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The last major casting piece for the "The Longest Ride" has fallen into place, and he has quite the familiar face.
Alan Alda, who has appeared in everything from his Emmy-winning turn on "M*A*S*H" to "The West Wing" to his latest stint on NBC's "The Blacklist," has joined the cast of the Nicholas Sparks adaptation, set to begin filming in Wilmington June 16.
Alda will play Ira, a 90-year-old man trapped in his car after an accident on a snowy, isolated road. Fading in and out of consciousness, Ira begins reminisce about his life with his late wife in the years following World War II, when he struggled to return to normalcy and they became art collectors.
Previously, Alda traveled to the region to shoot the film, "Betsy's Wedding" in the fall of 1989 and spring of 1990.
Last week, it was announced that "Boardwalk Empire's" Jack Huston would play a younger Ira in flashbacks, alongside "Game of Thrones'" Oona Chaplin as his wife, Ruth.
The dual-romance film will also feature another love story unfolding just a short distance from Ira's car accident, which finds a young college student ("Under the Dome's" Britt Robertson) falling for a handsome bullrider (Scott Eastwood).
George Tillman, Jr. will direct as screenplay by Craig Bolotin, Brad Desch, Scott Neustadter and Michael Weber.
In addition to its local filming, "The Longest Ride" is also expected to shoot scenes in Winston-Salem.
The film will be release April 3, 2015.


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Former "Knots Landing" star Joan Van Ark is living proof that you should never schedule a chemical peel moments before a red carpet event!
The 64-year-old, with tattoo-ish Liza brows and Sharpie eyeliner, was out at a theater event in L.A. on Saturday.
Her new look is in stark contrast to her CBS publicity photo (inset) from a few years ago. Damn!
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I was reluctant to share this story, because it feels self-indulgent, somehow (unlike, say, the rest of this blog? This blog that is all about me?) but then I read this and thought, hell, that's good reading!
So here's mine. This is not for the squeamish; there are bodily fluids and shrieking and Dan Rather sightings.
It was fourteen days exactly before the baby was due. I was at my weekly midwife appointment, and I was leaking. "I think," I told the midwife, "that my water broke. Or, you know, is breaking."
My husband was there. Because I was huge and cranky and exhausted, he had offered to come with me. I wouldn't miss an opportunity to make him go to one of the endless number of appointments I had endured, so I said yes.
The midwife took a sample of the fluid, did whatever the hell they do with these things, and said, "That's amniotic fluid, all right. How long have you been leaking?"
"A week," I said, "About. I think." (At my appointment the week before, I had mentioned the leakiness and the other midwife pooh-poohed my concerns. "That's not amniotic fluid," she had said, then added something like, "It's another in a variety of disgusting fluids that spill from a woman as her body prepares itself for childbirth.")
"Huh," said the midwife. We were both being decidedly blasé about this, as if the kid inside me could hear and we didn't want to panic him. "That's quite a while! So we're going to have to get you into labor today, then." She wrote a note down on my chart. My heart began to flap around my chest and my husband was squeezing my arm in a way that made me want to kill him. "We're going to have a baby today, hon! We're going to have a baby today!"
The midwife instructed me to scooch down and she poked around in my innards. This was most unpleasant, and did not even approach the unpleasantness that labor would probably be. My heart tried to exit my chest. "Well!" said the midwife. "You're not dilated in the least. You have a long way to go. So I want you to go home, relax, and take some castor oil."
In case you don't know, castor oil is the midwife's favorite method of getting labor to start. I think, basically, it irritates your digestive system until fluids spew from every orifice, and then your body decides, while it's cleaning house, to toss the baby out, too. At least this is my primitive understanding of the castor-oil magic. It is natural, which means that it is disgusting. Why did I ever go the midwife route?, I wondered. At that moment it seemed preferable to simply be punched in the head until unconscious, the child removed from me with forceps and a buzz saw.
I staggered out to the reception area, where Scott was announcing to anyone who would listen that we were going to have a baby that day. My head was swimming. Everyone was staring at me like I could blow at any moment. We went outside. A small black poodle on a leash almost tripped me, and I thought, that's the last dog I'll see before I become a mother. Then I saw a Jack Russell, and I realized what a stupid game this was to play, especially on the Upper West Side and everyone with their damn dogs.
Waiting for the subway to take us home, Scott kept examining my face and asking me if I was all right, if I was nervous or excited or what. My face was slack with fear and I couldn't move my lips. The train arrived. We sat down on the 2 train going express to Brooklyn. Castor oil, I thought, And my body said, oh no you don't, and promptly went into labor.
There was no mistaking it. I could hear Scott asking me if I was okay, and I kept waiting for the contraction to go away so that I could tell him—hey, guess what I just had!—but it never did. As soon as one contraction faded, whoopsie daisy, there'd be the next. Not only was I in labor, but my body had bypassed the introductory stages and had gone straight to the high-intensity phase.
Eventually Scott managed to decode my hand gestures and figure out what was going on. So did the rest of the car. Two women across from us chortled at me and reminisced about giving birth to their babies. "I wouldn't be in her shoes for a big price," one of them said. "You can tell me," the other said, "because I know. Never again would I do that." I CAN HEAR YOU, I wanted to scream, but unfortunately I couldn't move or speak.
"Shouldn't we get out? Don't we need to get to the hospital?" said Scott. I squeezed his hand harder. No, you idiot. No hospital. Home. Please don't make me go to the hospital. I will divorce you right now if you make me go. I communicated all of this in a series of hand squeezes.
You know this part if you've had a baby already: everything you read, every doctor you speak to, every hospital orientation you attend, every labor preparation course you take, they all tell you the same thing: don't go to the hospital right away. We won't admit you until you're four centimeters dilated! they say. You'll probably panic at those first contractions and think you need to go to the hospital! But you won't! Stay at home and be comfortable and don't bother the hospital until you're absolutely certain! Maybe then you can come. Maybe. But until then we don't want you. So don't go to the hospital! Did you hear us? Were you listening carefully, when we said the part about waiting? Please sign this form that tells us you understood that part, because Jesus we don't want you. Until, you know, such time as you're truly, absolutely ready. But at that point when you think you should come, it will probably be even a few hours later than that. P.S.: Don't come here.
Given that, there was no way, a few minutes after being told I wasn't dilated at all, that I was going to defy the authority of all the people who are supposed to know about these things. Oh, would they be disappointed in me. They would shake their heads and toss us to the street and I'd have to stagger around the Upper West Side for hours, throwing up in garbage cans and sickening pedestrians.
That said, as the stops lurched by, I began to suspect that I had made a poor decision.
When we got to Brooklyn, I found that I could no longer walk. I had to wait for the few seconds that the contractions would die down to a manageable level to scuttle, crab-like, on all fours until another contraction came, at which point I'd lie down on the cool pavement and wish for death.
Finally we got home, but the easing up of the contractions was not happening as I had planned. I was not even a bit more comfortable. More fluids were seeping down my thighs and pooling in my shoes. I was sticky and hot and in pain and I smelled. I had hoped to change my clothes, but there was no hope of that now. It was all I could do to shoo away our dog Charlie, who was digging his snout into my damp overalls like I had hidden snacks somewhere in there. Apparently I smelled like a giant Snausage. Scott called the midwife, who told us to head straight for the hospital. What had we been thinking, she asked, going all the way home?
Somehow, someway, we had to make it back uptown from Brooklyn. And by now it was rush hour. Scott called a car service, informing them that they were transporting a woman in labor and they had better give us the very best car, not one of those ones with the cloying air freshener thinly masking the cigar stink or with the driver eating a gyro. A few minutes later, a spanking clean car arrived, the driver avoiding eye contact with me as he placed my suitcase carefully into the trunk. We made it across the bridge and saw the cars at a dead stop, snaking all the way across Canal Street.
That's okay, I thought, I'll just give birth in the car, and what a story we'll have! Maybe we'll be on the news! I underestimated, however, the skills of our driver, who made a few hairpin turns and twists and navigated us onto less clogged streets as we hurtled toward the West Side Highway. His decisive driving skills with his enthusiastic use of the brake and gas pedals caused a curious shrieking sound to emanate forth from behind my clenched teeth. Nonetheless I was pleased to see that we were making progress, even as I felt I might puke upon my husband.
As we made our way uptown I attempted to breathe deeply and remain calm. I assessed the back of the driver's head and wondered, in case we hit more traffic, how good he'd be at delivering a baby. He was a clean-cut young man. Every one of his well-groomed hairs positively trembled with anxiety. He was trying so hard to not to look behind him and see if I had befouled his tawny leather seats with any baby-related messes. He was a good boy and deserved better than this. Between contractions, I gazed tenderly at his neck.
As we exited the West Side Highway, my husband whispered the words every woman hopes to hear during labor: "Look, honey, there's Dan Rather." I managed to look up and there, indeed, was Dan Rather. Not holding up a placard that read "Go, Alice! Go!" but instead standing on the corner waiting for the light to change. That's the last celebrity I'll see before I become a mother, I thought. Then I thought, wouldn't it be funny if Jerry Orbach were standing on the next corner! Then I returned to my suffering.
When we got to the hospital I assumed that nurses would come running to my aid, whisking me up to L& D where they would divest me of my clothes and place me gently upon the delivery table and then hand me my baby. But when we got there, no one seemed to be ready for us or even particularly concerned that we were there at all. I sat in the car and panted, the driver in front of me still staring straight ahead and gripping the steering wheel, while Scott went to get the army of helpers. Finally he came pushing a Victorian-era wheelchair and tried to convince me to get in. All at once my discomfort was impossible to bear. I had been fairly quiet before this, but as he wheeled me into the hospital, I began to scream. I figured I deserved at least this much.
We arrived at a room that was the wrong kind of room. "Why aren't we in Labor and Delivery?" I asked Scott, who was talking to the triage nurse. Triage! I was not to be triaged! Didn't these people understand that I was about to have a baby? But there I was, being wheeled into triage with all kinds of other women who were clearly not as uncomfortable as I. They were quiet and still. Some of them were sleeping. Sleeping! We got to an empty bed and the nurse instructed me to take off my clothes and put on a gown. It seemed like an impossible, cruel thing to ask, but somehow, together, Scott and I complied. The nurse hooked me up to the monitor, and then she gaped at the high peaks and the dizzying numbers and said, "Whoa! You sure are in labor!" and I said "NOW DO YOU SEE."
Minutes later I was sitting on the bed in a delivery room, thrashing about on a tangle of soaked and bloody sheets, pleading with the nurse to get me something for the pain. The contractions had been completely overshadowed by blinding, searing pain shooting down my left leg. It seemed that the baby, who did not quite get that he already had my attention, was resting on the sciatic nerve and with every contraction decided to press on it with all his might. At any moment my leg would pop off and land somewhere across the room.
I was panting "My leg my leg my leg" but all I could manage was "ma-LEH, ma-LEH," and the nurse was on the other side of the room, doodling on some paperwork and absentmindedly murmuring, "Who's Molly, sweetheart?" She turned and saw me sitting up and suggested that I lie down, but that seemed like the Worst Idea Ever, and so I ignored her. Then the midwife came in and said, "Wow, look at that bloody show," and I thought, on with the bloody show, but couldn't share my funny line because my leg was being sawed off by a thousand tiny and invisible gnomes. I mouthed "epidural," and the midwife saw the gleam in my eyes and she nodded.
At that point Scott, who had been out of the room doing god knows what—probably kissing some hot nurses who weren't soaked in meaty sauces—came back to me, and I began to relax a little. And the anesthesiologist came in and delivered the epidural, which immediately numbed my left leg but didn't change the contractions a bit. He explained that it might take a few minutes and for me to relax. I was jubilant that the sciatic pain had disappeared, that I was going to keep both legs after all. I was trying to explain to Scott how it was interesting that, between contractions, there's no pain at all, and you feel like this is all quite manageable, until your insides begin contracting again—only I couldn't get enough of it out before another contraction began. And by then, curiously, I had begun to moo with each contraction. So I sounded like this. "Actually this isn't so bad—MOOOOOOOOooooo—because between the contractions the pain just—uuummmmmmmmoOOOOOOO—sort of goes away and then you—MUUUUUUUUUMMMMMUUUHHHHHHH. You know?" Scott tried not to laugh.
I couldn't help but notice that the contractions weren't decreasing in intensity in the slightest, and I asked the anesthesiologist what was up with that. In response, he backed away and ran for the door. All I could hear were his footsteps retreating rapidly down the hall. Then the midwife checked me and said, "Well, here's why it didn't work. I can feel the baby's head."
Now I was called upon to push. Only, because of the epidural that had not accomplished shit for the contractions, I was completely numb around the area toward which I was supposed to push. I had no idea what I was doing. Everyone would ask me if I wanted to push, and I would say, "Sure, I guess," and I would attempt something like pushing, and the midwife, who had a thrillingly low voice with a sexy Slavic accent, would purr, "You are not pooshing, you are making a poooshing face," and she would be right. Then she claimed to be pressing on my delicate feminine parts and she would say, "Poosh right there, where I'm pressing," only I couldn't feel a thing. So I would pretend to push some more, and then everyone would cheer, and I would guess that time I was actually pooshing and not merely making the pooshing face.
The mood in the room became strangely casual. I was sucking on oxygen because the baby's heartrate had dipped slightly and my head was spinning. I said to Scott, "I love the music they're playing in here. That's so nice, that they pipe in classical music for you." And he said, "Honey? That's your CD. The one you burned a few days ago." The nurse and midwife would drift away between pushes, gathering in the corner to do something I couldn't see (smoke? Eat fistfuls of Cracker Jack?) until I called out, "Hello? I, uh, think I could push now," and then they would return and I would do my best imitation of a woman pooshing and not just, etc.
After what felt like hours of this, but was in fact only fifteen minutes, the nurse and midwife began to exclaim over something—something coming out of my vagina! "What is it?" I asked, and they said, "It's a baby!"
Because of the epidural that had robbed me of all ability to feel what was happening to my poor vagina, I was spared the so-called Ring of Fire sensation, in which the baby's head stretching everything to its outermost limits and beyond, causing you to believe your vestibule may in fact be aflame. Nonetheless I still had Johnny Cash in my head as I pooshed. And pooshed. Love is a burnin' thing. Doo doo-doo doo-doo doo doo doooo. And it makes a fiery ring. "Look at his eyelashes!" the nurse exclaimed, and my husband looked down and said, "Oh my god," and I said, "Are they longer than his head? Is he some kind of fringed freak? Will he make us some circus money?" Only I didn't say any of these things because I was mooing.
I pushed a little more, and all at once the baby flopped right out of me and was placed on my stomach. It was an indescribable pairing of events—there was a tumbling sensation, a slipping away, and HOLY SHIT IT'S A BABY AND IT'S RIGHT THERE ON ME. Our hot and gooey baby was wailing and he was more beautiful than I had dreamed and he was ours. All we could say was, "Hello! Hi! Hi, Henry! Hello there!" We waited a year and then he finally said hello back.


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Bucs fire head coach Schiano after two seasons, let go of GM Dominik
The Tampa Bay Buccaneers are changing directions on their rebuilding project – again.
Coach Greg Schiano was fired Monday after two losing years extended the franchise's playoff drought to six seasons. General manager Mark Dominik was also ousted, ending an unsuccessful five-year stint that produced flashes of hope but far more disappointment than ownership felt was acceptable.
"The results over the past two years have not lived up to our standards and we believe the time has come to find a new direction," Bucs co-chairman Bryan Glazer said in a brief statement released a day after a season-ending 42-17 loss to the New Orleans dropped Schiano's record to 11-21.
"Mark has been a valued member of our organization for two decades and we respect the passion he showed for the Buccaneers during his time here," Glazer added. "We thank Greg for his hard work and effort the past two seasons, but we feel these moves are necessary in order to achieve our goals."
In typical Bucs fashion, the reclusive owners of the team announced the third coaching change in five years with a one paragraph statement and did not schedule a news conference to discuss the situation. Schiano had three years and $9 million remaining on his contract.
Word broke less than 30 minutes after the team closed the locker room, where players were sorting through equipment and belongings before scattering for the offseason. They met with the coaching and medical staff for exit interviews and physicals and had not been informed of the dismissals before media was allowed into the room.
Many, including Pro Bowl defensive tackle Gerald McCoy, had hoped Schiano would keep his job.
"It's tough for the players to see your coaches go. You never want to see anybody get fired," McCoy said after the announcement.
"Me personally, I haven't had any consistency in my career. Third head coach, going on my fifth year and three head coaches. Add up everybody, it'll be six d-line coaches."
The Bucs went 7-9 in their first season under Schiano, collapsing after a 6-4 start that had the team in playoff contention.
After trading for three-time All-Pro cornerback Darrelle Revis and signing safety Dashon Goldson in free agency to bolster a porous defense, the team entered training camp this season with heightened expectations.
But a messy split with former quarterback Josh Freeman, an outbreak of MRSA infections in the locker room and reports that Schiano was losing the support of players tiring of his rules and coaching style dogged the team during an 0-8 start that put the coach's job in jeopardy.
Despite having a rookie quarterback and finishing with 16 players on injured reserve, including running back Doug Martin and receiver Mike Williams, the Bucs went 4-4 over the second half of the season. That hardly seemed like progress, though, because the offense got progressively worse and finished last in the NFL in passing and total yardage.
Still, players seemed impressed with the way Schiano held the team together, insisting right up until the end that the coach never lost the locker room.
"In times like that you see a lot of guys crumble, a lot of guys break. You never saw a different attitude with him," McCoy said.
"You could never see if the media was getting to him or see if anything we were doing was getting to him. He came in every day and was the same person, regardless," McCoy added. "… He's the most consistent thing in the building, I will give him that."
Schiano was hired in January 2012, leaving Rutgers to take over a team that ended its final 10 games under Raheem Morris on a 10-game losing streak. He inherited one the NFL's worst defenses, but also a young quarterback in Freeman, who won 10 games in his first full season as a starter and became the franchise's first 4,000-yard passer in Schiano's first year in Tampa Bay.
But Freeman's relationship with Schiano soured when the Bucs dropped five of the final six games of 2012, with Freeman's inconsistency contributing to the slide. The fifth-year quarterback was benched and subsequently released after an 0-3 start this season, replaced by rookie Mike Glennon, a third-round draft pick who went 4-9 in 13 starts.
The Bucs have not made the playoffs since 2007. They haven't won a postseason game since their 2002 run that produced the franchise's only Super Bowl title.
Part of the blame for the poor performance rests with Dominik, who was named general manager in 2009 – the year Morris was promoted from defensive coordinator to replace former coach Jon Gruden.
Dominik survived Morris' firing after a 4-12 finish two years ago. But in the end, a spotty draft record, the mishandling of Freeman's situation, and the team's 28-52 mark during a five-season tenure as GM became impossible to overlook.


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In 1978 he originated Exceptional Cancer Patients, a specific form of individual and group therapy utilizing patients' drawings, dreams, images and feelings. ECaP is based on "carefrontation," a safe, loving therapeutic confrontation, which facilitates personal lifestyle changes, personal empowerment and healing of the individual's life. The physical, spiritual and psychological benefits which followed led to his desire to make everyone aware of his or her healing potential. He realized exceptional behavior is what we are all capable of.
Bernie, and his wife and coworker Bobbie, live in a suburb of New Haven, Connecticut. They have five children and eight grandchildren. Bernie and Bobbie have co-authored their children, books and articles. Their home with its many children, pets and interests resembled a cross between a family art gallery, museum, zoo and automobile repair shop. It still resembles these things, although the children are trying to improve its appearance in order to avoid embarrassment.
In 1986 his first book, Love. Medicine & Miracles was published. This event redirected his life. In 1989 Peace, Love & Healing and in 1993 How To Live Between Office Visits followed. He is currently working on other books with the goal of humanizing medical education and medical care, as well as, empowering patients and teaching survival behavior to enhance immune system competency. Bernie's realization that we all need help dealing with the difficulties of life, not just the physical ones, led to Bernie writing his fourth book in 1998 Prescriptions for Living. It helps people to become aware of the eternal truths and wisdom of the sages through Bernie's stories and insights rather than wait a personal disaster. He wants to help people fix their lives before they are broken, and thus not have to become strong at the broken places. Published in 2003 are Help Me To Heal to empower patients and their caregivers and 365 Prescriptions For The Soul, in 2004 a children's book about how difficulties can become blessings, Smudge Bunny, in 2005 101 Exercises For The Soul and out in the Fall of 2006 a prescriptions for parenting book Love, Magic & Mud Pies.
Woody Allen once said, "If I had one wish it would be to be somebody else." Bernie's wish was to be a few inches taller. His work has been such a growth experience that he is now a few inches taller. His prediction is that in the next decade the role of consciousness, spirituality, non-local healing, body memory and heart energy will all be explored as scientific subjects.
For many, Bernie needs no introduction. He has touched many lives all over our planet. In 1978 he began talking about patient empowerment and the choice to live fully and die in peace. As a physician, who has cared for and counseled innumerable people who's mortality has been threatened by an illness, Bernie embraces a philosophy of living and dying that stands at the forefront of the medical ethics and spiritual issues our society grapples with today. He continues to assist in the breaking of new ground in the field of healing and personally struggling to live the message of kindness and love. Bernie and Bobbie travel extensively to share his experience and techniques. His web site is www.BernieSiegelMD.com.


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You will find agricultural and animals expert witnesses by clicking on the one of the following categories. The experts found here may consult regarding agronomy, farm management, and groundwater contamination. These consultants can provide reports on fish, dogs, and horses. They may also testify regarding soil, livestock, and equine insurance, as well as related topics.
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One of the lingering questions surrounding iPhone 4 and the whole "antennagate" saga is just how much, if any, of the problem could be blamed on the traditional network whipping boy, AT&T. Sure, you could reduce or kill iPhone 4 data and voice reception by gripping it firmly around the base to attenuate the signal or touching it at the bottom left corner to de-tune the antenna, but would that be a problem on carriers with stronger networks?
So, the moment I got my iPhone 4 up and running on Rogers Canada yesterday, I aimed to find out and the answer -- is as complicated and confusing as always.
First test was right outside the Apple Store, inside the mall. I had 4 bars on both iPhone 4 and iPhone 3GS running iOS 4.0.1. Holding either one in a death-grip, even lightly, dropped them a bar. Covering the lower-left spot of iPhone 4 also dropped it a bar. Neither had any real-world problems. 3 bars is fine.
Next test was to go out and find low signal areas. Interestingly, driving through areas where iPhone 3GS briefly drops to EDGE, iPhone 4 stayed on 3G longer and came back to it faster. When I stopped and stayed in an area with 1 to 2 bars of 3G signal, that's where the fun began. And by fun I mean crazy.
My results, on both iPhone 4 and iPhone 3GS were all over the place. Again, I could drop a bar, sometimes both bars, by death-gripping either phone or death-touching iPhone 4. Every so often, however, death-touching iPhone 4 got it to jump up to 3 bars. It happened enough that it wasn't a fluke, but I couldn't do it every time. Once I managed to cover enough antenna to get iPhone 4 to search for the network. I couldn't get iPhone 3GS to do that -- it stayed on 0 bars but on network -- but unless I was trying to crush the phone with both hands I'd never hold it that way in real life.
In terms of data speeds, again the results were crazy. I could drop speeds by half with death-grip on both iPhone 3GS and iPhone 4, and death-touch on iPhone 4. Starting from 1 or 2 bars, I could even stop network connectivity completely, again with death-grip on both or death-touch on iPhone 4.
But sometimes only HSDPA (download) would drop while HSUPA (upload) would go up or stay steady. Sometimes the opposite. The results were so crazy, so varied, I'm considering calling the whole thing black magic and just forgetting about it.
So, on Rogers in Canada, death-grip is real but certainly not limited to iPhone 4, while death-touch is also real and limited to iPhone 4 but presents much the same way. Areas of poor signal can be problematic in theory but in a way that's utterly impossible to predict. In practice, dropping calls didn't happen, dropping data was easy to work around, and dropping network had to be forced.
UPDATE: I just ran similar tests on the Nexus One in the same area of poor Rogers reception. Death-touch has no effect, one finger held along the left side drops it a bar and reduces data roughly 25%, death-grip drops 2 bars and reduces data 75%. Death-grip and putting my other hand behind the phone as well killed data but didn't drop any additional bars.
If you've done similar tests, or have similar real-world experience to share on other networks, let us know in comments below!


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Contributions to the Good Samaritan Program make it possible for residents to continue to live at their PMMA community, regardless of their ability to pay. In 2016, more than 330 residents living in Presbyterian Manors of Mid-America's assisted living and health care neighborhoods are supported in some way through the Good Samaritan Benevolent Care Program. This equates to more than $6.8 million a year in unreimbursed care and services.
PMMA conducts two special appeals annually to support this program. The Mother's Day Tribute is conducted in April and May. The Angel Appeal is done in mid-November through the holidays.
You can support the Good Samaritan Program directly by giving online or participating in one of the many Good Samaritan Program fundraisers at your local PMMA community. Through our online giving, you can designate your gift for the benefit of a particular PMMA community.
For more information, contact the PMMA Development office at firstname.lastname@example.com or call 800-336-8511.


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2014-01-17 / Business
Think you need a hearing
If you need or think you might need a hearing aid, you should call Mark Vail today — he'll test and evaluate you for the hearing aid you need in the comfort of your home and you'll be happy with it.
By visiting people in their homes, Mark can make the best assessment of what the person's needs are. Sometimes, he visits people at their places of work because of concerns there. This attention to detail shows up in the low return rate he has.
You can reach Mark Vail at 284-9600 or toll free at 877-284-3400. Call today and you'll be hearing better soon.


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Drivers License
International students may obtain a Texas Drivers License while studying at TWU
Driver's License Information Location (Texas Department of Public Safety)
820 North Loop 288, Denton, Texas (near University Drive/Highway 380 and Loop 288)
Phone: 940-484-6666
Hours: 8:00am-5:00pm, Monday through Friday; closed holidays
Take: Take your VISA, Passport, Social Security Card, Current I-20, TWU Photo ID and Letter Request Form letter.
If you have never had a driver's license before in your own country or in the United States:
You must get a Driver's License Permit (good for one year) by first taking the written test (no appointment is necessary), which is available in English and Spanish.
- After passing the written test, and after practicing your driving with a licensed driver, you can make appointment for the driving test.
- To take the driving test, you must make an appointment the morning of the same day you want to take the driving test. Call 940-484-666 between 8 and 8:15am, or to go to the Driver's License Office and wait in line between 7:45 and 8am.
If you already have an international driver's license, or a driver's license from your own country, it is good for one year after your arrival in the United States; after that time you should:
Take the written test first . . . after passing the written test, then
- Make an appointment and take the driving test
- Take your VISA, Passport, Social Security Card, Current I-20, TWU Photo ID and Letter Request Form letter.
If you already have a driver's license from another state in the United States, it is good for only 30 days in the state of Texas; after that you should go to the Driver's License office and:
You must show that your car's registration has been transferred from the other state to Texas (a Texas registration receipt). You can take care of this at 1505 E. McKinney, Denton, Texas (the Denton County Tax Office). If you are in Houston or Dallas, please ask the Student Life Coordinator or the International Education Office.
- You must show proof of car insurance that meets Texas requirement
- You must surrender (give them) your out of state license
- Take your VISA, Passport, Social Security Card, Current I-20 and Letter Request Form letter
After all the steps are complete, the Driver's License office will issue you a state of Texas driver's license.
For more complete information check out the website of the Driver's License Office.
Page last updated 12:13 PM, March 23, 2017


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17th C
oil on canvas
H 112 x W 140 cm
Accession number
Acquisition method
gift from Thomas Agnew, Esq., 1868
Work type
Salford Museum & Art Gallery
Peel Park, The Crescent, Salford, Greater Manchester M5 4WU EnglandView venue
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Is this scene from an opera by Francesco Furini?
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(c) Pocumtuck Valley Memorial Association, Deerfield MA. All rights reserved.
Contact us for information about using this image.
This memorial commemorates enslaved African Americans of Deerfield, Massachusetts. Designer Shamek Weddle explains:"I was inspired to go beyond regions of ownership and time, a call to and from the past to the future and the present. The 'call' is symbolized in the African drum, communicating to all African Diaspora spiritual presence: past, present and future. My drawing allows Deerfield to join with all other national and international historic sites of the African Diaspora. The cowry shells focuses on African-based religion and values; and how a lot of those beliefs and values have not been completely lost even with such strong culture-killers as the American slavery system--hence the broken chain." The ships that transported Africans across the Atlantic Ocean are represented at the base of the drum.
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See Also...
Pages from Rev. Jonathan Ashley's account book
Bill of sale for slave named Prince
Complaint against slave Caesar for stealing
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i'm a beginner DM trying to get a fantasy game going online.
i need more PCs. want to join? come look at my page!
the setting and adventure types are wide open. i take requests.
the link is in my profile.
hey. i'm in carson, and looking to get a shadowrun group up and going. any interest?


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Celebrating illustration, design, cartoon and comic art of the mid-20th century.
Wednesday, March 31, 2010
The Paperback: Books for "just plain folks"
Henry Pitz writes: [Paperback publishers] have felt the nudge of competition from the books of newer design...
... and they are abandoning the old clichés and experimenting with fresh approaches.
It is only fair to point out that in addition to dozens of mystery and suspense stories,
adventure tales, westerns,
and popular novels which may not be literature but have a legitimate place in our scheme of reading, there are on their lists, in fiction, such names as Dostoevski, Tolstoi, Balzac, Zola, Thomas Wolfe, D.H. Lawrence, and Melville...
... and, among living writers, Rosamond Lehmann, Thornton Wilder, Ernest Hemingway, Aldous Huxley, Robert Penn Warren, Eudora Welty, Robert Graves, John Marquand, and James Michener.
Sol Immerman, vice-president of Pocket Books describes the company's marketing strategy...
"If we constantly realize that the great masses of the American public are, for the most part, just plain folks, we are immediately influenced in our thinking in regards to our approach."
"Each book (by means of its cover) must be its own salesman, advertisement, and direct contact with the buying public. Of course, the basic principles of good selling must govern our thinking. these are : 1. Attract attention; 2. Create interest; 3. Stimulate the desire to purchase."
"Each book is, and must be considered as, a packaging problem of its own. No two books are alike. No set formula can be laid down for all books. What works for one book cannot be expected to work for another."
"Trickiness will not do. It might attract attention, but surely will not fulfill our other two basic requirements.
Busyness - our readers do not have time to study and figure out what we are trying to say. We must reach them quickly, directly, and forcefully. All three sales principles can be lost here."
"Simplicity - if overdone - will not attract attention and so the ability to create interest and stimulate purchases will be lost."
"Bad Taste will offend our consumer. The experience gained in our seventeen years of publishing and selling paperbound books to the great masses of readers throughout the world has given us a fairly accurate picture of our markets, reading habits, tastes, likes and dislikes. This applies not only to what these readers like to look at, but also to the kind of books they like to read."
1. "What is our objective? To sell the most copies of each book we publish. 2. To whom do we wish to sell these books? To the greatest number of people in what we call America's mass market."
This ultimate goal for each book is sought after with the watchwords of the founders of our company - "To reach the greatest number of readers with the best books, for the least money."
* Accompanying this week's excerpts from the American Artist article are a broad sampling of mid-century paperback cover scans generously provided by one of my contacts on Flickr, UK Vintage. Many thanks Uilke!
5 comments:
I have to compliment you leif on the past weeks insight into the paperback market. Your choice of covers and quotes have hit their mark.ReplyDelete
- Anonymous4:28 PM
Hi Leif,ReplyDelete
Thanks for lowering your sights a bit and featuring some of the lurid, lowbrow stuff that characters of my ilk enjoy. You sir, are a Great Canadian!
Happy Easter too, BTW.
It is interesting that these books were for the purpose of rapid mass sales, to be read but were not marketed to be collected and valued as high quality literature. Yet, the cover illustrations are, in many cases, well thought out esthetically, dramatically lit, and skillfully rendered with as much care and talent as a hard bound classic novel in the finest collections. I would venture to say that the quality of the illustration of many, were on the same level as the slick woman's magazine covers and editorial stories of the day. In spite of today's changed market, I can't help but think that human nature still responds to illustrations in advertising, magazines and books, as well as fine art paintings that are traditionally well designed and rendered, just as it always has. Perhaps, the cart is now leading the horse.ReplyDelete
Tom Watson
Thanks guys - your comments made it all worthwhile. Be sure to visit my friend Uilke's (aka UK Vintage) Flickr collection - without his generosity I wouldn't have been able to "illustrate" the text so effectively. Hope everyone has a pleasant Easter weekend! :^)ReplyDelete
- charlie allen8:07 PM
LEIF....Great week, and totally entertaining. Love 'em all....the good, bad, tawdry....whatever. They're, for the most part, well designed, drawn, painted, dramatic, and it was SUCH a market!! Hundreds, probably thousands of books...aimed at the mass market, which today is no doubt into digital everything, TV soaps or junk programing....but hey, it's our entertainment culture. And as said before, a big venue for 'needy' artists, actors, writers and creative folks. Thanks again, cheers, and hopefully a relaxing Easter weekend.ReplyDelete


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Philippine Airlines Selects V2500 Engines for Airbus Aircraft
Paris Air Show (June 18, 2013) – Philippine Airlines (PAL) has selected IAE International Aero Engines AG's V2500 engine to power its order for 34 A321 aircraft.
The V2500 deal includes a V-ServicesSM Fleet Hour Agreement (FHA). Deliveries are scheduled to begin in August 2013 and continue over a four-year period.
"We selected the V2500 engine for its superior fuel burn advantage and world-class reliability," said Ramon S. Ang, president and chief operating officer of Philippine Airlines. "The engines are part of a major fleet modernization program we are undertaking. We look forward to our new relationship with IAE."
"We are excited to have Philippine Airlines, Asia's first commercial airline, as a customer," said IAE President Jon Beatty. "The pairing of the V2500, a proven and dependable engine, and PAL, a well-respected operator, makes a great combination."
The V2500 remains the most preferred engine for the A321 aircraft, powering over 60 percent of the aircraft in service – and has also been selected to power over 70 percent of the aircraft in firm backlog. A321 aircraft powered by V2500 engines offer customers a significant improvement in operating cost due to the superior fuel efficiency and improved time on-wing.
About PAL: As the first airline in Asia, Philippine Airlines has been carrying people to and from the Philippines since 1941. PAL has become one of the most respected airlines around the world with a young and modern fleet of aircraft and a route network that spans 31 foreign cities and 29 domestic points.
About IAE: IAE is a multinational aero engine consortium whose shareholders are comprised of Pratt & Whitney (NYSE: UTX), Pratt & Whitney Aero Engines International GmbH, Japanese Aero Engines Corporation and MTU Aero Engines. To date, more than 5,700 engines have been delivered and more than 1,600 more engines are on order with close to 200 customers around the world.


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Hello again!!
As all of you should know from my previous post, I'm a Aggressive Inline Rollerblader. And if you're a skateboarder, BMX rider or a roller like me, and if you travel to or is living in Singapore, and wanting to shred, THERE IS ONLY ONE PLACE TO GO. EAST COAST SKATE PARK. I'm not trying to brag about it but honestly and seriously, it is a WORLD CLASS skate park, worthy of your time and money just to travel here to have a session! I kid you not!
It has EVERYTHING any extreme sport enthusiast would want. An awesome street course with so much flow, a big and deep vert bowl, a combination bowl, curbs and ledges of all heights and length and even handrails! It is street and park fused into ONE location. What more can we ask for? And the ultimate part is…it's absolutely FREE!
Unfortunately, there is a flaw to it. It is the weather. Singapore is a tropical island. When there's tropical, there is rain. And boy do we get lots of it. It's very unpredictable as the skate park is located by the beach. Rain clouds tend to be blown over the area. It may be sunny one moment but before you know it, it starts to rain. But do not fret! It can rain buckets for hours on end, but once the last drop of rain hits the floor, give it 20-30 minutes and most of the park should have dried up!
The park is opened 24/7. Super hot in the day if it's not raining yet cool and breezy at night. There are flood lights that turn on at


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By Robert D. Thomas
Music Critic
Pasadena Star-News/San Gabriel Valley Tribune/Whittier Daily News
Long Beach Symphony; Enrique Arturo Diemecke, conductor
Terrace Theatre, Long Beach
Next concert: March 8
Information: www.lbso.org
For the past quarter-century the Long Beach Symphony has grown steadily in terms of artistic quality while, apparently, also achieving financial stability. In the process, it has consigned to ancient history a turbulent era that included cancelling most of the 1984-1985 season while the ensemble reorganized following bankruptcy.
In 1989 JoAnn Falletta began an acclaimed 12-year-tenure as the orchestra's music director before moving on to bigger vistas in Buffalo, New York and Virginia. In 2001 Enrique Arturo Diemecke, a dynamic Mexican conductor, succeeded Falletta and he has continued the orchestra's growth.
However, last November Diemecke — somewhat suddenly and mysteriously — announced that this current season would be his last. Beyond the original release, neither the orchestra nor Diemecke has said much about the decision. The orchestra has formed a search committee for a new music director and its recently announced 80th anniversary season in 2014-2015 will have each of the six concerts led by a different guest conductor, at least some of whom, presumably, could be candidates succeed Diemecke.
Meanwhile, the orchestra is trying to send Demiecke off with panache (the formal celebration will come in the last concert on May 31). Last night's concert featured him not only as a conductor but as a composer, since the final work on the program, Silvestre Revueltas' La Noche de los Mayas, features a cadenza for 12 percussionists that Diemecke wrote 15 years when he was conductor of the Orquesta Sinfónica Nacional de México.
In another nod to the birth centennial of English composer Benjamin Britten, the concert opened with an exuberant performance of Britten's Young Person's Guide to the Orchestra or, as it is sometimes called, Variations and Fugue on a Theme of Henry Purcell. The piece was also the centerpiece of the orchestra's free education program for youth, which took place during the week prior to the concert.
In the mid-17th century, Purcell composed incidental music to the play Abdelazar (The Moor's Revenge), and Britten used Purcell's hornpipe melody as the basis for music that he composed for a 1946 film entitled Instruments of the Orchestra.
Diemecke took the opening theme in a lush, stately manner, and the 13 variations showed off solo instruments and sections of the orchestra. The concluding fugue was brisk and built inexorably to a grand finale. Perhaps more than anything, the piece demonstrated the value of hearing music live, as opposed to via recording. Seeing and hearing the variations passed from one section to another added to the enjoyment.
Post-intermission, Diemecke and the orchestra offered a boisterous performance of La Noche de los Mayas, a piece that began as a score for a 1939 movie filmed in the jungles of the Yucatan and ancient Mayan ruins of Mexico. In 1960, composer-conductor José Yves Limatour created a four-movement suite from the film score and, with Diemecke's cadenza for the 12 percussionists who highlight the final movement, this is the version played by most ensembles today.
This is one of the few film scores that have made it into mainstream classical programs and it has been played by many Southern California orchestras, despite the resource required both in terms of extra percussionists and the instruments they play, which include a native log-like drum and a conch shell.
Diemecke, who was born in Mexico of German parents, clearly relishes this 36-minute work, and the orchestra rose to the challenge not only in the athletic portions but also in the lyrical moments during the two inner movements. As often happened, the audience sat stunned after the final cadence before erupting into a thunderous standing ovation.
Acting as a sandwich between the Britten and Revueltas pieces was Burleske for piano and orchestra, written when Richard Strauss was just 21 years old. If any orchestra has to program this vulgar, 17-minute piece then it might was well engage someone like pianist Alexandre Moutouzkine as soloist to make it at least endurable or, to most in the audience, enjoyable.
The 33-year-old Moutouzkine, who was born in Russia but completed a Master of Music at the Manhattan School of Music in New York City, has the kind of piston-like fingers that are indispensable in this piece, which program annotators Joseph and Elizabeth Kahn described as "a grand waltz fantasy in the flamboyant style of Franz Liszt." Actually, the way that Moutouzkine threw himself around the piano bench, one could easily have pictured a reincarnation of Liszt if Moutouzkine had the Hungarian composer's wild hairstyle. An enthusiastic standing ovation brought forth a jazzy encore that proved to be more of the same. One can only hope that there is more than pyrotechnics to Moutouzkine's musical makeup.
• Diemecke offered short commentary before each half of the program. His thick accent makes it hard for those who aren't concert regulars to understand him completely, but his infectious enthusiasm comes through clearly as it does on the podium, where he conducts without a baton, depending instead on whirling hands and bouncy athleticism.
The 2014-15 lineup of guest conductors includes
• John DeMain, formerly Music Director at Opera Pacific in Orange County who now leads the Madison (Wisconsin) Symphony Orchestra (Oct. 4);
• Santa Monica native Edwin Outwater, Music Director of the Kitchener-Waterloo Symphony in Ontario, Canada (Nov. 8);
• Bruce Kiesling, assistant conductor of the Pasadena Symphony who is also leading YOLA, the Los Angeles Philharmonic's Youth Orchestra of Los Angeles (Jan. 31, 2015;
• William Eddins, Music Director of the Edmonton Symphony (March 7, 2015);
• Lucas Richman, Music Director of the Knoxville Symphony and Bangor Symphony (April 25, 2015); and
• Edward Cumming, former Music Director of the Hartford Symphony (May 30, 2015).
Information: www.lbso.org
(c) Copyright 2014, Robert D. Thomas. All rights reserved. Portions may be quoted with attribution.


text: BRIDGEVIEW, Ill. Edinson Volquez Jersey . -- Sebastien Le Toux scored on a penalty kick in the 91st minute and the Philadelphia Union came back to tie the Chicago Fire 1-1 on Saturday. Le Toux was awarded the penalty kick after Gonzalo Segares was called for a hand ball inside the penalty area. Segares turned his back on Le Touxs shot, but the ball hit his right arm. Le Toux calmly slotted home the penalty kick inside the left post, past a diving Sean Johnson. He has scored five goals in his past six games for Philadelphia (5-8-8). Jeff Larentowicz headed home a corner kick from Harrison Shipp in the 60th minute for a 1-0 lead for Chicago (3-4-11). The duo failed to convert a similar play in the 37th minute when Larentowiczs header was just high of the crossbar. Neither team had a player selected for the MLS All-Star game when the rosters were announced Saturday. Custom Kansas City Royals Jersey .J. -- The New Jersey Devils are so bad in shootouts, coach Pete DeBoer doesnt mind seeing his team take chances in the five-minute overtime. Wade Davis Royals Jersey . The group of Slava Fetisov, Igor Larionov, Vladimir Konstantinov, Sergei Fedorov, & Slava Kozlov were a dominant force for The Wings at one point in the 90s. http://www.authentickcroyalsprostore.us/Edinson-Volquez-royals-jersey/ . They find themselves trying to knock each other out in the Western Conference finals for the second straight year. The Blackhawks prevailed last year on their way to the Stanley Cup, and they have the early lead this time after taking the opener, 3-1. CHICAGO -- It didnt matter much to Anthony Rizzo that the Chicago Cubs finally swept a series. Winning three straight? Thats what registered with him. Rizzo hit a tiebreaking homer, Travis Wood went deep and drove in three runs, and the Chicago Cubs beat the New York Mets 7-4 Thursday night to complete the three-game sweep. Rizzos solo drive off Vic Black (1-1) with one out in the seventh gave the Chicago a lead after they wasted a four-run lead. Andrew Browns two-run shot tied it 4-all in the top half. Junior Lake added a two-run triple in the eighth, and the Cubs came away with their first series sweep since they took three at San Francisco last July 26-28. "I know we won three games in a row, whether its a sweep or not," Rizzo said. "Its just nice to win ... especially in a series where we played good baseball." Wood delivered in a big way at the plate and was in line for the win before New York rallied from a 4-0 deficit. He hit a two-run homer in the second off Jacob deGrom after Luis Valbuena was ruled safe at home on a sacrifice fly to left following a replay review on what would have been the third out to give Chicago a 3-0 lead. And Wood drove in another run with a fielders choice grounder in the fourth. "I feel like were commanded to hit in this league, so you want to try to be as best as you can," said Wood, who has two homers this season and eight in his career. The Mets scored two while chasing Wood in the sixth and tied it in the seventh when Brown, who was recalled from Triple-A earlier in the day, connected off Justin Grimm. Rizzo, however, put the Cubs back on top with a long drive to right-centre on a 3-1 pitch for his team-leading 11th homer. Grimm (2-2) got the win. Pedro Strop stranded two runners in the eighth before Lake made it a three-run game in the bottom half. Neil Ramirez then converted his first save opportunity, retiring the side in the ninth, and the Cubs swept three from New York at Wrigley Field for the first time since April 2004. The Mets went 2 for 13 with runners in scoring position and stranded 11 runners after leaving 10 onn in each of the previous two games. Jarrod Dyson Royals Jersey. It added up to a sweep by a team with the worst record in the National League. "When they all got big league uniforms on, theyre major leaguers," New York manager Terry Collins said. "Theyre trying to beat you just as much as youre trying to beat them. Once in a while they play good, you dont play good, youre gonna get your butt kicked. Thats the way it is, thats just the way it is around here." They wasted several opportunities against Wood, who gave up two runs and five hits in five-plus innings. He tied a season high with five walks but kept pitching out of trouble until the Mets knocked him out in the sixth. He left with a run in after giving up a leadoff walk to Brown and back-to-back singles by Wilmer Flores and Ruben Tejada. Young added an RBI single off Brian Schlitter with two out, cutting it to 4-2, before Curtis Granderson popped out to end the rally. DeGrom gave up four runs and five hits over five innings and remained winless in five starts for New York. NOTES: The Cubs observed a moment of silence before the game for Don Zimmer, who managed the 1989 team to the NL East crown. Zimmer spent 66 years in pro baseball and was still working as a senior adviser for the Tampa Bay Rays before he died Wednesday at 83. He had been in a Florida rehab centre since heart surgery in mid-April. "I lived in St. Petersburg for 12 years, so I saw Don a lot," Collins said. "Its a sad day for baseball. One of the truly iconic baseball personalities in the game. I grew up a Dodgers fan and this guy was one of the great Dodgers. If it wasnt for Pee Wee (Reese) he would have had a tremendous career." ... Mets prized pitching prospect Noah Syndergaard left Thursdays start for Triple-A Las Vegas after experiencing discomfort in his left shoulder following a tag play at the plate. New York said he had precautionary X-rays and the results are pending. It was his first start after returning from the DL because of a mild strain in his right elbow. ... Chicago took Indiana C-OF Kyle Schwarber with the fourth pick in the draft. Wholesale Jerseys Cheap Jerseys From China Wholesale Jerseys 2018 Cheap Jerseys Cheap NFL Jerseys Authentic Wholesale Nike NFL Jerseys NFL Jerseys China ' ' '


text:
It's 2010 – Time For Another Visit to THE Cabin…
THE EVIL DEAD Blu-ray™
HD bow of horror classic includes two new HD transfers
personally supervised by writer/director Sam Raimi
and an all-new audio commentary
BEVERLY HILLS, CA – Easily one of the most requested titles for Blu-ray™ from Anchor Bay Entertainment's unparalleled library of horror films, Sam Raimi's 1981 cult classic The Evil Dead will officially make its high definition debut on August 31st with The Evil Dead Blu-ray™. For the release, two all-new 1080p anamorphic transfers in 1.85 and the original director-composed 1.33 aspect ratio, have been prepared and personally supervised by director/writer Raimi, presented in high-resolution Dolby TrueHD 5.1 audio, as well as a brand new commentary track with Raimi, producer Robert Tapert and star Bruce "Ash" Campbell! In addition, many of the bonus features, released on previous DVD editions, will once again be available on a special, limited edition DVD included with the Blu-ray™. SRP is a very collectible $29.99 and pre-book is August 4th.
The Evil Dead is one of the most influential, landmark horror films of all time. Five college friends, including Ash (Campbell), drive to a remote cabin in the woods for a weekend of fun. Little do they realize that their fun will soon turn to fear, as an unstoppable supernatural force has been unleashed, surrounding and trapping them. One by one, they fall victim to the demonic forces at large, resurrected as murderous demons which can only be destroyed by dismemberment. Only Ash is left to combat the evil before it consumes the world. It'll be a fight to the death … and to the undeath.
The Evil Dead Blu-ray™ (Disc 1) contains an all-NEW audio commentary with
Writer/Director Sam Raimi, Producer Robert Tapert and Star Bruce Campbell. A
standard DVD (Disc 2) contains the following bonus features, many returning for
the first time in years, and available only for a limited time:
- One By One We Will Take You: The Untold Saga of The Evil Dead
- The Evil Dead: Treasures from the Cutting Room Floor
- The Ladies Of The Evil Dead Meet Bruce Campbell
- Book of The Dead: The Other Pages
- Discovering The Evil Dead
- Unconventional
- At The Drive-In
So pick up The Evil Dead on Blu-ray™, steal away to your favorite secluded cabin and see this horror classic like you've never seen it before!


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That is ridiculous and a lie. You should know better.
My firend Mathew.It is true the Rusian diaspora church has no comunion with the most other churches.Actually The Vatican has more comunion with orthodox churches than the Russian Diasppora church, but that does not mean that Vatican are more orthodox than Russians.
Such might be the case with St.John of San Francisco. Also I think this may apply to current day Romania. St.Glicherie of the Romanian Old Calendarists and Elder, hopefully soon-to-be-Glorified, Cleopa of the New Calendarists on the other side. As I always try to tell people within Orthodoxy things are not so cut and dry.
Bishop Artemije of the Serbian Patriarchate was only rumoured to have met with Metropolitan Cyprian of the G.S.R. and is now barred from entering Constantinople on the orders of Patriarch Bartholomew II.
I think you mean heretical since all Orthodox jurisdictions still view Chalcedon as Ecumenical. That is not to say I think that the Oriental churches will never return to Orthodoxy but for now they are still considered heretical. Pope John Paul II was a beacon of sanctity to some people but I do not think he was an Orthodox Saint.
The Antiochian Church is in full communion with the Oriental Orthodox Churches and considers us neither schismatic nor heretical.
Either way, I'd perhaps prefer to be Russian Orthodox, given that it seems to be the most traditional of the Orthodox Churches.
I do not mind accepting Chalcedon but I definitely would not allow myself to be "re-baptized".
The Greek Orthodox and Antiochian churches in my town have intercommunion with my church.
Only hardlining anti-OE congregations find our Church to be heretical.
It is not that ridiculous. We believe that Christ is fully divine and fully human and thus we are not guilty of monophysitism.
Furthermore, there is ecumenism between the Antiochian and Greek churches in my town with my church. We are allowed to receive communion at the EO churches in Spokane and vise versa.
The reality is, Chalcedon is an Ecumenical Council of the Church, and those who reject it are heretics, whether they be malicious or not.
How many people consist the ROCOR currently?
Could someone please explain why the ROCOR and OCA are separate churches and why there is such hostility between them?
I've heard that the ROCOR is much more conservative and that the members of the OCA greatly disliked Fr. Seraphim Rose.
Well...Why isn't ROCOR in communion with Moscow also? And why aren't ROCOR and the OCA one church?
Why isn't ROCOR in communion with Moscow also
And why aren't ROCOR and the OCA one church?
Michael,The OCA and ROCOR are not in official communion, as in clergy and hierarchs don't concelebrate, but most (or maybe just "many") priests will communion each other's faithful, although the ROCOR priests will usually require a confession during the prior week. In a mathematical sense (as you described below), they are actually are in communion - through the Serbs and Jerusalem. These two Churches are in communion with ROCOR and thus by extension everybody else, hence the confusion.
What would there be to confess?
Many ROCOR churches still hold to the practice of requiring that one go to confession before partaking of the Eucharist.
And rightfullyl so...
Don't believe everything you think.
The more I know, the less I know.
I thought you meant confessing a heresy.
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Hillel welcomes students of all backgrounds and fosters an enduring commitment to Jewish life, learning and Israel. As the largest Jewish student organization in the world, Hillel builds connections with emerging adults and inspires them to direct their own Jewish journey.
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Passover is the most celebrated Jewish holiday throughout the world, commemorating the Israelites' exodus from a life of slavery in Egypt to freedom. On the first two nights of Passover, many Jews hold a seder (literally 'order'), consisting of a series of readings and rituals, and we retell the Passover story. The seder is an annual Jewish ritual in which groups of people—families, friends, communities, and even groups of strangers—gather for a time of reflective conversation about freedom.
A Freedom Themed Passover in Israel
Hillel Israel celebrated Passover with the children of migrant workers to highlight the values of freedom and liberty. Israeli students joined with the Kibbutzim Seminary's student union at a unique event that combined elements of the traditional seder with material relevant to the children's lives, emphasizing the themes of freedom and liberty. The children shared their families' personal story of the journey to freedom with their Israeli hosts.
"This event cast Passover in contemporary terms, making it relevant to young Israelis and underscoring Hillel Israel's desire to promote Jewish renewal and communal responsibility among our students," said David Ya'ari, then CEO of Hillel Israel.
Asking Big Questions:
If you're hosting your own seder, check out our Passover guide!
Our award-winning Ask Big Questions initiative gives students the opportunity to have conversations about topics that matter to everyone, in order to understand each other, understand ourselves, and make the world a better place.
With that in mind, we created the "Are we free?" Passover guide to inspire conversation and create understanding among Jewish students – and all seder participants – about the big questions concerning freedom's meaning, for what they are thankful and for whom they are responsible. The guide can help make the Passover ritual one that will deepen students' connection to Judaism, our people and our practice. Download it here (PDF).
Hillel International


text:
October 16, 2006
We had a great initial WABASH Day in Houston. The project with the Hermann Park Conservancy turned out to be a great project for our alumni group. The location of Hermann Park is centrally located for all alums in the area, and the statue of Sam Houston is a well-known landmark easily located by everyone ... no need for me to send mapquest directions to everyone!
The extent of the work was perfect for our crew. The area around the base of the statue they wanted us to clean up was a real mess when we started - grown over and full of dead growth of flowering bushes that had finished blooming for the year. We all felt a real sense of pride 4 hours later marveling at what we had been able to accomplish and how much nicer the area looked because of our efforts.
The work lent itself to working together and being able to converse while working. I think everyone had a great time. If we all weren't so dang busy and overcommitted we could have hung out talking afterwards for hours. Everyone left talking about when we could get together next.
Of special note is that Tony Goodwyn and Michael Quach arrived for the work day not knowing that the other was going to be there. The two TKE brothers also did not know that they were both living in Houston!
It was a fun reunion for the two of them, catching up with what they have been doing since leaving Wabash. They both seemed very happy to reconnect after all most 10 years without seeing each other.
I saw the Montgomery County pictures with all the sweatshirts and winter coats and talk of the morning chill. In Houston we were working in shorts and t-shirts, and left for home very sweaty, dirty, and even a little bloody from some of thorny bushes in the work area. Blood makes the grass grow greener, greener!! Go Wabash!!
Here's the list of participants: Larry Knauf '62, Gary Parks '73, Greg Birk '77, Joe Higgs '79, Jim Cooper '81, Michael Quach '97, Tony Goodwyn '00, Ben Cooper '15 (8th grader son of Jim Cooper '81).
In Photos: Front row: Gary Parks '73, Jim Cooper '81, Tony Goodwyn' 00. Back Row: Joe Higgs '79 Greg Birk '77, Larry Knauf '62, Ben Cooper '15. In center photo: TKE brothers Goodwyn and Quach. At bottom right: Joe Higgs, being supervised by Sam Houston!


text:
A new poll by McClatchy/Marist finds that most Americans — including those on the low end of the income spectrum — favor keeping the Bush tax cuts in place for all Americans. According to the poll, 52 percent of registered voters say they want all of these tax cuts extended, including those for incomes above $250,000. 43 percent want the cuts extended just for incomes below that threshhold.
The results are essentially the same for voters at the lower end of the income spectrum. Those making less than $50,000 per year supported tax cuts for all incomes by 53 percent to 41 percent.
Whites and Hispanics both want to see the tax cuts for everyone, with Hispanics favoring this position more than whites. African-Americans were evenly divided.
Perhaps the most striking result was among voters ages 18-29. They favor tax cuts for everyone by a margin of 69-29, the largest margin of any age group.
Maybe there is hope for this country after all.


text:
Internet problems at home have prevented me from posting, so after a 5-day delay, I can finally say that Encephalon #57 is up at Mind Hacks. It's an excellent compilation as usual, with posts on infantile amnesia, long-term potentiation and memory erasing particularly catching my eye.
I've not been posting much recently (have spent my days recently sitting in front of a screen attempting to programme an embodied developmental-like cognitive architecture, so sitting in front of a screen any more to write and post on the blog hasn't really been in the forefront of my mind), but in the coming week, watch out for posts on pain (and its developmental role), and perhaps also one on the mirror neuron debate.


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Dec. 4. 9000 block Germantown Avenue. Complainant states that a known male came into her room and forced her onto bed and raped her. Reported at 2:30 a.m.
Dec. 8. 7700 block Crittenden Street. Complainant states that she was walking southbound on Crittenden when an unknown person came up to her from behind and grabbed her purse off her shoulder, then got into a silver SUV with possible Pennsylvania tag HWP 7085. Occurred at 4:45 p.m.
Summary — Two crimes for week: one rape and one robbery.
Town Watch.
If you have been the victim of a crime and would like information, service or support, call Northwest Victims Service, 6301 Germantown Ave., Second Floor, Suite One, 215-438-440. The service is free.


text:
Express. Home of the Daily and Sunday Express.
Bantams brought back to earth
Just a week after defeating Arsenal in the Capital One Cup, Bradford lost their FA Cup second-round replay against Brentford in extra-time.
The npower League Two side, reinstated to the competition on appeal after initially being thrown out for fielding an ineligible player, held their League One opponents to a 1-1 draw at the end of normal time before they eventually went down 4-2.
Kyel Reid's opener was followed by a Marcello Trotta penalty on the cusp of half-time before a scoring splurge in the added half-hour. Alan Connell put Bradford ahead from the spot four minutes after the resumption only for Trotta, Clayton Donaldson and Harry Forrester to all score with within four minutes to send the Bees through to a meeting with Southend.
Fourth-tier Rotherham are through to face Aldershot following a 3-0 win over 10-man Notts County.
Ben Pringle and Mark Bradley had already scored before Damion Stewart's red card on the half-hour and Daniel Nardiello completed the scoring four minutes from half-time.
Oxford also represent League Two in the next round after they lined up a clash against Sheffield United by seeing off Accrington 2-0.
James Constable and Peter Leven were the scorers.
Blue Square Bet Premier rivals Barrow and Macclesfield must meet again for the right to host Cardiff after a 1-1 draw.
Kieran Charnock put Macclesfield in front in the 19th minute, with Richie Baker levelling 10 minutes later.


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Android Games – Action and Adventure
Zombie Fish« Games - Arcade & Action « Downloads
|October 18, 2014
|5 times
|Games - Arcade & Action
|art, arts, bird, birds, cap, copter, copters, dong, flappy, flight, flights, game, games, handle, handles, hard, hat, hats, helicopter, nguyen, pixel, retro, sport, sports, super, swing, flappy bird, super hard, chen, copter game hd, free copter, swing by swing, swing pro, a bird, a cute, avoid the, avoid, a monster, fast, cute, bored, flies, fly, fun for kids, fun kids, jet, jets, kids fun, monster, monsters, pig, pigs, quick, reflex, reflexes, the birds, touch, a jet, free great, free bird, game great, games great, great free, great game, great play, mars, mats, no ads, noads, pipe free, pipe, pipes, pipes hd, pipes pro, ninja ninja, ninja, a tiny, ninjas, animais, bird tap, bird game, fly-ing, flying bird, bird bird bird, flying game, fly bird, fly birds, bird fly, fly game, swing fly, fly copter, zombie
The bird fly with a propeller now ! Please help it avoid the obstacles above and let it fly higher. You can see your rank in Game Center. Enjoy the game !


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Hi KathyMichelle,
Sad news indeed. So sorry to hear of her traumatic situation. It is great to know she came through the surgery, I'm sure she'll be happy to see you when you're able to return. My thoughts and prayers are w/her for a successful recovery.
Take care, hope your appt w/the new NS went well.


text:
Wax on Wax off
Certain players have improved this season, talent helps of course, but think TC and his staff deserve praise for it.
Ronaldo Vieira- Seems more confident, looks stronger and fitter, TC seems to have given him more freedom, primarily a defensive midfielder, under Monk that was it, but this season we have seen him breaking forward and starting our attacks, its nice to see because he is a real powerful runner.
Kalvin Phillips- Similar to Vieira, under Monk he was stifled, protect the back 4 was his role. TC has encouraged him to get forward, at times he is up front. His passing is improving and he to also seems fitter, he and Vieira compliment each other well and cover for each other when needed, good coaching.
Liam Cooper- Not a fan, but credit where its due. He has shown confidence bringing the ball out of defence, he seems a bit more comfortable with the ball at his feet, and in recent games he has been solid and is showing a bit of consistency.
Kemar Roofe- I remain unconvinced, but theres no question he has improved this season. His movement and link up play is better and he is showing signs of adapting properly to the league. Think TC deserves credit for this as its known he does like to work with the attacking players. And although not entirely comfortable on the wings, he has shown a willingness to try to be positive and rotate with Saiz and Ali similar to Pablo.
Pablo Hernandez- His workrate is so much better, his willingness to track back and "put a shift in" is vastly improved on last season. He isnt naturally a hard working player, but he has pressed and tracked back well mostly this season. Also, think he looked a bit uncomfortable out wide early season, been a few years since he was a winger and struggled to adapt. Often coming inside to much and making us to narrow. Recently, he has stuck wide more, helping to make the pitch as wide as possible, which given our playing style is important.
Is there anyone else who should be on the list?
TC = Mr Miyagi
For everything Leeds United related and everything not - Have your say... the Marching on Together way!
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SPRINGFIELD-- Longtime police union attorney Kevin Coyle is arguing for the dismissal of a high-profile lawsuit leveled earlier this year by former narcotics detective Steven Vigneault.
Coyle is arguing he enjoys blanket immunity under laws designed to deter union busting, according to attorney Denise M. Tremblay. She argued on behalf of Coyle during a hearing in Hampden Superior Court Tuesday.
Neither Coyle nor Vigneault was in the courtroom during the proceeding.
Lawsuit by former Springfield detective alleges on-the-job drunkenness by fellow officer
Former Springfield Police detective Steven Vigneault has filed a whistleblower lawsuit alleging a onetime colleague regularly drank on the job before drug raids.
Judge Constance M. Sweeney questioned how any attorney could deflect allegations of legal malpractice under every conceivable circumstance.
"This questions whether immunity is applicable for any potential sin," Sweeney remarked from the bench during a motion for summary judgment-- which if successful, would free Coyle as a defendant in the case.
"That's what the law says," Tremblay told Sweeney, citing legal precedents including Best v. Rome, a 1994 federal case involving a dispute by a former Boston Police employee.
Vigneault--who contends he was pressured to resign from the police force amid a controversy in 2016 by the union and Commissioner John Barbieri-- filed a whistleblower lawsuit in late January. In the complaint, he names Coyle, the city, and police officers including the commissioner. Vigneault argues other officers, namely Officer Gregg Bigda, got passes on unseemly or criminal behavior while he was duped into quitting.
In his lawsuit, Vigneault argues he received bad advice from Coyle and his union representative. He also accused co-workers of on-the-job drunkenness, bullying and other misdeeds.
Patrolman's union President Joseph Gentile and the union have been dropped from the case under the immunity argument. The other defendants remain.
Vigneault has emerged as a complicated figure in parallel state and federal investigations. His complaints against the police department have given rise to an FBI civil rights probe in which Vigneault is a witness.
Whether we serve in Primary or Young Women, whether we're active or less so, whether we're married or single, whether we're spring chickens or fall hens, we all belong to Relief Society. I'm a fall hen, but I feel like a spring chicken! We need your voices, your feelings, your hearts. Relief Society needs you. And you know what? You need Relief Society. When you don't participate, you're depriving yourself and you're depriving Relief Society.
Sisters, we can have no divisions in Relief Society; all "members should have the same care one for another." 9 "And whether one member suffer, all the members suffer with it; or one member be honoured, all the members rejoice with it." 10 For "the body hath need of every member, that all may be edified together, that the system may be kept perfect." 11
Yes, Relief Society can be more fun, more joyful, more unifying. Our burdens can be lightened, our loads lessened. Relief Society's not perfect, because not one of us is. But we can work on it; we can perfect it together as we take our own steps forward. How? By just changing our attitudes: How we talk about Relief Society affects how others feel about Relief Society—especially young women.
Be supportive of our Relief Society presidencies and teachers—let them learn on our time (just as we will learn on theirs). Forgive more and judge less. Be a caring, consistent visiting teacher. Attend home, family, and personal enrichment meeting with enthusiasm. Look for what's good about Relief Society and build on it.
President Joseph F. Smith issued a charge that we "take hold of this work [of Relief Society] with vigor, with intelligence and unitedly, for the building up of Zion."
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If we believe that the Lord's Church has been restored—and we do—then we must believe that Relief Society is an essential part of His organizational fold. We need to stop asking whether we fit—because we do! Our differences are not so great that we cannot build Zion together.
Nearly a year ago, in Pasadena, California, Sister Janice Burgoyne was dying of cancer. She had shared generously of herself and was dearly loved. Her Relief Society sisters were bringing her meals, cleaning her house, caring for her two young sons, helping her husband plan a funeral. It was hard for Janice to receive so much help, knowing that her sisters would find that piece of old toast behind the couch. She worried her sisters would know more than her heart. But because her sisters knew her heart, it didn't matter. They provided car pools, tutored homework, played her piano, changed bedding. And they did it day after day after day, without complaint, with boundless charity. Such sharing forever changed those sisters. Before she died, Janice turned to a Relief Society sister and asked with gratitude and awe, "How does anyone die without Relief Society?"


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Vatican documents don't spend equal time on the assembly line.
Next Tuesday, the Congregation for Catholic Education is issuing a text on how religious and lay people share responsibilities in Catholic schools. The wider role of lay teachers is apparent to anyone familiar with church-run schools, and it's been under discussion at the Vatican for the last couple of years.
But another document has been waiting in the wings at the education congregation for at least eight years — and it may not see center stage anytime soon. It's on a trickier topic: the use of psychological sciences in seminary selection and training. Inside the Vatican, just the term "psychological testing" can sometimes start a heated debate.
Back in 1998, Pope John Paul II asked the congregation to draft guidelines on how psychological sciences can help "discern and promote maturity" among seminary candidates and seminarians. But some Vatican officials are wary of such testing and say it could be easily abused. A judgment on someone's vocation, they say, cannot be reduced to a psychological assessment.
In 2002, CNS was told that the guidelines on psychological testing were just about ready to roll out. But something happened on the way to final approval. Enough doubts were raised that another five years of study was needed. In the meantime, the congregation gave more urgent attention to a document against admitting homosexuals to the priesthood, issued with much fanfare in 2005. Some thought that made the psychological testing document even more important.
When I've asked Vatican sources about the delay on psychological testing guidelines, they've told me the text has been "reformulated and restructured" in the light of consultation with in-house and outside experts. One problem, they say, is that the Vatican is expected to issue a universal document to fit all seminaries, but the situations in seminaries — and psychological resources — vary greatly from country to country. Psychological testing also touches on the sensitive issue of human rights, in particular the right to privacy, and that's also been debated at length.
The Vatican doesn't usually announce the progress (or lack of it) of documents under preparation. That's one reason why the CNS Rome bureau lays out $100 each year to purchase a thick book called "Activity of the Holy See," which includes annual reports from Roman Curia agencies. I opened the most recent edition and, turning to the Congregation for Catholic Education, read that the document on psychological sciences was still being worked on.
Then I made a phone call and found out the congregation plans to discuss the latest draft of the document at its plenary session in January. Is the finish line in sight?
"We hope so," my source said. Then, lest he whet journalistic appetites, he added quickly: "Of course, we're not sure about that."


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This washer has not been a very dependable washer. I have already replaced the bearing to remove the jet airplane noise. Now I am having inconsistency issues with the spin cycle. The washer will actually spin for one load and then the next load it won't. When this happens we repeat the "spin" cycle up to 10 times before it actually spins again. It "agitates" fine and the water drains properly. However, it will not spin to remove the water in the clothes. I can hear the timer click. I have seen the other postings about the control board and the R-11 resister is not burned. Does my control board need replacing, or is it the timer?
Thank you all for your help. I did replace the belt when I replaced the two bearings.It appears that the vertical spin switch on the door lock is the issue. I reset the spring to no avail and then crossed the switch and now I have spinning but I have no "beeping noise" when the load is finished and the "on" light does not automatically go off - I am attributing this to bypassing the spin switch. The only issue I have is that I am unable to determine if the spin switch is bad or if a piece of the door wax motor is not pushing in the black button on the spin switch.


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Originally Posted by HutchEmAll: Broyles will be the number 2 guy this weekend, but he's had one really good game and hasn't scored since week 8. Colston is pretty consistent to throw on the bench.
Broyles should be good the rest of the way. Last week was the first game he started...doesn't make a lot of sense to focus on before that. I'd role w/Broyles this week. In fact, I'm going to most likely over Blackmon.


text:
So. You want to know how to build a simple localization system in C# and WPF? No problem! That is what this tutorial is for.
In this tutorial I will describe my favoured method of localization using XmlDataProvider.
What Do I Need?
All you need for this are a WPF C# project (though you are welcome to port it to other languages if you want)! That's it. I'm using a .NET 4.0 language for this but you can use others if you wish.
Step 1 - Your XML File:
First you need to add a new directory to your project, you can call it whatever you like but I called mine "languages". Next, inside this file you need to add a new item, an XML file. This will hold your language data. Here is a portion of the XML file used for CSIT:
xml Code:
- <?xml version="1.0" encoding="utf-8"?>
- <CSIT for="1.*" name="English">
- <!-- Remember. For menu items the character following the underscore (_) character will be set as the menu accelerator key. -->
- <MenuItems>
- <MenuFile Header="_File" />
- <MenuExit Header="E_xit" />
- <MenuTools Header="_Tools" />
- <MenuOptions Header="_Options..." />
- <MenuHelp Header="_Help" />
- <MenuAbout Header="_About..." />
- </MenuItems>
Not to bad eh? As you can see - your standard XML file. You can use whatever layout elements you like, you do not have to use the same structure as mine.
Now. Once you are done setting up your XML file, name it something like en.xml or whatever language code you are using. Be sure to set the build action of this file to "content" and "copy if newer". This is quite important since if you set these these incorrectly the file will not get copies and updated when you build your program.
Now. The next stage is to link this file into the program so it can be used.
Stage 2 - Linking the Documents:
Thankfully XAML provides a nice easy way of representing this kind of link - a binding. Not all things can be easily bound but most things can.
You will need to add the following code to your App.xaml document - this will make localizing the whole application much simpler. The code you need is as follows:
xml Code:
- <Application.Resources>
- <XmlDataProvider x:Key="Language" Source="/languages/en.xml" XPath="CSIT"/>
- </Application.Resources>
As you can see. I added mine into the application resources - just to save adding it to each window (since my app has quite a few!).
A few things to note here, the x:Key represents the ID by which we will access this element later. The source you will need to customize to be the relative location of the XML file to your application.
Finally, the XPath attribute. You should set this to the root element in your XML document, which in my case was "CSIT".
So now. You already have the XML document and the basic linking - not bad for a start. But our work is not done yet - now we need to use the information from the XML file in the program via bindings.
Stage 3 - Data Bindings
I guess by now, if you have been using WPF and C# you already know about bindings and since this tutorial is about localization I will not dwell on it since there are probably other tutorials on here for that already. Here is an example of how I used the above binding code in my application:
I've bolded the bits that we are interested in. These are binding references. Note that we are using the key for the XmlDataProvider that I described earlier.Code:<Menu IsMainMenu="True" Margin="5"> <MenuItem> <MenuItem.Header> <AccessText Text="{Binding Source={StaticResource Language}, XPath=MenuItems/MenuFile/@Header}" /> </MenuItem.Header> <MenuItem Click="MainWindowExit"> <MenuItem.Header> <AccessText Text="{Binding Source={StaticResource Language}, XPath=MenuItems/MenuExit/@Header}" /> </MenuItem.Header> </MenuItem> </MenuItem> </Menu>
The XPath is what we are interested in here - this is the path, relative to the XPath attribute designed in the main XmlDataProvider element I designed earlier. The item with the at sign (@) prefix represents an attribute which should have its value will be read. So. For the first item above, the resulting menu will show as "File". Simple eh?
Stage 4 - The Language Framework
So. We now have a language binding that works - but it's not quite there yet since we can't change languages and without that what good is a localization framework?
For this next part we will need more code - and luckily I already have the code for it written. The code is attached.
This code handles most of the work for you. If you do not want the language version compatibility code, feel free to remove it however I found it useful when working with varying program versions.
In App.xaml.cs add the following code:
csharp Code:
- /// <summary>
- /// This will handle the languages and language changes.
- /// </summary>
- public static LanguageHandler LanguageHandler = new LanguageHandler();
... and this will handle the language changes over the whole program. In the starting windows initialization function I added the following code:
csharp Code:
- // Add a language changed listner.
- App.LanguageHandler.LanguageChanged += new LanguageHandler.LanguageUpdatedHandler(UpdateLanguage);
- // Set the language to the default - English.
- try
- {
- App.LanguageHandler.SetLanguageResource("en");
- }
- catch (Exception ex)
- {
- System.Windows.MessageBox.Show("Language resource could not be set!");
- return;
- }
Strictly speaking I didn't need to call this here given what I have shown you so far - however there are reasons that I will explain below.
In some occasions there may be items where you have strings that cannot be bound to directly - this is the reason for the event handler. The event handler fires when the language changes and causes a function to be run - in this case the following code:
csharp Code:
- /// <summary>
- /// This will cause the special localizable strings to be updated. Those that cannot be directly bound
- /// with data bindings.
- /// </summary>
- private void UpdateLanguage(object sender, LanguageUpdatedArgs e)
- {
- this.statusBarStatus.Content = App.LanguageHandler.GetLocalizedString("StatusWelcomeString");
- }
So. This can be used for any items that need to be set dynamically when the changes are made. In my application for example strings need to be checked and changed at varying places.
Just remember that if you are doing to use the language handler file I included, you will also need to change this line:
...And include the new root element in there too or else it will not work!Code:strings = languageInfoFile.Element("CSIT").Element("Strings").Elements("String");
Hopefully that will provide a nice introduction to localization - or at least my method of it. If anyone has any comments, suggestions or improvements feel free to share them!
Thanks for reading.


text:
Switching the Bait
Turning a standard technique into an unbiased screen for diagnostic biomarkers
Feb 1, 2012
Edyta Zielinska
Screening for antibody biomarkers of disease to facilitate diagnosis has been fraught with failure, despite its logical approach: stick proteins onto a microscope slide and then pour over a patient's serum, full of disease-specific antibodies, and see what sticks. Compare the results to the serum of a healthy person, and you've got an antibody-protein pair that should signal disease. But of the proteins IDed employing that method, "none of them are even close" to clinical diagnosis, says Thomas Kodadek, at the Scripps Research Institute in Jupiter, Florida. Kodadek and his colleagues figured that the antibodies in the serum of an ill individual wouldn't be likely to bind to normal biological proteins. The immune system recognizes the foreign proteins of an invading pathogen or the markers of a dying cell precisely because they are different from the body's normal proteins. A cell involved in a disease like cancer or Alzheimer's is more likely to produce altered proteins, either because of genetic mutations or because the disease process changes the cytoplasmic environment, causing unexpected posttranslational changes.
But trying to guess what those chemical alterations might be is difficult. "We have absolutely no freakin' idea what those events are," says Kodadek. So instead of coating the slide with known proteins, Kodadek coated a glass slide with a fairly random assortment of unrelated synthetic small molecules that bind serum antibodies simply because of their chemical shapes, allowing for a broad and unbiased search. "The difference is what you're fishing with," he says.
The method "represents a major advance in the field," says Bill Robinson of the Stanford University School of Medicine. "It could enable the identification of the antigen targets for multiple autoimmune and other diseases."(Cell, 144:132-42, 2011)
|Comparing Methods:
|Unaltered protein
|Glass slide with proteins
|$1,500 (commercially made slides)
|Several thousand per slide
|Synthetic molecule
|Glass slide with small molecules
|$10 (lab-made slides)
|Potentially millions (if beads are used in place of slides)