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Reporting from New Orleans
Numbers must lie, because New Orleans Hornets star Chris Paul nearly had his second triple-double of the series Thursday night.
What game was the final stat sheet watching?
Paul finished with 10 points, eight rebounds and 11 assists in his team's 98-80, season-ending Game 6 loss to the Lakers at New Orleans Arena.
His triple-double in Game 4 was considered one of the great feats in NBA history. He became the only player other than Oscar Robertson with at least 25 points, 15 assists and 10 rebounds in a playoff game.
Paul's near-triple on Thursday was more comparable to Oscar Mayer.
Paul had been terrifyingly terrific through five games, the player single-handedly responsible for the Hornets' extending the Lakers beyond an expected four-game sweep.


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Wow - its May. Where the heck did that come from? It's feeling more and more like summer and I kind of like it. Along that summery theme comes today's nails... but first, if you haven't already entered my giveaway to win goodies from Essie, Sleek and A-Derma click HERE to enter now!
Today's nail look is one you've probably seen a million times before by now. The hype around the Barry M Gelly Hi Shine nail paints has been pretty unavoidable. I fell in love with this shade as soon as I saw it peeping out from behind some other colours in my local Boots. I had to have it! It's just the right shade to be bright enough for Spring but not too over the top to be unsuitable for work.
I've found all the Gelly Hi Shines I've tried so far to be really very decent quality for the price, which is £3.99. The consistency is thick, although I prefer to thin it out and apply 3 thinner coats to achieve better overall consistency. It lasts well for a drugstore brand, and the colour range is impressive. It's not the absolute best quality of every nail varnish I've ever tried, but it's worth having at least a couple in your collection. I think this shade, Green Berry, is ideal for porcelain gals like me but would also look super snazzy on someone with a nice glowy tan, a real all-rounder shade.
You can buy Barry M Gelly Hi Shine nail paints for £3.99 online HERE or from Boots in store or online (HERE).
What do you think of the Gelly Hi Shine polishes? Are you tempted to try Green Berry?
Follow via: Bloglovin Bloggers Twitter Facebook She Said Beauty

subset: commoncrawl


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This week's featured property comes from DJ Alexander Lettings. This three bedroom, luxury apartment is available now!
Situated on a prestigious street in an affluent area and offering pleasant views over the Brurgess Golf Club, this beautifully appointed and generously proportioned apartment offers an exceptional standard of accommodation. The internal common areas are immaculately maintained and the grounds are beautifully landscaped.
The property benefits from secure gated entry, private garage parking and three balconies.
The apartment itself is set over two levels, with three double bedrooms, the third of which can be found on the lower level. There is an extremely spacious living area with dining space, utility room and fully equipped kitchen. There are three bathrooms and three large balconies, all offering attractive, open views.
The property has an integrated sound system wired to all the rooms and many other impressive luxury features


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Danilo Gossain is a twice nominated LatinGrammy producer, arranger, and percussionist. Passionate about music from a young age Danilo began his studies in Bogota, Colombia before traveling t... Read more
"Melona" is a beautiful and banging album that was conceived, crafted and performed in the spirit and essence of rap, all bathed in chilled and trippy soundscapes by re-branded artist... Read more
Featured many times on BBC Introducing and as well as on BBC Radio 6, TheKunig's music has also been played regularly on radio stations across the globe. TheKunig skillfully combines j... Read more
Tony Vegas: "Midnight Hideaway" ft. Destiny – perfectly balanced tempo, contrast and instrumentation
Tony Vegas is an Australian DJ producer, currently based in Budapest has had three successive TOP 10 songs on the Beatport chill out chart – "Daydreamer", "Clock Tripper" and "Crystal... Read more
Tony Vegas & A. Portsmouth ft. Natalie – "Crystal Waves" resonates with a plethora of deeply rooted emotions!
Tony Vegas is an Australian DJ producer, currently based in Budapest. His style is focused on nu disco, indie house and chill out. He has had two TOP 10 songs on the Beatport Chill out Chart... Read more
"Moonray" is the third free release from "The Love Theme" as they prepare their sophomore Album set for release later in 2016. I believe strongly in music that makes an atmosphere, it is one... Read more
Jeff Woodall was born in London and raised in Hertfordshire, UK. Following high grades in a school 'Tone' test at his secondary school, music lessons were recommended. So, of all the instru... Read more
The Love Theme is the brainchild of producer Dominic Owen on his Smokersblend record label. "U Made Me Love You" is the second of several free single releases as the band prepare... Read more
InternalEye has a style that is separated from other ambient artists. He does not become monotone half-way through his work; it's a much more moving experience. Though my tastes tend... Read more
Late bloomer Léon Permentier aka LeVirya has just begun to grow his love for electronic music. Being a true music lover for most of his life he never got much further than playing tunes on h... Read more
Atlas Screams is an electronica artist from Baton Rouge, Louisiana. He produces new songs weekly and his entire discography is available for free at www.soundcloud.com/atlasscreams. Two week... Read more
Andrew Jhavery aka Chung Nation is an electronic music producer from Sydney Australia, who also has a penchant for using real instruments in his tracks, "I really want to use more real instr... Read more
Worldwide Groove Corporation, Nashville's electronic music power duo, made up of Kurt Goebel and Ellen Tift committed to putting out one new music release a month for at least a year. ... Read more
Founded in 2010, Squaresyntax (aka Mike Wiley) started as a side project of Lunapollo and Common Man Down. Since then, Squaresyntax has evolved over many albums and single releases, includin... Read more
"Into Existence" Finds SEMTEX Side-Stepping Thoughtless Attitude and Digging Deep into the Psychological Being
SemTex Started his love for music growing up listening to bands such as Greenday, blink 182, Nirvana, Queen and Metallica. After years of moshing and headbanging he settled down and broadene... Read more
BURUDU is Nakul Sharma and Sahil Bhatia, who got together during early-2013 to create a sound that signifies singularity. Bringing together their influences from deep house and chill out mus... Read more
SUANDA, by the Russian duo Offshore Wind & Roman Messer featuring Ange on vocals, represents the first release for the new Suanda Music record label. The single comes in 2 original versi... Read more


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The Library and Information Technology Association (LITA) is piloting a new YouTube presence, and the Top Technology Trends Committee is excited to be a part of this effort. The Committee is working on a pilot project to share short, informal videos from past and present Top Technology Trends panelists. These videos will serve as current sound-bytes on technology trends of interest to the library community. It's hoped that the number of videos will grow over time, and play a role in fostering a sense of community during the time between ALA's Annual and Midwinter meetings. The Committee would like to thank Jason Griffey for producing the first video, available now at LITA LibraryInfoTech's Channel: http://youtu.be/OVdZlvIcMok
(American Libraries Direct, June 15, 2011)
Thursday, June 16, 2011
LITA and Top Tech Trends for 2011
Posted by Wisconsin Valley Library Service at 10:21 AM
1 comment:
- AnonymousOctober 8, 2011 at 8:02 AM
Nice information.....thanks.ReplyDelete
Subscribe to: Post Comments (Atom)


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Here are my top 20 favourite books (at least for now!). I had a hard time choosing because my books are kind of like my kids. I don't like playing favourites. However, I'd rate all these as transformational. And what I really love about them is that they are a combination of logic and rationale with intuition, which is my kinda my vibe.
Also, most of them discuss how mindfulness, meditation, yoga and key spiritual principles (acceptance, gratitude, presence, compassion) really work - which is something humans have known for centuries - but that science is just catching up with.
Here they are:
Daring Greatly: How the Courage to Be Vulnerable Transforms the Way We Live, Love, Parent, and Lead, Brene Brown
The Power of Vulnerability: Teachings on Authenticity, Connection and Courage, Brene Brown
The Body Keeps the Score, Bessel van der Kolk, PhD
Getting the Love You Want, Harville Hendrix, PhD
Letting Go: The Pathway of Surrender, David R Hawkins, M.D. PhD
Mind Over Medicine, Scientific Proof That You Can Heal Yourself, Lissa Rankin, MD
Getting Unstuck, Pema Chodron
When Things Fall Apart, Pema Chodron (I love her audiobooks because she has such a soothing voice)
The Art of Happiness, The Dalai Lama XIV and Howard Cutler, MD
The Seat of the Soul, Gary Zukav
The Power of Now, Eckhart Tolle
A New Earth, Eckhart Tolle
The Road Less Travelled, M Scott Peck, MD
The Power of Intention, Wayne Dyer, PhD
Sacred Contracts, Caroline Myss, PhD
The Anatomy of the Spirit, Caroline Myss, PhD
Outrageous Openness: Letting the Divine take the Lead, Tosha Silver
A Hidden Wholeness: The Journey Toward an Undivided Life, Parker Palmer
The Highly Sensitive Person, Elaine D Aron, PhD
The Empath's Survival Guide, Judith Orloff, MD
Photo Credit: Photo by Jamie Taylor on Unsplash


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Friday evening as I was setting my alarm for a 7:30 A.M. appointment the following day, Saturday, I received a call. Curious. What could have inspired this person to call me up hmmm?
After the usual greeting, the first line goes: "Belinda, do you speak Ilonggo?"
That finally hit me. Why is it that after so many years in the city, I have not learned to speak Ilonggo? Hmmm. Most of my colleagues at work were Ilonggos and almost everyone else can speak Ilonggo but I can only understand a handful of words. Tsk…tsk. My loss.
So this weekend, I will start my Ilonggo crash course. I have got to speak the language man! It's a must.
Ilonggo (Hiligaynon), here I come.


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Source: National Bureau of Economic Research
Release: NBER Macrohistory Database
Series Is Presented Here As Two Varibales--(1)--Original Data, 1890-1951 (2)--Original Data, 1947-1956. These Data Are On A 1947-1949 Base, And Are Based On Prices For"Special Metals And Metal Products," Consisting Of The"Total Metals And Metal Products" Group, Plus "Agricultural Machinery And Equipment" And "Motor Vehicles." They Are Comparable To The Former Index (1926=100) For "Metals And Metal Products" (Bls Undated Summary Table Quoted Above, Footnote Ii). Source: Bls "Wholesale Price Indexes For Special Groupings Of Machinery And Steel Products (1947-49=100), " Undated Release Issued By Bls In May, 1952, For The Period 01/1947-02/1952; Monthly Wholesale Price Releases Thereafter.
This NBER data series m04066b appears on the NBER website in Chapter 4 at http://www.nber.org/databases/macrohistory/contents/chapter04.html.
NBER Indicator: m04066b
National Bureau of Economic Research, Index of Wholesale Prices of Metals and Metal Products for United States [M0466BUSM349NNBR], retrieved from FRED, Federal Reserve Bank of St. Louis; https://fred.stlouisfed.org/series/M0466BUSM349NNBR, February 21, 2019.


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The onion, also known as the bulb onion or common onion, is used as a vegetable and is the most widely cultivated species of the genus Allium
An essential kitchen vegetable, onions are arguably the world's most widely used ingredient. They vary in shape and colour from flattish brown to round pale bulbs but share a common structure, with a papery outer skin and protecting inner layers of pale, crisp flesh. Yellow onions are hot and pungent enough to make your eyes water; Spanish onions are the largest, with brown skin and a mild, sweet flavour; brown onions are a smaller variety of yellow onion with an even more pungent flavour, making them a good all-rounder. Source: http://www.bbc.co.uk/food/onion


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So remember the beautiful mullet? Well, it's gone. That's right, Bud got a haircut! This haircut was prompted by a couple things. 1. About 984,756 people commented on Bud's mullet… a lot of them with genuine concern and some with genuine jealousy (we WERE in North Carolina after all) and 2. He was called a little girl at the airport.
Sam did it and it was very drama-free (minus the part where I cried because he looked older and I proceeded to put his curls in a zip lock bag). So is it weird to anyone else that we keep our children's remnants of their first hair cut? I feel like if someone without kids were to come in our house and search through baby books, they'd think we were serial killers/creepers. A lot of teeth, hair remnants, and photos of kids sleeping. Super.
So Bud went from this :
To this:
And we've all heard about my nursery battle with Bud. Well, this Sunday was the first Sunday in a REALLY long time that I can remember not being called back during the service. Yes, he still screams his head off when we drop him off and yes, when Sam went to go get him, my son was pantless (please don't get me started on this one) BUT I didn't get this message which is a Christmas miracle.
It was a nice weekend, COLD, but nice. How was yalls!?


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No end in sight to deadly Zimbabwe typhoid
From MARCUS MUSHONGA in Harare, Zimbabwe
HARARE, (CAJ News) – A RAGING typhoid outbreak is stretching Zimbabwe's collapsing health sector to the limit and left the country on the verge of its worst disease catastrophe in a decade.
Spreading with no end in sight, it has evoked memories of a cholera outbreak that claimed 4 000 lives for months in 2008.
The capital Harare continues reeling under conditions suitable for the spread of typhoid, which like cholera is waterborne.
With two deaths reported from 132 cases this week, the situation remains dire.
Burst sewerages, unsafe water and poor sanitation, which are conditions typhoid has thrived under, are commonplace in the southern African country's cash-strapped cities.
The Zimbabwe Association of Doctors for Human Rights said it was appalled by the failure by the City of Harare and the Government to stem the spread.
The administrations have failed to prioritise safe, clean water and the environment as key tenets of strong primary healthcare.
"ZADHR further contends that the typhoid outbreak must allow residents to take stock of their local authorities and also the negligence of supervision by central government."
The organisation encouraged residents to exercise good personal hygiene and the medical profession to help find solutions.
Typhoid is the latest test to a health sector suffering from Zimbabwe's economic and political crisis.
Doctors have joined millions fleeing the country while those remaining are usually on strike.
The broke government of President Robert Mugabe has struggled to procure drugs and medicines, forcing major hospitals to suspend surgeries.
Neighbouring South Africa recently said it was on high alert following the outbreak in Zimbabwe.
Short URL: http://cajnewsafrica.com/?p=17392


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If treating obesity was as easy as modifying one's diet and exercising more regularly, we wouldn't have an obesity epidemic in America today. Because the causes of obesity are so complex, achieving profound and lasting weight loss often requires a multifaceted treatment approach. Today, we know that some bodies are hard-wired to regain any weight they have lost, regardless of whether the individual in question weighs 140 pounds or 400 pounds. The more pounds we shed, the more our bodies increase our hunger response, driving us to eat more and restore our prior weight. As a result, the vast majority of diets fail over the long term.
In decades past, bariatric surgery was the only way to short-circuit this cycle. By reducing the capacity of the stomach, bariatric surgery helped obese patients limit their food intake and avoid regaining weight. Like all surgeries, however, bariatric surgery is not without its risks. Hernias, stomach perforations, bowel obstructions, and other issues can all arise from having bariatric surgery. What's more is that these problems can be difficult to correct and require further surgery. That's why so many people are opting to try Obalon instead: This nonsurgical weight loss solution offers many of the same benefits as bariatric surgery, but without the risks.
What is Obalon?
Obalon is a system of three temporary gastric balloons that are easy to insert and remove. Obalon balloons are inserted into the stomach via the esophagus while deflated, then inflated once they are inside the stomach. After the balloons are inflated, they will take up room in the stomach to help patients feel full after eating. This helps them lose weight at a faster pace; patients who have Obalon have been shown to lose weight twice as fast as patients who rely on diet and exercise alone. Better still, Obalon is associated with greatly improved long term weight loss outcomes:
Patients have been shown to retain, on average, 89% of their weight loss after one year. (Note that these patients also maintained a healthy diet and exercised during this period.)
What to Expect with Obalon
Obalon insertion takes just 10 minutes to complete, making this the most convenient medical weight loss solution currently available. No incisions are made during the placement or removal of Obalon balloons, so patients will not experience significant post-surgical discomfort. Moreover, they are usually able to return to their normal activities within a few days. During an Obalon appointment, the patient simply swallows a capsule that contains a weight loss balloon, then a physician inflates the balloon. The patient does not have to be sedated during this process.
As mentioned above, Obalon balloons are intended to remain in place for a limited time period. After six months, they must be removed. By this time, however, most patients find that they have learned new eating habits: They're used to preparing and eating smaller portions of food and their brained have been "trained" to associated feelings of satiety with lighter meals. This makes it easier for Obalon patients to stick to their long-term weight reduction strategy.
Obalon has been approved by the FDA and is generally very safe; less than 1% of patients experience serious side-effects. You may experience some mild abdominal pain and nausea while your body adjusts to the presence of the Obalon balloons, but these symptoms usually resolve on their own within two weeks.
Who Makes a Good Obalon Candidate?
Obalon has only been approved for use in obese patients, i.e. those with a body mass index (BMI) of 30 to 40 kg/m2 or greater. You must be in good overall health in order to have Obalon and you must be willing to adhere to a healthy diet and exercise program. Remember that no medical weight loss solution is intended to act alone—only by changing your lifestyle can you both achieve lasting victory against obesity and ensure that you maintain optimal health.
Ready to Win the Fight Against Obesity? Book a Consultation
If you're obese, losing weight is one of the best things you can do to protect your physical and emotional health. The experts at Ritacca Laser Center are here to help you get there. If you're ready to kick start your weight loss journey, contact our Vernon Hills cosmetic surgery office today. We provide surgical and nonsurgical health and aesthetic wellness solutions to patients throughout Illinois.


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Waterproof Membrane For Bathrooms
Help your house be being the easiest site giving productive variations prefer all shots around Waterproof Membrane For Bathrooms image collection present to you. You can observe very many varieties opportunities Waterproof Membrane For Bathrooms image collection gives you that could be burned. Comforting truly feel could be noticed divorce lawyers atlanta spot of your home inside Waterproof Membrane For Bathrooms graphic collection, this could make this property owners could be very handy. It is also possible to fill out an application some ideas that one could acquire because of Waterproof Membrane For Bathrooms snapshot collection to your dwelling. Your personal unattractive residence shall be shortly changed into an awfully comfortable location to put out this difficulty associated with get the job done. Such form of Waterproof Membrane For Bathrooms photograph stock will allow you build a house that can fit your entire pursuits, perhaps you will be able to end your career in the house comfortably. There are many reasons why you should choose Waterproof Membrane For Bathrooms photo stock being a a blueprint. Considered one of that is because Waterproof Membrane For Bathrooms picture gallery solely provide world class in addition to endless layouts.
As adjective
impervious to water
rendered impervious to water by some special process, as coating or treating with rubber:a waterproof hat
As noun
Chiefly British
a raincoat or other outer coat impervious to water
any of several coated or rubberized fabrics that are impervious to water
As verb (used with object)
to make waterproof
As noun
a thin, pliable sheet or layer of animal or vegetable tissue, serving to line an organ, connect parts, etc
Cell Biology
the thin, limiting covering of a cell or cell part
As preposition
with the object or purpose of:to run for exercise
intended to belong to, or be used in connection with: equipment for the army;a closet for dishes
suiting the purposes or needs of:medicine for the aged
in order to obtain, gain, or acquire: a suit for alimony;to work for wages
(used to express a wish, as of something to be experienced or obtained):O, for a cold drink!
sensitive or responsive to:an eye for beauty
desirous of: a longing for something;a taste for fancy clothes
in consideration or payment of; in return for: three for a dollar;to be thanked for one's efforts
appropriate or adapted to: a subject for speculation;clothes for winter
with regard or respect to: pressed for time;too warm for April
during the continuance of:for a long time
in favor of; on the side of:to be for honest government
in place of; instead of:a substitute for butter
in the interest of; on behalf of:to act for a client
in exchange for; as an offset to: blow for blow;money for goods
in punishment of:payment for the crime
in honor of:to give a dinner for a person
with the purpose of reaching:to start for London
contributive to:for the advantage of everybody
in order to save:to flee for one's life
in order to become:to train recruits for soldiers
in assignment or attribution to: an appointment for the afternoon;That's for you to decide
such as to allow of or to require:too many for separate mention
such as results in:his reason for going
as affecting the interests or circumstances of:bad for one's health
in proportion or with reference to:He is tall for his age
in the character of; as being:to know a thing for a fact
by reason of; because of: to shout for joy;a city famed for its beauty
in spite of:He's a decent guy for all that
to the extent or amount of:to walk for a mile
(used to introduce a subject in an infinitive phrase):It's time for me to go
(used to indicate the number of successes out of a specified number of attempts):The batter was for in the game
As conjunction
seeing that; since
As Idioms
for it, British
in (def )
As noun
a room equipped for taking a bath or shower
toilet (def )
As Idioms
go to / use the bathroom, to use the toilet; urinate or defecate
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Related Projects
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In recent years the building industry has focused on meeting the needs of millennial renters, homebuyers and corporate tenants as well as older generations with changing housing needs. Wood infill development in both city centers and the suburbs can offer the opportunity to create relatively affordable new housing in dense, walkable environments.
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La Peña's "Song Of Unity": The Mural and the Silkscreen
The motif of the mural that dresses the façade of La Peña Cultural Center in Berkeley, California clearly represents the unity of the Americas with the Wings of the Condor spanning left protecting a representation of peoples of South America, and the Wings of the Eagle to the right stretching across North Americans accompanied by a centrally placed beautiful long tailed Quetzal Bird for Central Americans, which was painted into the original composition to embrace the peoples and customs of that region. As a cultural and social activist center shared by Latin Americans and North Americans, La Peña happily celebrates an unexpected longevity of 40 years serving the community, now turning the reigns of leadership to a new generation. The original mural created in 1975 greeted the community with pride, hope, good cheer, and promise – when it was scheduled for removal (having worn with the years) a protest was mounted and resulted in fund raising for renewal of the mural and its theme but with some changes.
Responding to the public outcry to retain the old mural, which was beyond repair according to city ordinances for fire and safety, Radames Rivera directed the "Song of Unity" silkscreen project to create an edition of prints that retain the original mural. He collaborated with the Taller of Coco Gonthier of the Dominican Republic – silkscreen workshop - and artist and CODAP Director (Colegio Dominicano de Artistas Plasticas), Clinton Lopez to author the artwork to create a 32 color silkscreen in a faithful rendition so that the original image of "The Song Of Unity" would be preserved.
The silkscreen image is 35" x 11" printed on 200 gram Fabriano paper sized at 14" x 39 ½ " allowing a border for framing requirements. The thirty-two-color fine art printing took almost a year to complete as each color requires a separate stencil to be designed and cut and each color is printed separately. A screen is built by wood framing methods to the size paper and a screen is stretched over it which may be silk, nylon mesh or even, today, a very fine metal mesh (silk fabric was used before other screen materials were developed to allow the inks to be pushed through with a rubber squeegee). The stencils block out areas not to be printed and only the area for the color chosen is exposed. The edition is printed in one color, and when dry then the next stencil and color is printed and the process is repeated as many times as the number of colors chosen to complete the image. Simple silkscreen prints can be made with a few, or even one color, while complex silkscreen prints have many colors used in the printing.
This Silkscreen is a collector's piece made with skill and the finest art materials to honor La Peña Cultural Center, its dedication to social justice and to all of peoples of Latin America and North America working together to make a better world.
"Song of unity" PCC1
32 color silkscreen printed on 200 gram Fabriano paper$75 each S&H included
image: 35" x 11"
paper size:14" x 39½"


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PINK – FEB issue
Christmas has long been relegated to a distant memory and we're now trying to survive the chilly winter months ahead. Hopefully we are all feeling revived and resolute and determined to keep up any new year resolutions we've made. One of the most current issues is that of living in a less wasteful and more mindful way. To help you out PINK has rounded up ten ways to achieve this but before you start we suggest you conduct a waste audit to see what you're currently throwing away and what you can reduce on. Spend a week being aware of what you throw away and then replace at least one of the disposable items with a reusable option such as shopping bags and shaving razors.
To help you out PINK has rounded up ten ways to achieve a less wasteful life:
1. Give your wardrobe an instant uplift with a clothes swap which is a brilliant way to reuse your clothes rather than getting rid of them.
2. If you don't find a home for those unwanted clothes drop them off at a charity shop and help a good cause in the process.
3. And for those clothes which are beyond repair, cut them neatly and add them to your cleaning things. Wash them regularly and reduce the amount of paper napkins used in an instant.
4. Buy reusable bottles for beauty products and refill them – this will immediately reduce the amount of plastic you use.
5. Buy microfibre cloths for your face and reduce the amount of cotton wool or tissue paper you use.
6. Think twice before you buy another beauty product – ask yourself do you really need it or is it another impulse buy? Those extra few minutes can make all the difference, even saving you money in the process.
7. If you think that your body moisturizer is finished think again. Cut across your beauty products and see what a lot gets left behind or thrown away simply because it doesn't come out immediately.
8. By spring cleaning regularly you'll be reminded of just how much stuff you already have which is more likely to curb the next shopping urge you get thereby reducing the amount of unnecessary items you buy.
9. Repair before you throw away items. Find an excellent cobbler who will repair handbags, shoes and even belts and give them a new lease of life.
10. Take responsibility for your shopping sprees and refuse excessive shopping bags, shoe boxes and plastic packaging and ask sales people not to wrap your purchases. This will save on extensive use of plastic and might even help to spread the word
For more tips on how to reduce and manage your waste properly please visit http://www.dontwastewaste.gov.mt/4


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Update: The Chicago Bears have matched the Packers offer sheet. It is a four-year deal worth $56 million. $18 million is guaranteed.
The #Bears are matching the #Packers' offer sheet for CB Kyle Fuller, sources said. Fuller stays.
It's a 4-year deal worth $56M. The key number is $18M guaranteed. Fuller already had $13M guaranteed from the translation tag. For $5M more guaranteed, they get him long-term🔒💰
— Ian Rapoport (@RapSheet) March 16, 2018
One of the NFL's biggest rivalries has left the field and now enters the boardroom. The Green Bay Packers have signed cornerback Kyle Fuller to an offer sheet.
Earlier this off-season, the Chicago Bears placed the transition tag on Fuller, meaning that they will have five days to match the offer. The transition tag would have seen Fuller get a one-year guaranteed $12.971 million contract in 2018. However, his contract will now be based on the terms of the offer sheet. Financial terms of this offer sheet to follow.
#Packers have signed #Bears CB Kyle Fuller to an offer sheet. Chicago placed transition tag ($12.9067 million on Fuller). So things will get interesting in the NFC North as the rivals compete for the former first-round draft pick.
— Brad Biggs (@BradBiggs) March 16, 2018
Kyle Fuller Signs Offer Sheet with the Green Bay Packers
Fuller was a top draft prospect coming out of Virginia Tech in 2014. He earned a host of awards during his college career, including a Second-Team All-American selection in 2013.
Mike Mayock described him as the "most NFL-ready cornerback" and compared him to Brandon Flowers in advance of the 2014 NFL Draft. He was taken 14th overall by the Bears after four seasons with the Hokies, becoming only the third cornerback taken in the first round in team history.
In his first season with Chicago, the rookie burst onto the scene following an injury to Charles Tillman. The first-round pick earned his due, racking up 64 total tackles, ten passes defended, four interceptions, and three forced fumbles. The team awarded him the Brian Piccolo Award after his rookie season for his loyalty, dedication, and teamwork. His numbers dipped slightly in 2015, recording 55 total tackles, nine passes defended, and two interceptions. Then, tragedy struck.
Fuller underwent an arthroscopic knee surgery in mid-August 2016 and struggled to recover from the injury. The Bears placed him on injured reserve, and the former first-round pick failed to see a single snap during the 2016 season. As a result, the Bears declined to pick up the fifth-year option that would have kept Fuller in Chicago for the 2018 season. This was a decision they soon came to regret. Fuller bounced back in 2017 with 69 tackles, 22 passes defended, and two interceptions. His 22 deflections led the league in 2017. Several sources have floated comparisons to Pro Bowler Casey Hayward. In late February, NFL.com named Fuller as the top cornerback hitting free agency this off-season.
The knee surgery that kept him out of the 2016 season marks the only time an injury has kept Fuller from the field for a full season. A sports-hernia forced him to miss the final four games of the Hokies 2013 campaign.


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How We're Different
At Lead Tech, we deliver high quality financial advisor leads and IFA lead generation services – our strategies are based around your individual needs.
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Our campaigns are at the cutting-edge of online marketing, and fully integrated across a number of channels.
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Eno, North Carolina seems like the perfect place to hide. Working at a local café is light years from Maddie's Manhattan existence and for the first time in a while, she's finding her family. There's Grandma, the café owner; Samantha, the hairstylist next door with plans to make Maddie's life unsuck and Noie, the three year old girl who's stolen Maddie's heart.
And then there's Gabriel Mendez, Noie's single dad. He's intrigued Maddie since the first time she met him, and while he has his own secrets, he wants more from her than just friendship. But the past never stays past, and all too soon, Maddie realizes she can't hide from hers. If she can't put the pieces of her shattered life together this time, she'll have no hope for a future.
A future she desperately wants.
First line:
It had been seven hours and fourteen minutes since I had completely and utterly lost my mind.----------
ARC from Author --THANKS----------
4 heart breaths out of 5----------
I fell in love with this heart-breaking novel. The story is real and amazing. Maddie's pain was gut-wrenching. Gabe has a good background. Maddie's history is painful. I hurt for her and yet loved delving into her past. Gabe's past is similarly painful, but not as much as Gabe's. But Noie is the one who stole my heart. I have two younger siblings around the age of three and I love little kids. I could just picture her running around everywhere. She is the character that came to life the most. And, like Maddie, I fell in love with her.
The only thing that prevented a five star rating was that the reincarnation thing was kinda strange. But it did fit in with the whole Indian heritage thing.
Heart Breaths is a very real, heart-breaking, yet beautiful and hopeful novel. I recommend it for everybody.


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Penn State Hiring Eight Full-Time Staffers To Monitor Greek Life
Penn State released new details on the first day of classes about the university's roll out plan for new Greek life sanctions, including expanding Student Affairs with 14 new full-time staff members — eight of which are dedicated to monitoring organizations via random checks for compliance.
As announced when the Board of Trustees approved the plan in June, responsibility for disciplining the Greek member organizations will now be in the hands of the university — starting today.
"We have quickly instituted an expanded series of strategies that defines a new relationship between the University and its Greek-letter organizations," President Eric Barron said in a press release. "And this is just the beginning. We plan to continue to roll out measures and adjust as needed, with the Greek-Life Response Team and its advisory group evaluating each measure and recommending adaptations as necessary to promote and produce responsible behavior."
Eight of the new staffers will be "dedicated to monitoring Greek-letter organizations via random checks to monitor compliance with university policies." The university expects Greek organizations to allow these spot-checkers to enter any and all common areas in chapter houses. Anyone violating regulations will be referred to the Office of Student Conduct.
The social moratorium announced in the spring continues until all chapters complete required educational and risk-management programs. The moratorium will be lifted no earlier than November 1.
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About the Author
Trustees Committee Approves Sandy Barbour Contract Through 2023
Sandy Barbour will make an average of $1,269,000 per year as part of the new deal, which runs through August 2023.
Your THON 2019 Master Playlist
With more than 500 songs and a run-time of more than 30 hours, this playlist will make it seem like THON never ended.
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Name: Babettes feast 1987
File size: 718mb
Language: English
Rating: 5/10
Babette's Feast is a Danish drama film directed by Gabriel Axel. The film's screenplay was written by Axel based on the story by Isak Dinesen (Karen. 23 Jan The Danish/French Babette's Feast is based on a story by Isak Dinesen, also the source of the very different Out of Africa (). Stephane. At once a rousing paean to artistic creation, a delicate evocation of divine grace, and the ultimate film about food, the Oscar-winning Babette's Feast is a deeply.
Even in the climactic feast, there is no collapse into epicurean dissolution or "food pornography." Elevation, not mere gratification, is the goal of Babette's Feast. 3 Apr Then in , Gabriel Axel's film of the story 'Babette's Feast', a sensuous celebration of the pleasures of good food and drink, won that year's. 8 Apr War refugee Babette works for 2 sisters & their ascetic sect. When she cooks a feast they reluctantly eat but soon the grace of the meal.
He is the one who, unknowingly, identifies Babette as the famous chef from Paris' "Cafe Anglais," and provides the catalyst for the enjoyment of the feast. Babette's Feast deservedly won the Academy Award for Best Foreign Language Film. This lovely movie is impeccably simple, yet its slender narrative. MPAA Ratings: G, Premiere Info: Release Date: , Production Date: Color/ B&W: Distributions Co: New Yorker Films/Orion Classics. Sound: Production Co. 27 Mar Stephane Audran, Star of 'Babette's Feast,' Dies at AM PDT Orion Classics/Photofest. Stephane Audran in 'Babette's Feast' (). 26 Nov The movie of the week for November 20 through 26 is Babette's Feast (), which is available to digitally rent on Amazon and iTunes.
DOWNTOWN INDEPENDENT PRESENTS: "BABETTE'S FEAST" (). May 30, PM - AM. Los Angeles | Downtown Independent · $ 22 Jan In a remote 19th-century Danish village, two sisters lead a rigid life centered around their father, the local minister, and their church. Both had. 11 Nov Babette's Feast (; Cert. U; Comedy, Drama, Music) is the Rusthall Community Cinema film this Saturday. Doors open at film starts. 12 Nov BABETTE'S FEAST (). Type Feature. Approx. Running minutes Release dates 14/11/, 01/08/ BBFCInsight Contains no.
Shop Babette's Feast [Blu-ray] []. Everyday low prices and free delivery on eligible orders. Rent Babette's Feast () and other Movies & TV Shows on Blu-ray & DVD. 1- month free trial! Fast, free delivery. No late fees. 7 Nov A moment of sacrifice and generosity in this classic. Find trailers, reviews, synopsis, awards and cast information for Babette's Feast ( ) - Gabriel Axel on AllMovie - The Danish/French Babette's Feast is based.


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7 Helpful Apps for Parents of Children with Autism
Technology, and tablets, in particular, have made new approaches possible to teaching students with autism spectrum disorders. They have provided tech-minded parents and teachers with a number of very specific tools, and children – with the possibility to control a small part of their environment and, above all, the opportunity to communicate. Here are some helpful apps aimed to develop necessary skills in autistic children and provide advice and information for their parents.
Available: iOS, Android, Web
Cognoa is an evaluation tool that helps to identify autism in children, assess and track their development, as they reach the important milestones. It is possible to receive a detailed feedback on your child's progress, based on short videos of his or her natural behavior at home.
The results can be shared with teachers and pediatricians. You can also join the community of aware and active parents, that help their children with different issues. In addition, the service provides expert-recommended activities, which can help autistic children to improve their fine motor and sensory skills, socialization, and more.
The Connections
Available: iOS, Android
Lamarque Polvado, the founder of CareStarter, who developed the app, felt helpless when his daughter was diagnosed with autism. He knew nothing about the disorder. Unfortunately, the doctor was not very helpful, leaving Polvado with a "sheet of paper full of grim statistics".
Therefore, his main goal was creating a referral portal to help parents and caregivers in overcoming fears and anxiety that usually accompany a diagnosis of a chronic condition. The app provides all necessary information, diagnosis-specific content and aims to build the community of people with similar concerns, who help each other.
Autism Track
Available: iOS
The app was created for parents and caregivers of autistic children in order to collect different data specific to this condition, track progress, medication, behaviors, and symptoms (e.g. eye contact, echolalia, aggression, etc.), and based on this determine what is working and what is not.
The clean and intuitive interface (with sliders and checkboxes) allows keeping a record of every occurrence day by day and it only takes minutes. What is more important, it allows adding your own symptoms and intervention to the standard data set. Different caregivers can access a profile of the child, as well as different profiles can be created within one account (to track more than one autistic child.)
Available: iOS, Android
Nearly half of the children diagnosed with ASD tend to wander off, mainly due to the difficulties they experience with expressing themselves and making contact, so they cannot ask other people for help and provide the information that is essential for their identification. This monitoring app has a feature of GPS-tracking, so you can always see where your child is. It alerts you if he or she leaves the safe zones that you have defined, provides a record of the routes and a current location of the child.
First-Then Visual Schedule
Available: iOS, Android
The app was created as communicative aid, to help caregivers in providing a structured environment for children with ASD and other developmental issues. It empowers parents and teachers to give positive behavioral support via step-by-step "visual schedules".
Though often having troubles with reading comprehension, autistic children are usually very good with images, so visual schedules are going to be of great help. All kinds of schedules can be easily created and customized for daily routines, as well as for some specific tasks with the use of your own photos and your voice recordings. You can choose among three different formats (full screen, first-then screen, and list screen) the one, which meets the needs of your child or ward.
Learn with Rufus: Feelings and Emotions
Available: iOS, Android
Not every child with Autism has communicative issues, however, they are very common. Children diagnosed with autism often struggle to identify emotions of people around them and respond accordingly, hence the difficulties with communication. The app aims to help children with learning facial expressions, essential for social interaction.
It uses friendly animated character, Rufus Robot, and a selection of images to introduce the emotion words and provides a number of games and activities for securing them in the memory, and simply for relaxing during the break. The app is highly customizable to meet the needs of children of various ages, abilities, and needs. It also keeps track of the progress and stats.
Toca Boca
Available: iOS, Android
Toca Boca is not just a single app, but a series of apps aimed to teach young children social interaction and some practical skills. A hospital, a hair salon, a kitchen, a birthday party – there is a number of environments, situations, and types of interaction, with which a child can familiarize with a help of these games. This is great for social skills and imagination because of Toca Boca apps, apart from being beautifully drawn and user-friendly, allow kids to create their own stories. Moreover, these apps also teach math and basic money handling.
These apps can help parents with assessing the developmental progress of their children and ring the changes to learning routines making them entertaining and engaging. They will help kids with ASD master social and cognitive skills and feel more confident in otherwise confusing and hectic world. The important thing is to be consistent and ensure that the child uses the same apps (or even the same device) at home, at school, and in all other environments.
Jana Rooheart is a blogger and online safety expert. She is devoted to making the Internet safer for kids and to warning parents about all the possible hazards of online activities.


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Women's Protective Club
Women's Protective Club is a corporation registered in the state of California.
It is a domestic corporation, meaning it was formed, as well as registered, in California. Its articles of incorporation were filed on June 23, 1916.
Women's Protective Club's business registration is active, and the corporation is authorized to do business in California, as long as they meet any other legal requirements that may be subject to.
Women's Protective Club is a nonprofit mutual benefit.
Shirley Dutcher
Po Box 837
Upper Lake CA 95485
Registered Agent
Clara Summerfield
9909 Old Orchard Ln
Upper Lake CA 95485


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Archive for the 'Xander' Category
1st Egg Hunt
Yesterday we went to the Easter Egg Hunt at our church. Xander kinda of remembered doing egg hunts last year but I don't think he really remembered it all that well. He had a great time. They broke up into groups and did a craft, played games, heard a story about a sand dollar, and of course got to go on an egg hunt. The weather was cold and wet so the egg hunt this year was inside. It was a morning full of fun!
Build & Grow
Patrick and Xander over the past year have gone to a few of the Build & Grow events put on by Lowes. They went for the 1st time in a while a few weeks ago and had a great time. Xander is getting really good at hammering and putting things together. This time they made a Monster Truck together.
Martin Luther King Weekend in Brown County
We again went to the cabin on Martin Luther King Weekend. We had a great time. This year Brennan, Laura, and Kal-el were able to join us which made it all the more fun. We also had a mini birthday party for Patrick, Ariel, and I on Saturday night. Xander and Kal-el had tons of fun playing with each other for the weekend. It was a great family get away!
Florida Trip!
The marching band traveled to Florida in December to play at Disney World. We decided to all go as a family. Xander and I flew down early to spend some time with my parents and Patrick traveled with the band as a chaperon. Xander and I had a great week in Florida. Grandma and Grandpa Warwick took Xander and I to Bush Gardens for 2 days. It was so much fun! The park was not crowed at all and we never waited on line for anything. In fact there were times when Xander was the only kid on the ride. Xander also really enjoyed swimming in the pool and riding the golf cart while at Grandma and Grandpa's house.
Later in the week we went up to Disney World to meet up with Patrick, Ariel, the band, and Grandma and Grandpa McCoy. Xander and I spent 2 days at the Magic Kingdom and Xander had a great time. The 1st day there we spent some time with Grandma and Grandpa McCoy and Patrick and Ariel joined us the next day. It was so much fun seeing the band march right before the Light Parade at night. It was a great few days at the Magic Kingdom.
Here is the video of the band marching at the Magic Kingdom and then some of the parade that followed. Enjoy!
Brown County Cabin
The weekend after Thanksgiving we headed out to the cabin in Brown County with Patrick's family. It was a great weekend full of relaxation and it was also when we found out we were having a baby girl!
1st Day of School
Everyone is now back in school. Ariel started her Senior year of High School on August 22nd. It's so hard to believe that she is now a Senior. It's been fun this summer going on college visits with her and wondering where she might go next year. She is one busy girl right now with marching band and the fall drama. It's been a great start to the school year for her.
Xander's 1st day of preschool was on August, 28th. He is again in Mrs. Henderson's room and is loving going to preschool again. He picked up this year just where he left off last year. It's been really nice having the same teacher because he know's exactly what to do. He loves going to "work" everyday with his backpack.
Forever Family Day!
August 15, 2012 marked 1 year as a Family of 4! What a year it has been! To celebrate the day we got Xander a gift that he opened 1st thing in the morning. It was an airport and boy does he LOVE it! He spent the entire day playing with it. That night Patrick, Xander, and I went out of Chinese food to celebrate. We love you Xander and are so happy you are in our family now!
One year ago we were very busy getting ready for our trip to China to meet Xander. This week last year we got our final update and pictures of Xander. It was so exciting to see those pictures and we could not wait to actually meet him and get to hold him. Along with the pictures we learned he was 32.8 inches tall, weighed 22.5 pounds, and he was wearing a size 5 1/2 size shoe. Take a look at what our boy looked like a year ago.
A year later and Xander has grown a lot in so many ways! He is now 37 3/4 inches tall, weighs 28 lbs, and is wearing a size 9 shoe! He is so much stronger now than he was a year ago. Take a look at our boy today.
Corn Roast
This past weekend we went up to Houston Woods for the afternoon to join Aunt Ree at Corn Roast. Aunt Ree was camping for the weekend with her horse and pony along with several other members of the Horsemen's Club. Ariel loves the Corn Roast and has been going for years. This was Xander's first time going and his first time seeing the pony and horse. At first Xander was a little nervous about the pony but soon he just couldn't wait to ride. It was a really fun afternoon and evening of riding and hanging out.


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It was a super fantabulous and lucky day for me yesterday.
Got to play dress up as a mad scientist while attending a media event.
And guess what?
I won best photo in the search for the Best Lab Assistant!
Feeling on top of the world.
Can't recognize me?
Check out how detailed the event was planned. Siap with realistic props.
Finger Potion...Bulging Eyeballs. Hmm must be halloween approaching near.
How is that for a halloween inspired party idea?
Realistic looking bones and skulls
Even the drinks are in potion-like lab glasses. So thoughtful!Check out the other props. The hand soaked in the jar was the most realistic one to me.
The organizers were so creative when it comes to transforming this space to an eerie looking environment.
Guests were entertained by Igor looking creatures who danced the day away.
See Igor Dance here
Beautiful graphics to suit the theme. Great job, guys!
You Tube sensation Elizabeth Tan mezmerised us with her husky vocals.
Love her already. Beautiful and talented young lady.
Watch Elizabteh Tan here singing Havoc
and Fly Me to the moon here
Here's my winning moment
when I was declared as the winner for the best lab assistant photo contest.
I could not believe my eyes!
I won a 6 days trip to Korea and Saigon.
YAY! Double joy!
I will get to cover two countries and I am so looking forward for this trip next year.
For more crazy pictures of other participants, you can view it on instagram via #mpbscreenings2015
Lastly, a picture with the dua orang kuat from the TV Station before I left.
Encik Ahmad Idzham Omar, CEO of Primeworks Studio and
Ms Shareen Ooi, CSG Chief Marketing Officer TV Networks.
Round 2 Korea, here I come.
Will definitely share a travel blog when I return.


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Bella loves peanut butter. She eats peanut butter in or on everything- bread, yogurt, apples, bananas… she's asked for peanut butter with berries. So when I came across a recipe for peanut butter french toast, I knew we had to try it. For Bella's sake.
Turns out, peanut butter french toast is great. I've had it with maple syrup, vanilla syrup, and cream cheese and jam. If you like peanut butter and you like french toast, you will love this recipe!
Peanut Butter French Toast
2 eggs
½ c peanut butter
¼ c milk
¼ t vanilla
2 T honey
6 slices of homemade bread
butter to grease pan
Begin pre-heating your griddle or skillet to medium heat. I set my griddle on 350° F. Combine the eggs, peanut butter, milk, vanilla, and honey in a bowl. I've used my Magic Bullet knock-off for this; it blends the eggs better. Dip a slice of bread into the egg mixture, coating each side well.Place in the pan and fry until browned; flip and brown the other side.
This recipe makes about 6 pieces of french toast. Eat warm or
This recipe makes about 6 pieces of french toast. Eat warm or
cold! Bella thinks the leftovers make great jam and banana sandwiches.


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CRJ2006 Week 1 Assignment 3 Jury Trial
Updated 2016
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Here are a few of the larger projects I've worked on.
500 Lines is the fourth of the crowd-sourced AOSA book series, following on from The Performance of Open Source Applications and the two Architecture of Open Source Applications books. Each chapter is written by a different author, and describes a 500-line (or shorter) application. I was hired to copyedit the book and create a cover (and I helped out a bit with the publication process on Lulu). My work on 500 Lines was sponsored by PagerDuty: huge thanks to them!
Learn Scala for Java Developers is an introduction to the Scala programming language written for developers with experience working in Java. The author hired me to copyedit the book, and I did some stylistic editing too.
When Dr. Polimeni decided to publish a book about the evolutionary roots of schizophrenia, he enlisted me to help prepare and publish it. I edited, designed, and typeset the book, designed the cover, and engaged a proofreader and indexer to ensure it was as polished as possible.
The Architecture of Open Source Applications II was the much-anticipated follow-up to Volume I. Once again, it's a compilation of over twenty chapters describing the architecture of different open source applications. I coordinated the writing, reviewing and editing of the book, helped format it for print and designed the cover and layout.
The Architecture of Open Source Applications, or AOSA, is a compilation of over twenty chapters, each describing the architecture of an open source application. Each chapter was written by a different author and so the book contains a variety of prose styles, not to mention the numerous different image formats used for diagrams. My job was to take all those diverse chapters and make them into a cohesive and elegant whole.
The book has been greeted with enthusiasm by the open source community; volunteers are creating ebook versions, and translating the book into Japanese, Russian, Portuguese, Spanish and other languages.
An Uncertain Thing was a decade-long labour of love by Robert McCole Wilson. A retired teacher, he spent years researching and compiling references to children and childhood from sources including the Bible, classical Greek texts, and Dickens. When I came to the project it was an over-1000-page RTF document, which I formatted as a three-volume book using Microsoft Word. I created a cover and book design to give Mr. Wilson's work the showcase it deserved.


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Patent application title: Magnetic Relaxometry to Assess Disease via Circulating Markers
V. Gerald Grafe (Corrales, NM, US)
V. Gerald Grafe (Corrales, NM, US)
IPC8 Class: AG01R3344FI
USPC Class:
Class name: Surgery diagnostic testing measuring or detecting nonradioactive constituent of body liquid by means placed against or in body throughout test
Publication date: 2016-05-05
Patent application number: 20160124063
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Methods and apparatuses for detecting substances circulating in a
patient's blood are described. The substances, such as tumor cells, are
targeted with nanoparticles labeled such that they preferentially bind
with the substance of interest. As the nanoparticle-labeled substance
circulates, it can pass near a magnetic relaxometry system that can
detect the substance by detecting the nanoparticles bound to it.
1. A method of determining the presence of a substance of interest in the
circulatory system of a human or animal body, comprising: (a) providing
probes comprising nanoparticles conjugated with a targeting agent that
preferentially binds with the substance of interest in the body; (b)
introducing the probes into the body; (c) providing a magnetic
relaxometry measurement system configured to detect nanoparticles within
a measurement region of the system; (d) positioning the magnetic
relaxometry system relative to the body such that a portion of the
circulatory system of the body is within the measurement region; (e)
using the magnetic relaxometry system to assess the presence of
nanoparticles bound to the substance and within the measurement region;
(f) using the presence of nanoparticles to determine the presence of the
substance in the circulatory system.
2. A method as in claim 1, wherein providing probes comprises providing superparamagnetic nanoparticles whose magnetization decays by Neel relaxation from saturated to about 0.1 of saturated in 5 seconds or less.
3. A method as in claim 2, wherein providing probes comprises providing nanoparticles having a biocompatible coating, and conjugated to an antibody that preferentially binds to one or more types of cells.
4. A method as in claim 3, wherein the one or more types of cells comprises one or more types of cancer cells.
5. A method as in claim 3, wherein the one or more types of cells comprises one or more types of cells correlated with the presence, growth or metastasis of cancer.
6. An apparatus for determining the presence of a substance of interest in the circulatory system of a human or animal body, comprising: (a) A magnetization system, configured to impose a magnetic field upon a magnetization region comprising a portion of the circulatory system of a human or animal body; (b) A magnetic measurement system, comprising one or more magnetic sensors configured to measure a magnetic field at a plurality of times in a measurement region comprising a portion of the circulatory system of a human or animal body; (c) An analysis system, configured to determine the presence of superparamagnetic nanoparticles bound to one or more substances of interest from the magnetic field measurements and for the Neel relaxation properties of the nanoparticles.
7. An apparatus as in claim 6, wherein the magnetization system comprises one or more electrically conductive coils, and a power supply, wherein the power supply provides electrical current through the coils.
8. An apparatus as in claim 6, wherein the measurement system comprises one or more superconducting quantum interference devices.
9. An apparatus as in claim 6, wherein the measurement system comprises one or more atomic magnetometers.
10. An apparatus as in claim 6, wherein the magnetization system is configured to mount with an arm of a human body.
11. An apparatus as claim 6, wherein the measurement system is configured to mount with an arm of a human body.
12. An apparatus as in claim 10, wherein the measurement system is configured to mount with an arm of a human body.
[0001] This application claims priority to U.S. provisional 62/072,293, filed Oct. 29, 2014, which is incorporated herein by reference.
[0002] Magnetic relaxometry has been proposed to locate and measure solid tumors and other disease with fixed sites in vivo. See, e.g., PCT/US2010/055729; PCT/US2011/028746; PCT/US2011/039349; U.S. Ser. No. 13/870,925 filed Apr. 25, 2013; U.S. Pat. No. 8,447,379 issued May 21, 2013; each of which is incorporated herein by reference. The present invention provides methods and apparatuses for assessing disease expressed in cells or other substances circulating in a body.
[0003] Superparamagnetic nanoparticles are conjugated with antibodies or other targeting agents that preferentially bind to a disease marker, using processes known in the art and processes like those described in the references mentioned elsewhere herein. Targeting agents can comprise, as examples, antibodies that are specific to markers such as cell surface antigens on cancer cells, antibody fragments, small molecules, or any other substance that will bind the nanoparticle to a marker for disease. The specificity of the targeting agent contributes to the specificity of the invention. For example, nanoparticles using her-2 antibodies as a targeting agent will bind with cells expressing her-2; while nanoparticles using an EGFR as a targeting agent will bind with cells expressing EGFR, generally encompassing a greater number of cells and wider range of cell types.
[0004] The targeted nanoparticles (nanoparticles conjugated with a targeting agent) are introduced into the circulatory system of a subject, either animal or human. While in the circulatory system, if they encounter a fixed tumor (or other site with receptors for the targeting agent), the targeting agent will bind to the receptors and the nanoparticle will be effectively removed from circulation (at least for a time). If the site to which the nanoparticle was bound breaks free, e.g., a cancer cell breaks free of the fixed tumor and enters the circulatory system, then the nanoparticle will re-enter the circulatory system attached to the much larger cell.
[0005] If a targeted nanoparticle encounters a targeted site in the circulatory system, e.g., by encountering a circulating tumor cell, then the nanoparticle will be bound to the circulating cell and accompany it through the circulatory system.
[0006] The presence in the circulatory system of targeted cells (or other substances with receptors for the specific targeting agent) can be an indicator of disease. As an example, cancer tumors can shed cells into the circulatory system. The presence of such cells can indicate the presence of a tumor. Such circulating tumor cells can also be indicators that a tumor might metastasize to another location.
[0007] A magnetic relaxometry measurement system can be placed in proximity to the circulatory system of the subject. As an example, such a system can be placed on a wrist next to veins in that region. Other sites near blood flow can also be suitable. Such a system can also be made indwelling, and be placed within an artery or vein. Such a system can also be placed in an extracorporeal blood loop. The system can be mounted semipermanently, as with a wristwatch; can be mounted with clothing, such as gloves; and can be configured as a separate measurement device that is used to make measurements only when a subject is nearby. Since magnetic relaxometry involves measuring magnetic fields, it is generally preferable to place the sensors close to the region to be measured. If frequent, or near-continuous, monitoring is desired, then mounting such as with a wristwatch, can be preferable. The measurement system can also comprise communications with a remote system for control of the measurement system, data collection from the measurement system, analysis of data from the measurement system, or a combination thereof. For example, a wrist-mounted measurement system can be placed in wired or wireless communication with a smart phone or computer, wherein the smart phone or computer controls the measurement system and analyses data from the measurement system.
[0008] A magnetic relaxometry system involves a magnetization facility and a sensor facility. The magnetic characteristics of the nanoparticles determine the timing of the measurement. It has been found that iron oxide nanoparticles of about 25 nm in diameter are suitable for a measurement with a 0.75 second magnetization pulse followed by a magnetic field measurement over about 3 seconds. The 3 second measurement time allows Neel relaxation of nanoparticles that have bound to relatively large objects (such as cells) to be distinguished from randomization of magnetic moments to Brownian motion of nanoparticles that have not bound to such objects.
[0009] The blood flow characteristics of the region to be sampled can determine the configuration of the magnetic relaxometry system. The magnetization system and sensor system can be separated by a distance such that nanoparticles magnetized by the magnetization system are within the measurement region of the measurement system during the appropriate time after magnetization. Using the example numbers above, the sensor system can be positioned downstream from the magnetization system a distance that nanoparticles will traverse in about 0.5 to 3 seconds.
[0010] In operation, the magnetic relaxometry system can detect when nanoparticles bound to the targeted substance are in the measurement region of the magnetic relaxometry system. Such detection can be used for various purposes, depending on the targeting agent. As examples: (a) If a specific tumor antigen is targeted, then the detection of such tumor cells by the system can indicate that a tumor of that type is present, and that further tests are indicated. (b) If a tumor is known or suspected, then nanoparticles targeting that tumor type can be used. The nanoparticles will be expected to bind to the solid tumor at the fixed site. If bound nanoparticles are subsequently detected by the system, then it can be inferred that the tumor is shedding cells and possibly metastasizing, possibly indicating that more aggressive treatment is indicated. (c) A targeting agent that targets markers that are common to many disease types, e.g., EGFR or VEGF, can be used. The detection of those cells by the system can indicate that more specific tests are needed. (d) A plurality of targeting agents can be used, each specific to a type of disease to be monitored. The system can detect when any of the targeted cells or diseases have been encountered, providing a general screen for a plurality of diseases. More specific tests can be used to follow up a positive result from the more general screen.
[0011] Analysis of the results of the measurement can comprise various techniques. A basic magnetic relaxometry measurement can provide information concerning the number of bound nanoparticles that were present in the measurement region by determining the magnetic moment of the particles exhibiting the characteristic Neel relaxation. The system can look for any measurement above zero if a sensitive detection is desired. If the targeting agent targets a substance that is normally present, then the system can look for a measurement above a threshold, e.g., a predetermined threshold (as in the common PSA test) or a determined threshold (as when looking for an increase or decrease in the presence of a targeted substance). The system can also look for patterns in the measurement, such as variations that might correlate with time of day or physical exertion. The system can also look for frequency of occurrence, e.g. if a cell is detected once per day as opposed to once per hour. The system can also look for measurement changes following occurrences such as chemotherapy, specific diet choices or changes, other medications or therapies.
[0012] The magnetic properties of the nanoparticles can also be used to urge the nanoparticles, and especially the nanoparticles that have bound to targeted substances, to particular regions. For example, an appropriate magnetic field can be used to encourage nanoparticles to remain in the measurement region for extended periods. As another example, an appropriate magnetic field can be used to urge nanoparticles to the portion of the body that is being measured, e.g., an arm if a wristwatch-like configuration is used.
[0013] Using the magnetic properties to encourage the presence of the targeted substance in a predetermined region of the body can improve the effective sensitivity of the magnetic relaxometry measurement. If can also be used to enrich the region with the targeted substance, so that a blood draw for immunohistochemistry or other analysis can be done in that region and the effective sensitivity of that procedure also improved.
[0014] The presence of nanoparticles on the targeted substance can also be beneficial after blood has been drawn. The targeted substance can be preferentially removed from the blood sample for further analysis, for example by magnetic separation as described in PCT/US2010/0514417 and U.S. Ser. No. 13/399,733 filed Feb. 17, 2012; each of which is incorporated herein by reference.
[0015] FIG. 1 is a schematic illustration of the preparation of targeted nanoparticles. At the left is an iron oxide nanoparticle core 11, such as those available from Senior Scientific LLC, and currently marketed under the PrecisionMRX trademark (PrecisionMRX is a trademark of Senior Scientific LLC). In the middle of the figure is a depiction of an iron oxide core 11 with a coating 12 that fosters stability in aqueous environments and that allows attachment of targeting agents. At the right is a depiction of the coated particle with targeting agents 13 attached, ready for injection into the subject.
[0016] FIG. 2 is a schematic illustration of an example embodiment of the present invention deployed on the arm 22 of a subject. The magnetic relaxometry system 21 mounts in contact with the skin of the subject. The sensor portion of the system can mount in close proximity to the veins of the subject, to facilitate measurement of weak magnetic fields. Nanoparticles that have bound to targeted substances, when present in the measurement region 23, can be detected and measured by the system. The system can collect and analyze the data, or can communicate the date to a remote system (not shown) such as a computer or smart phone.
[0017] FIG. 3 is a schematic illustration of the placement of a magnetizing system and a sensor system in an example embodiment of the present invention. The subject is depicted with straight lines for ease of illustration. A portion of the subject is shown 32, e.g., an arm, leg, or finger of the subject. A blood-carrying element such as a vein or artery 32 is also depicted. A magnetic relaxometry system 33 is disposed next to the patient 31. The magnetic relaxometry system 33 comprises a magnetization system 35 and a sensing system 34. The magnetization system 35 magnetizes nanoparticles present in a magnetization region 37 of the patient. The sensing system 34 senses magnetic fields in a sensing region 36 of the patient. The magnetization system 35 and sensing system 34 are separated by a distance such that normal or expected travel of nanoparticles magnetized in the magnetization region 37 will position the nanoparticles in the sensing region 36 during the significant times in the magnetic relaxometry measurement. The separation shown in the figure is for illustration only; it is not to scale and the two regions can be closer together or farther apart, and can overlap in whole or in part. The magnetization system 35 can comprise any of a number of structures that impose a magnetic field one a region, such as various configurations of coils that carry electrical current to generate a magnetic field or permanent magnets. The sensing system can be any of various structures that sense low strength magnetic fields, such as sensors based on superconducting quantum interference devices and atomic magnetometers.
[0018] The present invention has been described in connection with various example embodiments. It will be understood that the above description is merely illustrative of the applications of the principles of the present invention, the scope of which is to be determined by the claims viewed in light of the specification. Other variants and modifications of the invention will be apparent to those of skill in the art.
Patent applications by V. Gerald Grafe, Corrales, NM US
Patent applications in class Measuring or detecting nonradioactive constituent of body liquid by means placed against or in body throughout test
Patent applications in all subclasses Measuring or detecting nonradioactive constituent of body liquid by means placed against or in body throughout test
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Akris is a Swiss label with a tradition of over 90 years. It is a traditional family business, currently run by the grandsons of its founder, Alice Kriemler-Schoch. It started as a small firm making dotted aprons, but it quickly developed and started making ready-to-wear clothing for women. Givenchy and Ted Lapidus were among its first customers and this was only a guarantee of its quality standards. According to the Akris Brand Profile, Albert Kriemler is in charge of the creative part of the company and his brother, Peter, of the financial side. Akris and Akris Punto are two main clothing lines of the company. The latter sells luxury, sports-inspired collections, while the first offers minimalist, elegant and exquisite quality clothing. The collections are shown during Paris Fashion Week. Also, Akris offers its customers special handbags and accessories. Since 2008, it took over the German bag manufacturer Comtesse which specialised in horse hair products. Therefore, one of its most special items is the Ai horsehair bag which is available in different colours. Akris pays special attention to the fabrics and materials it uses for its products, since it has very strict quality standards and is keen on maintaining them. The Akris clothes are described as spectacularly unspectacular and are dedicated to women who know how to wear them and who do not let the clothes wear them. Strong, confident women are the target group for this brand, which takes Swiss precision to another level.


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Pankaj Bhatia is the director of the GHG Protocol Initiative workstream within WRI's Climate, Energy, and Pollution Program (CEP). He is a leading expert on GHG Protocol Standards and tools, particularly in the area of corporate greenhouse gas (GHG) accounting and reporting.
Mr. Bhatia's work responsibilities include: overseeing the development of GHG Protocol product life cycle and supply chain inventory accounting standards; establishing GHG Protocol partnerships and programs in collaboration with businesses and governments in key developing countries; and providing advisory services in the design of emissions registries in the U.S. and internationally.
From 1998 to 2000, he was vice president of Tata Energy & Resources Institute, a not-for-profit research organization based in Arlington, Virginia and affiliated to The Energy & Resources Institute (TERI), New Delhi, India. From 1993 to 1998 he served TERI, New Delhi on various projects related to implementation of the Montreal Protocol in India and development of environment policy for technology transfer and capacity building in Indian industry.
He holds a Masters in process engineering from the Indian Institute of Technology, Delhi and Bachelors in chemical engineering from the Institute of Technology, Banares Hindu University, Varanasi, India.
About the GHG Protocol
The Greenhouse Gas Protocol (GHG Protocol) provides the foundation for sustainable climate strategies through its broad range of international accounting standards and tools. These tools enable governments and businesses to measure, manage, and report GHG emissions and performance, following consistent and credible international standards.
The GHG Protocol is a multi-stakeholder partnership of businesses, governments, NGOs, and others convened by the World Resources Institute (WRI) and the World Business Council for Sustainable Development (WBCSD). Launched in 1998, the mission of the GHG Protocol is to provide the foundation for sustainable climate strategies and drive more efficient, resilient, and profitable organizations through comprehensive GHG measurement and management.
Since 1998, the GHG Protocol has produced many separate but complementary standards and guidance through global, inclusive, multi-stakeholder processes including the Corporate Standard, Product Standard, Scope 3 Standard, and guidance documents for many sectors. It also provides a suite of Excel-based calculation tools that allow users to calculate their GHG emissions by entering activity data such as energy use, as well as detailed guidance for calculating emissions from various sources. Through the development of standards and tools, GHG Protocol has engaged with hundreds of global partners. Training and workshops on the different standards and guidance are regularly conducted around the world, with Programs or initiatives based on the GHG Protocol being pursued in India, Brazil, China, and Mexico. Current work under development includes Guidance for the Agriculture Sector and the ICT sector, City Accounting with the Global Protocol for Community-Scale Emissions, and Mitigation Accounting work.


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Very solid and enjoyable m/m mystery romance about Tom, a plumber with a special talent for finding what's hidden, whether it's a leaky pipe or a secret stash of porn, or when he's called in by his police friend, a murder victim in a park. Tom didn't ask for his "gift" though, nor is he happy when Phil (former handsome high school bully/now handsome private detective) is asking him to help find out who the murderer is. But things aren't always as they seem, especially when faced with a whole lot of old regrets, underfoot cats, retired porn stars, and a church full of suspects.
Tom's a great narrator for this mystery--a good mix of clever self-deprecating humor, self-awareness, empathy, and just enough cluelessness to be endearing to the reader (and frustrating to Phil, as he watches Tom effortlessly charm ladies and gents with just a smile and a "cheers, love.") Tom's finding talent also offers a nice paranormal twist to the mystery-solving, even if it doesn't always work in his favor.
Tom and Phil had great sexual tension and developing chemistry. The romance is a sloooow burn and this is very much a mystery story along with some yummy romance, but it all still felt satisfying. Also, very interesting side characters, especially Tom's very-gay BFF Gary, who was a riot in whatever scene he was in.
Tom's narration is *very British,* which sometimes meant I didn't always understand the slang, but it was still a blast to read, and his voice felt very down-to-earth and authentic. (This might be my 2nd favorite work by this author, next to the fantastic Muscling Through, another work with a very realized and authentic narrative voice.)
Overall, I thought this was a great mystery (and I couldn't figure things out before Tom did--always a plus), and a nice slow romance. If there was ever a sequel, I would definitely check it out. Recommended.


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High Court's Article 50 decision: how newspapers around the world reacted to the Brexit ruling
On Thursday, three senior judges ruled that the British government does not have the power on its own to trigger Article 50 of the European Union's Lisbon Treaty, the formal notification of Britain's intention to leave the bloc, a landmark judgement that could delay so-called Brexit.
The ruling has provoked an outcry across the country which was reflected by Friday's front pages.
The Daily Telegraph: The judges versus the people
Daily Mail: Enemies of the people
The Times: May is urged to call snap election over Brexit ruling
Express: We must get out of the EU
Guardian: Turmoil for May as judges rule that Parliament must decide on Brexit
Daily Mirror: Odds slashed in 2017 election
Financial Times: May's Brexit calendar in turmoil as judges rule MPs must have say
i: Brexit plan in tatters
The Sun: Who do you think EU are?
International press
Wall Street Journal (US): Ruling puts twist in UK exit plans
El Pais (Spain): May won't be able to activate Brexit without Parliament
South China Morning Post (Hong Kong):
Le Figaro (France): Brexit: British law complicates Theresa May's task
Corriere della Sera (Italy): Judges Put The Brakes on Brexit
Dagens Nyheter (Sweden)
"Few court decisions have shaken the British political establishment like that of the High Court in London," noted Sweden's Dagens Nyheter.
It suggested that UKIP would be the biggest winner, and quoted Sweden's EU minister Ann Linde saying that it risked causing a damaging delay.
"The negative effect is that political and economic uncertainty will continue. But if the the delay means a 'softer' Brexit, that is positive for Sweden, for we have an interest in as good and close relations with the UK as positive."
- In the Netherlands, The Telegraaf popular right-wing paper calls it 'a major setback for Theresa May's Conservative government'


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Ohio Gunsight Concealed Carry Class
632 Canton Rd.
Akron, OH 44312
ph: 330-784-3422
At Ohio Gunsight, our training course is superior to many CCW courses currently being offered by other facilities.
Our training course meets and exceeds the State Requirements for Certified Instruction, and will take you step by step through the process of learning how to shoot if you are a beginner, or how to become a BETTER shooter, if you are an experienced shooter. Advanced self defense ideas ARE introduced.
A Concealed Carry Permit is not difficult to obtain, even if you have never fired a handgun!
About our classes:
A VERY HIGH EMPHASIS is placed on Safety, and on Handgun Shooting
Our instructors are NRA Certified, and follow the guidelines set by the State of Ohio.
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• You DO NOT have to be an NRA member to take this training course!
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About the Instructors :
Bryon Little :
Firearms Experience:
35 years experience Handgun shooting.
NRA Certified Instructor - Rifle and Pistol
NRA Handgun Distinguished Expert.
Concealed Carry Weapons Permit Holder
Teaching Experience:
• 35 years teaching experience
• 7th Degree Black Belt in Martial Arts - Master Instructor, teaching Self Defense / Martial Arts to Men, Women and children of all ages.
Rick Stein :
Firearms Experience:
30 years experience Handgun shooting.
NRA Certified Instructor - Pistol
Concealed Carry Weapons Permit Holder - Ohio
Handgun Shooting Competitor – Ohio
Federal Firearms Licensed Dealer -FFL
Glock certified Gunsmith
Teaching Experience:
* 13 years teaching Concealed Carry
Ohio Gunsight Concealed Carry Class
632 Canton Rd.
Akron, OH 44312
ph: 330-784-3422