text:
Open Label Study of NVP+CBV Treatment in Women Who Have Received sdNVP for the pMTCT of HIV
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT00144157
Recruitment Status : Completed
First Posted : September 5, 2005
Last Update Posted : November 14, 2013
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
|Condition or disease
|Acquired Immunodeficiency Syndrome
|Drug: Nevirapine Drug: Zidovudine Drug: 3TC
|Phase 4
An open-label, single arm, multicentre study to determine the virologic and immunologic responsiveness of women, who previously received a regimen of nevirapine for the prevention of MTCT, to a regimen of nevirapine and ZDV+3TC treatment. As well as to evaluate the proportion of patients who fail this treatment at 24 and 48 weeks, and to evaluate the resistance profile of HIV isolates from patients who fail nevirapine and ZDV+3TC treatment.
Study Hypothesis:
When a drug leading to selection of a resistant viral population is withdrawn the original wildtype virus, over time, becomes the predominant virus again. However, low frequency (below level of detection) of drug resistant viral sub-populations may be retained which could mean that the drug resistant variant might reappear rapidly should the same drug be reintroduced as part of combination therapy at a later stage.Therefore this study is proposed to evaluate whether there is an impact of single dose nevirapine for the prevention of MTCT on the subsequent response to a standard HAART regimen that contains nevirapine.
trial 1100.1090
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|53 participants
|Intervention Model:
|Single Group Assignment
|None (Open Label)
|Primary Purpose:
|Official Title:
|An Open-Label Study of Nevirapine Plus Combivir® (ZDV+3TC) Treatment in Women Who Have Previously Received a Nevirapine Regimen for the Prevention of Mother to Child Transmission (pMTCT) of HIV-1.
|Study Start Date :
|June 2003
|Actual Primary Completion Date :
|July 2006
|Study Completion Date :
|July 2006
- The proportion of patients who fail to suppress viral load to 400c/mL or maintain a viral load 400 c/mL at 24 and 48 weeks. The mean change in HIV RNA measurement by 24 weeks.
- What type of resistance that develops Immunologic response to treatment Treatment safety Time to treatment and/or virologic failure 5.How many achieve viral loads<50c/mL
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|19 Years to 45 Years (Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
- HIV-1-infected non-pregnant women who received a nevirapine regimen, for the prevention of mother to child transmission, at least 12 months previously.
- Women of child-bearing potential must have a negative urine pregnancy test at the screening visit and ensure double barrier methods of contraception, which by definition will in all cases include the use of condoms, throughout the study period.
- CD4 cell count < 350 cells/mm3 and viral load HIV-1 RNA > 20,000 c/mL or any symptomatic individual (WHO stage 3) or the presence of any AIDS defining criteria.
- Documented HIV-1 positive status by a licensed HIV-1 ELISA test.
- Women who are pregnant or breastfeeding.
- Women with prior exposure to antiretroviral therapy, other than a nevirapine regimen for the prevention of mother to child transmission at least 12 months previously.
- Subjects who in the investigator's opinion are unlikely to complete the 48 week study period or unlikely to comply with the dosing schedule and protocol evaluations.
- Patients with a Karnofsky performance status score < 70.
- Subjects who fail to meet the HIV treatment criteria (CD4 and viral load) indicated above.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00144157
|South Africa
|Boehringer Ingelheim Investigational Site
|Capetown, South Africa, 7925
|Boehringer Ingelheim Investigational Site
|Parow, South Africa, 7505
|Boehringer Ingelheim Investigational Site
|Soweto, South Africa, 2013
|Study Chair:
|Boehringer Ingelheim Study Coordinator
|B.I. South Africa (Pty.) Ltd.
|ClinicalTrials.gov Identifier:
|Other Study ID Numbers:
|First Posted:
|September 5, 2005 Key Record Dates
|Last Update Posted:
|November 14, 2013
|Last Verified:
|November 2013
Acquired Immunodeficiency Syndrome
HIV Infections
Immunologic Deficiency Syndromes
Immune System Diseases
Lentivirus Infections
Retroviridae Infections
RNA Virus Infections
Virus Diseases
Sexually Transmitted Diseases, Viral
Sexually Transmitted Diseases
Slow Virus Diseases
Molecular Mechanisms of Pharmacological Action
Reverse Transcriptase Inhibitors
Nucleic Acid Synthesis Inhibitors
Enzyme Inhibitors
Anti-Retroviral Agents
Antiviral Agents
Anti-Infective Agents
Anti-HIV Agents
Cytochrome P-450 CYP3A Inducers
Cytochrome P-450 Enzyme Inducers


text:
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subset: commoncrawl


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Annie Wald: An Allegory About Marriage
With her two daughters approaching marriage, Annie Wald wanted to share with them some of the hard lessons she had learned after years of matrimony. She found inspiration in the classic Pilgrim's Progress to write an allegory about the marital journey's challenges and rewards.
"I could tell a story instead of writing a memoir," says Wald, author of Walk with Me: Pilgrim's Progress for Married Couples (Moody/River North). "As a writer, I'm sort of steeped in allegory."
Wald, a former editor-in-chief at Princeton University Press, lives in Morocco and has been married for 35 years to Jack Wald, pastor of Rabat International Church there. She wrote the book and had it spiral-bound as a gift for the 2002 and 2004 weddings of their daughters. "I wanted to tell both the truth of our grace and of our selfishness," says Wald.
She and her husband kept meeting couples who were struggling in their marriages—"just as we had"—and the Walds would give them copies of the manuscript to encourage them. Last year, when Jack Wald was visiting the United States, he gave the book to a friend who told editor Deb Keiser at Moody/River North about it.
In Walk with Me, the characters Celeste and Peter are each traveling to the King's City. They fall in love and decide to become partners and be bound by the Cords of Commitment as they undergo both the journey and the process of being refined for their destination.
When they take a shortcut to avoid climbing the Mountains of Maturity, Peter and Celeste find themselves in the Swamp of Selfishness. They cross over the Bridge of Forgiveness many times and wonder just how often they must make that trip. They have to choose whether to stay together at all.
During her 12 years living in Morocco, Wald, who is now writing a novel, has become friends with people from all over the world, including people in arranged marriages. She observes that married couples share common struggles to love and forgive that transcend cultural and religious differences.
"People start their marriages with hope that their marriage will be different, and that their love will be stronger than the failures they've seen," she says. Though each marriage follows its own path, sooner or later all couples will endure internal and external stresses, Wald says.
In writing Walk with Me, she drew on the conflict and eventual healing she went through in her own marriage. Wald says it was a privilege to revisit the journey and be reminded of how God's redemptive wisdom and grace can transform a hopeless, broken relationship into a thriving partnership.
—Juli Cragg Hilliard
Amanda Davis: Youthful Phenom
At 19, Amanda Davis sold her first novel, Precisely Terminated, based on only one completed chapter. That chapter launched the Cantral Chronicles, a YA trilogy. The second book, Noble Imposter, was released in July, and Davis, now 21, is working on the finale, tentatively due to appear summer 2013. Davis, who says her youth helps her write YA fiction, won the 2012 Family Fiction Readers Choice first-place award for new authors.
The Cantral Chronicles is dystopian fiction, set hundreds of years in the future. In the trilogy, a group of nobles controls its slaves by implanting computer chips in their bodies. Hope for the slaves' freedom rests on Monica, a fugitive slave who has thus far avoided chip implantation.
The opening chapter of Precisely Terminated came to Davis in a dream and is replete with images evocative of Nazi concentration camps, including crowded bunks and mass gassings. "The crowded, terrible conditions of the camps along with the gassings were definitely reference points for me," Davis says. The books also share similarities with the Hunger Games—all are dystopian novels centered on a teenage girl, but, Davis says, a main difference is her trilogy's emphasis on hope. The first book ends with the rescue of thousands of people.
Although published by Living Ink Books, an imprint of Christian publisher AMG, the trilogy so far does not offer an overtly Christian message. This accords with AMG's strategy of trying to reach general audiences with Christian-themed books, says publisher Dale Anderson. As with C.S. Lewis's Chronicles of Narnia, the series' theme is foundationally Christian—good versus evil—with a clear line drawn between who is morally good and who is evil. The main character, Monica, displays Christian virtues of courage, self-sacrifice, and compassion toward others.
Rather than meticulously plotting her novels, Davis lets them unfold and surprise her. "I try to sustain momentum by always leaving questions unanswered until the end. There's always something left for the reader to wonder about. Mystery keeps the pages turning," she says.
Davis hopes the final book in the trilogy will be more overtly Christian, though she says she won't know how to do that until after she is done writing it. She hopes Monica won't die in the middle of the third book, as that would complicate the story.
Davis learned writing from her father, Bryan Davis, author of the Dragons in Our Midst YA series for the Christian market. "He gives me lots of advice and help with my novels, though I'm never willing to show them to him until they're completely written," Davis says. "He reads every word of my novels before they go to print and gives suggestions and changes for me to consider. I've been on a thousand different book tour events with him, listening to his author talks and writing seminars hundreds of times."
Of the final book in the Cantral Chronicles, Davis says, "I really like the idea and plot, but since I started writing [it] when I was 15, it needs a complete rewrite before I'm willing to show it to anyone. It has been five years since I dreamed my idea, and I think I'm ready now to create an even more amazing story that will rock my readers' worlds."
—Diane Reynolds
John Swinton: Remembered by God
While working as a hospital chaplain, John Swinton visited many patients with dementia, who sometimes sat for long hours, seemingly lost to themselves and forgotten by others. But when he offered them communion or prayers, often they brightened and became more animated. Swinton recalled this experience when he entered academia, and the questions it raised became the basis of his newest book, Dementia: Living in the Memories of God (Eerdmans).
Swinton says the book revolves around two questions: what does it mean to be who you are when you've forgotten who you are? And what does it mean to know and love God when you've forgotten God? Swinton's conclusion: "Who we are is something beyond ourselves," he says. "Most of who we are is what we are as we're remembered by God."
Swinton recognizes that the topic of dementia can evoke fear, which sometimes results in denial or avoidance. But he says that the issue is a growing one, and many people are looking for ways to understand what is happening to their loved ones.
Today, Swinton, a professor of practical theology and pastoral care at the University of Aberdeen, Scotland, and founding director of the Centre for Spirituality, Health and Disability at Aberdeen, lectures and blogs on the topic of dementia for a wide variety of audiences. The center is designed to develop research projects with a practical focus that draw on academic knowledge; Swinton's book was one of those projects.
"I hope readers can take away from the book that dementia isn't hopeless," Swinton says. "It may be painful, but there can be hope. We can develop the types of communities that enable people to be remembered. There is a tremendous sense of isolation, and dementia has as much to do with being forgotten as it does forgetting." Swinton's book offers insight into practical, pastoral issues, as well as a deeper look at the theological implications of the disease. "When you get down to it, you're really asking, what does it mean to be a human being, and a human being before God?" Swinton says. "It's a theological book but it aims to change practice, to understand better, and to practice better."
Swinton's own understanding of dementia has grown since he began his work on the subject. "When I began to research dementia I was afraid of it; by the time I finished I was less afraid." he says. "I'd seen so many examples of bad practice, but I was also afraid because to lose your memory seems to mean you lose yourself. But I know even if I forget everything I know, I remain myself. And it helps to have the right people around you." —Kerry Weber
MaryAnn McKibben Dana: A Day of Rest
As a part-time pastor of Idylwood Presbyterian Church in Falls Church, Va., MaryAnn McKibben Dana knew it was important to keep holy the Sabbath day. But as a wife, writer, and mother of three, finding time to actually do so sometimes proved to be a challenge. As her children grew, Dana felt "it was harder to find moments to be present with them," and found herself caught up in "that harried experience of jamming feet into shoes and getting the kids out the door to whatever activity." She recognized that her family needed a change. Dana considered cutting back on work or moving to a new city, but realized that, rather than drastic action, her family simply needed "a day to let go of that stuff and rest and play and be together." Her efforts to achieve that are chronicled in the book Sabbath in the Suburbs: A Family's Experiment with Holy Time (Chalice, Sept.; reviewed in this issue).
"I wanted to take this on for myself and to look at, practically, what does it mean not to work on the Sabbath," Dana says. "Especially when you have little kids who need to be entertained." For Dana's family it meant reconsidering technology use, cutting back on errands, and doing a lot of planning. She began to see the Sabbath as more of a mindset than a day of the week. "What Sabbath does is give us permission to do what we don't give ourselves permission to do the rest of the week," Dana says. "We need to get rid of the separation between sacred activities and secular activities. The things we did on Sabbath became sacred for us. My husband brewed beer. This might seem heretical to some people, but it was really restorative for him."
These days Dana's schedule is beginning to fill up once again. She is leading workshops and speaking at various churches about the book. She's also working on a Web site that will offer inspiration and online coaching for families and individuals looking for support and accountability while they pursue a similar spiritual goal. Chalice also has produced a notepad that offers the option of creating a to-do or a to-don't list to help support readers' efforts. Sabbath in the Suburbs will also be available in e-book format, and Dana is considering using Skype to join book group discussions.
Dana still tries to make time for rest, even though refraining from e-mail and overlooking piles of laundry in the name of the Sabbath can be complicated—a reality she tried to convey in the book. "What I sought to do is to find those moments where it felt beautiful and effortless, and also the moments where I wanted to tear my hair out, and put all those together in a portrayal of how honest and awesome the Sabbath can be and how difficult it can be," she says.
—Kerry Weber


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Need a job? The city needs bus drivers.
A teen with a machete gets the Taser treatment from APD.
A lawyer in Mississippi was thrown in jail for not saying the Pledge of Allegiance.
Year 10 of war in Afghanistan.
Soldiers and scientists may have figured out what's killing the honeybees.
A bill to help banks snuck through the Senate with no debate.
Very thin women make way more money.
Why does everyone hate the weather so much?
A Pakistani diplomat says President Obama exaggerated the terror threat to Europe.
Hispanics will likely vote Democrat this year.
Forbes named the first lady the most powerful woman in the world.
Toxic red sludge reached the mighty Danube in Hungary.
Got to read books by Mario Vargas Llosa. He just won the Nobel for literature.


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In the short webcomic Outfoxed, a laundress saves a talking fox from a foxhunt. But then the fox decides that he should become a man and fall in love with the laundress – and she must love him back.
Dylan Meconis delivers this folktale-inspired story of foxes and men. A laundress hauling her customer's clothes down a long road encounters a fox who begs her to hide him from a trio of hunters. She obliges, hiding him in her laundry basket. But after the hunters move on, the fox decides to forsake his vulpine existence for a human one and decides the laundress should be his lady love. She insists, however, that she could never love a fox, and he sets out to prove that he's no longer a fox.
If you're in the mood for more historically minded, flights of fancy, check out Meconis's longform webcomics, Bite Me, about vampires during the French Revolution, and Family Man, which mixes werewolves and 18-century German theology.


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A miffed Pakistan has threatened to pull out of the FIH Junior World Cup to be held in India later this year, a day after the Indian government has cancelled the proposed bilateral series between the two nations.
"We may pull out of the Junior WC to be held in India in December. Enough is enough and we can't take this anymore," Pakistan Hockey Federation general secretary Asif Bajwa said.
"This is happening again and again. First they send our players back without even giving them a chance to play in a single match in the Hockey India League and now this," he told PTI Bhasha from Lahore.
The FIH Junior World Cup will be held in New Delhi at the Major Dhyan Chand Stadium from December 6-15 this year.
Bajwa's comments came after the simmering political tensions between India and Pakistan has prompted the Indian government to call off the upcoming bilateral hockey series between the two countries.
Pakistan was scheduled to tour India in mid-April for five hockey Tests, followed by a return visit by India.
But the Ministry of External Affairs has refused to give the green signal to the planned series, after the Pakistan Parliament passed a resolution against Afzal Guru's execution and the recent 'fidayeen' attack on a CRPF camp in Srinagar that left 5 CRPF personnel dead.
Bajwa also said that Pakistan will no longer take any initiative for the resumption of Indo-Pak hockey ties after the recent episode.
"Whatever we could do we have already done. We have done enough for the resumption of hockey between the two nations. Now India will have to take the initiative," he said.
Asked about the future of this much-anticipated series, Bajwa said, "It is upto India now. We were ready to send our team first but now if such bilateral series takes place in future, the Indian team will have to visit Pakistan first.
"It was a golden chance to reduce tensions between the two countries but India has closed the doors."


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Wednesday, May 1, 2013
Best Whiskey Review Ever
I started to list some of my favorite quotes, but it pretty much became a transcription of the entire video, so just watch it. If you have any favorite quotes, leave them in the comments.
And don't miss Tactical's reviews of other quality products like this shocking revelation that Charles Shaw Merlot isn't very good.
22 comments:
- Florin said...
Sku, this is too easy - let the man be.
- May 1, 2013 at 9:48 AM
- NewYorkJosh said...
I applaud Florin's compassion, but share your epicurean enjoyment of the review. I was so deeply moved. From the freezer and fridge, to the instant conjunction of tasting notes "smooth like water" and "has a LOT of character"...It's just too good to ignore...
- May 1, 2013 at 10:12 AM
...and THAT's why I don't do video tasting notes anymore!
Seriously, though, this guy has gone to at least as much trouble to get his views out here as me or any of the other who are making blog comments (though not as much as actual bloggers such as yourself). And while I certainly agree that there is some room for improvement in his presentation skills, his enthusiasm alone will cause me (and several others here, I betcha) to shell out eight bucks to try a bourbon we otherwise never would have. There are some pretty highly-paid touts, uh... consultants who have been less successful!
If we keep this up, the next time we see him might be the Colbert Report!
- May 1, 2013 at 10:44 AM
- AaronWF said...
I like the comment by Harry Rock: "A 4 year old can do a better review of a can of piss." I definitely laughed more at that line than at the video itself.
Is it really all that rare to find a published piece that displays such lack of talent? In these days of internet, I don't necessarily think so. I don't make a habit out of watching bad reviews, so for all I know, this may be the worst ever recorded. Still, he clearly means well...
- May 1, 2013 at 10:50 AM
This guy's review of Pappy 15:
"All I'm experiencing is the pure taste of the bourbon. I've never had bourbon before."
- May 1, 2013 at 4:56 PM
There are so many aspects of this guy's reviews that I love. Foremost is that he appears to be quite drunk during most of them. Thing is, intentionally or not this review made my afternoon -- so I hope he keeps them coming.
- May 1, 2013 at 5:14 PM
- mongo said...
i think my favourite thing about this maybe the burp at the 1:31 mark.
- May 1, 2013 at 8:09 PM
- Matt L said...
That Pappy 15 review makes me sick. Those are the guys that end up with bottles?!?! Wow. Criminal. "I've never had bourbon before"?? Mix it with some Coke redneck, it'll go great with your weed.
While it js comical, at least the guy reviewing Zachary Boone is trying. Might need to try some more stuff, maybe go to a tasting before he calls it "one of my best drinks." Maybe read some reviews of other whiskeys? What does "run through a wall" mean with regard to the aging of bourbon? Alright, that's enough for me. Watch out for those square looking bottles Sku, don't really see much of those...
- May 2, 2013 at 12:46 AM
- Matt L said...
Okay, the real review starts at 6:39. Watch that part.
- May 2, 2013 at 12:56 AM
(On the Pappy 15 review) This ass hat is exact type of noob that Chuck Cowdery is referring to when he talks about losers who listen to the "experts" on what to drink. They then buy pappy van winkle because they read a few web sites, and think they are experts. Its all about "avoiding any heavy lifting on the way to connoisseurship". Witness, fellow whiskey lovers, why we cant get any of this stuff.
- May 2, 2013 at 5:01 AM
- sku said...
I'd rather have a novice buy a bottle of Pappy and mix it with Coke than have an enthusiast buy a case and stick it in their basement...I believe that's the real reason you can't find the stuff.
- May 2, 2013 at 6:18 AM
Amen Sku.
- May 2, 2013 at 9:17 AM
- May 2, 2013 at 11:08 AM
+1 Sku
- May 2, 2013 at 3:26 PM
- Matt L said...
This is true Sku. Went to a distillery last week in KY that shall remain unnamed and the girl working in the gift shoppe told me the master distiller had 3 cases of Pappy 20. And this wasn't Buffalo Trace. Wow. That's quite a bit.
- May 2, 2013 at 5:52 PM
I don't know. While people are definitely hoarding the Pappys, in some way that would be the best of available options because eventually if you have 3 cases of Pappys 20 you will start buying something else, freeing up the market. I suspect that Pappys has simply become a status symbol amongst certain groups (Lawyers, executive types, etc) who don't really like whisky so much as they like to be seen having the best whisky. I think you see this occasionally with other whisky (I'm thinking Macallan 18, which has skyrocketed in price in the last 10 years). This is the worst option because it means that as long as Bourdain keeps pimping pappys on his show, it will remain the best, and guys who have no qualms about slipping the clerk a couple hundred dollars to put some aside will get all the pappys.
- May 3, 2013 at 5:06 AM
- Matt L said...
Never seases to amaze me how people will spend 5 or 600 dollars on a bottle at Bonhams or on Craiglist when there are a few bottles to be had here and there if you do some groundwork and have some luck. I think some people almost WANT to spend ridiculous amounts on a bottle. Gives them even more to brag about.
- May 3, 2013 at 8:10 AM
I'm content to drink my Weller 12 and Elmer T. Lee and be happy. The market will decide. I suspect only those sitting on S-W juice will see any real appreciation long term. As the wise Jason sez, "drink your bourbon."
- May 3, 2013 at 9:42 AM
Wow. "Better than Jim Bean and Gentlemans Jack."
- May 3, 2013 at 10:36 AM
- politicalidiot said...
Made my morning. Hilarious.
- May 5, 2013 at 12:30 PM
- politicalidiot said...
BTW...his Elijah Craig review is even BETTER!
- May 5, 2013 at 1:01 PM
No one is impressed by a home run hitter grand slamming a slow softball by a novice pitcher.
- May 5, 2013 at 2:50 PM


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A new subatomic weight scale can measure masses as tiny as one yoctogram. Less than the mass of a proton, a yoctogram is equivalent to a billionth of a billionth of a millionth of a gram.
A yoctogram is so tiny that it's effectively the endpoint of the metric system - there aren't any prefixes to describe units smaller than it. Until now, the most sensitive scales could only determine an object's mass to within 100 yoctograms. Admittedly, while 100 yoctograms is a perfectly decent margin of error for, well, everything we encounter in the world around us, at the atomic scale it's a bit like giving your weight to within the nearest ten tons.
All these ultra-tiny scales rely on nanotubes, which will vibrate at a specific frequency depending on the mass of the particles resting on them. As New Scientist reports, improving these nanotubes in turn allowed for the creation of even more sensitive scales:
To go even lower, Adrian Bachtold and his colleagues at the Catalan Institute of Nanotechnology in Barcelona, Spain, used short nanotubes. They give the best resolution and work at the low temperatures thought best for measuring frequency. Although the equipment was placed in a vacuum to minimise interference from other atoms, Bachtold removed any stray atoms by temporarily turning up the heat on the tubes to disrupt any bonds to atoms. Then the sensor was able to weigh an atom of xenon to the nearest yoctogram, or 10-24 grams. This makes it the first scale capable of detecting a single proton, which weighs in at 1.7 yoctograms.
Much as it might be fun to weigh oneself to the nearest proton, Bachtold says the main use of these scales will be in distinguishing nearly identical elements in chemical samples. There are also some potential medical applications, as certain molecular disease markers are only distinguishable at the proton scale.
Nature Nanotechnology via New Scientist. Image by Anteromite, via Shutterstock.


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Trex World, part 21Submitted by kelson.philo on Tue, 05/08/2007 - 13:51.
Part 21
Link to part 1
Those whores, those autocratic little whores that were the fibrous stroma of the all seeing eye of Panopticon Productions Ltd, from the tubes they spewed, the executive and the cred-worthy, bursting forth on the lower floors to upper, upper and ever upper, straight up to their offices to manage the flow of product to customers throughout the Expanse and beyond to the various and sundry dwellings within the Capillaries. Silly questions were never asked, silly answers never given, all was movement and a stoppage would be registered as a clot and dealt with via omnitrexing scalpel. Scalpels of society, scalpels of financial status. And all the surgeons were locked up tight in offices Paul would never see, could never hope to see this late in his game. But like the pressure of bowels seeking release, he knew they were there, waiting for him to make one more critical mistake.


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Parsing MQ message data to interface with XI
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By Caroline McGraw [1] Apr 18, 2012 0 [2]
The Architecture of Change: The Madison House Autism Foundation
Imagine a space filled with sunlight, a modern cathedral of glass. The unexpectedly lovely interior is part of the Johns Hopkins University Montgomery County [3] campus in Rockville, Mayrland, and from April 2 through June 1, 2012, it is also the home of an art installation sponsored by The Madison House Autism Foundation [4] entitled, "Autistic. Artistic. A Life Ahead." In the words of JaLynn Prince, co-founder and president of The Madison House Autism Foundation, "The thing that was so remarkable about [the opening of the show] was that people didn't want to leave. They had to usher us out, because the building was going to lock electronically, and we would have been shut in for the night!"
I can understand the sentiment. Though Prince and I have just a few minutes to walk through the installation, I, too, am reluctant to depart. Prince's fine arts background comes to the fore as she describes each of the artists' works on display; her stories make the soaring space seem more personal. The extra space was necessary, as the opening night of the exhibit had approximately 150 people filling this area. Guests included artists on the autism spectrum, parents, autism advocates, and local community leaders. The exhibit featured original paintings, mixed media pieces, and jewelry by autistic artists.
The "Autistic. Artistic. A Life Ahead." exhibit can be viewed as a small-scale model of what the Madison House Autism Foundation hopes to achieve through their work. The Foundation's task is twofold: to raise awareness, and design and build new, supportive societal structures for individuals with autism and their families.
The Seeds of Change
The Madison House Autism Foundation's mission for change is far-reaching, yet like so many nonprofits, the seeds were sown at home. In Prince's words, "The Madison House Foundation began because we had a son [Madison] on the spectrum. We wanted to step forward with our lives' experience to help [others]. We'd originally thought we'd do a school, but then, when we did a survey, we found that adults on the spectrum is an area that's been highly neglected. It also happens to coincide with the age of our son; he's graduating from high school at the age of 22."
Prince's initial idea for a school for individuals with autism has transformed into a kind of school for society. The Madison House Autism Foundation seeks to provide hope, guidance, and effective solutions for adults with autism and their families. The emphasis is on providing choices, creating a world in which adults with autism are welcomed and included in every area of adult life. Begun in 2008, the Foundation focuses on projects that, in Prince's words, "...could bring great peace to parents and grandparents [of adults on the spectrum]. We love to have [family members] channel energies in our direction."
As families like Prince's know, simply trying to understand the existing system of services for individuals with autism can be a daunting challenge. As Prince says, "We're fairly informed people, and we've found the difficulties of navigating the [government] system, and have encountered many across the country who have had similar difficulties. People are concerned with what's going to happen to their adult children when they're no longer around. We're working to formulate a plan where individuals on the spectrum can have long, productive lives."
As such, the current art installation connects to the Madison House Autism Foundation's mission in that it is both a celebration of individuals and a showcase of talent. It is an open door for the possibility of career options. This balance of the emotional and the practical is one that the Foundation strives to strike. Though Prince and her colleagues were motivated to begin the Madison House Autism Foundation because of their personal relationships with individuals on the spectrum, they make it clear that the work that they do looks beyond individual relationships and into the realm of the abstract. As Prince says, "We're not a care provider—we're kind of an architect. We're trying to draw up plans to see what the building [the structure that supports adults on the autism spectrum] can look like in the next 60 years. We use the idea of 60 years, because from the age of 21, it's 60-plus years in a typical lifespan." Given the number of young adults with autism who are transitioning into this "next phase" of their life and aging out of support programs, the need for new societal structures is clear.
Person-Centered on a Larger Scale
Why choose to be an architect of the abstract given that there are such tremendous, concrete day-to-day needs at hand for adults on the spectrum? Prince and her colleague Adrienne McBride know firsthand that parents and caregivers expend a great deal of energy simply getting through each day. Prince recounts the period when her son Madison went to camp for the first time two summers ago. In the hushed, awed whisper that caregivers know so well, she says, "We had six weeks! [My husband and I had] six weeks of going out whenever we felt like it, of choosing a restaurant by ourselves ..." Even as her organization focuses on larger questions, Prince recognizes the importance of smaller-scale ones, such as practical support and respite for full-time caregivers.
Likewise, McBride tells me, "That's the main thing I see across the board, when I talk with parents; they are tired. And I don't mean tired as in simply physically tired, though that's true as well … I mean that they are ..." She trails off, searching for the right phrase.
"Deep-down tired? Soul-tired?" I suggest.
"Yes, exactly!" she exclaims. As a sibling of a young man with autism and a former full-time caregiver for adults with intellectual disabilities, I know just what she means. In that spirit, I can see how a group of people devoted to the larger questions of autism in our society offers parents and caregivers a ray of hope (and a modicum of relief) amidst the myriad of daily struggles they face.
Given the scale of their work, Prince is careful to note that the Madison House Autism Foundation continually seeks input from parents and caregivers. Recently, for example, the Foundation welcomed three roundtables of parents to offer feedback on their newly redesigned, interactive website. When I ask whether the Foundation's approach arises from a person-centered perspective, Prince says, "We want to be person-centered in the sense of looking at what is happening across our country. We need to provide information so parents don't feel as alone. We want to connect with a whole lot of other people across the country, putting people together, in a gigantic dot-to-dot."
Current Projects
In that spirit, the Foundation is working on several significant projects. First, the organization is involved in adult autism research. Says Prince, "We still don't have enough research on what happens to the adult with autism as they age." Next, the Foundation is collaborating with universities to formulate educational programs and curricula for individuals on the spectrum, in response to the growing need for continuing educational programs for adults with autism. Prince speaks with excitement about working with universities to "identify professions that have never been identified before." The Madison House Autism Foundation also directs families to financial planning and recreational resources, helping to answer questions related to housing. They continue to evaluate models from communities across the country that include farms, houses, apartments, and other community-based care models.
Prince mentions several practical societal shifts that need to occur for the world to fully welcome, include, and support adults with autism. These changes include advocating for medical school curricula to educate their physicians on the needs of individuals with autism. As Prince says, "If somebody can't stand a blood pressure cuff, loud noises, florescent lights, changing into a [hospital] gown … it sounds trivial until you're with someone who is having a total meltdown, someone who needs medical care and can't get it because the people who are trying to give care to that individual don't know what to do!" Thus, the Madison House Foundation is also working to inform and educate first responders in their local community. Likewise, Prince suggests changes such as having "quiet areas" in Emergency Rooma to help individuals with autism dealing with sensory overload, and limiting the use of sirens and flashing lights unless they are absolutely necessary.
The overarching theme to the Madison House Autism Foundation's work is that of structure—they hope to help articulate what the next generation of supported living might look like. And, in collaboration with other thought leaders in the autism world, Prince says, "We're going to have to call in a lot of good people to help reinforce that structure."
Support for Families
Additionally, the Madison House Autism Foundation has begun a Parents Network, which Prince calls "a fledgling project." The Foundation is in the process of editing videos of parents detailing their experiences, which will serve as encouragement and support to parents across the country. In the past, Prince says, "We took a series of stories that parents had sent us to the White House, and they ended up on some important desks. We did it to put a real face on what autism is." Likewise, the Foundation's new website features an area for parents, siblings, caregivers, and individuals on the spectrum to share their stories. Future projects include a video series from a writer who is a parent of a son on the spectrum. In Prince's words, the series will be, "… a real-time view of what it is like to have a son graduate from high school who is on the spectrum, and what he will be facing. [The writer is] going to be very open about the recommendations that are made to her, the ones that succeed and the ones that fall on their face. Every few weeks, she'll write in in real-time, so other parents can see what [they're] going through."
When I ask Prince for her recommendations for parents of individuals on the spectrum, she suggests that parents, "… get a circle of friends together and talk to them very frankly—and maybe do this every couple of years, so they know each other, they know your child—and say, 'I don't want it to fall on any one person, but if something were to happen, would you be part of our son's community? Something as simple as sending a card, or as big as looking out for his welfare.' Nothing makes a parent happier than to know that somebody thought of their child."
Other practical recommendations from Prince include investing in wise financial planning early on; looking into trusts; and bringing people who can be trustworthy caregivers. On the whole, Prince counsels parents, "Be informed but trust your own instincts."
Ongoing Challenges, Dreams for the Future
The challenges that The Madison House Autism Foundation encounters are tied to those faced by parents and caregivers. Both Prince and McBride mention the difficulty of engaging parents and caregivers in conversations about the future, given the time and energy it takes for caregivers to work with the immediate things at hand. As Prince says, "When a parent has had an autistic child, and they've had to worry about bedtime, foods, school … how do they look to what the next phase is going to be? When parents are facing that lack of [societal] structure in addition to everything else, it's really challenging."
As such, a major part of the work of The Madison House Autism Foundation is to help families and individuals to move closer to a life of fulfillment for each individual. As Prince says, "I believe that the biggest tragedy in the world is when human potential is not realized. This is whether someone's on the spectrum or not. [I believe in] the idea of helping those that are on the spectrum reach their fullest potential, whatever that may be."
Realizing potential is a challenge in a world where autism services are insufficient and limiting beliefs abound. Even so, Prince sees the "Autistic. Artistic. A Life Ahead." show as a part of what will transform our world. "The art show brought people together; you could see misconceptions almost shedding off of people's shoulders. It was an experience understanding more about autism, and themselves in relationship to autism. If I could have a national art show, and salt and pepper it with conversations about autism, the world could relieve itself of a lot of fear and move forward in a positive way."
"It Would Be Great for Us Not to Have to Exist!"
When I ask Prince if she considers the Madison House Autism Foundation a replicable model for other communities, she encourages a larger view, and arrives at a surprising conclusion. In her words, "If there's other Madison Houses that's fine, but why don't we all define what we're doing, do the best job we can, and then fill in all the gaps? Let's learn from each other, and then we can move things forward faster. If we can have this national conversation—if we can get institutions, legislation, universities all working in a good direction for adults with autism—ultimately, it would be great for us not to have to exist!"
A nonprofit that looks forward to a future in which it might not need to exist? An organization that's both person-centered and ideological? The Madison House Autism Foundation seems a study in contradictions, yet this seems fitting for an organization that deals with the paradoxes of autism on a daily basis. This being the case, when I ask Prince about the best part of her work, I'm not surprised by her answer: "Having quiet moments, looking at my son, and thinking that maybe the future will be better for him and the other Madisons out there."
The Madison House Autism Foundation welcomes family involvement. Please visit the Parents [5] page of its website to learn more.
The "Autistic. Artistic. A Life Ahead." exhibit is on display at 9605 Medical Center Drive, Rockville, MD 20850 from April 2 through June 1, 2012. Visit The Madison House Foundation website [4] for more information.


text:
Ruben Blades and Gilberto Santa Rosa to perform in the Bronx
Gilberto Santa Rosa and Ruben Blades appear at Lehman Center for the Performing Arts
Lehman Center for the Performing Arts proudly presents a
special 30th Anniversary Season event by two living Salsa legends, singing side
by side on the same stage for the very first time – multi-GRAMMY Award winners
RUBÉN BLADES and Gilberto Santa Rosa – performing their major international
hits in the premiere performance of their Una Sola Salsa 2011 tour on Saturday,
February 26, 2011 at 8pm. The performing
arts center is located at 250 Bedford Boulevard West, Bronx, New York.
Ruben Blades also known as "El Poeta" (The Poet), is one
of the most successful vocalist/composers in the history of Latin music. Gilberto Santa Rosa, known as "El Caballero
de La Salsa" (The Gentleman of Salsa), is known for his unique style of "soneo"
(improvisation). This year Rubén Blades
and Gilberto Santa Rosa performed a duet on "Me Cambiaron las Preguntas," the first
song Santa Rosa ever recorded that focused on a social issue, for Santa Rosa's
new album Irrepetible.
Rubén Blades, who grew up in the working-class
neighborhood of Carrasquilla in Panama City, is a renaissance man who has made
a significant contribution to Salsa with his socially conscious lyrics. In 1968, he traveled to New York, where he
was invited to record an album with the Pete Rodríguez Orchestra, and made
important contacts in the music world.
After obtaining a law degree in Panama, he moved to the US in 1974,
staying with his parents in Miami before moving to NYC, where he was soon working
with band leaders Ray Barretto and Larry Harlow. When Héctor Lavoe left his position as lead
vocalist for the Willie Colón Orchestra, Blades took the spot, and their 1978
album Siembra became the best-selling Salsa record to date. He won his first of six GRAMMY Awards in 1986
for Escenas in the Best Tropical Latin Performance. Last November he received his second Latin
GRAMMY for Best Singer-Songwriter Album of the Year for his album Songs of
Underdevelopment. He has appeared in
numerous films, including "Crossover Dreams" (1985), "The Milagro Beanfield
War" (1988), "All the Pretty Horses" (2000) and "Once Upon a Time in Mexico"
(2003). He was Panama's Minister of
Tourism from 2004 to 2009.
Gilberto Santa Rosa, born in Carolina, Puerto Rico,
watched El Gran Combo on television and as a teenager studied sax and trumpet
at the Escuela Libre de Música de San Juan.
He founded his first musical group, La Evolución 65, which later would
become La Potencia Orchestra. After two
years with La Grande Orchestra, he made a name for himself singing with Don
Perigñón, Manolito Rodríguez's Fantasía Boricua, Tommy Olivencia's La
Primerísima and the Puerto Rico All-Stars.
With Willie Rosario he achieved major success with such hits as "Lluvia"
and "Botaron la pelota." In the mid-1980s,
Santa Rosa led his own orchestra and released four albums before signing with
Sony BMG, which is still his label. His
delivery and talent for lyrical improvisation spurred the Salsa movement,
revolutionizing the genre and launching the pioneering singer to an
international level. In 1995, he made
history when he became the first tropical music singer to perform at Carnegie
Hall, and in 1998 he recorded the first Salsa album with classical orchestra,
Salsa Sinfónica with the Orquesta Sinfónica de Venezuela. Santa Rosa topped Billboard's music charts
with 1999's stand-out Expresión. His
success continued with the albums Romántico, Intenso, Viceversa, Sólo Boleros,
Auténtico and 2006's Directo al corazón, which won both GRAMMY and Latin GRAMMY
Tickets for Una Sola Salsa with Ruben Blades and Gilberto Santa Rosa on Saturday, February 26, 2011 at 8pm are: $105, $95 and $75 and can
be purchased by calling the Lehman Center box office at 718.960.8833 (Monday
& Wednesday – Friday, 10am–5pm, closed on Tuesdays, and beginning at 12 noon
on the day of the concert), or through 24-hour online access at
www.LehmanCenter.org. Lehman Center is
accessible by #4 or D train to Bedford Park Blvd. and is off the Saw Mill River
Parkway and the Major Deegan Expressway.
Free on-site parking is available.
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I think you have "Filtered HTML" turned on here. If you switch to "Full HTML," it will probably...
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Error 8AC80001 occurs when you use the microphone on the Kinect Sensor
You see the following error code and message when you use the microphone on the Kinect sensor:
Microphone calibration was still busy from the last time that it was run
This may mean that the Kinect sensor is busy.
Solution 1
If you see this message, wait 90 seconds before trying to use the sensor again.
Solution 2
If you have waited 90 seconds and the message still appears, try restarting your console.
Solution 3
If the previous solutions didn't resolve the problem, see Troubleshooting Kinect audio problems for help with audio calibration
Solution 4: Contact Xbox Support
If you keep experiencing this error, contact Xbox Support by clicking the "Contact us" link at the bottom of this page.
Solution 5: Request a repair
If the previous solutions didn't work, sign in to request a repair and click Start request.
Repair or warranty questions? See Xbox 360 warranty, registration and repair: Frequently asked questions.
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text:
Talk:1063: Kill Hitler
Actually, I think the joke here is that Black Hat actually did end Hitler's atrocities, but that history is not actually changeable. Hitler's "suicide" was actually Black Hat killing him. This is then layers with the impossibility of changing history. This would imply that anyone that wants to stop Hitler before he rose to power will be circumvented.
UnaSalusVictis (talk) 01:26, 25 November 2012 (UTC)UnaSalusVictis
True, killing Hitler before he rose to power and committed all his atrocities would cause a Grandfather paradox... Cueball invented the time machine and send Black Hat back because he wanted Hitler dead, but if Hitler died before that, there would be no reason to invent the time machine and send Black Hat back which ergo cause the initial trip to kill Hitler not possible and ergo Hitler couldn't die before he rises to power and committed his atrocities. 188.8.131.52 01:40, 5 December 2012 (UTC)
Maybe in the original timeline, Hitler's atrocities extended beyond 1945. When Black Hat went back in time and assassinated Hitler in 1945, all of the history in between was re-written. When Black Hat returned to the current date, he returned to a different timeline than the one he left. In this timeline (ours), Hitler died in 1945, and because this timeline is based on that fact, Cueball thinks that Black Hat has not changed anything, when in fact, Black Hat's actions created the new timeline. 18.104.22.168 15:00, 7 December 2012 (UTC)


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Visa information for Algeria nationals travelling to Equatorial Guinea on business
Please complete the fields below to email a 'DJB Application Pack' with all forms and templates attached.
The following documents are required for a business visa for Algeria nationals travelling to Equatorial Guinea.
All applications must be accompanied by an RLP Order Form.
Visa requirements
- Valid passport
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- 3 passport photos
- UK visa permit
- 1 months bank statements
- Application form (download)
The usual processing time for visas of this type is 3 working days.
Additional information
- A Criminal Record Background check is required
- 3 copies of the Application Form, Business Letter, Invitation Letter, Flight & Accommodation are required for processing
Embassy details
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St. James'
Phone: +44 (0)20 7499 6867


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When Google launched the Google Plus One button, many webmasters and SEO professionals were curious as to how this tool would affect their web page rankings. Most bets were placed on it being important; after all, the social signals coming out of popular social networks like Twitter and Facebook carry so much weight these days. But no, Google Plus One clicks carry very little weight and, according to a recent interview with Matt Cutts (head of webspam at Google), have very little effect on your rankings:
In the short term, we're still going to have to study and see how good the signal is. Right now, there's not really a direct effect where if you have a lot of +1s, you'll rank higher.
The failure of the +1 clicks to provide accurate social signals stems from Google's dismal social network. Over a billion people now use Facebook and its 'like' button to give search engines a wealth of social data. In contrast, hardly anyone uses the Google Plus social network and its associated +1 button. Search engine users may be confused by + 1′s, which differ from the Facebook 'like' button which directly shares content to a user's social stream. They may also be put off by the spammy nature of the buttons, which appear next to search results in Google and on websites fooled into teaming up with Google Plus.
The +1 feature was designed by Google to help people discover and share relevant content from the people they already know and trust. However, because so few people are using the feature to give their vote to search results, websites and advertisements, Google has no choice but to largely ignore its own creation.
Although Google +1 clicks have no direct impact on your ranking in search engines, they may offer a very slight indirect benefit by helping to increase click-through-rate (CTR). The logic is that people will be more likely to click on a search result that display a higher number of +1′s, or click links that are recommended by your friends (the catch being that you have to be signed into Google Plus and your friends have to be using the service for this to work).
This is not the first time Cutts has downplayed the significance of the +1 button with regards to ranking. At the SMX Advanced conference in June, he said:
When we look at +1, we've found it's not necessarily the best quality signal right now.
Matt Cutts comments on authorship show that this could be a more important signal in rankings factors in the future. If your website contains content that can be attributed to a particular author, author verification could help your site:
There are things like, we have an authorship proposal, where you can use nice standards to markup your webpage, and you'll actually see a picture of the author right there, and it turns out that if you see a picture of the author, sometimes you'll have higher click through, and people will say, 'oh, that looks like a trusted resource.'
So there are ways that you can participate and sort of get ready for the longer term trend of getting to know not just that something was said, but who said it and how reputable they were.
If you look further out in the future and look at something that we call 'social signals' or 'authorship' or whatever you want to call it, in ten years, I think knowing that a really reputable guy – if Dan has written an article, whether it's a comment on a forum or on a blog – I would still want to see that. So that's the long-term trend.
However, the effect of a verified authorship on the rankings of your website seems to be quite low at current and could simply be an attempt to get more Google+ users.


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Halo 5 Beta
Posted 09 January 2015 - 08:48 AM
What a goddamn joke.
Posted 11 January 2015 - 02:09 AM
I know most of you won't be getting this regardless, but this definitely applies to all games. He says all of the truths. I'm done preordering.
Other than the reaffirmation of my philosophy against pre-orders (specifically designed to screw you over in the case of a botched launch), this video reminded me of one thing: Halo 3 is my favorite non-CE Halo game.
Posted 05 February 2015 - 03:21 PM
Here's a list of changes being considered/followed through with by 343i following the Halo 5 beta.
Here's Frankie's comment on the only 11% don't want sprint issue.
Now, I won't break NDA and say what was on the survey as I took it. But I will say that calling 11% a comprehensive number based on a pool of participants who had to opt-in through email is a bit suspect. I'm not going to sit here and pretend that there would be more people in favor of not having sprint, because we all know that simply isn't true. But to throw your weight around and act like "see, told ya' fuckers no one wants sprint!" is a bit dishonest at best. I know that getting people to do online surveys (especially with lack of compensation) is a difficult task. But I do think we all would've been better served by 343i doing a survey from within the Halo 5 beta open to all.
I'd personally feel a lot better about the survey if 343i put the results out there. They have no reason not to do so, it's not hyper-sensitive data. Cherry picking results works when you're in a board meeting, sure, but when you're presenting data to be scrutinized it's bad when you don't present all the pieces.
Edited by Nightshade, 05 February 2015 - 03:54 PM.
Posted 05 February 2015 - 03:55 PM
So while they are giving us an option to remove the Spartan abilities, it still begs the question as to how these maps will play now because of how much bigger they are. Plus the fact if they will even include an online matchmaking mode without said abilities.
I do, however, like that they are increasing the base player speed, bringing back the original rocket launcher, making "smart link" more neutral & less visible (of course we'll have to see what this means exactly), and decreasing the medal count.
This still doesn't give them any brownie points from me, nor will I still buy this day one. They still have a lot to prove this time around first. One of them being a working lobby/matchmaking system.
Posted 06 February 2015 - 02:13 AM
I didn't play after the first week of beta, so I am not H5 fanboy. I probably will not buy the game on release.
But as much as we like to bash 343, they deserve props for actually being flexible. I too am unsure how the game will play with the bigger maps/without sprint (probably less than ideal), but I don't think we could expect anything else. They are making the game they want to make ultimately, and there is something to be said for devs sticking to their vision.
I suspect that it will have a modest reception at launch, but I think it would have been the same had they done a classic Halo. The series just doesn't have the clout it once did.
Edited by phreak, 06 February 2015 - 02:17 AM.
Posted 06 February 2015 - 03:43 PM
Posted 07 February 2015 - 09:50 AM
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