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One of the big questions from last season on the show Lost was "what lies in the shadow of the statue?" To which Richard Alpert replied, "Ille qui nos omnis servabit" ("He who will save/protect us all"). Latin's the secret language of the Others, and being able to answer that question demonstrates a knowing fidelity to Jacob, the island's god-like seeming protector/ruler/primary servant. Those with the answer have been (it seems) in personal contact with Jacob, rather than merely receiving his orders through some tertiary representative. Complicating the exegesis here was the appearance last season of another figure in the statue's shadow, Jacob's nemesis (as yet unnamed, but many have suggested Esau for good reason -- which is only reinforced in Season 6's premiere when he, in the form of Locke, states his rasion d'etre is to go home, or, one might say, reclaim his birthright -- "home" would appear to be the Temple, where he once resided as the smoke monster, but is now kept out using that protective ash). At the beginning of Season 5's finale, while watching the arrival of the Blackrock (an old pirate ship), there was a God versus Satan sort of dialog between Jacob and his nemesis, expressing their respective positions towards man (qua island visitors):
Nemesis: They come, they fight, they destroy, they corrupt. It always ends the same.
Jacob: It only ends once. Anything that happens before that ... is just progress.
A straightforward reading would be the tried and true and utterly boring good versus evil, but Lost never does anything straightforwardly, so I ain't buying it. First, notice the pun on 'lies' in the question: both Jacob and the Nemesis are shown existing by the statue, but, like that old riddle of the doors (cf. Labyrinth), we viewers don't know which one might be lying, leading to damnation, or telling the truth, leading to salvation (or if they're both liars). The Nemesis has certainly been a deceiver, but it might prove in the service of truth (e.g., the classic case of hiding Jews from Nazis). The clearest case of his deception is in taking the form of Ben Linus' dead daughter, Alex, in order to get Ben (who's a master of deception in his own right) to follow the Nemesis' other avatar, Locke, in his plan to kill Jacob (and thereby giving the reason why Ben wasn't supposed to return to the island after leaving it at the end of Season 3). Which brings up the second problem: who's plan necessitated the death of Locke and the return of the Oceanic 6 to the island?
The apparition of Jack's father, Christian, informed Locke that he'd have to die (as a "sacrifice") in order to bring the 6 back (there was a time loop involving Richard Alpert, but basically it was Christian). Now, it's questionable whom this apparition is serving, but it seems clear enough in Season 5's finale that Jacob was the one taking an interest in having the 6 come together on the island in the first place (he's shown visiting each of them at a point in their lives). Furthermore, he gives Hurley a guitar case whose content -- a big ankh with a message inside -- plays a crucial role in Season 6's premiere, namely in getting his Temple followers to repair Sayid (who's shown dying and then resurrected at the end of the episode). Thus, the loophole that the Nemesis needed to kill Jacob came about through the latter's own machinations, namely the former begins to use Locke's form only after he's died due to Jacob's devising. Being fully aware of the rules of the game he's playing, it is to counter the Nemesis' likely (preordained?) move (i.e., the taking of Locke's form) that Jacob requires the real Locke's body to be returned to the island (as material counterevidence to this guy who looks and sounds like Locke). My point is that both of these island entities practice deception to get their "game pieces" into place (Jacob, for example, withholds foreknowledge of Sayid's death to get Jack and his team to the temple), and we viewers have no reason for suspecting one is more benevolent than the other. So what about Sayid?
It would seem that the resurrected Sayid is being set up as a new body for Jacob to go against "UnLocke," pointing to some simplistic Manichaean battle on the horizon. And, sure, we see Sayid in a variety of crucified Christ poses leading to his being baptized in the Temple's fountain. But the Last Supper promo poster (shown at the top of this post) suggests a third ambiguity. UnLocke is in the position of Jesus, Sayid as Judas. And, as I discussed previously, Lost has so undermined the use of faith as a crutch (cf. the Nemesis' take on Locke's dying thought: "'I don't understand.' -- Isn't that just the saddest thing you ever heard?") that even if the narrative comes down to two opposing forces, the decision to side with one over the other will in and of itself be unlikely rewarded with some Divine assurance, gratitude or redemption. Note the common element of determinism in both of the theistic players' interpretation of their game: Jacob's version is that of teleological progress to one point, a straight line being drawn through possible worlds. The Nemesis' view is that of the eternal return, the same players and events going round and round. (The alternate universe that's now been set up could support either view.) Locke's faith reduced him to a point on the line, or cog in the wheel. As UnLocke suggests of his source material, there's something admirable about Locke's fidelity to this newfound order and his rejection of the "pitiful life he left behind," but, then again, Jack's assertion of his own agency, his existential resistance to the deterministic order by attempting to nuke it out of existence, has left him alive.


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What's New
iPhone 5 support.
iPad support.
Minor bug fixed.
App Description
free for very limited time.
Don't miss this chance.
Have you made up your mind to get tattoo? Then, first thing you need to do is downloading Tattoo Mania.
This amazing app, Tattoo Mania, helps you find the ideas and inspiration you need when getting a tattoo.
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This is the App you will ever need! Even those who don't want any tattoo will go get a tattoo.
App Changes
- June 08, 2014 Initial release

subset: commoncrawl


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Miami encouraged by work done at GM Meetings
ORLANDO, Fla. -- No deals are imminent for the Marlins, but several potential matchups are taking shape as the General Managers Meetings wind down.
"I will leave here encouraged," president of baseball operations Michael Hill said.
ORLANDO, Fla. -- No deals are imminent for the Marlins, but several potential matchups are taking shape as the General Managers Meetings wind down.
"I will leave here encouraged," president of baseball operations Michael Hill said.
The GM Meetings wrap up on Thursday, and in the first few days, team officials have had a number of conversations with teams willing to make deals. Upgrading the offense is the primary focus. To do so, Miami primarily is looking at trade options over free-agent signings. The club's position of strength is pitching.
Despite finishing 62-100, the 2013 squad remarkably boasts the best team ERA in franchise history. The Marlins' starters and relievers combined for a 3.71 ERA, which topped the 3.83 mark posted by the 1997 team that won the World Series.
"When you have starting pitching that you're willing to part with, you should be able to make some deals," Hill said.
The question is whether the team will part with anyone from its big league rotation. Jose Fernandez, who won the National League Rookie of the Year Award on Monday, is, of course, untouchable. But what about Nathan Eovaldi or Henderson Alvarez? Would Miami part with its projected Nos. 2 or 3 starters to improve the offense?
Ideally, the Marlins do not want to subtract from their big league roster.
Jacob Turner and Tom Koehler rounded out the rotation at the end of the season.
Left-hander Andrew Heaney, the ninth overall pick in the 2012 First-Year Player Draft, has been excelling in the Arizona Fall League, and he will get an opportunity to battle for a rotation spot in Spring Training. Perhaps he will be better off starting out either at Double-A Jacksonville or Triple-A New Orleans.
Still, the Marlins showed they will promote a talented arm quickly when they brought up Fernandez at age 20 -- two years removed from being drafted 14th overall in 2011.
"We want talent. We've done our prospect deals," Hill said. "We're trying to get better and acquire players who help us now and into the future."
In the Minors, the Marlins have some attractive pieces to dangle in trade discussions, like Justin Nicolino, Anthony DeSclafani, Adam Conley, Brian Flynn and Brad Hand.
To part with any of their top pitching prospects, the Marlins will be seeking offensive players who can step in and contribute in 2014.
"That's the only scenario that makes sense. In our situation, it's to get something back," Hill said. "Obviously, our close-to-Major League-ready starting pitching and our young Major League starting pitching is attractive.
"There has been in interest in that, for good reason. It's the toughest commodity to acquire. It has to be something that is not, in our eyes, a short-term fix for us to part with."
The Marlins also would consider trading prospects for prospects.
Miami's front office is trying to figure out what makes sense and how to maximize a payroll that may wind up around $45 million.
The Marlins aren't anticipating many changes in the bullpen. Closer Steve Cishek will be heading to arbitration for the first time, but he isn't considered a trade piece.
The team has had discussions about bringing back veteran Chad Qualls, who is a free agent. If Qualls doesn't return, a possible veteran replacement could be someone like Frank Francisco, the 34-year-old free agent who spent the past two seasons with the Mets.
Miami is in the market for a catcher to split time with Jeff Mathis, and the club is seeking a third baseman. A potential fit at catcher is Chris Iannetta of the Angels, who is available as a trade option. The Marlins also are having internal discussions about Cuban catcher Yenier Bello, a 28-year-old free agent.
At third base, Juan Uribe is a free agent who has been mentioned as a possible fit. For the Marlins to land Uribe, a couple of things have to fall into place. First, the veteran would have to agree to go from a contender like the Dodgers to a team that is rebuilding. Second, he may be seeking a two-year deal, and his cost could be higher than Miami has budgeted. David Freese of the Cardinals could be a trade possibility, but at this point, that appears to be a long shot.
In the outfield, the Marlins are hopeful Marcell Ozuna shows his left thumb has recovered and he is ready to become the everyday center fielder. Ozuna suffered his injury in late July, and he recently began playing winter ball in the Dominican Republic.
"He made such tremendous improvement and strides in his plate discipline and his offensive approach at the Major League level," Hill said. "His approach, truthfully, at the Major League level was better than it was at the Minor League level. You didn't see the power numbers, but you saw more average and more consistent contact.
"I'm very much looking forward to him coming in and winning a job in Spring Training."
If Ozuna wins the starting job, it likely would be in center field, where he would be flanked by Christian Yelich in left and Giancarlo Stanton in right.
Jake Marisnick may start off at New Orleans as he seeks to improve offensively.
"[Marisnick] can play defensively, but we need offensive consistency and better strike-zone awareness," Hill said.
Joe Frisaro is a reporter for MLB.com. He writes a blog, called The Fish Pond. Follow him on Twitter @JoeFrisaro.


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Amoeba Music and Phil Blankenship are proud to present some of our film favorites at Los Angeles' last full-time revival movie theater. See movies the way they're meant to be seen - on the big screen and with an audience!
Saturday May 24
Jack Elam in
Creature From
Black Lake
1976, 91 min.
New Beverly Cinema
7165 W Beverly Blvd
Los Angeles, CA 90036
(323) 938-4038
Midnight, $7
May - New Beverly's 30th Anniversary!
May 24 Creature From Black Lake
May 31 Zardoz
June 7 Heavenly Bodies
June 21 John Carpenter's Prince of Darkness
June 28 Van Damme in Sudden Death
July 5 Delta Force
July 19 Just One Of The Guys
July 26 Aliens
August 9 Rainbow Brite & The Star Stealer


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Holiday Inn & Suites Chicago O'Hare - Rosemont
Holiday Inn & Suites Chicago O'Hare - Rosemont
10233 West Higgins Road
10233 West Higgins Road
Rosemont, Illinois
United States
Check In: 3PM
Check Out: 12PM
Check-in Age: 21
Book With Us Advantage
- Best Price Guarantee
We promise you access to the guaranteed best available prices, or your first night is free.
- Online Reservation Guarantee
Your room is guaranteed.
- No Booking Fees!
We do not charge any booking fees for making reservations directly with us.
- Data Privacy and Site Security
IHG takes your privacy seriously and works to protect you. All personal information you provide is encrypted and secure.
Welcome to Holiday Inn & Suites Chicago O'Hare - Rosemont
Relax at the Holiday Inn and Suites Chicago O'Hare- Rosemont
The Holiday Inn and Suites hotel, located in Rosemont, IL is minutes to O'Hare International Airport (ORD). This Chicago airport hotel is also near Allstate Arena, Rivers Casino, Donald E. Stephens Convention Center & The Fashion Outlets of Chicago and the Rosemont Entertainment District.
The Holiday Inn & Suites Chicago O"Hare - Rosemont delivers an array of services, including free shuttle service to and from O'Hare International Airport (ORD), complimentary 24-hour Business Center and Fitness Center. All guest rooms feature mini-fridge, microwave, coffee maker and work desk with free Wi-Fi. Try the famous Harry Caray's Italian Steakhouse restaurant, conveniently located off the main lobby for breakfast, lunch or dinner. The Holiday Inn and Suites Chicago O'Hare-Rosemont has over 3,000 sq. ft. of flexible meeting space and staff to cater your next corporate or social event.
Kids Stay and Eat Free
Kids ages 18 and under stay for free when sharing their parents' room. Up to four kids ages 11 and under eat free any time of the day in any Holiday Inn® on-site restaurant.
|Kids Stay Free
|Kids Eat Free
|United States, Canada, Central America, South America, Mexico, Caribbean
|18 and Under
|11 and Under
Free High-Speed Internet
Standard Wireless Internet service is included for all guests.
Shuttle/ Parking
- Car Parking Available
- Self-Parking Fee: 18 USD
- Parking is $18 per day. We offer a parking discount of $180 for 10 days. It will be a $12 additional fee per day for every day after. Guest redeeming Reward Nights, can add the supplement upon check in. 24 cancelation.
Pet Policy
- Pets allowed
- Service Animals Allowed
- Pet Fee per Night: 150 USD
- 150.00 per day non refundable. Any damage caused by pet to the room is 250.00 non refundable.
Languages Spoken by Staff
Credit Cards
- American Express
- Visa
- MasterCard
- Diners Club
- Carte Blanche
- Discover
- Smoke-Free Facility
- Number of Floors: 11
- Total Number of Rooms: 300
- Number of Suites: 70
- Number of Non-Smoking Rooms: 300
- Number of Accessible Rooms: 20
- Public Spaces Renovated in: 2016
- Guest Rooms Renovated in: 2016
- Public Entrance
- Guest Rooms
- Elevators
- Public Restrooms
- Registration Desk
- Exercise Facility
- Business Center
- Number of Accessible Meeting Rooms: 4
Accessible Hotel Areas
- Registration Area
- Accessible Guest Rooms
- Business Center
- Meeting Room
- Exercise Facility
Hotel Areas with Accessible Routes from Accessible Public Entrance
- Accessible Self-Parking
- Van Accessible Self Parking
- Ramp Access
- Portable Bathtub Seats
- Closed Caption TVs
- Telephone with TDD
- Visual Alarm/Alert in Guest Rooms
- Visual Alarm/Alert in Public Spaces
- Communication Kits with Visual Alarms
Provided by Hotel


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The Next Big Thing? Homage Trailers/
Yesterday, I posted how Edward Burns has found inspiration in the classics, or at least in the classics' trailers. I get a huge kick from his "remakes" that he has created around his new film NICE GUY JOHNNY. "Homages" to the greats are both funny to watch and a great discovery tool. So if you had a jones for more after yesterday's serving of Antonioni's L'AVVENTURA, why stop there? Here's Eddie's remake of Godard's CONTEMPT:
And of course, the original:
NICE GUY JOHNNY opens everywhere on all platforms October 26th.


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The affects of the drought continue. The cow count must come down and the tough decisions on which cows to sell or keep must be made right now.
In a productive herd, it is painful to look at the cows visually or on records and realize some must move to a new home. This year's fall culling at the Dickinson Research Extension Center needs to be a little deeper.
Feed and transportation costs limit the number of cows we can keep for the winter. Those that are structurally unsound quickly follow the open cows. Then it is the cows with udder problems and the "snorters" (cows with attitude).
The next step is to get the list of cows and sort. The timing is good because the chapter up for discussion in the animal genetics and applied animal breeding class that I teach at Dickinson State University is quantitative genetics.
One of the first principles brought up is that all animals are a product of their genotype (their genes, and environment). The relationship between genotype and the environment is important to understand. When reducing breeding cow numbers, the inherent genetics within a herd cannot be brought back easily. However, the production attributed to management can be.
This is important because a particular producer's management skills can be applied to all cattle in the large picture of cattle production. If one were managing average cattle in times of increased costs, it would seem logical to let the cattle go down the road and repurchase cattle when the time is right.
The management should not change and the expected performance of the average cattle that one buys back should reflect the management skills of the producer. In many circles, this is called commodity production and is a major component of the cattle market.
Many good producing cows go to sale every year and simply need a good manager to keep them in production. However, as times continue to change and the demand for age, source or managerial verification grows, the concept of individual animal inventories also receives more discussion and more producers acquire the tools needed to orientate or focus their production.
Ultimately, genetics that are more refined are present in the herd. If one has invested a lot of time and effort into a particular genotype and spent capital on purchased genetics, more care needs to be taken to assure that the core genetics is maintained within the reduced herd.
When culling, the first thing a producer needs is a list of all the cows in the herd. If the cattle are not available by individual identification numbers along with appropriate pedigree and performance information, there is very little one can do except sort by the eye and hope there is a strong correlation between what one sees and the genetics under the hide.
Stacking similar bull pedigrees will help, especially if a producer has focused objectives and is very selective and thoughtful about what bulls the cows are exposed to. Cows are half the genetics of their sire and, on average, one-fourth of the maternal grand sire. In other words, the cow is her mother's sire and one-eighth of her maternal grandmother's sire.
If one adds up those percentages, what becomes obvious, even in a genetics class, is that the majority of the genotype of the herd is greatly influenced by the last three sires utilized in the herd. Yet, a list of cows with corresponding production history is an invaluable and much appreciated tool when the herd needs to be reduced.
Ultimately, the cow list is sorted quickly. The lower producing cows and those that may not meet the current program objectives are added to the sell list.
The net result is fewer cows, less feed. May you find all your ear tags.


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Steve Austin book
64 Pages
Pro Wrestling Legends presents: The Story of the Wrestler They Call "Stone Cold."
When "Stone Cold" Steve Austin won his first WWF World Title at Wrestlemania XIV, he realized his greatest dream. But, Vince McMahon owner of the WWF, wasn't so pleased by this shocking victory over Shawn Micheals."Stone Cold" did not fit McMahon's profile of the 'perfect' World Champion.
The truth is Austin has always broken the conventional mode. Some fans may not remember in the early 1990's when he and Brian Pillman enraged fans as the arrogant "Hollywood Blondes" who eventually would become WCW Tag Team Champs. Eventually Austin would grow fed up with his mistreatment and go to the WWF, where he would sky rocket in popularity, bringing the entire wrestling industry along.
From the spotlight of the ring, to the cover of TV Guide Magazine Austin has become one of the most recognized wrestling stars of all time.
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Tests suggest A320NEO engines will deliver on promises, but who will win in the long term?
Engine manufacturers constantly trade claims over whose product performs best, traditionally comparing apples to apples, turbofan to turbofan. But as the battle to power the Airbus A320NEO intensifies, engine makers increasingly are exchanging fire over their technology choices. Pratt & Whitney's success in winning five applications for its geared turbofan (GTF)—and defeating conventional turbofan offerings on four of them—has changed the tone of the engine war of words. No more apples to apples, it's now architecture against architecture.
General Electric and Snecma, its partner in the CFM International joint venture, have placed their bets on carbon-fiber and ceramic-matrix composites and other advanced technologies enabling conventional turbofans to continue providing the fuel-burn improvements airlines need. Pratt has put its money on introducing a gearbox to provide a step change in fuel burn and enable the engine to run cooler, with fewer parts and more conservative technology. Now, with one engine certificated and two more on test, Pratt is looking to the future, and its plans could pose a challenge to the other manufacturers.
The skirmishes have implications beyond the horizon of narrowbodies now in development, principally the A320NEO and Boeing 737 MAX, as technology decisions taken a decade ago and now reaching fruition look set to shape commercial engine development for the decade to come. Firmly established in the 15,000-33,000-lb.-thrust range for single-aisle aircraft, Pratt is now eyeing the 70,000-100,000-lb.-thrust requirements for the twin-aisle market dominated by GE and Rolls-Royce.
At the same time, airframers and airlines are demanding ever greater reliability at entry into service, forcing engine manufacturers to select technologies earlier and spend more time and money maturing them even before beginning development of a specific powerplant. The bets each company placed on architectures and technologies a decade or more ago are at the core of today's hype and counter-hype.
CFM International kicked off the latest fracas at the Paris air show, claiming its Leap-1A engine has up to 3% lower specific fuel consumption (sfc) than the rival PW1100G geared turbofan on the A320NEO. "The Leap will go into revenue service on the A320NEO 1% better than the competition, based on testing to date," says Chaker Chahrour, CFM executive vice president. "It will retain that 1% better than the competition, which when you integrate over time adds up to another 1%. And on the A321NEO, because of the longer legs and our better cruise sfc bucket, we get another 1%."
CFM's claims are based on results from the latest tests of key advanced technologies in the Leap-1, including 3-D woven composite fan blades, compressor variable bleed valves, and an uncooled ceramic matrix composite (CMC) turbine shroud. Just-completed tests of the third eCore demonstrator—comprising the high-pressure compressor, combustor and high-pressure turbine of the Leap-1—showed "better component efficiencies than expected," Chahrour says.
Pratt was quick to dismiss CFM's claims, but was stung into defending the technology in its engine and detailing its plans to introduce new advances over time to continue driving down fuel burn. At Paris, President David Hess restated that there is no way CFM can achieve the advantages in fuel burn and maintenance cost it is claiming "unless they defy the laws of physics." Pointing out the Leap-1A will not run until this fall, he says "our NEO engine is flying and, in the most recent configuration, the fuel-burn numbers are half a percent better than prediction."
Both CFM and Pratt aim to reduce fuel burn by at least 15% from the engines now powering the A320. CFM says 50% of the Leap-1A's fuel savings come from improved propulsive efficiency, with increased fan size and bypass ratio, and 50% from improved thermal efficiency, including higher temperatures. Pratt says only 4-5% of the PW1100G's fuel savings come from the gearbox, which enables a larger, slower-turning fan to be driven by a faster, more efficient low-pressure (LP) turbine. "The other 10-11% is from the rest of the engine," says Bob Saia, vice president next-generation engine family.
"Everyone thinks it's only the gear, but the gear just enables us to use the speed characteristics. The gear itself has no technology value," he says, pointing out the GTF family also has a new core with an "industry-best" overall pressure ratio (OPR) of almost 50:1. This is achieved with fewer stages and a high-pressure (HP) compressor with a pressure ratio of 16:1, compared with 22:1 in the Leap-1, because of a higher pressure ratio in the faster-turning LP compressor. "Speed helps compression, so we can take parts out, and the LP turbine needs fewer airfoils to take the energy out," Saia says.
Speed also helps when it comes to temperatures, which drive component and maintenance costs. The PW1100G runs hotter than current A320 engines, but "significantly cooler" than the Leap-1A, says Saia. "You can either move more air slower or add more temperature, and it's cheaper to make power with air than temperature," he says. "We are not running exotic gas-path temperatures; we use the fundamental physics of speed." More conservative temperatures combined with advanced materials and cooling schemes allow Pratt to reduce HP turbine cooling-air flow 20%, he adds.
These differences may seem academic when both rivals promise similar fuel savings on the same platform, the market sets engine prices and maintenance-cost agreements ensure the manufacturers carry the risks of their technology choices. But they could become more significant as Pratt looks to expand its GTF applications to large commercial aircraft. On paper at least, the conservative temperatures and technologies in the PW1100G give Pratt plenty of room to grow.
Hess says the company has a technology road map to achieve 20-30% fuel savings over today's engines by the mid-2020s. The plan covers the complete engine from advanced aerodynamics and lightweight rotors for the fan, through higher gearbox ratios to increase bypass ratio, cores with OPRs beyond 60, active combustor control, and new materials and cooling schemes in the turbine. The road map is aimed at averaging a 1% per year reduction in sfc for new applications and capturing half of that improvement for re-insertion into existing engines, says Saia.
Notably absent from Pratt's road map are ceramic-matrix composites. CFM is introducing CMCs to commercial aircraft engines with a static part, the HP turbine first-stage shroud. "CMCs are a third the weight of metal, twice the strength and have 20% greater temperature capability. But it is not about higher temperature, it's about not having to use cooling air, which minimizes the loss of performance," says Gareth Richards, Leap program manager.
"We wanted to put CMCs in our fifth-generation fighter engines, but it was not cost-effective. They added a lot of product cost—they don't come for free," Saia says. Arguing there are still issues with cost and repairability of CMCs, he says Pratt is working on materials with different chemistry but similar properties "They are at TRL 5 (Technology Readiness Level). We have run them in subsystems. But we can get to 20-30% by the mid-2020s without CMCs."
GE and CFM, meanwhile, do not acknowledge any limitations on the conventional turbofan. GE will increase use of composites and CMCs in its GE9X for the Boeing 777X. CMC combustion-chamber liners, uncooled HP turbine nozzles, shrouds and, for the first time, blades are among technologies planned for the GE9X, which will have a 10% lower fuel burn than the GE90 powering today's 777-300ER. Others include a 27:1 pressure-ratio HP compressor. "Leap will have all the benefit of the technology from the GE9X and other development programs and we will introduce as it makes sense," says CFM. "We expect to be 2-3% better than the GTF and this is not a position we will relinquish."
Momentum behind GE's high-tech approach is building; more than $1 billion a year is going to develop, test and mature its commercial engine technology. Work on the GE9X began in 2010 and "the first 4-5 years are about demonstrating technology and producibility," says Bill Millhaem, GE90 general manager. "We will run the high-pressure compressor five years before certification," says Bill Fitzgerald, GE aviation vice president and general manager of the commercial engines operation. The first version begins test this month and two more are planned before design of the GE9X is frozen in 2015. "We will run CMC blades in 2014 in GENx demo engines."
|CFM INTERNATIONAL Leap-1A
|3-D woven composite, 18 blades, 78-in.-dia.
|Bi-metallic, 20 blades, 81-in.-dia.
|3:1 reduction
|LP compressor
|3 stages, variable-bleed valves
|3 stages, higher speed, fewer airfoils
|HP compressor
|10 stages
|8 stages
|TAPS II low-NOx, additive fuel nozzle
|Talon X low-NOx
|HP turbine
|2 stages, uncooled CMC shroud
|2 stages
|LP turbine
|7 stages, titanium-aluminide blades
|3 stages, titanium-aluminide blades, higher speed, fewer airfoils
|Sources: CFM International, Pratt & Whitney


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Green Fellows Learn Lessons from Research Experience
May 21, 2013
Jack Hunt, a chemistry major, applied what he learned at UT Dallas to disease-related research at UT Southwestern.
UT Dallas electrical engineering major Michelle Corn describes her junior year as "an amazing experience."
"I had the opportunity to be in an operating room during brain surgery and to work in a neuro-oncology laboratory, which is completely outside my area of study," Corn said.
Through the Green Fellows Program, Corn was one of a dozen UT Dallas students who recently completed a semester of full-time research with faculty mentors at UT Southwestern Medical Center in Dallas.
Working with mentors in the Advanced Imaging Research Center, Corn investigated how an aggressive type of brain tumor called a glioblastoma produces the energy it needs to grow. The research may lead to more effective therapies to increase the survival time of patients diagnosed with the tumors.
During the presentation of her research poster at UT Southwestern, the electrical engineering major was joined by her mother, Cindy Corn, who traveled from Austin, and grandmother Eleanor Fleming, who flew in from Chicago. "I was constantly learning new things about biology, oncology, chemistry and medicine," Corn said. "My ultimate career goal is to be a biomedical engineer, and I enjoyed this experience so much that medical school might be an option for me as well."
Participants in the Green Fellows Program spend 16 weeks pursuing individual research projects under the direction of UT Southwestern faculty. Fellows receive $4,000 and spend the entire semester focused on research.
During her research presentation at UT Southwestern, electrical engineering major Michelle Corn was joined by her mother, Cindy Corn, who traveled from Austin, and grandmother Eleanor Fleming, who flew in from Chicago.
"Working at UT Southwestern was the most fruitful academic experience I have had in college up to this point," said Jack Hunt, a chemistry major who also just completed his junior year. His research centered on developing a potential drug for African sleeping sickness, a disease endemic to sub-Saharan Africa that is fatal if left untreated. "I learned how to apply the theories and techniques that I was taught at UT Dallas; I learned how to be a chemist."
The 2013 participants are the eighth group of Green Fellows. Students interested in applying to the program must have completed their sophomore year, and be majoring in a science, engineering or computer science discipline at UT Dallas.
John Paul Harris, a junior biology major, said he will always be grateful for the experience.
"Being able to do research in a world-class lab with some of the most intelligent people on the planet was a great opportunity to really develop an analytical, scientific mindset, which will translate well in our future endeavors," said Harris, whose future plans include medical school. He studied the underlying mechanisms that lead to a normal human heartbeat, which contributes to a better understanding of how cardiac arrhythmias are generated.
"The quality of our undergraduates at UT Dallas has had a tremendous impact on our University," said Dr. A. Dean Sherry, a professor of chemistry at UT Dallas and co-director of the program. "They're remarkable. Many times they come into the lab and drive the work of graduate students."
Sherry, the Cecil H. and Ida Green Distinguished Chair in Systems Biology Science at UT Dallas, holds a dual appointment as a professor of radiology at UT Southwestern, where he also is director of the Advanced Imaging Research Center. He co-directs the Green Fellows Program with Dr. Nancy Street, associate dean of the Southwestern Graduate School of Biomedical Sciences and an assistant professor of microbiology at UT Southwestern.
"The Green Fellows have developed a superior reputation at UT Southwestern because they come here and perform," Street said. "Our faculty members love having them in their labs."
Sherry, whose research focuses on developing advanced imaging agents for use in MRI applications, said that he has welcomed many undergraduates to his laboratory over a 40-year career at UT Dallas.
"You can't help but like working with young students," he said. "It's just fun. When they're bright and enthusiastic, they're willing to work on anything. I still get a kick out of it."
Corn, Michelle
Alternative Sources of Energy Production in Human Gliomas
Dr. Duncan McFarlane, UT Dallas
Dr. Craig Malloy,
Advanced Imaging Research Center
Ding, Min-Sheng (Sam)
Investigating Genes that Interact with EWS-FLI1 in Ewing's Sarcoma with a Zebrafish Model
Dr. Dennis Smith,
Dr. James Amatruda, UT Southwestern
Elkassih, Sussana
Disruption of Endocytic Maturation Using Ph-Sensitive Nanoparticles Results in Nuclear Translocation of TFEB
Dr. Mihaela C. Stefan, UT Dallas
Dr. Jinming Gao,
Simmons Comprehensive Cancer Center
Graham, Eric
Regulation of Thrombin-induced Corneal Fibroblast Clustering by Matrix Rigidity and Cell Contractility
Dr. Paul Pantano,
Dr. Matthew Petroll,
Gupta, Natasha
Histological Characterization of Post-Synaptic Shank3 Deletion in Mouse Models of Autism
Dr. Susan Jerger,
Dr. Craig Powell,
Neurology and Neurotherapeutics
Harris, John Paul
Transcriptional Regulation in the Cardiac Conduction System by the Myogenic Repressor MyoR
Dr. Dennis Miller,
Dr. Nikhil Munshi,
Internal Medicine
Hunt, John (Jack)
Optimizing an Adenosine Analogue for the Treatment of African Sleeping Sickness
Dr. Bruce Novak,
Dr. Jef De Brabander, UT Southwestern
Im, Kwok Wai (Chris)
In Vitro Model Assay of Synaptic Dysfunction in Huntington's Disease
Dr. Thompson,
Dr. Ilya Bezprozvanny,
Kraft, Michael
Synthesis and Hyperpolarization of 13C-Labeled Malonic Acid Derivatives as Potential Ph-Sensitive Probes for Metabolic Imaging of Cancer
Dr. Dean Sherry
Advanced Imaging Research Center
Lee, Hyo Min
Rapid Magnetic Resonance Spectroscopic Imaging Using an Two-Dimensional "Flyback" Echo-Planar Trajectory
Dr. Dennis Miller,
Dr. Matthew Merritt, UT Southwestern
Advanced Imaging Research Center
Neill, Edward
A Unique Screening Platform to Identify Vaccine Candidates
Dr. Hyun-Joo Nam, UT Dallas
Dr. Ellen Vitetta,
Cancer Immunobiology
Rao, Anandini
Testing for an interaction between RCAN1 and the Toll Like Receptor Signaling Pathway
Dr. Dennis Miller,
Dr. Beverly Rothermel,
Internal Medicine
Media Contact: Amanda Siegfried, UT Dallas, (972) 883-4335, [email protected]
or the Office of Media Relations, UT Dallas, (972) 883-2155, [email protected]


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To draw something is to fully understand it — that's the rule Anita Lehmann lives by. So when the chance came to spend two months living and drawing in Italy, she took it. And what came from that was her new, first-ever book, "Drawing Lessons from Civita: An Artist's Adventure in Italy."
Lehmann is an artist, teacher and architect, but the common thread in all of her work is drawing. She works from her Queen Anne home, with a drawing studio for students downstairs and her architecture studio upstairs. She used to teach drawing and painting at the University of Washington. It was through a program there that she first discovered the tiny hillside town of Civita, Italy.
She spent three months there when she was 28, with a group of students, as a teacher's assistant teaching drawing. Now, a "whole other lifetime later," at age 56, she returned, to live and draw.
Lehmann was selected as one of the two fellows for the Civita Institute, based out of Seattle. She left mid-August 2013 and returned to Seattle in mid-October.
The Civita Institute was co-founded in 1981 by UW professor Astra Zarina as a way to foster intercultural communication and professional growth and enrichment, according to its website (www.niausi.com).
James Corey, president of the Civita Institute, experienced Civita's magic himself when he lived there for four months in '99. The trip changed his life, he said:
"The quality of life there is incredible, from the food to the camaraderie to the language and the arts. It's a transformative thing for people."
The institute has been sending mid-career people to live there for the last 30 years, to learn and bring that knowledge back to share with others.
Town became teacher
The town of Civita is tiny. It's only two city blocks long and one city block wide, Lehmann estimates. It sits atop a rocky hillside that's inaccessible by car. Each day, Lehmann would cross the bridge, pulling a cart, to get her groceries from the nearby market. She'd always remember to bring some carrots to feed the local donkey, Rufina.
With only about 16 permanent residents, Civita is often called a ghost city, Lehmann said, adding that people who visit often think they're visiting a museum or movie set.
"And then you walk out of your apartment and they go, 'You live here?'" she said. "In reality, there are people that live there and it's a vibrant town."
Lehmann went in with a proposal of what she wanted to accomplish.
"I was sort of coming in as a bossy American [saying], 'I'm going to do a drawing book about Civita,'" she said. "All of a sudden, Civita became the teacher."
She spent every day drawing, toting her portable REI stool and sketching supplies. When the afternoons got warm, she'd work in the studio the Civita Institute provided. She worked mostly in graphite and pen but colored some sketches with watercolor or pastels. Most of the drawings were descriptive, to give the viewer a sense of place. But eventually, she transitioned to the "artist realm" and did evocative drawings.
While she worked, Lehmann saw many tourists snapping pictures of their travels. But for her, the true power came from recording her memories in drawings. It's something she writes about in the book: how each drawing takes her back to the specific place, smells, tastes and feelings.
As Lehmann went back through the drawings, she compiled the lessons Civita taught her about drawing. Those lessons became the chapters of her book. In addition to the individual sketches, each day she added a sketch to a 30-foot scroll of paper that encompassed the "whimsy of Civita."
And she also created a series of comics about a bird named Willa and her adventures in Civita. This fall, she'll present the scroll and her other works for the Civita Institute.
Some parts of the books are practical, such as a list of what to take with you when you sketch on location, but others are more about the power of drawing. The drawings aren't perfect, but "it really does come from the heart," Lehmann said.
The biggest lesson Lehmann learned was "the power and joy of adventure and sharing it with others," she said.
No matter the place
When she returned to Seattle, Lehmann scanned the images into her computer. A friend helped her edit her writing, and another helped her design the book. She's selling the book on the self-publishing website Blurb, which prints the books as they're ordered. The finished version released in March.
"I've never seen someone with her fluidity and productivity," Corey said. "I was stunned. It's a great book."
"I think for [the institute], it's a beautiful presentation about the quality of what Civita brings," Lehmann said.
Next, Lehmann would like to visit Norway or Walla Walla, Wash. Or she may do a drawing-lessons book about Seattle — the place doesn't really matter. It's more about the experience: sitting on her tiny stool, recording the details of the beautiful surroundings and living her passion.
"Drawing Lessons from Civita: An Artist's Adventure in Italy" is available for purchase at http://www.blurb.com/b/5184804-drawing-lessons-from-civita.
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Gorilla Zoe Says He Used To Be A Dancer! "Ill Bust Chris Brown Out. Dont Play With Me Girl"
Gorilla Zoe interview
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Tanami Desert project aims to save the bilby
Remote sensor cameras are being set up in the Tanami Desert as part of a new study to save the bilby from extinction in Central Australia.
The project, run by the Northern Territory Land Resource Management Department and the Central Land Council, gives rangers the opportunity to place cameras near active burrows.
Richie Brittingham from the Central Land Council says unless researchers get funding for such projects, species such as the bilby will be lost forever.
"It's a loved species and I think the impact of actually losing that animal, on top of all the other medium-sized mammal species that we've lost from the continent, would be a terrible loss," he said.
"I think increased investment in particular species like this is very important."
He says governments need to prioritise funding for projects involving threatened species.
Warlpiri ranger Madeleine Dixon says the Tanami Desert study will give researchers insight into why the bilby is under threat.
"We are getting worried about the bilbies," she said.
"We are trying to bring the population up again."
About the size of a rabbit, bilbies are the largest member of a family called bandicoots.
Their numbers have been greatly reduced since European settlement and the introduction of feral predators.
How many of the animals remain is unknown but their burrows are largely restricted to certain areas of the Northern Territory, Western Australia and Queensland.
The bilby is classified as threatened in the Territory, endangered in Queensland and rare in Western Australia.
Topics: animals, environmental-management, alice-springs-0870, brisbane-4000, perth-6000


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Philosophy of Science: An Historical Anthology
Philosophy of Science: An Historical Anthology
ISBN: 978-1-405-17542-5 May 2009 Wiley-Blackwell 680 Pages
Download Product Flyer
- Provides a comprehensive history of the philosophy of science, from antiquity up to the 20th century
- Includes extensive commentary by scholars putting the selected writings in historical context and pointing out their interconnections
- Covers areas rarely seen in philosophy of science texts, including the philosophical dimensions of biology, chemistry, and geology
- Designed to be accessible to both undergraduates and graduate students
Table of contents
Notes on Editors
Personal Acknowledgments
Text Acknowledgments
Part I
Unit 1 The Ancient and Medieval Periods
1.1 Atoms and Empty Space: Diogenes Laertius
1.2 Letter to Herodotus: Epicurus
1.3 The Paradoxes of Motion: Zeno
1.4 Plato's Cosmology: Plato
1.5 The Structure and Motion of the Heavenly Spheres: Aristotle
1.6 Change, Natures, and Causes: Aristotle
1.7 Scientific Inference and the Knowledge of Essential Natures: Aristotle
1.8 The Cosmos and the Shape and Size of the Earth: Aristotle
1.9 The Divisions of Nature and the Divisions of Knowledge: Aristotle
1.10 On Methods of Inference: Philodemus
1.11 The Explanatory Power of Atomism: Lucretius
1.12 The Earth: Its Size, Shape, and Immobility: Claudius Ptolemy
1.13 The Weaknesses of Hypotheses: Proclus
1.14 Projectile Motion: John Philoponus
1.15 Free Fall: John Philoponus
1.16 Against the Reality of Epicycles and Eccentrics: Moses Maimonides
1.17 Impetus and its Applications: Jean Buridan
1.18 The Possibility of a Rotating Earth: Nicole Oresme
Unit 2 The Scientific Revolution
2.1 The Nature and Grounds of the Copernican System: Georg Joachim Rheticus
2.2 The Unsigned Letter: Andreas Osiander
2.3 The Motion of the Earth: Nicholas Copernicus
2.4 The New Star: Tycho Brahe
2.5 A Man Ahead of His Time: Johannes Kepler
2.6 On Arguments about a Moving Earth: Johannes Kepler
2.7 Eight Minutes of Arc: Johannes Kepler
2.8 Tradition and Experience: Galileo Galilei
2.9 A Moving Earth Is More Probable Than the Alternative: Galileo Galilei
2.10 The Ship and the Tower: Galileo Galilei
2.11 The Copernican View Vindicated: Galileo Galilei
2.12 The ""Corpuscular"" Philosophy: Robert Boyle
2.13 Successful Hypotheses and High Probability: Christiaan Huygens
2.14 Inductive Methodology: Isaac Newton
2.15 Space, Time, and the Elements of Physics: Isaac Newton
2.16 Four Rules of Reasoning: Isaac Newton
2.17 General Scholium: Isaac Newton
2.18 The System of the World: Isaac Newton
Unit 3 The Modern Period
3.1 The Inductive Method: Francis Bacon
3.2 Rules for the Discovery of Scientific Truth: René Descartes
3.3 Rationalism and Scientific Method: René Descartes
3.4 Human Knowledge: Its Scope and Limits: John Locke
3.5 The Principle of Least Action: Gottfried Wilhelm Leibniz
3.6 Space, Time, and Symmetry: Gottfried Wilhelm Leibniz
3.7 The Problem of Induction: David Hume
3.8 The Nature of Cause and Effect: David Hume
3.9 The Metaphysical Foundations of Natural Science: Immanuel Kant
Unit 4 Nineteenth and Early Twentieth Century
4.1 The Nature of Scientific Explanation: Antoine Lavoisier
4.2 Determinism, Ignorance, and Probability: Pierre-Simon Laplace
4.3 Hypotheses, Data, and Crucial Experiments: John Herschel
4.4 An Empiricist Account of Scientific Discovery: John Stuart Mill
4.5 Against Pure Empiricism: William Whewell
4.6 The Causes Behind the Phenomena: William Whewell
4.7 Catastrophist Geology: Georges Cuvier
4.8 Uniformitarian Geology: Charles Lyell
4.9 The Explanatory Scope of the Evolutionary Hypothesis: Charles Darwin
4.10 Induction as a Self-Correcting Process: Charles Sanders Peirce
4.11 The Nature of Abduction: Charles Sanders Peirce
4.12 The Role of Hypotheses in Physical Theory: Henri Poincaré
4.13 Against Crucial Experiments: Pierre Duhem
4.14 On the Method of Theoretical Physics: Albert Einstein
Part II
Unit 5 Positivism and the Received View
5.1 Theory and Observation: Rudolf Carnap
5.2 Scientific Explanation: Carl Hempel
5.3 Empiricism, Semantics, and Ontology: Rudolf Carnap
5.4 The Pragmatic Vindication of Induction: Hans Reichenbach
5.5 Dissolving the Problem of Induction: Peter Strawson
Unit 6 After the Received View: Confirmation and Observation
6.1 Empiricist Criteria of Cognitive Significance: Problems and Changes: Carl Hempel
6.2 The Raven Paradox: Carl Hempel
6.3 Two Dogmas of Empiricism: W. V. O. Quine
6.4 The New Riddle of Induction: Nelson Goodman
6.5 What Theories Are Not: Hilary Putnam
6.6 On Observation: N. R. Hanson
6.7 The Ontological Status of Theoretical Entities: Grover Maxwell
Unit 7 After the Received View: Methodology
7.1 Science: Conjectures and Refutations: Karl Popper
7.2 The Structure of Scientific Revolutions: Thomas Kuhn
7.3 Science and Pseudoscience: Imre Lakatos
Unit 8 After the Received View: Explanation
8.1 Counterexamples to the D-N and I-S Models of Explanation: Wesley Salmon
8.2 The Statistical Relevance Model of Explanation: Wesley Salmon
8.3 Why Ask, ""Why""?: Wesley Salmon
8.4 Explanatory Unification: Philip Kitcher
Unit 9 After the Received View: The Realism Debate
9.1 The Current Status of Scientific Realism: Richard N. Boyd
9.2 A Confutation of Convergent Realism: Larry Laudan
9.3 Constructive Empiricism: Bas van Fraassen
9.4 The Natural Ontological Attitude: Arthur Fine
""Overall, this is an impressive and versatile volume that should find its way into many classrooms. The commentary is thorough and clear enough to make the readings accessible to students, but not so imposing that instructors cannot add their own interpretation. This book would be suitable for advanced undergraduates who have completed previous coursework in history or philosophy."" (Science & Education, 4 March 2011)
- Provides a comprehensive history of the philosophy of science, from antiquity up to the 20th century
- Includes extensive commentary by scholars putting the selected writings in historical context and pointing out their interconnections
- Covers areas rarely seen in philosophy of science texts, including the philosophical dimensions of biology, chemistry, and geology
- Designed to be accessible to both undergraduates and graduate students


text:
Politics & Government
Battling a backlog, VA says it will speed decisions on some veterans' disability claims
The Department of Veterans Affairs, under fire for the sluggish pace of awarding disability benefits for wounded veterans, announced a new plan Friday to provisionally approve its oldest claims based on the evidence already in its files.
The VA said Friday it will begin to focus on claims that have been pending for more than a year – a good chunk of all the claims in the agency's massive backlog. Beginning immediately, the VA will make provisional decisions on those claims, allowing veterans to begin collecting benefits far sooner.
"We don't want veterans to have to wait any longer than necessary to get decisions on the benefits they've earned and deserve," Allison Hickey, the VA's undersecretary for benefits, said Friday in a conference call with reporters.
Veterans and their advocates have complained for years about the agency's slow decision-making process, and they've watched again and again as the VA promised improvements that never seemed to materialize. Veterans just back from the recent wars – as well as those who served in Vietnam, Korea or World War II – have waited months, or even years, for decisions that were often wrong and often required additional months or years of appeals.
The provisional decisions on claims will be based on all evidence the VA has received to date – information either from the veteran or developed by the VA. Those provisional decisions will note the evidence the VA used and what has yet to be provided, and the veteran will begin receiving benefits immediately.
Veterans then will have up to a year to submit additional evidence to the file if they are seeking to boost their benefits. If no additional information comes in, the decision will be considered final, although veterans have a right to appeal such decisions.
The VA also said that these older cases will get expedited medical exams if needed for the claim to be approved.
The agency's disability benefits are awarded to veterans who suffer physical or mental injuries during their military service. They range from $129 a month to $2,816 a month for a single veteran.
But although the VA has pledged for years to give veterans swift and accurate decisions on their claims, in recent years the agency has rarely met its goals to do so.
Swamped by claims from recent Iraq and Afghanistan veterans, as well as those from earlier wars, the VA's backlog of cases has swelled. Incoming claims have jumped to more than 1 million a year.
The VA's ambitious goals are to have all claims decided in 125 days or less and with errors in just 2 percent of claims. The VA has said it's on track to meet these goals by 2015, in part due to changes made in the regional offices that decide the claims.
The most recent fiscal year, however, showed an error rate of 14 percent. And the most recent numbers show that of more than 800,000 claims awaiting decisions, 70 percent have been pending more than 125 days.
In addition, the department's closely tracked figure for the average days necessary to complete each claim jumped to 262 last year – the highest that measure has been in at least the past 20 years for which numbers were available.
Even if the latest initiative is successful, it actually will make some of the numbers worse in the short term. As the VA decides the oldest claims on its books, the average-days-to-complete number will jump, as the old claims pull up the overall numbers. Over time, however, the VA said the numbers will come down as the VA finally takes care of those oldest claims.


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Republicans are crying foul – and raising the memory of Watergate – over the release of an embarrassing secret recording of a strategy session for the reelection campaign of Sen. Mitch McConnell (R) of Kentucky. Senator McConnell, the top Republican in the US Senate, was present at the meeting.
Audio from the Feb. 2 meeting, posted Tuesday on the liberal Mother Jones website, included discussion of (and laughter over) past comments and travails of actress Ashley Judd, who had considered running against McConnell but decided not to.
The McConnell campaign denies that anyone on its staff leaked the recording.
"Secret recordings, private conversations leaked, reports of bugs – these Watergate-era tactics have no place in our campaigns," Sen. Jerry Moran (R) of Kansas, chairman of the National Republican Senatorial Committee, said in a statement.
The McConnell campaign is working with the Federal Bureau of Investigation and has notified the US Attorney's office in Louisville about the matter, McConnell's campaign manager, Jesse Benton, told NBC News.
The incident brings to mind the secret video recording last year of GOP presidential candidate Mitt Romney talking about the "47 percent" – people who will vote for President Obama "no matter what" and are "dependent upon government" – also posted on the Mother Jones site. That video may have been the most damaging moment in Romney's campaign.
But in legal terms, the McConnell recording is different. Mr. Romney was speaking at a fundraiser in Florida, and while it was a private event, he could reasonably expect that he might be recorded.
In McConnell's case, campaign staffers – and the senator himself – could have a reasonable expectation of privacy when meeting behind closed doors. So the making of the recording could be illegal.
Kentucky law states that a person is guilty of eavesdropping – a felony – "when he intentionally uses any device to eavesdrop, whether or not he is present at the time." Kentucky law defines the term "eavesdrop" as meaning "to overhear, record, amplify, or transmit any part of a wire or oral communication of others without the consent of at least one party thereto by means of any electronic, mechanical, or other device."
"If there was no consent by anybody, it would seem as though whoever planted the tape could be charged with eavesdropping under Kentucky law," says Joshua Douglas, a law professor at the University of Kentucky, Lexington.
As a political story, the most salient point may not be the discussion of Ms. Judd's potential vulnerabilities as a candidate – including her mental health history and her views on religion. After all, we now know Judd's not running. It could be the fact that the recording shows that, as of Feb. 2, the McConnell campaign didn't have much on another possible opponent, state Attorney General Alison Lundergan Grimes, notes Washington Post political blogger Chris Cillizza.
"The best hit we have on her is her blatantly endorsing the 2008 Democratic national platform," says one attendee at the meeting.
"Translation: McConnell doesn't have much on Grimes," writes Mr. Cillizza. "Attacking her as a tool of President Obama might do some damage, but as we've seen in recent years – Jon Tester in Montana, Heidi Heitkamp in North Dakota – simply linking a Democrat in a conservative state to Obama isn't a foolproof strategy for victory."
Tuesday afternoon, the Democratic Senatorial Campaign Committee jumped into the fray, calling on McConnell to apologize for using "taxpayer-funded legislative aides" to conduct campaign opposition research and for "insulting millions of Americans who suffer from depression."
On the recording, campaign staffers were heard discussing Judd's battles with depression, which she wrote about in her 2011 memoir, "All that is Bitter & Sweet."


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Search For Properties In Lake Wyman Enclave
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Lake Wyman Enclave is a community consisting of luxury townhomes in a private enclave along the intracoastal waterways. This exclusive collection of townhomes enjoys immediate access to the beach and picturesque views of surrounding scenery.
Real Estate: Lake Wyman Enclave luxury real estate includes six townhomes situated along the intracoastal waterways of Boca Raton. Each townhome is over 3,000 square feet and enjoys the privacy and luxuries of this waterfront community. Estate properties in Lake Wyman Enclave include features such as a private pool, a boat dock, a second-story patio, state-of-the-art appliances, updated rooms, granite countertops, and much more.
Lifestyle: Residents of Lake Wyman Enclave are just steps from their own private gated beach, and can access the activity of downtown Boca Raton in a matter of minutes. This is a desirable primary or secondary residence for water sports enthusiasts, due to its immediate access to the intracoastal waterways and proximity to the waters of the Atlantic. Parks, restaurants, boutiques and other attractions are all within a reasonable distance of this centrally located community.
Education: Lake Wyman Enclave residents are located near several area public schools, including J.C. Mitchell Elementary School, Boca Raton Community Middle School, and Boca Raton Community High School. Nearby private schools include Grandview Preparatory School and Saint Ambrose.
Water Access: Due to Lake Wyman Enclave's location on Boca Raton's intracoastal waterways, residents may conveniently access the ocean on their yacht or boat parked at their private dock. They may also walk to their own private white sand beach in a matter of minutes


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British music legends Inspiral Carpets will be in action at The Venue in Derby on Wednesday, November 4, as part of a mini-tour of the UK.
The show follows on from their first studio album for 20 years, which in turn was followed by a successful album tour in December 2014.
The Manchester band released their fifth studio album after signing to Cherry Red Records.
From the album, the band released the singles Spitfire and Let You Down, a collaboration with Manchester punk poet John Cooper-Clarke, who co-wrote and performed on the song.
Graham Lambert from Inspiral Carpets said: "We equally love doing the festivals and live club shows.
"We don't tour all the time and last year was truly magical.
"This year is stacking up to be on par.
"We have the Shed Seven dates later in the year but it's great to be going back to Derby"
The Venue is based at 47-49 Abbey Street, Derby.
The age limit for the gig is 18-plus and doors open at 7.30pm.
For ticket availability, call 01332 203545 or go to http://www.livemusicderby.co.uk


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flexi Vario Tape Lead Large – Red 8m – Multi Box – Red
The large flexi Vario Tape Lead is part of the new generation of retractable dog leads from flexi. This innovative lead has been carefully designed down to the very last detail offering your dog maximum freedom of movement while still leaving you in control. The vibrant red handle is comfortable to hold and the robust tape lead makes this product suitable for high-spirited dogs weighing up to 28kg or for calmer dogs up to 50kg with normal activity levels. The tape lead is extendable up to 8 metres and automatically rolls back into the casing as you get closer to your dog preventing the lead from dangling on the ground. The patented tape guidance system integrated into the handle also stops the lead from twisting or snagging. If you need extra control you can reduce the distance your dog is able to roam by activating the short-stroke braking system just at the touch of a button. The ergonomic handle is fully adjustable in size making it extra comfortable to hold. The soft elements of the casing also give it a pleasant feel and a good grip. The great range of matching functional accessories available lets you customise the flexi Vario Tape Lead to suit your individual needs. You can attach alternative tape leads like the red light-up LED Flash Belt using the patented multi-belt link system. The removable Multi Box means that you can always keep poop bags or dog treats to hand while the attachable LED Lighting System will brighten up walks at night or when visibility is poor. More information about the flexi Vario Accessories can be found here. flexi Vario Tape Lead Large – Red 8m at a glance 8m retractable tape dog lead with an innovative design Size L with tough tape lead for dogs with normal activity levels weighing up to 50kg or for lively dogs up to 28kg Tape guidance system ensures that the lead rolls smoothly in and out of the casing prevents twisting or snagging Short-stroke braking system a simple touch of the button is enough to stop and secure the lead helps you to control your dog as required Comfortable handle adjustable size ergonomic design comfy to use Patented multi-belt link system different tape leads can be interchanged using the simple 'click-and-go' system Functional accessories dog lead can be customised with these handy extras (not included in delivery) LED Flash Belt with permanent or flashing red light for extra safety Multi Box removable holder for dog treats or poop bags LED Lighting System bright light for better visibility in the dark
Specification: flexi Vario Tape Lead Large – Red 8m – Multi Box – Red
Multi, Red
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DocuSign + FreshBooks New Integrations
In a matter of minutes and without a single line of code, Zapier allows you to connect DocuSign and FreshBooks New, with as many as 40 possible integrations. Are you ready to find your productivity superpowers?
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Triggers when an envelope is sent or completed. NOTE: This trigger only checks for new envelopes every 15 minutes.
Creates an Invoice.
Triggers when a new folder is created.
Creates other income (i.e., income that doesn't require an invoice and is received through other means).
Triggers when a new client is created.
Update an existing invoice based on invoice number. Optionally create a new invoice if one does not exist.
Triggers when a new payment is created.
Creates a signature request.
Triggers when a new invoice is created. This trigger only returns a summary of the invoice, as the line items aren't included.
Creates new project.
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Hi everyone, it has been quite a while since my last post as I have been quite busy over the last few weeks!
Here is my work in progress on Country Cottage Needleworks. I have actually worked on this since I took this picture and it is now nearly finished!
More pictures below
I have a couple of private exchanges arranged over the next few months which should be fun, I have just received one from my friend Yana in Russia, although I am going to wait until my next post to show the pictures, just wait until you see them, as the gifts Yana sent are gorgeous! I sent Yana's exchange three weeks ago and she has not received it yet, but Yana has assured me that sometimes parcels can take 4 weeks from England, fingers crossed that it arrives safely.
I had a lovely 50th birthday, I received a beautiful gift from Jill at Purple Peacock blog here, Jill is so generous, I was totally amazed at the beautiful goodies Jill sent me, thankyou so much Jill!
Enclosed were some gorgeous silk threads, pins and needles and some tatting thread.
Here are the threads close up, they are lovely colours!
Here is a picture of the beautiful card my friend Diane sent to me, isn't it lovely!
And this is the lovely bouquet of flowers my son sent to me.
My husband bought me a beautiful watch.
Here is a lovely biscornu made by Connie using one of my patterns, it actually is a pattern for a little pillow but Connie had a good idea to make it into a biscornu - it has turned out beautiful don't you think?
This is the back of the biscornu, this part was designed by Connie.
You can find Connies blog here
Until next time, have a lovely stitchy week!


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Another source noted the family held a manor at Thakeham as early as 1347. [2]CITATION[CLOSE]
Lowe, Mark Anthony, Patronymica Britannica, A Dictionary of Family Names of the United Kingdom. London: John Russel Smith, 1860. Print. This latter entry is presumably referring to Apsley Farm at Thakeham. It should also be noted that Aspley is a township, in the parish of Eccleshall, union of Stone in Staffordshire and a hamlet in the parish of Wootton-Wawen, union of Stratford in Warwickshire and Aspley-Guise (Aspely End) is a parish in the union of Woburn, hundred of Manshead in Bedfordshire.
The Bedfordshire parish dates back to 1330 when it was first listed as simply Aspele in 1230 and literally meant "aspen-tree wood," from the Old English "aespe" + "leah." [3]CITATION[CLOSE]
Mills, A.D., Dictionary of English Place-Names. Oxford: Oxford University Press, 1991. Print. (ISBN 0-19-869156-4)
Aspey, Herefordshire is a 19th century mill village. Apsley House, also known as Number One, London, is the London townhouse of the Dukes of Wellington.
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The UK is going LTE
UK mobile operators, communications regulator Ofcom, and the government have agreed to start rolling out LTE in early 2013. The goal is for high speed data connectivity to launch by spring, approximately six months earlier than originally planned, providing consumers with quicker speed while using Internet services on smartphones.
EE (Everything Everywhere) has already been given the green light in 'switching on' its LTE network at multiple locations across the country ahead of the competition. To the dismay of the other carriers, EE aims to have 16 cities with LTE speeds by this Christmas, providing 20 million customers with a significant increase in speeds.
It's good news for consumers nationwide who will be able to enjoy faster speeds when upgrading mobile phones (should currently owned handsets not be able to take advantage of the standard). Ofcom notes that it had secured the earlier release of frequencies that were previously used for digital-terrestrial broadcasting so this deal could go ahead and improvements / upgrades to infrastructure be made sooner.
A spokesperson from Three UK had the following to add to the concluded deal:
"We see this as positive step for UK consumers by removing the monopoly on LTE that would have benefitted just one operator."
Announced Windows Phones from HTC and Nokia will be able to take full advantage of increased speeds with LTE in the UK. EE will be carrying both the Lumia 820 and Lumia 920 - both sporting LTE support. The HTC 8X will also be capable of transmitting and receiving packets at higher speeds, while the Samsung ATIV S can humorously "Bend it like Beckham." Three UK has revealed plans to stock both HTC devices, which will be mimicked by O2.
Are you looking forward to LTE coverage in the UK, or are you struggling to get by on 3G? Let us know your thoughts in the comments.


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Landing Page Code Broken
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Feb 14 2017, 11:23 AM
Post #1
Group: Members
Posts: 1
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Hi All,
I really need some of your expertise in fixing mylanding pages. I have absolutely no clue what happened to make them look so wonky all of a sudden. I used a HTML template as my knowledge of the language is novice at best. Everything looked at worked great! Here is what it looked like a few days ago:
Working page
I needed to make a few text edits to the page and suddenly found it looking like this:
Broken page
Not exactly sure what happened...How can I get this looking back the way it did? Here is the HTML/CSS code I'm using.
I know its a tall order and quite a few lines of code. I really appreciate any and all help guys. Thank you.
|Lo-Fi Version
|Time is now: 16th October 2019 - 06:43 AM


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My dear children, all I ask for this year is that you freeze this moment in our lives together. I am weary from trying to hold onto something that is not mine to keep.
Wrap me the things you define as treasures and place them under our tree with care. A soda pop lid from your collection, one of those cards I'm always screaming at you to pick up, that sock exactly the way it smells at this moment, the ringing of your laughter when you don't think I am listening.
I am always listening, my little loves, even when I am not there. You resonate through the marrow in my bones. There is nothing else in the world that I can hear but you.
Today you are perfect, as you were every yesterday and will be every tomorrow. Please, package yourselves for me with ribbons and bows, each exactly the person you are at this moment, because tomorrow you will be different and I cannot bear the losing of one more you to a new day's promise.
Promise me you'll continue to believe in magic you know for certain doesn't exist. Try your hardest to have faith where there ought be none. Know something in this life to be true simply because you decided one Tuesday morning that it should be. Myths are simply dreams we refuse to forget because they make us happy, nothing more. Remember how to believe, though belief is never sensible and rarely probable, but is almost always red and white and pepperminty. There is no reason why.
Algebra and faith are the most important things you will ever learn.
That, and that your mother loves you. You are my sun, my moon, and my star, and I could never ask for anything else as long as we all shall live.


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Freddie Mac has announced today (via Seeking Alpha) that thanks to QE3, it is boosting its outlook for the US housing market.
Here's the full announcement below the dotted line
The Federal Reserve took an important step when it announced an expansion of its Maturity Extension Program on September 13. Referred to in the media as "QE3" -- the third round of Quantitative Easing – the Federal Reserve stated that it would increase its purchases of agency mortgage-backed securities (MBS) by $40 billion per month and continue the 'term extension' of its portfolio; taken together, its holdings of longer-term securities will increase by about $85 billion per month through year-end. Its stated goal is to encourage lower long-term interest rates, especially on fixed-rate mortgages, and spark a further pick-up in housing activity. With QE3 in motion we have revisited our economic and housing market projections for the remainder of this year and for 2013. Moreover, the increased housing demand stimulated by QE3 may partly offset (albeit by a small amount) the substantial reduction in 2013 aggregate demand that would be expected if the so-called "fiscal cliff" occurs.
The housing sector's performance since the Great Recession of 2008-09 has been unlike any other economic recovery over the last 65 years. Typically, the housing industry leads the recovery charge helping to strengthen the early stages of the macroeconomic expansion. Yet housing has been the laggard during the current recovery. In fact, residential fixed investment (RFI) (the component of gross domestic product (GDP) that includes expenditures on new housing construction, additions and alterations to the existing housing stock, and broker commissions on property sales) was a net drag on GDP growth during 2006-2010 and added less than one-tenth of a percentage point to GDP growth in 2011. This year has been different; RFI added 0.3 percentage points to the first-half 2012 real GDP growth of 1.7 percent (annualized) and will likely add a similar boost during the
second half of the year.
The gradual turnaround in housing activity reflects, in part, the Federal Reserve's accommodative monetary policy. With mortgage rates at their lowest levels since at least the 1940s, housing demand has begun to improve. New housing starts were up 25 percent and existing home sales gained 8 percent over the first eight months of 2012 compared with the same period last year. Property value indexes for the U.S. have also turned up, with the FHFA purchase- only house price index up 3.8 percent over the 12 months through July and the National Council of Real Estate Investment Fiduciaries' value index for apartment buildings up 7.6 percent over the four quarters through mid- 2012.
Low mortgage rates have also spiked a refinance boom, with roughly three-fourths of all loan applications this year for refinance. For loans funded by Freddie Mac during the second quarter, the average borrower that refinanced lowered their mortgage rate by about 1.5 percentage points. For an average $200,000 loan, that translates into a savings in monthly payments of about $2,100 over the next year. Our new projection for the market as a whole for 2012 has about 7 million borrowers refinancing; if each experiences this average payment reduction then that will result in an aggregate of $15 billion in mortgage payment savings over the first 12 months after the refinance, a substantial infusion of funds to help strengthen savings and consumption spending by owners.
We have boosted our projection of single-family mortgage originations for the remainder of this year and for 2013 for two main reasons. First, the September release of the 2011 Home Mortgage Disclosure Act (HMDA) data (which includes purchase-money, refinance, and home-improvement loans), has led to an upward revision in our estimate of 2011 origination volume. Lenders covered under HMDA reported $1.43 trillion in originations for 2011; assuming HMDA covered about 95 percent of all volume in 2011, this equates to about $1.50 trillion in originations. The larger volume for 2011 also increased our estimate for 2012 because the latter is based, in part, on our estimates of purchase-money and refinance growth between the two years.
Second, the expectation of an extended period of low mortgage rates ushered in by QE3 has resulted in our boost to the new purchase-money and refinance volume during the second half of 2012 and into 2013. We expect single-family origination volume to come in close to $2 trillion in 2012, about a 30-percent rise from 2011, and then drop by 15 to 20 percent in 2013 as refinance 'burnout' and somewhat higher mortgage rates during the latter half of next year lead to less refinance activity.
The Federal Reserve's QE3 initiative will take on even more importance if the assortment of temporary tax cuts are allowed to expire at year-end and government spending levels are reduced with the start of 2013. Popularly known as the "fiscal cliff," these items include (but are not limited to) the expiration of the 2 percentage-point payroll-tax cut and Bush-era tax-rate reductions, and the spending cuts related to long-term unemployment benefits and automatic reductions required under the Budget Control Act of 2011.
The Congressional Budget Office has estimated that if all the temporary tax cuts expire and government spending levels are reduced, that 2013 GDP growth would be reduced by at least 2.2 percentage points from what it otherwise would have been, possible pushing the U.S into recession with unemployment rising to 9 percent. Moody's Analytics also concluded the economy would be much weaker in 2013 in such a scenario, with growth estimated to be 2.8 percentage points slower and unemployment rising to 9.2 percent.1 With QE3 already in place and helping to bolster housing demand in the near term, the economic effects of experiencing the "fiscal cliff" will be somewhat less than they otherwise would be.


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Evaluating the Genetic Causes and Progression of Cholestatic Liver Diseases (LOGIC) (LOGIC)
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT00571272
Recruitment Status : Recruiting
First Posted : December 11, 2007
Last Update Posted : August 7, 2019
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
|Condition or disease
|Liver Diseases Alagille Syndrome Alpha 1-Antitrypsin Deficiency
Cholestasis is a rare condition that involves a reduction or obstruction of bile flow from the liver to the small intestine. When bile flow is hindered, a waste product pigment called bilirubin can escape into the bloodstream and build up to harmful levels. This may lead to the easily recognizable cholestatic symptoms of jaundice, itching, and impaired growth and eventually to more serious health problems. Four rare genetic liver disorders— ALGS, a-1AT, bile acid synthesis and metabolism defects, and PFIC—account for about 20% to 30% of all infant cases of cholestasis. These four disorders compose a group of related diseases that can cause significant growth problems during childhood, serious liver problems, the need for liver transplantation, and potentially death. More research on these rare liver diseases is necessary to develop a scientific basis for improvement in diagnostic techniques and treatments. Current diagnostic procedures are complex, and the development of simpler diagnostic tests would facilitate early diagnosis and treatment. This study will investigate the natural history and progression of the four previously mentioned cholestatic liver diseases to provide a better understanding of the causes and effects of the diseases.
Participation in this study will last 20 years and will consist of a baseline visit and 20 annual follow-up visits. The study will enroll infants through adults 25 years of age who have, or are suspected of having, one of the four genetic cholestatic liver diseases. Individuals who are siblings of a-A1T participants and have underlying disease with no evidence of liver involvement may also be enrolled. Study visits will involve review of clinical information, family history, and any clinically indicated treatments and their outcomes; a physical exam; laboratory tests; and radiologic and imaging evaluations. In addition to these standard of care evaluations, participants will undergo several special research evaluations, including quality of life questionnaires, neurodevelopmental evaluations, hearing exams, liver histology studies, and collection of serum, plasma, urine, and blood for DNA. Serum, plasma, and blood for DNA will also be collected from both biological parents and from affected siblings of participants with a-A1T or ALGS. Genetic testing will be performed using the collected specimens.
|Study Type :
|Estimated Enrollment :
|1675 participants
|Observational Model:
|Time Perspective:
|Official Title:
|Longitudinal Study of Genetic Causes of Intrahepatic Cholestasis
|Study Start Date :
|November 2007
|Estimated Primary Completion Date :
|May 2024
|Estimated Study Completion Date :
|May 2024
Infants less than 6 months old with a cholestatic liver disease who were initially enrolled into the Childhood Liver Disease Research and Education Network (ChiLDREN) Prospective Biliary Atresia Epidemiology study (PROBE study; P003)
Participants with a cholestatic liver disease who are between birth and 25 years old who were NOT initially enrolled into the Childhood Liver Disease Research and Education Network (ChiLDREN) Prospective Biliary Atresia Epidemiology study (PROBE study; P003)
Post-liver transplant participants with a cholestatic liver disease who are between 1 day and 25 years old. Affected parents of patients enrolled in the study are eligible for enrollment if they are 25 years old or less
A screening group of participants, birth through 25 years old, suspected of having ALGS, PFIC (or BRIC) or BAD, who do not meet complete enrollment criteria for Group 1, 2, or 3.BRIC)
Affected siblings (without evidence of liver disease) of Alpha-1 Antitrypsin Deficiency participants who are enrolled in LOGIC.
- Demonstration of disease progression for each of the four cholestatic liver diseases of the study, including liver transplantation, death, growth failure, worsening liver function, and developmental complications of portal high blood pressure [ Time Frame: Measured at baseline and annually through year 10 ]
- Jaundice (total serum bilirubin of greater than 2.0 mg/dl) [ Time Frame: Measured at baseline and annually through year 10 ]
- Listing for liver transplantation [ Time Frame: Measured at baseline and annually through year 10 ]
- Calculated Pediatric End-Stage Liver Disease (PELD) score for participants less than 12 years of age or Model for End-Stage Liver Disease (MELD) score for participants 12 years of age or older [ Time Frame: Measured at baseline and annually through year 10 ]
- Health related quality of life [ Time Frame: Measured at baseline and annually through year 10 ]
- Growth (length and weight Z-score) [ Time Frame: Measured at baseline and annually through year 10 ]
- Bone mineral density (lumbar and spine total body) [ Time Frame: Measured at baseline in ALGS and PFIC/BRIC subjects ]
- Presence of hearing loss (ALGS and PFIC) [ Time Frame: Measured at baseline ]
Biospecimen Retention: Samples With DNA
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|up to 25 Years (Child, Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
|Sampling Method:
|Non-Probability Sample
Inclusion Criteria:
- Children and young adults diagnosed with one of the four cholestatic diseases from birth through 25 years old.
- Siblings of participants with alpha-1-antitrypsin deficiency, who themselves have alpha-1-antitrypsin deficiency of liver disease.
- Both genders, all races and ethnic groups
- Participant meets the enrollment criteria for one of the four cholestatic liver diseases
Exclusion Criteria:
- Inability to comply with the longitudinal follow-up described below, or
- Failure of a family/patient to sign the informed consent document or the HIPAA medical record release form.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00571272
|Contact: Terese Howell, BS, CCRC
|Contact: Joanne Lord, BA, LPN, CCRC
|United States, California
|Children's Hospital of Los Angeles
|Los Angeles, California, United States, 90027
|Contact: Catherine Goodhue, CPNP 323-361-4566 firstname.lastname@example.com
|Principal Investigator: Kasper Wang, MD
|Sub-Investigator: Nisreen Soufi, MD
|Sub-Investigator: Sonia Michail, MD
|Sub-Investigator: Danny Thomas, MD
|Sub-Investigator: Rohit Kohil, MD
|University of California at San Francisco (UCSF)
|Active, not recruiting
|San Francisco, California, United States, 94143
|United States, Colorado
|Children's Hospital Colorado
|Aurora, Colorado, United States, 80045
|Contact: Michelle Hite 720-777-4690 email@example.com
|Contact: Matthew Steinbeiss 720-777-4800 firstname.lastname@example.com
|Principal Investigator: Ronald J. Sokol, MD
|Sub-Investigator: Cara Mack, MD
|Sub-Investigator: Michael Narkewicz, MD
|Sub-Investigator: Shikha Sundaram, MD
|Sub-Investigator: Amy Feldman, MD
|Sub-Investigator: Dania Brigham, MD
|United States, Georgia
|Children's Healthcare of Atlanta - Emory University
|Atlanta, Georgia, United States, 30322
|Contact: Jeanette McFall 404-785-0421 email@example.com
|Principal Investigator: Saul Karpen, MD, PhD
|Sub-Investigator: Nitika Gupta, MD
|Sub-Investigator: Rene Romero, MD
|Sub-Investigator: Miriam Vos, MD, MSPH
|United States, Illinois
|Ann & Robert H. Lurie Children's Hospital of Chicago
|Chicago, Illinois, United States, 60611
|Contact: Susan M. Kelly, RN, BSN 312-227-3523 email@example.com
|Contact: Mary Riordan, CCRP 312-227-4558 email@example.com
|Principal Investigator: Estella Alonso, MD
|Sub-Investigator: Lee Bass, MD
|United States, Indiana
|Riley Hospital for Children
|Indianapolis, Indiana, United States, 46202
|Contact: Ann Klipsch, RN 317-944-9605 firstname.lastname@example.com
|Contact: Cindy Sawyers 317-944-1421 email@example.com
|Principal Investigator: Jean Molleston, MD
|Sub-Investigator: Molly Bozic, MD
|United States, Maryland
|Johns Hopkins University Hospital
|Baltimore, Maryland, United States, 21287
|United States, Missouri
|St. Louis University - Cardinal Glennon Children's Medical Center
|Saint Louis, Missouri, United States, 63104
|Contact: Shraddha Patel, Ph.D. 314-268-2700 ext 1095 firstname.lastname@example.com
|Principal Investigator: Jeff Teckman, MD
|Washington University School of Medicine/St. Louis Children's Hospital
|Saint Louis, Missouri, United States, 63110
|United States, New York
|Mount Sinai School of Medicine
|New York, New York, United States, 10029
|United States, Ohio
|Cincinnati's Children's Memorial Hospital
|Cincinnati, Ohio, United States, 60190
|Contact: Julie Denlinger, RN, BSN 513-636-7818 email@example.com
|Principal Investigator: Jorge Bezerra, MD
|Sub-Investigator: James Heubi, MD
|Sub-Investigator: Alexander Miethke, MD
|Sub-Investigator: Joseph Palermo, MD
|United States, Pennsylvania
|Children's Hospital of Philadelphia
|Philadelphia, Pennsylvania, United States, 19104
|Contact: Jessi Erlichman, MPH 215-590-2525 firstname.lastname@example.com
|Contact: Iraklis Petrof 267-426-8613 email@example.com
|Principal Investigator: Kathy Loomes, MD
|Sub-Investigator: David Piccoli, MD
|Sub-Investigator: Elizabeth Rand, MD
|UPMC Children's Hospital of Pittsburgh
|Pittsburgh, Pennsylvania, United States, 15224
|Contact: Kathryn Bukauskas, RN, CCRC 412-692-7703 firstname.lastname@example.com
|Contact: Adam Kufen, RN, CCRC 412-692-6558 firstname.lastname@example.com
|Principal Investigator: Robert Squires, MD
|Sub-Investigator: Patrick Mckiernan, MD
|Sub-Investigator: James Squires, MD
|United States, Texas
|Baylor School of Medicine
|Houston, Texas, United States, 77030
|Contact: Laurel Cavallo 832-822-1053 firstname.lastname@example.com
|Contact: Cynthia Tsai, MPH 832-822-3634 email@example.com
|Principal Investigator: Paula Hertel, MD
|Sub-Investigator: Benjamin Shneider, MD
|United States, Utah
|University of Utah
|Salt Lake City, Utah, United States, 84113
|Contact: Stephen Guthery, MD 801-213-3599 email@example.com
|Contact: Ann Rutherford 801-585-9495 firstname.lastname@example.com
|Principal Investigator: Stephen Guthery, MD
|United States, Washington
|Seattle Children's Hospital
|Seattle, Washington, United States, 98105
|Contact: Melissa Young 206-987-1037 email@example.com
|Principal Investigator: Karen Murray, MD
|Sub-Investigator: Simon Horslen, MD
|Sub-Investigator: Evelyn Hsu, MD
|Canada, Ontario
|The Hospital for Sick Children
|Toronto, Ontario, Canada, M5G 1X8
|Contact: Deepika Sharma 416-813-7654 ext 201594 firstname.lastname@example.com
|Contact: Claudia Quammie 416-813-7654 ext 201594 firstname.lastname@example.com
|Sub-Investigator: Vicky Ng, MD
|Principal Investigator: Binita Kamath, MD
|Study Chair:
|Kathleen Loomes, MD
|Children's Hospital of Philadelphia
|Study Director:
|Ed Doo, MD
|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
|Principal Investigator:
|John Magee, MD
|University of Michigan
|Principal Investigator:
|Robert Merion, MD
|Arbor Research Collaborative for Health
|Study Director:
|Averell Sherker, MD
|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Additional Information:
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Cholestatic Liver Disease
Childhood Diseases
Genetic Diseases
Bile Acid Synthesis and Metabolism Defects
Progressive Familial Intrahepatic Cholestasis
Liver Diseases
Alpha 1-Antitrypsin Deficiency
Alagille Syndrome
Digestive System Diseases
Bile Duct Diseases
Biliary Tract Diseases
Lung Diseases
Respiratory Tract Diseases
Genetic Diseases, Inborn
Subcutaneous Emphysema
Pathologic Processes
Cholestasis, Intrahepatic
Heart Defects, Congenital
Cardiovascular Abnormalities
Cardiovascular Diseases
Abnormalities, Multiple
Congenital Abnormalities


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The Sigma Chi Fraternity has recognized more than 1,500 brothers with the Significant Sig Award since its inception at the 1935 Grand Chapter. Alumni in any profession, occupation or service work are eligible for consideration.
Any Sigma Chi alumnus or undergraduate may nominate a brother for the Significant Sig award. A nomination consists of a completed nomination form, and a resume or summary of the nominee's past and present occupations and positions, professional and/or civic activities, and honors or awards received. Service to Sigma Chi as an undergraduate or alumnus is not a criterion for this award, and ought not to be listed. If a candidate is selected, a nominator may be asked to assist the alumni services department at International Fraternity Headquarters with coordinating an awards ceremony. Only living members of the Fraternity are eligible to receive the award.
The Fraternity's awards committee reviews Significant Sig Award nominations annually. Nominations are due Nov. 15 of each calendar year. Nominators are notified of the committee's decision by March 15 of the following year. You can access the nomination form by visiting foundation.sigmachi.org. Dates to remember:
Nomination form due: Nov. 15
Nominator notification: March 15
Earliest award ceremony: April 15


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Street Rappers / Smugglaz (Thug Life In Canada) [Full CBC Documentary]
CBC National News documentary about thug life in Toronto's Jane-Finch. Shout out to Kevin for sending us this
Please click the "Report" button below if the video on this page is not working properly.
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text:
Nation & World
Obama's troop announcement could have big repercussions
WASHINGTON — Nearly 10 years after a U.S.-led coalition attacked Afghanistan and 18 months after a surge of 33,000 fresh American troops there, war-weary U.S. voters probably will cheer President Barack Obama's speech Wednesday night announcing his timetable to start withdrawing troops from America's longest war.
But whether the drawdown helps or hurts Afghanistan — and ultimately what Americans think of how Obama handled it as he heads into his 2012 re-election contest — will depend on how fast troops come home and how quickly Afghans can step in to replace them.
"He has been working through his decision over the course of the last several weeks and finalized that decision today," White House spokesman Jay Carney said Tuesday.
The president will explain his timetable for withdrawal in a televised speech from the White House at 8 p.m. EDT. He'll travel Thursday to talk firsthand with troops at Fort Drum, N.Y., the home of the Army's 10th Mountain Division.
Obama, who decided in December 2009 to send an additional 33,000 troops to Afghanistan for a total of 100,000, said at the time that he'd start drawing down the surge in July 2011, and later that he'd pull all U.S. combat troops out by the end of 2014.
He's expected to announce Wednesday night the drawdown of 5,000 troops starting next month, and the full 33,000 by the end of next year. The remaining 67,000 troops would be drawn down over the following two years.
"The parameters of the decision involve the beginning of the drawdown of U.S. forces," Carney said Tuesday. "This is within a framework of the gradual transition of security lead to the Afghans. It's begun already in some places, but it will progress over the next several years."
At least 1,631 U.S. troops have been killed as part of the Afghanistan campaign since 2001, according to icasualties.org, which tracks casualties in the wars in Afghanistan and Iraq.
Obama's under growing political pressure to draw down the troops quickly, particularly since U.S. Navy SEALs killed terrorist mastermind Osama bin Laden on May 2 in Pakistan. Bin Laden's terrorist network and the Taliban regime that harbored it were the prime targets of the invasion of Afghanistan in 2001.
The number of Americans who want to withdraw troops as soon as possible jumped after the killing of bin Laden and is at an all-time high, the nonpartisan Pew Research Center reported Tuesday.
For the first time, a majority, 56 percent, want the troops brought home as soon as possible, while just 39 percent support keeping the troops there until the country is stabilized.
In Congress, Senate Armed Services Committee Chairman Carl Levin, D-Mich, argued Tuesday that a major troop reduction would accelerate Afghanistan's own hand in its security.
"A significant reduction in our troop level this year would send a critical signal to Afghan leaders that we mean it when we say our commitment is not open-ended and that they need to be urgently focused on preparing Afghan security forces to assume security responsibility for all of Afghanistan," said Levin, who wants at least 15,000 U.S. soldiers withdrawn this year.
Outgoing Secretary of Defense Robert Gates noted the pressure on Obama.
"The president has to take into account on any national security issue sustainability here at home, both among the public and in the Congress," Gates said at a news conference Tuesday. "And it goes without saying that there are a lot of reservations in the Congress about the war in Afghanistan."
Gates, however, is also among several senior U.S. officials who are concerned that a drawdown that's too rapid and extensive could allow the Taliban to recapture areas of their southern heartland that the U.S. surge pushed them out of.
Ali Jalali, Afghanistan's first post-Taliban interior minister, said Afghan forces "are not ready" to assume security in those parts of Kandahar and Helmand provinces.
Moreover, he said that the drawdown would reduce the chances that leaders of the Taliban and other insurgent groups would accept calls by the U.S., its allies and Afghan President Hamid Karzai to begin negotiating a political settlement of the war.
Pulling out U.S. forces too quickly — such as pledging to withdraw the 33,000 surge troops by the end of next year — could destabilize the country, said Robert Lamb, a senior fellow at the Center for Strategic and International Studies, a Washington research center.
"We do need to start withdrawing," he said. "My concern is that we do it at a rate that is constructive."
Withdrawing too quickly, he said, could throw Afghanistan's dependent economy into a depression and create an opening for new anti-American sentiment. It also would risk creating "a political vacuum that could be filled by any number of actors."
(Nancy A. Youssef contributed to this report.)
Obama's Afghan drawdown plan takes shape
Soldiers convicted in Afghan murders probe remain in the Army
Karzai confirms U.S.-Taliban talks as insurgents kill 9
For more McClatchy politics coverage visit Planet Washington