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HARTSVILLE, S.C. – The Coker softball team lost a South Atlantic Conference doubleheader to Anderson University on Friday (Apr. 18).
Anderson scored the first two runs in game number one to take a 2-0 lead through four innings. Coker however, narrowed the Trojan lead to just one after Ashlee Ellen drove in Katelyn Szupello to make the score 2-1. The Cobras struggled to score in the last three innings, and Anderson would capture game one by a slight 2-1 margin.
Lauren Phillips (9-12) pitched a complete game for the Navy and Yellow, only giving up two runs on just four hits.
In game number two the bats began to heat up for Coker as they proceeded to score one run in the first, two in the second, and one more in the third to take a 4-3 lead. The Trojans would then go on to score four runs in the fourth and tack on another in the sixth, to eventually take the game by a final score of 8-5.
Leading the offensive charge for Coker was Szupello and Carley Bailey who each tallied a double, with Szupello adding two RBI to the stat sheet. Ashley Gallman also contributed two RBI, while Ellen added one of her own.
Logan Cox (1-7) would be marked with the loss, after giving up six runs on eight hits in 3.1 innings of work.
With the losses, the 2014 Coker softball season comes to an end. This years team graduated six seniors which included: Alex Cataldo, Clarrissa Suttle, Lauren Phillips, Sydney Weatherford, Stacy Burr, and Lauren Brailsford.


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South Korea, US begin naval drills amid North Korea nuclear threat
SEOUL, South Korea – South Korean and U.S. troops began naval drills Monday in a show of force partly directed at North Korea amid signs that Pyongyang will soon carry out a threat to conduct its third atomic test.
The region is also seeing a boost in diplomatic activity focused on North Korea's announcement last month that it will conduct a nuclear test to protest U.N. Security Council sanctions toughened after a December satellite launch that the U.S. and others say was a disguised test of banned missile technology.
Pyongyang's two previous nuclear tests, in 2006 and 2009, both occurred after it was slapped with increased sanctions for similar rocket launches. As it issued its most recent punishment, the Security Council ordered North Korea to refrain from a nuclear test or face "significant action."
North Korea's state media said Sunday that at a high-level Workers' Party meeting, leader Kim Jong Un issued "important" guidelines meant to bolster the army and protect national sovereignty. North Korea didn't elaborate, but Kim's guidelines likely refer to a nuclear test and suggest that Pyongyang appears to have completed formal procedural steps and is preparing to conduct a nuclear test soon, according to South Korean analyst Hong Hyun-ik.
"We assess that North Korea has almost finished preparations for conducting a nuclear test anytime and all that's left is North Korea making a political decision" to do so, Defense Ministry spokesman Kim Min-seok told reporters Monday.
The spokesman said he couldn't disclose further details because they would involve confidential intelligence affairs. Recent satellite photos showed North Korea may have been sealing the tunnel into a mountainside where a nuclear device could be exploded.
On Monday, South Korean and U.S. militaries kicked off three-day exercises off the Korean Peninsula's east coast that involve live-fire exercises, naval maneuvers and submarine detection drills.
South Korea's Joint Chiefs of Staff said the maneuvers are part of regular joint military training that the allies had scheduled before the latest nuclear tensions began. But the training, which involves a nuclear-powered American submarine, could still send a warning against possible North Korean provocation, a South Korean military official said, requesting anonymity because of department rules.
North Korean state media on Saturday described the drills as a joint exercise for a pre-emptive attack on the country. North Korea has said similar things when South Korea and the U.S. conducted other drills; the allies have repeatedly said they have no intention of attacking the North.
North Korea says U.S. hostility and the threat of American troops in South Korea are important reasons behind its nuclear drive. The U.S. stations about 28,500 troops in South Korea, a legacy of the 1950-53 Korean War, which ended with an armistice, not a peace treaty.
North Korea also has denounced sanctions over its rocket launches, saying it has the sovereign right to launch rockets to send satellites into orbit under a space development program.
North Korea's two previous nuclear tests are believed to have been explosions of plutonium devices, but experts say the North may use highly enriched uranium for its upcoming test. That is a worry to Washington and others because North Korea has plenty of uranium ore, and because uranium enrichment facilities are easier to hide than plutonium facilities are.
Diplomats are meeting to find ways to persuade North Korea to scrap its nuclear test plans. New U.S. Secretary of State John Kerry and his South Korean counterpart Kim Sung-hwan held a telephone conversation Sunday night and agreed to sternly deal with any possible nuclear provocation by North Korea, Seoul's Foreign Ministry said in a statement.
The chief nuclear envoys of South Korea and China met in Beijing on Monday and agreed that they would closely coordinate on ways to stop North Korea from conducting a nuclear test, according to Seoul's Foreign Ministry. China is North Korea's main ally and aid benefactor.
China has refused to say whether it was sending an envoy to North Korea or whether Pyongyang has informed Beijing about its plans for a nuclear test. China's Foreign Ministry on Monday reiterated Beijing's opposition to a test, though it did not mention North Korea by name.
"We call on all sides, under the current circumstances, to avoid taking measures which will heighten regional tensions. We hope all parties concerned can focus their efforts more on helping to ease tensions on the peninsula and throughout the region and jointly maintain peace and stability on the peninsula," Chinese Foreign Ministry spokeswoman Hua Chunying said at a daily media briefing in Beijing.

subset: commoncrawl


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I have heard of Geopathic Stress, but what is it?
Simply put, it is a mixture of detrimental or inherited human emotions, water veins and earth radiation that creates a subtle leaching of your life force, which eventually leads to many different health problems within individual people and their families.
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Phil Collins in concert at Groupama Stadium
English singer-musician Phil Collins will be coming to Lyon next year as part of his European tour. at The Groupama Stadium on June 4, 2019, for a unique date in France.
Mark Knopfler on tour in France in 2019!
He will be in France in the cities of Nimes, Lyon, Strasbourg, Toulouse or Floirac before a concert event at the AccorHotels Arena in Paris on June 17.
Muse revealed three concerts in France
Muse gives three concerts events in France in July 2019. Rendezvous at the Stade de France, Marseille and Bordeaux.
Book your tickets online here !
Florence Foresti back on stage in 2019
Florence Foresti announces her new show "Florence Foresti epilogue" that she will play in Paris at Paradis Latin from November 5th to December 18th, 2018 and at Zénith de La Villette for a handful of performances scheduled from December 26 to 31, 2018.
The farewell tour Elton John will pass through France in June 2019
The superstar of British pop will play four times in France next year during his world tour farewell, in Paris, Bordeaux, Lille and Nimes.
Ed Sheeran back to France in 2019
Great news for Ed Sheeran's french fans! The singer continues his world tour "Divide Tour" and adds two dates of concerts in Lyon and Bordeaux in May 2019.
Metallica Stade de France 2019
Unique French stage will allow Metallica to give a concert at the Stade de France, Sunday, May 12, 2019 in Paris - (St Denis)
JAIN in concert in France
the dates of her highly anticipated French tour have just fallen. This will take place in 2019, a tour of Zenith and large halls that will begin on March 1 at Zenith Amiens. Twenty dates are planned in the hexagon until June with a stage scheduled March 20 at the Zenith of Paris.
Paul McCartney: concert in France in November
The former Beatles, whose new solo album will be released on September 7th, will perform at the Paris La Défense Arena in Nanterre on November 28th, 2018
Patrick Bruel Tour 2019
In 2019 Patrick Bruel returns on stage to his fans with a tour that will begin on February 12th, 2019.
Indochine: New dates
The 13 round of Indochina has just won three new dates: Nantes, Clermont-Ferrand and Paris (AccorHotel Arena) While the new album of Indochine 13 is one of the best sales of this year
Book your tickets online here !
Nicki Minaj in concert in Paris and Bordeaux
The Hip Hop stars Nicki Minaj and Future will be together on the stage of the AccorHotels Arena in Paris for a scheduled date on Thursday, March 7th, 2019 and March 9th at the Bordeaux Arena.
Orelsan: new dates
No rest for the brave, the indefatigable Orelsan continues his masterful tour until next December and adds a series of new dates
Book your tickets online here !
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text: Hi, I don't think it wrong. It still depends on which situation you are referring to. For example, if you are traveling in Paris, you can take a picture of Eiffel Tower.Then you came back home sweet home, turning on PC and uploading all photos through a USB devise. Oaky, you found yourself quite Monet in that photo( I mean if you have a chance to take a look at Monet's work, you will see the beauty of it if you stand at a distacne. Well, it's unpleasant for eyes if you insist on standing in front of it, say 50 centimeters from it.) So you probably wants to use Photoshop or PhotoImpact to make yourself look better. In this case, you can make a photograph.


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This item contains photo-realistic brochure mockup in trifold and bifold styles. You can easily replace the design by using smart-object feature (instruction include). You don't need to worry about placement, perspective, lighting, etc. All have done automatically.
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Justin Reamer
Justin Reamer [Richard Caldwell, John Malcomb, James Roberts, and Roran Copperfield] (2 October 1993 / Holland, Michigan)
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Brussels, 31st January 2007
Competition: Commission sector inquiry finds major competition barriers in retail banking
The European Commission has published the final report of its competition inquiry into the retail banking sector. The inquiry has found a number of competition concerns in the markets for payment cards, payment systems and retail banking products. Particular indicators are large variations in merchant and interchange fees for payment cards, barriers to entry in the markets for payment systems and credit registers, obstacles to customer mobility and product tying. Some market participants have already offered voluntary reforms following the publication of preliminary findings on payment cards in 2006 (see IP/06/496 and MEMO/06/164). The Commission will use its powers under the competition rules to tackle any serious abuses, working closely with national competition authorities. The outcome of the inquiry should boost retail banking competition in the run-up to the creation of the Single Euro Payment Area (SEPA).
Competition Commissioner Neelie Kroes said: "The inquiry has found widespread competition barriers which unnecessarily raise the cost of retail banking services for European firms and consumers. The Commission will make full use of its powers under competition law to tackle these barriers, in the market for payment cards and elsewhere when they result from anticompetitive behaviour."
Payment cards and payment systems
The European payment cards industry is large and provides the means for consumer payments with an overall value of €1 350 billion per year. Such payments generate an estimated €25 billion in fees annually for banks from EU firms. The Commission's inquiry found indications of several concerns:
After publication of the interim report on payment cards and systems, the Commission met banks in a number of Member States to discuss where self regulation could address competition concerns. This approach is yielding promising results. Good examples are Austria, Finland and Portugal, where market players have taken initial steps to address the Commission's concerns.
The European banking industry – with the full support of the Commission and the European Central Bank – is working to create a Single Euro Payments Area (SEPA) to improve efficiency and lower the cost of retail payments. The sector inquiry has highlighted several market barriers that should be addressed in the SEPA context.
Retail banking product markets
The EU retail banking industry generates €250-275 billion per year in gross income, equivalent to 2% of EU GDP. Markets are generally fragmented along national lines, divided by factors including competition barriers and regulatory, legal and cultural differences. The sector inquiry found indications of competition problems in several areas:
The sector inquiry opened in June
2005 (see IP/05/719).
Interim reports were published on payment cards in April 2006 (see IP/06/496)
and current accounts and related services in July 2006 (see IP/06/999).
For further information, see also: MEMO/07/40.
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Anti-obesity medication
Anti-obesity medication or weight loss drugs are all pharmacological agents that reduce or control weight. These drugs alter one of the fundamental processes of the human body, weight regulation, by altering either appetite, or absorption of calories.[1] The main treatment modalities for overweight and obese individuals remain dieting and physical exercise.
In the United States only one anti-obesity medication orlistat (Xenical) is currently approved by the FDA for long term use.[2][3] It reduces intestinal fat absorption by inhibiting pancreatic lipase. Rimonabant (Acomplia), a second drug, works via a specific blockade of the endocannabinoid system. It has been developed from the knowledge that cannabis smokers often experience hunger, which is often referred to as "the munchies". It had been approved in Europe for the treatment of obesity but has not received approval in the United States or Canada due to safety concerns.[4][5] The European Medicines Agency in October 2008 recommended the suspension of the sale of rimonabant as the risks seem to be greater than the benefits.[6] Sibutramine (Meridia), which acts in the brain to inhibit deactivation of the neurotransmitters, thereby decreasing appetite was withdrawn from the United States and Canadian markets in October 2010 due to cardiovascular concerns.[3][7]
Because of potential side effects, it is recommended that anti-obesity drugs only be prescribed for obesity where it is hoped that the benefits of the treatment outweigh its risks.[8][9]
- 1 Mechanisms of action
- 2 History
- 3 Contemporary anti-obesity drugs
- 4 Alternative medicine
- 5 Side effects
- 6 Limitations of current knowledge
- 7 Future developments
- 8 See also
- 9 References
- 10 Further reading
- 11 External links
Mechanisms of action
Current and potential anti-obesity drugs may operate through one or more of the following mechanisms:
- Appetite suppression-Catecholamines and their derivatives (such as phentermine and other amphetamine-based drugs) are the main tools used for this, although other classes of drugs such as anti-depressants and mood stabilizers have been anecdotally used for appetite suppression (see: bupropion and topiramate). Drugs blocking the cannabinoid receptors may be a future strategy for appetite suppression.[10]
- Increase of the body's metabolism.
- Interference with the body's ability to absorb specific nutrients in food. For example, Orlistat (also known as Xenical and Alli) blocks fat breakdown and thereby prevents fat absorption. The OTC fiber supplements glucomannan and guar gum have been used for the purpose of inhibiting digestion and lowering caloric absorption
Anorectics are primarily intended to suppress the appetite, but most of the drugs in this class also act as stimulants (e.g., dexedrine), and patients have abused drugs "off label" to suppress appetite (e.g. digoxin).
The first described attempts at producing weight loss are those of Soranus of Ephesus, a Greek physician, in the second century AD. He prescribed elixirs of laxatives and purgatives, as well as heat, massage, and exercise. This remained the mainstay of treatment for well over a thousand years. It was not until the 1920s and 1930s that new treatments began to appear. Based on its effectiveness for hypothyroidism, thyroid hormone became a popular treatment for obesity in euthyroid people. It had a modest effect but produced the symptoms of hyperthyroidism as a side effect, such as palpitations and difficulty sleeping. 2,4-Dinitrophenol (DNP) was introduced in 1933; this worked by uncoupling the biological process of oxidative phosphorylation in mitochondria, causing them to produce heat instead of ATP. The most significant side effect was a sensation of warmth, frequently with sweating. Overdose, although rare, lead to a rise in body temperature and, ultimately, fatal hyperthermia. By the end of 1938 DNP had fallen out of use because the FDA had become empowered to put pressure on manufacturers, who voluntarily withdrew it from the market.[11]
Amphetamines (marketed as Benzedrine) became popular for weight loss during the late 1930s. They worked primarily by suppressing appetite, and had other beneficial effects such as increased alertness. Use of amphetamines increased over the subsequent decades, including Obetrol and culminating in the "rainbow pill" regime. This was a combination of multiple pills, all thought to help with weight loss, taken throughout the day. Typical regimens included stimulants, such as amphetamines, as well as thyroid hormone, diuretics, digitalis, laxatives, and often a barbiturate to suppress the side effects of the stimulants. In 1967/1968 a number of deaths attributed to diet pills triggered a Senate investigation and the gradual implementation of greater restrictions on the market. This culminating in 1979 with the FDA banning the use of amphetamines, then the most effective of the diet drugs, in diet pills.[12]
Meanwhile, phentermine had been FDA approved in 1959 and fenfluramine in 1973. The two were no more popular than other drugs until in 1992 a researcher reported that when combined the two caused a 10% weight loss which was maintained for more than two years.[13] Fen-phen was born and rapidly became the most commonly prescribed diet medication. Dexfenfluramine (Redux) was developed in the mid-1990s as an alternative to fenfluramine with less side-effects, and received regulatory approval in 1996. However, this coincided with mounting evidence that the combination could cause valvular heart disease in up to 30% of those who had taken it, leading to withdrawal of Fen-phen and dexfenfluramine from the market in September 1997.[12]
Ephedra was removed from the US market in 2004 over concerns that it raises blood pressure and could lead to strokes and death.[14]
Contemporary anti-obesity drugs
Some patients find that diet and exercise is not a viable option; for these patients, anti-obesity drugs can be a last resort. Some prescription weight loss drugs are stimulants, which are recommended only for short-term use, and thus are of limited usefulness for extremely obese patients, who may need to reduce weight over months or years.[citation needed]
Orlistat (Xenical) reduces intestinal fat absorption by inhibiting pancreatic lipase. Some side-effects of using Orlistat include frequent, oily bowel movements (steatorrhea). But if fat in the diet is reduced, symptoms often improve. Originally available only by prescription, it was approved by the FDA for over-the-counter sale in February 2007.[15] On 26 May 2010, the U.S. Food and Drug Administration (FDA) has approved a revised label for Xenical to include new safety information about cases of severe liver injury that have been reported rarely with the use of this medication.[16] Of the 40 million users of Orlistat worldwide, 13 cases of severe liver damage have been reported.[17]
Lorcaserin (Belviq) was approved June 28, 2012 for obesity with other co-morbidities. The average weight loss by study participants was modest, but the most common side effects of the drug are considered benign.[citation needed]
An excerpt from the Bloom 1 Study conducted by Arena Pharmaceuticals and later submitted for FDA approval:
At the end of Year 1 of the BLOOM trial, using Intent-to-Treat with Last Observation Carried Forward analysis (ITT-LOCF), the proportion of patients achieving at least 5% body weight loss in the lorcaserin group (47.5%) was more than twice that achieved by the placebo group (20.3%). Nearly three times as many patients achieved at least 10% weight loss in the lorcaserin group (22.6%) than in the placebo group (7.7%). Lorcaserin patients who completed the first year of the trial according to the protocol lost an average of 8.2% of their baseline weight, or approximately 18 pounds, at the end of Year 1 as compared to approximately 7 pounds in the placebo group. In Year 2, patients who continued to take lorcaserin were significantly better able to maintain their Year 1 weight loss than those who were switched to placebo.
In Year 1, lorcaserin caused significant decreases in waist circumference, BMI, glycemic parameters, high-sensitivity C-reactive protein, and fibrinogen levels compared to placebo. Total cholesterol, LDL cholesterol and triglyceride levels at Year 1 were significantly lower in the lorcaserin group than in the placebo group. Lorcaserin did not increase heart rate or blood pressure; rather, heart rate, systolic blood pressure and diastolic blood pressure decreased slightly but significantly with lorcaserin treatment compared to placebo. Quality of life, measured by the Impact of Weight on Quality of Life-Lite questionnaire, improved in both treatment groups, with a greater improvement in the lorcaserin group than in the placebo group.
At the end of Year 1, 55.4% of patients in the lorcaserin group and 45.1% of patients in the placebo group remained enrolled in the study, and 7.1% and 6.7% of patients, respectively, discontinued the study due to an adverse event. Among the most frequent adverse events reported with lorcaserin were headache (18.0% vs. 11.0%, lorcaserin vs. placebo); dizziness (8.2% vs. 3.8%); and nausea (7.5% vs. 5.4%). The rates of serious adverse events were similar in both treatment groups. The rates of depression and the incidence of anxiety and suicidal thoughts were low in both treatment groups. Lorcaserin caused no significant increase compared to placebo in the incidence of new cardiac valvulopathy.
Sibutramine (Reductil or Meridia) is an anorectic or appetite suppressant, reducing the desire to eat. Sibutramine may increase blood pressure and may cause dry mouth, constipation, headache, and insomnia.
In the past, it was noted by the US that Meridia was a harmless drug for fighting obesity. The US District Court of the Northern District of Ohio rejected 113 cases complaining about the negative effects of the drug, stating that the clients lacked supporting facts and that the representatives involved were not qualified enough.[18]
Sibutramine has been withdrawn from the market in the United States,[19] the UK,[20] the EU,[21] Australia,[22] Canada,[23] Hong Kong[24] and Colombia.[25] Its risks (non-life-threatening myocardial infarction and stroke) have been shown to outweigh the benefits.[26]
Rimonabant (Acomplia) is a recently developed anti-obesity medication. It is a cannabinoid (CB1) receptor antagonist that acts centrally on the brain thus decreasing appetite.[27] It may also act peripherally by increasing thermogenesis and therefore increasing energy expenditure.[27]
Weight loss with Rimonabant however has not been shown to be greater than other available weight-loss medication.[27] Due to safety concerns, primarily psychiatric in nature, the drug has not received approval in the United States or Canada, either as an anti-obesity treatment or as a smoking-cessation drug.[citation needed]
Sanofi-Aventis has received approval to market Rimonabant as a prescription anti-obesity drug in the European Union, subject to some restrictions.[citation needed] However, in October 2008, the European Medicines Agency (EMEA) recommended that Acomplia no longer be available in UK.[citation needed] One month later, Sanofi-Aventis decided it would no longer study rimonabant for any indication.[clarification needed]
In people with Diabetes mellitus type 2, the drug metformin (Glucophage) can reduce weight.[28] Metformin limits the amount of glucose that is produced by the liver as well as increases muscle consumption of glucose.[29]
Exenatide (Byetta) is a long-acting analogue of the hormone GLP-1, which the intestines secrete in response to the presence of food. Among other effects, GLP-1 delays gastric emptying and promotes a feeling of satiety. Some obese people are deficient in GLP-1, and dieting reduces GLP-1 further.[30] Byetta is currently available as a treatment for Diabetes mellitus type 2. Some, but not all, patients find that they lose substantial weight when taking Byetta. Drawbacks of Byetta include that it must be injected subcutaneously twice daily, and that it causes severe nausea in some patients, especially when therapy is initiated. Byetta is recommended only for patients with Type 2 Diabetes. A somewhat similar drug, Symlin, is currently available for treating diabetes and is in testing for treating obesity in non-diabetics.[citation needed]
|This section does not cite any references or sources. (February 2015)
Other drugs
Other weight loss drugs have also been associated with medical complications, such as fatal pulmonary hypertension and heart valve damage due to Redux and Fen-phen, and hemorrhagic stroke due phenylpropanolamine.[31][32] Many of these substances are related to amphetamine.
Unresearched nonprescription products or programs for weight loss are heavily promoted by mail and print advertising and on the internet. The US Food and Drug Administration recommends caution with use of these products,[33] since many of the claims of safety and effectiveness are unsubstantiated.[34] Individuals with anorexia nervosa and some athletes try to control body weight with laxatives, diet pills or diuretic drugs, although these generally have no impact on body fat.[35] Products that work as a laxative can cause the blood's potassium level to drop, which may cause heart and/or muscle problems. Pyruvate is a popular product that may result in a small amount of weight loss. However, pyruvate, which is found in red apples, cheese, and red wine, has not been thoroughly studied and its weight loss potential has not been scientifically established.[36]
The combination of phentermine and topiramate, brand name Qsymia (formerly Qnexa) was approved by the U.S. FDA on July 17, 2012, as an obestity treatment complementary to a diet and exercise regimen.[37]
Alternative medicine
Some supplements and alternative medicine have insufficient evidence to support or oppose their use.[38]
|Side effects
|Conjugated linoleic acid
|Helps reduce obesity[39]
|ECA Stack
|weight loss; athletic performance[40]
|Modest short term weight loss; ineffective in long term[40]
|possible adverse effects on the mental, digestive, and nervous systems; heart palpitations[40]
Side effects
Some anti-obesity drugs can have severe, even, lethal side effects, fen-phen being a famous example. Fen-phen was reported through the FDA to cause abnormal echocardiograms, heart valve problems, and rare valvular diseases.[41] One of, if not the first, to sound alarms was Sir Arthur MacNalty, Chief Medical Officer (United Kingdom). As early as the 1930s, he warned against the use of dinitrophenol as an anti-obesity medication and the injudicious and/or medically unsupervised use of thyroid hormone to achieve weight reduction.[42][43] The side effects are often associated with the medication's mechanism of action. In general, stimulants carry a risk of high blood pressure, faster heart rate, palpitations, closed-angle glaucoma, drug addiction, restlessness, agitation, and insomnia.
Another drug, orlistat, blocks absorption of dietary fats, and as a result may cause oily spotting bowel movements (steatorrhea), oily stools, stomach pain, and flatulence.[44] A similar medication designed for patients with Type 2 diabetes is Acarbose; which partially blocks absorption of carbohydrates in the small intestine, and produces similar side effects including stomach pain and flatulence.[45]
Limitations of current knowledge
|This section does not cite any references or sources. (February 2015)
The limitation of drugs for obesity is that we do not fully understand the neural basis of appetite and how to modulate it. Appetite is clearly a very important instinct to promote survival. Arguably any drug that would abolish appetite may carry a high mortality risk and may be unsuitable for clinical use.
Because the human body uses various chemicals and hormones to protect its stores of fat (a reaction probably useful to our ancestors when food was scarce in the past,) there has not yet been found a 'silver bullet', or a way to completely circumvent this natural habit of protecting excess food stores. Because of this, anti-obesity drugs are not presently a practical long-term solution for people who are overweight.
In order to circumvent the number of feedback mechanisms that prevent most monotherapies from producing sustained large amounts of weight loss, it has been hypothesized that combinations of drugs may be more effective by targeting multiple pathways and possibly inhibiting feedback pathways that work to cause a plateau in weight loss. This was evidenced by the success of the combination of phentermine and fenfluramine or dexfenfluramine, popularly referred to phen-fen, in producing significant weight loss but fenfluramine and dexfenfluramine were pulled from the market due to safety fears regarding a potential link to heart valve damage. The damage was found to be a result of activity of fenfluramine and dexfenfluramine at the 5-HT2B serotonin receptor in heart valves. Newer combinations of SSRIs and phentermine, known as phenpro, have been used with equal efficiency as fenphen with no known heart valve damage due to lack of activity at this particular serotonin receptor due to SSRIs. There has been a recent resurgence in combination therapy clinical development with the development of 3 combinations: Qsymia (topiramate + phentermine), Empatic (bupropion + zonisamide) and Contrave (bupropion + naltrexone).
Future developments
Other classes of drugs in development include lipase inhibitors, similar to orlistat. Another lipase inhibitor, called GT 389-255, was being developed by Peptimmune[46] (licensed from Genzyme). This was a novel combination of an inhibitor and a polymer designed to bind the undigested triglycerides therefore allowing increased fat expulsion without side effects such as oily stools that occur with orlistat. The development stalled as Phase 1 trials were conducted in 2004 and there was no further human clinical development afterward. In 2011, Peptimmune filed for Chapter 7 Liquidation.[47]
Another potential long-term approach to anti-obesity medication is through the development of ribonucleic acid interference (RNAi). Animal studies have illustrated that the deletion of the RIP140 gene in mice by genetic knockdown results in the lack of fat accumulation, even when mice are fed a high fat diet.[48] Similarly, another nuclear hormone receptor co-repressor, SMRT, has demonstrated an opposing effect in genetically engineered mice. Dr. Russell Nofsinger and Dr. Ronald Evans of the Salk Institute showed that disruption of the molecular interaction between SMRT and their nuclear hormone receptor partners leads to increased adiposity and a decreased metabolic rate.[49] These studies suggest that new drugs targeting the molecular interaction between nuclear hormone receptors and their regulatory cofactors could provide a useful new category of therapeutic targets to be developed in an effort to control obesity.
Another approach is to induce a sense of satiety by occupying space in the gastric and intestinal cavities. One clinical trial involves a hydrogel (Gelesis) made of indigestible, food-grade materials.[50] Another pilot study uses pseudobezoars.[51]
Other drugs in clinical trials as of October 2009 include Cetilistat and TM38837.
See also
- ^ National Institute for Health and Clinical Excellence. Clinical guideline 43: Obesity: The prevention, identification, assessment and management of overweight and obesity in adults and children. London, 2006.
- ^ "WIN – Publication – Prescription Medications for the Treatment of Obesity". National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). National Institutes of Health. Archived from the original on 13 January 2009. Retrieved 14 January 2009.
- ^ a b "www.fda.gov".
- ^ "Anti-obesity drug no magic bullet". Canadian Broadcasting Corporation. 2 January 2007. Retrieved 19 September 2008.
- ^ "FDA Briefing Document NDA 21-888 Zimulti (rimonabant) Tablets, 20 mg Sanofi Aventis Advisory Committee" (PDF). Food and Drug Administration. 13 June 2007. Archived (PDF) from the original on 10 September 2008. Retrieved 19 September 2008.
- ^ "www.emea.europa.eu" (PDF).
- ^ "Abbott Laboratories Voluntarily Withdraws Weight-loss Drug Sibutramine (Meridia) from the Canadian Market – Health Canada Information Update 2010-10-08".
- ^ Snow V, Barry P, Fitterman N, Qaseem A, Weiss K (2005). "Pharmacologic and surgical management of obesity in primary care: a clinical practice guideline from the American College of Physicians". Ann. Intern. Med. 142 (7): 525–31. PMID 15809464. doi:10.7326/0003-4819-142-7-200504050-00011.
- ^ Cooke D, Bloom S (2006). "The obesity pipeline: current strategies in the development of anti-obesity drugs". Nature reviews. Drug discovery 5 (11): 919–31. PMID 17080028. doi:10.1038/nrd2136.
- ^ Bray, G. A. (1993). "Use and Abuse of Appetite-Suppressant Drugs in the Treatment of Obesity". Annals of Internal Medicine 119 (7, Pt. 2): 707–713. doi:10.7326/0003-4819-119-7_Part_2-199310011-00016.
- ^ Parascandola J (November 1974). "Dinitrophenol and bioenergetics: an historical perspective". Mol. Cell. Biochem. 5 (1–2): 69–77. PMID 4610359. doi:10.1007/BF01874175.
- ^ a b Pool, Robert (2001). Fat: Fighting the Obesity Epidemic. Oxford, UK: Oxford University Press. ISBN 0-19-511853-7.
- ^ Weintraub M (May 1992). "Long-term weight control: The National Heart, Lung, and Blood Institute funded multimodal intervention study". Clin. Pharmacol. Ther. 51 (5): 581–5. PMID 1445528.
- ^ Kolata,Gina (2007). Rethinking thin: The new science of weight loss – and the myths and realities of dieting. Picador. ISBN 0-312-42785-9.
- ^ [1]
- ^ http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm213038.htm
- ^ Aronne, L.J.; Powell, A.G.; Apovian, C.M. (2011). "Emerging pharmacotherapy for obesity". Expert Opinion on Emerging Drugs 16 (3): 587–96. PMID 21834735. doi:10.1517/14728214.2011.609168.
- ^ Obesity, Fitness & Wellness Week (14 August 2004). "Legal Issues; Court dismisses claims against anti-obesity medication". Retrieved 9 April 2012.
- ^ Rockoff, Jonathan D.; Dooren, Jennifer Corbett (8 October 2010). "Abbott Pulls Diet Drug Meridia Off US Shelves". The Wall Street Journal. Archived from the original on 11 October 2010. Retrieved 8 October 2010.
- ^ "Top obesity drug sibutramine being suspended". BBC News. 22 January 2010. Archived from the original on 25 January 2010. Retrieved 22 January 2010.
- ^ Invalid language code. Sibutramin-Vertrieb in der Europäischen Union ausgesetzt [2]. Abbott Laboratories in Germany. Press Release 2010-01-21. Retrieved 2010-01-27
- ^ "Sibutramine (brand name Reductil) Information – Australia". Abbott Laboratories. 2010. Archived from the original on 14 October 2010. Retrieved 8 October 2010.
- ^ Health Canada Endorsed Important Safety Information on MERIDIA (Sibutramine Hydrochloride Monohydrate): Subject: Voluntary withdrawal of Meridia (sibutramine) capsules from the Canadian market.
- ^ "De-registration of pharmaceutical products containing sibutramine" (Press release). info.gov in Hong Kong. 2 November 2010. Retrieved 8 November 2010.
- ^ "Top 10 Diet Pills That Work in 2014". TENMANIA. 2014. Retrieved April 15, 2014.
- ^ http://www.nice.org.uk/nicemedia/live/11000/30364/30364.pdf
- ^ a b c Akbas F, Gasteyger C, Sjödin A, Astrup A, Larsen TM (January 2009). "A critical review of the cannabinoid receptor as a drug target for obesity management". Obes Rev 10 (1): 58–67. PMID 18721231. doi:10.1111/j.1467-789X.2008.00520.x.
- ^ George A. Bray and Frank L. Greenway (1999). "Current and Potential Drugs for Treatment of Obesity: Table 19: Clinical trials with metformin for the treatment of obese diabetics". Endocrine Reviews 20 (6): 805–87. PMID 10605627. doi:10.1210/er.20.6.805. Retrieved 7 August 2006.
- ^ http://teacherlink.ed.usu.edu/nmsmithpages/Personal/Diabetes%20Care%20Reference%20Materials/Diabetes%20Medications-%20Metformin.pdf
- ^ de Luis DA, Gonzalez Sagrado M, Conde R, Aller R, Izaola O (2007). "Decreased basal levels of glucagon-like peptide-1 after weight loss in obese subjects". Ann. Nutr. Metab. 51 (2): 134–8. PMID 17536190. doi:10.1159/000103273.
- ^ Abenhaim L; Moride Y; Brenot F et al. (August 1996). "Appetite-suppressant drugs and the risk of primary pulmonary hypertension. International Primary Pulmonary Hypertension Study Group". N. Engl. J. Med. 335 (9): 609–16. PMID 8692238. doi:10.1056/NEJM199608293350901.
- ^ Alfred P. Fishman, MD (1999). "Aminorex to Fen/Phen: An Epidemic Foretold". Circulation 99 (1): 156–161. PMID 9884392. doi:10.1161/01.CIR.99.1.156. Retrieved 24 July 2006.
- ^ U.S. Food and Drug Administration: The Facts About Weight Loss Products and Programs
- ^ "Prepared Statement of the Federal Trade Commission on the Marketing of Dietary Supplements" (Press release). Committee on Governmental Affairs, United States Senate. 8 October 2002. Archived from the original on 25 August 2006. Retrieved 7 August 2006.
- ^ Martin M, Schlabach G, Shibinski K (1998). "The Use of Nonprescription Weight Loss Products Among Female Basketball, Softball, and Volleyball Athletes from NCAA Division I Institutions: Issues and Concerns". J Athl Train 33 (1): 41–44. PMC 1320374. PMID 16558483.
- ^ George A. Bray and Frank L. Greenway (1999). "Current and Potential Drugs for Treatment of Obesity: Postabsorptive modifiers of nutrient metabolism". Endocrine Reviews 20 (6): 805–87. PMID 10605627. doi:10.1210/er.20.6.805.
- ^ Salynn Boyles (2012-07-17). "FDA approves diet drug Qsymia : agency warns of increased risk for oral birth defects". WebMD., citing "FDA approves weight-management drug Qsymia" (Press release). U.S. Food and Drug Administration. 2012-07-17.
- ^ Lau DC, Douketis JD, Morrison KM, Hramiak IM, Sharma AM, Ur E (April 2007). "2006 Canadian clinical practice guidelines on the management and prevention of obesity in adults and children [summary]". CMAJ 176 (8): S1–13. PMC 1839777. PMID 17420481. doi:10.1503/cmaj.061409.
- ^ a b Onakpoya IJ, Posadzki PP, Watson LK, Davies LA, Ernst E (March 2012). "The efficacy of long-term conjugated linoleic acid (CLA) supplementation on body composition in overweight and obese individuals: a systematic review and meta-analysis of randomized clinical trials". Eur J Nutr (Systematic review) 51 (2): 127–34. PMID 21990002. doi:10.1007/s00394-011-0253-9.
- ^ a b c Shekelle PG, Hardy ML, Morton SC et al. (March 2003). "Efficacy and safety of ephedra and ephedrine for weight loss and athletic performance: a meta-analysis". JAMA 289 (12): 1537–45. PMID 12672771. doi:10.1001/jama.289.12.1537.
- ^ Bachorik, Lawrence. "FDA Announces Withdrawal Fenfluramine and Dexfenfluramine (Fen-Phen)". U.S. Food and Drug Administration. FDA. Retrieved 2014-01-27.
- ^ [3], Launceston, Tasmania, Australia, Examiner, Friday, January 21, 1938, p 14, which states in postscript "However, the sex which for many years injured its health by tight lacing is not likely to be deterred from slimming by such considerations, The dictates of fashion will be paramount." Sir Arthur was particularly concerned with the neurological side effects of the then popular practice of dosing with thyroid extract to lose weight and, also, use of the then much vaunted weight loss drug dinitrophenol, which his report found killed as many patients as it reduced in girth, as well as, the compromise of the malnourished's immune system and their consequent, often, inability to resist infectious diseases like the then endemic tuberculosis (archaic "epidemics of consumption").
- ^ See, also, [4], Sidney Morning Herald, Nov. 17, 1937, p 10.
- ^ Johnson, Kimball. "Alli: A Weight Loss Drug". WebMD. WebMD. Retrieved 2014-01-27.
- ^ "acarbose - oral, Precose". MedicineNet. MedicineNet. Retrieved 2014-01-27.
- ^ Peptimmune homepage
- ^ McBride, Ryan. "Genzyme-Spinout Peptimmune Files for Chapter 7 Liquidation". Xconomy Boston. Retrieved 5 September 2011.
- ^ Leonardsson G; Steel JH; Christian M; Pocock V et al. (2004). "Nuclear receptor corepressor RIP140 regulates fat accumulation". Proc. Natl. Acad. Sci. U.S.A. 101 (22): 8437–42. PMC 420412. PMID 15155905. doi:10.1073/pnas.0401013101.
- ^ Nofsinger RR, Li P, Hong SH, Jonker JW, Barish GD, Ying H, Cheng SY, Leblanc M, Xu W, Pei L, Kang YJ, Nelson M, Downes M, Yu RT, Olefsky JM, Lee CH, Evans RM. (2008). "SMRT repression of nuclear receptors controls the adipogenic set point and metabolic homeostasis". Proc. Natl. Acad. Sci. U.S.A. 105 (50): 20021–6. PMC 2598729. PMID 19066220. doi:10.1073/pnas.0811012105.
- ^ "Research Shows First-of-Its-Kind Hydrogel Decreases Obese Patients' Desire for Food", press release by the American Association of Clinical Endocrinologists, 22 April 2010 text
- ^ Mintchev MP, Deneva MG, Aminkov BI, Fattouche M, Yadid-Pecht O, Bray RC (1 February 2010). "Pilot study of temporary controllable gastric pseudobezoars for dynamic non-invasive gastric volume reduction". Physiol. Meas. 31 (2): 131–44. PMID 20009188. doi:10.1088/0967-3334/31/2/001.
Further reading
Boss, Olivier; Karl G. Hofbauer (2004). Pharmacotherapy of obesity: options and alternatives. Boca Raton: CRC Press. ISBN 0-415-30321-4.
External links


text:
Blackwater defense: Iraqi police removed evidence
WASHINGTON (AP) — A defense attorney told a federal jury on Wednesday that Iraqi national police removed evidence that would prove Blackwater security guards were being fired on by insurgents, prompting the guards to return fire in shootings that killed or wounded over 30 Iraqi civilians.
The assertion came in closing arguments at the guards' trial that began in June. Prosecutor Anthony Asuncion told the federal jury that the Blackwater guards unleashed a hail of gunfire that left "bloody, bullet-riddled corpses" at Nisoor Square in downtown Baghdad seven years ago.
Lawyers for the defendants said the guards acted in self-defense in firing their weapons, that there is ample evidence they were fired upon by insurgents, but that additional evidence supporting their case had disappeared.
"We will never know the extent to which Iraqi national police scrubbed the scene" of evidence that Blackwater guards were fired on, said Brian Heberlig, who is representing former Blackwater guard Paul Slough.
Declaring that there was no incoming gunfire, Asuncion said the four defendants "took something that didn't belong to them" — the lives of human beings and the health of others who are still suffering from their wounds from the Sept. 16, 2007 shootings.
The jurors' job "is a search for truth" in the wake of violently shattered lives, Asuncion said.
The U.S. government brought charges against the defendants in 14 of the deaths and 18 of the non-fatal shootings.
One defendant, Nicholas Slatten, faces a first-degree murder charge. Defendants Slough, Dustin Heard and Evan Liberty are charged with voluntary manslaughter, attempted manslaughter and gun charges.
Slatten could be sentenced to life imprisonment if convicted. The others face mandatory minimum sentences of 30 years in prison if convicted of the gun charge and one other count.
In his closing argument, Asuncion disputed the self-defense assertions.
One of the witnesses in the trial, Blackwater team leader Jimmy Watson, testified that on that day in Nisoor Square, he heard the incoming "pop" of what sounded like AK-47 rounds shortly before Slatten fired his weapon twice at the start of the violence.
Watson's testimony supports the idea that there was incoming gunfire because AK-47s were the type of weapons used by insurgents.
Asuncion discounted Watson's testimony, with the prosecutor saying that Watson had never said anything previously about incoming gunfire under questioning by investigators.
It's different when your former associates "are looking you in the eye" in an open courtroom, Asuncion said in suggesting that Watson had made up the story to help his former Blackwater colleagues.
During the trial, the defense team has made much of photos of eight AK-47 shell casings that were taken near Nisoor Square the same day as the shootings, suggesting they were evidence of insurgents firing on the Blackwater convoy.
"Shell casings on the streets of Baghdad are about as common as seashells at the beach," Asuncion told the jury. "They are scattered all over the place. The defense desperately wants you to believe" the shell casings are significant.


text:
The steep cuts in public funding for the nation's top public research universities are taking a toll, and not just on the pocketbooks of students who attend them.
A new report released Tuesday by the National Science Board makes the case that a 20 percent average funding cut between 2002 and 2010 (after accounting for inflation and increased enrollment) has threatened the mission of the country's 101 research universities.
It's an important point that often gets lost in the dog fight over increasing tuition and a diminishing pool of public money.
And in Colorado, it's even worse than the national average with institutions seeing a 48 percent decrease in state support. The state ranks 50th in per-student funding.
It's distressing, and should be yet another indicator that the state needs to find a way to better fund higher education to keep tuition increases in check and so that important research and the training of budding scientists can continue to flourish at these institutions.


text:
Aaron Lejzerowicz
Born: March 23, 1919
Zdzieciol, Poland
Aaron was one of four children born to a Jewish family in the northeastern Polish town of Zdzieciol. His father was a shoemaker and, along with a business partner, he also ran a shoe store in the town. Aaron attended a private Jewish school, where he studied the Polish language and history as well as Jewish history and Hebrew.
1933-39: On September 1, 1939, Germany invaded Poland. Three weeks later, Poland was partitioned between Germany and the Soviet Union [under the German-Soviet Pact]. We felt lucky. Zdzieciol was in the eastern part occupied by the Soviets so we didn't see any Germans in 1939. We'd heard stories about the German treatment of Jews and were elated to see the Soviets. Father advised us that two trades needed during war were tailoring and shoemaking.
1940-44: In June 1941 Germany invaded the USSR. In early 1942 the Germans set up a ghetto in Zdzieciol, and on August 6 decided to liquidate it. At 4 a.m. we heard people running; Germans and drunk Lithuanians surrounded the town. We were marched to a cemetery and ordered to lie face down. Professions were called out: "Carpenters! Blacksmiths!" When shoemakers were called I raised my hand, never lifting my head. A soldier hit me with a rifle and ordered me up. I was among those deported to a work camp. The rest were shot.
Later, Aaron escaped and joined the Soviet partisans. Conscripted into the Soviet army in July 1944, he was in Germany when the war ended. He immigrated to the United States in 1947.


text:
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text:
The Dolphins are conducting meetings with players at their facility next week, with several players already scheduled to fly in Monday for Tuesday visits.
Count Illinois running back Mikel Leshoure prominently among the players the Dolphins will be meeting with soon. The team is looking for replacements for either Ronnie Brown or Ricky Williams or both and Leshoure's performance last season -- 1,697 rushing yards and 17 TDs -- suggest he's as solid a possibility as anyone.
So what should the Dolphins look for when they search for a running back?
They need to find a guy who can square his shoulders and get up field quickly. They should find someone who can absorb hits with some sort of subtlety to where it seems as if defenders are always just missing. This is important because backs that take full-on hits all the time don't last very long or get hurt a lot. Quickness is a trait you want from a running back, one that is more important than speed, quite frankly.
You probably think I'm crazy for typing that last sentence, right? After all, look at Chris Johnson. The man is a lightning bolt and that speed is intoxicating. Yes, but Johnson is also quick. Speed on it own gives you a track man. NFL teams want football players.
Speed is not so valuable in the absence of instinct.
Consider that Ronnie Brown came out of Auburn and to Miami as the No. 2 overall selectionin 2005. He ran a 4.4 in the 40 at the Indianapolis Combine. But how many 70 yard touchdown runs has that led to with the Dolphins?
Meanwhile, a guy such as Emmitt Smith could barely crack 4.6 in the 40-yard dash. And yes, he ran behind a dominant offensive line. But when he got past the second level, I don't rightly recall him getting caught from behind by cornerbacks or safeties that could run much faster. He had quickness. He had instincts. It's important.
One player that I had not heard about until this week was brought to my attention by a great personnel man I sometimes converse with and always respect. Check out Maryland running back Da'Rel Scott.
He's 5-11 and 211 pounds. His stats at Maryland as a junior were good but not great. He gained 708 yards. He's projected to be a 5th or 6th round pick. But this personnel man really likes Scott. Says he had very nice quickness to go with his 4.4 speed.
And, of course, he gets square quickly.
Look, I don't claim to be a draft guru. Frankly anyone in the media that claims to be a draft guru without actually having NFL experience is something of a poser. But what I do is talk to people who are legitimate personnel people, who have been in draft rooms and have true expertise and experience.
Those guys actually picked players. And I, in turn, pick their brains and pass along to you as much information as they allow me to do. Scott is a guy that has been suggested to me as a value pick in the fifth or sixth round but perhaps someone takes him a bit sooner.
We'll see how it turns out.
As they say in Boston, follow me on twitta.


text:
This pledge closed about 5 years ago
A group of pet-loving criminal lawyers has launched an online campaign to flush out whoever killed and mutilated a family's pet dog then dumped it on a front lawn.
Portia, a 6-year-old fox terrier, vanished from her home in Karaka, south of Auckland, 10 days ago.
A week later, her body was found on the lawn of its owner.
The dog had been skinned, a paw and both ears were missing, and her shoulder was broken.
The SPCA says the attack could be connected to the mutilation of two pet rabbits in nearby Papakura in May.
Now a group of Auckland lawyers have built a website,www.deaddogrewardfund.co.nz, and are asking pet-lovers to go online and make pledges toward a reward, which they will pay out for information that leads to a conviction.
Please continue reading the story:
Link: http://www.stuff.co.nz/national/crime/9000129/Online-hunt-for-killer-of-pet-dog
What you can do to help>>


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text:
Chronic Wasting Disease wasn't found in any of the nearly 2,100 wild deer samples tested from York and Adams counties last year, but the fatal deer disease could continue to affect the local hunter's experience for seasons to come.
Hunters in the two-county, 600-square-mile management area were mandated to take their harvests to testing stations last year after the disease turned up in two deer at an Adams farm, one of which was once kept at a Dover Township deer farm.
The Pennsylvania Game Commission last week announced that three hunter-killed wild deer, part of a broader testing initiative, were positive for the disease. Two were from Blair County; the other was from Bedford County.
Though the disease wasn't found in York's wild deer population, Game Commission procedure calls for continuing the management area restrictions for five years, said Barry Leonard, information and education supervisor for the south-central region.
"Normally we would do it for another four years, but since it was found in free-ranging deer elsewhere in the state ... there will probably be other measures taken," he said. "Whether we continue (testing) on a mandatory or a voluntary basis is to be decided."
Fines issued: Leonard said it's possible the captive deer in York and Adams went on breeding exchanges at deer farms outside the area, and that's how they caught a disease that hasn't manifested in the wild population locally.
It's possible the "more strict" regulations could be moved to the areas where the disease was found in the wild, but officials are still managing the commission's response for the fall season, he said. There could be adjustments to the timing of the season or mandatory check-in sites for Blair and Bedford counties.
The new regulations in York and Adams didn't appear to affect the turnout for hunting season, he said, as the number of deer harvested seemed to be in keeping with pervious years' trends in the area.
There were "dozens" of citations filed against people who failed to comply with the mandated testing, said Richard Palmer, director of the Bureau of Wildlife Protection.
Officials won't have a final number of fines, which range from $100 to $200, calculated until June.
Some people violated the rules because they were loyal to specific meat processors, while others "just didn't want to do it," he said.
Wants fewer rules: Hunter Jeff Georg of Manchester Township is among those hoping for less restriction in York County.
The 43-year-old father said he's been a hunter for about 23 years, and he wanted to teach his sons the lessons that can be found out in the woods: no instant gratification, no video games.
But while son Cole McNaughton might be one of few 9-year-olds who can say he's seen the sun rise over a quiet woods, the story of the day he bagged his first deer was tainted by the CWD restrictions, Georg said.
"He has a bigger memory of the difficulties surrounding the harvest of the deer than he does the joy of his first deer," Georg said.
Cole shot a button buck just before dark, but the two were turned away from a state-approved butcher because he was only accepting past customers.
"So we drove another 20 miles out of the way to get to the (state) testing station, where we were told they weren't going to test it because it was too young," Georg said. "It was 9 o'clock until we got home that evening. That wasn't the joyful experience that it could've been."
Precautions: Leonard said officials hope to make the testing process as smooth as possible, but most hunters have understood the necessity for and the scope of the operation being undertaken by the commission.
Officials can only hope to manage the spread of the disease, for which there is no treatment or vaccine, he said.
People are discouraged from eating meat that hasn't been tested or that tested positive, though the Centers for Disease Control has said there have been no cases of people becoming ill from meat since the disease was first found in Colorado in 1967, Leonard said.
There's also no evidence of the disease jumping to any other species, he said.
In addition to social "licking" of deer, the disease is in part spread in the wild through the same intuitive rituals that propagate the species, he said.Females secrete hormones that bucks can detect and, "in his excited state," the bucks will "lick up" the ground where a female's urine or feces might've been, he said.People who see an obviously sick deer are encouraged to the call the commission at 814-643-1831, he said.
Symptoms include a dropped head, excessive thirst, down ears, and lack of fear of humans.
"Toward the end, there's very little muscle tone to the animal, hence the term wasting disease," he said. "If they see deer acting strange like that, they should give a call and let us know."
Wasting disease in wild deer could bring tweaks to hunting regulations
Chronic Wasting Disease wasn't found in any of the nearly 2,100 wild deer samples tested from York and Adams counties last year, but the fatal deer disease could continue to affect the local hunter's experience for seasons to come.


text:
Opinion: Noam Chomsky Meets His Match
WSJ assistant books editor Sohrab Ahmari on a revealing tussle between Noam Chomsky and the academic left who subscribe to Slovenian philosopher Slavoj Žižek. Photos: Associated Press
This transcript has been automatically generated and may not be 100% accurate.
... I ... welcome back to Opinion Journal I'm Mary Kissel academic food fights in our universities are fine ... but they're also revealing because they expose what ... passes for thought these days in our ivory towers ... Wall Street Journal Assistant books editor so ever Mari is here with the story ... so what's in my ceiling list and leftist known Shumsky up to the States ... well he's he's retired from his job and now one other things he's doing is he's the ... throwing food ... and another prominent ... leftist academic team the Savoy Zhi Asia ... aam he didn't interview Chomsky in ... December ... of last year ... we basically says I don't know this you know French theory stuff that passes for humanity's not isn't the University they just use ... fancy words and basically they don't say anything in the inshore it's just a bunch of nonsense ... wrapped and ... to me the complex vocabulary a bunch of nonsense practice complex ... vocabulary of the half what Chomsky stinking him self a mean this is kind of thing kettle calling the pot black ... it's exactly right because after that the interview of the can publicize this summer ... JJ came back and said you know what ... I said you know he Chomsky who emphasizes how we should be empirical and working based on facts ... well he's actually ... very very often wrong on the facts ... aam and so my take is basically that they're both right ... they're both right about this one thing ... namely each other ... Chomsky is in fact often actually Ron ... Gray in nineteen seventy seven on the Cambodian genocide was going on ... Chomsky wrote this famous essay where he said ... aam you know the the atrocities are elected and you know at most another number that counts in the hundreds of thousands ... anyhoo it's all the U S this fall when in fact a year one point seven million ... Cambodians ... died during that period ... so he's he's often wrong factory ... but that doesn't mean it she said is that is any better now our viewers might not know who she checked in students a little bit of a sketch of his background Wednesday shortly he's a he's a Slovenian philosopher who combined cycle analysis which Marxism ... and you know he he let's let's use pop culture for example he ... he said ... Jurassic Park and it is actually a chamber drama about the trauma of fatherhood and it's a very typical issues it can ... and say in a pm ... inside and what's ... in Facebook's M ... he's very entertaining he loves to use in a dirty jokes references to the Matrix the sense and so forth ... to push ... and it was actually a very totalitarian and and that ... you know he's very proud of ... joking about how he likes enough Stalin how he is a picture Stalin in the bedroom some of this is a peek at me with these two are actually ... very well known in corn respected figures in the Ivory tower into the rock stars and these are the biggest folks ... in in academic ... circles and in ... the humanities ... and be what it tells you is that that that ... the tenure system ... and then ... it you know that that that that is a political bet me ... that the center of gravity in the Academy ... is still far off ... that to a from anything that you know the American people or people in the West generally what Watt are stinkers to be thinking about ... but maybe that's always been so I don't know ... I think it has always been something it's probably getting worse Wall Street Journal Assistant books under server market ... thanks in advance and


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Punk shows are always more visceral when you're hurting. You're feeling a mix of emotions, and despite how cheesy it sounds (no pun intended), sometimes the best way to let them out is to thrash around in a mosh pit and sing your heart out. Saturday night, during The Coathangers' headlining set at the Highline,Read more…
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The 2012 ChinaJoy Cosplay extravaganza was especially extravagant in this case, as an entire stage is decked out with League of Legends cosplayers.
It's not just the quantity that's impressive, it's the quality of said quantity. Also of note? The prolonged pose-holding. These cosplayers are serious.
A few weeks back I made a concerted effort to get into this game. It's going... OK. I'm not quite at the stage where I travel to China in costume though.
Unbelievable League of Legends Cosplay Show [Fashionably Geek]


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CRESTVIEW � The Hub City is the No. 4 college town in the country, according to the American Institute for Economic Research, which ranked areas with less than 250,000 residents.
CRESTVIEW � The Hub City is the No. 4 college town in the country, according to the American Institute for Economic Research, which ranked areas with less than 250,000 residents.
Business Insider credited the city with having an average income of $41,852 per capita and a college student concentration of 82.3 per 1,000 people.
See a brochure of the American Institute for Business Research's Top 20 College Towns, among other rankings>>
Northwest Florida State College and Embry-Riddle Aeronautical University's nearby campuses also helped Crestview get within the top five of the 20-town list.
Ithaca, N.Y. was No. 1; Ames, Iowa, No.2; State College, Penn., No. 3; and Iowa City, Iowa was No. 5.
Former state senator Durell Peaden said the city earning the honor is "impressive."
"It's very remarkable for our small country town," Peaden said. "It shows that we are definitely on the right track."
In addition to bringing the Florida International University physician assistant program to Crestview, Peaden is responsible for the Florida Agriculture and Mathematics University's Pharmacy School in downtown Crestview.
With satellites, the pharmacy school and Embry-Riddle allow college students to interact with main campuses in larger cities.
This type of technology puts Crestview and Okaloosa County "ahead of the curve," Peaden said. "With this type of technology, you don't have to go to Gainesville or Tallahassee; you got the prime source here."
Although there are several Embry-Riddle campuses in Okaloosa County, including Hurlburt Field and Eglin Air Force Base, Crestview's campus holds a certain standing, Embry-Riddle representative Ron Garriga said.
"Crestview has the highest percentage of projected enrollment out of all the 150 (Embry-Riddle) satellite campuses, both domestically and abroad," he said.
The success is due to the good working relationship between the university and area aeronautical-related employers, which provide financial assistance to Embry-Riddle students, Garriga said.
Peaden said he hopes to add more collegiate opportunities to Crestview soon. He said giving residents more opportunities for higher education is beneficial to city growth.
"I believe economic development should be focused on education," he said.
Contact News Bulletin Staff Writer Matthew Brown at 850-682-6524 or email@example.com. Follow him on Twitter @cnbMatthew.


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Celebrate Creativity Kids Hour: Creating Music with GarageBand
Monday 28 January
1:15 pm – 2:15 pm
Apple Garden City Perth
Go to My Reservations to cancel your reservation
This Kids Hour celebrates music by teaching kids how to create exciting tunes and beats using GarageBand on iPad. First, we'll cover rhythm basics and kids will get hands-on by creating their own drum beats. Then we'll show them how to use Live Loops to make their very own rock, hip-hop or EDM track. Kids can bring their iPad or we'll provide one. Recommended for ages 6 to 12.
Garden City
Booragoon, WA 6154


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Brazil worried about stadium gentrification
The Brazilian government is worried ordinary fans could be priced out of the country's modernised stadiums in an unwanted legacy from hosting the 2014 World Cup.
Brazil is building two brand new stadiums and remodelling another 10 which will leave the country with a glut of all-seater, state-of-the-art arenas once next year's tournament is finished.
It will be a new experience for many Brazilian fans who for years have had to put up with dilapidated arenas, dubious catering and overflowing toilets.
The worry is that many of those who provided the throbbing atmosphere at top matches will no longer be able to afford to go to games as administrators look to gentrify the football-going public to increase income.
"To have socially exclusive stadiums as a result of the World Cup investments is not the legacy we want," deputy sports minister Luis Fernandes told Reuters in an interview.
"The government is very concerned with this issue and it has to be addressed very seriously. I think we could have a gentrification of the stadiums.
"Some stadium administrators are quite explicit in saying that, to be economically feasible, they would have to shift the type of attendance at games," he added.
"It would change from one where what predominates is the so-called D and E class, to one where there will be a heavy predominance of what they call class A and B spectators who will not only buy the tickets but will also consume in the stadium.
"But if you want to shift the social origin of the spectators so you can have people that can afford to buy other merchandise and food besides tickets, that could be a negative side effect."
Until recently, there has been almost nothing to buy inside Brazilian stadiums apart from rudimentary fast food and soft drinks. Supporters often prefer to buy counterfeit merchandise from unlicensed street vendors, known as camelos, in front of the stadium.
Nine of Brazil's 12 World Cup stadiums are owned by the governments of the respective states and will be handed over to private administrators who will hope to make money from selling merchandise inside.
"Football had and has a very central role in building national identity in Brazil," added Fernandes. "So we are very concerned with that aspect and will be dealing with it in terms of national and state legislation."
A similar phenomenon has already taken place in England where stadiums have improved vastly over the past 20 years, but working-class fans have been priced out and replaced by middle-class ones.
However, while the shift in England, was built on the back of growing popularity for football, attendances at many Brazilian games are shrinking with an average of 13,000 for last year's national championship first division.
Fans of Cruzeiro have already noticed the difference. Cheapest tickets for some of the team's matches have cost 60 Reais ($29.87) since the re-opening of Belo Horizonte's Mineirao stadium.
Meanwhile, cheapest tickets for the re-opening the Castelao stadium in Fortaleza cost 50 Reais for a double bill of matches in the local state championship, more than at many European first division clubs.
Fernandes pointed out that football had such a strong influence


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Kevin Jonas Gossip
Kevin Jonas gossip, latest news, photos, and video.
Priyanka Jonas brothers double date
Hewitt / SplashNews.com, Ricky Vigil M/ Getty Images
In 2006, teenage girls everywhere would have squealed at the chance to go on a double date with the Jonas Brothers. I worked at a music station at the height of the Jonas craze and there were literal lineups around the block to get a chance to breathe the same air as Nick, Joe, and Kevin, I guess. In 2006, Sophie Turner was 10 years old so basically a zygote and Priyanka Chopra was already starring in blockbuster Bollywood films. Full Story
Heads up Kristen Bell: Corporate sponsoring the birth
Slaven Vlasic/ Getty
The oldest Jonas's wife had a child yesterday. He was live-tweeting the labour and then told his followers to follow the Dreft Twitter account for the official sponsored birth announcement…!!!!! Look! The logo is on the photo! Full Story
Broken Down Jonas Brothers
Pacific Coast News
The Jonas Brothers were supposed to go on tour in two days. It was just announced this afternoon that they're tapping out and PEOPLE reports that it's because they pretty much hate each other right now. No, not in those words, but their publicist is calling it a "deep rift" over "creative differences". Full Story
Danielle Jonas Catches The Snitch
Wenn, Dave Kotinsky/ Getty
Danielle Jonas is pregnant and now we've got some problems. The first problem is how much do I have to explain about who Danielle Jonas is? She's at a particularly weird point in the celebrity life cycle where some people (ME!) know enough about her to make fun of her decorating taste and yet lots of other people (although probably not many regular readers of this blog) are going to be like "who? It's pronounced 'Danielle Fishele'. Full Story
Lessons in Sport by Joe and Kevin Jonas
Written by Jacek You can always count on the Jonas brothers for some photo gold, especially when it comes to their attempts at athleticism. I'm no gossip guru and probably have a pretty selective memory when it comes to most celebrity subjects, but it seems to me that 80% of the time the Jonas brothers are photographed they're attempting to be athletic in some way. Full Story
2 minutes of amazingness
And so much f-cking cringe. Ew! But I've watched this 3 times. And since Kevin Jonas chose to provide his wedding video (totally free, right?) to Access Hollywood, this sh-t is fair game. Especially when it's such a wonderful gift. Right off the top, note the fist pump. My friend Scott said it's more like a Cheerleader Pump. Full Story
Vagina Virgin wedding sale Part 2
Way to commemorate a private occasion. By selling exclusive wedding photos to People Magazine in a paid package that probably included a picture of the honeymoon – how's that for keeping some things to yourself? Last week it was Kevin Jonas and his "princess" in a fake New York castle with a Disney ceremony. Full Story
Fake castles, glass slippers, and Vagina Virgins
One of the Jonas Brothers got married recently. According to Michelle's Boy Band Theory, it was the irrelevant one. Or the least attractive one. What? It's not like you weren't thinking it. Full Story
He had to keep his shirt on
The Jonas Brothers made a surprise appearance today at the Air Canada Centre for We Day. You can imagine the screaming. Yesterday the Vagina Virgins participated at CIBC Run For The Cure. Miraculously, Joe kept his shirt on. Those in Yorkville would find this particularly surprising because during the film festival, a shirtless Joe could oft be seen running around Toronto's busiest neighbourhood bare chested getting in a fitness fix despite the ubiquitous presence of paps hoping to get shots of George Clooney and the Mighty Opes. Full Story
Vagina Virgin Hair
So the Jonas Brothers played in New York today and I looked at these photos and I was making ew gross that's nasty faces because what the f-ck is this hair and why are they wearing it? And then Michelle and Jen B had to jump in all reasonable and mature, explaining that they'd take this natural curl, as lame as it is, over the straight iron look of LipGloss BlenderLegs MoistFace Zac Efron and, yeah, I couldn't disagree. Full Story
They were in London today promoting something – maybe a movie? Yes, probably. The movie that did not fare very well at the North American box office. Apparently their tv show wasn't a huge success either. Not great news for a "band" about to release their fourth album Lines, Vines, and Trying Times. Full Story


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Diving into Honors challenges
Student-athletes compete in the top level of JMU academics
By Meaghan MacDonald ('13)
Up Close
Camilla Czulada ('16)
Communication science disorders
Swimming and diving
- Participated in four events in four different meets during her rookie season
- Placed first in the 200 freestyle in the CAA Pod meet
- Placed third in the 50 freestyle in dual meets against Villanova, West Virginia, UMBC and Rider
Embracing the highest values of sportsmanship and competition has benefits that extend far beyond the playing field. JMU student-athletes are supported in maintaining a balance between academic scholarship and varsity team demands.
JMU faculty members encourage student-athletes to balance competition with respect, victory with honor and contest with scholarship, and to channel the character-building power of athletics performance into a force for positive change.
JMU President Jonathan R. Alger says that during his "Why Madison?" Presidential Listening Tour many student-athletes told him that they chose JMU because of the academic program. "It is reassuring how much Madison student-athletes truly want to excel as students—in academics and organizations outside of their sport—despite the challenges of a rigorous athletics schedule," Alger says. "Their priorities are in the right place and align with the JMU philosophy that intercollegiate athletics are integrated into the overall educational mission."
A number of JMU's varsity athletes are taking their academic winning spirit to the next level as members of the JMU Honors Program. To maintain status in the JMU Honors Program, a student must maintain a 3.25 GPA and take at least one honors-level course each semester.
Rising sophomore Camilla Czulada ('16) of Sinking Spring, Pa., talked to Madison magazine about the challenges and joys of being an honors student-athlete.
"I didn't apply the first semester because I didn't know a lot about the Honors Program when I was recruited," she says. "I was accepted before my second semester and for me, this was a great way to get involved. ... I had already developed good study habits and time-management skills before I added honors courses to my academic workload."
While Czulada acknowledges the challenges of making a commitment to both academics and sports on such a demanding level, she's proud of her accomplishments. "Although I sacrifice a lot to be able to succeed both in the classroom and in the pool, I wouldn't take back a minute of it. Everything has been so worth it because I know how hard I had to work to get where I am. I have also proven to myself that I can attain my goals if I work hard.
Published: Monday, November 4, 2013
Last Updated: Thursday, October 20, 2016


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Whoops, Wrong Target Demographic …
"MySpace is clearly leading the social-networking category with the largest, most engaged audience as compared to all other social networks," Jack Flanagan, executive vice president of comScore Media Metrix, said that earlier this month in a press release noting that MySpace is outperforming all other social-networking sites. Little did he know that a few weeks later, MySpace would reveal that it's outperforming its rivals in other ways as well. Specifically, in the growth and engagement among its registered sex-offender community.
Myspace.com revealed yesterday that it had located and deleted the profiles of 29,000 registered sex offenders from its site–29,000, enough to populate an entire city with sexual predators. It's also more than four times the number the company reported earlier this year.
"The exploding epidemic of sex-offender profiles on MySpace–29,000 and counting–screams for action," Connecticut Attorney General Richard Blumenthal said in a statement. "Our information demands reveal shocking new skyrocketing numbers of convicted sex-offender profiles on MySpace. Each of these 29,000 separate profiles reflects a potential predator willing and able to exploit a child."
Good thing Hemu Nigam's CV includes stints as director of consumer-security outreach and child-safe computing at Microsoft, as well as a federal prosecutor for child-exploitation cases for the U.S. Justice Department, because he's clearly in his element in his new gig as MySpace's chief security officer.


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Latest scandal again tarnishes state politicians
If the public knew how $10,000 influenced legislation at the state Capitol, "They'd burn the place down," bragged Ray Soucy, the bald, meaty corrections officer at the center of a pay-to-kill-bills scheme.
Caught on tape in the FBI sting operation that shattered the congressional dreams of Speaker of the House Chris Donovan, D-Meriden, the blunt-talking, aggressive Soucy sounds like a character out of a political version of "The Sopranos" cable television series.
While using his political and union connections -- and contributions -- for access, the recordings show how he aggressively pushed lawmakers in an ultimately failed attempt to defeat a proposal that would cost Soucy's business associates money.
It's a sad truth that Connecticut residents -- thanks to corruption scandals involving former Republican Gov. John Rowland, ex-state Sen. Ernie Newton, D-Bridgeport, and others -- already know some elected officials are, in Soucy's words, "whores" for sale.
"Briefly, it will deepen (voters') suspicion of all politicians, but they don't have far to go," said Rich Hanley, a professor of journalism at Quinnipiac University.
"Folks generally have this idea that money is the lubricant of life and in politics it's the actual blood of life. ... They understand these characters (like Soucy) exist in the political process and he's just emerging from the soup."
Other observers say that ethics and public campaign finance reforms after the Rowland and Newton era have made the Soucys of the state the aberration, where public money is available for high-profile state elections, including for governor and the General Assembly.
But last week, at least in a U.S. District Courtroom in New Haven, that was hard to believe.
"Politics is about the Benjamins," Soucy told an FBI informant in evidence presented at trial last week that embroiled Donovan, a Meriden Democrat, current House Majority Leader Joseph Aresimowicz, D-Berlin, and House Minority Leader Lawrence F. Cafero Jr., R-Norwalk.
Soucy is a key witness called in the federal prosecution of Robert Braddock, finance director for Donovan's failed 2012 bid to win the 5th Congressional District seat won by Elizabeth Esty, of Cheshire, who beat Donovan in last summer's primary.
Braddock is the only one of eight defendants, Soucy included, who did not plead guilty after an FBI investigation uncovered a conspiracy by owners of tobacco stores -- friends of Soucy -- to try to pay off key lawmakers in exchange for promises to kill legislation to impose license fees and use taxes on roll-your-own tobacco machines.
Braddock's trial began Monday. Soucy, a union official and active Democrat, has, in live testimony and through recorded and written messages obtained by the FBI, painted a bleak picture of an easily bought state government.
In one conversation with an FBI informant, Soucy talked about how during a legislative session lawmakers "Can't accept checks for their campaigns ... so you have to go green."
"A local politician is a $100 whore, a state politician is a $1,000 whore and a national politician is a $10,000 whore," Soucy said.
In another excerpt Soucy compared politicians to organized crime.
"We're not dealing with the mob (but) it's a close second," he said.
And here's Soucy telling a smoke shop operator to prepare more contributions: "I'm gonna need people to write checks again ... $7,500 to Donovan, $2,500 to the Connecticut State Democratic Committee. And I've got five grand coming to Cafero and three grand to A to Z" (a nickname for Aresimowicz).
Footage captured by a miniature video camera worn by an FBI informant was shown in court of Soucy and Cafero bending to a refrigerator in the latter's legislative office. Soucy testified he had placed an envelope containing $5,000 in cash inside.
He said the money was quickly returned to him so he then converted it into five $1,000 checks to Cafero's political action committees. Cafero returned all the money to the FBI following last year's arrests and last week said Soucy never put money in his refrigerator.
Donovan and Cafero have repeatedly denied any wrongdoing and have not been charged with any crimes. Aresimowicz has not been charged, but declined comment this week because he is listed as a potential witness.
License charges on roll-your-own machines, as well as taxes on customers using the machines, were eventually approved by the General Assembly last year, in action after the adjournment of the regular legislative session.
Once a liberal star seemingly with an all-but-sure lock on the 5th District seat that Chris Murphy was leaving to run for U.S. Senate, Donovan was unable to overcome the scandal.
While Soucy was taking the stand last week, the Legislature was meeting almost daily, debating and voting on legislation as the clock ticked down to the final day of the 2013 session on June 5.
"Sure it's a distraction -- how could it not be," said Donovan's successor, Speaker Brendan Sharkey, D-Hamden. "But so far it hasn't affected the ability of the Legislature to conduct its business."
State Rep. Jack Hennessy, D-Bridgeport, has spent the session pushing conflict-of-interest legislation to prevent public employees from serving on a city council, as is the case in Bridgeport.
"I think the perception is this guy (Soucy) is just an ignorant blowhard wannabe and the integrity of the Legislature is not really being implicated by this," Hennessy said. "Consider the source. It really isn't reflective of the legislative process. That's my point of view. It's a guy that wanted to find some kind of relevancy where he had none."
But others are not so certain the public will have the same impression.
"Whenever situations develop as this has and the allegations start coming out, it always will have a corrosive effect on the public trust and confidence," said former state Rep. Christopher Caruso, D-Bridgeport. "It just underscores money has a negative influence on American politics."
As a chairman of the legislature's government administration and elections committee, Caruso was involved in passing reforms as a result of prior high-profile corruption scandals in Hartford.
Rowland served a 10-month prison sentence for accepting gifts from state contractors.
Newton's 17-year career in the Legislature ended when he was sentenced to a five-year prison term in 2006 for taking a $5,000 bribe, diverting $40,682 in campaign contributions to himself and filing false income tax returns.
Kim Hynes, senior organizer for good-government group Common Cause Connecticut, said it is frustrating to watch the latest political corruption scandal unfold. She sees Soucy as a throwback to the age before the state's landmark 2005 campaign finance laws.
"We've seen a huge difference in the Capitol since clean elections have taken place," she said. "It's a much more level playing field up there in terms of lobbyists (and) normal people who didn't used to get the ear of legislators as easily as they do now."
She and Caruso said there is still much to be done when it comes to cleaning up federal elections.
"It gives rise to seriously consider the enactment of a federal public financing system to block influence peddling, to block this type of conduct or behavior," Caruso said. The public financing component in Connecticut limits the amount individuals can contribute to $100. When candidates reach fundraising targets, they are eligible for primary and general election support.
State Senate Minority Leader John McKinney, R-Fairfield, last year had called on Donovan to step down as House speaker.
McKinney said he was not certain how the details of the trial were playing outside the Capitol walls.
"We were in session Tuesday, Wednesday, Thursday voting most of the day and night," he said. "But look, any time these types of scandals happen it can only hurt the reputation of all elected officials. It's the reason I called on the speaker to step down and was a lone voice."
McKinney said ethics and campaign laws could perhaps be strengthened even further, but at the end of the day, such matters come down to individual character. "If two or more people want to come up with a scheme to get around those laws ... there sadly will always be a way," he said.
Staff Writers Ken Dixon and Michael Mayko contributed to this report.


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8:00 pm
Outdoor Idaho "Hometown Ski Hills" Community ski hills are scattered throughout Idaho, each with its own "field of dreams" story to tell. We profile three of them - Bogus Basin near Boise; Little Ski Hill by McCall; and Pomerelle near Albion - to learn what makes each of these ski areas unique.G
8:30 pm
This American Land "Fiddler Crabs, Disappearing Chincoteague, California Desert, Hurricane Sleuth" Between their digging and mating rituals, people find fiddler crabs amusing. But these little crustaceans have a big impact on their environment and scientists are still trying to understand just where these animals fit into the coastal ecosystem.G
9:00 pm
Midsomer Murders "Who Killed Cock Robin, Part 2" Although all suspicions are aimed toward ex-con Stockard, Barnaby discovers there are others who have vengeful motives involving the victim. Part 1 of 2G
10:00 pm
Vera (Apt) "A Certain Samaritan" DCI Vera Stanhope investigates the murder of 29-year-old Niall Coulter while his closest associates are intent on obscuring the truth. While coping with revelations from her own past, Vera sifts through evidence of the grief, love, and addiction that characterized Niall's life.G
11:30 pm
Charlie Rose NULL


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Recap: Staggering Royals surrender to Nationals
KANSAS CITY, Mo. (AP) As tough as it was to handle, the weak-hitting Kansas City Royals hoped Friday night's loss to Washington might at least ignite a slumbering offense.
But no such luck.
Facing Washington right-hander Jordan Zimmermann on Saturday night, they fell right back into an offensive funk.
They managed nine hits.
But all were singles as the Nationals handed the Royals a seventh straight loss with a 7-2 decision.
"I haven't figured it out, and I'm not going to figure it out," Royals manager Ned Yost said. "We're going to get a game where we get some hits and win a game and get it going."
After a 19-5 surge gave fans hope for an end to a 27-year playoff drought, the Royals have lost seven in a row and 10 of 12.
"It's frustrating," left fielder Alex Gordon said. "I don't like losing streaks and I don't like losing streaks after we've been playing so well. We're professionals. We'll keep playing and grinding."
Do the Royals have another good streak left?
"This team has another good run in it," Yost said. "It sure does."
Rebounding from one of his worst career outings, Zimmermann went 7 2/3 innings, allowing two runs and eight hits.
He struck out seven and walked just one. After George Kottaras singled with two out in the fourth, Zimmermann retired 11 straight until Emilio Bonifacio walked with one out in the eighth.
"I had four pitches working and when I have that going, it's usually a fun night to be out there," he said. "And the offense got some runs early and allowed me to settle in."
Ian Desmond hit his 18th home run as the Nationals won their fifth in a row, all on the road. The Nationals have won 11 of 15 overall while the Royals have been staggering.
"He has four above-average pitches and everything he throws dives into lefties," K.C.'s Eric Hosmer said of Zimmermann. "I can see why he's so tough to hit."
The victory tied Zimmermann with Adam Wainwright of the Cardinals for the NL lead in wins.
"He had a tremendous slider, pitched with conviction and kept his fastball down," Yost said. "He had us off balance all night."
Wade Davis (6-10) allowed seven runs and eight hits in six innings, including Desmond's two-run home run in the sixth. He walked three and struck out four.
The Nationals, who scored seven runs in the fourth inning of a come-from-behind 11-10 victory on Friday, scored four in the same inning against Davis.
Ryan Zimmerman walked leading off and sped to third on a single by Bryce Harper, who had an RBI single in the first.
Wilson Ramos hit a sacrifice fly, Tyler Moore delivered an RBI double and Chad Tracy brought in two more runs with a bloop single.
"We're putting good at-bats together, seeing the ball well, pitching well, playing good defense," Desmond said. "It's just been a matter of time. We're starting to get hot. Guys are starting to see the ball better."
The Royals bunched three singles off Zimmermann in the third, including Hosmer's run-scoring hit into left-center.
Fernando Abad relieved Zimmermann with two out and one on in the eighth and allowed an RBI single to Mike Moustakas before David Lough struck out with the bases loaded to end the inning.
With the victory, the Nationals guaranteed a winning interleague record for the third straight season.
NOTES: Washington outfielder Jayson Werth, who hit a two-run home run Friday night, sat out with an infection between the toes of his right foot. He was hoping to play on Sunday. … In a salute to the Negro leagues, the Royals wore the uniform of the Kansas City Monarchs while the Nationals dressed as the Washington Homestead Grays, a rematch of the 1942 Negro Leagues World Series. … Alex Gordon recorded his league-leading 11th outfield assist when he threw out Ryan Zimmerman in the first inning trying to stretch a single into a double.