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SOURCE: Sermonix Pharmaceuticals LLC
August 03, 2016 10:59 ET
COLUMBUS, OH--(Marketwired - Aug 3, 2016) - Sermonix Pharmaceuticals LLC, a specialty pharmaceutical company focused on late-stage women's health products, convened the inaugural meeting of its Oncology Steering Committee July 14th in New York City. The group, which included world-renowned experts focused on the prevention, diagnosis and treatment of breast cancer, discussed the utility of Sermonix's lead investigational drug, lasofoxifene, in breast cancer treatment and survivorship.
"Sermonix is engaging with some of the leading experts in the management of breast cancer patients and survivors, and the input we received at our meeting was invaluable," said Dr. David Portman, Chief Executive Officer and Chief Medical Officer of Sermonix. "Sermonix looks forward to contributing to this important therapeutic area and exploring other uses for lasofoxifene in the oncology space with the ongoing guidance from this esteemed group of researchers and clinicians."
Lasofoxifene, a third-generation selective estrogen receptor modulator (SERM), is one of the most well-studied drugs in its category. It has been evaluated in more than 15,000 women in a comprehensive worldwide phase I-III clinical development program that includes the PEARL, OPAL and other trials, showing a positive impact on vulvovaginal atrophy (VVA) in addition to a reduction in the risk of vertebral and non-vertebral fractures.
With breast cancer treatment routinely involving use of aromatase inhibitors that block estrogen production, side effects for survivors frequently include VVA and osteoporosis. These issues are increasing as survival rates rise and women live longer than ever post-breast cancer treatment.
"There is an unmet need for therapies that can address common genitourinary symptoms of breast cancer survivors," said steering committee member Dr. Michael Krychman, Executive Director of the Southern California Center for Sexual Health and Survivorship Medicine in Newport Beach, California. "These women suffer disproportionately from severe vulvovaginal atrophy that impacts not only their partner relationships, but also negatively impacts their psychosocial well-being. Many of these women either choose not to or cannot tolerate traditional estrogen therapy since it has a box warning for breast cancer, and as many as 20 percent are non-compliant on aromatase inhibitors due to the side effect profile."
Clinical studies have shown that in women with osteoporosis, lasofoxifene reduced the risk of vertebral fractures by 42 percent and non-vertebral fractures by 24 percent compared to placebo, and reduced estrogen-receptor positive breast cancer by 80 percent. Sermonix plans to seek FDA approval for the use of lasofoxifene to treat several women's health indications, including osteoporosis and symptoms of VVA. Approval in other territories will also be sought.
Dr. Larry Norton, Deputy Physician-in-Chief for Breast Cancer Programs at Memorial Sloan Kettering Cancer Center and a member of the steering committee, stated: "Many breast cancer treatments may have deleterious effects on bones, so there are survivors who, for this reason as well as natural aging, are at increased risk for osteoporosis and consequently osteoporotic fractures. While there are therapies that help in these cases, not everyone benefits and some do not tolerate these therapies well. So there is a need for alternative and additional bone-strengthening medications. Since lasofoxifene may also provide improvement in vulvovaginal atrophy, another common problem in breast cancer survivors, it could be useful in improving their health in several ways."
The Sermonix Oncology Steering Committee members are:
More on lasofoxifene
Lasofoxifene -- a SERM, also known as an estrogen agonist/antagonist -- was originally developed through collaboration between Ligand Pharmaceuticals and Pfizer. Pfizer developed lasofoxifene for osteoporosis. It did not receive FDA approval in 2009; however, in Europe lasofoxifene was approved for osteoporosis treatment by the EMEA that same year. Pfizer never marketed lasofoxifene in Europe and subsequently rights to lasofoxifene reverted to Ligand in 2011. Sermonix obtained licensing rights to oral lasofoxifene from Ligand in February 2015 and is currently pursuing regulatory approval.
About Sermonix
Sermonix Pharmaceuticals LLC is a specialty pharmaceutical company focused on bringing new and emerging late-stage women's health products through clinical development and regulatory approval. Founded in 2014, Sermonix has assembled a considerable management team with success in women's healthcare development. Dr. David Portman, Sermonix's founder and CEO, was principal investigator for the Phase II and Phase III lasofoxifene clinical trials and was actively involved during the drug's clinical development. Dr. Portman has experience in all stages of the regulatory approval process. James Symons, MS, PhD, is Vice President of Clinical Development at Sermonix and was the global clinical lead for the lasofoxifene development program for vulvovaginal atrophy as well as for multiple women's health submissions to the FDA during his tenure at Pfizer. Paul Plourde, Sermonix Oncology Team Leader, was previously with Astra-Zeneca, where he was instrumental in the development and approval of both tamoxifen and Arimidex®. Elizabeth Attias, MMSc, ScD, Vice President of Business Development, has experience in all stages of women's health product assessment, market development, launch and commercialization. Miriam Portman, M.D., is the Chief Operating Officer of Sermonix. She is former Co-director and Founder of the Columbus Center for Women's Health Research and has extensive experience in clinical research, with a focus on FDA regulatory issues, clinical trial conduct, budgets and contracts.
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An update of the MMLs (originally done by Craig Caroon) for various big scenarios that use MML scripts for custom Shapes and Textures. This allows these scenarios to work with the latest builds of Aleph One currently being released for Windows (SDL). Now supports M2 for Windows and M1A1 for SDL v1.5 (latest version makes new Tiny Bobs friendly under the motion sensor). Rubicon should work when properly extracted by Aladdin Expander. "Save Macintosh files in MacBinary format" must be enabled in Aladdin Expander for Windows' Cross-Platform tab under "Preferences".
A Shapes patch and an MML script that allows Return To Marathon to be played with Aleph One.
An example of some 3D modeling and per-level MML scripting for Aleph One.
The four new Tiny Bobs types occupy the VacBob slots in "M1A1 for SDL" Physics. This patch will update the "Settings" MML Script of "M1A1 for SDL" to show the "Assimilated VacBob" Tiny Bob as being friendly under the motion sensor.
If you install Aleph One into your M1A1 folder, you will need to apply this patch to restore the original M1A1 MML Script settings.

subset: commoncrawl


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Do talents affect financial decisions?
Talented workers are the first to leave a firm in financial distress. Simultaneously, this makes recruiting new skilled workers much more difficult. Labor fragility is therefore a key determinant of a firm capital structure: CFOs assess the workforce risk associated with high leverage when deciding to issue debt or equity. This is especially true for companies relying on skilled labor.
How can financing decisions affect the allocation of talent? This is the question Professors Baghai, Silva, Thell and Vig explore in the paper "Talent in Distressed Firms: Investigating the Labor Costs of Financial Distress". Their research shows that among the risks associated with a high level of debt, losing skilled workers is a prominent one.
Such talents being central to the running and development of a firm, can cause their departure to endanger the future of the company. CFOs therefore take this risk into account when making key financial decisions, a result that helps us to understand the determinants of firms' capital structure better.
Who are the first to leave the ship?
To study the link between labor fragility and leverage, the researchers look at very detailed data on Swedish firms and their employees. Their dataset contains the history of employment for all Swedish individuals between 1990 and 2011, as well as the information on wages and socio-economic characteristics. They also collect the results of military enlistment tests, similar to IQ tests, available for Swedish males which give them a proxy for individuals' cognitive ability. Talented workers are defined as Swedish males having scored in the top 5 percent at this test. On the firms' side, they had access to firm-level financial statement and detailed information on bankruptcy filings.
Armed with this comprehensive dataset, they focus on the evolution of Swedish firms' workforce around bankruptcy. The authors find that the most talented workers are 30% more likely to leave compared to the average worker. Meanwhile, the recruitment of talent does not catch up, implying an overall drop in the quality of workers within the firm. They finally confirm all their results using advanced econometric methods as well as specificities of Swedish labor laws.
Despite being intuitive, this result is not at all obvious from a theoretical point of view. On one side, a skilled worker may choose to exit given that it will be easy for them to get a new job. On the other side, a skilled worker may be more patient as they won't have to accept a lower wage from another firm in case of liquidation. Additionally, they could possibly have the access to information that may help them to distinguish between economic and financial distress . This finding thus constitutes a major step towards a better understanding of the dynamics of the labor market.
Firms whose employees are especially skilled are more reluctant to use debt rather than equity financing.
What consequences for firms' financing decisions?
After having established the propensity for skilled workers to leave firms in financial distress, the researchers then ask how such a risk affects firms' financing decisions. Indeed, one of the leading theory of firms' capital structure decision, namely the trade-off theory , is that managers weight the advantages of debt, such as the interest tax shield, with its disadvantage, e.g. bankruptcy costs (legal costs or loss of reputation). In a nutshell, the tradeoff theory argues that CFOs do a risk/benefit analysis when deciding their level of leverage. According to the above presented findings, a high level of leverage also has a cost if it leads to the loss of talents. Thus, this theory predicts that firms that mostly rely on skilled labor (firms in R&D, IT, finance…) should have a lower leverage compared to companies with a less talented workforce.
They have tested this hypothesis both for Swedish and US firms and indeed have found that this is the case. All else being equal, firms whose employees are especially skilled are more reluctant to use debt rather than equity financing. This confirms the predictions of the trade-off theory and deepens our understanding of the determinants of firms' capital structure, one of the most hotly debated subjects in corporate finance.
The authors also look at the interaction between labor fragility, firms' governance and firms' value. They note that labor fragility may have a bright side as it can act as a disciplining device for firms with weak governance mechanism: talent fragility disciplines managers. Looking at a firm's value, they find that the value of firms with poor governance is higher when the mobility of talents is higher, a clear sign that markets understand the governance benefits associated with the threat of losing key employees.
The new economy and human capital
Those findings are especially interesting in light of the development of the "new economy". For high-tech firms relying heavily on R&D, human capital is more important than physical capital. With their value being based on their capacity to innovate constantly, they are highly exposed to the risk of losing talents. Understanding the specificities of the challenges faced by those firms, and their implications for their financial decisions is thus a question of first importance that the authors help to better assess.
This text was written by Charles Boissel, HEC Paris PhD, based on the working paper "Talent in Distressed Firms: Investigating the Labor Costs of Financial Distress" co-authored by Ramin Baghai (Stockholm School of Economics), Rui Silva (London Business School - Department of Finance), Viktor Thell (Stockholm School of Economics), Vikrant Vig (London Business School). This study was presented by Rui Silva during the Adam Smith Conference at HEC Paris on March, 2017.


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Do You Want Vinyl Fence Company in White Oak Texas?
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3. Stop trespassers out
When you have a fence all around your property, you may be confident that trespassers won't have a possibility of the ability to access your home after dark.
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Having a border between you and the world outside, it is possible to enjoy the scenery in the garden without being viewed by people passing by the road.
Regardless of whether you need Vinyl Fence Company or a minor repair, call Longview Fencing for Vinyl Fence Company in White Oak Texas!


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{Review} "13 minutes"
Title: 13 minutes
Author: Sarah Pinborough
Publisher: Gollancz
Pages: 406
I was dead for 13 minutes now I want to know why.
I don't remember how I ended up in the icy water but I do know this: it wasn't an accident.
They say, you should keep your friends close and your enemies closer, but sometimes it's hard to tell them apart.
My friends love me. I know they do.
But that doesn't mean they didn't try to kill me.
My opinion
There is written "Not suitable for younger readers" at the back of the book and I agree that younger readers should really follow this statement. It is all about sex, drugs and attempted murder - the bad side of the society of teenagers. It is a murder mystery which includes the behaviour of teenagers, social media and bullying.
The protagonist is Natasha who is found in the river and doesn't have any memory of what happened before she died for 13 minutes. But she is willing to figure out what happened the day she nearly died. Natasha starts to suspect her closest friends of pulling her into the icy water that evening and asks her ex best friend Becca to help her uncover the truth.
It was thrilling every page. Every paragraph oozes with suspense, every sentence shocked and appalled me more and more, but it was in a kind which didn't let you stop reading but always kept going. I sat at the edge of my seat all the time because there were so many mind games I didn't know. Having read half of the book it seemed like the truth had come out and I kind of expected the twist, but it still surprised me.
The story is composed of diary entries by Natasha, excerpts of some consolations, parts are told in 3rd person, text messages, articles of the newspaper and notes of a policewoman.
The characters were authentic and so simon-pure. Sarah Pinborough cleverly created some teenage girls who depict the situation of growing up. With a few words, she reflects the modern life and contrasts who you are and who you pretend to be.
"Her reaction was so predictable. Everyone is so predictable."I really like this quotation because the bottom line is that this statement isn't unimportant. But I don't want to spoil
Natashas near-death or death-for-13-minutes is the beginning of more! Some strange things happen in the course of this story and there are some surprising twists and turns. The plot is awesome and the ending was just incredible and fantastic.
It's a gripping and shocking story about female friendship and the life of teens.
I give it 5 out of 5 infinities of books.
Yours Ju


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Just Desserts
With the end of the spring sports season, Lake Region athletes were honored last week at the annual Boosters' Club Just Desserts Night.
The following awards were presented:
Principal's Award, given to the student-athlete who achieved an overall grade point average higher than a 90, was a captain of a team and was an all-conference selection: Rachel Wandishin, Kat Merrill, TJ Leach, Alice Sanborn, Wes Sulloway and Nele Haundschild.
LR Boosters Sportsmanship Award: Jacqui Black and Dakota Bush.
Sonya Flanigan Award to the top female athlete: Abby Craffey and Rachel Wandishin.
Steve Gammon Award to the top male athlete: TJ Leach.
Carol Youker Ski Award to: Jacqui Black.
Rick Worthley Golf Award to: Ryan Chute.
Football Scholarship to: Jake Fleck.
Varsity Club Awards
(Selected by Coaches)
Cross-Country running: TJ Leach and Maude Meeker.
Field Hockey: Alice Sanborn.
Football: Ryan Skillern.
Golf: Patrick Hayes.
Boys' Soccer: Dakota Bush.
Girls' Soccer: Rachel Wandishin.
Volleyball: Allison Clark.
Alpine Skiing: Wes Sulloway and Emily Doviak.
Basketball: Alex Hartford and Abby Craffey.
Cheerleading: Stephanie Winslow.
Ice Hockey: Don Kellough.
Indoor Track: Dakota Bush and Hannah Perkins.
Softball: Rachel Wandishin.
Baseball: David Scammon.
Lacrosse: TJ Leach.
Tennis: Wes Sulloway and Kat Merrill.
Outdoor Track: Julia Carlson and Mason Kluge-Edwards.
Varsity Club: Rachel Wandishin, president; Monica Couvillion, Emily Bartlett and Heidi Jewett, vice presidents.
Coach of the Year: Dave Lepage, varsity ice hockey.


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I have been reflecting on the experiences that have helped me to wake up to the preciousness of my own life and I want to share something I wrote a couple of years ago (edited version)
If you have an intention to "wake up" as well, please consider joining me and Maia Duerr for Waking Up to Your Life, a program and learning community we created to support you to begin or deepen a practice.
Application/Registration opens December 17th
Program begins January 15th
photo by Pam Fox
I have been reflecting on how precious and precarious this life is and I am remembering an experience I had several years ago when my friend Gina and I were driving across country from the east coast to the southwest. It was early in the morning and we had just spent the night at a hotel in Wheeling, West Virginia and were heading towards Ohio. We had our tea and snacks for the day, perhaps listening to Krishna Das. Our spirits were up as we continued on our journey, with anticipation, towards Santa Fe. We were on a six lane divided highway, probably going about 65-70 mph and at this point there was little traffic on the road. To our right were woods full of trees moving towards Autumn…the sun was just rising, it was chilly and the air was a bit misty.
Ahead of me I saw something on the highway, and my mind went into high gear as I tried figure out what it was. Everything seemed to be moving in slow motion as I recognized that in the road ahead were a doe and her fawn standing in the middle of the middle lane, the lane my car was in. Instantly I pushed the button to turn on my flashers as I slowed the car way down. I began praying out loud, pleading the doe to lead her fawn out of the road.
At the same time I was noticing there were a number of cars coming up behind us. I was praying that the drivers would see what was happening and would slow down. I recognized that I had absolutely no control of the situation. Where would the deer go? The doe could easily make it over the low concrete divider, but the fawn? And there were cars on the other side of the highway. Please hurry, beautiful mother….please, please, get your precious baby with her little white spots out of the road. My adrenaline was rushing, I could feel my heart beating rapidly, a knot was forming in my stomach, and my eyes were filling with tears…perhaps I was holding my breath. Gina put her hand on my leg. So much was running through my mind. I was terrified that something really awful was about to happen – that the deer and or humans were about to die. Any one of us… all of us.
In a magical, mysterious moment, all the cars slowed down. Somehow the mama deer signaled to her baby and they ran off the highway, disappearing back into the woods. In my mind all the cars came to a complete stop, but I can't say for sure what happened. I was so startled, so awake in that moment… knowing full well that it could have been my last moment, my last breath. But it wasn't.
Another moment of waking up was twenty some years ago when my surgeon, dear Ellen Brock told me that I had cancer, it was as if she had told me I had a cold. My mind could not comprehend the words that came out of her mouth. It wasn't until I saw the tears in her eyes that I recognized it was more serious than a cold.
In that moment, time seemed to leap into slow motion. My adrenaline was rushing, I could feel my heart beating rapidly, a knot was forming in my stomach, and my eyes were filling with tears… perhaps I was holding my breath. Ellen put her hand on my shoulder. So much was running through my mind. I was terrified that something really awful was happening. What did this mean, to have a diagnosis of cancer? How was I going to tell my parents? What was going to happen to my life? Did it mean I was going to die? I was only 31 years old. I don't remember praying or pleading…. The situation was beyond my comprehension and seemingly out of my control. I was in shock, scared and confused. And I was awake.
After a second surgery and chemo treatments I was skin and bones and everything seemed to take way too much energy. I spent the days on the couch, slowly coming to an understanding of what had taken place, and slowly gathering the gifts that were given to me, gifts that continue to guide me to this day. Of course there is so much more to this story (perhaps for another post), but clearly it was not my time to go, for which I am continually amazed, and truly grateful.
I will never forget that moment when a cancer diagnosis crossed my path, nor will I ever forget that moment when the doe and fawn crossed my path. Both took me to an edge. Both were wake up calls. We all have these calls each day – big and small, pushing us to the edge, urging us to awaken and not take things for granted. It seems we somehow need these reminders to wake up. I welcome the small reminders and I recognize that I don't need to wait for a big wake up call to remember how precious this life is and that I can choose to live my life fully…. now. I can choose to wake up.


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HBL Stock Fund
HBL Stock Fund is an open end equity fund managed by HBL Asset Management Limited, a wholly owned subsidiary of HBL.
To provide long term capital growth by investing primarily in a diversified pool of equities and equity related Instruments.
Benefits of Investing in HBL Stock Fund
- Ideal for investors who wish to invest for long term capital growth.
- Minimum Investment: Rs.1,000/=
- Subsequent investment : Rs.1,000/=
- Holding Period: No fixed term; can be redeemed at any time
- Tax Credit: Can be availed by Salaried and self-employed individuals as per current tax laws.
- CGT: Capital Gains Tax will be deducted as per current tax laws.
- Encashment: 2-3 Days. However constitutive documents of the fund allow up to six working days.
- Front end Load: 2.5%
- Risk Level: High


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One of the best tools for your property to gain visibility which Engel & Völkers offers.
The real estate magazine ''Private Residence'' is both printed and digital format with which Engel & Völkers displays some of its extensive catalog of select houses and beautiful apartments to buy. Our customers can access their information through the website of Engel & Völkers, on the ISSUU platform, or find it in printed format in multiple Engel & Völkers offices, such as New York or Barcelona among others, and also in multiple establishments, hotels and waiting rooms for medical consultations of the Principality of Andorra. The magazine has different editions dedicated exclusively to Andorra, having a resounding success.
What can you find in the Private Residence Magazine?
The Private Residence Andorra magazine, is a mobile showcase for the most exclusive properties in the Pyrenees country, from chalets with large stately gardens, to unique mountain ''Borda'' restored and adapted to create charming homes, penthouses and luxury duplexes, and promotions of new developments among others, with the maximum details and the best photographs made by our professionals from the world of the image.
This exclusive tool, caring on detail, and first quality materials, adds to the property that extra point of excellence and refinement, contribution of the values of our brand, the Passion for our properties and our job, the Exclusivity with which we praise your home, and the Competence with which we work for you.
All what Engel & Völkers can offer to you
As one of the most important real estate companies in the world, specializing in residential, commercial, aviation and yacht properties, and with an expert network of more than 9,000 workers in 800 stores distributed across 34 countries on four continents.
Your store in Andorra is located in one of the best areas near Carlemany Avenue where your team of professionals serves Sant Julià de Lòria, Andorra la Vella, Escaldes, Canillo, Ordino, La Massana and Encamp.
If you need to sell, rent or buy real estate, Engel & Völkers Andorra is your ideal partner.
Click here to see the digital issue of the magazine.


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HOUSTON, March 03, 2016 (GLOBE NEWSWIRE) -- Crown Castle International Corp. (NYSE:CCI) ("Crown Castle") announced today that Ben Moreland, Crown Castle's President and Chief Executive Officer, is scheduled to present on Tuesday, March 15, 2016 at 2:55 p.m. Eastern Time at the Citi 2016 Global Property CEO Conference. Mr. Moreland's presentation will be broadcast live over the Internet and is expected to last approximately 35 minutes. The live audio webcast link and presentation for the conference will be available on Crown Castle's website at http://www.crowncastle.com, where it will also be archived for replay.
Crown Castle provides wireless carriers with the infrastructure they need to keep people connected and businesses running. With approximately 40,000 towers and 17,000 small cell nodes supported by approximately 16,000 miles of fiber, Crown Castle is the nation's largest provider of shared wireless infrastructure with a significant presence in the top 100 US markets. For more information on Crown Castle, please visit www.crowncastle.com.
Contacts: Jay Brown, CFO
Son Nguyen, VP - Corporate Finance
Crown Castle International Corp.
Source:Crown Castle International Corp.


text: In my current work, I have my MC going up against an organization, who want the slow destruction of her city (as well as the deaths of all her city leaders). The organization's motive is pretty justified since the MC's city leaders took over the organization's original city, killed it's leaders (which were family members of many members of the organization), and imposed a lot of restrictions and such that changed that city for the worse. Anyway, my great debate is how I should have the MC defeat the villains. By the time the MC reaches them, they've got the MC's city on lockdown, are terrorizing the citizens with a mind-controlled police force, and have already killed one or two of the city leaders. At the very least, MC needs to stop them in order to stop the mind-controlled police and return her city back to some type of normalcy. But I'm really torn between having my MC just kill all of them or finding a way to subdue them (although it'd need to be pretty creative since its about 15 vs 1). Not to mention, I really want to avoid having a villain that's too easy to kill. So now that I've ranted all of that my question to you is: How can I prevent having a too easy villain in this type of scenario? And which method (killing/subduing) would be better?


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10 Tips – How to Find the Best Elder Home Care Services
As an adult child, friend or relative of an aging adult you may be looking into elder home care. Here are ten quick tips to aide you in your search:
1. There are many home care agencies out there. They differ in their ownership structures (Franchise vs. Corporate vs. Private), licensing (differs by state), services and pricing. It is important to find the type of agency that is a good fit for your loved one.
2. Search online for reviews of agencies you are considering. Check out their website, does it look professional and provide up to date information? Do you have any word-of-mouth referrals?
3. Call the agencies you are considering and gather some initial info. Consider the following: Do they answer the phone or return your call timely? Is the representative professional and friendly? Do they ask good questions to help get to know your loved one's needs to match them with an appropriate caregiver?
4. The type of caregiver assigned to your loved one may vary depending on his or her needs (care level). You will want to be informed as to the credentials the caregiver holds. These can vary by state but usually are governed by the Board of Nursing or Health Department.
5. Some agencies use Independent contractors instead of Employees. Why this is important is because of the insurance and tax liabilities. Be sure to ask if the agency Employs, background checks, and insures its caregivers.
6. Pricing will vary based on the needs (care level ), amount of hours and potentially time of day, geographic location, as well as other factors. Be sure to call around and get a feel for the average pricing in your area. You will not want to choose based on price alone, but you do want to know that you are not overpaying for what you receive. You will also want to know if pricing is all-inclusive, or if there are any add-on charges.
7. In most states, licensed agencies are required to maintain a 24-hour emergency call line. Be sure to ask how to get ahold of the agency's management in an off-hours emergency situation.
8. You might be considering 24-hour care for your loved one. If so, consider an agency that provides live-in caregivers. By being charged on a live-in basis, and not hourly, this can be a substantial money saver for you. It also provides added peace of mind that someone is consistently there around the clock for your loved one.
9. Ask for referrals from friends, neighbors, anyone who you know that has used this type of service in the past. If you don't know anyone, consider calling the local Area Agency on Aging, Social Services Office, or even nursing homes for recommendations.
10. Expect and insist upon personal interviews with the potential caregivers that the agency would place with your loved one. You and your loved one may like the agency's administrative personnel and they may give all the right answers, however the caregiver is who will be spending day in and day out with your loved one and you must be comfortable with them.
Are you looking for home care and house calls "near me"? Allegiance Aging Care Services is located at 20 Pidgeon Hill Dr Suite 208, Sterling, VA 20165. This privately-owned home care agency serves the greater Northern Virginia area around the Route 7 corridor. To learn more or for a free consultation, call (703) 539-6029 or contact us through our contact page here. We're nearby, and we're here for you.


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HP announced the release of their third-gen MediaSmart Server EX490 and EX495, soon to arrive in the USA and Europe.
-The new EX495 receives a powerful boost courtesy of an Intel Pentium 2.5 GHZ 64-bit Dual Core Processor, whilst the EX490 gets the Intel Celeron 2.2 GHZ 64-bit Processor (which in itself isn't too sluggish for a home server). The major benefit of the new power plants is faster video conversion, with HP stats declaring 7x faster video conversion than Atom powered home servers on the EX495 and 3.5x faster video conversion on the EX490. a 115 min video can be converted in 70 mins, and 145 mins respectively according to HP. Storage is further boosted on the new models with the EX495 equipped with a 1 x 1.5Tb drive, and the EX490 packing a single 1Tb drive.
-HP's MediaSmart Server software updated to version 3.0 with a new, glossy user interface embedded into the Windows Home Server Console. A new web interface also allows you to easily control your home server when accessing remotely. The MediaSmart's Media Collector has also been upgraded to allow automatic music, video and photos to be collected from PCs and now Apple Macs as well. Amazon S3-powered Server Online Backup feature has been removed, and will be delivered through a new "Add Software" website linked from the MediaSmart Server's Console.
-HP have significantly ramped up the MediaSmart Server's support for Apple Macs running Leopard and Snow Leopard, including: Full OS Backup and Restore; Automatic media collection includes Mac iPhoto, iTunes, and iMovie libraries on the Mac; Windows Home Server Connector for the Mac


text: As a yoga teacher, we want to share the health and wellness benefits of the "ohms" and yoga poses to everyone. And cultural diversity shouldn't be a problem. With that, we give you tips on how to love and embrace different cultural background through yoga. Embarking on a wonderful journey …Read More »


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Unstrained Mercy Series
Contributed by Alison Bucklin on Jun 27, 2006 (message contributor)
Summary: Unstrained mercy needs to be constrained by the same constraints that God himself recognizes: by wisdom, by justice, by the long-term, eternal good of the person you are trying to help.
Every week it seems like there's another new disaster. Wasn't Hurricane Katrina enough, without adding Hurricane Rita to it? We were all so overwhelmed by the magnitude of those twin crises that many of us probably didn't even pay much attention to the fires in California. After all, they weren't really anything out of the ordinary, they happen practically on a yearly basis. We've pretty much all been collectively shaking ourselves off and getting down to the business of rebuilding, with the usual arguments of how much and who pays and whose fault was it all anyway. But almost before we'd started catching our breaths, there came the earthquake in Pakistan and Kashmir. The thousand dead and billions in damages in Louisiana and the rest of the Gulf Coast pale in comparison. The death toll is 40,000 and rising, thousands are still without even a tent over their heads, and it is beginning to snow. The floods in New Jersey and New York and New England are hardly worth mentioning. What's next? Plague? Pundits are telling us that Avian flu is on its way. No famine this year, I guess, at least no more than the usual malnutrition, and the wars are all pretty small. Even the one in Iraq.
Was there really a time when we all thought that a trouble-free life was a natural right? Was there really a time when we all thought that disaster was something that happened to other people? Was there really a time when we could comfortably coast from day to day and never face up to the fact that life is a precarious condition, one which we do not dare take for granted?
Back in the middle ages - and indeed, through many times in the history of Western civilization - people deliberately kept the reality of death and failure and loss squarely in front of them. They often did this with images like skeletons, or the grim reaper, or tombstones. They were called memento mori, or reminders of death. In ancient Rome, the phrase is said to have been used on the occasions when a Roman general was parading through the streets of Rome. Standing behind the victorious general was a servant, and he had the task of reminding the general that, though he was up on the peak today, tomorrow was another day. The servant did this by telling the general that he should remember that he was mortal, i.e. "Memento mori", or perhaps, "Respice post te! Hominem te esse memento!" (Look behind you! Remember that you are but a man!) But the primary classical response to the imminence of death was carpe diem: "seize the day," eat drink and be merry, for tomorrow you will die. Most memento mori works are products of Christian art The prospect of death served to emphasize of the emptiness and fleetingness of earthly pleasures, luxuries, and achievements, and invited people to focus their thoughts on the prospect of the afterlife instead. It wasn't considered morbid, or unhealthy, or defeatist.
Some people are sure that such disasters are God's judgment on sinners. I'm sure you remember some of the things that were said after 9/11, about God's judgment on America's sins. I think Jesus pretty much puts that interpretation to rest in the story Luke tells: "There were some present at that very time who told [Jesus] of the Galileans whose blood Pilate had mingled with their sacrifices. And he answered them, "Do you think that these Galileans were worse sinners than all the other Galileans, because they suffered thus? I tell you, No; but unless you repent you will all likewise perish. Or those eighteen upon whom the tower in Siloam fell and killed them, do you think that they were worse offenders than all the others who dwelt in Jerusalem? I tell you, No; but unless you repent you will all likewise perish." [Lk 13:1-5] So when people ask, at times like this, "How can a God of mercy allow this sort of disaster to happen?" one of the answers needs to be, "so that we will remember that we are not gods."
There are times when mercy - like forgiveness - is most loving when it is temporarily withheld. Like our comfortable lives in 20th century America, God's grace is something we may have come to take rather too much for granted.
There's a pretty strong correlation between forgiveness and mercy. Scripture talks about them in the same way: "Blessed are the merciful, for they will receive mercy," is phrased in exactly the same way as, "Do not judge, and you will not be judged; do not condemn, and you will not be condemned. Forgive, and you will be forgiven; give, and it will be given to you ... for the measure you give will be the measure you get back." [Luke 6:37-38] And it's commanded for exactly the same reason: we are to be merciful and not to judge, to give and to forgive - because God will treat us as we treat others.
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We understand that losing a loved one is a very difficult time and you may not know what to do. These first steps will help guide you. At M&F Funeral Services, you can call us anytime day or night and we'll help to guide you through.
When you need us, we'll be there.
It is both sensible and practical to plan ahead and an M&F Funeral Plan does more than just cover the cost of a funeral it provides an opportunity to arrange the funeral exactly as you want it. After all, every one of us has our own requirements and preferences.
When you need us, we'll be there.
We believe we provide the highest quality service at the best price with affordable, dignified and respectful funerals to suit all requirements and budgets.
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We believe we provide the highest quality service at the best price. Our pricing structure is here to help you make a more informed decision when it comes to selecting a funeral. With Funerals starting from £1350 (excluding third party costs).Download here
M&F Funeral Services believe we provide the highest quality service at the best price. Fill out our online quote form and we'll get back to you within 24 hours.Online quote
Thank you for all the help. We were delighted with the Orders of Service & the music you got for us. It made a sad day bearable for us.
From all the family of Isabel Rugg
We would like to say a huge thank you to all the staff at M&F who contributed to the care of the late John Anderson and his funeral arrangements, the advice and the assistance given made a difficult time easier. Many thanks.
Lorraine, on behalf of the Andersons
Thank you so much for the personal care and attention you gave to us when arranging my brothers funeral. Everything went off beautifully largely due to your friendliness and attention to detail. Thank you again.
Shirley & David Whaley
I just want to say thank you on behalf of me & my family for everything you did for our mum & us. A fantastic personal service that won't be forgotton, thank you from our hearts.
Liz, Hazel, Michael & Rob
Thanking you all for excellent service
Hazel Thornton and family
Just a little note to thank you for your help in putting my sister to rest. It was very much appreciated and I can't thank you enough
Marion and Matt Logan
From start to finish you dealt with our dear mum's funeral in a professional, caring and understanding way. You made the difficult process for a grieving family easier to bear. We are very grateful. With our thanks and very best wishes.
The family of Helen McRae


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Chaque lundi...
...Mélisse and I can be found at the same table in the Quincallerie on Rachel. It's time for our weekly language exchange; French one week and English the next. On Uli's recommendation, we started out in a certain St. Denis tea lounge, but let's just say that Mélisse and I prefer a more alcohol-oriented environment. It makes the conversation flow a little more easily when we've both had a long day. And this trendy place does nicely. The barmaid who works on Monday evenings even recognises us, and after just a couple of weeks knows what our drinks are without prompting (rousse for me, blonde for Mélisse).
We talk about our jobs, our travels, our futures (apparently I shouldn't go to Strasbourg, although Mélisse hasn't actually been herself) and the lives around us. We've both been here a few months now, and we've both adapted our Montréal dreams to cope with the Montréal reality. And we're happy. We've not been beaten. I'm speaking more French, and Mélisse is speaking more English. We have just enough to get by and to enjoy ourselves... things are good. I felt my spirits lift here this evening. Not every nagging question has an answer, but since I've got this far without too many problems, I reckon things will be ok.


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If you read my last post, and you're interested in Local Touring you may be wondering how to start. One word. Bags.
The handlebar bag is the gateway drug to bicycle utility. They give you the ability to carry some stuff without mounting a rack directly to your bicycle. A bar bag will keep things close at hand and easily accessible even while riding.
Here are 3 great options.
The waterproof bar bag from Banjo Brothers. The least expensive way to start adding bags to your bike. It has internal stiffeners to maintain the bags shape, a map pocket on top, mesh side pockets. It comes with a shoulder strap for off bike carrying, and bracket to attach the bag to your bar. Dimensions are 8″ H x 9″ L x 6″ W. The bag opens toward you. Imported
The Paloma from Swift Industries. Made in a small shop in Seattle the Paloma is a small bag made of the best water resistant fabrics. It's just the right size for a day on the bike. The bag opens away from you making it even easier to access your stuff. Dimensions are 10″w X 6″d X 6″h. Bar adapter bracket priced separately from bag. Made in the USA.
If you like the tradition of waxed canvas and leather the BarSack from Sackville is the bag for you. Sackville is the bag brand from Rivendell Bicycle Works. This bag features magnetic top flap closure, two side pockets and zip front pocket. Top flap opens the way it should-away from you. Attaches to your bar with the super swanky rack from Nitto (not included). Dimensions 9.5″ wide to side x 7″ front-to-back x 8″ tall. Expensive to buy, but cheap to own. This bag will serve you for a long time. Made in the USA.
Next time I'll tackle other options for carrying stuff on the front of your bike. Racks, and panniers and baskets-Oh my!


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This shimmering clutch by Amsterdam-based designer Hester van Eeghen has a stingray skin exterior and a calfskin interior and is designed to be worn on the hand like jewellery. Early civilisations associated stingrays with power and, based on this notion, van Eeghen's bag combines modern elegance with bold colours. Van Eeghen remains as involved in her work as she was 30 years ago when she left law studies to pursue her passion for accessory design. She continues to design each piece from her studio in Amsterdam, before travelling to Milan to oversee manufacture in carefully selected workshops.
Hester van Eeghen clutch bag, €550
Hester van Eeghen, Hartenstraat 37, 1016 CA Amsterdam, +31 (0)20 626 9212


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The Windup Girl – Review
An interesting read to start with, drops the reader straight into the near future world of a post oil civilisation, and the issues raised by this.
The main characters seem well constructed, and the plot moves at a nice pace. It is not quiet the action thriller page turner, but it is also not so slow that I want to put it down all the time. The chapters are a nice length, and allow for the reading of one or two before bed.
The characters while at times a feeling like they are simply filling a space, do have depth in parts. Some that comes out as the book goes on.
In general I'd say this is good read and worth looking up.


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Freeze Frame is an entertainment venue and digital imaging company. The company provides souvenir photos at zoos, amusement parks, and more.
Company (Acquired)
Phone: 407-648-2111
New York, United States
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|Nov 25, 2015
|Apr 17, 2018


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Resist, Persist, Vote
With continuous attacks on Medicaid and Title X funding coming from both the federal and state level, having a brick wall in the governor's seat to resist these attacks and block any cuts from the state legislature is essential. Without the Governor's veto, access to preventative, lifesaving health care for low-income Minnesotans would be on the chopping block.
Access to affordable health care at Planned Parenthood could hinge on the 2018 gubernatorial election.


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TORONTO � Mr. Hockey says people should cut Sid The Kid some slack.
Hockey legend Gordie Howe doesn�t believe Pittsburgh Penguins captain Sidney Crosby intentionally failed to shake hands with some Detroit players after Game 7 of the Stanley Cup final.
Howe said Crosby�s natural shyness combined with getting caught up in the emotion of winning an NHL championship resulted in Crosby getting in line to shake hands after some Red Wings had left the ice.
�He got caught up,� Howe said Thursday after serving as the Queen�s Plate honorary drawmaster at Woodbine Racetrack. �He will mature.
�He�s a good kid.�
During a chaotic post-game scene on the crowded Joe Louis Arena ice following Pittsburgh�s 2-1 victory, Crosby was ushered to several live television interviews, hugged some teammates and was presented the Stanley Cup by commissioner Gary Bettman.
Crosby was celebrating when Wings captain Nicklas Lidstrom, assistant Kris Draper and some other key Red Wings went to their dressing room. Crosby did get into line to shake hands with Detroit players, including head coach Mike Babcock and goalie Chris Osgood.
Draper later ripped Crosby, accusing him of snubbing Lidstrom during post-game handshakes.
But Howe, 81, defended Crosby, saying the Penguins superstar is really very shy. In fact, during a recent visit with Crosby, Howe added the Pittsburgh captain didn�t say a word.
�He�s too damn shy,� Howe said. �He never said a word, never blinked.
�During the five minutes I talked to him I basically said, `Don�t let anything bother you, just keep on the right road. You�re on the right road and you�re doing a hell of a lot of good jobs and good luck.� He just stared at me, turned around and walked away.�
And that brought a smile to Howe�s face.
�I just grinned and said, `That takes me back to the days where I used to hide,�� Howe said. �That�s because I was afraid I might say something wrong.
�I was the same way. I�d go into the washroom and take about a half-hour shower and they (reporters) would get sick of waiting and leave. I was afraid of saying something wrong and I think he�s in that same situation, he doesn�t know what to say, what is right and what is wrong?��
Howe � whose wife Colleen died in March at age 76 of Pick�s disease, a degenerative brain disorder � also remembers superstar Wayne Gretzky initially being very shy.
�The first time I met Wayne Gretzky � he never said anything back,� Howe said. �The second time, we couldn�t shut him up.
�It�s just kids. We all have to learn.�
As for Crosby�s ability as a hockey player, Howe said there�s plenty to be impressed with.
�I�m not going to say he knows everything, but he�s getting there fast,� Howe said. �A couple more years if he stays healthy, who knows?�
Howe said during his glory days with the Red Wings in the 1950s and �60s, the rivalries between teams were very intense, to the point where it was hard to shake hands after a series ended.
�When we had it you lined up at the blue-line and just banged hands,� he said. �You�re punching them in the nose and five minutes later you�re going to shake his hand?
�To hell with that. Maybe they shouldn�t even have the players out there.�
The Detroit-Pittsburgh final was an exciting one which saw the Penguins rally to capture the Stanley Cup by winning the final two games of the series. But Howe says he didn�t see it.
�Since I retired I�ve had to work,� he said with a chuckle.
2009 The Associated Press. All rights reserved.


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10g Upgrade issues
I had used the script bde_chk_cbo.sql from Metalink note: 174605.1 which builds a report consisting of the current, required and default values of your initialization parameters. The parameter in question was optimizer_secure_view_merging and according to the report it was undefined. Which means its using the default value of TRUE. According to Note 216205.1, Database Initialization Parameters for Oracle Applications 11i this parameter should be set to FALSE.
I checked my logs of the test upgrade and I did indeed set this parameter to FALSE. So I performed a search on metalink and found Note 404646.1, How To Set Parameter optimizer_secure_view_merging = FALSE Using Autoconfig. In summary, autoconfig isn't updating your pararameter file properly unless your on version 115.7 of the template file $ORACLE_HOME/appsutil/template/afinit_db102.ora. We have version 115.3 installed. This parameter is needed to avoid some performance issues with dictionary queries. If this applies to your environment, you should review the metalink note for the workaround.
Over the past month or so we have upgraded many environments to 10g, reverted some back to 9i, etc. It started to get confusing as to which environment was running 10g and which were still on 9i. (We have about 14 dev/test/project environments right now, with more planned.) One of my coworkers started up a 9i database with the 10g Oracle Home and we noticed something interesting:
ALERT: Compatibility of the database is changed from pre-10i to 10.2.0.0.0.
Increased the record size of controlfile section 2 to 256 bytes
The number of logical blocks in section 2 remains the same
Increased the record size of controlfile section 4 to 428 bytes
Control file expanded from 1614 blocks to 1644 blocks
Increased the record size of controlfile section 9 to 56 bytes
Control file expanded from 1644 blocks to 1672 blocks
Increased the record size of controlfile section 10 to 200 bytes
Control file expanded from 1672 blocks to 1694 blocks
kcv_lh_or_upgrade: 10.2 upgrading 1 incarnations
Control file expanded from 1694 to 1990 blocks for upgrade.
Setting recovery target incarnation to 1
Wed Jun 20 00:11:34 2007
Successful mount of redo thread 1, with mount id 764203184
Wed Jun 20 00:11:34 2007
Database mounted in Exclusive Mode
Completed: ALTER DATABASE MOUNT
Wed Jun 20 00:11:34 2007
As you can probably guess by the messages above, the control file was modified. When the database was shutdown and started with the 9i software the following happened:
ORA-00201: controlfile version 184.108.40.206.0 incompatible with ORACLE version
Yikes! On Monday I'm going to see if I can recreate the control files and startup the database but right now i'm off to upgrade our production EBS database to 10g.
5 comments:
- amar said...
This is Amar.
Can u please mail me the procedure for upgrading the 9i database of apps to 10g.
mail id- firstname.lastname@example.com
- Chris said...
Hello, If you could I would also like to see your procedure of updating your database as we are getting closer to upgrading.
Looks like your 10g database is trying to start with 9i pfile.
start the database with the good 10g pfile file, I also came accros this issue and resolved it with the above solution.
- Sridevi Koduru said...
- This comment has been removed by the author.
- Sridevi Koduru (Oracleappstechnical.com) said...
Sridevi Koduru (Senior Oracle Apps Trainer Oracleappstechnical.com)
LinkedIn profile - https://in.linkedin.com/in/sridevi-koduru-9b876a8b
Please Contact for One to One Online Training on Oracle Apps Technical, Financials, SCM, SQL, PL/SQL, D2K at firstname.lastname@example.com | +91 - 9581017828.


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From dating to premarital to marriage counseling, Trahan Counseling can help you in any stage of your relationship development. We use the latest research, technology and coaching to provide you with new strategies for how to have a fulfilling and satisfying intimate relationship.
"Get It Right: Private Premarital Counseling Program": 10 or 6 Sessions Same-Sex Format now available Christian option available Get $60 off of your marriage license! (Full 10-Session Program only.) We specialize in relationships.
I offer individual, marital and family counseling services utilizing both a biblical worldview and a professional training background. We create better relationships through healthier boundaries.
Feelings of worry, sadness, & excitement are common during life transitions including getting married. I offer brides &/or couples coping & communication strategies to help now & in the future.
The FOCCUS© Pre-Marriage Inventory is designed to help engaged couples appreciate their unique relationship, learn more about themselves, and discuss topics important to their lifelong marriage.
Family Therapy Clinic of LA offers outpatient mental health counseling and psychological testing for children, adolescents and adults. We offer individual, couple and family counseling.
Initially, we will evaluate, not only your understanding of your current situation, but also explore what change or outcome you desire.
Because "I do" means different things to different people...Come get over 80% off of your marriage license while gaining skills for relational competence. Prepare your marriage for success with professionals specifically trained in Marriage & Family Therapy.
My name is Betty Jo Brenemen and I am a therapist licensed by the State of Florida as a mental health counselor that have worked in that capacity with both adults and adolescents.
Our premarital counseling program does not involve testing, nor judgments. It consists of valuable information on keys to a successful relationship.
Prepare/Enrich is a proven tool, developed to stimulate open dialogue between you and your partner on a variety of topics related to your relationship. Create a deeper, healthier relationship by investing time now learning essential tools utilized in successful marriages.
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Counseling should be part of pre-wedding to-dos. We provide a fun experience including working through personality styles, communication styles, family issues and a Prepare and Enrich Assessment.
Don't just plan for your wedding, plan for your marriage! We are here to give you some simple directions so you can be prepared for marriage's little -- and big -- surprises!
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We offer pre-martial counseling.
Marriage counseling, marriage preparation, marriage retreats, workshops and seminars.
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Differences are unavoidable but DUMB FIGHTS are optional! We offer counseling, "Dumb Fight" classes, and we are certified PREPARE/ENRICH Couples' Inventory providers.
Dr. Rotunda treats a wide range of troubles and stresses and develops strategies for better communication and helps you get on your way for a happy and healthy future.
Relationship Counseling, Pre-marital Counseling, Bridal Counseling
My name is Frank Trupiano. I'm the director of LifeDimensions. I've been working in the field of behavioral psychology for over twenty years. We provide individual, marriage, and family counseling.
Individual, marriage, and family counseling is offered on a graduated fee scale, for adults and adolescents. Counseling is provided by professional counselor and marriage and family therapist.
Seminars on enhancing your marriage, powerful parenting, and strengthening families can be taken.


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Mergers and Acquisitions
Investors continue to have a interest in the outpatient physical therapy market. Despite the declining reimbursements from governmental and other payors the investment community is interested in outpatient therapy due to a conflux of other factors. The ageing of the baby boomers, increased access to therapy by the newly insured, and aggressive cost savings programs by CMS and other major insurance companies to reduce costly surgeries and hospitalizations in favor or more conservative treatments such as physical therapy show a bright opportunity for investment.
As therapy practices consider development plans as well as exit strategies the plan often focuses on revenue stream, as good financials, productive contracts, and consistent referral sources make a willing provider and attractive merger or acquisition target.
Risk and the Value of Compliance
The future value of a company is tied to a commitment to compliance. Providers operating in today's world of audits, investigations and prepayment reviews mitigate risks through an effective and working compliance program based upon a risk assessment and designed to detect, correct and prevent compliance issues. An effective compliance program is more that an auditing checklist to ensure that all chart elements of documentation are in place. Physical therapy "platforms" and therapy investors alike seek to ensure that a platform is build on a solid foundation and that De Novo clinics as well as acquisitions don't increase risk. An effective and fluid compliance program based upon the seven elements to mitigate risk.
Due Diligence Support
Nancy Beckley and Associates have been providing support in mergers and acquisitions space for nearly 10 years working with provider therapy platforms, equity firms, financial lenders, brokers and consultants to assist in the due diligence process. Contract Nancy Beckley: nancy [at] nancybeckley [dot] com or call 414-748-4376 to confidentially discuss your project.


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Up the road she flew and towards the art gallery. Marianne was sure she heard footsteps behind her and was sure Richard had followed her out of the coffee shop. She was right. Just at the door to the gallery he tapped her shoulder.
"Why the rush?" he asked her before she could push open the door.
"I had to get back to work." She held up the bag of pastries as proof.
"But you left your receipt." He held it out, she took it.
"Thanks. I should be getting back."
Just then, Penny popped outside and took hold of the bag of baked goods. "I'll take these and get the coffee on. You two just carry on." Penny backed into the gallery giving Marianne a look that said, 'You didn't tell me your boyfriend looked like George Clooney.'
"I don't want to get you into trouble," Richard said as he watched the gallery door close behind Penny and noticed Xander hovering close by. "It's just that …"
"That what?" Marianne said, also noticing Xander and wondering if he was cross. She couldn't tell through the glass.
"It's just that I do mind that you blew me off like that. I don't get it," Richard said. "I was looking forward to us going out for a meal this week."
Marianne crossed her arms. She'd had enough of people lying to her. "And is that because the younger woman is out of town?"
"What younger woman?"
"Long dark hair, slim, gorgeous."
Richard looked puzzled, or at least he was doing a good job of looking puzzled. Marianne continued.
"Are there that many you don't know which one I mean? I'm talking about the one you took out to dinner on Friday night. Notting Hill Gate? I saw you get into a taxi with her. You kissed her."
Richard's mouth dropped open. He was caught out.