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San Francisco State University: Speech Code Litigation Project
Category: Free Speech
Schools: San Francisco State University
SFSU put its College Republicans on trial before a campus tribunal (see more here) for stepping on makeshift Hamas and Hezbollah flags during an anti-terrorism rally. The College Republicans claimed that SFSU's speech codes were facially invalid, and with the help of the Alliance Defense Fund and the support of FIRE's Speech Code Litigation Project, sued the university. The lawsuit ultimately resulted in an injunction against SFSU, effectively striking down unconstitutional speech codes across the entire California State University system.
SFSU Outdoor Event Request Form 2008 – 2009
Letter from ADF attorney David Hacker to SFSU
Court Order for San Francisco State University, November 19, 2007
SFSU's Speech Codes Named in Complaint
Students who 'desecrated' terrorist flags vindicated
November 9, 2007
In a decision hailed as a victory for free speech, a federal judge ordered San Francisco State University and the California State University system to stop enforcing speech codes used to prosecute students for the "desecration" of flags used by terrorist groups. U.S. Magistrate Judge Wayne Brazil issued a preliminary injunction to bar the schools from enforcing several policies challenged in a lawsuit. One required students to act in accordance with SFSU "goals, principles, and policies" and another, a CSU system-wide policy, called for students "to be civil to one another." "This decision is a vital step in the fight […]» Read More
Speech Code of the Month: Arkansas State University
August 4, 2014
FIRE announces its Speech Code of the Month for August 2014: Arkansas State University.» Read More
The Pitt Promise: A Commitment to Civility over Constitutionality
July 23, 2014
One needs only to flip five pages into the University of Pittsburgh's Student Code of Conduct and Judicial Procedures to find "The Pitt Promise: A Commitment to Civility" (the "Pitt Promise," or "the Promise")—a list of pedagogical principles and values to which students are expected to adhere. In principle, the pledge is morally sound and perhaps desirable, but, as FIRE has explained, mandating civility clauses infringes on students' First Amendment rights. As a current student at the University of Pittsburgh, a public institution of higher education that is bound by the Constitution, it concerns me that the university has enacted a policy that so clearly infringes on its students' rights.» Read More
ADF's David Hacker on Civility Codes as Speech Codes
August 12, 2010
Last week in The Christian Post, Alliance Defense Fund (ADF) Legal Counsel David J. Hacker took aim at an August 5, 2010, article titled "Rude Democracy" in Inside Higher Ed, written by Susan Herbst. Herbst discusses the perceived lack of civility in contemporary American discourse, both in the larger society and on university campuses, and argues that one solution to the problem as presented on campus is to maintain and enforce civility policies regulating student expression. Herbst writes that civility policies should play a major role in how universities counsel their students to behave on campus and should be used more prominently […]» Read More
SFSU Policy Change Just Another in a Long Line of Free Speech Zone Reversals
April 7, 2010
Sam reported last week that San Francisco State University (SFSU) has revised its "Use of Buildings and Grounds" policy, which previously limited campus demonstrations and other expressive activities, such as distributing literature, to specified free speech zones. SFSU's revised policy allows students to distribute literature anywhere in the university's outdoor spaces so long as pedestrian traffic is unimpeded. As for rallies and demonstrations, the revised policy does not specify any free speech zones, and allows for spontaneous events "occasioned by news or issues coming into public knowledge" as an exception to its requirement for advanced reservation for outdoor student events. […]» Read More
SFSU Eliminates Free Speech Zones
April 2, 2010
There is good news for students at San Francisco State University: pursuant to the university's revised policy on the Use of Buildings and Grounds, demonstrations and other expressive activities are no longer restricted to free speech zones. Under the old policy, "rallies and demonstrations" at SFSU—a university of more than 30,000 students—were restricted to "Public Forum Areas (i.e., Student Union Plaza Area)." Similarly, the distribution of literature was restricted to "the Student Union Plaza behind the blue lines marked on the pavement." The revised policy contains no such restrictions. Now, "[d]istribution of literature may occur in University outdoor areas as […]» Read More
Universities' Compliance with Speech Code Decisions Leaves Much to Be Desired
September 24, 2009
FIRE's newest Justice Robert H. Jackson Legal Fellow is Erica Goldberg. Erica is a graduate of Tufts University, where she was editor-in-chief of Tufts' weekly newspaper, and of Stanford Law School, where she was a member of the moot court board. She also served as a law clerk to the Honorable Ronald L. Gilman on the Court of Appeals for the Sixth Circuit, where she was confronted with various deprivations of freedom of expression. Before becoming a Robert H. Jackson fellow, Erica worked for two years as an appellate attorney at Latham & Watkins in Washington D.C. and then as […]» Read More
Remembering September 11 and the Freedoms that Make Us Americans
September 11, 2008
On the seventh anniversary of the 9/11 terrorist attacks on our nation, FIRE joins the rest of the country in remembering those who were lost. As we look back on that day, it is important that we also remind ourselves of the importance of the freedoms that make this country what it is, and that we commit ourselves to defending those freedoms when they are threatened. As those who follow FIRE's work well know, many, if not most, American colleges and universities restrict freedom as much as they claim to promote it. In fact, in the immediate wake of the […]» Read More
Victory at San Francisco State, But Serious Concerns Remain
September 9, 2008
Yesterday, I reported about the Outdoor Event Request Form policy at San Francisco State University (SFSU) barring all student groups from holding outdoor events. The Alliance Defense Fund (ADF) wrote to SFSU on behalf of the College Republicans demanding that SFSU respect its students' First Amendment rights and change the policy. We are happy to report that J.E. Saffold, Vice President for Student Affairs and Dean of Students, promptly responded to ADF's letter and retracted the ban on outdoor events. That said, we are a little irked at Saffold's dishonesty. Saffold claims that groups were never barred from holding events […]» Read More
San Francisco State University Puts Indefinite Hold on Outdoor Protests
September 8, 2008
San Francisco State University is at it again. SFSU has posted a statement on its website suspending all outdoor protests. The statement reads: The Outdoor Reservation Request Process for Fall 2008 and Spring 2009 events has been postponed until further notice per University Administration. The postponement will be in effect until completion of a review of Time, Place, and Manner policies by a task force with final recommendations subject to Presidential approval by the President's Cabinet. It is the intent that the review will be completed in early summer. We apologize for any inconvenience. The College Republicans intend to hold […]» Read More
Victory over San Francisco State University's Unconstitutional Speech Codes
March 4, 2008
Chalk up another victory for FIRE's Speech Codes Litigation Project. Today's press release discusses the settlement of the lawsuit against San Francisco State University (SFSU), challenging the school's unconstitutional speech codes. The press release explains: SFSU's speech codes had banned expression clearly protected by the United States Constitution. For example, the college's sexual harassment policy defined sexual harassment as "one person's distortion of a university relationship by unwelcome conduct which emphasizes another person's sexuality." A policy regulating student organizations had banned any conduct "inconsistent with SF State goals, principles, and policies." In addition, the SFSU College Republicans was unconstitutionally targeted […]» Read More
Victory over Unconstitutional Speech Codes: San Francisco State University Settles Lawsuit with College Republicans in Favor of Free Speech
March 4, 2008
SAN FRANCISCO, March 4, 2008—Yesterday, San Francisco State University (SFSU) settled a lawsuit challenging its speech codes by agreeing to modify several unconstitutional policies to make them consistent with the First Amendment. The settlement also requires SFSU to pay damages to members of the university's College Republicans as well as to pay the College Republicans' attorney fees. The lawsuit—part of the Foundation for Individual Rights in Education's (FIRE's) Speech Codes Litigation Project—was filed in July 2007 by attorneys from the Alliance Defense Fund (ADF). "Unconstitutional speech codes have been dealt yet another blow," FIRE President Greg Lukianoff said. "This lawsuit […]» Read More
SFSU: Another Speech Code Falls
November 8, 2007
As we announced in our press release today, a federal judge granted a preliminary injunction prohibiting San Francisco State University (SFSU) and the California State University (CSU) System as a whole from enforcing several unconstitutional speech codes. The codes were challenged in a lawsuit filed by attorneys from the Alliance Defense Fund (ADF) in cooperation with the Foundation for Individual Rights in Education (FIRE). This lawsuit—the latest in FIRE's Speech Codes Litigation Project—was filed by the SFSU College Republicans and two of the group's individual members after SFSU violated the group's First Amendment rights last year by dragging them through […]» Read More
Federal Court Orders San Francisco State University, California State University System Not to Enforce Unconstitutional Speech Codes
November 8, 2007
SAN FRANCISCO, November 8, 2007—In a crucial victory for free speech, a federal judge has ordered San Francisco State University (SFSU) and the California State University System (CSU) to stop enforcing several unconstitutional speech codes. The codes were challenged in a lawsuit filed by attorneys from the Alliance Defense Fund (ADF) in cooperation with the Foundation for Individual Rights in Education (FIRE). "This decision is a vital step in the fight against unconstitutional campus speech codes," FIRE President Greg Lukianoff said. "The court's decision frees hundreds of thousands of students throughout the CSU System from unlawful restrictions on their expression." […]» Read More
Students Sue San Francisco State University over Unconstitutional Speech Codes
July 9, 2007
SAN FRANCISCO, July 9, 2007—San Francisco State University (SFSU) is the latest target of the Foundation for Individual Rights in Education's (FIRE's) highly successful Speech Codes Litigation Project. In cooperation with FIRE, attorneys filed a federal lawsuit against SFSU for violating the First Amendment rights of its students. The Alliance Defense Fund (ADF), a Phoenix-based nonprofit organization devoted to protecting religious liberty, filed the suit. "Through its policies and practices, SFSU has violated and continues to violate the First Amendment rights of every student on its campus," FIRE President Greg Lukianoff said. "Beginning today, SFSU will have to answer for […]» Read More


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Home » Posts tagged 'art cars'
Tag Archives: art cars
35 years of painted racing machines…
from BMW
The concept for the BMW art cars was introduced by Hervé Poulain, an auctioneer and ardent racing driver from France. Poulain was searching for a link between art and cars and he asked his friend and renowned artist Alexander Calder to paint a rolling canvas on the BMW 3.0 CSL that he would race in the 1975 Le Mans endurance race. Poulain's 3.0 CSL was the first car to create a symbiosis between the world of art and the world of motorsport. Prompted by enormous enthusiasm for this work of art on wheels, BMW then decided to put its brilliant idea of establishing the Art Car Collection into practice.
the artists: Alexander Calder 1975, Frank Stella 1976, Roy Lichtenstein 1977, Andy Warhol 1979, Ernst Fuchs 1982, R. Rauschenberg 1986, M.J. Nelson 1989, Ken Done 1989, Matazo Kayama 1990, Cesar Manrique 1990, A.R. Penck 1991, Esther Mahlangu 1991, Sandro Chia 1992, David Hockney 1995, Jenny Holzer 1999, Olafur Eliasson 2007, Robin Rhode 2009, Jeff Koons 2010

subset: commoncrawl


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After 12 "Molly" overdoses and numerous drug arrests at the outdoor club, the club manager and Marina Bay manager agreed to the city's request to pull the plug on two scheduled events. The club may not reopen next year.
After a summer of 12 "Molly" overdoses and a string of drug arrests, the Ocean Club at Marina Bay has probably seen its final show – ever.
Quincy's police chief and city clerk said the outdoor music club's manager and Marina Bay's manager will cancel a private event on Sept. 13 and an over-21 DJ show Sept. 20, as the city requested.
Meanwhile, a spokesman for Mayor Thomas Koch said "there's not likely to be an Ocean Club" by next spring, if a planned apartment and retail development at the site proceeds as expected.
Police Chief Paul Keenan and City Clerk Joe Shea said Thursday afternoon that Marina Bay manager Brian Ferrara and club manager Tim Collins readily agreed to pull the plug on the two September shows.
"They understand the scope of the problem," Keenan said.
Ferrara and Collins couldn't be reached for immediate comment about the half-hour, informal session. The Ocean Club's last previous event was an Aug. 30 show.
The club operator, Frank DePasquale of Boston, leases the site from Flagship Marinas, which owns Marina Bay.
The club can hold 1,600 patrons and draws them from the greater Boston area and surrounding states. The Sept. 13 party and Sept. 20 Afrojack show would have been the season's last events.
The Ocean Club is the second high-profile Boston-area music venue to be investigated in the last two weeks for overdoses connected to "Molly," which is the street name for a pure, more potent version of MDMA, the psychedelic drug ecstasy.
In late August three patrons at the House of Blues in Boston overdosed – among them, New Hampshire college student Brittany Flannigan, who died.
Thursday's Quincy meeting came a day after Keenan released details of the season's non-fatal overdoses and arrests.
Quincy police got the first reports of overdoses at the club in late May. Plainclothes detectives investigated the club starting in mid-July, and since Aug. 23 have charged eight people for alleged possession or intent to distribute the ecstasy drug "Molly" or cocaine.
Only one of those charged is from the South Shore – William Naumenko, 23, of Hull – and only one of those who overdosed is from the South Shore. Most of those charged are from Rhode Island and Connecticut.
Two of the arrests were made Aug. 30, the night of what turned out to be the club's last show of the season. Four more were made Sept. 1.
Keenan said there's no indication that anyone at the club was involved with alleged "Molly" dealing or possession.
Shea said DePasquale and Collins want to re-open in April 2014 as usual, if a development proposed for the club site is delayed. If that happens, Keenan said police and the club will prepare a safety and security plan "acceptable to all parties" – and that will meet all police concerns.
But like Mayor Koch, Keenan said "that may be a moot point" if Flagship Marinas begins construction of the 400-unit apartment complex and retail shops by April.
That would spell the end of the Ocean Club. Shea said Ferrara told him that Flagship has no plans to relocate the club elsewhere at Marina Bay.
Lane Lambert may be reached at firstname.lastname@example.com or follow on Twitter @LLambert_Ledger.
READ MORE about the ecstasy drug "Molly."


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Daily Freeman Life Editor Ivan Lajara talks about journalism, living in the Hudson Valley, language, the Web, cats and even politics. But he shouldn't.
Monday, July 28, 2008
Cute, as a button
Saturday, July 26, 2008
Multimedia extravaganza
In case you missed it, many stories we published have accompaniying online features, something we've been doing for a while now.
Below are the videos and songs linked with our features.
Friday, July 25, 2008
Bart Thrall's "The Collector"
Delmark Goldfarb's "Up to My Neck"
1. "Shoot the Angels Down"
2. "I Need Your Love"
3. "Portable Man"
4. "Got Something Good With Her"
5. "Hungry For My Baby's Love"
6. "Don't Bring Me No Flowers"
7. "Somebody's Got the Blues"
8. "If You Lose Your Money"
9. "Mr. Jailer Man"
Wednesday, July 23, 2008
Fast food follies
To add some value to the column, unlike my worthless "value meal," here are some useful links:
* "Exiling the Happy Meal," by the Wall Street Journal
Here's the video (messing up the layout of this page) that goes with that story
Here are some links to "Nutrition Facts," which are facts, indeed, but I'm not so sure about the "nutrition" part.
* McDonald's numbers are listed on its web site, but for the ingredients, you have to go to this almost misleading page.
Why "almost misleading"?
Because the first listing is of hamburger ingredients, which are "100% Beef Patty, Regular Bun, Ketchup, Mustard, Pickle Slices, Onions." But scroll down and the bun's ingredients are listed:
"Enriched flour (bleached wheat flour, malted barley flour, niacin, reduced iron, thiamin mononitrate, riboflavin, folic acid), water, high fructose corn syrup, yeast, soybean oil, canola oil, partially hydrogenated soybean oil, contains 2% or less of each of the following: sesame seed, salt, wheat gluten, calcium sulfate, ammonium sulfate, monocalcium phosphate, ammonium chloride, calcium carbonate, baking soda, soy flour, dough conditioners (may contain one or more of the following: distilled monoglycerides, DATEM, ascorbic acid, azodicarbonamide, enzymes, ethoxylated mono- and diglycerides, sodium stearoyl lactylate, guar gum, mono-and diglycerides, calcium peroxide), calcium propionate & sodium propionate (preservatives), soy lecithin. CONTAINS: WHEAT AND SOY."
Ingredients for the Big Mac Sauce are equally disturbing.
* Burger King has a "Big Book of Nutritious Facts" which list more ingredients a single brain can handle, much less a stomach.
* Wendy's ("it's waaaay better than fast food") is fast food, nonetheless. And just as nasty. Here is a link to Wendy's "nutrition facts."
Here and there:
* Notice how all Web sites promote "healthy" activities, hence the surfer in the online version of the column, taken from McDonald's main site.
I added the burger to add flavor.
* I wonder who actually goes online to read fast food nutrition sites, other than humor writers.
* And just what in the world constitutes "Natural Flavors"?
Cow juice?
Useless trivia: The question "Are there worms in the meat?" is asked again in page 3, just in case you had just forgotten there are no worms in the meat.
"I'm lovin' it" indeed.
Tuesday, July 22, 2008
1,000 words (and a rap sheep)
"Break-in suspects found asleep on stolen goods" -- by the Associated Press
Monday, July 21, 2008
Artie Traum
The Freeman's David Malachowski called his last album, 2007's "Thief of Time," a "modern masterpiece."
Here are some tracks from that album.
1. "Bonnie Jean"
2. "Thief of Time"
3. Midnight Blue
4. "Back In The Sugarcane"
5. "Where The Blues Began"
6. "Cuckoo Bird"
7. "Last Tree In The Bronx"
8. "Halifax"
9. That Secret Place
10. "Insult A Man"
11. Country Boy Blues
There is a page of remembrances on his Web site.
Michael Dmoch
Folk musician Michael "Moose" Dmoch of Rosendale died on Sunday at Kingston's Benedictine Hospital. He was 59.
With Rebekah Lowden, he was "Redwood Moose." They had also done classical music with the Woodstock chorus Ars Choralis. The duo had also performed with Voices for Peace. He was musical director of the Rosendale Street Festival.
The photo you see here is of the couple standing in front of their burned home in Rosendale last year. Area musicians organized a fundraiser to help them in February 2007.
A memorial concert is being planned, according to family friend and soprano Danielle Woerner.
Check the Freeman for updates.
Friday, July 18, 2008
So many festivals, so little time
Other ongoing summer festivals include Belleayre Music Festival in Highmount, Maverick Concerts in Woodstock and Bethel Woods not in Woodstock.
Our area colleges also join the fun with Bard's Summerscape in Annandale-on-Hudson, Vassar's Powerhouse Theater in Poughkeepsie and SUNY New Paltz's Pianosummer.
I'm sure I'm forgetting a whole bunch more.
Thankfully, it's all in Preview today.
Wednesday, July 16, 2008
Plea bargains 'R' Us
Crazy, I know.
... by a judge.
Tuesday, July 15, 2008
The New Yorker
By "sophisticated," of course, I mean "incomprehensible." (The New Yorker's motto? "I don't get it. Get it?")
So while everyone debates the important issues like who's more offended by the cover or who would pay $4.50 a week for a magazine, here's some useful stuff for those who can see past satire:
* Here's Ryan Lizza's article about Barack Obama, "Making it," published in the outrageous magazine nobody bothered to open.
* National Public Radio's Terry Gross talked to Lizza on "Fresh Air" Monday.
* Here's magazine's cartoonist Liza Donnelly of Milan, who told the Freeman's Bonnie Langston at the end of 2005 that her "stuff is pretty gettable."
Thursday, July 10, 2008
A global phenomenon
The article is titled "A Private Dance? Four Million Web Fans Say No."
The video has more than 5.5 million hits as of Thursday morning.
Here's why:
Visit http://www.wherethehellismatt.com/
He's definitely on to something.
YouTube does the Valley
Here's my favorite, via "mailgoddess", whom I'm tracking down as you are reading this.
Kingston in the 1960s:
UPDATE: The video belongs to Tom Rigney of Kingston. It was shot by his father. Rigney said he was "dabbling on YouTube" and that the quality of the original video is much better. He also has other Hudson Valley 8mm videos from 1965 to 1974 that he's transferred into a DVD and might upload to YouTube.
We'll keep you posted.
Wednesday, July 9, 2008
Hummer factoids
There are 17 other listed limousine companies around, according to SuperPages, a Web site that's not super and it doesn't have any real pages, but maps.
* The Hummer comes in black and metallic grey and other colors that are supposed to appease your inferiority complex, but it doesn't come in green, which would have made the column a lot better. You can "make" your own Hummer on its Web site.
* Talking about The Hummer's Web site, I must say it is really well done, especially if you have a sense of irony. Mostly every photo of the beast is in a place that suffers from the truck's emissions.
* "I like to waste gas and run over children" is an actual sticker.
And a T-shirt.
A Hummer summer
The following beauty uses gas AND electricity.
The purpose is to kill mosquitoes.
This 48-pound killing machine is listed at $279 from Mosquito Central.
And get this: It has to be turned on -- all day and night -- and will run out of gas after 21 days.
Take that, Al Gore!
Wednesday, July 2, 2008
Hospital visits
His sense of humor throughout his ordeal has been inspirational, though he's still not fond of the hospital's phone bill payment "Nazi," who apparently demands cash when patients are on some heavy medication or vulnerably showcasing body parts that are usually not for public exhibition.
And, if you must know, when I'm a visitor, I'm the "How are you feeling?" kind. And I knock on the door.
Terrorism and Other Public Health Emergencies
The entire thing is available online. If you are crazy enough to read it, you might run into the image used in the column.
The reassuring guide has sections like "What we don't know" and features some tips like this:
"No reliable test exists."
"No antidote exists."
"There is no vaccine at this time."
"When a nuclear weapon explodes, a large fireball is created."
The first and only time I received a copy was 2005.
So I'm guessing the terrorists lost.


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Start Co., the Memphis-based venture development group focused on grooming startup companies and their founders, is itself about to do some starting anew.
Start Co. is now a member of the Global Accelerator Network, which includes dozens of top startup accelerators from around the world and was created as part of the White House Startup America Initiative. Start Co.'s membership will benefit entrepreneurs who participate in the venture's three local accelerators: Upstart, which is focused on women-led startups; Seed Hatchery, focused on information technology startups; and Sparkgap, a new soon-to-launch logistics-focused accelerator.
Global Accelerator Network executive director Patrick Riley said his group has been impressed with Start Co.'s programs and management over the past year, and that Start Co.'s programs "embody the values, ethos and high quality" of the global network. The group spans six continents, 63 cities and more than 50 accelerators.
"There is no doubt this is just the beginning of what will be a thriving startup community in Memphis," Riley said.
–Eric Mathews Start Co. founder and CEO
Start Co. founder and CEO Eric Mathews said benefits that Start Co. and its programs get by being part of the global network include enhancing Start Co.'s current practices and building off of the vision and expertise of the Global Accelerator Network to help local entrepreneurs become the business leaders of tomorrow.
"There are definite benefits for us," Mathews said. "There's (more than 50) accelerators they've accepted into their membership pools to kind of set a standard for excellence, as far as accelerators go. Originally stepping into this, there were a couple of areas we thought were powerful. We wanted to be able to enhance the recruitment and marketing efforts for our programs, and this helps us get that reach.
"Moving beyond that, we get benefits as far as technical assistance. There are things like meetups for managers of accelerators, and these are some of the top accelerators in the world. There's also access to their mentor and investor network. And that's important for a city like Memphis. When we have something like maybe a consumer electronics high-growth potential startup that's maybe not a perfect fit, we still want to be able to enable our entrepreneurs to move ahead and get the support they need."
Speaking of those local programs, the three local accelerators work this way: They each provide $15,000 to startup founders along with mentorship and other benefits to help them turn their ideas into viable businesses. Sparkgap is the newest of the three and launching next year, and it will focus on logistics innovations and work with logistics partners locally.
A benefit of Sparkgap is that the 115-day program will provide logistics tech founders not only with early-stage funding and mentorship from local industry figures, but they'll get to test their ideas in, according to Start Co., "the real-life laboratory of America's logistics capital."
The typical schedule for Start Co.'s accelerators is several months of intense hands-on mentoring and shepherding of the ventures culminating in Demo Days, at which the startup founders make pitches to investors for follow-on funding and hopefully sow the seeds of future growth. The most recent Demo Day was Upstart's in October.
Next year, Start Co. will do something a little different schedule-wise and run each of the three accelerators simultaneously. They'll all start May 1, with Demo Days for each program happening on a target date of Aug. 21.
The application period for each of the three accelerators is now open, and entrepreneurs who want to be part of any of the 2014 cohorts can find more details at www.neverstop.co/gan, where they also can apply.
Copyright 1995 -
by The Daily News Publishing Co. Inc. - All Rights Reserved


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Vorinostat, Temozolomide, or Bevacizumab in Combination With Radiation Therapy Followed by Bevacizumab and Temozolomide in Young Patients With Newly Diagnosed High-Grade Glioma
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT01236560
Recruitment Status : Completed
First Posted : November 8, 2010
Last Update Posted : October 12, 2017
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
|Condition or disease
|Brain Stem Glioma Cerebral Astrocytoma Childhood Cerebellar Anaplastic Astrocytoma Childhood Cerebral Anaplastic Astrocytoma Childhood Spinal Cord Neoplasm Untreated Childhood Brain Stem Glioma Untreated Childhood Cerebral Astrocytoma
|Biological: Bevacizumab Drug: Temozolomide Drug: Vorinostat
|Phase 2 Phase 3
Hide Detailed Description
I. To identify the dose of vorinostat that is feasible when given in combination with radiotherapy (RT) in patients with newly diagnosed high-grade gliomas (HGG). II. To compare 1-year event-free survival of patients with newly diagnosed HGG treated with vorinostat (using MTD) versus bevacizumab versus temozolomide when given in combination with RT followed by maintenance therapy with bevacizumab and temozolomide. (Phase II) III. To compare the event-free survival of patients with newly diagnosed HGG treated with the superior chemoradiotherapy (from phase II portion) versus temozolomide given in combination with RT followed by maintenance chemotherapy with bevacizumab and temozolomide. (Phase III)
I. To evaluate the anti-tumor activity, as measured by event-free survival (EFS), progression-free survival (PFS), and overall survival (OS), of patients with newly diagnosed HGG treated with vorinostat, bevacizumab, or temozolomide when given in combination with RT followed by maintenance chemotherapy with bevacizumab and temozolomide. II. To define and evaluate the toxicities of each of the treatment arms of the study.
III. To conduct gene expression profiling and SNP arrays in patients with newly diagnosed HGG.
IV. To assess telomerase activity, hTert expression, and telomere length in patients with newly diagnosed HGG. V. To document changes in perfusion and diffusion using MR imaging at baseline, prior to, during (prior to course 3), and after maintenance therapy with bevacizumab and temozolomide.
VI. To correlate functional changes in tumor with responses to bevacizumab treatment using MR diffusion/perfusion imaging. VII. To correlate the results of the bevacizumab biology studies in serum or tumor with EFS.
VIII. To explore the prognostic significance of MGMT status for patients newly diagnosed with HGG treated with combined surgery, radiation, chemotherapy, and anti-angiogenic therapy.
OUTLINE: This is a multicenter, feasibility, dose-escalation study of vorinostat, followed by a phase II study, followed by a phase III study.
FEASIBILITY STUDY: Patients undergo 3-D conformal radiotherapy (RT) or intensity-modulated RT 5 days a week for 6 weeks. Patients also receive vorinostat orally (PO) once daily on days 1-5. Courses repeat every week for 6 weeks in the absence of disease progression or unacceptable toxicity.
MAINTENANCE THERAPY: Beginning 4 weeks after completion of chemoradiotherapy, patients receive bevacizumab IV over 30-90 minutes on days 1 and 15 and temozolomide PO on days 1-5. Treatment repeats every 28 days for 12 courses in the absence of disease progression or unacceptable toxicity.
PHASE II STUDY: Patients are stratified according to extent of resection (near total resection or gross total resection vs other) and histology (glioblastoma multiforme vs other). Patients are randomized to 1 of 3 treatment arms.
ARM I: Patients undergo RT 5 days a week for 6 weeks and receive vorinostat at the maximum-tolerated dose determined in the feasibility study.
ARM II: Patients undergo RT as in arm I and receive temozolomide PO once daily for 42 days beginning on day 5 of RT.
ARM III: Patients undergo RT as in arm I and receive bevacizumab IV over 30-90 minutes on days 22 and 36. Patients in all arms receive maintenance therapy as in the feasibility study.
PHASE III study: Patients are randomized to 1 of 2 treatment arms.
ARM IV: Patients receive RT and temozolomide as in phase II, arm II.
ARM V: Patients receive treatment as in phase II, arm I or phase II, arm III, whichever was established as the superior chemoradiotherapy arm in phase II. Patients in all arms receive maintenance therapy as in the feasibility study. Some patients undergo blood and tumor tissue sample (from surgery) collection for telomerase activity, hTert expression, telomere length, and gene expression profiling and SNP arrays analysis.
After completion of study therapy, patients are followed up every 3 months for 1 year, every 6 months for 4 years, and then annually for 5 years.
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|101 participants
|Intervention Model:
|Parallel Assignment
|None (Open Label)
|Primary Purpose:
|Official Title:
|A Randomized Phase II/III Study of Vorinostat and Local Irradiation OR Temozolomide and Local Irradiation OR Bevacizumab and Local Irradiation Followed by Maintenance Bevacizumab and Temozolomide in Children With Newly Diagnosed High-Grade Gliomas
|Actual Study Start Date :
|November 15, 2010
|Actual Primary Completion Date :
|September 27, 2016
|Actual Study Completion Date :
|September 27, 2016
Experimental: Arm I (vorinostat)
Patients undergo RT 5 days a week for 6 weeks and receive vorinostat at the maximum-tolerated dose determined in the feasibility study.
Drug: Vorinostat
Given PO
Other Names:
Experimental: Arm II (vorinostat and temozolomide)
Patients undergo RT as in arm I and receive temozolomide PO once daily for 42 days beginning on day 5 of RT.
Drug: Temozolomide
Given PO
Other Names:
Drug: Vorinostat
Given PO
Other Names:
Experimental: Arm III (vorinostat and bevacizumab)
Patients undergo RT as in arm I and receive bevacizumab IV over 30-90 minutes on days 22 and 36.
Biological: Bevacizumab
Given IV
Other Names:
Drug: Vorinostat
Given PO
Other Names:
Experimental: Arm IV (vorinostat and temozolomide)
Patients receive RT and temozolomide as in phase II, arm II.
Drug: Temozolomide
Given PO
Other Names:
Drug: Vorinostat
Given PO
Other Names:
Experimental: Arm V (vorinostat, bevacizumab, temozolomide)
Patients receive treatment as in phase II, arm I or phase II, arm III, whichever was established as the superior chemoradiotherapy arm in phase II.
Biological: Bevacizumab
Given IV
Other Names:
Drug: Temozolomide
Given PO
Other Names:
Drug: Vorinostat
Given PO
Other Names:
- Event-free survival of patients in each treatment arm, defined as time to first occurrence of disease progression, relapse, second malignant neoplasm, or death from any cause [ Time Frame: Up to 1 year ]
- Maximum tolerated dose (MTD) of vorinostat when given concurrently with radiation therapy determined according to dose-limiting toxicities (DLTs) graded using Common Terminology Criteria for Adverse Events version 4.0 (CTCAE v4.0) (feasability study) [ Time Frame: 10 weeks ]
- Overall survival of patients in each treatment arm [ Time Frame: Up to 10 years ]
- Progression-free survival of patients in each treatment arm [ Time Frame: Up to 10 years ]
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|3 Years to 21 Years (Child, Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
Newly diagnosed high-grade glioma
- Anaplastic astrocytoma
- Glioblastomamultiforme
- Gliosarcoma
- Primary spinal cord malignant glioma allowed
- No oligodendroglioma oroligoastrocytoma
Patient must have histological verification of diagnosis
- No M+ disease (defined as evidence of neuraxis dissemination)
- No positive CSF cytology
ECOG performance status (PS) 0-2
- Karnofsky PS 50-100% (patients > 16 years of age)
- Lansky PS 50-100% (patients ≤ 16 years of age)
- ANC ≥ 1,000/μL
- Platelet count ≥ 100,000/μL
- Hemoglobin ≥ 8.0 mg/dL (transfusion independent)
Creatinine clearance or radioisotope GFR ≥ 70 mL/min OR serum creatinine based on age and/or gender as follows:
- 0.4 mg/dL (1 month to < 6 months of age)
- 0.5 mg/dL (6 months to < 1 year of age)
- 0.6 mg/dL (1 to < 2 years of age)
- 0.8 mg/dL (2 to < 6 years of age)
- 1.0 mg/dL (6 to < 10 years of age)
- 1.2 mg/dL (10 to < 13 years of age)
- 1.5 mg/dL (male) or 1.4 mg/dL (female) (13 to < 16 years of age)
- 1.7 mg/dL (male) or 1.4 mg/dL (female) (≥ 16 years of age)
Proteinuria < 2+ OR urine; protein ratio (UPC) ≤ 0.5
- If UPC > 0.5, a 24-hour urine protein should be obtained and level should be < 1,000 mg of protein
- Total bilirubin ≤ 1.5 times upper limit of normal (ULN)
- ALT < 2.5 times ULN
- Serum albumin ≥ 2 g/dL
- PT INR ≤ 1.5 times ULN
- Not pregnant or nursing
- Negative pregnancy test
- Fertile patients must use effective contraception during all study therapy and for ≥ 6 months after completion of bevacizumab
Hypertension well controlled (≤ 95^th percentile for age and height if patient is ≤ 17years) by stable doses of medication allowed
- For patients > 17 years, systolic blood pressure (BP) ≤ 150 mm Hg or diastolic BP ≤ 100 mm Hg)
- Seizure disorder allowed provided patient is well-controlled and on nonenzyme-inducing anticonvulsants
- No history of myocardial infarction, severe or unstable angina, clinically significant peripheral vascular disease, ≥ grade 2 heart failure, or serious and inadequately controlled cardiac arrhythmia
- No known bleeding diathesis or coagulopathy
- No prior arterial thromboembolic events, including transient ischemic attacks orcerebrovascular accidents
- No prior diagnosis of a deep venous thrombosis, including pulmonary embolism, and no known thrombophilic condition (e.g., protein S, protein C, antithrombin III deficiency, Factor V Leiden or Factor II G202`0A mutation, homocysteinemia, or antiphospholipid antibody syndrome)
- No history of an abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess within the past 6 months
- No serious or non-healing wound, ulcer, or bone fracture
- No evidence of significant postoperative intracranial hemorrhage, defined as > 1 cm of blood on postoperative MRI scan (potentially in addition to the postoperative scan) obtained within the past 14days
- No history of allergic reaction to Chinese hamster ovary cell products or other recombinanthuman antibodies
- No more than 31 days since definitive surgery
- Must not have received any prior chemotherapy, radiotherapy, immunotherapy, or bone marrow transplant
More than 7 days since major surgical procedure and recovered
For patients scheduled to receive bevacizumab:
- More than 28 days since major procedure
- More than 14 days since intermediate procedure
- More than 7 days since minor procedure (lumbar picture or placement of PICC lines are not considered minor procedures)
- No other current anti-cancer agents
- No concurrent nonsteroidal anti-inflammatory medications known to inhibit platelet function or known to selectively inhibit cyclooxygenase activity
- No concurrent enzyme inducing anticonvulsants
- No concurrent HDAC inhibitors (e.g., valproic acid)
- No concurrent anticoagulants including systemic thrombolytic agents, heparin, low molecular weight heparins, or warfarin except as required to maintain patency of pre-existing permanent vascular catheters or for prevention of thrombosis in the post-operative period
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01236560
Hide Study Locations
|United States, Alabama
|Children's Hospital of Alabama
|Birmingham, Alabama, United States, 35233
|University of Alabama at Birmingham Cancer Center
|Birmingham, Alabama, United States, 35233
|United States, California
|Southern California Permanente Medical Group
|Downey, California, United States, 90242
|Loma Linda University Medical Center
|Loma Linda, California, United States, 92354
|Miller Children's and Women's Hospital Long Beach
|Long Beach, California, United States, 90806
|Children's Hospital Los Angeles
|Los Angeles, California, United States, 90027
|Cedars Sinai Medical Center
|Los Angeles, California, United States, 90048
|Mattel Children's Hospital UCLA
|Los Angeles, California, United States, 90095
|Children's Hospital Central California
|Madera, California, United States, 93636-8762
|Children's Hospital and Research Center at Oakland
|Oakland, California, United States, 94609-1809
|Kaiser Permanente-Oakland
|Oakland, California, United States, 94611
|Children's Hospital of Orange County
|Orange, California, United States, 92868
|Lucile Packard Children's Hospital Stanford University
|Palo Alto, California, United States, 94304
|Rady Children's Hospital - San Diego
|San Diego, California, United States, 92123
|UCSF Medical Center-Parnassus
|San Francisco, California, United States, 94143
|UCSF Medical Center-Mission Bay
|San Francisco, California, United States, 94158
|United States, Colorado
|Children's Hospital Colorado
|Aurora, Colorado, United States, 80045
|United States, Connecticut
|Connecticut Children's Medical Center
|Hartford, Connecticut, United States, 06106
|Yale University
|New Haven, Connecticut, United States, 06520
|United States, Delaware
|Alfred I duPont Hospital for Children
|Wilmington, Delaware, United States, 19803
|United States, District of Columbia
|MedStar Georgetown University Hospital
|Washington, D.C., District of Columbia, United States, 20007
|Children's National Medical Center
|Washington, D.C., District of Columbia, United States, 20010
|United States, Florida
|Golisano Children's Hospital of Southwest Florida
|Fort Myers, Florida, United States, 33908
|Nemours Children's Clinic-Jacksonville
|Jacksonville, Florida, United States, 32207
|University of Miami Miller School of Medicine-Sylvester Cancer Center
|Miami, Florida, United States, 33136
|Nicklaus Children's Hospital
|Miami, Florida, United States, 33155
|Florida Hospital Orlando
|Orlando, Florida, United States, 32803
|Arnold Palmer Hospital for Children
|Orlando, Florida, United States, 32806
|Nemours Children's Clinic - Pensacola
|Pensacola, Florida, United States, 32504
|Johns Hopkins All Children's Hospital
|Saint Petersburg, Florida, United States, 33701
|Saint Joseph's Hospital/Children's Hospital-Tampa
|Tampa, Florida, United States, 33607
|United States, Georgia
|Children's Healthcare of Atlanta - Egleston
|Atlanta, Georgia, United States, 30322
|Memorial University Medical Center
|Savannah, Georgia, United States, 31404
|United States, Hawaii
|University of Hawaii Cancer Center
|Honolulu, Hawaii, United States, 96813
|United States, Illinois
|Lurie Children's Hospital-Chicago
|Chicago, Illinois, United States, 60611
|University of Illinois
|Chicago, Illinois, United States, 60612
|University of Chicago Comprehensive Cancer Center
|Chicago, Illinois, United States, 60637
|Saint Jude Midwest Affiliate
|Peoria, Illinois, United States, 61637
|Southern Illinois University School of Medicine
|Springfield, Illinois, United States, 62702
|United States, Indiana
|Riley Hospital for Children
|Indianapolis, Indiana, United States, 46202
|Saint Vincent Hospital and Health Care Center
|Indianapolis, Indiana, United States, 46260
|United States, Iowa
|Blank Children's Hospital
|Des Moines, Iowa, United States, 50309
|United States, Kentucky
|University of Kentucky/Markey Cancer Center
|Lexington, Kentucky, United States, 40536
|Norton Children's Hospital
|Louisville, Kentucky, United States, 40202
|United States, Maryland
|Johns Hopkins University/Sidney Kimmel Cancer Center
|Baltimore, Maryland, United States, 21287
|United States, Massachusetts
|Dana-Farber Cancer Institute
|Boston, Massachusetts, United States, 02215
|United States, Michigan
|C S Mott Children's Hospital
|Ann Arbor, Michigan, United States, 48109
|Wayne State University/Karmanos Cancer Institute
|Detroit, Michigan, United States, 48201
|Michigan State University Clinical Center
|East Lansing, Michigan, United States, 48824-7016
|Helen DeVos Children's Hospital at Spectrum Health
|Grand Rapids, Michigan, United States, 49503
|Bronson Methodist Hospital
|Kalamazoo, Michigan, United States, 49007
|United States, Minnesota
|Children's Hospitals and Clinics of Minnesota - Minneapolis
|Minneapolis, Minnesota, United States, 55404
|Mayo Clinic
|Rochester, Minnesota, United States, 55905
|United States, Mississippi
|University of Mississippi Medical Center
|Jackson, Mississippi, United States, 39216
|United States, Missouri
|The Childrens Mercy Hospital
|Kansas City, Missouri, United States, 64108
|Cardinal Glennon Children's Medical Center
|Saint Louis, Missouri, United States, 63104
|Washington University School of Medicine
|Saint Louis, Missouri, United States, 63110
|Mercy Hospital Saint Louis
|Saint Louis, Missouri, United States, 63141
|United States, Nebraska
|Children's Hospital and Medical Center of Omaha
|Omaha, Nebraska, United States, 68114
|University of Nebraska Medical Center
|Omaha, Nebraska, United States, 68198
|United States, Nevada
|Nevada Cancer Research Foundation CCOP
|Las Vegas, Nevada, United States, 89106
|Children's Specialty Center of Nevada II
|Las Vegas, Nevada, United States, 89109
|United States, New Jersey
|Hackensack University Medical Center
|Hackensack, New Jersey, United States, 07601
|Morristown Medical Center
|Morristown, New Jersey, United States, 07960
|Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital
|New Brunswick, New Jersey, United States, 08903
|Saint Joseph's Regional Medical Center
|Paterson, New Jersey, United States, 07503
|Overlook Hospital
|Summit, New Jersey, United States, 07902
|United States, New Mexico
|University of New Mexico Cancer Center
|Albuquerque, New Mexico, United States, 87102
|United States, New York
|Albany Medical Center
|Albany, New York, United States, 12208
|Roswell Park Cancer Institute
|Buffalo, New York, United States, 14263
|The Steven and Alexandra Cohen Children's Medical Center of New York
|New Hyde Park, New York, United States, 11040
|Laura and Isaac Perlmutter Cancer Center at NYU Langone
|New York, New York, United States, 10016
|Columbia University/Herbert Irving Cancer Center
|New York, New York, United States, 10032
|Memorial Sloan-Kettering Cancer Center
|New York, New York, United States, 10065
|University of Rochester
|Rochester, New York, United States, 14642
|State University of New York Upstate Medical University
|Syracuse, New York, United States, 13210
|Montefiore Medical Center - Moses Campus
|The Bronx, New York, United States, 10467-2490
|United States, North Carolina
|UNC Lineberger Comprehensive Cancer Center
|Chapel Hill, North Carolina, United States, 27599
|Carolinas Medical Center/Levine Cancer Institute
|Charlotte, North Carolina, United States, 28203
|Wake Forest University Health Sciences
|Winston-Salem, North Carolina, United States, 27157
|United States, North Dakota
|Sanford Broadway Medical Center
|Fargo, North Dakota, United States, 58122
|United States, Ohio
|Children's Hospital Medical Center of Akron
|Akron, Ohio, United States, 44308
|Cincinnati Children's Hospital Medical Center
|Cincinnati, Ohio, United States, 45229
|Rainbow Babies and Childrens Hospital
|Cleveland, Ohio, United States, 44106
|Cleveland Clinic Foundation
|Cleveland, Ohio, United States, 44195
|Nationwide Children's Hospital
|Columbus, Ohio, United States, 43205
|Dayton Children's Hospital
|Dayton, Ohio, United States, 45404
|The Toledo Hospital/Toledo Children's Hospital
|Toledo, Ohio, United States, 43606
|United States, Oklahoma
|University of Oklahoma Health Sciences Center
|Oklahoma City, Oklahoma, United States, 73104
|United States, Oregon
|Oregon Health and Science University
|Portland, Oregon, United States, 97239
|United States, Pennsylvania
|Lehigh Valley Hospital - Muhlenberg
|Bethlehem, Pennsylvania, United States, 18017
|Penn State Children's Hospital
|Hershey, Pennsylvania, United States, 17033
|Children's Hospital of Philadelphia
|Philadelphia, Pennsylvania, United States, 19104
|Childrens Oncology Group
|Philadelphia, Pennsylvania, United States, 19104
|Saint Christopher's Hospital for Children
|Philadelphia, Pennsylvania, United States, 19134
|Children's Hospital of Pittsburgh of UPMC
|Pittsburgh, Pennsylvania, United States, 15224
|United States, Rhode Island
|Rhode Island Hospital
|Providence, Rhode Island, United States, 02903
|United States, South Carolina
|Medical University of South Carolina
|Charleston, South Carolina, United States, 29425
|Palmetto Health Richland
|Columbia, South Carolina, United States, 29203
|BI-LO Charities Children's Cancer Center
|Greenville, South Carolina, United States, 29605
|Greenville Cancer Treatment Center
|Greenville, South Carolina, United States, 29605
|United States, South Dakota
|Sanford USD Medical Center - Sioux Falls
|Sioux Falls, South Dakota, United States, 57117-5134
|United States, Tennessee
|East Tennessee Childrens Hospital
|Knoxville, Tennessee, United States, 37916
|St. Jude Children's Research Hospital
|Memphis, Tennessee, United States, 38105
|Vanderbilt University/Ingram Cancer Center
|Nashville, Tennessee, United States, 37232
|United States, Texas
|Dell Children's Medical Center of Central Texas
|Austin, Texas, United States, 78723
|Driscoll Children's Hospital
|Corpus Christi, Texas, United States, 78411
|Brooke Army Medical Center
|Fort Sam Houston, Texas, United States, 78234
|Cook Children's Medical Center
|Fort Worth, Texas, United States, 76104
|Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
|Houston, Texas, United States, 77030
|Methodist Children's Hospital of South Texas
|San Antonio, Texas, United States, 78229
|University of Texas Health Science Center at San Antonio
|San Antonio, Texas, United States, 78229
|Scott and White Memorial Hospital
|Temple, Texas, United States, 76508
|United States, Utah
|Primary Children's Hospital
|Salt Lake City, Utah, United States, 84113
|United States, Virginia
|Naval Medical Center - Portsmouth
|Portsmouth, Virginia, United States, 23708-2197
|Virginia Commonwealth University/Massey Cancer Center
|Richmond, Virginia, United States, 23298
|United States, Washington
|Seattle Children's Hospital
|Seattle, Washington, United States, 98105
|Providence Sacred Heart Medical Center and Children's Hospital
|Spokane, Washington, United States, 99204
|Mary Bridge Children's Hospital and Health Center
|Tacoma, Washington, United States, 98405
|United States, West Virginia
|West Virginia University Charleston
|Charleston, West Virginia, United States, 25304
|United States, Wisconsin
|University of Wisconsin Hospital and Clinics
|Madison, Wisconsin, United States, 53792
|Marshfield Clinic
|Marshfield, Wisconsin, United States, 54449
|Children's Hospital of Wisconsin
|Milwaukee, Wisconsin, United States, 53226
|Canada, British Columbia
|British Columbia Children's Hospital
|Vancouver, British Columbia, Canada, V6H 3V4
|Canada, Manitoba
|CancerCare Manitoba
|Winnipeg, Manitoba, Canada, R3E 0V9
|Canada, Nova Scotia
|IWK Health Centre
|Halifax, Nova Scotia, Canada, B3K 6R8
|Canada, Ontario
|Hospital for Sick Children
|Toronto, Ontario, Canada, M5G 1X8
|Canada, Quebec
|The Montreal Children's Hospital of the MUHC
|Montreal, Quebec, Canada, H3H 1P3
|Centre Hospitalier Universitaire Sainte-Justine
|Montreal, Quebec, Canada, H3T 1C5
|Canada, Saskatchewan
|Saskatoon Cancer Centre
|Saskatoon, Saskatchewan, Canada, S7N 4H4
|Centre Hospitalier Universitaire de Quebec
|Quebec, Canada, G1V 4G2
|Principal Investigator:
|Maryam Fouladi
|Children's Oncology Group
|Responsible Party:
|National Cancer Institute (NCI)
|ClinicalTrials.gov Identifier:
|NCT01236560 History of Changes
|Other Study ID Numbers:
NCI-2011-02616 ( Registry Identifier: CTRP (Clinical Trial Reporting Program) )
ACNS0822 ( Other Identifier: Childrens Oncology Group )
ACNS0822 ( Other Identifier: CTEP )
U10CA098543 ( U.S. NIH Grant/Contract )
|First Posted:
|November 8, 2010 Key Record Dates
|Last Update Posted:
|October 12, 2017
|Last Verified:
|October 2017
Additional relevant MeSH terms:
Spinal Cord Neoplasms
Neoplasms, Neuroepithelial
Neuroectodermal Tumors
Neoplasms, Germ Cell and Embryonal
Neoplasms by Histologic Type
Neoplasms, Glandular and Epithelial
Neoplasms, Nerve Tissue
Central Nervous System Neoplasms
Nervous System Neoplasms
Neoplasms by Site
Spinal Cord Diseases
Central Nervous System Diseases
Nervous System Diseases
Endothelial Growth Factors
Antibodies, Monoclonal
Immunoglobulin G
Angiogenesis Inhibitors
Angiogenesis Modulating Agents
Growth Substances
Physiological Effects of Drugs
Growth Inhibitors


text:
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text:
27 views of Raleigh
This hometown anthology features the work of 27 (plus two) Raleighites who create a literary montage of North Carolina's capital city in fiction, essays and poetry. Novelists, poets, essayists, journalists and even a science fiction writer capture the city in a variety of genres—spanning neighborhoods, generations, cultural and racial experiences, historic eras—reflecting the social, historic and creative fabric of Raleigh.
Contributors include Angela Davis-Gardner, G.D. Gearino, Kelly Starling Lyons, Grayson Currin, Bridgette Lacy, Rob Christensen, Amanda Lamb and Andrea Weigl. "27 Views of Raleigh: The City of Oaks in Prose & Poetry" is the fifth book in Eno Publishers's 27 Views series that features literary communities of contemporary Southern towns. Previously published books focused on Hillsborough, Durham, Chapel Hill and Asheville. Softcover, 219 pages, $15.95.
(919) 632-6893


text:
Best Moving Checklist and Tips »
Staying organized on moving day is key, and planning is a big part of it. Keep this checklist handy before and during your move to keep things stress-free.
YP - The Real Yellow PagesSM - helps you find the right local businesses to meet your specific needs. Search results are sorted by a combination of factors to give you a set of choices in response to your search criteria. These factors are similar to those you might use to determine which business to select from a local Yellow Pages directory, including proximity to where you are searching, expertise in the specific services or products you need, and comprehensive business information to help evaluate a business's suitability for you. "Preferred" listings, or those with featured website buttons, indicate YP advertisers who directly provide information about their businesses to help consumers make more informed buying decisions. YP advertisers receive higher placement in the default ordering of search results and may appear in sponsored listings on the top, side, or bottom of the search results page.
705 Natchitoches StWest Monroe, LA 71291
I would give lower than one star if possible. They were late. Didn't box anything. Left some of our stuff in the old house. Scratched our furniture.…
Serving the West Monroe Area
From Business: Get connected when you move. CenturyLink, helps make the move easier. If you need to hook up or transfer services, CenturyLink, provides an array of communication…
3003 Cypress StWest Monroe, LA 71291
106 Circle DrWest Monroe, LA 71291
The climate location is great.The manager is very friendly and helpful from the time I came in till the time I left. Location is clean and very brig…
132 Cheniere Drew RdWest Monroe, LA 71291
From Business: Climate Controlled Units Available. Well Lit, Free Locks & Secure.
1837 New Natchitoches RdWest Monroe, LA 71292
1300 N 7th StWest Monroe, LA 71291
705 Natchitoches StWest Monroe, LA 71291
1837 New Natchitoches RdWest Monroe, LA 71292
885 Industrial PkwyWest Monroe, LA 71291
1506 Siddon StMonroe, LA 71201
Set up this moving company very last minute and they did a great job. The movers showed up exactly on time and got to work. I was charged the price…
1004 N 3rd StMonroe, LA 71201
This is a great shop and they have beautiul arrangements.
506 N 2nd StMonroe, LA 71201
From Business: At M&W Transfer, LLC., customer care and satisfaction is our primary goal. We make it our top priority to deliver efficient worry free moving at a very affordable…
2802 Desiard StMonroe, LA 71201
From Business: The finest in household and office relocation. Nationwide antique, art and furniture delivery services. Warehouse receiving and storage.
502 N 2nd StMonroe, LA 71201
1506 Siddon StMonroe, LA 71201
105 Avenue Of AmericaMonroe, LA 71201
2216 Redwood DrMonroe, LA 71201
2001 Desiard StMonroe, LA 71201
3611 Halsell StMonroe, LA 71203
From Business: Ross Movers, Inc. is a family owned and operated company with more than 27 years of experience. We're fully licensed and bonded, and all our movers and truck driv…
4600 Central AveMonroe, LA 71203
5658 Highway 165 BypMonroe, LA 71202
1600 Prairie RdMonroe, LA 71202
2507 Highway 139Monroe, LA 71203
11195 Highway 15Downsville, LA 71234
114 Circle DrFarmerville, LA 71241
9712 Parallel StBastrop, LA 71220
274 Rock Corner RdDubach, LA 71235
2761 Cook RdRuston, LA 71270
197 Baxter RdRuston, LA 71270
Staying organized on moving day is key, and planning is a big part of it. Keep this checklist handy before and during your move to keep things stress-free.
Moving takes a lot of planning, and that includes knowing what your moving rights are. Read on to find more about your moving rights and what you can do to prepare.
We've put together a small list to get you started on your journey -- and the first step starts with a single box.
I would give lower than one star if possible. They were late. Didn't box anything. Left some of our stuff in the old house. Scratched our furniture. Dropped our boxes we had labeled in sharpie "Fragile". Horrible experience from beginning to end. Very sad.
Every move is different, so it's vital to choose a moving company that's right for you. The first consideration you should make when hiring these professionals is how far you're moving.
Local Moves
Depending on the moving company, local moves are typically anywhere between one and 100 miles within the same state. Local moves are less complicated to plan, both for you and the movers you decide to hire. They're typically priced based on how much you need to move, how many movers the company plans to provide and how long the job is estimated to take.
Long-Distance and Interstate Moves
Even if you're staying in the same state, you may still technically be planning a long-distance move - though the exact mileage varies by moving company, these are typically moves that are more than 50 to 100 miles long or across state or country lines. In fact, even if you're moving within the same state but you have to go through another state or country first, it's likely considered an interstate move, rather than a local one. That's because the movers are technically transferring items between state lines, which means they'll be responsible for having the correct licensing and insurance in place.
Long-distance moves are much more complicated to plan, typically requiring you to pay numerous extra expenses for everything from shipping items to renting storage space.
Are you making a big move and trying to figure out exactly how much you should plan to spend? Or are you on a tight budget and looking to hire a mover who can keep costs low? Either way, it's important to understand how exactly moving companies charge their customers.
The Move
As mentioned above, for local moves, companies will charge based on the number of movers they provide and the amount of time they'll need to spend on the project. Generally, the more rooms in your apartment or house, the more movers and time you can expect to be charged for. The price of long-distance or interstate moves, on the other hand, will be based on the amount of belongings you have - and more specifically the weight of those belongings. The heavier the boxes or items you're shipping across state or country lines, the more expensive your move will be.
Moving costs will vary greatly, depending on where you are. Local moves in a small town in the Midwest will be much less expensive than comparable moves in New York City. For that reason, it's best to do some research about the going rates in your area.
The Estimate
No matter what type of move you're making, you can reach out to prospective moving companies for estimates - this is the best way to determine how expensive your move will be based on where you live and what services you're looking for. Typically, the moving company will send someone to your home who will do a walk through of each room, making note of the furniture, valuables and other belongings in each one. Then, he or she will provide an estimate. The exact amount you pay may, however, be different from the amount declared in the estimate. That's where the type of contract comes in.
Nonbinding vs. Binding Contracts
For any move, a company will ask you to sign a contract. It's crucial to know exactly what type of contract you're signing, though, to understand how much you can expect to pay. In basic terms, there are two types of moving contracts: binding and nonbinding. Binding, as well as binding not-to-exceed, contracts are the most preferable for people hiring movers. These list an estimated price the moving company cannot charge more than. So, even if your local move takes an hour longer or your belongings are heavier than expected for an interstate move, you're still only responsible for paying a fixed amount.
Nonbinding contracts, on the other hand, have no fixed final number. Instead, they list a rate - by the hour or by the pound/kilo - and you're responsible for paying exactly how much your move costs in those terms.
Extra Costs
Keep in mind that movers provide a variety of services, many of which you may not require. These can affect how expensive your move will be. For example, a full-service move that includes packing and unpacking will be pricier than a local move that only includes loading the truck, driving it to the new home and unloading it.
For any move, there may be extra costs beyond the typical services offered. If you're asking your movers to transport large, hard-to-move items, like pianos, for instance, you'll likely pay an extra fee. Likewise, if your apartment building doesn't have an elevator or the truck has to be parked far from your home, you may be charged extra. Ask about these potential expenses when signing your contract.
Don't rush through the process of hiring a moving company. Make sure the movers you hire are dependable, reputable and the right fit for your needs.
Look for Reviews and Recommendations
When hiring movers, it's a good idea to both look at reviews online and ask your friends and family members for recommendations. Personal endorsements will go a long way toward helping you determine whether you can expect the company to do a quick and professional job.
Choose Top Candidates
As you're vetting candidates through reviews and recommendations, narrow your selection to three or four top options. Make sure the companies offer the type of move you're looking for, whether it's interstate or local. These three or four companies are who you'll contact for estimates.
Don't Be Afraid to Ask Questions
After receiving estimates, you'll have a better idea which companies are within your budget. However, this isn't the only factor you should use when choosing movers, especially for more complicated jobs. In fact, you may be willing to pay a little more to hire quality movers who can ensure the safety of your belongings. Don't be afraid to call these companies and ask questions.
During the hiring process, you want to make sure of three things: First, that the moving company is reputable and has the proper licensing and insurance. Second, that the movers are dependable, professional and committed to doing the job correctly. Finally, that the estimate provided is binding and that you're aware of any potential excess costs. With these factors in mind, here are some of the most important questions to ask a moving company:
As with any service profession, there are certain moving companies - though they are few and far between - that aren't reputable or that will try to take advantage of you. It's important to be able to recognize a scam if you come across one.
Call the FMCSA
For long-distance or interstate moves, you can easily check that companies have the proper licensing and insurance, which is a clear indication that they're legitimate. All interstate moving companies must be registered with the Federal Motor Carrier Safety Administration, so call 888-368-7238 to confirm the licenses, insurance and credentials of the movers you're considering. The FMCSA can also tell you if any complaints have been filed against a particular moving company.
Check with the American Moving and Storage Association
For both local and long-distance moving companies, AMSA is another good place to check out a company's legitimacy. Moving companies aren't required to be an AMSA member, but the ones that are have committed to the association's rules and regulations, which protect both the companies and the consumers hiring them. If a company isn't an AMSA member, that doesn't mean it isn't reputable, but an AMSA membership is a clear indication of legitimacy.
One of the most common fears people face when moving to a new home is that something they own will be lost or damaged in the process. While no company will be able to guarantee everything arrives safely, there are steps you can take to make damage less likely.
Pack and Transport Your Valuables
If you have items that are emotionally or financially valuable to you, do your best to pack and move them yourself. Keep jewelry, expensive artwork, inherited valuables and even costly electronics in your own car - that way you'll have complete control over their safety at all times.
Choose a Moving Company That Plans Ahead
Moving companies can better keep your belongings safe when the movers plan ahead. What does this mean? Many companies take extra time to measure doorways, halls and stairways to find the safest route in and out of your home. They should also provide furniture blankets, covers and moving pads to keep both your home and your belongings free of scratches or other damage.
Keep the Moving Area Safe
There are some things you can control on moving day and some things you simply can't, such as the weather. If you're moving on a snowy, icy or rainy day, keeping all of your paths, stairways and walkways clear and dry is crucial. This can help protect both the movers and the large items they're carrying to and from the truck.
The subject of tipping is relatively unclear when it comes to movers. However, there is a general rule of thumb that most people in the industry agree on: Tip your movers if they've done a good job and you think a tip is warranted.
Generally, a 5 percent tip is considered appropriate, though some people recommend paying $20 per day, per mover for basic, local moves. However, almost everyone agrees you should first do a quick walk-through of your home to check for any damage to your furniture or belongings and to make sure everything is where you'd like it to be.
If you do decide to give a tip, divide it evenly and give money to each individual, rather than giving the entire sum to the head mover and expecting it to be doled out equally. One type of tip to avoid: alcohol. It's usually illegal for movers to have bottles of alcohol in the truck or van, so tipping a bottle of wine or liquor could get them into trouble.


text:
After joining a company with strict policy for source code that all coders are only allowed to access and read code via virtual machines. I find it horrible a policy they are implementing. Let me be a crackpot of my own ideas
o I know CIA can check how many scars I have in my back, they can still hear if I am still breathing in my graveyard.
o Internet-working to me can only be secure as up to 80% for ALL cases even when they have good firewalls
o Using VM to develop large applications decreases a greate deal of performance from developers.
--I am bored---


text:
Cadillac's all-new flagship sedan, the XTS, is apparently a little confused about the difference between intern and interim. You and I both know that someone in an interim role will temporarily yet capably fill a vacant position. Meanwhile, interns sometimes stumble through tasks that might seem straightforward.
The 2013 XTS is an interim at the top of Cadillac's sedan lineup. What came out was closer to an intern.
General Motors' luxury marque has been without a flagship sedan since 2011, when the DTS and STS sedans reached the end of their life cycles. A long-rumored competitor against the likes of Mercedes-Benz' S-Class and BMW's 7 Series isn't due until 2015. Such a car would be a large, rear-wheel-drive chariot with exquisite design and construction that aspirants might hope to own when one's career and or bank account peak.
Creating one from scratch is a frighteningly expensive and slow endeavor for any automaker, so Cadillac needed a stopgap to fill the void for a few years and sit above its aging CTS and the smaller, almost-available ATS.
The XTS, which starts at $44,995, is that stopgap. But because it's little more than a very handsome Buick (sharing many components with the LaCrosse), into which GM then stuffed a pile of baubles and headaches, this Cadillac just isn't up to the task of carrying the mantle of this storied nameplate.
Take the driving experience, for example. Initially the XTS comes across as underpowered, though the 304 horsepower and 264 pound-feet of torque it wrings out of a direct-injected V-6 (the only engine available) are similar figures to other luxury cars of its ilk. Only after a bit of driving do you realize it's the six-speed automatic transmission that's getting in the way of this otherwise smooth and competent engine.
The gap between when you push on the gas and get any meaningful downshift and acceleration is immense. Using the paddle shifters might seem like a good way to circumvent this, but they work only if you've already put the transmission into manual mode. Almost every other car in memory with paddle shifters will let you use them for a quick upshift or downshift, regardless of what mode the transmission is in.
Handling is no better. In base form, the XTS is front-wheel drive, though the loaded XTS Platinum I tested had all-wheel drive as a $2,225 option. But you wouldn't know it by the way this Cadillac takes curves, plowing through them like a three-legged draft horse. I didn't test a front-wheel-drive model for comparison, true, but the way the AWD model pushes hard with understeer was unsettling.
Things are better in straight-line cruising. The XTS shuttles its charges in appropriate comfort and silence during freeway jaunts and around town errands. The ride quality is nicely regulated by an advanced suspension system called Magnetic Ride Control. Borrowed from Corvettes and Cadillac's V-series cars, the system reads road conditions by the millisecond, and adapts accordingly.
The only trouble was the massive 20-inch rims and tires on my XTS Platinum added back a minute layer of harshness the suspension was working so hard to omit.
The interior is well isolated from the noises of the world outside and is a pleasant place to spend some time. Space is plentiful throughout, particularly in the back seat where this Cadillac far outpaces competitors. I'm 6-foot-2 and could cross my legs in the back seat, even if I were sitting behind someone equally as tall. The perforated leather was butter-smooth; the cabin's construction felt solid; the trunk could hold the entire cast of "Downton Abbey."
Cadillac got this stuff right. But left plenty of room for headaches.
Like Lincoln, Cadillac decided to do away with traditional buttons to control rote tasks like the climate control and stereo volume. Instead, the XTS now relies on a touch-sensitive, back-lit panel. And like Lincoln, any appreciation for its sleek design and futuristic minimalism is immediately wiped away the first time you try to use it.
Despite haptic feedback (a slight vibration each time you touch it), the system registers perhaps a quarter of your actual touches. Want to turn down the volume quickly? Try stabbing at a flat panel for 30 seconds. Worse, this panel is decorated with silver trim that looks exactly like buttons. Sweet, glorious buttons that would do what you want them to do on the first command. Alas.
Above this ineffectual portion of the dashboard, things get better. It's there that an 8-inch screen sits, the centerpiece of a system Cadillac calls CUE (Cadillac User Experience). It's a touch screen (also with haptic feedback) that integrates the navigation, stereo, climate and Pandora streaming radio systems. It's designed to be more user-friendly than other comprehensive systems, and enables users to interact with the screen as they would a tablet like Apple's iPad.
Unlike the panel below it, the CUE system responds to inputs well, though a modicum of patience and a deliberate touch is needed. One particularly neat trick is how the screen senses you reaching for it, and will display a mini menu of commands at the top only when your hand is close.
Cadillac took all this content, and then stuffed it into a rather handsome exterior shell. The hood and front overhangs don't have the elongated, romantic proportions of rear-wheel-drive cars, but given what Cadillac had to work with, this is a very bold and dramatic package. The front is dominated by a wide and proud chrome grille and headlights that sweep back onto the front quarter panels. The taillights pay homage to the fins of yesteryear by protruding from the surrounding metal of the very short trunk lid.
Yet the bearers of such baroque styling cues many decades ago were indeed flagships for Cadillac. A standard that today's XTS falls short of. It's a good-looking, overly ambitious and often ineffectual entity.
An intern indeed.


text:
Get involved in FeedReader.
Hi, and thank you for your interest.
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The translation project for FeedReader into മലയാളം currently contains 221 strings for translation and is 0.0% complete.
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text:
Making sense of the brain's mind-boggling complexity isn't easy. What we do know is that it's the organ that makes us human, giving people the capacity for art, language, moral judgments, and rational thought. It's also responsible for each individual's personality, memories, movements, and how we sense the world.
All this comes from a jellylike mass of fat and protein weighing about 3 pounds (1.4 kilograms). It is, nevertheless, one of the body's biggest organs, consisting of some 100 billion nerve cells that not only put together thoughts and highly coordinated physical actions but regulate our unconscious body processes, such as digestion and breathing.
Parts of the Brain
The brain's nerve cells are known as neurons, which make up the organ's so-called "gray matter." The neurons transmit and gather electrochemical signals that are communicated via a network of millions of nerve fibers called dendrites and axons. These are the brain's "white matter."
The cerebrum is the largest part of the brain, accounting for 85 percent of the organ's weight. The distinctive, deeply wrinkled outer surface is the cerebral cortex, which consists of gray matter. Beneath this lies the white matter. It's the cerebrum that makes the human brain—and therefore humans—so formidable. Whereas animals such as elephants, dolphins, and whales have larger brains, humans have the most developed cerebrum. It's packed to capacity inside our skulls, enveloping the rest of the brain, with the deep folds cleverly maximizing the cortex area.
The cerebrum has two halves, or hemispheres. It is further divided into four regions, or lobes, in each hemisphere. The frontal lobes, located behind the forehead, are involved with speech, thought, learning, emotion, and movement. Behind them are the parietal lobes, which process sensory information such as touch, temperature, and pain. At the rear of the brain are the occipital lobes, dealing with vision. Lastly, there are the temporal lobes, near the temples, which are involved with hearing and memory.
Movement and Balance
The second largest part of the brain is the cerebellum, which sits beneath the back of the cerebrum. It is responsible for coordinating muscle movement and controlling our balance. Consisting of both grey and white matter, the cerebellum transmits information to the spinal cord and other parts of the brain.
The diencephalon is located in the core of the brain. A complex of structures roughly the size of an apricot, the two major sections are the thalamus and hypothalamus. The thalamus acts as a relay station for incoming nerve impulses from around the body that are then forwarded to the appropriate brain region for processing.
The hypothalamus controls hormone secretions from the nearby pituitary gland. These hormones govern growth and instinctual behavior such as eating, drinking, sex, anger, and reproduction. The hypothalamus, for instance, controls when a new mother starts to lactate.
The brain stem, at the organ's base, controls reflexes and crucial, basic life functions such as heart rate, breathing, and blood pressure. It also regulates when you feel sleepy or awake.
The brain is extremely sensitive and delicate, and so requires maximum protection. This is provided by the surrounding skull and three tough membranes called meninges. The spaces between these membranes are filled with fluid that cushions the brain and keeps it from being damaged by contact with the inside of the skull.


text:
Spatial ALD lends itself perfectly for optical stacks for multi-layer optical band-pass filters. Because ALD layers are build up atom by atom, the level of control over layer thickness is very high and is determined by the number of deposition cycles. Exactly this is needed for multi-layer interference filters.
The following shows a practical example demonstrating the level of agreement between the theoretical optical performance of an ideal band-pass filter and the actual product made by ALD technology.
A three layer coating consisting of Al2O3 and TiO2 was deposited on PET foil by a R2R ALD tool with the goal of achieving maximum reflectance at 550 nm. The ALD process is based on the use of TiCl4+H2O and TMA+H2O as process gasses at a deposition temperature of 100°C.
The result was a very uniform reflective coating with maximum reflectance at 550 nm. As can be seen in the graph below, there was a near perfect fit with calculated theoretical model.


text:
Anne Hathaway - AFI Awards 2013 Red Carpet
Anne Hathaway makes her entrance at the 2013 AFI Awards held at the Four Seasons Hotel on Friday (January 11) in Beverly Hills, Calif.
The 30-year-old actress is wearing an Oscar de la Renta dress, her own coat, and a Stella McCartney belt underneath.
Anne's film Les Miserables is one of the ten films being honored at the ceremony this afternoon.
The night before, Anne attended the Critics' Choice Awards, where she picked up the award for Best Supporting Actress. During her speech, she called out the awards show for spelling her name wrong on the screen!


text:
HI dive buddies out there. This trip leaves Melbourne, Australia - but land content only is also a possibility.
Just thought I'd let you all know that I have some vacancies in a group departure diving Siladen Island (off Manado) in Bunaken Marine Reserve June 26 - July 6 2009. We are staying at fabulous Siladen Resort and Spa, which is a quite a luxurious setup though we get it at a very good rate (our second trip after we had a group of 32 in 2008. Checkout www.siladen.com which has a video on the resort - what you see is what you get - it really lives up to the promo very well. I can comfortably recommend this resort very highly after one of our best trips ever in 2008. And the diving is just so interesting. Everything from big Green Sea Turtles to tiny Pygmy Seahorses. The trip leaves from Melbourne - other airports by arrangement.
AIRFARE: Melbourne / Singapore/ Manado / Singapore / Melbourne Singapore Airlines Group
Carlton Hotel Singapore 1 nights accommodation twin share
All transfers
Siladen Resort:
8 nights accommodation gardenview or beachfront bure
All mealsfull breakfasts, gourmet buffets, beach barbecues
Welcome drink upon arrival plus 1 hour massage per person Siladen
Free I hour Introduction to SCUBA session for all non-divers
Gardenview triple share $2680 per person
Gardenview twin share $2850 per person
Beachview triple Share $3025 per person
Beachview twin share $3130 per person
Child 2-11Yrs (sharing with adults) gardenview $1410 per child
Child 2-11 yrs (sharing with adult) beachview $1595 per child
Child 12-16 years(sharing with adult) gardenview$2045
Child 12-16 years(sharing with adult) beachview $2270
DIVE PACKAGE - $400 for 11 boat dives per diver - tanks/weights/air fills, dive guide services
Plus Taxes:$425.00 per adult; $380.00 per child
If interested, simply e-mail me, Alan Wiggs at email@example.com
Looking for dive buddies - North Sulawesi July 2009
Started by Wiggsy, Apr 08 2009 10:44 PM
No replies to this topic


text:
Should Investors Fear 'Dark Pools'?
Following news of a settlement with the SEC, Colin Barr joins Markets Hub to offer a look at "dark pools" and how they impact investors. Photo: Getty Images.
This transcript has been automatically generated and may not be 100% accurate.
... I ... he he he seems to a Wall Street all we have the front page story on dark pools ... outdoor pool overnight so I can sleep yesterday was fined by the ICC about eight hundred thousand dollars ... for ... not being dark and and so what is this and what is what happened Renault Diego enough or maybe being too dark and and and how you'll continue in the delegation is that this this company ... um which of the offers something new and is so they're they're they're a lot of interesting Firms the go go these companies will fall off I we have well Poland these sorts of new platforms that that they used to trade stocks ... don't issues that they ... do ... you trade a dark pool because he won a better price you want to give you have your orders doing other people's orders and then ... discos We Baptist boy you will get you the best price the best X the fastest execution ... audio issue here is that this company did a lot of it did not keep peoples who was confidential which allowed other people potentially to trade against them ... and we've been doing a whole series about this Wall Street Journal The talks about this the sorts of conflicts of interest that happened in trading ... where oh Euphrates change the law and the moral aquatic and all kinds of anything sprung up with these these pools ... in the question is ... are they doing what they see they're doing ... we've we've had in the dark pool ... this issue we have to see Brian had to hearings in last week ... we've had a bunch of ... glitches from night to the flash drive two thousand had benefited from an investor who was just looking thoughtful specifically shoddy worry about how much a part they are ... of the market given ... the all or a mechanism that we still don't know what time about being the only been around for so I think it's right well I think the one to one of the issues were grappling with now is how much do we actually know about them as opposed to what we've been told about them ... know something that was true couple told you about ... the whole financial industry in the run-up to the crisis is that you can do the things that people can back expansion financial industries from the way that things develop ... always told us was well ... here we're not can have a problem because people have incentives to do to do the right thing essential you markets markets Act to make the people the right thing then turned out that was true when we start to see some that with these dark pools in some these electronic arrangements ... is that there are no was ... one of the surest ways make a profit is to do so something else's expense knows that that that seems to be sure what's going on ... is interesting to hear even ... in the midst of it here even some of the proponents of ... equity trading and dark pools above ... if we had to do it all over again we wouldn't have created the market that we have today write one of these events was clear is ... the fragmentation you've got where near forty dark pools ... you've got five major exchanges you've got all these different venue is right up pushing against each other for for trading right for transparency for different order types write is there any way that we can look across what the market has become a had a chance of regulating and making sure Investors guerrillas really good question and I met the part of the problem ... is the import of this ... stems from the fact that everybody involved markets now is that is do Sul a for profit basis me Class B had exchanges where ... they were mute rules and they were and they had an incentive in the sense to police people because he is to think about the long-term ... you try make changes in the for profit operators in yes they still have a rental poured function trapped in many cases that the incentives to stay in the mean of everybody's them the incentive is the stain is to make ... to make more trades to make the market bigger ... than any sort of half things growing like weeds and nobody quite understand how they interact with each other and that's when you end up sprawled on ... the call that is so much for joining us please make sure to read ... more from Colosseum which has been all over the story from day one I'm the Money Investing section ... also read more on to Vishay dot


text:
February 1, 2005
Dear Mr. Donaldson,
Instead of creating a division between brokers and investment advisers based on the nature of the services they offer, this SEC rule proposal would expand the brokers exclusion from the Advisers Act to include instances in which the broker receives special compensation for advice. This is exactly the wrong direction for the agency to be taking.
The broker/investment adviser distinction is important for investors, because investment advisors are subject to a higher standard of conduct than brokers. While advisors have a fiduciary duty to place their clients interests ahead of their own, brokers are subject to a less exacting obligation to make suitable recommendations. Brokers are required to make some disclosure of conflicts of interest, but those requirements are neither as timely nor as extensive as the disclosure requirements that apply to investment advisers.
Investors need to know that all financial professionals who offer investment advice are subject to the same rules. To accomplish that, the SEC must define solely incidental advice, and it must do so in a way that limits such advice to the sort of buy this/sell that recommendations which are an inherent part of the brokers sales function.
Michael A. Potito, AVA


text:
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Bruce Willis: 'Die Hard' Mural Unveiling with Jai Courtney!
Bruce Willis attends the unveiling of a mural commemorating twenty-five years of Die Hard on the side of Soundstage 8 at the Fox Studio Lot on Thursday (January 31) in Century City, Calif.
The 57-year-old actor was joined by his A Good Day to Die Hard co-stars Jai Courtney, Yuliya Snigir, and Rasha Bukvic.
PHOTOS: Check out the latest pics of Bruce Willis
Be sure to check out A Good Day to Die Hard when it hits theaters on February 14. Make it an action-packed Valentine's Day!
FYI: Jai is wearing an Ermenegildo Zegna suit. Bruce is wearing Dior Homme.
Bruce Willis – "Die Hard" Mural Unveiling
20+ pictures inside of Bruce Willis and Jai Courtney at the mural unveiling…


text:
Start off by shunting heavy loads on rails, then skip off the tracks and drive on the road to where the next rail task awaits you. Only one vehicle can do this – the Mercedes-Benz Unimog road-railer.
Great pulling power: with the Unimog road-railer you have a fully fledged shunter at your disposal. It is perfectly adapted for a hauling capacity of up to 1000 t. It is equipped for exceptional ease of operation and comfortable driving. Not only do you save up to 60% on the purchasing cost over a conventional shunting locomotive, you also save significantly on fuel and other service products. And you save additional money in maintenance, service and intermediate/main inspections. The Unimog's direct on-track/off-track capabilities help to save you time and money. Simply drive the Unimog on the road to the next job and transfer it to the tracks again using a lifting and pivoting system in a matter of minutes. All you need is an embedded track section of approx. 5 metres in length.
As a professional equipment carrier, the Unimog road-railer can also be utilised for a huge range of tasks within the rail track infrastructure. From cutting back overgrown trees to track cleaning and maintenance, from maintaining overhead lines to clearing snow from the tracks. You can also convert the Unimog for work operations away from the track, e.g. a winter service vehicle for your plant site.


text: Digital artist and Volumist.Photography was first my passion, computer science my profession. My need for creation then naturally turned towards the expression of the crossbreeding between photographic art and digital art.Like a DJ, I mix, I interlace the images, the shapes and the colors that oppose and harmonize, evoking a rhythm, an energy, an emotion.Recently and just as naturally, it is in plastic art that I express my creativity differently. Between my fingers are born small, light and voluptuous characters.Contemporary and primarily aesthetic, my work is inspired by an intuitive need to recover, mix and transform the existing.


text:
Mr. Gravid: "No."
Lady Gravid: "Yeah, I have one."
Dr. Grumpy: "Go ahead."
Lady Gravid: "Do you mind if I look through your patient charts before we leave?"
Dr. Grumpy: "Uh, yeah, I do. They're medical records. I can't allow that."
Lady Gravid: "Oh, I don't need to read them, I just want to look at patient names."
Dr. Grumpy: "Okay, but I still can't allow that. Sorry."
Lady Gravid: "Please? We're trying to think of baby names, and I don't like any I've seen so far."


text:
Brittany (French: Bretagne, Breton: Breizh; [1]) is a diverse region of northwestern France.
The region is subdivided into four administrative départements:
Other destinations
Breton islands:
Anglo-Norman islands (British Crown dependencies):
Brittany received its modern name when it was settled (in around 500 AD) by Britons, whom the Anglo-Saxons had driven from Britain. Breton history is one long struggle for independence — first from the Franks (5th-9th century), then the Counts of Anjou and the Dukes of Normandy (10th-12th century), and finally from England and France.
The Breton people maintain a fierce sense of independence to this day, as displayed by their local customs and traditions.
In the past 5 years or so a resurgence of the regional identity has happened in France. Breton art, music and culture are recognized across the nation. France has now accepted that in diversity lies strength and unity.
The people of Brittany all speak French, many speak the regional Breton language Breton, and many speak English very well. While France tried to discourage the use of regional languages their use is rebounding, bringing a stronger understanding of culture, contributions, and history. Through the local efforts of the Bretons and the DIWAN Breton Language schools, children are being tought in the native language while they learn standard curriculum. The DIWAN schools are supported by world wide efforts through various groups, including the International Committee for the Defense of the Breton Language.
Get in
By ferry
Jersey and Guernsey to St Malo
Plymouth to Roscoff and Portsmouth to St Malo
Brittany Ferries[2] operates the following regular services:
By plane
There are airports in:
By train
The TGV train runs almost hourly from Paris Montparnasse to Rennes, Brest and Quimper.
By car
The A11, the Océane Route, links Brittany to Paris. A dual carriageway runs from Rennes to Nantes, and there is a motorway from Nantes to Bordeaux.
All roads in Brittany are free! No peages.
France Car Hireis a great way of getting around if you are on a budget.
By bus
SNCF offers bus services from all major rail stations in Brittany.
Get around
In Brittany, all roads are free (no tolls).
Stay safe
When swimming in the sea, watch out for rips and undercurrents. Be mindful that the tide can come at a very fast pace soatch out or you might be stranded on an outlying island! Check the tides (marées) in your local tourist office. Ask for a table of the tides.
Get out


text:
Kittehz 4 Sale on ur haiwhey
Here's a property coming on the market that you don't see every day. The Cats estate in Los Gatos is for sale. It's right off Highway 17 just a mile south of downtown Los Gatos, next to the The Cats Restaurant & Tavern. Thanks very much to Burbed reader Kir from Inside Los Gatos for passing this item along.
More info, and videos, are at the agent's site. The property is nine separate parcels consisting of over 75 acres of land, with three different originally built houses. Views galore, of course. It can be yours for $8,995,000.
Facts and Features
Main House:
3985 Square Feet
Built in 1925
5 Bedrooms
4 Bathrooms
Remarkable Valley Views
Finished Basement-perfect for wine cellar
View Amphitheater
Terraced Courtyard
Famous collection of notable "attached" art work
Additional Buildings:
The Gatehouse
The Poet's Cottage
The Ranch
The Geodesic Dome
The Teacher's House
Additional Features:
Gated entry featuring the famous Stone Cats
Riding/biking trails
Poet's Canyon
The secret benches
The round bench
Superb acreage for horses
Natural splendor, a photographer's paradise
Natural springs
Suitable for vineyards
Mountain, valley and lake views
Chain of ownership:
Charles Erskine Scott Wood & Sara Bard Field
Fred G. Hampton
Ogilvie Family
Does nine million seem like the right price for a property like this? Think of all the fun you'll have with everyone who ever knew you in elementary school dropping by because "they were in the neighborhood."
This is the gatehouse above right. Below is the main house.
All these pictures were snagged from the videos on Duane Adam's site. Below left is a view inside the main house, and below right is the Poet's Cottage. The latter gives just a taste of the views from the property. Plenty more in the videos, plus footage from the 1930s!
Watch the daughter of the current owner get all choked up over the property being sold. She says whoever gets the property will be "very lucky," so why didn't they price it at $8,888,888?
One thing we did discover that isn't on Adam's site: the actual address. If you bought the Cats Estate, you'll be receiving your mail at 17525 Santa Cruz Hwy, Los Gatos, CA 95033.


text:
In this series, I am providing pictures of tombstones from Latvian cemeteries, all with death dates prior to 1945. I do not have any further information on the people mentioned.
Photo taken by me, April 2012. Click to enlarge.
Name: Eduards Lazdiņš, born February 15, 1886; died October 26, 1926.
Inscription on reverse: "Reiz Jūsu starpā dzīvoju, bet tagad dusu – sapņoju" ("Once I lived among you, now I sleep – dream")
Location: Meža kapi ("Forest Cemetery"), Rīga.
Tombstone Tuesday – Eduards Lazdiņš, 1886-1926


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The Town of Holden Recreation Department is accepting registrations starting August 1 for the before- and after-school programs at Mayo, Dawson and Davis Hill Schools for September. Registrations will be accepted on a first-come basis. Licensed by the state Department of Early Education and Care, the programs are offered to children in grades K-5. The morning program runs 7:30-9 a.m. and the afternoon program from school dismissal to 6 p.m. Juice is provided in the morning, juice and a snack in the afternoon.
To register or for more information, call the Recreation office at (508) 829-0263.
The Recreation Department is accepting applications for employment in the two programs. Applications are at the Town Manager's office, Starbard Building, 1204 Main St. and the Recreation office, 175 Highland St.