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NIH has received new funds for Fiscal Years 2009 and 2010 as part of the American Recovery & Reinvestment Act of 2009 (Recovery Act), Pub. L. No. 111-5. The NIH has designated at least $200 million in FYs 2009-2010 for a new initiative called the NIH Challenge Grants in Health and Science Research.
This new program will support research on topic areas that address specific scientific and health research challenges in biomedical and behavioral research that would benefit from significant 2-year jumpstart funds.
The NIH has identified a range of Challenge Areas that focus on specific knowledge gaps, scientific opportunities, new technologies, data generation, or research methods that would benefit from an influx of funds to quickly advance the area in significant ways. Each NIH Institute, Center, and Office has selected specific Challenge Topics within the broad Challenge Areas related to its mission. The research in these Challenge Areas should have a high impact in biomedical or behavioral science and/or public health.
NIH anticipates funding 200 or more grants, each of up to $1 million in total costs, pending the number and quality of applications and availability of funds. In addition, Recovery Act funds allocated to NIH specifically for comparative effectiveness research (CER) may be available to support additional grants. Projects receiving these funds will need to meet this definition of CER: "a rigorous evaluation of the impact of different options that are available for treating a given medical condition for a particular set of patients. Such a study may compare similar treatments, such as competing drugs, or it may analyze very different approaches, such as surgery and drug therapy." Such research may include the development and use of clinical registries, clinical data networks, and other forms of electronic health data that can be used to generate or obtain outcomes data as they apply to CER.
The application due date is April 27, 2009.
Note: Those marked with an asterisk (*) are the highest priority topics; however, applicants may apply to any of the topics.
(01) Behavior, Behavioral Change, and Prevention
(02) Bioethics
02-HG-101* Informed consent and data access policies. The creation of large databases that include genomic information on individual participants, coupled with the move to universal electronic medical records, makes it increasingly possible to identify individual research participants in databases, despite efforts to "de-identify" their data, and potentially to unearth an individual's private medical information. Research is urgently needed to address the implications of this for recruitment, informed consent, and data access policies in biomedical research. Contact: Dr. Jean McEwen, 301-402-4997, firstname.lastname@example.com
02-HG-102 Direct to Consumer (DTC) Personal Genomics--Ethical, Legal and Social Implications Research. Direct-to-consumer marketing of targeted genetic scans for particular disease mutations and for ancestry-informative markers has been available for several years, and a growing number of companies now offer direct-to-consumer (DTC) personalized genomic services based on more comprehensive genomic analyses. The emergence of these DTC genetic testing services raises many issues: Are such services a generally positive advance that empowers the public, or are they premature? What is the potential for consumers to be educated, helped, confused, or even misled by these services? How do those who use these services react to the information they receive? How do health care providers deal with this information? Research is needed to address these and other issues related to DTC marketing of genetic tests. HHGRI Contact: Dr. Jean McEwen, 301-402-4997, firstname.lastname@example.com.
02-HG-103 Natural selection in the human genome--Ethical, Legal and Social Implications Research. The characterization of signatures of recent positive selection in genes that are of adaptive significance in humans can have great medical relevance, by helping to identify functionally significant variants that play a role in health and disease. However, research on recent positive selection in the human genome has methodological challenges and can have significant ethical and social implications. The results of studies that attribute differences in allele frequencies between populations to recent positive natural selection may challenge past understandings about human history and the way that we think about differences. Where the frequencies differ substantially between populations (as defined by ancestral geography), these findings may affect the way we think about differences (both real and perceived) between people from various ancestral backgrounds. Research is needed on the ethical, legal and social issues associated with the way that natural selection research is designed, conducted, and the results communicated to the public. NHGRI Contact: Dr. Jean McEwen, 301-402-4997, firstname.lastname@example.com.
02-HG-104 Uncovering Genomic Contributions to Human Traits and Behaviors: Ethical, Legal and Social Implications Research. Many studies are underway that explore the genetic contribution to non-disease attributes (e.g., the aging process, diurnal rhythms) and to behavioral traits (e.g., cognition, personality traits). These types of studies raise ethical issues similar to other types of genetic studies, but can raise heightened or in some cases unique concerns, relating especially to such issues as: definitions of "normalcy"; the potential for genetic determinism (and its societal implications); and the potential for stigmatization of individuals or groups. Research is needed that addresses these and other implications of research in this area. Contact: Dr. Jean McEwen, 301-402-4997, firstname.lastname@example.com.
02-HG-105 Genotype-Tissue Expression (GTEx): Ethical, Legal and Social Implications Research. The GTEx project is an NIH Roadmap Initiative (http://nihroadmap.nih.gov/GTEx/) to create a public resource that will help reveal the role of genetic variation in human gene expression and regulation. This project is designed to collect and analyze multiple human tissues from diverse populations in a variety of settings, including organ transplant settings, medical examiner offices, low-post mortem interval autopsy programs and surgical settings. The phenotypic and genomic information derived from these samples will be placed in a database and made widely available for research use. Research is needed that addresses the ethical, legal and social issues related to the collection and use of this information. Contact: Dr. Joy Boyer, 301-402-4997, email@example.com.
02-RR-101* Recontact Issues in Genotype and Genome-Wide Association Studies. Genotype and genome-wide association studies create challenging re-contact issues if subjects are later to be asked to return for clinical research including phenotyping. Applicants would propose 2-year awards for pilot programs that would be implemented at 3 or more affiliated sites to develop and apply IRB guidelines that addressed ethical barriers (e.g., re-contacting) in genotype - phenotype studies. This idea is submitted through NCRR on account of the ethics work underway at the Clinical and Translational Science Awards (CTSAs) and, if accepted, would be developed with NHGRI's ELSI Division. NCRR Contact: Andrea Sawczuk, 301-435-0792, firstname.lastname@example.com; NHGRI Contact: Dr. Jean McEwen, 301-402-4997, firstname.lastname@example.com
02-OD(OSP)-101* Unique Ethical Issues Posed by Emerging Technologies. Advances in biotechnology and biomedical science raise novel ethical, legal, and social issues. Research in this area is needed to understand the unique ethical concerns related to emerging technologies (e.g. biotechnology, tissue engineering, nanomedicine, and synthetic biology). These include issues such as dual use research, privacy, safety, intellectual property, commercialization and conflict of interest, among others. Research is also needed to assess how these novel issues are addressed under current oversight and regulatory structures and identify where there may be gaps and/or need for revised or new oversight approaches. OD(OSP) Contact: Abigail Rives, 301-594-1976, email@example.com; NHGRI Contact: Dr. Joy Boyer, 301-402-4997, email@example.com.
02-OD(OSP)-102* Ethical Issues in Health Disparities and Access to Participation in Research. Research is needed to assess the under-representation in biomedical and clinical research of U.S. minority populations, underserved populations, and populations who may be vulnerable to coercion or undue influence, to identify barriers to participation in research and to develop approaches for overcoming them. Additionally, studies are needed to assess the impact and ethical considerations of conducting biomedical and clinical research internationally in resource-limited countries. OD(OSP) Contact: Abigail Rives, 301-594-1976, email@example.com; NHGRI Contact: Dr. Jean McEwen, 301-402-4997, email@example.com.
02-OD(OSP)-104* Ethical Issues in the Translation of Genetic Knowledge to Clinical Practice. Genetics and genomics have great promise for the development of personalized medicine, yet the ethical, legal and social implications of both the research and application of genetic and genomic knowledge and technology are far reaching. Studies are needed to better understand the factors that influence the translation of genetic information to improved human health and the associated ethical issues. Examples of studies include those to address ethical issues related to broad sharing and use of new genetic information and technologies for research to improve human health, human subjects protection in genetic and genomic research, the identifiability of genetic/genomic information and how our understanding of identifiability is evolving, return of research results and incidental findings to subjects, alternative models of informed consent for broad data sharing for research, and the impact of intellectual property (IP) issues on development of new technologies. OD(OSP) Contact: Abigail Rives, 301-594-1976, firstname.lastname@example.com;NHGRI Contact: Dr. Elizabeth Thomson, 301-402-4997, email@example.com.
02-OD(OSP)-105* Ethical Issues Raised by the Blurring between Treatment and Research. The distinction between clinical practice and research is growing less clear, a trend that may be more pronounced with respect to genetic information and medical records research. Studies are needed to better understand the ethical issues associated with this trend. Examples of studies include those to identify how this blurring in roles affects traditional human subjects protections, including, for example, essential practices such as informed consent, conceptions of the doctor/patient and investigator/subject relationship, and privacy protections. OD(OSP) Contact: Abigail Rives, 301-594-1976, email@example.com; NHGRI Contact: Dr. Elizabeth Thomson, 301-402-4997, firstname.lastname@example.com.
(03) Biomarker Discovery and Validation
(04) Clinical Research
(05) Comparative Effectiveness Research (CER)
(06) Enabling Technologies
06-HG-101* New computational and statistical methods for the analysis of large data sets from next-generation sequencing technologies. The introduction of new methods for DNA sequencing has opened new avenues, including large-scale sequencing studies, metagenomics, transcriptomics, genetic network analysis, and determination of the relationship of sequence variation and phenotypes to disease, to address heretofore unapproachable problems in biomedical research. However, since the large amounts (terabases) of data generated overwhelm existing computational resources and analytic methods, urgent action is needed to enable the translation of this rich new source of genomic information into medical benefit. Contact: Dr. Lisa Brooks, 301-496-7531, email@example.com.
06-HG-102* Technologies for obtaining genomic, proteomic, and metabolomic data from individual viable cells in complex tissues. Most existing technologies can only measure the properties of a population of cells and not the properties of individual cells. Technologies that are able to use one or a small number of cells are needed to generate data to understand the molecular phenotype, or state, of a particular cell type and the role it plays in tissue and organ function in health and disease. Contact: Dr. Brad Ozenberger, 301-496-7531, email@example.com.
06-HG-103* Methods to sequence highly variable, repeat-rich regions of complex genomes. Variants in complex genomic regions, e.g. the MHC region, have implications for infectious and autoimmune diseases, yet these and many other highly repetitive and highly variable loci are often poorly represented in sequence assemblies using data from newer "short read" sequencing platforms, and are too expensive to sequence with older, Sanger-based platforms. Technology development is needed to sequence and assemble these regions efficiently and accurately or they will continue to be unexamined in large medical genomics studies. Contact: Dr. Adam Felsenfeld, 301-496-7531, firstname.lastname@example.com.
06-HG-104 New technology and resources for personalized medicine. To make personalized medicine a reality requires new technologies and resources, such as rapid point-of-care genotyping methods and more effective ways to use genetic testing results in conjunction with electronic medical records. Research on the effects that the utilization of such resources has on health costs and outcomes is also urgently needed to achieve the full integration of personalized medicine into current health care systems. NHGRI contact: Dr. Ebony Bookman, 919-541-0367, firstname.lastname@example.com.
(07) Enhancing Clinical Trials
(08) Genomics
08-HG-101* Technology and resources for high-throughput functional analysis of functional elements in genomic sequences. Computational and experimental research programs are currently identifying thousands of putative functional elements (e.g., genes and regulatory sequences) based on their sequence properties; however, new, robust, high-throughput methods are needed to carry out functional assays to determine whether and how these elements operate to determine cell states, in development, and in health and disease. Such new methods should include both cellular and whole organism methods to allow systematic analysis of the effects of both genetic (normal variation and mutation) and environmental perturbations, and should include methods for both molecular (transcriptomic, proteomic) analysis and high-throughput phenotyping. Contact: Dr. Elise Feingold, 301-496-7531, firstname.lastname@example.com.
(09) Health Disparities
10-HG-101 New information technology and resources for disease prevention and personalized medicine. Family history information forms a cornerstone for the delivery of preventive health care and the future of personalized medicine. The open-source electronic family history collection tool My Family Health Portrait (MFHP) created by the U.S. Office of the Surgeon General offers interoperability with both personal health record and electronic health record systems. MFHP provides a starting point for the development, validation, and study of compatible, open-source, electronic risk -assessment tools for preventable common chronic conditions in the context of existing health information technology systems. Much needed research on developed tools could include: qualitative and quantitative investigations of patient, provider and health system uptake, satisfaction, and utilization of such tools; qualitative and quantitative investigations of the effects such tools have on patient and provider behavior or health outcomes; or the effect such tools have on the appropriate utilization of downstream health care services. Such studies will provide a paradigm for future studies of risk assessment tools that make use of personal genomic information. Contact: Dr. Ebony Bookman, 919-541-0367, firstname.lastname@example.com.
(10) Information Technology for Processing Health Care Data
(11) Regenerative Medicine
(12) Science
(13) Smart Biomaterials - Theranostics Technology, Engineering and Mathematics Education (STEM)
(14) Stem Cells
(15) Translational Science
For general information on NHGRI's implementation of NIH Challenge Grants, contact:
Dr. Mark Guyer
NHGRI/Division of Extramural Research
National Institutes of Health
5635 Fishers Lane, Suite 4076 Bethesda, MD 20892-9306
Telephone: 301-496-7531
For Financial or Grants Management questions, contact:
Ms. Cheryl Chick
NHGRI/DER/Grants Management Branch
National Institutes of Health
5635 Fishers Lane, Suite 4076
Bethesda, MD 20892-9306
Telephone: 301-435-7858
Last Updated: October 1, 2012

subset: commoncrawl


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Prompted by cousin Russ Worthington's When to enter data into your genealogy program and Randy Seaver's Are You an Evidence-Based or a Conclusion-Based Genealogist? two concepts emerge in Ol' Myrt's mind.
- When to enter info
- What to do with disproved info
In Oct 2010, I reported on a Second Life discussion of the Genealogical Proof Standard. "What developed was a serious discussion of WHERE to keep a digital copy of research and analysis during the research process that can take many months or years before concluding. One participant explained she has to flip through her paper pages wasting time looking for an obscure notation. We all agreed that paper note-keeping isn't productive since it doesn't permit a computer to do an every-word search of the contents." See: Note-keeping during the research process.
It was in that blog post Ol' Myrt here stated: "The necessity of a note-keeping program assumes we're not ready to place the information into our genealogy management program. (Ol' Myrt here doesn't like to enter names and info until a family relationship has been established.)"
My reasoning? I wanted to keep my genealogy database "clean", meaning free from error.
What has evolved is my understanding that conflicting evidence and disproved family relationships must remain part of my database, quite simply so I can discuss my reasoning with the next researcher who continues to prefer the erroneous material.
If I delete disproved parents from my database, I also remove my notes about documents attached and inferences drawn. Where else should that information be stored except right with the ancestor in question in my database?
The software I use provides a top level view of conflicting evidence in the "Edit Person" screen, without having everything buried in notes. If I enter three different birth dates, I can see them listed in the "Edit Person" screen. Clicking "Notes", "Citation" and "Media Album" provide access to details.
Like Randy, I grew up on PAF, which forced a conclusion. In the case of multiple birth dates, PAF made me decide which was "correct" and type that date in the only available birth field.
Fortunately the genealogy software Ol' Myrt now uses, permits multiple parents (birth, adopted, step, foster, related, guardian, sealed and unknown) and multiple facts for events (birth, marriage, death, among many others). I can also assign a proof factor (proven, proven false or disputed) for each document, though not for each bit of info provided in that document, unless I am careful to add a "fact" entry for each bit of info. For instance:
Typically a beginning genealogist takes pictures of ancestor's tombstones, thereby acquiring abbreviated information about the decedent. Here we "learn" that Alma O (partially obliterated by the sun spot in the image below) Player was born 1862 and died 1929.
Having visited the Salt Lake City Cemetery with family members, I know this to be my paternal great-grandfather, Alma Oades Player. If I were entering "facts" provided by this tombstone there would be two entries regarding Alma -- his birth year and his death year. Both "facts" will show up nicely in my genealogy program's "Edit Person" screen in date order.
Death Certificate
State of Utah - Death Certificate, State Board of Health File No 2047 indicates the full name of the decedent as Alma Odds Player. Many other documents, and my father's personal knowledge of his paternal grandfather indicate "Oades" is his true middle name, derived from his mother's maiden name.
Oddly enough, I located a 100% typed version of this record today at FamilySearch.org, but I digress.
Using the old PAF genealogy program, I'd have to draw a conclusion about Alma's middle name Oades, though this document doesn't show it. I typically placed conflicting evidence in "notes" for the individual. With my modern genealogy program, I can put in an alternate name, providing "notes", "citation" and "media" (the image of the certificate shown above) for each statement of "fact".
Death Date
Fields 16-18 constitute the "Medical Certificate of Death" portion of the document. Here the physician J. J. Galligan, M. D. certifies the death occurred "Nov 26th 1929". Cause of death was "unknown but natural, no physician attending". No operation preceded death, there was no autopsy. I'd enter the death date and place "Salt Lake City, Salt Lake, Utah" providing "notes", "citation" and attaching the same certificate image under "media" for Alma's death fact. I can also indicate the death info is "primary" (first hand) information since the physician signed the certificate during the normal course of his work, signed the day after the death occurred.
Birth Date
The death certificate indicates the birth date of Dec 12th 1861 is provided by "informant" Acel Richardson. Now I knew Acel to be a responsible person. He married one of Alma's daughters. However, the 1861 year of birth does not agree with the birth year 1862 from the tombstone previously entered in my genealogy program. Do I change the birth date? No, I merely add a second "birth fact" based on the info from the death certificate. I do not describe this birth info from the death certificate "primary", because the informant, Acel, was most surely not present at the time of his father-in-law's birth, and probably only knows the 1862 date from family tradition. Acel may have had access to the family bible but I've never seen it.
Indeed, Ol' Myrt here needs to review the birth records for Salt Lake County, Utah for the years 1861 and 1862 to determine which is the precise birth date. I'd then enter the information as a "fact" about my great-grandfather, indicating the birth record as "primary" in the genealogy program, since the county birth register is an "official document" created close to the time of the event by someone who has no other motivation than to perform his regular function as recorder in the county clerk's office.
If I find Alma in a "birth index" I'll enter that information in my genealogy program if I am not within the hour also retrieving a copy of his official birth record. The reasoning here is that I may not get to the birth record for a few months or years, and the index is all I'd have to go on at that point.
However, there maybe differences between the index and the actual entry. I've seen this in marriage record indexes compiled by local genealogy societies. I am of the belief that if the information differs, I should also list the info from the index in my records about a ancestor. If the index agrees with the final record, I consider it nothing more than an indexed entry at the end of a book, and don't include the info as a "fact" in my genealogy program's "Edit Person" screen.
In another case, it took me 9 years to act on information provided in an index. My notes for the burial of my Union Veteran William Henry Phillips lists the following info:
"28 Nov 1999. Orlando Public Library. Today I ran across Marion County Genealogical Society's bicentennial project for 1976, Cemeteries of Marion County, Iowa. Buried at Graceland Cemetery, Knoxville, Marion, Iowa (Old Section) Block 14 lot 6 is Estelle Mae Goering 1876-1921. I was very surprised to see that buried next to her are those I know, from family bible entries, to be her parents. It was also surprising to see that all three died in 1921. Perhaps there was an epidemic in the area that affected them?"


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Leavenworth upended by Shawnee Mission South.
What the Immaculata soccer team lacked Wednesday in its season opener, it discovered Thursday against Atchison.
Led by a five-goal performance from forward Nick Reckers, the Raiders found its scoring touch to earn its first win of 2012 — a 6-1 victory.
"I told them before the game that we needed to keep the shots low, that we couldn't have a repeat of last game," Imac coach Frank Mazeitis said. "Sure enough, that is what we did and we got six goals out of it."
It was an onslaught start for Immaculata. The team in green scored three goals in the opening 15 minutes of play — the first coming from Mark Hernandez and the next two off the boot of Reckers. Each assisted the other, expect for the third strike, which was built off a booming kick from goalkeeper Phillip Hernandez.
After that, the game slowed a little and Atchison was able to chip in one of its own. Yet, the day belong to Imac and specifically Reckers, who knocked in the next three goals. The last was the best according to Mazeitis, as Reckers heel-kicked a loose ball past a sprawled out goalie.
"You have to give credit to the defense too," the Raider coach said. "Isaac (O'Neil), Jaxon (Qualley), Beth (Doty) and Nathan (Reardon), who took over for Jacob (Chapman) due to injury, played great. Phillip is just doing fantastic and keeping us in these games."
Immaculata finished the game with 18 shots on goal while Phillip Hernandez made 15 saves. The squad, 1-0-1, will have a full week to prepare for its next match — a 4:30 p.m. showdown at Maranatha Thursday.
LV can't keep up with SM?South
Different day, same result.
After losing 4-1 in its opening contest of the Fat Cat Tournament on Tuesday, the Leavenworth boys' soccer team was tripped up by the same score on Thursday — this time by Shawnee Mission South.
"Our guys just couldn't really step up today," LV coach Ken Lott said. "You can't blame it all on them, but they just weren't themselves. They just couldn't find their touch."
The Pioneers remained scoreless until the second half, where Cameron Hayes tallied his second goal of the season. The strike placed the deficit at 3-1, but that was all the Leavenworth offense could muster against the Raiders.
LV, 0-2, will play its final game of the Blue Valley West competition at 9 a.m. Saturday against an opponent yet to be determined.


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NJ Seeks To Stop Misuse Of 'Locally Grown' Label
The New Jersey agriculture board says it fears some produce advertised as "locally grown" is being trucked in from hundreds of miles away.
The problem is the state doesn't have a rule defining what "locally grown" means.
The board, the policy-making body of the state Agriculture Department, wants to change that. It is proposing that the label be reserved for items grown in the Garden State or within 30 miles of its borders.
The board's president tells the Philadelphia Inquirer it's a matter of truth in advertising.
The draft rule will be taken up at the New Jersey State Agricultural Convention this winter.
Consumers who want to be sure they're getting Jersey-grown produce can look for the state-sanctioned Jersey Fresh logo, which also guarantees certain quality standards are met.


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Monday, 7 May 2012
Duffel Bag
I travel a fair bit so I thought it was high time for some pretty hand luggage, conveniently finished just in time for my holiday.
The pattern is by Studio Cherie, I used Melody Miller typewriters for the main body of the bag (oh how I love them!), a coordinating print from Ruby Star Shining for the pockets and So Sophie Dots by Riley Blake for the handles.
This bag is huge!! I stuffed it with a quilt and two cushions for the photo and there is still room for more! I have never made a bag this large before but it was fairly straightforward and the pattern is easy to follow. I did not particularly enjoy wrestling the bulk of quilted fabric, handles and zippers on my sewing machine but it was well worth the effort.
I felt very smug walking through the airport with my handmade duffel bag, not that anyone took notice of it but still. I fancied myself to be one of those stylish mums with her hip bag full of healthy snacks and entertaining toys for the little one, looking effortlessly glamorous and all. But it is just a bag really, so I ended up rummaging through Happy Meal toys and Maltesers to find the Fanta instead ;)
It's good to be back!
x Leila
27 comments:
Good to have you back Leila! I bought this pattern ages ago, wanting to make it with my precious momo wonderland teatime tomato twill, but I am scared... If I mess it up I can't get that fabric anymore.. Well done doing yours, it looks fab! Was it hard?ReplyDelete
this bag looks great-i love the colors too :)ReplyDelete
Soooo cool! I want one for each of us 4! Thanks, so inspiring! I love the typewriters.. will soon be available in my shop too *.* xxReplyDelete
Great bag! Nicely done :-)ReplyDelete
THe bag looks fab, and I love your fabric choices! Might be a project to put on the to do list :)ReplyDelete
Oooh, fab new luggage! Half of me wants to make new luggage to take to the FQ Retreat and Sewing Summit, and the other half of me is telling me to get a grip ;o)ReplyDelete
Wow - back with a bang. Love that bag.ReplyDelete
welcome back! i love your bag so much. it's so cheery.ReplyDelete
Love this bag! Hope you bring it to retreat so we can have a lookie!!ReplyDelete
Super cute Leila! That typewriter fabric is so perfect. I'm glad you've already been able to use it too.ReplyDelete
Oh I bet there were lots of whispers at the airport about your very stylish bag!ReplyDelete
Gorgeous bag and worth the wrestle. Hope you are feeling a lot better and all refreshed and read for FQ in a few weeks!ReplyDelete
I love that! The bag is adorable and the smug feeling in the airport is priceless! No one else will ever know your bag has seen a happy meal :)ReplyDelete
Oh wow that looks fab!ReplyDelete
Fab bag and sooo worth the wrestle.ReplyDelete
Absolutely brilliant - can;t wait to see it in real life xxxReplyDelete
That is one cool bag even if it does hold Fantas!ReplyDelete
So inspired! Love all the fabric today! I got a pattern from McCall ( It is similar style). I haven't found the main fabric for it! I bet it feels good to carry something that you made around! I giggled when people stopped me and ask where did I buy my bag. :)ReplyDelete
LOL brilliant. Love the bag too... I've always fancied having a go at doing a large bag like that but found most patterns to be so daunting since they seem to require soooo much fabric. Would you recommend that one then? It does look pretty awesome....ReplyDelete
yay leila! love the duffle, you were totally the coolest mom I bet. glad you're back, I almost emailed you last night! :) missed youReplyDelete
Great bag! It is cool to make something for yourself. You know people were secretly taking a peek!ReplyDelete
Ha healthy snacks =P
I LOVE it!! Your fabric choices are perfection -- like usual!!ReplyDelete
Me and my REALLY crap luggage are incredibly jealous!! Beautiful :)ReplyDelete
Just wonderful!ReplyDelete
Oh I love the bag - the fabric choice is wonderful.ReplyDelete
ha! if i would have seen you in the airport with that bag i would have totally told you how much i love it and then i would have realized it was YOU and then i would have hugged you! xo i have the same pattern and am looking forward to making one for myself!ReplyDelete
Looks fantastic. I have the pattern, but have yet to find the right fabric! So tough to get it right :o)ReplyDelete


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momo5406 on Family Tree Circles
view: full | list
Journals and Posts
Looking for Skipper's of AL & GA
My Grandfather was Wm. Nevlon Skipper, g-grandfather Wm. Charlie Skipper, g-g grandfather Wm. Skipper AL. Looking for more information or maybe some pictures.
My father used to tell me that we are descendants of the Cherokee. He wouldn't say much more than that. Some of our family have Indian characteristics. I don't know if maybe over the generations the name changed. It would be interesting to find out.
- Displaying 1-1 of 1 Journals
- 1
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Presented ByCindy Berg Wagner
Broker, Licensed in Oregon
Prineville is a small town with a big personality, located in the high desert of Central Oregon. Founded in 1868 by settler Barney Prine, the area began as a blacksmith shop and saloon built on the banks of the Crooked River. It slowly developed into a bustling community, and until 1911, was the region's primary center for trade. When the Union Pacific and Oregon Trunk Railroads extended south to Bend, Prineville's growth and business came to a halt. Taking action, locals voted to build their own railroad connecting to the main line 19 miles away. Proving to be a success, the town prospered from a booming lumber industry. The cities of Culver and Madras are located nearby.
Prineville is a delightful desert town focused on revitalization. With a strong network of local entrepreneurs and business owners who are expanding and establishing new ventures, the area's economy has sustained momentous growth. Residents are dedicated to preserving the city's western heritage while embracing expansion and development. The moderate climate and high quality of life make Prineville one of Central Oregon's most desirable locations.
Homes reflect Prineville's western heritage in a changing environment. New construction developments provide modern amenities without harming its surrounding natural beauty. Large, luxury homes constructed with high-end materials and custom finishes feature scenic views and desert landscapes. Other real estate includes farms, acreage, and ranch style homes in traditionally designed neighborhoods.
At the center of the Prineville community is the eclectic downtown district. Dozens of boutiques and specialty stores line the streets where you'll find feed stores next to galleries and saddle shops next to fine jewelers. Golf lovers flock to the resort's highly respected golf course designed by golf legend Peter Jacobsen. Other resort amenities include spas, fine and casual dining, horseback riding and social events.
Surrounded by parks, rivers, and mountains, outdoor activities abound. Welcoming visitors interested in camping and exploring is the beautiful Prineville Reservoir State Park. During summer months you'll find locals and visitors swimming, boating and fishing in the park's cool blue waters. Powell Butte Nature Park is located between Prineville and Redmond and has over 600 acres of trails for hiking and biking. Families congregate at any of the area's eleven parks offering maintained multi-use paths, play structures and heated outdoor swimming pools.
Private mortgage insurance is an insurance policy that a residential mortgage lender requires of the borrower if the loan-to-value (LTV) ratio of the home is greater than 80%. Mortgage insurance protects the lender from the risk that the borrower may default on the loan. Federal law requires lenders to notify borrowers when the loan-to-value ratio drops below 80%. Mortgage insurance premiums vary, but generally range from $1,000 to $5,000 a year for an average priced home.
Assessments are monthly fees such as Home Owners Association(HOA) Fees etc... Results received from this calculator are designed for comparative purposes only, and accuracy is not guaranteed.
Information deemed reliable but subject to change without notice. Qualified buyers only, subject to credit approval. This is not a commitment to lend. Consumer Loan License NMLS-3240, CL-3240.
In association with our #1 preferred local lender, Directors Mortgage, Hasson Company, Realtors® is able to provide a full spectrum of financial services, from online pre-approval to offering a guiding hand throughout the entire home buying process.
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The content relating to real estate for sale on this web site comes in part from the IDX program of the RMLS™ of Portland, Oregon. Real estate listings held by brokerage firms other than Hasson Company, Realtors® are marked with the IDX logo, and detailed information about these properties includes the names of the listing brokers. Listing content is copyright © 2015 RMLS™, Portland, Oregon.This property was last updated: April 3, 2018 3:43 PM


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Rebecca Verity needed a new logo design and created a contest on 99designs.
A winner was selected from 154 designs submitted by 42 freelance designers.
B Online Learning is a eLearning solutions and online training company based in Sydney Australia. We have partnerships with two global companies Atlantic Link in the UK and Operitel in Canada. We offer courses in eLearning, management, education and Microsoft Office suite and Microsoft Techncial courses.
Corporates, small medium business, government agencies and individual students participating in our courses.
We need a new logo that will really grab the attention of our clients. We see ourselves in the media industry more so than education so we are looking for a cutting edge innovative design.
Our existing logo is a bit tired looking and consists of our company name and a tick made out of circles. We would like to keep the tick, dots and company name and also use the existing colours – white, blue, green, shades of purple.
To see our current logo please go to:
Our strapline - Innovative Flexible eLearning Solutions - is not required in the logo.
We are rebranding our website too and are looking at making circles very much part of our branding.
There is the possibility of future work to help us re-brand our company stationary and also a corporate brochure.
Find out how a design contest works or learn more about our logo design services.


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Joan Rivers gets the star-studded farewell she wished for
Dozens of celebrities have paid their last respects to comedian Joan Rivers in Manhattan.
Hugh Jackman and the New York Gay Men's Chorus performed at the ceremony, which was also attended by stars including Whoopi Goldberg and Sarah Jessica Parker.
The pioneering 81-year-old died after suffering a heart attack during a routine medical procedure on Thursday.
The New York state health department is now investigating the circumstances surrounding Rivers' death.


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Ready to Buy?
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JanetBasket Lime Large Aluminum Frame Basket
18" x 10" x 9-1/2"
Item #: NOM087305
FREE Shipping on this item with any order over $49
- Aluminum Frame Bag.
- This amazingly lightweight tote features aluminum exterior structure and is completely collapsible.
- Originally designed as a market tote it is also a super versatile project tote.
- The metal structure keeps access to goods inside immediate.
- This bag features durable canvas; a brushed nickel look with black webbing accents gives these totes a modern contemporary look; the canvas handle cover makes it comfortable to carry and allows handles to be folded completely out of the way.
- Choose from two sizes: Large-18x10x9-1/2in or Small-16x9x8in.
- Available in a variety of JanetBasket unique patterned and solids fabrics.
- Imported.
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Tagged: julius shuman
#22 Shulman
Visual Acoustics (dir. Eric Bricker) is a magnificent documentary about Julius Shulman – the man who pioneered Southern California's Modernist Architecture with his photographs.
A man of wit and passion for the environment, he worked along side architects such as Frank Gehry (Disney Hall), Albert Frey (Frey House), and Richard Neutra (Kauffman Residence). Most of his photographs were taken in black and white to emphasize the contrasting geometric patterns found in these modern homes. Some say his photographs, carefully taken with the concept of a "one-point perspective", make these houses seem even more beautiful than they are in real life; that his prints actually sell these buildings in the market.
One of his famous photographs (seen above in the poster) is of the Stahl House – Case Study House #22 designed by Pierre Koenig in 1960. It sits atop the Hollywood Hills (known to be an unbuildable site) overlooking the city of Los Angeles.
den / kitchen
bedroom / pool & deck
(photos by julius shulman)
The Stahl House is a popular set for film and fashion shoots even to this day. It was used in movies such as Galaxy Quest, Playing By Heart, and The Big Lebowski as Jackie Treehorn's home. It was also featured in the video game Grand Theft Auto: San Andreas as a safehouse!
If you're interested in photography and architecture – heck, if you're interested in art in general – I HIGHLY suggest you watch this documentary. Shulman is now a very big inspiration of mine. Sure he's worked with big names in the architecture world, but in the end, he's really an ordinary guy who is very passionate about what he does! And with that, I'm going to make it one of my life goals to visit at least one of the houses he has shot.
Julius and his garden
(click thru photos for source)


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Black Law Students / Re: The Howard Law/HBCU Law Schools Thread« on: January 04, 2008, 07:52:27 AM »
Full ride @ Howard OR uber-debt @ Georgetown/Duke ??
I read the earlier discussion re: UVa and found it very helpful, but I'd like to get fresh perspectives on this....
Thanks in advance.
I go to Howard. It is a great school. There are so many recruitment opportunities and chances to network. I literally have 30 e-mails in my mailbox right now concerning job opportunities. There are seminars and panels, luncheons and cocktail parties, mock interviews and resume reviews, and invitations to apply for clerk positions and government jobs. Employers come to Howard, obviously, looking for black students.
Howard is a unique school. It's Tier 3, but I know a student who will be working at WLK when he graduates in May. Traditional wisdom states that if you finish top third a job at market rate is yours, as in employers will seek you out and compete for your services. 1L's have OCI in the Spring and a minority land associate positions their first year.
The professors are excellent. One of my teachers worked on the Jena 6 case and the Seattle school segregation case; students who are part of the Civil Rights clinic also were able to contribute.
We are almost like one big family. I did not pay for half of my books because 2L and 3L students gave them to me along with outlines and advice. It is a very nurturing community; fun, even. I have had the time of my life, in this, my first year.
I cannot speak on Georgetown extensively, or on Duke at all. However, the black people I have met at Georgetown seem like good people. And just from my own snap judgements on the few Georgetown students I met, it seems like the best at Howard can easily compete with Georgetown students. I know several people who turned down offers at NYU and VA and Gtown to attend Howard. Indeed, a lot of people who attend Howard look past the numbers (rankings, bar passage, etc ) and come anyway. In my opinion, this contributes to the environment at Howard and the prevailing feeling that we are there to be more than just lawyers, but social engineers with a conscious.


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JiaYu G3 and iPhone 5 looks similar, will JiaYu get sued?
Well, I bet we all know already about the recent Apple vs Samsung trial from which Samsung lost the court and is billed to pay $1B for damage. That is because it was said that Samsung infringed the patented designs of Apple on its products.
Now, September 12 is the date that might be already marked on the calendars of iPhone fans. Its the said release of the iPhone 5.
So what's the relation of this on this China phones blog of mine? While browsing my feeds today, I saw
this pic:
It is being said that the next iPhone might look like this on surface. Which reminds me of,
yes the JiaYu G3.
They have similarities in terms of physical aesthetics, do you agree?
So what will happen next?
I do not know. The only thing I am sure is, I cannot really wait any longer for the JiaYu G3's official market entrance. This month, the JiaYu G3 must be out on sale already, it should be; and I will definitely be one on the first line to get it overseas. Its time to replace my pre-loved 4.3″ MT6575 device with this awesome JiaYu G3 baby.
Back to patents infringing issues, then why does these Chinese makers of iPhone clones arent sued? Maybe because they didnt steal, they just copied? LOL
Popular iPhone knock-offs are: GooPhone Y6, Google 4S M100, and KuPhone S9.
Let's not think about that anymore, now back to our regular programming.


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A volunteer at the Tachlit center are busy dividing hordes of food into boxes, to be distributed to needy families before Shabbat and before the coming Jewish new year in Jerusalem.
Tomchei Shabbat (supporters of Shabbat) organizations like Tachlit flourish throughout the Haredi communities, each with its unique, local flavor, but all of them with one, central goal: feed the needy.
Most of them also deliver the food boxes quietly, so as not to shame the recipient. In many places there's also a feedback system in place, allowing recipients to indicate which goods they like and which they'd rather not receive. It prevents waste, and also makes the proces look more like shopping than like charity.


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Sunset View ApartmentsNEARBY - Hinckley, IL 6052041.770399734377861 -88.642923608422279BEDROOMS1 - 2
Good Life Senior Residences at Pat Crowley HouseNEARBY - Chicago, IL 6066041.996116638183594 -87.669296264648437
What Kind of Housing Do I Need?
Senior Housing Listing Type Descriptions
55+ and 62 + Communities:
Age-restricted to residents at least 55 or 62 years old.
Active Adult:
An active Adult community is an Apartment community or a housing development that caters to 55+ adults who don't need any medical assistance or services such as transportation, or prepared meals.
Multi-family housing; may be for all ages or seniors only.
Homes for Sale or Rent:
Single-family houses that may or may not be for seniors only.
Manufactured Homes for Sale or Rent:
Factory-built houses, on a permanent chassis, installed on site.
Independent Living:
Complexes with dining, housekeeping, transportation, activities.
Assisted Living:
For personal help with daily activities like bathing, dressing, meds.
Alzheimer's/Memory Care:
Memory care, often with medical staff, for dementia patients.
Continuing Care:
Tiered options, from independent to assisted, to age in place.
Nursing Homes:
Skilled nursing facilities that offer 24-hour medical support.
Low-Income Senior Housing:
Subsidized housing for seniors earning below set income limits.


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as good as
as good as
very nearly
1997 - Cosmopolitan - If you are famous, you can't allow someone to diss you without retaliating - it's as good as admitting they're more important than you.
all to the good
to be welcomed without qualification
as good as gold
extremely well-behaved
as good as new
in a very good condition or state, especially close to the original state after damage, injury or illness
be good news
be an asset
be commendable or admirable - informal
be in good company
be in the same situation as someone important or respected
be to the good
have a specified amount of profit or advantage
1992 - Guardian - By then Sheffield were a goal to the good.
come up with the goods = deliver the goods
do what is expected or required of you – informal
get the goods on someone = have the goods on someone
obtain (or possess) information about a person which may be used to their detriment – informal
good and
used as an intensifier before an adjective or adverb - informal
1998 - Barbara Kingsolver - The Poisonwood Bible - As soon as I had her good and terrified I'd slip away.
good oil
reliable information – Australian informal
This expression has behind it the image of oil that is used to lubricate a machine and so ensure that it runs well.
good Samaritan
a charitable or helpful person
In the Bible, Jesus tells the parable of a man who went down from Jerusalem to Jericho and fell among thieves (Luke : 10). The first two people who came across him lying stripped and wounded by the side of the road passed by on the other side. It was the third man, a Samaritan (i.e. a man from Samaria) who took pity on him and helped him.
have a good mind to do something
be very much inclined to do something
in good time
with no risk of being late
in due course but without haste
in his good books
in favour with someone
make good
be successful
no good to gundy
no good at all – Australian informal
1955 - Nina Pulliam - I Traveled a Lonely Land – Just cards and races and booze—and fighting. No good to Gundy!
one good turn deserves another
if someone does you a favour, you should take the chance to repay it
take something in good part
not be offended by something
up to no good
doing or intending to do something wrong – informal
1997 - Iain Sinclair - Lights Out for the Territory - 'Here we are then,' he said, 'two boyos from the valleys up to no good in the big, wicked city."
as good as :
Idioms Index – Previous Page


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Dorotka Goldstein
Born: February 1, 1932
Warsaw, Poland
Dorotka was the youngest of three children in a Jewish family. Her father was the director of the Jewish Telegraphic Agency in Warsaw and worked for a popular newspaper. An avid Zionist, he had traveled to Palestine.
1933-39: My father established a soup kitchen in Warsaw for Jewish refugees who had fled from Germany. In September 1939 I was supposed to begin first grade when war broke out. My father escaped to Vilna with other Jewish leaders. People were suffering, but I didn't understand why. I was content with my playmates and my dolls.
1940-44: After my father brought us to Vilna, the Germans killed him and deported me, my mother and sister to the Stutthof camp. My mother died slowly of hunger. When my sister and I were sent to be gassed, a German saved me, saying, "Look at this rotten Jewish child; she has such beautiful eyes." My sister waved so I wouldn't follow her. When the Soviets neared Stutthof, two Germans with machine guns shot everyone in my barracks. Lying sick on my tummy and weighing just 40 pounds, I felt the sting of two bullets in my back.
Dorotka was found unconscious in her bunk two hours later when the camp was liberated by Soviet troops on May 9, 1945. She immigrated to Israel in 1952.


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Evee is my Bichon Frise and the princess of the house. She was born on Christmas Eve in 1999 (hence her name)! Evee loves hiking, kayaking, going to the beach, and chasing squirrels! Just like her predecessors, Evee loves entertaining us with her "Bichon antics". Evee has recently started competing in agility and is doing great and having fun! Her favorite obstacle is the A-frame and she lives to jump. Despite her age, she acts like a young pup!
Ollie is a 9 month old Bichon Frise. We joke that he is part pitbull, as he is a very tough little guy!
Ollie is incredibly charming. Very few people can resist him. He loves everyone, and his only fault is that he can sometimes be TOO friendly.
My husband and I love Ollie with all of our hearts and can't imagine life without him.
The Cutest Puppy
I'm Fred. I'm a 4 month old Cock-a-chon puppy. I'm rambunctious, outgoing, and extremely playful! I also love riding in the truck with Mom and Dad. I will run, jump, spin, dance, steal my moms mail, and give LOTS of kisses!


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If you are going to start a home based business, you will need to ensure your business does not negatively affect the neighbourhood. Depending on how you operate your home business, you may or may not require a planning permit.
A home based business must:
If you require any of the following, you will need to apply for a planning permit:
Please consult your local council for more information on home based business planning scheme requirements.
Advisory material provides advice and guidance in undertaking a business.
Fees Details for this service in table format.
Please consult the responsible council for specific information on fees to be submitted with your application.
Planning and Environment Act 1987 VIC
Indigo Shire Council
Contact Email, Phone and Address Details for this service in simple two column table format, header then data.
Indigo Shire Council


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University Relations India. Powering Innovation. Curriculum. Technology. Projects. Research.
In the past decade a lot has changed in the world. For New Global Economy IBM has a blue print for building Smarter Planet in an increasingly instrumented, interconnected and intelligent world. IBM believes that it is imperative to share and collaborate across industries and academia to build knowledge, solution and talent for this challenge.
IBM has a strong tradition of research collaboration with our colleagues in academia. The goal of IBM's Collaborative Research Initiatives is to expedite these collaborations by diminishing barriers and reducing complexities caused by the implications of intellectual property ownership.
IBM University Relations programs are designed to help develop such a globally competitive knowledge backed by unmatched technology offerings that will help create talent pool of adaptive innovators, those with deep education in their home disciplines and ability to think and act across multiple disciplines to meet the challenges of New Economy.
IBM uses various engagements to develop relationship with institutes starting with knowledge awareness programs, student projects, curriculum enablement development tuned to current industry needs and collaborative research. This is supported by vibrant and sustained interaction with students and academia using IBM academia collaboration platform where academia, students and IBMers come together to discuss , share, build knowledge and future directions leading to innovation – a true environment for Social Computing.
Mezjan Dallas, Country Manager
IBM India University Relations
Download & Play INNOV8! (US)
Serious 3D game teaches Business Process Modeling & Analysis


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Wiz Khalifa - The Statement
The street video for Wiz Khalifa's "The Statement" from his mixtape Kush & Orange Juice out now!
Please click the "Report" button below if the video on this page is not working properly.
Comments will only be displayed by verified emails. No Spamming or Racism.


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ESL Open Tutoring - Malletts Creek Branch AADL
Where: Malletts Creek Branch, Ann Arbor District Library (Community Room)
3090 East Eisenhower Drive, Ann Arbor, MI 48108
Description: Practice English in small groups working with volunteer tutors. All levels of English are welcome. It's helpful for learners to bring pens, paper, and a dictionary to group.
No registration required - Join us!
Please be sure to show up at least 5 minutes prior to the start of the group.
Event Properties
|Event Date
|Jun 13, 2018 6:00 pm
|Event End Date
|Jun 13, 2018 7:30 pm
|Individual Price
|Malletts Creek Branch, Ann Arbor District Library


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Pit$Bull wrote:iluvk9 wrote:He was nervous, too.
iluvk9 wrote:You really got back into shape.
DemoDick wrote:iluvk9 wrote:You really got back into shape.
It's all the tasty animals I've been eating.
Demo Dick
maberi wrote:Is Demo sitting in the plane?
maberi wrote:I never thought I would hear the words that Demo is getting sick of consuming meat
I'll swing by with some tofu to help change things up a bit for you
call2arms wrote:If you think tofu's bad, it's because you haven't tried tempeh. I say this as a vegetarian.
Users browsing this forum: No registered users


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Hocking Hills Rock Climbing Trip
Saturday, September 15, 2012, 7 am to 7 pm
Hocking State Forest, South Bloomingville, Ohio
Current Students
The Hocking State Forest Rock Climbing and Rappelling Area has nearly a mile of cliffs ranging up to 100 feet in height. Numerous slump blocks, cracks, chimneys and overhangs provide a variety of challenges to the rock climber and rappeller.
The cost is $40.00 ($30.00 for WSU Climbing Club Members) and includes all equipment, instruction, and transportation.
To register visit the Outdoor Resource Center at 037 Student Union, Monday - Friday from 12:00pm-8:00pm. 937-775-5019


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You are hereHome ›
Narrow Search
Earth and space science
Life sciences
The nature of science
Filters: Your search found 1 result.
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Now showing results 1-1 of 1
This unit focuses on local plant species; students learn to identify common species and will examine their life cycle characteristics as evidence of climate change. Through the use of the national citizen science project titled Project BudBurst,... (View More) students explore the impacts of climate variation on plant species distribution. The unit is one of four under the Chicago Botanic Garden curriculum entitled, "Climate Change in My Backyard." (View Less)
Keywords: Phenology; Dichotomous key; Sequestration; Citizen science
Audience: High school, Informal education
Materials Cost: $1 - $5 per group of students
Materials Cost: $1 - $5 per group of students


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Dior Homme "Butterfly" Installation By Andrea Mastrovito
Commissioned by Dior Homme creative director Kris Van Aasche, the Paris flagship store of the brand was revamped last week, featuring a new "Butterfly" installation by young Italian artist Andrea Mastrovito.
"Nine thousand black decoupage replicas serpentine across the ceiling and walls of the white boutique, like Hitchcock's birds only less menacing, and much prettier." Via Wallpaper.
The installation will be up for one month. Detailed images follow after the jump.


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The advent of Big Data is ushering in a tectonic shift in the field of medical research, one scientists hope could pave the way to snuffing out deadly diseases – including cancer. Over the past decade, the cost of obtaining biological information has plummeted as technology has rapidly improved. Whereas it used to take years to map genomes, researchers can now perform the task on the fly. The changes mean scientists are confronted with near-endless information. The new task is figuring out exactly what to do with it. Specifically, how these vast pools of data can be efficiently mined to help researchers discover new treatments.
Continue Reading Below
Merging Artificial Intelligence and Medicine Berg Pharma is a microcosm of how these dreams might one day become reality. The company is leveraging big-data analytics to create an assortment of drugs targeting difficult-to-cure diseases. The seven-year-old firm currently has numerous experimental treatments in the pipeline, including ones aimed at skin cancers, solid tumors and leukemia. "The big-data analytics with the way we're doing our biology allows us to look at what's gone wrong, and how to fix it," said Niven Narain, Berg's co-founder and president. Narain said the human body is akin to the hub-and-spoke model the air transportation system uses. If there's a snafu at, say, New York's John F. Kennedy Airport, it can easily spark delays and shutdowns across the country. Berg's artificial intelligence system seeks the biological equivalents that cause disease in the body. The company then looks to fix the flaws utilizing vast amounts of information, everything from genes and proteins to raw clinical data. In keeping with its business model, Berg has forged a partnership with the U.S. Department of Defense which will allow the company to access thousands of records on prostate cancer in enlisted individuals. "The Centers for Prostate Disease research at Defense Department has done fantastic work over the past 20 years and has amassed what is the most robust data set in cancer, and they're going to use Berg's platform to analyze that data set and illuminate the full use of that data," Narain said. Narain hopes the use of 'Big Data' will dramatically speed up the drug pipeline in coming years, and also produce significantly more targeted interventions.Big Data Key to Unlocking Missing Links in R&D
Kathy Giusti is taking a similar approach to Berg's Narain. When Giusti was diagnosed with a rare, fatal blood cancer she was given only two years to live. That was nearly two decades ago. At the time of her diagnosis, there wasn't a single drug in the pipeline to help fight or cure multiple myeloma. She founded the Multiple Myeloma Research Foundation with hopes of finding enough resources to create a drug or treatment that would give her then one-year old daughter a chance at remembering her mother. In the years following, Giusti's foundation has not only contributed to prolonging her own life but those of others suffering from the same diagnosis. MMRF has made significant strides and developed six FDA-approved drugs, with another 26 in the pipeline. Giusti credits the availability of massive amounts of data and the ability to combine data from many places for the advancement and rapid development of treatments for myeloma. She said one of the major areas that really helped accelerate research and development is in genomic sequencing. "You have to do that because if you don't understand how the cancer cell is changing as they become resistant to drugs, you'll never figure out how to cure the disease. Sequencing is critically important to identifying subtypes and identifying targets that cross multiple cancers." Bahija Jallal, executive vice president of MedImmune at AstraZeneca (NYSE:AZ), said drug development is expanding and changing the drug pipeline in many different ways – especially in the cancer research and treatment arena. She said being able to sequence a full tumor and understanding what medications are appropriate to target and treat it is already starting to happen. "The question is: Do we understand everything for every cancer. And no, not yet," she said. "For some cancers, there are several subsets – some with one mutation or another – that are basically defects in very important proteins, but that only exist in subsets of patents." In addition to the ability to sequence genomes much more quickly and easily, Giusti said there's been another shift in technology that's made cancer research more effective. "Most of our data is going into electronic health records and everything is digitized," she said. "Those technologies are really facilitating the ability to look at genomic and clinical data over time and figure out what drugs work for which patients." She said the big shift has been on new drugs and the effort to extend the lifespan of those diagnosed with myeloma. The idea is to find a drug that improves the patient's quality of life, and then have new drugs available should the cancer return. "If you understand genomics, it's much more likely you can work toward precision medicine: Getting patients the right combination of drugs based on their specific subtypes of cancer." Echoing Berg's Narain, Jallal said this new era of medicine gives doctors and researchers the power to decrease the time it takes to bring drugs to market because they can "zoom in on" specific patients who are more likely to benefit from certain kinds of drugs and treatment options. Giusti believes this new arena is the key to finding a cure not only for myeloma but for all types of cancer. Jallal agrees, and says now the question becomes how to leverage the large quantities of data researchers have so that it can be used to efficiently develop new treatments. "The big hurdles are the diseases," Jallal said. "Every time we think we understand, when we think we can (cure) it, cancer always will evolve and outsmart us. And we have to come at it with different weapons. The second challenge is bringing science as fast as we can to the patients."


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Difference between revisions of "Franschhoek"
Revision as of 19:46, 9 August 2008
Franschhoek [8] (Dutch for 'French Corner') is a city in the Cape Winelands of South Africa.
Franschhoek was founded by French settlers (hence the name), who fled the inquisition in Europe and were looking for a little hide-out on the other side of the world. They found it in the fertile valley of Franschhoek - initially known as Oliphantshoek, as they valley was known for its large numbers of elephants.
Even though most people don't speak French, many of the street names, restaurant names and wine farms in the 'French Quarter' have French names.
Franschhoek makes a serious attempt at being the food and wine capital of South Africa and there are many fine restaurants. It's a great place to relax, enjoy top food and wine, in a spectacular atmosphere.
Get in
Only one road (R45) leads to Franschhoek from Stellenbosch or Paarl. For a more scenic drive, you can enter Franschhoek all the way over the "Franschhoek Pass" - a spectacular mountain route leading into Franschhoek from Villiersdorp.
There is a taxi service (small buses with loud music and often loud drivers) from Stellenbosch and from Paarl.
There's no train service.
Get around
You can walk along the main street to have a look at the shops and various restaurants and a stroll through the streets off the main street will show you some nice old houses.
Franschhoek is a place to relax. Stroll up or down the main street and take your time to have a look around. The mountains surrounding Franschhoek are spectacular and there are many places you can reach within easy driving distances.
There are many excellent restaurants in and around Franschhoek. Along the main road are a number of very good restaurants.
Wine is plentiful and cheap.
Haute Cabriere and La Petite Ferme (see above) sell their own wines. Just outside of the village are two top wine estates, Le Grand Provence and Boschendal, where tastings are available daily. There are also many other smaller wine estates in the area. Virtually all welcome visitors and tastings can be arranged with most.
Get out


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Assmbly Considers Tuition For Those In US Illegally
Lawmakers are set to consider a bill Monday that would allow people who are in the country illegally to pay in-state tuition at New Jersey colleges and universities.
The Assembly Budget Committee will decide if the bill, designed to take effect in the fall, will advance in the state legislature. It has not yet been introduced in the Senate, but the bill's sponsor expects to get some support from that side.
To be eligible for in-state tuition rates, people in the country illegally must have attended a New Jersey high school for at least three years and have a diploma from a state high school or the equivalent.
To qualify, students must also submit an affidavit to the university stating that they have filed or plan to file an application to legalize their immigration status as soon as they are eligible to do so.
Eligibility is contingent on a measure in the U.S. Senate that aims to reform immigration laws, including the creation of a 13-year path to citizenship for some 11 million people now in the country illegally.
Under current law, students in New Jersey illegally must pay out-of-state tuition because they cannot formally declare they reside in the state.
At Rutgers, the state's largest university, it would mean students pay about $13,000 less in tuition annually. In 2012, New Jersey had more than 430,000 students enrolled in state colleges and universities, according to the state Department of Higher Education.
It is unclear how many of those would be affected by the bill. The state has the fifth-highest population of people who are here illegally, according to the Pew Research Center.
To date, 12 states have enacted laws that allow people there illegally to pay in-state tuition, according to the National Conference of State Legislators. Six other states have passed measures that bar those living there illegally from paying in-state tuition.
Students in California and Kansas have sued over the matter, arguing that offering in-state tuition to students there illegally while charging U.S. citizens out-of-state tuition rates violated federal immigration laws. The Supreme Court denied hearing both cases.
The bill's sponsor in New Jersey, Assemblyman Gordon Johnson, D-Englewood, said he proposed the bill to give young people a better chance at an affordable education.
Johnson said that he modeled the bill after national immigration reform efforts and that it's necessary to make affordable education available to everyone.
"It's all about ensuring that we treat everyone as fairly as we can and give them opportunities to achieve their goals," Johnson said.
Johnson said the aim of the bill is to ensure young people "become taxpayers and not tax takers."
(Copyright 2013 The Associated Press. All Rights Reserved)


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Since TomKat split, we've heard rumors here and there about Katie Holmes stepping out with this guy or that guy. We've kept our fingers crossed that maybe somehow Joshua Jackson would ditch longtime love Diane Kruger and head back to the Creek with Katie. Or Chris Klein would come back into the picture like a knight in shining armor. But nah. So far, Katie has stayed squarely single in her post-divorce life. Though rumor has it that she may start dating again soon!
But wait, it's not so simple. A "family insider" was recently clucking about what's next for Tom Cruise's ex. While she might be getting ready to look for a new relationship, she also has some reservations ...
The insider claims:
Katie's in a dilemma, because she wants to date but is concerned where it could lead to from there. She's worried that if she commits herself fully to another man, she will have to give up the freedom she's enjoying so much at the moment. As a single woman, she has no one controlling her nowadays, telling her what to do or who to see and she absolutely loves it!
Oof, so I guess Xenu didn't leave Katie scar-free after her split ... She's worried about being "controlled"?! Poor thing! When you find the right man, you are partners. You make decisions jointly. You are happy to do as you please. (Well, I guess unless you're in love with Christian Grey, but that's a whole different story ...)
The good news is that it sounds like there's some hope for the former Miss Joey Potter. The family insider continues:
However, at the same time, she also misses being with someone special to share experiences with and she doesn't want to be alone for the rest of her life. Katie's got Suri for the time being, and she is her best friend, but she does eventually want to find a man she can be that close with as well. She's just a little nervous and cautious about relationships still right now.
Well, who could blame her, really? After what I'd bet she's been through, I understand her wanting to be cautious -- for her own sake and Suri's! It's hard enough just being a celebrity and not knowing if someone wants to be with you for you or because you're rich, famous, and used to be married to Tom Cruise, obvy! But seems like the sooner she moves on and puts her first marriage behind her, the better! Can't wait for her to meet the right guy, because it'll be awesome to see her happily in love again (or for real ... whaaatever).
Would you want to see Katie start dating again soon? Who could you see her with?
Image via Splash News


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The movie "Lincoln" inspired me to read "Team of Rivals: The Political Genius of Abraham Lincoln," the book by historian Doris Kearns Goodwin upon which the movie is based.
The movie "Lincoln" inspired me to read "Team of Rivals: The Political Genius of Abraham Lincoln," the book by historian Doris Kearns Goodwin upon which the movie is based.
I'm about 440 pages into the book so far, and one thing that strikes me is the role newspapers played in the nation during the time period of the mid-1800s. Many papers aligned with the various political parties, and their reporting would not be considered objective by any means. Yet most of the population relied on newspapers to learn what was taking place in the young nation.
Contrast that with the outlets to which people turn today to learn news. Radio, television and the Internet all came along in the 20th century. Smartphones took off in the 21st century. Suddenly, people could turn to numerous sources to find out what was taking place.
Yet newspapers remain, utilizing many platforms — print, web, mobile — to deliver the news gathered by professional journalists. The objectivity that was missing from partisan papers serves as a cornerstone of journalism today. Part of that objectivity means verifying information that may appear on other sources.
That verification process can take time. Sometimes word may filter out on Facebook, Twitter or other sources that lack official confirmation. We hold back on publishing news until we can make sure of its accuracy.
This can be frustrating when we know something has happened, such as a car accident that has claimed a life, but can't verify with law enforcement authorities. In this Internet age in which we live, people expect almost instantaneous news, but we're not in the business of reporting rumor and unverified accounts. We wait until reliable sources confirm the news before we publish.
Another situation that sometimes occurs is when something appears on Facebook that people take as the gospel truth. The account may contain a morsel of fact, but other parts may be embellished or plain wrong. Yet people start passing it along before verifying it's true.
We've dealt with that this week. A criminal incident that supposedly happened in northern Davidson County began spreading like wildfire. We had emails and calls asking about it. A call to the Davidson County Sheriff's Office revealed no prosecutable offense had taken place. I deliberately am being vague about the details, since we determined nothing occurred to warrant a story.
Some callers wondered why we hadn't published anything. Those readers believed what they had read on Facebook. Yet the facts didn't match up with what was being shared.
We work in the business of reporting the news. When we learn of a situation and confirm it, we will report it. We don't attempt to conceal news.
Many people have lost faith in the mainstream media, and I realize that sentiment exists. All I can do is attest to our motivations and objectivity and assure them that we investigate incidents that readers tell us about, just like law enforcement authorities. But we maintain certain standards that must be met before a story can be published.
Social media can help reporters do their jobs. It provides readers another way in which to communicate and makes the conversation more two-way. The Internet allows us to publish news quickly on our website, Facebook page and Twitter feed, such as the cancellations that took place Thursday with the forecasted winter precipitation.
But plenty of examples exist of things posted on social media and other websites that turned out to be false. I always tell folks to read them skeptically until they can be verified by a reliable source. And sometimes these stories do make it into the mainstream media, too.
I enjoy Facebook and keeping up with friends from here and afar. But I've learned to be careful when reading comments passed along without the poster's firsthand knowledge. The more sensational the news, the more skeptical I become.
Chad Killebrew is executive editor of The Dispatch. He can be reached at 249-3981, ext. 215, or at firstname.lastname@example.com.


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Pistorius Lawyer Attacks Testosterone Claim
Oscar Pistorius's lawyer challenged a claim that police found testosterone in the athlete's home after arriving to investigate the death of Reeva Steenkamp. Photo: Getty Images.
This transcript has been automatically generated and may not be 100% accurate.
... I ... he asked me out stories lawyer he's challenging claims of police and testosterone in at the town while investigating the shooting death of his girlfriend ... WSJ's Devon mainly was in court today in joins us now from Johannesburg South Africa ... By Devon thanks for being here a lot of back and forth in court ... about testosterone versus an herbal remedy what were the two attorneys debating what did they say ... well CNN's new humanism prosecutors said they found she couldn't do something he has testosterone along with Daniel ... is buying land in the ninety minute they know actually ... will they wanna see is not an anti next year so he ... can say that the ... teaching but as it confirmed that ... a lot of back and forth over some nitty gritty details at this bail hearing today I including ... the wayside and that the couple for sleeping on and whether they use their I Phones can you describe a little bit to us about that ... the answer is these ... pieces studios in medical science England's highlight detail about what happened in sch that a ... group annuity is dying ... I didn't get a ... lawyer for Mr. it is cleaning the it's yes ... and and and explain them to sustainable pollster found a gun ... on ... the Fed acts that it's been ... a bounce U I ... can not ... only has to say that he sees things he called an ambulance and lazy XD I ... see that it doesn't happen have yet ... to explain on this I'm also getting through to the town and the core and yesterday it was very emotional and in August that the story says ... I euro in many ways in South Africa is known as the blade runner ... for the J shaped carbon fiber prosthetic legs ... that he is used when racing on the track ... today did that emotion carry on ... seven ... she has a long one can ... say he's the guy and that it easily use that ... NetEase holding area I had in its thinking ... sch and any time since Daniel's alone when ... used in gas when he does agree to something that the prosecutor with an ... average ... investigator rein in another potential crime incident ... involving the story is can you tell us about the language he used in what he said there ... sch yes ... on the weakness signs and when I told him ... that a gun ... when he and Mr. it in January this year at a restaurant in Japan as it's known is ... that banks ... some strange things he contrasts that ... they had a pretty nice though he is and isn't it when you see and so on ... and that and very quickly when will we get a decision on the bail ... Ch ... my ... aunt and cousins in the land and in the limelight ... essentially decisions my ... are a Devon Maylie for us in Johannesburg South Africa following the OS with stories case


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GED Exam Practice Questions: GED Practice Tests & Review for the General Educational Development Test, by Mometrix Media
Note: Supplemental materials are not guaranteed with Rental or Used book purchases.
- Cover: Paperback
- Copyright: 3/31/2014
GED Exam Practice Questions are the simplest way to prepare for the GED test. Practice is an essential part of preparing for a test and improving a test taker's chance of success. The best way to practice taking a test is by going through lots of practice test questions. There is a tremendous advantage to someone taking the test that is already familiar with the questions and answer choices. Another advantage of taking practice tests is that you can assess your performance and see if you need to study and practice more, or if you're already prepared enough to achieve success on your test day. Taking lots of practice tests helps ensure that you are not surprised or disappointed on your test day. Our GED Exam Practice Questions give you the opportunity to test your knowledge on a set of questions. Repetition is a key to success and using practice test questions allows you to reinforce your strengths and improve your weaknesses. Detailed answer explanations are also included for each question. It may sound obvious, but you have to know which questions you missed (and more importantly why you missed them) to be able to avoid making the same mistakes again when you take the real test. That's why our GED Exam Practice Questions include answer keys with detailed answer explanations. These in-depth answer explanations will allow you to better understand any questions that were difficult for you or that you needed more help to understand.


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Supporters are now helping to
Campaign closed
Family Court Judges are operating outside of their judicial role when they present themselves as experts in areas other than law. Reform is needed on many levels, especially in the legal and psychological management of Parental Alienation cases. Targeted parents, especially fathers, start off at a disadvantage because the Family Division remains bias, working within the broken context of VAWA…
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Nissan Hosts Family Garden Party +VIDEO
• SEE ALSO: Nissan Buyers Guide
NASHVILLE, TN - July 10, 2014: Nearly every vehicle in the current Nissan lineup, plus a few eye catching vintage and test vehicles, was on display in Nashville for an expansive media drive program this week. It was held at a mansion in Belle Meade, Tennessee, at what was the set for the pilot of the "Nashville" TV series.
"This event is absolutely brilliant because not only does it give access to the media to our full lineup, but also to things that we may want to have their feedback on. Today we have the European Nissan Qashqai diesel. We have the Nissan Micra, which we sell in Canada but not the U.S. We have new technologies – some we are looking at like Smart Rearview Mirror. Some ones we are just beginning to study, like the World's Cleanest Car, the Nissan LEAF, with the Nano paint technology," said Pierre Loing, vice president, Nissan Product Planning.
Nissan's product and marketing teams provided product walk-arounds and ride-alongs with media. The goal? Celebrate one of the freshest Nissan lineups in recent history and provide a glimpse at what is just over the horizon.
"The all-new generations of the five core models that we have launched are very successful. You see that Rogue is on fire. You see Versa and Versa Note being leaders of their segment with over 20 percent market share. The 25 percent remaining starts with the new Murano. At the Detroit show, we'll unveil the new Titan, and then the new Maxima," said Loing.
Media from throughout the U.S. and Canada attended this special event in Nashville. All had a chance to drive and to admire what is the true sense of Nissan's passion for design, driving and innovation – a brand on the rise.
"It has been fun to test a lot of the cars in this context. We also got to see a lot of models that are not necessarily available here for instance, the Qashqai, so that was interesting. Also, the older models, the classic ones – it was a good opportunity to discover the Nissan product," said Sabrina Giacomini of autogo.ca.
"It's a great opportunity to taste all of the cars in the lineup. It allows us in one day to test all of the cars. I get a really good idea of the capabilities, the handling, the ride, the quality, the workmanship of all of the cars in the lineup," said Neil Vorano of Canada's The Globe and Mail.
And the most popular vehicle?
"The most popular vehicle that the journalists have taken out? There are really a couple of them. One of them is a 1965 pick-up truck. They love driving that, but also the NISMO GT-R. GT-R is always a favorite, but this one especially," said Steve Parrett, Nissan Corporate Communications.


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Learn all there is to know about sake with a Certified Sake Professional.
As we weave through the cobbled streets of Toronto's historic distillery district, we'll discuss how a simple mill evolved into the world's largest distillery. Soak in the beauty of the district as is stands today.
Next stop in at SOMA Chocolate Maker's, one of the first shops to open the area for some tasty drinking chocolate. Spicy or Classic- Your choice!
Lastly we'll return to Izumi, the first sake brewery in Canada. Meet the brewers, learn about how sake is made, and get a strong taste of sake culture. As we sample loads of sake, you can taste traditional Japanese bar snacks. By the end you'll have learned to identify the styles and flavours like a pro.
Tour Includes:
- Expert Guide with Sake certification
- Drinking Chocolate from SOMA
- Sake brewery tour with 5-part tasting
- Traditional Japanese Bar Snacks


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Andrew Jordan, vice president of technical services for the National Cotton Council, has been declared an honorary "Extension Cotton Specialist." The honor was bestowed on Jordan by the country's cotton specialists at their annual meeting during the 2007 Beltwide Cotton Conferences in New Orleans.
J.C. Banks, cotton specialist for Oklahoma State University, made the presentation saying, "The Extension cotton specialists recognize and applaud Dr. Andrew Jordan for his dedication, vision, and expertise in furthering and serving the U.S. cotton industry."
Jordan has worked with the NCC for more than 30 years and is retiring next month. His depth of technical knowledge and breadth of experience with the seven segments of the cotton industry has proven beneficial for the entire industry. During his tenure at the NCC, he has led educational efforts in the industry, including significant work in numerous areas of cotton production, among them physiology, insect control, biotechnology, technology transfer and stewardship.
Louisiana Cotton Specialist Sandy Stewart said the group of specialists agreed Jordan was particularly deserving of the honorary specialist designation due to his constant support of the specialists in the past few decades. He added that the timing of the 2007 Beltwide specialists meeting, sponsored by Delta and Pine Land Co., was an easy choice as the venue for bestowing the honor as Jordan's retirement is imminent.
"Andy has worked with our group on so many occasions that we almost immediately knew this was the best way for us to tell him thank you," Stewart said.
About 20 cotton specialists provide cross-discipline services (physiology, weed and insect control, etc.) to growers across the U.S. Cotton Belt.


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Tuesday, May 5, 2015
Episode of the Avengers with guest appearance by Spider-man.
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Mike Wetterhahn
Currently in L.A. working at Dreamworks T.V. on "Puss In Boots". Previously worked at Starz/Film Roman on "Ultimate Spider-Man". Prier to that worked at The Third Floor on various movies like X-Men: Days of Future Past. While in N.Y. worked for J.J. Sedelmaier Prod., Stretch Films, T.V. Funhouse, Cartoon Network, 4 Kids Ent, Wachtenheim and Marianetti and Animation Collective. I've worked on such shows as Courage the Cowardly Dog, Stanley, Saturday Night Live and Teenage Mutant Ninja Turtles "Fast Forward". (914) 575-9511 email@example.com
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Reeling Huskies Lose to Ducks at Home
SEATTLE (AP) — Johnathan Loyd scored all 11 of his points in the second half, Damyean Doston finished with 13 and No. 23 Oregon snapped a two-game road losing streak with a 65-52 win over Washington on Wednesday night. The Ducks (20-5, 9-3 Pac-12) had dropped three of four, losing their grasp on sole possession of first place in the conference. They regained it for at least for 24 hours, moving a half-game ahead of Oregon and UCLA, who both play on Thursday night. Oregon played its sixth straight game without Dominic Artis, out with a foot injury. The Ducks continued to stumble offensively without their starting point guard, but their defensive effort was enough to hand Washington its seventh loss in eight games. It was the first time Oregon has swept Washington in the regular season since 1995. Abdul Gaddy led Washington (13-12, 5-7) with 17 points.
Associated Press