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RNA interference is getting the axe at major pharmaceutical companies. Is it too soon?
In February of 2008, the future looked bright for Arthur Krieg and a little technology known as RNA interference. Krieg had just joined Pfizer after the pharmaceutical giant acquired Coley Pharmaceuticals, a company he had cofounded in 1997 and where he had served as the chief scientific officer and executive vice president of research and development. Based on his extensive experience in developing oligodeoxynucleotides, Pfizer asked Krieg to head up a new division devoted solely to RNAi.
"I had to tell the group that we were being shut down. All the sites associated with our RNAi program were being closed, and all positions were being eliminated."
This biological phenomenon, which knocks down or dramatically lowers the protein output of selected genes by inserting a piece of double-stranded RNA into cells, was making leaps and bounds in the lab. Pfizer and many other big pharma companies saw this new technology as the wave of the future – a new way to target practically any gene that has a known sequence.
But this February – nearly three years to the day after he started his new position – Krieg stood in front of the 100-member group that Pfizer had hired to run its RNAi program to make a terrible announcement.
"I had to tell the group that we were being shut down. All the sites associated with our RNAi program were being closed, and all positions were being eliminated," he says.
What happened in those three intervening years? Whatever it was had also happened to other big pharma companies who invested in RNAi. Roche, Novartis, and Abbott Labs recently terminated their RNAi programs and severed their ties with biotech partners who were helping to develop the technology, sending shock waves through the field.
But while RNAi is getting the axe at big pharma, the technology has continued to march quietly forward at smaller biotech companies and academic labs. Animal studies recently have shown that RNAi could hold incredible promise for treating HIV, and human studies for cancers and other diseases are moving ahead into Phase 1 and 2 clinical trials. Could big pharma have pulled the plug before RNAi hit the big time?
RNAi still is an incredibly nascent technology. It only was discovered in the late 1990s, detailed for the first time in a seminal 1998 Nature paper by Andrew Fire and Craig Mello. There, the two scientists wrote about a strange phenomenon whereby double-stranded RNA injected into C. elegans had the power to potently silence genes. Since then, researchers have discovered that this concept also works for all living things – plants, insects and, eventually, humans.
The ability to silence any gene in the body would prove to be an incredible boon to research. No longer would scientists patiently have to wait a year or longer to make knockout mice to study gene function – with RNAi, the knockout could happen instantly. Additionally, trying to decipher the functions of genes essential to life wouldn't necessarily have to happen at the embryonic stage, before organisms bit the dust early on. Rather, researchers could knock these down later in life and see what happens.
RNAi therapeutics start acting when a short piece of double-stranded RNA (somewhere between 20 and 25 or so nucleotides) enters a cell. In the cytoplasm, the RNA bumps into an enzyme called dicer, which acts like a samurai sword-wielding ninja, chopping the dsRNA into smaller pieces known as small interfering RNAs. These siRNA unzip into two strands. One of the strands gets picked up by a group of different proteins known as the RNA-induced silencing complex. The entire package hunts down strands of messenger RNA inside a cell that complement the contained siRNA. Once that complementary strand is found, a group of enzymes chop up the matching mRNA. Without that mRNA, the corresponding protein can't get made. Since most diseases are the result of problematic proteins – either faulty construction of a necessary protein or too much of a good thing – ridding cells of certain proteins might lessen their consequences or, in the case of some infectious diseases, cure certain conditions altogether. Figure from Robinson, R. (2004) PLoS Biology 2, e28.
After Fire and Mello's influential paper, basic researchers flocked to RNAi. It was enough to win the two researchers the 2006 Nobel Prize in Physiology or Medicine, an unheard of turnaround in a novel field.
But years before Fire and Mello accepted their prize in Stockholm, RNAi also had caught the notice of pharmaceutical companies. The ability to silence specific genes, thereby ridding the body of pesky disease-causing proteins, also could provide unprecedented gains for therapies. Though about two-thirds of pharmaceutical targets currently are considered undruggable – with no small molecule currently identified or no way to specifically hit a target without causing other unspecific and undesirable effects – RNAi could provide a way to home in on a desired target through its gene sequence, making more targets druggable.
The problem, Krieg says, is that delivering double-stranded RNA has proven incredibly tricky. RNAs that are too long provoke an interferon response that muddies any effect of the RNAs themselves – a holdover from the earlier days of evolution when double-stranded RNA automatically equaled a viral attack. RNAs that are too short might not be enough to prompt sufficient interference. Naked RNAs are vulnerable to degrading RNAses circulating in blood and tissues. Finding a way to coat RNAs of the right size and sequence now has become a field in itself.
"People thought, 'Here we have this platform in which we're going to identify genes for breast cancer or chronic obstructive pulmonary disease or Alzheimer's, and then we'll have these RNAi compounds that we can give to patients, and they'll go where we want them to go and the patients will get better,'" Krieg says. "With more experience working with this, they realized that it's not going to work that way."
Delivery seems to have proven tricky for other big pharma companies as well, even those that are sticking with the technology. Over e-mail, Alan Sachs, the global head of exploratory and translational science at Merck, noted that the company had explored more than 300 different delivery technologies for a range of disease targets. But although Merck acquired RNAi biotech Sirna Therapeutics in 2006 for the astronomical sum of $1.15 billion, the company has yet to have any RNAi therapeutic candidates in clinical trials.
"Merck recognized from the outset that developing RNAi therapeutics would be a long-term investment and not a quick path to blockbuster drugs," he says, adding that the company "is taking a careful and steady approach to RNAi."
But the length of that investment – the time it would take to understand the best targets and develop the most effective delivery strategies – may have been more than the companies that dropped RNAi could bear. Though Krieg and his colleagues at Pfizer hoped to get an RNAi compound into the pipeline by this year and were making progress with their top candidate, a treatment for liver cancer, the team still had some distance to go by the time their program folded.
Krieg suspects that the story at Pfizer is the same elsewhere. As the company started to realize how much of an outlay RNAi would take to get to the clinic, it realized it probably wouldn't be able to recoup its investment. "The lifetime of patents by the time you get a drug approved is really insufficient to return the investment on a drug most of the time," he explains. "If you look at the pipeline, it's inadequate to support their infrastructure."
Roche, which also has invested heavily in RNAi therapeutics during the past few years, pouring hundreds of millions into its collaborations with biotech partners, issued a cagey statement about its own decision to leave RNAi behind. "The primary goal is to enable this important scientific work to continue outside of Roche and offer the best chance of success in providing benefits to patients," it said, adding that "Roche would consider the possibility of re-entering the field through external collaboration as clinical stage compounds emerge."
That re-entry might be just around the corner, says Barry Greene of Alnylam Pharmaceuticals, an RNAi therapeutics company that partnered with Roche until the company severed its agreement with Alnylam late last year.
Greene points out that Alnylam and other companies are rapidly moving ahead with their own RNAi therapeutics. At his company alone, several RNAi-based drugs already are moving through clinical trials. Alnylam even started its own initiative earlier this year named "Alnylam 5 x 15"—an effort to get five products in advanced clinical development by the year 2015. The most advanced therapeutic candidate in this program is a drug for transthyretin amyloidosis, an autosomal inherited disease that affects about 50,000 people worldwide and universally kills patients within five to 15 years of diagnosis. The drug currently is in Phase 2 clinical trials.
This disease, which attacks the liver, is an attractive target since the organ has a natural propensity to take up the nanolipid delivery vehicles created by Alnylam partner Tekmira that encapsulate the desired RNAi snippets.
Greene notes that Alnylam also has other RNAi-based drugs in clinical trials with the aid of pharmaceutical partners, including one for respiratory syncytial virus in Phase 2 and one for liver cancer in Phase 1. He hints that Roche and other companies soon will rue the day they decided to back out of RNAi research.
"I used to run the Boston Marathon every year, and this is like someone signing up and then quitting about 12 to 13 miles into the race," he says. Those companies that gave up too early, he adds, "aren't prepared to feel the thrill of the finish line."
Promising RNAi therapeutics research also is advancing in academic labs. In March of last year, John Rossi at the Beckman Research Institute of City of Hope published a paper in Science Translational Medicine showing that attaching an aptamer to a small piece of double-stranded RNA (known as a small interfering RNA or siRNA) could provide a dual way of attacking HIV. The aptamer itself showed the ability to neutralize free-floating HIV in infected mice, and when attached to the siRNA, it ferried the siRNA into HIV-infected cells. Results showed a significantly reduced viral load in the animals treated with the combination. Rossi says the team currently is experimenting with using different siRNAs to attack multiple HIV genes at once.
He adds that Dicerna Pharmaceuticals, the RNAi therapeutics company he co-founded in 2007 based on his findings that slightly longer siRNAs than those commonly used have a more potent knock-down effect, actually got a boost while other pharma companies were pulling back. Around the time Roche announced its own RNAi program termination, Japanese pharma company Kyowa Hakko Kirin forged a $1.4 billion agreement with Dicerna.
"We're really doing well at this point," says Rossi, who still serves as chair of the company's scientific advisory board.
In March of last year, chemical engineer Mark Davis of the California Institute of Technology published the results of a small Phase 1 trial of an RNAi drug targeting solid tumors aided by a nanoparticle delivery system. These encapsulated siRNAs were the right size, about 70 nanometers, to escape the leaky blood vessels that surround tumors, and they were tagged with transferin, a protein for which many cancer cells carry receptors on their surfaces. This combo allowed the siRNAs to specifically bombard tumors.
The trial showed that the therapy was safe, and biopsies from some of the volunteers' tumors showed the RNAi was doing its job – the targeted mRNA was cleaved at just the spot where the researchers would expect. Davis and his colleagues currently are testing the therapy in a larger trial, proof that they're not giving up anytime soon on RNAi.
"Despite what pharma says about RNAi, I think it's a really exciting area," he says. "I like to tell my students to work on something of high significance. It will be hard, of course, but I'd rather go down in flames working on something with high significance than something people don't really care about."
More from the current issue


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Mail Moments of Nostalgia and Networking
Left: Elena Heer (L), daughter of Guernsey, WY, Clerk Jane Heer and Guernsey Postmaster Curt Artery saddled up under the light of a full moon during a recent Pony Express ride reenactment. Right: Author Laura Vanderkam uses personalized stationery when keeping in touch with friends and contacts.
Get a behind the scenes peek of a Pony Express ride reenactment on this episode of Your Postal Podcast.
You'll also hear from the author of a recent Fast Company article on how to network with others.through the mail.
Click here to read a transcript of this podcast.
You can also listen to this podcast on your mobile device at YourPostalPodcast.com/mobile
Please send feedback and story ideas to email@example.com. Thanks for listening!

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"A great city should have great beer. New York finally has, thanks to Brooklyn. Steve Hindy and Tom Potter provided it. Beer School explains how they did it: their mistakes as well as their triumphs. Steve writes with a journalist′s skepticism as though he has forgotten that he is reporting on himself. Tom is even less forgiving he′s a banker, after all. The inside story reads at times like a cautionary tale, but it is an account of a great and welcome achievement."
Michael Jackson, The Beer Hunter®
"An accessible and insightful case study with terrific insight for aspiring entrepreneurs. And if that′s not enough, it is all about beer!"
Professor Murray Low, Executive Director, Lang Center for Entrepreneurship, Columbia Business School
"Great lessons on what every first–time entrepreneur will experience. Being down the block from the Brooklyn Brewery, I had firsthand witness to their positive impact on our community. I give Steve and Tom′s book an A++!"
Norm Brodsky, Senior Contributing Editor, Inc. magazine
"Beer School is a useful and entertaining book. In essence, this is the story of starting a beer business from scratch in New York City. The product is one readers can relate to, and the market is as tough as they get. What a fun challenge! The book can help not only those entrepreneurs who are starting a business but also those trying to grow one once it is established. Steve and Tom write with enthusiasm and insight about building their business. It is clear that they learned a lot along the way. Readers can learn from these lessons too."
Michael Preston, Adjunct Professor, Lang Center for Entrepreneurship, Columbia Business School, and coauthor, The Road to Success: How to Manage Growth
"Although we (thankfully!) never had to deal with the Mob, being held up at gunpoint, or having our beer and equipment ripped off, we definitely identified with the challenges faced in those early days of cobbling a brewery together. The revealing story Steve and Tom tell about two partners entering a business out of passion, in an industry they knew little about, being seriously undercapitalized, with an overly naive business plan, and their ultimate success, is an inspiring tale."
Ken Grossman, founder, Sierra Nevada Brewing Co.
Preface Steve and Tom Introduce the Brooklyn Brewery.
Chapter 1. Steve Tells How Choosing a Partner Is Like a Second Marriage.
Lesson One: Even a Dog Can Shake Hands.
Chapter 2. Steve Discusses the Importance of Building a Solid Team.
Lesson Two: Is It a Business or a Family Business?
Chapter 3. Tom Talks about Creating the Business Plan: A Money–Raising Tool and More.
Lesson Three: The Business Plan Won t Be Graded on a Curve.
Chapter 4. Tom Asks, What s the True Mission of the Business?
Lesson Four: Being Flexible If the Mission Statement Becomes Mission Impossible .
Chapter 5. Steve Discusses the Keys to Successfully Motivating Employees.
Lesson Five: Feeling Good Is No Substitute for Prudent Controls.
Chapter 6. Tom Tells the Story of Their Dot–Com Revolution: Fishing for Finance and Failing.
Lesson Six: Chasing Money Is Not a Business Strategy.
Chapter 7. Steve Talks about Building a Brewery in Brooklyn.
Lesson Seven: Sometimes You Stand Alone.
Chapter 8. Steve Discusses Publicity: The Press Wants You!
Lesson Eight: A News Release Can Go a Long Way.
Chapter 9. Steve Reveals How the Revolution Kills Its Leaders First.
Lesson Nine: Hiring and Firing.
Chapter 10. Tom Talks about Cashing Out and Reinventing the Business, Again.
Lesson Ten: Only You Will Know When It s Time to Sell.
Chapter 11. Tom Wants to Know If You Have What It Takes.
Lesson Eleven: There Are No Entrance Exams for Entrepreneurs.
Tom Potter


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Several US academics have argued in recent articles that the US should distance itself from Taiwan because China's power and influence are rising and it would become more "costly" for the US to maintain close ties with Taipei, and in particular maintain its defense obligations under the Taiwan Relations Act.
Charles Glaser of George Washington University argued along those lines in a recent article in Foreign Affairs, while Bob Sutter, also of GWU, recently painted an equally gloomy picture, saying that the rise of China is giving Beijing leverage over Taiwan, and in light of Taiwan's weakening positions in economic and military strength and the diplomatic front, the status quo is becoming unsustainable and Taiwan has very limited options for its future and unification with China is deemed inevitable.
The academics seem to make two assumptions: first, that the rise of China is unstoppable and the US needs to adjust its policy to accommodate Beijing's increasing influence on the international stage; and second, that given China's economic and military power, Chinese annexation of Taiwan is a foregone conclusion.
Neither of these assumptions takes account of the most important reason for US support for Taiwan — that Taiwan is a democracy and that China is still ruled by an authoritarian regime. If the US wants democracy to prevail in East Asia, it needs to be more assertive in its support for a democratic nation like Taiwan.
If the US wants China to become democratic, it needs to maintain a vibrant democracy on its doorstep. Right under the surface in China, people are clearly longing for a more free and open political system. Hundreds of human rights activists are languishing in prison, including Nobel Laureate Liu Xiaobo (劉曉波). In recent months, China has, in an effort to prevent anything similar to the revolutions spreading across the Arab world, intensified repressive measures and arrested and imprisoned more human rights activists, journalists, Internet bloggers and artists.
The basic conclusion is that China will not become democratic if the US gives up on Taiwan. However, the scenario of Taiwan's eventual unification with China is also totally out of step with the aspirations of Taiwanese. A recent opinion poll conducted by the Global Views survey center showed that nearly 70 percent of respondents rejected unification with China, and given a free choice, would opt for independence.
At this point, the people of Taiwan can still say what they want, in spite of China's military threat and intimidation. In less than eight months, on Jan. 14, Taiwanese are going to the polls to elect a new president.
The choice is clear: the Chinese Nationalist Party (KMT) government of President Ma Ying-jeou (馬英九) has maneuvered Taiwan into closer orbit with China, while the Democratic Progressive Party (DPP) wants to retain Taiwan's freedom and democracy, and — if elected — would steer the nation toward a more balanced policy, seeking closer cooperation with the US and other democracies like Japan.
Taiwan is at a critical juncture in its history. Recent opinion polls have shown that DPP presidential candidate Tsai Ing-wen (蔡英文), the first female presidential candidate in the history of Taiwan, is in a good position to win the presidency. In a recent Forbes article, she was described as a pathfinder and a creative thinker who has proposed practical and moderate approaches to dealing with China.


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Merck & Co, Inc.: Big Pharma Checkup for 2014
It's been tough sledding for Merck since it lost patent protection for its high profile $5 billion a year blockbuster drug Singulair in 2012. The lost sales have forced major restructuring that's included asset sales, lay-offs, and a laser focus on the company's pipeline.
However, Merck may be turning the corner. Investors thinking the worst may be behind the drug giant have helped lift shares in the past year.
The enthusiasm may not be misplaced.
Merck has a potential blockbuster cancer drug working its way through trials. MK-3475 is one of a new class of promising drugs, and it's currently in phase 3 clinical trials for advanced melanoma. Merck hopes to file for FDA approval this year.
Patients treated with MK-3475 saw a marked 81% improvement in overall survival and 41% of patients in the trial saw their tumor shrink.
If those results hold up and the drug gets the go-ahead from the FDA, it will compete against Bristol-Myers Squibb's successful cancer drug Yervoy, which is on pace to post more than $1 billion in sales.
The market for melanoma treatment is $2.4 billion in the United States and is expected to grow to as much as $4.5 billion by 2020 as new, more pricey treatments like MK-3475 win approval. Nearly 1 million people in the United States are diagnosed with melanoma, and nearly 77,000 new cases are diagnosed each year, according to the National Cancer Institute.
Cutting to the bone
Offsetting sales lost to patent expirations means, at least in the near-term, cutting down on costs. That includes plans announced in October to cut 20% of its workforce in a bid to shave $2.5 billion in expenses. Merck expects $1 billion of those savings will show up in 2014.
The company also sold its RNAi assets to Alnylam Pharmaceuticals this month, putting an end to investor uncertainty regarding patents that were acquired in a $1 billion purchase of Sirna Therapeutics in 2006.
As it struggled to monetize the acquisition, Merck shuttered Sirna in 2011. Investors my be unhappy with the $175 million sales price. However, despite Alnylam getting what may turn out to be a bargain, Merck does walk away with $25 million in cash, $150 million in Alnylam stock, more than $100 million in potential milestones, and the chance for royalties if Alnylam is able to commercialize any drugs using Sirna's patents.
Merck is also considering other big changes, including whether to jettison its consumer health care business. That business includes everything from Claritin to Coppertone sun protection and had sales of $443 million in Q3.
Rumors have popped up recently suggesting Merck may be discussing an asset swap with Novartis that would include Novartis taking over Merck's OTC portfolio in exchange for Novartis' animal health and vaccines product lines. Sales of Novartis' animal health business total roughly $1 billion a year and sales of Novartis vaccines reached $594 million in the third quarter.
But the changes have so far done little to encourage analysts who have cut their earnings outlook for Merck from $3.56 to $3.48 over the past 90 days. That drop-off is likely due to worries over the loss of patent protection for Merck's cancer drug Temodar, which had $900 million in sales last year.
Focusing investors on the areas for growth
During Merck's presentation at the recent JP Morgan Healthcare Conference in January, a lot of attention focused on growing areas of Merck's business, including vaccines, immunology, emerging markets, and diabetes.
The fastest growing of those four has been vaccines, with sales growing 15% year-to-date through September from 2012. That lift has come in large part thanks to higher sales of Gardasil, which produced revenue of $1.4 billion in the first three quarters of 2013, up from $1.2 billion a year ago.
Immunology has also been a strong performer, with sales up 12% during the same period thanks to Remicade. Remicade's sales totaled $1.6 billion in the first nine months of 2013, up from $1.5 billion in the comparable period of 2012.
MK-5172/MK-8742, a two drug combo treatment for hepatitis C that is in phase 2b, and MK-8931 in phase 3 trials for Alzheimer's disease potentially support future growth.
Fool-worthy final thoughts
Bristol charges $110,000 for Yervoy That suggests MK-3475, which Merck is studying in 10 trials across 10 different cancers, could be priced similarly. But Bristol isn't going to just hand over its market share for the indication. It's advancing its own PD-1 drug, nivolumab, through more than 25 studies too.
However, given Merck is trading at just 15 times forward earnings estimates -- below where shares have been valued over the past five years and less than Bristol's valuation -- there may be an opportunity in Merck for investors, particularly if the company can over-execute on its plans this year.
One more company that could make a big impact in 2014
There's a huge difference between a good stock, and a stock that can make you rich. The Motley Fool's chief investment officer has selected his No. 1 stock for 2014, and it's one of those stocks that could make you rich. You can find out which stock it is in the special free report: "The Motley Fool's Top Stock for 2014." Just click here to access the report and find out the name of this under-the-radar company.
The article Merck & Co, Inc.: Big Pharma Checkup for 2014 originally appeared on Fool.com.Todd Campbell has no position in any stocks mentioned. Todd owns E.B. Capital Markets, LLC. E.B. Capital's clients may or may not have positions in the companies mentioned. Todd also owns Gundalow Advisor's, LLC. Gundalow's clients do not have positions in the companies mentioned. The Motley Fool has no position in any of the stocks mentioned. Try any of our Foolish newsletter services free for 30 days. We Fools may not all hold the same opinions, but we all believe that considering a diverse range of insights makes us better investors. The Motley Fool has a disclosure policy.
Copyright © 1995 - 2014 The Motley Fool, LLC. All rights reserved. The Motley Fool has a disclosure policy.


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Cause Celeb highlights a celebrity's work on behalf of a specific cause. This week, we speak with music industry publicist and author Jo-Ann Geffen about her work with the Nancy Davis Foundation for Multiple Sclerosis as well as her experience co-editing the book "Chicken Soup for the Soul: The Story behind the Song." The foundation, founded by Nancy Davis in 1993 after she was diagnosed with multiple sclerosis, funds research to find a cure for MS. Its annual Race to Erase MS fundraising gala was held April 29.
Geffeninterviewed top songwriters about their inspiration and techniques for their songs. Part of the proceeds of the book will go to charities including the Nancy Davis Foundation for MS. In addition to being a writer, Geffen has worked as a Hollywood publicist, talent manager and celebrity booker, and currently heads JAG Entertainment.
Q: Tell me about the Nancy Davis Race to Erase MS.
Geffen: Nancy Davis' charity is very, very big because they focus on research. They get doctors and foundations from all over the world with the newest research, but also what she does that's extremely unique, or at least what her foundation does at her suggestion and demand, is they publish, not just positive results, but also negative results of studies which means that other doctors don't spend time and money doing the same thing to no avail. If it wasn't successful, why do it again?
Q: Is this information shared with everyone?
Geffen: Yes. Most organizations don't want to show failures, only success. They're afraid they won't get more money, or people will lose respect for them. But in fact, it's fabulous! That way, they can move forward, rather than laterally, which is foolish. Because of celebrity relationships that she's had, she's able to do the Race to Erase event every year which is huge, both in terms of raising funds, and in terms of awareness for the public.
More on charity and philanthropy
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- 2 NJ men admit 9/11 charity was a scam
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- Christmas tree built of toys will be donated to needy
- Boy becomes youngest to summit 22,000-foot peak
MS is really, really getting much more prevalent. I have a very, very dear friend who has it. Her brother just died from results of it; he had it very badly because he was in a facility since he was in his late 20s, which is unusual. Usually, it doesn't come on until late 40s. There are a lot of ancillary diseases you get. She was just diagnosed with Grave's disease. There a lot of things people don't know about, that are just being discovered, like a lot of the cosmetic applications that people use on their faces and stuff are not to be used with immune deficiency patients. They don't tell you that; the doctors don't do due diligence, that's how she got Grave's disease.
So there's a lot going on, in terms of research, in terms of information, in terms of due diligence that has to start being revealed. Nancy's organization really does spend money efficiently and effectively and gets results.
Q: How did you become involved?
Geffen: It was mainly because of her — she's a dear friend. I've known many people who have it or have had it. I've known agents who had to give up their business because they couldn't do it. People in licensing and merchandising. I have a male friend. I've learned a lot about it of late and a lot of it is environmental it seems. Some of it is dietary, or the dietary side of it can appease the symptoms. It can go into remission and out of remission.
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What's so difficult about finding a solution is that almost every case has unique symptoms; that's why it's hard to detect and it's hard to treat. It really is a challenge.
Q: What sets this organization apart from other MS charities?
Geffen: It's really the research aspect, and the disclosure.
Q: Tell me about your new book with Chicken Soup co-founders Jack Canfield and Mark Victor Hansen, "Chicken Soup for the Soul: The Story behind the Song," and how it related with your charity work, especially this organization.
Geffen: With this organization, we're giving some of the proceeds to them, because fortunately the Chicken Soup people are generous that way and they do give percentages of profit to charities. So it was my choice which charities and that's one of them. As far as the content, I've met a lot of the people in the book through one charity or another, from John Legend and Macy Gray to Kanye West with his foundation.
There are a lot of people fortunately are driven to either have their own foundation, people in entertainment that is, or to try to share and support charities they either have an affiliation with or respect for. Of course, there's several songs in the book in fact that relate to cancer. Melissa Manchester's "The Power of Ribbons," which has kind of become a theme. Melissa Etheridge in her song ("Message to Myself") relates to how she didn't know when she wrote it was pre-cancer, but after she was being treated for cancer, she wound up reading the lyrics back and listening to the music. There's a phrase in there about the "blackness in the chest", and she thought, "my god, this was prophetic, who knew that I would have a black junk taken out of my chest."
So there is reference in the book to various charitable causes and I hope people think well of it, makes them want to give back a little.
© 2013 NBCNews.com Reprints


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1. Roll With the Punches – Somewhat Accomplished
Handling adversity on the field was one of Arkansas' offensive weaknesses in 2013, but the Razorbacks dealt with the difficulties in a hostile environment more than usual in the season finale. For starters: LSU led 7-0, 14-7 and 21-20 on Friday. But each time, Brandon Allen and the Hogs maintained their composure and shrugged off the disappointment. The Razorbacks led 17-14 at halftime and 27-21 entering the fourth quarter. The only downfall came after LSU's go-ahead touchdown with 1:15 remaining. Arkansas still had time to move downfield, but Allen was sacked, stripped and the fumble was recovered by the Tigers to wrap up the win.
2. Third-Down Success – Not Accomplished
LSU was leading the nation in third-down conversions entering the game and had plenty of success against the Razorbacks in going 7-for-12. Some of the more frustrating moments came early on, when the Tigers converted on third-and-7 and third-and-10 on their opening touchdown drive. But it paled in comparison to LSU's last third-down conversion. Quarterback Anthony Jennings threw his 49-yard touchdown pass to receiver Travin Dural on 3rd-and-10 with 1:15 left in the game.
3. Win Turnover Battle — Not Accomplished
The Arkansas defense forced multiple turnovers for the third straight week. Braylon Mitchell's forced fumble in the first half led to a field goal that gave the Razorbacks a 17-14 lead. Alan Turner helped Arkansas add to it early in the second half with his interception off a tipped pass, setting up another field goal. But Arkansas' offense committed two turnovers as well. Allen threw an interception in the end zone for the second straight week. His fumble late in the fourth quarter ended the game. The Razorbacks finished minus-9 in turnover margin this season.
4. Positive Passing Plays — Accomplished
Arkansas may not have produced the biggest passing performance of the season, but it was one of the most efficient. Allen completed 19 of 29 passes (65.5 percent) for 178 yards with 2 touchdowns and an interception. The Razorbacks really enjoyed success with play-action passes, too, fooling LSU's defensive backs several times. The only big play was a 43-yard completion to receiver Keon Hatcher. It was the second straight week the Razorbacks had a completion over 40 yards. Allen also threw touchdown passes to Hunter Henry, who was wide open on both plays.
5. Sound on Special Teams — Accomplished
LSU has had a history of hurting Arkansas on special teams, collecting three returns for touchdowns under coach Les Miles. But the Tigers only had two opportunities to return kicks Saturday. Dangerous returner Odell Beckham Jr. had an 11-yard punt return before leaving the game with an injury. Jarvis Landry had no gain on his punt return. And place kicker Zach Hocker forced five touchbacks on kickoffs. Punt Sam Irwin-Hill had the special teams play of the game, too, pinning LSU at the one-yard line with 3:04 remaining. Unfortunately for Arkansas, the defense couldn't hold.
Quote Corner
• Coach Bret Bielema on Arkansas' senior class after a disappointing end:
"Our seniors, love them to death. They've been through a lot. Would've love to give them the Golden Boot (Friday), but for whatever life's reasons, it didn't want to happen. But I wish those guys nothing but the best of luck."
• Linebacker Braylon Mitchell on if this loss hurts more than Alabama blowout:
"This game hurts way worse than that, because we fought so hard, and to see the tears rolling down the seniors' faces and to not be able to bring the Boot back to Fayetteville for those guys, it hurts a lot. It was the last game of the season, but we approached it like it was a one-game season, and we were going to give it all we had for our seniors. It's definitely a lot tougher than the Alabama loss."
• Tight end Hunter Henry on Arkansas' competitiveness vs. LSU:
"We're not backing down from anyone. I'm just proud to be part of this team. We didn't back down one bit. But we should have won that game. I think we kept fighting throughout the year even when we were having consecutive losses. We just continued to fight."
• Quarterback Brandon Allen on his game-ending fumble:
"I should've thrown it away. Just tried scrambling to make a play. It wasn't really a deep pass. It was kind of like a concept we have, with a flat corner and a curl corner on the other side. I got flushed out of the pocket and was just looking for something to get open."
• Bielema on how to handle the difficult lessons learned at LSU:
"The only thing I asked them to do is take what you learned here and take it home with you. Don't leave it here. If we leave it here in Baton Rouge, we'll never overcome where we're at right now and I think our guys will."
Players of the Game
Offense – TE Hunter Henry (5 catches, 41 yards, 2 TDs)
The Razorbacks were able to get the ball to Henry more than the past few weeks and the results were important. While he didn't lead the team in receiver — Keon Hatcher had 7 catches for 84 yards — Henry got in the end zone twice. Both came on play-action plays near the goal line and the freshman was wide open each time.
Defense – S Alan Turner (11 tackles, interception)
Turner finishes the season the team's unlikely leading tackler, but did his job most of the season. It included Friday, when Turner led the team in tackles for the second straight week. He also grabbed his second interception in a three-game stretch to set up a field goal early in the third quarter. Turner finished the season with 97 tackles.
Special Teams – P Sam Irwin-Hill (Averaged 51.5 yards on 4 punts)
Irwin-Hill has been solid all season and saved one of his biggest moments for the season finale. The junior's 65-yard punt in the closing minutes was simply perfect, pinning LSU and its freshman quarterback at the one-yard line. Unfortunately, Arkansas' defense couldn't finish the job. The Tigers went on a 99-yard TD drive.
That Figures
6 — Number of bowl eligible teams in the SEC West this season after Mississippi State's overtime win in against in-state rival Ole Miss on Thursday. The Razorbacks are the only team from the division whose season ended this weekend.
14 — Number of freshmen that played in the finale. The list included six freshmen starters: Tight end Hunter Henry, guards Dan Skipper and Denver Kirkland, linebacker Brooks Ellis, cornerback D.J. Dean and defensive tackle Darius Philon.
20.7 — Arkansas' 12-game scoring average. It marked the program's lowest scoring average since 1997. The Razorbacks averaged 16.5 points during former coach Danny Ford's final season at Arkansas.
25 — Touchdown passes allowed by Arkansas in 2013, which is the most allowed in school history. It topped the 24 touchdown passes Arkansas allowed in 2012. The 25th allowed will be long remembered as well. Jennings' 49-yard strike to an open Travin Dural gave the Tigers their game-winning score with 1:15 remaining.
62.8 — Brandon Allen's completion percentage over the final three games (47 of 78). It helped raise the sophomore's to 49.6 percent (128 of 258) for the season. It was an improvement, but the Razorbacks still finished the season with its lowest team completion percentage (49.8 percent) since 2002 (49.5 percent).


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Video: The last Days of Project Lane Sarasota Florida – Snippet of Hood Kroniklz
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HERE there's a strict no-holds-barred-policy, where you have permission to forget the world outside and get lost —
IN the music, ON the dance floor, or WITH the taste of our award-winning BBQ.
HERE you'll become part of the show, not just part of the audience. Because HERE there's little distinction between dance floor and stage door.
We're one of those places where you're encouraged to dance the line, not walk it. HERE you're unleashed!


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I have fond memories of my time growing up and playing table-top role-playing games in the basements and garages of friends. Dungeons & Dragons may be our poison these days, but back in the day it was White Wolf all the way. The problem is: what if I want some elegance in my adult gaming? If I have more money than sense, what should I spend it on to make my gaming sessions as opulent as possible? Well, if you've actually had that thought, the Sultan Gaming Table has you covered.
The Sultan features "solid heirloom quality construction...premium quality hard rock sugar maple and black walnut hardwoods." There are three different playing surfaces, including an interior white board for your dungeons and miniatures, or a reversible table topper with felt on one side and either copper or wood on the other. The table also gives you four desks that fold out of the sides to hold all the materials for the players, including storage areas for all your source books, pencils, and character sheets.
My favorite touch: "two dice rolling trays, lined in your choice of velvet and capped with pointed rubber to ensure randomness of throws." Now that is hardcore. Also, there is a place for your Cheetos and soda.
How much will this wonder cost you? It's a steal at $9,650, delivered to your door. I'm not sure if this will ever be able to replace a card table with stale snacks and weak pot for the majority of role-players, but for those DMs with the means to make their games as enjoyable as possible, I can see the allure.
Okay, probably not, but the very existence of this thing is worth pointing out.


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The Official White House Tumblr sounds like a parody website that would be full of political snark and GIFs. But it's not a parody. The recently launched page is actually the official Tumblr for the White House. Like, for real.
But that doesn't mean there isn't snark and GIFs. This is Tumblr after all. Launched last week, it's part of the Obama administration's commitment to making this "the most open and accessible administration in history." Of course, the Tumblr also promises many pictures of Bo the White House dog because it knows where it's internet bread is buttered.
Check out some of the first photos and GIFs from the White House's foray into Web 2.0.


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Perfect In Case of Slips or Falls
Get Security and Protection for Yourself or Your Loved ones with our Medical Alert Systems.
Stay Safe in Your Own Home.
Don't Delay – Call Today for More Info!
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A medical alert system can provide many elderly and disabled individuals with the ability to live on their own, and exercise a high degree of independence. Here's what you need to know before signing up with a medical alert system provider.
Technically, an alert system is normally comprised of a wrist band transmitter " resembling a wrist watch " or a necklace-type transmitter that is worn at all times. If the individual should have a medical problem or accident, they can simply press a button on the worn transmitter to communicate with the medical alert monitoring center.
This helps the monitoring center specialist to better advise you in case of a medical emergency, and they may also send emergency medical help if required. Optionally, the monitoring center can be instructed to also contact one or more of your relatives whenever the help button is pressed.The price of a medical alert system can vary according to the level of service you require, but in general they are a very reasonably-priced alternative to assisted living centers.
Benefits of Medical Alert System in Babbitt Minnesota
The experts we consulted recommend looking for a medical alert system that meets all or most of these criteria.
It works for a user's specific disability. For example, a stroke survivor may need a device he or she can activate with one hand.
It offers a choice of a wristband and/or neck pendant. Cords worn around the neck can pose a strangulation risk; wristbands may irritate those with skin ailments.
It includes help buttons that can be wall-mounted near the floor in multiple rooms in case the user falls and isn't wearing the pendant.
It offers multiple choices for whom to contact if you need help, from emergency services to a friend or relative who lives nearby.
It has a battery backup in case of a power failure.
The base station can be contacted from anywhere on your property"even in your yard or at your mailbox.
The company has its own monitoring center, in the U.S., and employs its own trained emergency operators (rather than contracting that function out).
The monitoring center has been certified by Underwriters Laboratories (UL), a nonprofit safety and consulting company.
Babbitt Medical Alert System
Babbitt Medical Alert System
10 out of
10 with
66 reviews
Questions about the Personal Emergency Response System
Does the medical alert system come with other services? Some medical alert systems come with additional services such as medication reminders, glucose monitoring reminders, and the like. It's good to know what other services can be included with the purchase of your services, so make sure you ask what's included.
7. What happens if something goes wrong with my equipment? Most of us hate reading the fine print. I challenge anyone out there to read the "terms and conditions" of the 5 or 6 medical alert devices you want to evaluate (gives me a headache even thinking about doing that again). So that in mind, I would encourage anyone making a decision on a particular device to ask; What happens if your system goes down? Does someone come out to fix it? Will they send you another one asap? Do you need to send the dysfunctional system back? etc. Also, one other point… when you have narrowed down your choice, read the fine print by looking up the terms-and-conditions of the particular provider on their websites.
8. Does the medical alert system include "automatic fall detection"? Medical alert systems have come a long way in the last 5 years. Today's advanced systems can detect when a user has fallen automatically. It's all in the advanced algorithms developed by brilliant engineers and embedded into small devices which are saving lives everyday. These smart-systems can distinguish (in most cases) between when someone has actually fallen, and when someone has decided to sit down abruptly. "The big three" that (currently) offer automatic fall detection are Halo Monitoring Systems, Wellcore Personal Emergency Response, and Philips Lifeline with auto alert.
9. Am I purchasing these devices, or leasing them, or neither? Goes back to my prior suggestion about reading the fine print… Find out (ahead of time) whether the equipment is yours or not. What happens if you no longer require the equipment? What happens if you damage the equipment?
10. What is my total yearly cost? This gets down to "brass tax"… How much does this cost me each year (total cash outflow). Enough said.
Nearest Medical System to You In Saint Louis County 55706
How to pick the right one in MN
One can compare medical alert systems on the basis of value, cost-effectiveness and quality. Purchase price, monthly fee, and alert neighbor facility are some of the features that can be taken into consideration.
It is a common practice for companies to compare their medical alert systems with those produced by other companies. Besides, companies provide comparison of their own products. Some of these alert systems come with warranty whereas some do not have one. Many of these products are endorsed by major medical foundations.
Some medical alert systems are specifically designed to cater to seniors living alone or left alone frequently, while others cater to both elderly people and those with certain medical conditions. Emergency medical response systems for babysitters and woodworkers are among the alert systems with maximum utility value. Watch type systems hide their alert buttons under the face of a water-resistant, fully-functional wristwatch. Some other alert systems resemble jewelry and can be worn on the wrist or around the neck. Yet others can be mounted on the wall for convenient access.
While most medical alert systems have console units, some alert systems have no console unit. One of the best examples for an alert system without console is the cell phone type alert system, which directly sends messages to the monitoring center. The alert systems with console unit work indoors or outdoors up to 100 feet from the console unit. Wireless alert systems have adjustable infrared sensors that transmit signals up to 1200 feet, and detect motion up to 30 feet away. Some medical alert systems inform the subscriber during dialing, shutdown, system test, and battery test.
To compare medical alert systems on the basis of battery life, the working time ranges from 18 to 24 hours without any power supply. Motion detector and fall sensor are additional equipments available with most medical alert devices.
How a Medical Alert System helps you?
Do your aging parents need a home medical alert system?
Part of the aging process includes increased frailty, and increased chance of accidents. All it takes is one fall for an elderly person to end up with months of hospitalizations, medical bills, rehabilitation, and more. In addition, the elderly are more likely to have medical issues that may require immediate attention. And there are, of course, a host of other problems that can come up as well, from a furnace going out in the middle of winter, to a tree falling due to a thunderstorm. They may need help, and not be able to reach a phone. Whatever the reason, it is easy to see why your aging parents need to be able to contact help quickly if needed; the kind of help that home medical alert systems can provide.
Choose a home medical alert system that is right for your senior
Trying to sort through the hundreds of home medical alert systems can be overwhelming and confusing. Careful research of all of the features of the systems being considered is an important first step in choosing the best one for your aging parents. The best way to start is by learning how these systems are designed to work.
You will find that most home medical alert systems fall into two different categories: those that come with 24/7 monitoring services, and those that provide equipment only, but no service.
Home medical alert systems with monitoring service
Home medical alert systems that provide a monitoring service will usually include a service agreement between the customer and the monitoring company. These types of systems work like this: if the alert device is activated, the monitoring system is notified, and they in turn, contact the designated people and/or emergency personnel.
An important consideration when choosing a system with monitoring is that they are typically more expensive than products without. There will be a monthly fee charged for this service, which can be in the range of $30-40 per month, in addition to an installation or activation fee.


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WASHINGTON, Nov. 21 (UPI) -- Dierks Bentley, Alison Krauss, Kris Kristofferson and Lyle Lovett performed at the White House Monday as President Barack Obama celebrated country music.
At the seventh event in the "In Performance at the White House" series, the president said he and first lady Michelle Obama were "transforming the East Room into a bona fide country music hall."
"As Charley Pride, who played here two years ago, once said: 'There is enough room in country music for everybody,'" he said.
The lineup of performers Monday also included James Taylor and The Band Perry.
Kristofferson, Lovett and singer Darius Rucker joined the first lady Monday afternoon in conducting a workshop on the history of country music for young musicians.
"It is a proud history that runs from barn stomping to the great honky tonks to the big stage to the GRAMMYs," the president said. "It's a unique history that ties together many threads of our immigrant heritage -- like the Irish fiddle, the German dulcimer, the Italian mandolin, the Spanish guitar and the West African banjo -- into music that is truly Made in America. And at its most pure, that's what country music is all about -- life in America."
Previous "In Performance at the White House" events celebrated jazz, classical, Broadway, R&B and Latin music.
Monday's performance was streamed live on the White House Web site and is scheduled to be televised on PBS stations Wednesday.


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The BENCHMARQ bq2057 series advanced Lithium-Ion (Li-Ion) and Lithium-Polymer (Li-Pol) linear charge-management ICs are designed for cost-sensitive and compact portable electronics. They combine high-accuracy current and voltage regulation, battery conditioning, temperature monitoring, charge termination, charge-status indication, and AutoComp charge-rate compensation in a single 8-pin IC. MSOP, TSSOP, and SOIC package options are offered to fit a wide range of end applications.
The bq2057 continuously measures battery temperature using an external thermistor. For safety, the bq2057 inhibits charge until the battery temperature is within user-defined thresholds. The bq2057 then charges the battery in three phases: conditioning, constant current, and constant voltage. If the battery voltage is below the low-voltage threshold, V(min), the bq2057 precharges using a low current to condition the battery. The conditioning charge rate is approximately 10% of the regulation current. The conditioning current also minimizes heat dissipation in the external pass-element during the initial stage of the charge. After conditioning, the bq2057 applies a constant current to the battery. An external sense-resistor sets the current. The sense-resistor can be on either the high or low side of the battery without additional components. The constant-current phase continues until the battery reaches the charge-regulation voltage.
The bq2057 then begins the constant-voltage phase. The accuracy of the voltage regulation is better than ±1% over the operating-temperature and supply-voltage ranges. For single and dual cells, the bq2057 is offered in four fixed-voltage versions: 4.1 V, 4.2 V, 8.2 V, and 8.4 V. Charge stops when the current tapers to the charge termination threshold, I(TERM). The bq2057 automatically restarts the charge if the battery voltage falls below the V(RCH) threshold.
The designer also may use the AutoComp feature to reduce charging time. This proprietary technique allows safe and dynamic compensation for the internal impedance of the battery pack during charge.
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On the Prowl for a Stylish New Tundra, Tacoma, RAV4, Camry or Highlander to Cruise Around the Streets of Nampa?
You've come to the right place: Edmark Toyota, Serving Boise, Meridian and Caldwell has just the thing-- a Vehicle from our Toyota Lineup.
At our dealership in Nampa, Idaho, we are not only interested in your dream car but committed to finding it for you. Between our new models, like the Tundra, Tacoma, RAV4, Camry and Highlander, or our like-new used auto inventory, we're confident that your four-wheeled match is here at Edmark Toyota.
Edmark Toyota's Care Doesn't Stop There: Our Helping Hand Reaches Farther to Elevate Your Driving Experience to the Next Level
Even after you leave our showroom in your new Tundra, Tacoma, RAV4, Camry or Highlander, there are still many ways that we at Edmark Toyota can help make your driving experience the best it can be. Our knowledgeable auto repair and service team are conveniently located at our dealership in Nampa, Idaho, so all of the drivers we serve from Boise, Meridian and Caldwell can pop in for routine upkeep or an unexpected quick fix. Yes, we make buying and maintaining a Toyota vehicle easy, so you can spend more time having fun in it!


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More than two dozen newly released court documents reveal details in the death of Brittany Killgore, who officials say was an unwilling participant in a deadly sex game.
The 22 warrants obtained by NBC 7 San Diego detail the sadomasochistic lifestyle of the three people facing murder and torture charges in Killgore's death. The documents were formerly sealed at the request of the San Diego County District Attorney.
The Fallbrook woman's body was found at Borel Road and Arosa Street in Winchester, California near Lake Skinner four days after she was reported missing in April 2012.
Dorothy Grace Marie Maraglino, 36; Jessica Lynn Lopez, 25 and U.S. Marine Staff Sgt. Louis Perez, 45, have pleaded not guilty to murder charges in the killing of the 22-year-old Marine wife.
Last week an amended complaint was filed, adding new allegations to the murder charges, our media partners the North County Times reported.
The complaint also accuses the three suspects of conspiring to kidnap, torture and sexually assault Killgore.
When investigators searched a home on East Fallbrook Street, the residence of Maraglino and her roommate Lopez, they say they found a room in the home that was set up to be an apparent sex dungeon.
The warrants list items removed from Maraglino's home include a plastic and wooden whips and crops, leather restraints, ball gag, leather collar, zip ties, various ropes and cords, swords, a machete, black spiked gloves and a black knife labeled "The Black Defender."
They also removed several video cameras and computers found in the home's basement, computer hard drives and personal journals. Detectives recorded a number of video tapes were found in the search including several VHS tapes inside a bag in the trunk of Perez' vehicle. However the documents don't reveal what, if anything, was recorded on those video tapes.
Killgore had injuries to her neck that "were consistent with her being strangled" and injuries and her wrist and leg that were "consistent with someone using a tool such as a saw [sic] an attempt at dismembering her," the court documents state.
In a suicide note found at the time of Lopez' arrest, the suspect had documented how she tried to dispose of Killgore's body like Dexter, the serial killer character on a popular cable television show.
Detectives state in the documents that the defendants practiced a sadomasochistic lifestyle. Maraglino identified herself as a dominatrix and Perez admitted he liked to spank women officials said in the warrants.
The defendants told investigators they were involved in sexual activities which included master, servant and slave role playing the documents state.
Homicide investigators, faced with the disappearance of Killgore on April 13, quickly requested access to mobile phone and cell tower records from various carriers as well as email passwords and titles of cable movies rented via on demand.
Click here for a timeline of events in the Brittany Killgore murder case
In four search warrants unsealed in July, investigators say they found evidence that an SUV owned by Perez had been used to dump Killgore's body in Lake Skinner.
Also, a shopping bag containing blue latex gloves and a stun baton was also found during the investigation according to the warrants. Both the bag and the gloves had a red substance on them that tested positive for blood the documents show.
In the warrants, investigators say that San Diego County Crime Lab technicians confirmed the blood to be "a match for the DNA profile of Brittany Killgore."
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I am using Ubuntu 10.04 LTS, dual boot with Windows 7 on ThinkPad T400, I followed Ubuntu update hints and installed some update for my ATI Radeon graphic card, but when I boot to Ubuntu (means I can still load GRUB), the screen goes to blank and no matter what key stroke, I can not get any responds. I can't even open a terminal.
However when I hit the power button, the computer would pop out the Ubuntu shutdown screen briefly and shut down.
I figure out I should delete the updates package for my graphic card, but I don't even get a chance to go to text terminal, please help me!


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BEIJING, June 24, 2014 (GLOBE NEWSWIRE) -- ChinaCache International Holdings Ltd. ("ChinaCache" or the "Company") (Nasdaq:CCIH), the leading total solutions provider of Internet content and application delivery services in China, today announced that it will participate in the Sinolink Securities Strategic Investment Conference on Friday, June 27, 2014 at the Marriott Hotel in Ningbo, China. Investors who wish to meet with ChinaCache representatives may contact ChinaCache directly at email@example.com or Glenn Garmont through email@example.com. About ChinaCache ChinaCache International Holdings Ltd. (Nasdaq:CCIH) is the leading total solutions provider of Internet content and application delivery services in China. As a carrier-neutral service provider, ChinaCache's network in China is interconnected with networks operated by all telecom carriers, major non-carriers and local Internet service providers. With more than a decade of experience in developing solutions tailored to China's complex Internet infrastructure, ChinaCache is a partner of choice for businesses, government agencies and other enterprises to enhance the reliability and scalability of online services and applications and improve end-user experience. For more information on ChinaCache, please visit en.chinacache.com. Safe Harbor Statement This announcement contains forward-looking statements. These statements are made under the "safe harbor" provisions of the U.S. Private Securities Litigation Reform Act of 1995. These forward-looking statements can be identified by terminology such as "will," "expects," "anticipates," "future," "intends," "plans," "believes," "estimates" and similar statements. ChinaCache may also make written or oral forward-looking statements in its reports filed or furnished to the U.S. Securities and Exchange Commission, in its annual reports to shareholders, in press releases and other written materials and in oral statements made by its officers, directors or employees to third parties. Statements that are not historical facts, including statements about ChinaCache's beliefs and expectations, are forward-looking statements. Forward-looking statements involve inherent risks and uncertainties. A number of factors could cause actual results to differ materially from those contained in any forward-looking statements, including but not limited to the following: the Company's goals and strategies, expansion plans, the expected growth of the content and application delivery services market, the Company's expectations regarding keeping and strengthening our relationships with its customers, and the general economic and business conditions in the regions where the Company provides its solutions and services. Further information regarding these and other risks is included in the Company's filings with the U.S. Securities and Exchange Commission. All information provided in this press release is as of the date of this press release, and ChinaCache undertakes no duty to update such information, except as required under applicable law.
CONTACT: ChinaCache Investor Relations Contacts: Mr. David She Vice President of Finance ChinaCache International Holdings Tel: +86 (10) 6408 5307 Email: firstname.lastname@example.com Mr. Don Markley or Mr. Glenn Garmont The Piacente Group | Investor Relations Tel: +1 212-481-2050 Email: firstname.lastname@example.com


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Two-way PowerG Wireless Portable Keypad - KP-140 PG2
KP-140 PG2 is a portable, wireless, two-way keypad for PowerMaster(R) residential alarm systems. It enables easy arming and disarming of the alarm system and initiation of emergency, fire and panic alarms. KP-140 PG2 also controls programmable outputs (PGM) and X-10 devices from anywhere in the home or office. Two-way communication with the control panel provides homeowners with visual indication of successful command execution and system status.
KP-140 PG2 can be installed as a fixed wall-mount device or as a portable application. When wall-mounted, it provides back-tamper protection and supervision alerts.
Based on Visonic's ground-breaking PowerG technology, KP-140 PG2 combines several field-proven advanced technologies and the highly reliable AES encryption method. This combination of technologies delivers an extended transmission range and battery life, and unmatched advantages for professional installers, central monitoring stations and end-users alike.
- Designed for arming, disarming, emergency signaling, home automation and remote control applications
- Typical indoor range: 50-100m
- Indicates entry and exit periods even when not touched by a user
- Back light illumination
- Visual indications for system status, troubles and memory
- Wall-mount bracket
- PowerG, two-way Frequency Hopping Spread Spectrum FHSS-TDMA technology - provides robustness and reliability closer than ever to wired
- Employs the proven AES-128 (128 bit key) advanced encryption algorithm for correct message identification and to protect the alarm system against code grabbing and other attacks
- Continuously measures communication quality and automatically sets transmission power to the minimum required for reliable communication
- Tamper detection
- Longer battery life (up to 5 years with typical use)
Additional Info
Additional Info
|Part Number
|What's in the box
|(1) Visonic PowerMaster PowerG Wireless 2-Way Keypad
Write Your Own Review
|Battery type
|3V, CR123A Lithium Battery
|Weight (including battery)
|107g (3.4oz)
|Operating temperature
|0°C to 49°C (32°F to 120°F).
|Operating environment
|127 x 70 x2 4mm (5 x 2.75 x 1in)


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Console Xray Slider Page1
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Use the form on the right to contact us.
You can edit the text in this area, and change where the contact form on the right submits to, by entering edit mode using the modes on the bottom right.
Jerikovn. 16
Oslo, 1067
This is the Datamatik SCADA online store. Datamatik acts as a distributor and project integrator for Motorola Radio and SCADA products.
The company specializes in Remote Control Operations, Supervisory Data transfer, Mototrbo Tetra digital telemetry transfer.


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Learn & Support
Having trouble registering or activating your product? Click the "CHAT NOW" or "NEED HELP" button on the right side of the page for assistance.
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Good Life
California solar company makes its way without subsidies
After laying off 40 percent of its local staff and phasing out a once promising line of business, Roseville's Solar Power Inc. did the unthinkable last year: It returned nearly $25 million in federal stimulus funding.
The solar industry has come under intense scrutiny in recent weeks with the collapse of Solyndra, the Fremont manufacturer that received $535 million in federal loan guarantees.
But for every Solyndra, there are scores of companies like Solar Power Inc. that have gotten by without federal funding. They provide a counterpoint to the growing criticism that the solar industry requires heavy subsidies.
"Solyndra has given the industry a black eye," said Solar Power CEO Stephen Kircher.
"I think it's huge disservice to the solar industry that the public now thinks that solar is too expensive, isn't going to work, that it's black magic."
As Solyndra's bankruptcy filing indicates, the nation's solar industry is facing a huge shakeout. Plummeting prices for solar panels, low-cost competition from China, huge upfront costs for consumers and a lack of funding for large-scale projects are just some of the barriers to the industry's growth.
Kircher sat down with The Bee last week at the company's new headquarters in Roseville's Johnson Ranch community for a wide-ranging interview about the solar industry and recent developments at the company.
Solar Power – which is in the middle of changing its name to SPI Solar – was founded in 2005 and is best known for high-profile projects such as a rooftop installation at Staples Center in Los Angeles and a solar farm at Aerojet in Folsom.
But like many companies in the renewable energy sector, Solar Power has struggled, losing money in each of the last four years.
The company's stock has gone from a high of about $4.50 in October 2007 to a low of 18 cents last October. It's now trading around 30 cents per share.
"We've proven in the past that we have good developers and good sales people," Kircher said. "What we've been unable to do is make money with that."
That's about to change thanks to Solar Power's new partnership with LDK Solar Inc.
To read the complete article, visit www.sacbee.com.


text: Dave's ESL Cafe's Student Discussion Forums :: View topic - What do yo think about a "jury system"? Dave's ESL Cafe's Student Discussion Forums"The Internet's Meeting Place for ESL/EFL Students and Teachers from Around the World!" FAQ Search Memberlist Usergroups Register Profile Log in to check your private messages Log in What do yo think about a "jury system"? Dave's ESL Cafe's Student Discussion Forums Forum Index -> Current News View previous topic :: View next topic Author Message naoooomis21Joined: 11 May 2009Posts: 1Location: Japan Posted: Mon May 18, 2009 6:51 pm Post subject: What do yo think about a "jury system"? By May 2009, Japan will introduce a new jury system, for the first time in Japan's history, in which ordinary citizens will take part in criminal proceedings as judge to help decide the outcomes of trials. A group of six citizen judges along with 3 professional judges will give judgment on a criminal case. There are several opinions to it. About 50 percent of people say that they dont want to join in it, if it is possible. A problem is that whether people who are not familiar with the law really can judge a man. In my opinion, I dont want to join in it because Im afraid of deciding ones life. What do you think about this? Do you think the system make Japan better? Back to top weiyaoJoined: 20 Jun 2005Posts: 105 Posted: Fri May 22, 2009 11:47 pm Post subject: In the U.S, we have a similar jury system. Once in a while, we receive a juror summon. Upon receiving this summon, we need to go to the court to serve as a juror. Back to top Display posts from previous: All Posts1 Day7 Days2 Weeks1 Month3 Months6 Months1 Year Oldest FirstNewest First Dave's ESL Cafe's Student Discussion Forums Forum Index -> Current News All times are GMT - 8 Hours Page 1 of 1 Jump to: Select a forum Student Forums----------------ComputersCurrent NewsCultureEnglish SchoolsFamilyFilm and CinemaFoodHealth and FitnessHelp CenterHobbiesHolidaysLearning EnglishLiteratureMaking FriendsMusicOpinionsPetsScienceSportsThe Strange and MysteriousTOEFL and Other English ExamsTravel You cannot post new topics in this forumYou cannot reply to topics in this forumYou cannot edit your posts in this forumYou cannot delete your posts in this forumYou cannot vote in polls in this forum Dave's ESL Cafe is maintained by the one and only Dave Sperling. Banner Advertising | Bookstore / Alta Books | FAQs | Articles | Interview with Dave Copyright © 2018 Dave's ESL Cafe | All Rights Reserved | Contact Dave's ESL Cafe | Site Map Teachers College, Columbia University: Train to Teach English Here or Abroad Powered by phpBB © 2001, 2002 phpBB Group


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I learned that a long walk and calm conversation are an incredible combination if you want to build a bridge.
Local Area
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Crowne Plaza Al Khobar sits at the entrance to Al Khobar on King Abdullah Road, the main expressway to Jubail, Dammam, Hofuf and the capital Riyadh, 3 hours away. King Fahd International Airport is 35 minutes away. We are a short stroll or drive from nearby businesses and vast shopping malls Al Rashed and Al Dhahran malls, while the picturesque Corniche fringing the azure waters of the Arabian Gulf is within 5 minutes.
You'll find the peaceful Palm Court Lounge in the atrium between our tempting Al Morjan meeting room and Marrakesh Moroccan restaurant. Network over cocktails around the dramatic glass pyramid centrepiece that changes colour. Primavera is the place to marvel at sumptuous themed buffets, chocolate fountains and live cooking stations where chefs make fresh naan bread.
Host a workshop or reception for 8-80 people in 9 meeting rooms and our Crowne Plaza Meetings Manager will arrange all the details. Throughout Crowne Plaza Al Khobar, we take care of your needs.
Rooftop Health Club and Spa with Indoor Pool, Sauna, Jacuzzi, Steam Rooms, Massage, and Gym features latest fitness & body-building machines. After a good workout, Oasis juice bar is a perfect place to relax.


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[Ahavath Sholom Minutes]
Description: Handwritten list of the thirty one members of the Ahavath Sholom Congregation in 1895 in Fort Worth, Texas. The front of the document lists the members of the congregation, and the back of the document lists the officers. When the list was created, Ahavath Sholom was the only synagogue in Fort Worth.
Date: October 6, 1895
Creator: Levenson, Ben
Item Type: Refine your search to only Text
Partner: Fort Worth Jewish Archives


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| September 28, 2010, 11:04 am
Boulder photographer James Balag has won the 2010 Heinz Award for the Extreme Ice Survey, his vanguard, time-lapse documentation of the rapid depletion of ancient glaciers around the world in 2005-06.
"With groundbreaking photographs, James Balog documented how dramatically global warming is transforming our planet," Teresa Heinz, chairman of the Heinz Family Foundation, said in a press statement. "Mr. Balog worked in treacherous conditions to capture evidence that people otherwise wouldn't see."


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October 18, 2012-Completing a Project List
Taking a break from boat projects and going sailing last Sunday seemed like a good idea.
The "Fun Race" scheduled for that day, which consisted of a noon start and three laps around an island, held little appeal for us. Instead we waited until late afternoon and then, when the day had cooled off a little, and went out for a nice sunset sail with a bunch of friends on board. Anchoring afterwards in Scotland Bay we watched the full moon rise and cooked burgers and boerewors on the grill. We didn't stay out late however; by 21:00 everyone was ready to motor back to their own boats get tucked into their own snug bunks.
wingssail images-fredrick roswold
Cabin Full Of Guests.
This week we completed our canvas project by sewing the new dodger, a large awning and rain catcher, and a small sailing awning. With this we have reached the bottom of a long list of significant refit projects which started in Thailand three years ago and against which we have been steadily chipping as we worked our way around the world from Asia to the Caribbean.
wingssail images-fredrick roswold
New Canvas.
We've now completed exterior refinish including new Awlgrip topsides, deck paint, hatches, repainting and rebuilding of all the spars, and of course finished the canvas. We've redone the interior including new upholstery, cabin sole refinish, bulkhead painting and total re-varnishing. We completed major structure renewals including rudder, rudder tube, stern tube, keel bolts, mast step, and chain plates. We've done major engine work, replaced the dingy, life raft, solar panels, autopilot, and rebuilt the windvane. We've rebuilt much of the sailing instrumentation and wiring, bought new computers and navigation computers, installed AIS, bought batteries, alternator, radio and tuner, inverter/charger, watermaker membrane, hot water heater, and propane system, and purchased LED interior and exterior lighting. We completed a stove rebuild (twice), installed new fixtures, and bought new running rigging and sails.
And we've sailed 15,000 miles. We've done a refit on the go; so to speak.
Of course the boat list never ends, new items are constantly being added, so we'll be able to keep busy. But perhaps, for the next year or so, we can focus on the small items which come up from time to time, before going back to the beginning of the major project list and starting over.
So now the days take on a familiar cadence. We swim in the mornings for exercise, find some way to be productive on the boat, interact with the other cruisers here in Trinidad, and we think about our next move. In November we will head out to explore the rest of the Caribbean. We don't know exactly where we'll go nor what we will have to fix along the way, but we'll find interesting new places to explore and, for sure, we'll be fixing something.
That part never ends.
Fred & Judy, SV Wings, Trinidad
Click here for more photos of the sunset sailing trip.
Click here for more shots of the new canvas.
Click here for a sampling of photos of all the projects on this big list.


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Venturing Bronze Award
From MeritBadgeDotOrg
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[[Image:.jpg|thumb|Venturing Bronze Award. Bronze Award metal is pinned immediately above the seam of the left pocket; the ribbon devices are worn above the left pocket in a rack above any knots. 1.Bronze Award metal shown with Sports, Religious and Community Life, Arts and Hobbies, Outdoor, and Sea Scout miniature device pins. 2. The Bronze Award ribbon devices for daily uniform wear: a. Sports, b. Religious and Community Life, c. Arts and Hobbies, d. Outdoor, e. Sea Scout.]]
There are five bronze awards available to Venturers:
There are five bronze awards available to Venturers:
Revision as of 14:36, April 24, 2007
There are five bronze awards available to Venturers:
- Sports Bronze Award
- Religious and Community Life Bronze Award
- Arts and Hobbies Bronze Award
- Outdoor Bronze Award
- Sea Scout Bronze Award
Upon completion of a bronze award, a metal is awarded with a miniature device that pins to the metal and a bar that is worn above the left pocket of the uniform for daily wear.
One bronze award is a prerequisite to earning the Venturing Gold Award and the Venturing Silver Award.
In addition, the Sports Bronze Award requirements are part of the Quest Award, as is the Religious and Community Life Bronze Award part of the TRUST Award, the Outdoor Bronze Award part of the Ranger Award, and the Sea Scout Bronze Award necessary for the Quartermaster Award.
Venturers may earn one or all five Venturing Bronze Awards.


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Journalism from around the world: Television and #radio via @StirringTrouble @JamesDelingpole @AlJazeera
Another highly entertaining discussion about this weeks news. VoR's Brendan Cole is joined by James Delingpole of breitbart.com and Alexander Nekrassov for half an hour of incisive mulling over the week's headlines. A light hearted look at current affairs and political news from within the United Kingdom.
Telling It Like It Is's insight:
Implosion of the LibDems,Ukrainian elections,US troops to remain in Afghanistan, Gove 'banning' classic US literature in UK schools and One Direction allegedly smoking something, saying the 'N-word'.
Vesti news is a local mainstream television broadcasting station in Russia. On the show is a collection of speakers talking about Normandy. Various thoughts are shared about what happened all those years ago. Each of the experts share how they remember the troops lost and the historical victorious events that came from the troops bravery.
Vesti's insight:
Alexander Nekrassov speaks to the panel in Russia over on Vesti News. This video interview is in Russian and can be viewed on most devices.
In the 21st century, it is time to opt for orderly regime changes versus violent revolutions and uprisings. Another interesting read over on AlJazeera made earlier this week.
Al Jazeera's
Re-blogged from an article over on AlJazeera Viktor Yanukovich, Alexander Nekrassov, Ukraine, Russia, United States, UN Security Council all on AlJazeera.
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In terms of technique, Darren Aronofsky's Black Swan is arguably a masterpiece. The way Aronofsky manipulates sight, sound and editing to create this story of ambition and madness, shows that he is truly one those increasingly-rare directors who is worthy of the title "filmmaker," as oppossed to "glorified video game and/or music video maker."
So why am I not yet ready to tout Black Swan as "the film of the year?" Because for all its technical marvel - and wonderful performances - the movie falls short of its primary goal: conveying a moving and/or interesting story.
Nina Sayers (Natalie Portman) has been a dedicated little ballerina all her life, but even though she belongs to a prestigious New York ballet company, she's never really had her opportunity to shine in the limelight, center stage. That all changes when the director of the company, Thomas (Vincent Cassel), decides that his former star and "little princess," Beth (Winona Ryder), no longer has the necessary magic to light up the stage. Thomas has a new and edgy interpretation of "Swan Lake" planned and he needs a Swan Queen who can embody both the light and dark aspects of the soul. He knows Nina has what it takes to embody the light side, but the quiet, timid, girl lacks that dark edge of a true Black Swan.
Enter Lily (Mila Kunis), a dancer who is wild and passionate where Nina is disciplined and almost robotically precise. Lily quickly catches Thomas' attention and as she and Nina get closer, Nina begins fear that her position as queen is in danger of being usurped.
While this might sound like the plot of a good thriller, in truth, Black Swan only borrows select parts from that genre, while it also attempts to stitch a patchwork together from a strange mix of other genres, including Film Noir and late 70s/early 80s horror films. The Noir influences can be seen in the distorted framing of characters' faces and New York City terrain, giving an atmosphere of ominousness at all times (an echo of Nina's attitude about the world). The horror/thriller movie influences are found in many scenes in which Nina is alone and her fragile mind begins to buckle under the pressure. All the classic tropes are there - freakish "reflection" shots, see-it-now-you-don't jump scares, sound bridging that blends the noise of one scene into another - classic tricks designed to keep you, the viewer, as edgy and frightened as Nina. The message here is clear: professional artistry and/or athleticism can be more draining and hellish than a weekend at Camp Crystal Lake.
Of course, the film is also comprised of the signatures that have come to define Aronofsky. The influence of the director's more artsy and stylish early work (Pi, Requiem for a Dream) can be seen in the close-up shots and sequences of feet at work, nails being cut, dancers' shoulders and arms in motion and other areas of physicality and routine that Aronofsky manages to make feel precarious and edgy. The influence of The Wrestler, on the other hand, can be seen at points where the director presses the camera almost uncomfortably close on Nina, hovering just on or over her shoulder wherever she goes to the point (which I suspect is THE point) that a clear visual metaphor is established: to this character there is no outside world, only the world as it exists in her mind.
This would be an intriguing approach if Nina was a more intriguing character. However, sadly, for me, this was not the case. I will say that Portman delivers an impassioned performance in this film, in the sense that she wholeheartedly attacks the role in much the same way that her character is asked to attack a set of pirouettes at one point. Yet Nina is not what I would call a complex or interesting character - in fact, I dare say she is one-note: crazy. From the moment the film opens, it's clear that this person we are supposed to identify with and follow has an obvious screw loose - her mom has a screw loose, their home life is screwy (think Carrie) and Nina always seems to have her emotions screwed with by the one thing she is supposed to love: dancing.
Taken altogether, I found it hard to buy that this character - who never once in the film seems to enjoy what she's doing - would actually go to the lengths she does and sacrifice what she does to reach her goal. And, despite the overarching theme of negative transformation (which is quite literally prophesied at one point early in the film), the only transformation I saw in Nina was that of a girl who goes from being crazy to being crazier. This is not exactly a new trait of Aronofsky's work, but at least with some of his earlier entries there's a sense that at one point the characters were not the mess we see them as - that even if they don't go anywhere, they at least came from somewhere better to arrive where they are. Nina offers no sense of real transition - just the heavy-handed and obvious "transformation" into the embodiment of the titular creature, which again, is no surprise given how unbalanced the character is from the start.
I would place most of the blame for Nina's lack of depth (and the movie's) on screenwriters Mark Heyman, Andres Heinz and John J. McLaughlin - although for me, Portman's performance still carried too many shades of her Star Wars goody-two-shoes naive princess, combined with her "bad girl" performance from that SNL rap video spoof. Her portrayal of Nina, while good enough, is far from Oscar-worthy in my opinion - especially when her co-star Vincent Cassel slinks in and steals almost every scene right out from under her, playing a snobbish artist type who is equally as brilliant and passionate as he is manipulative, sleazy and even (arguably) abusive. Same goes for Barbara Hershey as Nina's mother, a woman who is bright and loving or dark and oppressive, depending on the minute. If anything, I would say Black Swan features some Award-worthy supporting performances - though let's not add Mila Kunis to that list; she basically plays the same free-spirited femme fatale we saw in Extract last year.
In the end, Black Swan is exactly like Nina herself: a beautiful mess of technical perfection that would reach greatness if only it was more interesting. It's a rare case where I feel I can shower praise on a director for his skill, actors for their performances, and still walk away unimpressed by the movie as a whole. Kind of like the chances of seeing an actual Black Swan: rare, but not impossible.
Black Swan trailer:


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When the Supreme Court unwisely ruled that some companies can decline on religious grounds to cover contraceptives in their employee health plans, it was interpreting not the 1st Amendment but a federal statute, the Religious Freedom Restoration Act.
That means Congress has the authority to revisit and change the 1993 law. It can and should do so, not just to overrule the court's decision as it affects healthcare for women but also to address other possible consequences of the majority's expansive holding that for-profit corporations are "persons" that can raise religious objections to complying with a host of laws. But haste in responding to the decision makes waste, as is evident in the incomplete proposal unveiled last week by Sens. Patty Murray (D-Wash.) and Mark Udall (D-Colo.)
That bill would prevent for-profit corporations from using the religious freedom law to deprive members of a company health plan of any coverage required by federal law. It also would preserve the "accommodation" offered by the Obama administration to religious schools and hospitals with objections to birth control. Under that compromise, if an employer signs a form expressing religious objections to providing the coverage, its insurance carrier steps in to do so at no added cost.
But the Murray-Udall bill is too narrowly focused on contraception and healthcare.
The court's ruling that "closely held" companies such as Hobby Lobby are protected by the religious freedom law has potential impacts beyond health coverage. In her dissent, Justice Ruth Bader Ginsburg worried that employers might also be able to cite religious reasons for discriminating in hiring. A thorough review of the law would address this question as well as the larger issue of whether for-profit corporations can assert religious beliefs in any context.
As for contraception, the full effects of the decision are still unclear. Justice Samuel A. Alito Jr. held out the possibility that female employees of companies such as Hobby Lobby might receive disputed forms of birth control under a variation on the compromise the Obama administration offered to religious schools and hospitals. But a few days after the ruling, the court temporarily allowed Wheaton College, an evangelical institution, to refuse to sign the form and, instead, communicate its objections in a letter to the federal government. If the court permanently decided to excuse Wheaton and other institutions from using the form, it might (as Justice Sonia Sotomayor warned) create an administrative problem. But that also won't be clear for some time.
The senators are right to want to undo the damage created by the court's radical reinterpretation of the Religious Freedom Restoration Act. But Congress needs to move with greater care and deliberation than the court demonstrated.
Follow the Opinion section on Twitter @latimesopinion


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