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Please read description carefully.
Do not base your order on the picture presented.
Description of the Whitehall Manufacturing E Series Extremity Whirlpool 15 Gallon
The Extremity line of whirlpools delivers the most versatile, economical, and ecological hydrotherapy setup possible. Their compact design saves space and the low-gallon capacity reduces water usage without sacrificing proper treatment. Each unit provides comfortable and effective treatment of precise areas of the body, such as the foot, ankle and lower leg as well as upper extremities like the elbow, forearm and hand. This option provides a standard stationary unit.
Medex SKU: WHT-E-15-S


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As one of the world's smallest and lightest headphones, the luxurious Klipsch X11i is our finest achievement in headphones to date.
Inside each museum-grade package lives a pair of superior audiophile headphones with tangle-free cords, a three-button remote for control over music and calls, and patented oval ear tips in multiples sizes to ensure maximum noise isolation and comfort.
Meaning manner, tune, measure, rhythm. Mode is how something is accomplished and in the case of the new Klipsch Mode M40 headphones, it's beautifully mastered. In every sense of the word. High-grade leather ear cups surround your listening experience with comfort. State-of-the-art active noise canceling (ANC) for up to 45 hours on a single battery or use without battery as a stereo headphone. With or without batteries, the show will go on the entire plane ride, the entire commute or the entire album collection.
With the Klipsch X7i, a new pinnacle in style, comfort and sound quality has been reached. These are the headphones you've been waiting for.
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Anyone can use the headphones that came with the phone. You've already paid those dues. Throw away your toys. It's time for real audio. It's time for the Klipsch X4i. Made with the finest materials, engineered for pure performance and designed to be the best looking, best sounding headphones on Earth.
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Bring your iTunes playlist to life with the legendary sound of the Image S4i headphones. Designed for audiophiles' favorite Apple products, the S4i comes with a three-button control and mic, allowing you to control the concert and your phone calls.
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An extra-large, 3-button remote lets you precisely control iPhone calls and music whether you're wearing bulky gloves or are simply on the go. And while the headphones' exterior is built tough, these in-ear headphones have patented oval ear tips to keep you comfortable. Rock the Klipsch Image S4i Rugged earbuds in yellow, orange, blue or red.
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Funnily enough, the blog management site has morphed into speaking only Spanish since I was last here. I'm not sure why this is so. My two years of Spanish language tuition at university has served me well. Carmen would be proud of me! I am down with the lingo - "nuovo post" indeed.
I turned 34 on Monday. I feel every bit of a thirty-something at the moment because I have a terrible virus. It started as a cold, moved to laryngitis and finally diarrhea (sp?). The joys of it all. To top it all off, after having some relative success with the sticker chart and car reward system, Nugget is having a particularly bad sleeping week (i.e. he is not sleeping, day or night), so I am tired and over it all really. It is nice to grow older though - I no longer feel the need to be accountable for all of the crazy stuff that I did when I was in my late teens and early twenties. It was all long enough ago to be the past and I can laugh about stuff (oh the angst of it all).
We went to Wiseman's Ferry to celebrate my birthday with some friends at the weekend. We had a lovely time, although with 9 young children it was a bit overwhelming at times. Nugget's poor sleep peaked at about 10.30pm on Saturday night when the Geege went downstairs to check on him and found him riding the ride-on lawn mower! Very scary. The adults had a game of Cranium and a wonderful meal and it was lots of fun being around big people again!
So the update on the post baby body - I have lost 4kgs in the last month. All of a sudden the weight is starting to come off (along with my hair!). To be fair, I have tried to cut out the enormous amount of chocolate that I was main-lining! We are off to a wedding at Port Douglas (Far North Queensland - check out the location at http://www.seatempleportdouglas.com.au/ ) in early June, so I decided to get my act together and try to get rid of some of the extra kilos before I have to wear a swimsuit again. Fear of "bearing all" seems to have been a good motivator for me! I shopped for a new outfit the other day too (first time in the stores for some time) - I found something that looks good even with me being bigger. Win-win.
I took a leaf out of Robyn's (from Mother's Group) book and decided to pick up some junk off the side of the road awaiting council pick-up. We were all out walking (now that I am on the weight-loss trail I do this walking business quite regularly again) and I spotted a cute little trike. It was like one I had as a child, and to be honest it was from that vintage I think. Metal. Plastic seat. Little bucket on the back to carry things in. I decided it would be a good idea to add this to the collection of bikes that Nugget has, so we picked it up and took it home. The Geege was reluctant because it was quite dirty. I convinced him that I would clean it up before Nugget had a ride and it would be all good. Of course, once Nugget caught sight of it he wanted to ride it straight away. We let him after he had a massive tantrum. Several days later, when Geege was cleaning it up (oops), he found a nest of red-back spiders! Three adults and millions of babies. It was unbelievable! I couldn't get over how lucky we had been that Nugget hadn't been bitten on one of his trial runs. I couldn't believe just how many spiders could live in such a small space. Very scary stuff. We still have the trike (sans the spiders now), but I don't think I will be a regular trash collector. We live and we learn...
Geege and I have been venturing out without the children of late. It has been wonderful. We went to my friend Luke's first gig (Ange is singing back-ups). It was at the Factory in Enmore and was such fun! Luke was fab and his sister's band (New Buffalo) is really great too. G and I had a wonderful time out with our friends. It was like life before the kids came along. Always nice to get a taste of the old life, just to remember how things were. We have also been out to a movie (Gold Class) for my birthday in the last few days (we saw "Zodiac"), so two outings without the boys. We really don't know ourselves. We do have one problem - Doo Dah won't take a bottle. At all. I have expressed 4 times now, but he refuses and gets himself into such a stressed out state. My poor sister-on-law has been having a awful time babysitting for us (you can imagine it can't you? Nugget getting in and out of bed all the time and Doo Dah screaming down the house wanting his breastfeed!) - I am surprised she has volunteered twice! We owe her big time!!!
I have been corresponding with my friend Susi in Germany. She "googled" me and got in touch. It is always so nice to be liked isn't it. She is a really great person, and was such a life-saver to me when I was in Germany. Anyway, it some recent email discussion she told me about a German word that I fell in love with. I love it the way German's have a word for everything. Wahlverwandtschaften is an awesome concept. It is the word for the group of friends who are not family but are like a family to you. We don't have a word for this in English, but I certainly have a Wahlverwandtschaft! Direct translation would be elected/chosen relationship, which really doesn't do the concept justice. If it weren't such a hard word to say I think it would be adopted into English - the way ueber has. This is the sort of thing I love about learning other languages. They fill in the gaps of life.
So my other news is that I am looking into a German speaking pre-school (Kindergarten) for the boys. I would really like them to have the option of learning another language (see above for an example of why), and figure that German would be a good one because I can at least help them at home too. I have all the information on the German International School which is in the area, the Geege has given his approval (even though the logistics will be difficult with both of us working) and now I just have to put in the enrollment forms. It is very exciting that they can have these opportunities, as we were never afforded them growing up in a small country town. I'm sure they will both be completely overwhelmed for the first few months, but children learn languages so easily and they will too.
Anyway, hopefully I will be back in the best of health in the next couple of days so I can return to my normal life. The Geege's Big Sis will be down from Tweed Heads this weekend, so it will be nice to see her. G is also off to the Buck's weekend for the wedding I referred to earlier. I don't expect him to be much help with the kids! The Hen's weekend is next week, so it will be pay back. I really need Doo Dah to take a bottle so I can go out for more than 3 hours!


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News » Crime
Watch: Stickers Sporting Anti-Gay Hate Pop Up Around Massachusetts City
Massachusetts may have been the cradle of marriage equality liberty in the early 2000s when that state's supreme court struck down barriers preventing committed same-sex couples from solemnizing their unions, but that doesn't mean there aren't homophobes lurking in the woodwork there, just as anywhere else.
Local news sources reported that stickers sporting anti-gay hate messages appeared around the downtown area of Attleboro, a city of about 44,000 people located 39 miles south of Boston.
CBS affiliate and Boston news channel WBZ reported on "disturbing messages of hate" that were "plastered all over that city" by a person or persons unknown. The report said that the stickers bore "anti-gay and racist slurs," and noted that "police are removing them as quickly as they can, but they really want to know whop's leaving them."
The WBZ report showed one of the stickers, which hade been affixed to "an electrical box and a light pole over the weekend," and said that their hateful messages made "many residents uncomfortable."
"The message threatened violence against the LGBTQ community," the report said.
The accompanying image showed one of the stickers before it was scraped off, with the slur blurred out; the visible text read, "touch me... and ill [sic] kill you"
One resident — a man whose son is gay — spoke out against the stickers, saying "You never know how far [it's] gonna go. I think you should take it seriously."
NBC affiliate Channel 10 also covered the story, with the mayor of Attleboro, Paul Heroux, telling the station, "This is not characteristic of Attleboro at all."
A tweet from the news station's reporter Ashley Cullinane showed a photo of one of the stickers. In this instance, too, the slur was blurred out.
Attleboro mayor @PaulHeroux says this homophobic, threatening sign has no place in his city - or anywhere. Tonight at 11 on @NBC10, you'll see this wasn't the only sticker posted in downtown pic.twitter.com/flBPEOIxSN— Ashley Cullinane (@NBC10_Ashley) December 5, 2018
The stickers were posted mere weeks after a caller phoned two Boston gay bars and threatened violence against their clientele. As previously reported at EDGE, the calls came about 24 hours apart, with the first being received by the manager of dbar in Dorchester on Friday night, Nov. 9 — just two days after a gunman terrorized a country music bar in California and killed a dozen people, including a security guard. The caller threatened to "shoot the place up," according to the establishment's owner.
The second call was placed to the Alley Bar in Boston on the following night, Saturday, Nov. 10. Police were able to trace the call back to a landline in the nearby Massachusetts town of Peabody. However, although the calls targeted Boston businesses and were made from within the state, they were reportedly the work of a teenager from New Hampshire. The male suspect was not named due to his status as a minor, but the police issued a statement saying that he had already been wanted in New Hampshire for "threats with public alarm and civil rights violations."
In much the same way as Boston city officials and police condemned those calls, Attleboro mayor Paul Heroux left no room for doubt that the threatening stickers were unacceptable to the city, declaring Attleboro to be "a very diverse community."
Added Mayor Heroux, "It's disappointing someone would do this because it doesn't reflect who we are or our values."
Police have launched an investigation, reports said, and any suspects who are caught could face vandalism charges — though not hate crimes charges, since the threats were not directed at any specific individuals.
Watch the WBZ report below.


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Calosens necesitaba un nuevo diseño de logotipo y lanzó un concurso de diseño en 99designs.
Un ganador ha sido elegido entre 54 diseños de 21 diseñadores freelance.
We are about to start a company with a new analytical device that is able to measure/sense heat flow in a nanoWatt scale. This is useful for a number of applications such as Diagnostics (bacterial infections, cancer), LifeScience, Cosmetics, Food... Usually it is used by scientists in the lab.
Our first application will be in the in vitro diagnostics market. Our device will be used in hospitals (by md's) to analyse blood probes of patients with bacterial infections (Meningitis, Sepsis) very fast in order to identify the right antbiotic medication and the accurate dose. Today still 30% of the patients die, because the existing methods are not fast and sensitive enough.
Medical Doctors, Scientists in the lab, PM's of big diagnostic companies (roche diagnostics, abbot diagnostics, qiagen)
- The logo should communicate technical competence, trust and quality.
- It should work worldwide.
- We would like to have it straight and reduced.
- Red or orange (or both) would be nice. The name could be black/grey.
- We want to use it on the website, letters, devices etc. so it should be flexible and versatile.
- It shouldn't have to many colors so it does not generate high printing costs.
- Some catchwords: heat, flow, sensing, measure, high-tech, nano, analyze
The files we will require are:
Print file format - .ai (CMYK)
Web file format - .jpg and layered .psd (RGB)
Please do not use any stock images or clip art in the logo and do not make it web 2.0 like.
Descubre cómo funciona un concurso de diseño u obtén más información sobre nuestros servicios de diseño de logo.


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Like living dangerously? Evidently one Washington man does.
If texting, eating and driving a truck all at once didn't seem dangerous enough, try what he allegedly did — texting, eating and driving a stolen truck.
Jeromy Kirkendall, 32, of Kennewick, Wash., allegedly lost control of the stolen truck he was driving, careened through a few lawns and logs and then crashed into a house Wednesday, the Tri-City Herald reported.
The reason, according to what he later told police: He had been distracted by the text message he was reading and the croissant he was eating.
Kirkendall fled the scene on foot after his car slammed into the home, but cops reportedly caught up with him later.
The woman who owned the house, Kathye Kilgore, told local NBC station KNDO that she was relieved she was inside and not in her front yard when he allegedly crashed into it.
"We heard this kind of thud," she said. "The house shook, and I'm going, 'That doesn't sound like somebody just dropping something.'"
KNDO reported that the crash caused about $6,000 in damage to the house.
Kirkendall, meanwhile, was booked into the Benton County Jail on suspicion of possessing stolen property.


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Info2024 necesitaba un nuevo diseño de logotipo y lanzó un concurso de diseño en 99designs.
Un ganador ha sido elegido entre 76 diseños de 33 diseñadores freelance.
eCortex is a research and development company dedicated to the idea that the most important advances in artificial intelligence will come from a deep understanding of the mechanisms in the human brain. We perform basic and applied research for defense and intelligence agencies in programs where the challenges are broad enough to defy narrow algorithmic solutions. Ultimately, we aim to develop commercial products for robotics and analysis of image, video, and other data.
The company was founded in 2006. It is the exclusive commercial licensee of the Emergent neural network simulator and IDE, along with models of the human visual system originally developed at the University of Colorado, Boulder.
We work with businesses, government contractors, partners and other research firms.
The logo should consist of a lower-case 'e' that is STYLIZED as a BRAIN, followed by the word "Cortex" in a complementary font. Both the 'e' and the BRAIN should be VERY EASY to perceive. It should have a futuristic feel, and some BLUE color should be included.
We are also building a new website that has a modern and clean look.
Descubre cómo funciona un concurso de diseño u obtén más información sobre nuestros servicios de diseño de logo.


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Make America Great Again
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I'm pretty sure this is actually the most important election in my lifetime.
Forum's pretty slow today. Allow me to speed things up with a super-wide view of the current political landscape.
You can thank me later.
I never like the idea of saying "this is the most important election of my lifetime" because it feels to hyperbolic. The only time I actually felt that way was during 2004 in the middle of the Bush presidency, but the Bush presidency gave way to the Obama administration, which is starting to unwind a bunch of the things I considered the Bush administration to have screwed up (the wars, the recession, the Bush tax cuts for the wealthy, Medicare's financial unsustainability). So it's pretty clear I overreacted in 2004. If only I had been a ChiefsPlanet poster then so you all could mock me for it.
All the other elections just seemed to be very important, because you can do a lot of things in 4 years when you've got the White House on your side.
The reason I think this election is so important, however, is because I don't think this election is about the next four years. I think the next decade of policy rests on this election's shoulders.
Obama was and is a game changer, politically. He represents the nation's fresh breath of anti-neoconservativism that the nation felt it needed in 2008 after Bush. Obama is unabashedly liberal, but incredibly charismatic and likeable (hardcore conservatives don't feel this way, but I assure you the polling has always suggested that everybody else does). The moment we elected him to was huge, as well, putting him right behind the 8 ball with the wars and the economy, a situation which clearly set him up for an extremely difficult four years.
If he is able to win reelection, it's possible that this country could face a true electoral realignment of Reagan proportions (or maybe even greater) within the next decade, the realignment that Rove so desperately wanted for Bush in 2004 but failed to achieve. I'm talking about a realignment that fundamentally changes the way the vast majority of the population views these two political parties.
I've written about this a lot on this forum, but I predict that no matter who wins the election in 2012, unemployment will drop like a rock in 2014 as the job openings/job applicant mismatches start to vanish and the pool of applicants adapt to all the job openings. Again, this is despite Obama or Romney being President.
But assume it is Obama. Then you're talking about, at the conclusion of 2016, a presidency that would have presided over a gradual but successful recovery from the worst recession in our and our parents' lifetimes, withdrawals from both wars in the Middle East, the killing of OBL, the passing and now implementation of full healthcare reform, and at least three SCOTUS judges... Even without Republican cooperation in Obama's second term, all these things would happen, with the only significant question mark being the unemployment situation, which I do believe will recover like gangbusters in a couple years.
If all these things happen, the contrast of the past two decades will be unbelievably stark in 2016: you can do it the Democratic way, like the charistmatic and successful Obama and Clinton admistrations did, and preside over successful economies and sane foreign policy, or you can do it the Republican way, like... George W. Bush.
Combine that with the demographic changes this country will be going over the next decade (Texas could genuinely become a swing state by 2020, for starters), and I believe we could be facing a realignment.
I think this would be especially likely if Hillary were to run in 2016. Barring a complete shitfit, she couldn't lose, running on the records of Obama and Clinton, who would both extensively campaign for her, giving her a 3-to-1 advantage over whomever the Republicans trot out. Thinking of what she could accomplish in the wakes of what these two Presidents have laid for her in terms of policy foundations, is mind boggling.
The Republican Party, in the face of this, would absolutely have to evolve from their current exclusivity, their current regressive tax policies, and embrace something more inclusive, more moderate, and less reactionary. More conservative, less reactionary regressive. And then you'd finally have the post-Boomer conversation about the true value of liberalism and conservativism that this nation has lost since the Vietnam war embedded the Boomer population in a decades-long culture war. This development would change the entire dynamic, and provide those weird things like "hope" and "change" that we've ridiculed for five years.
On the other hand, what if the Republicans win? Romney/Ryan '12.
Most of Obama's accomplishments would obviously be trashed. Healthcare reform would either be outright repealed, or simply not enforced and de-fanged until it could no longer accomplish much of anything. The Democratic goal of bringing back the Clinton tax rates for the wealthy would be a thing of the past; in fact, Romney and Ryan would move the offensive forward, attempting to bring their tax rates down even lower. The landmark regulations for the financial industry passed under Obama would almost certainly be neutered to the point of irrelevancy, in particular Consumer Protection.
But even more than his policies, the idea of what Obama represented would be defeated. The idea of providing more for the less fortunate, for collectivism and the social safety net, would suffer irreperable harm as Romney and Ryan get to benefit from an employment boom in 2014, something they will understandably take credit for and the public will understandably reward them for, embedding in the public psyche the idea that regressive policies somehow accounted for all of this, and cementing trickle-down economics as vindicated once and for all.
And while Ryan seems very green now, assuming Romney wins reelection, Ryan would be a powerful candidate under this philosophy in 2020 running against whomever the Democrats could put up. By then, barring any huge screwups or scandals by the Romney administration, the conversation between conservativism and liberalism would almost certainly vanish, and instead be between conservativism and libertarian regressivism.
You're talking about two radically different futures for the next decade-plus, one with generational realignment possibilities in my opinion.
All of it sparked from one election.
That's why I think this could be the most important election in our lifetimes.
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Typical Pat.
Good stuff.
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Some agreement that this election could have an effect on the Republican party that could reverberate for a decade at least.
How a Romney Loss Would Impact the GOP
Look for a sharp right turn away from the party establishment and its chosen candidate.
By Reid Wilson
September 27, 2012 | 6:00 a.m.
Today, the media and their pollsters are to blame for Mitt Romney's political troubles, according to Romney's fans. But if Romney does lose this year, blame will quickly shift to the Republican presidential nominee himself, his shortcomings, and his ability to articulate a conservative vision for the country. And the fallout from a Romney loss has the potential to reverberate through the Republican Party for a decade.
Had you told any Democratic political strategist a year ago that the unemployment rate in September 2012 would stand at 8.1 percent, he or she would have thrown up their hands in despair. President Obama, conventional wisdom held, would be headed to certain defeat.
But six weeks from Election Day, the picture is very different. Obama's approval ratings are on the rise, positive economic news hints at a recovery in the housing market and a slightly brighter jobs picture, and state-by-state polling shows Obama ahead of Republican nominee Mitt Romney in virtually every battleground state by significant margins. Even the dreaded enthusiasm gap, which showed Republican voters more likely to head to the polls than Democrats this year, is fading as more Democrats tune in.
Conservative pundits have blamed a complicit media; even pollsters are suspect. Every poll's sample composition is scrutinized for the slightest perceived irregularity. But if Romney does lose, Republicans will be forced to contemplate how their candidate blew the best opportunity to defeat an incumbent president since 1980. And while anger focuses elsewhere now, the blame will surely shift to Romney himself, and his backers within the WashingtonWashingtonPopulation (2010): 6,724,540Registered Voters: 0.00% R, 0.00% D, 0.00% I Governor: Gov. Christine Gregoire (D)Senators: Sen. Patty Murray (D), Sen. Maria Cantwell (D) Read Full Almanac Profile » Republican establishment, if he comes up short.
One can imagine the thought process: Romney, the moderate MassachusettsMassachusettsPopulation (2010): 6,547,629Registered Voters: 11.30% R, 36.50% D, 52.20% I Governor: Gov. Deval Patrick (D)Senators: Sen. John Kerry (D), Sen. Brown (R) Read Full Almanac Profile » flip-flopper, was insufficiently clear in articulating the views of the conservative movement and allowed his own shortcomings to distract from the cause, both of beating Obama and of advancing the agenda.
The blame game has already begun in some quarters. "There are a lot of elitist Republicans who have spent several years telling us Mitt Romney was the only electable Republican," conservative blogger Erick Erickson wrote on Tuesday. "They conspired to shut out others, tear down others, and prop up Romney with the electability argument. He is now not winning against the second coming of Jimmy Carter. They know there will be many conservatives, should Mitt Romney lose, who will not be satisfied until every bridge is burned with these jerks, hopefully with the elitist jerks tied to the bridge as it burns."
The schism within the Republican Party began during George W. Bush's administration ("They think the conservative movement will give them a pass just as the movement did with No Child Left Behind, Medicare Part D, Harriet Miers, TARP, etc.," Erickson added, ticking off Bush's greatest hits). The tea party movement, with its antispending message, stood in contrast with Bush's big-government conservatism, a virtual rebuke of party leadership, which the activist class believed had lost its way. If Romney loses, that rage at the establishment — Erickson's "elites" — will only grow.
The anger within the activist class has already caused political casualties, from UtahUtahPopulation (2010): 2,763,885Registered Voters: 0.00% R, 0.00% D, 0.00% I Governor: Gov. Gary Herbert (R)Senators: Sen. Orrin Hatch (R), Sen. Mike Lee (R) Read Full Almanac Profile »'s Bob Bennett to IndianaIndianaPopulation (2010): 6,483,802Registered Voters: 0.00% R, 0.00% D, 0.00% I Governor: Gov. Mitchell Daniels (R)Senators: Sen. Richard Lugar (R), Sen. Dan Coats (R) Read Full Almanac Profile »'s Richard Lugar sen. Richard Lugar Republican Indiana Read Full Almanac Profile ». It has also forced incumbent Republicans to change their tune, in hopes of avoiding the same fate. Senate Minority Leader Mitch McConnell sen. Mitch McConnell Republican Kentucky Read Full Almanac Profile », the picture of the Republican establishment, has hired Rep. Ron Paul's campaign manager — one of the party's best field operatives, to be sure, but one who brings tea party credibility to a candidate clearly worried about his right flank in the meantime. Aides to Sen. Lamar Alexander sen. Lamar Alexander Republican Tennessee Read Full Almanac Profile » have polled TennesseeTennesseePopulation (2010): 6,346,105Registered Voters: 0.00% R, 0.00% D, 0.00% I Governor: Gov. Bill Haslam (R)Senators: Sen. Lamar Alexander (R), Sen. Bob Corker (R) Read Full Almanac Profile »'s Republican voters several times, and they are notably relieved every time Alexander scores high approval ratings there. In the House, the most conservative wing of the Republican conference has gone from occupying the fringes with little influence to dominating the party's agenda.
If Republicans do lurch to the right, history suggests they will be vindicated in the near-term. The mid-term election under a second-term president is typically disastrous for the incumbent party as the six-year itch takes effect. Even if Republicans can't win back the Senate this year, their chances against the Democrats swept in by the Obama wave in 2008 will be strong.
By 2016, Republicans searching for a presidential nominee may incorporate two lessons from the previous two election cycles into their decision: 2012 will hint that moderates unable to articulate the most conservative vision can't win nationally, and 2014 will show conservatives can win. That would seem to buoy any of the more conservative candidates who might run for president — and Rick Santorum has already shown up in IowaIowaPopulation (2010): 3,046,355Registered Voters: 31.20% R, 33.40% D, 35.40% I Governor: Gov. Terry Branstad (R)Senators: Sen. Chuck Grassley (R), Sen. Thomas Harkin (D) Read Full Almanac Profile » twice since dropping out of the presidential race to campaign for other Republican causes.
The reinvention of the Republican Party that has been underway since the end of Bush's term is far from complete. Romney's loss would make the violence of the internal struggle all the more dramatic; it would steal influence from those arguing for a middle path, and hand influence to the conservative factions already on the ascent.
We ain't seen nothing yet.
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Thanks much for sharing.
We must reject the idea that every time a law's broken, society is guilty rather than the lawbreaker. It is time to restore the American precept that each individual is accountable for his actions. President R. Reagan
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This is not the year of Luigi. That's a marketing ploy. It's really the year of the sea shanty, and its triumphant return into the wider public (well, gaming at least) consciousness. Originally conceived as a means of passing the time while sailors engaged in back-breaking labour on a ship, 2013 saw them take centre stage in Ubisoft's Assassin's Creed IV, where they promptly steal the show.
They are, without a doubt, the best thing about that game.
Why? Because they're real history. Sort of. Let me explain.
Because of the way they're taught the subject, people tend to associate history only with immediate visual items, or catalogued information. The dates of battles, Kings of England, the clothes people wore, etc.
But that's just scraping the surface of our past. So much of the human experience never finds its way into a text book. How things smelled, how they felt, how they tasted, how things sounded.
So when we think of pirates, we think of ships, we think of hats, and we think of yyaarrgghh. We don't think of the more mundane parts of life, like singing while doing a hard day's work.
Without that sort of stuff, we're getting an entirely incomplete picture of how life used to be.
Assassin's Creed IV, on the other hand, thrusts sea shanties into the very heart of the game. They're a cult favourite, a singalong treat to pass the time on long voyages, a collectible to be earned through feats of athleticism in the game's towns.
Most games would be content to simply let you sail between islands. Maybe play some piece of music. But such is Assassin's Creed IV's devotion to really having you live through a time period that you're given the full experience.
Or, at least, you're getting a fuller experience of the myth. See, sea shanties weren't very common during the age of piracy in the Caribbean. In fact, there's little record songs were sung at all during that time on the decks of European ships. Most sea shanties you recognise, including the famous "Drunken Sailor", were actually first sung decades, sometimes even centuries later.
Perhaps the weirdest example of this discrepancy is the game's worst shanty, the maddening "Johnny Boker". This wasn't a pirate song at all. It actually dates from the 20th century, and has roots in African-American minstrel shows and folk songs. Indeed, a line from the actual shanty - obviously omitted from the game — is "O Jonny Boker, help dat n****r do, do Johnny Booker do".
This should be something to criticise Ubisoft for. After all, it's not history at all! It's pandering to a stereotype at best, and at worst, lying!
But given the context of Assassin's Creed IV, I can't help but feel there's a touch of appropriateness to it all. After all, outside of the Animus you're playing somebody who's not trying to catalogue history, you're trying to make entertainment out of it. You're always being told by your superiors, oh, we'll just cut that, or edit that, or change this to make it more exciting.
Just like Ubisoft have done here. I mean, sure, in reality pirates never sung sea shanties. They just chanted on the decks of their ships. Boring. But just like the staff at Abstergo Entertainment, Ubisoft's primary job isn't to educate you. It's to entertain you. And if they have to flesh out the experience of being a Caribbean pirate by borrowing another era's work songs, and playing to a stereotype, then the entertainment is better for it.
You may be living a lie of a life - a lot closer to that of a 19th century sailor than a pirate - but at least you're living a fuller lie.
Just remember that the next time you have to write an essay on pirate songs, OK?
Anyway, inaccurate or not, the songs are still awesome, performed with gusto and adding a ton to the atmosphere of the game's sailing sections. So here are the best of them! (With thanks to Kosappi Uni for the videos!)
That Lowlands harmony... it gets me every time. Even in a YouTube video. If this is playing on a calm night, and you're sailing with the moonlight at your back, well...if you're not covered in goosebumps, there's something wrong with you. Seek help immediately.
This shanty, British in origin, actually dates from around the 1860s, and is about a sailor's lady friend visiting him in his dreams.
It's as famous as tricorn hats and swashed buckles, and also one of the oldest sea shanties on record, dating back to at least the 1830s. Used mostly on larger ships, it was the only work song permitted by the Royal Navy.
Isn't it the best? It's exactly the kind of thing you imagine pirates singing, drunk off rum and swinging at the ropes. They never did, of course, since it dates back to the early 19th century, but it's an awesome tune regardless. I mean, how often do you get to hear a song about a giant ram terrorising the countryside, killing all in its path?
Cheerly Man is actually an American shanty, one of the most popular of the 19th century. The lyrics you hear in the game are the "radio edit"; 20th century author Joanna Colcord wrote the more common words "are too racy to reproduce without considerable editing."
Starting life as a Scottish fisherman's song, it soon made its way over the Atlantic and became popular in both the US and Canada. You'll notice each verse involves a creature of the sea; sailors could keep adding to the song as long as they could keep thinking of new fish with catchy words.


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MARQUETTE, Mich. – The Northern Michigan University men's basketball team fell 64-56 to Grand Valley State University on Thursday (Feb. 7) evening from the Berry Events Center. With the loss, NMU is now 5-15 overall and 4-12 in the Great Lakes Intercollegiate Athletic Conference. GVSU improves to 15-5 overall and 12-4 in conference play.
After a GVSU one-point halftime lead (30-29), the road team outscored the Wildcats 34-27 in the second half. The Lakers went on a 17-1 run in the middle of the second half to take control of the game with a 55-35 lead.
NMU then scored seven straight points in the next two minutes sparked by five points from senior forward TJ Cameron on an old-fashioned three-point play and layup. Junior forward Scooter Johnson also added a bucket in the run.
GVSU was up by 16 with 2:28 but only scored one more point down the stretch as the 'Cats drained three three-pointers in the final 1:15 to cut the final margin down to eight. Cameron hit two while sophomore guard Spencer Huss drained one.
Cameron finished with a game-high 16 points on 6-for-10 shooting, including 3-for-5 from deep. Johnson was also in double figures with 12 points off the bench. Sophomore forward Kendall Jackson added eight points and six rebounds.
NMU shot 40.4 percent (19-for-47) from the field and were 7-for-19 (36.8 percent) from the three-point line.
GVSU was led by Ricardo Carbajal with 15 points. Tyrone Lee was also in double figures with 10. The Lakers shot 50 percent (22-of-44) from the field and outrebounded NMU 31-24. They scored 21 points off of 16 NMU turnovers.
Northern hosts Ferris State on Saturday (Feb. 9). The Bulldogs lost 64-55 at Michigan Tech on Thursday. Saturday's game tips off at 11 a.m. and is the opening game of the Pink Wave. Fans are encouraged to wear pink in support of breast cancer awareness to all three NMU events at the Berry Events Center. Money raised goes to Cancer Care of Marquette County.


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Nathan Rothschild is credited with creating the stock market axiom "Buy on the sound of cannons, sell on the sound of trumpets." The phrase means that the beginning of a war is a good time to buy stocks – as there is usually a fair amount of panic leading up to war.
Through the years, investors have had every reason to avoid Israel. Surrounded by neighbors sworn to its destruction, along with a soon to be nuclear armed Iran that constantly rattles its sabers at the tiny nation of just 7.8 million people (a little less than the population of the State of Virginia).
However, investors who feared putting their money to work in a country that is under constant threat have missed out on some big opportunities. Israel is home to some of the most successful and innovative companies on the planet.
For example, Teva Pharmaceuticals (NYSE:TEVA) is the dominant player in generic drugs.
Check Point Software (NASDAQ:CHKP) is one of the leading IT security companies in the world. And the tiny country's entrepreneurial spirit has fostered many successful small cap companies like Given Imaging (GIVN), the maker of the pill camera and Elbit Systems (NASDAQ:ESLT), makes drones, remote weapons systems and other defense related products.
Other than the United States, Israel has more companies listed on the Nasdaq than any other country.
History Doesn't Repeat, But it Rhymes
But here is why you should consider investing in Israeli stocks now. While it might seem counterintuitive to invest in a country that just got finished with a nasty skirmish with its enemies – particularly one where nothing was accomplished (other than Hamas agreeing to stop firing rockets at Israeli civilians), history shows that now is the best time to invest in Israeli companies.
Over the past 12 years, if investors had the courage to invest their money at the start of hostilities (at the sounds of cannons) between Israel and the Palestinians, they fared very well, much better than if they'd invested in the S&P 500.
For example, on September 28, 2000, Israeli Prime Minister Ariel Sharon made an appearance on the Temple Mount in Jerusalem, just steps from the Al-Aqsa Mosque. This enraged Palestinian Muslims who rioted for days, leading to clashes between Israeli police and Palestinians and eventually devolving into violence between more heavily armed factions.
Late 2000 was the early stages of the dot-com collapse and Israeli stocks were not immune. However, if you had invested in the TA-100 index, the 100 largest stocks on the Tel Aviv Stock Exchange, the day after Sharon's infamous stroll, five years later, you'd be up 36%, while investors in the S&P 500 were still down 7%.
In December 2008, things got really bad between the two sides. After repeated rocket fire by Hamas into Israel, the Israeli army retaliated, eventually sending troops into Gaza.
From a financial standpoint, the world was still smack dab in the middle of the economic crisis. The collapses of Lehman Brothers and Washington Mutual were just three months old. The bear market was raging. It was a very scary time to invest anywhere, especially in a country in armed conflict whose markets are dominated by technology companies.
Yet, if you invested in the TA-100 at the sound of cannons in 2008, you would have seen a three year return of 85%, versus the S&P 500's 55%. If you still held those stocks today, you'd have doubled your money in the TA-100, a 101% return, while the S&P posted 76% gains.
And since November 14 of this year, when Israel assassinated Hamas' military leader, kicking off another wave of fighting, the TA-100 is up over 3%.
Interestingly, during the two bear markets of the past 12 years, the Israeli market bottomed first. In 2003, it bottomed about a month before U.S. markets. Surprisingly, the TA-100 bottomed in November 2008, before intense fighting began in December. U.S. stocks didn't stop falling until March 2009.
Investing in any market when there is panic is usually a good idea. And there often is panic before war breaks out. History shows that investing in Israeli stocks during the times when it's scariest is a great way to make significant profits over the next few years.
Disclosure: Investment U expressly forbids its writers from having a financial interest in any security they recommend to our subscribers. All employees and agents of Investment U (and affiliated companies) must wait 24 hours after an initial trade recommendation is published on online - or 72 hours after a direct mail publication is sent - before acting on that recommendation.


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HSBC CEO, Stuart Gulliver
John Laidlow, Head of Sustainable Business, HSBC
Sin Chuan Eng, Head of Sustainability, KLK
Jason Foong Huey Yuan, Assistant General Manager, KLK
Dear Mr. Gulliver,
I am outraged that Kuala Lumpur Kepong (KLK), an HSBC-financed company, is threatening to impose industrial scale palm oil plantations in Collingwood Bay, Papua New Guinea, against the will of the Indigenous communities whose land it is.
The nine chiefs representing the Collingwood Bay community, in a rarely issued joint communiqué, in 2010 voiced the consensus of the residents —who total over 7,000 people from 326 clans in 22 villages scattered across our coastline—that they do not wish to have palm oil plantations established on their land under any circumstances. Yet, in the past weeks, KLK has brought large earth moving equipment, a barge of palm oil seeds, and security personnel to Collingwood Bay in attempts to move forward development of palm oil plantations.
As a principal banker to KLK, HSBC has the responsibility to take urgent action and convince KLK to remove this equipment, barge, and security personnel from Collingwood Bay territory immediately and to cease all current and planned activities related to their palm oil plantation project in Collingwood Bay.
The people of Collingwood Bay are asking you to uphold HSBC's commitments to responsible palm oil finance and to not bankroll rainforest destruction and the violation of their rights, including the right to free, prior and informed consideration of major development proposals in their territories and their fundamental right to give or withhold consent.
As one of the world's largest banks and a major financier of palm oil companies, I expect HSBC to use its full leverage to prevent KLK from moving forward with its destructive palm oil plantations project in Collingwood Bay. The world will be watching.
Finally, I add my voice to the thousands of other stakeholders who are demanding that you put in place new palm oil sector finance policies which ensure that all HSBC financing is conditioned on the protection of human rights including the tenure rights of forest-dependent communities, protection of standing rainforests and the protection of carbon-rich tropical peatlands.
Rainforest Action Network
This petition closed over 5 years ago
Tell HSBC: Stop the Illegal Land Grab in Collingwood Bay!
The people of Collingwood Bay have built their culture and livelihoods around the primary forest and pristine marine environment that...
Tell HSBC: Stop the Illegal Land Grab in Collingwood Bay!
The people of Collingwood Bay have built their culture and livelihoods around the primary forest and pristine marine environment that surrounds their community in Papua New Guinea.
Now their way of life and ancestral lands are under attack by palm oil giant KLK. They've brought their complaints to the Roundtable on Sustainable Palm Oil (RSPO), the organization which is supposed to stop illegal land grabs, but the response from the RSPO has been slow. Meanwhile KLK has continued to push its agenda—landing a barge with palm oil seeds and security personnel in Collingwood Bay.
It's time for this to stop. HSBC is a principal bank to KLK, and has the power to stop this entire land grab in its tracks. Will you take a moment to send HSBC a note, demanding that they take immediate action to halt KLK's theft of the Collingwood Bay community's land?


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I have been noticing 911tm.9bb.ru lately linking to CluesForum and one of my initial thoughts, of course, was, "Oh no, here we go again ... more of the PumpItOut/FlyingTelephant/Jeff Hill/LetsRollForums.com-style nonsense?"
But after struggling through some poor efforts of Google Translate, I think these people may be really onto something.
Here are just a couple examples of the fake pictures they have uncovered in connection with strange stories circulating in Russia:
The alleged "Sinai Air Bus" crash:
And regarding the quick work made for alleged victims (vicsims?) of Russian crash FZ981:
https://translate.google.com/translate? ... 6%26p%3D13
The comments when translated are quite interesting, and so the link above is the cruddy Google Translate.
To 911tm.9bb.ru, hello and salutations to our intelligent peace-loving friends in Russia! And thank you for helping to teach the world to use brain power! (May we in good humor also politely warn you not to trust the intentions of Phil Jayhan/LetsRollForums and to be very careful about the YouTube intelligencia?)
In any case, brothers and sisters in Russia, thanks for linking to CluesForum!


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With big names like Ben Kingsley, Guy Pearce, James Badge Dale and Rebecca Hall joining returning series veterans Robert Downey, Jr., Gwyneth Paltrow, and Don Cheadle, Iron Man 3 is shaping up to be a promising new entry in the popular film series. By comparison, it seems almost trivial that obscure actor Ashley Hamilton is apparently in talks to play equally obscure Iron Man villain, Firepower. Then again, it's unclear how, exactly, this character fits into the larger story line based on the Iron Man "Extremis" storyline, leaving open the possibility that Firepower will, in fact, play a pivotal role.
In other Iron Man 3 news: Former franchise helmer Jon Favreau confirmed on Twitter that - while he won't be directing the threequel - he will be returning to the franchise as Tony Stark's bodyguard, Happy Hogan.
Ashley Hamilton is probably best known for playing recurring character Cole Deschanel on the soap opera series Sunset Beach in 1997, before being replaced by actor Eddie Cibrian. Hamilton also earned attention for his brief marriage to actress Shannen Doherty, which ended in divorce after only five months. None of this exactly recommends him for the role of a super villain in an A-list Hollywood production. In fact, the closest he's come to that was playing a bad guy in the family comedy sequel Beethoven's 2nd, back in 1993. A big reason for Hamilton's possible involvement in Iron Man 3 likely has to do with the fact that, according to Variety, Robert Downey, Jr. is a close friend.
Firepower is an experimental battle suit much like Tony Stark's Iron Man armor. It was originally designed and worn by Jack Taggert for the purpose of defeating the superhero, and has more recently been seen in the service of Iron Man nemesis The Mandarin.
If nothing else, the presence of Firepower indicates a certain level of deviation from Warren Ellis' six-issue Iron Man: Extremis comic book series, which reportedly provides much of the basis for Iron Man 3's plot (Firepower wasn't in Ellis' version). Of course, Shane Black and company never claimed to be making a direct adaptation of Extremis, which would be difficult to pull off without earning an R-rating, given the storyline's often brutal, graphic violence. All that's really known is that the film will incorporate certain elements from Ellis' series, and possibly subsequent stories featuring the titular nanotechnology.
Sources close to the production still maintain that Ben Kingsley will NOT be playing The Mandarin, no matter how much fans of the comics may want him to. Kingsley WOULD be a perfect fit (despite not being part-Chinese), and the Mandarin DOES unleash the Extremis technology in a more recent storyline, but the actor has apparently already signed on for a different role in the film.
Iron Man 3 is scheduled for release on May 3rd, 2013.
Sources: Variety


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Ever since the announcement that Argo star and director Ben Affleck had signed on to a multi-film deal as the new Batman to first appear in the tentatively titled Batman vs. Superman (or, conversely, Superman vs. Batman), people have been jokingly asking whether Affleck's friend and frequent screen partner Matt Damon would join him as Batman's faithful sidekick, Robin the Boy Wonder.
Obviously "Boy Wonder" would be a little bit of a stretch for Damon, who turns 43 this fall, but the idea wasn't entirely impossible. Since Superman vs. Batman will be an adaptation, director Zack Snyder and screenwriter David S. Goyer could have taken some liberties with the source material and incorporated Robin into the movie as a slightly more mature partner in crime-fighting for Batfleck.
While Robin might still make an appearance in Batman vs. Superman, we must sadly report that he won't be played by Matt Damon. Speaking to the Times of India, the actor laughed off the idea, explaining that he just can't imagine a middle-aged Robin:
"I am a little older than Ben. I never saw Robin as older than Batman. Somebody sent me a picture actually [see the photoshopped picture above]. It was really funny. But it's safe to say I won't be Robin."
You may or may not know this, but not everyone on the internet has been pleased by the Batfleck casting. As well as the standard Change.org petition demanding that he be removed, a group of Batman fans have even pleaded with the White House to make it illegal for Ben Affleck to play any more comic book characters. The latter petition was recently removed from the site, which could either be considered a slap in the face of democracy or a sensible response to a really silly request.
Screen Rant already covered some of the reasons why this casting choice could be a good thing in both Andrew Dyce's editorial and the latest SR Underground podcast, but Damon didn't hesitate to poke this particular controversy with a stick:
"I think it will be great. It will be terrific. I know there are a lot of people grousing on the Internet. I just think it's kind of funny. You know, he's not playing King Lear. It's Batman! Certainly within his skill set. If anybody saw 'Argo' or 'The Town,' and all the work he's been doing lately, it's way more nuanced and interesting and way more difficult than Batman! Batman just sits there with his cowl over his head and whispers in a kinda gruff voice at people. Bruce Wayne is the more challenging part of the role, and Ben will be great at that."
Someone had better equip Damon with a flame shield for badmouthing the Bat, though admittedly the character does do quite a bit of sitting around with a cowl on his head and whispering in a gruff voice. With that in mind, Affleck does seem to be more naturally suited to the other half of Batman's personality: the outwardly affable and carefree playboy with a troubled past and a dark side that he keeps hidden.
Since Batman vs. Superman is still so far off, we can have some fun with the idea that Damon only said he won't be playing Robin, and not that he won't appear in the film at all. Though the two actors haven't appeared in a movie together since 2004's Jersey Girl, they share great screen chemistry and also jointly won an Academy Award in 1997 for their Good Will Hunting script. Perhaps Damon will make an appearance in Batman vs. Superman, if only a cameo.
Damon might be out of the running, but would you be interested in seeing Robin team up with Batman against Henry Cavill's Superman? Tell us in the comments which other characters from the DC universe you're hoping to see in the Man of Steel sequel.
Batman vs. Superman will be released on July 15, 2015.
Source: Times of India


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From now to 31.3.2021, in memory of Bhau, our vision changer, founder Sanjay Moreshwar Bapat sponsors all 258 countries, SARs, Islands, Territories and 29 States, 1 NCT, 6 UTs & 726 plus districts in India
You can pay a mutually agreeable donation for the banner below. It enhances your image. It will be used for development issues, our global examples and Brand Thane The donation is to Developed Nation Network Trust, our NGO with 80G and FCRA.
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The Center for Celiac Research and Treatment is dedicated to improving the quality of life for patients with celiac disease, while learning the cause of the disease and finding a cure. The Center provides comprehensive clinical care and long-term support for adults and children who suffer from celiac disease. Celiac disease, a genetically based autoimmune disease, affects 1 out of every 133 people in the United States. Learn more about the mission of the Center for Celiac Research & Treatment.
Led by Dr. Alessio Fasano, the Center includes a multidisciplinary team of gastroenterologists, pediatricians, dieticians and nurses who work together to develop individualized treatment plans for people with celiac disease.
Celiac patients and their families also receive life-style counseling and dietary support to help them avoid foods containing gluten.
Through ongoing research and clinical trials, the Center is helping health care professionals to recognize celiac disease and helping celiac patients to better manage their symptoms.
Center scientists are working to develop a cure and an alternative treatment to the gluten free diet. In addition, the Center is investigating possible links between celiac disease and other autoimmune diseases.
The Center for Celiac Research and Treatment at MGHfC is currently recruiting for an exciting research study known as the CDGEMM study! Newborns and infants who have a first-degree relative (father, mother, or sibling) with diagnosed celiac disease are eligible to participate. This multi-center effort is aimed at identifying patterns in gut bacteria that may one day be able to predict and/or prevent the onset of celiac disease.
The Mucosal Immunology and Biology Research Center (MIBRC) conducts basic research in the field of mucosal immunology. Currently, nine primary investigators work on related issues ranging from Salmonella food poisoning to intestinal inflammatory diseases and the associated immune-mediated conditions. Learn more about the Mucosal Immunology and Biology Research Center.
News coverage featuring Maureen Leonard, MD, MMSc, of the MassGeneral Hospital for Children Center for Celiac Research and Treatment.
For the Celiac Center for Research and Treatment, this coming January marks 20 years of research breakthroughs and patient care and four years since moving to Boston. Alessio Fasano, MD, director of the Celiac Center, reflects on his team's accomplishments over the past two decades and the high standard of care he delivers to patients every day.
The Center for Celiac Research and Treatment at MassGeneral Hospital for Children celebrated a milestone Aug. 5, when new Food and Drug Administration standards for gluten-free labeling went into effect.
In this news segment with Dr. Mallika Marshall from WBZ-TV Boston, Dr. Alessio Fasano, joined by patient Sharone Jelden, talks about diagnosis and treatment for celiac disease and who benefits from following a gluten-free diet.
Overuse of popular NSAIDs is associated with intestinal permeability, which is a condition associated with celiac disease and other autoimmune disorders. Dr. Alessio Fasano, director of the Center for Celiac Research at MassGeneral Hospital for Children, discusses the implications of using popular pain medication in relation to gluten-related disorders and exercise.
People with celiac disease and other gluten-related disorders soon will have something to celebrate with the recent launch of the Celiac Program at Harvard Medical School. Advancing basic and clinical research is the main goal of the partnership of experts in celiac care from Massachusetts General Hospital, Beth Israel Deaconess Medical Center and Boston Children's Hospital, along with collaboration in clinical and training initiatives.
Dr. Alessio Fasano, director of the Center for Celiac Research at MassGeneral Hospital for Children, separates the myths from the realities about the gluten-free diet in this video with Huffington Post science editor Jacqueline Howard.
Transcending the disciplines of microbiology, molecular and cell biology, and physiology, Dr. Alessio Fasano's research focuses on the mucosal biology of the gut. By focusing on the "cross talk" between enteric pathogens and their hosts, Dr. Fasano's group has elucidated various organs and cell functions involved in health and disease, including inflammatory and autoimmune disorders.
Calling for action on the final steps before implementation of safe gluten-free labeling regulations, Dr. Alessio Fasano joined Rep. Nita Lowey (D-NY) in an Op-Ed published in the Huffington Post Healthy Living section on April 3.
New York Times article features Alessio Fasano, MD, of the Center for Celiac Research & Treatment at MassGeneral Hospital for Children.
The Center for Celiac Research, under the leadership of Alessio Fasano, MD, has moved from Baltimore to Massachusetts General Hospital for Children (MGHfC) in Boston.
Prominent celiac disease and gluten sensitivity researcher Dr. Alessio Fasano says he's "confident" that a clinical trial now underway will pinpoint a biological marker, or biomarker, for non-celiac gluten sensitivity, and that discovery should pave the way for the development of diagnostic tests for the condition.
Dr. Alessio Fasano, director of the Center for Celiac Research, provides guidance on the use of probiotics in the treatment of people with Autism Spectrum Disorder at autismspeaks.org.
Dr. Alessio Fasano, director of the Center for Celiac Research, speaks with Jules Shepard on The Gluten Free Voice Radio Show to discuss the Center's future and the move to MassGeneral Hospital for Children.
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A study of a new drug for advanced skin cancer has shown it "almost doubles survival times", BBC News has reported.
The drug, called vemurafenib, was tested in a clinical trial that examined its impact on tumour size and survival in patients with advanced melanoma skin cancer that had spread to other parts of the body. The outlook for this type of cancer is generally poor as it's an aggressive cancer with few treatment options and patients tend to survive for less than a year. Researchers found that approximately half of the patients responded to the drug and that the overall survival rate in these patients was nearly 16 months, on average.
This study provides evidence on the effectiveness of a new drug, vemurafenib, for treating some patients with metastatic melanoma. Because the drug works by targeting a specific genetic mutation, it won't be suitable for patients who aren't carrying the mutation, which is found in around half of patients with melanoma that has spread. Additionally, while the drug has been recommended for approval, it hasn't yet been approved for use in Europe; it is unclear at this point if and when it will be available for treatment in the UK, although the National Institute for Health and Clinical Excellence (NICE) is said to be currently assessing it.
Where did the story come from?
The study was carried out by researchers from Vanderbilt University, the Hoffman-La Roche pharmaceutical company and other institutions throughout the US and Australia. The research was supported by Hoffmann-La Roche, who are the manufacturers of vemurafenib.
The study was published in the peer-reviewed New England Journal of Medicine.
The BBC covered this research appropriately, emphasising the positive results but also highlighting that the drug had yet to be approved in the UK and wouldn't be suitable for all patients with metastatic melanoma. The broadcaster also reported on some of the limitations of the research methods.
What kind of research was this?
This was a phase II clinical trial that examined how effective a drug called vemurafenib was at inducing a clinical response and its impact on overall survival in a set of patients with metastatic melanoma. Malignant melanoma is a relatively rare but aggressive type of skin cancer that can be particularly hard to treat when caught at an advanced stage. All of the patients in the trial carried a specific genetic mutation called the "BRAF V600 mutation", which leads to the abnormal activation of an enzyme involved in cell growth and death. Previous research indicates that vemurafenib blocks the action of this enzyme.
Phase II trials are designed to assess the effects of new drugs in highly controlled settings. These trials don't normally employ a group of control patients receiving other forms of treatment, and so generally can't be used to tell how a new drug compares against standard or existing treatments. These types of control-group comparisons are usually performed in phase III trials. Phase II trials are, however, a key part of the development of new drugs, and are used as a confirmatory step before a drug can be given to wider research populations.
Media coverage of this trial has compared the survival rates of patients receiving vemurafenib with those seen in general patients with metastatic melanoma, rather than patients directly involved in the study. While such comparisons are useful for readers to understand more about the drug, formal scientific comparisons of different treatments have to account for a range of important factors, such as patients' medical histories or how advanced the cancer is when treatment is started.
What did the research involve?
Researchers enrolled 132 patients with stage IV metastatic melanoma (stage IV cancer means it has spread to other parts of the body, such as the lungs or liver). They all carried a form of BRAF V600 genetic mutation. All patients had previously been treated for the disease, and they all received the same dose of the drug vemurafenib twice a day. The patients stopped taking the drug if they experienced unacceptable side effects or if their disease progressed.
The patients underwent tumour imaging (either magnetic resonance imaging (MRI) or computed tomography (CT)) at the beginning of the study and every six weeks thereafter. Researchers used these scans to assess any changes in tumour size and response to the treatment.
Researchers then analysed the data to determine the proportion of patients who responded to treatment.
What were the basic results?
The patients were followed up for an average (median) of 12.9 months. The researchers found that:
- Overall, 53% of patients showed some reduction in the size of their tumour measured at the start of the study.
- Among those that responded, eight patients achieved a complete response (6% of the total study group), and 62 patients (47%) achieved a partial response (47% of the total study group).
- Of the patients who responded to treatment, 23 (33% of responders) maintained that response at the end of the study.
- The median duration of response was 6.7 months (95% CI 5.6 to 8.6 months).
- Median overall survival was 15.9 months (95% CI 11.6 to 18.3 months), and 62 patients (47%) were still alive at the end of the study.
- The overall survival rate at six months was 77% (95% CI 70% to 85%), at twelve months was 58% (95% CI 49% to 67%,) and at eighteen months was 43% (95% CI 33% to 53%).
Most patients experienced at least one side effect due to the study drug. The most commonly reported side effects were joint pain, rash, fatigue, sensitivity to light and hair loss. Four patients (3%) stopped taking the drug due to side effects. One patient died due to a rapid progression of the melanoma along with kidney failure; the researchers said this may have been related to taking vemurafenib but this was not certain.
How did the researchers interpret the results?
The researchers concluded that vemurafenib effectively targets metastatic melanoma tumours in patients with BRAF V6000 mutations, and that response rates are higher than those seen with other treatments.
This study has shown that patients with a specific mutation and advanced metastatic melanoma have a high response rate to a new drug, vemurafenib. Currently, treatment options for people with metastatic melanoma can involve chemotherapy, radiotherapy or immune therapies, but even with treatment the outlook is usually poor once their cancer has spread. Often, people with late-stage disease may be enrolled in clinical trials such as this to try and find more effective treatments.
Researchers say that the long follow-up of their study provides initial evidence on the overall survival of patients receiving this drug, something that phase III studies have so far not been able to demonstrate.
Researchers point out, however, that patients do develop resistance to vemurafenib, and that further research is needed to determine how this occurs.
Previous studies have shown that patients with metastatic melanoma have an average survival rate of 6 to 10 months, as mentioned in some news coverage. However, it is difficult to compare this estimate to survival times seen in the current study, as the patient populations may be different. For example, it's unclear whether these studies enrolled patients with the same genetic mutation, or how survival may be different between those with and without the mutation.
This study adds to the mounting evidence of the effectiveness of vemurafenib as a treatment of metastatic melanoma with BRAF V600 mutation. While this phase II study cannot directly demonstrate effectiveness compared to standard care, an additional phase III study has been conducted that randomised patients to receive vemurafenib or standard therapy. This study was stopped before it was complete, as an interim analysis indicated that vemurafenib significantly improved patients' progression-free survival and six-month survival, compared with standard care. At this point, all of the participants were given the new drug.
All in all, this is very promising research for the treatment of an aggressive cancer for which there are few existing options. At present the drug has been recommended for approval by the European Medicines Agency, and is currently being evaluated by NICE for use in the UK.
Analysis by Bazian
Edited by NHS Website
Links to the headlines
Skin cancer drug hopes raised by study
BBC News, 23 February 2012
Links to the science
Sosman JA, Kim KB, M.D., Schuchter L et al.
Survival in BRAF V600 Mutant Advanced Melanoma Treated with Vemurafenib
New England Journal of Medicine 2012; 366:707-714


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9 units of Lutron motorized shades
We know that sometimes choosing the perfect window treatments is not as easy as it sound. When you come to Alluring Window, though, you have our expert designers at your service. Additionally, because we know how busy your life is, we're always happy to schedule your free consultation appointment to fit your calendar.
One of our experts will be in touch with you within 24 hours


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"Corbet, a noble Norman, came into England with the Conqueror, and from his son Roger Corbet descended the baronial house, as well as the families of the name now existing." [2]CITATION[CLOSE]
Lowe, Mark Anthony, Patronymica Britannica, A Dictionary of Family Names of the United Kingdom. London: John Russel Smith, 1860. Print.
Another source notes "a Norman family too well known to need any detail. Hence the Barons Corbet of Caux, and the Baronets Corbet." [3]CITATION[CLOSE]
The Norman People and Their Existing Descendants in the British Dominions and the United States Of America. Baltimore: Genealogical Publishing, 1975. Print. (ISBN 0-8063-0636-X)
|Popular Products
|Armorial History With Coat of Arms
|Coat of Arms & Surname History Package
|Family Crest Image (jpg) Heritage Series - 300 DPI
|Coffee Mug
|Armorial History with Frame
|Framed Surname History and Coat of Arms


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LOS ANGELES, Sept. 10 (UPI) -- The Arena Football League's Los Angeles team, KISS, said it has offered recently cut NFL quarterback Tim Tebow a three-year deal.
The team, which is co-owned by the rock band of the same name, said Monday the contract offers the possibility Tebow could make millions, the Los Angeles Times reported.
"As a former NFL player, the LA KISS will offer intense training and unwavered commitment to the former New England Patriots player, with the hopes to take him to the next level," a statement from the team, which is slated to start play in 2014, said.
Tebow has not said whether he is interested in the deal.
Paul Stanley and Gene Simmons, of KISS, also said they support Tebow joining the team.
"His exciting style of play would definitely send shock waves through the league. We're excited for the opportunity to see him with an LA KISS uniform on, and for the LA KISS fans to be rocking their Tebow shirts and jerseys," Simmons said in the statement.


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Chad0804 necesitaba un nuevo diseño de logotipo y lanzó un concurso de diseño en 99designs.
Un ganador ha sido elegido entre 245 diseños de 50 diseñadores freelance.
Blue Chip Realty
Hard working real estate professional looking to start a real estate brokerage and construction company. I have been in the new home sales industry for over 10 years building and selling upper end homes for some of the most successful people. The culture for both of these companies is focus on service and taking the best care of our clients. We expect referrals to account for 85% of our business due to the experience of working with our team.
Mid to high end homeowners who need to sell or move up! 25-60 year old professionals who appreciate good service and always keeping their best interest in mind.
I am looking for a logo that is memorable and stands out. (cutting edge, clean and fresh) I would like a logo that can be used for both companies (Blue Chip Realty and Blue Chip Construction) by just switching Realty and Construction in and out. Please focus on Blue Chip Realty for the design purposes. I am certainly open to new concepts and LOVE to think outside the box. I am looking for something abstract that also demonstrates luxury. If you need more info, please feel free to contact me. I appreciate your efforts and look forward to seeing your designs!
Descubre cómo funciona un concurso de diseño u obtén más información sobre nuestros servicios de diseño de logo.


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Ginsu Shoku Series Anodized Cutlery Set - 8 pc. - Ebony
Product Details
About this item
Add color and elegance for a contemporary style.
current price: $198.82
Online only
Ginsu has always been known for sharp blades, but now they are bringing that sharpness to the world of color with their new Shoku anodized cutlery set. Ginsu Shoku series blades are made of Japanese stainless steel that is well known for its stain- and rust-resistence, strength, and its ability to hold an incredible sharp edge. Crafted with Ginsu's quality materials and workmanship, what really sets these knives apart is the unique anodizing process on the handle, which adds color and elegance for a contemporary style that will complement any kitchen envirornment. When not in use, the Shoku knives are safely and conveniently displayed on a stainless magnetic storage strip. By using the magnetic strip to store the knives, it frees up valuable counter space in any kitchen. As with all fine cutlery, hand wash and dry immediately for long lasting use.
Policies & plans
Fully forged Japanese steel blades that are percision balanced for optimum cutting. The unique anodized process on handle brings color and elegance into any kitchen enviornment.
Set includes:
Set includes:
- 8" Chef Knife
- 8" Bread knife
- 7" Santoku
- 5" Boning Knife
- 3.5" Paring Knife
- Honing Rod and magnetic strip
Limited Lifetime
Assembled Country
Assembled Size
18.25"L x 4.5"W x 5.25"H
Component Country
Shipping Info
Standard - 2 to 6 business days
Premium - 2 to 4 business days
Express - 1 to 2 business days


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U.K.'s Osborne Gets His Man for Top Bank Role
Chancellor George Osborne viewed Canadian Mark Carney as a top choice to succeed Mervyn King as the governor of the Bank of England, says Heard on the Street's Simon Nixon. He assesses Mr. Carney's immediate challenges on taking up the post. Photo: Getty Images
This transcript has been automatically generated and may not be 100% accurate.
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Step 1
Be sure you are ready to do the required work when you adopt a highway in New York State. You and your team will have to pick up litter along your adopted highway, which is usually a stretch two miles long, four times a year for two years.
Step 2
Contact your county's Adopt-A-Highway coordinator to find out which sections of highway are suitable and available for adoption. In most cases you can adopt any section that is not already adopted, but sometimes an area may be deemed unsuitable because of volume of traffic or dangerous design.
Step 3
Complete and submit a Highway Work Permit from the New York State Department of Transportation. Your county's Adopt-A-Highway coordinator will provide you with the form, and you will not have to pay the standard permit fee.
Step 4
Prepare for some well-deserved recognition. Once the permit is signed, the New York State Department of Transportation will notify the local media of the adoption and erect a sign in your honor along your section of adopted highway.
Step 5
Attend the required safety briefing conducted by the New York State Department of Transportation and receive the necessary orange safety gear and trash disposal bags.
Step 6
Begin your honorable work cleaning up your adopted highway!
Fact BoxThings you'll need
¯New York state highway
¯Work permit
¯Orange safety gear
¯Trash bags
¯Minors between the ages of 12 to 18 may participate in the Adopt-A-Highway program as long as they are supervised by an adult. There must be one supervisor for every six minors.
¯Bring enough bottled water for all group members. Working hard in the sun can result in dehydration.
¯Never pick up hazardous materials.
¯Do not engage in horseplay while picking up litter. You will endanger yourself and distract drivers.
¯Always wear the provided orange safety gear. It is important for drivers to be able to see you.


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White: We're so excited about album
Saturdays star Vanessa White has revealed the band are staying true to their pop roots on their next album.
The girlband - who are currently hard at work trying to crack the US market - have been laying down tracks for their upcoming record, The Chase.
Vanessa said: "It's been a really fun process. We got to work with some amazing producers and writers out there so we're really excited about this one."
The Ego singer added of the group's sound: "We've always kind of kept it really similar because at the end of the day we are a pop group and we always say it's so nice to be a pop group... I think it always is a progress of what we have done before. I guess it's a little more grown up, we've grown up and we've been together for five years now."
The success of fellow British acts such as One Direction and The Wanted has given the girls a confidence boost in their bid for Stateside success, Vanessa said.
"It's lovely for us because The Wanted actually supported us on one of our shows when they were starting out, so it's nice to see they've done so well and to have our mates out there, it's cool."
Meanwhile, Vanessa and her bandmates are encouraging the nation to let its lighter side out for Red Nose Day with Maltesers and help raise more than £1m for Comic Relief.
"Whenever we can help out with charity we love to get involved. We're just really lucky to be in the position we're in that we're able to help," Vanessa explained.


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It's hard to say which is more cringe-worthy: President Barack Obama's debate performance last week or his efforts to control the damage by poking fun at himself. In Los Angeles on Sunday night, Mr. Obama recognized Stevie Wonder and Katy Perry as "incredible professionals" who "perform flawlessly night after night." Then he added, "I can't always say the same."
Later that night, he spoke of taking his wife out the night before for a late celebration of their wedding anniversary, postponed because the debate fell on the actual anniversary date. "There was some speculation as to whether [the anniversary] had an impact on my performance," he said.
That could have been a reference to the "Saturday Night Live" sketch that had depicted a distracted and henpecked Obama more worried about buying a gift for his wife than debating Mitt Romney. Is it possible the president and first lady returned home from their delayed anniversary dinner Saturday, turned on the TV and saw this bit of comedy? Is it possible that Michelle then put on her footy pajamas and went to bed in the guest room?
There's a history of incumbent presidents losing debates to fresher-faced challengers. Many even go on to win the election, such as Ronald Reagan, who had his posterior handed to him by Walter Mondale in 1984, and George W. Bush, who was deemed the loser in a debate with John Kerry in 2004 and kept his job anyway.
But dismal numbers this week, particularly those from the Pew Research Center showing that Mr. Obama handed Mitt Romney 12 points virtually overnight among likely voters, suggests that Mr. Obama's job is far from secure.
That could change, of course. At the next presidential debate Tuesday, the president could morph into the Incredible Hulk. But for now, the president's every move is spotlighted by the sallow glow of a particular kind of failure.
It's not the broad-spectrum failure that goes along with not being able to pass legislation or jump-start the economy into full-speed growth. Nor is it the personal, localized failure associated with not being able to quit smoking or being a terrible bowler.
No, this is a special breed of failure, involving not just embarrassment but humiliation, a failure in which there is no one to blame but yourself because you're the one who put yourself on that stage. It's the failure that comes from bombing.
The president bombed. Like a stand-up comic whose audience heckles him off the stage midroutine, he bombed big time. Given his pedantic speaking style, his downward gaze and his utter lack of enthusiasm, he might as well have tapped the mic and asked the signature bombing question: "Is this on?" Given the excoriating tweets, the clucking commentators, the gob-smacked Democrats and the gloating Republicans, he might as well have done the comedian-like thing and retreated to the nearest dive bar to drown himself in Wild Turkey while wondering whether it's too late to go to law school (an especially sad scenario given that the president already went to law school).
For all his flaws and mistakes, Mr. Obama has managed to live his life with very few screw-ups, at least by political standards. He appears to be almost maddeningly free of personal scandals. His risk-averse, highly calculated approach to decision-making has given him a reputation for playing it safe rather than making a splash.
But consider this: The fact the president's performance wasn't merely mediocre but truly, deeply bad could actually work in his favor. That's because there's something beautiful, even liberating, about bombing. It's a rite of passage, a painful, character-building learning experience. There is no successful comic who hasn't bombed. There is no musician who hasn't tried out a new song, only to watch half the audience get up to go to the bathroom. To err is human, to bomb is to feel superhuman — when you make a comeback.
So maybe it's time for Obama supporters to stop whining and learn to love this particular bomb. Though if he falls flat again, even a Hulk costume might not be a bad idea.
Meghan Daum is a columnist for the Los Angeles Times. Her email is email@example.com.


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Create an Account - Increase your productivity, customize your experience, and engage in information you care about.
In 2012, the Town of Carrboro hosted Community Dialogue Sessions designed to increase community awareness and knowledge of our affordable housing situation in Carrboro. During these sessions, the Town was able to gain residential input on goals and strategies for how to address affordable housing issues in Carrboro, which were incorporated into the Town's adopted Affordable Housing Goals and Strategies. You can find information from each session by clicking on the tabs on the left.


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Pete Treloar necesitaba un nuevo diseño de banner publicitario y lanzó un concurso de diseño en 99designs.
Un ganador ha sido elegido entre 51 diseños de 20 diseñadores freelance.
The Born Leader
When I thought about creating The Born Leader, it came to me immediately that in order to really be a Born Leader, you have to have 3 things in place; Pursuit, Passion, and Purpose.
The Pursuit of what it is that you do…your business or job. What funds your life and your future?
The Passion to live life on your own terms, exactly as you have dreamt it should be. Are you living your life how you've envisioned it?
Finally, what is your Purpose? We all have one. For me, it is my Children's Project. I know that I was put on this earth to help eliminate prejudice in our children. It is my Purpose, what is yours?
Eventually our Purpose becomes our "Reason Why" but in order to get to that point, there must be the "Pursuit" of what we want to achieve or do; many times to Learn, fund the Purpose or to lend our credibility or gained knowledge to it, as well as the ability to live with "Passion" because we deserve it, we live what we say, and truly it is what was meant for each of us.
Pursuit –Passion-Purpose that is what Born Leader is all about, that and changing the world…yours, mine, ours.
Welcome to an Amazing Life!
Karen Schaefer
The Born Leader Mentor
Small Business Owners & Entrepreneurs, Authors, Speakers, Coaches.
People with an existing or new product and are looking to make a positive impact on the World.
Job: to create a unique banner header design for a company called http://www.thebornleader.com - based off of the info below.
Integrate the attached picture (Karen in Blue Suit)
Main Title: "The Born Leader"
Sub Title: "...When You,re Ready To Change The World"
Small text: "TheBornLeader.com" "Pursuit, Passion & Purpose"
Colors: A mix of deep royal Blue and Bold Yellow that denotes success, power and authority.
Dimensions = 728 x 200
OPt-in Box: Include box for collecting "First Name, Last Name and email" & "Get your 90 Day Plan to Changing the World ($197 value)" - Include a small graphic of an e-book cover titled "The Born Leader" "...When You're Ready To Change The World" "Pursuit, Passion & Purpose" [use the same graphics as the banner]
For examples of like-designs - see header on pages below.


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About the conference
Agile Australia was founded in 2009 as an annual Conference. Since then, not only has the Conference grown to welcome over 1,200 delegates each year as well as high-profile speakers from around the country and the world, but Agile Australia has also become much more than a Conference. AgileAus is a hub for the Australian agilist community and those interested in better ways of working.


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Last week Zac gave us a great look at new car features that are destined to get tired pretty quickly. Obviously, this is not the first time this has happened — car companies have a tendency to throw every new technology against the wall to see what sticks.
Let's flash back to 1981, where the Datsun 810 Maxima makes this pretty apparent. It freaking talks to you, man! This was the first ever car with a tiny, shock-resistant phonograph record player built in that issued various vocal warnings about what the car was up to.
Don't know if you left the door open? No worries, the Datsun is here to let you know. It was a very clever and innovative idea for its time.
I have never owned an 810 Maxima (later called just "Nissan Maxima") or the 280ZX, which had the same system, but I'm going to go ahead and guess that it got old really fast. After all, talking cars didn't catch on, did they? Oh well, even if you weren't a fan of the car's voice, you still got a good-looking Japanese luxury car with rear-wheel-drive and a straight-six engine. Not a bad combo at all if you ask me.
Do any of you have experience with talking Datsuns?