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*For years, I have been filled with anxiety, as I watched explosion of the "cottage industry" of herbalists; naturopaths; "holistic" doctors; and the like. Now, some of will quickly point out that I, too, was once mostly known for my contribution to this growing population. But, like any good sinner, I have repented, and vowed to sin no more. (Thank you, Dr. Edward S. Cooper!)
Let me explain, over thirty years ago, after being a Pre-Med student, I made a decision not to go on to medical school, and direct my interests and talents to supporting the ability of people to take better control of their own lives and their health. This led me down a long path (that included years of working with Dick Gregory), and ultimately to being, what some consider an important voice in health advocacy and health education.
Included in my journey were "stops" as an herbalist; homeopath' Health Store Owner; health columnist and lecturer; and a media commentator.
The most disturbing part of these experiences, as a "sinner", was the speed at which people were prepared to do, or take, whatever I suggested for them to take to "cure what ails them". Never mind that they were under the care of a medical doctor for serious medical conditions.
The resulting effect on me was to do two things: 1) do everything I could to make sure that anything I said or wrote was based on as much scientific and/or researched information as possible. I read and study as much as any medical doctor or scientist. 2) I strongly adhere to the premise that there is no "alternative" to a medical doctor. This has led me to be a strong proponent of Complementary and Alternative Medicine (CAM). What it means is that I don't do, say, or suggest anything to anyone without the knowledge and/or approval of their medical doctor.
I shudder when I hear of people who brag about ignoring their doctors' recommendations because either "they don't believe in Doctors' medicine", or because "an herbalist looked into their eyes" and said that they had just the thing for their medical condition.
I recently heard a story about a tragic example of how wrong these types of decisions can go, and how costly (in terms of life and permanent risk to health).
For years, I have not written or spoke publicly on my disdain for what I consider to be charlatan (somebody who falsely claims to have special skill or expertise) behavior in the name of "healing' people learn the natural way. But as these incidents continue to happen more and more, and families are devastated by the senseless loss or injury of a loved one, I am silent no more. I have to live with my own conscience. I have been given the privilege of being a source of trusted and valued information, and so add this to the growing list of topic I will write about.
The use of dietary supplements has risen tremendously in recent years. Increasingly, people now take herbs and other "natural" substances in addition to vitamins and minerals. These so-called nutritional products are not as strictly regulated under the law as prescription drugs, however, and to use them wisely, consumers should know about the risks and benefits associated with supplements. Dietary supplements are billed as immune triggers, weight-loss wonders, "brain power", muscle-expanding elixirs, and much more. They can be bought from the shelves of health food stores, drug stores, and supermarkets. They are a category of nutritional additives that once included just vitamins and minerals, but now also encompass herbs, amino acids, fish oils, hormones, and many other substances. Not only is the array of supplements dazzling, but also their popularity is soaring.
Sales of vitamins and minerals in America alone have reached $25 billion annually! And with the USA accounting for barely 5% of the world's population, we buy over 30% of all of these supplements. The reason for this is partly as a result of rising medical costs which encourages both prevention and self-care. Like many things, African Americans, and other underserved communities, are impacted disproportionately, and turn to these "alternatives" in larger relative numbers.
Even science has lent credibility to a handful of the claims made for dietary supplements. Some studies have suggested, for example, that vitamins may help prevent serious illnesses such as heart disease and cancer. All this has fed a media frenzy regarding the latest research into natural remedies. We see Madison Avenue using people, places and things we care about to appeal to our emotions, just as would in selling us cars and "happy meals". I was shocked (even though I shouldn't have been) to hear a prominent national civil rights leader as a spokesperson for a "new" herbal product for men's prostate conditions.
At the same time, supplements of all kinds have moved from niche retailers such as health food stores into drugstores and supermarkets, making them more widely available and also more appealing to the mainstream public. And the claims have gone far beyond what science has shown, appealing to everybody from athletes to people with chronic diseases.
"True" herbalism encompasses scientific testing, honest reporting of the results, and safe use of effective herbs by informed practitioners and the public. It also includes the production and ethical marketing of herbal products. True herbalism, which brings honor to the wonder-filled world of plants, does exist as part of the science of pharmacology. However, there is a dark side to herbalism.
Herbal medicine has long been an alternative for those seeking health-related remedies without using powerful pharmaceuticals. While these herbs tend to have a lesser degree of side effects, they can still cause adverse reactions if used improperly.
Herbal medicines, like other forms of medications, can sometimes contain other additives to help preserve the pill or enhance the effect of the herb. It is important to be aware of what is in your herbal medicines, particularly if you are allergic to certain additives. This information is sometimes readily available on the bottle; at other times, you may have to do some research before beginning to ingest any herb.
For the many untested pills, capsules, powders, and liquids that remain on the shelves, it pays to be cautious. Here are a few tips for dealing with the supplement conundrum:
- Before taking a supplement, find out what evidence supports its advertised benefits-and dangers.
- It is a good idea to glean information from a variety of sources, not just one book or magazine article.
- Learn what "real" scientists know about safe dosages and do not exceed them.
Somewhere, as you read this column, there is someone either dead or suffering from not having the benefit of this information.
Everyone knows consumers buy supplements to prevent or treat what ails them in order to escape the sometimes adverse, allergic, or dizzying side effects they've had from prescription drugs. The reason people buy supplements is to have a better quality of life. Consumers also want a safer quality of supplements and foods. People buy supplements also out of fear.
The real questions are not whether the supplements make you healthier, but are they safe? Are you sure that the person "prescribing" seems to know what they're talking about, but are they really trained in helping you or are you just a good customer? How do these people become a "Doctors" anyway?
Remember, I'm not a doctor. I just sound like one.
Take care of yourself, and live the best life possible!
Glenn Ellis lectures and is an active media contributor nationally and internationally on health related topics, including health education and health promotion.
For more good health information, visit: www.glennellis.com


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Standard Orders ship by 03/08/FRI
Rush Orders ship by 03/01/FRI
from your personal experiences
We love receiving new sand or other natural elements, and are happy to create a custom piece of jewelry from your own personal experiences. Each piece of jewelry uses just a pinch of sand or elements. You know all that sand that sticks to your flip flops at the beach? Yep, that's enough to create a piece of Dune Jewelry! Send about a teaspoon of sand for every piece you would like to order.
Dried flower petals, crushed stones, and other materials can be incorporated as well, and we still use about a teaspoon for each piece. If you send a ½ cup or more, it will be added to our growing Sandbank™. If you have a question on how your natural element can be incorporated in our patented process, please feel free to email email@example.com.
When selecting your pieces, you will be prompted to select "send your own sand or element". There, you will provide some basic information about the sand or element you are sending; then you'll complete the Sand & Elements Submittal Form so we can pair your sent-in sand or elements with your online order. Below are some tips for processing your sand/elements. Please reach out with any questions to firstname.lastname@example.com.
Please adhere to all local, state and national regulations when sand or element collecting. It's VERY important that you don't remove any sand, rock, soil, shells or other elements from ANY of our protected beaches within the National Parks, Seashores or sand from Hawaii. We do not create jewelry or accessories with any illegal sand/elements.
We want to capture memories near and far, however, if you are sending sand from outside the United States there are a few rules we ask you to follow.
All excess sand sent/delivered to Dune Jewelry shall remain the sole property of Dune Jewelry Inc. unless otherwise instructed.
We happily create jewelry every day to capture your most cherished memories so that you have a tangible reminder to wear always.

subset: commoncrawl


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Playa del Amor or 'Lover's Beach' is safely tucked away behind Cab San Lucas' most striking natural icon, El Arco (The Arch). The beach curves around the coast, with its 'sister beach' often referred to as Playa Divorcio (Divorce Beach), due to its uneasy waters.
The beach is incredibly picturesque, with sun-baked sand and clear blue-green water. As it's only accessible via water (though this isn't a difficult task given the water taxis and tour boats that frequent the Cabo San Lucas marina), Playa del Amor has earned a reputation for romance.
The beach has become quite the tourist attraction but is still very much worth visiting for its stunning natural beauty. It has been named one of the ten best beaches in Mexico.
Swimming and snorkelling are popular around the calm waters of Playa del Amor, especially as Playa Divorcio on the opposite side of El Arco is notorious for strong currents. Stick to the Sea of Cortez side of Playa del Amor if you want to hop into the water. Playa Divorcio is still perfectly fine for sunning, though, and is a short stroll from Playa del Amor along the sand.
If you do choose to don a snorkel mask, keep an eye out for schools of colourful tropical fish. Also keep your eyes peeled for sea lions who like to hang out on the rocks below The Arch.
The journey from Cabo San Lucas marina to Playa del Amor takes all of five minutes via water taxi, or you can choose the half-hour scenic route on a glass-bottom boat tour. You can jump off the boat straight into the water!
Check the weather on the day of your trip as you may not be able to exit the boat onto the beach if waves are too high. It's also recommended to pack some snacks and water, as there are no vendors on site.


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Tiffany dome at Chicago Cultural Center.
Photo by Pauline.
Pauline G. Dembicki
Hello, I'm Pauline G. Dembicki, I've been practicing law for over thirty years and have learned about four things.
One, while I do crisis management, I encourage you to plan as soon as you realize the value it holds.
Two, planning give you time to weigh the choices and to interview your potential administrators.
Three, the term legal advice is often misunderstood.
Four, lawyers talk funny, in our own language, understood only by other lawyers.
You can call me at 847-650-6850, weekdays, bankers hours.
My email is firstname.lastname@example.com


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Adjusting the bridge a bit after we bought some salmon from the Native Americans who can fish freely.
Hope to catch up soon:)
The post I've been waiting for all week! Doesn't it look like the Lake District? That picture of you and Cristi on the bridge reminds me of us posing in Ambleside before we had chips!
Love your pretty green dress and cristi's cat skirt, you sure managed to cheer up that grey day, didn't you?
I bet that salmon was wonderful. I love Kettle Chips (salt & vinegar!)
Speak soon! Love you! xxxxxxx
I adore that first photo of you and Cristi, and the Meaning of Life shot on the bridge! What a beautiful spot, and you two ladies only make it even more lovely! The print of Cristi's skirt is so sweet, and I love your green dream of a frock.
The water looks amazingly clear, and the fish look good, both swimming and fried (sorry to all vegetarians!)
Mmm, Kettle Chips...
Blogger has been OK for me, apart from doing weird things with the font size when I type a post - what's that all about?! xxxx
I'd like the jalepeno chippies, thanks!!!
I had no idea this was an event, man those fish are gorgeous!!! Do they go nuts and leap about and stuff? I most certainly like eating the little feckers!
SO beautiful there, I love what little I saw of Oregon, and can't wait to get my arse back there! It's not disimilar to parts of New Zealand.....you'd love it here!
Love you! XXXXXXXXXXXXXXXXXXXXXXX
What an excellent trip.
There is no meaning.
But I love those huge fish, the nature, and the wildlife, I mean you and Cristi on the bridge. I wonder if you change colours according to the seasons... I imagine hikers would find not antlers but awesome leggings wrapped around trees.
Thanks for sharing! It's was soooo delicious!
Beautiful, beautiful, beautiful
Beautiful views, outfits and yummy looking fish! What more can you ask for eh :)love your green dress and that loverly cat skirt :)
This looks like a fun trip! I love the kitty skirt and that salmon looks so delicious:)
Yay what a very cool thing to go and watch sweet......especially you two fabulous ladies looking amazing as always.
Yummy looking to.........oh growling tummy.
Have a wonderful weekend.
Love V
love it!! fist pumps, fishing, contemplation, awesome outfits, yum food and gorgeous views too, so fab! Mr F has a kettle chip addiction I swear he would pass out if he saw the maple bacon flavour! x x
Luckily my kids have had much learning (hands on) and field studies regarding our NW salmon. Glad you got out to see them too. I find salmon too rich for my taste (sacreligious I know our here) but my hubby loves it.
Hi Krista,
Just read your comment on Curtise's blog and wanted to say how much it resonated with me. I think I have some idea of how you're feeling right now as I went through it with my mum two years ago. Don't want to say too much in a comment and can't find your email address but just to say I will be thinking of you and your Dad.
I'm not what you'd call an "outdoorsy" girl, but days like this are lovely; good company,the water, trees, and watching something that has taken place for years, and hopefully will for years to come. I love grilled salmon (sorry fishies..) and salt and vinegar kettle chips.
How gorgeous is the scenery--and made even more fabulous by you and Cristi--your green dress is adorable!!
OMG--Maple BACON potato chips????
I NEED these!!
You can't beat nature, it wins hands down every time. Bet it was amazing to see that spectacle. I'm glad the native Americans are able to fish freely and sell their produce, that's good.
Hi Gene! :) I have a friend called Noon and we like to say Hi Noon to her.
You pair sure are rocking those outfits! :) No breathable anoraks in sight! xxxx
I love the photos. I especially love how your colorful outfit says, "screw you autumn! I will not mute my colors!" you're beyond awesome.
Nature! it's the best
Love your outfits girls!
That kitty skirt is so great, did she made it?
About those chips, yes i know! so good - the combination of sweet and spicy is so addictive...
Blogger is fine for me, too bad you had problems -
Ariane xo
Your both outfits are fantastic and i love your cute hat! Guess the salmon tasted divine, oh i love fish and rice! Discovering new activities near your town is always exciting isn't it? xx Tani
Oh man - I would LOVE to see the salmon! That countryside is just gorgeous and how have I not noticed your fabulous glasses before? Or am I just so far behind???


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This post is a little late coming, but better late than never! Almost a month ago I had a great weekend of music in Toronto catching Yuck's show at the Horseshoe on Sunday evening, and tUnE-yArDs the night after at Lee's Palace. tUnE-yArDs (who's name is a real pain to type…) were fantastic, Yuck on the other hand left me a little dissapointed. They also had some of the worst stage banter I have ever seen, they managed to get Toronto confused with Montreal, then in an attempt to recover they managed to offend every French Canadian in the audience, and just generally make the crowd collectively cringe everytime that little gap between songs arrived.
The saving grace of that show for me though was the openers, Toronto three-piece Rival Boys. I always love it when I discover a new band I like as an opener, and this was one of those situations. I went back a week later to see their own show at the Supermarket in Kensington Markets and this time remembered to bring my recording equipment so I could get the following videos (watch them in HD):
Live video playlist
Rival Boys at times reminded me of some of my favourite Australian bands, in the slower violin based songs it brought to mind the briefly lived Sydney four-piece Charge Group. In the more rocking songs I was left thinking of The Jezabels. Their opening song Movement (also the tracks on their recently released record Mutual Feelings of Love) does a pretty good job of summing them up what you're in for. It starts with a thumping four four bass drum and palm muted guitar and soft sung sorrowful lyrics which build into the explosion of growling vocals and guitar.
Their upbeat instrumentation manages to keep you tapping your feet even though the melancholy subject matter. But it's not all driving indie rock. In their slowly moments, such as their album closer Dream of Stones, the bother-siter harmonies and delicate guitar and violin is just as effective as their faster numbers. For a three piece they do pretty good job of filling out their sound, but I would love to see them recuit a fouth member from somewhere so they could have bass and violin in every song. Overall Rival Boys are a young band worth keeping an eye on.
Flickr photograllery
On a side note — Supermarket has some crazy trolley decoration, such as this, which I took as a shout out for a friends blog Trolley Kingdom.


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The Stride Short Sleeve Crew for men has a lightweight, breathable Vapourlite fabric, with grid mesh panelling on the upper back for added ventilation. While the crew helps absorb moisture from the skin it's also seamless to prevent unnecessary friction and maintain comfort. Ronhill have created an excellent training top which is so versatile you'll probably have three of them; One in the washer, one in your kit bag and one on your back.
- Fabric:
- Main: Vapourlite (94% polyester, 6% elastane)
- Mesh: 100% polyester
- Breathable
- Moisture wicking
- Flat lock seams
- Grid mesh panelling for added ventilation
- Reflective detailing
- Weight: 114g
Ronhill are named after Dr Ron Hill MBE - Accrington lad, scientist, world record breaker and runner. But not just any runner; Ron was a serious runner. And when you're clocking the kind of mileage he was (in excess of 100 miles a week) you start to notice where your gear is letting you down - and for Ron it was clothing.
In the 1960s there was nothing. Just cotton shorts that weighed a tonne when wet. No waterproofs, no lightweight shoes, no vents. So Ron took matter into his own hands and founded Ronhill. Drawing on years of experience, Ron pioneered simple but revolutionary new innovations in sports apparel – like the shorts with a side split and the development of new, moisture wicking textiles. Today's industry standards in performance apparel were Ronhill world firsts. And that's why they're more than just a sports fashion brand; they're a running institution.
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I've never claimed to have all the answers
i've never claimed to have all the answers
We are just hearing his version of the whole situation and obviously he will play the victim roll to protect his ass. Trayvon or any civilian would feel threatened and react to being attacked without warrant. Remember Zimmerman was told by the Dept to not pursue the person but, he was defiant and still did.
As a physical therapy job is in much demand, and is extremely well paying, it is a popular career choice for many. To become a qualified physical therapist, one needs to have an excellent educational track record in undergraduate programs. Undergraduate programs must include anatomy, medical assisting, trigonometry, computer skills, humanities, geometry, chemistry, physiology, and/or health education in order to seek admission in a physical therapy graduate program.
But once you step up your training and start pushing yourself to go faster and farther, you can forget about all your cute nail polishes and go ahead and burn your flip flops. You're never wearing them again. Your feet are going to become gnarled, calloused, toenail free hooves..
And there are frequently people who speak in meetings and identify themselves as Roman Catholics, or as followers of Jesus Christ, or as members of various Christian churches. Is not a Christian Fellowship. Includes members of many denominations Roman Catholic, Jewish, Buddhist, and humanist.
To sum it up, paper is being utilized more and more but fewer trees. Beasts use trees as a natural home ground and they are essential for the wellbeing of the environment. There are plenty of choices for us to recycle paper and to ensure that books and magazines are reused instead of thrown away..
To their defense,because of the lighting and what I was wearing,it was quite hard to see the belly when looking at me straight on. As a married,soon to be mom,it was wonderful,getting looks from cute guys (especially knowing that I didn have to deal with the whole dating thing). Thankfully,my husband also found it entertaining..
I decided to do my own real world realistic calculations based on this strategy. The calculation is based on my own computations using real market data. I included dividends, dividend reinvestment,That makes me feel great, plus trading and spread fees. Ok people lets not be BIG A HOLES here so people may be a bit uneducated about the matter but now they are informed. We are all learning new things each day. To be so rude to people who don understand the regulations is plain nasty.
Ground blizzards are created by snow being swept off the ground by strong winds. It is known as a Nor'easter, owing to the north easterly winds that direct it inland. These storms cause blizzard like conditions, coastal flooding and drive hurricane force winds..
A portal into Manaus' historical past, the Museum of Seringal Vila Paraiso captures the plantation era of the region's rubber boom in the 1800s and its industrial past. The museum tour begins with a boat ride to visit a chapel once used by workers for worship. The tour then takes visitors to an old manioc factory where workers once toiled to produce manioc flour by hand.
Hard disk space, processor and RAM are computer specifications that are often argued about, but the most expensive peripheral of a computer is its monitor. A slim, sleek profile makes it a space saver on a desk. Minimal wiring and quick connectivity to multiple devices just add to its appeal.
Highlight the track name of the tracks you wish to control. Option+Shift+(Mac) or Alt+Shift+(Windows) the insert, bus,Giving us a 10 year old John Connor who, or other function you wish to alter or add on one of the tracks. All of the tracks will complete the action.. It is the medical term for an infection of the middle ear. Otitis media is the most common type of ear infection, that is usually associated with a buildup of fluid in the middle ear. The Eustachian tube connects the middle ear to the throat, and is responsible for draining fluid from the middle ear.
Fridays Live in Chicago Madonna and Kelly Ripa:Mark and his wife Kelly Ripa went to the Madonna concert last week at Madison Square Garden in New York City. Mark joked that the only reason a man goes to that kind of concert with his wife, or the Oprah Show for that matter, is because he is going to get lucky afterwards. Mark and Kelly were front row center at the concert enjoying themselves while Madonna and Pharell put on a great show.
Monkeys are known to put a strain on family as they have their favorites. They are known to get their water intake mainly from the food they eat, and from puddles and tree holes. They also eat small birds,500 that he couldn stop taking amphetamines for a month, tree frogs, spiders etc. (and that gameplay and aesthetics are more important which I agree but.) A few months earlier at a gaming convention he said when game reps were touting 1080/60 you want a fucking gold star "We buying these new consoles,they better be running at 60 frames per second at 1080p".Part of it might be he is talking to a crowd but when he is scoffing at game reps proud they got 1080/60 that he expects of them it feels like he is calling them out! That he has a standard to be met for next gen. Which just makes him look silly when he downplays it and tries to be the voice of reason, especially when speaking to those to those making a big deal of the resolution as a part of the console war and fanboyisms.Saying I think chemical weapons dealers have a more tolerable consumer base than videogames. I am truly embarrassed for this industry.Well I am not in that list am I? I try to be reasonable.
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It's been a more eventful week in IT land than I expected. First, Microsoft announced yesterday that the next versions of Office for Windows and Mac OS X will use ZIP-compressed XML file formats as the default. Woohoo! No more brittle binary files. And they're being smart enough to change the extensions so you can easily distinguish "legacy" Office documents from the new XML-based ones.
But then CNET News.com dropped a real bombshell when it reported earlier today that Apple will announce on Monday that it is switching its Macs to Intel. I'll believe it when I hear it from Steve Jobs' mouth. But if it's true, that means that Apple switches to Intel at the same time Microsoft moves Xbox to IBM PowerPC. What???


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Spun Bond - PP Non-Woven
GUJARAT MACHINERY PVT LTD is a Fast growing trend setting company catering to the needs of the plastic PP / HDPE Woven Sack, BOPP / Polyester / Alluminum Foil / Paper Lamination, Jumbo bag / FIBC Fabric & Trapaulin Manufacturing Industry.
Gujarat Machinery Pvt Ltd Specialises is setting up complete Trunkey Projects custom made to suit the specific requirements of its customers.
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text: I used PwnageTool (I think, might have been QuickPwn ) to get the custom firmware for my iPhone (iPhone1,2_2.2_5G77_Custom_Restore.ipsw) and now I'm not sure what to do. Probably easy question but I am confused as to how to put the firmware on my iPhone. Also, another quick question: When it is on my iPhone, and I go to restore, when it verifies the software will everything be fine? Thanks guys. Sorry if they are easy questions, I just want to know as I don't want to stuff this up epically!


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What Every Cruise Ship Passenger Should Do Before Taking a Shore Excursion on a Cruise Ship
Cruise ships market many shore excursions for the exotic ports they take the passengers to. Shore excursions present potential risk of danger, and before booking a shore side excursion, a cruise ship passenger should do some research about the particular excursion and not rely upon the cruise ship companies representations.
It would be well advised for any passengers to at a minimum do the following:
- Go on the computer and google the name of the shore excursion and the company, and see if you can get any information about the company, or information from prior passengers who participated in the shore side excursion.
Often times you will find out from prior cruise ship passengers the dangers of the shore excursion that the cruise ship company failed to warn about. Also try to gain information about the local port excursion company to determine if the company is licensed, insured, and whether it has a reputation for maintaining up-to-date equipment, and trained employees. If you are unable to get this information from the website, supplement this information by asking these types of questions to the cruise ship employees onboard before purchasing a shore excursion.
- If the cruise line makes representations about the reliability and safety of the particular shore excursion company, suggesting that they have vetted the operation and determined it to be reliable and safe, confirm this with representatives of the cruise ship company.
It is important to try to gain as much knowledge as you can as to what knowledge the cruise ship company actually has regarding the shore side excursion and the operator.
- Ask the cruise ship company representatives to explain the disclaimers about the shore excursions, where the cruise ship companies disclaim any liability for negligence of the shore side excursion operators by claiming they are independent contractors for which the cruise ship companies assume no liability.
Ask specifically what will happen if there is an injury, how will you get appropriate medical care and treatment, who will be responsible for the medical care and treatment, and who will assume any liability for negligence associated with the shore excursion company.
The above are some simple steps you can take. Of course, it is hard to determine the reliability and safety of shore excursions in foreign ports you have never been to. The cruise ship companies should have much superior knowledge as to the reliability and safety of these excursions and companies. Although the cruise ship companies attempt to distance themselves from these excursions, despite recommending them and profiting from their sales, do your best to gain as much information as possible. If something does not feel right, do not go forward with the excursion, and if you get to a shore side excursion and feel in any way there are safety issues present, do not go forward with the excursion. Cancel immediately, and demand a refund from the cruise ship company.
If you do suffer an injury during a shore excursion, despite the disclaimers of liability the cruise ship companies put in their passenger tickets and the shore side excursion tickets, you may be able to pursue legal remedies against the cruise ship company. You should contact an experienced maritime lawyer to evaluate your rights should you suffer harm during a shore excursion.Related Pages:


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The 72nd session of the United Nations General Assembly is currently underway in New York City. As expected, the North Korean nuclear aggression and the humanitarian crisis in Myanmar pertaining to Rohingya people have dominated the discussions.
Aung San Suu Kyi, Myanmar's State Counsellor who has come under fire for turning a blind eye to the plight of her nation's minority Rohingya population, is absent from the UN meeting, perhaps in an attempt to avoid embarrassment and a "public trial" by the international community.
To be fair, one can argue that despite being the de facto leader of Myanmar, there is not much that Suu Kyi can do to stop the government forces from going after the Rohingya people. Suu Kyi might be in charge of the civilian administration, but the military still calls the shots in the country.
Still, there is this question: Why didn't she at least speak out against the military's ruthless onslaught against the Rohingyas and lend her voice to end the people's misery throughout the crisis?
Well, the answer as to why she didn't so is simple. If she had spoken out in favor of the Rohingyas, she would risk angering Myanmar's Buddhist majority population who form the support base of her ruling National League for Democracy (NLD).
Conflict and tensions between the majority Buddhists and the Muslim minority, i.e. the Rohingya people, in Myanmar is something that has been going on for centuries. To this day, there remains a widespread and deep-rooted hostility towards the Muslim minority among the majority Buddhists.
Apparently, Suu Kyi is well aware that any move to speak up for the Rohingya people could cost the NLD its popular support and destabilize her civilian government. Hence, her silence on the issue.
In other words, despite being a Nobel Peace Prize laureate, she'd probably rather give up her halo as the "goddess of democracy" than alienate her Buddhist supporters because it is a matter of life and death for her government. And for that reason, all other concerns, including humanitarian values, have to take a backseat to realpolitik.
As Bangladesh is taking the Rohingya refugee crisis to the UN and demanding that Myanmar take back all the refugees and give them formal citizenship, Suu Kyi may have dodged the issue for now by not attending the UN meeting.
But she can't do that forever. Sooner or later, the Myanmar leader will have to tackle the issue head-on given the seriousness of the problem.
This article appeared in the Hong Kong Economic Journal on Sept. 19
Translation by Alan Lee
– Contact us at [email protected]


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So I've realised a post about the rest of my trip to Cambodia is long overdue. Just to remind you, I went to Cambodia in May this year to attend a wedding. Al, my boyfriend's sister-in-law (his brother's wife) is half Cambodian and one of her half sisters was getting married. Al urged me to come to Cambodia. At first I was really hesitant to go because I'd be a stranger at the wedding. I mean, even Liam wasn't going to be there because he couldn't take time off work. But after some convincing, I said yes and I'm so glad I did.
The wedding was a 3-day epic. Think of the fanciest wedding you've ever been to and multiply it by 100. The night before the wedding, we went to visit Al's family. Their house was still in the middle of construction – adding exquisite drapery and chandeliers to the house etc. By the next day the whole street was transformed into a dining hall, decked out with round tables, plump chairs and a red carpet. The street was tented in PVC, zipped up to trap the air-conditioning (yes, there were about 12+ air-conditioners!).
Earlier that day, Al and I went shopping for a dress. She wasn't keen on wearing her traditional dress but she couldn't find anything she liked. I looked around and found this black dress, which had a pleated skirt. We also got our hair and make up done professionally at a salon the hotel receptionist recommended. It cost me roughly US$12 to get my hair, makeup and nails done, including tips. The lady who did my hair was wonderful and I tried to tip her well. I LOVE my hair! My fringe is so bouncy!
The first day was a bit like a "giving away the bride" ceremony. This ceremony actually went for 1.5 days! The bride and groom were blessed by the monks, exchanged vows and the prime minister of Cambodia and his wife even made it to give them their blessings!
One of the highlights of going to the wedding was seeing the Khmer dresses. There were some amazing silk dresses. Khmer dresses are almost like the Chinese qipao, except it's a top and a skirt, not a dress. Al had a custom-made lilac number on. The styles of dresses were roughly the same, some of the older women had more elaborate details and decals on theirs
It was a very long process, lasting several hours. It wasn't necessary for people to be there for the whole ceremony. In fact the tables outside were set up with food for any hungry patrons. There were people there whose jobs was to offer drinks to everyone while they wait. The actual room where the ceremony took place was tiny so flat screen TVs were hooked up in the dining areas, streaming the ceremony.
Here are some shots of the wedding food. Not great photos because I was too busy eating everything. The food below was the spread for the whole 1.5 wedding ceremony. The food we had wasn't exactly fine-dining, but there was so much of it! Think tables brimming with tasty traditonal, home-cooked dishes. I find Khmer food has a lot of Chinese influences. Think soy-based stir fries with ginger.
Pickled vegies. Its salty-acidic flavour is very addictive.
Some sweet egg rolls, probably made with lots of coconut cream.
Something wrapped in banana leaves. I didn't get a chance to eat that one.
Deep fried fish drenched in a sweet and sour sauce. Very tasty but nothing too amazing. It was a very tasty piece of fish. It actually reminds me of the fish my mum makes at home, except she makes a chinese salt and pepper version with allspice and lots of onion and garlic.
Roast duck in some kind of soy-based sauce. I don't remember this one too well.
Steamed dish of prawns, squid and pork, topped with a mop of coriander. I felt this dish seemed quite Chinese. I had a bit of the prawns and it was nice but nothing exciting.
Deep fried battered bits of pork. Al really liked this. She said it went really well with the dip (pictured below).
Spicy fish sauce with bean sprouts. This was a very addictive dip that went really well with the meats. It wasn't too sickly sweet and packed a decent garlic punch. The bean shoots gave it some texture. I could have eaten it on its own.
Some kind of omelet. I think it had minced pork and wood ear mushrooms. I didn't have any.
Standard spinach stir fry with garlic.
This nasty piece of fish was so yummy. Speared with lemongrass, its flesh was so tender and sweet. I think it must have been grilled. Its tough skin acted as a steamer. It went so well with the dipping sauce with the bean shoots.
The full spread.
These are a dessert. It was a bit like lotus seed paste encased in agar agar. Very delicious. All the photos I took of the insides of the dessert were too blurry. Damn my amateur camera skills!
Anyway, I feel this post is getting quite long. It might be time to end it. I'll post a few more about the other wedding ceremonies and all the touristy stuff I get up to. I hope you enjoyed this!


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1.For condenser microphones, avoid blindly adding phantom voltage
Because the capacitance of capacitor microphone requires polarization to work properly, so when using a condenser microphone, voltage must be illusion. We haveto phantom power switch the mixer is open, bearing in mind the voltage and polarity, otherwise, not only in normal use, may cause damage.
2.Bogey left the microphone sound too far or too close
Microphone pickup best distance is 10 cm or so. "Leadership" speech is far from the microphone, singer with a microphone pickup sounds caused by far too small,such as pushing up volume can easily cause howling; too close to the airflow up into speech, issued a "putt-putt" sound interference.
3.Avoid long time at the microphone, do not exit batteries
Now wireless microphone Conference microphones need to be battery-powered.Such as long periods without a microphone, should quit the battery to avoid battery leakage, corrosion of the microphone.
4.Avoid using microphone doesn't close when power
Completion of the meet to talk or sing, should turn off the microphone switch in time when sound control Division also failed to turn off the mixer volume fader: also picked up other noise on the one hand, on the other hand you some unnecessary speech plays out. President Bush had such an experience, causing embarrassment.
Microphone is really a more expensive item, which is why some big stars have their own dedicated phone customized reasons. Support absolutely necessary for a successful concert as well as a microphone and singing bad microphone is affected. So, in our daily lives, we must pay attention to maintenance of the microphone.
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A lovely Summer's evening, a lovely location, a lovely Anglo Saxon theatre, a lovely community event!
Show time! 'A funny thing happened on the way to Durham'. A comedy based around the Lindesfarne Gospels!
The audience take their seats.
The stage from the seats.
The stage area.
Sold Out!
The play underway. The chap in the middle is the Lindesfarne Gospel! It was excellent.
Our Anglo Saxon designed 'mini thurling' for kids.
One of our storehouses next to the stage.


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By – Chris Porter
Photo – Jim Feeney
Bobby Holmes collected his first checkered flag at the Oswego Speedway Sunday afternoon, winning the 100-lap Race of Champions Sportsman Modified event. Starting from the pole, the Lockport, N.Y. native piloted his No. 22 around Oswego's five-eighths mile atop the field the entire distance.
Holmes (middle) poses with Zeiner (right) and Leaty (left) after winning the R.o.C. Sportsman 100
Only truly challenged after an occasional slip while navigating a turn, being solid on restarts proved crucial for the pilot of the Pizza Logs No. 22. Flurries of caution flags at both ends of the race proved no obstacle for the Dunn Tire Raceway Park regular. Holmes was absolutely thrilled with the win.
Listen to – Bobby Holmes
Three quarters of a lap after Holmes nabbed the initial lead from co-front row starter, Amy Catalano, a modified meltdown occurred in turn No. 3, involving over a half dozen cars.
Nick Cappelli, Tony Hanbury and Daryl Lewis, Jr. went three-wide into the turn, where Lewis spun. The field jammed, collecting Chip Wanamaker, Jessie Kent, Rusty Smith, Eddie Hawkins, Andy Jankowiak and Chris Finocchario. For Hawkins, Jankowiak and Finocchario, the race was over before it had really even begun.
Holmes retained the lead on the restart, but a spin by Craig Dolphin before he could reach the start/finish line kept the field under yellow.
With caution laps counting the field readied itself to take another crack at green flag racing, with 11 of the 12 completed laps having been run under yellow.
Holmes raced to the point position again, but Catalano fought alongside in a bid for the lead. Catalano was actually scored ahead of Holmes as they crossed the line. However, Holmes wrestled back full control of the top spot and the field was off to the races.
Teammates Amy and Dave Catalano nearly came together on the 15th lap after Dave's No. 54 lost momentum. Both regained control, but Amy's No. 64 was sent reeling backwards into eighth place. Zeiner and Buck Catalano would skipped past Dave, moving into the second and third-place positions. Holmes took full advantage of the incident, pulling out to a 10-car length lead.
Buck ducked under Zeiner and with 20 laps in, Holmes continued to hold a dozen lengths on the second and third-place runners. Dave Catalano and Cappelli filled out the top five.
Mike Leaty, Eric Stritzel, Amy Catalano, Hanbury and Matt Kurzejewski completed the top 10.
On lap No. 30, Dave Catalano pulled pitside, promoting Leaty into the top five. On lap No. 32, Holmes tasted his first lapped traffic of the race.
Zeiner and Buck Catalano diced for two laps before Zeiner took over the runner-up spot. Taking advantage of the side-by-side action in front of him, 10th-place starting Leaty moved in on the duo. Leaty would best Catalano for third on the 38th lap.
The caution lights flashed on lap No. 42 after Dick Kluth spun in turn No 2 and Jessie Kent slipped up into the foam in turn No. 1.
Nearing half way, Holmes led Zeiner, Leaty, Buck Catalano and Cappelli. Hanbury, Amy Catalano, Kurjewski, Bryan Sherwood and Jody Buckley rounded out the top 10.
At the drop of the green, Cappelli's No. 86 bounced Catalano's No. 6 back to fifth. A few rounds later, Hanbury knocked the No. 6 back to sixth.
Up front, Holmes continued to race uncontested, a few lengths ahead of Zeiner at the lap No. 60 mark.
All was not flawless for Holmes, who's car began losing its handling shortly after halfway on long runs. Zeiner, Leaty and Cappelli would move in when they could, but couldn't muster a pass attempt on the leader.
Billowing smoke from Kreig Heroth's No. 00 summoned yellow flashing lights on the 74th lap. Hanburny and Buck Catalano took the opportunity to pit for fresh rubber in hopes of finding an extra edge for the 25-lap sprint to the checkers.
Again, Holmes was solid on the restart. However, a bobble off of turn No. 4 by the race leader a few laps in saw Zeiner look high and Leaty take a peek down low. It was a similar bobble by Zeiner that allowed Holmes some breathing room as the laps began to tick away.
A final caution flag was thrown on the 89th lap after Buck Catalano and Bryan Sherwood came together in turn No. 3. Sherwood's No. 95 ended up slapping the inside hub.
This set up a four-lap dash to the finish. Holmes had been flawless on restarts all afternoon and his last one would prove to follow suit. Zeiner could do nothing and Leaty's No. 1 was spent. Holmes cruised to the checkers.
Having won the weekend's showcase event the night before, the newly crowned 2011 Sunoco R.o.C. modified 200 champ came up one spot short of a weekend sweep. Zeiner collected the win in the R.o.C. 100-lap Late Model event as well.
Listen to – Zane Zeiner
Having had his patient run in Saturday night's 200-lapper thrown away after getting caught up in someone else's wreck, Leaty bounced back to earn himself a podium finish on Sunday.
Listen to – Mike Leaty
Having finished third in 2010's R.o.C 100-lapper, Cappelli was able to follow it up with another solid top-five run.
Listen to – Nick Cappelli
Having started up front, Amy Catalano fell back early only to end up working her way back up into the top five at the end.
Listen to – Amy Catalano
Race of Champions Sportsman 100: 1. Bobby Holmes (22), 2. Zane Zeiner (76), 3. Mike Leaty (1), 4. Nick Cappelli (86), 5. Amy Catalano (64), 6. Tony Hanbury (32), 7. Matt Kurjewski (21), 8. Daryl Lews, Jr. (10), 9. Buck Catalano (6), 10. Rusty Smith (34), 11. Andy Lewis (65), 12. Kevin Lewis (41), 13. Bryan Sherwood (95), 14. Jody Buckley (29), 15. Kreig Heroth (00), 16. Dick Kluth (27), 17. Chip Wanamaker (44c), 18. Erich Stritzel (20), 19. Craig Dolphin (98), 20. Dave Catalano (54), 21. Jessee Kent (16), 22. Andy Jankowiak (73), 23. Chris Finocchario (8), 24. Eddie Hawkins (33) *DNS* – T. J. Zacharias (17), Lexi Wilson (2), Jeff Frisbee (2r), Matt Clemens (9x), Russ Brown (13), B. Fitzgerald (39)
Heat race wins went to Leaty, Hanbury, Zeiner and Lewis


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« day before ι day after »
long gallery of independence ι
February 16, 2012
The Long Gallery on the second floor of Independence Hall.
I am touched by the simplicity of the scene.
I have been to Independence Hall twice. The tour in 2008 did not include the second floor.
You had a private tour, I think 🙂
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WASHINGTON (AP)- Jim Webb says he is dropping out of the Democratic race for president and is considering his options about how he might "remain as a voice" in the campaign.
The former Virginia senator said at a news conference that he is "withdrawing from any consideration" of becoming the Democratic party's nominee.
He has complained that he did not get the chance to make his views fully known at the first Democratic debate.
Webb has trailed badly in the field that includes Hillary Rodham Clinton and Vermont Sen. Bernie Sanders. Webb has been polling in the back of the pack with former Maryland Gov. Martin O'Malley and former Rhode Island Gov. Lincoln Chafee.
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Posts Tagged "Projects"
USB Switch Cable
USB Switch Cable
September 8, 2013
Tags : Projects Arduino
The iTunes Rating Device
The iTunes Rating Device
July 19, 2013
Tags : Projects Arduino
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The Gear Clock
July 19, 2013
Tags : Projects Arduino
About Me
My name is Eric Potter. I have an amazing wife and 5 wonderful children. I am a Microsoft MVP for .Net. I am a software architect for Aptera Software in Ft. Wayne Indiana and an adjunct professor for Indiana Tech. I am a humble toolsmith.
Aptera Blog Posts
Posts I have written for the Aptera Blog:


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|Photo: Stéphane Brière
Unit Date of death Initially buried Today buried Grave
KOWNA Jan ???? 24.6.1942 in l'Hôpital de Lille, France In Cimetière Communal de Lille (Nord) Polish War Cemetery, Langannerie, France II.E.2 As a start on this place has been buried ROZKOSZ Franciszek, killed in action 10.8.1944, but his grave was exhumed. Now in this grave has been buried KOWNA JAN but in the existing records of the Polish Air Force he isn't mentioned at all. Anyhow there is put a little memorial plaque as showed above. We like to know who brought this plaque to Langannerie and where has been killed KOWNA Jean? E-mail to firstname.lastname@example.com [more about Langannerie] HOME ABBREVIATIONS ALPHABET


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Ramón Martínez-Mármol1, Mercè Salla-Martret2, Daniel Sastre2, Irene Estadella2, Antonio Felipe2*
The adult mammalian brain contains neural stem cells (NSCs) that generate neurons and glial cells throughout the lifetime of an organism. NSCs reside in at least two germinal epithelium regions of the adult brain, the subventricular zone (SVZ) of the lateral ventricles and the subgranular zone of the hippocampus. Newborn neurons incorporate into the existing functional networks and play important innate and adaptive roles in cognition, behavior and tissue repair1,2. The identity of particular neural stem cells that generate different classes of neurons and glia, as well as the molecular mechanisms that governs this process in vivo, is a subject of extensive research and debate. Epidermal Growth Factor Receptor (EGFR) activation is one of the most important pathways controlling neural stem cell number and self-renewal3,4. On the other hand, the Shaker-type delayed rectifier K+ channel Kv1.3 functions during cell proliferation, differentiation and migration in many cell types5. This channel is expressed in brain progenitor cells where participates in modulating their final fate. This review summarizes the major findings concerning Kv1.3 and neural stem cell modulation, emphasizing the combination of Kv1.3 with EGFR as promising pharmacological targets against autoimmune neuro-degenerative diseases.
Kv1.3 plays important physiological roles and participates in the onset of several pathological dysfunctions in many non-neuronal cell types, such as T-cells6, platelets7, microglia8 and macrophages9. Kv1.3 blockade in T-cells results in depolarization, inhibition of activation and the attenuation of immune responses in vivo. Similarly, the inhibition of Kv1.3 in microglia reduces activation and prevents neurotoxicity10. In neurons, Kv1.3 is particularly important for maintaining tonic firing during sustained depolarization11. However, the contribution of Kv1.3 in controlling the proliferation of adult neural precursor cells remains controversial. Although some authors do not confirm the pharmacological expression of Kv1.3 in adult neural precursor cells (NPCs)12, others identified gene and protein expression in adult rat mesencephalic-derived neurosphere NPCs13 and oligodendrocyte (glia) progenitor cells (OPCs)14. The apparent discrepancy concerning Kv1.3 expression in brain progenitor cells may be associated with the developmental timing and anatomical origin of brain samples. Kv1.3 was not functionally detected in adult mouse NPCs obtained from primary neurospheres derived from the forebrain SVZ12 but was expressed in adult rat mesencephalic-derived neurosphere NPCs13 and OPCs from rat neonatal cerebral cortex15,16. Results from our lab indicated the possibility that Kv1.3-positive cells may be more abundantly expressed in the posterior region of the SVZ (pSVZ), as primary cultured cells and neurospheres derived from this brain area contained functional Kv1.3 channels17. Our results are consistent with the facts that pSVZ contains progenitor cells that generate glial cells18,19 and that Kv1.3 is functionally expressed in OPCs from the SVZ.
Large Kv currents have been described in proliferating OPCs, whereas post-mitotic oligodendrocytes do not express such currents15,19. In fact, Kv1.3 is a key element in OPC proliferation, playing a crucial role in the G1/S transition15. Moreover, while overexpression of Kv1.3 increases OPC proliferation in the absence of mitogens, it has minor effects on the early stages of the oligodendrocyte differentiation and slightly increases the formation of O4+ pro-oligodendrocytes16. In addition, genetic and pharmacological inhibition of Kv1.3 increases the neuronal fate among differentiated NPCs20. In contrast, evidence indicates that selective blockage of Kv1.3 increases adult murine mesencephalic NPC proliferation, based on the model of long-term cultured neurospheres under non-differentiating conditions13. Consistent with these studies, granzyme B (GrB) released by T-cells increases the expression of Kv1.3 within NPCs and hampers NPC proliferation and neuronal differentiation. Blocking Kv1.3 with margatoxin or with specific shRNAs abolishes the inhibitory effects of GrB on NPCs21. The above-mentioned results hindered a direct interpretation of Kv1.3 function, possibly suggesting different roles for Kv1.3 in controlling stem cell proliferation and differentiation.
EGFR stimulation in vivo drives proliferation in the SVZ22,23 modulates proliferation and migration of SVZ type-B astrocytes in vitro23 and enhances migratory oligodendrocyte precursors in the rostral migratory stream24. Furthermore, the infusion of EGF into the lateral ventricle triggers the migration of SVZ cells from their normal route into the adjacent striatum and septum25. Furthermore, EGFR overexpression during early postnatal development promotes SVZ-to-lesion migration, enhancing oligodendrocyte generation and axonal myelination3. However, EGFR can also inhibit axon regeneration26 by blocking Myelin Basic Protein (MBP) production into matured oligodendrocytes27. This apparently contradictory EGFR function could respond to different roles during recruitment-migration and differentiation-myelination phases of oligodendrocyte life. The mechanism behind this change of behavior remains unknown. In this context, integrins, interacting with extracellular matrix (ECM) components, participate on the cell adhesion and motility28. β1 integrin is required for propagating the EGFR signaling from the plasma membrane to the nucleus by sustaining the EGFR-dependent endocytic machinery29. β1 integrin expression diminishes during oligodendrocyte differentiation, concomitantly with a decrease into their migratory potential30. Genetic ablation of β1 integrin generates a deficit in myelination31, suggesting that basal levels of this protein are required in oligodendrocytes to extend their myelin sheets. Kv1.3 associates with β1 integrin32,33. Evidence suggests that the activation of Kv1.3 triggers conformational changes into neighboring integrins. Because the Kv1.3 pharmacological blockade or integrin detachment to ECM can disassembly the supramolecular complex this issue is worth of study during oligodendrocyte life. Kv1.3 is modulated by EGF signaling pathways and, interestingly, we recently described a reinforcement of the EGF effect on NSC migration by blocking Kv1.3 in SVZ-derived explants. Via detailed analysis of the molecular mechanisms governing this effect, we demonstrated that Kv1.3 activity is reduced by EGFR activation in an unconventional dual pathway, comprising both tyrosine phosphorylation-dependent inhibition of activity and p42/44 MAPK (ERK1/2) threonine phosphorylation-dependent internalization of the channel17. Contrary to previous reports, the EGFR activation initiates a signaling cascade that decreases current amplitude via both covalent modification of the channel and diminishing Kv1.3 abundance at the surface. Therefore, evidence suggests that EGFR activation and downregulation of Kv1.3 acts synergistically to promote NSC proliferation and migration. It is not known whether Kv1.3 internalization affects β1 integrin activity. Whether Kv1.3 endocytosis would somehow inhibit integrin function, this could represent a potential mechanism to counteract the activity of EGFR and shorten its effect, possibly driving the cells to a more differentiated state. The activity of Kv1.3 together with β1 integrin could be associated with the maintenance of a proliferative state. The down-regulation of the channel associated with EGFR activity could act as an initial mechanism to counteract the activity of this mitogen and initiate the differentiation of oligodendrocytes. However, further research should be done in this respect.
Kv1.3 and EGFR are promising pharmacological targets for developing new therapies against inflammatory-associated neurodegenerative diseases such as multiple sclerosis (MS), brain infarction and other demyelinating disorders.
For example, lysolecithin (LPC)-induced focal unilateral demyelination of the corpus callosum upregulates VEGF and EGFR ligands (HB-EGF, TGFα) in the SVZ34. Similarly, focal cerebral ischemia is associated with elevated EGF levels and increased NPC proliferation in the SVZ35. In cultured SVZ cells, EGF induces oligodendrogenesis and subsequent myelin production34. Adult SVZ GFAP+ type-B astrocytes exhibit a positive dose-dependent effect of EGF on proliferation and migration. These Olig2+ NG2+ cells are highly migratory and proliferative and differentiate into S100b+/O4+ oligodendrocytes upon EGF withdrawal23. Thus, EGF may induce SVZ-oligodendrocyte progenitors to migrate, differentiate into oligodendrocytes and finally remyelinate injured white matter36. Conversely, reduction of EGFR signaling in NG2-expressing progenitors decreases SVZ-to-lesion migration of NG2+ cells and the subsequent oligodendrogenesis and remyelination rates. This demonstrates that the NG2+ cell response in the SVZ and the subsequent differentiation of these cells after focal demyelination are dependent upon EGFR signaling34. Accordingly, EGFR overexpression in NPCs in vivo expands and accelerates oligodendrogenesis, axonal remyelination and functional recovery in the LPC-induced model of demyelination. Injured areas are repopulated by NG2+ Mash1+ Olig2+ progenitor cells3. The elevated EGFR signaling reduces neurogenesis in favor of oligodendrogenesis. This is due to an induced expansion of the SVZ-NPC pool and the concomitant reduction of NSC number and self-renewal through an EGFR-mediated regulation of Notch signaling4. Altogether, these results demonstrate that EGFR signaling in vivo is involved in oligodendrocyte development and remyelination. In this context, EGF administration has been used as a therapeutic approach to counteract demyelination. The cerebrospinal fluid of MS patients in the relapsing–remitting or secondary-progressive clinical courses is characterized by a deficiency in the myelinotrophic factor EGF37. This deregulation in the synthesis of growth factors in MS CNS appears to be involved in the inhibition of remyelination38. Concomitantly, EGF administration positively affects myelin repair in the rat spinal cord white matter39. Co-administration of EGF and growth hormone releasing peptide-6 reduced inflammatory infiltration and microvascular damage associated with EAE, thereby improving the clinical recovery40. Intranasal heparin-binding EGF (HB-EGF) administration increases SVZ cell proliferation and mobilization towards LPC-demyelinated injured areas and a subsequent differentiation shift towards the astrocytic lineage41. Similarly, immediately after injury of neonatal mouse brain, intranasal HB-EGF infusion decreases oligodendroglial death, enhances generation of new oligodendrocytes from progenitor cells and promotes functional recovery by diminishing ultrastructural abnormalities42.
In this scenario, our results17 support a dual role for EGF-signaling and Kv1.3 function in controlling multiple and complementary relevant aspects of the progression of demyelinating disorders (Figure 1). Therefore, the manipulation of either and preferably both of these elements might ameliorate the neurodegenerative progression. EGF administration would enhance remyelination from SVZ-derived OPCs. Inhibition of Kv1.3 with therapeutically usable compounds, such as analogs of a sea anemone toxin43,44, or psoralene dirivatives45, would hamper the cytotoxic effect of inflammatory infiltrates, acting simultaneously on activated lymphocytes and proliferating OPCs. Thus, EGF supplementation might be a useful adjunctive for Kv1.3 inhibition in treatment of MS, brain infarction and other demyelinating disorders. In addition to the pharmacological targeting of specific host cells, stem cell therapy represents a promising alternative in the treatment of neurodegenerative processes (e.g., MS) and brain tissue damage (e.g., after hypoxia). Thus, simultaneous control of EGF and Kv1.3 might provide more effective ways to control growth, proliferation and differentiation of stem cells used for the treatment of neurodegenerative disorders or for CNS regeneration.
Figure 1: Schematic representation showing the action of the EGFR activation and Kv1.3 inhibition on a neuronal demyelination repair process. A) Sagittal and frontal representation of the postnatal mice brain. B) After demyelination, the inflammatory response triggers the release of factors activating proliferation, migration and differentiation of SVZ-derived OPCs. Cells differentiate into mature myelinating oligodendrocytes extending a new myelin sheath around the demyelinated axon. C) The activation of EGFR pathway and/or the inhibition of Kv1.3 would recruit SVZ-derived OPC into the damaged area, thereby improving the remyelination. Blue, axon; dark green, old myelin sheath; light green, new myelin sheath. D) Molecular mechanism of the EGFR on Kv1.3. Activation of EGFR pathway induces both tyrosine and threonine phosphorylation of the channel. Threonine phosphorylation via Ras/Raf/MEK/ERK pathway triggers clathrin-coated pits-mediated internalization of Kv1.3. Channel downregulation and EGFR activation cooperate to positively modulate proliferation, migration and differentiation of OPCs. OB, Olfactory bulb; RMS, Rostral migratory stream; CC, Corpus callosum; LV, Lateral ventricle; SVZ, Subventricular zone; CSF, Cerebrospinal fluid; OPC, Oligodendrocyte precursor cell.
The work carried out by the Molecular Physiology Laboratory was funded by Ministerio de Economia y Competitividad (Spain) grants from the BFU (BFU2011-23268, BFU2014-54928-R), Fondo Europeo de Desarrollo Regional (FEDER) and CONSOLIDER (CSD2008-00005) programs. The editorial assistance of the American Journal Experts is also acknowledged. The Molecular Physiology Laboratory would like to acknowledge all past members who have contributed to this research.


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I think I'm beginning to surface from an extraordinarily difficult period in my life. I've been reflecting a lot about it these past few weeks and, while watching my subscriber numbers drop, it's made me ask whether we really appreciate the toll of entrepreneurialism and innovation.
Grab Handles
I listed them separately - entrepreneurialism and innovation - because I see them as vastly different. The former is usually about creating new value, such as a product or service, that can take a slice of an existing market. Innovation is about forming new types of value for which a market may not yet exist. In my view, innovation is way harder than entrepreneurialism because you don't have the grab handles of the existing market to steady the journey. You have to make your own grab handles along the way.
I don't believe observers and commentators really understand how unsettling it is to innovate - to operate in a space that doesn't yet exist, a space in which there are no grab handles to steady the journey. For all the talk of 'innovation' (most of which is actually about entrepreneurialism), there is little to none about the impact on the people trying it.
There needs to be.
From Within
I was reminded of all this when a fellow innovator popped round to see me after my knee surgery. We talked about just how tiring innovation is; building the space through narrative, occupying it with a product or service, and then trying to sell it - so establishing a price point and hence a potential market. It takes relentless energy, bravery, belief and support, most of which has to come from within because few 'outsiders' truly understand the challenge.
I experience this lack of understanding all the time. The way it manifests most often is when well-meaning friends, all of whom understand the financial struggle of my work, look for ways in which I can make money. Charge them for this! Charge them for that! My friend's doing X and got paid Y so you should be able to ask for Z...
99.9% of the time what these friends are doing (other than genuinely caring) is using the rules of existing markets. That's all well and good if you're an entrepreneur, but not if you're an innovator. The 0.1% that 'get it', offer examples from other markets as a way to feed the creative process of market making - something that most entrepreneurs don't have to deal with.
Talk Ain't Cheap
Innovators have to deal with a lot more uncertainty than entrepreneurs, and most human beings don't handle uncertainty well. For me, just being able to talk about it helps, which is why, at times, this blog likely becomes a place of neurotic introspection. Part of me thinks I should keep such insecurities to myself. And yet, I've heard a few readers - often fellow innovators - tell me how much they like that someone is talking about it.
By design, innovators think out of the box. But also by design, our comforts, our grab handles, are inside the box. That's not something that's likely to change but what could change is the external support innovators might be able to access.
Pritpal S Tamber
I'm the Co-Founder & CEO of Bridging Health & Community (BH&C) and the Founder of the Creating Health Collaborative. Before all this, I was the Physician Editor of TEDMED, Medical Director of Map of Medicine, and Editorial Director for Medicine at BioMed Central, the company that pioneered open access publishing. I have an MBChB (the UK equivalent to an MD) from the University of Birmingham, UK. This is my personal blog. If you're interested in BH&C or the Collaborative, check out the updates on their website or receive them by email.


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Walkers, ramblers and amblers have a great chance to explore the wonderful woods on our doorstep when Market Rasen Walkers are Welcome Group launch their new map of Willingham Woods at the Picnic Area in Willingham Road.
The celebratory launch will take part on Saturday May 9 from 9.30am.
Walkers are Welcome chairman Gary Beighton said: "People have been afraid to venture much beyond the picnic area for fear of getting lost.
"With our new map and leaflet they will be able to explore the woods safely as far the Tealby Road and Hamilton Hill."
Group member, Paul Hiley, said: "We want the public to try out the map and see how they get on.
"There will be friendly help on hand if needed and one of our team will lead a guided walk leaving the Picnic Area at 11am."
Walkers are Welcome is a national organisation committed to encouraging walking and making walkers welcome in their areas.
The Market Rasen branch is always looking for new members(www.waw-rasen.org) and has plans to make the woodland even more attractive to all ages in the future.
This project has been part funded by West Lindsey District Council with support from Community Lincs and co operation from The Forestry Commission.
Please be considerate to other people when using the woods, use the litter bins and doggy bins provided and keep dogs under control.


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Literature Research
Design limits for composites tend to be much lower than their capability due to poor impact strength [8]. Improving toughness will reduce the need for excessive safety factors and thus enable a great reduction in weight for high performance composite products. For this reason there is a large body of literature focusing on methods to improve composite toughness. The aim of this literature research is to find the relative effectiveness of all the available toughening methods and to determine which methods are most appropriate for each manufacturing process. Further aims include finding novel production processes and fibre/matrix combinations that yield good strength, stiffness and toughness. This knowledge will inform later design decisions. 108 papers were categorised, of which 95 have been summarised. Figure 16 shows a diagram of the category breakdown with the number of papers in each area. The literature review is summarised below.
Figure 15: A summary of research categories relevant for composite materials in rock climbing.
Toughening methods
The main toughening methods are based on using different forms and combinations of fibres. The methods are: stitching, weaving, knitting, z-pinning, hybridising, outer protective layers and interlayers. Z-pinning, knitting and 3D-weaving appear to offer the very promising benefits - with z-pinning showing improvements in mode I and II toughness of up to an order of magnitude [32]. In addition, damage area is reduced and compression after impact strength is increased [33]. Z-pinning is where narrow composite pin-reinforcements are inserted perpendicular to the composite surface - giving the structure greater out-of-plane strength (figure 17).
Figure 17: Z-pins visible after pullout [34].
3D woven laminates are more compliant than unidirectional tape based laminates; this means that more of the impact energy is absorbed by the response of the structure rather than through delamination [35]. In addition, the weave pattern helps to reduce the propagation of shear and delamination cracking. Knitted reinforcement (figure 18) has been compared with woven reinforcement - it was found that, after impact, the knitted laminates adsorbed more energy (and sustained more damage) but their residual tensile properties remained higher [36].
Figure 18: Various knitting patterns. Knitted composites maintain greater tensile properties after impact compared to their woven counterparts [36].
The toughness of the matrix material has been shown to have a very strong influence on the toughness of the composite [37, 38]. Using a tougher matrix increases the damage initiation load by increasing G IIC .
Using a toughening agent, for example rubber particle toughening, would normally improve toughness at the expense of stiffness. Adding alumina nanoparticles to an epoxy resin can improve both toughness and stiffness [39]. Adding 1-2% alumina particles was shown to introduce new energy dissipating mechanisms - shear yielding of the matrix, particle pullout and crack pinning. Adding calcium silicate microparticles into the nanoparticle composite improved wear resistance by a factor of three, the impact energy stayed above that for the neat matrix but the strain to break decreased significantly.
Combining different types of fibre in a composite is called hybridization. The aim of hybridization is generally to combine two types of fibres, with very different properties, to attain the benefits of both. For example, a high modulus fibre might be used in combination with tougher fibres to give a composite both stiffness and impact resistance. It has been shown that, in laminated composite, alternating layers of glass and carbon fibre reduces notch sensitivity compared to pure glass or pure carbon fibre laminates [55]. The effect is amplified if the layers are ordered such that carbon fibre is on the outside. Furthermore, this layering improves the compressive strength after impact as the damage area and crack lengths are reduced.
For woven hybrid composites it has been shown that interply are tougher than intraply hybrids in low velocity impact [40]. In an interply hybrid each layer containing only one fibre type - but fibre types alternate in successive layers. In an intraply hybrid each layer contains a mixture of both fibre types. The interply hybrid showed a 9-67% higher specific energy adsorption, a 5-45% lower peak load and an 8-220% higher ductile index.
Hybridization in random oriented short fibre reinforced composites has been shown to significantly improve tensile strength and modulus, flexural strength and modulus and marginally improve toughness [41]. Thermotropic liquid crystalline polymer (TLCP) fibres were added to a carbon fibre reinforced PEEK matrix (figure 19), the TLCP fibres were around an order of magnitude smaller than the carbon fibres (0.3-1.5 µm compared to 7 µm). The TLCP fibres also reduced the melt viscosity - enabling easier processing.
Figure 19: Adding smaller TLCP fibres to a short fibre reinforced matrix improves mechanical and processing properties [41].
Short shaped copper fibres have been shown to improve toughness [42]. Shaping the fibres affects the fibre/matrix interface and, when combined with a tough matrix, shaped fibres perform better than their straight equivalents. Another toughening method, which makes use of interlaminar fibres, has been shown to reduce damage area and severity [43, 44]. Short fibres are sprinkled in between layers before curing; this increases the out of plane strength.
The volume fraction of fibres is a major determining factor for composite mechanical properties. For injection moulded polypropylene, with long discontinuous glass fibre reinforcement, there is an optimum percentage of reinforcement for maximising strength and toughness [45]. Stiffness was found to increase linearly with fibre content up to the maximum possible of 73% weight; whilst the maximum content for strength and toughness was found to be 40-50% weight.
Consolidation temperature and cooling rates have been shown to affect toughness [46-48, 49]. Rapid cooling increases matrix toughness but reduces tensile strength due to reduced crystallinity - a compromise must be met to achieve sufficient strength whilst optimising toughness. Similarly, a lower consolidation temperature increases matrix ductility - improving composite toughness.
The properties of the interphase (the region of resin close to the reinforcement fibres) can be very different to those of the bulk resin [50]. The interphase plays a crucial role in determining the overall strength and toughness of a composite. Its properties can be tailored to optimise strength and toughness by using appropriate sizings (surface treatment on the glass fibres) to affect the fibre/matrix bond.


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It's day 5 already and we just arrived in Palmyra, New York at Fellowship Bible Church. The ride was much smoother and faster than the past few hilly days. Immediately after arriving we were shuttled to showers which felt great after 80 miles in the warm sun. I felt extremely welcomed at our stayover and had lots of fun playing board games and telling jokes with Ezekiel, Isaiah, and Gracie:) Dinner(lasanga, salad, and fruit), dessert(cupcakes, brownies, and toffee!), and breakfast(muffins, eggs, and fruit) tasted delicious and served as a nice change from the usual pasta and lentils(even though I enjoy those too!).
Palmyra to Rochester
Day 6 already…one more day and it will be a week of biking. It feels like we have been biking for months as the days fly by so fast. Today was a short 23 mile day so we had plenty of time to visit Gilda's Club and the Hope Lodge. Along with several teammates, I visited Gilda's Club, a cancer support facility, and spoke with members who have experienced cancer in their lives. It was inspiring to see the comfort these individuals found at Gilda's and the fun ways Gilda's offers support(social dinners, cooking classes, exercise classes, crafting, etc.) We were able to collect a few portraits for the Portraits Project as well! In less than 12 hours my team and I will begin our ride to Niagara Falls! This will be my first time seeing the falls both from the American and Canadian side…stay tuned to see the pixs:)


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Herbal Medicine Manufacturer and Supplier- Innovexia Lifesciences has highly engaged in manufacturing and supplying the wide range of Herbal Medicine. Herbal Products are extensively used for treating any kind of issue naturally. Due to their rich natural ingredients, These products are highly demanded in the market. Many people prefer herbal range as compared to any other. In order to fulfill this demand of this particular drug, we have introduced ourselves as the leading Herbal Medicine Manufacturer and supplier.
With the help of our vast infrastructure facility, we are capable to deliver the bulk quantity range of Herbal Medicine to our esteemed clients. All our skilled workers and the team of experts applies the proven techniques and methods for delivering the premium quality Herbal Drugs. Being a leading Herbal Medicine Manufacturer and Supplier, we are capable to deliver the variety of drug range to our esteemed clients.
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In the initial stage of any business, it is quite hard to establish an infrastructure as it consists the huge costs. Setting up a whole manufacturing unit is tough. In such case, people seek for the Manufacturer and supplier company to whom they can ask for bulk quantity range of products. Our company is helping all those pharma professionals, who are dealing in Herbal Medicine Range. We are providing them the bulk quantity range of drugs at reasonable prices. Here is the list of achievement that our company has made from its starting:
Herbal products have been using numbers of people since ages. People rely on these type of products due to its effective nature and cost-effectiveness. These products are made using pure chemical extracts which are easily available in nature. Thus the manufacturing costs of these type of medicine are low. Apart from this, these medicines can be used by any age group of people. Introducing a pharma firm in this drug range would be beneficial for you in many ways.
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Being a leading Pharma manufacturing company, we have to execute all the work with extream care. We try our level best to perform every task with extreme care. We have made separate department in our company so that our every work will take place with efficiently. Here is the name of this department:
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Frederick Akhelumele – Nigeria
Linked with our presentation of Youthcare International.
Linked also with our presentation of Some reports on Africa and Education.
Mr. Frederick Akhelumele – a Nigerian school teacher who has lived in Austria for many years, founded the organization in August 2002. Since then, Mr. Akhelumele has embarked on a mission to give children in Nigeria and other developing countries a brighter future through the agency of Youthcare International.
Frederick Akhelumele – Nigeria
In the final week of October, 2005, Dr. Rupp and a small team of Austrian sponsors visited Nigeria for four weeks. There they attended the official opening of the Ebhebe Project and experienced the first few weeks of the school in action. Below is a report from Dr. Rupp.
On the 25th November 2005, the school was officially opened in the presence of many important members of the Nigerian society including politicians, religious leaders, educators, doctors etc. Currently the school has eleven highly qualified teachers who instruct the classes according to the West African curriculum. The standard of education is quite high and comparable to European standards. Remedial teaching is also ongoing for a number of children between the ages of 12 and 14, who still cannot read and write properly. Healthy snacks are available to the children during the breaks. The children have often expressed how happy and proud they are to be attending the school. Security is provided by competent watchmen 24 hours per day. Mr. Akhelumele, the founder of Youthcare International, has remained there to teach and supervise the project. The executive directors from the Austrian company "print & more", Mr. Wolfgang Winkler and his wife Mrs. Angelika Winkler donated 2000 schoolbooks. Although start-up has been quite successful and inspiring, we still need a lot of support to sustain the current classes and to implement other vital aspects of the project. These include upgrading the current classes, finishing the kindergarten, completing and outfitting the computer centre, maintaining the remedial teaching programme for children and improving our efforts to disseminate information about AIDS. (Written on 09. Nov. 2005, read more on this page of Youthcare International).
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text: Home Support us Events and fundraising London to Paris Cycle London to Paris Cycle Register now Location: England, France Date: 05 Jun 2019 - 09 Jun 2019 Cycling from London to Paris is one of the classic cycle experiences in Europe! Pedalling out of London and through picturesque Kent countryside, you will cross the Channel and through the small villages and medieval market towns of Northern France. You will arrive in Paris to see the legendary sight of the Eiffel Tower on the skyline, evoking a real sense of achievement. On your final day in Paris you will have the opportunity to explore the sights and soak up the atmosphere of the city! Download the full itinerary for more information. Cost information When you register for this event, you can choose your fundraising option. Registration fee Cost of trip Fundraising target Fundraising option £149 £0 £1,600 Part-payment option £149 £250 £1,100 Self payment option £149 £800 Raise as much as you can Once you have signed up for this event, we will support you by providing: Fundraising pack full of ideas and advice. Hospice UK t-shirt and fundraising materials. Dedicated point of contact in the Events Team. Please note that this is an open challenge facilitated by Discover Adventure, so there will be participants supporting other charities on this trip. Register now


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ERIC Number: ED233283
Record Type: RIE
Publication Date: 1983-Mar
Pages: 68
Abstractor: N/A
Reference Count: 0
The Effects of Doctoral Study on Marriage and Family: An Ethnographic Study.
Giles, Francine
Stresses which accompany graduate education are often a source of marital conflict and disruption for students and their families. To investigate the effects of the graduate experience on intra- and inter-family relationships among married doctoral student couples, and to discover how these students cope with the dual student/spouse role, 16 full-time married doctoral students (8 males and 8 females) and their non-enrolled but employed spouses participated in ethnographic interviews over a 6 month period. Results of ethnographic analyses highlighted four recurring themes: (1) support from spouse and parents (financial, emotional/psychological, academic, and basic needs); (2) factors affecting marital stability (i.e., financial problems, time pressures, children, communication, sexual concerns, role conflict, physical and emotional separation); (3) social relationships and interaction (influenced by such factors as interest in status changes, absence of married peers, fears associated with terminating relationships upon graduation, and special needs of the non-student); and (4) status (affected by such factors as living arrangements, student-spouse role conflicts, measurement of status through enrollment and grades, locus of control, and financial conditions). The results have implications for the role of university and student affairs professionals who deal with the married graduate student. The telephone interview and interview questions are appended. (Author/WAS)
Publication Type: Reports - Research; Speeches/Meeting Papers; Tests/Questionnaires
Education Level: N/A
Audience: Researchers
Language: English
Sponsor: N/A
Authoring Institution: N/A
Note: Paper presented at the Annual Meeting of the American College Personnel Association (Houston, TX, March 13-16, 1983).


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I'm trapped under a baby with a computer on my lap so I have some time to post Henry's six-week photos. So hard to believe how much faster time flies with No. 3. I'd like to know the cosmic explanation for this phenomena.
In other news, Michael went to the dentist for the first time this week. He did great.
And because I can't help myself, here are some more snapshots of Henry from the past week.
See? Sometimes he's awake.


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Just curious, what do y'all base this "like v/s dislike" on? Looks? What you perceive from the outside? Try to figure out, and work on a ridiculously designed hydraulic gate mechanism, try to adjust a WCH gate mech -and keep it in adjustment afterwards, and have to be aggrivated with their contacts and sticking cover doors, try to keep a long, heavy gate arm from slipping the clutch on a GRS gate mech, or try to keep a gate up without power with a WABCO gate mech, then come back and tell me how much you still love them.
Safetran hands down has the absolute best gate mechanisms in the industry, they perform strong, smoothly and continously under extreme conditions when given even minimal basic care. There really is no comparison.
When you get out there and work with them for a while, then come back and tell me why one is your "favorite" over another.
....Is "Triangle" a gate mechanism??


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Cadbury Egg Hunt at Souter Lighthouse
Follow in Bunny's footsteps to track down a delicious Cadbury chocolate treat.
A lighthouse isn't where you'd usually expect to find bunnies, but we've had a very special visitor at Souter.
Bunny took a trip to the coast to hide clues for you to find on a Cadbury Egg Hunt. Brush up your best detecting skills and search Souter for Easter evidence. Discover all the clues to find a delicious Cadbury chocolate treat. You can create Easter crafts too.
Friday 14 - Monday 17 April, 11am - 4pm. No need to book. Find the fun in the Foghorn Field £2 per child.
Every single Cadbury Egg Hunt will help support special places looked after by the National Trust for future generations to explore.