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Dissolved CO2 should have minimal impact BUT. . . CO2 bubbles in solution however could have a large impact on the gravity reading. Make sure that you de-gass the sample and you should be fine.Fred
+1Just agitate the beer for a minute or two and take your reading adjusting for temp.


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Back at the beginning of the year, Google had the mobile industry at the edge of its seat as it unveiled the HTC-made Google Nexus One, touting the device as a "superphone" that raised the bar for the entire smartphone industry and introducing a Web-only retail model for consumers to set their hands on the device, via partnerships with T-Mobile and AT&T. Now, following a difficult launch, Google learning that tech support for phones is neither simple nor easy, and having both Sprint and Verizon Wireless backing out of carrying the device, then shutting down that oh-so-innovative online phone store, Google is finally pulling the plug: one the current batch of Nexus One phones are sold, Google says the device will no longer be for sale in the United States.
"This week we received our last shipment of Nexus One phones," Google wrote in a blog post. "Once we sell these devices, the Nexus One will no longer be available online from Google. Customer support will still be available for current Nexus One customers."
Google says the Nexus One will continue to be offered by overseas partners, including KT in South Korea and Vodafone in Europe.
Although the Nexus One generally got positive reviews—leaving aside complaints about carrier service—the phone only managed weak sales (especially compared to the iPhone and the original Droid, which launched just before the Nexus One). The Nexus One was the first Android phone to get Android 2.2 "Froyo;" however, as a handset the device is quickly being eclipsed by devices like the HTC Evo 4G and Droid Incredible, the new Droid X, and the raft of Samsung Galaxy S handsets landing now at U.S. carriers. And, of course, the iPhone 4 continues to cast a long shadow on the mobile marketplace, antenna issues or no.
With the Android operating system now firmly launched into the mobile marketplace, the Nexus One might mark Google's only branded foray into the smartphone arena. Google seems to have regarded the Nexus One as a way to test Android in the marketplace, as well as see if mobile consumers were ready to by phones via the Web rather than retail stores. Android seems to have been well received; Google online store and support, however, seem to have earned a shunned by phone buyers.
*Editors Note 7/19/2010 – We corrected the launch date of the Motorola Droid to reflect that it came out BEFORE the Nexus One, not after
Editors' Recommendations
- How to unlock a phone on every carrier
- Google Fi: Phones, plans, pricing, and perks explained
- When is your phone getting Android 8.0 Oreo? We asked every major manufacturer
- When is your phone getting Android 9.0 Pie? We asked every major manufacturer
- How to sell your iPhone 7, iPhone 8, or iPhone X (without getting ripped off)

subset: commoncrawl


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The powers of the emergency manager under Public Act 4 of 2011 are materially different from those of the emergency financial manager under Public Act 72 of 1990. As stated above, however, the most material alterations were allowing the emergency manager to modify, reject or terminate the terms and conditions of contracts and — under certain conditions — collective bargaining agreements.
Providing a power to alter collective bargaining agreements has a practical basis. The primary expenses of most local units of government are not in materials, utilities or vendor contracts. They are in the cost of personnel. In Michigan, most local government personnel are unionized, and their compensation is determined by collective bargaining agreements.
There are several conditions that must be met before an emergency manager can unilaterally alter collective bargaining agreements under Public Act 4. The emergency manager needs to first meet and confer with union representatives. He or she then needs to determine that "a prompt and satisfactory resolution is unlikely to be obtained"[49] regarding alterations to a union collective bargaining agreement.
While these may seem like subjective determinations, a collective bargaining agreement can be amended only if the state treasurer and emergency manager make a series of determinations: that the intervention is "reasonable and necessary" in achieving a "significant and legitimate public purpose" and addressing "a broad, generalized economic problem"; that the amendments are "directly related to and designed to address the financial emergency for the benefit of the public as a whole"; and that the amendments are temporary and do not "target specific classes of employees."[50]
These conditions are reflective of constitutional requirements that grant states a limited ability to amend contracts.[*] They also prevent an arbitrary abrogation of the agreements made by elected officials. The treasurer and emergency manager's conclusions can be challenged in court if the union believes that they have not been met.
The use of this power has been relatively light. Only three of the seven governments with emergency managers — Detroit Public Schools, Pontiac and Flint — have utilized this section of the law, amending at least 26 collective bargaining agreements. [†], [51] A number of these amendments were designed to get the contracts under uniform terms. These amendments provided substantial savings to the local units.
For instance, Pontiac's emergency manager was able to negotiate changes and consolidate most of the city's 70 different health insurance offerings into a single plan. He was not able, however, to negotiate changes to retiree health insurance.[52] He requested permission to change this benefit unilaterally from the state treasurer, who approved his plan to consolidate retiree health care, cap the city's costs and provide the government flexibility in choosing plans and providers. The city is expected to save nearly $3.4 million annually, thereby eliminating more than 45 percent of the city's projected operating deficit.[53]
Likewise, Flint had negotiated 20 different insurance plans for current employees and retirees.[54] Consolidating these plans into just three was expected to save nearly $7.9 million annually for the city — 44 percent of its projected operating deficit.[55] The savings from emergency managers' modifications to contracts in Pontiac and Flint is summarized in Graphic 2.
Note that offering health insurance coverage to retirees is a rare benefit in Michigan's private-sector. In a 2010 AonHewitt survey of 24 major private-sector Michigan employers, only three offered some form of employer-subsidized retiree health insurance coverage.[56]
Graphic 2: Estimated Savings From Modifications to Government-Employee Union Contracts in Flint and Pontiac Under Public Act 4, 2011-2012
Source: Various Michigan Treasury Department letters of determination to Pontiac and Flint Emergency Managers, 2011 and 2012.
The emergency manager for Detroit Public Schools abrogated a number of collective agreements, adding into their non-teacher union collective bargaining agreements such common terms as pay cuts, suspension of terminal sick leave,[‡] suspension of longevity bonuses,[§] suspension of step increases[¶] and a requirement that employees pay 20 percent of their health insurance premium. These changes led to an estimated annual savings of $15.4 million to the district.[57]
Modifications to the DPS' collective bargaining agreement for the district's 6,000 teachers included ending special bonuses for each of the following: teaching an oversized class, losing a preparation period, receiving advanced certification, and teaching special education. Extra payments if the teacher was assaulted were also ended.[58]
Notably, the emergency manager sought approval from the Department of Treasury to alter the terms of the teacher collective bargaining agreement only after 11 meetings with union leaders. The changes to the teachers' contract are estimated to save the district $70.1 million annually,[59] leading to a total estimated annual savings of $85.5 million from DPS union contract modifications. A summary of the savings achieved by the DPS emergency manager using modifications to the collective bargaining agreements appears in Graphic 3.
Graphic 3: Estimated Savings From Modifications to Government-Employee Union Contracts in the Detroit Public Schools Under Public Act 4, 2011-2012
Source: Detroit Public Schools Emergency Manager Roy Roberts, 13 letters to State Treasurer Andy Dillon, June 23, 2011 and June 26, 2012.
The modifications discussed above are structural reforms dealing with the costs of providing services. They affect the terms of employment, but do not directly affect service quality or quantity. In short, they are efficiency gains.
It is true, of course, that reductions in compensation can affect employee service quality indirectly. Emergency managers would presumably try to account for this in the modifications they make, but inevitably, they could make decisions that ultimately reduce service quality. Nevertheless, it is not clear that court-supervised receivership or bankruptcy would lead to more judicious decisions.
The emergency manager's power to change union contracts may not need to be used to be useful. It may affect union negotiations, tipping the bargaining table more towards the emergency manager and his or her mandate to address the city's finances.
The November 2012 ballot presents an interesting wrinkle. If Proposal 2 passes, union contracts would gain the power to supersede most state laws governing wages, hours and other terms and conditions of employment.[60] Municipal- and school-employee unions would, under Proposal 2, be empowered to negotiate clauses in their collective bargaining agreements that prevented emergency managers from altering union contracts, unilaterally or otherwise. The major material difference between Public Act 4 and Public Act 72 would thereby be nullified independent of voters' preferences on Proposal 1.
[*] The state's ability to amend a contract was set out in the New Deal era in the case Home Building & Loan Assn v Blaisdell, 290 US 398 (1934).
[†] Two of the governments with emergency managers — Highland Park schools and Muskegon Heights schools — may not have needed to exercise this power because of their move to "charterize" the districts — essentially turning the existing schools into charter schools that contract out the management of their operations. When charterizing the district, the current collective bargaining agreements do not cover employees working for the new charter firm. See Public Act 277 of 2011.
[‡] Terminal sick leave is a cash payment to an employee for unused paid sick leave when he or she retires.
[§] Longevity payments are additional that bonuses employees receive when they have served a specified number of years. The bonuses are in addition to the step increases in the uniform union salary schedule (see adjacent footnote).
[¶] Step increases are automatic additions to an employee's annual salary based on his or her length of employment. These increases are governed by a uniform union schedule.


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The perfect bat detector for passive monitoring.
The Elekon Batlogger A is a highly sensitive recording device (10-150kHz), with triggering functions and settings identical to all other Batlogger systems. This light-weight recorder (~600g) is easy to use, ensuring a trouble free operation.
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The Batlogger A uses standard AA batteries and records up to 30 hours (three 9hr nights).
We provide the Batlogger A complete with case, ultrasonic microphone with 2m waterproof cable, and 16GB SD memory card.


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Our Mission
The social and behavioral sciences (SBS) degree program integrates perspectives from psychology, sociology, and anthropology as it prepares students for careers in social services, mental health, law and public policy, early childhood care, and education.
Designed to enhance students' understanding of the psychosocial and cultural influences shaping individual lives and social institutions, the curriculum interweaves interdisciplinary courses in liberal arts (the LAC Common Core curriculum) with foundational SBS courses and a variety of courses providing more specific tools of the trade. Required courses such as Childhood and Society, Deviance and Social Control, and Applied Social Policy reinforce appreciation of the impact of societal influences. Students expand upon this knowledge through choices made from an extensive array of elective courses. Many students focus their choice of electives thematically, pursuing a Concentration in Counseling or in Public Health; a Concentration or Minor in Early Childhood Studies. Other students more fully customize their choice of electives (see link to degree Requirements) or integrate their SBS degree with related minors such asGlobal Studies, Leadership and Organizational Studies, or with a Certificate in Public Health or in Leadership and Organizational Studies.
Just as important to SBS degree study are service learning and field experience opportunities, which enable students to apply classroom learning in the field. The required sequence of Career Development courses, including the Internship, gives students opportunities to develop relevant skills while exploring professional opportunities firsthand – and often helps launch them in successful careers!
A range of students participate in the SBS program, from recent high school graduates exploring career options to seasoned professionals desiring additional education and career advancement. A variety of options exist for students interested in receiving credit for prior course credits, work experience, and performance on placement exams.
We also have transfer agreements for students who complete associate degrees in related fields, including students matriculating from Maine's Community Colleges. Students must complete 120 credit hours of coursework (which may include transfer credits) to complete the degree.


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With the New York Mets in San Francisco for a three-game series, one of the obvious story lines will be Matt Harvey "auditioning'' in front of Giants-National League manager Bruce Bochy to be the All-Star Game starter.
One of the best things about Harvey is his competitive drive, and his motivation isn't the All-Star Game as much as it is to be the best pitcher in the sport.
It wasn't too long ago his opposition tonight, Tim Lincecum, was considered the best. Not anymore. Here's a guy who last year was relegated to the bullpen for the World Series.
The reports on Lincecum is he's lost several mph., off this fastball, a pitch like Harvey's that was in the high 90s, and danced and darted within the strikezone. Lincecum does not have the same dominance and there are numerous theories, including the torque and violence of his delivery has sapped him.
Whatever it is, Harvey should be paying attention, for what he's experiencing now – from the cover of Sports Illustrated to dating a model to all the attention – is fleeting. It is the icing on the cake, but not the cake itself.
Harvey appears to have it all, which those around him say includes perspective and attitude. Harvey has nine no-decisions, including seven in games decided by three or fewer runs. Cut those in half to the positive and there shouldn't be any debate as to whether he starts next Tuesday at Citi Field. Harvey brushes them off with a "that's baseball," shrug.
The one thing we haven't seen from him is his reaction to true adversity. Not getting a few wins is one thing, but Harvey has not experienced losing his stuff, an injury or going on a long slide. He's not experienced what every great pitcher goes through. From Sandy Koufax to Greg Maddux to Roger Clemens to Pedro Martinez; they've all endured getting knocked around by the fickle nature of their sport.
It has been smooth sailing so fair, but it's never that way from beginning-to-end in a pitching career. So, when Harvey takes the mound tonight, it won't be about starting an All-Star Game, but maintaining a star status.
Harvey won't do it tonight because he's too focused, but in that 24-hour reflective window of his after, he will do himself well to look at Lincecum's career and understand the fragility of being the top dog.
Understanding it's not all cream, but at times sour milk, is vital when it comes to being the best. What Harvey has now is the foundation for a great career, but it is something never to be taken for granted.
Nobody understands that more than Lincecum.
As always, your comments are greatly appreciated and I will attempt to answer them. Please follow me on Twitter @jdelcos


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Taking on the 2014 DakarPosted in Events on May 13, 2014
The mere mention of the word Dakar causes widespread emotions among racers. Some become instantly excited at what, for many, is but a dream of competing in the absolute pinnacle of the off-road motorsports food chain. Others recall a nightmare of seemingly endless stages, huge distances, constant excessive heat, and long battles against sleep deprivation. A few racers may even break down and shed tears as they recall covering thousands of miles of brutal off-road terrain, only to be denied a finish tantalizingly close to the end.
The wealth of emotions the Dakar calls up is well deserved. It is more than a race. It is an epic, and even life-changing, adventure. The whole crazy idea started in 1977 when the late Thierry Sabine (who was later killed in a helicopter crash during the 1986 Dakar) became lost in the Tenere Desert while competing in the Abidjan-Nice Rally. Somehow, while wandering though this section of the vast Sahara desert, Sabine thought it would make the ideal location for rally.
Not one to muck about, Sabine put his thoughts into action, and the next year the inaugural Paris-Dakar Rally was held. Running from Paris, France, to Dakar, Senegal, it wasn't any typical rally, but rather the longest in the world—just over 6,000 miles. The crazy notion of racing for over two weeks across huge distances through Europe and Africa was an instant hit. By 1984, entries into race had crested over 400, and most European manufacturers had some kind of factory effort.
After terrorist threats became too big to ignore in 2008, the Paris-Dakar was cancelled and moved to South America for the 2009 running. While the move took the rally out of the remoteness of Africa and brought more of the creature comforts civilization entails, it is still absolutely brutal. In 2014, the Dakar competed over 13 stages and a total distance of 5,637 miles. As if that wasn't enough, the body that runs the Dakar (the ASO) thought the 2013 race might have been a bit too easy. In response, they created longer and more difficult stages that would push man and machine to their breaking points. It all makes the Baja 1000 look almost cute in comparison.
A Crash Course In Dakar
Among the 431 motorcycles, quads, cars, and trucks that entered this year's Dakar was a unique team of Americans brought together by the ASO's innovative Dakar Challenge program. Designed to increase both interest and participation in the rally from American racers, along with similar programs for Australia, South America, and Africa, the Dakar Challenge took the results from the 2013 HDRA Reno 500 and SCORE Baja 500 in Class 10, Class 7200, and Trophy-Truck with the fastest winning a free entry into the 2014 Dakar.
Ultimately, the Dakar Challenge was won by Peter Hajas in Class 10. However, after comprehending the massive task ahead of him, Hajas decided to team up with second-place finishers Jonathan and Jordan Brenthel of Brenthel Industries. For both Brenthel and Hajas, winning the Dakar Challenge program provided incentive to compete in the race and helped a bit with the cost. "We could not have made it there this year without the Dakar Challenge program. It pushed everyone over the edge and gave us the extra incentive to get everything done and get there," explains Jonathan.
Two factors quickly came into play. By the time the Dakar Challenge was won and Hajas and Brenthel decided to team up, the 2014 Dakar was only a few short months away. Secondly, after giving it lots of review and study, both Hajas and Brenthel decided modifying Hajas' existing Class 10 car wasn't feasible and wouldn't result in a competitive vehicle. A new vehicle was designed and built in an amazing 45 days, before it was briefly tested and stuffed into a shipping container for the long and slow boat ride to Valparaiso, Chile. Once there, the Brenthels drove the racecar (not towed) on the highway the 800 miles to Rosario, Argentina for the start of the 2014 Dakar.
A Harsh Reality
The start of the rally in Rosario, Argentina, is an overwhelming experience and like nothing I have ever seen. According to Rosario city officials, over 1,000,000 people would show up to take part in the podium celebration kicking off the beginning of the Dakar. Each and every motorcycle, quad, car, and truck is rolled onto a podium, and the driver is briefly interviewed in front the constantly cheering Argentinian crowd. If you thought the motorsports fans in Mexico were fanatical, you haven't seen anything yet.
Even more overwhelming for the extremely small and shoestring budget team of Americans was what lay ahead of them. Jonathan Brenthel put it all into shocking perspective. "Racing the Dakar is like racing the equivalent to two full seasons of racing every SCORE and BITD desert race there is." When thought of in this light, it was indeed staggering, especially for a quickly formed rookie team (rookie to Dakar, at least) with a brand-new racecar.
Almost immediately, the team ran into problems. The oppressive triple-digit Argentinian heat plagued their racer with fueling and cooling issues. Peter Hajas and co-driver Kevin Selchow had to continually stop during the first day to try to figure out the issue and finished well back in the order.
On the second day, the problems continued to slow their progress and forced the duo into the sketchy gray dunes of Nihuil at night. Both thought it would be wise to wait until morning, as navigating through the dunes at night is close to impossible, (Remember, there are no GPS units allowed in the Dakar). However, a broken alternator eventually ended their Dakar the following morning. With no chase trucks allowed to pop into the course and deliver parts, the Brenthel/Hajas effort was officially over on Stage 2.
They were not alone in their misery. Every team from the United States that had entered also encountered fueling issues on the first few stages, pushing them way back into the order. Both Robby Gordon's and BJ Baldwin's crews were hard at work trying to solve the issues. Eventually, it seemed they did, but neither would see the finish line. Robby Gordon eventually retired on Stage 11 only two days from the finish. BJ Baldwin went out on Stage 10. Only the El Martillo Racing team from Canada and Mexico were left to represent America, finishing 52nd with their Jimco-built Dodge Durango.
The Monster MINI Machine
In stark contrast to the American efforts was the extremely well funded and well oiled machine that is the Monster Energy X-raid MINI team. This year, the team fielded a jaw-dropping 11 MINIs, featuring some of the best off-road racers in the world. Included among them were Stephane Peterhansel, Nani Roma, and late addition to the team Nasser Al-Attiyah. All are Dakar veterans who have competed in the rally for years and Peterhansel holds the record for wins with a staggering 11 overall Dakar victories.
To many, it was no surprise when MINI absolutely dominated the Dakar, taking the top three spots with Roma first, Peterhansel second, and Al-Attiyah third. In fact, seven out of the top 10 spots went to MINI. The only controversy happened when Peterhansel was ordered to allow Nani Roma to take the win and slowed his pursuit of Roma allowing him to get to the checkers first.
Some think of the MINI team as a new team with almost unlimited funds that can basically outspend any other team and buy a win. But this is not completely true. Yes, the team is extremely well funded and can bring vast resources to take on Dakar, but it is also one of the most experienced. That experience goes beyond the drivers, too. The head of the X-raid team, Sven Quandt, started racing in the Dakar 1998. He was the head of Mitsubishi Motor Sports' massive Dakar team from 2002 until X-raid was formed. He knows how to run a team and picked some of the best mechanics, logistical minds, and Dakar specialists to come to X-raid upon its formation.
Beyond that, Quant and the X-raid team field what is an extremely reliable MINI racecar. All 11 entered in the 2014 Dakar finished, a remarkable achievement—over a mind-blowing 62,000 miles of total distance raced for all of X-raid's racecars. The MINI team also does several rallies throughout the year to test components and drivers, as well as take other wins. By the time they show up at Dakar, they have thousands of test miles on them and are thoroughly sorted.
Lessons Learned
For Jonathan and Jordan Brenthel, their experience at Dakar provided plenty of lessons. "Knowing what we know now, we wouldn't go back without more prep time, more training, and more testing. If you look at every American team over there, we all had the same issues because when we go testing, we want to test in a wonderful 70 degrees when everything is all fine and dandy. We need to be doing it in the middle of July at Glamis when it is 120 degrees out to imitate what we will be seeing at Dakar. It has to be done a lot sooner, and we need a lot more time to prepare for it properly," shared Jonathan.
Another harsh lesson was the lack of an assistance vehicle. In sharp contrast to American desert racing, there are no pits along the course and chase vehicles going onto the course to rescue broken or stranded racers is prohibited. Only other vehicles, such as the huge Tatra and Hino 6x6s in the truck class, entered in the race can provide assistance. "The number one thing we missed was having on-course support," shares Jordan. "We didn't realize how crucial that was and frankly didn't have the budget for it. If we had on-course support, we would have gotten through who knows how many days, but considerably more. It would have been a huge help."
Budget was also another major factor. "I would never go back to Dakar without the right amount of money. That is definitely what it boils down to," says Jonathan. So how much does a smaller Dakar effort cost? The answer was truly staggering. "For leasing an assistance vehicle with a crew and all your tools and parts on it, the cost is $100,000. You can split that between other teams, but the truck won't be completely dedicated to you then. If you had to pay to build a secondary chase truck to haul your crew and more parts, that is about another $100,000. A racecar like ours would start at $200,000 and run up to $300,000 for a very nicely equipped one. We had around $70,000 in ASO fees and that was with a small crew. Our shipping costs were $30,000." Obviously, Dakar is not for the faint of wallet, but there are teams that do it for cheaper with the hope of just finishing and in a much lower-performance car.
Beyond the machine and the money are the all-important driver and navigator. "Even if you are an experienced desert racer here in the States, you really need to have a lot of training before you go down there," commented Jordan. "The co-driver is just as important, if not more so, than the driver. His navigation skills are vital, and he really needs to know a lot of the intricacies of the many rules of the rally. Ideally, he is someone who has already done the rally."
The Challenge Continues
Will an American ever win Dakar? As more Americans become interested in it, the opportunities for bigger sponsorship will rise. That in turn, will allow more American teams to enter the race and gain valuable experience like that learned by Brenthel Racing. All of it will help to move closer to the goal of an American eventually coming out top at Dakar.
To help keep interest rising among American races, the ASO will continue its Dakar Challenge for 2014. This year, the winners will be determined solely by the SCORE Baja 500 in Class 10, Class 1, and Trophy-Truck along with motorcycles. Whoever wins it will gain a free entry to the Dakar—the toughest race on the planet. They better be ready with extreme dedication and plenty of resources if they want to even finish it, much less win.


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For the main characters, do you think you can use the character profiles Miura has drawn in recent volumes?
Volume 27 cover for Guts. It better be definitive. I got it tattooed on me.
For one of Guts i could think of a picture of him grinning. To me that's something I notice he often before or during a fight, I dunno I've always found it nice when he does that.
Got a particular one in mind?
The image I'm leaning toward right now is similar to Volume 17's, which unfortunately doesn't have the characteristics of a portrait due to the lettering, Puck's placement and the fact that it's a very stylized painting. I'm looking for something that captures the character, while also being representational of how you'd normally see this character.Here's what I'm thinking:
I wouldn't use that one, honestly. It makes it seem that Guts is altruistic, which he isn't.
I don't have all my volumes on me since I lent volumes past 27 to a friend. Those inserts/ posters that come with each volume have anything you can use perhaps?
So far all the suggestions have been volume covers and posters. For the main characters we can suggest black and white correct? Would you perfer the central cast to all be Miura colorings? It might seem off to have Guts and Griffith in color, while Casca is in black and white.
I suggest Casca under the Band of the Hawk flag after taking "Dorwey Castle" is it? Casca being held up by her company.
I was thinking this for Guts. He has that caring look as he is looking at Casca, but at the same time for those who know the pic he just has managed to kill those possessed heretics.
I was thinking: Which I think works particularly well since it's Guts own image of Casca. Unless there are color versions of Casca that work better, of course.
I like the ones people have posted so far!I'll contribute with some other ones I think are good too:
Carcus: I don't think a smiling picture of Carcus is definitive for him. A scowl maybe. There is another color illustration by Miura that works a little better I think.
Farnese: I actually prefer the one in the inside corner of Volume 24: http://www.skullknight.net/encyclopedia/world/characters/farnese_small.jpg Mostly because it's not as contextual as the one of her next to a fire
Griffith: I prefer the one I chose earlier. Similar to what a member said of Guts earlier, I think the one you've chosen looks a little too altruistic. The look on his face doesn't convey all that it could about Griffith's character.
Isidro: This might be the best choice. What do you think of this though? http://www.skullknight.net/encyclopedia/world/characters/isidro_small.jpg
Jill: I wonder if a black and white illustration would be best. This one hardly resembles the Jill I know.
Luca: Maybe. Though in color, I don't think it captures her well.Nina: Same as above.
Pippin: It's a toss up between this and http://www.skullknight.net/encyclopedia/world/characters/pippin_small.jpg for me
Puck: I... will probably choose this one. But that image always makes me a little uncomfortable. Just such a gross, un-Puck like expression.
Schierke: This one really captures her well. My first choice was this though: http://www.skullknight.net/encyclopedia/world/characters/schierke_small.jpg
Serpico: I think this one's a little too uncharacteristically cool to define Serpico.
Zodd: I prefer http://www.skullknight.net/encyclopedia/world/characters/zodd.jpg for the emotion that it captures for Zodd.


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Howdy All
Snowshoed from the tram to San Jacinto yesterday with seven friends -- Cameron, Marilyn, Sally, Mari (Sally's sister), Larry, Kalen, Robin. Thanks to those who broke in the route in the forest up to 10 K, we were able to take the modified winter route (Sid Davis > Tamarack > upper Tamarack > 10 K (big bend where trail passes Jean's gully and heads up to the Miller switchback) > Boy Scout route > peak.
To be honest, I followed the wrong snowshoe track and lost the route shortly after Sid Davis I was too far south and we had to go up and over a ridge to reach lower Tamarack. Cameron was in front and took Sid Davis to Tamarack. Compared to Christmas day, it was quite warm. When we reached Big Bend (10 K), I headed up the gully known as "Jean's Crotch" to the ridge and headed to San Jacinto.
Finally on the ridge after climbing up 'Jean's Crotch."
Looking towards Jean peak after reaching the ridge.
Rime ice on the ridge.
My friends went up the trail to Miller's Saddle and then took the Boy Scout route to the peak. When I reached the junction sign, I realized that my snowshoes were picking up new, sticky snow. It felt like I had cement on the bottom on my snowshoes. I had to stop periodically and bang my feet against trees/rocks to shed the snow.
As I was approaching the peak, Sally called out. We enjoyed lunch on San Jacinto before heading down (Sally's photo).
View of San Gorgonio from the peak (Sally's photo).
View towards Santa Rosa wilderness.
View towards Jean from the hut.
As we descended the Boy Scout route, Hiker Hal and his son were ascending. This is the first time I've actually met Hal, who I consider a dear friend even though this is the first time I've had the honor of meeting him.
Heading down to Tamarack.
Back at the tram. we enjoyed celebratory beverages before getting in line to head down.
Miles of smiles,


text:
March 30, 2007
In their first home game in a month, the Bisons were defeated 5-2 by the North Florida Ospreys on Friday, March 30.
After falling behind 1-0, the Bisons took the lead in the bottom of the second. Ryan Wilkins led off with a single before advancing to second on a single by Casey Bond. Branden Cadavid followed with a ground out to first, setting up Shane Simpkins to drive in both runners with a double to left center.
The Ospreys added two runs of their own in the fifth and a run in the ninth to take a 5-2 lead, which would be the final.
John King recorded the loss to drop his record to 0-3. In four innings, he gave up four runs, three earned, on five hits, while striking out one.
King was relieved by right-hander, Brandon McClurg, with runners on second and third in the sixth. McClurg escaped the jam, allowing only a run, which was charged to King. In five innings, McClurg gave up just one unearned run on three hits.
On the season, Mcclurg is 2-1 with a 2.58 ERA. He has struck out 35 and opponents are batting just .194 against him.
The Bisons are back in action tomorrow, Saturday, March 31, when they take on North Florida in a double-header. Game one is set to kick off at 1 p.m.
Left-hander, Rex Brothers, will make the game one start for the Bisons. On the season, Brothers is 4-1 with a 4.89 ERA. In 35 innings, he has given up 19 earned runs on 27 hits, while striking out 35. Opponents are batting just .220 against him.
For the Ospreys in game one will be right-hander Derek Bell. On the season, Bell is 1-0 with a 4.82 ERA. In 28 innings, he has given up 25 runs, 15 earned, on 36 hits, while striking out 23. Opponents are batting .305 against him.
The Bisons will send right-hander, Rob Smithson, to the mound in game two. Smithson is 3-2 with a 3.15 ERA. In 40 innings, he has given up just 14 earned runs. He has struck out a team-leading 41, and opponents are batting just .209 against him.
The Ospreys will throw left-hander, John Atteo, in game two. On the season, Atteo is 2-2 with a 5.87 ERA. In 38.1 innings, he has given up 27 runs, 25 earned, on 50 hits, while striking out 25. Opponents are batting .314 against him.
Following the three game conference series against North Florida, the Bisons will host Tennessee-Martin at Dugan Field on Tuesday, April 3, in a game set to begin at 6 p.m.


text:
Carrie Prejean
Carrie Prejean was a contestant representing California for the 2009 Miss USA Pageant, of which she was the runner-up. Prejean created a media firestorm with her response to radically liberal, ultra-gay video blogger and Miss USA judge Perez Hilton's question about the legalization of gay marriage.
Perez Hilton: "Vermont recently became the fourth state to legalize same-sex marriage. Do you think every state should follow suit?"
Carrie Prejean: "I think it's great that Americans are able to choose one or the other. We live in a land that you can choose same-sex marriage or opposite marriage and, you know what, in my country and my family I think that I believe that a marriage should be between a man and a woman. No offense to anyone out there but that's how I was raised and that's how I think it should be between a man and a woman."
In response, many members of the audience cheered or booed. Hilton predictably disliked the answer and attacked her publicly on his blog, stating, "She gave the worst answer in pageant history. She got booed. I think that was the first time in Miss USA ever that a contestant has been booed. She lost not because she doesn't believe in gay marriage. Miss California lost because she's a dumb b****, OK?" Hilton issued a half-hearted apology, but later went on national TV to rescind his apology and to say that he said the "b-word," but was actually thinking the "c-word."
Prejean quickly became a media sensation, appearing on many news programs and talk shows. She staunchly defended her views, once stating, "I have no regrets about answering honestly. He asked me for my opinion and I gave it to him. I have nothing against gay people and I didn't mean to offend anyone in my answer."[1]
Judge Perez Hilton
The question presented to Prejean was written by Mario Lavandeira, also known as Perez Hilton, who said, "I ran it by the producers beforehand and they signed off on it and everybody thought it was a good question." In his interview with Larry King, Hilton further said, "...she knew she had lost because of that answer because it was a bad answer." King responded, "Why is it bad if it was honest?" Hilton's liberal reply was, "Honesty is great. However, in an interview this morning, she said that the audience and the judges expected her to be politically correct. You want to know what? Yes. I do expect Miss USA to be politically correct." [2]
Absence of Rights Groups
The ACLU, so-called free speech defenders has offered no defense of Prejean's freedom of conscience. The National Organization of Women is absent from defending Prejean against hate speech attacks directed torward her. It is the double standard by liberals and their leftwing agenda, who fear conservatives and traditional values.
Liberal backlash and aftermath
Liberals across the board began a vicious campaign of character assassination against Prejean because she dared use her First Amendment rights in a manner they found unfit. MSNBC's Keith Olbermann and gay columnist for the Village Voice Michael Musto leveled extremely mean-spirited barbs at Prejean on "Countdown with Keith Olbermann."[3]
An anonymous source also leaked controversial photos of a 17-year-old Prejean to the celebrity gossip website TMZ in an attempt to cost her her title as Miss California and discredit her as a supporter of traditional marriage.[4] However, in response to the attacks, Donald Trump, owner of the Miss USA Pageant, backed Prejean and allowed her to retain her crown.[5] In his statement, Trump pointed out that even President Obama and Hillary Clinton share the same opinion on marriage as Prejean. He also revealed that Perez Hilton (referred to as "Judge #8") gave Prejean very low scores, but Trump stated that it did not cost her the Miss USA crown, contrary to Hilton's claims.[6]
An emotional Prejean responded to her critics, stating:[7]
"I am a Christian, and I am a model. Models pose for pictures, including lingerie and swimwear photos. Recently, photos taken of me as a teenager have been released surreptitiously to a tabloid website that openly mocks me for my Christian faith. I am not perfect, and I will never claim to be, but these attacks on me and others who speak in defense of traditional marriage are intolerant and offensive. While we may not agree on every issue, we should show respect for others' opinions and not try to silence them through vicious and mean-spirited attacks."
Unsurprisingly, the attacks against Prejean continued in response.[8]
- ↑ http://www.myfoxal.com/dpp/news/dpgo_miss_california_perez_hilton_lwf_0420092424645
- ↑ http://www.cnnstudentnews.cnn.com/TRANSCRIPTS/0904/20/lkl.01.html CNN, April 20, 2009
- ↑ http://newsbusters.org/blogs/brad-wilmouth/2009/05/06/olbermann-guest-likens-miss-california-nazi-doll-makes-crude-sexual-j
- ↑ http://www.foxnews.com/story/0,2933,519796,00.html
- ↑ http://www.lehighvalleylive.com/entertainment-general/index.ssf/2009/05/donald_trump_to_decide_fate_of.html
- ↑ http://abcnews.go.com/Entertainment/Television/story?id=7516983&page=1
- ↑ http://www.cnn.com/2009/SHOWBIZ/05/08/ent.miss.california.usa/
- ↑ http://www.msnbc.msn.com/id/3036677/#30711675


text:
Smells like fish. Miami Rail Jam
Yan Thebolt from the waterline
Monday night football in Miami, Jimmy Buffet, a giant Dan Marino-bobblehead walking around, combined with two asphalt-parked pools and killer wakeboarding? When the Rail Jam invaded the Miami Dolphin's season opener against the Indianapolis Colts at Landshark Stadium, football fans didn't know what to think!
Spectators surrounded the event, which included two above ground pools, 50 feet of gnarly rails and a kicker, with a slew of insane riders pulling sky-high tricks. Top riders such as Brian Grubb, JD Webb, Shawn Watson, Erik Ruck and Ross Gardner threw down for Dolphin fans for over 4 hours!
The Miami Dolphin mascot threw football passes as riders attempted mid-air interceptions. The riders changed up boards and skates while serving up airs, slides, rails and spins. Shawn Watson even pulled off a successful railslide-cellphone call without drowning out the lucky recipient. All in all the rail jam went out without a hitch and riled up Miami and Colts fans got a killer pre-game show.
The party finally wrapped up as hummers and limos dropped off celebrities at the poolside red carpet. Hopefully the riders got to catch the game before heading back out on the road to bring the Step Up Rail Jam Tour to its next stop…
By Stephanie LaVigne and Ben Hicks
TagsPhotos ross gardner brian grubb shawn watson erik ruck Article JD Webb Landshark Stadium Step Up Rail Jam Ben Hicks Stephanie LaVigne
Hey guys, thanks so much for coming down. These shots are epic and I cannot tell you how great the response was from the crowd!! Thanks to all the riders once again 🙂 Aloha
Hey Ben and Stephanie
Great photos! No photos with Grubby and the Dolphin Cheerleaders?!
Go Fins!!!


text:
Breaking News
Congress might be shut down ... but President Barack Obama found time to dive into the debate over the Washington Redskins name -- telling a reporter he would "think about changing" the team name because it offends people.
The Prez was asked about the issues renewed controversy over the past few months ... and proclaimed nostalgia isn't a good enough reason to keep the name.
Saying if he were team owner ... there'd be serious discussion about changing it.
However, Barack doesn't think fans of the name are being racist -- they're just passionate for team history.
Obama joins a growing movement of people once again pushing for the change -- including NFL commissioner Roger Goodell.
Name change or not ... the Redskins still suck this season.


text: The Iowa Department of Natural Resources is asking southeast Iowa farmers and landowners to enroll unused portions of their land to the Conservation Reserve Program that begins Monday. Iowa Farm Service Agency Director John Whitaker says the program has increased its rental rates, "making CRP a more attractive alternative" than before. Whitaker says high costs and low yields can make renting land to the Conservation Reserve Program the best option for farmers to get the highest return per acre, but it's important to plan now. The last general signup for the program was in 2006, and participation is limited. For more information, contact the Iowa Department of Natural Resources.


text:
Combine a herringbone pattern with the popular zig zag for a fun, unique pot holder and trivet that is self binding. Or use the blocks to make a quilt! Great for Christmas gifts, teacher gifts and using up extra charm packs!
- 1 Simply Color charm pack or charm pack of your choice
- 1 yard of fabric for backing or four 14×14 inch squares
- 1/2 yard batting or eight 10×10 inch squares
- 1/2 yard insul-bright Insulating material or four 10×10 inch squares
I'm so excited to be here! I've been making these hot pads like crazy! You can hop over to my blog, Melanie Dramatic, to see several other examples in various Moda lines along with a few other ideas of what you can do with this design!
You'll start with one charm pack! (I cut down a layer cake to 5-inch squares since that's what I had!)
Cut your charm pack into 1 1/2 inch strips. From one charm pack you'll get 3 'sets' of strips.
Now it's time to start sewing strips together using a 1/4 inch seam.
Alternating sides, continue to add strips. (I finger press the seams down toward the bottom of the 'V' as I sew….although getting up to iron each seam during the process would be better exercise…)
Continue sewing until your first stack is gone! You'll have a really fun, colorful, long herringbone strip!
Iron the seams down (toward the bottom of the 'V').
Square the top and cut two 11-inch sections. (You will have left over. Save that to start sewing your next strip set.) Our hot pads will be 10 inches, but that little bit of extra length allows you to perfectly match seams.
Next you will trim off the extra on each side. You want each rectangle to be 5 1/2 inches x 11 inches. I match up the 2 1/2 inch mark on my ruler with the bottom/right 'V' for the first cut. Then I rotate and cut the block to 5 1/2 inches width.
Pin your rectangles together at each seam. Seams will all face down. Do not worry about lining up the top and bottom. Getting the seams to mach is more important! Sew together with a 3/8 inch seam allowance.
Press center seam allowance open.
Trim your block to 10 inches x 10 inches.
You'll need one 14x14inch piece of fabric for the back, two 10×10 inch squares of batting and one 10×10 inch square of Insul-bright insulation. It is a lot of layers, but I really like the extra sturdy feel this gives the hot pad – plus with the Insul-bright and extra batting, I'm not afraid to pull something out of the oven! (If you're going to use it solely for decoration, you could use one or two layers of batting only.)
Place the Insul-bright in between the two layers of batting and pin all layers together. Spray basting also works well to hold everything in place.
Quilt as desired. I love the look of following the seams with my 1/4 inch foot.
Carefully even batting and top layers ONLY if needed with scissors. Next cut off the excess backing fabric so it is 1-inch larger than the top on each side. The unit will measure 12×12.
Fold and iron the extra inch of backing fabric in half so that it meets up with the raw edge of your hot pad. Then fold again to the top of the hot pad and secure in place. (I was using bobby pins at this point but my new favorite method is using school glue to hold fabric in place. Simply set with a hot dry iron!)
Fold your corner diagonally so that it meets with the raw edge of the next side. Then continue by folding that edge in half and then again up onto the hot pad, just as you did on the first side. Continue working your way around the hot pad until all four sides are ready to sew.
Sew binding in place. Get your stitching as close to the inside edge of the binding as you can. And if you're using bobby pins or other gadgets to hold the binding in place, please be sure to remove them as you sew! (If you switch to glue, you won't have to worry about that anymore!)
One charm pack will make four hot pads. (Use your left over strip to start sewing another set for more hot pads!) And don't forget to come over to my blog to see them made in other Moda fabrics and a few other projects I've made with these fun blocks! I have to say, I'm sorta in love with the quilt. 🙂


text:
Chickendale 2013
Calendar January 2013 (12 Months)
Price: $17.49
Prints in 3-5 business days
This calendar is of the roosters of Poplar Spring Animal Sanctuary, and each month's image includes their name. Any profits from the sale of this calendar will be donated to the sanctuary. Poplar Spring Animal Sanctuary is a 501(c)3 non-profit organization. It is run entirely by donations from the public and does not receive any county, state, or federal funding. Donations go directly to help feed and care for the animals, and are fully tax-deductible as allowed by law.
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Product Details
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- January 2013
- Calendar Length
- 12 Months
- Format
- Standard Calendar
- Language
- English
- Product ID
- 20368724
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text:
Xbox One gives you the ability to set a personal passkey. The six-character passkey offers the following benefits:
Note Passkeys will not follow you to an Xbox 360 console. To learn more about parental controls on Xbox 360, see Set parental controls for Xbox 360.
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text:
If you showed up today expecting recipe number two from Italian Week, I apologize. It was supposed to be pasta e fagioli (pasta and bean soup), but I totally botched it! Remember how I said I used to be known for one kitchen disaster with every meal? Last night's disaster was forgetting that pasta e fagioli is supposed to have tomato in it. And forgetting that soup in general usually needs an acid in order to not suck! It actually didn't suck, but without the tomato to brighten it up, the pictures looked really drab. So it's not front-page blog material, at least not until I'm really hurting for content.
Ignore Nutrition Facts, Read the Ingredients List
What I want to write about instead is nutrition facts. And the lack thereof on my blog. I read a Twitter post yesterday by someone complaining about health sites that don't post nutrition facts. It would be naive for me to believe that my blog prompted this complaint, but my first thought upon reading this was I need to start doing that in order to make sure every last reader is satisfied.
But something about that felt wrong. I write this blog to share the way I eat and exercise, because eating delicious food and staying healthy is one aspect of life that I think I'm great at. And I'm not too modest to say that. I'm not a raw-food vegan, and I'm certainly not the fastest marathoner. But I think my version of a healthy, active life filled with delicious food is one that regular folks can adopt as their lifestyle, not just a diet.
I almost never look at nutrition facts. If we were meant to read nutrition facts, then whoever created this world would have put nutrition labels on food. And in a way, he/she/it kind of did, only not in the form of a list of numbers. If a food is ripe and good for us, then it usually looks fresh, vibrant, appealing, and real. That's the only nutrition fact you need. Obviously there are exceptions, but you get the idea. Eat real foods, eat colorful foods, eat local foods, eat a variety of foods, the way you are meant to and the way people did for thousands of years until this hip new thing called technology came along and screwed it up.
Eating isn't supposed to require math. If every time you eat, you have to add up a bunch of numbers and worry about how many of your allotted calories you're using up, then you're doing it all wrong. You're supposed to enjoy eating. I'm not one of the "thoughts are things" New-Agers, but I do believe that if you feel guilty everytime you eat, then you're sending the your body the wrong message. Food tastes good to us because calories are fuel. Fat tastes especially good because it's nourishing and used to be scarce. When you avoid fats and calories, you send your metabolic system the message that it's a time of famine, and your body responds by storing away whatever it can find, usually in the form of that nice Goodyear inner-tube around your midsection.
Here's how to decide what to eat. Check the list of ingredients in a food. Best case: one. An apple contains… surprise, apple! Certainly we have to combine lots of foods when we cook, but the difference between cooking and buying prepared foods is that we're the ones doing the combining. We don't add preservatives for shelf life, and we don't add cheap fake flavors to turn a bigger profit. If you need to buy something prepared, just make sure it doesn't have many ingredients, and make sure you can pronounce all of them. As you can tell, this method requires a lot of very complex calculations, but we are very lucky to be living in an age of technology so we can carry them out to a high degree of accuracy.
So that's why I don't care about nutrition labels. If you find yourself using a certain ingredient a lot, then sure, check the nutrition label to make sure there aren't any shockers. But most of the time, screw that. The caveat is this: eating the way we are meant to requires living the way we are meant to. Specifically, doing things. We used to have to hunt for food or spend hours in the fields to grow food. Everyone knows we aren't designed to sit at a computer all day writing a blog article about nutrition facts that's growing longer than we planned. So you have to move around if you don't want to get fat. It's very complicated, this nature thing, but you'll get the hang of it.
I look forward to your comments about this philosophy. I have a feeling this post might earn me my first haters! All I can say is that I didn't invent it. Actually it's old; in fact I think the 1.2 million year anniversary of its invention is coming up next month.
A final warning: If you're already way overweight, then my advice might not be right for you yet. You probably need a big calorie reduction and exercise, all done safely of course. Once that's taken care of, then you can start ignoring nutrition labels. If you stay active.


text:
An exclusive coming from BGR from their sources is that RIM is planning to bring BlackBerry Messenger app and service to the Android and iOS. This means that Tablets from Google's Android OS and Apple's iOS will be running BBM as well. Sources report that RIM has not yet finalized details surrounding timing or pricing, and might make the software free to all users. Strategy is still being developed, and RIM may end up charging users a one-time fee or even a recurring fee for access to its BBM service on third-party platforms.
As far as what Android and iOS users can look forward to, well, sources say that RIM will offer stripped down versions of the BBM which means that the potential for millions more users will be able to communicate cross-platform via BlackBerry Messenger. But depending on the limits that RIM puts on a simplified version, they might not be able to share photos, location, or videos, ect. Users who want the full BlackBerry Messenger experience will still need a BlackBerry. BGR also reports:
Would bringing BBM to devices other than BlackBerry pull you away from RIM, or bring you closer? Vote on our poll above this thread and leave a comment and tell us why.Right now, we have heard that Android is definitely a go. But again, we're not sure on timing, though our sources are confident that it will launch some time this year. RIM chose Android first because of the fact that it could develop and integrate something like this much easier with an open platform, but the plan is to build and deploy an iOS version at some point as well.


text:
Investigate Safety, Pharmacokinetics and Pharmacodynamics of GSK2118436 & GSK1120212
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT01072175
Recruitment Status : Completed
First Posted : February 19, 2010
Results First Posted : November 21, 2013
Last Update Posted : November 26, 2018
- Study Details
- Tabular View
- Study Results
- Disclaimer
- How to Read a Study Record
|Tracking Information
|First Submitted Date ICMJE
|February 12, 2010
|First Posted Date ICMJE
|February 19, 2010
|Results First Submitted Date
|June 27, 2013
|Results First Posted Date
|November 21, 2013
|Last Update Posted Date
|November 26, 2018
|Actual Study Start Date ICMJE
|March 26, 2010
|Actual Primary Completion Date
|May 31, 2012 (Final data collection date for primary outcome measure)
|Current Primary Outcome Measures ICMJE
|Original Primary Outcome Measures ICMJE
|Change History
|Complete list of historical versions of study NCT01072175 on ClinicalTrials.gov Archive Site
|Current Secondary Outcome Measures ICMJE
|Original Secondary Outcome Measures ICMJE
|Current Other Outcome Measures ICMJE
|Not Provided
|Original Other Outcome Measures ICMJE
|Not Provided
|Descriptive Information
|Brief Title ICMJE
|Investigate Safety, Pharmacokinetics and Pharmacodynamics of GSK2118436 & GSK1120212
|Official Title ICMJE
|An Open-Label, Dose-Escalation, Phase I/II Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics and Clinical Activity of the BRAF Inhibitor GSK2118436 in Combination With the MEK Inhibitor GSK1120212 in Subjects With BRAF Mutant Metastatic Melanoma
|Brief Summary
|This is an open-label, dose escalation study to investigate the safety, pharmacokinetics, pharmacodynamics and clinical activity of GSK2118436 and GSK1120212 in combination. This study is designed in four parts. In Part A, the effect of repeat doses of GSK1120212 on the pharmacokinetics of single dose GSK2118436, will be investigated prior to evaluating combination regimens. In Part B, the range of tolerated dose combinations will be identified using a dose-escalation procedure. In Part C, different dose combinations of GSK2118436 and GSK1120212 will be evaluated, based on results from the dose escalation cohorts. In Part D, the pharmacokinetics and safety of GSK2118436 administered as HPMC capsules alone and in combination with GSK1120212 will be evaluated.
|Detailed Description
During Part A, a cohort of subjects will receive a single dose of GSK2118436 alone (Day 1) and then repeat doses of GSK1120212 for (Day 2 through Day 15). The dose regimen of GSK1120212 will be continuous dosing. A second single dose of GSK2118436 will be administered on Day 15 concomitantly with GSK1120212. Day 16 through Day 28 will be a washout period, during which no study medication is administered. Starting on Day 29, subjects who elect to continue participation in the study will dose with GSK2118436. The dose of GSK2118436 after Day 29 may be altered based on emerging data from the first-time-in human study BRF112680. The dose may be increased to a dose level that has been completed and determined to be less than or equal to the maximum tolerated dose in that study.
Part B of the study will enroll cohorts in escalating doses to identify a set of allowable doses to be expanded in Part C. Subjects will enrolled in a 3+3 cohort design, with provisional dose levels of both drugs. The decision regarding escalation to the next dose levels of GSK1120212 and GSK2118436 will be further guided by a Bayesian logistic regression model. The first cohort will start at low doses for both drugs. Doses up to 300 mg/day for GSK2118436 and up to 3 mg QD for GSK1120212 have been studied to date. The starting dose may be lowered based on emerging data from other studies and from Part A.
Expansion cohorts will be enrolled in Part C at dose levels of GSK2118436 and GSK1120212 as defined in Part B. One of the selected doses may include GSK2118436 administered as monotherapy at a tolerable dose (less than or equal to the maximum tolerated dose) determined in BRF112680. Part C is a randomized open-label Phase II portion of the study, and will consist of expansion cohorts investigating 2 to 3 dose levels of GSK2118436 and GSK1120212 dosing in combination, and GSK2118436 administered as monotherapy. Subjects will be assigned to treatment arms in a randomized fashion to compare tolerability and safety. Population PK parameters, clinical activity, durability of response and safety of GSK2118436 and GSK1120212 dosed orally in combination and GSK2118436 as monotherapy will be evaluated.
Part D will consist of evaluation of the pharmacokinetics of GSK2118436 HPMC capsules administered as monotherapy and in combination with GSK1120212. Pharmacokinetics of GSK2118436 will be assessed following a single dose on Day 1 and after repeat dosing (Day 21) and compared between combination and monotherapy. The pharmacokinetics of GSK1120212 will also be assessed. Safety, tolerability and clinical activity will also be evaluated in 4 dosing cohorts. These cohorts may be expanded for additional safety data. Subjects will be randomized to different cohorts.
|Study Type ICMJE
|Study Phase
|Phase 2
|Study Design ICMJE
|Allocation: Non-Randomized
Masking: None (Open Label)
Primary Purpose: Treatment
|Condition ICMJE
|Intervention ICMJE
|Study Arms
|Publications *
* Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
|Recruitment Information
|Recruitment Status ICMJE
|Actual Enrollment ICMJE
|Original Estimated Enrollment ICMJE
|Actual Study Completion Date
|February 27, 2018
|Actual Primary Completion Date
|May 31, 2012 (Final data collection date for primary outcome measure)
|Eligibility Criteria ICMJE
Inclusion Criteria:
Exclusion Criteria:
|18 Years and older (Adult, Older Adult)
|Accepts Healthy Volunteers
|Contacts ICMJE
|Contact information is only displayed when the study is recruiting subjects
|Listed Location Countries ICMJE
|Australia, United States
|Removed Location Countries
|Administrative Information
|NCT Number ICMJE
|Other Study ID Numbers ICMJE
|Has Data Monitoring Committee
|U.S. FDA-regulated Product
|IPD Sharing Statement
|Not Provided
|Responsible Party
|Novartis ( Novartis Pharmaceuticals )
|Study Sponsor ICMJE
|Novartis Pharmaceuticals
|Collaborators ICMJE
|Not Provided
|Investigators ICMJE
|PRS Account
|Verification Date
|November 2018
ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP


text:
Kenny Chesney Wraps Rehearsals for Brothers of the Sun Tour
With just weeks until the launch of his Brothers of the Sun Tour with pal Tim McGraw, Kenny Chesney has wrapped rehearsals for the all-arena outing. The country entertainer feels confident and prepared to take the stage show on the road, and admits the tour has been anything but a rushed project.
"We hadn't even finished last year's tour when we started working on this year, and what we visualized nine months ago is a reality today," Chesney shares proudly (quote via Sony Music Nashville).
Rehearsals aside, Chesney understands the importance of remaining in spectacular physical shape with such a demanding schedule. In a recent interview with Men's Health magazine, the 44-year-old singer talks about the strict regiment that keeps him trim and toned. "I've never abused my body with drugs," Chesney admits. "I've never smoked. But I will say that I've probably been overserved a lot. You can't spend 19 years on the road and not have a few drinks."
Spirits aside, the singer never picks up the salt shaker — at least in the past 10 years — and hasn't even had bread "in a while."
"You think you're sprinting on this treadmill," says Chesney, talking about his high-energy stage shows. "When I'm up there it's like I'm at a constant sprint at a 15 level. But the thing you have onstage that you don't have in the gym is adrenaline."
With all the lighting and visuals timed perfectly — and all final tweaks made — an enthusiastic Chesney is ready to kick the party off the right way. "It's the fans that make this all happen and we're ready to let this show loose on you," says the 'Come Over' singer."We've rehearsed and our bags are packed, so get your tailgating ready and we'll see you in the parking lots and in the stadiums all summer long."
The Brothers of the Sun Tour begins June 2 in Tampa, Fla., just weeks before the release of Chesney's upcoming studio album, 'Welcome to the Fishbowl,' out June 19. The new project features the 'Feel Like a Rock Star' duet with McGraw, as well as the new single, 'Come Over.' Click here to learn more about the tour and upcoming album.


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58 's
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Primary Material: Clay
Color: White
Fab items thank you so much! i will be back! :D x
Thanks Lisa! I looooove what I got, I think the little witches have to be my most fave though! xo Bella
If there is a fave item you don't see or have a custom request, please let me know!
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K&N Custom Racing Assembly DDO 9'' x 5 1/2'', 3 1/4'' Height
- Provides Maximum Performance for Carburetors
- Provides Critical Filtration
- Durable Filter Material
- Washable and Reuseable
K&N Custom Air Filters for Single or Two Barrel Carburetors.
K&N Custom Air Filter kits are designed to allow the maximum performance from your carburetors, yet keep the dirt on the outside where it belongs. These assemblies come with custom chrome top and base plates and the famous K&N High-Flow Washable Air Filter.
Application List
Height: 3.5 in (89 mm)
Replacement Filter: E-3461
Finish: Chrome
Length: 8.875 in (225 mm)
Width: 5.25 in (133 mm)
- 56-1255
- 56-1255
- New
Shipping Information
- Item Requires Shipping
- 2.0 lbs.
- W10.4000" x H7.8000" x L10.4000"
Customer Reviews
Total Reviews (0)
Write the First Review!
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- Shock Rebuild Get a Quote to Rebuild your Shocks!
- Fast Shipping Fast same day shipping if your order is placed before 12pm PST * Click for Details
- Careers Now Hiring , Apply Now
- No Hassle Returns If you are not satisfied we make it easy for you to return your item.


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4079000500 Saf Truck Brake Disc - Chinaprice: contact company for price
Fitting Position: Front Axle
Ø: 430 mm
Height: 130 mm
Brake Disc Type: Internally Vented
Br. Disc Thickness: 45 mm
Min. thickness: 37 mm
Num. of holes: 12
Pitch Circle Ø: 168 mm
Material requirements:
1. Must meet Grade GG20 for gray iron castings
2. Chemical Composition ( Percent)
* Total Carbon: 3.0 - 3.50%
* Silicon: 1.90 - 2.30%
* Manganese: 0.60 - 0.90%
* Phosphorus: 0.12% Max.
* Sulfur: 0.10% Max.
3. Microstructure:
Graphite Structure: Predominantly type A, size 3- 5.
Matrix: Pearlistic with max. 15 ferrite. Free from chill
4. Physical Properties
Tensile Strength: Min. 200 N/ mm
Brinell Hardness: 190 ~ 230
Company Contact:
- Posted By: Shanghai Winsun Automotive Co.,Ltd
- Phone: 862158309961
- Address: UNIT 802,NO.1476,PUDONG AVENUE,SHANGHAI,P.R.C, Shanghai, China
- Email:
- Website: http://www.wsautomotives.com
Published date: July 7, 2014 -
- Business Description: Winsun Automotives (Shanghai) Co.,Ltd. is a spirited company that has
advanced market idea and various spare parts international trade
experiences. Our company provides one stop solution service for
various auto spare parts of commercial vehicle such as the
truck(Mercedes Benz, Man, Volvo, Daf, Scania, Iveco And
Renault.)ã€trailer(BPW, Fuwa, Fruehauf, York, Saf etc.),and engineering
truck etc , These parts are made to exact specifications and under go
the same rigorous quality assurance tests as any other truck parts, the
only difference being that we can offer them to you at a much lower
price. we quickly react and keep improving, from inquiry, order,
delivery and after sale service, customer is our most concern. We supply
spare part products with high Quality to Europe, America, South America,
Middle East as well as Africa, gaining increasing international
regulation from our regular and new customers abroad.
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Wabash College Passes All-Time Record for Applicationsby Howard W. Hewitt • February 23, 2007 Share:
Wabash College has received 1,400 applications for the class of 2011, not just an all-time high but nearly twice as many as a decade ago.
Admissions received its 1,400th application Friday morning. As a matter of fact, applications have come in at a record pace all year. Admissions passed the 1,000 mark just before Christmas, the earliest ever. In 2000, the admissions department passed 1,000 applications for the first time.
"That was seen as a significant breakthrough as the College leadership at the time thought that was the pool we needed to recruit a strong class at a sustainable level of financial aid," Dean of Admissions Steve Klein said.
In the 1990s the College often averaged about 800 applications. In 1997, applications totaled 735. Three years ago applications reached 1392, with last year's total at 1361.
The admissions staff spends much of its time reviewing applicants they believe would make a good Wabash man. The class of 2011 won't be much different in size than in recent years with about 250 freshmen.
Klein noted there have been major and minor changes in the recruitment effort.
"We've implemented an aggressive and comprehensive summer recruiting program to contact rising seniors before their school year starts," he said. "This includes mail, phone contact, and visits."
He also noted the strength of the alumni volunteer program and friends of the College aiding recruitment. Klein said the department has worked to enhance relationships with the athletic department to support collaboration in prospect management.


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Opening This Weekend: September 21, 2012 [VIDEO]
Looking to see a movie this weekend? Before you head out, check out the trailers for movies opening this weekend.
In a violent, futuristic city where the police have the authority to act as judge, jury and executioner, a cop teams with a trainee to take down a gang that deals the reality-altering drug, SLO-MO. - IMDB
End of Watch
Two young officers are marked for death after confiscating a small cache of money and firearms from the members of a notorious cartel, during a routine traffic stop. - IMDB
House at the End of the Street
A mother and daughter move to a new town and find themselves living next door to a house where a young girl murdered her parents. When the daughter befriends the surviving son, she learns the story is far from over. - IMDB
Trouble with the Curve
An ailing baseball scout in his twilight years takes his daughter along for one last recruiting trip. - IMDB
17 Girls
When Camille accidentally becomes pregnant, 16 of her friends and classmates decide to follow suit, throwing their town and school into chaos. - IMDB
About Cherry
A drama centered on a troubled young woman who moves to San Francisco, where she gets involved in pornography and aligns herself with a cocaine-addicted lawyer. - IMDB
The Perks of Being a Wallflower
An introvert freshman is taken under the wings of two seniors who welcome him to the real world. - IMDB


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By completing your order, you understand that the products(s) you are purchasing are U.S. models and may have power / voltage requirements different from that of your country.
Prices shown in currencies other than US Dollars are estimates based on current exchange rates. We will charge your credit card in US Dollars on the day your order is shipped, and the conversion to your local currency will be done at the prevailing rate by your credit card issuer.
ProSound and Stage Lighting will not mark your parcel as a "gift", declare a value lower than the actual price paid, or otherwise prepare false customs information.
The new colour chorus series is available in 1, 2, 4, and 6 foot fixture lengths, featuring 192 x 3W RGBA LEDs, 100,000 hour average LED life, individual hue, saturation, and intensity control, LED group control, variable dimming curve modes, strobe and chase effects, ArtNet, KlingNet and Remote Device Management, protocol support, 3 and 5-pin DMX, powerCon, and RJ45 in/out connections, LCD menu display with 4 button control panel, integrated rigging brackets, multiple unit power linking, rugged die-cast aluminum exterior, flicker free operation for TV and film, and a multi-voltage universal auto switching power supply (110-240v).Features:


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Layouts and Views
- 1 My Theme -> Layouts and Views
- 1.1 Layout Manager
- 1.1.1 Videos
- 1.1.2 Introduction
- 1.1.3 Header Module
- 1.1.4 Navigation Module
- 1.1.5 Image Module
- 1.1.6 Widget Bar Module
- 1.1.7 HTML Module
- 1.1.8 Content Module
- 1.1.9 Footer Module
- 1.1.10 Applying Layouts to Specific posts/Pages
- 1.2 Views
- 1.1 Layout Manager
My Theme -> Layouts and Views
Layout Manager
Go to My Theme -> Layouts and Views to access the Layout Manager.
Screenshot of default layouts in Builder:
A layout is an arrangement of modules. Think of modules as building blocks for the layout. Builder comes with 9 layouts by default. You can create any number of layouts from scratch or duplicate existing ones and apply layouts to individual pages, individual posts, front page, blog page, archives view, tag view etc.
You may want to follow these steps:
- Pick a layout that's closest to how you want your site to be and create its duplicate.
- Right Sidebar is typically what you would want to start off with. Place the mouse cursor on Right Sidebar and the link to Duplicate it will be visible. Click on it, provide a new name (say, Main) and click Create Layout.
- Set your new layout as the default. Place the mouse cursor next to the new layout you just created under the Default Layout column and Set as default link will appear. Click on it.
Now your 'Main' layout is ready to be customized. Click on its name to edit the modules that make up this layout.
Do not forget to save the layout when you are done editing it.
These are the different types of modules:
- Content Module
- Footer Module
- Header Module
- HTML Module
- Image Module
- Navigation Module
- Widget Bar Module
Header Module
To be added
A Navigation bar module can be one of these four types:
- Builder Settings Pages
- Builder Settings Categories
- WordPress Pages
- Custom Menu
Builder Settings Pages
This module shows the page titles as menu items. Only those page titles will be shown in the navigation bar that have been ticked in the Menu Builder section at My Theme -> Settings. Child pages are displayed as sub menus. The default menu item in this type of navigation module is Home that links to your site's front page.
The order of pages in the menu can be changed by setting page Order for the pages (either in the page editor screen or at Pages -> Edit -> Quick Edit). A page with lower order number will be shown first (left) compared to a page with higher order.
Builder Settings Categories
This module shows the category titles as menu items. Only those category titles will be shown in the navigation bar that have been ticked in the Menu Builder section at My Theme -> Settings. Child categories are displayed as sub menus.
The order of categories in the menu can be changed by using Category Order plugin.
WordPress Pages
This module uses the output of wp_list_pages function. Child pages are displayed as sub menus.
The order of pages in the menu can be changed by setting page Order for the pages (either in the page editor screen or at Pages -> Edit -> Quick Edit). A page with lower order number will be shown first (left) compared to a page with higher order.
Custom Menu
This module uses custom menu that is created at Appearance -> Menus.
Image Module
Image module is typically used to display header images.
In the module's settings, we can upload an image, let the height be automatic or set its height manually, specify Link URL and whether or not the linked URL should open in a new window (default is to open in the same window). We can also specify any of these for sidebars:
- No Sidebars (default)
- 1 Left
- 2 Left
- 1 Right
- 2 Right
- Split (1 Left & 1 Right)
- To avoid resizing of the image after upload, ensure that width of image is exactly equal to Layout width minus the total width of sidebar(s) (if any). Also ensure that the height of the image is the same as the height value specified in the module's setting.
- If the uploaded image is not appearing on the site, make sure that uploads folder is set to wp-content/uploads at Settings -> Miscellaneous. If the issue continues, ensure that GD image library is present in your hosting environment.
Tip: A HTML module or widget bar module will give you better control if you want to use a sidebar.
Widget Bar Module
HTML Module
Content Module
The actual Page/Post etc. content will be shown inside the content module. Therefore, ensure that default layout in your site has the content module. A layout can and will have only 1 content module.
Content module can have
- No Sidebars
- 1 Left
- 2 Left
- 1 Right
- 2 Right
- Split (1 Left & 1 Right)
When entering custom width(s) for the sidebar(s) ensure that "px" is not present next to the value.
A layout can and will only have 1 footer module.
Like other modules, footer module can have
- No Sidebars (default)
- 1 Left
- 2 Left
- 1 Right
- 2 Right
- Split (1 Left & 1 Right)
To learn how to edit the content of footer, follow this.
Applying Layouts to Specific posts/Pages
A layout can be applied to any post or Page while that post or Page is being added/edited.
Note: When Front page is set to display a static Page at Settings -> Reading, a layout applied to Home will not get applied. Same is the case with Posts page. In this case, views must be used.
The power of Builder (layouts) can selectively be applied to specific sections of your WordPress site called Views.
Apply Layouts to Specific Views
To apply layouts to specific views, go to Layout Editor (My Theme -> Layouts & Views) and click on Views tab. Then click Add View button.
These are the available views:
- 404: This view represents (web)pages (controlled by 404.php) that come up when a non-existent (in your site) URL is accessed.
- Archives: This view represents pages (controlled by archive.php) that come up when a archive link is clicked. Examples of archive pages (these are listing pages, i.e., having multiple posts rather than a single entry) are: Category pages, Author pages, Tag pages, Date archive pages.
- Attachment: This view represents pages (controlled by attachment.php) that come up when any attachment (files like images that can be seen in WordPress Media Library ) is viewed.
- Author: This view represents pages that come up when link to a author is clicked.
- Blog: This option appears only when a Page has been set as Posts page at Settings -> Reading i.e., when a static page is set to appear on Front page. This view represents the Posts page (Example: /blog or /news) which uses index.php (unless an extension is used in which case, extension's functions.php will be used)
- Category: When this view is selected, another dropdown named "Category" appears from which a category can be selected to which the layout should be applied. This view represents any page that lists posts belonging to a particular category.
- Date Archive: This view represents the date-based archives list pages (controlled by date.php).
- Home: This view represents the front page.
- Page: This view represents a Page.
- Post: This view represents a Post.
- Post Type - Widget Content: This view represents a single entry of "Widget Content" custom post type. Widget Content comes by default in Builder. Each custom post type (Ex.: Projects in Covell child theme) will automatically appear in the View selection dropdown.
- Search: This view represents the search results page (controlled by search.php)
- Singular: This view represents Any post, page, or attachment. Post, Page, Attachment views if present will take precedence over this.
- Tag: This view represents that page that comes up when a tag is clicked.