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Food And Wine Concert Lineup
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Two security personnel were killed and at least 13 injured in the latest clash in North Waziristan on Wednesday. The casualties took place when militants attacked the ISA check post in North Waziristan. Four militants, which included three Uzbeks and a German, were also killed in the clash. This is the second attack on Pakistan army personnel in North Waziristan in the past seven days. On Friday, seven soldiers, including an officer were killed and at least 16 injured as militants ambushed an army convoy in North Waziristan. According to local sources, many of the Taliban groups had fled from South Waziristan and moved to North Waziristan. Many of these groups include Chechen and Arab fighters as well.
Our Staff Reporter
9:19 PM | April 28, 2010


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Including Cumbernauld, Coatbridge, Airdrie, Motherwell, Wishaw, Bellshill, Kilsyth, Shotts and surrounding towns and villages.
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Image Taken from CaimanBarbudo Cuba
Curiosity – Did you know that Radio Reloj is the only Cuban radio station that broadcasts news every minute, 24 hours a day & live ? It is also the only station in the country that transmits (at 12 noon and 12 o'clock at night) the time of more than twenty capitals of the world. LISTEN TO IT HERE
Related: JOURNAL ARTICLE / BRAIN DRAIN POLITICS: THE CUBAN MEDICAL PROFESSIONAL PAROLE PROGRAMME
Oiginal post /
Cuba"s President Miguel Diaz-Canel denounced Saturday attempts to impose the Cuban Medical Parole Program, established by the U.S. government of George W. Bush (2001-2009) and repealed by that of Barack Obama (2009-2017).
'They are trying to impose a perverse resource to stimulate brain drain. One more anti-Cuban campaign, which reveals imperial impotence in the face of revolutionary conquests. Its promoters cannot favor a civilized relationship, they are blinded by the arrogance #SomosCuba', wrote the Head of State in his Twitter @DiazCanelB.
Continue reading "Cuba Denounces Program to Stimulate its Doctors' Brain Drain – Via Radio Reloj Cuba"


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Malcolm Forbes Not Saying If He Will Write Off Party on Taxes
NEW YORK (AP) _ Malcolm Forbes is being vague about whether he plans to seek a tax write- off for his Moroccan ″party of the century,″ but opponents of a tax break are indignant at the idea of it.
″If this party were to be tax-deductible it would be a perfect example of how the tax system is unfair to the average citizen and benefits the rich,″ said Michael Waldman, director of Public Citizen's Congress Watch, a Ralph Nader organization.
The magazine publisher's 70th birthday party in Tangier on the north coast of Africa last weekend featured 600 belly dancers, 200 Berber horsemen, pigeon pie served under elaborate tents and a guest list that included Liz Taylor, Henry Kissinger, Walter Cronkite, Lee Iacocca, Rupert Murdoch, Barbara Walters, Beverly Sills and Donald Trump.
Guests were flown across the Atlantic on three jets, including a chartered supersonic Concorde. The party's expense has been estimated at $2 million to $3 million.
Rep. Fortney ″Pete″ Stark, D-Calif., released a letter to Internal Revenue Service Commissioner Fred T. Goldberg on Tuesday saying he hopes the party is not deductible.
″The public's support of the tax system is destroyed by reports of tax- deductible birthday bashes by belly-dancing billionaires,″ he wrote.
Forbes magazine officials failed to return repeated phone calls Tuesday seeking comment. The Washington Post on Monday quoted Forbes as saying that ″some of it is a business expense.″
″When you invite 300 CEOs that you do business with, you want to make a good impression,″ Malcolm Forbes Jr., who is the publisher's eldest son and the magazine's president, told The New York Times in an article Monday. He said any deduction would be worked out by company accountants. The IRS declined to comment on the tax-deductibility of the party but a spokesman pointed to pertinent sections of the tax code.
Section 262 says that aside from a small exception involving telephones, ″no deduction shall be allowed for personal, living or family expenses.″
The IRS generally considers birthday parties to be personal expenses, said Sid Weinman, an attorney and senior editor of Federal Tax Coordinator, published in New York by Research Institute of America.
Section 274 says no deduction is allowed ″with respect to an activity which is of a type generally considered to constitute entertainment, amusement, or recreation, unless the taxpayer establishes that the item was directly related to or ... associated with the active conduct of the taxpayer's trade or business.″
The Forbes bash might be viewed as a more lavish version of the parties for advertisers that most magazines give - and write off - since the companies run by many of Forbes' guests also place ads in his magazine.
Still, Weinman said, ″My guess is they'd have a hard time establishing that the shebang over there was directly associated with the magazine's business.″
Even if Forbes managed to clear that hurdle, he still would face a hurdle in Section 274 that disallows spending in ″amounts which are lavish or extravagant under the circumstances.″
The billionaire balloonist hurt his own cause on that question when he told reporters, ″We probably all do things in our lives that are not essential. I don't feel guilty about it. I feel grateful we can do it.″
″Why should Malcolm Forbes be able to deduct his birthday party in Morocco just because people he does business with were there, when I can't deduct my birthday party at the local pizzeria when I go out with people I work with?″ asked Waldman, of Congress Watch.
″This would be the ultimate proof of Leona Helmsley's dictum that the rich don't pay taxes, only the little people do,″ Waldman said, referring to the self-proclaimed hotel queen who is on trial on federal tax-evasion charges.


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What do you think, guys? Is "y'all" in trouble?
For some time, "y'all" has been assaulted by "you guys" aiming to replace it as the go-to second-person-plural pronoun in the South. Is the Solid South still holding firm at the Mason-Dixon line, or is "you guys" infiltrating and spreading like kudzu, as it is elsewhere?
I wonder because I know some claim that it is. In the Dictionary of American Regional English, the usage note for "you guys" says "orig. chiefly North; now widespread; esp freq. am...
Across the street from the building that houses the linguists, philosophers, and computer scientists at my university (on the left in the picture above) is the city's huge central mosque. Hundreds of Muslims stream out of its doors after lunchtime prayers on Fridays to socialize in the courtyard. Men with men, of course (women have a separate exit door round the back).
A few yards away on the mosque side of the street is Maqbool's, a grocery store run by Pakistanis (I'll use that designation he...
¿Adónde van? Asked the bus-station clerk in the port city of Guayaquil, Ecuador, yesterday morning.
It's a reasonable question. Where am I going?
A few moments later from a rear seat I watch the dust and urban squalor along the River Guayas transition to miles of lush banana fields before we reach Puerto Inca, where the change really begins. After a left turn, the bus climbs 14,000 feet in an hour. In that ascent, languages and cultures transform like flora and fauna.
As we appr...
Wireliz Soto-González recently completed her master's in art history at the University of Barcelona. Jorge Fernández de Jesús received a master's in biology at the University of Navarra at Pamplona and is a teacher of English with the Council on International Educational Exchange. Both graduated from the University of Puerto Rico at Mayagüez.
What was it like studying at a Spanish university?
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I believe peak s-backing was reached on August 1, 2018. In a segment of NPR's All Things Considered that day, the host, Audie Cornish; the NPR correspondent she was speaking with, Ayesha Rascoe; and the news figure being discussed, Sarah Huckabee Sanders, all engaged in s-backing, which is a term for pronouncing the s in a word as if it were sh. It's called s-backing because you move your tongue toward the back of your mouth in order to do it. Some linguists refer to the phenomenon as "retracted...
There was breaking news about foreign languages last Thursday afternoon: Chinese has now overtaken German in popularity as a subject among high-school seniors in England. (I would bet the same holds for California, but I don't have the figures.) At "A-level" — the key determinant of eligibility for college, roughly like a U.S. high-school diploma — 3,334 students took Chinese this year (up 8.6 percent on last year...
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I have a distinguished colleague who unceasingly tries to persuade me to see that my attempts at descriptive grammar really have a prescriptive subtext. We were both participants in a workshop on the history and philosophy of linguistics last week, and the dispute reared its ugly head again.
Being a descriptive linguist has nothing to do with the crazy notion that "anything goes" or the absurd idea th...
If you really want to know how people use the English language in North America, you will find one consistently reliable peer-reviewed source of information, four times a year: the journal American Speech, sponsored by the American Dialect Society and published by Duke University Press.
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Donald Trump has a unique way of speaking and writing. But for a president his language is not unprecedented. Or not unpresidented.
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Observation Deck of Sydney Tower
From the golden beaches to the distant Blue Mountains, Sydney Tower takes you to the highest point above Sydney Australia for breathtaking 360-degree views of our beautiful harbour city.Enjoy spectacular Sydney views, including the Sydney Harbour Bridge, Sydney Opera House and Sydney Harbour, with free telescopes and free guided tour on Observation Deck.
Plus your ticket to the top includes OzTrek, the largest simulated ride in Australia, that takes you on an amazing virtual reality adventure across Australias cultural history and geography.
Sydney Tower + OzTrek is the perfect place to start your Sydney holiday or Sydney vacation, as you can orientate yourself to the whole city before you commence your Sydney activities. Its also a great place for holiday activities, family fun activities, or simply a day out to be amazed by Sydneys best views!
Construction of Sydney Tower Centrepoint began in late 1970 with the first 52 shops opening in 1972. The office component was completed in 1974 and the final stage of the complex, the Sydney Tower, was opened to the public in August 1981.
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'Son of Saul' Review: From Holocaust Hell, Piercing Art
A Jewish worker in a Nazi death camp encounters the corpse of a boy he takes for his son
Good movies summon up worlds. "Son of Saul," a great movie and a debut feature by László Nemes, summons up a world we may think we know from a visual perspective we've never encountered—the willed tunnel vision of a Jewish worker in a Nazi death camp. This point of view is doubly protective. We're spared the worst of Auschwitz's horror because the protagonist, a Hungarian named Saul Ausländer (a phenomenal performance by Géza Röhrig), is determined to keep what's left of his sanity by focusing his gaze, and for a while his mind, on the ground in front of his feet and on whatever tasks may be at hand. His vision broadens...
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Quantitative LC-ESI-MS analyses of microcystins and nodularin-R in animal tissue--matrix effects and method validation.
@article{Karlsson2005QuantitativeLA, title={Quantitative LC-ESI-MS analyses of microcystins and nodularin-R in animal tissue--matrix effects and method validation.}, author={Krister M Karlsson and Lisa E. M. Spoof and Jussi Meriluoto}, journal={Environmental toxicology}, year={2005}, volume={20 3}, pages={381-9} }
- Published 2005 in Environmental toxicology
The matrix effects and signal response in LC-MS analysis of six microcystins and nodularin-R were studied in mussels and liver samples from the common eider and rainbow trout. The instrumentation used in the study was a triple quadrupole MS with electrospray ionization. The results from the spiked tissue samples showed that both signal suppression and enhancement occurred. The recorded matrix effects were not severe; all studied toxins could be detected with sufficient limit of detection in all… CONTINUE READING
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An integrated strategy for rapid and accurate determination of free and cell-bound microcystins and related peptides in natural blooms by liquid chromatography-electrospray-high resolution mass spectrometry and matrix-assisted laser desorption/ionization time-of-flight/time-of-flight mass spectromet
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As of 12/21, the former Encyclopedia Gamia has been redirected to this wiki, which is now the definitive wiki for this topic. To see more about this change, read more here.
|This article is a stub. You can help Codex Gamicus by expanding it.
|Basic Information
|Peripheral, Microconsole
|Sony Corporation
|PlayStation Portable
|Technical Information
|Japanese Release
January 23, 1999
|Awards | Covers | Credits | Help
Patches | Reviews | Screenshots | Videos
The PocketStation is microconsole created by Sony as a peripheral for the PlayStation. Released exclusively in Japan on December 23, 1998, it features an LCD screen, sound, a real-time clock, and infrared communication capability. It also serves as a standard PlayStation Memory Card.
Games for the PocketStation are stored on the same CD-ROM as certain PlayStation games. PocketStation games can enhance PlayStation games with added features. For example, using the PocketStation. a player may be able to 'level up' characters in one's favorite PlayStation game while riding the bus to work. A player can also download stand-alone PocketStation games. It allows a player to swap game data between PlayStation units and also allows multi-player gaming via the built-in infrared data link.
Although the system was not released in North America or Europe, there were apparently plans to do so - a feature on the system appeared in Official UK PlayStation Magazine, for example, and a few games (such as Final Fantasy VIII and SaGa Frontier 2) retained PocketStation functionality in their localised versions. As a result, the PC version of Final Fantasy VIII added a stand-alone Chocobo World minigame as part of the installation, which was also available on the Steam re-release.


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The third and last segment of "I May Be Bluffin'" was shot at a local hot spot in College Station, Texas and the music video is now in post-production, with a release date scheduled for September.
College Station, Texas (PRWEB) August 27, 2012
The Texas Poker Store's production of the music video, "I May Be Bluffin", with music and lyrics by Randy Pavlock and Chief Dealer, Jim Paris, and sung by Pavlock has now been completed. The video, produced and videographed by Kyle Netterville and directed by Netterville and Paris is now in post-production, with a release date set for September.
"We had a great time during the three shoots, including two in an amazing barn/man-cave out in Hearne, Texas, and the last one at a local nightspot in College Station, Texas. It was amazing how many friends came out to support us and be part of the video. Everyone who came to see the final table sequence got to be a "fan" of the players for the night," said Paris.
The final four players consisted of Paul "My House My Rules" Marvin, Troy "T-Licious" Davidson, Randy "The Real Deal" Pavlock and Jim "Chief Dealer" Paris with the dealer played by Gretchen Farrar. Whitney "Wildcat" Brandl, Hannah "Raisin Hell" Hasha, Camille "Cami" Butler, Allison "Alli" Glover, and Kelsey "Kel" Stanislaw were cast as the lovely young ladies who danced and rooted for their men. These beautiful models were provided by Hunter Artz of "Photos by Hunter Studios".
"Of course, we now have hours of editing to get through all the footage we shot before we can release "I May Be Bluffin'" to the world," Paris states. "The video tells an authentic poker story about a poker tourney that starts at a man-cave in the middle of the woods and finishes with the final poker table at a popular local club, so we know it will appeal to the millions of poker players out there. On the other hand, with Pavlock's gritty country-rock sound on the title song, along with those gorgeous young women, I believe it will also have universal appeal.
" I'm not going to tell you how it went at the final table heads-up showdown," Paris adds, "but I will say that the players splashed all their poker chips on the table . . . and someone walked away the big winner."
For the original version on PRWeb visit: http://www.prweb.com/releases/prweb2012/8/prweb9836876.htm


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Frequence Cafe Paris
Frequence Cafe Paris is free HD wallpaper. This wallpaper was upload at January 16, 2019 upload by admin in .You can download it in your computer by clicking resolution image in Download by size:. Don't forget to rate and comment if you interest with this wallpaper.
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WeatherTech In-Channel Side Window Deflectors - 80467
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WeatherTech In-Channel Side Window Deflectors Part #80467 Customer Reviews
5 Customer Reviews
Reviewed by Charles B (STRASBURG, VA) Reviewed for a 2008 Toyota Highlander — Jul 14, 2013 4:29 AM
Reviewed by Gerard V (Cloverdale, CA) Reviewed for a 2011 Nissan Rogue — Mar 15, 2012 10:17 AM
After installing and moving the window back up I noticed an audible window/deflector edge "clunk". Upon closer examination I dtermined that the upper window edge at the door(right) style side hit the edge of the deflector edge when the window closed. Even after 24 hours, this occurred. TC to WT id not resolve the matter except "return" advice. I removed the deflector and revied the edge and realised it was possibly too thick. I sanded the end ledge that goes into the the w.sill to make it thinmer and re-installed it. The "clunk" was much deminshed.I repeated the process on #2 My suggestion:to produce the deflector with a thinner edge on the rightsides only, to deminish this sound and make a better fit. Gerard


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I got to testdrive the new fireplace in the lake cottage from a kitty perspective. I approved.
Tuesday, 28 July 2015
4 comments:
dood...that fire place iz awesum !!! wunder how much fish it will cook !! ♥♥♥ReplyDelete
We agree, that fireplace is pawsome :)ReplyDelete
Purrs Georgia and Julie,
Treasure and JJ
Goodness Carlos, they sure make you work hard. We is glad it met your standards and that it wasn't fired up.ReplyDelete
Sasha, Sami, & Saku
What a nice fireplace!ReplyDelete
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if Virtualbox GUI use qt4 library, but arch/manjaro will install all qt4 bloat for you
it's not a bloat you pineapple, it's called a bloody dependency. Don;t blame arch/manjaro, every GNU and BSD system does this. Feel free to not install any qt applications.
"Dammit, Jim--I'm a pineapple, not a bloody dependency!"
sorry off topic. what does pineapple mean here?(I only know it is a kind of fruit)
i dunno pineapples have a prehistoric symbol of good will ... even illustrious http://www.cabinetmagazine.org/issues/23/beauman.phptheres always https://www.youtube.com/watch?v=-yhT9i7y0iM
i got an 8.5 GB system, and i don't even use gnome-shell. And i don't consider my system a bloated one. I have exactly what i need.Looks like someone is getting influenced by trolls on the webs. Bloat isn't always "disk usage" , or "number of packages", or "ram usage". Some idiots who can;t install a proper arch system tend to make fun of folks who install and use more packages than they do. Only way to shut them up is using a bare kernel with nothing but glibc and bash on top of it and howl "Look! No bloat!"The only things that, in all intent and purpose, bloat gnome-shell are 1. empathy+everything about telepathy (chat)2. tracker+online-miners (file indexing)Get rid of these and you can install 100 apps without any performance impact
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Breastfeeding and Menstruation
Your Period while Breastfeeding
Return of menstruation while breastfeeding
Many mothers think that if they are breastfeeding exclusively, their periods will not return. But the truth is that many mothers will soon start to menstruate - sometimes as early as a few weeks after birth.
Each woman is different and has varying levels of hormones. The period in which lactation suppresses your menstruation and fertility is called lactational amenorrhea.
Mothers may even find that with each pregnancy, they start menstruating at different times.
"I breastfed my son for nine months before my period started, but this time around my baby is only 11 weeks old and my period has started" by Tammy (Canada)
Delaying Menstruation
Can you keep your period away longer while breastfeeding?
- Breastfeed your baby on demand. The more you breastfeed, the longer your period should stay away. Nurse at least six times per day.
Breastfeed your baby at night, too. The main reason why most mothers will start their periods early is that they stop nursing at night. Nurse at least once at night.
Start your baby on solid foods only after six months.
Avoid the use of artificial nipples and pacifiers.
- Allow comfort nursing. Babywearing can also help.
Breastfeeding and Menstruation
What's Normal?
What's a normal period during breastfeeding?
Menstruation during breastfeeding can be very unpredictable.
- Most mothers experience some postpartum bleeding after birth, but this is not a mother's period.
Mothers who bottle feed their babies will usually start their periods within a month or two after giving birth.
Mothers who breastfeed may go without their period for weeks, months and even years while breastfeeding.
Some mothers may have no period while breastfeeding, and only start having their periods again after they have weaned their babies completely.
A mother may have irregular periods while breastfeeding and may skip some months. A missed period while breastfeeding is normal.
Moms may have premenstrual symptoms without any bleeding; this may be an indication that your period will be returning soon. It's best to start taking
precautions at this stage if you do not want to fall pregnant.
- Lactating mothers may notice some spotting.
A mother may find that her milk supply drops a little, just before a
period starts; this is due to hormonal fluctuations.
Some extra nipple tenderness is very common in breastfeeding mothers during a period, and this is also due to hormonal changes.
Some babies may drink more or less during a period, as milk might taste a little different.
- Mom may experience some uterine cramping during a period.
Breastfeeding and Menstruation
Getting Pregnant while Breastfeeding
Can you fall pregnant while breastfeeding, if your period has returned?
Yes, you should consider yourself fertile once your period has returned. It is also possible to become pregnant before your period returns, but this is a rare occurrence.
Breastfeeding and Menstruation
Coping with Period Pains
Symptoms during breastfeeding and menstruation
- A combination supplement of 1500 calcium/400 magnesium per day (always taken together, never separately); this will regulate your periods, prevent nipple tenderness, keep milk supply up and also prevent uterine cramping.
- Evening primrose (1 per day) can be taken to relieve nipple tenderness.
One Mom's Personal Experience
Featured Comments
Help, irregular periods and breastfeeding!
"Hello, my baby is almost 15 months old, and we are still breastfeeding.
My period has been coming pretty regularly since my daughter turned about 5/6 months old, but they were always late.
Last month I had a normal period, but this month I haven't started at all? I am worried about pregnancy because I don't want another baby this soon.
My husband and I do use protection when we "get" to have sex. Is it normal to be this late during breastfeeding?
My daughter still breastfeeds on demand, but she, of course, eats solid foods too. She also nurses throughout the night since she sleeps with me, she nurses most of the night."
Re: Help, irregular periods and breastfeeding!
by: Tracy
Yes, it is normal during breastfeeding to have irregular periods.
Your hormones are always changing, according to the time your child spends on the breast. The more you breastfeed, the less likely you are to get a period. But this is not the case with everyone, we all have different hormone levels; a mother may have regular periods, even if she skips feeds regularly, or combination feeds."
Irregular Periods.
by Karen LaRose
"My last period was 25th, November, however around December, 18, last I began having premenstrual symptoms, but I am still waiting for a period.
In addition to waiting in expectation, I am experiencing at times severe cramping in my right side, but this usually lasts for a few minutes and would subside, its also irregular, sometimes a day or two would pass and no cramps at all.
I refused to take a home pregnancy test because I keep getting premenstrual symptoms and believe my period would come at any moment. Both before and after my son was born, I have experienced irregular periods, but once I began to get cramps, it would usually come shortly.
I am concerned about this because I don't know if its normal what I am experiencing, because I am still breastfeeding my 28-month-old."
Re: Irregular Periods.
by: Tracy
"Hi Karen, Any irregularity is normal during breastfeeding, the pains that you are experiencing could be hormone related.
I am breastfeeding my 18-month-old and still skip months in which I also experience some cramps, but no bleeding.
If the pain is severe, it's best to see your doctor. Those pains can also be an early sign of pregnancy.
Hope this helps."
Leave an anonymous comment
Your comment...
What Other Moms Have Said
Click below to see contributions from other visitors to this page...
Period Stops
I started having my period 5weeks postpartum, but it stopped when my baby turned five months. She's 7and a half months now, and I still haven't seen my …
I'm worried. have i got reason to be?
I'm still feeding my 18-month-old on demand around three times during a day and 3/4 at night. I got back my period when my baby was ten month. they were …
Fertility while breastfeeding
I'm weaning my son in a week, he will be completely off and be on 100 bottle. I use to have normal periods, but since his birth only had two periods. …
is it normal to miss a period
I'm a lactating mother, and I have a period for two months and missed period this month, and my pregnancy test is negative on the first day of my missed …
Periods breastfeeding
My baby is 15 months old now and is still Brest fed. I started my period last month, and it was very short(1.5 days). I am now on my second period, …
no period breastfeeding
I am breastfeeding and giving my 3month old formula and still haven't got my period. But I 've had cramp for the last three days, and my partner and I …
periods while breastfeeding
I gave birth to my daughter six weeks ago. I had a c-section so i stopped bleeding around 3 weeks ago. I am currently breastfeeding and wanted to know …
Am I pregnant?
Please I'm breastfeeding my baby for five months plus baby foods too just last month I had my first period since giving birth and this month I didn't not …
missed period breastfeeding
I have an 8 month who I breastfeed exclusively, including a few feedings at night, and has also started eating solids. Four months after she was born …
normal periods and breastfeeding
I am breastfeeding, and I want to have my menstruation, what drug can I take?


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We couldn't find a pet by that name. Is it spelled correctly?
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Make lists of the items you own and want, and share them with the world.
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Teaching Trig: a summary of my ex-department's approach to the subject, with a special emphasis on the initial introduction of these concepts.
Asilomar Notes: Story Tables: A session where I learned about a phenomenally powerful tool to teach about functions.
Asilomar Notes: Tech: Two interesting sessions involving the use of technology in the teaching of math. Read my notes and reactions.
Updates to my Math Education Page
Spirograph Simulation: For some reason, while the online applet worked, the GeoGebra file I included did not open when downloaded. I got some help on Twitter, and posted a corrected version.
Résumé: updated.
Errata: I added a bunch of downloadable corrected pages to the Lab Gear books Errata page.
All Math Education Page Updates
What else is new
14 January 2019: I restored five posts about the geoboard: Geoboard Triangles, No Three on a Line, Heilbronn's Triangle, Ariadne's String, and Geoboard Problems for Teachers.
9 January 2019: I will offer a grades 6-9 version of my workshop on Visual Algebra twice this summer: June 25-27 at Synapse School in Silicon Valley, and again August 7-9 at Atrium School in Boston. I will post more information here as it becomes available.
9 January 2019: I restored the graphics in two posts: "A New Algebra" where I bragged about Robert Davis's praise for my approach; and Geoboards and Dot Paper, where I introduced subsequent posts on using these tools as a microworld for problem solving, and bragged about having invented the "tilted squares" intro to the Pythagorean theorem decades ago.
27 November 2018: I moved my blog into WordPress (here.) I thought the move had happened smoothly, but some graphics, and some entire posts, failed to materialize. Also, many links are broken. If you come across these problems, please notify me, indicating which post had the issue. Thanks!
Henri Picciotto
I have retired from the classroom after 42 years as a math teacher in K-12 — from counting to calculus. I now work with teachers and schools:
Math Education Consulting
I share instructional materials on my Math Education Page, and my views on math education on this blog.
On this page: announcements about new material, updates, etc. on the site; new publications; my appearances at conferences; and my other activities in math education.
Note: All material on this site is copyrighted. You may reproduce it for any non-commercial purpose, as long as you credit me and link to the blog. More info.
(I am also involved in word puzzles, especially cryptic crosswords.
More on this.)


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text:
|List |< first << previous [record 52 of 74] next >> last >|
|Mutation Type
|critical splice donor site (2 bp from exon)
|60,520,914 bp (GRCm38)
|Base Change
|T ⇒ C (forward strand)
|Gene Name
|myosin XV
|sh2; sh-2; Myo15a
|Chromosomal Location
|60,469,339-60,528,369 bp (+)
|MGI Phenotype
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an unconventional myosin. This protein differs from other myosins in that it has a long N-terminal extension preceding the conserved motor domain. Studies in mice suggest that this protein is necessary for actin organization in the hair cells of the cochlea. Mutations in this gene have been associated with profound, congenital, neurosensory, nonsyndromal deafness. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Read-through transcripts containing an upstream gene and this gene have been identified, but they are not thought to encode a fusion protein. Several alternatively spliced transcript variants have been described, but their full length sequences have not been determined. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mutations in this gene result in profound deafness and neurological behavior. [provided by MGI curators]
|Accession Number
NCBI RefSeq: NM_010862, NM_182698, NM_001103171; MGI:1261811
|Amino Acid Change
|Institutional Source
|Beutler Lab
|Gene Model
|predicted gene model for protein(s): [ENSMUSP00000071777] [ENSMUSP00000080507] [ENSMUSP00000091686]
|SMART Domains
Protein: ENSMUSP00000071777
Gene: ENSMUSG00000042678
|Predicted Effect
|probably null
|SMART Domains
Protein: ENSMUSP00000080507
Gene: ENSMUSG00000042678
|Predicted Effect
|probably null
|SMART Domains
Protein: ENSMUSP00000091686
Gene: ENSMUSG00000042678
|Predicted Effect
|probably null
|Phenotypic Category
|Alleles Listed at MGI
All alleles(7) : Targeted(3) Spontaneous(2) Chemically induced(1) Radiation induced(1)
|Lab Alleles
|Mode of Inheritance
|Autosomal Recessive
|Local Stock
|Live Mice
|MMRRC Submission
|Last Updated
|2017-03-02 9:36 AM by Katherine Timer
|Record Created
|2013-07-01 9:29 AM by Jennifer Weatherly
|Record Posted
|Phenotypic Description
The parker phenotype was initially identified among G3 mice of the pedigree R0477, some of which displayed constant movement of the head from side-to-side, head tilt, circling behavior, and wobbling (Figure 1).
|Nature of Mutation
Whole exome HiSeq sequencing of the G1 grandsire identified 56 mutations. The vesitbular phenotype was linked to a mutation in Myo15: a T to C transition at 60,520,914 on chromosome 11, corresponding to base pair 51,576 in GenBank genomic region NC_000077. Linkage was found with a recessive model of inheritance (P = 4.307 x 10-5), wherein 6 variant homozygotes departed phenotypically from 46 unaffected mice that were either homozygous variant (n = 9), heterozygous (n = 19), or homozygous for the reference allele (n = 18) (Figure 2). Myo15 encodes several isoforms including a long isoform (NM_182698; isoform 1; contains 66 total exons) and two others that lack in-frame exons in the 5' coding region (isoform 2a (NM_182698; contains 64 total exons) and isoform 3 (NM_001103171; contains 65 total exons); see "Protein Prediction" for more details. The mutation is located in the donor splice site of intron 61 in isoform 1, intron 59 in isoform 2a, and intron 60 in isoform 3, two nucleotides from the previous exon in each transcript. The effect of the mutation at the cDNA and protein level of each isoform is unknown. One possibility, shown below, is that aberrant splicing may result in the skipping of the 161 base pair preceding exon (exon 61 in isoform 1 (shown); alternatively, exon 59 in isoform 2a and exon 60 in isoform 3) and splicing from exon 60 to exon 62 in isoform 1 (alternatively, splicing from exon 58 to exon 60 in isoform 2a or splicing from exon 59 to exon 61 in isoform 3). The aberrant splicing would lead to a deletion of 53 amino acids (amino acids 3244-3297) as well as a frameshift and subsequent coding of a premature stop codon.
<--exon 60 <--exon 61--> intron 61--> exon 62-->
49134 ……GTCACCAACCGAG GCCAGCACGTGTGT……ATGCACTACAATCAG gtcagagatg………GTTCTGCCTGA
correct deleted aberrant
Genomic numbering corresponds to NC_000077. Isoform 1 is shown. The donor splice site of intron 61 of Myo15, which is destroyed by the mutation, is indicated in blue; the mutated nucleotide is indicated in red.
|Protein Prediction
Myosins are divided into conventional (muscle myosins and myosins similar in structure and function to muscle myosins, all belonging to class II) and unconventional classes (myosins that do not resemble muscle myosins). Myo15 encodes myosin XV (alternatively, Myosin XVa), a 3,511 amino acid member of the unconventional myosin family.
Myosin XV has a proline-rich N-terminal extension [Figure 3; amino acids 1-1200; SMART; (2;3)]. The N-terminal extension is encoded by exon 2 does not have sequence similarity to reported proteins and the function is unknown (2;4). Mouse Myo15 encodes transcript variants: isoform 1 encodes the full-length class 1 myosin XV protein, isoform 2a encodes a myosin XV protein without exon 2 and exon 26, and isoform 3 encodes a myosin XV protein without exon 2; all three isoforms are functional. Analysis of inner ear human MYO15 cDNAs determined that there are also several alternatively spliced MYO15 transcripts in human (3). The MYO15 cDNAs were individually missing exons 2, 8, 26, 30, 40, and 61 (3). Skipping of exons 30, 40, or 61 resulted in a frameshift that terminated the open reading frame shortly downstream of the missing exon (3). Skipping of exons 2, 8, or 26 did not interrupt the MYO15 reading frame (3). Exon 2 encodes the myosin XV start codon and encodes most of the 1223 amino acid N-terminal extension (3). The first start codon in-frame in the transcripts without exon 2 is located at the beginning of exon 3, coding 20 amino acids preceding the motor domain (3). Exon 8 encodes two amino acids in the motor domain, while exon 26 encodes an 18-amino acid insertion in the second IQ motif; a stop codon is introduced into the open reading frame in the long form of exon 26, resulting in truncation of the myosin XV protein after the IQ motifs (3).
Myosin XV has a highly conserved motor domain (amino acids 1200-1884; NM_010862; SMART) following the N-terminal extension (3). The motor domain contains an adenosine triphosphate (ATP)- and an actin-binding site (amino acids 1299-1306 and 1776-1783, respectively; Uniprot) (5-7). The motor domain in Nina C, a myosin expressed in the photoreceptor cells of Drosophila retinas, was necessary to maintain the structure of the photoreceptor cells (2). Missense mutations within the motor domain of myosin XV (e.g., C1779Y or R1354A;G1575A; NM_010862) resulted in mislocalization of myosin XV in the bodies of transfected wild-type auditory hair cells; the mutants were unable to properly target to the tips of the stereocilia (8).
The myosin neck region contains a variable number of light-chain binding (IQ) motifs (IQxxxRGxxxRK) and is linked to the motor domain by a converter region [(9); reviewed in (10;11)]. Myosin XV has two IQ motifs (1909-1920; LQRCLRGFFIKR and 1932-1943; LQSRARGYLARQ) (2;3;6). The IQ motif is an α-helical structure that often mediates the binding of myosins to calmodulin, members of the EF-hand family of calcium-binding proteins, or myosin light chains [reviewed in (10;11)].
The tail regions of the myosins are divergent in length and sequence (6). The myosin XV tail is 1584 amino acids in length and has two myosin tail homology 4 (MyTH4) domains (amino acids 2049-2195 and 3031-3185; SMART), a band 4.1/ezrin/radixin/moesin (FERM)-like domain (amino acids 2687-2867, human myosin XVa), a Src homology 3 (SH3) domain (amino acids 2851-2933), and a FERM domain (alternatively, talin-like domain; amino acids 3188-3400) (2;3;12;13). MyTH4 domains have an unknown function, but are found in the tails of other myosins, including myosins IV, VIIA, X, and XII as well as kinesin-like motor proteins (3;12). The MyTH4 domain is proposed to function in microtubule binding as well as in actin binding to the plasma membrane (14). FERM domains are often found in membrane-associated proteins and mediate the interaction of the FERM-containing proteins with the cytoplasmic domains of integral membrane proteins and/or they function as a mediator between the cell membrane and actin cytoskeleton (12;15;16). The FERM domain of myosin XV is proposed to be involved in anchoring myosin XV to the cell membrane (2). SH3 domains function in recognizing and binding proline-rich sequences (17). SH3 domains are often found in proteins that function in synaptic vesicle endocytosis (18) and in the proper localization of proteins (19). The function of the myosin XV SH3 domain is unknown, but it is proposed to mediate an intramolecular interaction with a region in the proline-rich N-terminal extension to regulate the activity of myosin XV (3).
Myosin XV is unique among the myosins in that it has a predicted class I PDZ-ligand motif (ITLL*) at the C-terminus (8;13;20). The PDZ-ligand motif of myosin XV is required for association of myosin XV with whirlin as well as the localization of whirlin to stereocilia tips (described in "Background", below) (8;21).
The parker mutation is predicted to result in a loss of exon 61 (isoform 1) encoding amino acids 3244-3297. In each of the isoforms, the parker mutation is predicted to result in the loss of a portion of the C-terminal FERM domain and the subsequent coding of a premature stop codon within that domain.
Myo15 is expressed as early as embryonic day (E) 13.5 in the developing mouse inner ear (2). At E15.5, Myo15 transcripts are expressed in the cristae ampularis, macula utriculi, and macula sacculi, and cochlea in the ear (2;3). At E18.5, Myo15 is restricted to the sensory epithelium of the organ of Corti in the cochlea (2;21). At postnatal day (P) 8, Myo15 is expressed in the inner hair cells and outer hair cells of the organ of Corti within the inner ear (2). In the adult mouse, Myo15 is also expressed in the brain and liver (5).
At P7 onward, myosin XV is localized to the capping region (i.e., the location of the growth and remodeling of the actin core) of the stereocilium in the inner ear hair cells, between the upper end of the actin core and apical plasma membrane (22-24). The amount of myosin XV is directly proportional to the length of the stereocilia (13;23;24). Myosin XV continuously migrates towards the plus ends of actin filaments and accumulates at the stereocilia tips (8;21).
Expression analysis of MYO15A in human tissues has been conflicting. Wang et al. determined that MYO15A is expressed in the cochlea of 18- to 22-week fetuses as well as in human fetal and adult brain, ovary, testis, kidney, and pituitary gland (6). Liang et al. determined that MYO15 was predominantly expressed in the adult pituitary gland, with less expression in the testis and ovary; low expression (compared to the expression level in the pituitary gland) was detected in the adult human brain, kidney, liver, lung, pancreas, placenta, or skeletal muscle (3). The discrepancies between the expression analysis in the Liang et al. study compared to that of Wang et al. was attributed to the design of the probe used in the Northern blot analysis (3). Additional studies determined that myosin XV mRNA and protein are expressed in all types of normal anterior pituitary cells and pituitary tumors, several cells of all endocrine tumors of the gut and pancreas, normal endocrine cells of the small bowel, gastric, adrenal medulla, paraganglionic tissue as well as in most pancreatic islet cells (25;26). Expression was variable in pituitary cells; the most intense staining was observed in the secretory granules of adrenocorticotropic hormone, prolactin, and glycoprotein hormone-producing cells (26).
Myosins are actin-based molecular motors that generate mechanical force using the energy generated from the hydrolysis of adenosine triphosphate (ATP) (3;6). Myosins function in organelle and vesicle movement, cytokinesis, phagocytosis, signal transduction, cellular movement, membrane trafficking, regulation of ion channels, and muscle contraction (5;27;28). For more information about the general functions of myosins see mayday circler (Myo6) and new gray (Myo5a).
Each hair cell in the inner ear is comprised of a bundle of up to 300 stereocilia that project from the apical cell surface (13;29); each stereocilium is filled with up to 1000 polarized and cross-linked actin filaments [Figure 4; (22)]. The stereocilia are organized in a staircase pattern and held together by extracellular lateral projections (side-links). Deflection of the hair bundle results in gating of transducer channels at the tips of the stereocilia and subsequent modulation of the cell membrane potential that converts the sound-evoked mechanical stimulus into an electrical signal (i.e., mechano-electrical transduction) (29;30). For more information about proteins involved in the maintenance and function of the hair cells of the inner ear please see the records for dee dee and squirm. Myosin XI (see mayday circler) also functions in the development and/or maintenance of sensory hair cells; the function of myosin XV and myosin XI do not overlap (9). Myosin XV functions in the assembly and maintenance of actin organization in hair cells of the inner ear by acting as a motor and carrier along the length of the actin filament within the hair cells (31). Myosin XV senses the tension between the plasma membrane and the actin filaments, a function that is necessary in the growth of the steocilia (13). Myosin XV contributes to the elongation of stereocilia by delivering whirlin, a multi-PDZ domain-containing scaffold protein, to the stereocilia tips (8). Both myosin XV and whirlin are required for the elongation and staircase formation of the stereocilia bundle and myosin XV and whirlin may function as part of a complex that modulates the growth of actin bundles in the stereocilia (8;13). Another proposed function of myosin XV is the maintenance of the hair cell mechanotransduction apparatus at the tips of the stereocilia (5;8). The function of myosin XV in endocrine cells is unknown. Within pituitary cells and pituitary adenomas, myosin XV may function in cytoplasmic organelle movement, including secretory granules and/or hormone secretion (25).
Two myosin XV mutant mouse models, shaker 2 (Myo15sh2; MGI:1857036) and shaker 2J (Myo15sh2J; MGI:1889795) have been characterized. The Myo15sh2 mutation is a tyrosine to cysteine substitution at amino acid 1779 within the myosin motor domain (5;7). The spontaneous Myo15sh2J mutation results in the deletion of the last six exons and part of the 3' flanking region encoding the myosin XV C-terminus, including the C-terminal FERM domain (2). Both the shaker 2 and shaker 2J mice have abnormally short stereocilia bundles on the inner ear hair cells compared to wild-type mice; the bundles are correctly positioned (2;5). As a result, the shaker 2 and shaker 2J homozygous mice are congenitally deaf and exhibit vestibular defects that cause head-tossing and circling behavior (3-5). The mechanosensory activity of the short stereocilia in young shaker 2 mice are not affected despite the changes in stereocilia length (32). Further studies determined that the Myo15sh2 mutation disrupts fast adaptation and calcium sensitivity in cochlear inner hair cells (33). In the inner hair cells of young (up to P14) shaker 2 mice, the mechanosensitivity is mediated by "top-to-top" links that run perpendicular to the shortened stereocilia; the outer hair cells have a prominent staircase stereocilia arrangement and obliquely-oriented tip links (32;33). Lack of myosin XV expression allows myosin VIIa molecules to localize between the plasma membrane and actin bundle in the short stereocilia of the shaker 2 mice; no myosin XV was detected at the tips of inner ear hair cell stereocilia (22). Transfection of a green fluorescent protein (GFP)-Myo15 into shaker 2 sensory epithelial explants resulted in complete rescue of the normal length and shape of the hair bundles by 67 hours post-transfection (8). In addition, a bacterial artificial chromosome (BAC)-mediated transgene corrected the deafness and circling phenotype of shaker 2 mice and the hair cells had normal stereocilia and no unusual actin-containing structures (5). A spontaneous mutant rat model, LEW/Ztm-ci2, exhibits syndromal deafness as well as spontaneous lateralized circling behavior, locomotor hyperactivity, moderate ataxia and the inability to swim (31). The ci2 model has a leucine to proline substitution at amino acid 3157 in the myosin XV protein within the C-terminal MyTH4 domain (31). In this model, the organ of Corti was completely absent or reduced (31). The inner hair cells of the vestibular organs were present, but there was shortened stereocilia, a lower number of ganglion cells, and a reduced thickness of axons (31).
As of 2009, 24 mutations in MYO15A have been linked to autosomal recessive nonsyndromic congenital deafness [(DFNB3; OMIM: #600316); (4;6;21)]; nonsyndromic recessive deafness accounts for ~80% of hereditary hearing loss (6).
|Putative Mechanism
The Myo15parker mutation is predicted to be similar to the Myo15sh2J mutation; both mutations affect the C-terminal FERM domain and result in the deletion of the last six exons of Myo15 (2). Similar to the shaker 2J mice, the parker mice exhibit head-tossing and circling behavior. Anderson et al. propose that the myosin XVshaker 2J protein is unable to exert force on the actin cytoskeleton because the truncated protein is improperly anchored, resulting in a failure to form the scaffolding to form the normal stereocilia structure (2).
PCR Primer
parker(F):5'- GCATGTGGCTTAGACCACAGTGTTC -3'
parker(R):5'- GCACACTATCAGGCTATGCAGAGG -3'
Sequencing Primer
parker_seq(F):5'- AGACCACAGTGTTCCTTCTTC -3'
parker_seq(R):5'- agctggcctggagcttg -3'
Parker genotyping is performed by amplifying the region containing the mutation using PCR, followed by sequencing of the amplified region to detect the single nucleotide transition.
PCR Primers
Parker(F): 5'- GCATGTGGCTTAGACCACAGTGTTC-3'
Parker(R): 5'- GCACACTATCAGGCTATGCAGAGG-3'
Sequencing Primer
Parker_seq(F): 5'- AGACCACAGTGTTCCTTCTTC-3'
PCR program
5) repeat steps (2-4) 40X
The following sequence of 533 nucleotides from GenBank genomic region NC_000077 encoding Myo15) is amplified:
51357 gcat
51361 gtggcttaga ccacagtgtt ccttcttcca gccgtgcctc tttctccctg caggccagca
51421 cgtgtgtcca ctgagctgcc gggcctacat actggatgtg gcctcagaga tggagcaggt
51481 ggacgggggc tacacactct ggttccggcg ggtgctttgg gatcagccac tgaagtttga
51541 gaatgagctg tatgtgacca tgcactacaa tcaggtcaga gatgcgacct ccctattgct
51601 ctgaacctac agtgccacgc ccagatgctt ggggaacttg taccaaagct ttagcaattc
51661 cacttacaaa acacaaccac gttgttggat gtggtaatgt atgccttgaa ttctagtgct
51721 caggaggcag aagcaggcag atctctgtga gttagaggcc agcctggtct acatagcaag
51781 ctccaggcca gctaaggcta tatagaaaga tcttttctga aacacacagc aacttcattc
51841 tgggaccaca tggtgttgag acctacctct gcatagcctg atagtgtgc
Primer binding sites are underlined and the sequencing primer is highlighted; the mutated nucleotide is shown in red text.
1. Suzuki, T., Li, W., Zhang, Q., Novak, E. K., Sviderskaya, E. V., Wilson, A., Bennett, D. C., Roe, B. A., Swank, R. T., and Spritz, R. A. (2001) The Gene Mutated in Cocoa Mice, Carrying a Defect of Organelle Biogenesis, is a Homologue of the Human Hermansky-Pudlak Syndrome-3 Gene. Genom. 78, 30-37.
2. Anderson, D. W., Probst, F. J., Belyantseva, I. A., Fridell, R. A., Beyer, L., Martin, D. M., Wu, D., Kachar, B., Friedman, T. B., Raphael, Y., and Camper, S. A. (2000) The Motor and Tail Regions of Myosin XV are Critical for Normal Structure and Function of Auditory and Vestibular Hair Cells. Hum Mol Genet. 9, 1729-1738.
3. Liang, Y., Wang, A., Belyantseva, I. A., Anderson, D. W., Probst, F. J., Barber, T. D., Miller, W., Touchman, J. W., Jin, L., Sullivan, S. L., Sellers, J. R., Camper, S. A., Lloyd, R. V., Kachar, B., Friedman, T. B., and Fridell, R. A. (1999) Characterization of the Human and Mouse Unconventional Myosin XV Genes Responsible for Hereditary Deafness DFNB3 and Shaker 2. Genomics. 61, 243-258.
4. Nal, N., Ahmed, Z. M., Erkal, E., Alper, O. M., Luleci, G., Dinc, O., Waryah, A. M., Ain, Q., Tasneem, S., Husnain, T., Chattaraj, P., Riazuddin, S., Boger, E., Ghosh, M., Kabra, M., Riazuddin, S., Morell, R. J., and Friedman, T. B. (2007) Mutational Spectrum of MYO15A: The Large N-Terminal Extension of Myosin XVA is Required for Hearing. Hum Mutat. 28, 1014-1019.
5. Probst, F. J., Fridell, R. A., Raphael, Y., Saunders, T. L., Wang, A., Liang, Y., Morell, R. J., Touchman, J. W., Lyons, R. H., Noben-Trauth, K., Friedman, T. B., and Camper, S. A. (1998) Correction of Deafness in Shaker-2 Mice by an Unconventional Myosin in a BAC Transgene. Science. 280, 1444-1447.
6. Wang, A., Liang, Y., Fridell, R. A., Probst, F. J., Wilcox, E. R., Touchman, J. W., Morton, C. C., Morell, R. J., Noben-Trauth, K., Camper, S. A., and Friedman, T. B. (1998) Association of Unconventional Myosin MYO15 Mutations with Human Nonsyndromic Deafness DFNB3. Science. 280, 1447-1451.
7. Cope, M. J., Whisstock, J., Rayment, I., and Kendrick-Jones, J. (1996) Conservation within the Myosin Motor Domain: Implications for Structure and Function. Structure. 4, 969-987.
8. Belyantseva, I. A., Boger, E. T., Naz, S., Frolenkov, G. I., Sellers, J. R., Ahmed, Z. M., Griffith, A. J., and Friedman, T. B. (2005) Myosin-XVa is Required for Tip Localization of Whirlin and Differential Elongation of Hair-Cell Stereocilia. Nat Cell Biol. 7, 148-156.
9. Karolyi, I. J., Probst, F. J., Beyer, L., Odeh, H., Dootz, G., Cha, K. B., Martin, D. M., Avraham, K. B., Kohrman, D., Dolan, D. F., Raphael, Y., and Camper, S. A. (2003) Myo15 Function is Distinct from Myo6, Myo7a and Pirouette Genes in Development of Cochlear Stereocilia. Hum Mol Genet. 12, 2797-2805.
10. Friedman, T. B., Sellers, J. R., and Avraham, K. B. (1999) Unconventional Myosins and the Genetics of Hearing Loss. Am J Med Genet. 89, 147-157.
11. Mooseker, M. S., and Cheney, R. E. (1995) Unconventional Myosins. Annu Rev Cell Dev Biol. 11, 633-675.
12. Chen, Z. Y., Hasson, T., Kelley, P. M., Schwender, B. J., Schwartz, M. F., Ramakrishnan, M., Kimberling, W. J., Mooseker, M. S., and Corey, D. P. (1996) Molecular Cloning and Domain Structure of Human Myosin-VIIa, the Gene Product Defective in Usher Syndrome 1B. Genomics. 36, 440-448.
13. Delprat, B., Michel, V., Goodyear, R., Yamasaki, Y., Michalski, N., El-Amraoui, A., Perfettini, I., Legrain, P., Richardson, G., Hardelin, J. P., and Petit, C. (2005) Myosin XVa and Whirlin, Two Deafness Gene Products Required for Hair Bundle Growth, are Located at the Stereocilia Tips and Interact Directly. Hum Mol Genet. 14, 401-410.
14. Weber, K. L., Sokac, A. M., Berg, J. S., Cheney, R. E., and Bement, W. M. (2004) A Microtubule-Binding Myosin Required for Nuclear Anchoring and Spindle Assembly. Nature. 431, 325-329.
15. Yonemura, S., Hirao, M., Doi, Y., Takahashi, N., Kondo, T., Tsukita, S., and Tsukita, S. (1998) Ezrin/radixin/moesin (ERM) Proteins Bind to a Positively Charged Amino Acid Cluster in the Juxta-Membrane Cytoplasmic Domain of CD44, CD43, and ICAM-2. J Cell Biol. 140, 885-895.
16. Chishti, A. H., Kim, A. C., Marfatia, S. M., Lutchman, M., Hanspal, M., Jindal, H., Liu, S. C., Low, P. S., Rouleau, G. A., Mohandas, N., Chasis, J. A., Conboy, J. G., Gascard, P., Takakuwa, Y., Huang, S. C., Benz, E. J.,Jr, Bretscher, A., Fehon, R. G., Gusella, J. F., Ramesh, V., Solomon, F., Marchesi, V. T., Tsukita, S., Tsukita, S., and Hoover, K. B. (1998) The FERM Domain: A Unique Module Involved in the Linkage of Cytoplasmic Proteins to the Membrane. Trends Biochem Sci. 23, 281-282.
17. Yu, H., Chen, J. K., Feng, S., Dalgarno, D. C., Brauer, A. W., and Schreiber, S. L. (1994) Structural Basis for the Binding of Proline-Rich Peptides to SH3 Domains. Cell. 76, 933-945.
18. Shupliakov, O., Low, P., Grabs, D., Gad, H., Chen, H., David, C., Takei, K., De Camilli, P., and Brodin, L. (1997) Synaptic Vesicle Endocytosis Impaired by Disruption of Dynamin-SH3 Domain Interactions. Science. 276, 259-263.
19. Anderson, B. L., Boldogh, I., Evangelista, M., Boone, C., Greene, L. A., and Pon, L. A. (1998) The Src Homology Domain 3 (SH3) of a Yeast Type I Myosin, Myo5p, Binds to Verprolin and is Required for Targeting to Sites of Actin Polarization. J Cell Biol. 141, 1357-1370.
20. Sheng, M., and Sala, C. (2001) PDZ Domains and the Organization of Supramolecular Complexes. Annu Rev Neurosci. 24, 1-29.
21. Shearer, A. E., Hildebrand, M. S., Webster, J. A., Kahrizi, K., Meyer, N. C., Jalalvand, K., Arzhanginy, S., Kimberling, W. J., Stephan, D., Bahlo, M., Smith, R. J., and Najmabadi, H. (2009) Mutations in the First MyTH4 Domain of MYO15A are a Common Cause of DFNB3 Hearing Loss. Laryngoscope. 119, 727-733.
22. Prosser, H. M., Rzadzinska, A. K., Steel, K. P., and Bradley, A. (2008) Mosaic Complementation Demonstrates a Regulatory Role for Myosin VIIa in Actin Dynamics of Stereocilia. Mol Cell Biol. 28, 1702-1712.
23. Belyantseva, I. A., Boger, E. T., and Friedman, T. B. (2003) Myosin XVa Localizes to the Tips of Inner Ear Sensory Cell Stereocilia and is Essential for Staircase Formation of the Hair Bundle. Proc Natl Acad Sci U S A. 100, 13958-13963.
24. Rzadzinska, A. K., Schneider, M. E., Davies, C., Riordan, G. P., and Kachar, B. (2004) An Actin Molecular Treadmill and Myosins Maintain Stereocilia Functional Architecture and Self-Renewal. J Cell Biol. 164, 887-897.
25. La Rosa, S., Capella, C., and Lloyd, R. V. (2002) Localization of Myosin XVA in Endocrine Tumors of Gut and Pancreas. Endocr Pathol. 13, 29-37.
26. Lloyd, R. V., Vidal, S., Jin, L., Zhang, S., Kovacs, K., Horvath, E., Scheithauer, B. W., Boger, E. T., Fridell, R. A., and Friedman, T. B. (2001) Myosin XVA Expression in the Pituitary and in Other Neuroendocrine Tissues and Tumors. Am J Pathol. 159, 1375-1382.
27. Mermall, V., Post, P. L., and Mooseker, M. S. (1998) Unconventional Myosins in Cell Movement, Membrane Traffic, and Signal Transduction. Science. 279, 527-533.
28. Baker, J. P., and Titus, M. A. (1997) A Family of Unconventional Myosins from the Nematode Caenorhabditis Elegans. J Mol Biol. 272, 523-535.
29. Etournay, R., Lepelletier, L., Boutet de Monvel, J., Michel, V., Cayet, N., Leibovici, M., Weil, D., Foucher, I., Hardelin, J. P., and Petit, C. (2010) Cochlear Outer Hair Cells Undergo an Apical Circumference Remodeling Constrained by the Hair Bundle Shape. Development. 137, 1373-1383.
30. Fettiplace, R., and Hackney, C. M. (2006) The Sensory and Motor Roles of Auditory Hair Cells. Nat Rev Neurosci. 7, 19-29.
31. Held, N., Smits, B. M., Gockeln, R., Schubert, S., Nave, H., Northrup, E., Cuppen, E., Hedrich, H. J., and Wedekind, D. (2011) A Mutation in Myo15 Leads to Usher-Like Symptoms in LEW/Ztm-ci2 Rats. PLoS One. 6, e15669.
32. Stepanyan, R., Belyantseva, I. A., Griffith, A. J., Friedman, T. B., and Frolenkov, G. I. (2006) Auditory Mechanotransduction in the Absence of Functional Myosin-XVa. J Physiol. 576, 801-808.
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text:
gold medal 的德语 翻译
gold medal
Goldmedaille f
Copyright © by HarperCollins Publishers. All rights reserved.
包括 gold medal的例句
这些示例已被自动选择并可能包含敏感内容。 阅读更多…
Actually neither front-runner gets the gold medal.Times, Sunday Times (2010)
He steered them to a gold medal and disappeared.Times, Sunday Times (2008)
How can you guarantee two gold medals?The Sun (2011)
I know there are more potential gold medal winners out there.Times, Sunday Times (2016)
That's the thing about winning five gold medals: you can get away with wearing anything you like.Times, Sunday Times (2012)
The former Olympic gold medal winner 's joy was palpable.The Sun (2015)
Winning the gold medal couldn't have topped what I felt that night.Times, Sunday Times (2009)
And somewhere amid all that she will attempt to win her first Olympic gold medal after three silvers.Times, Sunday Times (2011)
The focus of attention will be on Cavendish to secure the home nation's first gold medal.Times, Sunday Times (2012)
But it's not just the star gold medal winners who are set to cash in.The Sun (2012)
I was the first Englishwoman for 84 years to win four gold medals.Times, Sunday Times (2016)
Nobody expected a gold medal in either race but both teams expected to be in the chase for one of the lesser medals.Times, Sunday Times (2008)
Then again, she had just won an Olympic gold medal.Times, Sunday Times (2008)
It would not take a gold medal to make it worthwhile.Times, Sunday Times (2016)
gold medal 的趋势
偶尔使用。在柯林斯辞典中, gold medal 是3万个最常用词之一。
gold medal 在其他语言中
英式英语: gold medal NOUN
A gold medal is a medal made of gold which is awarded as first prize in a contest or competition.
...her ambition to win a gold medal at the Winter Olympics.
- 美式英语: gold medal
- 巴西葡萄牙语: medalha de ouro
- 简体中文: 金牌
- 欧洲西班牙语: medalla de oro
- 法语: médaille d'or
- 德语: Goldmedaille
- 意大利语: medaglia d'oro
- 日语: 金メダル
- 韩语: 금메달
- 欧洲葡萄牙语: medalha de ouro
- 西班牙语: medalla de oro
与 gold medal相近的词
gold medal 的翻译—— 柯林斯 英语到德语
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Works photographic negative of cables between railway and foot bridges, Stretford
- Made:
- 1909-1919
- part of archive:
- Business records of W. T. Glover & Co. Ltd
Shows super tension cables passing from side of girder railway bridge to footbridge.
Related people
- Identifier:
- YA1972.36/MS0231/Neg 1493
- Subject:
- Electrical Engineering, Engineering, Photograph
- Access:
- Access is given in accordance with the Science and Industry Museum's access policy. Material from this collection is available to researchers through the Museum's Archive Study Area.
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Passive Income Ideas In Romania Fundamentals Explained
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Tone your arms at home with these simple exercises:
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Actor Nate Parker (Red Tails, The Secret Life Of Bees, The Great Debaters, Pride) is joining Casey Affleck, Rooney Mara, and Ben Foster in the cast for Ain't Them Bodies Saints. The indie film is written and directed by David Lowery (who was accepted to the Sundance Screenwriters Lab for the film) from the indieprod Parts And Labor. Producers are Amy Kaufman, James Johnston, Jay Van Hoy, Lars Knudsen, Toby Halbrooks.
'Red Tails' Nate Parker Cast In Indie 'Ain't Them Bodies Saints'
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Heal Flow Acupuncture
Project Details
For Danielle of Heal flow Acupuncture I did several projects.
The first was the vectorization of her logo. I was provided a painting of the logo typeface and symbol and asked to convert it to a vectorized file.
The second was the creation of a small, simple website to showcase her business and services as well as a platform to link clients to her online booking system. The site was created with the WordPress theme Enfold.


text:
LONDON (MarketWatch) -- Herbalife Ltd. HLF, -0.47% said on Monday it plans to offer $1 billion of convertible notes and use the proceeds to buy back shares. The company said the initial buyers of the notes will be Bank of America Merrill Lynch BAC, -0.72% Credit Suisse Group AG CSGN, -0.12% HSBC Holdings PLC HSBA, -0.61% HSBC, -1.29% 0005, -0.23% and Morgan Stanley MS, -2.93% In January, Sen. Edward Markey, a Democrat from Massachusetts, called for an investigation into the company's business model, suggesting that Herbalife may be a "possible pyramid scheme." The stock dropped 18% last month, but was up 1.4% premarket on Monday.
Have breaking news sent to your inbox. Subscribe to MarketWatch's free Bulletin emails. Sign up here.


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|Richard Donat
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|Thomas Haden Church
|Isaac Andrews
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|Yuvika Chaudhary
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|Scott Foley
|Noell Coet
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There either is or is not, that's the way things are. The colour of the day. The way it felt to be a child. The saltwater on your sunburnt legs. Sometimes the water is yellow, sometimes it's red. But what colour it may be in memory, depends on the day. I'm not going to tell you the story the way it happened. I'm going to tell it the way I remember it.
The Lizzie Bennet Diaries is an innovative, original episodic video and social media series produced for the web. Adapting Pride and Prejudice to the modern era, Lizzie Bennet tells the classic Jane Austen tale from the point of view of an Elizabeth "Lizzie" Bennet who grew up in a world of cell phones, video cameras, and social media. The series was created by popular YouTube personality Hank Green and Streamy Award winning web video writer Bernie Su.
The holiday season is bringing more than cheer for actress Jessica Capshaw. The Grey's Anatomy star announced on Monday that she and her husband, Honest Company co-founder Christopher Gavigan, are expecting their fourth child. "The holidays have certainly arrived … All of our lives are being added to by the lights, the music and cheer!!" she captioned a photo of her family at a Christmas tree farm on Instagram. "This year our family has reason to further broaden our smile … baby number four is on the way!! I am a lucky, lucky girl…"
The quickest way to tell whether an actor is serious about his or her career is to look at their "headshot".Is it a professional photo? Or is it a snapshot taken on prom night? If you're using a snapshot, it's like showing up to race the Indy 500 in a VW Beetle. Nobody is going to take you seriously. I'm sorry, people… you can send me as much angry e-mail as you want about this, but it's true! Don't tell me you're destined to be a major Hollywood star but you cannot scrape together the cash to get professional headshots.
The Grinch from Dr. Seuss' How the Grinch Stole Christmas! The Musical stole the spotlight at the Empire State Building's 86th Floor Observatory December 14, 2012, to promote the musical's limited holiday engagement. Discover the magic of Dr. Seuss' classic holiday tale as it comes to life on stage. Featuring the hit songs "You're A Mean One, Mr. Grinch" and "Welcome Christmas," The Grinch discovers there's more to Christmas then he bargained for in this heart-warming holiday classic.
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