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Polar Vortex Cowl by Crochet by Jennifer
patterns > Crochet Style: Over 30 Trendy, Classic and Sporty Accessories for All Ages and 1 more...
> Polar Vortex Cowl
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© AppleTree Photography
© AppleTree Photography
This book contains 32 patterns$14.95 on Amazon look inside this book!
Polar Vortex Cowl
This pattern is available for $4.95 USD buy it now
This pattern is included in my book Crochet Style. The book contains 32 patterns (27 brand new designs) and is a great savings! Save money by ordering your copy today (click on the link above)!
This is a PDF crochet pattern for a chunky cowl that coordinates perfectly with my Polar Vortex Beanie, Fingerless Gloves, and Boot Cuffs.
Skill Level: Intermediate
All of my patterns are written in U.S. Standard Crochet Terminology and in English only.
You are welcome to sell all finished items from this pattern. When selling items online, a link to this pattern is appreciated but not required.
Due to the nature of patterns, there are no returns or refunds. All sales are final. Help is available by email, link is included in pattern.
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The inherent trashiness of Reform School Girl is redeemed by the sincere performance of Gloria Castillo and the matter-of-fact direction of Edward Bernds. Castillo plays mixed-up teenager Donna Price, who is shipped off to a girl's reformatory when she is involved in a fatal car crash. Actually, Donna is innocent, but she refuses to reveal who was driving.
Only when the culprit (a pre-77 Sunset Strip Edward Byrnes) reveals himself to be a total piece of excrement is Donna able to extricate herself from her dilemma. The film served as the movie debut of Sally Kellerman, cast as a butchy inmate. Reform School Girl was remade for television in 1994 as part of Showtime cable's Rebel Highway series.


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Jaipur, Feb 19 (IANS) A Sukhoi Su-30 fighter jet of the Indian Air Force crashed in the Pokhran range in Rajasthan's Jaisalmer district Tuesday but the two pilots bailed out safely, officials said.
Defence spokesperson Col. S.D. Goswami said that the aircraft crashed at about 7.20 p.m.
"The aircraft was on a night-flying training mission," Goswami told IANS.
He said there was no reported damage to life or civil property.
The spokesperson said a court of inquiry had been ordered into the crash.
Sources said the aircraft was to participate in IAF's day-night exercise 'Iron Fist' on Feb 22. They said a rehearsal of the exercise was held Tuesday.


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Friday ReadsPosted: January 25, 2013 Filed under: morning reads, U.S. Politics, War on Women, Women's Healthcare | Tags: abortion rights, Bobby "Crazy" Jindal, dung balls, dung beetles, Filibuster Reform, Mary Jo White, rape, Reid, Republicans, SEC, wimp 46 Comments
I really don't intend this to be a post about Republican crazy but we're going to start out with that subject. Let's hope this post morphs into something else by the time I'm done.
Apparently it took a female Republican to come up with the most vicious way to punish women who had the audacity to get themselves raped.
Wednesday, state representative Cathrynn Brown of New Mexico introduced a bill whose sheer audacity makes Todd Akins look as harmless as an ill-informed teenager groping his way through puberty.
The proposed legislation, House Bill 206, would make it illegal for a woman to have an abortion after being raped because the fetus is evidence of the crime. A women who does choose to have an abortion would be charged with the third-degree felony of "tampering with evidence," which carries up to a three year prison sentence in New Mexico.
As the bill states:
"Tampering with evidence shall include procuring or facilitating an abortion, or compelling or coercing another to obtain an abortion, of a fetus that is the result of criminal sexual penetration or incest with the intent to destroy evidence of the crime.
In other words, Brown just said to rape victims: give birth to this baby or you'll go to jail.
Crazy Louisiana Governor Bobby Jindal says the "GOP is a populist party' and is the party of the middle class. Whoa, something in that exorcism must be causing him to have some kind of flash back. Here's Tiger Beat on the Potomac:
"We must quit 'big,'" he said. "We are not the party of big business, big banks, big Wall Street bailouts, big corporate loopholes or big anything. We must not be the party that simply protects the well off so they can keep their toys … We are the party whose ideas will help the middle class, and help more folks join the middle class."
He called repeatedly for a reorienting of the party's focus from the Beltway to state capitols.
"We believe in planting the seeds of growth in the fertile soil of your economy, where you live, where you work, invest, and dream, not in the barren concrete of Washington," he said. "If it's worth doing, block grant it to the states. If it's something you don't trust the states to do, then maybe Washington shouldn't do it at all. We believe solving problems closer to home should always be our first, not last, option."
Well, he did explain one of the ways he's made everything worse down here along with that call out to states being able to do what ever they want which sounds remarkably like returning reinstating Jim Crow and expanding Jane Crow.
The Louisiana governor suggested "re-thinking nearly every social program in Washington" in a speech to members of the Republican National Committee gathered here.
"If any rational human being were to create our government anew, today, from a blank piece of paper – we would have about one fourth of the buildings we have in Washington and about half of the government workers," he said, according to a copy of the speech obtained in advance by POLITICO. "We would replace most of its bureaucracy with a handful of good websites."
I've been caught in one of his website hells as well as the result of his passion for getting rid of every service that a government more efficiently provides. Things have been replaced by endless phone trees and decidedly unhelpful websites. It ain't pretty or compassionate. It's more like being thrown into Somalia.
So, here's a good time to talk about some interesting facts about Dung Beetles. This is from the National Geographic which should send out a crew to figure out if there's any sign of intelligent life in Republican held state houses through out the country. Dung Beetles evidently have a keener sense of the right way to go than Republicans as they navigate via the Milky Way.
Talk about star power—a new study shows that dung beetles navigate via the Milky Way, the first known species to do so in the animal kingdom.
The tiny insects can orient themselves to the bright stripe of light generated by our galaxy, and move in a line relative to it, according to recent experiments in South Africa.
"This is a complicated navigational feat—it's quite impressive for an animal that size," said study co-author Eric Warrant, a biologist at the University of Lund in Sweden.
Speaking of moving balls of dung around, Senate Majority Leader Harry Reid has wimped out on Filibuster reform.Senate Majority Leader Harry Reid and Senate Minority Leader Mitch McConnell have come to a deal on filibuster reform. The deal is this: The filibuster will not be reformed. But the way the Senate moves to consider new legislation and most nominees will be. Here's an explanation from Beltway Bob errrr Ezra Klein.
What will be reformed is how the Senate moves to consider new legislation, the process by which all nominees — except Cabinet-level appointments and Supreme Court nominations — are considered, and the number of times the filibuster can be used against a conference report. You can read the full text of the compromise, which was sent out to Senate offices this morning, here (pdf).
But even those reforms don't go as far as they might. Take the changes to the motion to proceed, by which the Senate moves to consider a new bill. Reid seemed genuinely outraged over the way the process has bogged down in recent years.
"What the Republicans have done is turn the motion to proceed on its head," he argued. "It was originally set up to allow somebody to take a look at a piece of legislation. What the Republicans have done is they simply don't allow me to get on the bill. I want to go to it on a Monday, they make me file cloture, that takes till Tuesday. Then it takes two days for the cloture vote to 'ripen,' so now it's Thursday, and even if I get 60 votes, they still have 30 hours to twiddle their thumbs, pick their nose, do whatever they want. So, I'm not on the bill by the weekend, and in reality, that means next Monday or Tuesday."
But the deal Reid struck with McConnell doesn't end the filibuster against the motion to proceed. Rather, it creates two new pathways for moving to a new bill. In one, the majority leader can, with the agreement of the minority leader and seven senators from each party, sidestep the filibuster when moving to a new bill. In the other, the majority leader can short-circuit the filibuster against moving to a new bill so long as he allows the minority party to offer two germane amendments. Note that in all cases, the minority can still filibuster the bill itself.
Mary Jo White has been appointed to head the Securities and Exchange Commission (SEC) by President Barack Obama.
Currently the head of litigation at Debevoise & Plimpton, a private law firm, Ms White will add a female voice to Mr Obama's second-term team, which is so far dominated by men. More importantly, the former federal prosecutor for the Southern District of New York has experience policing Wall Street, which fell under her jurisdiction. Mr Obama has slammed bankers for their role in the financial crisis and ensuing recession. The choice of Ms White seems to signal his resolve in getting tough with the banks.The appointment is not without controversy. Ms White has benefited from the revolving door between public service and private practice. In the aftermath of the crisis, financial firms sought the assistance of former regulators with strong ties to the government. In a scathing article on Bloomberg's website, Jonathan Weil notes that Ms White participated in the defence of many people and institutions at the heart of the financial collapse. In October 2008 she was cited in a critical report by the SEC's inspector general for receiving "relevant information" that was not publicly available. Some will ask whether she is truly a poacher turned gamekeeper or simply setting herself up for another lucrative turn through the revolving door.Mr Obama, for one, is convinced he is getting the "tough-as-nails prosecutor". By putting Ms White at the SEC, he has suggested that the agency's priority is enforcement. But a bigger challenge may come from the sprawling Dodd-Frank legislation, and its many gaps and contradictions. Much of the next chairman's time should be devoted to rethinking how America's capital markets are structured, and deciding how that vision will be translated into the numerous rules the SEC is required to write under Dodd-Frank's sloppy mandates. Ms White, in other words, has a big job ahead of her.
Well, today's post sorta took an interesting turn didn't it? It went from crazy Republicans to wimpy Democrats with one little mention of the only smart and honest shit pusher in between. Well, at least the pictures are fun to look at.
What's on your blogging and reading list today?


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Selfpics of a really hairy teen beaver. She wanted to know what you all thought of her 19 year old body so let her know.-18
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Description: This free porn embodies teen_18 free porn, but wait till you see the album.
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For carrying out section 301 and title IV of the PHS Act with respect to human genome research, [$513,844,000] $511,370,000 (Department of Health and Human Services Appropriations Act, 2012.)
|Sources of Funding
|FY 2011 Actual
|FY 2012 Enacted
|Type 1 Diabetes
|Subtotal, adjusted appropriation
|Real transfer under Director's one-percent transfer authority (GEI)
|Real transfer to under Secretary's transfer authority
|Comparative Transfers for NCATS organization
|Comparative Transfers to NCATS for Therapeutics and Rare and Neglected Diseases (TRND)
|Comparative transfer to NLM for NCBI and Public Access
|Subtotal, adjusted budget authority
|Unobligated balance, start of year
|Unobligated balance, end of year
|Subtotal, adjusted budget authority
|Unobligated balance lapsing
|Total obligations
1/ Excludes the following amounts for reimbursable activities carried out by this account:
Excludes $157 in FY 2011; $122 in FY 2012; and $131 in FY 2013 for royalties.
1/ All items in italics are "non-adds"; items in parenthesis are subtractions
FTTP = Full-time training positions
FTE = Full-time equivalent
Major changes by budget mechanism and/or budget activity detail are briefly described below. Note that there may be overlap between budget mechanism and activity detail and these highlights will not sum to the total change for the FY 2013 President's Budget request for NHGRI, which is $0.893 million less than the FY 2012 Enacted level, for a total of $511.4 million.
In keeping with the vision articulated in NHGRI's 2011 strategic plan, as well as a desire to report NHGRI's research activities in a more holistic manner (one that includes an integrated view of intramural and extramural research activities), the institute has changed the reporting of Budget Authority by Activity in the Congressional Justification for FY 2013. Intramural and Extramural research activities are now grouped by their place within the Strategic Plan's five domains and three crosscutting elements (plus Intramural Research and Research Management Support):
1. Inlcudes FTEs which are reimbursed from the NIH Common Fund.
2. Includes Real Transfer and Comparable Adjustments as detailed in the "Amounts Available for Obligation" table.
* The detail programs listed above include both extramural intramural funding.
Section 301 and title IV of the Public Health Service Act, as amended.
FY 2011 Actual
Program funds are allocated as follows: Competitive Grants/Cooperative Agreements; Contracts; Direct Federal/Intramural and Other.
The National Human Genome Research Institute (NHGRI) funds and conducts research to advance knowledge about the genomic underpinnings of disease and to establish how genomic information can be used to improve the diagnosis and treatment of disease. As described in NHGRI's new strategic plan for genomics research published in the journal Nature 1 in February 2011, it is an extraordinary time for biomedical research in general and genomics research in particular. In FY 2013, NHGRI will capitalize on the remarkable opportunities afforded by prior research investments to advance our understanding of genome biology and to begin translating genomic science into genomic medicine on a broader scale than was previously possible.
NHGRI's 2011 strategic plan identifies five distinct domains that together comprise a progressive continuum of research endeavors. This continuum begins with fundamental basic research to understand the structure of genomes, the biology of genomes, progresses to include the use of genomics to understand the biology of disease, to advance medical science, and to improve the effectiveness of healthcare.
In FY 2013, NHGRI is increasing its research efforts to apply basic knowledge about the structure and function of the human genome to the third research domain — investigating the genomic basis for human disease. In the future, the focus will expand toward translating new insights about disease into genomic-based clinical advances.
Genomic Science: Many of the most impressive genomic advances in the past decade have been fueled by NHGRI's long-term investment in technology development aiming to reduce the cost of DNA sequencing. NHGRI set a goal to reduce the fully loaded cost of generating a high-quality human genome sequence to $25,000 by the end of FY 2011 — a 40,000-fold reduction over what the Human Genome Project accomplished in 2003. By end of FY 2011, even this ambitious goal was surpassed, with a sequenced human genome costing approximately $ 7,700. The extraordinary advances in DNA sequencing technologies are accelerating discoveries across all areas of biomedical research and are now invigorating genomics-oriented translational research.
The Large-Scale Genome Sequencing Centers supported by NHGRI for many years remain a prominent and vital part of the Institute's research portfolio. These centers conduct genomic studies in support of NHGRI flagship programs, such as The Cancer Genome Atlas (TCGA, which explores the genomic basis underlying different types of cancer) and the 1000 Genomes project (which aims to improve our understanding of human genomic variation). These Centers will increasingly conduct collaborative research projects with other investigators, providing the opportunity to broaden the application of the sequencing centers' technologies and expertise in the pursuit of important and cutting-edge research questions.
In addition to continuing highly successful programs like TCGA, NHGRI is expanding its application genome sequencing to include new large-scale studies of rare, Mendelian (single-gene) diseases through the establishment of Mendelian Disorders Genome Centers. These new Centers will seek to discover the genomic basis for thousands of Mendelian disorders that affect approximately 25 million Americans.
Genomic Medicine: NHGRI's expansion into more translational genomics research is still in a relatively early phase. The Electronic MEdical Records and GEnomics (eMERGE) Network is integrating genomic information into electronic medical record systems and investigating how this information can be used by healthcare providers to improve clinical care. For example, genomic data could help identify patients who would benefit from increased monitoring for specific conditions and/or from a tailored selection of drug treatments to enhance effectiveness and reduce adverse reactions.
As an extension of NHGRI's broader Large-Scale Genome Sequencing Program, a new Clinical Sequencing Exploratory Research program aims to study how best to apply genome sequencing in clinical settings. These investigator-initiated projects will apply the foundational knowledge, skills, and practices gained from prior NHGRI genome-sequencing activities to the care of individual patients — bridging the gap between genomic discoveries and patient care. These projects will also integrate genomic, clinical, and psychosocial research components, with the latter being important for understanding the attitudes and social consequences associated with the implementation of genomic medicine.
Fundamental to the success of the research continuum detailed in NHGRI's 2011 strategic plan are three cross-cutting elements: Bioinformatics and Computational Biology, Education and Training, and Genomics and Society. NHGRI is committed to its investment in these areas, as each is crucial to realizing the Institute's long-term vision for genomics. The benefits of genomic medicine will only be realized if there are robust bioinformatic and computational tools for manipulating the large data sets generated by high-throughput genomic methods; a workforce with the requisite interdisciplinary skills and training; and a public ready to embrace new genomic knowledge about themselves as an element of their clinical care.
Genomics and the Economy:In addition to improving human health, the federal investment in genomics research is also a stimulant for the U.S. economy. The independently commissioned Battelle report (2011) 2 showed that every dollar invested by the U.S. Government in genomics has generated $141 in the nation's economy. In 2010 alone, the genomics sector directly supported more than 51,000 jobs and indirectly supported another 310,000, adding $67 billion to the U.S. economy (including $20 billion in personal income).
While the full potential of enhancing Americans' health through the application of genomics will not be realized for many years, research and investment in this field of biomedical research is already significantly benefiting the nation. By pursuing the genomics research agenda detailed in NHGRI's 2011 strategic plan, not only will the financial benefits continue, but they will be further enhanced in the long run as a byproduct of genomics positive impact on medicine.
Overall Budget Policy: The FY 2013 President's Budget request for NHGRI is $511.4 million, a decrease of $0.893 million or -0.17 percent less than the FY 2012 Enacted level. Funds are included in R&D contracts to support trans-NIH initiatives, such as the Basic Behavioral and Social Sciences Opportunity Network (OppNet).
1. Green ED, Guyer MS, and National Human Genome Research Institute. (2011). Charting a course for genomic medicine from base pairs to bedside. Nature, 470(7333): 204-213. Available at http://www.genome.gov/Pages/About/Planning/2011NHGRIStrategicPlan.pdf.
2. http://www.battelle.org/publications/humangenomeproject.pdf
Understanding the Structure of Genomes: Understanding the structure of genomes remains fundamental to NHGRI's research portfolio. The Institute's DNA Sequencing Technology Development Program is among its most successful endeavors to date, supporting the design of a wide variety of methodological approaches to DNA sequencing since its inception in 2003. As a result, the fully loaded cost of sequencing a human genome has fallen by many orders of magnitude, quickly approaching the 10-year goal set in 2004 of $1,000.
Other NHGRI research activities in this domain include the 1000 Genomes project, which has benefited from ever-decreasing DNA sequencing costs and is now analyzing the genomes of about 2,500 people from 27 populations around the world; these efforts are providing key information about millions of genomic variants, information which is important to identifying the genetic causes of disease. The catalogued variants range from single-base differences among people to large genomic insertions and deletions, and these reflect both rare variants as well as common ones. A small subset of these variants contributes to an increased risk (or protection) for specific diseases and to differences in drug response. The data from the 1000 Genomes project is accelerating the field of human genetics, and many researchers are already using the ever-growing informational resource created by the project for their disease studies. There is clear evidence that these efforts are leading to the successful identification of genetic mutations accounting for both rare and common diseases. The 1000 Genomes data are also being used to develop affordable technologies for individual genome analysis, which will eventually enable physicians to predict a person's risk for various diseases and to choose effective drugs and drug dosages.
Budget Policy: The FY 2013 President's Budget request for Understanding the Structure of Genomes is $67.5 million, a decrease of $0.144 million or 0.21 percent less than the FY 2012 Enacted level. The activity in Understanding the Structure of Genomes will continue NHGRI's signature efforts to decrease the cost of DNA sequencing and the 1000 Genomes Project. NHGRI will continue in FY 2013 its ground-breaking efforts to reduce the cost of DNA sequencing so that this technology, which has increasingly become central to biomedical research, can become a widely disseminated research tool and, beyond that, a tool for clinical application and individual healthcare. Additionally, in FY 2013 this program will continue with the full-scale implementation of the 1000 Genomes Project. New directions will include the analysis of the role of variation in understanding gene expression. The Institute also will continue to fund meritorious investigator-initiated applications submitted in response to announcements that encourage new technologies and new approaches to the analysis of genome structure, and the role that genome structure plays in the determination of human disease, disease susceptibility, and environmental sensitivities.
Understanding the Biology of Genomes: Since completion of the Human Genome Project, NHGRI-funded research has continued to lead the field of genomics by studies that expand our understanding of human genome function. The ENCyclopedia of DNA Elements (ENCODE) project (which is focused on the human genome) and the companion modENCODE project (which uses the same approach on a few select model organisms) have successfully generated a wealth of data about the functional elements in genomes, such as genes and sequences that turn those genes on or off at the proper times during development and in the proper cell types. This information is critical to understanding normal biological processes and the perturbations in biological pathways that manifest in disease.
NHGRI's Centers of Excellence in Genomic Science (CEGS) program supports interdisciplinary research efforts that have been instrumental in developing new ways to use genomic approaches to derive novel biological and biomedical insights. The CEGS will continue to develop and test new approaches for producing, analyzing, and using genomic data. They will also generate new insights into how genomes function and how genomic variants among individuals influence that function. The U.S. biomedical research enterprise will continue to benefit from this investment as genomic tools, techniques, and trainees make their way from the CEGS to the broader biomedical research community.
Budget Policy: The FY 2013 President's Budget request for Understanding the Biology of Genomes is $113.7 million, a decrease of $0.219 million or 0.19 percent less than the FY 2012 Enacted level. In FY 2013, NHGRI will continue to support the CEGS program in its efforts to stimulate highly innovative research approaches that will substantially advance genomic approaches to the study of a biological problem, and to foster the wider application of comprehensive, high-throughput genomics methods to the study of human biology and disease. The Institute also will continue to fund meritorious investigator-initiated applications submitted in response to announcements that encourage new technologies and new approaches to the analysis of genome biology.
Using Genomics to Understand the Biology of Disease: NHGRI's research portfolio is expanding its focus on utilizing genomics to better understand the biology of disease, as described in the Institute's 2011 Strategic Plan. This research builds upon work conducted in the above two programs and will be used to inform scientists working in more translational areas. NHGRI's Large-Scale Genome Sequencing Program has shifted its major focus from sequencing the genomes of many different organisms to provide data for comparative genomic analyses to sequencing large numbers of human genomes as part of large disease studies.
Genome-wide association studies (GWAS) have identified many genetic variants related to common diseases, as disseminated by the online NHGRI GWAS Catalog. To date, most of these studies have been performed in populations of European origin; further exploration in non-European populations is critical for the entire population to benefit from such research. The Population Architecture using Genomics and Epidemiology (PAGE) project is a consortium of U.S. studies that analyzes relationships between genetic variants and a range of common diseases and traits in well-characterized populations. Importantly, PAGE includes approximately 100,000 study participants to investigate whether these genetic associations are generalizable to non-European individuals or if they are modified by lifestyle or other factors. NHGRI is also creating tools that investigators can use to expand GWAS efforts beyond their primary genetic research focus. The Consensus Measures for Phenotypes and eXposures (PhenX) project is creating a toolkit that provides standard measures related to complex diseases, phenotypic traits, and environmental exposures; these standards have been largely lacking until now.
NHGRI's Intramural Research Program is also supporting research to advance our knowledge of the genetic contributors to disease. For common diseases, the ClinSeq project is examining the clinical strategies that will be needed for widespread genome sequencing in a clinical context, initially focusing on cardiovascular disease. At the other end of the spectrum, rare diseases are the focus of the Undiagnosed Diseases Program (see program portrait), which draws on the resources and wealth of expertise at the NIH Clinical Center to address medical mysteries, ideally arriving at diagnoses or possible treatment options for patients whose conditions have stumped medical experts.
Budget Policy: The FY 2013 President's Budget request for Using Genomics to Understand the Biology of Disease is $139.9 million, a decrease of $0.249 million or 0.18 percent less than the FY 2012 Enacted level. The Institute will continue to fund meritorious investigator-initiated applications that will increase the ability of genomics to have a major impact on the progress of biomedical and translational research.
FY 2012 Level: [$3.5 million]
FY 2013 Level: [$3.5 million]
Change: [$0 million]
The Undiagnosed Diseases Program (UDP) is a trans-NIH initiative with programmatic and administrative support from NHGRI, the NIH Clinical Center, and the NIH Office of Rare Diseases Research. In February 2011, three years after its launch, the program reported its first diagnosis of a new rare disease in the New England Journal of Medicine.*
The UDP has two goals — to provide answers to patients with mysterious conditions that have long eluded diagnosis and to advance medical knowledge about human diseases. Patients are referred to the UDP by their clinicians and, if accepted, travel to the NIH Clinical Center in Bethesda. There, a team of medical and scientific experts conducts a multi-day, comprehensive clinical work up; this that includes consults from numerous senior physicians with expertise in medical specialties from across NIH institutes and centers, including endocrinology, immunology, oncology, dermatology, dentistry, cardiology, and genetics. Not all of the patients accepted into the UDP will receive a diagnosis, but cases are chosen that offer a reasonable potential for NIH doctors to identify a previously unrecognized rare disease, suggest new ways to treat that illness, and/or determine promising options for continued research.
The UDP team is exceptionally dedicated, reviewing approximately 140 applications a month and seeing 180 patients a year for intensive weeklong evaluations. In fact, the UDP has received such an overwhelming response that in July 2011, the program had to suspend accepting new applications temporarily in order to allow the team to work through the backlog of several hundred cases.
The program has captured the imagination of the public, and has been featured in numerous media reports. William Gahl, M.D., Ph.D. — NHGRI's Clinical Director and the founding Director of the UDP — and the UDP team have won a number of prestigious awards as a result of their work.*St Hilaire, et al. (2011). NT5E Mutations and Arterial Calcifications. The New England journal of medicine, 364(5), 432–442. doi:10.1056/NEJMoa0912923
Using Genomics to Advance Medical Science: With increasing frequency, genomic information in the form of individual patient's personal genome sequences will be used to guide physicians' therapeutic decisions and to improve the practice of medicine. Work in this research domain is still at an early stage, but significant advances are anticipated in the coming decade. The widespread use of genome sequencing as a clinical tool will require more than just clinically affordable genome sequencing methods. Rather, sequencing a patient's genome, analyzing the resulting data, and then providing the relevant genomic information in an easy-to-understand format to his/her healthcare provider (who most likely will not be an expert in genomics) will require new developments at multiple levels, involving many different aspects of NHGRI's research portfolio.
To anticipate these needs, the Institute is beginning to fund translational research that will facilitate the application of genomics to clinical care. This work is exemplified by the recently launched Clinical Sequencing Exploratory Research program, which began in FY 2012. This program is a valuable 'test bed' for exploring and developing the capacities necessary to obtain a patient's whole-exome sequence (just the protein-coding components) or whole-genome sequence (the entire genome) and to derive the necessary information for enhancing clinical decision-making. The collaborative nature of this program will facilitate the development, standardization, and integration of best practices and common approaches for clinical genome sequencing. Integral to the specific projects in this program are studies examining the significant bioethical issues relevant to acquiring large amounts of genome sequence data from patients as part of their medical care, to deciding what genomic findings to return to patients, and to deciding when and how to communicate such findings to patients and their families.
Budget Policy: The FY 2013 President's Budget request for Using Genomics to Advance Medical Science is $19.9 million, a decrease of $0.020 million or 0.10 percent less than the FY 2012 Enacted level. Medical sequencing continues to be an area of growth for NHGRI. With large-scale sequencing now completely transitioned to the next-generation sequencing instruments, many new opportunities have been created to apply genomic tools to the study of human disease and the application of that information to the development of new approaches to disease management. Many of the new opportunities will be pursued in collaboration with other NIH ICs.
FY 2012 Level: [$9.5 million]
FY 2013 Level: [$9.5 million]
Change: [$0 million]
The cost and time needed to sequence a human genome has decreased precipitously since the completion of the Human Genome Project in 2003, and it is now feasible to use high-throughput DNA sequencing as a diagnostic tool in certain clinical settings. At the same time, because of advances in genomics research more broadly, scenarios can realistically be envisioned whereby whole-genome sequencing may become a routine component of medical care in the coming years. Indeed, there have been a number of recent cases in which genome sequencing has been used both to identify the genetic cause of a disease and to guide a patient's treatment. For example, an unresolved case of extreme inflammatory bowel disease threatened the life of a 4-year-old boy until genome sequencing identified his underlying mutation, leading to a change in his treatment that probably may have saved his life.
The integration of state-of-the-art genome-analysis technologies into clinical practice is nevertheless still in its infancy. A tremendous amount still needs to be learned about how to overcome barriers to adopting these technologies and how to integrate them in a way that maximizes their clinical utility. Also needed are studies that rigorously explore the many ethical and social issues that will arise upon the widespread introduction of genome sequencing in medical settings.
To address these needs, NHGRI has launched the Clinical Sequencing Exploratory Research program, a new component of the Institute's Large-Scale Genome Sequencing Program. The new projects, which began in FY2012, are looking at the myriad critical aspects of integrating genomics into patient care, including how to provide meaningful genomic information to healthcare providers, how to integrate genomic data into health records, and how to give appropriate informed consent and subsequently genomic results to patients.
Using Genomics to Improve the Effectiveness of Healthcare: Using genomics to improve the effectiveness of healthcare is the most patient-relevant of the five research domains described in the 2011 NHGRI strategic plan. A robust research portfolio in this area requires a broad foundation built upon research accomplishments within the first four domains; it may not be until the next decade that we see a significant proportion of NHGRI's research initiatives focusing on this domain. Even at this very early stage, however, NHGRI is funding research in this area, notably within the Electronic MEdical Records and GEnomics (eMERGE) Network. Currently consisting of a seven-member consortium of research centers and heathcare providers, eMERGE is investigating the integration of patients' genomic information with their electronic medical records. The combined phenotypic and genomic information enables novel approaches to clinical research as well as to the patient's ongoing clinical care. The eMERGE Network is also exploring the complex ethical, legal, and social issues involved with the use of electronic medical records for genomics research and developing best practices for data sharing.
Budget Policy: The FY 2013 President's Budget request for Using Genomics to Improve the Effectiveness of Healthcare is $11.7 million, a decrease of $0.014 million or 0.12 percent less than the FY 2012 Enacted level. NHGRI will continue in FY 2013 to support this area of research as the combination of advances in genomics with cutting-edge approaches to population studies remains of very high programmatic interest as an important strategy for addressing problems of using genomics to improve healthcare. The Institute also will continue to fund meritorious investigator-initiated applications, and to collaborate with other NIH Institutes/Centers in the area of translational genomics.
Bioinformatics and Computational Biology: As a result of NHGRI's DNA Sequencing Technology Development Program, genome sequencing is now cheaper and faster than ever, with improvements to streamline and enhance available methodologies continuously being developed and implemented. Although further cost reductions are desired, the major bottleneck in genomics is no longer the generation of sequence data. Rather, it is the challenge of computationally analyzing all of these data because of the nature of contemporary genomics, which is now regarded as "data-intensive research." The challenging elements include managing and storing large data files, analyzing the primary data to extract the essential genomic information, and visualizing the data in ways that minimize the burden on the researcher. NHGRI is funding bioinformatics and computational researchers through both unsolicited awards and more focused programs, such as the Informatics Tools for High-Throughput Sequence Data Analysis program and related projects. The goals for this area of the Institute's research portfolio include:
Budget Policy: The FY 2013 President's Budget request for Bioinformatics and Computational Biology is $81.9 million, a decrease of $0.160 million or 0.19 percent less than the FY 2012 Enacted level. Activity in Computational Genomics will remain essentially constant, maintaining the proportion of the NHGRI extramural budget devoted to this area. Effort will be directed to increasing the efficiency of data storage and distribution mechanisms, as the amount of data that needs to be processed has increased significantly with the introduction of next-generation sequencing and other new genomic technologies. In FY 2013, NHGRI will continue its support for the essential biomedical research resource represented by genomic databases. The Institute also will continue to fund meritorious investigator-initiated applications submitted in response to announcements that encourage new technologies and new approaches to the rapidly emerging issue of public access to large genomic datasets.
FY 2012 Level: [$82.1 million]
FY 2013 Level: [$81.9 million]
Change: [- $0.2 million]
NHGRI's past investments and continuing strong commitment to supporting research on new DNA sequencing technologies continue to pay great dividends across the entire NIH research portfolio. A new generation of genome-sequencing instruments capable of producing vast amounts of high-quality data now makes it possible for investigators outside of large sequencing centers to generate enormous amounts of sequence data in their own laboratories. Often, however, these researchers then face a serious challenge due to the lack of access to readily usable versions of software tools needed to analyze such large amounts of data, nor the informatics expertise necessary to take best advantage of them. There is thus an acute need for robust, well-documented, and well-supported software tools for processing and analyzing the genomic data that individual laboratories can now generate. The demand for such computational tools will only grow with the increasing uptake of large-scale genome sequencing and the development of new applications for genome-sequencing data, including clinical studies.
Data generated by projects such as ENCODE and 1000 Genomes are most valuable when they can be readily accessed and used by the broader biomedical research community. Therefore, NHGRI funds the development, refinement, and maintenance of readily accessible computational and bioinformatics resources, including collections of genomic data, new data-analysis tools, and community data standards.
Quality standards for genome-sequencing data must necessarily be higher for clinical care compared to research uses. Therefore, the routine and widespread use of genome sequencing in the practice of medicine will require the development of new computational and bioinformatics tools that are able to meet the specific regulatory standards required by the Food and Drug Administration and other oversight groups. These tools must be designed for use by healthcare professionals who likely will not have extensive training in genomics or bioinformatics. NHGRI is engaging in efforts to advance this specialized area of genomics, including the development of robust clinical genomics informatics systems.
Education and Training: Realizing the benefits of genomics will require more than the research tools and clinical practices under development across the NHGRI research portfolio. It will also require healthcare professionals that are appropriately trained to understand genomic data and how to apply them to advance medical care; it will further require a public that understands genomics in general terms and is comfortable with the use of genetic and genomic data for making their healthcare decisions. Therefore, appropriate education and training of healthcare professionals and the general public will be key to the ultimate success of genomic medicine. To support these needs, NHGRI fosters many education and training activities aimed at teaching genomics to different core audiences: the next generation of genomics and genomic medicine researchers, healthcare providers, the general public through the incorporation of genomics into primary and secondary education, and lifelong learning outreach.
Budget Policy: The FY 2013 President's Budget request for Education and Training is $25.1 million, a decrease of $0.039 million or 0.16 percent less than the FY 2012 Enacted level. NHGRI will continue in FY 2013 its support for training the next generation of genomics researchers as well as programs aimed at bringing genomics to healthcare professionals and the general public.
Genomics and Society: Since its inception, NHGRI has funded research that examines the social, ethical, and legal implications of genomic advances and the increasing availability of genomic information. This research area continues to be a vital component of the Institute's strategic vision. In July 2011, a new set of research priorities for the NHGRI Ethical, Legal, and Social Implications (ELSI) Research Program were issued that focus on the following four areas:
Together, these research programs will continue to examine issues that arise in the design and conduct of genomic research, such as questions about informed consent, data sharing, and privacy; when and how best to return individual genomic results to research participants; and whether and how to provide information about incidental genomic findings to participants. Other research supported by the Institute will examine how advances in genomic technologies are influencing healthcare delivery and, more importantly, affecting the population's health. Research that examines more fundamental questions, such as how we conceptualize and understand the health-disease continuum and individual responsibility for health and behavior, is also vital for the development of effective regulations and public policies.
The Institute's Intramural Social and Behavioral Research Branch (SBRB) conducts leading-edge research at the intersection of genomics and society SBRB scientists are focused in four highly relevant conceptual domains:
Through these collective research initiatives, NHGRI remains at the forefront of bioethics research and training, accounting for approximately one-third of all bioethics research funding at the NIH.
Budget Policy: The FY 2013 President's Budget request for Genomics and Society is $26.0 million, a decrease of $0.046 million or 0.18 percent less than the FY 2012 Enacted level. The ELSI budget is legislatively mandated at 5.0 percent of the total NHGRI extramural budget. In FY 2013, NHGRI will continue to support the ELSI research program and the Intramural Social and Behavioral Research Branch in their efforts to anticipate and address the social, legal, and ethical issues that will arise from new information about the human genome and the genetic contribution to human disease, and new approaches to applying that information to the improvement of human health.
Research Management and Support: The NHGRI's Office of the Director, part of the Research Management and Support program, oversees the operation of the Institute and includes a number of component parts. Major ongoing initiatives for which the Office of the Director provides key leadership and financial support include National DNA Day and other educational outreach activities, community genomics programs, and the development of genetics education resources for health professionals. Through these activities, the Office of the Director supports a suite of innovative communication tools to convey the NIH and NHGRI messages to the public and the media. Recent activities aimed at increasing public fluency with genomics have included a workshop on how best to improve genomic literacy among the public, the creation of a mobile application version of the NHGRI Talking Glossary of Genetic Terms, and the development of an exhibition on genomics in conjunction with the Smithsonian Natural History Museum. NHGRI also continues to provide leadership in the area of healthcare professional education, with web-based resources such as the Genetics/Genomics Competency Center (G2C2) [g-2-c-2.org], and the Global Genetics and Genomics Community (G3C) [g-3-c.com]. G2C2 is a centralized repository for health professional education resources and aims to help the development of standardized curriculums. G3C is a bilingual collection of virtual case studies that provide students with a self-guided learning experience.
Budget Policy: The FY 2013 President's Budget request for the Research Management and Support program is $25.7 million, no change from the FY 2012 Enacted level. In FY 2013, NHGRI will continue to increase efficiencies in travel and conferences in an effort to reduce costs. NHGRI also plans to continue addressing the challenges and opportunities that exist in strategically managing a research portfolio that addresses areas of critical research.
Includes FTEs which are reimbursed from the NIH Common Fund for Medical Research.
Includes FTEs which are reimbursed from the NIH Common Fund.
Last Reviewed: December 29, 2012


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A Network Engineer at Irrational Games in Boston Job Posting on LinkedIn seems to indicate some sort of multiplayer support for BioShock Infinite, saying: "Right now we're looking for an talented and experienced individual to help us with the networking aspects of BioShock Infinite. This position will require a combination of initiative, leadership, design, coding, and daily problem solving on multiple target platforms." The responsibilities section says this position will: "Work with the team who created BioShock network code," and is "Responsible for delivering a robust, scalable, and responsive client-side networking support on the PC, PS3, and Xbox 360 platforms." Thanks supererogatory.
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Dogs of the House of the Day
Pets may be the prized possessions of most homeowners, but do they help a house get sold? The WSJ Mansion team has a look at the numbers, and some of the cutest pets from previous Houses of the Day.
This transcript has been automatically generated and may not be 100% accurate.
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Traditional medium jazz track. Some solos to create interest in your videos.
Similar track: Spanish Dance
Similar happy track: Jazzy fun
If you enjoy this track, or any of my other work please rate it or offer up any comments you may have. Customer feedback is my biggest motivator!
Videohive authors you are welcome to use preview files for your projects.


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dave pierce carpentry185 Feedback reviews, 100% positive
i have plenty of experience in all aspects of the trade,kitchen fitting,laminated floors,door hanging,skirts and architraves etc,i like to think im a very clean worker and always leave a job in the same condition id like to find it.i am always available for free advice,...
Latest Flooring feedback review:
By chris_1l1f on 12th May, 2016
Ben Weiss trading as Prime Fit Flooring41 Feedback reviews, 100% positive
Hi there I'm a professional laminate and wood floor fitter who first started fitting floors around 15 years ago. Currently and for the last 4 years I have been fitting floors for the largest flooring contractor in the uk (Designer Contracts) who fit for Bellway, Taylor...
Latest Flooring feedback review:
By kiwimash on 2nd Dec, 2018
Southend Flooring126 Feedback reviews, 100% positive
We are a small team of highly skilled tradesmen with a high standard of customer service Southend flooring has experience in large commercial projects and private domestic projects Carpet tiles, contract carpet, safety flooring with cap/cov, 12mm solid laminate and...
Latest Flooring feedback review:
By mel_254 on 1st May, 2018
Max Barnard217 Feedback reviews, 96% positive
I have been trading since 1986 installing all types of wood flooring and also property maintenance ,with many happy customers and most of them giving me repeat work . On the maintenance side of the company , this work is from painting ,decking and much more.Honest and very...
Latest Flooring feedback review:
By carol9858 on 15th Jan, 2019
RDH Flooring45 Feedback reviews, 100% positive
RDH Flooring is a growing business offering carpets, vinyl and hard flooring to clients throughout Essex and London. The business, which is based in Essex, began trading in 2000 and has over 25 years experience in the Flooring business.
Latest Flooring feedback review:
By megumi0328 on 17th Nov, 2018
A. Bright Carpentry38 Feedback reviews, 100% positive
Hi, my names Alex I'm 29 and I have been in the construction industry since leaving school 13 years ago. More specifically I have been in carpentry and joinery for over 7 years now. I have done projects all over London and Essex from general domestic carpentry to high spec...
Latest Flooring feedback review:
By elaine22930 on 10th Oct, 2018
Macs Flooring Ltd43 Feedback reviews, 100% positive
Trading for over 20 years, I previously completed work for IKEA and a local shop Suttons for 13 years, before starting Mac's Flooring. In addition to completing both domestic and commercial work,I also sub-contracted for Dyfed Richards for 3 years in London, from working in...
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By rosemary64956 on 6th Jan, 2019
SGR Services139 Feedback reviews, 100% positive
Experienced carpenter at reasonable rates. 25 years experience Fully qualified
Latest Flooring feedback review:
By clair35664 on 22nd Nov, 2018
Lee De Ath Flooring Solutions43 Feedback reviews, 98% positive
Specialising in all aspects of flooring I can provide free professional advice, samples & quotes. I am dedicated to completing each job to the highest standard leaving customers happy. I am confident in the ability of my team & proud of our work. No job is complete until...
Latest Flooring feedback review:
By emstanton on 26th Mar, 2018
SIMHANDYMAN LTD154 Feedback reviews, 98% positive
Dear Customers, I am updating my profile every day. For all the invitations - I am available after 2/Nov/2018, Please invite me if your job can start after this date. Cheers!
Latest Flooring feedback review:
By jacky31045 on 22nd Aug, 2018
J&k Flooring49 Feedback reviews, 96% positive
Hello my name is John Stubbins, i have been supplying and laying floors for over 40 years i also fit customers flooring i can fit all types of flooring i.e. carpets vynils all wooden floors also all prepartion of floors
Latest Flooring feedback review:
By hayley_green on 4th Jul, 2018
THE SANDING COMPANY LTD12 Feedback reviews, 100% positive
The Sanding Company Ltd undertakes all service aspects of wood flooring. With the most up to date dust free sanding machines, fully qualified staff the company delivers a professional wood floor/kitchen worktop sanding, renovation and fitting service to residential &...
Latest Flooring feedback review:
By chris_1s4t on 21st Nov, 2017
Carpets Direct31 Feedback reviews, 100% positive
My name is Graham Thurston, owner of Carpets Direct, the largest independent flooring company in the South East with top quality floor fitters. I personally have over fifty years' experience in the trade, hence I have the contacts and knowledge to guarantee any...
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By rowden_50 on 14th Oct, 2018
burrows flooring13 Feedback reviews, 92% positive
Hi, there We do a wide range of flooring from carpets,laminate,lvt to commercial flooring. We pride our selves on giving the customers what they want and leave them feeling happy with the service they received. We will always do our best to give you a competitive...
Latest Flooring feedback review:
By nousk on 30th Sep, 2016
PRO-TILE171 Feedback reviews, 98% positive
Hi please feel free to contact me for a free no obligation quote.thanks steve.
Latest Flooring feedback review:
By gary_642 on 12th Nov, 2014
Need a tradesman?
Post a job on MyBuilder to find a quality, local tradesperson.
How MyBuilder works
1. Post a job
First, create a job listing for your flooring project. It's quick, easy and free - the first step to finding recommended flooring fitters in CM0, Southminster.
2. Hire a tradesman
Having met our recommended flooring fitters in CM0, Southminster and read customer reviews, you're ready to decide which flooring fitters to hire.
3. Leave feedback
After your project is successfully completed, you can leave a review for your flooring fitters. This review helps you and future MyBuilder users.
What our customers say
- "This website helps people struggling to find builders - it has been so easy to use and clever in its conception."
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Tradesmen in CM0, Southminster
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adidas adiZero Primeknit Marathon Pack
standard bank personal loan continues to push its adiZero Primeknit sneaker, the latest one in their running collection. On December 24th, the German sport giant will be releasing the Primeknit Marathon Pack, celebrating 4 of the biggest marathon running events of the year – New York, Berlin, Beijing and Honolulu.
"This time round the colour palette is a little more adventurous, green representing Honolulu, Black & white for New York, Berlin, electric white and Beijing Blue & white. All feature the adidas performance logo on the heel of the shoe with the adizero logo sitting on the lateral side of the fade midsole.
The adizero Primeknit is manufactured using revolutionary digital knitting technology producing a seamless one-piece upper, delivering a lightweight runner combined with comfort and less waste – traditional sports shoes are constructed from several different pieces, but this breakthrough method digitally knits the entire upper in just one. It performs and supports where it counts and is needed in every part of the shoe, as knitted fused yarn fine-tunes all this. Although having a complex looking, yet minimalistic build of no lining or reinforcements, the fused yarn provides sturdy build and ventilation from the digitally-knitted distinct grid patterns, which wraps seamlessly around your foot."
http://uristocrat.com/cost-cialis-without-prescription/ drops them tomorrow, each priced at 145 Pounds. Detailed images follow in the above gallery.
tax relief claim is a post by small loans in 15 minutes on Highsnobiety.


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25th September to 25th December
90 Days of Xmas.....that is my take for this festive season.
So to begin I have decided to post photos of all items that I make during this period in a weekly post preferably on Fridays. As I have been 5 days late in coming up with this new post series I have pics of cards I made last year before I decided to start this journey of turning my hobby into a handmade small business.
And while I was searching through the myriad of pictures from way back when I came across some of my earliest creations, and it was so funny in a weird sort of way to see how I have progressed from those cards to the ones I create now.
They were made for Christmas 2010 and I mainly used items I had such as gift tags, ribbons and bits of scrap paper I had lying around. Here are the pictures....
The following pics were I think from an even earlier time.....
Now back to our previous discussion, that of posting weekly photos of Seasonal Christmas Cards till December 25th. I was also thinking of giving away free printable of gift tags and other xmas related items.
The first posting of pics can be found on my Facebook Page but the rest will be featured as a posting here on the blog and the pics added to an album on the FB page.
Here are the pics that has been posted for the first week, what a difference just in the style of photography. I suppose reading all these articles on how taking good pictures are vital is finally starting to sink in. I do believe there is much to improve on but I reckon I am getting the hang of it now...anyway back to the pics...
This collection was inspired by a white Christmas and the gold and silver colour scheme which is more popular for New Year's Eve.
I hope you enjoy them as much as it was a pleasure for me to make them.
Cheers, till next week!


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Project: White is an Unreal Tournament 3 Mod that focuses on team play. It is set in a star system on the verge of destruction, as its sun is caught up in the throes of a chain of supernovae. The colonies of this system have months till exodus, but which colonies will be included? It is an Unreal Tournament 3 Modification with the express purpose of trying to successfully build out the White universe. The focus of this project is to bring a couple new game types to the Unreal Franchise and at the same time network the team with the rest of the unreal community. Our project's heart is in multiplayer interaction over the internet or LAN, but we are going to include some extensions of the AI to allow it to make playing alone more interesting.
Only registered members can share their thoughts. So come on! Join the community today (totally free - or sign in with your social account on the right) and join in the conversation.


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Reviewed By Fred B (Fort Myers, FL) Reviewed for a 2017 Porsche 718 Cayman —2/16/2017 3:19 PM
This cover has so many positives. I bought to allow my Bulldog to ride in my new Porsche and it does everything well, even allowing hair to be shaken off. Only negative is its stiffness which keep wrinkles and it should have a band to keep front in place, hence 4 stars.


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This is a game about light curves that will test your ability to figure out things about an asteroid from just a graph of its brightness. Astronomers use telescopes to collect light curves - measurements of the brightness of distant asteroids over... (View More) time. It is part of the Killer Asteroids Web Site. The site also features a background overview of the differences between asteroids and comets, information on different types of asteroids (rubble piles vs monoliths), a discussion of how at risk Earth really is to an asteroid or comet impact, and background information on light curves. (View Less)
Materials Cost: Free
Learners will study the essential components and variables of an ion propulsion system. Activities include an on-line ion propulsion engine simulation and design. Included are changes in energy and fuel consumption as a result of variable changes... (View More) (dependent/independent variable relationships). This is activity 5 of 5 in Structure and Properties of Matter: Ion Propulsion. (View Less)
Materials Cost: Free


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Adjustable ladies fit.
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In honor of the Tour de France victory of Cadel Evans, we're making it a little easier to ride like Cadel, or at least wear his Diadora shoes! Our Diadora shoes are on sale right now, including the Proracer 3 road shoes worn to victory in the 2011 Tour de France. We've had a chance to check out the Proracer 3 here in the office, and it's definitely got Italian style to go along with it's pro-level features (which include an extra-thin, yet highly rigid carbon sole, durable D-Skin microfiber upper, and Multifit Adjust closure system with Micro CL buckle and Quick Adjustment strap, to find your perfect fit).
One of the most respected brands in cycling, Diadora has been worn to victory in the Giro d'Italia, the Vuelta, the Olympics, the World Hour Record, and, of course most recently, in the 2011 Tour de France. Diadora makes a full array of road and mountain cycling shoes that employ innovative technology to offer unmatched, pro-level power transfer, superior ventilation and the ultimate in ergonomic comfort.
But since we're talking about Cadel, we thought we'd share the best pictures of Cadel that we took during our Performance Tour du Jour trip to France. Above, Cadel is powering the chase group up the Col du Galibier on Stage 18, to narrow the gap on Andy Schleck.
Cadel sprinting to the finish on top of the famous climb of Alpe d'Huez in Stage 19, with Andy Schleck in the background.
Here's Cadel in a moment of calm after Stage 19, bundling up for the ride to the team bus.
Cadel rocketing off at the start of his time trial in Grenoble, in Stage 20.
And powering home to take the yellow jersey from Andy Schleck with a dominating performance, easily making up his 57 second time deficit from the start of the day.
Here's Cadel in the peloton during the final stage in Paris, riding down the Rue de Rivoli in his new yellow jersey.
So if you're ready to ride like Cadel, check out our Diadora shoes on sale today!


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• • Server Chip Faces Radical Evolution Over Next Decade
Jason Mick, Internet Evolution Individualism | [T]he server and workstation markets still follow a dinosaur of a chip design paradigm. Each OEM goes out and does the entire design process itself, producing monolithic chips. The approach is sort of the digital equivalent of Ayn Rand's objectivism -- in the sense that it is radically individualist. But this age of radical individualism in the PC market is coming to a close.


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Thomas Construction of Osage Beach has been dealing with extended bouts of rain as it continues to make progress on the lake's newest moving theater ― Eagles' Landing 8 Cine.
Thomas Construction of Osage Beach has been dealing with extended bouts of rain as it continues to make progress on the lake's newest moving theater ― Eagles' Landing 8 Cine.
Wehrenberg Theatres announced plans last year to build a state-of-the-art, 23,283 square-foot, eight-screen facility at Eagles' Landing. Construction started during the winter, and completion is anticipated later this year. The theater will seat 1,128 moviegoers in eight all-digital auditoriums.
According to Eagles' Landing project manager Andy Prewitt, the new theater will help make the new retail center a lake destination.
With the opening of Route 242, motorists are able to travel easily from the west side of the lake across the Community Bridge and directly to Eagles' Landing. The development's Lake Ozark location is easily accessible from any area of the lake. Eagles' Landing is located on Highway 54 in Lake Ozark.
In 1904, Fred Wehrenberg, a one-time blacksmith who operated a saloon/grocery/butcher shop, explored the St. Louis World's Fair and saw a simple film clip of passengers riding a train while scenery rushed by in the background. The film inspired Wehrenberg to rent a former bakery and launch the Cherokee Theatre in 1906. As customers watched silent films, Fred's nephew drummed in the background while his wife, Gertrude, played piano in the pit. The Wehrenbergs survived the Great Depression due in part to the stability of the movie industry and continued to prosper.
Wehrenberg Theatres has remained family-owned and operated. Ron Krueger continues today as Co-CEO, cementing Wehrenberg's standing as the oldest family-owned and operated theatre circuit in the nation.