Subheading ==
- small heading - example: === Sub-subheading ===
- link - Please feel free to add hyperlinks and crosslinks to other wiki pages. Here is a quick and dirty guide, much more is available from Wikipedia
- linking to another wiki page
[[ALA Acronyms]] will get you ALA Acronyms. NOTE: This is how you create a new page as well. On an existing page, create an internal link with [[NEW PAGE TITLE]]. Save the page. Click on the NEW PAGE TITLE (the link will be red signifying a page without content) and you'll be taken to the edit box of the new page.
- linking to another wiki page using your own text
[[ALA Acronyms|List of ALA Acronyms]] will get you List of ALA Acronyms
- linking to another web page
[http://www.ala.org/midwinter] will get you [1]
- linking to another web page using your own text
[http://www.ala.org/midwinter/ ALA Midwinter] will get you ALA Midwinter Homepage
- linking to another wiki page
- list - If you are starting a list of tips, links, or comments, or are adding to a list, please start your addition with an asterisk (*), which shows up on the wiki like this
- Example.
- It's just a good way to set each distinct contribution off from the rest. Two asterisks will indent what you write as you can see on this line.
- look - The best way to learn how to format things on the wiki is to look at how people have formatted things on other pages. Just hit "edit" at the top of the page to see how people did what they did.
- annotate - You have the option of adding little notes to your edits in the Summary box beneath the editing page.
- discuss - Every page on the wiki has a discussion page that you can use for discussing an article. This is often more useful than making an edit, having someone else undo it, and back and forth. These pages can be for asking questions about the topic, or informal coverage of a topic.
Uploading a file
It's a 2 step process:
1) upload file. you should see the link "upload file" in the lower left of the navigation. Here's an example of an uploaded file:
2) copy the link to the uploaded file (i.e., http://wikis.ala.org/godort/images/7/79/Question_Guide.doc). Go to the page you want to show the file and use the following wiki syntax:
More information on uploading files on the media wiki help page
For wiki discussion contributors
- Every page has a "discussion" tab at the top. This page should be used for commenting on a page, discussing best practices for a particular project. It's common wiki etiquette to end any comment with 4 tildes
~~~~. This is wiki syntax which causes the wiki software to add your user name (with a link to the user name's talk page) and date/time stamp to your comment. It's quick, easy and extremely helpful. The output of the 4 tildes looks like this:
Jrjacobs 15:00, 17 July 2007 (CDT)
- Every user has a "talk" page that is similar to the discussion page. Use this page to leave messages for a particular user. Don't forget the tildes!!
For wiki admins
- To edit the left-hand navigation, go to MediaWiki:Sidebar. This page can only be edited by those with admin privileges. Edit thoughtfully :-)


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Celeste Wallpaper
Removable and damage free wallpaper is the answer to your household desires! Our wallpaper is a fun and easy way to make a statement in any room! For those who do not want to make a long-term commitment to a permanent design or for renters who cannot Simply remove with no damage! From bedroom walls to kitchen backsplashes, transform any space! Wallpapers are printed on an innovative, self-adhesive removable material, which allows them to be applied and peeled multiple times without losing stickability! Please read our FAQ page thoroughly before purchasing.
Panels ordered at separate times may not be perfectly seamless to each other.


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Welcome to the Piney Woods Wine Trail. We hope you enjoy your self-guided travels through this beautiful area of East Texas. From country stars to down home bars and from rustic farms to elegant charm, you can visit them all without ever leaving the trail.
Click on any of the wineries below to go to their websites.
Please make sure you check their website for current tasting room hours.


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I am using over 10 KML in Google Maps. When I increase the number of KMLs they load too late.
I use checkboxes to hide/show KML layers. With up to 5 KML layers, it worked fine. When I increase the size of the KMLs it's not working normally.
When I check "show", it shows but "hide" does not work ...
How can I solve this?


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The American Medical Association will do "whatever we can in our power" to help implement the 2010 health care law, the group's president said Tuesday.
In an interview taped for C-SPAN's Newsmakers, Ardis Dee Hoven, who became the AMA's 168th president last month, said the White House has not approached her or the AMA directly about a formal role, but "we have been in communication with many, many individuals in the administration about our role as physicians in this and what we can help them do, and what we can do to help our patients get the kind of information they need.
"We will continue to work with the administration and do whatever we can in our power to make this happen," said Hoven, an infectious diseases specialist from Lexington, Ky.
In the C-SPAN interview, which will air Sunday at 10 a.m. and again at 6 p.m., Hoven said that while there are shortages of physicians, nurses and other health professionals, a greater focus on team-based care will ensure that Americans who now have health insurance, as well as the millions who are expected to gain coverage through the law, will get the care they need.
"I think there will be enough doctors," she said. "We will have to practice in team-based care. We will have to be more efficient." She said it's hard to know now if people who currently have health insurance will have to wait longer to see a physician.
Hoven's top priorities are improving health outcomes for patients, including in the areas of cardiovascular disease and diabetes; accelerating change in medical education; and sustaining physician practices in an era of consolidation.
She said that the AMA is studying 30 medical practices across the country that vary in size and specialty but all have good health outcomes and high levels of patient and physician satisfaction. The project will determine "what are the key elements, what are the things that make those practices tick?" Hoven said. "How can we translate that information into work that would be good for doctors and practices right now?"
Hoven is also focused on repealing Medicare's payment system for doctors, called the sustainable growth rate, or the SGR. The House Energy and Commerce Committee recently released a revised SGR overhaul plan.
"We have seen demonstrated bipartisan support for repealing the SGR and replacing it with other models and transitioning to those models," she said. "There is good support for this. I am very enthusiastic about this."


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Scott Morgan necesitaba un nuevo diseño de logotipo y lanzó un concurso de diseño en 99designs.
Un ganador ha sido elegido entre 167 diseños de 56 diseñadores freelance.
Scott Morgan Marketing
I live in a beautiful small town in the mountains of British Columbia Canada. Good jobs can be hard to find in our remote small town but I've managed to find a nice little niche marketing our local (and world-class) golf courses. See greywolfgolf.com and columbiavalleygolftrail.com (currently re-designing this site).
I currently just mange the marketing activities of our golf courses but I don't want to limit myself to marketing golf courses. I'll eventually look to branch out into other sectors (when I get the time).
My main strength is creating and managing the overall marketing plan. I'm a big believer in sticking to what you're good at so I am constantly seeking out highly skilled sub-contractors to help me put the pieces of my projects together.
Other strengths are: managing the development of websites, email marketing, search engine and web marketing.
Smaller companies (1 - 50 employees) in need of someone to create and manage their marketing plan. Most of my future clients will most likely be local, but I'll be looking to branch out to customers via the web long term.
I'm looking for a simple, clean, unique, text based design. It can have a small graphical element to it.
I'd like it to be horizontal and roughly 2 1 /4 units wide by 1 unit high.
Please don't use any stock images or clip art.
Chances are the winning design will be blue.
I'll need aEPS and PNG files and a black and white version version.
Descubre cómo funciona un concurso de diseño u obtén más información sobre nuestros servicios de diseño de logo.


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True to the adage that "art is subjective," the fountain on the corner of Sixth Avenue and Main Street in downtown Hendersonville has invoked its share of debate. One of the most common disputes has focused on its price.
True to the adage that "art is subjective," the fountain on the corner of Sixth Avenue and Main Street in downtown Hendersonville has invoked its share of debate. One of the most common disputes has focused on its price.
Initial cost estimates for the "Mountain Memory" fountain by Arden artist Berry Bate were penciled in for close to $121,000 (including a 10 percent contingency) before the final concept of the piece was decided. Unforeseen costs brought the final price tag up to $183,284.
Guri Andermann, who is running for a seat on City Council, asked the board where the money to cover the difference came from, but left before the answer was given at the meeting Sept. 5. Councilman Jerry Smith said the overruns were covered by contingency funds and bonds already approved for the project.
"We were able to cover the additional cost by allocating money from the 2008 sidewalk bond project to cover some of the sidewalk installation on Main Street. This freed up money in the construction budget to cover the additional costs for the fountain," City Manager John Connet said Monday. "Also, it is worth noting that we received a $20,000 check from the Community Foundation (of Henderson County) as a contribution for the fountain construction in March."
Extra money was needed to pay for the pump, filtration and sanitation system and a sturdier cement base to counterbalance its top-heavy weight, according to City Engineer Brent Detwiler.
The $1.6 million contract for the third and final phase of streetscape improvements to the 500 through 700 blocks of Main Street was awarded to Trace & Company in December. Although close to $143,000 was earmarked for two gateway art projects in the phase, only one came to fruition and its amount did not include specific costs for the piece or the mechanics to operate it.
Once the artist's concept was refined for the fountain, Detwiler said all parties involved in the project's construction met in January to hammer out the details.
Medallion Pools of Arden was called in to install the mechanical infrastructure of the fountain at a cost of $66,275. Professional Engineer Mark Dorsey said their work also included the installation of a sanitation system with ozone technology, which uses free oxygen atoms to oxidize and destroy foreign particles.
The ozone generator is considered to be one of the cleanest, most eco-friendly ways to treat potable water, and Dorsey said the fountain downtown is unique to have the feature in its purification system. Medallion Pools also constructed an underground vault to store the fountain's mechanics in one safe, easy location.
Six lines currently feed the fountain with water that travels to at least two filters before it makes its way up and out through the mountain range, Detwiler pointed out with the reinforced vault doors open Tuesday.
Medallion Pools poured the structure of the fountain, originally anticipated to be cinder block, with solid concrete to accommodate the weight of the multiple 500-pound boulders used in its construction.
Final cost estimates, provided by the city, include an $86,230.59 bill for the artist (with a $343 savings in lighting for the final piece); $1,529 for additional plants and moss to hide open spaces between the rocks in the fountain; $66,275 for Medallion Pools, for its infrastructure; $24,098 for a brick veneer and seat wall surrounding the fountain and lighting; $2,990 for granite curbstone directional markers; and $2,162 for two additional granite markers with logos.
Granite curbstone directional markers were added by the artist to the project after council requested that the artist refine her initial concept to include features relevant to Hendersonville.
"We received the change order for the granite directional markers a couple weeks ago," Connet said. "The directional markers were not part of the original brick structure component bid with the project and were added as part of the approved fountain design in December 2012.
"The plants were installed over the weekend. They were added due to a field call by myself in order to help them hide areas between the boulders. We had previously discussed the granite markers with logos."
Granite logos and a plaque detailing the artist's vision behind the piece are the last remaining items to be installed.
Downtown Economic Development Director Lew Holloway read the description set for the plaque to council at its meeting Sept. 5:
"'Mountain Memory' is inspired by the prominent peaks and rivers that surround Hendersonville. The sculpture's peaks, detailed in copper, represent Mt. Pisgah, Pinnacle and Sugarloaf Mountains. The sculpture's rivers, depicted in stone and water, are the French Broad, the Green, and the Big Hungry. Highlighting these features brings attention to the natural environment that is the foundation of our community.
"The fountain is divided by the copper ridgeline in much the same way as our county – which contains a portion of the eastern continental divide – is divided by natural ridgelines. The steep and swift Big Hungry and Green Rivers flow off one side of the sculpture, representing their travel to the Atlantic, while the larger French Broad cascades down the front side of the fountain representing its journey to the Mississippi River. Ms. Bate was inspired by the role these natural features have played in shaping our community over time and designed and built 'Mountain Memory' to pay homage to them."
Reach Weaver at email@example.com or 828-694-7867.


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- Bernese Oberland
- Swiss Alps
Introducing Switzerland
Swiss Alps © Artur Staszewski
Switzerland Travel Guide
Boasting one of the highest qualities of life in the world, two mountain ranges perfectly suited to skiing and other winter sports, a central plateau of rolling hills and beautiful lakes dotted with spa resorts, and an interesting mix of cultural regions, Switzerland's fame as a top European holiday destination is extremely well deserved.
For good reason, the majority of visitors seek out a ski holiday in Switzerland. The country's southern Alpine region is home to the highest pistes in Europe, and with reliable snow conditions, staggeringly beautiful scenery and top-class resorts, Switzerland is a natural choice for a dream winter sport vacation. Leading Swiss ski resorts include Davos (ideal for beginners), Gstaad, St Moritz (boasting the best views of all the resorts), Zermatt, and Verbier (the most popular ski resort in Europe, featuring outstanding accommodation, dining and shopping).
There is, however, more to Switzerland than skiing alone. Summer-time tourists will be overwhelmed by the beauty of the Bernese Oberland region, a land of distant snow-capped peaks, pristine lakes, edelweiss-strewn meadows and iconic wooden chalets. The world-famous resort of Interlaken is the most popular destination here, offering luxury accommodation, excellent hiking opportunities and easy access to one of Switzerland's most popular tourist activities, the cog railway that leads up to the plateau of Jungfrau Mountain.
This is, of course, to say nothing of Switzerland's cosmopolitan cities of Zurich, Geneva and Bern - elegant urban enclaves where rich history combines with modern development, progressive ideals, and wonderful dining and shopping opportunities; nor of its wealth of unforgettable tourist sites, which include the famously photogenic Château de Chillon and the Barbier-Mueller Museum.
Best time to visit Switzerland
The weather in Switzerland makes it an ideal destination throughout the year, and visitors trying to determine the best time to visit Switzerland are encouraged to first decide what it is they wish to see and do while in the country. The ski season lasts from the end of November to early April; while summer (July/August) is the high tourist season. Go in spring if you wish to experience the best of the countryside, while in autumn you may be able to find cheaper flights and better accommodation deals. Read more on Switzerland's Climate and Weather.
What to see in Switzerland
-Picturesque Lake Geneva is a must-visit for travellers in Switzerland.
-The stunning 13th-century Château de Chillon is a medieval castle that looks stolen straight from a fairytale.
-The historic city of Bern is a charming place filled with cobbled streets, ornate fountains and spired cathedrals.
-See the Lion of Luzern, which Mark Twain called 'the most mournful and moving piece of stone in the world'. Read more about Switzerland Attractions.
What to do in Switzerland
-Go to the Swiss Alps and experience some of the best winter sport action to be found anywhere in the world.
-Visit Interlaken, the king of Switzerland's summer resorts, and bask in the glorious sunshine, lake views and edelweiss fields.
-Take a trip on the cog railway to Jungfrau - and be greeted by awe-inspiring glacial fields and a 'palace' filled with ice sculptures.
-Take in some culture at one of Switzerland's celebrated museums, including the Barbier-Mueller Museum in Geneva, and the Museum of Design in Zurich. Read more about Switzerland Activities.
Getting to Switzerland
Cheap flights to Switzerland are easy to find from a number of airports in the US and UK. Direct flights to Geneva or Zurich are plentiful, while visitors from the UK can also find cheap flights to Bern and Basel. Get more information on Switzerland Airports.
Dark Palace by Frank Moorhouse.
North Face (2008), On Her Majesty's Secret Service (1969), and Heidi's Song (1982).
Zurcher eintopf (a hot-pot dish famous in Zurich), rippli (pork ribs), fondue, rosti and sauerkraut; also try desserts like apfelküchlein (deep-fried apple cookies) and nusstorte (nut cake).
Rivella, a milk whey-based soft drink; and try some locally-produced Chasellas or Pinot Noir wine.
What to buy
Watches and clocks (Switzerland is the watch-making capital of the world), chocolate, cheese, cow bells, clothing embroidered with edelweiss flowers and - of course - Swiss army knives.
What to pack
If you're going for a ski holiday, it's probably best to take enough warm clothes along with you (as shopping for new ones could prove to be expensive); while if you're travelling in spring or summer, take a lightweight rain jacket along in your day-pack in case of light showers.
What's on in Switzerland
The Geneva Festival (August) is the highlight of Switzerland's summer event calendar, with musical performances, food fairs, parades and fireworks displays. The Montreux Jazz Festival (July) attracts a crowd of more than 200,000 every year, and is deservedly renowned as one the best jazz festivals in the world. Art Basel (June) is known as the 'Olympics of the art world', and features work from 300 leading galleries from around the world. More information on Switzerland Events.
Did you know?
-Switzerland has not been at war since 1515.
-Switzerland has the second-highest life expectancy in Europe (after Sweden).
-The Swiss flag is the only square-shaped flag flown at the United Nations.
A final word
A land of cosmopolitan cities that function with the precision of clockwork, and of extraordinarily beautiful natural surrounds, Switzerland is quite simply one of Europe's finest tourist destinations.
Become our Switzerland Travel Expert
We are looking for contributors for our Switzerland travel guide. If you are a local, a regular traveller to Switzerland or a travel professional with time to contribute and answer occasional forum questions, please contact us.


text:
Canastota girls basketball drops close game to Little Falls
CANASTOTA -- Canastota's girls basketball team had the lead with less than three minutes to play against state-ranked and unbeaten Little Falls on Friday. Somehow the Mounties rallied to win 47-38.
Amy Hart had seven of her 10 points at the end of the game to lead LF back.
Shea Foster led the Raiders (4-6) with 24 points.
"I can't ask for much more," Canastota coach Vinny Salamone said of his team's gallant effort against a team that went to the state semifinals last year. "We got blown out by 17 the first time we played this team."
Hannah Becker had 11 points to lead LF (9-0).
Canastota 2 13 16 7 - 38
Little Falls (9-0): Kelli Shepardson 6, Hannah Becker 11, Gen Schoff 14, Sarah Bruins 6, Amy Hart 10.
Canastota (4-6): Shea Foster 24, Danielle Carlone 6, Abby Laflair 2, Allyson Malbouf 2, Chelsea Dolloff 4.


text:
"A world without end is the recognition of how by your point of view, you create endings to realities and possibilities. If you start to create a greater sense of how you create by your choices, you start creating a world that has no end but only has a continuous expansion and possibility." --Gary Douglas
Still time to join us! Next call October 28!
Are you looking for a description?
Well, some of the special Access Consciousness® telecalls actually don't have a description. The title is all that is required to spark your knowing. You know if this class is for you, description or not. Next call October 30!
Yes or No?
A three part telecall: November 18, 19, 20!
When you choose pain instead of power you have to suffer.
When you avoid the pain, you avoid the power that goes with it.
Pain is just an energy of power you avoid because you've been taught to do so.
A three call series: December 1, 2, and 3.
Are you looking for a scheduled teleclass? The Class Calendar is where you find it! With the Class Calendar Find Any Class search function you can refine your search to also find specific topics, languages and facilitators.TELECLASS CALENDAR
Ta stran uporablja piškotke. Če nadaljujete brskanje po tej spletni strani, se strinjate z uporabo piškotkov. Odkrijte več.
NE sledimo vašemu IP-naslovu in ne uporabljamo analitike, pikslov ali piškotkov za ciljno oglaševanje. Če smo vam všeč, nas znova obiščite!


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Do It Smart: Seven Rules for Superior Information Technology Performance
Simon and Schuster, 1999. dec. 22. - 224 oldal
A decade ago, manufacturing companies had visions of paperless offices, automated plants, and virtual enterprises. But the euphoria quickly evaporated when these visions failed to materialize. Now, from in-depth interviews in a worldwide survey of seventy manufacturing firms, a research team from the prestigious consulting group McKinsey & Company concludes that, far from being a failure, information technology (IT) can be a vital strategic weapon in the manufacturing sector, just as it has proved to be in service industries.
In Do IT Smart, experts Rolf-Dieter Kempis and Jürgen Ringbeck along with the McKinsey team identify four cultures of IT users -- stars, big spenders, cautious spenders, and laggards -- based on how efficiently and effectively the users manage IT. The stars stand out because their strong command of IT means they are better able to manage core processes such as R&D, sales and service, and order processing, which in turn produces tangible payoffs in profitability, growth, and market share. From their study of star performers, the authors formulate seven rules for developing a superior IT organization. First, they argue, managers must make IT a top management issue and, second, a priority in product development. IT must be viewed as a strategic tool so that IT strategy can be aligned with business strategy. Clear objectives must be set, and core business processes redesigned. Warning that IT is reaching saturation in administrative applications, the authors describe how it is far more profitable to integrate IT into marketing, sales, and customer service. Finally, they describe how all these elements must be brought together into a lean, customer-oriented IT network.
McKinsey's breakthrough study shows that as organizations are increasingly overwhelmed with data, IT will become more of a dividing line between the winners and the losers. IT stars will make quantum leaps in effectiveness, while poor management of IT results in a cost explosion. Managers and information officers who want their business to keep and gain the competitive edge IT offers need this unprecedented insight into how to Do IT Smart.
Mit mondanak mások - Írjon ismertetőt
Nem találtunk ismertetőket a szokott helyeken.
Más kiadások - Összes megtekintése
Gyakori szavak és kifejezések
achieve administration after-sales service application systems benefits BEST PRACTICE companies surveyed Companies with successful company's complex core business processes corporate success costs data warehousing databases design for manufacturability development partners effectiveness efficiency engineering ensure Executive information system Exhibit external consultants focus functions groupware impact improve industry information system integrated standard software interface internal Internet intranet IT-based IT-supported know-how knowledge management less successful performers less successful product logistics management materials and logistics McKinsey & Company ment operational core processes optimization order processing outsourcing Percent of companies phase potential PPS system process performance product configurator product data management production planning project management proprietary software rapid prototyping requirements return on sales SAP R/3 scheduling selection simulation Source specific staff stars IT laggards strategy successful product developers suppliers systematic systems implementation targets tion top management users
Népszerű szakaszok
ix. oldal - Acknowledgments This book could not have been written without the assistance of many people.
8. oldal - IT stars achieve above-average and rising returns, and grow faster than their markets...


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Coming Out of the Dark
Coming Out of the Dark
"Coming Out of the Dark" is 24" W X 36" H X 1.5" D painted with artist grade acrylics on gallery wrapped canvas with sides painted black. It is wired and ready to hang. It will be coated with a gloss varnish to protect from dust.
The purchase of this original artwork does not transfer reproduction rights. All rights remain with the artist, Stephanie Estrin.
Please note that all monitors are different and this image may appear lighter or darker on your screen compared to the actual painting. Every effort was made to accurately depict it's likeness.
Free shipping within the United States.
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we grew for you 2
we grew for you 2
from 29.99
Superior quality fine art print on smooth matte paper, 100% plant based, acid-free with archival pigment inks for exceptional longevity. Mounting and framing available by request.
If you'd like a print that you don't see here, contact me!
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It's time for some link love! There have been a lot of great posts written over the last couple weeks, here are some of my favorites:
- Kurn has evaluated her own healing performance and shares it with everyone. Whether you're a raid/class/healing lead and want to evaluate your raiders or if you just want to take an honest look at your own performance, this post gives some excellent ideas of things to look for.
- FeralTree has written an excellent post on the current and future state of druid healing. It has some very keen observations of our current strengths and weakness and some great suggestions on how to streamline our talents.
- Anexxia looks at what it takes to be a great raid leader. There is some good advice to be found both in the post and comments.
- Vixsin writes about the history of the shaman class and the delicate balance between performance and utility.
- Analogue gives some ideas on how to make healing more fun. Remove healer aggro? Yes please.
- Derevka takes a look at cooldown coordination, with suggestions on how to track cooldowns and announce when they're being used.


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Joined: 17 Nov 2009
Posts: 155
Posted: Thu Oct 11, 2012 4:31 pm
Post subject: Holding on or not
So i´ve been browsing since my last post on a "good season" but can´t find anything with the search system on the forum. Maybe i´m doing something wrong don´t know.
Anyway, last sunday i was heading out and about to get over a wave Similar size as i posted in last thread, don´t know what size to call that, head high or bigger i guess. Well timing sucked and when about to get over the wave i went flying backwards and had a good washing. I hung on to my gear by the boom and getting the wave basically over the sail so under it I at least started but soon i was up and breathing again. Then aimed for the tip of the mast and faced that agains the coming waves and hung on to that while taking a few on the head. Then things got calmer and I waterstarted and got out again.
Well after this i,m thinking a bit. Obviously it´s best to hang on to kit if possible. But like my scenario when you basically get dropped backwards while heading out is it best to hang on or does that increase the kit of breaking, for example by driving the mast down to the bottom? Well i´m not sure if anyone gets what i´m trying to ask but do you guys have any scenarios where you would just drop kit and bail out?
Just to make things easy and not be reffering to a pic in another thread i´ll just post the pic from last sunday again in this thread so you guys know about the wave size i´m talking about.
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Joined: 03 Jul 2009
Posts: 4561
Location: East Bay
Posted: Thu Oct 11, 2012 4:42 pm
Post subject:
Solid 6' wave, just after it breaks, is tough to punch thru the whitewater, which is bouncing around higher than your head. Shoulder high wave, or 4', is easy.
You should have tried to avoid the situation. Chicken jibe on the wave before that set wave, use you timing and smarts to head out at the end of a set, not at the end of a lull.
As for holding on or not, if given that situation, you do what you need to do to get the mast pointed out to sea, then get to the tip of the mast ASAP and become the anchor just like you did.
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Joined: 17 Nov 2009
Posts: 155
Posted: Fri Oct 12, 2012 3:32 am
Post subject:
Thanks for the advice, very helpful.
I realize that this situation could have easily been avoided with better understanding of the waves and timing. I at least was the only one that day getting into trouble :/ but things went better after that during my sessions and timing was better, so I hope i´m slowly gaining experience.
This world of wavesailing is just so thrilling, fun and different from any other windsurfing sessions. Lots of new stuff to learn and I will without a doubt seek advice again from experienced riders like you.
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Joined: 21 Aug 2002
Posts: 3307
Posted: Fri Oct 12, 2012 4:17 am
Post subject:
count the battens that are under the peak. that seems to be the easiest way for me to measure wave sizes. in 1999, the NWS asked everyone to start to measure waves from the bottom of the trough to the next peak, oncoming. the surf culture has resisted this. guess the wave reporters don't want to be labelled ask kooks for being over enthusiastic.
i just call it like i see it. if folks can't get there in time to partake, there's nothing i can do about it. other than not report?
hold on to the back foot strap when conditions are truly gnarly. sometimes, when i know it's breaking deeper on the outside, i'll hold the tail of the boom and the back strap for a the ride to one of those in between zones....
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Joined: 04 May 2004
Posts: 2704
Posted: Fri Oct 12, 2012 9:12 am
Post subject:
I gave up on holding the tip if in the rinse cycle....i think it's pretty easy to break a mast that way even if you sink it/duck dive it......i do what jingbritsen does, and hold the rear strap and boom......but that carries some risk to you in terms of sissoring....
if you hold the rear strap, at least you know where the fin is!
Really big...sometimes just a hug to the boom.....really really big ride it and let her go just before impact.....
seems like having the sail neutral in the water best to avoid breakage, so grabbing near the boom head good....I seem to break shit so maybe not the best person to answer
....def always stay on the outside of the sail,board....don't take a fin up the butt, and never-ever (well almost never ever) let go if you are still standing vertical! The more you hang on, the more you will make over....Bailing out is a self-fulfilling move ....if you get knocked off, it will be at the lip, and then at least you can jump to the back of the wave
That pic looks like a fun day, and there is always a cost
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Joined: 03 Jul 2009
Posts: 4561
Location: East Bay
Posted: Fri Oct 12, 2012 1:17 pm
Post subject:
However you hold it, the key is to NEVER allow the sail to get tossed shoreward of the board. That is the mastbreaker.
I've held on in big Revelations, easy 15' surfer measurement. I've held on at Sunset when RickyGregg was out on his 12' yellow gun. It's never fun, you end up using your overlapped arms, face, legs, feet, and body to maintain the death grip, but don't let go, because as soon as you do, the next wave will flip the rig shorewards of the board, the following wave will drive the board towards the rig, the rig sinks, and instant broken mast.
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Joined: 25 Aug 2003
Posts: 226
Location: Corpus Christi, TX
Posted: Fri Oct 12, 2012 2:48 pm
Post subject:
I agree--hold on. Personally, at least with the type of wave we get here and the type of gear I ride, I'm much more comfortable holding the tip of the mast than any other location. Even on the biggest day I've ever ridden, which was mast-high, I'd go for the tip. I wear gloves, not for this reason, but as a bonus they make gripping easier, and my sail tip has a strap, so that adds to the traction.
I'll grab the back footstrap only as an emergency measure if that's the only thing I can get a handle on before the next wave hits. Holding the back strap, I've been tumbled hard enough that I get pushed onto the gear, and a powerful wave exerts more force on my gear than I can control, so there's definitely a chance that the fin and my face could meet. So this is just me, but I stay away from the fin til I'm ready to waterstart. Also I am not a fan of holding near the boom because I've had a lot of force build up that way too, levering my forearm harder than I'm comfortable with. Again, just my personal preference, but not worth breaking my arm over. Luckily we don't have coral or rocks here, but we do get a strong current at times. Losing grip on gear can result in swimming a ways. My longest swim has been 20 minutes. Luckily I've always caught the gear before anything reached the beach and got broken.
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Joined: 03 Jul 2009
Posts: 4561
Location: East Bay
Posted: Fri Oct 12, 2012 3:22 pm
Post subject:
Straps can be a good idea, but it's necessary to be able to dump the rig when it get's hairy. Mostly, bigger surf is longer period, and you get pushed in 100' with each wave, so maybe 3-5 deathlocks at the max.
A much worse situation is 5'-7' shorepound, where the water sucks back out into the impact zone, and the surf there is hollow, and sucking up stuff off the bottom. Couple that with relatively short period groundswells, and you could go thru the rise cycle repeatedly for over half an hour with your gear, and possibly in sub 55 degree waters.
A good deathgrip uses every part of your exterior body, as any less, you get to see your mast break, your sail tear, your fin get snapped on shore, and you get to repair the little dings all around the deck of your board..
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Joined: 19 Sep 2004
Posts: 256
Posted: Fri Oct 12, 2012 9:45 pm
Post subject:
No advice here... just props for getting out there in those conditions! It takes some real character to commit to going out in waves like that!
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Joined: 08 Sep 2010
Posts: 645
Posted: Fri Oct 12, 2012 10:40 pm
Post subject:
zirtaeb wrote:
A much worse situation is 5'-7' shorepound, where the water sucks back out into the impact zone, and the surf there is hollow, and sucking up stuff off the bottom. Couple that with relatively short period groundswells, and you could go thru the rise cycle repeatedly for over half an hour with your gear, and possibly in sub 55 degree waters.
A good deathgrip uses every part of your exterior body, as any less, you get to see your mast break, your sail tear, your fin get snapped on shore, and you get to repair the little dings all around the deck of your board..
Hey that sounds like my first trip to the oregon coast, right after I touched a fish with my foot...
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We would like to wish Greg Jennings and Tom Crabtree all the best on the newest journeys in their respective careers. (Well, we wish them the best when they are not playing the Packers). Greg and Tom are two classy guys who fully represented what it means to be Green Bay Packers. They were great to the fans and they were great on the field.
85 and 83, you will be missed...
...Dang...I'm gettin' all choked up....I'll just let Michael, Nate, Shawn, and Wanya take it from here.
Go Pack.


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Follow RFF News on your cell phone. Text follow rff to 40404 you will receive txt messages with RFF News
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hours of operation ..8 amfoot race to the clue box BQ's arrive 3rd and.......
The BQ's go WAY past the deoturnow heading back T/J at the detour first followed by the Bamas
I love Phil's smile when the BQs hugged him. Wonder what he was thinking?
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The one I photographed recently is in tiny Butter Cemetery. It is a sandstone tablet marker with a willow-and-urn motif.
Memory of
who died,
March 22nd 1831;
aged 23 years
and 10 months.
Weep not for me, my friends so dear;There is another marker for Samuel Noe in Marengo Cemetery—three miles away. The inscription on that marker, a photograph of which is posted on OhioGravestone.org, is a bit different than the Butter Cemetery marker, but not where it counts: name, date of death, and age at death.
I am not dead, but sleeping here;
My end you know, my grave you see;
Prepare yourselves, to follow me.
Son of
Died Mar. 22, 1831
Where is Samuel Noe buried? My theory is that he is buried in Butter Cemetery under the sandstone marker ("my grave you see") and that his name was inscribed later on a family marker in nearby Marengo Cemetery.
There is at least one other name on the Marengo Cemetery marker, but I cannot read it in the OhioGravestones.org photo. Can you? Looks like a trip to Marengo Cemetery is in my future.
Butter Cemetery, Morrow County, Ohio


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Hungry: Man From Atlanta Goes Off In Taco Bell For Giving His Food To The Wrong Customer!
Shot in ATL Taco. Submitted by Upenz
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This thread consists of only the story... PLEASE DO NOT HAVE DISCUSSIONS HERE! DISCUSSIONS ARE TO BE HELD IN THE DISCUSSIONS THREAD.
This thread consists of only the story... PLEASE DO NOT HAVE DISCUSSIONS HERE! DISCUSSIONS ARE TO BE HELD IN THE DISCUSSIONS THREAD.
Szema Fei groaned as he watched two kids on the street eat Candy On A Stick. His stomach moaned as hunger took over him. Szema Fei dashed after the two kids quickly. As he reached them he grabbed one stick with his left hand and the other with his right. He ran for it.posted by TommyH
But before he was able to make his escape several adults has already caught sight of his doings. They blocked his path...each of them had a disgusted look on their face. They started yelling at Fei with words that lowered Fei's ego until it couldn't be lowered anymore.
Soon more adults came and soon enough people were spitting on Fei and kicking him. Fei moaned with both fear and hunger. He started to weep silently at first then started to cry out loud. At the sound of the noise people started feeling guilty that they were beating a kid up so they instantly stopped and left the crowd.
A man who had just seen the scene play itself out, decided to go over to the boy. He had been to far away and the crowd obstructed his view so he couldn't really see what had happened earlier.Posted by DuGu Qiu Bai
He walked over to Szema very fast. As if he were going to attack something.
The man immediately put his hand over Szema Fei's shoulder and pulled part of his shirt open. "How did you get this tatoo?", "Who are you?", the man shouted while pointing to the now exposed demon tatoo on Szema's back.Posted by Single Whip
Szema was scared and tried to struggle free. Strangely, even though the man's palm was seemingly as light as a feather, Szema could not get out from under his grasp. The more he struggle, the heavier the man's hand become.
This man is none other than Wang Zong Yueh.
At that time, another person yelled out from the rooftop nearby, " Let him go, or else!."
posted by TommyH
At the cause of the distraction Szema Fei quickly shook the man's hand off and quickly joined the mass of people who were shopping on the street. Wang Zong Yueh turned his eyes from the man from the rooftop to where he thought Szema Fei still was...he gasped as he realized that Szema Fei escaped, he turned his head back towards the man atop the roof but spotted no one...
Wang Zong Yueh knew that he would not be able to find Szema in the middle of all this crowd. So he started walking absent-mindedly pondering what had just transpired. As he walked, his sight fell upon the back of someone walking ten feet ahead of him. "There is something oddly familiar about the way that person moves." he thought. "Although I could not recall what or why." "I'd better follow him from a distance."Posted by Single Whip
Wang Zong Yueh walked silently behind this figure. He continued to follow him until they reached the edge of town and entered the woods. Wang Zong Yueh then realized that something was wrong...posted by TommyH
The man turned around and looked at Wang Zong Yueh with an amusing look. "Yes. How are you Brother Zong Yueh."
"Big Brother?! Is that really you?" gasped Zong Yueh.
Wang Jian Yi laughed as he patted Zong Yueh. "Yes it's me. It's Jian Yi. I haven't seen you, my little brother, since you departed from Wudang four years ago. Why did you leave?"
Zong Yueh frowned. "I just didn't like Wudang. I don't like Taoism. I don't want to! Anyways...did Zhang WuJi continue to teach you martial arts?"
"Yeah. Let's not discuss this. Remember that kid with the Demon tattoo?"
"Yeah...," said Zong Yueh. "You were the one who distracted me?!"
"Yes. We have to investigate further upon this tattoo...," said Jian Yi.
"It looks like the tattoo of the legendary Demons & Dragons Sect...," mumbled Zong Yueh as he stared at the deep brown eyes of his brother.
posted by Single Whip
"It is so odd." Zong Yueh said to Jian Yi, " That tatoo is only given to leaders of the sect and his family. But that kid obviously had never learned any martial arts."
Szema Fei ran down an alley and panted for air. How does this guy know he had a tattoo? It must have been another hole in my shirt, thought Fei. Fei waited for another five minutes then walked out of the alley and blended back into the mass of people.posted by TommyH
His hunger continued to grow until, at last, he couldn't hold it anymore. He really did need something to eat. Fast too. He glanced around and noticed that there was a noodle stand nearby. He headed towards it. When he reached the stand he just watched people eat their noodle noisily. He licked his lips as he watch a man leave a tael/coin on the table and left.
Szema Fei ran forward and grabbed the bowl and immediately drank the remaining soup and sucked the little pieces of noodles. The stand owner thought Fei was about to steal the money to he quickly grabbed the tael/coin on the table and shooed Fei away...
"True, it seems very strange that we "happened" to bump into him." remarked Jian Yi as he stuided Zong Yueh.Posted by druid
"Beats me. " answered Zong Yueh.
"yes yes.. this does not brood well. But enough of this, have you been improving in your martial arts? Shall we have a friendly duel?" smiled Jian Yi as he put his sword down.
"haha. I've made some improvements in my Taiji Quan with the help of Elder Zhang Song Xi before i left Wudang. After you brother!" Replied Zong Yueh...
Li watched as the two men fought. The Taiji Quan made Li very curious. After watching the two maen exhange 50 strokes, Li was able to comprehend Taiji, the elementary concepts of it.Posted by DuGu Qiu Bai
Ban Meihua had only been passing by (running alon the rooftops of the homes) when she saw all that happened, the boy with a tatoo, and now she was watching the people fight. She's stayed to watch, but only for a short moment before going back to looking around at the shops. While passing by the noodle stand she saw that boy with the tatoo again, but knowing it was none of her business she just walked by without a word.Posted by Da Bao
"Friend! Why wont you come out and have a friendly duel with us? You have been observing us for sometime now." Voiced Wang Jian Yi.Posted by druid
"Huh? What? Someone was watching us this whole time?" Thought Zong Yueh.
Slowly, Li Kang emgere out of the bushes. Cuppling his hands together, he paid his greetings to the two.
"Li Kang pays his respects to the two swordsman. I hope you do not mind me watching your duel."
"Hahaha. Not at all friend. So how much have you comprehend? Your face seems too pale for a man of your age. Are you suffering from any illness?" Enquired Jian Yi, as Zong Yueh studied the stranger.
"Unfortunately, i suffer from tuberculosis. I am lookin for a doctor who can cure me."posted by DuGu Qiu Bai
"Have you gone seen Shui Dou Yi? I am sure he can cure you."Posted by yittz
"I have heard of his name and I have been seeking him on and off for the last few years, while being treated by other healers. But alas to no, I have not had the fortune of meeting him. He seemed to have disappeared from jianghu." *sigh...
"Hrm...would you brothers join me if i were to go search for him?"posted by DuGu Qiu Bai
Two men walked down the street, with weapons in hand. They sat down at a stand table and quickly ordered two bowls of noodles. The older men smiled at the younger men and shouted happily, "It's the Heroes' Conference! I heard the old Leader of Wulin, Hero Cheung, is retiring. Haha! It's most likely there's going to be a Martial Arts Tournament to selecting the new Leader."posted by TommyH
The younger man looked at his elder then said, "Well it's not going to be me nor you."
Szema Fei happens to be standing nearby. Upon hearing this news he quickly thought of a way to steal some food.
Posted by strife_au
A young man arrived at the stand table, as he entered he sees Szema Fei acting sneaky, so he quickly followed him. He gently taps Szema Fei on the shoulders, he could see that he was starving. "Hey young brother what are doing?" said the young man. "Thats none of your business" replied Szema Fei. The young man thought to himself for a moment and smiled "would you like to join me in having a bowl of hot & spciy beef noodle young brother?" Suddenly Szema Fei had a huge smile on his face "YES if you are so kind sir."
The two seated on the table, The young man asked "whats your name young brother?" "Szema Fei, just a poor beggar. whats your name you look like a martial artist with your sword, are you quite famous in wulin?" replied Szema Fei
'Well my name is Shue yun zen, you can just call me Shue Yun if you want. he he I'm not famous in wulin, just a wanderer exploring the magnificent wonders of Jian Hu" said Shue Yun with a smile.
At this point however, Li Kang suddenly vomited blood and fell to the ground.Posted by druid
Seeing their "newly-found" friend react in this manner, both swordsman rushed to Li Kang and quickly put him into a sitting position.
Li Kang however was very much conscious and was already generating his own Qi to supress the spread of the disease.
"Such high internal strength! who is this man?" both swordsman thought as they checked his pulse.
Wang Jian Yi then began to put both his palms onto the back of Li Kang, and his 9Yang Zhen Qi began to flow into his body. Zong Yueh was busy checking he pulse of Li Kang to see if his condition improves.
As the 9Yang zhen qi flowed into the body of Li Kang, Li kang felt this very soft and gentle qi flow into his body, spreading all over. This qi not only help strengthened his own, it greatly suppressed the effects of the disease. Only after a short moment later, Li Kang opened his eyes and..
"Thank you for your help brothers! I Li Kang am deeply indebted to you!" with that Li Kang proceed to kneel.
"Please! We do not deserve this! I'm afraid I cannot completely heal you with my internal strength. Come, you need to rest at an inn. After that my brother and i will proceed to the Hero's Conference where there is a high chance that the Shui Dou Yi might be present. For now let us find an inn for you to rest." replied Wang Jian Yi as he helped Li Kang up. Together with a smiling Zong Yueh, all three men walked towards an inn where Shue yun zen and Szema Fei were....
posted by Single Whip
As they came near the inn, the two brothers immediately spotted Szema Fei. They exchanged quick glances at each other and Zong Yueh whispered, " Don't worry, I won't act so rashly this time. Let's just observe the boy from a distance first."
The three men then went inside to the inn across the street from where Szema and his companion were, and sat at an empty table where Zong Yueh could not be seen by Szema.
Jian Yi then said to the inkeeper, "Sir, can we have a couple of rooms and some of your dishes?"


text:
In need of a mini pick me up? Come hither for 5 days of mini pick me up giveaways. Join in!
Benefit Porefessional is a rather nifty invention, a product that you apply under or over make up to create a poreless finish!
It's a weird product, I mean its blue but it does leave quite a smooth finish!
They say:
Apply this silky, lightweight balm for translucent pore coverage and smoother-than-smooth skin. Pores…now you see 'em, now you don't! Complements all skin tones.This can be used under or over makeup.
Wanna win?
Method 1.
Answer the following question:
Where is your favourite hiding place?
It used to be the wardrobe. Now? The toilets. Any toilets.
Method 2.
Follow me on Twitter and retweet (RT) the following message:
"RT @cosmetic_candy: Follow & RT a Benefit Porefessional Primer. Info: http://tinyurl.com/5vqvjtp"
*Note: if you change the tweet, it will not count as an entry.
Good Luck!
Winners will be contacted shortly after the competition ends (in 10 days). If the winner doesn't reply within 2 days the prize will go to the next person.
Depending on weight your prize will be sent recorded or standard post. I always get a receipt. I do not have endless samples to send out to you if your prize is 'lost' but I would suggest that you check with your depot to locate it's whereabouts. Repeat: I will not send a prize out to you 5 times, do not take the piss.
Prizes are usually sent out within 5 days of a competition end but please allow up to 28 days. I do actually have a job and a life beyond going to the post office. Sort of.
Love you all lots, enter and have fun!


text:
Research Findings
Five groups of patients enrolled in the Why WAIT program were studied, for a total of 62 participants (22 men and 40 women). They had an average age of 56.1+1.4 years (mean±SE), diabetes duration of 7.2+0.8 years, and a BMI of 38.3+0.69 kg/m2 Over 12 weeks, participants lost an average of 23.5+1.2 lbs or 9.8+0.4% of their initial body weight (p<0.001) and 3.7+0.3 inches from their waist circumference (p<0.001). HbA1c decreased from 7.26+0.17% to 6.37+0.11% (p<0.001). Total cholesterol decreased by 12.2+1.8% (p<0.001), triglyceride by 21.8+3.8% (p<0.01) and LDL by 11.4+3.0 % (p<0.001). C-reactive protein (CRP) decreased from 6.0+0.85 to 4.2+0.65 mg/L (p<0.01). CRP reduction correlated with the percentage of weight and fat loss (p<0.05).
Participants were able to maintain the achieved weight loss for another six months after the program with the help of the support sessions.
Page last updated: October 15, 2019


text:
This high security 16 gauge steel console features Tuffys patented pushbutton latch system. For safety and convenience while operating the vehicle, the lid also latches closed without having to be locked. It has a spacious compartment for mounting a CD changer, storing tools, electronic equipment, cellular phones, and other valuables. Rubber floor mat is included,
what are the dimensions on this unit? the 032-01
Asked by RD from Woodland on
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Answered by email@example.com from Woodland on
There are two pictures here for this product. One console is longer than the other. Which one is for sale?
Asked by from on
Hello, we are very sorry for the confusion. We are removing the incorrect image so that this won't happen again. But in the meantime if you click this link this is the product you will be receiving. http://www.4wd.com/aux_incl/images.ashx?i=032-01.jpg&w=300&h=300&partNo=TFY&jeep-parts=true Sorry again for the confusion, if you have any other questions please let us know. Thanks.
Answered by Jamey P. from on
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text:
The book by former media adviser to Prime Minister Manmohan Singh today continued to make waves with Finance Minister P Chidambaram rejecting suggestions that it was Congress President Sonia Gandhi who was running UPA-II.
The author, Sanjaya Baru, himself maintained that "it was not a secret" that Gandhi held the reins of government, a point that was backed by former Cabinet Secretary T S Subramaniam.
"I don't," Chidambaram said when asked whether he would agree with the claim that Sonia held control of the governments.
Answering a question whether in the past 10 years never was there an occasion when the PM had to go to No 10, Janpath for clearance, he said never in the past 10 years the prime minister has told him that he had to "go back and ask someone" to take decisions"We are in a party democracy. There are decisions and decisions. Some decisions can be taken within the government. Some have to be taken only after consultation with the party. This is political party government.
"Some decisions were taken after consultations within the UPA. Is not the CPI(M) consulted on a decision to taken by its government. Do not state political parties give their inputs to their governments," he asked.
"If it is a political decision which requires political consultation, well, I myself have taken it to the Core Group," Chidambaram said.
Asked about Baru's claim PM's Principal Secretary Pulok Chatterjee, who was inducted into the PMO at Gandhi's behest, held daily meetings with her to take instructions on important files to be cleared by the PM, Baru said, "that's not a secret.
He said,"It is just one para, three sentences. I have written a lot of positive things about the PM. In UPA-I he was an accidental PM. He did not contest to become PM. But in 2009 the victory was Manmohan Singh's victory.
"For me it was personally tragic. He (PM) was becoming a but of jokes, especially in the social media, like when he went to a dentist he was told 'now you can open your mouth'."
However, he added that despite what was happening politically the two leaders were deferential to each other.
Asked about the timing of the book, the veteran journalist timing was not decided by him but by the publisher.
Queried about the PMO's attack on him that he had misused privileged access for writing fiction for commercial gain, Baru said, "I am amused."
He said he has written a lot of positive things about the PM which were supportive of him. "There is criticism. But there is a lot of facts about what the PM did, which are positive".
Reacting to the furore over the contents of the book, former Cabinet Secretary T S Subramaniam said there was nothing new or that was not known. "I can only say that the real power was not with the executive but with the political side," he added.


text:
For race use only. Not admitted in the area of the German StVZO!
So, you want to replace your original cylinder? It was destroyed on the last ride-out or is becoming weak through age? Well, look no further! You can have a good quality 1:1 pattern replacement cylinder at a decent pric wich is also completely road-legal. What more could you ask for? We stock these RMS replacement cylinders in OEM quality. We als have the original PIAGGIO kits available. Not all of these kits automatically include a cylinder head.
Iron cast / 2 stroke or 4 stroke/ 39-40mm bore/ - 8500 rpm's.
Identical dimensions, performance and appearance to the original, fully road legal, existing cylinder head can be retained, peripheral items (carb., exhaust, etc.) do not require modification or adjustment.
SIP-TIP! Renew the roller weights and the spark plug. A gasket set is included. Before installation, remove any rough edges from the bore of the cylinder.
German Magazine Scooter & Sport Jan/Feb 2003: "...won't increase performance, RMS has european wide homologation and is a real alternative to often expensive original parts."
OEM Numbers (for the purpose of comparison)
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text:
Combination Chemotherapy in Treating Patients With Unresectable Locally Advanced or Metastatic Stomach Cancer
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT00006081
Recruitment Status : Completed
First Posted : July 25, 2003
Last Update Posted : July 30, 2012
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
PURPOSE: Phase II trial to study the effectiveness of combining bryostatin 1 and paclitaxel in treating patients who have unresectable locally advanced or metastatic stomach cancer.
|Condition or disease
|Esophageal Cancer Gastric Cancer
|Drug: Bryostatin-1 Drug: Paclitaxel (Taxol)
|Phase 2
- Determine the response rate in patients with unresectable locally advanced or metastatic adenocarcinoma of the stomach or gastroesophageal junction treated with bryostatin 1 and paclitaxel.
- Determine the qualitative and quantitative toxicity and reversibility of toxicity of this regimen in these patients.
OUTLINE: Patients receive paclitaxel IV over 1 hour on days 1, 8, and 15 and bryostatin 1 IV over 1 hour on days 2, 9, and 16. Treatment continues every 4 weeks for at least 2 courses in the absence of disease progression or unacceptable toxicity. Patients with a complete response (CR) receive up to 4 more courses after achieving CR.
Patients are followed until death.
PROJECTED ACCRUAL: A total of 18-35 patients will be accrued for this study.
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|37 participants
|Intervention Model:
|Single Group Assignment
|None (Open Label)
|Primary Purpose:
|Official Title:
|A Phase II Study of Bryostatin-1 (NSC 339555) Plus Paclitaxel in Patients With Metastatic or Unresectable Locally Advanced Adenocarcinoma of the Stomach or Gastroesophageal Junction
|Study Start Date :
|June 2000
|Actual Primary Completion Date :
|September 2005
|Actual Study Completion Date :
|September 2005
|Experimental: Bryostatin-1 + Taxol
Drug: Bryostatin-1
40 mcg/m2 one-hour infusion 24 hours after each dose of paclitaxel (i.e., day 2, 9, 16).
Drug: Paclitaxel (Taxol)
80 mg/m^2 one-hour infusion weekly x 3 every 4 weeks
Other Name: Taxol
- Number of Patients with Response after 2 Cycles of Treatment [ Time Frame: 8 Weeks ]
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years and older (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Patients with histologic proof of adenocarcinoma of the stomach or gastroesophageal junction will be eligible.
- Patients must have either metastatic or unresectable local-regional cancer
- Patients must have measurable disease, defined as lesions that can be accurately measured in at least one dimension (longest diameter to be recorded) as greater than or equal to 20 mm with conventional techniques or as greater than or equal to 10 mm with spiral CT scan.
- Patients may not have received prior chemotherapy or immunotherapy regimen except in the adjuvant therapy that ended at least 6 months prior to registration on this study.
- Prior limited radiation therapy is permitted. Prior radiotherapy must not have included major bone marrow containing areas (pelvis, lumbar spine), or contained the single evaluable lesion in the radiation field. A recovery period of at least 4 weeks after completion of radiotherapy is required prior to enrollment. Patients receiving chemotherapy used as radiosensitizer will not be eligible except if chemoradiotherapy was administered in the adjuvant setting (see 4.4).
- Patients must have a life expectancy of at least 12 weeks.
- Patients must have a performance status of less than or equal to 2 (Zubrod scale) or greater than or equal to 60% (Karnofsky scale) (see appendix B).
- Patients must give written informed consent.
- Acceptable liver, renal, and marrow function
- Patients must be be at least 18 years old.
- Patients must have recovered from recent surgery. One week must have elapsed from the time of a minor surgery and 3 weeks from major surgery.
- This clinical trial is so designed that no person shall on the grounds of race, color, gender or national origin be excluded from participation in or be denied the benefits, or be otherwise subjected to discrimination through or under this study.
Exclusion Criteria:
- Patients may receive no other concurrent chemotherapy, immunotherapy, or radiotherapy.
- Patients with brain metastases are not eligible.
- Patients with NYHA Class III or IV heart disease are not eligible (see Appendix F) as well as those patients with history of angina, myocardial infarction, or congestive heart failure within six months.
- Pregnant or lactating women because paclitaxel and bryostatin-1, like most other anticancer agents, may be harmful to the developing fetus and nursing newborn or infant. All women of child-bearing potential must have a negative pregnancy test prior to entry into the study. All patients of child-bearing potential must be advised of the importance of avoiding pregnancy and using appropriate methods of contraception while participating in this investigational trial.
- Patients with serious intercurrent infections, or nonmalignant medical illnesses that are uncontrolled or whose control may be jeopardized by the complications of this therapy, are ineligible.
- Patients with psychiatric disorders rendering them incapable of complying wiht the requirements of the protocol are ineligible.
- Patients with serum calcium greater > 12 mg/dl or symptomatic hypercalcemia under treatment are ineligible.
- Patients with only bone metastases.
- Patients with any concurrent active malignancy other than non-melanoma skin cancers or carcinoma-in-situ of the cervix. Patients with previous malignancies but without evidence for greater than or equal to 5 years will be allowed to enter the trial.
- Patients wit bleeding diathesis or those requiring anticoagulation will be excluded.
- Patients with only non-measurable disease, defined as all other lesions, including small lesions (longest diameter < 20 mm with conventional techniques or < 10 mm with spiral CT scan) and truly non-measurable lesions.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00006081
|United States, Texas
|CCOP - M.D. Anderson Research Base
|Houston, Texas, United States, 77030-4009
|University of Texas - MD Anderson Cancer Center
|Houston, Texas, United States, 77030-4009
|Study Chair:
|Jaffer A. Ajani, MD
|M.D. Anderson Cancer Center
Additional Information:
|Responsible Party:
|M.D. Anderson Cancer Center
|ClinicalTrials.gov Identifier:
|NCT00006081 History of Changes
|Other Study ID Numbers:
U01CA070172 ( U.S. NIH Grant/Contract )
P30CA016672 ( U.S. NIH Grant/Contract )
MDA-ID-99203 ( Other Identifier: UT MD Anderson Cancer Center )
CDR0000068069 ( Registry Identifier: NCI PDQ )
|First Posted:
|July 25, 2003 Key Record Dates
|Last Update Posted:
|July 30, 2012
|Last Verified:
|July 2012
stage III gastric cancer
stage IV gastric cancer
stage III esophageal cancer
stage IV esophageal cancer
adenocarcinoma of the stomach
adenocarcinoma of the esophagus
Stomach Neoplasms
Esophageal Neoplasms
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Gastrointestinal Neoplasms
Digestive System Neoplasms
Neoplasms by Site
Digestive System Diseases
Gastrointestinal Diseases
Stomach Diseases
Head and Neck Neoplasms
Esophageal Diseases
Albumin-Bound Paclitaxel
Bryostatin 1
Antineoplastic Agents, Phytogenic
Antineoplastic Agents
Tubulin Modulators
Antimitotic Agents
Mitosis Modulators
Molecular Mechanisms of Pharmacological Action
Adjuvants, Immunologic
Immunologic Factors
Physiological Effects of Drugs


text:
PANCREATIC DISEASE COHORT A Registry and Biospecimen Bank to Better Understand Pancreatic Disease
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT01102556
Recruitment Status : Recruiting
First Posted : April 13, 2010
Last Update Posted : February 25, 2019
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
|Condition or disease
|Pancreatic Cancer
Pancreatic cancer is the fourth leading cause of cancer death in both men and women in the United States. According to the American Cancer Society facts and figures, approximately 43,920 people in the United Sates will be diagnosed with pancreatic cancer in 2012, and it is expected that 37,390 will die from the disease. The dismal prognosis of the disease is clearly depicted by the fact that its incidence approximates its mortality. Pancreatic cancer has a 95% case fatality rate. The etiology of pancreatic cancer remains elusive and our knowledge of its precursors and natural history is preliminary and incomplete. The uniform fatality of the disease merits priority attention in the search for its cause.
Due to the rapid progression of the disease, early detection and prevention provides the best hope for reducing morbidity and mortality. However, the few screening tests available for early detection and/or prevention of neoplastic lesions are poorly studied and prohibitively impractical in the general population. Further, few pancreatic cancer risk factors are well established or widely accepted. Advanced age, family history, cigarette smoking, diabetes, and some dietary risk factors are established or suspected risk factors.
Due to the high volume of individuals seen at the pancreas center, we plan on enrolling 500+ individuals per year who have either been diagnosed with pancreatic disease or are at high risk for developing pancreatic cancer. All participants enrolled during a clinic/non clinic visit at Columbia University Medical Center (CUMC) will undergo a baseline visit and up to 3 subsequent visits. Additionally, based on the different conditions of pancreatic disease that we are enrolling, not all subjects will participate in all aspects of the program. For example, only individuals with cancer or pre-neoplastic lesions will have tissue collected and banked.
|Study Type :
|Observational [Patient Registry]
|Estimated Enrollment :
|1000 participants
|Observational Model:
|Time Perspective:
|Target Follow-Up Duration:
|1 Year
|Official Title:
|PREDICT: Pancreatic Disease Cohort. A Registry and Biospecimen Bank To Better Understand Pancreatic Disease.
|Study Start Date :
|July 2004
|Estimated Primary Completion Date :
|December 2030
|Estimated Study Completion Date :
|December 2030
Surgery Patients/High-risk Patients
Patients who have undergone surgery for pancreatic cancer or pre-neoplastic lesions of the pancreas will be accrued to the study. In addition, patients who are determined to be at high-risk for pancreatic cancer (with a significant family history) will also be recruited for study enrollment.
- Creation of a registry and blood/tissue bank [ Time Frame: 1 year ]The primary aims of this project are to create a registry, and blood and tissue bank for individuals at risk for pancreatic cancer.
- Improvement in the diagnosis, prevention, detection, and treatment of pancreatic cancer. [ Time Frame: 10 years ]The long-term goals of the study are to advance the knowledge of the etiology and epidemiology of pancreatic cancer. The epidemiological data will be correlated with the biological information and will allow for future investigative studies of pancreatic cancer etiology and tumor biology. It is anticipated and hypothesized that the knowledge derived will lead to improvements in the diagnosis, prevention, detection, and treatment of pancreatic cancer.
Biospecimen Retention: Samples With DNA
- Peripheral Blood Specimens: Three tubes of blood will be collected from each study participant.
- Archived Fixed Tissue Samples: Tissue blocks from surgery performed at CUMC or elsewhere, will be requested after obtaining consent for study participation.
- Fresh Tissue Collection: At the time of surgery for any tumor resection, tumor tissue and adjacent normal tissue will be requested from the Pathology Department. At the time of endoscopy, aspirated fluid or biopsied tissue will be requested. No additional tissue will be resected beyond that required for surgical or endoscopic management. In no circumstance will tissue be obtained solely for the purpose of the study.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years to 85 Years (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
|Sampling Method:
|Non-Probability Sample
Inclusion Criteria:
- Individuals who have been diagnosed with pancreatic cancer or suspicion of pancreatic cancer, a pre-neoplastic lesion in the pancreas who are 18 years or older
- Individuals identified to be high risk for developing pancreatic cancer who are 18 years or older based on the following criteria:
- The modified clinical Bethesda criteria for hereditary nonpolyposis colorectal cancer (HNPCC), which are as follows: individuals with 2 HNPCC-associated cancers (colon, endometrial, small bowel, hepatobiliary, pancreatic, genitourinary, or gastric), including synchronous or metachronous lesions; individuals with colon cancer and a first degree relative with an HNPCC-associated tumor and/or colonic adenoma (1 cancer diagnosed at age <45 years and the adenoma diagnosed at age <40 years); individuals with colon or endometrial cancer diagnosed at <50 years; individuals with right-sided colon cancer having an undifferentiated pattern (solid/cribiform) or signet cell histopathology diagnosed at <45 years; or individuals with adenomas diagnosed at <40 years.
- Those with a personal or family history of other pancreatic cancer associated syndromes including: Peutz-Jeghers syndrome, familial pancreatic cancer syndrome, familial breast cancer syndrome associated with BReast CAncer genes 1 or 2 (BRCA-2 or BRCA-1), hereditary pancreatitis, familial atypical multiple mole melanoma, and others.
- Patients in a family with a genetically determined cancer predisposition syndrome.
- Patients with a personal history of a gastrointestinal malignancy at age <45 years.
- Individuals at high-risk based on personal or family history, but not related to a known pancreatic cancer syndrome include the following: those with a personal history of pancreatic cancer, or a pre-neoplastic pancreatic lesion; those with a family history of two or more individuals with cancer, at least one of which is reported to be a gastrointestinal malignancy; a history of early onset (<50 years) gastrointestinal cancer in the individual or a family member; a history of multiple primary cancers, at least one of which is a gastrointestinal primary, or a family member of an individual meeting this criterion.
Exclusion Criteria:
- Inability to obtain informed consent for study enrollment.
- Under the age of 18 years old.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01102556
|Contact: Vilma Rosario
|Contact: Kimone Crossely
|United States, New York
|Columbia University Medical Center
|New York, New York, United States, 10032
|Contact: Vilma Rosario 212-305-6033 email@example.com
|Contact: Vilma Rosario email@example.com
|Principal Investigator: Jeanine Genkinger, PhD
|Principal Investigator:
|Jeanine Genkinger, PhD
|Columbia University
Additional Information:
|Responsible Party:
|Jeanine Genkinger, Assistant Professor of Epidemiology, Columbia University
|ClinicalTrials.gov Identifier:
|NCT01102556 History of Changes
|Other Study ID Numbers:
|First Posted:
|April 13, 2010 Key Record Dates
|Last Update Posted:
|February 25, 2019
|Last Verified:
|February 2019
|Individual Participant Data (IPD) Sharing Statement:
|Plan to Share IPD:
Pancreatic Cancer
Pre-Neoplastic Lesions
Pancreatic Cancer Surgery
High-Risk for Pancreatic Cancer
Tissue and Blood Bank for Pancreatic Cancer
Pancreatic Cancer Questionnaire
Pancreatic Neoplasms
Pancreatic Diseases
Digestive System Neoplasms
Neoplasms by Site
Endocrine Gland Neoplasms
Digestive System Diseases
Endocrine System Diseases