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Expert Weighs in on Recent AML Advances
Angelica Welch
Thursday, Sep 28, 2017
Harry Erba, MD, PhD
Four major approvals this year have dramatically improved the treatment landscape for acute myeloid leukemia (AML).
In April, FDA approved midostaurin (Rydapt) for adult patients with newly-diagnosed FLT3-positive disease. With August came approvals for enasidenib (Idhifa) for patients with relapsed or refractory IDH-2 mutated AML and CPX-351 (Vyxeos) for newly-diagnosed adult patients with therapy related disease or myelodysplasia-related changes. Most recently, the FDA approved gemtuzumab ozogamizin (Mylotarg) in September for the treatment of patients with newly-diagnosed CD33-positive AML.
In an interview with OncLive during the 2017 SOHO Annual Meeting, Harry Erba, MD, PhD, professor of medicine, director, University of Alabama (UAB) Hematologic Malignancy Program, UAB School of Medicine, reflected on these approvals and their effect on the treatment of AML moving forward.
What have been the significant updates in AML over the past year?
For the clinician, the most important updates in AML are really the FDA approvals, because now we have to think about how we are going to incorporate these new drugs into our clinical practice. For decades, we have been using 3-and-7 daunorubicin-idarubicin with cytarabine as initial induction therapy for AML.
What is the impact of the gemtuzumab ozogamizin approval?
Following the initial approval of gemtuzumab in 2000 based on relapsed/refractory patients with AML, there were a number of studies looking at the combination of gemtuzumab with chemotherapy in previously-untreated patients. There was a meta-analysis that combined gemtuzumab in various doses with induction and consolidation chemotherapy. Robert Hills published results from that meta-analysis which showed that there was a benefit in terms of overall survival, and event-free survival for CD33-positive AML patients who receive gemtuzumab ozogamizin during induction consolidation.
In my opinion, the 2 studies that drove that meta-analysis and the positive outcome were the French ALFA-0701 study that used a fractionated dosing schedule of 3 mg/m2 on days 1, 4, and 7, with standard daunorubicin 60 mg/m2 for 2 days, and cytarabine in patients ages 50 to 70. In that study, there was no benefit in terms of complete response rate for the addition of gemtuzumab, there was more thrombocytopenia, and a few cases of veno-occlusive disease—but importantly, there was an improvement in event-free and overall survival in the publication.
Then there is the MRC United Kingdom data showing that there was benefit, especially in younger patients who had core-binding factor AML, to adding a single dose of gemtuzumab ozogamizin, again 3mg/m2, on day 1 of induction.
Have you seen progress with FLT3 inhibitors? Are any distinguishing themselves?
The first drug approved this summer for AML was midostaurin. Midostaurin has actually been around for a long time. It is a kinase inhibitor that is not very specific for FLT3 and actually inhibits a number of kinases, serine-threonine kinases, and tyrosine kinases, which have been implicated in AML. As you know, it was studied in FLT3 AML and when added to chemotherapy, showed an improvement in event-free survival and disease-free survival for younger patients.
However, there remains the question as to what is really the target for midostaurin in that population. Is it just FLT3 or could it be any of the other kinases that it inhibits? If you use a more specific FLT3 inhibitor, does it benefit patients with FLT3-mutated AML? We were hoping that we'd see marginal additional improvements on the outcomes that were seen with midostaurin by really targeting FLT3, but that is yet to be seen.
There are a number of drugs in development that are not yet approved for FLT3-mutated AML. The ones that are the furthest along would be gilteritinib (ASP2215), an inhibitor of both the FLT3 ITD and tyrosine kinase domain mutation; quizartinib (AC220), an inhibitor of the ITD; and crenolanib, a dual inhibitor of both ITD and TKD mutations. And there are others. As single agents, all of those drugs have shown biologic activity. Blast counts go down and you see differentiation of blasts. However, very few patients achieve complete remissions with restoration of blood counts. I think the future is going to be looking at the addition of those novel FLT3 inhibitors to induction and consolidation treatment.
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After practicing law for more than 25 years we have the experience to help you with your legal needs. We are a small law firm and focus on bringing you the personal service that you deserve. Our fees are significantly lower than others because our overhead is low.
We offer free consultations. At the end of your consultation, we will form a plan, and tell you the cost of our services, and you will be able to decide if we are the right firm for you.

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Arizona Governor Signs Anti-Background Check Bill into Law
Here's a story that surprised us: Arizona has passed a bill that might outlaw future background check mandates regarding the transfer of private property. While this action isn't directly related to hiring, it doesn't take much imagination to see how it might eventually be relevant. Might a state legislature, at some point, outlaw background checks…Details


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A Forest on California's Central Coast Is in Danger. So Are the Butterflies That Live There.
Southern California's Ellwood Mesa, with nearly 80 acres of protected eucalyptus forest, is a refuge for the vanishing western monarch butterflies during the winter months. But the state's most recent drought has left the future of the forest in jeopardy.


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Av Francisco Bilbao 1439View on map
Phone: +56 (2) 25983300
Mon 08:00-20:00
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Navigating a whole new area on your own schedule was never easier than with a cheap car rental from Santiago Downtown Office. As soon as you arrive at Santiago Downtown Office, Chile, you can look forward to exploring straight away. As well as having the freedom to drive to exciting new locations on a whim, you can plan day trips and excursions to nearby attractions that capture your interest.
With a simple booking system and a great selection of vehicles, Europcar is the perfect choice for your Santiago Downtown Office car rental. Book online before you go and discover a range of options; we have hourly, daily, short term, weekly, monthly and long term deals available in this location, and you can talk to us to find out which one will be best suited to your trip.
Rent a car in Santiago Downtown Office and prepare to hit the road for a whole new heap of memories
Remember to always bring your driver's license, valid credit card and additional proof of identity (such as a passport if you are renting abroad).


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Modern days
Today everything is different and also for brides, today besides 'something blue and something borrowed' brides need to think about how not to make mistakes in our modern world, so right now we will mention just five of them which you should avoid or even better, take them as your new commandments
1.I Will Not Leave A Photo Of My Dress On My Phone
For something exceptional like a wedding dress, image posting on social media is out of the question. To ensure your fiancé doesn't discover a shot of you in the dress of your dreams, take those photos off your phone and save them elsewhere. Better yet, ask your Chief Bridesmaid to take them on her phone.
2. I Will Not Assume My Friend's iPhone Counts As the Photographer
With all the websites and apps out there, everyone seems to believe they can stand in as photographers, DJs or wedding planners. But while some things can be done well by amateurs, certain things do require professionals. And we don't want you to end up with fuzzy photos before you comprehend your miscalculation. Be honest with yourself and figure out your budget and priorities. This is one of the most important days of your life. Can you live with overexposed photos that the whole world can see? Things like collecting supposedly high-quality music as well as last-minute wedding-day troubleshooting are skill sets that most non pros simply don't have. So know what you can handle and what you cannot, and hire a professional whenever possible to save yourself from tears later.
3. I Will Not Buy My Dress on A Shady Website
We all know how expensive planning a wedding can be, which makes the so-called discount websites very appealing. If a ₤5,000 dress is selling for ₤50 and sounds too good to be true, it probably is — even if you see a great looking photo of it on the website. It's best to go to actual brick-and-mortar stores for something like your wedding dress. That way you can see what it looks like on. If ordering online is just a lot more convenient, make sure the site you're buying from is approved by a designer. One big hint that it's probably not, is if the site also sells random items like batteries. (Seriously)
4. I Will Not Forgo Paper Wedding Invitations for .jpg Files
With so many technological advances, there may be more people who are okay with emailing their wedding invitations these days. But is it really a good idea to totally let go of old, time-tested traditions? – Especially if Great Grandma doesn't even have a computer? Besides, it's so much more romantic writing out a pretty invitation and posting them out to family and friends.
5. I Will Not Turn My Face book Feed In to a Wedding Vent
Yes, we know there's a lot of stress in planning a wedding. Whether its struggles with in-laws or guests not being the most generous with their gifts, you just want to blow off some steam. Along comes Face book, Twitter, group emails and What's App. So what's a quicker and better way to share your concerns with anyone who will listen, right? Consider this: We've seen complaints by brides go viral, leading them to infamy and (sometimes) prolonged, public humiliation. So before you pour your heart out, check the privacy settings on all your social-media accounts and make sure none of your complaints can be seen by the public. Ensure that the names of the groups you're in contact with through both What's App and email are very clear, so you won't end up talking about your in-laws to your in-laws. That definitely wouldn't be good.


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For Immediate Release
June 29, 2008
Celebrating Hopes, Dreams and Achievements at the Timms Centre for the Arts
Friday July 4th, 2008, 7:00 pm
Tickets are available for $5.00 from Tix on the Square http://www.tixonthesquare.ca, by calling 780-420-1757, or at the door.
Presented by the Canadian Authors Association-Alberta Branch in conjunction with CanWrite! 2008 www.canauthorsalberta.ca/Canwrite.
Sponsored by the Canadian Literature Centre.
For more information or to book an interview, please contact:
Suzanne Harris, Event Coordinator at 780-975-9259 or
Anthony Dalton, Awards Chair at 604-219-0642


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The INTACT project aims to draw together knowledge from stakeholders and experts, analyses and assessments, to help and make critical infrastructure more resilient to extreme weather. As such the potential benefits of the project for European infrastructure is self-evident. In order to make the results of this complicated undertaking usable and accessible, the findings will be brought together in the INTACT Wiki.
This wiki provides a platform for users to search for expertise, research, results and outcomes across the range of subject areas examined for this project. This includes different geographical areas, climate conditions, particular forms of extreme weather events, or the merits of different strategies and approaches compared to others. The INTACT Wiki will be designed to be an easy to use tool for decision makers, stakeholders involved in the development process of critical infrastructure, or those involved in operational management of infrastructure or crisis response. It will feature a number of convenient entrance points, catering to specific informational needs, amongst which you will find information for specific geographical areas, governmental bodies, CI operators, specific CI sectors, best practices and experiences, and a quick and convenient reference guide summarizing the main topics in the wiki.
In short, the results and outcomes of the INTACT project will be available to anyone who wishes via the INTACT Wiki.


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Minilands popular Activity Mecaniko with new elements and new design. Every young engineer can build objects from the real world. The set is made of durable plastic and includes a spanner, screws, pulleys, nuts, etc. To encourage children´s abilities, 6 large sheets detailing the construction of various designs are included.
Age Guide: 4+
81 Pieces and 6 activity cards
FREE Australia wide delivery applies to all orders with a goods value of $100 or more. (Includes signature delivery and a traceable consignment number).
A flat $8.95 delivery charge applies to all Australian orders under $100. (This charge includes signature delivery and a traceable consignment number).
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- Home »
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For HTC Desire 728 Front Housing Replacement - White - Grade S+
This item includes the following parts:
1. Front Housing;
2.Ear Speaker Mesh Cover.
Color: White
Compatibility: HTC Desire 728
● This front cover contains: Ear Speaker Mesh Cover.
● The replacement is used for damaged or broken front housing.
● This front housing is applied for HTC Desire 728 only.
● Original and brand new front bezel replacement for Desire 728.
● This item is White, please note and choose the right color before placing the order.
How to Install / Tips:
● Please try to handle the repair or replacement work in a dry and dust free environment without direct sunlight.
● Please put the screws in a safe place when you disassemble the broken HTC Desire 728 front housing part. This new front cover provided by ETS does not include the screws.
● The installation of the HTC Desire 728 front housing replacement should be done by a qualified person. ETS is not responsible for any damage caused during installation.
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Are you curious to learn, how airplanes fly? In this mission, you will learn about the four forces that work together to make flying an airplane possible. Click on the "ENROLL" tab to the right to accept your mission to learn what makes airplanes fly!!!
The following certificates are awarded when the class is completed:
|Junior Test Pilot


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The Story of the World's Greatest Paintings
The Story of the World's Greatest Paintings
Thames & Hudson / 2010 / Hardcover
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This brilliantly produced art book will capture the imaginations and senses of your young students, giving them inspiration for plenty of art studies in the future! Twenty masterpieces are featured, and the accompanying notes look at how each was created, who it was made for, and what people have thought of it over the years.
Chronologically ordered, children will learn the lessons and stories behind the paintings; "Look at this" sections highlight specific details in the painting, "Why don't you" sideboxes provide ideas for activities, while "Did you know?" questions point out interesting facts about the artist, time, or paintings.
Multiple paintings are shown, helping children to see how the artist used similar techniques or painted similar subjects. A chronology of the artists is provided in the back of the book. 96 pages, hardcover. Please note that some of the great, classic artwork featured depicts nudity. 11.75" x 10".
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The first downloadable content pack for Rocket League, entitled Supersonic Fury, is coming in early August.
Supersonic Fury includes two new Battle-Cars: The Dominus is an over-the-top American muscle car, and the Takumi is a Japanese street racer.
The DLC also includes two new rocket boosts called Nitrous and Burnout, two new wheel sets called Cristiano and Spinner, and five new paint types.
As well as Supersonic Fury, which costs $4 / €4, Psyonix is also releasing a free game update. This update adds the new map Utopia Coliseum, and more than 70 new country flags. Spectator mode is also being added, allowing you to watch games in real time from any camera angle.
Updated goal explosions and demolitions are also planned for the free update, as well as a new song called Firework from Hollywood Principle.
According to the post on the PS Blog, this is "just the beginning of what is plenty more to come."
Rocket League has now been downloaded over 5 million times since its release. Check out IGN's review of the "great" and "goofy" Rocket League right here.
Matt Porter is a freelance writer based in London. Make sure to visit what he thinks is the best website in the world, but is actually just his Twitter page.


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Oops. . .
"I don't think anybody anticipated the breach of the levees"
Festus said that today. It has a familiar ring to it because Condi Rice said something similar about planes hitting buildings during her confirmation hearings. ("I don't think anyone could have predicted that these people would take an airplane and slam it into the World Trade Center." - May 17, 2002) She was incorrect then, because Clinton's transition team warned Bush of exactly that possibility, yet Bush decided he didn't want to "swat at flies" and directed a shift of focus on "Axis of Evil" nations instead of flies like Osama bin Laden.
Similarly I read that, the Festus administration made conscious decisions to downgrade the Federal Emergency Management Administration as well as cut funding that would have strengthened the levies in New Orleans. So to save a few million here and there and send the message to the states that the Federal government wasn't the answer to all their funding needs, thousands die unneccessiarly and billions in property damage are sustained because Festus didn't think it was worth the money.
New Orleans had long known it was highly vulnerable to flooding and a direct hit from a hurricane. In fact, the federal government has been working with state and local officials in the region since the late 1960s on major hurricane and flood relief efforts. When flooding from a massive rainstorm in May 1995 killed six people, Congress authorized the Southeast Louisiana Urban Flood Control Project, or SELA.
Over the next 10 years, the Army Corps of Engineers, tasked with carrying out SELA, spent $430 million on shoring up levees and building pumping stations, with $50 million in local aid. But at least $250 million in crucial projects remained, even as hurricane activity in the Atlantic Basin increased dramatically and the levees surrounding New Orleans continued to subside.
Yet after 2003, the flow of federal dollars toward SELA dropped to a trickle. The Corps never tried to hide the fact that the spending pressures of the war in Iraq, as well as homeland security -- coming at the same time as federal tax cuts -- was the reason for the strain. At least nine articles in the Times-Picayune from 2004 and 2005 specifically cite the cost of Iraq as a reason for the lack of hurricane- and flood-control dollars.
Newhouse News Service, in an article posted late Tuesday night at The Times-Picayune Web site, reported: "No one can say they didn't see it coming. ... Now in the wake of one of the worst storms ever, serious questions are being asked about the lack of preparation."
In early 2004, as the cost of the conflict in Iraq soared, President Bush proposed spending less than 20 percent of what the Corps said was needed for Lake Pontchartrain
We at Heavy Sigh like to be fair and balanced, so here's Festus's elaboration on how he managed to say something so amazingly stupid.
No, what I was referring to is this. When that storm came by, a lot of people said we dodged a bullet. When that storm came through at first, people said, whew. There was a sense of relaxation, and that's what I was referring to. And I, myself, thought we had dodged a bullet. You know why? Because I was listening to people, probably over the airways, say, the bullet has been dodged. And that was what I was referring to.
Of course, there were plans in case the levee had been breached. There was a sense of relaxation in the moment, a critical moment. And thank you for giving me a chance to clarify that.
"Relaxation", "the bullet has been dodged", I'm surprised he left out "What's the difference?"


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Bucs contemplating foreign spot
Posted: 22 August 2018 Time: 15:34
Orlando Pirates are currently considering their options before filling their final foreign spot for the first half of the 2018/19 season, as a Brazilian duo lie in wait.
Pirates have been assessing Brazilian defender Caio Marcelo as well as a goalkeeper during the recent pre-season, with head coach Milutin Sredojevic having refused to make pronouncements on the outcome thereof in recent weeks.
READ: Pirates ship out striker to Cosmos
Marcelo, 19, featured and apparently impressed in all the Buccaneers' friendlies in Zambia, including against Congolese giants TP Mazembe.
However, 'Micho' has remained mum on whether the club could sign the left-footed centre-back or the shot-stopper, referring any confirmation to their 'official channels'.
According to Pirates administrative officer Floyd Mbele, a final decision is yet to be made by the club as they only have one remaining spot within their quota for foreign registrations.
"I think there are a number of permutations that we are looking at, and that's facilitated by the fact that there's just one foreign space that's left," Mbele tells KickOff.com.
"So we need to be absolutely sure what we're going to do with that foreign space. There are a number of considerations we have to make, not just about them [Brazilian duo] but about the last foreign slot.
"The next couple of days [before the transfer window closes] will be crucial for us to zero in on what we'll be doing with that one space."
Pirates currently have Zimbabwean pair Marshall Munetsi and Kudakwashe Mahachi, as well as Zambians Justin Shonga and Augustine Mulenga occupying their five foreign spots.
READ: Pirates rotation proving costly?
At this stage, it would seem unlikely that the Brazilian goalkeeper could make the cut, given the foreign limitations and the presence of four top keepers already on the club's books.
However, Marcelo could well make the cut as Sredojevic looks to finalise his squad before the transfer window closes on August 31.
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I do not have exact figures, but have been told that the number of absentee ballots received in Northampton and Lehigh County for today's election is unusually low. In Lehigh County, it might be the lowest level in 20 years.
The number of absentee ballots received in a primary election is usually lower than the general. But given the number of candidates seeking a seat in Congress (six Democrats, two Republicans), I thought there would be more.
Does a drop in absentee ballots indicate turnout will below? It may mean nothing at all. It may mean people are disgusted by government and have tuned out. It may mean they are just disgusted with LV candidates.


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Amish Cabinets Of Texas
Monday, October 2nd, 2017
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As adverb
in what way or manner; by what means?:How did the accident happen?
to what extent, degree, etc
?:How damaged is the car?
in what state or condition?:How are you?
for what reason; why?:How can you talk such nonsense?
to what effect; with what meaning?:How is one to interpret his action?
what?:How do you mean? If they don't have vanilla, how about chocolate?
(used as an intensifier):How seldom I go there!
by what title or name?:How does one address the president?
at what price:How are the new cars going, cheaper than last year's models?
by what amount or in what measure or quantity?:How do you sell these tomatoes?
in what form or shape?:How does the demon appear in the first act of the opera? How does the medication come?
As conjunction
the manner or way in which:He couldn't figure out how to solve the problem
about the manner, condition, or way in which:I don't care how you leave your desk when you go
Be careful how you act
in whatever manner or way; however:You can travel how you please
that:He told us how he was honest and could be trusted
As noun
a question concerning the way or manner in which something is done, achieved, etc
:a child's unending whys and hows
a way or manner of doing something:to consider all the hows and wherefores
a word formerly used in communications to represent the letter H
As Idioms
and how!, Informal
certainly! you bet!:Am I happy? And how!
Here's how, Informal
(used as a toast)
how come?, Informal
how is it that? why?:How come you never visit us anymore?
how so?, how does it happen to be so? why?:You haven't any desire to go? How so?
As preposition
(used for expressing motion or direction toward a point, person, place, or thing approached and reached, as opposed to from):They came to the house
(used for expressing direction or motion or direction toward something) in the direction of; toward:from north to south
(used for expressing limit of movement or extension):He grew to six feet
(used for expressing contact or contiguity) on; against; beside; upon:a right uppercut to the jaw; Apply varnish to the surface
(used for expressing a point of limit in time) before; until:to this day; It is ten minutes to six
We work from nine to five
(used for expressing aim, purpose, or intention):going to the rescue
(used for expressing destination or appointed end):sentenced to jail
(used for expressing agency, result, or consequence):to my dismay; The flowers opened to the sun
(used for expressing a resulting state or condition):He tore it to pieces
(used for expressing the object of inclination or desire):They drank to her health
(used for expressing the object of a right or claim):claimants to an estate
(used for expressing limit in degree, condition, or amount):wet to the skin; goods amounting to $; Tomorrow's high will be to °
(used for expressing addition or accompaniment) with:He added insult to injury
They danced to the music
Where is the top to this box?
(used for expressing attachment or adherence):She held to her opinion
(used for expressing comparison or opposition):inferior to last year's crop; The score is eight to seven
(used for expressing agreement or accordance) according to; by:a position to one's liking; to the best of my knowledge
(used for expressing reference, reaction, or relation):What will he say to this?
(used for expressing a relative position):parallel to the roof
(used for expressing a proportion of number or quantity) in; making up: to the dozen; miles to the gallon
(used for indicating the indirect object of a verb, for connecting a verb with its complement, or for indicating or limiting the application of an adjective, noun, or pronoun):Give it to me
I refer to your work
(used as the ordinary sign or accompaniment of the infinitive, as in expressing motion, direction, or purpose, in ordinary uses with a substantive object
raised to the power indicated:Three to the fourth is ( = )
As adverb
toward a point, person, place, or thing, implied or understood
toward a contact point or closed position:Pull the door to
toward a matter, action, or work:We turned to with a will
into a state of consciousness; out of unconsciousness:after he came to
As Idioms
to and fro
fro (def )
As noun
a substance composed of solid coloring matter suspended in a liquid medium and applied as a protective or decorative coating to various surfaces, or to canvas or other materials in producing a work of art
an application of this
the dried surface pigment:Don't scuff the paint
the solid coloring matter alone; pigment
facial cosmetics, especially lipstick, rouge, etc
, designed to heighten natural color
Chiefly Western U
a pied, calico, or spotted horse or pony; pinto
As verb (used with object)
to coat, cover, or decorate (something) with paint:to paint a fence
to produce (a picture, design, etc
) in paint:to paint a portrait
to represent in paint, as in oils, tempera, or watercolor:to paint an actress as the Muse of tragedy
to depict as if by painting; describe vividly in words:The ads painted the resort as a winter wonderland
to color by or as if by painting:Sunset painted the clouds pink
to apply a substance to, as a liquid medicine or a cosmetic:to paint a cut with iodine
As verb (used without object)
to coat or cover anything with paint
to engage in painting as an art:She has begun to paint in her spare time
to put on or use facial cosmetics
As Idioms
paint the town red, Informal
to celebrate boisterously, especially by making a round of stops at bars and nightclubs
Also, paint the town
As noun
any of a class of elementary substances, as gold, silver, or copper, all of which are crystalline when solid and many of which are characterized by opacity, ductility, conductivity, and a unique luster when freshly fractured
such a substance in its pure state, as distinguished from alloys
an element yielding positively charged ions in aqueous solutions of its salts
an alloy or mixture composed wholly or partly of such substances, as brass
an object made of metal
formative material; stuff
type metal
the state of being set in type
molten glass in the pot or melting tank
road metal
As verb (used with object), metaled, metaling or (especially British) metalled, metalling
to furnish or cover with metal
to pave or surface (a road) with broken stone
As noun
a folder, cabinet, or other container in which papers, letters, etc
, are arranged in convenient order for storage or reference
a collection of papers, records, etc
, arranged in convenient order:to make a file for a new account
a collection of related data or program records stored on some input/output or auxiliary storage medium:This program's main purpose is to update the customer master file
a line of persons or things arranged one behind another (distinguished from rank (def
a person in front of or behind another in a military formation
one step on a promotion list
one of the vertical lines of squares on a chessboard
a list or roll
a string or wire on which papers are strung for preservation and reference
As verb (used with object), filed, filing
to place in a file
to arrange (papers, records, etc
) in convenient order for storage or reference
to arrange (copy) in the proper order for transmittal by wire
to transmit (copy), as by wire or telephone: He filed copy from Madrid all through the war
As verb (used without object), filed, filing
to march in a file or line, one after another, as soldiers:The parade filed past endlessly
to make application:to file for a civil-service job
As Idioms
on file, arranged in order for convenient reference; in a file:The names are on file in the office
As noun
a piece of furniture with shelves, drawers, etc
, for holding or displaying items:a curio cabinet; a file cabinet
a wall cupboard used for storage, as of kitchen utensils or toilet articles:a kitchen cabinet; a medicine cabinet
a piece of furniture containing a radio or television set, usually standing on the floor and often having a record player or a place for phonograph records
(often initial capital letter) a council advising a president, sovereign, etc
, especially the group of ministers or executives responsible for the government of a nation
(often initial capital letter) (in the U
) an advisory body to the president, consisting of the heads of the executive departments of the federal government
a small case with compartments for valuables or other small objects
a small chamber or booth for special use, especially a shower stall
a private room
a room set aside for the exhibition of small works of art or objets d'art
Also called cabinet wine
a dry white wine produced in Germany from fully matured grapes without the addition of extra sugar
New England (chiefly Rhode Island and Southern Massachusetts)
a milk shake made with ice cream
a small room
a small cabin
As adjective
pertaining to a political cabinet:a cabinet meeting
private; confidential; secret
pertaining to a private room
of suitable value, beauty, or size for a private room, small display case, etc
:a cabinet edition of Milton
of, relating to, or used by a cabinetmaker or in cabinetmaking
designating a method of projection (cabinet projection) in which a three-dimensional object is represented by a drawing (cabinet drawing) having all vertical and horizontal lines drawn to exact scale, with oblique lines reduced to about half scale so as to offset the appearance of distortion
Compare axonometric, isometric (def ), oblique (def )
You have to have got exciting creative ideas just like How To Paint Metal File Cabinet graphic stock if you would like employ a dwelling using a specific glimpse. In addition to majority, superb property style and design like around How To Paint Metal File Cabinet pic gallery is a really spot for a get back your mood. What you should do is actually gain knowledge of How To Paint Metal File Cabinet photo gallery and additionally embrace the elements that correspond to your own persona. Moreover, you may will use this How To Paint Metal File Cabinet pic gallery to be a way to obtain guidelines to finished your ideas for you to have already got before accentuate your personal property. If you want a completely unique glimpse, you can unite several methods of How To Paint Metal File Cabinet picture stock. Considering How To Paint Metal File Cabinet graphic stock sole can provide HIGH-DEFINITION photos, so it s possible to pull together it not having stressing about the level of quality. Viewing such particulars, How To Paint Metal File Cabinet image stock would have been a excellent supply of determination in your case. Take pleasure in your private query in this web site along with How To Paint Metal File Cabinet photo collection.
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trying to be an iphone!! but never it gets that way by not giving exp memory option!!!
liked it very much pretty good hardware.anyone sensed about the design? it's a direct copy of iPhone!!! lol......
micromaxx turbo is superb it have all the futures you were searching for get it now..........
Sudipto, 31 Oct 2013At least you should increase the storage capacity. Turbo may be a great phone but the storage ... moreI am also hunting for a best hardware on the phone, no doubt the specs are good on this phone 16gb memory is small and operating system hangs some times if you play a big graphics game on cheaper model, hope this phone should acomendate the bigger graphics without any issues check out gionee elife e6 phone with same specs with 32gb storage and has iphone5 looks
At least you should increase the storage capacity. Turbo may be a great phone but the storage capacity is too short.
Abhi, 29 Oct 2013Battery is 2000mah, not at all good. No external Memory, atleast it should have inbuild 32gb.... moreYou are right
first please improve your service, all these endorsements and high features phones are of no use. With this kind of poorest service you will never capture the market.
No Memory Expnd .It should hv space SD Card slot otherwise Micromax turbo is owsme Phone .
all is gud about micromax canvas turbo..but no micro sd card slot that disappoint...
Battery is 2000mah, not at all good.
No external Memory, atleast it should have inbuild 32gb.
Overall lag of battery and memory.
Not a good phone as per current mobile war.
Shakti Verma, 29 Oct 2013 Turbo is OTG Supported or not ? its also supported Pan Drive ?I just connected a 8gb pendrive via OTG and it worked perfectly fine.
I was planning to buy this mobile but due to limited storage place i am dropping the plan to buy this mobile, bcoz i like to store lot of video's , pic , movies which i cant do in this phone
very disappoint for external memory.
Then what the use of 2gb ram, if we canot download bigger size files.
the features are really good but the lack of external memorycard slot is dissapointing


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PPAR Research
Volume 2008, Article ID 723243, 8 pages
PPARs and Female Reproduction: Evidence from Genetically Manipulated Mice
Department of Physiology and Pathophysiology, Peking (Beijing) University Diabetes Center, Peking (Beijing) University Health Science Center, Beijing 100083, China
Received 1 July 2007; Accepted 6 December 2007
Academic Editor: Pascal Froment
Copyright © 2008 Jichun Yang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated nuclear receptors controlling many important physiological processes, including lipid and glucose metabolism, energy homeostasis, inflammation, as well as cell proliferation and differentiation. In the past decade, intensive study of PPARs has shed novel insight into prevention and treatment of dyslipidemia, insulin resistance, and type 2 diabetes. Recently, a large body of research revealed that PPARs are also functionally expressed in reproductive organs and various parts of placenta during pregnancy, which strongly suggests that PPARs might play a critical role in reproduction and development, in addition to their central actions in energy homeostasis. In this review, we summarize recent findings elucidating the role of PPARs in female reproduction, with particular focus on evidence from gene knockout and transgenic animal model study.


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geny opakující se
A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)
geny rev
DNA sequences that form the coding region for a protein that regulates the expression of the viral structural and regulatory proteins in human immunodeficiency virus (HIV). rev is short for regulator of virion.
Structural gene
genes which code for protein products; compare with GENETIC REGULATORY ELEMENT and REGULATORY GENE.
Biological macromolecule which is a segment of a DNA molecule and which consists of sets of nucleotide pairs organized into regions of coding, noncoding and regulatory sequences.
A gene that encodes a protein with a chief function as part of a physical structure within a cell. This is in contrast to genes that encode proteins with a function that is enzymatic or regulatory.
geny supresorové
Genes that have a suppressor allele or suppressor mutation (SUPPRESSION, GENETIC) which cancels the effect of a previous mutation, enabling the wild-type phenotype to be maintained or partially restored. For example, amber suppressors cancel the effect of an AMBER NONSENSE MUTATION.
geny spouštěcí
Genes that cause the epigenotype (i.e., the interrelated developmental pathways through which the adult organism is realized) to switch to an alternate cell lineage-related pathway. Switch complexes control the expression of normal functional development as well as oncogenic transformation.
geny syntetické
Biologically functional sequences of DNA chemically synthesized in vitro.
geny tat
DNA sequences that form the coding region for the protein responsible for trans-activation of transcription (tat) in human immunodeficiency virus (HIV).
geny virové
The functional hereditary units of VIRUSES.
Genes of viral origin.
genetický kód
The meaning ascribed to the BASE SEQUENCE with respect to how it is translated into AMINO ACID SEQUENCE. The start, stop, and order of amino acids of a protein is specified by consecutive triplets of nucleotides called codons (CODON).
genetická komplementace – testy
A test used to determine whether or not complementation (compensation in the form of dominance) will occur in a cell with a given mutant phenotype when another mutant genome, encoding the same mutant phenotype, is introduced into that cell.
genetické poradenství
An educational process that provides information and advice to individuals or families about a genetic condition that may affect them. The purpose is to help individuals make informed decisions about marriage, reproduction, and other health management issues based on information about the genetic disease, the available diagnostic tests, and management programs. Psychosocial support is usually offered.
educational process that provides information and advice to individuals or families about a genetic condition that may affect them; the purpose is to help individuals make informed decisions about marriage, reproduction, and other health management issues based on information about the genetic disease, the available diagnostic tests, and management programs; psychosocial support is usually offered.
A communication process between a specially trained health professional and a person concerned about the genetic risk of disease. The person`s family and personal medical history may be discussed, and counseling may lead to genetic testing.
If you are expecting a baby or planning to have a baby, your doctor can run many tests to help assess the health of both you and your baby. Your doctor may also refer you for genetic counseling. Genetic counseling provides information and support to people who have, or may be at risk for, genetic disorders. A genetics professional meets with you to discuss genetic risks. You may follow up with genetic testing.
There are many reasons to seek genetic counseling. You may consider it if you
- Have or are concerned you have an inherited disorder
- Are pregnant or planning to be pregnant after age 35
- Already have a child with a genetic disorder or birth defect
- Have had two or more pregnancy losses or a baby who died
- Have had ultrasound or screening tests that suggest a possible problem
The process whereby an expert in hereditary disorders provides information about risk and clinical burden of a disorder or disorders to patients or relatives in families with genetic disorders as an aid to making informed and responsible decisions about marriage, children, early diagnosis, and handling disability.
genetické inženýrství
Directed modification of the gene complement of a living organism by such techniques as altering the DNA, substituting genetic material by means of a virus, transplanting whole nuclei, transplanting cell hybrids, etc.
The technology of preparing recombinant DNA in vitro by cutting up DNA molecules and splicing together fragments from more than one organism.
indukce genetická
An increase in the GENETIC TRANSCRIPTION of a gene by the supply of an activator or removal of a repressor.
genetické markery
A phenotypically recognizable genetic trait which can be used to identify a genetic locus, a linkage group, or a recombination event.
Alteration in DNA that may indicate an increased risk of developing a specific disease or disorder.
A segment of DNA with an identifiable physical location on a chromosome and whose inheritance can be followed.
genetické techniky
Chromosomal, biochemical, intracellular, and other methods used in the study of genetics.
general heading term for methods, procedures, and processes for the study of genetics, including RNA and DNA chemistry.
Chromosomal, biochemical, intracellular, and other methods used in the study of genetics, including RNA and DNA chemistry.
genetické vektory
DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.
The branch of science concerned with the means and consequences of transmission and generation of the components of biological inheritance. (Stedman, 26th ed)
branch of science concerned with the means and consequences of transmission and generation of the components of biological inheritance; the study of genes and their heredity.
The study of genes and heredity. Heredity is the passing of genetic information and traits (such as eye color and an increased chance of getting a certain disease) from parents to offspring.
The branch of biology that deals with heredity, especially the mechanisms of hereditary transmission and the variation of inherited characteristics among similar or related organisms
genetic aspects
Used for mechanisms of heredity and the genetics of organisms, for the genetic basis of normal and pathologic states, and for the genetic aspects of endogenous chemicals. It includes biochemical and molecular influence on genetic material.
behaviorální genetika
The experimental study of the relationship between the genotype of an organism and its behavior. The scope includes the effects of genes on simple sensory processes to complex organization of the nervous system.
study of the relationship between the genotype of an organism and its behavior; includes the effects of genes on simple sensory processes to complex organization of the nervous system.
The study of the genetic factors of behavioral phenotypes such as eating or mating activity, substance abuse, social attitudes, violence, and mental abilities. (from online American Heritage Dictionary of the English Language)
Genetics, Biochemical
The science concerned with the chemical and physical nature of genes and the genome.
A branch of genetics which deals with the chemical structure of the genes and with the mechanisms by which the genes control and regulate the structure and synthesis of proteins.
genetika lékařská
A subdiscipline of human genetics which entails the reliable prediction of certain human disorders as a function of the lineage and/or genetic makeup of an individual or of any two parents or potential parents.
A medical specialty concerned with the diagnosis and management of hereditary disorders.
genetika mikrobiální
A subdiscipline of genetics which deals with the genetic mechanisms and processes of microorganisms.
heredity, especially the mechanisms of hereditary transmission and the variation of inherited characteristics among a microorganism or microorganisms; the genetic constitution of microorganisms.
A branch of genetics concerned with the mechanisms and processes of heredity in microorganisms.
genetika populací
The discipline studying genetic composition of populations and effects of factors such as GENETIC SELECTION, population size, MUTATION, migration, and GENETIC DRIFT on the frequencies of various GENOTYPES and PHENOTYPES using a variety of GENETIC TECHNIQUES.
study of the distribution of genes in populations and of how genes and genotype frequencies are maintained or changed.
The branch of genetics that focuses on gene distribution and transmission through populations.
corpora geniculata
Part of the diencephalon inferior to the caudal end of the dorsal thalamus. Includes the lateral geniculate body which relays visual impulses from the optic tract to the calcarine cortex, and the medial geniculate body which relays auditory impulses from the lateral lemniscus to the auditory cortex.
One of four small oval masses that protrude slightly from the underside of the thalamus and function as synaptic centers on the way to the cerebral cortex.
ganglion geniculatum
The sensory ganglion of the facial (7th cranial) nerve. The geniculate ganglion cells send central processes to the brain stem and peripheral processes to the taste buds in the anterior tongue, the soft palate, and the skin of the external auditory meatus and the mastoid process.
herpes zoster ušní
A syndrome characterized by facial palsy in association with a herpetic eruption of the external auditory meatus. This may occasionally be associated with tinnitus, vertigo, deafness, severe otalgia, and inflammation of the pinna. The condition is caused by reactivation of a latent HERPESVIRUS 3, HUMAN infection which causes inflammation of the facial and vestibular nerves, and may occasionally involve additional cranial nerves. (From Adams et al., Principles of Neurology, 6th ed, p757)
A viral ear infection caused by the spread of varicella-zoster virus to the facial nerves. It is characterized by intense otalgia and a cutaneous vesicular eruption.
gynekologická onemocnění
Pathological processes involving the female reproductive tract (GENITALIA, FEMALE).
pohlavní orgány mužské – nemoci
Pathological processes involving the male reproductive tract (GENITALIA, MALE).
pohlavní orgány ženské – nádory
Tumor or cancer of the female reproductive tract (GENITALIA, FEMALE).
new abnormal tissue of the female reproductive system that grows by excessive cellular division and proliferation more rapidly than normal and continues to grow after the stimuli that initiated the new growth cease.
Cancer in the human female`s reproductive organs
pohlavní orgány mužské – nádory
Tumor or cancer of the MALE GENITALIA.
new abnormal tissue of the male reproductive system that grows by excessive cellular division and proliferation more rapidly than normal and continues to grow after the stimuli that initiated the new growth cease.


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|Lovingly, Kate
|The Poppy Creative
This week I found it harder to be clever.. Dreamcatchers are already little pieces of art work - so it was a bit tricky trying to do something OTHER than draw one. I do love a challenge though and I think I made the most of it!
I've been working on some design projects this week (paid ones too!) so it's been pretty busy. And I sold another TWO etsy invitations! I promise I will post them soon. Otherwise, you can check them out here


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Watch Advance Australia Free Online. Stream and Download The Full Movie Advance Australia For Free Online
|>>Watch Free: Link 1
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Where Can I watch Advance Australia For Free? Now a days there are many sites available for free to watch Advance Australia online. Now a days we prefer to watch Advance Australia online because for offline first we have to download and then watch it, but for online we can see right now.
Australia is Big. Really big. This tour and TV documentary will feature local communities across the country and the unique and interesting facets of small town Australia in a way that's never been done before. This is a new way to see the country. Our very big country called Australia. The show features Sam Pollard and his cycling companions traveling across Australia by bicycle. It's all about
"In 1997, the Nepabunna Aboriginal community near Leigh Creek in South Australia declared their land to be Australia's first Indigenous Protected Area (IPA). Ten years on, there are now 24 Indigenous Protected Areas covering close to 17 million hectares across Australia. IPAs are seen as one of Australia's great environmental success stories, and have been praised by people from around the world
. Episode 7: "THE LONEY HUNTER" GREAT WHITE SHARKS OF AUSTRALIA South Australia & Victoria (Australia) The film is a chronicle of a journey that visits every known White Shark area on the Southern Australian coast to look for the Great Whites and evidence of it's declining numbers. Along the way the team visit with local experts from Australia, to hear their stories, of a fish that has captivate
Join one of Australia's most travelled musicians, Steve Grace, as he leads a 78 concert, 4 month, 25 000km / 15 000mi road trip around Australia on a missions trip of a lifetime. Experience just about everything Australia has to offer as Steve leads his 25 person team through the thirsty outback, to Australia's golden coastlines and to some of the most remote parts downunder. Joining Steve is hi
In the opening of this picture we see in the foreground a company of Highlanders preparing for a charge on the Boer entrenchments seen in the distance. Just in advance of the Highlanders, two pieces of artillery have just been placed in position, and these immediately open fire upon the enemy. After several volleys from the battery, the Highlanders charge. They only reach a point just in advance
Scenes depicted are those of the army of Italy, and in the advance through the Alps toward the Austrian frontier. The scenes of warfare shown are: Artillery duels; bursting shrapnel and shells; soldiers charging through barbed wire entanglements in actual conflict; life in the advance trenches; scouts scaling seemingly almost impossible mountain heights, and other details.
"Payday Advance" is a dramatic comedy about a Payday Advance Store Owner, who FBI Officials suspect is laundering drug money through his business as he does philanthropic good deeds in the community. This self-sufficient, Owner, seeks for the love of his life, while frustrating the FBI agents, whose intent is to prove that all his deeds are not good.
Jorn Utzon was awarded the first prize in an international architecture competition to design an Opera House for Sydney. In 1957 he flew to Australia to begin work on the construction of the greatest building Australia has ever seen and, indeed, one of the finest achievements of modern architecture. Utzon was forced from the project in 1966 and has never returned to Australia. What defeated him
Australian sport documentary about the first ever winning of the America's Cup by a non-US country. Shows the background story of the preparation, design, construction, testing, and trials of Australia's winning yacht, the Australia II. Documents the preliminary races, elimination of British yacht Victory '83 and the final main race itself where Australia is victorious over the Americans on 26 S
WAP stands for White Australia Policy, a racist policy which limited migration into Australia into the nineteen fifties. This policy can be read as a marker of the guilt surrounding the Aboriginal genocide that had blotted white settlement of Australia since its inception. This film re-frames historic material to allow the voices of the deferred and dispossessed to speak their trauma, speaking o
There are many Free and paid sites to watch Advance Australia online . And some of sites you have to login or signup but there is also some sites where login or signup is not required to watch Advance Australia for free.
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SEATTLE, Washington - What a special anniversary this is, exactly one year since the one and only time I was let go from a job.
Media accounts of layoffs (and commentary upon said layoffs) often speak of reductions in staffing as if Something Awful has happened - a grave violation of the social contract, a cruel trampling of peoples' lives for the sake of inflating the bottom line. This is hogwash - businesses exist to provide goods and services, not to provide people a living
In my case, I speculated that the RIF was a preparatory step to my company being acquired, and that's exactly what happened. The layoffs were the right thing to do, every last one of them.
Most people would look at my situation and say that I got myself into a better place than I was in at my previous job.
* No matter how stridently labor unions and their ideological allies seem to think otherwise
Laid off - one year ago today!
Posted by Jeff at 5/15/2008 04:43:00 PM
Labels: biz


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Tonight was our monthly EBOD meeting so I thought I'd take a moment or two and give you a quick update!!
Membership & financials are strong.
As you know we now have a Land Use Committee Chairperson and the committee's first (we hope of several!) member! Thanks again to Nick Navoni & Mike Timm respectively.
And it looks like we have a volunteer to step into the Trail Ride Committee chairperson's slot - we're just nailing down a detail or two but stay tuned for that announcement also!
The next edition Boondocker is well on its way towards publishing - thanks to all the persons who made submissions!
Coming up in a week and a half (1/27/17) is the Association's Winter Quarterly General Membership Meeting being held in conjunction with SoFO's annual Sno-Fari event. The Quality Inn in West Branch is home to the event again, and the GLFWDA Winter Quarterly will be held at 5:00 PM in the Damon 1 conference room at the Quality Inn.
The Association will also present the GLFWDA Annual Awards next weekend - look for updates on who our honorees are when we recap the meeting later this month!
And there will be an update on the progress of Oakland County Groveland Township ORV Park next weekend also.
Events where Great Lakes will have a presence at this spring are:
> Jeep the Mac, April 21 & 22
> Blessing of the Jeeps, May 6
> Jeeping for a Cure, May 20
> 4x4 Fest, June 24
Member volunteers are welcome (and needed!) to assist at these events. If you're attending anyway, let us know and maybe you can give us a couple hours working the event with one or two of the EBOD members or Committee chairs!
Looking ahead, the Association is looking for a venue for their Spring Quarterly Membership Meeting. After the resounding success of our Fall Quarterly Membership meeting last November (thank you one last time Outback & Dauntless!!) we're looking to repeat that on the east side of the state! At all the clubs on the sunrise side of the mitten state here's your chance to shine!!
To all the super GLFWDA membership: thank you for 'supporting the sport'!


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Sinitta wears see through bikini top and reveals a bit too much on Celebrity Big Brother's Bit On The Side
The star realises her wardrobe malfunction after fans tweet
SINITTA revealed a bit TOO much when she appeared on last night's Celebrity Big Brother's Bit On the Side.
Wearing a crochet bikini top, she showed off some serious underboob, and at one point you could see her nipples through the tiny top.
The former pop star, 53, was oblivious to her wardrobe malfunction, until some of her fans pointed out.
One wrote: "@sinittaofficial needs to tuck her underboob back in! Escaping boobies yes your 🔥🔥! #BBOTS"
The So Macho star quickly replied: "@tina_nisbet oops ok got it"
Another said: "Can someone tell @sinittaofficial her underboob is coming out 🙈 #awkward #CBBBOTS
Too which she replied: "@StarzAndScarz oh no!"
This one tweeted: "@sinittaofficial just in case you see this... your underboob is popping out"
And Sinitta simply wrote: "@justjo74 eeek!"
The star did look good though, even though she suffered the unfortunate nip slip.
She teemed the bikini top with skin tight trousers and a black shawl.
The outfit showed off her incredible toned tum and slender pins.
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FESTIVE FAILSinitta's Chistmas present for Simon Cowell was 'confiscated by authorities' who deemed it a 'terror risk'
'I LIKE BRADITTA'Sinitta claims ex Brad Pitt has been 'calling her' and reveals the actor is a 'good kisser' on Alan Carr
SO MACHOSinitta pulls series of sexy poses on a paddle board as she steals the show on Barbados holiday
FUN FACTORSinitta's in high spirits and risks embarrassing wardrobe malfunction as she leaves Loulou's in Mayfair
SI-NEATERSinitta to broadcast surgery on her privates live on YouTube for shocking new documentary series
Fans were quick to compliment her on her figure, with one saying: "Sinitta looks better than I've ever looked in my life😂 #BBOTS #cbb"
Another said: "#Sinitta looks gorgeous #CBBUK still looks in her twenties"
Sinitta is known for her outrageous wardrobe.
She famously appeared on the X Factor wearing only pine leaves to hide her modesty, much to best friend Simon Cowell's amusement.
Got a story? Email firstname.lastname@example.com or call us direct on 02077824220


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Kolkata: Indian archery team, comprising
Jayanta Talukdar, Dola Banerjee and Deepika Kumari, is
confident of producing good results in the Archery World Cup
Grand final in Edinburgh to be held on September 18 and 19.
The trio will leave for United Kingdom on Tuesday along
with coach Purnima Mahato.
Talukdar, currently ranked five and a bronze medallist in
the recently concluded World Cup championship at Sanghai, said
"I hope we would be able to live up to the expectation in this
championship as well."
Talukdar will meet Michelle Farngilli of Italy in the
first round.
Dola Banerjee, currently 10th in the world ranking,
echoed Talukdar`s view.
"This competition would be an ideal opportunity for us to
sharpen our skill before the Commonwealth Games as we would be
competing against the best archers in the world."
Dola in the first round will have to take on higher
ranked Mospinek Justyna of Poland.
This is the first time India will be represented by three
participants in the world event.
Secretary of Archery Association of India, Paresh
Mukherjee said he was confident that India would put up a very
good show and win a number of medals including golds in the
forthcoming Commonwealth Games.
Beside Dola and Deepika, Bombayla Devi will feature in
the Indian women Recurve team for Commonwealth Games, while
the men team in this event would consist of Talukdar, Rahul
Banerjee and Tarundeep Rai.
Those who would represent India in the Compound event
include Srithar, Jijnas and Ritul Chatterjee (Men) and Jhanu
Hansda, Bhagyabati Chanu and Gaganjit Kaur (women).
All these twelve archers would also compete in the
individual events in the Commonwealth Games, Mukherjee added.


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Double your dating deep inner game should a woman call a man she dating
) and write down 3 REAL-LIFE ACTIONS you'll take this week to start turning things around. Participate in an activity you're semi-good at this week) and they should be simple (Feel like you're too shy? Begin with these steps, and before you know it, you'll start creating a better "inner game" attitude for yourself…a new hope and confidence that comes from just BEGINNING to change.Stick to them…add to them…and it will will ignite a CHAIN REACTION in your life.
This was his first encounter with the seduction community and he quickly became a protege of Jeffries who taught various techniques like Neuro-linguistic Programming (NLP).
De Angelo is recognised for teaching attraction methods that run counter to what he says most men think women want.
But fair warning: For now, do NOT worry about how you'll actually become that guy.
Just stick to imagining some ways that you'll be different once you're sharing your life with a great woman.
These methods include: Double Your Dating was the first ebook released by De Angelo, winning numerous awards including Seduction Book Of The Year 2008.
It's success led to a follow up ebook as well as CD's, DVD's, live seminars and coaching, propelling De Angelo into the limelight.How a man feels about himself deep inside — also known as his "inner game" — is his key to finding and building a great relationship.Nothing worthwhile is easy…and when it comes to dating success, it couldn't be more true.In my case, a few years back I realized that "Future Me" (that guy who's finally successful with women) would need a more easygoing attitude and to be more comfortable in his own skin.He'd need to be more willing to take risks, and to say and do things outside of his "comfort zone." Above all, he'd need a better sense of humor.His Double Your Dating ebook launched a dating advice empire that reportedly makes over million in sales each year from ebooks, video courses, seminars and other coaching for men.Tags: Adult Dating, affair dating, sex dating


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A Level Results
A Level Results Day – Thursday 16 August 2018
Y13 collection time 09.00am – 11.00am
Y12 collection time 12.30pm – 2.30pm
*If you wish for any other person (including family members) to collect your results you must give your written authorisation to the Examinations Officer BEFORE RESULTS DAY.
*Results cannot be given over the phone or by email.
Certificates will be available for collection December 2018, details will follow.
Exam Certificates are to be signed for by the named student.
*If you wish for any other person (including family members) to collect on your behalf written consent must be provided to the Examinations Officer; photographic ID will be requested on collection of certificate/s.
*Certificates are kept for one year only.
Replacement Certificates
To request a replacement certificate you must contact the appropriate awarding body (charges apply):
AQA: http://www.aqa.org.uk/help-and-contacts/past-results
Edexcel: http://qualifications.pearson.com/en/support/Services/replacement-certificates.html
OCR: http://www.ocr.org.uk/i-want-to/lost-certificates/
WJEC: http://www.wjec.co.uk/students/certificates/


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Air Conditioning
Our licensed technicians can efficiently take care of your heating and cooling system. Our trucks are well stocked so you shouldn't have to wait days to be comfortable again. We also respect you and your property on every visit.
If you ever find yourself freezing in your home or business because your heater is out of commission, you can call us for emergency repairs.
Indoor Air Quality
To help control mold and other contaminants, contact your Pruett technician about air humidifiers, dehumidifiers, air cleaners, and other IAQ products.
Air Conditioner or Heater on the Fritz?
We are locally owned and operated and have been serving Warner Robins, Eastman, Macon and surrounding areas for more than 30 years with the goal to make sure every one of our customers is 100 percent satisfied. That means providing excellent service and getting the job done right every time. Whether you need emergency air conditioning repairs, new heating installations or indoor air quality advice, your comfort is in good hands with Pruett Air Conditioning.
Very good group of guys, very polite and courteous to everybody in my family.
I would recommend them to anybody, and prices and service was way past excellent. We are a very happy customer.
Thanks for everything. What do they say? Hot Cold Baby!!!
Air Conditioner and Heater Repair.
Heating and cooling emergencies are not problems for our technicians at Pruett Air Conditioning. We stock quality Carrier parts for the most common repairs to fix your equipment as quickly as possible. Estimates are complete with no hidden fees, and your options are fully explained before the work begins.
Heating and Air Conditioning Installation
We have decades of experience installing new heating and cooling systems for homes and businesses. Whether your project is a new construction or you just need to replace an aging system, we'll help you choose the best products to meet your needs. Ask us about manufacturer rebates and other promotions that could save you money on your purchase.
Heating and Air Conditioning Maintenance
In addition to regular HVAC service and emergency repairs, we offer preventive maintenance through our Customer Care Plan. These check-ups will ensure that your equipment runs as efficiently as possible while preventing untimely system failures. Call us for details.
Why Choose Pruett?
- EPA and N.A.T.E. certified HVAC technicians
- Service for all models of equipment
- Services for residential and commercial customers
- We are a Carrier Factory Authorized Dealer
- Financing options with approved credit
- Preventive maintenance Customer Care Plan
- Products for improving indoor air quality.
- 100 percent satisfaction guarantee on all of our work
How an HVAC Upgrade Benefits Your Home
If you're thinking about making upgrades in your Warner Robins, Georgia, home, you're probably looking at renovations and additions. However, one of the most valuable upgrades in a residential property is a new HVAC system. Read on to learn how an HVAC upgrade can...read more
3 Ways to Sleep Better
Sleep is crucial to your overall health and well-being. If you're having trouble sleeping in your Eastman, Georgia, home, you may not realize the factors that could be to blame. The temperature in your bedroom, your sleeping habits, and moisture levels in the home...read more
Is It Time to Schedule an Air Duct Cleaning?
Your home should be a sanctuary where you can find relief from sneezing, coughing and other allergy symptoms. If you start experiencing those same symptoms when your AC system kicks on, you desperately need your air ducts cleaned. Homeowners in Eastman, Georgia, can...read more


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Published on: 06 Jan 2017 by eastmanvirg77
When should Kybella be administered?
Kybella in Toledo IN is similar to deoxycholic acid in a way that it helps in absorbing the fat naturally by destroying the fat cells. This is an alternative method to surgery or liposuction for treating the fat on the chin. Approved by the FDA, dermatologists and cosmetic surgeons offer Kybella for an effective way of eliminating double chin.
A large number of people who have a double chin are concerned with their appearance. During a Kybella treatment, the patient is given several injections on each visit with a need for two or three visits with a month's gap. The results from such treatment often last for many years.
Common side effects of Kybella
The common side effects of Kybella are firmness, numbness, pain, swelling, and bruising around the injection site. The numbness at the site may resolve on its own in a few days. A serious injury that could take place during a Kybella treatment is an injury to the marginal mandibular nerve that helps in control of the facial expression and this may cause an off-balance smile. This may occur if the shots were given closer to the nerve which is another reason why a doctor must be well trained and experienced with this treatment.
Communication with your doctor is the key
You must advise your doctor if you had or you are planning to get a surgery on the chin, neck, or face. The doctor will also want to know if you have any problems with swallowing, bleeding, if you are pregnant, or if you are planning a pregnancy. Also, it is recommended to communicate with your doctor about any medicines, herbal supplements, or vitamins you take.


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Post a link
to a band you've just discovered and think are really good. Here's one I found last week:
I can't stop playing You Got Pop, You Got Style, at all.
come on, I want to hear something new
slight jag
since I know him/them IRL but I really enjoyed this and maybe you will too.
Next Life
More of a re-discovery, because I heard them on a comp ages ago, but just got back into them and they're great:


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Good Charlotte singer Joel Madden took Nicole Richie and their daughter Harlow to Disney's Wolfgang Puck Grand Cafe in Orlando, Fla., on July 30. The couple ate ribs and sushi while lavishing attention on their 7-month-old girl who a fellow diner tells OK!, "is unbelievably well behaved!"
Joel, 29, and Nicole, 26, never made it to the magic kingdom, but a pal tells OK!, "They're planning to go to Disneyland as soon as Joel gets time off."
Sound off in the comments below!
Join the conversation


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You can truly learn something from just about anyone and anywhere. I say that to elude to a short video I recently watched that challenged in such a good way. I was watching a short interview of a recording artist who was giving the back story for one of her new projects. In this interview the artist talked about something she had been inspired to do to keep her life focused and strong. She made a list of things that she had to have in her life to function fully. Things that were essential to keeping her spiritually, emotionally, and physically strong. This list included many things most people would agree are essential, things like time with the Lord, time with her family, and time with uplifting people. I think we would all agree those are important things, so we should certainly be intentional about planning them into our lives.
I decided to use her concept for myself. So I too made a list of things that I have to have in my life. I put down the essentials, but then I took time to take inventory. I thought about activities that may not be essential, but they refresh me; to put it simply, they make me happier. You know, I think just as we need to be intentional about the essentials in our life, we need to be intentional about making time for things that refresh us, things that keep us inspired, and renew joy in our hearts for life.
So I reflected. I took inventory. What are things essential to keeping me strong spiritually, emotionally, and physically? What things make me 100%? Personally, I made two lists. One was for things I needed in my daily routine and the other for the things I need in my weekly routine. Yes the essentials are in there, but I realized I need to make time for the fun stuff, for the stuff that will keep me inspired. I needed some hobbies and adventures in there! So I made ANOTHER list (and all the type A personalities said "Duh, what else would you do??"). In this list I complied things that I currently do or have done that I really enjoy. Things like graphic design, painting, coffee tasting, writing, hiking, concerts/events. Then I added things that I would like try. For which I included knitting/crocheting, handwriting classes, kickboxing class, painting class, learn a foreign language. Silly, unnecessary things, but all things that help me try new things and stay inspired so I can always be at 100%.
What are some things you currently do to keep you inspired and keep you at 100%?


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The Left Cries for the Poor Little Butcher of Baghdad
The liberal media has offered Saddam Hussein more sympathy since his capture than they have offered the over 250 mass grave victims found in Iraq to date.
Today was no different.
Human Rights Watch, based in New York City, led the charge in defending the mass murdering Saddam:
Human Rights Watch, said the failure to question the witnesses was "probably the most disturbing part of the day."
"The events take us further away from the basic practices of fairness that are necessary in any trial and especially in a trial of this significance," he said.
Ibrahim's comments were "clearly provocative and disrespectful," but Abdel-Rahman was "a little too trigger-happy," he told The Associated Press.
Saddam loyalist, Democrat Ramsey Clark, didn't miss a chance to put down the new judge in the trial, demanding the trial be moved out of Iraq:
Former U.S. Attorney General Ramsey Clark, who is part of Saddam's defense team but did not attend Sunday's session, denounced the court as "lawless" and repeated calls for it to be moved out of Iraq.
"Now the court is seated without the defendants' counsel of choice. This is wrong," Clark said, speaking from New York.
The BBC has their own international lawyer who calls the trial a sham:
Saad Djebbar, an international lawyer and commentator on Middle East politics, told the BBC that the chaotic scenes meant that the whole trial was being undermined:
"I think it was a big mistake that this trial was held in Iraq because the judge, you cannot find a person, one individual today in Iraq – judge, lawyer, prosecutor who is impartial vis-a-vis Saddam Hussein. Either they are with him or against him."
Meanwhile several more witnesses testified today in the trial against Saddam Hussein:
The first woman told the court she was arrested several days after the assassination attempt and her interrogators removed her Islamic headscarf and gave her electric shocks to her head.
"I thought my eyes would pop out," she said. Sixteen other members of her family also were arrested, and seven of them were killed in detention — including her husband, who she said was tortured to death.
She added her daughter was less than two months old on the day of her arrest.
"I could not feed my little girl as she cried, there was no milk and no nursing bottle, she almost died," she said of the baby.
The man, who testified last, told the court that he was only six when he was arrested while playing at his aunt's home with cousins. At the notorious Abu Ghraib prison, guards lured him and other children with promises of apples and bananas only to tie them by the feet, he said.
The other female witness said she and 14 other members of her family, including children as young as seven months, were rounded up from Dujail.
"They tortured a young girl who was blind. Women and children were crying, there was no food and no milk formula for children," she said, sobbing. "Has anything like that ever happened anywhere in the world?"
Iraq the Model sees the antics from the defense team for what it is, pathetic.
Hat Tip C. Robinson
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