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Guided Private Photo Tours in Rome, Florence, Tuscany & Venice
Imaging In Italy is a great program for anyone who wants to learn to make great images. Boccaccio's unique style, his way of seeing the world and capturing it on film is what most impressed us at Geographic. I can't think of a more qualified person to mentor his photographers in the art of seeing, particularly as it relates to photography!
- Jack Fletcher National Geographic Magazine
Rome is more than inanimate monuments and marble statues. It is a vivacious city shaped over the ages by emperors, artists, and architects who, in building the Eternal City, fashioned a remarkable human story where gods, angels, and demons lived. We offer a variety of tours to suit your needs and schedule. Read & See More!
There are few places on earth as beautiful and captivating than Tuscany's Chianti wine country. We'll visit some of the region's most iconic spots and while photography is the primary goal, this tour will be a cultural journey that will inspire and enrich all of your senses. You'll see and photography iconic architecture, rich and textured landscapes, charming hillside villages, famous cathedrals adorned with some of Italy's most enduring Renaissance art, and of course, delicious food and wine. Read & See More!
Florence is the birthplace of the Renaissance and is perhaps one of the most visited cities in the world. Our photographer will show you Ponte Vecchio, Piazza Signoria, Palazzo Vecchio, Il Duomo, Doors of Paradise, the Arno River, statues of the Loggia, and panoramas of Florence. Read & See More!
Venice is a World Heritage site, and for good reason. On this tour, you will move around and photograph Venice with your guide at your side, not as a tourist but as a Venetian. Explore and photograph the labyrinth of waterways, the markets, the piazzas and the mysterious and hidden places only Venice has to offer. Read & See More!
Celebrate an anniversary, wedding or other special occasion in Rome, Florence, and Venice. Let our expert bilingual photographers capture these memories forever. They will lead you to the great monuments as well as some of the hidden parts of your city. You will explore not as tourists but as an Italian - and our photographer will capture the spontaneous emotions and memorable expressions that really tell your story. Read & See More!
Our itineraries are not run-of-the-mill. Each tour is specifically designed to insure that you will see and photograph the most interesting and important places each city has to offer. Our photographers know their respective cities intimately, and are ready to offer not only photographic coaching, but an interesting commentary on those places you will be photographing.
Our goal is to show you how to "get the story behind the image" - not just a collection of post-card photos. At the end of your tour, you will take home a fantastic collection of captivating photographs that tell YOUR story, the way you experienced the places you so looked forward to knowing and photographing.


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ATR Resumes
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Sharon on 18th May 2011
Accent Resumes
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subset: commoncrawl


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Tagged: Bob Ueker
Slicin' It Pretty Thin and Havin' Fun
As much as I want to hate the Milwaukee Brewers right now, I'm finding it very difficult to criticize their style of play. How can I?!? These dudes are MACHINES!
They are getting sound pitching from both their starters and their pen. They catch the ball. They make all the routine plays. And boy can those Brewers hit.
But perhaps the best part of the Brewer's m.o. is that they're unconventional. I mean, Prince Fielder is fat. I mean FAT. Also, Nyjer Morgan (aka Tony Plush — AHHHHHHHHH!!!) is insane. And John Axford looks like he just stepped out of a Civil War reenactment.
Of course, nothing could be as unconventional as their storied radio broadcaster, Mr. Baseball himself, Bob Ueker. Artie Lang explains why:
If you're not havin' fun, you're not doin' it right.
Don't hate me 'cuz I'm right.


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Sept. 5, 2007
CAMBRIDGE, Mass. - After serving two seasons as a coach with national powerhouse California University, Andy Hilton has recently been tabbed to serve as the head coach of the MIT lightweight freshman crew.
Hilton served as an assistant coach with the Bears' varsity program in 2006-07, leading the varsity 4+ to Gold at the Pac-10 and IRA Championships. Hilton also served as a volunteer coach as Cal captured the National Championship in the spring of 2006.
Hilton attended Dartmouth College, receiving his B.A. in economics in 1999. He rowed for the Dartmouth lightweights and co-captained the 1998-1999 squad, sitting in the No. 3 seat in the varsity 8+ that won bronze at the 1999 IRA National Championship. Hilton also served as the lightweight intern at Harvard College from 1999-2001 before returning to the water the following season at the US Rowing training center in Princeton.
After hanging up his oar, Hilton returned to coaching part-time at Deerfield Academy where he also worked in the alumni office from 2002-2005. Andy has also spent summers coaching at Craftsbury Sculling Center in Vermont.


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The U.S. Environmental Protection Agency (EPA) and the U.S. Department of Energy (DOE) recently outlined a series of steps to further strengthen the trusted Energy Star program. In addition to third-party testing already underway, EPA and DOE have launched a new two-step process to expand testing of Energy Star-qualified products. DOE began testing of some of the most commonly used appliances, which account for more than 25% of a household's energy bill, and both agencies are now developing a system to test all products that earn the Energy Star label. The steps are part of an overall effort by the Obama Administration to improve the energy efficiency of homes and appliances to save families money.
"Energy efficiency is more important than ever to American families, " says Gina McCarthy, assistant administrator for EPA's Office of Air and Radiation. "As our economy gets back on its feet, Energy Star is an easy way for consumers to save money and help fight climate change. "
"Consumers have long trusted the Energy Star brand for products that will save them energy and save them money, " saysCathy Zoi, DOE assistant secretary for energy efficiency and renewable energy. "The steps we're taking now will further strengthen and improve the program, building on the results that consumers have come to expect. "
For more on the changes to Energy Star, read the full news release on the EPA Web site.


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What do you guys think of Hamish Marshall?
I thought his 146 In the first test vs aus was sensational.
Could be exactly what we need at no 3.
ITs strange that his first class record is so crap in nz (both 4 day and 1 day). Yet he has a superb odi record, and has made a good start to test cricket.
I think he can be our best batsman and average 45 in tests.
He is already a superb odi batsman.


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|Birth Date:
|Camarillo, Calif.
|High School:
|Rio Mesa HS
2011: Played in 26 games for the Gauchos…Scored 16 goals…Drew 13 ejections and penalties and tallied two steals…Had a season-best three-game scoring streak running from Sept. 10 through Sept. 11…Had a season-high three goals against UC San Diego (Oct. 1). Scored multiple goals on four different occasions.
2010: Redshirted.
Attended Rio Mesa High School and played for coach Derrick Timmons...Posted 344 goals, 195 steals and 95 assists for the Spartans...Was a four-year varsity starter...Awarded with First Team All-CIF honors as a junior and senior; was a Third Team honoree following his sophomore campaign...Earned three-consecutive First Team All-Pacific View League honors after being named to the Second Team as a freshman...Was the 2009 Pacific View League MVP and was twice named his team's MVP...Served as team captain during his junior and senior seasons...Led his team to the 2008 and 2009 Pacific View League Championships and the CIF Division V1 finals during the same seasons...Won the 2009 Oxnard Tournament and was named tournament MVP...Also competed in swimming for four years and helped set a school record in the 200 freestyle relay...Earned National Scholar-Athlete honors in 2010...Was the 2010 Rio Mesa High School Scholar-Athlete of the Year...Was a three-time International Baccalaureate Honors Student.
Played for Santa Barbara Water Polo Foundation...Was named to the 2009 Junior National Team, which he names as his most memorable athletic achievement...Was a member of the California Coastal Zone Team in 2007 and 2009...Won the 2009 California Coastal Zone Championship...Competed in four-straight National Junior Olympics...Led his team to the 2008 National Junior Olympics Platinum Division Finals...Was named a 2008 National Junior Olympics Platinum Division First Team All-American...Made it to the finals of the 2008 South Florida International Tournament and took third place at the United States Club Championships.
Nicholas Patrick Tomasello was born on March 24, 1992 in Camarillo, Calif....Parents are Frank and Kellie...Has three siblings: Tony, Frankie and Grace...Has yet to declare a major but would like to pursue a degree in communication...Has aspirations of one day working as a sports or talent agent...Names his dad as his personal hero...Enjoys running, playing basketball and volleyball, Frisbee, dancing and just having a good time when he is not in the pool or classroom...Favorite movie is "Indiana Jones and Raiders of the Lost Ark"...Names "Brave New World" as his favorite book...Enjoys listening to Frank Sinatra's music.


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SAN FRANCISCO, Dec. 30 (UPI) -- Michael Crabtree amassed 172 receiving yards Sunday, hauling down two touchdowns in San Francisco's division-clinching 27-13 victory over Arizona.
Crabtree made eight grabs in all and Colin Kaepernick completed 16-of-28 passes for 276 yards and the two touchdowns for the 49ers (11-4-1), who claimed the NFC West title.
Frank Gore compiled 68 yards with a score on 20 carries as San Francisco closed out the regular season with its third win in four contests.
Arizona (5-11) got a 19-of-34, 225-yard performance from Brian Hoyer in his first career NFL start behind center. He tossed a TD pass and surrendered an interception.
Michael Floyd led the Cardinals' receiving corps with eight catches for 166 yards and a touchdown.


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I don't know if this question is relevant here, or if it should wait for the upcoming Robotics Proposal, but I'll ask it anyway.
Chefs such as Heston Blumenthal and Ferran Adrià are known for appropriating various high tech pieces of equipment from labs and industry, and using them in their kitchens. I was wondering if any of them use robotic systems in the kitchen. I imagine that robotics would allow increased repeatability, reduced cost, and the ability to do things that would be very difficult for a human to do accurately or quickly, such as decorating food in novel ways.
By 'Robot' I mean something which has the ability to make controlled coordinated movements, on at least two axes, and manipulate the external world. This definition would not include things like bread makers or dishwashers, no matter how smart.


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Indiana ISTEP+ Test Prep
Overview of the Indiana Statewide Testing for Educational Progress-Plus (ISTEP+)
If you have a child in elementary, middle or high school in Indiana, then you need to know about the standardized tests your child will be taking. To comply with the federal No Child Left Behind (NCLB) Act of 2001, Indiana administers standardized tests to students beginning in 3rd grade through high school.
Time4Learning, an online education service that teaches many of the skills these exams test, offers this page to help you understand Indiana's standardized tests and how you can help your children prepare.
In Indiana, students in third through eighth grade take a standards-based test called the Indiana Statewide Testing for Educational Progress-Plus (ISTEP+). Standards-based means that test items are based on grade-specific Indiana academic content standards.
The ISTEP tests are administered to
- 3rd through 8th grade students in English language arts and math
- 4th and 6th grade students in science
- 5th and 7th grade students in social studies
End of Course (EOC) Exams
In high school, Indiana students enrolled in algebra I, algebra II, biology I, English 10, English 11 and U.S. History courses must take End of Course exams. Like the ISTEP, the End of Course exams are standards-based tests, which mean they measure specific skills defined by the state of Indiana.
Changes in Indiana's Testing Program
In the 2008-2009 school year, Indiana transitioned from administering the ISTEP+ in the fall to the spring. Going forward, the ISTEP+ will be given in the spring. In addition, the ISTEP now includes science tests in fourth and sixth grade and social studies tests in fifth and seventh grade.
Previously, the ISTEP+ administered to 10th grade students was known as the Graduation Qualifying Exam (GQE). Beginning with the 2009-2010 school year, the ISTEP+ will no longer be administered in tenth grade. Instead, the new GQE will consist of End of Course exams for Algebra I and English 10.
What do the ISTEP+ and EOC Test Scores Mean?
For the ISTEP+, students receive one of three scores for each of the subject areas tested:
- Pass+
- Pass
- Did not pass
For the EOC exams, students are scored as pass or did not pass. For the End of Course exams that make up the new GQE (Algebra I and English 10), students must pass these tests to graduate from high school.
Preparing for Indiana's ISTEP+ Test
For general tips on test preparation, please visit our standardized test overview page. The real preparation for the ISTEP+, and all standardized tests that assess a wide range of fundamental skills, is to steadily build and master skills in math, reading and writing fundamentals.
Parents can help students succeed in school by making a special effort to get involved in their children's education. You should ensure your children are doing their homework every night and reading and writing on a daily basis. In addition, families can hire tutors or use online learning programs such as Time4Learning and Time4Writing to supplement their children's schoolwork and help to build fundamental skills.
To help your children prepare for state standardized tests such as Indiana's ISTEP, you can enroll your children in a test prep program or buy books to help them become familiar with test formats and terminology, to learn test-taking strategies (when to guess, when not to), to become comfortable with time restrictions, and to practice answering different types of questions.
For instance, when a reading passage is followed by comprehension questions, many test prep programs teach students to scan the questions prior to reading the passage so that they can pay special attention to the areas addressed by questions.
Most states release copies of tests or sample test questions from previous years. Parents can use these released test questions as resources to help students practice test skills and students can spend the majority of their time reviewing the key concepts within the sample test questions.
Time4Learning is not a test prep program; instead, it is a program that builds the skills that will be tested.
Time4Learning is a new approach that takes advantage of today's technology. It's a convenient, online home education program that combines learning with fun educational teaching games.
The online language arts and math curriculum comprise a comprehensive program for preschool, elementary school, and middle school. Science and social studies programs are provided for most grades.
Kids like using the computer to learn and to develop their skills. Time4Learning's educational teaching games give students independence as they progress at their own pace.
Parents like that it tracks progress and helps kids advance by teaching through individualized learning paths that assure mastery of the skills and concepts that makes kids succeed.
Have a child with math and reading skills at different grade levels? No problem, just tell us in the online registration process.
Time4Learning is proven effective, has a low monthly price, and provides a money-back guarantee so you can be sure that it works for your family, risk free!
For more information or resources on the ISTEP+ and Indiana education, visit:
Indiana Department of Education
Indiana Homeschooling Information
Indiana State Parent Forum


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jQuery is a fast and concise JavaScript Library simplifies HTML document traversing, event handling, animating, and Ajax interactions for rapid web development. By using of jQuery you can write less but do more. There are large of ready made jQuery plugins available from generous designers and developers on the web can help add stunning functionality and effects to your website. Then you have collect 20 Perfact jQuery plungins hope them can be helpful to you. Now, let's start!
Pikachoose jQuery Image Gallery
Pikachoose is a lightweight Jquery plugin that allows easy presentation of photos with options for slideshows, navigation buttons, and auto play. Pikachoose is designed to be easily installed, easy to setup, and well… all around easy.
Easy Slider 1.5 – The Easiest jQuery Plugin For Sliding Images and Content
Easy Slider 1.5 features:
- auto slide
- continuous sliding
- "go to first" and "go to last" button
- hiding controls
- optional wrapping markup for control buttons
- vertical sliding
- multiple sliders on one page
Supersized – Full Screen Background/Slideshow jQuery Plugin
- Resizes images to fill browser while maintaining image dimension ratio
- Cycles Images/backgrounds via slideshow with transitions and preloading
- Navigation controls allow for pause/play and forward/back
The jQuery Cycle Plugin is a lightweight slideshow plugin. Its implementation is based on the InnerFade Plugin. It supports pause-on-hover, auto-stop, auto-fit, before/after callbacks, click triggers and many transition effects. It also supports, but does not require, the Metadata Plugin and the Easing Plugin.
prettyPhoto is a jQuery based lightbox clone. Not only does it support images, it also add support for videos, flash, YouTube, iFrames. It's a full blown media lightbox. It comes with useful APIs so prettyPhoto can be launched from nearly anywhere (yes, that includes Flash)!
jQuery Infinite Carousel is a scrolling carousel that works in the same way the carousel worked on the Apple Mac ads page.
Galleriffic is a jQuery plugin for rendering fast-performing photo galleries. It was inspired by Mike Alsup's Cycle plugin, but with performance in mind for delivering a high volume of photos.
Spacegallery is another image gallery.
prettyPhoto is a jQuery based lightbox clone. Not only does it support images, it also add support for videos, flash, YouTube, iFrames. It's a full blown media lightbox.
FancyBox is tool for displaying images, html content and multi-media in a Mac-style "lightbox" that floats overtop of web page.
jQuery Flash Plugin is a jQuery plugin for embedding Flash movies.
- Simple, but powerful.
- Flash Detection, Express Install and more.
- Accessible and Unobtrusive.
- Native and light-weight.
jQuery Media Plugin supports unobtrusive conversion of standard markup into rich media content. It can be used to embed virtually any media type, including Flash, Quicktime, Windows Media Player, Real Player, MP3, Silverlight, PDF and more, into a web page. The plugin converts an element (usually an
<a>) into a
<div> which holds the
embed or
iframe tags neccessary to render the media content.
Transcendent jQuery Date Range Selector + Short Cuts
It was packaged everything up into a nice download so even a novice can enjoy these fantastic improvements to the standard Date Picker.
New jQuery Weekly Calendar Plugin
The jquery-week-calendar plugin provides a simple and flexible way of including a weekly calendar in your application.
ClockPick is a jQuery timepicker plugin. You can set the options on the demo to see the effect.
tabSwitch is a tab/slider plugin for jQuery. You could make a tab box system with the least of code and still fully customizable. Currently, you could choose from 7 different effects with 2 view styles. You could also hot swap the effects around in runtime.
idTabs is a plugin for jQuery. It makes adding tabs into a website super simple. But it can also open the door to endless possiblities.
jQuery fade and slide toggle plugin
The jquery slidetoggle() is great, but one thing it was missing is some opacity fading in the sliding animation. fade and slide toggle plugin is a very small plugin, but you will still find the effect cooler than a regular sliding.
jQuery pageSlide was inspired by the UI work of Aza Raskin. This plugin allows any developer to recreate a similar interaction on their own website using a few simple lines of Javascript.
The s3Slider jQuery plugin shows how the layer appears. It can be on top or bottom, on left or right, or the layer can appear on all sides.


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EVERY Monday from 4:00pm until close we offer $4 pours of all of our Minnesota breweries & cideries. Also, from 4:00pm until midnight we offer our $3 award winning happy hour fries and our $6 happy burger. Come support your favorite local breweries and grab some delicious pub fare at an amazing price!
Back to All Events
Earlier Event: October 9PUB TRIVIA WITH TRIVIA MAFIA
Later Event: October 16CIDERS & SLIDERS! - EVERY TUESDAY!


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Your source for the Best Midwest and Omaha Jobs!Advanced Job Search
Careers in technology are among the fastest growing jobs in America. AIM offers a variety of programs to get you started or expand your knowledge.AIM Code School ›
Do you know a child who loves tech? We have a class for them. Explore all of the free opportunities and resources AIM offers.Brain Exchange ›
We're about so much more than just talent acquisition. Learn how AIM strengthens not only your business, but your staff, and the local community.Explore Memberships ›
From crafting the perfect resume to nailing your interview, we provide all of the tips and tricks you need to land your dream job.
Whether a company employs ten people or one-thousand, choosing who to hire when a new position comes open has a tremendous effect on not only the company's well-being, but also the performance and productivity ...More Community News »
Careerlink is operated by AIM, an innovative not-for-profit that grows, connects and inspires the tech talent ecosystem through career development and educational programs.


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Dan Morain
Dan Morain: Has labor leader overreached?
Robbie Hunter had to fill big shoes when he became president of the State Building and Construction Trades Council of California, and that is what he set out to do.
In his first year as leader of the 400,000-member labor organization, Hunter pushed legislation to expand prevailing wage law, the Depression-era concept that guarantees construction workers their pay.
The question: Has Hunter overreached?
Hunter, 56, is wiry and steely-eyed and has the remnants of a brogue, having emigrated from Ireland as a teenager. He made his way to California in 1980 and became an ironworker.
In his office, Hunter has a photo of himself wearing a hard hat and balancing on a steel beam high above Los Angeles, circa 1992. He was working on what would become Library Tower, the tallest building in California.
He became president of Ironworkers Local 433 in Los Angeles in 2002, a boom time. The union struggled through the crash of 2008, when unemployment ran at 60 percent. He became council president a year ago, succeeding Bob Balgenorth. Balgenorth defended prevailing wage in the 1990s when Gov. Pete Wilson tried to role it back, and presided over its expansion in 1999 when Gray Davis became governor. Hunter seeks more, far more.
Just as public employee unions fight for their pension benefits, the building trades council protects the prevailing wage. Adopted in California in 1931, the prevailing wage law is intended to prevent contractors from importing low-wage workers from outside the state.
Under the law, construction workers are guaranteed union wages on any public works projects paid for with state tax money. The prevailing wage requirement likely raises construction costs. But importantly, it helps ensure that California tax money is used to pay decent wages to California workers.
Hunter argues that the prevailing wage saves taxpayers' money because union workers are better trained and more highly skilled.
"We can do it with the least amount of workers in the least amount of time," Hunter said. "Do it once. Do it right. It will last for decades."
Dueling studies argue both sides. Whichever is right, Hunter has crossed serious forces this year, including the oil industry, the California Chamber of Commerce, the League of California Cities and the organization that represents hospitals, not to mention a competing union.
He also has placed Gov. Jerry Brown in a tough position. The governor, who fancies himself the adult in the room, must decide by this weekend whether to sign bills that would significantly alter labor law, or veto them and risk angering patrons who are fundamental to his base.
The building trades council has donated $1.4 million to Brown's campaigns since 2007, including $1.3 million to an independent campaign to help elect him in 2010. The 14 unions that make up the council – electrical workers, pipefitters, ironworkers and Teamsters among them – also are major donors to the governor.
In this legislative session, the council took an expansionist view of prevailing wages.
In Senate Bill 615 by Sen. Cathleen Galgiani, D-Modesto, private hospitals that obtain construction loans from the state would have to pay prevailing wages. Added labor costs would be significant as hospitals seek ways to finance as much as $110 billion in seismic upgrades.
In Senate Bill 7 by Senate President Pro Tem Darrell Steinberg and Sen. Anthony Cannella, R-Ceres, charter cities would be pressured into paying prevailing wages even when they use their own city tax money, and no state money, to pay for construction projects.
Senate Bill 54 by Sen. Loni Hancock, D-Berkeley, would require that oil refineries pay prevailing wages to employees. If Brown were to sign the bill, prevailing wage for the first time would be applied to private companies that don't get state funds, a recipe for litigation.
Hunter casts the refinery bill as a safety measure, in response to the massive fire at the Chevron refinery in Richmond last year. In fact, the bill emerged in the final month of the session and was approved on a party-line vote.
In the conference room of the council's sleek new I Street office, Hunter provided me with a stack of photos snapped in refinery parking lots of license plates, all of them out of state. He believes contractors bring in lower-paid workers, who take jobs at the expense of Californians, and aren't as skilled as building trades workers.
"We live in the shadow of these things," Hunter said. "The issue is safety."
Cathy Reheis-Boyd, president of Western State Petroleum Association, said the bill has nothing to do with safety. The issue is jobs and "more money."
"Why is prevailing wage even in a safety bill? It's not about safety. It is a jobs grab," Reheis-Boyd said.
Hunter points out that the average pay among members of organization is $54,000, hardly a king's ransom. A labor leader's job is to raise wages. But as he seeks to leave his mark, Hunter risks a backlash from powerful forces.


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Care Instructions
The liner products are hand washable. In order to keep the liner clean, please follow these instructions.
- To remove the excess dirt inside the liner, you can use the vacuum cleaner.
- In case there is excess lint on the liner, you can carefully use scissors or lint remover
Washing instructions:
- Please check the label that the liner is hand washable
- Start by removing the removable metal parts (metal loops, keychain´s locks, premium zip pulls)
- Soak the liner in lukewarm water and use mild detergent clean the liner.
- Rinse the liner carefully and fully to make sure there is no detergent left in the fabric.
- Let the liner dry out upside down for on a drying rack. Note that due to the nature of the fabric, the felt absorbs a lot of the water when washing. Thus, when you put the liner to dry it will leak water for some time. Placing the liner upside down will let the liner dry faster.
I am currently testing washing the liner in a washing machine with a hand wash program. So far the results have been good, and will add this later to the instructions when all the testing has ended.


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Migrant rafters rescued by 2 cruise ships
MIAMI— Two cruise ships have rescued migrant rafters off the Florida Keys.
U.S. Coast Guard Petty Officer Mark Barney said that the Disney Wonder and the Carnival Conquest both spotted "rustic vessels" in separate incidents Friday afternoon.
According to a Carnival statement, the Conquest picked up 13 Cuban nationals about 40 miles (64 kilometers) from Key West. The ship was expected to rendezvous with a Coast Guard cutter near Key West to transfer them.
A Disney statement says the Wonder picked up eight people about 45 miles (72 kilometers) from Key West, but their nationality wasn't immediately known. The company was working with the Coast Guard to determine its next steps.
Crews on both ships provided their new passengers with food, water and medical attention. No injuries or deaths were reported.
It wasn't immediately known what would be done with the migrants, but Barney said undocumented, non-U.S. citizens heading toward American waters are usually repatriated to their home countries.
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Last week I had to make a phone call that I knew was inevitable, but one I desperately wanted to avoid.
Jackie was a mutt from the shelter. Dog Snobs might call her a "mixed breed," but she was A Mutt. A bit of pointer, lab, some kind of terrier, maybe cocker spaniel, who the hell knows. No clue how old she was either, but we brought her home from the shelter in June 1998. I'd never had a dog before, and we didn't have kids yet, so she was my first pet and my first baby.
We named her Jackie after baseball hero Jackie Robinson. "Dizzy," for Cardinals pitcher/announcer Dizzy Dean, was a close second — and probably would have been a better choice, because Jackie the Mutt was a lot more cute than smart. We flunked two obedience courses because she never quite mastered the "don't pull on the leash" thing. So I just kept buying every possible kind of collar and harness and leash until I finally resigned myself to being dragged around the neighborhood by my 25-pound dog.
Jackie adored kids, laid claim to all the blankets in the house, and could hear a cheese wrapper from approximately three miles away.
She rarely barked, but possessed a remarkable ability to induce neighbors' dogs into frenzies of growling and howling by simply ignoring them. We like to think she was gloating about her fabulous humans.
She traveled a circuit around the perimeter of the backyard to avoid the angry squirrels who threw things at her from the ginormous maple tree in the middle.
Humans putting on shoes were GOOD because it meant either A Walk or A Treat, but a Human with a Suitcase was BAD. And she hated – HATED WITH A PASSION – pedicures. When I eventually gave up on trimming her Killer Claws myself, she would attempt to fling herself into traffic every time we walked up the sidewalk to the groomer and the Industrial-Strength Nail Clippers of Doom.
But, weirdly enough, Jackie never, ever — not even once — hung her head out the car window, so we still have doubts as to whether she was actually a real dog or not.
[This was going to be a paragraph about how Jackie became more than just a pet during my divorce, but I just can't go there yet.]
ANYWAY…Over the past few days, I've been listening to, and telling my kids, and telling myself, all the usual stuff like "It was the right thing to do," and "She's no longer in pain." But dammitall, my dog was DIFFERENT and all those generic platitudes JUST AREN'T GOOD ENOUGH.
So I bought a book.
My kids are too old for picture books, but no reader is EVER too old for a picture book like this. I put this on hold at Barnes & Noble after making The Call and picked it up on my way home from work. As soon as they saw the cover and title, both kids knew that it was time for The Talk About Jackie.
My 12-year-old daughter (aka Thing1), glanced through it, and then said, "I know what happens, Mom, I've seen Marley & Me," in her snotty tween-age voice before erupting into ugly tears and wiping her snotty nose on my sweater. But she clutched the book in her arms as we had The Talk, and she read it to her little brother before bed that night.
The nine-year-old little brother (Thing2), however, is A Questioner. Sweet Mother Of All That Is Holy, the QUESTIONS. And he never accepts "I. Don't. Know." as an answer — he'll just keep asking the same question again in a dozen different ways. Uff da. I clearly did not not inherit whatever brilliant skill my dad had for Making Up Shit On The Fly That Trusting Children Believe Until They Graduate From College.
I answered Thing2's eighty bajillion questions, most of which I'd answered 70 bajillion times before, as honestly as I could. The only questions that stumped me were the ones about cremation (managed to avoid direct answers on those), and of course, "But why does it have to be NOW? Why does it have to be TODAY?" Gah.
Dog Heaven prompted even more questions, and it couldn't help me answer the unanswerable questions, but this book did lead us to doing to some Canine World-Building of our own.
In Jackie's Dog Heaven, there are no suitcases or nail clippers, and the Mean Squirrels will cower in her presence. There will be garbage cans full of Happy Meal remains for her to nose through and nobody will care if she makes a mess of it all over the kitchen. Grandpa Phil will take her for walks and give her pieces of cheese whenever she wants and they will watch all the March Madness basketball games together. She will have a whole couch to herself and she will sleep on ALL THE BLANKIES and never have to sigh over humans warming their toes under her tummy.


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In my column Wednesday, I argued that this fall's congressional election campaign won't focus solely on Obamacare, even though some Republican candidates say they think that's the way to win.
But wait, I hear you ask: Doesn't the latest forecast from the Congressional Budget Office — the one that says Obamacare could prompt many people to leave the workforce — guarantee that the campaign will be all about Obamacare?
Maybe. But that could turn out to be a mistake for the GOP.
The initial headlines on the CBO report made its findings sound worse than they turned out to be. Some Republicans, seizing on the news, claimed that the CBO was forecasting the loss of 2.5 million jobs. But that wasn't true. In fact, the CBO was forecasting that the law would prompt some workers to decide to quit their jobs or work fewer hours. That's not the same thing.
Is that good news or bad news? Mostly bad — but not all bad. The biggest reduction in labor, the CBO said, will probably come from low-income workers eligible for Medicaid or Obamacare subsidies who don't want their incomes to rise so high that they will lose benefits. "The health insurance subsides that the act provides to some people will be phased out as their income rises, creating an implicit tax on additional earnings," the CBO pointed out. In other words, at some levels there's an incentive to stop working — not a good idea, as conservatives pointed out.
On the other hand, for some workers, the CBO said, Obamacare means they'll be able to retire earlier than they would have otherwise; no more "job lock" while employees wait for Medicare. Democrats argued that the upside was real too.
"This is not businesses cutting back on jobs," White House economic advisor Jason Furman argued. "This is people having new choices," including starting their own businesses or spending more time with their children, he added. (Unfortunately for the White House, the CBO didn't include those potential benefits in its report.)
Almost lost in the debate was what the CBO actually said about Obamacare's effect on jobs. The answer, amazingly, was: not much long-term impact either way. In the short term, the Affordable Care Act will increase demand for goods and services in the economy, the CBO said — in other words, a stimulus. At the same time, the law may also prompt some employers to delay hiring or reduce workers' hours. But both of those effects are short term and "mostly fade after a few years," CBO Director Douglas Elmendorf said.
In other words, if the central question is whether Obamacare is a "job killer," the CBO's answer is: No.
But that won't stop Republicans from saying it is — and, in some cases, citing the CBO as their source.
What's this all have to do with the fall congressional election campaign? Just this: It's still nine months until election day.
By November, more voters will have had experience with Obamacare, for good or ill. Many will still loathe the plan or blame President Obama for his empty promise that they could keep their plans. But others will like what they find, and they could turn into a new constituency for Democrats: voters who fear that the GOP will take away their health insurance.
That means Republicans who campaign only against Obamacare will be putting all their bets on just one issue, and it's not the issue most Americans worry about most: the economy.
Red vs. blue: The battle lines of 2014
Another misguided GOP attack on Obamacare
Bill Nye evolution debate: Time for a little 'unreality TV'
Follow Doyle McManus on Twitter @doylemcmanus and Google+


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biography, business, ecommerce, entrepreneur, investment, mobile, startup, tech startup, technology, venture capital, wearable technology
We read about the "20 under 20" and "30 under 30" regarding the great entrepreneurs in the startup community where there is massive growth and huge success in business and technology. We know them and we watch them amaze the world, one invention at a time.
These inventor/creators are disrupting the mainstream of how we do business, and the financial infrastructure of our entire economy. What about those that have gone before them? Are they still creating and disrupting the eco-infrastructure?
They are our older inventors and they are always there- creating, successful, not resting on their prior creative talents but rather are the example of what it means to be an entrepreneur. They respect those like them that make good things in this world happen one creation at a time, regardless of age. They are mentors, advisors and more importantly entrepreneurs at any age. Their minds are the window that you and I want to look through.
Innovation comes in many forms and it comes from the mind of ideas and inventions, with aging entrepreneurs being no exception to that leading edge. As I have worked with team inCync, I have come to realize how grounded and realistic an inventor/entrepreneur of 70+ years can be. Gone are the trappings of flashy, toy filled offices with beer taps on Fridays and street hockey in courtyards. They've already done all that. They still love their toys and your creative toys too, and they continue to contribute, to make the ones that fill real needs and bring fun into other's lives with every exciting day they work and formulate. They have offices that could rival any young Silicon Valley startup, with small rooms full of amazing ongoing brainstorms written on boards, computers and piles of paper. They play sports, racquetball and other things that keep their brains and body sharp, in order to work the 3am nights that they have been addicted too for most of their lives.
As my clients and friends at inCync have grown, I have watched streamlined and fast decision making in a startup with enormous potential. Time is never wasted, and a small team makes product decisions quickly and concisely. They learn, constantly there is a learning curve, because, you know, you are never too old to miss an opportunity to learn.
Founder, Bud Wilcox is an ambitious creator, having many products under his belt, including FreeWheelin, the blue tooth device that goes on any helmet. People can hear ambient noise while riding a bike and take a phone call hands free. Innovation made to protect those that want to enjoy music and be safe. Now with inCync, a product that does something similar and is very tiny and light, it clips to almost anything, runners, hikers, bikers and anyone else can go just about anywhere and utilize safe listening and hands-free calls. Bud has products made from a lifetime of seeing a simple need and filling it, but making sure it's the best quality that he can possibly find to ensure happy consumers.
Men and women like this have set aside ego for ambition, and it's a lesson smart people learn as the decades move forward.
I am watching the forefront of his creative mind with great wonder on my part. I am constantly surprised by how he gets things done, when he does things and the relentless pursuit of knowledge that he has. I also get the joy of knowing the next product that is coming and it's exciting to me. I would love to reveal it, but alas, it's under wraps. I can tell you that your phone will love it though.
When we think of ourselves as entrepreneurs we envision ourselves and others as young mellinials working fast, high on energy drinks and fretting over venture capital. Will you still be creating products at over 70+ years in your life with imagination and a strong sense of purpose to help the world and to fill needs? Hard to imagine that you will. Bud is proof that you can skip some energy drinks, although he admits to some coffee of course, as most entrepreneurs have some vice- while staying incredibly fit mentally and physically as an entrepreneur. We should take some lessons from those that have been there and done that, so that we can find ourselves in this select and talented pool of what I like to call, Generou-Preneurs. Will you make it?
What will you create at 70? What will you give to the world? Value and sustainability are more than words; they are the lifestyle of the entrepreneur.
Everything you just read about can be found here:
@inCyncAudio on Twitter
https://www.facebook.com/IncyncAudio on Facebook
FreeWheelin Blue Tooth
On Twitter @FreeWheelinBT
On Facebook: https://www.facebook.com/freewheelinaudiosystem


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Starfish can have as many as 40 arms called rays.
- Home
- About Us
- Bookings
- Programs
- Resources & Documents
- Links
- Contact us
- Admin
Starfish can have as many as 40 arms called rays.
'Deadly Science' is an innovative and flexible vocational educational training program delivered at the Nudgee Beach Environmental Education Centre to senior Indigenous students The Deadly Science program involves course delivery of Certificate II in Conservation Land Management (4 QCE points) over every Thursday of Semester 1. As part of the course students observe and record local flora
These chairs are able to accommodate students from prep to year twelve using a seat insert for younger students. Due to their design students sitting in the chair can still reach the sand and engage with the program and their fellow classmates in a very meaningful way.
Does your principal want your teachers to take students on meaningful excursions? Invite NBEEC to your next staff meeting for a 10 min overview on the programs we could deliver.


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- Product Information
Marvel by Camelot Design Studio for Camelot CottonsAdditional Information
Product Type Yardage Fabric Collection Marvel Comics Fabric Designer Camelot Design Studio Fabric Manufacturer Camelot Fabrics Theme Baby and Child - Boy, Licensed, Movies & Entertainment Fabric Type 100% Cotton Fabric Width 44/45" Image Scale 11" x 11" swatch of fabric
- Color Matcher
Find color matches for this product by clicking on a color below.
Disclaimer: Colors shown here are not guaranteed to match the above product and are intended as a guide.
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pulseblue necesitaba un nuevo diseño de logotipo y lanzó un concurso de diseño en 99designs.
Un ganador ha sido elegido entre 90 diseños de 31 diseñadores freelance.
Sip Eat Play Stay
Logo required for Travel and Leisure website, called Sip Eat Play Stay.
Our vision is that the logo will be represented by a TRAVEL SUITCASE, with stickers representing each element - Sip Eat Play Stay (see attached images). *See requirements for more details.
The website promotes the history, heritage and culture of Australia as travel experiences.
Experiences where you can sip, eat, play and stay across Australia - experiencing the Australian domestic AND international history, heritage and culture of Australia within Australia.
Example SIP the history and culture of Australia's vineyards, traditional English high tea & chinese tea houses, traditional Aussie pubs, international events, wine festivals, tasting clubs, authentic Scottish, Irish pubs & inns c. 1800s, great coffee locations... more
EAT authentic recipes at authentic restaurants - from French to Russian, traditional recipies & cooking methods, farmers markets, authentic Indian & Afghan spice stores, Europena & Middle Eastern butchers & bakeries, French.. oh la la... more
PLAY visit & experience heritage locations and history, monuments, architecture, traditional gardens & hedge mazes, horseriding through historic parklands, ghost tours, petting zoos, city & town walks through past and living history, festivals, ballooning... more
STAY in heritage homes, bed & breakfasts, guest houses, 50s style motels, manor houses, converted religions buildings, x-shearing quarters, country pub rooms, converted lighthouses, camp like a drover or go 5 star, every option is an experience ...more
The site is a travel site, so will be targeting any and all travellers who like to Sip Eat Play and Stay.
The company will be targeting the travel and leisure industry.
The company is targeting the Australian domestic traveller and the international traveller, for both business and personal travel.
For work or for fun.
Two versions of logo required – one horizontal, one vertical.
Logo will be a TRAVEL SUITCASE, with each word Sip – Eat – Play – Stay represented as a travel sticker on the front/side of a suitcase. Possibly an old style suitcase with straps - traditional, or a more modern suitcase(see attached images).
The logo should communicate the idea of "pack your bag and go sip eat play stay"
Each element will be respresented by an icon. Below are some ideas for how these will be represented:
Sip - (to drink slowly) might be a wine glass
Eat - might be a knife and fork / plate
Play - might be a figure of a human in activity / sun / something fun.
Stay - might be a house icon / bed
I like the idea of incorporating images like tourist signs you see on the freeway as the look and feel of the four images
The logo will obviously appear on the website.
The website will have a web 2.0 look-and-feel. There will be plenty of user interaction. The site will have a clean, polished look
Colour Scheme
The colours for the logo will be lively but integrated. Not too crazy, but just exciting enough to give the viewer a warm, comfortable and welcoming feeling.
As this site promotes AUSTRALIA, I would like to use the colours of Australia - red of the outback, blue sky/ocean, yellow/orange of the sun, green of the rolling hills etc etc. I want strong colours, not washed out.
Descubre cómo funciona un concurso de diseño u obtén más información sobre nuestros servicios de diseño de logo.


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English Teacher
In the book The English Verb: An Eploration of Structure and Meaning by Michael Lewis I found this:
My question is whether the 'so-called' declarative verbs are the same thing as performative verbs.1) I pronounce you husband and wife.
This usage is restricted to certain verbs - I shall call them declarative verbs - in which the saying of the sentence is the action described by the sentence. Further examples are:
I swear by almighty God... (the oath taken in court)
That's all right, I forgive you.
Thank you in advance
Those examples are to me.


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I'm lost on this example problem. My professor did not explain it very well and the book is no help either. Any help would be appreciated. Here goes:
For each of the following cases, you are given a set of prepositional logic statements that is true. Using resolution, determine which of the individual statement is true or not.
Example (A OR NOT B), (A OR NOT C), (C OR D), (A OR NOT D) – by resolution, you can show that A must be true (but nothing about B, C, D individually)
a. (A OR B OR C), (NOT A OR NOT B), (NOT C OR NOT D)
b. (NOT A OR B), (C OR NOT D), (NOT C OR NOT D), (A OR B OR D)


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Do you need a winch? Of course you do, everyone does.
Thankfully, Pat Goss is here to help educate us, the buying public, on the importance of winches. That's why Pat turns to Scott Peterson, the Senior Design Engineer for Superwinch, not the convicted murderer.
In a segment that is definitely not an ad for Superwinch, Peterson recommends capacity be your first area to check when looking for a winch, and then shows off a Superwinch product.
Ok, enough of me. Learn how to winch, or should I say, superwinch your way out of any situation. Wait, what's that? I should just say winch and not superwinch? Ok. You got it!
MotorWeek Theater is our showcase of some of our favorite classic reviews from public television's finest motoring program. How does this video only have 1,337 views on YouTube? Winching must be learned!


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Our 12 m bin is our largest bin very popular for house clean outs with years of rubbish mounted up. Building sites and home renovations along with section clean ups The 12m bin has opening doors at the back for user friendly loading.
12m cubic rubbish bin
Dimensions Width: 1.900m Length: 3.300m Height: 1.800m


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LeTourneau University team of computer science majors competed in the University of Chicago's 2013 Invitational Programming Contest this past weekend.
Even up against stiff competition from universities like Stanford, MIT, and Columbia, the LETU team still managed to earn themselves an honorable mention.
The contest was open only to teams who already qualified for the 2013 ICPC world finals, which the LETU team qualified for last year when they took first place in the 2012 South Central USA Regional ICPC.
Since the ICPC doesn't distinguish between universities with undergraduate and graduate programs, the LETU team of only undergraduates faced the extra challenge of taking on teams which included graduate student members.
"LETU is the only undergraduate school in our region that has sent teams to the World Finals since 1993, when a team from Abilene Christian University was invited," said LETU computer science professor Dr. Brent Baas, the team's faculty sponsor.
The team members won't be resting anytime soon, though, because they are already planning for their next competition: the ICPC World Finals from June 30 - July 4 in St. Petersburg, Russia.
Categories: (none)


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Metals/Coil Processing
Norfolk Iron and Metal Commissions New CTL Line
There are 0 comments | Post a comment
Friday, October 1, 2010
Steel-service center Norfolk Iron and Metal has commissioned a new temper mill cut-to-length line at its facility in Norfolk, NE. The line, designed and built by DBI Manufacturing, Irving, TX, processes coils to 96 in. wide of steel to 0.787 in. thick and to 100-KSI yield strength. It includes a four-high temper mill, two levelers, a six-roll brush cleaning system and a rotary shear. Norfolk Iron and Metal operates five plants to serve steel users in 15 states.
DBI Manufacturing: 972/438-7150; www.dbimfg.com
See also: Delta Steel Technologies
Related Enterprise Zones: Coil Handling
Reader Comments
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New study on "The Personal Cloud: A Strategic Imperative for Operators - Competitive Market Trends, Forecasts and Operator Business Models"
Albany, NY -- (SBWIRE) -- 01/10/2018 -- The 'Personal Cloud: A Strategic Imperative for Operators' report by Pyramid Research provides an overview of operators and cloud computing, an analysis of the personal cloud market, the results of an operator online survey about their views on personal cloud and a detailed assessment of how operators are positioning their personal cloud services.
Key Findings
The number of global personal cloud accounts has increased 60% over the past two years, and Pyramid Research expects it to grow a CAGR of 25% from 2013 to 2018.
Apple, Dropbox, Google and Microsoft dominate the market, together having over 85% of personal cloud accounts.
By the end of 2014, over half of all operators around the world will have launched a personal cloud service.
Personal cloud services offer many benefits and opportunities for operators that are well positioned to differentiate their services.
Request for report sample copy : https://www.marketresearchreports.biz/sample/sample/194706
This report offers detailed analysis of the global personal cloud market, with market size forecasts covering the next five years. The report also provides an overview of the current status of the personal cloud market and how operators are positioning themselves within it.
In particular, it provides:
An overview of cloud computing with respect to network operators and the different ways in which they can benefit from it
Market size, growth and market shares by number of accounts, as well as a revenue forecast.
An analysis of the positioning of the major players, of the various business models and of conversion rates.
An analysis of why we believe the personal cloud opportunity is strategically important for network operators.
An analysis of the evolution and development of personal cloud services.
An analysis of the different business models available to operators including churn reduction, premium services, advertising and content distribution.
An in-depth case study of KDDI.
An analysis of the different ways in which operators can differentiate their personal cloud services, in particular integrating with other services and growth opportunities.
The results of an online survey of network operators about their views on personal cloud.
Request for report TOC here: https://www.marketresearchreports.biz/reports/194706/the-personal-cloud-a-strategic-market-research-reports/toc
Reasons To Buy
This report will highlight to the reader the importance of the personal cloud market, and why we believe operators need to look at the opportunity as a strategic imperative.
This report provides the reader with an understanding of how cloud computing impacts operators after which it provides a deep understanding of the personal cloud market.
The reader will gain an understanding of the competitive landscape, how the major players position themselves compared to the operators.
The analysts have placed a significant emphasis on the business models available to operators, providing examples from around the world which demonstrate different approaches and ways to position these services.
The analysts have furthermore placed a lot of emphasis on showing how operators can differentiate their services and why they are uniquely positioned to make the most of this opportunity. This includes looking at three related services which can be integrated with personal clouds which further highlight their strategic importance and the potential for increasing loyalty in high value segments.
Section 4 provides the results of an online survey of network operators' views and expectations of personal cloud services from around the world.


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The amount of how to convert inches to cm
So, how to convert inches to cm! 1cm = 0.39370079 inches. As there is 2.54 cm in an inch, to convert your cm figure to inches you need to split your figure by 2.54. Must you want to transform from inches to centimeters, give the inches to cm converter a try.
How to know how to convert inches to cm
Know the difference between a centimeter and an inch, how to convert inches to cm. The centimeter (centimeters.) steps length and distance. It belongs to the statistics system, which is utilized worldwide. It is one-hundredth of a meter. An inch is a system of measurement that measures size and range. It is, how to convert inches to cm, generally only used in the United States, Canada, and the United Kingdom. It is abbreviated as (in.) It is 1/12 of a foot and 1/36 of a yard. [1] 1 cm. equals 0.394 inches.
It is easy to know, how to convert inches to cm, look at Right Sidebar, there is Length Converter for You!


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Type: One-shot
Volumes: Unknown
Chapters: 1
Status: Finished
Published: Not available
Genres: Hentai
Authors: Yamamoto, Kenji (Story & Art)
Serialization: None
Score: 5.131 (scored by 93 users)
1 indicates a weighted score. Please note that 'Not yet published' titles are excluded.
Ranked: N/A2
2 based on the top manga page. Please note that 'R18+' titles are excluded.
Popularity: #22059
Members: 170
Favorites: 0


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[18F]Fluciclatide-PET, Pazopanib and Paclitaxel in Ovarian Cancer (PAZPET-1)
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT01608009
Recruitment Status : Completed
First Posted : May 30, 2012
Last Update Posted : March 10, 2017
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
|Condition or disease
|Ovarian Neoplasm
|Drug: Pazopanib and paclitaxel
|Phase 1
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|16 participants
|Intervention Model:
|Single Group Assignment
|None (Open Label)
|Primary Purpose:
|Official Title:
|Phase 1b Exploratory Study of [18F]Fluciclatide-PET as a Marker of Angiogenic Response to Combination Therapy With the Pan-VEGF Inhibitor, Pazopanib, and Weekly Paclitaxel in Platinum Resistant Ovarian Cancer
|Study Start Date :
|July 2012
|Actual Primary Completion Date :
|May 2015
|Actual Study Completion Date :
|April 2016
|Experimental: Pazopanib and paclitaxel
Drug: Pazopanib and paclitaxel
Pazopanib 800mg od for 7 days, followed by 18 weeks of combination therapy (paclitaxel 80mg/m2 weekly and pazopanib 800mg od). Following the completion of combination therapy, patients will continue on maintenance pazopanib 800mg od until disease progression.
- Assessment of change in [18F]-fluciclatide retention parameters following 1 week of pazopanib treatment [ Time Frame: 1 week ]Semi-quantitative standardized uptake value and fully quantitative net irreversible plasma to tumour transfer constant
- The proportion of women who experience side effects from the combination of paclitaxel and pazopanib [ Time Frame: 12 months ]Core study assessments including physical examination, vital signs, ECG, and adverse event reporting
- The proportion of patients responding to combination paclitaxel and pazopanib [ Time Frame: 12 months ]
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years and older (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Age ≥ 18 years
- Diagnosis of relapsed ovarian cancer
- Responded to at least on one line of prior platinum based therapy
- Relapsed within platinum resistant interval (≤6months)
- Eastern Cooperative Oncology Group (ECOG) performance status of <2
- Measurable disease defined as a lesion that can be accurately measured in at least one dimension with the longest diameter ≥25mm using conventional techniques
Satisfactory baseline haematologic and organ function:
- Haematologic: Absolute neutrophil count > or = 1.5 X 10^9/L; Platelets > or = 100 X 10^9/L; Haemoglobin > or = 9g/dL; PT or INR < or = 1.2 x ULN; PTT < or = 1.2 x ULN
- Hepatic: Bilirubin < or = 1.5 X ULN; AST or ALT < or = 2.5 X ULN
- Renal: Serum creatinine < or = 1.5 mg/dL; Or if >1.5 mg/dL, calculated creatinine clearance > or = 50mL/min; UPC <1
Exclusion Criteria:
- Poorly controlled hypertension [defined as systolic blood pressure (SBP) of ≥140 mmHg or diastolic blood pressure (DBP) of ≥ 90mmHg]. Note: Initiation or adjustment of antihypertensive medication(s) is permitted prior to study entry. BP must be re-assessed on two occasions that are separated by a minimum of 1 hour; on each of these occasions, the mean (of 3 readings) SBP / DBP values from each BP assessment must be <140/90 mmHg in order for a subject to be eligible for the study.
Treatment with any of the following anti-cancer therapies:
- radiation therapy 28 days prior to the first dose of pazopanib OR
- surgery or tumor embolization within 14 days prior to the first dose of pazopanib OR
- chemotherapy, immunotherapy, biologic therapy, investigational therapy or hormonal therapy within 14 days or five half-lives of a drug (whichever is longer) prior to the first dose of pazopanib
- Treatment with anti-angiogenic therapy
- Presence of gross ascites
- Clinically significant peripheral neuropathy
- Females of childbearing potential who are unwilling to avoid pregnancy, for the duration of the study
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01608009
|United Kingdom
|Imperial College Healthcare NHS Trust
|London, United Kingdom
|Southend University Hospital NHS Foundation Trust
|Southend, United Kingdom
|Study Director:
|Rohini Sharma, MD
|Imperial College London
|Principal Investigator:
|Timothy Crook, MD
|Southend University Hospital NHS Foundation Trust
|Responsible Party:
|Imperial College London
|ClinicalTrials.gov Identifier:
|NCT01608009 History of Changes
|Other Study ID Numbers:
|First Posted:
|May 30, 2012 Key Record Dates
|Last Update Posted:
|March 10, 2017
|Last Verified:
|March 2017
platinum resistant
ovarian cancer
Ovarian Neoplasms
Carcinoma, Ovarian Epithelial
Endocrine Gland Neoplasms
Neoplasms by Site
Ovarian Diseases
Adnexal Diseases
Genital Diseases, Female
Genital Neoplasms, Female
Urogenital Neoplasms
Endocrine System Diseases
Gonadal Disorders
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Albumin-Bound Paclitaxel
Antineoplastic Agents, Phytogenic
Antineoplastic Agents
Tubulin Modulators
Antimitotic Agents
Mitosis Modulators
Molecular Mechanisms of Pharmacological Action