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–° –Я—А–∞–Ј–і–љ–Є–Ї–Њ–Љ –Т–µ—Б–љ—Л –Т–∞—Б, –Ф—А—Г–Ј—М—П!–Р–≤—В–Њ—А: admin // –†—Г–±—А–Є–Ї–Є: Uncategorized
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–Т –њ—А–µ–Ї—А–∞—Б–љ—Л–є, —П—А–Ї–Є–є, –Љ–∞–є—Б–Ї–Є–є –і–µ–љ—М!
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–Я—Г—Б—В—М –±—Г–і–µ—В –ґ–Є–Ј–љ—М –њ—А–µ–Ї—А–∞—Б–љ–∞ –≤–∞—И–∞,
–Ш –і–µ—В–Є —Б—З–∞—Б—В–ї–Є–≤—Л –≤—Б–µ–≥–і–∞,
–Я—Г—Б—В—М –і–Њ–Љ –≤–∞—И –±—Г–і–µ—В –њ–Њ–ї–љ–Њ–є —З–∞—И–µ–є!
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–Ъ —Б–њ–Є—Б–Ї—Г —Б—В–∞—В–µ–є¬†вЗС¬†¬†Back to the list of articles
–Э–∞ –≥–ї–∞–≤–љ—Г—О¬†вЗС To main
–Ъ —Б–њ–Є—Б–Ї—Г —Б—В–∞—В–µ–є¬†вЗС¬†¬†Back to the list of articles
–Ь–µ—В–Ї–Є: –Ї—Г–њ–Є—В—М –Ї–≤–∞—А—В–Є—А—Г –љ–∞ –≤—В–Њ—А–Є—З–љ–Њ–Љ —А—Л–љ–Ї–µ
213 –Ї–Њ–Љ–Љ–µ–љ—В–∞—А–Є–µ–≤ –Ї –Ј–∞–њ–Є—Б–Є "–° –Я—А–∞–Ј–і–љ–Є–Ї–Њ–Љ –Т–µ—Б–љ—Л –Т–∞—Б, –Ф—А—Г–Ј—М—П!"
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Compact and durable, CNC precision machined corrosion-resistant POM and acrylic housing.
Lightweight, ergonomically designed.
Maximum Operating Depth (MOD) of 50 meters (164 feet).
Fixed Lens Port with built in M67 Adapter.
Port Control Ring Dial.
Control Wheel push button functions.
New RECSEA dial locking system for easier opening and closing.
Quality silicone O-ring.
Complete camera function control.
|Function / Efficiency
|Depth rating
|50m / 164 ft.
|Canon PowerShot G7 X

subset: commoncrawl


text:
The details:
- Thread: Clark's Big Ball, size 30
- Needles: 2.25mm
- Finished size: 13 inches in diameter
This one and the sunshine one are beautiful! How is retirement going?
I really like your combination of thread and pattern here - they seem to be meant for each other.
Love it! Who said not to knit with pretty colors?!
Oooooo! Pretty! I like white doilies, but there's nothing wrong with variegated. I've got a bunch made by my grandmother, and have made one or two myself. Love yours!
very nice thank you


text:
Monday, August 29, 2011
FIND + SHARE: rhetorical tropes
Mr. Bradbury Thompson. This to me is an example of metonymy. By replacing the stripes of the flag with the colors of the rainbow he transforms the message. The colors represent the larger idea of beauty, diversity, and freshness.
Posted by Ivan Alonso at 10:54 AM No comments:
Labels: vislang
Thursday, August 25, 2011
Promotional Intro Polylux from Sebastian Lange on Vimeo.
Oil'd from Chris Harmon on Vimeo.
Posted by Ivan Alonso at 8:25 PM No comments:
Labels: Narrative S+M
Monday, August 22, 2011
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text:
BnB Rack Republic 3 Bike Rear Carrier
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Buzz Rack Beetle 4×4 2 Bike Carrier – Spare Tyre Mount
TECHNICAL SPECIFICATIONS Max number of bikes: 2 Dimensions (folded): 68 x 67 x 15 cm Weight: 5.7kg Max load capacity: 30kg Max weight per bike: 15kg Integrated lighting board: no Locking: no The carrier cannot be mounted to cars that have a plastic spoiler.
TECHNICAL SPECIFICATIONS Max number of bikes: 2 Fits bolt on tow ball: yes Fits swan neck / detachable tow ball: yes Dimensions (width x depth): 114cm x 56cm (measured from the centre of the tow ball mount to the outside edge of the number plate holder). Dimensions (folded): 114 x...
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Features & Highlights MaxxHaul Hitch Adapter, 1-1/4" to 2" Hitch Converter Allowing for 4" Rise & 3-3/8" Drop Rugged Full Steel Construction with Powder Coat Finish to Resist Rust and Corrosion Perfect for Tow Hitch Accessories like Bike Racks, Cargo Carriers and the Like (UNIT NOT FOR TOWING) Distance between...
Saris Freedom 4 Bike Platform Rack
Saris Hitch Bike Racks - SA4414B-FB This platform-style, 4-bike rack has wheel trays designed specifically for fat tires. Cradles with cushioned straps securely grip your bike frames, and a front-mounted push lever lets you tilt the rack down with bikes loaded for cargo area access.
THULE 9027 Apex Swing Away Bike Rack
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text:
The human genome is subject to constant attack by endogenous and environmental DNA damaging agents. Ifunrepaired, DNA lesions will give rise to mutations that in turn may lead to cancer formation. Fortunately, acomplex network of DNA repair pathways operates to remove DNA lesions. To assess the biologicalsignificance of exposure to environmental DNA damaging agents, it is necessary to understand the details ofthe complex cellular response to DNA damage. Unlike the conserved LIG1 and LIG4 genes, lower eukaryoteslack a homolog of the mammalian LIG3 gene, which encodes at least three distinct polypeptides. Interestingly,the DNA ligase III -associated proteins, poly (ADP-ribose) polymerase 1 (PARP-1), XRCC1 and DNApolymerase (Pol) , each of which have been implicated in base excision repair and the repair of DNA singlestrand breaks, are also found only in higher eukaryotes. Using a modified yeast two hybrid assay, we haveidentified a series of XRCC1 mutants that are defective in specific protein-protein interactions.
In Specific Aim1, we will utilize these mutants to delineate the functional and biological consequences of protein-proteininteractions between DNA ligase III /XRCC1 and other proteins involved in base excision and single strandbreak repair. Recent studies have increased the repertoire of DNA repair transactions in which DNA ligaseIII /XRCC1 participates.
In Specific Aim 2, we will determine how DNA ligase III /XRCC1 is recruited to theDNA nucleotide excision repair machinery and whether this involves an interaction between XRCC1 andPCNA. In preliminary studies, we have identified an interaction between DNA ligase III /XRCC1 andhRad50/hMre11/Nbs.
In Specific Aim 3, we will determine how DNA damage regulates this interaction andwhether these proteins act together in an error-prone non-homologous end-joining sub pathway that repairsDNA double strand breaks. Interestingly, this error-prone pathway is up-regulated in cancer cells and maycontribute to their characteristic genomic instability.
In Specific Aim 4, we will identify and characterize smallmolecule inhibitors of DNA ligase III. We envision that that these inhibitors will not only be valuable reagentsfor elucidating the cellular functions of the LIG3 gene products but also may serve as lead compounds for thedevelopment of novel anti-cancer agents.
It is well established that genomic instability drives the progression from a normal cell into a cancer cell. Human cells have a complex network of pathways that act together to maintain genome stability. A mechanistic understanding of these pathways will provide fundamental insights into tumor suppression. In addition, genomic instability is a characteristic of tumor cells, indicating that there are differences in the pathways that normally maintain stability. These differences between normal and cancer cells offer an opportunity to develop therapeutic strategies that selectively target cancer cells.
|Cannan, Wendy J; Rashid, Ishtiaque; Tomkinson, Alan E et al. (2017) The Human Ligase III?-XRCC1 Protein Complex Performs DNA Nick Repair after Transient Unwrapping of Nucleosomal DNA. J Biol Chem 292:5227-5238
|Greco, George E; Matsumoto, Yoshihiro; Brooks, Rhys C et al. (2016) SCR7 is neither a selective nor a potent inhibitor of human DNA ligase IV. DNA Repair (Amst) 43:18-23
|Sallmyr, Annahita; Matsumoto, Yoshihiro; Roginskaya, Vera et al. (2016) Inhibiting Mitochondrial DNA Ligase III? Activates Caspase 1-Dependent Apoptosis in Cancer Cells. Cancer Res 76:5431-41
|Kukshal, Vandna; Kim, In-Kwon; Hura, Gregory L et al. (2015) Human DNA ligase III bridges two DNA ends to promote specific intermolecular DNA end joining. Nucleic Acids Res 43:7021-31
|Ghezraoui, Hind; Piganeau, Marion; Renouf, Benjamin et al. (2014) Chromosomal translocations in human cells are generated by canonical nonhomologous end-joining. Mol Cell 55:829-842
|Tobin, L A; Robert, C; Rapoport, A P et al. (2013) Targeting abnormal DNA double-strand break repair in tyrosine kinase inhibitor-resistant chronic myeloid leukemias. Oncogene 32:1784-93
|Tomkinson, Alan E; Sallmyr, Annahita (2013) Structure and function of the DNA ligases encoded by the mammalian LIG3 gene. Gene 531:150-7
|Tomkinson, Alan E; Howes, Timothy R L; Wiest, Nathaniel E (2013) DNA ligases as therapeutic targets. Transl Cancer Res 2:
|Della-Maria, Julie; Hegde, Muralidhar L; McNeill, Daniel R et al. (2012) The interaction between polynucleotide kinase phosphatase and the DNA repair protein XRCC1 is critical for repair of DNA alkylation damage and stable association at DNA damage sites. J Biol Chem 287:39233-44
|Dey, Sanjib; Maiti, Amit K; Hegde, Muralidhar L et al. (2012) Increased risk of lung cancer associated with a functionally impaired polymorphic variant of the human DNA glycosylase NEIL2. DNA Repair (Amst) 11:570-8
Showing the most recent 10 out of 29 publications


text:
Based on the novel by Irvine Welsh – and released in UK cinemas on October 4th – James McAvoy, Jamie Bell, Jim Broadbent, Eddie Marsan and Imogen Poots star in the movie Filth. Rather a personality flaw than something that can physically be wiped away – the movie is based on a corrupt policeman who will stop at nothing to get what he wants.
Brilliantly played by James McAvoy, the bad cop exploits the power of his badge – and the likes of his colleagues – for a promotion. As he exposes their secrets and steals their wives Bruce begins to lose himself in this "brilliantly twisted" film.
As his past resurfaces, along with a missing wife, uncontrollable drug habit, and suspicious colleagues – Bruce begins to lose his sanity. The question is: can the bigoted policeman get clean enough to disentangle himself from the filth?


text:
Alan Pardew has already spoken to Malky Mackay the Cardiff City manager about 19 year-0old Haris Vuckic, and the Scot seems happy with Haris so far.
Haris Vuckic – with manager Mackay behind him
Vuckic made his debut last Saturday for the Welsh side, but he was taken aback by the pace of the game, and was replaced at half time.
But the Slovenian was much better on Tuesday night, and he scored Cardiff's third goal in the 3-1 win over Peterborough, which was much easier than the score suggested, with Peterborough getting their goal in injury time.
Alan Pardew is a keen believer in sending his youngsters out to get games on loan, and he thinks Vuckic will be a better player for the experience:
"I spoke to Malky Mackay on Wednesday morning, and he's very happy with Haris,"
"He had a start last weekend against Leicester City, and came off at half-time. I think the pace of the division caught him out a bit."
"He was a lot better against Peterborough. He scored a good goal, and is up and running there now."
"I'm sure he'll do very well for Cardiff. He'll benefit from the loan."
It often takes a loan spell to bring a youngster up to Premier League standard and if Haris can get a number of games – Cardiff still have 15 games to play this season – he should be much improved from the playing time he will get in what we know is a tough league.
Malky Mackay had this to say about the Newcastle 19 year-old central midfielder:
"Vuckic is a footballer who has talent, can see a pass, and gets into great areas." "He's calm under pressure, and I was delighted that he scored."
"The factors that will bring him on again are game awareness and adapting to the frenetic nature of Championship football."
"He'll learn from matches, and by playing with players like Peter Whittingham."
Next up for Cardiff City is an away game at Ipswich Town tomorrow afternoon, and we'll be looking for the result of the game and how Haris fares.
Vuckic' intial loan runs out in mid-March, so we'll have to see how he does at Cardiff, and whether the Welsh club want to extend the loan, but it seems that Alan Pardew would be willing to do that.
And when you think of Haris you think of our other top 19 year-old central midfielder Mehdi Abeid, and it seems Alan is ready to to allow Abeid to also go out on loan, once they find a suitable club for him.
This is what Alan said about the French U19 and Algerian U23 player:
"We also want Mehdi out on loan, but we haven't found a club for him yet,"
James Tavernier is another youngster who is getting first team experience, and the right-back is currently out on loan with Alan Smith at MK Dons.
James has played over 45 games on loan over the last year at Gateshead, Carlisle, Sheffield Wednesday and now MK Dons, and he'll be a much better player for it when he reports to pre-season training in early July.
We're hoping both Harris Vuckic and Mehdi Abeid will get a number of games before the end of the season on loan, and then all three could be challenging for first team positions next season.
We're sure that's the plan in any case.
Comments welcome.
15 comments so far
This is totally the best strategy for bringing on our young talent. Especially as youth development is the foundation stone of our player development. Cardiff are a good club now. We need to have some partnerships where AP has a good relationship with the coaching and management teams in the receiving club so we know our guys are getting the right experience.
Team for Wolves,
Simmo/Raylor Willo Colo Santon
Cabaye Guthrie
Cisse Benny
I think that is the best we can offer especially with raylor at right back(suspect defensively to be fair) as it gets all or best technical players on the pitch. Look at the passing ability of that team and with that front three goals will flow. What do ye Think?
ROSHAN, agreed mate he will get more games out on loan, i guess im speaking a little selfishly thinking he can help out with jonas' workload ie giving him 20mins or so gets him some playing time and jonas 20mins rest, so helps us out in the short term but yes your right full games in the championship will deffo help him more in the long run


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In five years' time, with high immigrant birth rates and our generous benefit system, another huge number of children will need schools and all will want use of our NHS, our police resources and, yes, our benefits.
While a right-wing society has to be kept under scrutiny for worst aspects of racism, we must mimic New Zealand and Australia and only take who we need, be they plasterers, policemen or postmen.
Please don't anyone play 'the race card'. It's not about race, it's about numbers.
No ifs, no buts, the UK is simply too small to absorb half-a-million immigrants every two years.
But EU rules are categoric – free movement of labour is 'non-negotiable', meaning the only way (currently) is 'out'.
Jon Cole
Blount Road, Old Portsmouth


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MARICOPA, Ariz. - UC Santa Barbara shot a final round 291 to break a tie for third-place with the host University of Wyoming and Nebraska on Sunday in the final round of the Cowboy Southern Dunes Tournament at Southern Dunes Golf Course in Maricopa, Ariz.
The third-place finish for the Gauchos was particularly solid as they used several new players in the opening tournament of the season.
One of the new players, freshman Zach Smith, tied for the lowest final round at 3-under par, to finish at 2-under for the tournament, tying for fifth-place. Will Strauss shot even-par in the final round to end the tournament at 5-under par, 221, tying for 16th overall.
Hunter Robinson also carded an even-par 72 to finish at 6-over and tie for 19th-place.
Mike Smith (12-over par, 228) and Brandon Bauman (14-over par, 230) tied for 30th and 35th-place respectively.
The University of Idaho won the team title easily. The Vandals finished 10-under par, 17 shots ahead of second-place San Francisco. The Gauchos were 25 shots back while UC Irvine and Wyoming tied for fourth, 34 off the pace.
Idaho's Jared du Toit won the individual honors shooting a 206, 10-under par, one shot ahead of Arizona State's Mathias Schjoelberg who was playing as an individual UC Irvine's Peter Fernandez was third a 4-under par 212.
UCSB returns to action on Monday, Oct. 20 when it travels to the Bill Cullum Invitational at Wood Ranch Country Club in Simi Valley, Calif.


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Steak Salad with Mint, Lime & Cilantro Rice
The technique for cooking the beef in this dish involves marinating it in fish sauce and then searing it quickly. Cutting the steak into pieces creates more surface area for caramelized flavors to develop and complement the exhilarating combination of mint, cilantro, lime and a hint of red chili flake, characteristic of Thai-style cuisine. This dashing meal is best served on a warm summer night on the back porch.
Prep Time: 20 Min Cook Time: 15 Min