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Check Credit - The following criteria they should consider were low interest rates, application fees if any, or be sure that a secured reports issuer in toms all three credit bureaus about the application. They should consider searching to secured credit reports that had low interest rates or no application fees included. Also, the important thing to remember is all secured credit reports should be reported at all credit bureaus to approval.
Check Credit, The importance of reviewing your credit history cannot be overemphasized. A successful businessman was recently denied a loan due to his credit report. Although he was certain that he had a clean credit history, the bank informed him that he was overextended. Unfortunately, someone else's credit history and his had become merged. Such mistakes are rare, but a simple credit check could have avoided this disaster.
The key to credit repair lies with your credit history report which depends on whether or not your creditor reports your nonpayment to credit reporting agencies. In most cases, creditors are open to discussing some alternate payment plan. The creditor wants to work with you, because to push you away means they will not receive a payment at all.
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The other, more common cause of spending is rooted in childhood deprivation. Many people grew up with not enough money (or time, love, attention...). Ive heard many stories of having to shop to the best bargains as a kid, of hour-me-down clothes or small cramped houses. These children often grow up or strive to heal all these old deprivations by spending money. One woman said, Id rather die than go into a used clothing store. It puts me back right were I come from, or I dont want to go back there. The dilemma is that it is difficult, in fact impossible, to heal old deprivations by spending money, because at heart these were emotional issues. Or they couldnt heal emotion issues with physical means. It just doesnt work.
Check Credit - The realtors fees were also something we shouldnt togged. These were often negotiable, so it could help to persistently ask the realtor to take a lower cut to help facilitate the transaction.
The service offered by Experian is virtually unmatched by others. It seems that the only benefit that the other companies can offer you is that they can show you all 3-credit reports at once, including Experian, Equifax, and TransUnion. But Experian offers quality customer service as well as an easy to navigate website. The choice is yours.
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5067 N RED MAPLE Street, Irons, MI
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$ Click for current price
5 BEDROOMS | 4 (3 full, 1 half ) BATHROOMS | 3660 SQUARE FEET
50 foot frontage on all sports 92 acre Loon Lake situated on South side and overlooks the length of the lake. Home features 5 bedrooms 3.5 baths large master suite wood burning fireplace vaulted ceilings large deck at the home and at the lakefront and hot tub. There is a 3 car garage, additional 1 car garage.
Listing data of Coldwell Banker AJS-Schmidt Grand Rapids Broker from GRAR MLS is deemed reliable, but not guaranteed and is made available for personal and non-commercial use

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Tuesday's Child is Full of Physicians
(I don't know what that means either but I liked it.)
If it was Tuesday, then there was yet another appointment with a surgeon because I like my stress served like dixie cups coming out of a dispenser. This was the hernia surgeon. I went potluck on him-and by that I mean-I asked for the next available opening and ha ha-guess what? The Monday doctors called this guy: The Boss.
The what? I ask. He's the boss. Of the whole department. Oh.
Imagine that. I watched his little movie. He used the phrase 'cutting edge' so many times-I thought it was kinda funny. Tuesday was election day and P is a judge(is anyone surprised by that?)so he was seriously bummed that he was gonna miss it. I guess it'd be like missing an episode of Dallas or something. He's come this far...
I asked Marilyn and not because of her perfect penmanship and not because she was the only one that wriggled past my no visitors/who really wants to see me like that-rule in September, but because she was free and she knows all my crap. Generally speaking.
If you want charming handwriting on your notes, bring a former 5th grade teacher.
My blood pressure came in at a new low. (All heads turn toward Philip and his foolishness accusingly.) Marilyn brought a sock to knit-and Philip had made me be sure to let her know that these appointments could go forever and I betcha she made probably two stitches.
It was as fast as the last one had been torturously slow. Two people in white coats entered and I said, Oh! And here come the Residents! And ha ha on me-the female was ALREADY a doctor. I had no idea.
A moment of silence for her awesomeness.
Ya wanna know something? This physician was able to look at the whole picture. I think sometimes the dudes forget there's an actual person in there, ya know? Maybe not all the dudes, but I thought I liked my initial surgeon LOTS more than I did when it was just him and me alone in the room.
She was able to kinda like translate the info into bits I could understand because I have 5 years in massaging.I think she said it three times and I thought EUREKA. Yes I DO know what fascia is/thank you for asking.
So that was very cool.
And then everybody out and then everybody back in with The Boss and I dunno. It was a kind of a really cool session. Not half as frightening as I had imagined.
I asked The Boss: Can something so tiny hurt that much? He said: Do you have children?
Oh and I think they even had a secret doctor laugh at me. That constipation thing? They said I could take that horrendous magnesium sulfate junk? And I said, I was afraid I'd explode. (No really. I was.) And I think she thought that was so hilarious she made me repeat it.
(You think we don't laugh at people in MY jobs? You think wrong.) Oh and the answers are the following: colace, dulcolax and/or magnesium citrate.
So another test on the way. The thyroid thing this Friday and the cat scan the following Tuesday. Not scared.
Speaking of charming, I got this swell note from my pal Shari:
Who knew that the thyroid looks like an elephant, I'm a little bit smarter today thanks to you.Also, thanks for writing your blog, as you can see I'm still reading it! I can't imagine when you find time and energy to do it. You are pretty amazing.
True confessions:
I've been sleeping like a crazy person. Really. Hours and hours and hours.
My new treats are called: Kool Aid Jammers. For no good reason except I am restricted from pop so I'm insisting on having one drink of misbehavior everyday. I tried orange and now I'm on the blue raspberry. Whoopie!
We got this invitation thing to go to the Y in Berwyn and listen to some life coach type(gaaah) lady talk about Your New Life After Cancer. The only thing interesting about that is, that I was sort of waiting for things to change? I dunno. It seemed like they had to, no? And lately? I'm strong arming them into changing all by myself. POW.
(Also I get a continual sense that people(including maybe even me)are waiting for things to get back to normal? Normal is gone. YAY!)
The week ahead: SEX SEX SEX. Okay just that intimacy class coming up this week-I said hey maybe we should pick up a bottle of Courvoisier, oui?
Brace yourselves.


text:
RACE. By Michael J. Bamshad and Steve E. Olson
- Amberlynn Allen
- 3 years ago
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1 DOES RACE EXIST By Michael J. Bamshad and Steve E. Olson IF RACES ARE DEFINED AS GENETICALLY DISCRETE GROUPS, NO. BUT RESEARCHERS CAN USE SOME GENETIC INFORMATION TO GROUP INDIVIDUALS INTO CLUSTERS WITH MEDICAL RELEVANCE 78 SCIENTIFIC AMERICAN DECEMBER 2003
3 Look around on the streets of any major city, and you will see a sampling of the outward variety of humanity: skin tones ranging from milk-white to dark brown; hair textures running the gamut from fine and stick-straight to thick and wiry. People often use physical characteristics such as these along with area of geographic origin and shared culture to group themselves and others into races. But how valid is the concept of race Overview/Genetics of Race The outward signs on which most definitions of race are based such as skin color and hair texture are dictated by a handful of genes. But the other genes of two people of the same race can be very different. Conversely, two people of different races can share more genetic similarity than two individuals of the same race. Nevertheless, scientists can use genetics to sort most large populations according to their ancestral geographic origin. This approach does not work as well for populations resulting from recent mixing with other groups, however. The medical implications of racial genetic differences are still under debate. from a biological standpoint? Do physical features reliably say anything informative about a person s genetic makeup beyond indicating that the individual has genes for blue eyes or curly hair? The problem is hard in part because the implicit definition of what makes a person a member of a particular race differs from region to region across the globe. Someone classified as black in the U.S., for instance, might be considered white in Brazil and colored (a category distinguished from both black and white ) in South Africa. Yet common definitions of race do sometimes work well to divide groups according to genetically determined propensities for certain diseases. Sickle cell disease is usually found among people of largely African or Mediterranean descent, for instance, whereas cystic fibrosis is far more common among those of European ancestry. In addition, although the results have been controversial, a handful of studies have suggested that African-Americans are more likely to respond poorly to some drugs for cardiac disease than are members of other groups. Over the past few years, scientists have collected data about the genetic constitution of populations around the world in an effort to probe the link between ancestry and patterns of disease. These data are now providing answers to several highly emotional and contentious questions: Can genetic information be used to distinguish human groups having a common heritage and to assign individuals to particular ones? Do such groups correspond well to predefined descriptions now widely used to specify race? And, more practically, does dividing people by familiar racial definitions or by genetic similarities say anything useful about how members of those groups experience disease or respond to drug treatment? In general, we would answer the first question yes, the second no, and offer a qualified yes to the third. Our answers rest on several generalizations about race and genetics. Some groups do differ genetically from others, but how groups are divided depends on which genes are examined; simplistically put, you might fit into one group based on your skin-color genes but another based on a different characteristic. Many studies have demonstrated that roughly 90 percent of human genetic variation occurs within a population living on a given continent, whereas about 10 percent of the variation distinguishes continental populations. In other words, individuals from different populations are, on average, just slightly more different from one another than are individuals from the same population. Human populations are very similar, but they often can be distinguished. Classifying Humans AS A FIRST STEP to identifying links between social definitions of race and genetic heritage, scientists need a way to divide groups reliably according to their ancestry. Over the past 100,000 years or so, anatomically modern humans have migrated from Africa to other parts of the world, and members of our species have increased dramatically in number. This spread has left a distinct signature in our DNA. To determine the degree of relatedness among groups, geneticists rely on tiny variations, or polymorphisms, in the DNA specifically in the sequence of base pairs, the building blocks of DNA. Most of these polymorphisms do not occur within genes, the stretches of DNA that encode the information for making proteins (the molecules that constitute PHOTOILLUSTRATIONS BY NANCY BURSON (preceding page) 80 SCIENTIFIC AMERICAN DECEMBER 2003
4 Individuals from different populations are, on average, just slightly more different from one another than are individuals from the same population. much of our bodies and carry out the chemical reactions of life). Accordingly, these common variations are neutral, in that they do not directly affect a particular trait. Some polymorphisms do occur in genes, however; these can contribute to individual variation in traits and to genetic diseases. As scientists have sequenced the human genome (the full set of nuclear DNA), they have also identified millions of polymorphisms. The distribution of these polymorphisms across populations reflects the history of those populations and the effects of natural selection. To distinguish among groups, the ideal genetic polymorphism would be one that is present in all the members of one group and absent in the members of all other groups. But the major human groups have separated from one another too recently and have mixed too much for such differences to exist. Polymorphisms that occur at different frequencies around the world can, however, be used to sort people roughly into groups. One useful class of polymorphisms consists of the Alus, short pieces of DNA that are similar in sequence to one another. Alus replicate occasionally, and the resulting copy splices itself at random into a new position on the original chromosome or on another chromosome, usually in a location that has no effect on the functioning of nearby genes. Each insertion is a unique event. Once an Alu sequence inserts itself, it can remain in place for eons, getting passed from one person to his or her descendants. Therefore, if two people have the same Alu sequence at the same spot in their genome, they must be descended from a common ancestor who gave them that specific segment of DNA. One of us (Bamshad), working with University of Utah scientists Lynn B. Jorde, Stephen Wooding and W. Scott Watkins and with Mark A. Batzer of Louisiana State University, examined 100 different Alu polymorphisms in 565 people born in sub-saharan Africa, Asia and Europe. First we determined the presence or absence of the 100 Alus in each of the 565 people. Next we removed all the identifying labels (such as place of origin and ethnic group) from the data and sorted the people into groups using only their genetic information. Our analysis yielded four different THE AUTHORS MICHAEL J. BAMSHAD and STEVE E. OLSON have come to the subject of human genetic variation from different directions. Bamshad, a geneticist at the University of Utah School of Medicine, studies the genetics of populations to better understand human history and the origins of disease. Olson, a science writer who lives outside Washington, D.C., is the author of Mapping Human History: Genes, Race, and Our Common Origins, which was nominated for the 2002 National Book Award in nonfiction. They met during the writing of Mapping Human History and have been working together ever since to explore and explain patterns of human genetic variation worldwide. groups. When we added the labels back to see whether each individual s group assignment correlated to common, predefined labels for race or ethnicity, we saw that two of the groups consisted only of individuals from sub-saharan Africa, with one of those two made up almost entirely of Mbuti Pygmies. The other two groups consisted only of individuals from Europe and East Asia, respectively. We found that we needed 60 Alu polymorphisms to assign individuals to their continent of origin with 90 percent accuracy. To achieve nearly 100 percent accuracy, however, we needed to use about 100 Alus. Other studies have produced comparable results. Noah A. Rosenberg and Jonathan K. Pritchard, geneticists formerly in the laboratory of Marcus W. Feldman of Stanford University, assayed approximately 375 polymorphisms called short tandem repeats in more than 1,000 people from 52 ethnic groups in Africa, Asia, Europe and the Americas. By lookwww.sciam.com SCIENTIFIC AMERICAN 81
5 HUMAN GENETIC DIVERSITY RESEARCHERS OFTEN USE SHORT PIECES of DNA called Alu polymorphisms to determine whether various populations are related to one another. Alus have no known function, yet they copy and insert themselves at random throughout a person s genome. Because previously inserted Alus do not excise themselves, Alu patterns can be used as yardsticks to estimate how close two people and, on average, two populations are genetically. For example, an Alu polymorphism on chromosome 1 occurs in roughly 95 percent of sub-saharan Africans who have been sampled, 75 percent of Europeans and northern Africans, and 60 percent of Asians, whereas a different Alu polymorphism on chromosome 7 is carried by approximately 5 percent of sub-saharan Africans, 50 percent of Europeans and northern Africans, and 50 percent of Asians. Some individuals carry both polymorphisms. No single polymorphism can, by itself, distinguish all the members of one major human group from all the members of another group, but by analyzing hundreds of these polymorphisms, scientists can group individuals sampled from different locations on the basis of their genetic profiles. M.J.B. and S.E.O. EUROPEANS AND NORTHERN AFRICANS 75% Chromosome 1 Alu 50% Chromosome 7 Alu (25% Both) ASIANS 60% Chromosome 1 Alu 50% Chromosome 7 Alu (10% Both) SUB-SAHARAN AFRICANS 95% Chromosome 1 Alu 5% Chromosome 7 Alu Chromosome 1 Alu Chromosome 7 Alu Both Alus ing at the varying frequencies of these polymorphisms, they were able to distinguish five different groups of people whose ancestors were typically isolated by oceans, deserts or mountains: sub-saharan Africans; Europeans and Asians west of the Himalayas; East Asians; inhabitants of New Guinea and Melanesia; and Native Americans. They were also able to identify subgroups within each region that usually corresponded with each member s self-reported ethnicity. The results of these studies indicate that genetic analyses can distinguish groups of people according to their geographic origin. But caution is warranted. The groups easiest to resolve were those that were widely separated from one another geographically. Such samples maximize the genetic variation among groups. When Bamshad and his co-workers used their 100 Alu polymorphisms to try to classify a sample of individuals from southern India into a separate group, the Indians instead had more in common with either Europeans or Asians. In other words, because India has been subject to many genetic influences from Europe and Asia, people on the subcontinent did not group into a unique cluster. We concluded that many hundreds or perhaps thousands of polymorphisms might have to be examined to distinguish between groups whose ancestors have historically interbred with multiple populations. NADIA STRASSER 82 SCIENTIFIC AMERICAN DECEMBER 2003
6 Genetic analyses can distinguish groups of people according to their geographic origin. But caution is warranted. The Human Race GIVEN THAT PEOPLE can be sorted broadly into groups using genetic data, do common notions of race correspond to underlying genetic differences among populations? In some cases they do, but often they do not. For instance, skin color or facial features traits influenced by natural selection are routinely used to divide people into races. But groups with similar physical characteristics as a result of selection can be quite different genetically. Individuals from sub-saharan Africa and Australian Aborigines might have similar skin pigmentation (because of adapting to strong sun), but genetically they are quite dissimilar. In contrast, two groups that are genetically similar to each other might be exposed to different selective forces. In this case, natural selection can exaggerate some of the differences between groups, making them appear more dissimilar on the surface than they are underneath. Because traits such as skin color have been strongly affected by natural selection, they do not necessarily reflect the population processes that have shaped the distribution of neutral polymorphisms such as Alus or short tandem repeats. Therefore, traits or polymorphisms affected by natural selection may be poor predictors of group membership and may imply genetic relatedness where, in fact, little exists. Another example of how difficult it is to categorize people involves populations in the U.S. Most people who describe themselves as African-American have relatively recent ancestors from West Africa, and West Africans generally have polymorphism frequencies that can be distinguished from those of Europeans, Asians and Native Americans. The fraction of gene variations that African-Americans share with West Africans, however, is far from uniform, because over the centuries African-Americans have mixed extensively with groups originating from elsewhere in Africa and beyond. Over the past several years, Mark D. Shriver of Pennsylvania State University and Rick A. Kittles of Howard University have defined a set of polymorphisms that they have used to estimate the fraction of a person s genes originating from each continental region. They found that the West African contribution to the genes of individual African-Americans averages about 80 percent, although it ranges from 20 to 100 percent. Mixing of groups is also apparent in many individuals who believe they have only European ancestors. According to Shriver s analyses, approximately 30 percent of Americans who consider themselves white have less than 90 percent European ancestry. Thus, self-reported ancestry is not necessarily a good predictor of the genetic composition of a large number of Americans. Accordingly, common notions of race do not always reflect a person s genetic background. Membership Has Its Privileges UNDERSTANDING the relation between race and genetic variation has important practical implications. Several of the polymorphisms that differ in frequency from group to group have specific effects on health. The mutations responsible for sickle cell disease and some cases of cystic fibrosis, for instance, result from genetic changes that appear to have risen in frequency because they were protective against diseases prevalent in Africa and Europe, respectively. People who inherit one copy of the sickle cell polymorphism show some resistance to malaria; those with one copy of the cystic fibrosis trait may be less prone to the dehydration resulting from cholera. The symptoms of these diseases arise only in the unfortunate individuals who inherit two copies of the mutations. Genetic variation also plays a role in individual susceptibility to one of the worst scourges of our age: AIDS. Some people have a small deletion in both their copies of a gene that encodes a particular cell-surface receptor called chemokine receptor 5 (CCR5). As a result, these indiwww.sciam.com SCIENTIFIC AMERICAN 83
7 viduals fail to produce CCR5 receptors on the surface of their cells. Most strains of HIV-1, the virus that causes AIDS, bind to the CCR5 receptor to gain entry to cells, so people who lack CCR5 receptors are resistant to HIV-1 infection. This polymorphism in the CCR5 receptor gene is found almost exclusively in groups from northeastern Europe. Several polymorphisms in CCR5 do not prevent infection but instead influence the rate at which HIV-1 infection leads to AIDS and death. Some of these polymorphisms have similar effects in different populations; others only alter the speed of disease progression in selected groups. One polymorphism, for example, is associated with delayed disease progression in European-Americans but accelerated disease in African-Americans. Researchers can only study such population-specific effects and use that knowledge to direct therapy if they can sort people into groups. In these examples and others like them a polymorphism has a relatively large effect in a given disease. If genetic screening were inexpensive and efficient, all individuals could be screened for all such disease-related gene variants. But genetic testing remains costly. Perhaps more significantly, genetic screening raises concerns about privacy and consent: some people might not want to know about genetic factors that could increase their risk of developing a particular disease. Until these issues are resolved further, self-reported ancestry will continue to be a potentially useful diagnostic tool for physicians. Ancestry may also be relevant for some diseases that are widespread in particular populations. Most common diseases, such as hypertension and diabetes, About the Photoillustrations NEW YORK ARTIST Nancy Burson used her invention, called the Human Race Machine, to generate the series of composite photographs that appears on page 79 (two also appear elsewhere in this article). The machine takes a photograph of an individual in this case, a white woman and adds and subtracts various outward features of racial identity to show what a person might look like if he or she were a member of another race. Burson says she seeks to use her work to underscore the commonality of humanity. And indeed, outward features often say little about the bulk of a person s genetic makeup. The Human Race Machine was one of the most popular attractions at the Millennium Dome in London, where it drew hundreds of thousands of people. More about the artist and her work can be found on her Web site, are the cumulative results of polymorphisms in several genes, each of which has a small influence on its own. Recent research suggests that polymorphisms that have a particular effect in one group may have a different effect in another group. This kind of complexity would make it much more difficult to use detected polymorphisms as a guide to therapy. Until further studies are done on the genetic and environmental contributions to complex diseases, physicians may have to rely on information about an individual s ancestry to know how best to treat some diseases. Race and Medicine BUT THE IMPORTANCE of group membership as it relates to health care has been especially controversial in recent years. Last January the U.S. Food and Drug Administration issued guidelines advocating the collection of race and ethnicity data in all clinical trials. Some investigators contend that the differences between groups are so small and the historical abuses associated with categorizing people by race so extreme that group membership should play little if any role in genetic and medical studies. They assert that the FDA should abandon its recommendation and instead ask researchers conducting clinical trials to collect genomic data on each individual. Others suggest that only by using group membership, including common definitions of race based on skin color, can we understand how genetic and environmental differences among groups contribute to disease. This debate will be settled only by further research on the validity of race as a scientific variable. A set of articles in the March 20 issue of the New England Journal of Medicine debated both sides of the medical implications of race. The authors of one article Richard S. Cooper of the Loyola Stritch School of Medicine, Jay S. Kaufman of the University of North Carolina at Chapel Hill and Ryk Ward of the University of Oxford argued that race is not an adequate criterion for physicians to use in choosing a particular drug for a given patient. They pointed out two findings of racial differences that are both COURTESY OF NANCY BURSON 84 SCIENTIFIC AMERICAN DECEMBER 2003
8 Tracing Human Origins COUNTING THE NUMBER of DNA units called short tandem repeats on chromosomes can allow scientists to group individuals according to probable ancestry. One such repeat, AAAG, occurs between two and seven times in people with African heritage but between five and eight times in those whose ancestors came from Europe or the Middle East. (Every person inherits one set of repeats from their mother and one from their father.) Accordingly, someone who carries two and three repeats is likely to have African heritage, whereas someone with six and eight repeats probably has ancestors from Europe or the Middle East. People with between five and seven repeats occur in both populations, however, making these individuals more difficult to classify using only this particular repeat. M.J.B. and S.E.O. Unit of repeat AAAGAAAG AAAGAAAGAAAGAAAGAAAGAAAG AAAGAAAGAAAG AAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAG DNA Chromosome inherited from mother Chromosome inherited from father Carries 2 and 3 repeats: Likely to have African heritage Relative Number of Carriers People from Europe/Middle East People from Africa Number of Repeats on a Chromosome Carries 6 and 8 repeats: Likely to have ancestors from Europe or the Middle East NADIA STRASSER MORE TO EXPLORE now considered questionable: that a combination of certain blood vessel dilating drugs was more effective in treating heart failure in people of African ancestry and that specific enzyme inhibitors (angiotensin converting enzyme, or ACE, inhibitors) have little efficacy in such individuals. In the second article, a group led by Neil Risch of Stanford University countered that racial or ethnic groups can differ from one another genetically and that the differences can have medical importance. They cited a study showing that the rate of complications from type 2 diabetes varies according to race, even after adjusting for such factors as disparities in education and income. The intensity of these arguments reflects both scientific and social factors. Many biomedical studies have not rigorously defined group membership, relying instead on inferred relationships based on racial categories. The dispute over the importance of group membership also illustrates how strongly the perception of race is shaped by different social and political perspectives. In cases where membership in a geographically or culturally defined group has been correlated with health-related genetic traits, knowing something about an individual s group membership could be important for a physician. And to the extent that human groups live in different environments or have different experiences that affect health, group membership could also reflect nongenetic factors that are medically relevant. Regardless of the medical implications of the genetics of race, the research findings are inherently exciting. For hundreds of years, people have wondered where various human groups came from and how those groups are related to one another. They have speculated about why human populations have different physical appearances and about whether the biological differences between groups are more than skin deep. New genetic data and new methods of analysis are finally allowing us to approach these questions. The result will be a much deeper understanding of both our biological nature and our human interconnectedness. Mapping Human History: Genes, Race, and Our Common Origins. Steve Olson. Mariner Books, Human Population Genetic Structure and Inference of Group Membership. Michael J. Bamshad et al. in American Journal of Human Genetics, Vol. 72, No. 3, pages ; March The Importance of Race and Ethnic Background in Biomedical Research and Clinical Practice. Esteban González Burchard et al. in New England Journal of Medicine, Vol. 348, No. 12, pages ; March 20, Race and Genomics. Richard S. Cooper, Jay S. Kaufman and Ryk Ward in New England Journal of Medicine, Vol. 348, No. 12, pages ; March 20, SCIENTIFIC AMERICAN 85
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Fears of recession have given way to fears of inflation. The odds of a recession in 2008 have declined from earlier this year judging by the incoming economic data, the upward revisions to Wall Street economists' GDP estimates and, more colorfully, by the odds reflected in bets placed on the online betting site Intrade, where the odds of recession have fallen back to a normal level of 30-35% from 70-75%.
To see the rest of this article, please click on the link below:


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Something unusual has happened with Mercedes luxurious SUV which gets a different name and now under the new banner planning outside. Spy shots unveil to is 2018 Mercedes-Benz GLE model in the testing stage, but curious eyes can't fully to see the new design because hide cover the whole body. Earlier has been a plan to release in 2016 as an up-to-date version. In addition, changing the name delivers to looking forward to additional one year, and GLE can introduction like an all-new model. Does it effects on sale? Any delay of the model in a situation where it appears the new Audi Q7 can lead to a drop in revenue in future. Important changes are related to design and new interior; on the other hand, the power-plant range will remain unchanged. In the next pair paragraphs, we take to to explain novelties and what should you expect.
The exterior design you will not identify on the front fascia, and manufacturers can change size and shape of elements. First of all, the hood is taller and reshaped, but possibly with a smooth surface. Also, air dam can get the bigger opening for outstanding circulation capacity. Further, top grille keeps with the same shape and probably something larger. That is not absolutely all, the new design of headlights and better intensity of lighting thanks to the LED technology. Other on the rear end, you can observe round taillights, ornamental facts, and much more. Looking at the side you see same design philosophy, but with various arches around wheels and glass areas above doors. For additional information about 2018 Mercedes-Benz GLE external, you must wait for the world premiere.
Mercedes-Benz has well-known for the comfortable interior which is enriched luxurious products and hi-tech devices. This time, new 2018 Mercedes-Benz GLE should get creativity by E-Class cabin. What these just mean? We assume renovated middle console which takes all-new instrument cluster. Moreover, the carmaker can mount new infotainment system with tools, applications and still another shortcut. If you look tightly HVAC vents have a new design, and above instrument section, you can observe overhang. Chairs have covered with soft leather and provide room enough between lines for knees. On the same way, baggage place comes larger than before and can satisfy all your needs.
The power-plant range includes tried fuel, diesel and cross product with slightly higher power. Certainly, they need to in the future to develop new energy plants, but let us see what will happen. For 2018 Mercedes-Benz GLE iteration you can choose fuel 3.5-liter V6 engine that produces 302 horsepower and turbocharged 3.0-liter V6 with 330 horsepower. If you want financial alternative then 2.1-liter turbodiesel engine right choice. It generates around 201 horsepower and 369 lb-ft of torque. For folks who like electrification of the drive, cross appears like as a reasonable option. The combination of a 3.0-liter gasoline engine with an electric motor gives 436 horsepower. Great towing volume, all driving wheels, and automatic transmission completes these specs.
Price will perhaps not drastic develop since changes are at the level of updates. Direct competitors are beside above-mentioned Audi Q7 and BMW X5.


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Sometimes you are automatically added by someone to groups you don't like. The main of his/her purpose is to introduce their products, their website to sell their goods or even spam... Therefore, is there way to get out of that group, let's find out the answer in our article.
Read More:Develop a smooth Facebook Romance
You Needs to Know About Social Graphs
26 Ways to Engage Your Fans on Facebook
Step 1:Firstly, click more in the group section on the left side of your facebook page
Step 2:
A list of green will appear. Secondly,choose group you want to leave from that list
Step 3:Thirdly click at the top right corner of your page. Then select Leave Group from the dropdown menu.
Step 4:
Finally, a box appear and you only click leave group, if you don't want anyone add you to that group again click tick to "prevent other member from re-adding you after you have left


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Thursday, 9 August 2007
On reading
To begin with, it is money, or lack thereof. Not just me (although I think I have always lived well on the 'wrong' side of the official poverty line; even when I had 'proper' jobs). I always find cash for books. But I do not buy anything until I have read it and know that I want to read it again. I cannot afford the luxury of buying books on the off-chance. That has always meant trips to the library armed with sheaves of request slips; knowing that I was getting a good read and introducing off beat titles that others might chance upon.
This year, however, one of the local authorities whose libraries I use has introduced swingeing cuts to their library budget (30% was the figure I was given). They are planning equally vicious cuts next year. This has resulted in rapidly emptying shelves where old stock is not replaced and a huge reduction in choice. It has also meant that members of the public can no longer request titles not already held in stock.
They are buying new books, but from a recent trawl through their idiotic online catalogue (that is another bone of contention – why do they list books on their catalogue that they do not hold in stock?), these are not books that interest me. I do realize, of course, the library system is not there solely for my benefit, but I can now no longer read new books in the hope of discovering a new author.
And the other local authority (the one in whose boundaries I actually live) is equally unhelpful. The main library is over thirty miles away, but we do have a tiny branch in the village. It is about the size of our living room. The problem is, it is not linked to the main system. I cannot, therefore, browse their online catalogue and order a book. I have to go to my branch, give the details to the librarian who then puts in a request on a slip of paper, and wait. I also have to pay up front. I don't mind that from a cost point of view, but it is a real hassle if they don't send the book as you cannot get refunds. You have to order another book. And their stock is not up to much.
Another reason I am re-reading is that after a long period of trying to discover new authors whose work I enjoy, I have given up. Now, I am happy to believe this is just me. I'm getting on a bit; probably fossilising. Nothing is as good as it was in my young day. Oh no. On the other hand, I do sometimes wonder what has happened to writing recently.
I suppose I could have a go at agents and publishers. They, after all, are the portal through which works must pass before making it into print on a commercial scale (that is, scale enough for the writer to earn something more than it costs to keep their printer filled with ink). And I know there are writers out there producing stuff that is far superior to a great deal of the crap that actually gets put on the shelves of book shops.
When I say crap, I am not making a judgement based on subject matter. Tastes are infinitely varied. When I say crap, I mean two things. The first is yet another book without merit or originality that is riding the tail end of a bandwagon from which agents and publishers hope to squeeze a bit more dosh. The second, and much worse type of crap, are all those books that are badly written.
"Is that not just as subjective as taste in content or style?" I hear you ask. To which I would reply with an emphatic and resounding, "NO!"
There are certain types of book and certain styles of writing I do not enjoy. The things I love, I know, are not liked by others. But there is, I would contend, a difference between personal taste and knowing whether or not something is badly written. This is mostly to do with syntax, but it is also about plotting and character development – all those things you will find in creative writing courses and in the countless books produced by editors, agents, and writers on how to write books that will get published. All the rules and pointers that are regularly and depressingly ignored in many of the books that make it into print.
I spent several hours in a bookshop yesterday, taking book after book from the shelves in the 'New Titles' section. And book after book went back onto the shelves because I could not find one that did not have some basic, syntactical error; or that did not read like something an earnest fifteen year old had written with a thesaurus to hand and a burning desire to impress.
Perhaps I am too sensitive about these things, but it seems to me that if I am paying out seven or eight quid for a book, I have a right to expect a certain level of basic literacy, something that is reasonably well constructed, with an absence of too many typos.
So I go back to books I know are well written; to authors I know who care about the language and have learned to craft it both appropriately to their story and with respect for a medium that can do so much to please and enlighten others.
I am not sure there is any point to this little grumble other than to explain to myself (and anyone else who cares to listen) why I am re-reading so much old stuff at the moment. Besides, revisiting old friends, sometimes after years of absence is great fun. I have started on a chronological read of Dickens and have promised myself the same with Virginia Woolf. I have been rediscovering the joys of Albert Campion and Sherlock Holmes; exercising my flabby intellect with the work of Langdon Jones and Barrington J Bayley; and experiencing yet again the awe I have always felt with what Samuel Beckett does with language. I have been smiling quietly at the antics of William; rediscovering some of my metaphysical roots in the books of Mike Moorcock; and immersing myself in the tricky mists of Celtic myth.
New authors? Who needs 'em.
7 comments:
- B.E. Sanderson said...
That stinks about your library. I'm not much of a library gal these days, but I take my daughter every day and if we couldn't request books, she'd be lost.
Sorry I haven't been here sooner. Welcome to the Novel Race. =oD
- 10 August 2007 at 13:23
- Graeme K Talboys said...
Thanks. I don't see any sense in such cuts as they are self-fulfilling. Fewer books so people use the library less, so the library needs fewer books. Madness.
- 10 August 2007 at 15:15
- Papoosue said...
Hi Graeme. This also seems to be happening where I am in Fife. If they haven't got it, then that's that. Extremely irritating to say the least. I have no spare cash to buy any book that takes my fancy and it just seems to me that the less money you have, the less is available to you in all areas. I could go on but I won't.....!
- 11 August 2007 at 07:46
- Papoosue said...
Yes. And another thing that really annoys me is that in bookshops/supermarkets etc we get what we are given, not what we want. There is no choice unless we go looking for it. GRRRRRRR
- 11 August 2007 at 09:21
- Graeme K Talboys said...
And without being able to browse physical books - enjoy the sensation of handling them and seeing how well produced they are as well whether the content is appealing - we lose the chance discoveries and the sensual pleasure of books.
- 11 August 2007 at 15:41
- Papoosue said...
- 11 August 2007 at 20:18
- Kat said...
I couldn't help nodding emphatically to myself whilst reading your post. I gave up on my local library when they took out all my old favourite classics, to be replaced by cardboard writing, that leaves you as hungry for the written word at the end, as you had at the begining of reading them.
I'm envious of my younger self for all the beauties I read and, like you, started to re-read them all a few years ago. What joy!
- 14 September 2007 at 23:29


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In today's world we are expected to meet certain criteria or risk being labeled an odd duck. There is little in the way of risk taking that is acceptable compared with a century ago when risk taking was an everyday event. Some of risk taking is acceptable in the Military and the sports world but not within most other areas of society. It is something that has been regulated to conform everyone into the good-neighbor syndrome. There is nothing wrong with being a good-neighbor, I want all my neighbors to be wonderful and nice people, but there is something missing in people's lives today.
Amusement parks have exploded in popularity around the world willing to fill in the need for excitement. The adrenalin rush we experience on a roller coaster fills a need we don't realize within our minds.
Susan B. Anthony once wrote, "Cautious, careful people, always casting about to preserve their reputation and social standing, never can bring about a reform. Those who are really in earnest must be willing to be anything or nothing in the world's estimation."
Risking everything isn't something most folks are willing to do, most folk's wish a comfortable life, going willingly into a regulated life with little risk. Is that what God wants? Is the Christian message Jesus gave to the world, "Go ye therefore into the world, and make as many as you can comfortable." We must be willing to be
Just like the first Christians, who were willing to risk everything, including their lives. So we should have the same convictions, even within our daily humdrum lives. How, you ask? Read your bible again for the very first time, believe what you read and take it into your heart. It will change your world unlike anything you have ever experienced. It will take you on a journey out of the comfort of this world and into the Kingdom of God.


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Summer Solstice Sauce
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Summer Solstice Sauce
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- In a blender container combine all ingredients. Cover and blend until smooth. Use sauce cold, or cook until bubbly and slightly thickened for a grilling glaze or dipping sauce. Makes 1/2 cup (eight, 1-tablespoon servings).
Food exchanges:
- 1 fruit.
From the Test Kitchen
Prepare sauce; cover and chill up to 3 days.
Nutrition Facts (Summer Solstice Sauce)
- Per serving:
- 57 kcal ,
- 2 mg sodium ,
- 15 g carb.


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Designing you own website can be an exciting prospect and an overwhelming one! Apply the advice of this article to prepare yourself for both handling the rigors and reaping the benefits.
Avoid using clashing, loud colors when designing your website. It is important for the text to be legible when set on the background color you have chosen. Dark text on light backgrounds are typically easier on the eyes than the other way around. If you need help determining weak points of your website, show your current version to a friend for feedback.
Make sure your site passes the NoScript test. You can add this extension to Firefox, and then use it against your website. There are some elements (e.g. ordering products) that will not work if there is no script. For this reason, if your website is blank and has no scripts, it will not work.
In order for your website to be successful, it must work properly regardless of the browser that is used. You should therefore make certain that all of your web pages are thoroughly tested on a variety of browsers. If something works in Chrome it might not work in Firefox, for example. Prior to formally launching your site, verify that it displays correctly in each of these popular browsers.
Don't have an abundance of graphics on your site. While they're essential to creating a cohesive and professional site, too many can make it look cluttered. Graphics are not for decoration or ornamentation. Instead, they are to help you improve the overall appeal and usability of your site. Having the right amount of graphics that don't clutter the design can improve the site's usability, too.
Before publishing your website, check it over carefully for any broken links. An error page after clicking a link is very frustrating for visitors to your page. You can manually check links or use a program that will find broken links for you.
It is very important that you double-check your website for broken links before you publish the pages. The worst experience for a visitor is to have interest in learning more only to click the dreaded dead end link. If you have very few links, you can check them manually. If many links, try using a link-checking program that can do the work for you quickly.
If you want your site to reach search engines, ditch frames. While many people like frames, information tends to not be easily seen via search engines. If search engines are unable to see some of the key information presented by your site, your ranking is bound to suffer. If you don't do what's necessary to make sure that your site is not ranked very high, people will not find your site very easily.
Pay attention to the background of your website. Backgrounds with moving GIF views can be great, but can make text hard to read as well. Pick a background that meshes with your site, not against it, and your viewers will have a much easier time understanding what you want to say.
Your user's needs should be your top priority. The web designer must know what the readers are looking for at all times. This includes the ease of interaction, level of usability, accessibility, and experience of the user. These are essential elements you must keep in mind. Try to see things from your visitor's perspective when you design.
Take the time to carefully think about the content you use on your website to make sure it's interesting. While the look of the design is important, the content is what keeps visitors returning to your site. Visitors will return again and again when they find valuable, useful information.
Any links you place on your site should have text content. Links with content should be visible enough to show the viewer what they're clicking. If you have links that don't specify where it takes you, then someone could mistakenly click it by using a keyboard shortcut.
Make sure that all the files on your website are small in size. You need these small file sizes regardless of the overall design of your site. The size of the files making up your website is the direct cause of your site's load times. Maximizing the loading speed of your website is always better. Even though broadband is common these days, there are still people stuck on 56K connections. Perform tests on your website to make sure that it loads fast, even when a dial-up connection is used.
Selecting a professional looking font is an important web design consideration. People judge your sites professionalism by the fonts you use. Don't use silly fonts, especially Comic Sans, or rare fonts that most people won't have installed. Your style should specify a default font in case a user doesn't have your preferred font. This can make your website look a lot worse.
Internet Explorer
Learning about design on the web is much easier as you practice. Start by creating simple pages you don't even publish to the web, just so you can see how the basics work. It's important to practice to make sure you know the ropes of web design.
Make sure you design your website with older Internet Explorer versions in mind. Although many people loathe Internet Explorer, many people surfing the Internet do it on older versions of this web browser. They don't render many elements in compliance with web standards, so workarounds are required. Specifically, read about the "box model bug" that plagued IE for years.
Know what you are getting for your money when selecting a hosting service. You will need to know the following: bandwidth, disk space, CPU usage, and any other items that are part of the package price. Know what you'll end up with, if you decide to go forward with it.
Don't accidentally place links on your site that lead to nowhere. Links with content are easier to view for your visitors and help them know exactly what they will be clicking on. If you have links that don't specify where it takes you, then someone could mistakenly click it by using a keyboard shortcut.
Most people have heard of Photoshop and know that it's a useful tool in web design. Dreamweaver is less popular but is easier to master and is filled with useful tools designed for webmasters.
Conditional loading and independent CSS pages are important when you design your website. The application of these two techniques make website testing and maintenance both less time-consuming in the future. All sites require maintenance from time to time and making that easier will save you time.
Use a layout for your site that you can work with and that is basic so that you understand the fundamentals of web design first. Starting out simple and then building your skills into tackling more complex designs is a good strategy as you improve.
Begin by creating smaller websites that allow you to gauge your strengths and weaknesses, and how to improve upon both. You want to start off with maybe a couple of pages that are basic with just information and text, and see how you feel from there.
If you use FileZilla, be certain that your username, proper port and domain are all programmed into its quick menu settings. That way, the next time you log back into your server, you just need to go to the menu and choose personalized settings. This can save you a large amount of time.
Everyone has heard about Photoshop, and they know that they have to learn it in order to become successful with website development. However, many are not as familiar with Dreamweaver software and its features. It might be worth looking into this application to find out how it can benefit you.
You always want to make the security of the website your top priority. Any personal information given on your site, such as PayPal accounts and credit card numbers, will be more secure if you give your site an SSL certificate. Look at particular web hosts to see what security options they offer in the package you have.
Website design requires proper research. Research your niche and target audience. Think about how best to design your site to reach your target market. This is an efficient way to look at things.
Link your logo to your home web page. It is common these days for sites to have a logo or image that visitors can click on to return to the home page. Users may be frustrated if they cannot easily find a way back to the home page. You will find that a clickable logo will have a positive impact on your visitor's stay on your site.
Remember that you do not have to design the entire website all by yourself. Creating a comprehensive website will require knowledge in design, programming, interface, content and SEO. You should not feel ashamed to ask for help. If there are areas that are unfamiliar to you, consider hiring a professional service to help you.
Learn how to utilize "white space" in your website. This is the blank space on web pages. Visibility is key when it comes to site design and browsing the web, so you don't want to clutter the screen. This will help customers read what you want to get across to them more quickly and keep their interest.
When you're using the file server FileZilla, be sure to quick program the menu settings with the correct port, your username, and your domain. This way, when you log back on to the server, all you need to do is select your personalized settings from the menu. You will save a lot of valuable time by doing this.
If you want to target people around your area with a website, think about getting a top level domain with a country code. This will ensure the domain name in that specific area of the country. CCTLDs are great for directing visitors from different regions to your website, especially when they might not find it otherwise.
Site Map
Draw some simple illustrations of how you'd like your website to look. Show others your design concepts and get their advice. Having an extra pair of eyes can help point out things you may have not have noticed about your design.
Make use of a site map for your website. A site map facilitates two different goals. They allow anyone who visits a website to get a quick overview. They're able to find what they're searching for and see what your site offers just by using the map. Secondly, it is a good tool for SEO, or search engine optimization. It easier for the search engines to find and "crawl" your site.
A great place to get a domain name for the website you want to design is through domain auctions. SEDO and similar domain auctions can be a big help to your website by letting you purchase already-established domain names. It may be a little pricey, but a great domain name is worth its weight in gold.
Look for unusual sources of inspiration when designing your website. Television programs, artistic exhibits, even commercials are good sources of inspiration. Be watchful! Keeping an open eye on the world will help you find the inspirations you need to always improve your site.
If your website is for commercial purposes, you should avoid using a free web host. You never want your business site to be bombarded with advertisements from other companies, as this takes away from the chief focus of what your site should be, selling your own products and services. Use a paid service for your hosting instead.
Design your website using neutral background colors. Avoid textured backgrounds because they can overwhelm the site and make it look amateur. Use a background that is white or some other neutral hue. Neutral colored backgrounds are said to be the easiest to read.
Be sure your site has a little human personality in it. Add in customer reviews, images of your company, and quotes from the media. These touches give some personality to your site. They can also build up how much expertise you have in your visitor's eyes, which is crucial if you want them to become part of a loyal base of customers.
Developing your web page design skills is a great way to improve your website's visibility and get in touch with your target customers. Think of designing your website as a part of your marketing campaign. Try using these tips to succeed.
When you hiring a professional for designing your site, always ask for references. If they don't have references, it's probably best to avoid them.


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HHMI is committed to the development of future scientists who come from all backgrounds and who are provided opportunities to actively learn in an inclusive environment.
For Individuals
Exceptional Research Opportunities Program (EXROP) ›
Mentored undergraduate research experiences in top-tier laboratories.
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Fellowships supporting research training of outstanding international predoctoral students.
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Fellowships supporting research training for medical, dental, and veterinary students.
For Institutions
Grants to Colleges and Universities ›
HHMI faciliates synergy among its consellation of Professors and Institutional grantees.
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HHMI provides grants to four-year colleges and universities to increase institutional capacity for inclusion of students from all backgrounds in science.
Science Education Alliance ›
Engaging undergraduates in the sciences through participation in authentic research courses.
Developing Scientists
HHMI supports talented scientists and educators to advance biomedical research and train the next generation of scientific leaders. Our work is shaped by three core values:
The advancement of science depends on the development of scientific thinking skills and values in every citizen, including students who will become scientists.Explore our strategies »
The future of science depends on students at all stages learning the process of science by engaging in discovery-based experiences and scientific research.Explore our strategies »
Scientific excellence depends on the development of scientific leaders who come from all backgrounds and who are nurtured by an inclusive environment.Explore our strategies »


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People have high expectations when it comes to buying vehicles. Here at Depot Auto Sales we strive to not only meet those expectations, but we look to exceed those expectations in every way. Depot Auto Sales is widely recognized for reliability, value and customer satisfaction in both sales and service.
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The Mediterranean Diet has probably focused more attention on Greek cuisine than ever before. And Greek restaurants are becoming much more popular. If you haven't ventured into a Greek restaurant yet, summer is an especially good time.
Mediterranean people love to eat. The sunny climate allows for many social gatherings where food is served. Greek cuisine has been influenced by every culture who battled for, conquered, traded and immigrated there. Many who inhabit Greece and the Mediterranean region are a mix of religions, nationalities and races. Influences include the past Ottoman Empire, Southern Italy, North Africa and the Middle East.
Mediterranean cuisine offers a great deal in the way of fruits, vegetables, whole grains, pita, pasta, olive oil, cheese, milk, eggs, fish and red wine. Less on red meat and processed foods. People of that area have been observed to have less incidences of heart disease and certain cancers, and this has been attributed to their cuisine. And that is also the basis of the currently popular Mediterranean Diet; although you certainly don't need to be dieting to enjoy the food.
Still, if you are basically health conscious and looking for some variety in dining out, Greek restaurants will definitely accomodate many of those desires.
A typical Greek Restaurant offers a wide range of vegetarian style dishes as well as seafood and chicken and of course lamb. You might enjoy a baked vegetarian moussaka with eggplant, parmesan, riccota cheese and zucchini layered, topped with tomato sauce. Other great healthful dishes include Greek Skillet Snapper or Greek Lemon Chicken. There are many lamb dishes offered too, of course. Be mindful, though, that lamb, like any red meat, should be eaten sparingly in accord with many modern health advisories. Mediterranean herbs and spices and traditional ingredients make for a very flavorful cuisine regardless of meat content. Greek Rose wine is wonderful too.
Wild marjoram grows in the mountains in Greece and is often used to flavor meat dishes. The herb is much sharper in flavor than domestic marjorams or oreganos. In Spain it was used to brew fine ales.
Here is a recipe for a Greek salad dressing with marjoram (rigani) to enjoy with fresh greens.
-1/2 cup virgin cold pressed olive oil
-Juice of one lemon (pierce with a fork and heat for a few seconds in a microwave to extract the most juice.)
-1/2 teaspoon of wild marjoram (rigani)
-1 teaspoon minced fresh mint
-1 tablespoon chopped onion
-1 tablespoon parley or cilantro
-1 teaspoon fresh cinnamon basil minced
1/2 teaspoon lemon thyme
Combine all ingredients and chill for a few hours before serving. Great on dinner salads.
Don't forget the desserts! Baklava, Kataifi, Amydgalopita....
That's pronounces bahk-lah-VAH, kah-tah-EE-fee, ah-mag-dah-lo-PETA.
Find Greek restaurants in your area at BestPlacetoEat.com
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