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Irv Weissmans home is about 20 minutes from Stanford University, hidden from the road by a tall stand of trees. Inside, all of the rooms are spacious, but the living room is more so. The ceiling is high and broad-beamed; the furniture, Western chic: chairs hewn from tree branches, tables built from tree trunks. The couch is a curving affair that looks a little like a giant, gold earthworm caught in a pillow fight. Spread out in front of the fireplace is a bearskin rug. This bear has seen better days. Irv Weissman is talking about how those days came to an end.
We ate him. Rare. We were a little nervous about it because most wild bears have trichinosis, but what the hell.
Irv Weissman doesnt look the bear-eating sort. Hes of middle height, middle weight, mildly balding, with fine clothes, a jovial aspect and a long, wispy beard. He is a scientist, yet looks more like a Russian poet or an aged food critic. Beneath this exterior, however, hes just a boy from Montana -- the grandson of a Jewish homesteader who, upon arriving at Ellis Island, walked across the country and tried his hand at mining, fur trapping and eventually opened a hide shop that became a group of hardware stores; the son of a man who, when wounded by a knife-wielding assailant, was tough enough to fight back and beat the man silly -- so silly it made the papers. Which is to say Weissman comes from a culture of bear eaters.
So why is he living among Stanford academics and not in Great Falls, Montana, with other bear eaters? When Weissman was 10, he read Paul de Kruifs book Microbe Hunters, which describes the work of Ehrlich, Pasteur and other early bacteriologists. He quickly decided science was more interesting than hardware. By the time he was in high school, he worked at a lab in Great Falls doing transplantation research. He published two papers, on cancer and transplantation, before he was 18.
Weissman entered Dartmouth College but found that he didnt fit in with either the East Coast Jews or the East Coast non-Jews. After two years he transferred back to Montana State University in Bozeman, where he could study premed without worrying about how a Jew from Montana was supposed to behave on the East Coast. He left the state again in 1960, entered Stanford Medical School and one way or another has stayed for the duration. Currently, hes a professor of cancer biology and a professor of pathology. In 2002, he was voted California Scientist of the Year.
True to his roots, Weissman approaches science like a Montana boy -- charting unexplored realms, pioneering in the lab. His early work focused on how the cells of the immune system fight cancer. He spent much of his time studying the relationship between blood cells, cancer and radiation. Because of the research that emerged after the explosion of the atomic bombs over Hiroshima and Nagasaki, scientists knew that exposing the human body to radiation wiped out both blood cells and cancer cells.
They also knew that after irradiating the body (chemotherapy), you could perform a bone-marrow transplant using marrow from a healthy, cancer-free donor and that something in that new bone marrow would begin producing all sorts of cells. We knew there must exist a very rare cell inside the bone marrow that would give rise to all types of cells -- but this was only a theory, says Weissman. No one had ever isolated that cell. I started wondering how to tease it out from all the others.
This was in the late 60s. For years, Weissman worked in his lab sorting cells. An easy way to think about this is that he took mouse blood and poured it through a long series of strainers. With each pass a different kind of cell was removed. Out came the T cells, out came the B cells, the red blood cells, the white blood cells and on and on until there was only one kind of cell left. Finally, in 1988, Weissman managed to do something that no one else had ever done, something that most people didnt even think was possible: He isolated a cell that gave rise to all other kinds of blood cells, a blood-forming stem cell. He also became one of the first people on the planet to realize the promise of what he had done. This has made him a controversial man.
If youve been living inside a Himalayan cave, perhaps you havent heard about stem cells, but otherwise the gist has been hard to miss. Scientists from all fields have been harping on stem-cell research as the most important directed medical-research effort ever. When Irv Weissman started working with mouse cells, he realized, nearly from the beginning, that he was onto something that could potentially save millions of lives. I knew that if I could ever do this in humans, he says, I would be able to use chemotherapy to wipe out cancer cells and then transplant in new stem cells that would be completely disease free.
Cancer wasnt the only thing on his mind. Weissman knew that a great number of the bodys terrible diseases -- Alzheimers, diabetes, Parkinsons, others -- are caused by misbehaving cells and that it might be possible to remove the bad cells and replace them with normally functioning stem cells. In America, 1.3 million people have cancer; 4 million have Alzheimers; 1.5 million have Parkinsons; 17 million have diabetes. This doesnt include those in need of a new kidney or bladder or spinal cord -- which stem cells could possibly be used to grow. Thats a lot of lives to save.
What Irv Weissman didnt understand at first is that his own government could politicize these stem cells and decide that potentially saving millions of lives was a bad idea. What he didnt understand then, but has come to understand since, is that without his rugged Montana perseverance, he might not ever get the chance to save these millions of lives.
R. Alta Charo, a professor of law and medical ethics at the University of Wisconsin, Madison, who served on Bill Clintons bioethical council and who has been a part of this discussion since nearly the beginning, likes to say, The stem-cell debate is a debate about everything but what its about. Which is to say that the stem-cell debate is not, actually, about stem cells.
Really, it is about George Bush trying to win a second-term election after not actually winning the first. Its about the son not making the same mistakes as the father and losing the religious right. And its about the religious right trying like hell to pave the way for the Supreme Court to take away a womans right to have an abortion.
A discussion of this requires a little more background on the five ways scientists obtain stem cells. The principal method is through a process called somatic cell nuclear transfer, which well get to in detail soon. But for now well concentrate on the other four. One of those ways is through parthenogenesis, the Greek word for virgin birth. In this process, an unfertilized egg is tricked into cell a division and then mined for stem cells. Another way is to take one of the existing 60 cell lines and form another cell type to create new lines. Both of these ideas are exciting, but no one really knows if or how well either will work, and so, for now, both are off the radar.
In the remaining two methods, fetal stem cells are culled from aborted fetuses and embryonic stem cells are removed from unused embryos taken from in-vitro fertilization clinics. Because of these methods, stem cells sit smack in the middle of Americas reproductive-rights debate. In fact, some have argued, the debate over the process of culling stem cells is the best thing to happen to the religious rights anti-abortion crusade in decades.
Every year since Roe v. Wade thousands of women have been having abortions, explains Charo. Thats 30 years, an entire generation of women who have experienced the ability to choose. Thats a huge demographic imperative. The evangelical right is fighting against a culture of tolerance for embryonic destruction, and theyre losing that fight every time a woman knows she can make a choice. The conflation of cloning and stem-cell research has allowed [the religious right] to argue for the embryo in the context of a technology -- reproductive cloning -- that has a near-universal shock value.
Its a tricky thing to try and overturn a Supreme Court decision like Roe v. Wade. Nonetheless, for 30 years, foes have been chipping away at it. One of the main reasons it has held fast hinges on this idea: A human embryo does not have the same rights as a human being. To overturn the decision you need at least a couple of things. One is a pro-life Supreme Court (which is a whole other can of worms, but it starts with what we just got -- a pro-life Senate). The other is evidence that supports the idea that the American public now feels that embryos are people too.
For the benefit of reporters and congressmen locked in this debate, Irv Weissman does an interesting experiment. He walks up to strangers on the street and asks them to draw an embryo. Invariably, he says, every time, without fail, they draw a fetus with a face. A fetus with a face is not an embryo. An embryo is a scientific term used to describe the period of time from when a zygote is formed until the time it begins to have discernible organs. Meaning, specifically, that the word embryo was created to distinguish it from a fetus. It is nothing like the cartoons that people draw. In fact, under a microscope, an embryo is even less spectacular than stem cells.
If you want to prove to the Supreme Court that both the scientific community and the American public have changed their minds about the status of the embryo, then you need a series of precedents. These are not just legal precedents; these are psychological precedents as well. The high court would need to decide that the countrys opinion has changed, and to do this you would need to show that in related -- but not abortion-specific -- departments the embryo is now being afforded the same protections as both fetus and adult.
To this end, Bush has stacked a bevy of anti-choice judges in the lower courts and appointed an anti-choice attorney general in John Ashcroft. And while you could argue that this is just party politics -- and it is -- behind the obvious partisan court appointments there are covert anti-choice precedents being set.
Last October, the Bush administration changed the section of the Health and Human Services charter that regulates research done on human subjects. This legislation exists so that if you volunteer for a sleep study, you dont end up dead. The old charter granted legal protection to adults and fetuses. The new version protects embryos as well.
For a long time, womens groups have been lobbying the government to provide health care for pregnant women. To this end, the Bush administration extended the reach of the State Childrens Health Insurance Program to cover both embryos and fetuses but, oddly, not pregnant women. So, while pregnant women still can be without health care, the groups of cells dividing in their uteruses now have more health coverage than their uninsured mothers.
Bush has also lobbied hard for a ban on partial-birth abortions, which technically eliminates the already rare late-term abortions but in effect criminalizes the procedure. Bush also reinstated Ronald Reagans gag rule that bars federally funded family planners from discussing abortion as an option or from providing abortion services.
The point of these things, says Allison Herwitt, director of government relations for the National Abortion and Reproductive Rights Action League is to weave embryonic rights into law. These are not individual occurrences. These are a well-crafted strategy to end legal abortions. And one of the next steps in that strategy is to outlaw stem-cell research -- not because the research itself is in question, but because banning the way that research is conducted can help them to achieve their true goal.
Under a microscope, stem cells arent much to look at. They grow in clusters and even when magnified 10 times are individually smaller than pinheads. They look like slimy, slightly metallic grapes. Under a microscope, it would be easy to mistake them for something utterly inconsequential, like tadpole snot.
Its almost funny, says Larry Goldstein, that something so dull-looking could cause such a fuss.
Goldstein, another scientist in the middle of this stem-cell storm, is a plain-spoken, energetic man in his late 40s. He has gray hair and a long, handsome face. As an investigator and professor of cellularmolecular medicine at the University of California, San Diego, he oversees a lab that employs 23 people and thousands of mice. Both mice and men are working toward answers to the same set of questions: how biological complexes (proteins, lipids and organelles) move through the neurons and brain cells.
He wants to know these things because he thinks the answers will go a long way toward providing a cure for Alzheimers, Huntingtons chorea and Lou Gehrigs disease. To get the answers, he needs stem cells.
Stem cells are the bodys rawest materials. From them, developing embryos build all other cells that eventually form the body. Unlike specialized cells that can only form one thing -- a liver, say, or a nose -- stem cells can change into any other kind of cell.
Currently, much of Goldsteins work involves non-human-derived stem cells, which are not technically a point of contention. But five years from now, if I want to actually cure these diseases, Ill need access to human embryonic stem cells, and I want to make sure theyre available.
The issue of stem-cell availability is at the root of a war of terminology. Both sides are using big words, and some of those words have frightening connotations. Ignorance is part of the problem. Because of the complexity involved, the media often choose brevity over accuracy, and the combatants fuel the war by co-opting partially a defined words to their own ends.
Cloning is one of the biggest bombs in this terminology war. You have to understand something, Weissman says. Cloning has as many meanings to a scientist as ice to an Eskimo or love to Oprah Winfrey. On the other hand, cloning, to a man like Leon Kass, means only one thing: producing carbon-copy human beings.
Leon Kass is yet another controversial man at the center of this battle. He is a University of Chicago bioethicist who believes that life begins at conception and who now heads up President Bushs Council on Bioethics. Time magazine called him the presidents ethics cop. The council is charged with advising Congress and the administration on stem cells. A few years ago Kass wrote a now-famous article for The New Republic titled Preventing a Brave New World or Why We Should Ban Human Cloning Now. He explained the aforementioned procedure called somatic cell nuclear transfer (SCNT), the principal means of obtaining stem cells, and disingenuously equated that process with the cloning of people. Here are a few lines taken from Kass article:
What is cloning? Cloning, or asexual reproduction, is the production of individuals who are genetically identical to an already existing individual. The procedures name is fancy -- somatic cell nuclear transfer -- but its concept is simple. Take a mature but unfertilized egg; remove or deactivate its nucleus; introduce a nucleus obtained from a specialized (somatic) cell of an adult organism. Once the egg begins to divide, transfer the little embryo to a womans uterus to initiate a pregnancy. Since almost all the hereditary material of a cell is contained within its nucleus, the re-nucleated egg and the individual into which it develops are genetically identical to the organism that was the source of the transferred nucleus.
Scientifically, Kass is correct, except -- and this is a big except -- SCNT stops short of transplanting that egg into a womans uterus. What Kass knows, but chooses not to acknowledge here, is that once that new egg begins to divide, one of two things can happen. The first is it could be implanted into a womans uterus and develop those dreaded carbon copies. This process is called reproductive cloning, and almost every mainstream scientist the world over, including Weissman and Goldstein, opposes it.
The second thing that could happen is what opponents of this work like to call therapeutic cloning. Weissman prefers nuclear transplantation to produce stem cells. Either way, in this second scenario, once that very early embryo (a cluster of 100 or so cells called a blastocyst) is formed, there is a two-week window during which the stem cells are extracted. In doing this, the embryo becomes unsuitable for manufacturing the dreaded clones, or any other viable human form for that matter. If you wanted to create another human being, you would have about as much luck successfully implanting that enucleated embryo into a womans uterus as you would have growing a Buick by planting an engine block in the ground.
Kass apparent attempt to equate SCNT with the production of cloned individuals becomes egregious because his knowledge and opinions are being used to enact legislation that will then affect the entire country.
A clear indication of Kass sway took place in the spring of 2001, when a pair of cloning bills was introduced, one in the House and one in the Senate. The original House bill went nowhere, but it was quickly rewritten and reintroduced by Dave Weldon (R-Florida). On July 31, 2001, after three hours of debate during which conservatives spoke about eugenics, commodifying humanity, the peril of private-industry control over the human genome, the need for science to operate within social and ethical norms, and -- of course -- the Nazis, the House of Representatives passed the Weldon Bill 265 to 162.
The bill (and its sister Senate bill, which was introduced by Kansas Republican Sam Brownback and is known as the Brownback Bill) seeks to outlaw all forms of cloning -- both reproductive and therapeutic -- with severe penalties of up to a $1 million and 10 years in prison for either doing research or receiving medical treatment based on that research. This means that if the French invent a stem-cell-based cure for Alzheimers and you go to France and receive treatment and try to re-enter the United States, youre not passing go, youre going straight to jail. The only good news is that since your Alzheimers is now cured, youll remember the whole experience.
On August 9, 2001, President Bush, in his first address to the nation, echoed Kass fear-mongering and followed his lead: We have arrived at that brave new world that seemed so distant in 1932, when Aldous Huxley wrote about human beings created in test tubes in what he called a hatchery.
Bush then issued an executive order restricting federal research money to the 60 previously harvested stem-cell lines. These lines were cultivated between 1998, when human embryonic stem cells were first isolated, and the moment Bush put the kibosh on further work. Never mind that the majority of these lines have not been studied enough to know if theyre actually safe for use in humans.
But the real problem with them, says Weissman, is that all 60 lines come from people who utilize in-vitro fertilization clinics. Part of the problem is IVF clinics serve a very specific segment of the American population. The stem-cell lines taken from IVF clinics are cell lines taken from rich, white, infertile people. We have no idea if stem cells possess ethnic, genetic variation -- and they might. One of the fundamental principles of bioethics is called distributed justice. That means when scientists work on medical cures, they want to develop cures for everyone -- not just for rich, white, infertile people.
In other words, scientists want to study a rainbow coalition of stems cells, but by limiting research to existing lines, compassionately conservative George Bush has created a stem-cell policy much like his tax cut: The rich get richer, the poor get screwed.
Spend five minutes with Jerry Zucker and youll think that his life could have gone either way. One wrong turn and he would have ended up still working the coat check and living with his mother at 50. He wears cardigans. In conversation, his voice is several decibels below soft-spoken. Words hang up on his lips. He has soft features, bushy eyebrows, errant hair and, all told, looks like someone in constant, mild pain. The one thing he doesnt look like, and this may be his great genius, is Hollywood royalty, or at least its court jester.
Zucker created his own brand of movies, a genre of wack-job comedy that began with Kentucky Fried Movie, was perfected in Airplane! and which includes the Naked Gun and Police Squad franchises. He also a made a sweet movie about a dead guy, a live woman and a pottery fetish called Ghost.
Zucker Productions is a few modest rooms located in a peach-walled building in Santa Monica. Zuckers movies are such flamboyant affairs, its hard to imagine them beginning in rooms this small.
Its also hard to imagine Zucker as the political type. Though he attended the University of Wisconsin from 1968 to 1972, when Madison was a radical hotbed (the legendary Vietnam protest documentary The War at Home was filmed then and there), Zucker was, by his own admission, never much more than a weekend rioter. His politics are still middle-of-the-road.
Since then, not much has changed. Yet everything has changed. In 2000, Zucker found out that his 11-year-old daughter, Katie, had juvenile diabetes. Immediately, he began researching the disease and hunting for hope. In the summer of 2001, he started hearing about something called stem cells and how they might be able to not just provide better treatment, but actually cure the disease. That summer he also heard that the Weldon Bill had passed, that President Bush was limiting research to 60 mostly moribund cell lines and that the Brownback Bill was heading for a vote in the Senate where only seven members were in favor of keeping the research legal.
As a director, says Zucker, I tend to be calm. I dont want to be another Hollywood maniac. I try not to get carried away or lose my cool. What was going on with stem cells made me very angry.
Through sad coincidence, Zucker and his wife, Janet, had gotten to know Douglas Wick (the producer of Gladiator, Stuart Little and Working Girl), and his wife, Lucy Fisher, the former vice chairman of Columbia TriStar Motion Picture Group. Wick and Fisher also have a daughter with juvenile diabetes. The foursome had been active in the Juvenile Diabetes Research Foundation, but wanted to be at the forefront of the stem-cell debate and felt that if they started their own organization they could not only act quickly, they could bring the full weight of Hollywood to bear on the situation.
Together they hired a lobbyist and went to Washington. They took their daughters and Caltech stem-cell biologist David Anderson along. They called this new group CuresNow. This was in the summer of 2002. To give you an idea of how strong the love affair between D.C. and Hollywood is, what did CuresNow do to get in to see senators?
Um, says Zucker, I just called up and said this is Jerry Zucker.
They looked at their trip as an educational crusade. They punched below the waist. We would walk in to a senators office with my daughter and her insulin pump attached to her belt and ask them what was more important -- my daughters life or the life of a couple of cells?
In a sense, CuresNow was fighting against the work of its founders business. In the minds of many, stem cells are directly linked to cloning, and the public perception of cloning is directly linked to Hollywood. We spent the better portion of the 20th century making mad-scientist movies, says Zucker. One of the first senators we met -- I cant tell you his name -- went on and on about how if we let this technology go forward someone will try to create a new Hitler. How much of that is real fear and how much of that is Hollywood?
As they suspected, most of the politicians didnt really know what they were voting on. The Hollywood crew explained things slowly, and slowly began making headway. One of their early converts, who remains their strongest ally on the right, was Utah Republican and pro-life advocate Orrin Hatch. Centenarian Strom Thurmond joined their cause. Senate Minority Leader Tom Daschle agreed not to put the Brownback bill on the floor for a vote until CuresNow had a chance to talk to everyone who would listen.
Hatch, alongside several other senators (Feinstein, Kennedy and Specter), introduced his own bill that banned reproductive cloning but allowed therapeutic cloning. Neither his bill nor Brownbacks could gather the votes needed to pass. Instead, Brownback tried attaching anti-cloning to several other bills, but CuresNow was making headway. The word was getting out, and none of the anti-cloning amendments have met with success. Currently, 60 senators favor stem-cell research, and the Senate vote is still pending.
Since the recent Republican gains in Congress, CuresNow knows that its Washington work is not done. But Zucker and company are spending an equal amount of energy in California because its here that lines are being drawn and the first major battle for stem-cell research is being fought.
California is the countrys biotech leader, says Zucker. We have brilliant scientists and a receptive state government. I want to see California as a safe haven for stem-cell research. We have a history of leading the nation in fights such as this. We have a great chance to add to that history.
The 10th Amendment to the U.S. Constitution reads: The powers not delegated to the United States by the Constitution, nor prohibited by it to the States, are reserved to the States respectively, or to the people. Politically, this is the typically Republican turf known as states rights. It exists as a barrier to top-down, Washington-mandated policy. It is the legal reason California was able to legislate lower emission standards than the national standards mandated by the Clean Air Act. The rest of the nation followed Californias anti-emission movement; car manufacturers, to their dismay, had to comply. California Democrats had used one of the Republicans favorite weapons -- states rights -- to spark a state-by-state subversion of the GOPs big-auto agenda.
This tactic doesnt always work. In 1996, California passed Proposition 215, making marijuana available with a note from your doctor, like any other prescription drug. In the ensuing years, nine other states legalized medical marijuana. George W. Bush promised in a 2000 campaign speech to leave medical marijuana as a states-rights issue, saying, inimitably, I believe each state can choose that decision as they so choose.
But in May of 2001, the U.S. Supreme Court in U.S. v. Oakland Cannabis Buyers Cooperative ruled against the 10th Amendment, and in 2001 the Drug Enforcement Agency started raiding Californias buyers clubs and growers organizations, confiscating wares and imprisoning owners.
It doesnt take an astute political analyst to realize that two of the engines driving the Republican Party are economics and morality. There are many different ways of looking at the conflicting tales of emissions and medical marijuana. The least cynical is to believe that the country was ready for cleaner air and not ready for legalized drug use. A more jaundiced view says that pollution laws had two things going for them -- they didnt contradict federal law and, since Californians buy more cars than anyone else, compliance carried an enormous economic incentive. Medical marijuana, on the other hand, goes against federal law and also lacks an economic impetus since you cant tax its sale. Most important, it offends the moral standards of the right.
The California biotech industry is a huge economic impetus. In 2001, when President Bush limited stem-cell research to the 60 previously existing stem-cell lines, he effectively yanked a huge segment of biotech research to a dead halt. Moneys were drying up, and Americas top scientists began leaving the country and moving to places with fewer restrictions -- an effect that analysts quickly dubbed the brain drain.
Almost immediately following Bushs August announcement, University of California at San Francisco stem-cell pioneer Roger Pedersen packed his bags and lab and moved to England, where stem-cell research is permitted. Other countries, including Israel, Japan, France and Australia, have made themselves friendly to the work. Last year, Singapore took an even more aggressive stance, declaring itself a center for stem-cell study, breaking ground on a $15 billion research park and quickly poaching top U.S. minds including Edison Liu, once a leading researcher at Americas National Cancer Institute and now the head of Singapores new Genome Institute. Theres even talk of an international consortium for stem-cell research similar to the one that cracked the human genome.
To combat the brain drain and bring more biotech money into California, state Senator Deborah Ortiz (D-Sacramento) introduced Senate Bill 253. The bill allocates the use of state funds and private donations for stem-cell research within California.
If your idea of a senator includes gray hair, a stentorian voice, pinstripes and steely eyes, then Senator Ortiz does not fit the bill. She looks like a suburban housewife and acts like an endearing grandmother. On the day we met, she arrived carrying Greek pastries that looked like failed geometry experiments oozing filling. She is an easy woman to underestimate. One gets the feeling that she spends her days nudging legislation into law.
In her day, she has nudged quite a bit of legislation into law. In 1993, she was elected to Sacramentos City Council and fought a nasty fight for safer neighborhoods and tougher gun control. In 1996, she was elected to the state Assembly. That same year her mother was diagnosed with ovarian cancer. In the Assembly, Ortiz gave state workers a long-overdue pay raise and created a statewide after-school learning program for at-risk students. At home she became an armchair cancer specialist. I read all the studies and I read the footnotes. But there was no cure in the footnotes, and her mother died in 1999 during Ortizs first state Senate term. Knowledge led her toward advocacy. Ortiz earmarked $25 million for ovarian-cancer research, but felt that wasnt enough.
From the footnotes I came to believe that the cure for cancer has to exist at the cellular level, Ortiz says. Stem-cell research is the next wave. When she was re-elected to the state Senate in 2002, she turned her attention to stem cells. It wasnt just a cure for cancer that drove her decision. She knew that California took a $12 billion hit in the dot-com crash, and recent studies claim that the states budget deficit will exceed $35 billion in the next year and a half. On September 22, 2002, Gray Davis signed SB 253. Ortiz had nudged perhaps her biggest bill into law. California became the first state to legalize stem-cell research.
By signing SB 253, we have opened the door to important life-saving research in California, said Davis, when asked about the bill. There are strict parameters to stem-cell research built into the bill, but the possibility of some of the industrys top science researchers finding a cure to fatal diseases such as Alzheimers and Parkinsons diseases, spinal-cord injury, stroke, burns, heart diseases, diabetes and arthritis is priceless. We fully expect stem-cell research to attract world-renowned scientists to our state. Currently, there are 2,500 biomedical companies in California that employ 225,000 people. During 2000, this industry paid its employees $12.8 billion. While this life-saving research will continue to bring the necessary [private] funding into the state, it will more importantly save lives.
Almost immediately after Davis signed, other states followed Californias lead. New Jersey, Pennsylvania, Louisiana and Rhode Island have already legalized therapeutic cloning, and Massachusetts and New Mexico are considering similar proposals.
This grassroots, states-rights movement on stem-cell research presents a dilemma for Republicans. The old-school, economic Republicans are interested in free enterprise and biotechnology -- the economic imperative. The new-school, moral Republicans are interested in homogeneous morality and banning abortion. Stem cells split the two sides of the party. One of the reasons for the terminology war is that the Bush administration needs to create a cloning bogeyman in order to bridge the schism in his party. This way he appeases the moralists while doing an end run around the economists who would be rather pleased with biotech billions.
It is interesting to note that there is no Bush administration or religious-right opposition to the in-vitro fertilization process, despite the fact that in the normal course of in vitro, multitudes of embryos are destroyed. During in vitro, ova that have been extracted from a womans body are fertilized in a petri dish. On average, 20 or so embryos are created, but only one is implanted. The rest are temporarily frozen and then eventually discarded. This means that while the administration and the religious right are opposed to using those ill-fated embryos for stem-cell research, they are more than happy to turn a blind eye to their destruction in the name of pregnancy. This is because their anti-abortion legal strategies call for defining life ever earlier and ever more clinically -- as early and clinically as a dish in a refrigerator (talk about weird science). Also, they do not wish to confront sterile parents or hamper a multimillion-dollar industry.
So sure, its a tad dramatic to say that what followed SB 253 is a high-stakes poker game with states rights, Bushs second term, abortion legality, the biotech industry and medical science as major players. In less dramatic language, whats happened in California is that the two key issues driving the Republican bus have come into head-on conflict with each other, and its because Democrats have forced the issue by playing the states-rights card.
Just before Davis signed Ortizs bill into law, Andy Grove, the chairman of Intel, donated $5 million to UCSF for a stem-cell biology program. Because of Bushs restrictions, anyone wanting to do stem-cell research requires facilities that are completely unattached to anything receiving National Institutes of Health dollars -- thus separate buildings, labs, equipment and such must be constructed. The $5 million wont pay for much of that, but it was the first major private donation and a good start.
In Irv Weissmans home, on the evening of December 11, a small dinner party was held to celebrate the next step -- that being Stanfords announcement a day earlier that it plans to capitalize on $12 million of anonymously donated seed money and build a $120 million Institute for CancerStem Cell Biology and Medicine headed up by Weissman. Building on his previous research with blood-forming stem cells, the Stanford institute will initially turn its attention to discovering the stem cells that become the other major organs of the body -- that way, if these organs become cancerous, theyll have new ways to fight the disease.
Weissman does not look like a man in celebration. His movements are careful, his brow creased. He wears a chefs apron and stands at the stove, studying the goose hes been busy cooking.
Around the dinner table sits a hungry crew. Weissmans sister Lauren, once a Hollywood producer with five major films to her credit and now the executive director of CuresNow, is there. As is Lee Hood, another top scientist and the man who invented the DNA sorter that facilitated the sequencing of the human genome; and Ann Tsukamoto, a scientist with StemCells Inc.
Weissman maintains a robust wine cellar, and there are a number of prestigious bottles sitting unopened on the counter and a number sitting opened on the table. In between gobs of goose and glasses of grape, Weissman explains the focus of Stanfords new research institute.
Its not only new ways to fight the disease, he says. Thats only the first step. We also know that there are cancer-forming stem cells. If we can isolate these, we can get to the very root of every type of cancer. This would give us new, biologically specific targets for drugs. And because the institute is in this state, California will be the first place these therapies will come out. Our biotech companies will produce them, and Californians will get the first crack at these treatments.
Even this is only the tip of the iceberg. The institute plans to improve the efficiency of SCNT, and once thats done they can begin growing diseases from scratch -- which means theyll develop a fundamental understanding of how the body gets sick. So, when the Bush administration says it opposes all forms of cloning, it is, in effect, saying it opposes the best bet yet for curing cancer.
As expected, Stanfords announcement sparked a firestorm. All of the top papers and top news shows reported the story, but not one bothered to explain the tie-in between the stem cells and cancer. Instead the words human cloning got heavy play. The Associated Press was the first to cover the story, and its article began: Stanford has said its new cancer institute will conduct stem-cell research using nuclear-transfer techniques -- work that many consider to be cloning of human cells. ABC News followed suit: The president believes that the creation and destruction of embryos for the purpose of research or reproduction is morally wrong. He is against cloning of any kind and feels there are other biomedical-research avenues.
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Leon Kass immediately issued a press release claiming that Stanford has decided to proceed with cloning research without public scrutiny and deliberation, and went on to say that the presidents bioethics council does not endorse the Stanford institute, and then noted the council wanted a four-year moratorium on so-called therapeutic cloning. Oddly, the council never recommended a moratorium (which Brownback has recently been calling for and which stem-cell researchers across the board consider a terrible idea), and Kass issued his statement without bothering to consult the rest of the council.
Not that any of this behavior is all that surprising. This is just a little lying in the face of a bigger war -- a war that is far from over. The cloning debate rages on at all levels of government, refueled by the recent Raelian announcement that they had created the worlds first human clone. Never mind that, just prior to that announcement, the Bush administration blocked a worldwide U.N. ban on reproductive cloning that might have stopped the Raelians in their supposed work. The ban was vetoed because it did not also include therapeutic cloning and was insufficient for the religious right.
So the opposition continues twisting terminology. Scientists like Larry Goldstein and the folks sitting around Weissmans dinner table are painted as cold-blooded and immoral. The government is actively clouding the issues, and the media has done little to engender understanding. Meanwhile, a middle-of-the-road estimate of how many Americans will die from diseases that stem-cell research might soon cure is 130 million.
Back at the stove, Weissman pokes and prods and eventually nods his head sagaciously: That goose is cooked.


text:
Opinion: The Campus Left Moves Left
Claremont Review of Books Editor Charles Kesler on how the idea of "tolerance" on college campuses can lead to suppression of free speech. Photo credit: Associated Press.
This transcript has been automatically generated and may not be 100% accurate.
... I ... welcome to Opinion Journal on Dan Henninger sitting in for Mary Kissel and I'm joined by Charles Kessler's senior fellow at the Claremont Institute and editor of the estimable Claremont ... review of books ... but Charles is May and that means we're going to be graduating college seniors it also means of course we are protesting and counseling commencement speakers and ... other particular interesting couple once this of this your alley her see the Somali Ryder was so ... forbidden to speak at Brandeis she's a critique of by some of the extreme Islam and Brandeis said that she would violate what they call their ... core values ... are interesting one steamy was the Charles Murray on his talk to is is the Pacific was ... postponed ... and the reason given there was that ... Larry's remarks whatever they thought he was going to say it might be ... hurtful to some members of the community there ... gotchas human around the college a few of the ecologists your entire career with the use to be that the lap protested big things like the Vietnam War ... how was this endless what is going on ... well it the protesting big things would mean protesting Obama ... right now ... and that's off limits ... um and it's not so much because I'm ... it said controversy all among the students as that I think it is simply a ... date I say I mean it's not something that somebody would even think of doing in polite company ... and that leaves a lot of other things smaller issues to worry about ... and it's a you know Bill Buckley once at its IPO ... but a person who runs the ... who boost recruiting a hope or House worried about bed bugs ... in India and the content for a university is so shot through with ... leftism and toleration than many good things as well as bad things that ... have happened to America since the sixties ... that the idea that there could be that that happens to be the home of the this thriving racists communities and ... homophobic ... sales and support ... is extremely hard to believe in it just isn't true but the but in the in the ... perfectionist ... thinking of the left ... the scene of the least it's an ... outlook calls for the heaviest kind of punishment because you're looking for perfection well one of one intriguing development side is that of the historically in recent years last twenty years or so most of this is been directed at conservative professors ... but not all they're talking about on asking the professors of thought everyone on the ... campus ... list something called trigger warnings on their courses so that anything in the content that might injure or hurt someone for reasons of gender race ethnicity politics can opt out and ... professors are being called the lookout ... for these offenses ... yes it's ... obviously a can of course you would have the student a reading list ... and that's all it was a list of the books you are going to read that that course ... now you know it's like them ... the lawyers have gotten involved ANSA every syllabus is supposed to have warnings aspires to have a ... minute ... you know details about when things are too and how much this book now how much that will help ... but it's up ... in the whole project really goes back to the nineteen sixties into the new left ... that you are ever Mark Reuss and was one of the gurus of the ... of the new left ... arm wrote a very inching essay called repressive tolerance ... and that's really the key to what's happening on campus is now ... at his argument was ... toleration use to be a progressive thing ... when the Conservatives ruled the country ... but once liberals rule the country ... and are prepared to tolerate everything including radicalism ... of the zero tolerance becomes reactionary ... stance of tolerance on university campuses which is to be the goal ... of liberals ... now becomes a nap ... now it's the conformity ... on campuses that they say now ... Arike Charles stay with me Ramsay a quick break

subset: commoncrawl


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text:
|OpenBSD Packages and Ports Installation and upgrading of packages and ports on OpenBSD.
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Midori port
I've been using OpenBSD for about month on an IBM T22 laptop i had laying around. When I try and build Midori from the ports I get the following error:
checking for gcc... /usr/ports/lang/gcc/4.2/w-gcc-4.2.20070307/bin/egcc checking whether the C compiler (/usr/ports/lang/gcc/4.2/w-gcc-4.2.20070307/bin/egcc -O2 g ) works... no configure: error: installation or configuration problem: C compiler cannot create executables. *** Error code 1
"The basic tool for the manipulation of reality is the manipulation of words. If you can control the meaning of words, you can control the people who must use the words." -Philip K. Dick
Like a few new ports, midori/webkit is a W.I.P.. which unfortunately will not compile with the system compiler. (It needs GCC 4).
That error would seem to indicate some sort of environment problem, as I've built a cross-compiler independent of the ports system before.
Sorry I couldn't be of more assistance..
I was using Midori for a month and removed it because of the stability issues.
If I recall correctly I used snapshot of packages to install it.
I have not noticed people complaining on ports[AT]openbsd about broken
Midori port so I would have to suspect that something is messed up with your system.
Without additional information about your system it is very hard to say
why is compilation failing. Grub the latest snapshot of the OS and latest
ports tree to make sure everything is in sync.
Looking at the makefile for Midori, I don't see any requirement for gcc 4.2; so I'm going to guess that your gcc 4.2 is actually getting in the way of the default compiler during the configuration step.
Midori has changed between 4.4 and -current; it's not clear from your problem description what you are running. If you are running -current in amd64 or i386, at the moment there is a -current package for midori for those archs available from your nearest mirror that has -current packages:
i386 built December 13
amd64 build December 17
Midori needs to be compiled with GCC 4 because the Webkit library is.. at least I think that's the case.
It's a sad cruel world.. but we gotta live in it.
sorry, i'm running 4.4. I was reading on how to track current ports so I could see if doing that would correct my problem. I'd like to run the newer version of midori that is in current but without having to rebuild my entire system to current...
"The basic tool for the manipulation of reality is the manipulation of words. If you can control the meaning of words, you can control the people who must use the words." -Philip K. Dick
$ make print-build-depends
Sorry about that.
I should note:
"Upgrading" from 4.4-release or 4.4-stable to -current is fairly easy.
Step 1: back up your OS
Step 2: "upgrade" to most recent snapshot
Step 3: run sysmerge
Step 4: Check the "Following -current" FAQ for anything sysmerge might have missed.
At that point, you may optionally upgrade installed packages to the most recently available prebuilt snapshot packages available for your architecture.
# pkg_add -iu
Since snapshot packages are never in sync with snapshots, you may find some inconsistencies which cause some packages to fail to install. The script(1) program in concert with col(1) is helpful for finding errors in the midst of hundreds of package upgrades.
Thanks to jggimi pointers I was able to upgrade my system to 4.4-current just too a week because of the machines speed...but I still get the same build error when trying to make the midori port and the package give a list of other errors.
I use no midori for me, thanks again.
"The basic tool for the manipulation of reality is the manipulation of words. If you can control the meaning of words, you can control the people who must use the words." -Philip K. Dick
If you are running either amd64 or i386, you might try installing the snapshot package -- no build required.
You'll find it in /pub/OpenBSD/snapshots/packages/<arch> at major mirrors.
Here's a list of some of the mirrors and their snapshot and snapshot packages dates:
I am aware of the age of this thread but it does pertain to a current problem.
On 4.8 RELEASE sparc64, I had the same problem.
What I did:
Remove the port.
Downloaded the source package.
Built the dependencies from ports.
Built and installed following INSTALL.
The browser still crashes due to not finding "default stock theme."
1.) I've read it calls upon the gtyk Tango theme.
2) I've also read it is the default browser for Xfce.
I'm using Xfce4 and Midori is still crashing.
(gdb) bt No stack. (gdb) core-file /home/boogers/midori.core Core was generated by `midori'. Program terminated with signal 11, Segmentation fault. #0 0x00000002170115dc in ?? () (gdb) bt #0 0x00000002170115dc in ?? () #1 0x00000002170115d4 in ?? () Previous frame identical to this frame (corrupt stack?) (gdb)
(gdb) bt #0 0x000000021161a348 in poll () from /usr/lib/libc.so.56.0 #1 0x000000020769dee8 in _thread_kern_poll (wait_reqd=Variable "wait_reqd" is not available. ) at /usr/src/lib/libpthread/uthread/uthread_kern.c:760 #2 0x000000020769f054 in _thread_kern_sched (scp=0x0) at /usr/src/lib/libpthread/uthread/uthread_kern.c:382 #3 0x000000020769b378 in pthread_cond_timedwait (cond=0x2078a41a0, mutex=0x2078a4198, abstime=0x20a969e68) at /usr/src/lib/libpthread/uthread/uthread_cond.c:431 #4 0x0000000207695ed8 in _thread_gc (arg=Variable "arg" is not available. ) at /usr/src/lib/libpthread/uthread/uthread_gc.c:181 #5 0x00000002076958d8 in _thread_start () at /usr/src/lib/libpthread/uthread/uthread_create.c:242 #6 0x00000002076958a0 in pthread_attr_setstackaddr () at /usr/src/lib/libpthread/uthread/uthread_create.c:234 #7 0x00000002076958a0 in pthread_attr_setstackaddr () at /usr/src/lib/libpthread/uthread/uthread_create.c:234 Previous frame identical to this frame (corrupt stack?) (gdb) next Single stepping until exit from function poll, which has no line number information. Program received signal SIGINFO, Information request. 0x000000021161a34c in poll () from /usr/lib/libc.so.56.0 (gdb) quit
It's an unfortunate fact that some software doesn't run as expected on architectures like the sparc/sparc64, they have strange memory alignment requirements and are big-endian.
POSIX threads also have some issues on OpenBSD that are being worked on, the OpenBSD kernel isn't aware of threads yet.. it's all implemented entirely in userland, the libpthreads library is just modular "uthreads" and "rthreads (kernel)" aren't in a separate library.
Midori on my (..mostly -CURRENT) i386/amd64 systems work fine, although it's not my #1 browser as of yet.. it's still a little rough around the edges, Firefox works better in most cases for me.
Posting debugging information like that here won't likely help, you should update to a snapshot and try a -CURRENT Midori package.. otherwise send an email to ports@ and the maintainer.
I'll return to it later.
before this was posted, there was no reference in Google for the memory addresses above; doesn't that seem a bit strange?
I'll ask the lists after I reboot the Sun Blade 1000.
How do I properly trace while running the program in gdb?
Pardon me if you're specifically a midori fan, but if you're looking for a webkit based lighter weight browser, have you tried Marco Peereboom's xxxterm? I'm not crazy about the vi command prompt as browser interface idea, but it does seem to be stable and starts up quickly. At least it starts quickly for something that's able to render better than dillo or lynx.
@Mr-Biscuit: You can't, not easily.. and debugging threaded programs in gdb is a real pita, not something a novice should try attempting.
Also, packages are generally stripped and/or built without debugging symbols.. so the gdb output is entirely unhelpful for debugging.
It makes no sense for you to continue further without having tested the -CURRENT port, sometimes things get broken and fixed.. bulk ports builds only happen occasionally on non-x86/amd64 platforms.
Thirdm: xxxterm works great, I just need to redo the conf file tweaks.
The log changes:
BSDfan666 (et al): I built the package from the website source with debugging. Whatever this default theme is doesn't seem to be in the search path for this version or the one in ports. I'll ask the maintainer if it has ever been tested on sparc64.
If anything on this reply seems sarcastic or biting....
it's not. I just woke up. My apologies for any misunderstanding.
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text:
Visits, Admit Days, and Open Houses / Re: texas law schools« on: April 01, 2010, 07:40:45 PM »
I attend school the University of Texas at Tyler. Without exception all of the people I have met on campus that want to practice law, want to attend law school in Texas (approximately 10 students). I personally did not consider attending law school outside of Texas until the pre law advisor encouraged me to look at colleges outside of Texas. I was wondering if it is normal for most students to generally only consider law schools in their state, is it a phenomenon unique only to Texas, or is it just coincidental that I know 10 other people that only want to go to law school in Texas?


text:
Jersey Addiction
Added Mar 18, 2014
by cris orange
Vienna, Austria
My jersey addiction goes on, I cannot stop!
I liked this dress in the burda magazin and also here in the forum there were some nice projects.
I made it of a quite light rayon jersey and for this reason I had to double the back skirt,
otherwise it would be too sheer.
I think for the same reason of the jersey beeing too light, the 2 pleats in front were flagging unflattering so I sewed them a few cm in the side seam.
But I´m still not totally happy with them, because I have to arrange them all the time.
I suppose for this dress some more stable jersey is needed.
I´ve also seen in the pictures that the back waist sits too low, maybe because of the weight of the double skirt???
One thing is sure: for this dress you really need high heels, otherwise it makes you rather wide…
Anyway, I like it and I want to try it in combination with other colours too :-)
Material Notes
Jersey: Rayon + Lycra
17 Comments Sign in to add a post
Sep 2, 2015, 11.39 AMby SassyT
To be shared on SSB Friday. Thanks for permitting. https://www.facebook.com/SassySewingBees
Jun 26, 2015, 07.29 PMby SassyT
Thanks I will let you know when,
Jun 21, 2015, 04.22 PMby SassyT
Would you mind me sharing this on SSB in the future? I link to your post and let you know when shared. https://www.facebook.com/SassySewingBees
1 Reply
Jun 21, 2015, 09.18 PMby cris orange
Ok, I don't mind :-)
May 26, 2014, 02.45 PMby trploceanmoon
I love the color! I have a heavy very dark green wool jersey that I have been wanting to use for this dress for a while. Would you recommend removing the folds on the skirt all together, and just replacing the bottom half for a plain pencil type skirt? I would love to know your opinion.
1 Reply
May 26, 2014, 03.03 PMby cris orange
thank you :-) well, I wouldn´t remove the pleats, because they make the dress more special. At the end I decided to sew the pleats on my dress, I still don´t have a picture of it but I´ll make one. Now I´m very happy with it, because it is still special but nothing flutters when I walk. Maybe with a heavy jersey this wouldn´t be necessary… and anyway you can make it first with pleats and if you don´t like it, you can remove them later, but give it a try :-) looking forward to see your version :-)
Mar 24, 2014, 10.31 PMby Luz Kettle
Gosh. So elegant. Great dress and great fit. x
1 Reply
Mar 25, 2014, 06.39 AMby cris orange
Thank you! Fitting with jersey is not a big deal :-)
Mar 24, 2014, 10.34 AMby Jelena Mitic
I'm also addicted to jersey :) I love the way this dress suits your figure, it's so elegant. I like the simplicity too.
1 Reply
Mar 24, 2014, 10.36 AMby cris orange
ohhh, thank you so much for the lovely compliment :-)
Mar 21, 2014, 10.41 AMby kaitiek
wow you look great!
1 Reply
Mar 21, 2014, 10.47 AMby cris orange
Wow thank you!
Mar 21, 2014, 06.01 AMby sewing fanatic
This is a beautiful dress, falls nicely, perfect
1 Reply
Mar 21, 2014, 08.16 AMby cris orange
thank you :-)
Mar 19, 2014, 02.15 PMby SassyT
Gorgeous. Looks like a powder blue.SSB. https://facebook.com/sassysewingbees
2 Replies
Mar 19, 2014, 02.16 PMby SassyT
I love blue, sky blue, anything blue.
Mar 19, 2014, 02.19 PMby cris orange
thank you Sassy, I also like blue (among many colours :-) but this kind of pastel blue was missing in my wardrobe :-)
Mar 19, 2014, 12.03 PMby liliv-1
Ultra chic, LOVE it!
1 Reply
Mar 19, 2014, 12.14 PMby cris orange
Thank YOU liliv :-)
Mar 19, 2014, 07.24 AMby Ellen Hatteland
Lovely Chris! The color suits you so well :) I've just made the same dress for a special party I'm going to attend :)
2 Replies
Mar 19, 2014, 07.45 AMby cris orange
Thank you Ellen! I'm looking foward to see your dress! Did you have the same issues with the pleats?
Mar 19, 2014, 08.02 AMby Ellen Hatteland
I have also used light jersey, but it's a jersey blend so it's not so soft, but I haven't been wearing the dress yet, so we'll see :) You look wonderful in your dress!
Mar 19, 2014, 05.11 AMby Mokara
I love the dress and it looks great on you. I also love the blue & yellow color combo… Thanks for sharing the information on the fabric and issues, etc.
1 Reply
Mar 19, 2014, 06.52 AMby cris orange
Thank you Mokara! I think this community is for sharing information. And yes, I like experimenting with colours, next time I'll try it with pink :-)
Mar 19, 2014, 05.00 AMby Denise Wild
This dress is gorgeous… the pale blue is perfect for spring!
1 Reply
Mar 19, 2014, 06.50 AMby cris orange
Thank you Denise! Yes, this pale blue is nice, I didn't have this colour in my wardrobe so far :-)
Mar 19, 2014, 04.02 AMby izbott
Good tips with sewing jersey. I am still getting the hang if it. You did well & looks good!
1 Reply
Mar 19, 2014, 06.49 AMby cris orange
Thank you! Jersey is great if you just know some tips in working with (I watched some classes on ceaftsy.com). I'm looking forward to see your jersey projects!
Mar 19, 2014, 12.34 AMby neveenkarnes
very nice… the shade of blue is beautiful. Well done !!
1 Reply
Mar 19, 2014, 06.45 AMby cris orange
Thank you!
Mar 18, 2014, 10.56 PMby Mary Athey
This is lovely on you cris, i love the blue shade as its so pretty. I made this and what i did with the excess fabric on the oragami front folds was to trim them. I found there was to much fabric around my middle once i did my folds so out came my scissors and i whacked the excess of. I don't need any extra padding lol. Yours looks so lovely cris and i just love them shoes x
4 Replies
Mar 18, 2014, 11.22 PMby cris orange
Thank you Mary! Yes, these pleats are a little bit strange, I've been thinking about sewing them by hand along the pleat, but I'm not very sure if this is good idea. But where is your dress, I didn't find it in your studio?
Mar 18, 2014, 11.33 PMby Mary Athey
Hi cris, its the red/ green one. Its the same dress but the version i used had the leather sleeves. You know how burda will do the same dress with just a slight variation like a different fabric. It is excatly the same x
Mar 19, 2014, 06.54 AMby cris orange
Oh, now I discovered it! It's a great dress! Does it have a pleat in front or have you cut it completely?
Mar 19, 2014, 07.43 AMby Mary Athey
Morning cris, yes it does have the pleats.i called it origami as thats what it felt like. I did the folds stitched then i cut away the excess on the inside and pressed the seams. You can't really see because of the fabric print but it worked a treat and gave a nice flat seamed finish. It worked great for me and when i get round to making a solid colour like yours i will do the same again. I could'nt make sence of the instructions, sometimes it's the way they are worded and sometimes it's me lol. I put the front section on my table and worked out what Worked by folding and pinning !! Leaving the front with the excess fold fabric would've meant me adjusting it all the time like you mentioned and that would annoy the life out of me on a night out lol x
Mar 18, 2014, 10.39 PMby rita61
Love the colour! Your dress looks nice on you !
1 Reply
Mar 18, 2014, 10.42 PMby cris orange
thank you rita, I also like this gentle sky blue :-)
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Worker killed, another injured at SC plant
Worker killed, another injured at SC plant
A man was killed and another has been injured in an accident at a paper plant, according to York County officials.
The accident happened around 1:30 a.m. Tuesday at the Resolute Forest Products plant in Catawba.
Authorities say 39-year-old Samir Storey and the other worker climbed into an old tank outside the main production area to do some maintenance work.
County emergency management director Cotton Howell said it's possible that some type of chemical leaked into the tank.
The other worker was removed from the tank and is being treated for injuries. His name and condition have not been released.
Howell said no evacuation was necessary.
The plant employs about 700 people and makes commercial printing papers and market pulp.


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Jun 27, 2018 Ali Hibbs Galleries, News, Schools
ALBANY — Bethlehem Central sent its Class of 2018 off in grand style with a graduation ceremony held at the Times Union Center on Saturday, June 22.
More than 300 students crossed the stage, each in a symbolic gesture marking his and her transition from student to graduate.
Click on one of the photos below to access our online slide show.
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I hear you on the last bit you wrote.How is nostalgia defined here? Isn't it more than just being a state of being homesick?The only potential issue I have is that I can be so caught up with nostalgia that it makes what I have now in a much dimmer light, eventhough I have it pretty good. The don't know what you have thing...There are certain songs I cannot play whatsoever, it just invokes something deep inside of me, a longing for the ignorance of youth and those songs just stir up a lot of sadness because I feel like that innocence is gone. Or the carefree feeling I had when I was younger. But also these songs to me are reserved in a particular time and place when I remember being very happy.
I'll play some old video games to get nostalgic about it, some of them really can't hold up, but it takes me back to places in my youth where I was happy.
Nostalgia ain't what it used to be.
Quote from: orthonorm on February 01, 2013, 12:08:57 PMNostalgia ain't what it used to be.Very Yogi Berraeseque...
People here are talking about sentimentality for an idealized past.
Quote from: orthonorm on February 01, 2013, 03:08:53 PMPeople here are talking about sentimentality for an idealized past.So what is it if it's not nostalgia?Is this a bad thing?
Is it bad to have old board games?No.
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I recently downloaded Bible Analyzer, and upon inspection, realized that I really needed the Strong's/Interlinear module(forgot what its called.) I installed the module, and now Bible Analyzer won't open. The main screen pops up, and it flashes some message about creating an index, and then the program shuts down.
I am unsure what to do, but now I am invested in making this software work, since I payed 5 bucks for the module. Oh, and I am an Ubuntu newb.
Running Lubuntu Desktop on top of 12.04


text:
Directory Listing
Offset fixes for 2.1.11-188.8.131.52-200708101800.
Adding the new version for yet another hardened-sources patchset.
Rebasing/Refreshing to apply to 2.1.11.
Initial release for 18.104.22.168.
Adjusting the rebased patch to apply to genpatches-base, since we are missing fbsplash.
Starting the 2.6.22 branch, based on genpatches-2.6/trunk/2.6.22.
Fixing yet again include/linux/sysctl.h to get the GRKERNSEC values right (my bad).
Another updated snapshot.
2.6.18 and 2.6.19 don't get stable patches anymore.
Tagging 2.6.21-5 to fix the screwup.
Fixing the grsecurity patch, yet again missed a single '};' screwing it all up.
Tagging 2.6.21-4.
Updated grsecurity patch, dating 22nd May 2007 (rev 18).
Tagging hardened-patches-2.6.20-5.
Fixing the reject w/ 188.8.131.52 on arch/sparc64/kernel/pci_iommu.c.
Tagging patchset for 2.6.21 (hardened-patches-2.6.21-3.extras).
Updating the patch once again, fixing the GRKERNSEC mess pipacs mentioned. Adjusting patch 4452 to the new CONFIG option.
Tagging hardened-patches-2.6.21-2.extras.
Yet another new grsecurity patch, hopefully fixing #177234.
Patchset for 2.6.21.
Updated grsecurity patch, header fixes.
This is 2.6.21 not 2.6.20 *shrug*!
Starting the 2.6.21 branch from genpatches-2.6/trunk/2.6.21 and hardened/2.6/trunk/2.6.20.
Tagging hardened-patches-2.6.20-4.
Removing the Index: header.
Yet another new patch, thanks to Brad.
Tagging patchset for hardened-sources-2.6.20-3.
Bumping the patchset once again, fixing my compile issues with the InstallCD config.
This should have been 2.6.20-2.
Removing 2.6.20-2.
Tagging patchset for 2.6.20-3.
Updated grsecurity snapshot (200704021831).
Adding an updated snapshot (200703271911), removing the old one (200703231034) and updating the pax_curr_ip-fixes for hunk alignment.
Patchset 2.6.20-1 for hardened-sources.
Offset updates for 2.1.10-2.6.20.
Rearranging the patches.
Adding Brad's updated patch.
Moving the branch, its no longer _pre like.
Tagging hardened-patches-2.6.18-5.
Removing the playtoy patch for now.
Adding UPSTREAM's fix for #170701 (thanks to Tony for pushing).
Offset/fuzz fixes.
Fixing a small reject in drivers/char/mem.c.
Bumping the patchset again, thanks to Kevin for the notice.
Releasing 2.6.19-7
Updates for 2.6.20.
Lets wait for a patch for 2.6.20.
Updates from genpatches-2.6/trunk.
Starting 2.6.20-pre for GRsecurity.
Fixing a reject in 4450_grsec-2.1.10-188.8.131.52-200702061822.patch.
Fixing the rejects in 4405_alpha-sysctl-uac.patch (due to missing KERN_FBSPLASH).
Updates from genpatches-2.6.
Reordering the patchset.
Purging the io-kmem patch for now.
Another patch bump.
Renaming the patch.
Moving 2.6.18 back into trunk.
Releasing 2.6.19-6
Small offset fixes.
Fixing the usual include/linux/sysctl.h reject, removing localversion-grsec from the patch.
Bumping the grsec patch, fixing the PaX expand_stack() vulnerability.
Releasing 2.6.19-5
Some offset fixes for pappy's playtoy.
*Sigh*, and all the fuzz because I didn't remove the old patch.
That should have gone before the release, *sigh*
Next time I should *really* test stuff _before_ creating a release (as in the patch is missing a ";" in drivers/char/mem.c).
Releasing 2.6.19-4
Moving 2.6.18 to historical, upstream doesn't release any more patches for it.
Another patch series update, grsecurity-2.1.10 is now the latest and greatest.
Releasing 2.6.19-3
Fixing build error due to additional '};' (#158107). Thanks to Petre Rodan <kaiowas at gentoo.org> for reporting.
Releasing 2.6.19-2
Removing the grsec_disabled patch, went into the grsecurity patch (thanks to Brad and Ned).
Another grsecurity bump (thanks to Ned).
Releasing 2.6.19-1
Fixing 4454_grsec-2.1.9-220.127.116.11-io-kmem-sysctl.patch in 2.6.18-4.
Removing pappy's warning, as it is fixed now.
Removing pappy's warning, as it is fixed now.
Releasing 2.6.18-4
Adding the missing includes, fixing #157409 (thanks to Attila Toth for the patch).
Adding the missing includes, fixing #157409 (thanks to Attila Toth for the patch).
Header updates, reordering.
Header updates, reordering.
Removing localversion-grsec, fixing include/linux/sysctl.h.
Making 4405 applying to 2.6.19.
Reordering the patchset.
Updating the grsecurity patch.
Syncing patches from genpatches.
Starting 2.6.19.
Moving old patchsets to historical/.
added warning to grsec io kmem patch about building bug
Adding subdirectory for the hardened-2.4 patchset.
Releasing 2.6.18-3
Adding credit to Ned Ludd and Peter S. Mazinger.
Adding credit to Ned and Peter Mazinger.
Releasing 2.6.18-2
It's a revert from said version, so treat it like that.
Adding Alexander's reworked patch for GRKERNSEC_IO / GRKERNSEC_KMEM.
Adding From: / Acked-by: tags.
Header updates.
Whitespace cleanup, fixing hunks with fuzz.
Reordering some of the patches.
Releasing 2.6.18-1
Fixing the patch header and the indention of the original line.
Reverting my last commit, splitting the warnings removal into a seperate patch.
Removing the warnings hunk from 4450_grsec-2.1.9-184.108.40.206-200611100917.patch; went into grsecurity but is too verbose.
Adding 2.6.18-hardened, with special thanks to Alexander Gabert (pappy) for his help.
Updating the grsecurity patch.
Reverting the squashfs-update as pointed out by dsd.
Updating the squashfs patch.
2.6.17-3 release
Updating the grsecurity patch version
Updating 4454_pax_curr_ip-fixes.patch, fixing a single hunk offset.
Updating grsec patch; Fixing some compile issues on alpha (thanks to ferdy).
removing, re-educated ;)
re-apply reslog fixes
2.6.17-2 release
Removing systrace
Removing reslogging which is already done by grsecurity
Releasing 2.6.17-1
Updating the .release file
Dropping the EXTRAVERSION from the patchname.
Hrm, missed a '0' after renaming the patch.
Updating the headers
Removing the localversion-grsec for real!
Fixing 4455_linux-2.6.16-reslog.patch to compile with 2.6.17 w/ grsec-2.1.9
Removing localversion-grsec from 4450_grsec-2.1.9-22.214.171.124-200608012135.patch; Fixing some leading/trainling whitespaces
Once again updating the grsec patch
Updating the grsecurity patch; Importing the new upstream version 200607261817
redo reslog
Hrm, we're at 2.6.17 now
Fixing remaining reject in 6001_systrace-2.6.16.patch, thanks dragonheart for the headsup
Bumping grsecurity patch; Fixing my booting issues
Renaming patch (this is 2.6.17) and making it apply against 2.6.17
New upstream grsec version against 18.104.22.168
Renaming patch (according to the 0000_README) and making it apply against 2.6.17
Updating to apply against 18.104.22.168
Removing 4100_libata-enable-atapi.patch, no longer needed in 2.6.17
Releasing 2.6.16-8
addition of reslog, a resource logging patch for grsec
Releasing 2.6.16-7
bump grsecurity patchset to 2.6.19 release.
Releasing 2.6.16-6
bump grsec snapshot
change release target
Releasing 2.6.14-7
prep hardened for initial 2.6.14 backport tests
added systrace patch
Releasing 2.6.16-5
prep hardeend for 188.8.131.52, atm you will need svn genpatches-base. Splits out i387 asm hunk, please test this. Reshuffle of patches
Releasing 2.6.16-4
Remove -grsec localversion, i somehow miss this every time.
fix .release
dorelease control file
Releasing 2.6.16-3
2.6.16-2 release
drop USERGROUP fixes, merged into upstream. Bump upstream GRSEC patch, Re-enable reiserfs sec labels - this should be OK now but requires some testing please.
Updating tag. I should really have just done this when I rolled it to the tree
Adding define CONFIG_PROC_USERGROUP fixes
updating tag - oops ;)
Missed the localversion file. Stupid thing
tagging (pre-)release
Initial Import of 2.6.16 tree
2.6.14-6 hardened release
bump to match 188.8.131.52 snapshot. Fixes policy recreaion bug. Adds >sys-apps/gradm-2.1.8-200602071945 depend
4906 fixes bug #121250 - _MODSTOP locking down other tunables. 4907 fixes bug #99413 - _PROC_MEMMAP RAND_FLAGS bug
2.6.14-5 release
adding tags dir & historical
initial import
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It's time once again for a recap of our weekly Wednesday night group ride, as recounted by Randy, our storytelling maestro. As always, the goal for the ride is the same: ride the 40 mile circuit at an average pace of 20 miles per hour, with a few county line sprints thrown in for bragging rights.
With the sartorial swagger of the rat pack, and perhaps a little bit of the prissiness of Miss J, eleven perfectly perky pedalers rolled out under a soundtrack of mariachi and the vapor of tequila shots. Pace was surprisingly listless but welcomed, as several of the regulars had ridden 106 miles in the heat at the Raven Rock Ramble on Sunday and didn't quite have the pep in the legs to bolt out of the gates at go-kart speed. Also thankful for the cruiser pace was O'Reilly, who despite getting blown out the back in less than a mile last week, was hanging in just off the back—not exactly working for the group, but taking credit for the coremetric optimization analytics sure to increase impression attribution and cross sell opportunity with the country kinfolk.
At such a conversational pace, chatter was abundant. Peterson talked 600lb squats; Rogers talked landscape architecture; Webster talked manscaping; Baker talked cupcakes; Overby talked Californication; Tommy V talked Riverdance; Gillis talked Dolce&Gabbana; McCarter talked Herradura Seleccion Suprema; Eichvalds muttered; O'Reilly yelled "wait for me"; Jones talked 2010 Focus Izalco Pro CP, one of the finest additions to the Performance platinum bike collection. Its solid handling, top-shelf gruppo and race-inspired graphics will have you dancing on the pedals up every climb and….whoa, sorry, my pimp fear got the best of me.
A first for the 40@20 group, we picked up two lone riders along the way: Graham, a UNC freshman, and Steve-O, McCarter's buddy and not of "Jackass" fame. Both were strong riders and we were all glad they weren't scared away after Peterson wrestled down an Aberdeen Angus, butchered enough beef to feed the population of Saxapahaw, and rejoined the group blood-fueled and ready for the first sprint.
Unlike last week, the sprint wind-up didn't begin until the last seven hundred meters before the line. Gillis broke first, with Peterson and Jones quick on his wheel. Overby tucked in next to Jones, and at 300 meters, threaded the needle like a 16 year old with a new Trans-Am trying to impress his blue-eye shadowed-AquaNet-teased-bangs-HubbaBubba-smackin girlfriend. Peterson gave chase but the filet mignon in his belly quickly brought him to an upright position. Jones kicked by and thought he might have a chance at second, but his hopes were dashed as he watched McCarter, Webster, and Rogers blow by. Overby was the winner by 6 bike lengths, with McCarter taking Webster by a lever.
At the crossroads, Peterson and Tommy V peeled off and went in search of O'Reilly. The remaining ten worked hard into Orange County and continued to ramp up the pace as we headed back south towards home. Rolling up next to The Kraken, we found O'Reilly engaged in a tense match of Cornhole with a fella who bore a striking resemblance to Leonard Smalls. Guess the coremetrics really worked.
Rounding on to Old Greensboro, we pacelined at close to 30 and kept charging all the way to Damascus. McCarter broke like he wanted to string out the group, but dialed it back quickly. En masse, we descended and broke hard right onto Meachum with Gillis leading the sprint. Once again, Overby shot through to the front and let it be known that in spite of his hairy legs, Kramden gut, and ironic socks, he is the most badass cyclist in the land. McCarter, Webster and Rogers were once again the chase group, with Jones desperately thumbing for a lasso in his jersey to rope em in. With 200 meters to go, Jones overtook Rogers and overlapped wheels with Webster and McCarter. Webster took down McCarter. Jones took down Webster. Overby could hear the creaking cleats of Jones's 10 year old shoes getting close, but knew he had the secret Nollie Heelflip Varial in his bag of tricks and took the line by a length over Jones. Webster took third.
Hard pedaling back in, Rogers again made the jump for the last sprint line. Overby and McCarter gave chase, but the Irishman was too much for them to handle, and he was whistling the Irish Spring jingle all the way home. The finishing six were ecstatic about the 21.3 average and if I had to guess our post ride beer of choice, this would be it:
Rogers—Beamish Irish Stout
Gillis—New Holland Mad Hatter IPA
Overby—Dark Lord Imperial Stout
McCarter—Gulden Draak (Dark Triple)
Webster—Mirror Pond Pale Ale
Jones—Green Flash IPA


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|Hanging out with the Genea-Peeps
Grand Island, Nebraska
photo by Beth Sparrow
When I arrived, I ran into several fellow genealogists I've met at previous conferences. I'm still a bit amazed at how easy it has been for me to feel connected and part of the genealogy community at these events. My usual shy nature has disappeared and I found myself table-hopping to get around to say hello to people I've met before and to finally meet several of my Facebook friends in person.
The first person I saw when I walked into the ballroom was Ruby Coleman. This was the first time we met in person, but we greeted each other with a bear hug as though we had been friends for years. Ruby is one of those special people to me. She was my first contact on Genealogywise and the first genealogist on Facebook to accept my friend request about two years ago. More about Ruby later!
|Judi Cook and Cindy Cochran of LLCGS
demonstrate the features
of the LLCGS web site
On Saturday, Nebraska Lt. Governor Rick Sheehy of Hastings welcomed our group to Grand Island and presented a proclamation from the Governor announcing that April 30 - May 6, 2012 is Nebraska's Genealogy Week. He shared some information about how genealogical research had impacted his family - that was a nice touch!
There is so much information to share about this year's conference that I'm spreading this out over several blog posts. Up next: featured speaker Laura Prescott.
|It's Official!
Nebraska's Genealogy Week
April 30 - May 6, 2012
Other posts in this series about the 2012 NSGS conference:
Arrows in Your Quiver - summary of presentations by Laura Prescott
2011 Nebraska Genealogist of the Year - Ruby Coleman
The link to this post is: http://longlostrelatives-smp.blogspot.com/2012/05/exhausted-and-exhilarated-2012-nsgs.html


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March 2, 2008
CAMBRIDGE, Mass. - In a back-and-forth affair, MIT emerged with a 30-19, 28-30, 30-23, 29-31, 19-17 victory over host Elms College in Saturday's non-conference match. The win raised the Engineers' ledger to 14-8 on the year.
Michael Demyttenaere paced MIT with a career-high 17 kills to go along with a .414 hitting percentage and six blocks. Ryan Dean tallied 57 assists, a career-best 26 digs, and four blocks as Praveen Pamidimukkala posted 14 kills and 12 digs. Kenneth Rosche notched 13 kills and a .321 hitting performance while Garrett Winther totaled 12 kills and five blocks. Matthew Ng and Scott Pollom contributed 12 digs and five blocks, respectively, to the Engineers' defensive efforts.


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I recently got a request to share some of my favorite recipes. I'm starting out with this one cause as soon as I'm not so lazy I'm heading to the store so I can make these.
Peanut Butter Marble Brownies
Candied Peanut Topping (optional):
1/4 to 3/4 cup peanuts, whole roasted (salted or unsalted)
maple syrup or any sugar (plus water if dry), enough to coat
1/2 cup peanut butter, any kind
1 tablespoon molasses
3/4 teaspoon almond extract
5 ounces semisweet or bittersweet chocolate, chips or chopped
2 ounces unsweetened chocolate, chopped
1/2 cup vegan margarine, cut into squares
3 tablespoons cocoa powder
1-1/4 cup sugar
3/4 cup tofu, any kind
2 teaspoons vanilla extract
1/2 cup unbleached all-purpose flour
1/2 cup whole wheat pastry flour
1 teaspoon baking powder
Candied Peanut Topping
1. Preheat oven to 350 degrees F. Line a baking sheet with parchment or silicone mat.
2. Toss peanuts with enough maple syrup to coat in a small bowl. If using dry sugar, add a little water to moisten and coat the peanuts. You need a moist sugar to get a nice crunchy caramelization on the nuts.
3. Spread the nuts on the baking sheet in 1 layer and bake until crunchy and candy-like, up to 20 minutes. Cool.
4. Chop candied peanuts and sprinkle evenly on prepared peanut butter brownie batter and proceed with baking the brownies.
1. Generously grease an 8″ square baking pan with vegetable oil. In a small bowl, combine the peanut butter, molasses, and almond extract and set aside.
2. Melt semi-sweet and unsweetened chocolates and vegan margarine in a double boiler or microwave on 50% power, stirring often. Whisk in the cocoa powder until smooth.
3. Puree the sugar, tofu, and vanilla together in a medium sized bowl (or add to after the fact depending on your method of puree!). Whisk in the melted chocolate-butter-cocoa mixture.
4. In a small bowl whisk together the all-purpose and wheat flours and baking powder. Add the dry ingredients to the wet ingredients and stir until just combined. Transfer the batter to the prepared pan and spread evenly to all corners.
5. Dollop the peanut butter mixture all over the brownie batter. Using a butter knife, drag the peanut butter through the batter up and down, rotate the pan and repeat. Or just swirl however you like. Bake on the middle rack for about 35 to 40 minutes or until a toothpick inserted in the middle comes out with a few moist crumbs attached. Let the brownies cool for about 2 hours in the pan. Now you can slice and serve. To get the 64 small squares, cut the brownies into 1″ squares.


text:
Emmanuel Frimpong has spoken of his delight at playing Premier League football again after making his debut for loan club Fulham.
The 21-year-old joined the Cottagers for the remainder of the season from Arsenal as he recovers from the cruciate ligament injury that ruled him out for the remainder of last term while enjoying a similar spell at Wolves.
Frimpong managed 64 minutes on his return to a starting line-up in an eager performance that earned himself a yellow card after a number of fouls on Norwich players, but the battling midfielder was pleased with his showing.
"I think it went well," he told Fulham's official website after the game.
"Before I came to Fulham I had hardly played any football - the last time I played in the Premier League was a year ago because of my injury."
The tough-tackling England youth international played six games for Championship side Charlton during the festive period, but says he feels more suited to life in the top division.
He added: "It was nice to play in the Premier League again and, hopefully, I'll get better with the more games that I play. I want to push on all the way until the end of the season."