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Yet another talent from the Black Butter Records' family. The dynamic duo from London; Primo and Thomas, make grimey bass anthems. We'd like to believe that they were inspired by the likes of Redlight and the early years of Dark Sky. Seeing that the sound is very reminiscent of these two giants - that's also exactly what you can expect. Epitomising the London/UK bass sounds that we're big fans of, we were excited to find out more about these new talents! They were nice enough to do a short interview with us:
Favourite Track: Syv - Knockin'
Explain your sound to us? How would you describe it?
We find it hard to actually describe the sound we make, but I'd just say its bass driven music with a musical element. By that I mean that we always felt that club music didn't really pay attention to other sections of the track apart from the ''drop''. Most tracks would start with a 4/4 drum beat and progress in a samey boring kind of way. Our kind of aim with tracks at the moment is to start a track in one place but then take you somewhere completely different seamlessly and I guess you could say thats our vibe.
If someone asked to listen to just one track of yours, in order to understand your music better, which tracks would it be and why?
Without sounding pretentious I feel like if you hear an Syv record you know its an Syv record purely because our sort of trademark intros and vocal chops/sampling & wonky drums. I feel like every producer has their own unique way of doing the same things and that's really what separates artists from one another.
Which of your own productions are your personal favourite (and why)?
I honestly feel all this new stuff we are sitting on (which you'll be able to hear soon I promise) is our strongest material yet. We're just experimenting more with sounds & manipulating sounds and the more we experiment the better our productions are getting.
If you could collaborate with anyone world-wide (and resources weren't an issue), who would it be and why?
Missy Elliot hands down. I have so much respect for Missy and always have. Just her vibe alone would sit so well on an Syv Record.
What's the one thing that you absolutely love about the music scene at the moment? That reminds you every time why you chose this profession?
I think the thing that we love the most is the people we're surrounded by. There's loads of family-type vibes in the industry, which I love. For example, the bristol lot feel like family. Especially the SOBAD crew, Which is a new collective featuring my favourite artists in the game right no; Sly One, Bromley, Archive and Distro. Pretty much all the tracks i'm playing in my sets now are made by my mates. Not because they're my mates, but purely because we are all just on the same wavelength and love each others tunes. I love that.
What's the one thing you're cringing about at the moment, when it comes to the music scene? Something that (almost) makes you want to stop?
I wouldn't say anythings really cringing me out but I feel like too many people are playing it safe. Producers, Labels, Events, everything! I don't feel like many people are putting out music that isn't within the lines of something thats already successful. Also, the people who are aren't getting the attention that they deserve. 2015 was the rebirth of M1 House Piano and The M1 Organ Bass with any old classic r&b acapella chucked on top. That bores us. There is so much good music out there, but you'll only find it if you properly dig for it.
What's the biggest misconception people have of the music industry?
The 1 Million Pound Record Deal.
What can we expect from you in 2016?
So many different vibes of music, collaborations and ridiculous shows including one in Amsterdam next month, where I hope to catch some of you!
What's your opinion on the rise of the UK genres in USA?
I love the cross over but UK music will always stand out as UK music. Every country has their own take on a scene but it'll always be different no matter how hard they try. I look at it like other countries may be able to speak English but they will always have an accent of where they're from. By this is mean that no matter if they try to make UK music elements of where they're from will leak into it subconsciously.


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Seven more people were sentenced at Swindon Crown Court yesterday, 12 July 2018, for their part in a large money laundering conspiracy.
This follows on from the sentencing of seven others on 4 June 2018 involved in the same case; between August 2014 and September 2015 the main offender, Aaron Kennett, 28, an employee of JB Global Ltd (trading as Oak Furnitureland) of Avening Street, Swindon fraudulently issued refunds via bank cards.
Effectively issuing 'free money' Kennett typed friends and associates bank details into a card machine in order to provide a refund which was not due and did not match any sales record.
A meticulous investigation with JB Global uncovered the extent of the fraud totalling £213,447.17. Enquiries into phone records and bank transactions revealed links between Kennett and his associates; photos were discovered of members of the group enjoying holidays worldwide paid for with the stolen money while others used it for expenditure and to fund gambling habits.
34 people, all from Swindon, were arrested or summonsed in connection with the conspiracy. Nine people were released with no further action, five were given cautions and six others were dealt with at Magistrates court and were issued with suspended sentences, fines and community orders.
Kennett was charged with Fraud by abuse of position and Conspiracy to conceal, disguise, convert, transfer criminal property (Conspiracy to money laundering) he pleaded guilty on the first day of his trial and was sentenced to four years and six months in prison on 4 June 2018.
Six others were also sentenced on the same day.
The following were charged with conspiracy to money laundering and were sentenced at Swindon Crown Court:
Lewis Turner (25) from Castle View Road, Chiseldon – money laundering and possession with intent to supply class A drugs - 2.5 years imprisonment and surcharge of £170.
Nina Turner (50) from Castle View Road, Chiseldon - 12 month community order, 20 days rehabilitation, £140 surcharge.
Mark Melhado (51) from Isambard Way, Swindon - 16 months imprisonment suspended for two years, 40 hours unpaid work, 20 days rehabilitation. Surcharge £120.
Marcel Douglas (28) from York Road – 10 months imprisonment suspended for two years, 100 hrs unpaid work and £1200 compensation.
Liam Porteous (28) from Thurney Drive, Swindon – 18 months imprisonment suspended for two years, 100 hours unpaid work, £140 surcharge.
Robert Porteous (54) from Crawford Close, Swindon – Community order 12 months. 100 hours unpaid work. £400 compensation.
Marvin Porteous (32) from Beaulieu Close, Swindon – 14 months imprisonment suspended for two years, 100 hours unpaid work, £140 surcharge.
DC Bev Mobey said: "This is the conclusion of a long, complicated case and I am pleased that the remaining seven in this case have been dealt with.
"Thanks to strong collaborative work between us, Oak Furnitureland and Barclaycard we have been able to put together overwhelming evidence of their guilt and bring all 14 before the courts.
"I hope this acts as a deterrent for anyone who may consider this course of action in the future."
A spokesperson from Barclaycard said: "Protecting our customers' money is our top priority and we have a zero tolerance approach to fraud.
"As in this case, we continue to provide every assistance to the local police to enable them to prosecute suspected fraudsters."


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a winter accessory (who are we kidding? Necessity) gone MIA
The snow packed in around my car was almost three feet wide from the side of my car to the street, and the pile hit about midway up the side of my door. It was a disaster. I fetched the shovel from my backseat and started the car from the passengers side (no use trying to open the driver's side door) and proceeded to start digging out. Half and hour went by and I hadn't really made a dent in all the snow, partially because I couldn't just push it away from the car and had to cart it around to the other side of the car to dump it. At the start of my shoveling I found myself thinking about how much I want a garage. A covered structure so I don't have to scrape my windows, or get all of the snow off of Kennedy before I go somewhere. This thought progressed to how nice it'd be to have a garage AND a boyfriend/husband who liked to use our snowblower. Then I got to thinking about how great a garage, boyfriend/husband, snowblower AND plow truck would be. I decided that it'd be decadent.
(truth be told I've always wanted to drive a plow; not one of those "do it yourself" plows, but a real "city-issued" flashing lights and sand things attached plow truck. I can only imagine what it's like to drive around knowing that you won't slip off the road in even the worst of storms!)
I continued to dig, push and rearrange the snow around my car, becoming more and more aware that the chances of me getting to class within the first hour were slim to none; but then I heard it: the starting of a snowblower. I looked wistfully around to see if I could figure out where it was, and saw a guy walking towards me from across the street with a knowing look on his face. He didn't say anything, but got to work getting the bulk of the snow blown away from my car (and into the street). I felt bad about the snow getting spread across a lane of (non-existent) traffic, but I got over it when it took him 5 different passes to get the bulk of the snow moved. (what took him two minutes to do would have had me there for another hour!) He said, with a smile, "that ought to help!" then headed back to his truck to put his toy away.
Life was good until I saw a massive, huge, heavy piece of construction equipment (think back-end loader or something equally as HUGE) with a super sized plow/bucket attachment headed toward my car. The driver had obviously spied the snow in the street and he was here to plow it. I rushed around making sure I had my shovel and window scraper, jumped into the car and started to maneuver myself out of the cramped and still not totally cleared out parking spot. It was tight, and took me a good dozen shifts from drive to reverse and back again, while rocking back and forth and trying to get traction. It was a mess.
Eventually I pulled out of the spot and into traffic, and it wasn't long before I was on the clear interstate on my way to school. I pulled off my wet mittens and put on a dry pair and reached up to take my hat off.
But I wasn't wearing a hat anymore.
It was gone. I thought perhaps I had pulled it off and thrown it in the car with the shovel, and so I crossed my fingers and checked when I got into school. It was no where to be seen.
My noro hat is MIA.
The noro I bought for it was my first ever "real" yarn purchase, and the reason I fell in love with it was because the yarn store had a simple hat knit up with the yarn. I hated to spend over $8 a pop for it, but I couldn't leave it in the store. I loved it – I loved how the colors bled into each other, and how the blues and purples and greens all matched.
I knit that hat three times – once it was too small, and when trying to make it "bigger" on larger needles I made it so big that I ran out of yarn. The third time was the charm, and I figured out what "gauge" meant. It was warm, and I always got complements when I wore it. I just in the past few months got around to seaming it; I worked on it over the course of a few months, and unpacked it (from move #4) last fall.
It will be missed.
(I will keep my eyes peeled for what the melting snow revels, but I'm not holding my breath. The plow guy cleared my spot out and it's obvious where I was parked this morning; I walked over and didn't see anything except lots and lots of snow.)
I'm taking bets on when the last of the snow will be gone - as in, there is no snow anywhere outside my window; for reference it's 18 degrees outside (in what's left of the sun) and tonight we'll hit a high 7 degrees. More snow is expected Friday night and we've been known to have April storms. (the post on why I love the northeast will appear at some point; I'm a bit bitter to try and compose it right now!)


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Funded Research
2017 Funded Projects
Congratulations to the successful applicants in this year's Major Projects Round. Once again, the caliber of applicants was very high and our sincere thanks go to our Scientific Advisory Committee led by Professor Margreet Vissers, who take significant time out of their research and clinical work to assess all incoming applications for us.
Dr Khoon Lim (University of Otago, ChCh) Engineering Cartilage Constructs using 3D Bioassembly
Articular cartilage has a limited regenerative capacity, and few approaches employed are clinically capable of restoring long-term function. This research is focused on bridging the gap between regenerative medicine and the clinic by developing improved cell therapy strategies and advanced 3D printing scaffold technique for repairing damaged cartilage.
Dr Cameron Lacey (University of Otago, Christchurch) Pilot RCT of Activation Therapy for Inpatient Depression
Patients with severe depression who require admission to an psychiatric unit usually have serious impairment in many areas of functioning, particularly cognitive function (memory, concentration, planning). We have designed Activation Therapy (AT), a package of psychological treatment combining cognitive activation (targeted computerised cognitive exercises to improve cognitive performance) with behavioural activation (scheduling and encouraging activity to improve mood). We believe this treatment package may improve outcomes for in-patients with depression, particularly cognitive functioning and general functioning, may speed up mood recovery and reduce the likelihood of re-admission.
Dr Martina Paumann Page (University of Otago, ChCh) Assay development for a protein implicated in metastaticmelanoma
Peroxidasin is a protein found in most tissues in the human body. Its physiological function was discovered only recently and so far its contribution to health and disease is poorly understood. There is evidence that peroxidasin plays an adverse role in certain pathologies. Peroxidasin was shown to be upregulated in numerous types of tumors. Moreover it was identified to be vastly elevated in metastasizing melanoma skin cancer cells. Peroxidasin also appears to be involved in tissue fibrosis. Peroxidasin is a protein found in most tissues in the human body. Its physiological function was discovered only recently and so far its contribution to health and disease is poorly understood. There is evidence that peroxidasin plays an adverse role in certain pathologies. Peroxidasin was shown to be upregulated in numerous types of tumors. Moreover it was identified to be vastly elevated in metastasizing melanoma skin cancer cells. Peroxidasin also appears to be involved in tissue fibrosis.
However, the underlying molecular mechanisms are largely unknown. To date there are no assays available to detect peroxidasin protein and activity. To study the involvement of peroxidasin in melanoma we will develop specific methods to measure peroxidasin in various biological samples, therefore providing important tools to improve our understanding of the reactions of peroxidasin and its implications in health and disease.
Ms Jennifer Crowther (University of Canterbury) Towards the development of a bioassay for the early detection of pre‐eclampsia
Pre-eclampsia, a hypertensive disorder, is a potentially life-threatening condition that develops in 2 – 7% of all pregnancies worldwide. Currently, the only option in severe cases is the early delivery of the baby. Symptoms usually subside for the mother within days of giving birth, but early delivery comes at the expense of the health, or even life, of the child. Earlier intervention strategies allows prolongment of the pregnancy, improving health outcomes for the mother and baby.
Dr Nicola Scott (University of Otago, ChCh) Phosphodiesterase 9 inhibition as a novel therapeutic strategy in heart failure
Heart failure (HF) remains a leading cause of death and disability in New Zealand, and new treatments are needed. The natriuretic peptides (NPs) are hormones whose actions alleviate the symptoms of HF and delay its progression.Regulating the activity of the NPs is phosphodiesterase 9 (PDE9), an enzyme that reduces NP signalling and is elevated in HF in association with blunted NP activity. With increasing evidence indicating PDE9 contributes to HF worsening, we hypothesise that inhibition of the PDE9 enzyme will restore NP efficacy with resultant beneficial effects. Our research aims are to explore PDE9 inhibition as a treatment strategy in HF.
Dr Sarah Appleby (University of Otago, ChCh) Myoregulin: a secret code underlying heart disease
Cardiovascular disease remains the leading cause of death in New Zealand, necessitating new biological markers that will aid in earlier diagnosis, treatment or prognosis. Recently, a potential untapped source of these markers has arisen from what was previously thought of as "junk DNA", but has now been found to produce functional proteins. This project will explore one of these novel proteins, myoregulin, which is thought to control calcium levels in muscle cells. Keeping calcium levels balanced in the heart is extremely important for normal heart functioning, thus, myoregulin may be an important regulator of heart function.
Dr Patrice Rosengrave (University of Otago, ChCh) The effect of vitamin C administration on long-term physical and mental health outcomes of survivors of sepsis.
Sepsis is a life-threatening condition that is widely defined as a systemic inflammatory response to severe infection resulting in multi-organ failure, and is leading cause of mortality in critically ill patients. Many survivors of sepsis have substantial long-term physical, cognitive, and psychological impairments, also known as Post Intensive Care Syndrome. Our data indicates that patients with sepsis have very low vitamin C levels. Previous studies in cancerpatients have highlighted the role that vitamin C plays in improving patients' quality of life. Therefore, we hypothesise that vitamin C administration to survivors of sepsis after discharge from hospital will aid in their recovery by improving physical functioning and performance, as well as their mental health.
2016 Funded Projects
Dr Anitra Carr (University of Otago) Intravenous Vitamin C and severe sepsis outcomes - randomised controlled trial
Sepsis and septic shock are caused by a systemic inflammatory response to severe infection that results in multiorgan failure and refractory hypotension. The incidence of severe sepsis is increasing and is the leading cause of mortality in critically ill patients. Preliminary data indicates that sepsis results in significant depletion of vitamin C levels and a recent Phase I study demonstrated that administration of vitamin C to patients with severe sepsis dramatically improved inflammatory biomarker levels and clinical outcome measures. Vitamin C acts as a cofactor for numerous regulatory and biosynthetic enzymes, including those responsible for vasopressor synthesis. Therefore, we hypothesise that vitamin C administration will improve sepsis-related disorders such as hypotension through its enzyme cofactor activities. This Phase II randomised controlled trial will assess the effects of vitamin C infusion on hypotension and vasopressor requirements, as well as markers of oxidative stress, inflammation and leukocyte activity, in patients with severe sepsis. The biochemical mechanisms of action will be determined by measuring a suite of clinically-relevant and novel cofactor activity biomarkers. Overall, this study will establish the efficacy of vitamin C in improving clinical outcomes in the critically ill. You can read Anitra's full research profile here and her final report here
Dr Rachel Purcell (University of Otago) Contribution of enterotoxigenic Bacteroides fragilis to colorectal carcinogenesis
Colorectal cancer is a common type of cancer, and while recent evidence suggests that gut bacteria may increase risk, the exact mechanisms remain elusive. Bacterial infections can cause chronic inflammation, which has been linked to cancer development. The Bacteroides fragilis toxin potentially alters intracellular signalling pathways that are also linked to cancer development. We will explore how chronic inflammation as a result of enterotoxigenic B. fragilis (ETBF) infection is associated with development of colorectal cancers, including whether genetic mutations arise as a result of this chronic inflammation. We will also investigate the role of microRNAs as a potential mechanism that regulates this process. MicroRNAs are small RNA molecules that do not code for proteins, but have recently been shown to play important roles in many cellular processes, including the development of cancer. We hope that this project will identify novel markers for the early detection of colorectal cancer. You can read Rachel's full research profile here.
Dr Andree Pearson (University of Otago) Measurement of Mitochondrial Function during Human Ageing
Human life expectancy has increased considerably in the last century, but along with this advance has come the increased burden of age-related disease and disability. Interventions that promote healthy ageing are limited, and new advances will depend on improved understanding and measurement of the underlying biological processes. Mitochondria are the site in our cells where food is converted into energy. Mitochondrial dysfunction isclosely linked to ageing, however there is an absence of non-invasive methods for measuring mitochondrial function in humans. We will attempt to use new technology to measure the health of mitochondria in cells isolated from a small blood sample. We will compare mitochondrial function in an elderly population with that of a younger population, and also examine how effectively the antioxidant defences of ageing mitochondria cope with an oxidative stress. This project will provide insight into the biological processes underlying human ageing, and methodology to measure these processes in the general population.
Dr katie Douglas (University of Otago) Pilot Study of Cognitively-Enhanced Interpersonal and Social Rhythms Therapy for Depression
Major depressive disorder (MDD) involves significant morbidity, suicide risk, and recurrent hospitalisations. After recovery from a depressive episode, individuals often continue to experience problems with cognitive (i.e., thinking, organisation, memory) and general functioning, and report these problems to be distressing and disabling. Treatment of severe depression in New Zealand involves short-term treatment by Specialist Mental Health Services (SMHS) then discharge back to primary care. Following discharge, readmission to inpatient and outpatient services is very common. We are therefore interested in developing a treatment for people with severe depression that could be used to aid in cognitive and functional recovery following discharge from SMHS. You can read Katie's full research profile here.
Dr Margaret Currie (University of Otago) Does exercise lower systemic inflammation and improve chemotherapy efficacy in cancer patients?
Obese cancer patients tend to respond more poorly to chemotherapy and have more rapid disease recurrence and shorter survival times. One reason for this is that obesity leads to low-level chronic inflammation that fuels the development and spread of cancers. Little is known about how this systemic obesity-related inflammation affects the way cancer patients metabolise chemotherapy drugs. Therefore, this project aims to (1) measure circulating inflammatory proteins that may be used to identify patients who will respond poorly to chemotherapy and are at high risk of worse survival, (2) use cell culture studies to explore the way obesity-related inflammatory proteins may alter chemotherapy drug metabolism by the liver, and (3) perform an exploratory patient study that will use fitbits to monitor exercise during chemotherapy treatment, as well as measure circulating inflammatory proteins, patient liver enzyme activity and drug metabolism, and patient well being during treatment. This project will form the basis for ongoing studies at the University of Otago Christchurch into the potential benefits of moderate exercise during chemotherapy treatment. You can read Margaret's full research profile here.
Dr Prisca Mbikou (University of Otago) Role and therapeutic potential of the novel DWORF peptide in heart disease
Heart disease (HD) is a leading cause of death and disability in New Zealand, and new treatment options are needed. A recent breakthrough in genetic research concerning so-called non-protein-coding RNA has led to the discovery of a new class of proteins, one of which is called dwarf open reading frame (DWORF). This small protein is found almost exclusively in the heart where it may cause increased contraction of the heart muscle. DWORF levels are decreased in the hearts of people who have had heart attacks, suggesting it plays a role in the development of HD and may have potential as a treatment for restoring the impaired beating of damaged hearts. However, exactly how DWORF works and the effect on the heart of directly administering the protein is unknown. The goal of this research project is to investigate the effect of DWORF on heart function in normal and damaged hearts (using an ex vivo rat heart attack model), its levels in the heart in both settings, what proteins it interacts with, and how it operates. These highly original studies will further our understanding of this unique protein and might help in the development of a novel treatment strategy for HD. You can read Prisca's full research profile here.
Dr Kristin Lamvik (University of Canterbury and Rose Centre for Stroke Recovery and Research) Reliability, validity and clinical application of temporal and amplitude analyses using pharyngeal highresolution manometry
After stroke, the majority of patients will experience difficulties swallowing, termed dysphagia. This is a critical impairment as it can place patients at increased risk of developing chest infections or even facing an increased risk of death. Thus, the proposed research programme will provide directives for refining the use of evaluation tools in the clinical assessment of swallowing problems. This is will be done by investigating a technique termed manometry, which measures throat pressure when swallowing.
Manometry is important because it is one of the only ways to measure swallowing objectively, however, there is disagreement on the most valid and realiable way to analyse manometric data. The results from this study will have great importance both locally and globally. In Christchurch alone, there are two manometry systems used in clinical practice, one of which operates in the busy Christchurch Hospital. Thus, the results of this project will lead to an immediate improvement in patient care, helping to keep patients safe and swallowing effectively. You can read Kristin's full research profile here.
2015 Funded Projects
Major - Projects
Vitamin C requirements in Severe Infection - Dr Anitra Carr
Severe infection which results in a systemic inflammatory response (sepsis) is the leading cause of death in critically ill patients. The incidence of severe sepsis is increasing, and the outcome is poor, with mortality rates as high as 30-40%. Recent studies indicate a potential role for vitamin C in ameliorating severe infections (such as pneumonia) and sepsis. Vitamin C is a potent antioxidant and has potential anti-inflammatory properties. Preliminary research indicates that patients with sepsis have decreased vitamin C levels. The purpose of this study is to assess the levels of vitamin C in patients with pneumonia and sepsis over the duration of their stay in intensive care and to correlate these with levels of inflammatory biomarkers and patient outcomes. Vitamin C may prove to be a useful biomarker for the severity and progression of sepsis and the extent of deficiency of these patients will indicate requirements and will be used to inform the design of future clinical trials.
Red bloodcell vitamin C: a useful indicator of patient ascorbate status? - Dr Juliet Pullar
Vitamin C is an essential requirement of the diet in humans due to the evolutionary loss of the ability to synthesise it in the body. Vitamin C status is typically measured in a fasting-blood sample, which can be difficult for some people to provide, particularly those who are unwell. The aim of this project is to establish a method for measuring vitamin C status in non-fasting individuals using red blood cells. We will firstly optimize a procedure for assessing red blood cell vitamin C levels, and then measure the red blood cell vitamin C status of a group of surgical, sepsis and cancerpatients at Christchurch Hospital. Overall, this study will determine whether non-fasting red blood cell vitamin C levels are a reliable measure of patient vitamin C status.
The effects of resveratrol's derivatives on VEGF, IL-6, IL-8 and NF-kB in ovarian cancer in vitro and in vivo studies -Dr Kenny Chitcholtan
Women with advanced ovarian cancer normally have a poor outcome because the tumour has spread within the abdominal cavity at the time of diagnosis. Most women with advanced disease show the sign of building up ofbody fluid; this becomes a clinical challenge for the current treatment management. Treatments currently available can prolong time of survival, but tumours become resistant to treatment and a cure is rare. In order to prolong time of patient survival, a new form of anti-cancer drugs, showing less side effects and being low cost, is urgently needed. Resveratrol is a food compound and has been found to show anti-tumour activity in a laboratory. But its anti tumour activities are uncertain in humans because resveratrol is highly metabolized and rapidly secreted from the body. Therefore, compounds that are structurally related to resveratrol may be useful to investigate their anti-tumour activities in human. We are very interested in derivatives of resveratrol and we want to investigate if these derivatives can exhibit anti-cancer activities in a laboratory before we could use them in humans.
RNA isoform profiling of breast cancer susceptibility genes - Dr Logan Walker
Routine diagnostic BRCA1 and BRCA2 gene screening for deleterious mutations is typically performed for individuals from suspected high-risk breast-ovarian cancer families to identify the genetic cause for their disease. However, for most women with breast and ovarian cancer, the genetic changes contributing to their disease remain poorly understood. High-throughput genomic technologies are now being adopted by diagnostic laboratories worldwide, enabling mutation screening of BRCA1 and BRCA2, and other cancer related genes in a greater number of people. Determining the clinical meaning of newly discovered genetic changes will be a central challenge facing the future of genomic medicine. We will apply two powerful new technologies to measure the expression behavior of BRCA1 and BRCA2 activity in breast tumours from patients with and without a strong family history of cancer. Our proposal will assess if the inherited mutation status of these genes disrupts their behavior. Furthermore, our proposal will generate the first comprehensive gene expression profile of BRCA1 and BRCA2 in familial and non-familial breast tumours. The new knowledge derived from this proposal may facilitate the development of genomic-based protocols to evaluate genetic changes responsible for breast cancer and other inherited diseases.
Mycoplasma genitalium macrolide and fluoroquinolone - Dr Anja Werno
Mycoplasma species are the smallest free living bacterial forms. Mycoplasma genitalium is accepted as a human pathogen causing infections including urethritis and cervicitis. The first-line treatment of M. genitalium infections isazithromycin and in cases of treatment failure moxifloxacin is used. M. genitalium cannot be routinely cultured in the clinical laboratory and requires molecular techniques such as real-time PCR for detection and DNA sequencing to test for antibiotic resistance. The aim of this study is to evaluate whether the resistance rates warrant introduction of routine molecular resistance testing to assist with patient management. Monitoring of resistance rates will be useful to advise long-term treatment strategies around non-specific urethritis/cervicitis.
Identifying candidate RNA biomarkers for coronary artery disease - Dr Anna Pilbrow
Coronary artery disease (CAD) is a very common form of heart disease and is a leading cause of death in Canterbury. CAD develops when cholesterol-containing deposits (plaque) accumulate in the coronary arteries. As plaques build up, they decrease the flow of blood to the heart muscle, which can cause chest pain or a heart attack. The rate at which plaques build up varies between people making it difficult to identify those who may be at risk of a heart attack in the near future. Our research aims to identify new blood biomarkers for the presence of coronary artery disease, to allow screening and early detection of those at risk. Specifically, we will use a high-throughput genomics technology called next generation sequencing to measure levels of a newly-discovered class of molecules called long noncoding RNAs in 12 patients with stable coronary artery disease and 12 healthy controls from Canterbury. This in-depth screening study will help us identify candidate biomarkers to test in our existing, large cohorts of healthy volunteers and CAD patients in the future. Ultimately, our research may contribute to the development of new blood tests that will help predict those at impending risk of a heart attack.
Pilot study of biomarkers of outcomes from anticoagulants - Dr Paul Chin
Dabigatran (Pradaxa®) is a relatively new blood thinner medicine that is used to prevent clots. It was used in over 2,000 Cantabrians in 2014, and over 15,000 nationally. The main side-effect is bleeding. Dabigatran is currently used without any blood tests to check for the level of blood thinning. High levels of blood thinning may lead to bleeding, whereas low levels may lead to clots and strokes. Our study aims to find the ideal level of blood thinning with dabigatran. We will do this by doing blood tests on people taking this medicine, including those having clots and bleeds, as well as those who are well. In the future, knowing the ideal level of blood thinning with dabigatran will enable dabigatran doses to be adjusted so that high and low levels may be avoided.
C-Type Natriuretic Peptide and Renal Dysfunction - Dr Tim Prickett
Renal function is a major determinant of prognosis in patients presenting with heart failure or coronary artery disease. Recently we have discovered that fragments of a precursor molecule of C-type Natriuretic Peptide (CNP)are raised in blood as renal function begins to decline. Whether these changes result from diminished clearance or increased production by the kidney is unknown. The molecular identity of these peptide fragments and changes to their relative abundance in blood and urine in the failing kidney is unknown. The objectives of this proposal are twofold. Firstly, to identify the specific products of CNP gene expression in urine and plasma and thereby measure their clearance and renal production rates in health. Secondly, to measure both renal CNP production and clearance before, during and after induction of early renal and cardiac impairment induced by rapid ventricular pacing in 10 sheep. Collectively these studies will illuminate the mechanisms that lead to changes in CNP during the early phase of cardiac and renal impairment and may identify novel prognostic biomarkers suitable for detecting early renal failure (and implementing corrective treatments) in subjects with cardiovascular disease.
Amyloid and cognitive predictors of dementia in Parkinson's - Dr Tracy Melzer
Cognitive decline and dementia are now recognised as an essential part of Parkinson's disease, which ultimately becomes the most burdensome aspect of this disease. We know that those exhibiting mild cognitive impairments are at increased risk for developing dementia, but we have established that some individuals not showing cognitive impairments also exhibit increased risk. Here, we will perform advance positron emission tomography (PET) and MRI scans, and clinical evaluation in Parkinson's patients with both high and low risk for developing dementia. We will determine whether PET imaging adds further information about an individual's risk of future dementia. This will advance our understanding of this important issue and establish a useful and reliable tool for researchers and clinicians. It is critical that we can do this so that preventative treatments to protect against dementia can be targeted at the most appropriate patients when that treatment becomes available and also to select the right "at risk" Parkinson's patients for trials of new treatments.
Pilot of methods to measure unmet secondary healthcare needs - Dr Phil Bagshaw
We have information on people who are treated in hospital but it is difficult to know how many people have health needs that are not being met. We know that some health services are over-crowded and that, over the last twenty years, a number of policies have limited peoples' access to non-urgent care. This project will trial three population survey methods, and a method of getting information from GPs, to establish a reliable method of measuring unmet healthcare need in the community. We plan that in the future we will be able to measure unmet-need to assess the ongoing performance of the health system.
Special - Projects
An investigation into the possible linkages between Vitamin C, Hypoxia and Cancer in Breast Cancer. Proposed analysis of Human Breast Cancer Tissue. - Professor Margreet Vissers (a jointly funded project with the NZ Breast Cancer Foundation)
The team will recruit breast cancer patients into future clinical studies, but first need to determine whether the inverse relationship between tumour ascorbate, the hypoxic response and tumour growth also applies to breast cancer. The team will carry out the analysis of a cohort of Tissue Bank breast cancer samples to determine whether the HIF-1 and ascorbate relationship exists in these tissues.
Projects Archive
Here you can read the final reports from most of the CMRF-funded projects from the past few years.
Dr Logan Walker, University of Otago - RNA isoform profiling of breast cancer susceptibility genes
Dr Anitra Carr, University of Otago - Intravenous Vitamin C and severe sepsis outcomes - randomised controlled trial
Dr Dean Harris, Christchurch Hospital - Potential biomarkers of 5FU cardiotoxicity
Dr Heather Parker, University of Otago - Superoxide dismutase and infection with Mycobacterium tuberculosis
Dr Louisa Forbes, University of Otago - Screening for Potent Inhibitors of Myeloperoxidase
Dr Katie Douglas, University of Otago - Effect of glucocorticoid administration on brain function in PTSD
Dr Philip Bagshaw et al, Canterbury Charity Hospital - Pilot study of Unmet Need
Dr Tracy Melzer, University of Otago - MRI to predict dementia in Parkinson's disease
Dr Daniel J Myall, University of Otago - Optimally predicting risk of cognitive decline in Parkinson's disease
Dr Jacqui Keenan, University of Otago - Unravelling the host innate response to enteral nutrition
Dr Suetonia Palmer, University of Otago - An evidence framework for protecting kidney function
Dr Wanting Jiao, Canterbury University - Developing new drugs for lung infections in cystic fibrosis
Dr Katie Douglas, University of Otago - Effect of glucocortocoid administration on brain function in PTSD
Dr Amy Scott-Thomas, University of Otago - Development of a non-invasive breath test for Legionnaires Disease
Dr Stephanie Bozonet, University of Otago - Regulation of endothelial cell death by Hypothiocynous acid
Dr Nicola Scott, University of Otago - Understanding how food leads to fat: the effect of dietary modification on the development of metabolic syndrome
Dr Judy McKenzie, University of Otago - Activated chronic Lymphocytic Leukaemia cells: suppressive effects on T Cell responses
Dr Carrie Innes, University of Otago, NZ Brain research Institute - Effect of obstructive sleep apnea on microsleeps and cerebral blood flow
Dr Tracy Melzer, University of Otago, NZ Brain Research Institute - Clinical tracking of cognition on Parkinson's Disease
Dr Logan Walker, University of Otago - Cytomegalovirus and Epstein Barr virus in Breast Cancer
Dr Lee Thompson, University of Otago - Role evolution and community pharmacy in Christchurch. Perceptions of pharmacists, GPs and pharmacy users
Dr Gabi Dachs, University of Otago - Chemotherapy response in obese mouse model with colorectal cancer
Dr Nadia Borlase, University of Otago - Thalmus in Parkinson's Disease ; a multimodal investigation of thalmic invovlement in cognitive impairment
Dr Judith McKenzie, University of Otago - Analysis of immunosuppression in Chronic Lymphocytic Leukaemia cells
Dr Claire Dowson, University of Otago - Cognitive / behavioural function in long term SSRI antidepressant use
Dr Leigh Ellmers, University of Otago - Effect of Chronic Urocortin2 treatment following experimental myocardial infarction
Dr Lisa Stamp, University of Otago - Effects of Frusemide on uric acid and oxypurinol in patients with gout
Dr Mark Richards, University of Otago - Renal impairment in decompensated heart failure
Dr Ruth Hughes, University of Otago - Screening for Type 2 diabetes in pregnancy
Dr Barry Palmer, University of Otago - Polymorphic variants of X-linked genes in heart disease
Dr Kenny Chitcholtan, University of Otago - Heliobacter Pylori outer membrane vescicles compromise the integrity of gastric epethelial cells
Dr Tim Woodfield, University of Otago - Alternative cartilage tissue engineering strategies; smart scaffolds and perfusion bioreactors
Dr Michael Sullivan, University of Otago - Validating biological markers for Hepatomblastoma: recovery of biomarkers (DNA and RNA) from parafin embedded tissues and development of tissue arrays
Dr Lisa Stamp, University of Otago - A Pilot Study of high dose allopurinol in the management of gout
Dr Judith McKenzie, University of Otago - Function of soluble CD83 in Chronic Lymphocytic Leukaemia
Dr Ross Kennedy, University of Otago - Determination of Effect site targets for Sevoflurane
Dr John Evans, University of Otago - Why do males die younger? Sex, steroids and yasopeptides
Dr Tim Prickett, University of Otago - NTpnoCNP as a marker of skeletal growth
Prof Margreet Vissers, University of Otago - A new role for Vitamin C in control of hypoxis response in cancer cells


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The Euro to Canadian Dollar (EUR/CAD) exchange rate softened on Thursday after oil prices rallied by 2% to regain some ground following the sharp 6% drop in prices seen earlier in the week.
The Euro to Canadian Dollar (EUR/CAD) Exchange Rate slipped to a session low of 1.3456
The 'Loonie' firmed against the Euro as it was supported by an increase in oil prices which rose as speculators continued to make bets as to when the high supply in the USA will start to ease. Despite the price rise, the value of the commodity remains bearish due to high production and modest demand.
'We are seeing little sign of economic acceleration…and anticipate a meaningful decline in oil production is still a couple of months away. Total US crude stocks continue to fly far above 5-year highs, setting new records every week,' said an analyst.
Also supporting the Canadian Dollar was data, which showed that the nation's new home price index increased unexpectedly in February. According to the report published by Statistics Canada, new house prices rose 0.2% in the second month of the year. On an annual basis, prices were higher by 1.4%.
Separate data showed that the value of Canadian building permits declined in February for a second consecutive month. The value of building permits fell by -0.9% adding to the revised figure of -12.3% recorded in the preceding month.
Positive US jobless claims data also lent some support to the Canadian currency. As the USA is the nation's largest trading partner, positive data often gives support to the 'Loonie'.
The Pound Sterling to Canadian Dollar (GBP/CAD) Exchange Rate Fell to a session low of 1.8529
The Canadian Dollar also advanced strongly against the Pound after the London based Office for National Statistics (ONS) showed that the UK's trade deficit widened to £10.34 billion in February. The Bank of England also chose to leave interest rates at the record low level of 0.50%. The bank also left its monthly quantitative easing programme at £375 billion.
Greece Successfully Repays IMF Loan
Sentiment towards the 'Loonie' also received a boost as worries eased over the Greek situation eased slightly after the indebted nation successfully completed the repayment of a €450 IMF loan which was owed today.
A Greek government official simply said; "The payment has been made."


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The history of our parklands is told through the lives of unique individuals and the actions of formative groups who left behind mementos of their interaction with the land. Through photographs, papers, oral histories, and objects, stories from the past lead us to an understanding of the present. These stories allow visitors to personally connect with their parklands and encourage partnerships vital to maintaining the lands into the future.
People of the Parks: An Unfolding Tale
Lands currently within the Golden Gate National Recreation Area (GGNRA) hold centuries of history and prehistory. Born from the elements, the varied landscapes within the park were shaped by remarkable people who, either passing through or making them home, have influenced how we view park sites today.
This exhibit portrays a sampling of groups whose contributions have helped to shape the GGNRA story. The Early Peoples panel highlights the cultural foundations of the land, from indigenous peoples, through Spanish and Mexican colonization, and the influence of the United States government beginning in 1846. Our park's prominent military history is showcased through stories of its Soldiers, specifically the men for whom Tennessee Hollow was named in 1898.
As a national recreation area, an important part of the park's history is told through its Recreationists, who first flocked to the shores of San Francisco for Chutes at the Beach, the Cliff House, and Sutro Baths, and who continue to visit in record numbers.
Finally, partnerships maintaining park resources are portrayed through the Conservationists and the Scientists, who continue to protect the land and interpret the park's cultural resources and natural environment.
Last updated: February 28, 2015


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A rather late start to the day, arriving at Hom Hill by around 11:00am. It wasn't long before we located the Great Grey Shrike at a great distance. Fortunately it let us get a bit closer.
(c) Lee Fuller. Great Grey Shrike taken beyond Holm Hill in the middle of a bog. Lovely!
After, we visited another site in the New Forest, which I'll keep undisclosed for potential breeding purposes. Here we located Crossbill with ease. Mick and Lee found a Goshawk by the car park, while I was listening to second individual calling further along the beaten track.We finished the day at Blackwater Arboretum. Lee managed to locate a Lesser Spotted Woodpecker (jammy) while Mick and I heard it call a few times. About 10 Hawfinch came into roost as did plenty of Brambling, Chaffinch and Siskin.


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VindoShop is a solution that opens up with the vision of changing how people shop in India offline. It aims to bring a radical change in the shopping psychology of the people by instilling the opportunity of getting their desired product at discounted prices. In today's time, it is widely assumed that shopping at a retail outlet is far expensive than online. We believe that a user doesn't always need to buy products from a store at "MAXIMUM RETAIL PRICE". Vindoshop will be your shopping buddy. It is your perfect shopping partner which comes fully equipped to tell a user which is the most cost efficient place to shop in the entire city for a particular category of product like apparel, shoes, bags, cosmetics, etc. Discounted prices is just one of the picks but we are much more than that when it comes to getting you your desired product with the convenience in place.When Industry stats say 88% of Indian retail is unorganized, for Retailers, VindoShop provides complete End to End IT infrastructure to bring the Unorganized into Organized and by providing better Branding, Digital Marketing and increased consumer reach. Retail market in India is to reach USD 866 billion by 2016 from 2012 USD 516 billion. There are over 12 million mom-and-pop retail stores in India thus showcasing the growth potential in the segment.Our solution will be a mixture of both B2B and B2C. For retailers, we shall be the new medium for pushing sales, brand promotion, advertisements, publicity, IT infrastructure and awareness. For customers, we will be the one app which every person would open before stepping out of their house to shop. The current segments of the retail industry we cater to are apparel, footwear and accessories."In a nutshell, VindoShop is an Omni-channel Retail Solution catered just for you"
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text: So, for the past 4 years I've been designing hand drawn cards for a local flower shop. When I first stared they were all 100% done by hand…then demand went up and it was hard to supply them. So I started working more digital and getting the cards printed. This save me time and allowed me to sleep. At first I was dead set against this but I just couldn't keep up. Working with Ps and Ai has actually help me keep the creativity flowing. Now I am working on having a bank of cards to chose from and hopefully I will be able to get more business. Here is one of my new designs.


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Our platform provides a solution for teams that are spread too thin, need a better way to match students with alumni, and are looking for a way to create a smart directory of their alumni base. You can use our platform to do reporting and provide a tangible example to the work you're doing. Wisr's platform allows for schools to engage and report more efficiently than before, no matter what size your school is.
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Barry Minkow is a nation unto himself. This guy is an incorrigible trickster. There are no murky schemes he has not dipped into. However he has fooled everybody for so extended due to endorsement of media. They developed him up first as a wonder boy and later when his kingdom of falsehood crumbled and he went to jail, they had been once again taken in by his crocodile tears of repentance and accepted his new avatar of fraud buster, publish his jail term.
JoAnn Trujillo of Dat's Italian in Previous Colorado City at 2514 West Colorado Avenue answered, "Daily. Typically in the early am. But often so considerably to do can't often reply to them for hrs or days" Check them out for great, inexpensive Italian Meals. Need much more info? Call (719) 632-3287.
If you are searching for a cleansing Guildford, you will uncover a amount of choices that you would be rather puzzled in generating a decision. Presently these cleansing organizations are increasing day by day on account of the improve in the scope of the interiors decorations. Men and women commit a good deal of funds on the interiors of their houses so that their house looks the very best. There has been a competition among the folks to have an edge above others. Carpets have been regarded as a crucial element the place great artistic patterns can add to the attractiveness of the floors.
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I have worked as a carpet cleaning technician in Rochester, New York for the past 6 years and definitely swear by the Dry Foam Extraction cleansing method. Knowledge has taught me that it is far superior to the steam cleansing strategy. It is a very powerful reduced moisture and speedy drying https://www.americasfloorsource.com/products/carpet/ strategy. The Von Schrader Business in Racine, Wisconsin manufactures the equipment. They've been in enterprise because 1935.
Irrespective of the dust and dirt accumulated carpets need to be cleaned at least as soon as in a yr. This can make sure that the dress in and tear of the carpet is reduced and the age of the carpet is extended. Choose a specialist Business to get the very best outcomes. A contractor who is effectively adept in most recent cleansing technologies can prove to be far much more powerful when compared to those who sub contract the work. Typical training and upgradation can prove beneficial in the cleansing industry. With small research and reference it is straightforward to connect with the appropriate organization.
Paint/Candle Wax – These are considerably easier to get rid of then you could think. If you have WD40 about, spray the location generously and merely pick the pait or wax off. If not, you can use ice cubes. Just consider the ice and rub the location until the spot freezes above. Soon after a handful of seconds you will be in a position to get started peeling it away. Continue these measures until pleased. If there is color left above, combine one element of a mild detergent with one element baking soda and 2 components scorching water. Scrub the color until gone.
It's likely that your carpet cleaner will either charge by room or by square feet. Few but some could charge by yards or another measurement. Either way, it could adjust when the cleansing is total or after the cleaner arrives. That's why it's crucial to have a quote as an alternative of asking about cost above the phone. You could uncover it straightforward to add a handful of numbers when becoming charged by the location or room but it's not often that straightforward and like I explained, cost could adjust after an actual evaluation. Most carpet cleaners will give you a free in house quote.
If a specialist carpet cleansing is an option, I suggest it. Carpet cleaners are qualified to get rid of spots and bacterias. If not, follow these measures and good luck!


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Revlon Super Lustrous Lip Gloss
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Justin Rose claims world No1 ranking at BMW Championship ahead of Ryder Cup
Justin Rose played his way to becoming world No 1 at the BMW Championship
JUSTIN ROSE is the new World No 1 despite losing a play-off to Keegan Bradley at the rain-extended BMW Championship last night after knocking Dustin Johnson off the top of the rankings.
The 37-year-old Englishman missed from four feet at the first extra hole at a sodden Aronimink allowing Bradley to tap in for the par that handed him victory. But while the American won the battle; it was Rose who won the war.
His journey to the top has been far from straightforward. He famously missed 21 successive cuts after turning professional. But as a Major champion, Olympic champion and now World No 1 it has turned into the complete career.
He is just the 22nd man to reach World No 1 since the system was introduced 32 years ago and the fourth Englishman after Sir Nick Faldo, Lee Westwood and Luke Donald.
"It's absolutely unbelievable. They are all heroes, all great guys, all role models. It's scary company really because they are all absolutely incredible players," said Rose.
"It's boyhood dream stuff. When I talk about my career, I now have another string to the bow and World No 1 would be right there with the other achievements.
"It's something I'm incredibly proud of. It has been a good stretch of golf for over a year. I always envisioned myself getting to world No 1 by winning tournaments and I haven't won – it kind of takes a slight bit of the edge off – but I'm delighted to have got to the top."
What has propelled Rose to the top? Ironically, given the one that got away on the 73rd hole, it is his putting. This year his numbers contrast sharply with previous seasons – he is in the top 15 on the PGA Tour – which has allowed him to capitalise on his always imperious work tee to green.
His all-round consistency has been extraordinary. He has finished in the top 10 in 20 of his last 27 tournaments.
Justin Rose lost narrowly to Keegan Bradley in a play-off at the BMW Championship
The full package has come relatively late – he is the third oldest to top the world rankings – but 20 years after alerting the world to his talent with a fourth place at The Open as an amateur this latest achievement underlined how he has delivered on that rich early promise.
There will be few more popular figures to have reached the summit of the world game. Rose is a gentleman dueller in golf's finest traditions and the same likeable man away from the course.
The runner-up finish that took him there followed a dramatic Russian doll of a closing round where the story inside the story was the main event.
A cluttered leaderboard meant there was still plenty of traffic in Rose's wing mirror when he knocked in a six-foot birdie at the 12th to take the outright lead.
Justin Rose will be a key element of Europe's Ryder Cup team in Paris
Billy Horschel and Keegan Bradley were quick to join him with birdies at the short 14th and Xander Schauffele was also lurking.
Back-to-back to birdies from Bradley at the 16th and 17th took him two clear but Rose followed suit magnificently.
When the 2011 USPGA champion unravelled at the last, bogeying it to finish 20 under, it opened the door for Rose. He was unable to take advantage as he left his four-iron approach short of the green and botched the pitch too leaving himself a 15ft par putt which lipped out.
The contest headed into extra time but with Horschel out of the game and Schauffele unable to convert for birdie from 25 feet at the last, the solo second spot Rose needed for World No 1 was secure.
Rose hooked his tee shot at the 73rd hole in the rough and then bounced his second off the grandstand on to the apron around the green. Bradley, more conventionally, landed in similar territory.
Rose was unable to get up and down; Bradley managed it but second best on the day was sufficient to become the world's best overall.


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A few pictures...see video at the link above
The story behind the Castle of Horror Heights..........there is a insane Billionaire who built this ride. You'll see him throughout. He's the one with the blue hair. He's always with his girlfriend and pirate bodyguard. He imprisoned some of your park guests and workers to put throughout his ride. They are leld mostly on the main floor where the guests go up the stairs to get onto the ride. Everything at the beginning of the ride gives the appearance that the ride is Fairy-tale like but it's not as you will see throughout the rest of the ride. Behind closed doors he's an evil man.
On what I call the bridge, you'll see the billionaire who has zombies and mummy's imprisoned. He tries to electrocute you with lightning (all timed) He doesn't succeed.
When the doors open you will see different scenes on the different floors. Loaded with animitronics.
Bottom Floor: Zombie Studio Animitronics are on 2 balconies trying to escape fires. Blue haired billionaire watches on.
2nd floor: Takes place in his Study. The billionaire, his girlfriend and bodyguard are there too. Lots of Spooky DLC animitronics..
3rd floor: Archaeologists hard at work digging for skeletons in rubble.
4th floor:Graveyard under the stars. Mummy and Zombie's attack the billionaire as an act of revenge for all he's done. He wanted to dig up more skeletons to use in his ride. I added star panels for the walls and the sky so it really looks like your outside. Added trees, flowers for realism. Skeleton animitronics, fog and more.
5th floor: The billionaire is burning the evidence of his torture and imprisonment of guests and so on. He's burning boxes in the fireplace. Takes place in his living room. Lots of straw exploding out of the fireplace, lots of fire embers so it looks like the boxes are actually burning up. Mummy animitronics and more.
6th floor: The 3 of them try to escape in his helicopter.
I added the Time machine sequencer and set it to last the length of the ride but it only last 20 sec. I tried adding multiple ones but it didn't work. So just make it dark when you ride it. It looks good either way.
It's located just to the left of the exit gate.
YOU ONLY HAVE TO LOWER IT A TINY BIT. 4 meters or so.


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Mother Nature's Winter Surprise
In Washington, D.C., the streets are slush-covered around Capitol Hill, but there was quite a different picture Tuesday, reports CBS News Correspondent Bob Orr.
Area weather forecasters had said to expect only a light snow, in some cases just a dusting.
But the snow started earlier than the meteorologists predicted. It continued all day long and into the evening. By the time the snow quit late Tuesday, 6 to 12 inches of snow had fallen around the D.C. area.
The amount of snow that fell was twice the combined total for the past two years.
Government workers were sent home early Tuesday. On Capitol Hill, the Senate closed up shop, and the House canceled roll-call votes.
"The weather isn't a perfectly predictable thing," said Meteorologist Doug Hill of CBS affiliate WUSA-TV in Washington. "You can't predict every single storm every single time the right way."
This monster storm was born in the Midwest. It covered a 1,000-mile swath from the Great Lakes to the Eastern Seaboard.
The deepest reported snow was 14 inches in Minnesota, making it that state's biggest snowfall of this winter's season.
The storm is even more memorable for one Minnesota couple, whose second child was born during the heavy snow, reports Frederica Freyberg of CBS Station WCCO.
Police helped plow the snow in the street so an ambulance could rush the couple to the hospital in time for the birth of their child.
Meanwhile, hundreds of flights were canceled around the country. More than 600 planes were held up at Chicago's busy O'Hare airport Tuesday because of nearly 10 inches of snow in the area.
Flights are delayed again Wednesday, but they will tend to get back to normal over time.
The warmer southern part of the storm caused the most damage, particularly in the form of tornadoes and thunderstorms, reports CBS This Morning Meteorologist Craig Allen.
The storm brought down trees in Memphis and ripped the roof off a house in Oklahoma.
Countless schools were closed. Accidents and nervous drivers clogged highways, and air travel snafus were the norm.


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Monday, 7 December 2009
(Harold Bloom)
Thoroughly enjoying Harold Bloom's Omens of Millennium: the great literary critic is so much more enjoyable when not doing his tired 'Ain't it awful?' number, that is, when not writing about literature.
The book has his usual faults: it reads as though Bloom actually wrote a 50,000 word long essay and then left his put-upon research assistants to pad it out to book length. It is full of repetetion, often telling us the same thing twice in the course of five pages: that Elijah became the angel Sandalphon, for example, or that when the next 'authentic' American prophet comes to follow Joseph Smith, 'we will not recognise her (at least at first).' It has Bloom's bad habit of adding '-ism' to words to create unclear abstract nouns---'angelicism', for example----or using technical terms in non-technical ways; Nietzsche's 'perspectivism' is pressed into service to mean something like 'a vertiginous evocation of soaring height and plunging depth', and 'vitalism' is used to mean 'irrepressable vitality'. It has irritating tics like his dislike of Jung's thought ('a reductive cult'), which he clearly doesn't understand at all, and his ironic fondness for Mormonism. There is a strange sequence of pages in Chapter II ('DREAMS') in which the prose suddenly ceases to make sense, Bloom going incomprehensibly off on one for about 3,000 words. As I read it, I assumed I was failing to understand a word because I was drunk, before realising that I was, in fact, perfectly sober.
For all that, it's an enjoyable book, if you like delving into Kabbala, Sufism, Swedenborg and the like; full of incidental hermetic joys, its main interest for me was in listening to Bloom telling us a little about himself and his own ironic, neo-Gnostic religious sense, rather than talking his usual old bollocks about 'self-overhearing' in Shakespeare.
Labels: Books, Literature, Religion
2 comments:
- Yewtree said...
Talking of Kabbalah, Sufism, etc, you've been tagged in the "Interesting Religions" meme.
- 8 December 2009 at 20:37
- Jane Holland said...
Love that you feared you were drunk but were in fact sober.
I miss being stoned.
- 12 December 2009 at 14:28
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