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Subcutaneous implantable multiple-agent delivery system
Subcutaneous implantable multiple-agent delivery system
Patent Drawings:
(2 images)
Date Issued:
April 13, 1993
May 3, 1991
Giampapa; Vincent C.
(Montclair, NJ)
Primary Examiner:
Rosenbaum; C. Fred
Assistant Examiner:
Polutta; Mark O.
Attorney Or Agent:
Silverman; M. K.
U.S. Class:
Field Of Search:
International Class:
U.S Patent Documents:
Foreign Patent Documents:
3317536; 2621248
Other References:
There is provided an implantable multiple-agent delivery system which includes a pod proportioned for subcutaneous implantation beneath the dermis of the skin, the pod including a porous surface having at least one internal chamber there within which is in fluid communication with the porous surface. The system further includes a dome proportioned for complemental, selectable detachable securement upon the pod. The dome includes a plurality of interior chambers, each in fluid communication with the internal chambers of the pod. Bio-acting agents, such as hormones, biologic response modifiers, free radical scavengers, and other therapeutic agents may be provided, within the chambers of the dome, prior to implantation. Such agents with the chambers of the dome will, through the use of time release microelectronics, enter at least one of the interior chambers of the pod for transmission, through the porous surfaces thereof, into a growth factor stimulated capillary matrix and then to the bloodstream of the user. The pod may be removed, refilled, and resecured to the dome upon exhaustion of its contents or upon medical requirement for changes in medication. The surface of the pod may be treated with one or vascular growth factors or related biologic molecules.
Having thus described my invention what I claim as new, useful and non-obvious and, accordingly, secured by Letters Patent of the United States is:
1. A subcutaneously implantably, multi-agentdelivery system, comprising:
(a) a pod for subcutaneous implantation beneath the dermis of the human body, said pod comprising a porous surface between an interior and exterior thereof and, further comprising, fluid transfer means in fluid communication with said poroussurface, said pod having an opening at the top thereof, said pod formed of a bio-compatible material, said porous surface between said interior and exterior of said pod provided with one or more vascular growth factors to promote growth of bloodcapillaries into and about said porous surface of said pod;
(b) a dome portioned for complemental detachable securement within said opening of said pod, said dome including at least one chamber having selectable fluid communication with said fluid transfer means of said pod, in which bio-acting materialsmay be stored within said chamber of said dome prior to implantation, said dome formed of a biocompatible material, attached to said pod; and
(c) time dependent material release means interfaced between said chamber of said dome and said fluid transfer means of said pod,
whereby said bio-acting materials are controllably released from said chamber of said dome, into said pod and, therefrom, through said porous surface into the bloodstream, in which said dome, after exhaustion of the materials therewithin, may beremoved, refilled and re-secured to said pod.
2. The system as recited in claim 1 which said vascular growth factors are selected from the group of growth factors consisting of vascular endothelial growth factor, platelet growth factor, vascular permeability factor, basic fibroblast growthfactor and transforming growth factor beta,.
3. The system as recited in claim 1 in which said pod is formed of a silastic material having a porous vascular ingrowth characteristic.
4. The system as recited in claim 3 in which said silastic material is selected from the group consisting of silicone and polytetrafluorethylene.
5. The system as recited in claim 1, in which said material release means is situated within an axial central core of said dome.
The present invention relates to the field of implantable vascular prosthetic device, more particularly, to subcutaneous implant for integration into the vascular/capillary system of a patient for purposes of selectable dispensing, over anextended period of time, of pharmacologic and other bio-acting agents.
A problem which has developed in contemporary pharmacology and areas of bioengineering is that many bio-acting molecules resultant from such efforts are of a size, length, weight and complexity such that they are subject to attack by theenzymatic processes within the digestive tract when such drugs or bio-engineered agents are taken enternally (orally). Further, the state-of-the-art of encapsulation and matrixing of drugs to minimize the effect of digestive tract acids, and to extendthe release period thereof are, generally, limited to a number of hours in the resultant effective time period of release of such agents.
Recognizing the above limitations of orally delivered bio-acting agents, and realizing the limitations of drug delivery by means of hypodermic injection, a number of approaches, by way of implantable micro-infusion pumps/dispensers has appearedin the art. More particularly, such micro-pump and micro-dispensing systems have included electro-chemical means, piezo-electric means, osmotic means, of both an active and passive nature, and miniaturized classical electro-mechanical delivery means. All of these technologies have, as their goal, the provision of extended time-release of drugs and other bio-active substances directly into the bloodstream of the patient. For example, U.S. Pat. No. 4,886,514 to Maget relates to an implantable,electro-chemically driven drug dispenser capable of achieving dispensing rates in the range of 0.01 ml per hour to as low as 0.001 ml (one microliter) per hour.
Implantable piezo-electric systems, intended for long-term dispensing of bio-acting agents are represented by U.S. Pat. Nos. 4,938,742 to Smits and 4,944,659 to Labbe. These technologies are entirely solid state and, therefore, are, inprinciple, capable of unlimited miniaturization and to control thereof by purely electronic means. Thereby, long term, low quantity delivery systems should be achievable by such means.
The category of so-called active osmotic pumps is represented by U.S. Pat. No. 4,898,582 to Faste which employes chemo-mechanical processes which do not require any source of electrical energy, such as a battery. In this technology, a membraneis reciprocated responsive to a chemical reaction to, over extended periods of time, provide controlled, long-term release of bio-acting substances.
So-called passive osmotic pump systems have appeared for use in both oral and have been suggested for subcutaneous delivery systems. Such pumps, which often involve the use of lipids, are represented by U.S. Pat. Nos. 4,111,201 to Theeuwes;No. 4,439,196 to Higuchi; and No. 4,685,918 to Amidon et al. Passive osmotic pumps make use of a rigid enclosure having an expandable compartment which over time, supplies pressure against an adjacent second compartment to effect pressure gradientagainst the wall of the second compartment such that, over prolonged period of time, a bio-acting agent within the second compartment will be forced across an aperture in the rigid enclosure and into the bloodstream or tissue of the patient. Suchsystems of osmotic drug delivery an address of drug delivery rates of picoliters per hour, that is, billions of liters per hour. Accordingly, it is believed that extremely low quantity and prolonged delivery rates are achievable through the use of suchosmotic systems. Nonetheless, such approaches do not address the needs of the patient or user having, as is often the case, the requirement for a timed, sequenced, and/or pulsed delivery of a number of different bio-acting agents, often known asbiologic response modifiers. Also, little is known regarding the long term effect of osmotic systems, when such systems are with subcutaneous implants.
A further concern in the area of implantable delivery systems is the ability of the vascular system to provide sufficient volume, rate, and pressure of blood flow to the delivery means in order to enable the bio-acting agents to enter thebloodstream on a reliable basis. Two approaches to this problem have appeared in the art. One is the approach of Powell, (see U.S. Pat. No. 4,929,442) of providing an improved physiological carrier to permit the particular bio-acting agent to becomemore effectively transferred to the bloodstream. A second approach to the problem of access of the agents to the vascular system is reflected in U.S. Pat. No. 4,820,626 (1989) to Williams et al, which is concerned with methods of treating the surfaceof subcutaneous implants with microvascular endothelial cells to better integrate the implant into the vascular system of the patient to achieve better bloodflow to the dispensed agents.
The instant invention is an improvement of the said technology of Williams in that use is made of one or more of a combination of so-called vascular growth factors which communicate directly with the so-called angiogenesis gene which, it isbelieved, is the basis of all human vascular development. Accordingly, through the use of growth factors, and related biological molecules which have been recently discovered, vascular growth, of capillaries, veins, and the like, upon the surface of animplant can be stimulated. This has been demonstrated by Ogawa, and others, who has placed a vascular growth factor within an osmotic pump capsule, subcutaneously implanted the same, thereby, stimulated the growth of capillaries and related vascularmaterials which are identified with vascular growth and development.
Also there has appeared in the art such materials as polytetrafluoroethylene having specially configured fibers, fibrils and other structures adapted for vascular implantation. Accordingly, a combination of synthetic and organic materials haveappeared in recent years, which in one fashion or another, stimulate vascular growth and/or activity.
The instant invention builds upon the above advances in molecular biology and microelectronics. It more particularly provides for a selectably detachable component of a dispensing system in which a permanently implanted vascular portion of thesystem cooperates with a replaceable component thereof within which various biologic response modifiers, and other, agents may be provided and dispensed at low rates and for prolonged periods into the implanted vascular portion and therefrom into thehuman body.
There is provided an implantable multiple-agent delivery system which includes a pod proportioned for subcutaneous implantation beneath the dermis of the skin, said pod comprising a porous surface and having at least one internal chamber therewithin which is in fluid communication with said porous surface. The system further includes a dome proportioned for complemental, selectable detachable securement upon said pod, the dome comprising a plurality of interior chamber, each having fluidcommunication with said internal chambers of said pod. Bio-acting agents, such as hormones, biologic response modifiers, free radical scavengers, and other therapeutic agents may be provided, within the chambers of said dome, prior to implantation. Each of said chambers will, through the use of time release means, enter at least one of said interior chambers of said pod for release, through the porous surfaces thereof, into the stimulated vascular matrix and into the bloodstream of the user. Saiddome may be removed, refilled, and resecured to said dome upon exhaustion of its contents or upon medical requirement for changes in medication. The surface of said pod may be treated with one or more vascular growth factors or related biologicmolecules.
It is accordingly an object of the present invention to provide a subcutaneous vascular implant for purposes of extended time release delivery of a plurality of bio-acting agents.
It is another object of the present invention to provide a vascular implant having a component thereof which may be selectably removed, refilled with medication, and resecured to a permanently implanted vascular portion of the system.
It is a further object of the present invention to provide a means in nature of a prosthetic gland from which needed hormones, related agents and combinations and can, over a prolonged period of time, be released into the bloodstream.
The above and yet other objects and advantages of the present invention will become apparent from the hereinafter set forth Detailed Description of the Invention, Brief Description of the Drawings, and Claims appended herewith.
FIG. 1 is a perspective, schematic view of the inventive system prior to implantation.
FIG. 2 is an exploded view of the system.
FIG. 3 is a side conceptual view of the system after implantation.
FIG. 4 is a top cut-away view of the internal compartments of the dome, taken along Line 4--4 of FIG. 3.
FIG. 5 is a perspective conceptual view of the system implanted within the dermis.
FIG. 6 is a cross-sectional view of FIG. 1, taken along Line 6--6 of FIG. 1.
FIG. 7 is a bottom view of the inventive system.
With reference to FIGS. 1 and 2, the inventive system may be seen to include a pod 10 having a diameter preferably in the range of 1 to 3 centimeters. As such, it is proportioned for subcutaneous implantation beneath the epidermis 12 and dermis22 see FIGS. 3 and 5. The surface of pod 10 contains a multiplicity of pores 14 and, as well, at least on internal chambers 16 which, through fluid transfer means 17, such as a capillary mesh, is in fluid communication with said pores 14. The walks ofpod 10 are formed of a porous silicone or polytetraflorothylene to permit ease of ingrowth of capillaries within tissue layer 18 and at subcutaneous border 20.
In a preferred embodiment, the porous surface of pod 10 is treated with one or more vascular growth factors, or related biologically active materials which operate to communicate directly with the angiogenesis genes of nearly cells which, it isbelieved, are responsible for all vascular development. Accordingly, growth factors and the like may be viewed as genetic "receivers" while the angiogenesis genes operate as a genetic transmitter. A number of vascular growth factors have beenidentified. These are vascular endothelial growth factor (VEGF), platelet derived growth factor (PDGF), vascular permeability growth factor (VPF), basic fibroblast growth factor (bFGF), and transforming growth factor beta (TGF-.beta.). Relatedmolecules which operate in a similar fashion may also be used. These are known cytokines and gangliosides.
The use of endothelial cells upon the surface of a prosthetic device, employed in the context of vascular surgery, is known as is taught in U.S. Pat. No. 4,820,626 (1989) to Williams et al entitled A Method of Treating a Synthetic or NaturallyOccurring Surface with Microvascular Endothelial Cells. Instant invention, however, does not relate to the use of a growth factor treated surface in the context of a surgical device or system. Rather, said pod 10 operates as a permanently implantedcomponent of a long term multi-agent drug delivery system. Its effectiveness is maximized by reason of its placement at the subcutaneous border 20 of the patient, this constituting the location of greatest blood flow. As such, it is an ideal locationfor any agent dispensing device which relies, for its efficacy, upon permanent access to a relatively consistent of level of blood flow. As may be noted in FIG. 3, the subcutaneous border 20 is defined by the interface between dermis 22 and tissue layer18. Between dermis 22 and epidermis 12 is the dermal layer known as stratum germinativium 24.
It is established in the literature that capillary growth may be artificially generated through the implantation of vascular growth factors upon the surface of an implant. See for example, Ogawa et al, "Transforming Growth Factors Beta One andBeta Two Induce Synthesis and Accumulation of Hyluronate and Chondroitin Sulphate In-Vivo", 3 Growth Factors 53-62 (1990). Further, the medical literature concerning growth factors contains over 200 papers on the subject of vascular growth factorspublished between 1989 and early 1991. Accordingly, the technology of the use of vascular growth factors to stimulate artificial capillary growth is known in the art.
The present drug delivery system further includes a dome 26 (see all figures) which is proportioned for complemental, detachable securement on top of pod 10 and, more particularly, within the inner circumference 28 of annular region 30 of the pod10. Said dome 26 and pod 10 may be secured through the use of bayonnet lock elements 31 and 33 of the type shown in the exploded view of FIG. 2.
As may be noted in the radial cross-sectional view of FIG. 6, the interior of dome 26 comprises a plurality of interior chambers 32 each having fluid communication with fluid transfer means 17 of said interior chamber 16 of pod 10. Also shown inFIG. 6 are vertical fluid transfer means 33 which communicate with said mean 17.
As may be noted in the view of FIG. 3, the top of dome 26 will reach through dermis 22 and will stop at epidermis layer 12.
In another embodiment, the top of dome 26 may protrude above epidermis 12 in the manner taught in U.S. Pat. No. 4,552,561 (1985) to Eckenhoff, entitled Body Mount Pump which teaches the use of an implantable pump having a transparent topthrough which the contents of the dome portion may be seen.
In either embodiment, an essential concept relative to the instant invention is that a plurality of bio-acting agents may be placed within compartments 32 of dome 26 and, after their exhaustion, or upon the election of the physician, dome 26 may,through minor out-patient surgery, be removed from pod 10, refilled, and then re-secured to pod 10.
With reference to FIG. 4, the various radial and polar segments shown within compartments 32 of dome 26 are shown to represent the time release aspect associated with the bio-acting agents within the compartments 32 of dome 26. Moreparticularly, any one or more, either singularly or in combination, of the technologies discussed in the Background of the Invention may be employed to effect time release of the bio-acting agents through vertical fluid transfer means 36 (see FIG. 6) toinner chamber 16 of pod 10 and, thereby, through pores 14 of tall sides of he pod and into the blood at subcutaneous border 20.
The potential technologies for effecting extended duration time release run the gamut from substantially passive means such as osmotic pumps to electrochemically driven drug dispensing means (see Maget, discussed in the Background of theInvention), to systems requiring use of a battery 36 (see FIG. 4 and 6) acting as a source of low level power to a piezo-electric micro pump and micro valves, such valves operating within chambers 32 of dome 26, as is generally taught in the referencesto Smits and Labbe, discussed in the Background of the Invention. Such solid state piezo-electric means are particularly suitable where small rates of release, e.g., nanoliters per hour, over a period of months, is required.
The instant invention may also be practiced through the use of relatively crude subcutaneous implant devices such as that reflected in U.S. Pat. No. 3,443,561 (1960) Reed, entitled Subcutaneous Implant Device, previously used in veterinaryapplications, as the pod 10 of the present system. Accordingly, long known implants of the type of Reed may be equipped with a dome, as above described, to thereby provide for an extended time release capability of a plurality of a bio-acting agents.
In broad concept the instant invention may be viewed as a prosthetic gland in that, through its operation, a sustained release of hormones of various types, including, human growth factors designed to increase muscle mass, decrease body fatdeposition, and stimulate immunological responses, may be employed. More generally, such hormones are known as biologic response modifiers and, generally relate to those classes of agents which have been determined to be associated with the agingprocess or immune system. More particularly, the absence or decrease of hormones and/or their growth factors as well as free radical scavengers have been identified as a primary cause of the aging process. To use the above transmitter/receiver analogy,the operation of the human gene may be compared to that of a transmitter, while the operation of growth factors and related molecules may be viewed as genetic receivers or receptors. In other words, the aging process is now believed to be the result ofa failure in one or more of the genetic processes of transmission and reception of genetic information. The avenues by which genetic instructions travel from genes to growth factors is often termed the enzymatic pathways. More particularly, certainenzymes are associated with the operation of so-called messenger DNA which communicates genetic instructions from the gene to the growth factor where the instructions of the gene are then executed in the particular tissue with which that growth factor isassociated. Growth factors or hormone regulated processes, which affect of an enzymatic pathway may be purely local to the cell (an autocrine pathway) or the genetic instruction may be delivered at a considerable biological distance (an endocrinepathway).
In that genetic research has, as yet, been unable to locate any so-called aging gene, it is believed that most manifestations of the aging process occur as a result of breakdown in either or both the enzymatic pathways or of the actual growthfactors which to execute the genetic instructions. More particularly, in vitro experiments have shown that most genes have the capability of reproducing tens of thousands of times this corresponding to what would relate to dozens of normal lifespanspecie generations. It is therefore now believed, that most aspects of aging are a result of the inability of cell classes within tissues to continue to execute genetic instructions, that is, it is now widely believed that aging, as it is presentlyunderstood, is primarily a result of the failure of cells to carry out essential genetic instructions from genes which, in and of themselves, appear to be capable of functioning indefinitely.
As a more modest goal of what has become known as growth factor therapy, certain diseases which cause a more dramatic manifestations of the aging process can, through the system of the present invention, be directly treated. For example,osteoporosis which is directly related to growth hormone deficiency can be treated; similarly, certain areas of the skin and related fat deposits which are generally associated with aging, may be treated through the use of epidermal growth factors whichhave been identified including the above mentioned fibroblast growth factor (bFGF) which is generally associated with the growth of muscle mass.
Further, one popular theory of aging is the process known as glycolysolation in which certain compounds causes a cross linking of certain proteins thereby rendering the above referred to enzymatic pathways less sufficient. Accordingly, throughthe use of hormones and other molecules, such as free radical scavengers, such cross linking or glycolysolation of proteins necessary for healthy enzymatic pathways, can be effectively eliminated.
The important role of growth factors in combating diseases, such as carcinomas and anti-viral diseases, is recognized by Powell, in U.S. Pat. No. 4,929,442 (1990) (see Background of the Invention). He discusses the importance of glycoproteinsand growth factors in the combating of certain topical and subcutaneous conditions. Further, Powell teaches a physiologically acceptable carrier which in the instant invention and, more particularly, within the chamber of dome 26, may be employed toincrease the effectiveness of other bio-acting agents which may be employed within the scope of the present invention. Further, through the use of vascular growth factors in at least one of the chambers 32 of dome 26, the vascular growth factor appliedto pores 14 at the surface of pod 10 will co-act to provide long term "nourishment" to the vascular growth factors applied to the surface of pod 10 and to the artificially created capillary growth (see FIG. 5) within tissue 18.
Persons suffering from high cholesterol may be effectively treated through the use of Lovastatin and other anti-cholesterol drugs which are more effective when delivered in small quantities over an extended period of time. Further, even personshaving a normal cholesterol level can benefit from the use of such anti-cholesterol agents to decrease age related arterial damage as well as to provide improved oxygenation to the entire central nervous system as well as to other vital organs. Accordingly, within the scope of the present invention, it is anticipated that persons not considered ill by earlier medical standards, will be able to make advantageous use of the instant system.
Further, there exists numerous medical therapies in which one drug or drug system is optimally employed in combination with a second or many other drugs such that a desired synergistic effect can be achieved. For example, U.S. Pat. No.4,971,951 (1990) to Garcia y Bellon et al, teaches a therapy known as Insulin Potentiation Therapy which has application to numerous diseases. In the practice of Insulin Potentiation Therapy the effect of the particular therapeutic or bio-acting agentis potentiated by the parental injection to the patient, approximately 20 minutes prior to the administration of the therapeutic agent, of a prescribed dosage of insulin. In other words, the action of the therapeutic or bio-acting agent of interest ispotentiated, within the intracellular compartment, that is, the permeability to cross the cell membrane is enhanced, by a "pulse" of insulin at a prescribed time prior to the administration of the therapeutic agent, (which in the case of insulinpotentiation therapy involves the combination of glucose or dextrose with the therapeutic agent) must occur. As such, the present system will be particularly useful in that one compartment 32 within dome 26 may contain a material such as insulin which,through the use of electronic means as is taught in the references to Smits supra and others, may be pulsed into the subcutaneous border 20 at a programmed period of time prior to pulsing from one or more other compartments of dome 32 occurs.
More generally, through the instant invention, a physician such as endocrinologist may prescribe a number of hormonal, therapeutic and other bio-acting products having a variety of different volumetric, molaric and temporal time releasespecifications. Further, the respective compartments 32 of dome 26 may be equipped with any of a variety of biological sensors such that the electrical, chemical or mechanical delivery means, as the case may be, are initiated in response to a particularindication which may be monitored through blood flow in tissue 18 within the region of said artificially stimulated capillary ingrowth 38.
It is to be further appreciated that, within the scope of the present invention, compartments 32 of dome 26 may be provided with pre-packaged time release elements such as bio-acting materials contained within silicone tubules as a presently aremanufactured and sold by the Leiras Medical Corporation of Helsinki, Finland. A number of such implantable tubules now exist for the release of birth control acting hormones. However, such tubules may be equipped with other hormones, therapeutic agentsand the like as above discussed, and the geometry thereof adapted for implantation within the polar and radial segments of compartments 32 of the dome 26.
Accordingly, while there has been shown and described of the preferred embodiment of the present invention it is to be appreciated that the invention may be embodied otherwise than is here and specifically shown and described and, within saidembodiment, certain changes may be made within the form and arrangement of the parts without departing of the underlying principles of this invention as set forth in the Claims appended herewith.
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UV radiation and ozone
Solar radiation is the radiation emitted by the sun. The electromagnetic spectrum of the sun has its highest intensity in the range of visible light.
Depending on its wavelength, solar radiation varies in terms of intensity and spectral distribution due to absorption and scattering while entering the earth's atmosphere. In addition, the intensity of solar radiation reaching the earth's surface, i.e. the "subaerial solar radiation", strongly depends on climatic conditions and solar altitude.
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The biological effectiveness of this radiation component is very high, and even small variations of the ozone content in the stratosphere, therefore, substantially influence the danger potential of sunlight at the earth's surface.
State of 2018.09.13

subset: commoncrawl


text:
It has been a week since the cowardly murders at Newtown, Conn.
It has been a week since the cowardly murders at Newtown, Conn. I stood back and watched to see where the hysteria is going to take us. As I expected, it was to arm everyone in the classrooms and other staff. That is ludicrous (and I�m a gun advocate).
The staff of Sandy Hook did all the right things (did you notice that Sandy and Sandy Hook is not a good name for the Northeast). They made sure that their charges were safe. They took as many precautions and then some to protect these children. They kept the children calm, focused, and assured. In the end, some of the staff gave their lives, wow! (Mr. President, where is the Medal of Valor for them and the Medal of Merit for the rest). I don�t think there is anyone that could enhance these actions, they could do no more.
A few good words for the school districts, they took all the precautions they could with the information they had to date. By the way, this includes the local districts. I did some checking, not testing. I don�t feel like going to jail or causing alarm.
So what can we do?
First, let�s make it clear what is needed is time � time to secure children and staff, time to notify police and any first responders, time for staff to check everything out, time to mobilize the world, if needed, to come to their aid.
We should start with the entry. Let�s get rid of the glass and replace it with resistant plastic (the degree is up to the district) and keep the doors locked. Any person coming will be on tape and told to I.D. themselves and open any coats, then buzzed in. All doors are to be taped. The staff office will be at the front door, not down the hall. At the office, there will be a second set of doors. After checking in with the staff, they can be buzzed in further. (I know they are doing most of that but I have to start some place.)
All other doors should also be plastic and entry resistant. They should also have panic alarms on them. When they go off, the staff goes into protection mode. If the alarm is set off maliciously, the punishment should be certain and severe. How are we going to know who did it? Have a luminous under black light powder or paint coating on it. The key is to slow the entry and alert the staff.
Why do the teachers need to be told of a lockdown? They are trained adults. If they hear a noise that is violent, or even the door alarms, go into lockdown for their class, secure the children while locking the door and then check with the office. If they err on the side of precaution, so what. Why do they need the office to sound the alarm first? Train the staff and empower them, and a different alarm should be used for fire danger.
Place two deadbolt locks on each door in addition to the door locks, not too high so the children can open them if needed or if scared. Make the glass in the doors small and re-enforced.
Place kickout panels in some of the windows to be used as an escape of last resort. Teachers will know when to use them. Designate an assembly area, unlike a fire drill, away from the school (a tough concept). Multiple targets running from the area are hard targets to hit, as opposed to confined in a classroom. I love some of our schools with the outside doors.
If the extra door alarms are activated, notify police. They might just be going to a false alarm, or in route observe the offenders leaving the scene. No harm.
Continue to hold fire drills. They are the greatest defense there is. However, hold aggressor drills (I think for drills, terror is just a little much). Let the children know what is expected of them and what their responsibilities are as students. Even give them some empowerment over the other students to re-enforce what they know, sort of a little bit of peer pressure to keep them in line.
Hold not just one or two drills a year, but hold one a month to re-enforce and update what they have been taught. Hold impromptu conversations or quizzes about what to do.
There are many important entities that need activating. The most important however is time. Slow down the perpetrators and activate the defenses. Let�s face it, these people are bent on getting in and they want to hurt and will hurt people.
I did hear one thing during the interviews that troubled me. One of the teachers that secured her children explained that "the bad guys are out there, we have to wait for the good guy." One child replied "I know karate follow me." How brave. To the teachers of karate, please let them know it does not stop bullets.
For those of you wondering who is this guy, I�m a retired police lieutenant. I spent 25 years with the NYPD, eight of those years with the Emergency Service Unit. We were those guys running in with the long guns. During 1977, I became an EMT and an AEMT. My last four years was as the administrator of the busiest precinct in the city. I had four schools in the district with 15 officers assigned to the detail. I�ve also spent 10 years as a volunteer firefighter. I guess one could say I might have a better than working knowledge of the problem before us. Unfortunately, only a few answers.
Tony Michalek, Harlowe


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Thursday, June 17, 2010
Women's bodies and the men's World Cup - Pretty women help lose games
Isn't that nice.
Apparently, Sara Carbonero is dating the Spanish goalkeeper, Iker Casillas, who gave up the match's only goal in the game against Switzerland. The win by Switzerland was a huge upset, and Casillas' mistake is being blamed, by some fans, on Carbonero whose presence was known to her boyfriend and may have potentially been a distraction.
This kind of reaction is ridiculous. Making a conventionally attractive woman a scapegoat for the loss of a game that was played by men not only provides reason for undue scorn against a woman who was doing her job, but it also perpetuates the stereotype that when men see a pretty woman, they lose all self-control and can't help but, you know, lose a World Cup match.
I would also like to add that if you watch the replay of the goal scored by Switzerland, it is clear (to me at least) that it was not a matter of Casillas being distracted by his girlfriend, during which time a goal slipped by. He made a bad decision which had bad consequences.
Part one in my World Cup series.
2 comments:
Just wondering, do you know that it has been a long time tradition of major football teams to limit, or ban visits from wives and girlfriends? The Brazil football team practiced this so that the players will be fully rounded in the world of football, football, football. Mexico is another team that has recently followed this suit. Would you call this sexist - that woman are inherently, a form of distraction for men, or would you call this a form of isolationist training (sorry, made that word up since I could not think of any other) to demand the best of the best from the players? I understand that this piece is not directly connected to what you wrote, but that news about the Spanish journalist sparked this thought.
- June 21, 2010 at 1:45 PM
- Amelia said...
I am vaguely aware of the practice that you mention here, but I cannot say I know the details.
My take on such a tradition would depend on exactly what it entailed. Are wives and girlfriends the only people the players are banned from seeing (or allowed to see in limited amounts)? Are the players only supposed to socialize/work with the other players on their team and no one else? Where is this practice most common, and what is the human rights' record of those places? I also wonder if this practice is limited to national teams, or if it ever applies to club teams?
Such details would help determine a proper way to consider the tradition, because with my limited knowledge of the practice, it could potentially be viewed either way: as sexist, or as a logical form of training.
- June 21, 2010 at 3:04 PM


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Disclaimer unlock nokia 6680
I did not write any of this information, it is summarized from various sources. I am not responsible for any damage you may cause to you, your phone, or your computer. Credit for most of this work belongs to Dejan Kaljevic and the various posters on gsmhosting.com
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It didn't work!
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If I power on the phone first and let it start up completely, by inserting the cable phone says enhancement not supported and making log fails.
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My phone is a BB5 phone, but not on the list of phones that can be unlocked with Dejan's software. What can I do?
If your phone is locked to Vodafone UK you can try this:
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"Miltenberg" is a town with a medieval flair. Worth visiting is the famous "Schnatterloch" with its ensemble of buildings at the "Old Market" and the historic market well. Another attraction is Castle "Mildenburg". It lies about 150 m above the town of Miltenberg. With few exceptions, the system is well preserved. You can visit the castle courtyard, the curtain wall with battlements and the "Bergfried".
Nikon D5000 | Nikkor 18-135 | Panoramic Tripod Head homemade | 38 Pictures | ISO 1600 | 1/500 sec. | F3,6 | 18mm | PTGui | PaintShop Pro
Wikipedia: Franconia (German: Franken) is a region of Germany comprising the northern parts of the modern state of Bavaria, a small part of southern Thuringia, and a region in northeastern Baden-Württemberg called Heilbronn-Franken. The Bavarian part is made up of the administrative regions of Lower Franconia (Unterfranken), Middle Franconia (Mittelfranken), and Upper Franconia (Oberfranken).Franconia (like France) is named after the Germanic tribe of the Franks. This tribe played a major role after the breakdown of the Roman Empire and colonised large parts of medieval Europe.Modern day Franconia comprises only a very tiny and rather remote part of the settlement area of the ancient Franks. In German, Franken is used for both modern day Franconians and the historic Franks, which leads to some confusion. The historic Frankish Empire, Francia, is actually the common precursor of the Low Countries, France and Germany. In 843 the Treaty of Verdun led to the partition of Francia into West Francia (modern day France), Middle Francia (from the Low Countries along the Rhine valley to northern Italy) and East Francia (modern day Germany). Frankreich, the German word for "France", and Frankrijk, the Dutch word for "France"; literally mean "the Frankish Empire".


text:
Ben to Heath Miller!
14-7 Ravens at the half. Nice to see them move the ball for a change.
21-7 Ravens now.....our defense and secondary is playing awful today.
Our offense is playing mad slow and can't convert.....this is frustrating and aggravating.
Bullshit ruling on the field and after review! Parker was down before the ball came out of his hands!!!
no, that ball was out before his knee was on the ground. oh well now the season is really over. 21-7 with 8:30 left.
pathetic play by morey there. he needs to get cut.
hopefully wilson will get cut as well. wow he just got owned by mcallister.
Correct me if I'm wrong, but isn't the STEELERS' defense known for moving around, confusing the QB, and coming with disguised blitzes?
And, with such a defense, isn't it true that opposing teams have, at times, had success against us using various different tactics to neutralize our defense?
So, doesn't it make sense that we would know EXACTLY what works against this kind of defense, what it's weaknesses are, and how to play against it?
If so, WHY THE ****ING HELL DON'T WE KNOW WHAT THE **** WE'RE DOING AGAINST THE GODDAMMED ****ING RAVENS!?!?!?!?!?!??!?!?!?!?!!?!?!?!?!?!?!??!?!?!?! ?!?!??!
a couple of nice grabs by holmes here. about time roethlisberger and holmes got on the same page.
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text:
Créativité et Communication : étude de cas "Storytelling"
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The Digital Rocking Chair's curator insight, September 3, 2015 11:06 AM
Joe Berkowitz: "Filmmaker and D&D devotee Matthew Robinson talks about what screenwriting and the fantasy roleplaying game have in common."
Pierre Mongin 's curator insight, July 5, 2015 11:07 AM
Une excellente utilisation de de CmapTools Qui is available Gratuitement sur Ipad et sur PC et sous Mac. Seule la synchronisation entre les deux coûte 4€ une fois pour toutes !
Dominique Taste's curator insight, July 6, 2015 12:06 PM
Une carte succincte qui rappelle quelques points clés du storytelling visuel, mais sans utiliser d'éléments visuels ou émotionnels. L'auteur indique les logiciels gratuits utilisés pour le composer.
Jessica Kelly's curator insight, March 24, 2015 10:59 PM
What's pareidolia, and why does it matter in terms of brand storytelling/framing? If you don't know, you will as soon as you read this very interesting, informative, useful (and several other positive adjectives) post. Bonus: As the title indicates, you'll also read about three storytelling categories--reinforcer, supporter, and challenger. Yep, it's a good post.
Dr. Karen Dietz's curator insight, March 26, 2015 7:35 PM
Do you know what pareidolia is? Do you know about framing and how it connects to pareidolia? Do you know the 3 types of brand messages to use?
If you answered "no" to any one of these, you are going to want to read this article. Written by branding professional Laura Petrolino, she takes us deeper into successful brand storytelling.
Understanding what pareidolia is and it's link to storytelling is crucial. From there you can to better framing, and then move on to improved messaging.
Dig into this article if you want better brand storytelling for your business. The only thing I wish the author had done for us is give us a few brand storytelling examples. Hopefully next time. That being said, the information here could still make a world of difference for you.
This review was written by Karen Dietz for her curated content on business storytelling at www.scoop.it/t/just-story-it
The Digital Rocking Chair's curator insight, March 26, 2015 7:04 PM
CMF Trends: "Interactive storytelling has entered a phase of negative perception, but transmedia author Michel Reilhac believes that this is just a temporary lull. New media is being perfected in the wings."


text:
|2013-03-10, 16:48
|Link #122
Join Date: Mar 2013
They still have 42 (give or take) minutes to cover what's left. They could manage it. There's gonna be a lot of action now and in animation it goes a lot faster and I still think they could add some kind of confession or something of that sort to show us Saki and Satoru love each other.
And I mean how much time does it take to say "I love you, Satoru!"
Last edited by Moeterumoe; 2013-03-10 at 17:10.
|2013-03-10, 17:08
|Link #123
Join Date: Mar 2013
Spoiler for novel:
|2013-03-23, 20:55
|Link #128
Senior Member
Join Date: Oct 2007
Location: ¯\(º_o)/¯
From the General Discussion Thread, pg 37
|2013-03-24, 22:06
|Link #131
Senior Member
Join Date: Dec 2004
Right, as for the end of the book.
Spoiler for what the anime didn't get into (though it hinted at it):
|2013-03-27, 13:28
|Link #138
Junior Member
Join Date: Mar 2013
Shinsekai Yori Potential Professional English Translation!
For all of you waiting and hoping for an English translation of the novels, Here's a company willing to do it if they reach a certain amount of interested people. (around 4,500 they previously stated.)
In order to promote this translation, you must live in the US, UK, or CANADA, have a tumblr account, and "Like" the original post. Which can be found here:
Here is more information about it:
Please like and share with people you know might be interested! We're already at 1,017 likes. We can do it!
|2013-05-17, 10:23
|Link #139
Senior Member
Join Date: Sep 2011
Someone said that in the novel, Saki and Satoru both imagine they're having sex with Shun while they're having sex with each other. Is that true? Because if so, lol. That seems extremely unhealthy. Yes, he was their childhood love and yes, he was tragically torn away from them and their memories were played with, so maybe they didn't have time to cope with his loss in a normal way. (Satoru said as much in the anime.) But still, I think it's sad that after all they've been through together that they're still obsessed Shun to the point where they have to picture him while they have sex. So, I really hope the person who said that was just making that up.
Last edited by YayPepsi; 2013-05-17 at 10:34.
|2013-06-17, 07:50
|Link #140
Senior Member
Join Date: Dec 2004
^No, it's true. It happens after they lose Maria & Mamoru, and if you pay attention to the timeline it's only a few months after Shun's death. If you think of the stress and the emotional mess they both are in that moment, having lost two more people whom they loved, it's not that surprising that they both end up thinking of the boy they both still love (even though their memories of him are blocked). Yes, it's messed up and unhealthy, but there you have it.
Note again this happens BEFORE the 12 year time skip, and for all we know it could've been a one-time occurrence. (If you ask me it probably was.)
|Thread Tools


text: There is a post available on XDA with links to the latest Droid 4 Leak. You can either follow that thread or use the tool I've written here to update to the latest leaked version. [HOW TO] Install the leaked Android 4.0.4 ICS build on the Droid 4 (XT894) - xda-developers I have created and tested an update utility that will pre-flash GB 219 files to your phone plus the 215 leaked kernel enabling you to update to this latest version using the recovery option on the phone. The tool is available below for windows only. However, you can easily read through the batch file and copy/paste the commands to a console in Linux provided you have the phone tools installed. This assumes you have updated your phone before and know how to extract and copy the "blur...." file from the leak archive to your phone. It also assumes you know what CMD is and at least how to navigate the directory structure using a drive letter and/or the cd command. You'll need a copy of the latest DROID4 leak 6.16.215 available here: https://docs.google.com/open?id=0B5YH1w-_H3yCRWNEMmJCeU9GX0U Unpack and copy the blur...zip file to your phone sdcard. You'll need a copy of the 6.16.215 kernel ONLY at one of the links below: http://db.tt/TyJDblmf http://droid.trbailey.net/dropbox/215 kernel/boot-6-16-215.img This will be flashed to your phone, no need to copy it to the sdcard. You'll need a copy of the Gingerbread 219 OTA update available at one of the links below if you don't already have one: FileFactory Premium http://sbf.droid-developers.org/cdma_maserati/VRZ_XT894_6.5.1-167_DR4-1_M1-219_1FF_01.xml.zip http://droid.trbailey.net/dropbox/VRZ_XT894_6.5.1-167_DR4-1_M1-219_1FF_01.xml.zip You'll need a copy of the UPDATELEAK tool here: http://droid.trbailey.net/dropbox/UPDATELEAK.zip Unpack the tool and read through the README.txt file. Copy necessary files from GB 219 to the UPDATELEAK directory. Copy the boot image for .215 to the UPDATELEAK directory unless you saved it there. Double check you copied the leak update to your sdcard Connect phone via USB, enable USB debugging, set USB mode to "camera". Run "menu.bat" and enter "1", then read the prolific warnings and answer "y" to continue. After flashing BEFORE REBOOTING with phone still in ap-fastboot mode... Run CMD (windows command prompt) and enter final command to write boot image. (tool supplies the command or see below) NOTE you must navigate to the UPDATELEAK directory in cmd for the flash tool to find the boot image and work properly. This command writes the target boot image to the phone. Reboot phone and wait while it updates (you will see animated android and progress bar). Wait some more... Turn off phone (down vol and power buttons) then re-start in bootloader mode (both volumes plus power) Select Recovery, Install from SDcard then select the 215 update file on phone and let it install/update. NOTE: If you see the red broken android animation and/or don't see the vertical menu with update from sd on it you may need to hit both volume keys to get it. This tool requires you to enter and run a single command using CMD. The final command is: fastboot flash boot boot-6-16-215.img (assuming you are installing ICS 215 leak) After it finished and you observe the word "writing" either manually reboot or enter: fastboot reboot via CMD. Enjoy.


text:
Earth Island Institute
Home › Project Support › Start a Project
Start a Project
"We recently attracted the notice of a large foundation; they would never have looked at a group our size if we were not part of EII. It provides name recognition and credibility with donors and other supporters."
–Alyson Ewald, The Altai Project
Project Support
Video by Jim Garcia Media
Earth Island Sponsorship includes:
- 501(c)(3) Status: Allows the project to receive tax-exempt donations from individuals and foundations.
- Community: Opportunities to interact with and learn from peers.
- Recognition: Gain public notice by joining a highly regarded organization with 30 years of experience.
- Stability: Gain institutional strength by becoming part of a $15 million organization.
- Earth Island Journal: Earth Island's award-winning magazine provides an excellent project outreach and donor development tool.
- Web site: Build an internet presence within Earth Island's popular Web site.
- Finance: Earth Island provides central accounting services, including monthly financial statements and custom reporting.
- Employee Services: Payroll processing and benefit management.
- Fundraising Support: Access resources and receive guidance on fundraising efforts.
- Skills Training: Participate in periodic training sessions focused on building capacity of the project.
Earth Island Institute's Project Support Program provides an opportunity for committed individuals and groups with a good idea to launch a project with us, or to gain sponsorship for an existing project. This model is an efficient alternative to having dozens of separate nonprofits working in isolation and spending precious resources duplicating basic administrative functions.
Starting and running a non-profit organization requires a great deal of administrative and logistical effort. This effort limits the time and energy that can be applied toward actually carrying out program objectives. Our Project Support Program eliminates this obstacle by providing projects with non-profit status, administrative services, training, technical assistance, and a peer community. In addition, we provide our projects with assistance in planning, public outreach, fundraising, and other resources and services that maximize the effectiveness and quality of our collective efforts.
For more information, visit About Project Support.
Sponsorship Eligibility & Selection Criteria
The following conditions must be met in order to be considered for project sponsorship:
- Earth Island Institute provides sponsorship to projects that support our environmental mission and are consistent with our 501(c)(3) nonprofit status.
- New projects should plan to stay at Earth Island for at least one year.
- Project Directors must have regular access to phone and email in order to maintain communication with Network Services staff.
- In general, projects must have a US-based representative and / or base of operations (see 'Note Regarding International Projects" below).
- Projects must agree to conduct all business through Earth Island Institute and relinquish any pre-existing 501(c)(3) status.
In reviewing project applications, we consider the necessity of the project within the broader environmental movement, the capacity of the project's leadership, and whether it's a good fit with our existing projects. The following questions are illustrative of the kind of things we look at in each of the categories.
- Is there a need for this project? Is this need clearly stated? Is the approach innovative?
- Does the project have the capacity to successfully implement this project? Is there access to resources (money, time, expertise)? Have the project directors illustrated an appropriate knowledge of the field?
- Is the project a good fit for Earth Island Institute? Does the project support our organizational mission? Will it fit within the organizational culture? Are there opportunities for collaboration or for conflict with existing projects?
Note Regarding International Projects
Because effective two-way communication and an ability to attend periodic Earth Island events are critical to successful delivery of the services that Earth Island Institute provides to its projects, we generally will not consider projects without a US base of operations.
That said, many of our projects are working on international environmental issues together with groups based outside the United States. Organizations located outside the US are encouraged to contact existing EII projects directly regarding collaborative opportunities.
The Project Application Process
To launch an Earth Island project you must apply through our Program Committee. The process works as follows:
- Project applicants should review the Earth Island Web site, familiarizing themselves with what existing EII projects are working on and with EII's project support program — including a review of the Benefits and Responsibilities of Sponsorship and the Memorandum of Understanding.
- Project applicants should then contact EII staff to discuss the project and review any questions the applicant may have.
- Complete the New Project Application.
- The staff and Program Committee review the application and make a recommendation to the Board of Directors.
- The Board of Directors makes all final decisions whether to accept or decline a project.
Approval Timeline
Our Program Committee and Board of Directors review new project applications quarterly. Applications received by the stated deadline will be considered during that review period. Although exceptions to this schedule may be made in special circumstances, please use this schedule as a guide to the application process and plan accordingly.
PLEASE NOTE: the below calendar reflects changes in the review schedule which will start with the Winter 2014 review cycle.
Review Cycle
Review Cycle
Review Cycle
Review Cycle
|Submit complete application to Susan Kamprath at: Earth Island Institute, 2150 Allston Way, Suite 460, Berkeley CA 94704
|June 1
|September 1
|December 1
|March 1
|Program Committee reviews application and makes recommendation to the Board of Directors.
|Board of Directors reviews and decides on application.
|If project approved, New Project Orientation in Berkeley (2 days).
Application Forms
Please make sure you closely read and complete all of these documents.
For more information, please contact Susan Kamprath, Director of Project Support, Earth Island Institute: 510-859-9107.


text:
Mobility: A Tough Nut to Crack
Mobility may be all the rage, but companies are finding that building and supporting effective mobile apps presents some significant challenges.
By Tony Kontzer
At last week's AppsWorld North America conference in San Francisco, it was clear that the pace of the mobile revolution is presenting challenges for every type of enterprise.
"Mobile computing has outstripped everything that came before in computing," Brian McLaughlin, a technical fellow and IT architect at Boeing said. "Enterprises are trying to respond as best they can to the oncoming crush."
The way McLaughlin sees it, many companies overthink their mobile business apps, injecting them with too much technical wizardry and not enough practical usefulness. Hence, two of his most persistent messages were to focus on a company's biggest pain points and never lose sight of the people who will be using the apps.
Along those lines, General Electric Aviation has established a clear-cut set of evaluation criteria that ensures mobile apps meet basic requirements in areas such as simplicity, user control and insightfulness. The goal, said Eduardo Cocozza, executive director of mobility at General Electric Aviation, is to inject the enterprise with the same ease of use offered by consumer apps.
"What we're really looking to do is let people do work where the work is," Cocozza said.
That's precisely what CIO Dominic Nessi is trying to accomplish at Los Angeles World Airports, which operates Los Angeles International and two other L.A.-area airports. Nessi is overseeing an ambitious four-stage rollout of mobile infrastructure that will eventually enable airport employees, service providers and contractors to use their mobile devices for tasks such as submitting work orders, tracking power outages and shutdowns, and accessing security video feeds.
That Nessi is rolling the effort out in multiple stages speaks to his recognition of the effort's complexity.
"I'm very, very risk averse. I'm taking this very slowly, I admit that," Nessi said. "But three or four years from now, we will have every enterprise app extended via a mobile app."
It's not just mobile enterprise apps that pose significant challenges. Companies as tech-savvy as the National Football League and The Onion have also found the mobile landscape confounding.
In the NFL's case, the league finds itself torn between its desire to give fans all-consuming apps and its financial obligations to the television broadcasters who pay dearly for rights to games. That conflict is proving to be a significant obstacle to the league's efforts to provide fans with a compelling second-screen experience.
"When you're making billions of dollars from the television business, you don't want to do anything to jeopardize that," said Manish Jha, the NFL's mobile chief.
Meanwhile, The Onion's challenge is a bit clearer. Michael Wnuk, director of technology, said the site's mobile app isn't getting enough traction to attract advertisers. "We really don't know what to do," Wnuk admitted.
These companies' travails were summed up quite succinctly by Prashant Sridharan, a developer advocate at Facebook who talked about how mobile apps can take advantage of the social media giant's platform. "Building an app," said Sridharan, "is insanely hard."
About the Author
Tony Kontzer has been writing about technology and business for nearly 20 years and currently freelances from his home in the San Francisco Bay Area. Having spent the dot-com boom and bust years in Silicon Valley, he's had a front-row seat during the evolution of the technologies of today's IT-powered business. He has been a regular contributor to CIO Insight and Baseline since 2007.
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Live Blog of orders: November 14, 2011
This morning, beginning at 10 a.m. Eastern, the Court is expected to issue orders from the November 10 Conference, which we will cover in the Live Blog below. Once you see the Live Blog window and our initial welcome, we ask that you do not refresh your browser. Updates will appear without the need for refreshing. We will begin live-blogging at approximately 9:55.
Recommended Citation: Kali Borkoski, Live Blog of orders: November 14, 2011, SCOTUSblog (Nov. 14, 2011, 9:47 AM), https://www.scotusblog.com/2011/11/live-blog-of-orders-november-14-2011/


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Search results for: Bf Videos Film
Bf Videos Film
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Related searches:
Webotopia provides a business directory designed to promote Bf Videos Film companies, products and services whilst helping it's users find the Bf Videos Film information they need. Webotopia business directory, with the help of it's dedicated support specialists and reviewers, enables delivery of Bf Videos Film quality content, excellent customer support as well as value added services such as content publishing and press releases for it's users.


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Zingg's Karate
Give us a call!
The American Kempo-Karate Association Okinawan Tozan-ryu Karate The International Kempo Federation
Commando Krav Maga
Beginner and Advanced Classes
Monday: Gracie Jiu-jitsu Basics (to Blue Belt) 9pm - 10pm
Tuesday: CKM Basic 8:30pm - 10pm (Level 1 & 2)
Wednesday: Gracie Jiu-jitsu Advanced Above Blue belt) 9pm - 10pm
Thursday: CKM Advanced (Level 3 and above)
Friday: Private training by appointment
Saturday: 8am-9am - Open Mat
9am - 10:30am Women's CKM
10:30am - 12 noon CKM Basics
12 noon - 1:30pm CKM Advanced
Sunday: Private training by appointment:
Boot Camps, Private training, Semi-private training
Seminars, Testing, Special Training
Mr. Dennis Stoika
Commando Krav Maga Level 6 Instructor
Zingg's Karate welcomes you to our website!
Zingg's Karate Center,
111 West Second Avenue, Suite B,
Ranson, West Virginia 25438
Thank you.
Robert Zingg
visit: www.onthemat.com


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Mrs 'H', our long serving marsh harrier female, has returned for her ninth season on the reserve. She has been seen displaying with a male and appears to be gathering nest material. A great time to see amazing mid-air food passes.
On Thursday April 4th at 9.21pm the tawny owl in one of the boxes on the reserve showed a first glimps of three owlets tucked underneath her leaving one egg to hatch. Today the fourth egg shows sign of hatching but mum is sitting tight and it is difficultto see what is going on.
A bittern is being spotted regularly on the reserve; there have been two seen and apparently displaying. Fingers crossed, they may stay to breed this year.
After the long spell of easterly winds it will be lovely to have some warmer weather though this will mean that we have to say goodbye to the winter migrants that have been here in numbers We have played host to huge flocks of brambling this winter and there are still good numbers tobe seen. On the other hand we are looking forward to the summer visitors. The first chiff-chaff arrived two weeks ago and has recently been heard singing.


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China Says No More Movies And TV Shows About Time Travel
from the don't-even-think-about-it dept
It sounds like time travel stories had become especially popular in Chinese media, and it sounds like someone at the Bureau just got sick of it. Along similar lines, the Bureau has apparently also declared that no more TV/movie versions shall be made of "the four great classical novels of China." Honestly, it really feels like someone (or some people) involved in this Bureau just got sick of seeing similar shows and decided to issue a ban.
Of course, the real question is how long will it take for people in China to create a video that involves going back in time to restock the General Bureau of Radio, Film and Television with people who seem less silly?


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April 2013 Dispatch - Jeep News & RumorsPosted in News on April 1, 2013
Jeep News & Rumors
• Jeep Australia put a pic of a girl in a Jeep wearing a shirt that read "I love Marine boys" and a bikini bottom on its Facebook page. Jeep Australia then removed a pic of a girl in a Jeep wearing a shirt that read "I love Marine boys" and a bikini bottom on its Facebook page. Jeep Australia quickly deleted it after users complained it was sexist. Otherwise, we'd of course have posted it for you to enjoy.
• Fiat's plants in Italy will go through a redo in order to be able to export Jeeps and other brands, not just Fiats. For ages now, the plants haven't been building all they're capable of handling.
• And Fiat still intends to build a downsize Jeep no one else has ever seen before, available for both the U.S. and Europe.
• The Wrangler was named "Hottest 4x4-SUV" at the '12 SEMA Show. It's "hot" because it's considered a model with a good platform for accessories and other aftermarket products, not because it was set aflame.
• No pressure, but if the diesel Grand doesn't sell well, it might mean death to diesel for all American Jeeps.
• Jeep recall: close to 800,000 '02-'04 Grands and '02-'03 Libertys for "inadvertent airbag and/or pretensioner deployment."
Quote Without Story
"Now that the election is over, watch Chrysler ship Jeep production to China—my prediction."
—Donald Trump via Twitter
"You are full of shit!"
—Ralph Gilles, VP product design at Chrysler and CEO SRT and SRT Motorsport, responding via Twitter
Industry News
• The Chrysler Trenton Engine Plant scored a tax abatement from Trenton, Michigan, to bump up production and expand the plant. It would build even more Pentastar V-6s and Tigershark inline-fours.
• And there's so much demand for the '13 Ram, the Warren Truck Plant is increasing shifts.
• In 2012, Chrysler had its best October sales since 2007.
• Collector Car Appreciation Day: The fourth annual one will happen July 12, 2013. It's a fest that fests auto restoration and collection.
• The SCORE Baja is 45 years old.
• Interested in becoming a Stay The Trail Ambassador in Colorado? It's a volunteer program that promotes proper OHV use and teaches trail ethics. More info is at staythetrailambassadors.org and staythetrail.org.
Auto Graphs
• GM and Disney are taking Walt Disney World Resort visitors behind the scenes of automotive design. The Test Track in Florida's Epcot will allow people to create their own designs, explore the design process, and get virtual and stuff. They can also test drive the vehicle they designed on track surfaces and also race it over extreme and ever-changing terrain, as well as much more.
• Ozan K. Tonguz, a telecommunications researcher at Carnegie Mellon, is on the cusp of solving our problems with traffic—through his studies of how bees and ants avoid gridlock.
• Paul McCartney's (or at least once owned by him) '64 Aston Martin sold for $496,613 at the RM Auctions auction in London.
• The HondaJet: It's in production.
Jeep Patriot Freedom Edition
The Wrangler Freedom Edition now has a compatriot—the Patriot Freedom Edition. It's available in, naturally, red, white, or blue, and has a military-themed star on the hood and "Oscar Mike" badging. Otherwise you're pretty much looking at the same standard features found on the Latitude model. It starts at $21,445, and Jeep will donate $250 from each sale to charities benefiting U.S. military members.
Department of Corrections
Thanks to a last-minute snafu, we mistakenly omitted the contact info for Gale Banks Engineering from "More Air," (Jan '13). In that story we covered the installation of the company's Ram-Air Intake System on an '07 Wrangler with a 3.8L and told you how it bumped fuel mileage by 1.25 mpg and allowed the Jeep to chirp the tires from a stop. And since we've got the opportunity, here's a shot of the company's new Ram-Air Intake System for '12-up Wranglers with the 3.6L Pentastar engine.
Contact: Gale Banks Engineering, 866/602-4307, bankspower.com/ra2
Twit Watch
Reader Quote Without Story*
*As seen on Jp's Facebook page


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|California Precision Rifle Club California Precision Rifle Club Forum
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CaPRC Tactical Rimfire match announcement 8-26-12
The California Precision Rifle Club is proud to announce that our next Tactical Precision Rimfire match will be Sunday August 26th at the Angeles Ranges.
For details about the Angeles Ranges, see their website: http://www.angelesranges.com
Signups start at 7:30am and shooting should start at 8:15am when the line goes hot.
This month we will be shooting on the private "Fort Angeles" range. From the main parking lot, take the road on the left, go past the Gun/Reloading store, it is the first range on the right side of the road. Park in the dirt on the side of the road, or in the main parking lot and walk in.
Please arrive no later than 7:30am to complete your waivers, sign-in and get assigned your shooter numbers. Your shooters number is also your position on the line so please lineup accordingly. Please note that we will be in the sun all match (no overhead cover), bring fluids to drink and sunscreen, it probably will be a hot one. Also, the entire range is dirt, be sure to bring a shooting mat, moving blanket, or other ground cover if you don't want to lay in the dirt all day.
Match fee is $20 for Caprc members or $30 for non members.
We will finish by 11:30 as we have to vacate the range by noon.
Bring 100 rounds of ammo minimum, suggest 150-200 rounds as you will have time to confirm your zero.
Be prepared to shoot as close as 10yds and as far as 100yds.
Be prepared to shoot from standing, kneeling, seated, prone and other improvised positions.
Future match dates as well as general rules, guides, and suggestions can be found on the CaPRC forums: http://www.caprc.com/forums/viewtopic.php?f=13&t=3512
Previous match report is posted here: http://www.calguns.net/calgunforum/s...d.php?t=540736
This match is open to bolt action and semi-auto rimfire rifles in .22 lr caliber only.
No Hyper velocity ammo, match grade target ammo recommended.
Bipods, slings, shooting mats and rear bags are allowed and recommended.
Chamber flags are mandatory and are available from the club if needed. Observers are welcome!
Line helpers are always needed! If you are planning on attending to just watch and not shoot, please volunteer to be a line helper. Duties may include: Helping stapling and placing targets, keeping score, and spotting. Its a great way to get up and close to the action and see whats its all about.
Line helper RSVP's will be accepted anytime.
CaPRC Member RSVP's will be accepted after 12 noon on Monday August 20th.
Non-Member RSVP's will be accepted after 12 noon on Tuesday August 21th.
RSVP's posted before those times will be ignored.
Please RSVP by posting something very definite in this thread such as "I am in to shoot" or "I will be there" as we will ignore "maybe" or "if" RSVP's.
If you RSVP and later figure out that you can't come, please post that as well so we can keep the RSVP list current and move people up from the waiting list. Please RSVP as soon as possible so we can ensure we print out enough targets. Walk-ons will be accepted only if we have enough targets.
The following people have acceptably RSVP'd:
Range Officers/Line Helpers:
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