text: The top-cited systematic reviews/meta-analyses in tuberculosis research: A PRISMA-compliant systematic literature review and bibliometric analysisZhang, Yonggang PhD; Huang, Jin PhD; Du, Liang PhD Section Editor(s): Liu., Jian Medicine: February 2017 - Volume 96 - Issue 6 - p e4822 doi: 10.1097/MD.0000000000004822 Research Article: Systematic Review and Meta-Analysis Abstract In Brief Author InformationAuthors Article OutlineOutline Article MetricsMetrics Background: The top-cited systematic reviews/meta-analyses in tuberculosis research have not been identified. The objective of this study was to identify the 100 top-cited systematic reviews/meta-analyses in tuberculosis research, and to understand factors resulting in highly cited works, and establish trends in systematic reviews/meta-analyses in tuberculosis research. Methods: The Web of Science Core Collection was searched for systematic reviews/meta-analyses on tuberculosis up to January 31, 2016. Articles were ranked by citation count and screened by 2 authors. The following information was collected and analyzed from each included study: citation of Web of Science Core Collection, author, country, year, journal, institution, page number, and reference number. Results: The 100 top-cited studies were cited from 54 to 662 times and were published between 1997 and 2014. Ten authors have more than 1 study as the first author and 10 authors have more than 1 study as corresponding author. The country with the most top-cited studies was USA (n = 26). The institutions with the largest number of the studies were McGill University in Canada (n = 18). The studies were published in 32 journals, whereas 12 were published in PloS Medicine, followed by Lancet Infectious Diseases (n = 11). Conclusions: Developed countries and high-impact journals may publish more top-cited systematic review/meta-analysis in tuberculosis research. Supplemental Digital Content is available in the text aDepartment of Periodical Press, West China Hospital, Sichuan University, Chengdu, Sichuan, China bCentre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, Northern Ireland, UK cThe Chinese Cochrane Centre, West China Hospital, Sichuan University, Chengdu, China. Correspondence: Yonggang Zhang, Department of Periodical Press, West China Hospital, Sichuan University, Chengdu, Sichuan, China (e-mail: email@example.com; Liang Du, Department of Periodical Press, West China Hospital, Sichuan University, Chengdu, Sichuan, China (e-mail: firstname.lastname@example.com). Abbreviations: PRISMA = Preferred Reporting Items for Systematic Reviews and Meta-analysis, TB = tuberculosis. The study was supported by grant 81403276 from the National Natural Science Foundation of China and grant 2016SZ0016 from the Science and Technology Department of Sichuan Province. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The authors have no conflicts of interest to disclose. Supplemental Digital Content is available for this article. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (www.md-journal.com). This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 Received February 29, 2016 Received in revised form July 29, 2016 Accepted August 18, 2016 Abstract 1 Introduction 2 Materials and methods 2.1 Study search 2.2 Inclusion and exclusion criteria 2.3 Data extraction and analysis 3 Result 3.1 The main characteristics of the included studies 3.2 Distribution of authors 3.3 Distribution of countries 3.4 Distribution of institutions 3.5 Distribution of published years 3.6 Distribution of published journals 4 Discussion 5 Conclusions References Supplemental Digital Content Back to Top | Article Outline 1 Introduction Tuberculosis (TB) is a widespread, chronic infectious disease caused by Mycobacterium tuberculosis.[1,2] TB generally affects the lungs, but can also affect other parts of the body.[3] One-third of the world's population is thought to have been infected with M tuberculosis. [4] The World Health Organization (WHO) reported that 9.6 million people fell ill with TB and 1.5 million died from TB in 2014.[5] It is urgent to study the etiology, prevention, diagnostic, and treatment of TB.[6] Although there are many studies in the same topic in TB researches, however, the results may be inconclusive.[7] Since the using of systematic review/meta-analysis, studies in the same topic can be pooled and give more precise results.[8] Systematic review/meta-analysis tries to appraise, select, and synthesize all high-quality research evidence relevant to a certain question.[9] It aims at seeking patterns among study results and agreement or disagreement among those results.[10,11] Up to now, there have been many systematic reviews/meta-analyses in the field of TB research,[12–15] and these studies have contributed too many fields of controlling TB. However, the performance, productivity, and impact of these studies are still unknown. To evaluate the current body of these studies, detecting trends is urgent for future TB researches. Bibliometric analysis is the most important method.[16,17] One of the most useful methodologies of bibliometric analysis is citation analysis, which will examine a network of published articles to assess the individual article's impact and influence on its field.[18,19] Many journals have published the most cited articles in their given field, such as radiology,[17] diabetes,[20] and so on. Previously, we reported the most cited studies in the field of TB[16]; we felt that study was still needed to be strength because we did not report the results in the specific filed. Considering the systematic reviews/meta-analyses contributing in many ways of TB, thus, we performed the current study. The purpose of this study was to identify and analyze the 100 most cited systematic reviews/meta-analyses in TB research across all peer-reviewed scientific journals. This bibliometric analysis reflects the most influential systematic reviews/meta-analyses to date in TB field and helps to identify future trends in TB research. Back to Top | Article Outline 2 Materials and methods This is a bibliometric analysis, so ethical approval was not required for the study. The study was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) statement.[21] Back to Top | Article Outline 2.1 Study search We performed a bibliometric analysis of the most highly cited systematic reviews/meta-analyses in the field of TB on January 31, 2016. All journals in Web of Science Core Collection were eligible for inclusion. The following search terms were used: "tuberculosis" or "TB" or "tuberculo*" and "systematic review" or "meta-analysis." The search results were sorted by number of citations. Back to Top | Article Outline 2.2 Inclusion and exclusion criteria The following inclusion criteria were used: the study should be a systematic review or meta-analysis in the field of TB research; the studies should be articles, reviews, editorials, or research letters. The exclusion criteria were as follows: abstracts, correction; study that mentioned the word "tuberculosis," but not deal with TB. Back to Top | Article Outline 2.3 Data extraction and analysis The 100 top-cited systematic reviews/meta-analyses were identified based on the citations. Two authors independently extracted the following information from each study: number of citations, authors, corresponding authors (contact authors), authors' address, Journal, year, country of origin, number of references, and number of page. We analyzed the relationship between citations and distribution of authors, countries, institutions, years, and journals. The country was determined on the basis of the address of the first author, whereas the institution was determined on the basis of the address of corresponding author. If the first author and corresponding author had more than 1 address, the first address was used for analysis. Any disagreement was resolved by discussion or decided by the third author. Back to Top | Article Outline 3 Result 3.1 The main characteristics of the included studies The Supplement Table 1 (http://links.lww.com/MD/B320) shows characteristics of the 100 top-cited TB systematic reviews/meta-analyses in descending order. The number of citation of these studies varies from 54 to 662, with a total citation of 13,090. The most cited study with a total of 662 citations was about T-cell-based assays for the diagnosis of latent TB infection,[22] and this study was published in 2008 by Pai et al in Annals of Internal Medicine. The second study was a meta-analysis on new tests for the diagnosis of latent TB infection, published in Annals of Internal Medicine in 2007 by Menzies et al[23] The third most cited study with 559 citations,[24] with the title "Interferonn assays-gamma in the immunodiagnosis of tuberculosis: a systematic review," was published in Lancet Infectious Diseases in 2004 by Pai et al. The reference numbers for the included studies were from 10 to 470, with an average of 69 references. The page numbers for the included studies were from 4 to 171, with an average of 13 pages. Back to Top | Article Outline 3.2 Distribution of authors Forty-one studies had less than 5 authors, and 11 studies had more than 10 authors. In quantitative terms, 10 authors have more than 1 study in 100 top-cited articles as the first authors, and 10 authors have more than 1 study as corresponding author (Table 1). The author with most studies as corresponding author was Pai (n = 17). Table 1 Back to Top | Article Outline 3.3 Distribution of countries The 100 top-cited TB systematic reviews/meta-analyses were from 21 countries (Australia, Belgium, Brazil, Canada, Chile, China, England, France, Germany, Italy, Mexico, Nepal, The Netherlands, Norway, Saudi Arabia, South Africa, Spain, Switzerland, Uganda, USA, and Wales). The country with the most top-cited systematic review/meta-analysis was USA with 26 studies, followed by Canada with 22 studies, Switzerland with 22 studies, England with 8 studies, and China with 6 studies. The country with the most citations was Canada with 3648 citations, followed by USA with 3494 citations. The country with most average citations was Norway with 242 citations, followed by Canada with 166 citations (Table 2). Table 2 Back to Top | Article Outline 3.4 Distribution of institutions A total of 13 institutions with more than 2 studies were included (Table 3). The institutions with the largest number of the articles were McGill University in Canada (n = 18) and University of California, Berkeley in USA (n = 7), followed by WHO (n = 6), Harvard University (n = 4). Table 3 Back to Top | Article Outline 3.5 Distribution of published years Year distribution of the 100 top-cited studies is list in Table 4. These studies were published from 1997 to 2014. The year with most studies was 2008 with 15 studies, followed by 2007 with 13 studies. The year with most citations was 2008 with 2439 citations, followed by 2006 with 1348 citations. The year with most average citation was 2002 with 323, followed by 2004 with 251. Table 4 Back to Top | Article Outline 3.6 Distribution of published journals The 100 studies were published in 32 journals (Table 5). The journal with the largest number of the articles cited was PloS Medicine (n = 12), followed by Lancet Infectious Diseases (n = 11) and International Journal of Tuberculosis and Lung Disease (n = 10). The journal with most citations was Lancet Infectious Diseases with 1962 citations, followed by PloS Medicine with 1522 citations and Annals of Internal Medicine with 1319 citations. The journal with the highest average number of citations per article was Annals of Internal Medicine with 440 citations, followed by Lancet with 240 citations. Table 5 Back to Top | Article Outline 4 Discussion In recent years, with the prevalence of HIV[25] and drug-resistant MTB,[26] TB has become a dire threat to human health. TB research is also one of the most important research topics of medical researchers. Systematic review/meta-analysis in the field of TB provides many evidence for prevention, diagnosis, and treatment of TB. However, no citation analysis focused on this field; thus, we performed the current study to identify the 100 top-cited TB systematic reviews/meta-analyses and to analyze their principal characteristics. The number of citations for the 100 top-cited systematic reviews/meta-analyses ranged from 54 to 662, which is far more less that the number of citation of 100 top-cited studies on TB (366–4443), which suggest that the popularization of systematic reviews/meta-analyses remains to be improved. In our study, 100 top-cited studies were published from 1997 to 2014, except 2001. Most of the studies were published in 2000, which is consistent with the development of the methods of systematic review/meta-analysis. The top 3 ranked studies are all about the T-cell-based assays for diagnosis of TB,[22–24] which partly suggested the diagnosis of TB, especially for latent TB infection, is still the most difficult and important research topic for TB. The number 1 ranked study is a systematic review about the T-cell-based assays for the diagnosis of latent TB infection. Based on the records in the Web of Science Core Collection, this study has been cited in many other research areas, including rheumatology, pediatrics, gastroenterology, dermatology, surgery, and so on. It has also been cited in 7 languages, including English, French, Portuguese, Italian, Spanish, German, and Polish, which indicated the study had an effect worldwide. Consistent with similar studies, almost half included articles were from USA and Canada.[16] The institutions with largest numbers of the articles were McGill University in Canada and University of California, Berkeley, in USA. It closely related to the influence and scientific output of the field of TB in Canada and USA. Some developing counties, such as China, Mexico, and Nepal, also published some top cited systematic review/meta-analysis. However, no study was from India, the country with heaviest burden of TB. In addition, no study from developing country ranked in the top 10. The only 1 study from a developing country ranked in top 20 cited studies[27] was an international cooperative study between South Africa, England, and Norway. The developed countries may pay more attention on the topic and have more funds. The results from our analysis indicated that the most highly cited systematic reviews/meta-analyses were published in journals related to infectious and respiratory diseases, such as International Journal of Tuberculosis and Lung Disease, Lancet Infectious Diseases, and European Respiratory Journal. Comprehensive medical periodicals have published articles among top 100-cited as well, like PloS Medicine, PloS One, and BMJ. We have to mention the International Journal of Tuberculosis and Lung Disease. This journal has a relative lower impact factor than most of the included journals. However, a total of 10 articles published in the journal were included.[28–37] They ranked 21st,[28] 31st,[29] 44th,[30] 54th,[31] 59th,[32] 76th,[33] 77th,[34] 80th,[35] 97th,[36] and 99th.[37] They all have been cited more than 50 times. Because the history of research tells us that milestone papers can be rejected when they first submitted;[20,38] thus, to reveal some gold papers, the editors, reviewers should keep guard on quality and be more open to the arriving manuscripts.[20,38] There are several limitations of this study. First, the current study was only based on journal studies from Web of Science database. Web of Science does not index all journals and there are other databases available for citation analysis (such as Scopus and Google Scholar). Therefore, there may be some missed literature. Thus, our results should be explained with caution. Second, when we analyzed the origin country, our study was based on the institution address of corresponding author. If the author changes the address, there might be statistic bias. Third, there may be many factors that influence the number of citations for one study. We did not analyze self-citation, citations in textbooks, lectures, and journals not included by Web of Science Core Collection.[20] In addition, some authors might cite studies in some journals in which they hoped to publish their research.[20] Fourth, there might be some important and influential articles with lower citation numbers that were not included. After all, Web of Science Core Collection includes the most influential studies worldwide with short updating period, our study have the enormous advantage. The aim of the current study was to analyze the-top cited systematic review/meta-analysis in TB research, which is partly different from other bibliometric studies in the field of radiology and diabetes. First, systematic review/meta-analysis analyzes disagreement conclusions and gives conclusive results, which will impact longer than original studies in clinical practice. Second, the average citations included in current study might increase quicker than those in our previous study. Third, the summary of the most conclusive research in TB research field may have more implication for the future clinical practices and research work. Back to Top | Article Outline 5 Conclusions In conclusion, the current study is the first bibliometric assessment of the TB systematic reviews/meta-analyses. Developed countries and high-impact journals may publish more top cited systematic review/meta-analysis in the field of TB.Back to Top | Article Outline References [1]. Dheda K, Barry CE 3rd, Maartens G. Tuberculosis. Lancet 2016;387:1211–26. Cited Here... [2]. Yen YF, Chuang PH, Yen MY, et al. Association of body mass index with tuberculosis mortality: a population-based follow-up study. Medicine (Baltimore) 2016;95:e2300. Cited Here... [3]. Prideaux B, Via LE, Zimmerman MD, et al. The association between sterilizing activity and drug distribution into tuberculosis lesions. Nat Med 2015;21:1223–7. Cited Here... [4]. Waltl S. Regulator of dendritic cell migration, ASAP1 is associated with increased susceptibility to tuberculosis. Clin Genet 2015;88:530–1. Cited Here... [5]. Mohajan HK. Tuberculosis is a fatal disease among some developing countries of the world. Am J Infect Dis Microbiol 2015;3:18–31. Cited Here... [6]. Zhou Q, Chen YQ, Qin SM, et al. Diagnostic accuracy of T-cell interferon-gamma release assays in tuberculous pleurisy: a meta-analysis. Respirology 2011;16:473–80. Cited Here... [7]. Cattamanchi A, Smith R, Steingart KR, et al. Interferon-gamma release assays for the diagnosis of latent tuberculosis infection in HIV-infected individuals: a systematic review and meta-analysis. J Acquir Immune Defic Syndr 2011;56:230–8. Cited Here... [8]. Diel R, Goletti D, Ferrara G, et al. Interferon-gamma release assays for the diagnosis of latent Mycobacterium tuberculosis infection: a systematic review and meta-analysis. Eur Respir J 2011;37:88–99. Cited Here... [9]. Zhang H, Li X, Huang J, et al. Comparative efficacy and safety of prostacyclin analogs for pulmonary arterial hypertension: a network meta-analysis. Medicine (Baltimore) 2016;95:e2575. Cited Here... [10]. Rhodes KM, Turner RM, Higgins JP. Predictive distributions were developed for the extent of heterogeneity in meta-analyses of continuous outcome data. J Clin Epidemiol 2015;68:52–60. Cited Here... [11]. Tseng PT, Chen YW, Chung W, et al. Significant effect of valproate augmentation therapy in patients with schizophrenia: a meta-analysis study. Medicine (Baltimore) 2016;95:e2475. Cited Here... [12]. Falzon D, Gandhi N, Migliori GB, et al. Resistance to fluoroquinolones and second-line injectable drugs: impact on multidrug-resistant TB outcomes. Eur Respir J 2013;42:156–68. Cited Here... | PubMed [13]. Faustini A, Hall AJ, Perucci CA. Risk factors for multidrug resistant tuberculosis in Europe: a systematic review. Thorax 2006;61:158–63. Cited Here... [14]. Jacobson KR, Tierney DB, Jeon CY, et al. Treatment outcomes among patients with extensively drug-resistant tuberculosis: systematic review and meta-analysis. Clin Infect Dis 2010;51:6–14. Cited Here... [15]. Jeon CY, Murray MB. Diabetes mellitus increases the risk of active tuberculosis: a systematic review of 13 observational studies. PLoS Med 2008;5:e152. Cited Here... [16]. Chen LM, Liu YQ, Shen JN, et al. The 100 top-cited tuberculosis research studies. Int J Tuberc Lung Dis 2015;19:717–22. Cited Here... [17]. Dolan RS, Hanna TN, Warraich GJ, et al. The top 100 articles in the radiology of trauma: a bibliometric analysis. Emerg Radiol 2015;22:667–75. Cited Here... | PubMed [18]. Seriwala HM, Khan MS, Shuaib W, et al. Bibliometric analysis of the top 50 cited respiratory articles. Expert Rev Respir Med 2015;9:817–24. Cited Here... [19]. Tahiri Y, Fleming TM, Greathouse T, et al. Analysis of the 50 most cited papers in craniofacial surgery. J Craniomaxillofac Surg 2015;43:2152–7. Cited Here... [20]. Zhao X, Guo L, Lin Y, et al. The top 100 most cited scientific reports focused on diabetes research. Acta Diabetol 2016;53:13–26. Cited Here... [21]. Li H, Zhao X, Zheng P, et al. Classic citations in main primary health care journals: a PRISMA-compliant systematic literature review and bibliometric analysis. Medicine (Baltimore) 2015;94:e2219. Cited Here... [22]. Pai M, Zwerling A, Menzies D. Systematic review: T-cell-based assays for the diagnosis of latent tuberculosis infection: an update. Ann Intern Med 2008;149:177–84. Cited Here... [23]. Menzies D, Pai M, Comstock G. Meta-analysis: new tests for the diagnosis of latent tuberculosis infection: areas of uncertainty and recommendations for research. Ann Intern Med 2007;146:340–54. Cited Here... [24]. Pai M, Riley LW, Colford JM Jr. Interferon-gamma assays in the immunodiagnosis of tuberculosis: a systematic review. Lancet Infect Dis 2004;4:761–76. Cited Here... [25]. Bucher HC, Griffith LE, Guyatt GH, et al. Isoniazid prophylaxis for tuberculosis in HIV infection: a meta-analysis of randomized controlled trials. AIDS 1999;13:501–7. Cited Here... [26]. Migliori GB, Sotgiu G, Gandhi NR, et al. Drug resistance beyond extensively drug-resistant tuberculosis: individual patient data meta-analysis. Eur Respir J 2013;42:169–79. Cited Here... [27]. Munro SA, Lewin SA, Smith HJ, et al. Patient adherence to tuberculosis treatment: a systematic review of qualitative research. PLoS Med 2007;4:e238. Cited Here... [28]. Sterne JA, Rodrigues LC, Guedes IN. Does the efficacy of BCG decline with time since vaccination? Int J Tuberc Lung Dis 1998;2:200–7. Cited Here... [29]. Slama K, Chiang CY, Enarson DA, et al. Tobacco and tuberculosis: a qualitative systematic review and meta-analysis. Int J Tuberc Lung Dis 2007;11:1049–61. Cited Here... [30]. Mandalakas AM, Detjen AK, Hesseling AC, et al. Interferon-gamma release assays and childhood tuberculosis: systematic review and meta-analysis. Int J Tuberc Lung Dis 2011;15:1018–32. Cited Here... [31]. Mase SR, Ramsay A, Ng V, et al. Yield of serial sputum specimen examinations in the diagnosis of pulmonary tuberculosis: a systematic review. Int J Tuberc Lung Dis 2007;11:485–95. Cited Here... [32]. Greco S, Girardi E, Masciangelo R, et al. Adenosine deaminase and interferon gamma measurements for the diagnosis of tuberculous pleurisy: a meta-analysis. Int J Tuberc Lung Dis 2003;7:777–86. Cited Here... [33]. Gao L, Tao Y, Zhang L, et al. Vitamin D receptor genetic polymorphisms and tuberculosis: updated systematic review and meta-analysis. Int J Tuberc Lung Dis 2010;14:15–23. Cited Here... [34]. Hirsch-Moverman Y, Daftary A, Franks J, et al. Adherence to treatment for latent tuberculosis infection: systematic review of studies in the US and Canada. Int J Tuberc Lung Dis 2008;12:1235–54. Cited Here... [35]. Li HT, Zhang TT, Zhou YQ, et al. SLC11A1 (formerly NRAMP1) gene polymorphisms and tuberculosis susceptibility: a meta-analysis. Int J Tuberc Lung Dis 2006;10:3–12. Cited Here... [36]. Lewis SJ, Baker I, Davey Smith G. Meta-analysis of vitamin D receptor polymorphisms and pulmonary tuberculosis risk. Int J Tuberc Lung Dis 2005;9:1174–7. Cited Here... [37]. Sun F, Chen Y, Xiang Y, et al. Drug-metabolising enzyme polymorphisms and predisposition to anti-tuberculosis drug-induced liver injury: a meta-analysis. Int J Tuberc Lung Dis 2008;12:994–1002. Cited Here... [38]. Porta M. Acta Diabetologica is 50 and well: long live Acta!. Acta Diabetol 2014;51:1–3. Cited Here... Keywords:bibliometric; meta-analysis; systematic review; tuberculosis Supplemental Digital Content MD_2016_09_19_ZHANG_MD-D-16-01400_SDC1.doc; [Word] (25 KB) Back to Top | Article OutlineCopyright © 2017 The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved.


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Sail with us in the breathtaking sunset and take inthe beautiful scenery while having cocktails. With the option of a night swim in the warm waters of White Rocks beach or dance the night away while enjoying a romantic dinner* under the stars.
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Our holdings include hundreds of glass and film negatives/transparencies that we've scanned ourselves; in addition, many other photos on this site were extracted from reference images (high-resolution tiffs) in the Library of Congress research archive. (To query the database click here.) They are adjusted, restored and reworked by your webmaster in accordance with his aesthetic sensibilities before being downsized and turned into the jpegs you see here. All of these images (including "derivative works") are protected by copyright laws of the United States and other jurisdictions and may not be sold, reproduced or otherwise used for commercial purposes without permission.
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January 1943. "Indiana Harbor Belt R.R. switchman demonstrating signal with a 'fusee,' used at twilight and dawn when visibility is poor. This signal means 'back up.' Calumet City, Illinois." Kodachrome by Jack Delano. View full size.
Ayer Mill clock tower, Lawrence, Massachusetts. January 1941. View full size. 4x5 Kodachrome transparency by Jack Delano.
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April 1943. Illinois Central R.R. freight cars at the South Water Street freight terminal, Chicago. The C & O and Nickel Plate Railroads lease part of this terminal. View full size. 4x5 Kodachrome transparency by Jack Delano.


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This 3 bedroom detached villa is part of a new development in the Luz de Tavira region. Construction is well underway and is being managed by a highly experienced developer, one who has completed and sold multiple units through Ideal Homes previously. There will be a total of 15 detached properties, each with their own private pool sized 7mx3m, landscaped gardens and a carport - accessible by electric gates. Comprised of 3 bedrooms, all en-suites, along with an open plan lounge and kitchen which leads straight out into the garden. Currently being designed with luxury furnishings and high quality products, this developer has taken feedback from previous developments and is implementing them into this one, making this their best one yet - ticking all the boxes when it comes to convenience, quality and build.The kitchen will be fitted with all the necessities although more appliances/items can be installed at a later date at an extra cost. All villas enjoy spectacular sea views, are close to all needed amenities and public transportation can be found just a short walk away. Located at just 5 mins into the centre of Tavira and only 20 minutes to Faro airport, you couldn't be anymore conveniently placed. Whether you're looking for a retirement home, holiday home, to relocate or quite simply wanting to make an extra income through rental investments, no need to look any further. This is the one for you! Tavira is one of the oldest Moorish towns in Eastern Algarve, concealing a charismatic heritage until this day, becoming one of the finest resort towns in the area. The town extends along the river banks of Gilão, where Moorish influences beautifully compliments de deep-rooted Portuguese traditional culture. Explore the magnificent buildings and historic churches along the river through the cobbled streets, take a taxi-boat and dive into the Caribbean-Like Islands of Cabanas and Barril located just off the main town. Completion date end of 2019
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"How? Are you pregnant again?" he asked.
"No, no, no! What a sick and twisted mind, you have," I giggled. Then I proceeded to tell my mom and dad what had just transpired.
Earlier that evening, I had noticed a strange sound. At first, I was hard-pressed to identify it, but eventually, I realized it was silence. In a panic, I scrambled about in search of the kids. The baby was fast asleep, but I found the boys feverishly working on a project in the TV room. Heads down, pencils in hand, they were concentrating all their attention on popping scores of holes into the top of a padded leather trunk we use as a toy chest.
As I related this detail to my parents, they broke into ringing peals of laughter, then into hoots, and finally full-fledged tears of delight. You see, they'd had a similar experience many years ago.
When I was four or five, my dad had a Naugahyde recliner, which he prized above all other possessions. One day, I was sitting in the precious chair, clicking away on the button of a ballpoint pen. I was fascinated by the point that popped in and out and in again. Then something neat happened -- the point pushed right through the chair covering -- there was just this little bit of pressure and resistance and then pop!
I must have made a dozen more holes before my mom caught me. In a most uncharacteristic move for my firecracker of a mother, she didn't didn't dish out an immediate whippin'. Instead, she simply said, "Wait until your father gets home," and turned back to the kitchen. I knew I was dead because Mom never waited for Dad to come home. This was serious.
Now, my dad is usually a quiet kind of person when he's happy. But that day, I learned something new about him -- when he's really about to give it to you, he gets quieter still. My dad just talked to me in that calm, level way that does so well. I didn't get spanked or punished. Just the talk that made me want to fall through the floor.
As you can see, this past incident was the reason for their present hilarity.
"So what did you do?" my parents asked, barely constraining their laughter.
"Well," I explained. " I wanted to freak out on them, but there was a nagging little voice in my head that kept asking me 'What did your parents do?' Then I looked at those two little bodies, and I thought, 'Yeah, I've done this.' And when I listened to their explanation about how it started as an accident, but it just felt so good, I thought, 'Uh huh, I know that feeling.' What could I do? I gave them a good talking to, and left it at that." I joked, "Your grandkids are lucky you were merciful to me. That's why you still have them."
This Mother's Day, I'm wondering what other seeds I'm planting in my kids lives. Hopefully, there are seeds of gentleness and kindness, of forgiveness and patience. One day, I'd like to witness huge fields of love, joy, and peace in their lives.
Just for the record, I also wouldn't mind if I walked into their houses and saw a bunch of furniture with poke-holes. :-)
Happy Mother's Day!


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And Cindy Gazecki, cousin of the 2014 Marysville-Pilchuck High School shooting victim, reportedly stated which more than 35 other children have been killed with firearms in the state since that tragedy. She described your situation as 'a public health crisis, an epidemic, also it should be treated as a result.'
What is 'gun violence,' anyway? Is that not the same as 'blunt object' violence or 'fists, feet and hands' violence? Are murder victims any less dead if they are stabbed or poisoned, strangled or bludgeoned, than when they are shot? The term is myopic and misleading, say gun rights activists, who don't differentiate the equipment used in acts of criminal violence.


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The Switch to Digital TV Hits a Snag
Demand for Cheap Converters Is Exceeding Expectations; A Wait List for Coupons
Rattled by the recession, many consumers facing the upcoming switch to digital television are taking the cheap way out -- buying inexpensive converter boxes instead of new digital TV sets. But now, amid higher demand, the government is running out of money to subsidize the purchase of the converters.
As of Monday, consumers who request the $40 government coupons are being put on a waiting list, Commerce Department officials said. The coupons help pay for set-top digital converter boxes that allow older TVs to receive digital...


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Auto suppliers eye effects of industry bailout effort
Some local businesses are keeping a close eye on Washington as the federal government ponders a bailout for the auto industry.
But Bernie Andrews of Regional Economic Development Inc. said Mid-Missouri might be uniquely positioned to weather the forecast economic storm if some or all of the Big Three automakers are forced to declare bankruptcy.
He noted that Columbia has seen a steady drain of auto industry-related jobs over the past two years, meaning a new round of downsizing in Detroit would not be a catastrophic shock to the local economy.
In 2006, Summit Polymers, maker of plastic molded interior trim for dashboard panels and air-conditioning panels, closed its plant at 1550 Boone Industrial Blvd., laying off 190 full- and part-time employees. In 2007, Collins&Aikman, which assembled instrument panels for Chrysler, Saturn and Mitsubishi models, shut its doors on Waco Road, laying off 250 workers.
Officials at the Dana Corp. plant at 2400 LeMone Industrial Blvd. hope the climate will change. The plant, which makes axles for Ford, GM and Nissan, employs 252 people but has laid off more than 100 in the past year. Plant Manager Max Dunlap said Dana recently told 48 more employees they are let go as of tomorrow.
Dunlap said anything that happens to the Big Three will affect Dana - GM accounts for 20 percent of the company's business, and Ford accounts for 70 percent - but he doesn't think bankruptcy will be an endgame.
Hiring freeze not complete; MU finds way to fill jobs
University of Missouri Chancellor Brady Deaton released a plan Tuesday to assess what job openings could be filled despite a systemwide hiring freeze recently announced by UM System President Gary Forsee.
Positions fully funded by grants, endowments, contracts or federal programs, such as student work-study jobs, will be exempt from the freeze, Deaton said. All other open positions that departments hope to fill must be submitted for review by the chancellor's staff. Certain jobs, including those involving public safety or compliance issues or part-time and temporary faculty positions for springtime teaching needs, will be "expeditiously" considered. Other openings will go through a longer review.
Forsee announced the freeze in response to the "unprecedented" national economic situation. He delegated authority to each of the system's four chancellors to make exceptions for critical jobs.
MU Provost Brian Foster said positions will be considered on an individual basis and that there are no jobs other than those automatically exempt that will be automatically filled or left open. "This budgeting and scrutinizing happens all the time," he said. "Now we're just examining everything more closely."
To see the full hiring freeze plan, visit chancellor.missouri.edu/news/hiring-freeze. php.
Although the UM System hiring freeze applies to the MU Athletic Department as a whole, football Coach Gary Pinkel's contract negotiations did not, Deaton said.
Deaton said Pinkel, who yesterday finalized a seven-year contract with the university worth as much as $2.5 million a year, is not a new hire, and his contract negotiation didn't have to go through the same process as filling an open position. Should the athletic department require any new hires, it would have to go through the same review process as other departments on campus, Deaton said.
A-B's Clydesdales make home in Cooper County
Clydesdales, the hoofed symbol of Anheuser-Busch, are out stomping the hillsides of rural Cooper County.
"We're really excited about this facility," said Jim Poole, general manager of Clydesdale operations for A-B. "Maybe at some point in time, we may use the property for shooting some of our commercials. It's such a beautiful area that we'd be remiss if we didn't utilize."
The 350-acre farm, which will be A-B's largest breeding facility in the world, currently is home to 100 Clydesdales, which were trucked in last month from the breeding farm in Menifee, Calif. At full capacity, Poole said, the farm will be home to about 150 horses - 50 "breed mares," five breeding stallions and dozens of younger geldings trained to pull the hitch in front of the brewer's signature red beer wagon.
Poole said the company chose to build the Cooper County facility, which sits on a bluff across the Missouri River from Overton, to be closer to A-B headquarters and bought the land in 2006.
But the beer giant has been highly secretive since that time. Requests for information from news outlets were mostly denied, and locals haven't seen much beyond the two stone gates inscribed with the Busch logo at the entrance facing Highway 98.
For reasons of sanitation and to create a haven of privacy, though, the farm will not be open to the public. It includes 10 pastures, 15 miles of white fence and 34 box stalls for the horses in wintertime. The horses in A-B's signature hitch are bred to exacting specifications. They stand 6 feet at the shoulder, can weigh more than 2,000 pounds and all must be bay in color, have four white stocking feet, a blaze of white on the face and a black mane and tail.
Poole also addressed the simmering question about whether A-B's new corporate owner, InBev, will be inclined to keep the costly symbol. "We certainly hope so," he said.
"Our main motto is: 'Making friends is our business,' and the Clydesdales do make a lot of friends," he said. "People love 'em."
Economist says financial crisis could be nearing end
The worst of the economic crisis is here, and the U.S. economy will begin to stabilize in the first quarter of next year, economist Brian Wesbury predicted this week at the fifth annual Economic Outlook Conference hosted by the University of Missouri Robert J. Trulaske, Sr. College of Business.
Wesbury, a Columbia native and chief economist for Lisle, Ill.-based First Trust Advisors LP, said increased unemployment claims and weak retail sales last month were the result of a panic that came after the collapse of financial institutions such as Lehman Bros. "This is a panic, not a classic recession," he said. "Panic set in, and people stopped spending."
Wesbury said although that shock caused a drop in monetary velocity - the speed with which money moves through the economy - the Federal Reserve has responded by printing more money, which in the short term will help the situation.
"The classic response to a drop in velocity is for the Fed to print more money, and they're doing it," he said. "I believe this drop in velocity, this panic, is going to be very short-lived."
Wesbury, a Rock Bridge High School graduate, earned a bachelor's degree in economics from the University of Montana and a master's degree in business administration from Northwestern University. He has been called one of the nation's top economic forecasters by The Wall Street Journal and USA Today. He also is economic editor for The American Spectator magazine and a contributor for CNBC.
Although Wesbury said he forecasts that real gross domestic product will contract by about 4 percent this quarter, data show that in October banks increased commercial and industrial lending by more than 4 percent, real estate loans by 3 percent and consumer loans by 2 percent. "Dogs bark, and people spend," he said. "We cannot stay in the panic we've been in for long."


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AS Monaco head coach Leonardo Jardim has vowed not to change his side's attacking football style after beating Borussia Dortmund to reach the Champions League semi-finals.
The Ligue 1 leaders beat Thomas Tuchel's side 3-1 in the quarter-final second leg to secure a 6-3 aggregate win as they scored at least three goals for the fifth consecutive time in the tournament.
"It could have been 5-3 or 6-3 because both teams missed several chances," Jardim is quoted by Sky Sports News as saying. "We knew that they give a lot of space and we took advantage from it. Now, regardless of who we will take on next, we will be facing a very experienced team.
"We played a very solid game, we were in control but we showed ambition. We were always looking for the extra goal, that is the way we play, it is in our DNA. Our rivals will want to draw us [on Friday] but our ambition is to enjoy it and play with our attacking qualities like we always do."
Monaco, whose next fixture is Sunday's league encounter with Lyon, are in the final four of the Champions League alongside Real Madrid, Atletico Madrid, and Juventus.


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Post a Job
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ct | KFC Team Member in Mebane, NC
KFC Team Member
$20,010.00 - 28,030.00 / Year *
5202 Mrs White Ln
Mebane, NC 27302
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KFC - JobID: e307eb3a-ab28-4a4b-bc08-a752013a4adc [Crew Member / Restaurant Associate / Server / Cashier] Key responsibilities include customer service in the restaurant or drive-thru, taking and ringing up orders, handling payment and thanking customers. You'll also prepare and store food ingredients, assemble food and beverage orders, check to make sure they're correct, package products, and maintain a clean, safe work and dining environment...Join the KFC Family Today >>
* The salary listed in the header is an estimate based on salary data for similar jobs in the same area. Salary or compensation data found in the job description is accurate.


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Ride a Motorcycle and Be Safe
Ms. Wilmot
English 95
17 May 2012
How to Ride a Motorcycle And Be Safe
Riding motorcycles are dangerous, but fun at the same time. Being able to ride on an open road is fun, when there is light traffic or no traffic at all. The danger that a motorcycle brings is falling, hitting a pot hole at excessive speed or even a rock can cause you to lose control of your motorcycle making it dangerous. The weather can make riding a motorcycle dangerous, making it difficult to control your bike if you do not know what to do. Motorcyclists risk their lives every time we go out for a ride. Wearing the proper gear, knowing how to operate a motorcycle, and being aware of the road can keep you safe. Knowing what to wear or how to dress for the weather is the first thing that you do before preparing yourself for a ride on a pleasant day. Protective gear has several purposes, including providing comfort, increasing visibility, and offering protection. When purchasing motorcycle gear, make sure any piece is protective, flexible, breathable and comfortable. When choosing to a helmet, the key is to make sure it is secure but not too tight, or otherwise it may cause headaches. Make sure you buy a helmet that is DOD certified. Be sure to have eye protection so that your eyes will be safe from any debris from the road or keep your eyes from getting too dry from the wind. Gloves are option but they help keep your hands warm. The jacket is also an important part, because it keeps you warm in cold riding situation, your arms are protective, and your torso is protective. Make sure you wear a jacket with a zipper because it is less wind resistance. The most important about thing about motorcycle protective gear, is that nothing should be hanging down loose that could flap in the wind or get caught in the bike. There are several basic controls that you should become familiar with. On the left handlebar is the clutch lever. Mounted on the right handlebar...
Please join StudyMode to read the full document


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Nina Elcao & Neely Shamam - Dating BloggersApril 12, 2015 Korney & White
If you like your podcasts sassy and full of awkward stories, then you're in for a treat this week! Joining us are dating bloggers Nina Elcao and Neely Shamam. Nina, creator of ohheynina.com, sheds light on why she rants about relationships to the internets via a blunt advice column for men and women alike. Neely, creator of One-Thousand First Dates (http://one-thousandfirstdates.tumblr.com/), tells an epic tale about finding love/creepers in the wide world of the web. NOTE: Aron's love life is perfect and there's nothing to discuss.


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More About Us
Our highly qualified, dedicated, young but vibrant professionals, whose passion has kept the brand in a successful lead over the past 8 years in the region is the biological framework for our existence. Our events are grouped in 3 categories; namely, Major Events – guest expectation – 1000 to 10,000. Middle class events – guest expectation – 500 to 1000; Minor event – guest expectation – 10 to 500.
What We Do
1. Provide event management and consultancy services to clients.
2. Provide brand promotion and advertisement services.
3. Production of all kinds of entertainment and event
4. Artist Management
5. Production of Music Video and Documentary services
6. Graphic / Web Designing and Motion Animation Services
At J Black Code we believe in partnerships and collaborations. Opportunities abound for individuals, organizations and benevolent societies looking for investment prospects and/or where to invest for high returns within a fiscal year. Our wide range of investment opportunities include; advertisement, talent management, agro business, ICT, and events to mention a few.
Check out some of our Upcoming Programmes
Keep in touch. Meet us and start a great collaboration.
I humbly welcome you to the Official Site of JBlack Code Events. Feel free to contact us for any info. Thanks!


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again a nice one, Venuslove and romance -- hmmm, you seem to be in a good mood, Venus :))wishes, devika
Life is full of white and red roses. :)
so wat happens when d 2 r mixed??
There's no doubt that God whispered His perfection to us through the flowers. Thank you for your prayer against Abortion. I hope everyone would think this way.
Nice one


text: Seller: mhn_sale (807) 100%, Location: london, Essex, Ships to: GB & many other countries, Item: 162898027988 PLASTIC VEST CARRIER BAGS WHITE *ALL SIZES* - SUPERMARKETS STALLS SHOPS Product Type: Strong Plastic vest carrier bags, available in following sizes / colours:White - 10x15x18", 8mu thick - these are small light duty bags, ideal for confectionery etc.White - 11x17x21", 18mu thick - these are used in supermarkets, grocery stores etc.Blue - 11x17x21", 18mu thick - these are used in supermarkets, grocery stores etcDescription: A multi listing for plastic vest carrier bags. These carrier bags are available in all the sizes listed in the drop down menu above, and in all different pack quantities.Quantity: Choose the number of carrier bags you would like from the drop down menu above. They all come 'split' in sub-packs of 100.Colour: Choose your colour in drop down above (white or blue bags are available)Common Usage: As above Condition: New, Modified Item: No, Custom Bundle: No, Type: Plastic, MPN: Does Not Apply, Brand: Unbranded/Generic, Non-Domestic Product: No


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Search Engines Urls
Budget $30-100 USD
What I'm looking for is the search engines post/get data URLs. What is that? When you fill any forms on any site, and after you click submit, a URL request is made to the server with the form info. Those are the URLs I am looking for. You must include if the method used was POST or GET. These URLs can be to any search engines(popular se's must be in there), directories, blogs, etc. I need about 200 or more( please post the amount you can get ) They must be free to submit and require no email confirmation...meaning the submitter shouldn't have to click on the link(link that is sent to your email) in order for the site to be indexed. They must include arguments according to this:
[[[email]]] = email of the submitter
[[[url]]] = url of the site being added.
[[[fname]]] = first name of the submitter
[[[lname]]] = last name of the submitter
[[[fname]]] = first and last name of the submitter
[[[company]]] = company of the submitter
[[[keywords]]] = keywords of the site
[[[desc]]] = description of the site
[[[username]]] = username (some se require submitter to register. Very rarely will this be needed)
[[[password]]] = password (some se require submitter to register. Very rarely will this be needed)
[[[comments]]] = extra comments by the submitter
[[[meta]]] = meta tag of the site
[[[title]]] = title of the site
[[[hitsday]]] = daily hits to the site
[[[hitsmonth]]] = monthly hits to the site
[[[hitsyear]]] = yearly hits to the site
[[[address]]] = home address of the submitter (very rarely will this be needed)
[[[phone]]] = phone number of the submitter (very rarely will this be needed)
[[[fax]]] = fax number of the submitter (very rarely will this be needed)
[[[city]]] = city of where the submitter lives in
[[[state]]] = state of where the submitter lives in
[[[zip]]] = zip code of where the submitter lives
[[[country]]] - shortcut of country (examples: US, UK, FR..)
[[[country1]]] - the long name (example: United States Of America, England, France)
you can add any other arguments that a search engine requires as long as you leave me a good description of that added argument.
Some Finished Examples:
-((POST))[url removed, login to view][[[url]]]&submit_contact__email=[[[email]]]&B1=Submit URL
-((POST))[url removed, login to view][[[url]]]&Email=[[[email]]]&Submit URL&Clear Form
-((GET))[url removed, login to view];country=WorldWide&name=URL Submitter&url=[[[url]]]&email=[[[email]]]&title=[[[title]]]&keywords=[[[keywords]]]
Additional Info (Added 4/13/2005 at 17:54 EST)...
I know i made the description long but even a 10 year old can do it onces he knows what he supose to do (thats why i posted it in much detail.)
Still have questions? contact me please
these three urls will help you very much.
[url removed, login to view]
[url removed, login to view]
[url removed, login to view]
note, im not asking you to sumit...all im asking you is to make the url. If the url askes for an email, replace the value with [[[email]]]. If it askes for the url of the site, replace it with [[[url]]] ...all the agruments are above....hope this clears things up.
Décerné à:
We can give you immediately 200 working urls as specified.
10 freelance font une offre moyenne de $68 pour ce travail
Hi Thanks for so nice and gentle elaboration. And it shows your class. It shows how polite you are . Thanks for that We need to talk to you. would you mind to do that . Please visit PMB. Regards ASg. for ZIG Plus
Please See PMB.
i have understood ver well waht u want and can provide u the MAXIMUM work
Hello sir, I can provide 200 url's for US $40 i.e. 100 for USD 20 Please let me know the number of url's you need via PMB
Hi i can provide you 100 url for 15 $. 200 for 28$ 300 for 36$ and so on... Marco Troise
I will provide you the 200 urls you r searching for!! Last but not least"Trust me for good results!!! Thx Regards Arun
I can easily do it for you. Please see your PMB.
hiya....my bid for your project is 35$ for every 100 URL's...i.e. if u want only 100 url's it will be 35$...if u want 200 url's it will be 70$ etc.... willing to negotiate if you provide me projects with long term.. Plus
Hello, This one is pretty easy to do in a custom text editor that I own. It shouldnt take more than a day. Since I have not worked on this portal before I could send you a sample of say 25 to give you an estimat Plus


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- Sample come go with me
- Sample ghosts rider in the sky
- Sample ring of fire
- Sample demo
- Sample elvis mix
Los Angeles Country Singer 1
You may think you are just going to get country when you book this Los Angeles Country Singer for an event. But hold onto your cowboy hat because you're about to go on a musical grand tour! Whether performing as a solo act or with his band, hey takes you on a nostalgic trip through memorable country, with frequent detours to classic rock of the 50's, 60's, and 70's ("PeggySue", "Country Roads", "Sundown"), then onto some refreshingly fun jaunts with impersonations of Willie Nelson, Waylon Jennings, Johnny Cash, and Elvis Presley. Throughout your journey, this artist keeps you close with lots of audience participation and humorous dialogue, and will throw in some surprises with a few of his original songs from his latest CD.
Los Angeles Country Singer awards
Country Music Associations of America - Entertainer of the Year
California Country Music Association - Golden Eagle Award
California Country Music Association - Video of the Year
California Country Music Association - Male Vocalist of the Year
Royal Records - Outstanding Performer Award
This Los Angeles Country Singer began his career in 1971 and has been delighting audiences all around the country ever since. From Las Vegas to Arkansas, to Honolulu to Arizona, New York to California. His music brings something to the picnic for any venue, any occasion. He performs at Desert Adventures in Indio and has played at the Orange County Fair for 12 years, in addition to regular appearances at Knott's Berry Farm since 1990. At the Great North American Country Music Festival in South Dakota, This Los Angeles Country Singer performed with fellow musicians Roy Orbison, the Everly Brothers and the Bellamy Brothers, just to name a few. He has also toured internationally. Including Sweden and Germany. He also lends his name and talent to support many charities and participates and performs in various celebrity golf tournaments.
The charity work is very important to this Los Angeles Country Singer because he says, "Being able to create music and make a living from this is incredibly rewarding. I need to give it back when it is needed to help other people. I will bring my guitar anytime you want to create some smiles and have some fun. I feel I have been blessed."
Los Angeles Country Singer venues
Morongo Casino in Cabazon California
Stuart's Steakhouse in Palm Springs California
Agua Caliente Casino in Rancho Mirage California Desert
Diamond Casino in Tucson Arizona
Chumash Casino in Santa Barbara California
Edgewater Casino in Laughlin Nevada
Flamingo Casino in Laughlin Nevada
Fantasy Springs Casino Indio California
Golden Nugget Casino in Reno Nevada


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Manufacturers: -IWill USA -Matrox -Samsung USA -Crucial -Toshiba -Actiontec -M-audio -EverGreen Tech -EPI USA -Buffalo Tech -ThermalTake -Zalman Tech -Cyber Cooler -Vantec USA -Evercool -Chenbro -CoolerMaster -C3 -SuperPower -Lian Li -2CoolPC -Icemat -TweakMonster -Cobalt3 -Sunbeam -ShatteredWeb -Tagan -Rosewill -EDGE Memory -Eagle Tech Online Shops: -CrazyPC -HighSpeed PC -UmaxPC -Xoxide Mods -Directron -Azzo -Computer Geeks -CensusPC
LapLogic Aerogel ExtremeEDGE DiskGO 160GB Network HDDGelaSkins for DS and PSP
Again, we don't condone under-aged drinking and so forth. This was a guide created by a few older folks who just had a little too much...time on their hand.
LapLogic G800/W800 Aerogel Extreme
Mahogany USB Drive
EDGE DiskGO 160GBNetwork HDD
GelaSkinsDS and PSP


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It's the week for orange and black so be prepared for some Halloween goodies this week (and maybe a little Christmas thrown in as well).
This week we are creating Halloween cards at Corrosive Challenges. If you aren't all about Halloween, then create something using orange and black. Here is my sample:
I know someone who celebrates a Halloween anniversary so I thought this image from Tiddly Inks would be perfect! Add a little orange, green and purple, and you've got a not-so-spooky greeting!
Keeping this short and sweet today - come join in the fun this week at Corrosive! We'd love to see your terrifyingly terrific Halloween treats!
Back tomorrow with two posts!
Favorite Things: January 2019
1 day ago


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Gene regulation – The advent of high throughput techniques for studying translation in conjunction with transcription have opened up for studying gene regulation in an integrative manner. We combine high-throughput analysis of transcription (e.g. RNA-Seq, CAGE) and translation (ribosome profiling) to build models of regulation during early embryogenesis.
Non-coding RNAs and pervasive translation – In addition to elucidating translational regulation, ribosome profiling has also revealed that translation is a far more pervasive process than previously thought taking place over 5′ leaders, 3′ trailers and transcripts annotated as non-coding. In our lab we are investigating this phenomenon and which, if any, function it has.
Genome engineering – the development of the CRISPR/Cas9 system has in many ways revolutionized genome engineering. We develop tools to facilitate the process of designing optimal guide RNAs for targeting loci and analyzing the resulting cuts through high-throughput sequencing.
Ancient epigenetics – A "hobby" project in the lab. Together with Jakob Skou-Pedersen and Orlando Ludovic we created the first nucleosome map of an ancient genome.


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2019 Best Elementary Schools in West BroadAbout this List
Lockeland Elementary School - Design Center
117 Best Public Elementary Schools in Tennessee
- Metro Nashville Public Schools, TN
- 2
Alum: I had a pretty good experience at this school. when ever I was having trouble reading and writing there were plenty of teachers that helped me after school so that I would not be behind . I really appreciated that and I will as ways remember the wonderful staff at Lockeland. When I attended Lockeland there was a lot of diversity but it is not as much now. One thing that I would like to see is a lot more diversity.
- 297 Students
- 15:1 Student-Teacher Ratio
Cora Howe School
- Metro Nashville Public Schools, TN
- 3
Niche User: This school has students with a range of disabilities. The program is established to help the student with disabilities learn at the pace that is appropriate for them. The staff and families all work together with outside agencies to provide the students with all the services they need throughout the school year.
- 104 Students
- 4:1 Student-Teacher Ratio


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1. How to fill the online registration form on shaadmaani.com ?
Go to the online registration form. Fill out the required (marked * symbol) information as accurately and click on the Register button. We will send your user id and password to your email id, and you will become a Registered member of shaadmaani.com . It is absolutely FREE of cost!
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8 July 1883 to 27 March 1918
War Service:
Second Lieutenant ALLEN CLAUDE MORRISON POWNALL of 'B' Battery, 104 Brigade, Royal Field Artillery was killed in action on 27 March 1918. He joined the West Kent Yeomanry in February 1910. He served at Gallipoli in 1915 and was invalided home with enteric fever. He was commissioned into the RFA on 30 July 1917 and went to France two months later.
He is buried and remembered in Fonquevillers Military Cemetery.
Location of Memorial:
He is remembered on the war memorial at the parish church of St Mary, Lewisham.
He was born in Eastbourne on 8 July 1883, the son of Capt. F. G. Pownall (R.A.).and Mrs Margaret Pownall. In later years she moved to Westdown Road, Catford. He was educated at Rother House and the West Kent Grammar School. He worked as a cashier at J Travers & Sons.
de Ruvigny Roll of Honour
Contributed By: Andy Pepper
Do you have more information on this person or the memorial they are commemorated on? If so click here to contribute information.
by Local History and Archives Centre, Lewisham and licensed for reuse under this Creative Commons Licence


text:
One Hand Typing - check it out - Very cool
Daily rants of Trey B. and some select friends, living in Houston TX. Its for his friends, family, co-workers, and those who don't know him but really have nothing better to do. Please leave comments,.. good comments will be added to the posts, and might even get you an guest account to Forknlife.
One Hand Typing - check it out - Very cool
Tech News, Tech Talk, Tech Proud!
Well well,
Heck, Its was October the last time I signed in a ranted a while...


text:
Solar Energy Research Institute, Golden, Colo. 80401
The Electrofluid Dynamic wind-driven generator has been investigated under government supported programs since 1975. The concept features the direct conversion of wind energy into electrical power with virtually no moving parts. Research on this concept has resulted in a detailed operational theory of electrofluid systems and a preliminary conceptual design of a full-scale generator. Analysis of the potential of this concept has established a range for the value indicators and an understanding of its optimization potential and uncertainty. A comparison is made between the value indicators for the Electrofluid Dynamic concept and those of several conventional WECS.
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Three continents at one coffee table. Perugia is an international little city, home to the University for Foreigners, this Umbrian town is at the centre of Italy, among beautiful Appennines. This week it will be home to a Journalism festival, where our founder, Italian journalist Francesco Conte, is participating to …Read More »
Railway station memories in Tata, Hungary
Anna is an English teacher and journalist who was born in Hungary, where she cherishes most of her childhood memories in the small town of Tata. Here, in Tata's railway station, she shares some personal stories about her family house, where her grandfather used to hide citizens of Jewish origin, to help …Read More »
On gender studies and stereotypes
We meet Freijya, Icelandic student living in Budapest, where she graduated in Gender studies. We talk with her about stereotypes and genders. video: Fran AtoposRead More »
The piano player in Boston train station
What a better welcome than some classical music played on a grand piano? Here's the story of a piano player who enjoys giving a warm musical welcome to passengers in Boston train station. Video: Pietro CostanzaRead More »
TerminiTV in Central New Jersey railroad station
It has served as an informal entry point to millions of immigrants, between 1890 and 1950, after their arrival to Ellis island. Central New Jersey railroad station represents much more than trains, it was, for many Europeans seeking refuge in the US, the first piece of land they could set …Read More »
TerminiTV in Paris: Dancing tarantella in Gare du Nord
In Gare du Nord, Paris, we meet two Italians, Tullia and Mattia, who moved to Paris, where they teach "tarantella" dance. Talking of migration, here are some statistics about immigration and migration, to and from Italy. The trend is clear: immigration is decreasing, compared to migration from Italy. There is …Read More »
Paris stories: Abdel, the wheelchair and the reason to go to France
Abdelghani is an IT expert in Paris, he was born in Algeria, but soon after he had polio he ended up on a wheelchair, and living in France. Video: Fran AtoposRead More »
From Lisbon: Love in Italy, life in Portugal, memory in Brazil
Laura is a Brazilian living in Lisbon, Portugal, after spending some time in Paris and Bologna. Welcome to the 21st century, where we're all migrants, one way or another. Video by Valeria Rotili, from Santa Apolonia train station, Lisbon.Read More »
The blue angel of Termini
"I am an angel. I fly through the metro, under the street", says Tiziana, Sicilian born traveler, or rather adventurer. "I squatted all my life, and I'm not ashamed of my body. Yesterday we had sex in three, it was beautiful. You want to see my body?" She goes around …Read More »
A year of Termini TV _ handcraft life stories
Timelapse in Termini: one year ago precisely we pressed REC for the first time. Here's a timelapse of the best interviews in Termini train station, in Rome. After one year of work, we can already count on a weekly collaboration with "Internazionale" (and soon other online magazines) and also we're …Read More »


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The quality of the craftsmanship is as beautiful as the chair itself.
Monday, March 28, 2011
Video: The Making of the Eames Lounge Chair
Posted by Myron Smith at 5:25 PM
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This blog is intended to serve as a repository for issues related to Design and a forum for this designer to share his perspective on the factors that have and are shaping the profession. . . Contact: email@example.com


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The Destination Nuptials Of Austinites Melissa Dieck and Gaines Thaxton
By Lance Avery Morgan
Photography by RO Del Río Photography
Melissa Aida Dieck, daughter of Aida and Dr. John Dieck of Austin, and Gaines Edward Thaxton, son of James and Carol Thaxton of Corpus Christi, were married in an enchanting ceremony held at the glamorous Nizuc Resort and Spa in Cancun, Mexico, surrounded by family and friends. After dating for two years, the groom popped the question, amidst much planning, in the beautiful white chapel at the Pueblito of the Mayakoba Resorts they visited under the guise of seeing an artist installation.
The Dieck family, who love Mexico and were happy to share its vast beauty, wanted their guests from around the world to feel welcome as soon as they arrived on Thursday. Transportation was waiting for the guests at the airport to whisk them away where later that evening, the welcome party on the beach with a Mayan theme kicked off the weekend's festivities with a local band, light fare, and cocktails. Plus, gift bags containing personalized details and thoughtful essentials were provided by the bride's aunt and cousin.
On Friday, the bride-to-be, along with her two sisters, Sofia and Alexandra, who were also the maids of honor, and her mother hosted a bridesmaids' luncheon where guests were presented with a Lexicon of Style scarf, a personally designed wedding gift created by the bride's sister, Alexandra. The beach-themed rehearsal dinner was hosted by the groom's parents for the bridal party. In fact, the groom's mother meticulously designed the event, personally making the center piece flower arrangements, hand-painted maracas and tequila shot glasses with the couple's duogram. Afterward, the groom's parents and their family friends hosted a cocktail and dessert party for all guests. On Saturday morning, the bridesmaids joined the bride at her suite where they enjoyed brunch, the view and the pool as they dressed for the nuptials ahead.
The ceremony, filled with Mexican and Catholic traditions, was held in Capilla Xoximilco, a charming destination location near Cancun. The outdoor and natural elements were important to the bride and groom, while sharing the area's Mexican spirit, beauty and soul with a modern take on its rituals and traditions was also important to the bride and her family. Guests strode down the cobblestone walkway to the chapel that was covered with a bed of white rose petals and palm fronds and every detail was beautifully executed by wedding planner Lorena Armengual of Celebración. The bride, wearing a Naeem Khan gown and adorned with custom vintage earrings, arrived with her father by trajinera (a gondola-like flat bottom boat) to the surprise of the groom and the attendees. The ceremony was full of Mexican traditions, and the family priest Father Bud Roland officiated and closed the nuptials in Spanish. The couple was accompanied by bride's maids of honor Alexandra Dieck and Sofia Dieck, and the groom's attendants Jacob Mize and Josh Mintz.
After the ceremony, the guests were transported to an open, beautifully decorated courtyard, where they were greeted by Mariachis and the couple's signature drinks, setting the tone as an elegant al fresco prelude to the dinner reception. The dinner and reception, incorporating the weekend's color theme of beachy black, white, gold and emerald green, were held next door in the Nizuc Conference Center that overlooked the lagoon and the surrounding ecosystem of protected mangroves. As the guests were guided to the dinner and reception venue, they were met by photographs of the couple's passed grandparents as a reminder of their families' legacy and their future. They also found a hand-painted screen indicating their table locations before proceeding up the candlelit stairs to enjoy the sumptuous dinner that was highlighted by toasts and lit by fireworks overhead.
The bride's cake was a one-of-a-kind pisco and almond praline with chocolate ganache filling and was topped with hand-crafted orchids and fondant in golden hues. The groom's cake was red velvet with a soft extra bitter cocoa creamy stuffing and a hint of Papantla vanilla, decorated with edible 23K gold leaf. Both were created by Chef Nicolas Oviedo with the bride involved in every detail.
The Social band, flown in from Miami, entertained during dinner and provided the music and energy for the guests to dance the night away. To transition to the after party, the bride and groom were sent off by the guests with an array of sparklers as the guests were transferred to it in golf carts to La Punta, an outdoor venue with a DJ, cigar bar, lighted Mexican taco stand, along with Mexican and Middle Eastern desserts. A member of the band became the DJ and the party wrapped after 3:00 am. The next morning the guests were bid bon-voyage with a farewell brunch hosted by bride's parents and family friends.
Following the spectacular wedding weekend filled with family, friends, and festivities, the newlyweds knew they wanted a relaxing honeymoon destination. They will soon depart for a beach trip to Bora Bora. The couple now resides in Austin, where the bride is a realtor with Roxan Coffman Properties, and the groom is in the oil and gas business with Thaxton Consulting Services. They enjoy live music, traveling, and adventures around town and the globe.


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This simle, elegant and dynamic project is ideal for presentation of your press, blog, website, slogan, ideas or short mesage. You can use it like logo reveal or intro animation. Add your logo, images or videos for cool feeling, rewrite web and you are redy to render.
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(Disclaimer: I apologize for the geeked out title of this post, but with this non-stop winter weather we are experiencing, I think I'm about to go nuts! 🙂 )
Can you believe that Easter is this weekend? It must be the weather (or how awesomely busy we've been!), as I am behind and not quite ready for the big weekend. Easter means something very special and sacred to us at Social Graces. On top of that, it gives us another reason for DIY-ing and crafting.
In case you are behind, like me, and need something to spark your creative side, I am here to share a few unique Easter egg ideas we've come across lately:
How are you decorating your eggs this year?


text: Hi there, here's the trouble: I always had display language for my windows 7 set for english and non-unicode (the one in region and language->locale) set for russian. But now i ran into a program that needs locale option set for english to work, but if I do that I get all russian text in txt files as ???????? So is there a way I can set locale option for english and still view russian as i did before? Simply installing russian language pack for display didnt help. And also what do people do if they have non-unicode programs in different languages? switch locale option all the time for needed one?


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Abnormal blood pressure is one of the most common conditions in the world. As the name implies it refers to mount of pressure with which blood is circulating in the arteries of your body. Blood pressure should not be very high as it will cause severe damage to you veins and body which in result can cause death and it should not be very low either as that too can give rise to diseases.
Blood pressure should remain at specific value which is considered as a normal level. The measurement of blood pressure is divided in two categories commonly known as systolic and diastolic.
Systolic refers to that blood pressure when the heart is pumping blood and diastolic refers to the blood pressure when the heart is idle between the beats of the heart. Blood pressure is measured by using specific medical equipment and the unit in which it is measured is millimeters of mercury (mmHg).
Normally the systolic blood pressure should be less than a reading of 120mmHg while the diastolic blood pressure should be less than a reading of 80mmHg in adults. Mostly the systolic blood pressure is considered to be more significant.
A third of adult in the U.S has a problem of high blood pressure. As the blood pressure rises it can create a more alarming situation for you. No one should take abnormal blood pressure lightly. You should pay a visit to your doctor for a checkup after every two weeks if you happen to suffer from higher or low blood pressure.
If you are worried about abnormal blood pressure and taking medicine than you would be glad to know that there are numerous ways to balance and maintain your blood pressure.
Abnormal blood pressure can be treated easily through the right methods. You just need to make some amendments in your lifestyle to overcome it. The first and foremost step in order to balance your blood pressure is to do exercise regularly.
Don't worry if you are not a fan of going to the gym as by exercising it doesn't mean that you have to go to gym and drink loads of protein shakes. Just a little bit of cardio will be enough do the trick.
If you have high blood pressure, which is also known as the term hypertension or HBP, then exercise can do a lot of good for you. HBP is also named known as a "silent killer". Exercising will not only lower you blood pressure to safer levels but it will also improve the circulation of blood throughout the body. These exercises can include running, jogging, walking and swimming but one should be consistent in these exercise. A regular session of 30 minutes can prove to be very fruitful for and you will surely feel a drastic and vital improvement in yourself.
Losing Extra weight
Blood pressure and weight are directly proportional to some extent. This means that your blood pressure increases with an increase in your weight. Being overweight also causes problems in the respiratory system and you will feel a problem in breathing which in result causes the blood pressure to rise. Losing extra weight is an optimal and appropriate solution to deal with rising blood pressure because losing weight will allow your blood pressure to be more stable.
Healthy and Fruitful Diet
A natural remedy to control and stabilize your blood pressure is to take a healthy diet. There is nothing more natural than fruits and vegetables which can help you overcome bad blood pressure. These fruits and vegetable does not only balance your blood pressure but they will also help you control your cholesterol and lower risk of other diseases.
Less Consumption of sodium
Another effective way to stabilize your blood pressure is to reduce the daily intake of sodium. We can reduce the consumption of sodium by using very less amount of salt as it contains a major portion of sodium. According to the experts that one can reduce blood pressure by 8 mmHg just by cutting off the salt in their diet.
Regular Monitoring
Don't forget to regularly monitor your blood pressure in order to ensure that you're on the right track and your blood pressure is stabilized.


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Dedicated to achieve high quality production, we manufacture a wide range of Inline Linear Actuator. We design this actuator using fine quality components and materials as per industrial standards. The inline actuators are capable of lifting, raising, lowering, pushing and pulling loads at fastest speed with higher stroke lengths. The product is also equipped with circuit protection (over-current), which means when the actuator is overloaded it can stop automatically. Available in different specification, this, Inline Linear Actuator can be customized to meet the varied needs of the clients'.
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text: We were discussing in another thread, the possibilities of collaborating with people around the world on a video project. I thought about a series of short narratives that are linked by one single object that would appear in each of our own videos. For example, something like a camera, or something as trivial as a matchstick. If we all had one similarity it would bind them all together. That's just an idea, i think it would be a great thing and the outcome would be something we could all enjoy, we would all get a slice of someone else's imagination! Any other idea's out there? I thought this should have it's own thread, and it's own title, so it's open to whoever is interested. Rich.


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AlumKnight, now a soldier, visits alma mater
28 Sep 2016
- By Bryan Manabat - email@example.com - Variety News Staff
WHILE back on island, Mount Carmel School graduate U.S. Army PFC Joseph Attao spent some time with seniors at his alma mater on Monday.
Attao shared some of his experiences in the military, from boot camp to active duty. He also answered questions regarding military service, his motivations and whether it had been difficult to adjust from civilian to military life.
Attao joined the military in Feb. 2016.
"Honestly, I was not thinking of going into military service after high school," he said.
"U.S. Army human resource specialist, Julian Reyes, my friend, gave me information on what to expect in the service, and after that I just went for it."
Attao is with U.S. Army, 3rd Brigade, 101st Airborne, Calvary Scout, 19th Delta based in Fort Campbell, Kentucky.
"I'm about to get deployed," he told Variety. He will be heading to Kosovo after his vacation.
Attao said he feels good visiting his home island and talking to Mount Carmel School officials, teachers and students.
"The president of MCS, Mr. G, is the one who pushed me to strive hard," he said referring to Galvin Deleon Guerrero.
"Coming back here talking to everyone makes me feel like I'm giving back to those who gave me the motivation to go through everything. Everything starts with that little push — that little push can do so much in a person's life."
Asked if he would recommend military service to high school students, Attao said: "Yes, I would. The Army does so much for you, it changes your life, and it makes you a better person. They offer so much. The Army will teach you real life and morals."
Mount Carmel School is proud of its AlumnKnights, said MCS president Galvin Deleon Guerrero.
"I'm particularly very proud of Mr. Attao. He really has come a long way and overcame a lot to become a man of character and integrity.
"I'm honored that he took time out of his very limited vacation which he could be spending with his family and friends, to come back here to be with our students."
Mount Carmel School, Deleon Guerrero said, offers its senior high students "Knight seminars."
"Basically, these seminars help students prepare for life after high school. We cover college admission, financial literacy, work readiness, and career options, and [Attao's visit is] kind of an extension of that."


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Benefits of Acupuncture
Regardless if you are in your 1st, 2nd, or 3rd trimester acupuncture can be beneficial in many ways. Acupuncture is safe and gentle during pregnancy. Studies and clinical data suggest that acupuncture can shorten the length of labor and reduce the need for medical interventions like epidural pain relief, artificial labor induction, and cesarean section.
The following is a list of the issues we address specifically during and after pregnancy.


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Isidorine A. (Schopper) Gautriaud
b. July 26, 1856, France
d. Oct. 10, 1905, Los Angeles, Calif.
w/o Pierre (Pete) Gautriaud
Site B/15/41
Citizens Cemetery records & plot map /Death Notice: Ariz. Daily Journal-Miner, Oct. 15, 1905
Contributed on 5/30/04 by jlwight
Email This Contributor
Record #: 6679
On this site you can upload gravestone photos, locate ancestors and perform genealogy research. If you have a relative buried in Arizona, we encourage you to upload a digital image using our Submit a Photo page. Contributing to this genealogy archive helps family historians and genealogy researchers locate their relatives and complete their family tree.
Submitted: 5/30/04 • Approved: 1/10/19 • Last Updated: 1/13/19 • R6679-G6679-S3


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Pink Friday in Warwick — Photos!
The First Annual Pink Friday in Warwick, on Saturday, October 19th, was a success in spite of the weather. The many people who braved the rain enjoyed a wide range of events, from promotions and "freebies" provided by participating shops and restaurants, to makeovers by local beauty salons, to dance and fitness exhibitions, and even a DJ!
In the photo, Pink Friday coordinator Tim Mullally presents a ceremonial check for $1500 to Miles of Hope Founder Dana Effron and Executive Director Pari Forood, a gift from the Warwick Merchants Guild. Shops and restaurants that participated in Pink Friday will be donating a percentage of the day's proceeds to Miles of Hope.
Click to read Warwick Advertiser article, with photos.
Pink Friday was presented by the Warwick Merchants Guild and Miles of Hope, and sponsored by the Bon Secours Charity Health System.


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30 Apr 2015 #31
Lol, I accidentaly came here and I can't believe what you guys are saying.
First of all, term ,,,terrorist'' desribes person who is fighting against a legal government. Austro-Hungarian government in Balkan was everything but legal. They were mistreating people here and taking away every civil right from them. They were a dictators and I would compare these guys with Hitler. Gavrilo was ready to dye for his country and it's a really questionable what would be happening if he didn't kill Ferdinand.
However, Austrians were just waiting for the least incident to start the war. Conditions in the country already were a similar to the war conditions.
And it doesn't matter who was a Gavrilo's victim, he did what he had to do. He had to kill Ferdinand and his wife was close to him. Loss of Ferdinand's wife was nothing when we compare a Serbian losses.
In short - Gavrilo Princip was a fighter for freedom, fighter against occupiers. I hope God will forgive him for a murders which he had to do and intention to kill himself after that.
Btw, I can't believe that you guys are posting such a negative things against Serbs. Starting with Gavrilo Princip, you are accusing him for killing Ferdinand's woman? Wtf. Talking about the other crimes, yes they existed. And I see that you are talking about Foca crimes. You know, not everyone is perfect in the army. All war criminals from Serbia were accused and they are sitting in the jail atm. Serbs were making a crimes during the war, but not just them. Everyone were doing it and just Serbian people are in jail for it.
90's war : Ante Gotovina and Croatians, Haradinaj and Kosovo Albanians(war criminals from UCK are even sitting in ,,the Kosovo governement'' atm, chatting with Obama and fellas), Bosnian mujahedeen, etc. ; none of them is in jail.
WW1 and 2 - Serbian losses were huge, almost 2 milion people got killed. Ante Pavelic killed smt like more than 1 milion Serbs, Jews and others,, in overall. And still, nobody from his army wasn't punished. Croatians are even denying war crimes and existance of Jasenovac camp.