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first and formost congrats again to Ghost who is now mr.Ghost haha. thanks Mikel and Andrew for keeping the site going after a flat line. For those who check the site and have read my bio im no longer keeping my car. this time im serious. its already started to part it out. it was a seriously long journey… the longest ive ever owned a single car (2yrs) and the most fun and headache ive ever had with one. 2 clutch ,3 tasmissions 1 set of tires, multiple exhaust tickets, 2 alternators , 2 fuel pumps , countless man hrs of labor, countless hrs and late nites of tuning and learning, and 2 starters i realize its become a cancer to my pockets. Not in the sense its not worth it , but that i cant afford to keep it or get it to were i want it to be, and considered the modifications too much for me to have it run any slower than it has. The car topped out at 513hp @ 7.8k rpm on 93 oct, 29-30psi. Fuel pump leaned it out by far not safe. But i had fun. driving a 500 hp car is def a thrill . Lighting up all 4 tires in 2nd gear amazing. and saying that i dont think anyone in my crew will hit that mark again soon (please guys prove me wrong) is defiantly an achievement. the next time i hit the road it will b bigger then a 3ltr engine. lol i=I'm aiming for a g35 or a ls2 gto. we will see. for now im done tuning (as Gotooning) it'll be a hobby and a favor to my friends.
My good-bye & AppologiesPosted: August 13, 2011 by kemist88 in Announcements, Black hawk
Tags: awd, boost, cancer, dsm, eclipse, gotooning, hobby, modification, part out, psi, talon


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Despite rain, people vote in Nepal's second phase of local polls
Binod Prasad Adhikari | Updated: Jun 28, 2017 21:38 IST
Kathmandu [Nepal], June 28 (ANI): Voters in restive southern Nepal queued up at polling stations to exercise their voting rights in the second phase of local elections in three provinces of the country on Wednesday despite heavy rains. More than 6.4 million eligible voters of provinces number one, five and seven are casting their votes to choose 15,038 local representatives out of 64,000 candidates vying for the limited post for 334 local bodies. More than 1,60,000 security personnel have been deployed to ensure the security across 8,364 polling stations around the three provinces. The Nepal's Election Commission claimed that 33 percent votes were casted in early four hours after polling opened at 7 a.m. local time on Wednesday. The first phase of the local polls in Nepal was held on May 14, whereas the second phase is being held today. The final or the third phase poll will be held on September 18 in province number two. Province number two is the disruptive south plain in the Terai region of Nepal which is the home town of prominent Madhesi leaders who have been demanding for amendment in the Constitution to ensure their participation. The volatile southern plains of Nepal have witnessed bloodshed from past two years which have claimed the lives about 100 people as the protest over the constitution erupted time and again. Nepal has the constitutional time limitation till the first month of 2018 to hold remaining two-tier election of the Provincial Council and the Centre. (ANI)

subset: commoncrawl


text:
Yesh! Have been going out every day since last wednesday, and i'm still going out today. Imagine the money flying out of my pocket.. argh.. =(
This christmas eve i went watching NARNIA~! ROARRRR~ Haaaa, i love Aslan lor, voice so freaking deep and sexy. Haaaa. The four kings and queens are all crap, 'cause Aslan rules. When the witch ordered those ugly animals to cut off Aslan's fur i was so so near to exploding lor. =`(
These christmas celebrations were great, i enjoy being with everyone and YESH! i love all the pressies and cards. =) Thank you guys once again.
Guys i'm late already!! Haaaaa, tataz!


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This course is designed for individuals who need skills to prepare for a vocational pathway qualification or further foundation studies development.
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text:
A Moment of Kindness
In an effort to continue my life without too many interruptions I've begun taking public transportation to the office in the city a few days a week. In the past I would either ride the entire way or drive to the Golden Gate Bridge park and then ride across the bridge into the city. I can't drive right now so the bus is my alternative.
Last night I was standing at the bus stop in the city when I saw my bus. So I went to the curb and waved my hand. I thought the bus driver saw me but apparently he didn't and he continued past me and through the traffic light. The driver of the bus behind him saw what happened pulled over and told me to jump on. He then proceeded to weave through traffic and get ahead of the bus that passed me by. We caught up to my intended bus and I was able to get on my bus home. Would he have done this if I was not hobbling around on crutches? Who knows but it was really nice of him.
So a big thanks goes out to Joel driving the bus to Santa Rosa.


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luxury house plans
Published: 14th June 2011
Views: N/A
When you find yourself contemplating using a luxury house plan, keep in mind you need to take a look at whether you can pay for exactly what the plan and sample drawings or pictures seem to promise. Ultimately, when your finishes can't carry on, a new home won't feel as luxurious you may have hoped.
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Duration: 15 hours.This product is an online product and is a single-user, 1-year licence.
The course MS Excel 2013: Advanced is focused mainly on the creation of charts and automation of the work in the program by using macros. Besides these main topics, you will also examine the insertion of various graphical elements into worksheets, such as shapes or SmartArt graphics. You will learn to prepare a table or the entire worksheet before printing and you will familiarise yourself with the options of protecting and sharing the workbook content. You will further familiarise yourself with the usage of macros, including their creation and editing and you will also examine the options of
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text:
|Reggie Bennett
|Ring name(s)
|Reggie Bennett
|Billed height
|5 ft 8 in (1.73 m)[1]
|Billed weight
|220 lb (100 kg)[1]
|January 24, 1961
San Diego, California
Reggie Bennett (born January 24, 1961 in San Diego, California) is an American former professional wrestler most known for her work in Joshi Puroresu organizations such as All Japan Women's Pro-Wrestling.[2]
She began her career in the independent Californian circuit in 1986.[3] After making her professional debut, she was signed to the Ladies Professional Wrestling Association. Bennett participated in the LPWA Japan Title tournament during the February 23, 1992 pay-per-view LPWA Super Ladies Showdown losing by disqualification in the semi-final round.
Bennett signed with All Japan Women's Pro-Wrestling in 1994 and competed there for several years. Bennett faced Chigusa Nagayo at the Big Egg Wrestling Universe show at the Tokyo Dome on November 20, 1994.[3] She won the IWA World Women's Championship on May 15, 1995, defeating Manami Toyota.[4] At the time, Toyota also held the WWWA World Heavyweight Championship, the most prestigious title in Japanese women's wrestling, although that title was not on the line in that match. She lost the IWA belt later in 1995 to Takako Inoue. Bennett then went on to capture the All Pacific Championship by defeating Mariko Yoshida and then Kaoru Ito in a tournament on June 22, 1996, although she would again lose her title to Takako Inoue.[5] [6]
On April 12, 1997, Bennett was one of the featured speakers at a banquet honoring Terry Funk. The following night at ECW Barely Legal, she debuted as a member of Raven's Nest interfering with the ECW Heavyweight Championship match between Funk and Raven.[7]
On November 14 1997, Bennett joined ARSION,[8] forming a monster heel stable of American wrestlers with newcomer Jessica Soto, who was billed as Reggie's younger sister Jessica Bennett.[9] The duo was one of the featured teams in the Twinstar of Arsion tournament and video collection.[8]
Bennett married the Japanese musician Kenji Ishihara in August 2000. Later that year she decided to retire from wrestling, fighting Manami Toyota in her farewell match on March 4, 2001.[3] Following her retirement, her career was memorialized in the video release Reggie Bennett in Japan.[10]
Bennett also had small roles in a number of films, first appearing in Spacehunter: Adventures in the Forbidden Zone (1983). She also had a cameo role in the Sylvester Stallone film Over the Top (1987).


text:
Homestead B&B (179238)
A warm welcome awaits you at our spacious home set in its own grounds of 7 acres. We are tucked away at the end of our own private lane 300 yards from a country road on the north eastern outskirts of Burgess Hill. We''re surrounded by an abundance of wildlife including foxes badgers deer rabbits and squirrels. Our numerous free range chickens and ducks are also an endless source of amusement to our guests.Haywards Heath is only 2 miles to the north and Brighton 10 miles south. Wivelsfield main line station is 10 minutes walk with 4 trains an hour to Gatwick Croydon and London. There is also an hourly service to Lewes and Eastbourne. The town centre is about 1 miles awayOur rooms of which all are en suite consist:- Ground floor: - 1 double (or twin) and 1 single First floor: - 1 double and 1 tripleAll our rooms are attractively decorated with colour co-ordinated bed linen towels and bathrobes. Each has colour TV clockradioalarm fully stocked beverage tray complimentary bottled waters central and supplementary heating hairdryer iron trouser press ceiling fan. Broadband and wireless WiFi internet access is available in all rooms.We offer a very extensive and flexible breakfast menu including an 8 item English breakfast. Vegetarian and coliac options are available.We also have The Country View Suite - a fully self-contained ground floor private suite of rooms furnished and fitted to a very high standard specifically designed for three adults. It comprises a loungedining room with galley kitchen double bedroom and large en suite shower roomW.C. It is the ideal environment for our less mobile guests.Availability is on our usual bed and breakfast basis In addition the fully fitted kitchen area gives you the facility to self-cater for a lunch or evening meal if so required.Guests are welcome to use our mini-gym Hot tub and covered heated 32c (all year round) swimming pool.Helicopter landing facility is available.
Address: Homestead Lane Valebridge Road, Burgess Hill, RH15 0RQ
Prices From: £
Number of Rooms:


text:
Frequently Asked Questions
Oscar Wilde once said, "Be yourself. Everyone else is taken." Great man, this guy! And extremely motivating, when you think about it, for his quotation drives our entire design team for reasons which can be very questionable.We believe in being ourselves because we love ourselves so much. Hence, you get a bunch of loony tunes on your hands! Extremely creative, but crazy. Highly motivated, but bonkers. Dedicated to our work; but completely nuts.We also believe in imparting that same individuality to your websites. If it's not unique, it's not us. And, if it is us, it simply cannot be run of the mill!
- Can you help me choosing my website name and the registrar?.
- Domain name is extremely important for SEO (Search Engine Optimization). Best options are to include your main keywords of your business in the domain. We are willing to help you find best option for you business and give you as many ideas as needed upon your request.
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- Cost of domain start at $9.50 per Year. You can choose from several hosting companies such as GoDaddy, 1and1.com, domain.com, cheapnamedomain.com.
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- Our Websites are pre-Hosted on our servers you dont need to worrie about web hosting.
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- We can deliver most of the websites in 2-4 days after all of the content and pictures are delivered to us.If You dont have content and graphics we will deliver deliver your website within a week.
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Shop Announcement:
SALE - 20% off almost everything for a limited time only!
Seaside Sand Dunes and Sail Boats Nautical Picture
Shimmering sand dunes shine golden in front of a deep blue sea, on which four glittering teal-green sail boats sail, as shimmering seagulls fly in the sunshine.
The sail boats are made from very pretty flowery vintage fabrics, with pink and red, mauve and green flowers, adding a delightful touch to this pretty picture.
This picture would make a lovely seaside decoration for a room with a nautical theme, or even for a beach hut, if you are lucky enough to have one!
The picture is A4 in size, and is left unframed for you to best choose how to frame it. It will be securely packaged to ensure it will not be damaged in transit.
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text: I made an appointment with a new oncologist. I wonder what my future holds? I couldn't get in until June. I can't believe how busy all of these doctors are. It's sad, actually. Well, I guess I'm not really in a hurry, I will just happily enjoy the next few weeks of ignorant bliss, until the next phase of the science project begins!


text:
Oxidative Medicine and Cellular Longevity
Volume 2011, Article ID 143269, 5 pages
Targeting HDACs: A Promising Therapy for Alzheimer's Disease
1College of Life Science, Capital Normal University, Beijing 100048, China
2College of Arts and Science, Beijing Union University, Beijing 100191, China
3Department of Physiology and Pathophysiology, Peking University School of Basic Medical Sciences, Beijing 100191, China
4Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing 100191, China
Received 16 May 2011; Revised 22 July 2011; Accepted 23 July 2011
Academic Editor: Florian Lang
Copyright © 2011 Ke Xu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Epigenetic modifications like DNA methylation and histone acetylation play an important role in a wide range of brain disorders. Histone deacetylases (HDACs) regulate the homeostasis of histone acetylation. Histone deacetylase inhibitors, which initially were used as anticancer drugs, are recently suggested to act as neuroprotectors by enhancing synaptic plasticity and learning and memory in a wide range of neurodegenerative and psychiatric disorders, such as Alzheimer's disease (AD) and Parkinson's disease (PD). To reveal the physiological roles of HDACs may provide us with a new perspective to understand the mechanism of AD and to develop selective HDAC inhibitors. This paper focuses on the recent research progresses of HDAC proteins and their inhibitors on the roles of the treatment for AD.
1. Introduction
Alzheimer's disease (AD), including familiar AD and sporadic AD, is a progressive neurodegenerative disease and the most common form of dementia. This late-onset disorder is characterized by memory loss and cognitive impairment. The pathological features are neurofibrillary tangles (NFTs), insoluble β-amyloid (Aβ) plaques, and neuron loss [1]. According to the most convincing hypothesis at present, the "amyloid cascade hypothesis," it is believed that the accumulated Aβ peptide leads to a complex cascade of neuronal apoptosis and results in the pathogenesis of AD [2, 3]. Increasing evidence supports the notion that some genetic changes in familiar AD, such as amyloid β precursor protein (APP), presenile 1, 2 (PS1&2), and apolipoprotein E, are linked to the overproduction of Aβ [4]. Although we have known a lot about both familiar AD and sporadic AD, it is still a long way to fully understand the pathogenesis of the diseases, especially sporadic AD. Epigenetics is a branch of genetics. Epigenetics studies the gene expression when the nucleotide sequences of a gene do not change, but rather other modification factors including histone acetylation and DNA methylation [5]. The epigenetic regulation offers a new way to understand AD, especially sporadic AD. DNA methylation has been previously proved to play a role in AD, and recently several studies suggested that histone acetylation is involved in the etiology of AD [6, 7]. Histone acetylation and deacetylation are catalytic by histone acetyltransferases (HATs) and histone deacetylases (HDACs), respectively. The level of histone acetylation plays an important role in regulating the chromatin condensation and gene transcription [8]. HDACs regulate the level of histone acetylation and further affect some downstream gene expression. Abnormal acetylation of histone is involved in the pathology of AD. HDAC proteins may be therapeutical targets to treatment for AD. HDAC inhibitors have been reported to improve the memory and cognition in the mouse model of AD. HDAC inhibitors may be alternative drugs to potentially protect the impairment of cognition in AD patients. However, HDAC proteins serve a very distinct function in the brain. Therefore, the use of pan-HDAC inhibitors (nonselective HDAC inhibitors) in the treatment of neuropsychiatric disorders should be careful. To identify which numbers of HDAC family are involved in memory and learning is helpful in discovering the pathological mechanism of AD and in developing selective HDAC inhibitors.
2. Histone Deacetylase and Histone Deacetylase Inhibition
2.1. Histone Deacetylase
HDAC proteins belong to an ancient protein family in many species. In fact, contrary to what is suggested by their names, certain HDACs mainly interact with nonhistone protein. In mammals, there are eighteen HDAC enzymes (Table 1), which are divided into four classes based on their homology to yeast: class I, class II, and class IV. Among these classes, class I, class II, and class IV are zinc-dependent enzymes, whereas class III is dependent on nicotinamide adenine dinucleotide (NAD+) [9, 10].
Class I of HDACs, which consists of HDAC 1, 2, 3, and 8, primarily localizes in the nucleus where they regulate histone acetylation. Class II of HDACs is divided into two subtypes: class IIa and IIb. Class IIa includes HDAC 4, 5, 7, and 9 and class IIb includes HDAC 6 and 10. Class IIa of HDACs shuttles between the nucleus and the cytoplasm in response to certain cellular signals, whereas class IIb of HDACs mainly locates in cytoplasm. In general, class III of HDAC is referred to as "sirtuins." Class III of HDACs includes SirT1-7, which share homologous sequence with the yeast Sir2 protein; SIRT 3, 4, and 5 are mitochondrial proteins [11]. Class IV HDAC is known to have only one member, HDAC11, which contains a catalytic domain located at the N-terminus. HDAC11 seems to be closely related to HDAC3 and HDAC8 [12], and it also mainly locates in the cellular nucleus [13].
2.2. Histone Deacetylase Inhibition and Alzheimer's Disease
In recent years, a variety of HDAC inhibitors have been developed (Table 1). The pan-HDAC inhibitors widely used in clinical research are valproic acid, trichostatin A, sodium 4-phenylbutyrate, and vorinostat; these inhibitors interact with zinc-dependent HDAC protein (class I, class II, and class IV). Nicotinamide, as the precursor of NAD+, inhibits class III HDAC proteins [14].
Valproic acid (VPA), as well as lithium, inhibits Aβ peptide production in HEK293 cell transfected with Swedish APP751 [15]. VPA also significantly reduces Aβ plaque in AD transgenic mice. VPA decreases Aβ production by inhibiting GSK-3β-mediated γ-secretase cleavage of APP and alleviates the memory deficits in AD mouse model [16]. Ricobaraza et al. suggested that 4-phenylbutyrate (PBA) decreases the phosphorylation of tau based on an increase of an inactive form of the GSK-3β in Tg2576 mouse model of AD [17]. PBA reinstates memory in both young and old Tg2576 mice and reverses learning deficits through clearance of intraneuronal Aβ accumulation and mitigation of endoplasmic reticulum (ER) stress [18]. Nicotinamide, a competitive inhibitor of class III NAD+-dependent HDACs, restores cognitive deficits in 3xTg-AD mice. Nicotinamide selectively reduces phosphorylation of tau at Thr231 site and increases the acetylated α-tubulin [14]. Ding et al. found that tubacin-treated HEK cells transfected with tau significantly attenuates tau phosphorylation at T231 [19]. However, the untoward effects of pan-HDAC inhibitors limit their application to clinic [20, 21]. Tubacin and suramin are the most studied selective HDAC inhibitors; tubacin shows high selectivity for HDAC6 [22], and suramin inhibits the activity of NAD+-dependent class III SirT1 and SirT2 [23]. Here are the isoforms of HDACs, and the mainly used HDAC inhibitors are listed in Table 1.
Above facts indicate that some HDAC proteins may have a close relationship with those key proteins which are involved in AD. HDAC inhibitors may be used to treat AD by regulating the activity of HDAC proteins and phosphorylation of Tau. However, the mechanism of HDAC-regulated cellular signaling in AD pathology is needed to further investigate.
3. Acetylation of Histone and Alzheimer's Disease
Histone acetylation is involved in the gene expression through chromatin modification, and the acetylation was mainly in the N-terminal of histone H3 and H4. The cognitive deficit is one of the major clinical characteristics of AD patients. In mice, deregulation of histone acetylation is associated with age-dependent memory impairment. Aged mice display a specific deregulation of histone H4 lysine12 (H4K12) acetylation and fail to initiate a hippocampal gene expression which is involved in memory consolidation, and vorinostat-treated mice display significant increase of H4K12 acetylation and restore learning-induced gene expression [24]. More and more evidence suggests that dysregulation of histone H4 acetylation is involved in AD pathology. Kilgore et al. reported that there is no difference in H3 or H4 acetylation in the hippocampus area between 6-month-old APP/PS1 mice and wild-type mice, but a significant reduction was observed in H4 acetylation in old APP/PS1 mice. The class I HDAC inhibitors sodium valproate, sodium butyrate, or vorinostat elevate histone H4 acetylation and restore contextual memory in a mouse model of AD [25]. Similarly, Francis et al. found that there is no difference in the acetylation level of histone H4 between the 4-month-old wild-type and the APP/PS1 mouse. After contextual fear-conditioning training, the APP/PS1 mice display a reduced endogenous level of histone H4 acetylation, and the mice treated with trichostatin A (TSA), a class I and II HDAC inhibitor, had improved acetylated histone H4 level and were displayed hippocampal CA3-CA1 long-term potentiation (LTP) [26]. Ricobaraza et al. reported that the acetylation of histone H4 is decreased in the 16-month-old Tg2576 mouse brain compared with nontransgenic controls, while there is no difference in H3 acetylation. Phenylbutyrate, a class IIa HDAC inhibitor, ameliorates the cognitive deficits in Tg2576 mice and increases the neuronal acetylation of H4 and the expression of synaptic plasticity markers including GluR1, PSD95, and MAP2 [17]. What is more, in Tg2576 mouse model of AD, the phenylbutyrate restores the dendritic spine density of hippocampal CA1 pyramidal neurons and significantly increases the expression of plasticity-related proteins like the NMDA receptor subunit NR2B and the synaptic scaffold SAP102 [18]. Taken together, histone acetylation H4 is involved in the pathology of AD, and HDAC inhibitors may alter some important gene expression through regulating the histone acetylation.
4. Histone Deacetylases and Alzheimer's Disease
HDACs influence the level of histone acetylation, and HDAC inhibitors upregulate histone acetylation level and improve memory and learning. The HDAC inhibitors affect the activities of the proteins that play an important role in AD, like Aβ, GSK-3β, and tau protein. GSK-3β, as a main tau phosphokinase, is linked to several mechanisms involved in AD. Increasing evidence suggests that Aβ induces hyperphosphorylation of tau though the activation of GSK-3β [27, 28]. Therefore, inhibition of Aβ-induced deficits of histone acetylation and hyperphosphorylation of tau is helpful to treat AD. HDAC inhibitors downregulate HDAC activity and thus increase the acetylation level of histone. At present, however, most available HDAC inhibitors are nonselective for HDACs because it is not fully understood which subtypes of HDACs have effects on development of AD. Identifying which subtypes of HDAC family members are involved in the pathology of AD is needed to further investigate, specifically, impairment of memory and learning.
4.1. Class I HDAC
Mice overexpressing HDAC2, but not HDAC1, result in decreased synaptic plasticity, synapse number and memory formation, and vorinostat could rescue the synaptic number and learning impairments in HDAC2-overexpressing mice. Generally, HDAC2 negatively regulates learning and memory [35]. Akhtar et al. demonstrated that in mature neurons the upregulated level of HDAC2 affects the basic excitatory neurotransmission, implying that HDAC2 may play a role in synaptic plasticity [36].
McQuown et al. found that HDAC3-Flox-modified mice (deletion of HDAC3 in the hippocampus of CA1 area) or the mice treated with RGFP136 (selective inhibitor of HDAC3) increase histone acetylation and significantly enhance long-term memory, and the expression of the genes of nuclear receptor subfamily 4, group A, member 2 (Nr4a2) and c-Fos is implicated in long-term memory [37]. Besides, Bardai and d'Mello suggested that HDAC3 is a protein with strong neurotoxic activity, and the toxic effect is cellular selective. HDAC3 is directly phosphorylated by GSK-3β, and inhibition of GSK-3β protects against HDAC3-induced neurotoxicity [38].
4.2. Class II HDAC
HDAC6, as a cytosolic enzyme, catalyzes several nonhistone proteins, such as tubulin and HSP90 deacetylase [39, 40]. HDAC6 protein level in AD brains is significantly increased in cortex and hippocampus compared with the normal brains. Tubacin (a selective inhibitor of HDAC6) attenuates site-specific phosphorylation of tau, suggesting that HDAC6 plays a role in the AD [19]. The selective inhibition of HDAC6 dramatically enhances mitochondrial movement in hippocampal neurons. GSK-3β may be involved in the active regulation of HDAC6 by phosphorylation pathway. Therefore, abnormal mitochondrial transportation could be resulted from the misregulation of HDAC6 by GSK-3β [41]. Besides, oxidative stress is the main pathological feature of AD, and selective inhibition of HDAC6 protects against oxidative-stress-induced neurodegeneration and promotes neurite outgrowth in cortical neurons [42].
HDAC4 is mainly localized in the cytoplasm of brain tissue, and abnormal expression of nuclear-localized HDAC4 promotes neuronal apoptosis while inactivation of HDAC4 suppresses neuronal cell death [43]. Therefore, HDAC4 may play an important role in nerve function.
4.3. Class III HDAC
Gao et al. found a significant reduction of SirT1 in the parietal cortex of AD patients compared with the control, and the accumulation of Aβ and tau in the AD patients may be associated with the loss of SirT1 [29]. Julien et al. suggested that the mutant mice with the lack of SirT1 show impairment in memory and synaptic plasticity, and SirT1 modulates synaptic plasticity and memory formation partly via the way of upregulation of miR-134 [30]. Therefore, SirT1 could be a target for the treatment of neurodegenerative disorders. Additionally, overexpression of the NAD+-dependent deacetylase SirT1 in a mouse model of AD reduces the production of Aβ and formation of plaques through activating the transcription of gene encoding the α-secretase ADAM10. SirT1 also regulates the Notch pathway, which repairs neuronal damage in brains [31].
The level of α-tubulin acetylation is known to play an important role in microtubule stability and SirT2 decreases the level of α-tubulin deacetylation [14]. Taylor et al. suggested that inhibition activity of SirT2 deacetylase reduces total cholesterol in primary striatal neurons [32]. The above facts hint that Sir2 is involved in the pathology of AD.
Kawamura et al. found out that RNAi-mediated SirT3 knockdown increases mitochondrial reactive oxygen species (ROS) generation in mouse fertilized eggs, and the mitochondrial ROS generation is accompanied by the p53 upregulation in SirT3-knockdown mouse embryos [33]. Additionally, the primary cultured mouse cortical neurons treated with NMDA induce massive ROS production as well as the increase of mitochondrial SirT3, while overexpression of SirT3 significantly reduces the mitochondrial ROS generation [34]. Therefore, the SirT3 appears to play a role in the protection of the nervous system against excitotoxicity.
5. Summaries
AD is one of the most common forms of dementia. Currently, the pathology of this disease is not fully understood. "Amyloid cascade hypothesis" states that the increased Aβ causes the disease progress, such as cognitive deficits, memory impairment, and neuron loss. Accumulating evidence supports the view that the HDAC proteins may be involved in its development. The HDAC proteins may regulate the level of histone acetylation and then alter the expression of some important genes which are involved in the memory and cognition and pathology of AD. HDAC inhibitors may ameliorate cognitive deficits and memory impairment in AD animal models. The potential pathways of HDAC inhibitors reversing Aβ-induced neurotoxicity may lie in that (1) HDAC inhibitors inhibit Aβ-induced hyperphosphorylation of tau protein; (2) HDAC inhibitors may regulate the expression of important genes that participate in the learning and memory (Figure 1). However, many issues need to be resolved before these inhibitors can be used to treat AD. For example, it is not yet clear which subtypes of HDACs are associated with the AD and which selective HDAC inhibitors would be effective to treat AD. Further researches are needed to clarify the exact role of HDAC proteins and to develop their selective inhibitors in the pathology of AD.
This research was supported by Project 31071512 supported by the National Natural Science Foundation of China and by the Funding Project for Academic Human Resources Development in Institutions of Higher Learning under the Jurisdiction of Beijing Municipality (PHR(IHLB)) (PHR20090514).
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We are really excited to be going to Singapore for this all out Burgundy love affair hosted by Allen Meadows of Burghound.com and jointly put on by Curtis Marsh of www.thewanderingpalate.com and Singapore's Hermitage Wine. Hosted at the St. Regis hotel, there will be lunches, dinners and classes filled with Pinot and Chardonnay. Master classes include guided tastings by Allen Meadows on Domaine Leflaive & Domaine Ponsot and Decanter's Andrew Jefford on Domaine Leroy.
A sure bet that my head will be reeling with information and good wine, I'm also looking forward taking cat naps at the pool while enjoying Singapore's warm humid weather.


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Sunday, January 14, 2007
General Growth Properties' New Downtown Guru
1 comment:
Me neither.
The article's title "Columbia Seeks Inspiration" is putting words in our mouths. "GGP Seeks Inspiration" may be more apropos.
Also, somewhat erroneous was the line "The public has consistently said it expects developers to provide art and cultural venues in return for gaining density". Which public? It makes it sound like we, the public, are in favor of more density. Did I miss that vote? Last time I checked, the public, as represented by our elected officials, have not made any formal statement that we're seeking increased density in Columbia.
We do already have Merriweather, the Rouse Performing Arts Center at HCC, Toby's, many village centers, school functions, lakefront performances, and many restaurants that provide live performances, too. Art and culture are plentiful here.
Why do some want to paint over the Mona Lisa that is Columbia's existing beautiful, well balanced, non-congested town center with the fat magic markers of urban sprawl and hyperdevelopment?


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The Mark Twain House & Museum
There are presently no open calls for submissions.
"Humor is mankind's greatest blessing."
-- Mark Twain
Welcome to the 5th Annual Mark Twain House & Museum's Royal Nonesuch Humor Writing Contest for writers of all ages and from all corners of the globe!
We recognize that Samuel Clemens began writing at an early age, and so to encourage other young authors we welcome submissions in two categories:
- Adult (age 18 and over at time of submission) at $23 per submission, and
- Young Author (age 17 and under at time of submission) at $10 per submission.
Submission fees go toward the preservation of The Mark Twain House & Museum in Hartford, CT. This contest is a whole new way to support Mark Twain's legacy. We thank you sincerely!
Submission deadline is Sunday, July 15, 2018. Word limit is 7,000 words.
Submit your original humorous essays and stories for a chance at a cash prize, and best of all - bragging rights!
"If Mark Twain were alive, he'd be happy about this contest, because he'd win it." - Andy Borowitz


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A healthy 401(k) account balance changes everything.
Don't look now, but if you check your account and compare it with what you had in January 2004, you should have at least 50 percent more money.
A $100,000 account balance roughly 31/2 years ago should be about $150,000 by now.
A diversified mix of small cap, large cap value, foreign stock, bond and even a few specialty funds thrown in would have generated an annual rate of return of at least 12 percent. Throw in three years of annual 401(k) contributions for good measure, and you're sure to be 50 percent ahead of where you were just a short while ago.
The smug sense of satisfaction we experience from the ethereal beauty of our 401(k) balances is priceless. The irony of the 401(k) phenomenon is that the total of $3 trillion we have all saved in these plans is never counted in the savings rate statistics we continually read about.
Lately, we have been bludgeoned by the financial press into believing that Americans actually borrowed last year at a rate exceeding their savings rate. Not so. Those statistics include just what people deposit in banks. Does anyone save in banks anymore? It's so 1970s.
Ken Fisher, a local money manager, points out in one of his e-mail solicitations that the U.S. savings rate is actually the highest in the world. The negative "official" U.S. savings rate excludes most of what constitutes an increase in savings in this country. It excludes any contributions to retirement plans, any capital gains on stocks, any increase in home equity, any increase in value of a closely held business, you name it.
Savings statistics exclude so much wealth-building that they amount to nothing more than junk science. Fisher's beautiful example would be Bill Gates. In the government's eyes, Bill never saved a dime while he amassed more than $50 billion.
Foreign countries whose savings rates are supposedly greater than ours have financial institutions that trap their populations into having to deal with middlemen.
A look at the comparative savings rates illustrates what a great opportunity we have here compared with other countries.
Japan has a high savings rate because saving is part of the culture. Fewer people own their own homes or even much in the way of stocks. They deposit money in savings accounts, and the banks turn around and buy equities and real estate. In Europe, the same thing happens to a large extent. These other countries have saddled their populations with a collection of middlemen, namely banks.
Remember Robert Vesco and Bernie Cornfeld? They may have been crooks, but they introduced mutual funds to Europe in the 1960s, and for this blasphemy they were ridden out on a rail.
When it comes to real estate and home ownership, nothing comes close to the opportunities we have in this country. Ever wonder why houses and buildings in Mexico take so long to build? Because there is no mortgage industry to the extent that we enjoy one here. People have to build their homes as they manage to save the money for materials.
For this reason, Mexico has one of the highest per-capita savings rates of the industrialized countries -- that is, if you're counting only what flows into bank accounts.
Beginning about 25 years ago, with the advent of money market funds and mutual funds popularized by 401(k) participation, we started to do an end run around the middlemen in the financial services industry.
Buying stocks and bonds directly or through mutual funds was a far more effective way to generate wealth and avoid what was typically about a 3 percent to 5 percent "spread" for the banks and "loss" to the public.
When gazing lovingly online at our 401(k) account balances, we need to remember not to confuse brains with a bull market. The recent 50 percent increase in our assets is terrific. The system works, but as Chairman Mao always said, "One step backward, two steps forward." We should be prepared for the inevitable short-term correction and optimistic about the long-term results.


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Getting Started
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Photo form Flying Kites fundraiser, Sarah Winchester
So I seem to have checked out of this blog for the summer. Sorry. I have been focusing on one or two clients, pulling together my catalogue of images for sale (available soon, I swear), and spending lots of time with the kids and the hubby at the beach. Any beach. Basically we are beach house whores. If you invite us we will come. :)
But on to more interesting matters. My job as a photographer is wonderful. I get to do what I love, make beautiful, and hopefully sometimes compelling images, but an added extra is that I get to meet some of the most interesting people, doing amazing things. Enter Flying Kites. This spring and early summer I did a few photo shoots for this non-profit, and their mission really drew me in. Based out of Kenya and Boston, the Flying Kites organization runs a school, orphanage and large farm which provides food for the school and home. In their words:
At our site in Njabini, we run a primary school for orphaned and critically-poor students. We work in partnership with the Ministry of Education to offer the national Kenyan curriculum while supplementing it with international curricula to ensure that students have access to a wide-range of material, learning skills and techniques, a health program and all of the tools they will need to compete on a global stage.
We provide high-quality care to orphaned children who had no safe alternative for care, in addition to vulnerable children who were removed from dangerous living circumstances.
The majority of children who come to live at our home have previously suffered from ill health and malnutrition, and early efforts to combat stunting require a holistic approach to intervention. As part of our commitment to health and sustainability, we cultivate large farms on both of our Njabini sites to provide fresh produce for our home and school.
And that is just the blurbs from the website. You must go over to the site and check out more. I was introduced to Flying Kites when the Executive Director, Leila Chambers asked me to do some head shots for their Boston based team. She and her husband Mike, are both very kind, a little quiet at first, and completely unassuming for all the amazing work they do...I mean Mike has done multiple expeditions to Mt. Everest! I also happily donated my time to photograph their fund raiser a few weeks ago and became more enamored with their cause. They are working on buying an additional 4 acres adjacent to the school , which will allow both the school and the orpahanage to be completely food self-sufficient! How amazing it that?!?!?!
Here are some photos from the school and farm from the Flying Kites Facebook page.
Here are some of my photos from the fundraiser. A great time, for a great cause. I brought my husband along with me and we were both so moved we agreed to sponsor a student. Kind of like the good old "sponsor a child." Who can't contribute $30 a month? I spend more at Starbucks in a month. This is Joseph, whom we are sponsoring.
Leila beaming about the school.
My hubby pledging a sponsorship. I was photographing when the pledging was going on, but we totally had one of those telepathic conversations, communicating without speaking, and I was thinking, we MUST be apart of this, when I saw his hand shoot up from the corner of my eye.
Right now they are working on sponsorship for Brian. They have about half of his scholarship raised, but if you are looking for a way to get involved this is a great and easy way, just click here for details. Then you will be lured in and wanting to go and volunteer at the school and take a safari with them. I am already plotting the time when we can do this...
Again, click here if you would like to get involved. They even have a level as little at $12 a month.


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ERIC Number: ED556220
Record Type: Non-Journal
Publication Date: 2013
Pages: 205
Abstractor: As Provided
Reference Count: N/A
Hip Hop Culture's OGs: A Narrative Inquiry into the Intersection of Hip Hop Culture, Black Males and Their Schooling Experiences
Buchanan, Ian P.
ProQuest LLC, Ed.D. Dissertation, University of Missouri - Columbia
Using a critical race lens, this narrative study employs a focus group design to explore the intersections between black males, hip hop culture and schooling experiences. To provide a sociocultural grounding, this study first reviews the research literature around hip hop culture.s sociocultural development and its impact as a culture force that contributes to both dominant narratives and counter narratives around black male students in the hip hop generation. This overarching purpose of the research study is to explore the ways that black males. engagement with hip hop culture might inform liberatory educational outcomes. Using the composite counter-storytelling methodology, this research study synthesizes the participants. experiences and perspectives around the intersections black masculinity, schooling and hip hop culture. Finally, as it relates to schooling and school leadership, this research outlines the possible implications and recommendations that emerge from the findings. One of the primary implications of this research is that it can inform culturally responsive and antiracist pedagogies that lead to increased self and community agency for boys of color. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com/en-US/products/dissertations/individuals.shtml.]
Descriptors: Popular Culture, African Americans, Males, African American Students, Cultural Influences, African American Culture, Masculinity, Culturally Relevant Education, Educational Environment, Social Justice, Educational Methods, Student Experience
ProQuest LLC. 789 East Eisenhower Parkway, P.O. Box 1346, Ann Arbor, MI 48106. Tel: 800-521-0600; Web site: http://www.proquest.com/en-US/products/dissertations/individuals.shtml
Publication Type: Dissertations/Theses - Doctoral Dissertations
Education Level: N/A
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Language: English
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Issues and News that concern, that will affect INDIAN Medicos, Doctors and others in the medical profession specifically and Indians at large.
October 31, 2011
Docs to spend more time with patients soon
The Medical Council of India (MCI) may soon specify how much time doctors should spend with their patients so that the regimen of medicines being prescribed to them is clear. A recent World Medicines Situation 2011 report brought out by the World Health Organization (WHO) — as reported by TOI first — had recently said that doctors, on an average, in developing countries spend less than 60 seconds in prescribing medicines and explaining the regimen to their patients. Consequently, only half of the patients receive any advice on how to take their medicines and about one-third of them don't know how to take drugs immediately on leaving the facility. Union health minister Ghulam Nabi Azad said on Friday that the government proposes to issue an advisory to the MCI to disseminate appropriate instructions among all registered medical practitioners. According to WHO, the dispensing process greatly influences how medicines are used. The WHO database shows that the dispensing time is a minute. "In such circumstances it is not surprising that patient adherence to medicines is poor," the report said. Azad said, "The doctor population ratio is not favourable in our country. Hence, there is tremendous pressure on the doctors serving in public sector hospitals. This may be the major reason for patients getting less than adequate time for consultation." MCI's own assessment says India has just one doctor for 1,700 people. In comparison, the doctor population ratio globally is 1.5:1,000. MCI has set a target to have 1 doctor for 1,000 people by 2031. The assessment note, available with TOI, also looked at the situation in other countries. Somalia has one doctor for 10, 000; Pakistan has 1:1,923 and Egypt 1: 1,484. China's doctor population ratio stands at 1:1,063; South Korea 1:951; Brazil 1:844, Singapore 1:714, Japan 1:606; Thailand 1:500; UK 1:469; the US 1:350 and Germany 1:296. Kathleen Holloway from WHO's department of essential medicines and pharmaceutical policies said, "Irrational use of medicines is a serious global problem that is wasteful and harmful. In developing countries, in primary care, less than 40% of patients in public sector and 30% of patients in private sector are treated in accordance with standard treatment guidelines." The report cites, only about 60% countries train their medical students on various aspects of prescribing medicines and only about 50% require any form of continuing medical education. The basic training for nurses and paramedical staff, who often do a bulk of prescribing, was even less — only about 40% of countries give them any basic training on how to prescribe. The report shows, though around 80% of all prescribed medicines are dispensed — usually, they are done by untrained personnel — and as many as 20%–50% of medicines dispensed are not labelled. WHO feels many countries are making relatively little investment in promoting rational use of medicines. The report had also said that two-thirds of all antibiotics are sold without prescription through unregulated private sectors. Low adherence levels by patients are common and many patients are taking antibiotics in less than the prescribed dose or for a shortened duration — like three instead of five days. Link: Original Article
Posted by Prahalathan KK
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I finally weighed Lada today. He weighs 104 grams. He came to live here 4 months ago today, more or less, and was 5 weeks old at the time, which makes him… just shy of 5,5 months old today. Apparently they are usually fully grown at around 6 months old.
He seems so small compared to Tanita!! Tiny little big-ears. :-)
3 months ago


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Nine Hats is a recently-introduced second wine from Long Shadows. Clearly this is great juice, though it is, inevitably, a bit of a mishmash blend. Tannins are a little rough, but as a $25 red this has plenty of high-priced flavor.
Paul Gregutt is a Contributing Editor for Wine Enthusiast magazine, a founding member of the magazine's Tasting Panel, and reviews the wines of Oregon and Canada. The author of the critically-acclaimed Washington Wines & Wineries—The Essential Guide, he consulted on the Pacific Northwest entries in current versions of The World Atlas of Wine and The Oxford Companion to Wine.Email: firstname.lastname@example.com.


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Archive for December 2, 2009
DEVELOPMENTS (Dec. 1, 2009)
New Kind of Predator
As 4GWAR reported in its initial posting, U.S. Customs and Border Protection (CBP) will unveil its new maritime Predator B unmanned surveillance aircraft next Monday, Dec. 7. CBP Assistant Commissioner Michael Kostelnik will take delivery of the first Predator maritime variant at the Gray Butte Flight Operations Facility of Predator maker General Atomics in Palmdale, Calif.
Kostelnik will be joined by Admiral Thad Allen, the Coast Guard's commandant, and the man behind the Predator: General Atomics Aeronautical Systems Group President Thomas Cassidy Jr. CBP and the Coast Guard, both Homeland Security Dept. agencies, have been working closely for more than a year to develop an unmanned aircraft that can patrol U.S. waters. (see Nov. 8 posting in Homeland Security).
The maritime Predator variant will be known as the Guardian Unmanned Aircraft System (UAS).
Drones over England
Police in Essex, England are looking at adopting unmanned aerial vehicles (UAVs) used by the military for surveillance in Afghanistan to combat illegal immigration and drug smuggling, according to the Daily Gazette. The news site says BAE is looking into adopting the HERTI for border and coastal patrol and the GA22 for hovering over major events.


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It was a cold, dull and damp day in Leicester last Friday but I was determined it wouldn't spoil the afternoon. A friend had come to stay for the weekend and I was going to show her around Leicester. I've never been hugely fond of the city, feeling a far greater affinity with the south of the country, but, on Friday, I saw it through someone else's eyes for the first time and realised that it's a far more interesting and friendly place than I ever gave it credit for.
We went to the cathedral first. Now I've written about the cathedral before: about what it means to me and why I think it is fit for Richard III, but things have changed. The way I feel about it hasn't changed and nothing has changed that would be perceptible to the casual visitor, but it has changed. It's stepped up.
My friend's first reaction was to exclaim how homely she found the cathedral. It's a warm and welcoming space and now, having stepped up to meet the coming challenge of caring for the remains of the last Plantagenet King, it is more so than ever before. There are more people to meet and greet you as you enter the church, to offer assistance and to show you around. They now offer free tours of the building to meet the increasing demand of tourists wanting to know more about it. And, most surprising of all, there's a "pop-up" café in the south aisle. This isn't a permanent fixture but has existed in some guise for a while now. Since the announcement that Richard III had indeed been found and would be laid to rest within the cathedral, they've opened the café every day. But, this is no ordinary café.
When we arrived there were quite a few people already seated at small tables adorned with pretty tablecloths. There were none free. A kindly gentleman asked us if we'd like a drink and set about making us a pot of tea. Once he'd filled a tray with the tea and some very dainty tea cups and saucers, we turned around to find someone had produced a table and chairs, complete with pretty tablecloth, seemingly out of thin air. People bustled about offering refills, making more tea and coffee, and serving some excellent looking home-made cake. Nothing about this is that unusual until you realise that we weren't asked for any money. On the table where the drinks were being made was simply a small bread basket for donations should anyone have felt so inclined.
When we made our way to the Richard III memorial stone there was a small crowd of visitors around it listening with rapt attention to a cathedral volunteer as she talked about the King. There were white roses placed by the memorial and I know the cathedral has seen a steady stream of visitors bearing more white roses in the last week or so. Some people come to view the church, some to view the memorial, some simply to pay their respects. All are welcomed.
We went to the Guildhall next and joined a small queue to view the exhibition – Richard III: Leicester's Search for a King. We didn't have to queue for long and the wait was alleviated by the easy banter of the lady who was controlling the queue. She was friendly and obviously very proud to be part of such an important event. We were given leaflets to read and then, once inside the exhibition, left to wander through at our own pace.
As someone who has avidly watched the press conference and read all the news I could get my hands on regarding the discovery of Richard III, I didn't read all the information there but, considering the short timescale for putting the exhibition together, it is very impressive. It's even interactive. For me the most interesting thing was being able to stand in front of the horizontal screen showing an image of the skeleton. You could touch various points on the screen and more information was then displayed with further photographs. It was very well done and was like having the real skeleton laid out in front of you. Everybody viewing the exhibition seemed to be engaged and interested. Most of all, they were enthusiastic.
The exhibition is housed in a modern extension of the Guildhall, but we also explored the old part of the building. It's shocking to think that I've lived in Leicestershire since I was 5 years old and never been inside the Guildhall. It is a fascinating building, the Great Hall having been built around 1390. It has everything you might expect from a building of its age: lots of wooden beams, creaking stairs and floorboards and nothing is straight. It's a wonderful space and is still fully used as a venue for music and theatre as well as weddings and such like. If you're brave enough, you can peer into the Victorian police cells. I did this without realising there was a light you could switch on first and completely freaked out when I saw a shadowy figure seated inside. I don't usually scare easily but these took me somewhat by surprise!
Venturing back out into the cold we made our way to the Jewry Wall – a large section of wall that was once part of the Roman town's public baths. I haven't been up close to it since I was at school and was surprised by the sheer scale of it. It doesn't look like much from a distance but up close you get a real sense of just how huge it must have been. Right next door to the wall is a small church: St Nicholas. This church has a very long and complicated history and is somewhere I have never visited. The external brickwork is interesting because it's obvious that some Roman bricks have been used in its construction. We were especially lucky to find it was open so we stepped inside. The interior is quite dark but rather beautiful. A gentleman who appeared to be cleaning the chancel looked up and said something like, "You won't find him here!" At any other time this might have seemed a little odd but we knew exactly what he meant.
Wandering around the city with my friend she reminded me to look up. Leicester is a modern city with modern shops and some very modern architecture; however, if you look up and venture away from the main shopping areas there is much to see. A lot of Georgian and Victorian architecture, some of it quite impressive, can be found all over the city but behind some of the façades and round unexpected corners there is still evidence of a much older city.
We spent the evening in one of the most modern attractions, Leicester's Curve Theatre. It is unlike any other theatre and has no traditional backstage area. The theatre is in the centre of the building and at the end of each performance they raise the walls separating the backstage area from the foyer, thus revealing some of the mysteries of the stage. It is a wonderfully versatile and creative place that not only hosts touring productions but produces new works too. Its modernity does nothing to impede its sense of community and it's just as important to the city as the remains of the Roman baths.
The impending reinterment of Richard III will bring a whole new dimension to Leicester. It will bring more people to the city and raise Leicester's profile not just in Britain but worldwide. As for the cathedral: I mentioned that I thought it had stepped up, and for me the most important way in which it has done this, is by not changing what it is that makes it such a special place. They continue to do all those things that make people feel welcome; they just now do them on a slightly larger scale.
That Richard III will change Leicester is inevitable. But, I'm confident that he will never change Leicester people. We will continue to be a diverse and multi-cultural community. We will also continue to make visitors feel welcome. Whether that's by sharing our knowledge and generosity in the cathedral, by encouraging people to share in our heritage, or simply by exchanging some banter in the shops, market or museums, I am sure that our friendliness will prevail.
UPDATE: Photos taken by my friend on our Leicester tour can be viewed on Flickr here.


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Ah that was one awesome idea i tell you :) really seems to be working fine as well. I was trying same method but without any rs. I though may be doing it with getting Id thru server $_GET id then may be subtract or add totalrows. haha.
Well you got it right. Appreciate it!
Thanks a lot .. God Bless You


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An edition of the Tyne Tees Television Close Up series on the 1st Newcastle Festival which ran between the 3rd and 18th October 1969. The film features a number of professional and amateur musicans perfoming, often in Eldon Square . Some of those featured include Jake Thackray and Richard Stilgoe as well as the jazz fusion group Colosseum performing at Newcastle City Hall.
An amateur film of the official opening of Ralph Gardner High School, North Shields by J W Forsyth (Chairman of Tynemouth Education Committee), 5 June 1935; showing the staff of the boys' and girls' schools with head teachers Duncan Snowdon and Florence Bell, the arrival of the guests, the unfurling of the flag and the opening speeches. Footage also includes a prize giving ceremony.
Professional film that records the visit of a young Queen Elizabeth II and Prince Philip to locations in Tyneside on October 29th 1954, including Monkseaton, Tynemouth, Newcastle and Gateshead. The film contains many good scenes of crowds, parades and views of areas of Newcastle since demolished, including Ellison Place, part of Blackett Street, and the old Royal Arcade in Pilgrim Street.
A sponsored film by Turners Film Productions that records the launch of the T.T. "Belgulf Progress" tanker from Furness Shipbuilding Co. Ltd, Haverton Hill, Stockton-on-Tees, on Saturday 13th September 1958. The film follows the VIPs boarding a special train to the launch from Kings Cross railway station in London, the launch ceremony, the return of the "Begulf Glory" to the River Tees.
An amateur film made by Alan Wharram which shows the preparation and parade of floats taking part in the Lord Mayor's Parade in Newcastle, in 1982. The film begins with views of parade members and floats preparing to leave and them travelling through the streets of Newcastle. The film ends with crowds dancing infront of the Civic Centre and the Lord Mayor of Newcastle handing out prizes to parade winners.
This amateur film records the commemorative Victory Parade that took place in central Newcastle upon Tyne on 8th June 1946. The parade includes men and women in the Royal Air Force, Army and Navy, auxiliary forces, voluntary and civil defence services (for instance, the Land Army), and North East industries, along with the Allied and Commonwealth forces in World War Two. Civilian representatives and floats also celebrate the role of The People's Theatre, Reyrolle, and the coal industry (soon to be nationalised), as well as military and North East history. A firework display closes out the day. The film was a Newcastle & District Amateur Cinematographers Association (ACA) production.
Miscellaneous film shot between the 1930s and 1960s, which features lawn bowls matches, a 1938 wedding and holiday film footage of the Lake District. This film is part of the Newcastle & District Amateur Cinematographers Association (ACA) collection.


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Mass Icon by BNP Design Studio
Mass Icon by BNP Design Studio, COLLC0148. This image is protected by copyright law and may not be used without a license. No free use allowed. #COLLC1616027
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We almost forgot the important things among all this storm nonsence
McDonalds are to stop serving Heinz ketchup
That's the joke.
Honestly, I think I'm wasted on here sometimes.
- blimeycharlie, japes, JustJay, gonad, and El_Goodo this'd this
It's a pun, or play on words, based on the fact
That "source" and "sauce" are pronounced the same way.
I thought she'd need cheering up
waht with her house having blown down and everything.
- TheWza this'd this
That's got to be a mindbogglingly big contract.
Imagine how many millions of gallons McDonalds must have bought each year. Did you know that when they bring back the McRib, it impacts international pork prices?
Thought that at first but they don't use Heinz in all but two US states following a 1970s tomato shortage.
Internationally it's a big account loss for Heinz sure but they're big enough to take it (hell it's come about due to a closer link with BK) and it could actually strengthen the ketchup market long-term if McDs continue to need a big international supplier.
it's only $3bn pa or something globally
biggest in Europe, generally 'local' brand driven (tomatoes being perishable) - so there's an understandable perception in the UK that it's a big deal when it's probably not
- moousee this'd this


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Consultant Architect
Stephen Potts
Architect. Director and CDM Principal Designer
Mark Druery
Andrew Lee
We Are A Collective Of Brilliant Specialists
We Love Buildings And We Love To Build
Sycamore Place is a new residential development in a desirable location close to the historic City Centre of York.
The design principle for the new dwellings is to create an elevation treatment and material palette which are both respectful of the existing Victorian terrace and Conservation area whilst using contemporary form and detailing to create a modern contemporary interpretation of the traditional facade.
These are homes for the future in an historic context.


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Almost another week has whizzed by and I haven't written anything since I got home from Croatia. This is due in part as the day after I returned from my trip away I started work on another job and have been a bit busy with that, and also due to the fact that I haven't done anything worth writing about. So much for early retirement, I'm working on my 8th job since February! Also, I feel a bit like the last few weekends have been chock-a-block with Easter BBQ's, Wondrous Royal weddings and trips abroad, so subsequently I'm a bit tired out. I'm not complaining at all just saying that sometimes it nice to be lazy and not feel like you have to rush around all the time. In fact we have been so lazy this weekend that we have driven everywhere. We even drove 1.5 minutes up the road this afternoon to collect a take away coffee. I'm not proud of this fact at all and certainly this is not a good move for 2 people who are rather too rotund for their own good, but at least it justified buying a car. Sort of.
As well, as collecting a small mocha, while we were out we also collected a lovely Grey Mullet for our tea from our friends at Fin and Flounder on Broadway Market. We have never cooked this at home before but I have to say it was a marvelous and will rate it a high 8 fish bones out of a possible 10. Its a very meaty fish so to speak, but does have rather a lot of bones, so beware. When I was a child I got a fish bone stuck in my throat and had to be taken to Stoke Mandeville Hospital to have it removed by a nurse with an extremely steady hand and a pair of the longest tweezers known to man. Thus I am actually rather wary of all fish products.
Grey Mullet with celery and yellow peppers
Roughly chop 2 x celery stalks/sticks and one small yellow pepper.
Add this to the cavity of the fish (washed by the monger) along with some dill tops, lemon thyme and wedges of lime.
Season the fish and vegetables with salt + pepper.
Place on a baking tray wrapped in foil and bake in a low oven for around 30 minutes (ours was a large fish).
Remove the foil and bake for a further 10 minutes at a higher heat.
Serve with a salad and try not to choke on the bones.


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Thursday, June 15, 2006
LO a day
Ok, I've agreed to do a "layout a day" challenge for Leaving Memories! Sounds like fun! Hope I can... but doing a LO on the weekends is kinda tough. Perhaps I can do a Layout every weekday... and 2 on 2 days to make up for the weekends!! LOL!
Here is a LO I did today using the monthly kit from Leaving memories. I'll admit... the colors are VERY different for me... but I'm happy with my page!
I'm dying to dig into my SEI Petals & Pasleys goodies from Leaving Memories June sponsor!! It's so beautiful! I promised myself I'd get some of the kit LO's done first... and i have 2/3 done... now I can dig in!! :)
Just got back from taking Jasmine to soccer. She did so good tonight! I was so proud! :)
Posted by Tina McDonald at 8:15 PM
1 comment:
Thank you so much for taking the time to leave a comment! I deeply appreciate each and every one of you!
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What is Stewardship?
Stewardship is the giving back of the gifts the God has given to you. These include your TIME, your TALENTS, and your TREASURE.
For many of us the most difficult step to take is to generously share our Treasure. The reality of Cross+Road is, while we are one of the most successful Lutheran churches in the Synod, we remain what I like to call a "Paycheck to Paycheck" church. Much like a young family we have overhead, mainly the mortgage on our buildings, that many older churches don't have.
Some important facts about Stewardship at Cross+Road include:
If you'd like more information or would like to get involved please email us at firstname.lastname@example.com.
John Waidner
Kelly Lotze Stewardship Team Leader
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