text:
This phase I trial is studying the side effects and best dose of lenalidomide in treating
young patients with recurrent, progressive, or refractory CNS tumors. Lenalidomide may stop
the growth of CNS tumors by blocking blood flow to the tumor. It may also stimulate the
immune system in different ways and stop tumor cells from growing.
I. To estimate the MTD of oral CC-5013 administered to children with recurrent or refractory
primary CNS tumors once daily for 21 days of a 28 day course.
II. To describe the toxicity profile and define the dose-limiting toxicity of CC-5013 in
children with recurrent or refractory primary CNS tumors.
I. To characterize the pharmacokinetics of CC-5013 in children and adolescents. II. To
characterize the pharmacogenetics of CC-5013 in children and adolescents.
III. To evaluate changes in circulating endothelial cells (CECs) and circulating endothelial
cell precursors (CEPs) in patients treated with CC-5013, and to investigate the correlation
between changes in CECs and CEPs, plasma, serum and urine levels of proteins associated with
angiogenesis including thrombospondin, b-FGF, TNF-α, IL-12, IL-8 and VEGF, and correlate
these changes with changes in MR perfusion and clinical outcome.
IV. To evaluate changes in MR perfusion and diffusion during treatment.
OUTLINE: This is a dose-escalation, multicenter study.
Patients receive oral lenalidomide once daily on days 1-21. Treatment repeats every 28 days
for 24 courses in the absence of disease progression or unacceptable toxicity.
Cohorts of 2-3 patients receive escalating doses of lenalidomide until the maximum tolerated
dose (MTD) is determined. The MTD is defined as the dose at which an estimated 25% of
patients experience dose-limiting toxicity.
All patients are followed for at least 30 days after the last dose of lenalidomide. Patients
with treatment-related toxicity are followed for up to 3 months.
Inclusion Criteria:
- Patients with a histological diagnosis of a primary CNS tumor (including
histologically benign brain tumors (e.g. low-grade glioma) that is recurrent,
progressive, or refractory to standard therapy; patients with intrinsic brain stem or
diffuse optic pathway tumors do not require histological confirmation of disease but
should have clinical and/or radiographic evidence of progression
- Karnofsky Performance Scale (KPS for >= 16 yrs of age) or Lansky Performance Score
(LPS for ≤ 16 years of age) ≥ 60 assessed within two weeks prior to registration
- Patient must be able to swallow capsules
- Patients must have recovered from any significant acute toxicity associated with
prior therapy; patients must have no known curative therapy available; patients will
be eligible regardless of the number of prior therapies, as long as other eligibility
criteria are met
- Chemo: Prior use of thalidomide is acceptable; patients must have:
- Received their last dose of known myelosuppressive anticancer chemotherapy or
biological therapy at least three (3) weeks prior to study registration
- Received their last dose of nitrosourea or mitomycin-C at least six (6) weeks
prior to study registration
- Received their last dose of other investigational agent or an anticancer drug
known to not be myelosuppressive at least seven (7) days prior to study
- XRT: Patients must have had their last fraction of craniospinal irradiation ≥ 3
months prior to registration and their last fraction of local irradiation to primary
tumor ≥ 4 weeks prior to registration
- Bone Marrow Transplant: ≥ 6 months since allogeneic bone marrow transplant and ≥ 3
months since autologous bone marrow/stem cell prior to registration
- Growth factors: Off all colony forming growth factor(s) > 2 weeks prior to
registration (filgrastim, sargramostim, erythropoietin)
- The following laboratory values must be assessed within two (2) weeks prior to
registration and again within seven (7) days prior to the start of therapy;
laboratory tests should be repeated within 48 hours of beginning therapy if there has
been a significant clinical change
- Absolute neutrophil count ≥ 1000/μl (unsupported)
- Platelets ≥ 100,000/μl (unsupported)
- Hemoglobin ≥ 8.0 g/dL (may be supported)
- Serum creatinine within upper limit of institutional normal for age
- Or GFR ≥ 70 ml/min/1.73m^2
- Bilirubin ≤ 1.5 times upper limit of normal for age
- SGPT (ALT) ≤ 2.5x institutional upper limit of normal for age
- Albumin ≥ 2 g/dL
- No overt renal, hepatic, cardiac or pulmonary disease
- Female patients of childbearing potential must have negative serum or urine pregnancy
test (sensitivity of at least 50mIU/ml); patients must not be pregnant or
- All sexually active females must begin 2 methods of birth control, including 1 highly
effective method, and 1 additional method (at the same time) at least 4 weeks prior
to the first dose of CC-5013; this applies to all sexually active females of
childbearing potential unless they have not had a menstrual period in 2 years or have
undergone a hysterectomy
- Patients of child fathering potential must agree to use latex condoms during
intercourse with a woman while taking CC-5013 and for 4 weeks thereafter
- Signed informed consent according to institutional guidelines must be obtained
Exclusion Criteria:
- Patients with a body surface area (BSA) ≤ 0.4 m^2 are excluded
- Patients with a first-degree relative with a history of venous thrombosis before age
50 yrs or an arterial thrombosis before age 40 yrs are excluded
- Patients who have had a thromboembolic event that is not line-related are excluded
- Patients with any significant medical illnesses that, in the investigator's opinion,
cannot be adequately controlled with appropriate therapy or would compromise a
patient's ability to tolerate this therapy
- Patients with any disease that would obscure toxicity or dangerously alter drug
- Patients receiving any other chemotherapeutics or investigational agents
- Patients with uncontrolled infection
- Patients unable to swallow capsules
- Patients with known hypersensitivity to anhydrous lactose, microcrystalline
cellulose, croscarmellose sodium, and magnesium stearate
Lenalidomide in Treating Young Patients With Recurrent, Progressive, or Refractory CNS Tumors
A Phase I Trial of CC-5013 (Lenalidomide) in Pediatric Patients With Recurrent or Refractory Primary CNS Tumors
Phase 1
21 Years
National Cancer Institute (NCI)
United States: Food and Drug Administration
Endpoint Classification: Safety Study, Interventi
| All trademarks are property of their legal owners. | All Rights Reserved
ClinicalConnection.com is a resource that provides information on clinical trials conducted worldwide.
ClinicalConnection.com does not conduct or endorse clinical trials. Please consult your physician before participating.
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text:
Swann 400 external VFO question
Talk about anything that doesn't fit in a topic below - Also used for board announcements.
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Swann 400 external VFO question
Hello all, I am new to Ham radio and I just purchased a nice used Swan 400 tranceiver and it has to have an external VFO. Can anyone recommend a compatible VFO in the event that i can't find an original Factory unit? Thanks
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text:
Hey for our special friend Max whos travelling in India, here's a post just for him to catch up on tourney results:
Oxford Thingy – 09.05.09
1. SEX E – Dave (BAD), Sarah (Los conos), Andy-Lewosky
2. Cosmic Turd – Tomasito, Todd and Matt
3. Rotten Apples – Gabes, Em and Rik
words from guys guys guys (Andy formerly of mallertov cocktail)
"Awesome day. Without a doubt the best tournament I've ever been to, but I may be biased 😉 Cheers to all the Oxford guys for putting on a fantastic day. And it was great to meet all the Oxford, Cambridge and Manchester crews.
Props to Los Conos for reaching the quater finals and playing some awesome polo. And Rotten Apples and Cosmic were both wicked and should make the Euro qualifiers interesting.
Thanks also to my team mates. Sarah was an absolute rock in goal and allowed Dave and I to do our thing. And Dave is the best team mate you could hope to have. He both forces you, and helps you to play better, at the same time. Weird!"
pic of score board:
pic by Sarah of Los Conos
Rouen – 12.04.09
1 er Seattle Super Stars
2 ème BAD Polo
3 èmeFabulous French Fuckers
4 ème Dans Ta Gueule, Puceau.
words from Yorgo
"epic tourney. flawless organisation I must say, and great spirit from the London massive. Soon people will PAY us to come and enliven their polo events. The cheering in the BAD matches was great, the JiHaD vs Puceau match was monumental (or was it against another team? anyway Hassan was on fire), Bill & the ladies played about 7 games, fighting hard and winning most, Aidan showed the yanks how it's done, etc etc. Expect better reports from others as soon as they get past their hangover tmrw. Zombie Fail though. But Rollapaluza win! Super chuffed with the bike – thanks Winston & Caspar!!"
words from Mike Zombie
"Fuck! What happened to Sideshow?"
and words from Hoser Brian
"-The 4 am full moon reflecting off the lake in the french country side biking into Rouen.
-Hassan smashing out of goal to own the entire french team and score a beauty. BEST. GOAL. EVER.
-The old french couple who made us pizza. Can they come over and do our next fundraiser?
-Malletov vs. FFF…the best game of polo i've ever seen.
-Things in general.
-Losing to the Americans…so much fun to smash around and feel the London crowd cheer us on.
-Seeing Bianca more happy than I've ever seen her, and seeing Tomasito dive off his bike to score a goal. Holy Commitment Batman!!!
-Seeing Adain smile for a change.
-Red Wine, Cheese and Baguettes on the beach in Dieppe.
-The English Channel looking like a sheet of glass."
pic of score board:
pic by dunno
Manchester – 19.04.09
1st Seattle
2nd Malice
3rd Aidan, Jason & Dave
words from Nes
"just wanted to say thanks to everyone for coming and to everyone who helped make it totally fucking awesome…you all rule…it is my favourite day of all the festivals and one of my favourite days ever…i do however have sunstroke and feel sick…ah well x x x"
words from Dr Matt.
"Final game. Seattle v. Malice. 5-3. We had them up 2-1. They were relentless with a really tight close game in our goal. They played with three on offense a lot. Wish we could have broken out and popped a couple in that open goal.
Props to Seattle.m"
pic of score board:
Throw-up Tourney London – 25.04.09
Blame Mike for these long winded results:
"Making it through to the 2nd round was
Team 2: Bill, Nano and Zoe
Team Jo
A tie between Zombie Army and Boring meant a playoff for the wildcard spot which went to Boring. 3-5
2nd round games:
Skidmarx vs BNZ – 3-5
Team Jo vs Boring – 2-5
Winners bracket:
BNZ vs Boring – 2-5
Skidmarx vs Team Jo – 1-5
Team Jo vs BNZ – 5-0
Boring vs Team Jo – 4-5
Due to double elimination bracket, Boring had to lose twice…
Boring vs Team Jo – 5-4
Team Jo loses in 2nd round making Boring the winners.
YAY Boring! :)"
but on a good note no score board or match description needed.
words from Jonny formerly of Mallets of Hazzard
"cheers all for a great day of polo in the sun. nice one em, mike, bill and anyone else involved with organising, disorganising and organising. grats to the lovely seattle crew for bringing their style to the fray. big thanks to joel and anna for team JaJa. so cool that we managed to pull a win, against a side with the most drunken canadian ever, but it still counts.
quotes of the day. Pique "don't mistake my arrogance for confidence" and Shins "nothing"
wish i could have hung round for the apres polo but a prior appointment with the G beckoned.
more throw-in tourneys I say."
hope you're happy MAX.


text:
USD $200.00 Out of Stock
High polished silver plated earrings. Available in studs and clip-ons.
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For further information, please visit our PRODUCT CARE page.
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text:
From SELC_News Twitter
"Only major news item from the SELC meetings was @LibertyLax getting voted in as a member of SELC Division 1."
Liberty also stated they are going to be announcing a loaded schedule in the coming weeks. Flames made the Division II Semifinals last year. Will they follow Grand Canyon as making the tournament two years in a row, first as a DII member then DI?
Liberty 2014
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- All-America
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Liberty 2014
Re: Liberty 2014
Liberty Names Four Captains
Read the Full Story- http://mcla.us/news/2013/12/flames-desi ... 14-season/
Lynchburg, Va. - As a semester of preparation for its transition to MCLA Division I draws to a close, Liberty University's men's lacrosse team has designated its four captains for the fast-approaching 2014 season.
Liberty will compete in the North West Region of the SouthEastern Lacrosse Conference, replacing the University of Richmond, now an NCAA Division I program. After capturing its first SELC Division II Tournament championship last year, the Flames will seek to repeat those feats against new rivals and defending SELC DI North West Region champion Virginia Tech as well as Kentucky, West Virginia, Tennessee, and George Washington, a team it defeated 11-8 in a fall exhibition rematch of last season's 17-5 triumph in Washington, D.C.
Fourth-year Head Coach Kyle McQuillan is confident the Flames will make a successful jump from Division II, where they wound up ranked No. 3 in the final MCLA poll after reaching last spring's MCLA Tournament semifinals.
A large reason for his optimism is the leadership provided by newly appointed captains Mike Zumpano, Kurt Tobias, Ethan Kamholtz, and Brandt Grauss.
Read the Full Story- http://mcla.us/news/2013/12/flames-desi ... 14-season/
- All-America
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text:
The Coolest Actors Ever
As movie fans, we like to think of our favorite actors as being larger than life. With all of the coverage that these stars get, these cool customers know how to function both on and off the screen. Often times we think of our favorite actors as being fairly close in personality to our favorite characters to whom which they portray. Obviously it's impossible for them to be a lot like their famous portrayals, but that doesn't mean that these guys aren't cool. In fact, most of these guys epitomize what cool is. Beginning with actors like Humphrey Bogart and Cary Grant during the Golden Age of Film, the best leading men have had a certain aura about them. James Dean, Marlon Brando and Steve McQueen are other actors who are considered some of the coolest guys ever.
More recently, tough guy actors like Bruce Willis and Daniel Craig mix brains with brawn in their iconic roles as John McClane and James Bond each. While they each exemplify a different kind of cool, people are still attracted to these actors because this coolness factor. These actors of the guys who you'd want to hang out with, talk shop and maybe down an adult beverage or two with.
Vote for who you think is the coolest actor ever. If you don't see a name on this list and the actor is cool, feel free to add a name to the legendary list of the coolest people history.


text:
|Jepson Flora Project: Jepson Interchange
previous taxon |
next taxon
Jepson Interchange (more information)
©Copyright 1993 by the Regents of the University of California
Annual to tree
Leaves basal or cauline, alternate, opposite, or whorled, generally simple and toothed (to pinnately compound); stipules 0 or generally deciduous
Inflorescence: spike, raceme, panicle, or flowers solitary in axils; bracted
Flower generally bisexual, generally radial, opening at dawn or dusk; hypanthium sometimes prolonged beyond ovary (measured from ovary tip to sepal base); sepals generally 4(27); petals generally 4 (or as many as sepals, rarely 0), often "fading" darker; stamens generally 4 or 8(2), anthers 2-chambered, opening lengthwise, pollen generally interconnected by threads; ovary inferior, chambers generally 4 (sometimes becoming 1), placentas axile or parietal, ovules 1many per chamber, style 1, stigma 4-lobed (or lobes as many as sepals), club-shaped, or hemispheric
Fruit: capsule, loculicidal (sometimes berry or indehiscent and nut-like)
Seeds sometimes winged or hair-tufted
Genera in family: 15 genera, ± 650 species: worldwide, especially w North America; many cultivated (Clarkia, Epilobium, Fuchsia, Gaura, Oenothera )
Reference: [Munz 1965 North America Fl II 5:1278]
Stem generally erect, < 1 m, slender; hairs 0 to dense, rarely glandular
Leaves cauline, alternate (or lowest subopposite), entire, petioled or not, narrow-lanceolate
Inflorescence: flowers axillary, pedicelled or not, opening at dawn
Flower: hypanthium inconspicuous; sepals 4, staying fused in 2's or all coming free; petals 4, 0.58 mm, white, with 12 yellow or greenish spots at base, fading pink or red; stamens 8, those opposite sepals larger, pollen ± yellow; ovary chambers 2, stigma generally not beyond anthers, generally touching them, generally ± spheric
Fruit: capsule, ± cylindric or flat; valves 4, all generally coming free, generally equal
Seeds fewmany, generally all maturing, generally appressed to septum, alternate or subopposite between chambers, in each chamber generally in 1 row and generally not overlapped, 0.52.3 mm, ovoid, glabrous or hairy, brown or gray mottled with brown; appendages 0
Species in genus: ± 9 species: w North America, 2 South America
Etymology: (C. Gay, French author of Flora of Chile, 18001873)
Reference: [Lewis & Szweykowski 1964 Brittonia 16:343391]
Self-compatible; taxa with petals < 3 mm self-pollinated.
Stem < 60 cm; branches at base or not, generally forked above
Leaves 16 cm, generally reduced above
Inflorescence: 1st flower 120 nodes above base
Flower: petals 1.27 mm; larger stamens 0.96 mm; ovary hairy, stigma beyond anthers or not, hemispheric or not
Fruit 315 mm, sessile or generally > pedicel, cylindric, slightly to very knobby
Seeds 318, alternate or subopposite, in each chamber sometimes in 2 rows and overlapped, glabrous to densely puberulent
Chromosomes: 2n=28
Ecology: Common. Open montane forest, sagebrush scrub
Elevation: 8003700 m.
Bioregional distribution: Northwestern California, Cascade Range, Sierra Nevada, Transverse Ranges, Peninsular Ranges, Great Basin Floristic Province
Distribution outside California: w US to British Columbia, Baja California
Complex from several 2n=14 species; subspp. may intergrade locally.
Flower: petals 1.23 mm; larger stamens 0.92 mm; stigma not beyond anthers, ± spheric
Fruit: seeds in each chamber sometimes in 2 rows and overlapped
Ecology: Common.
Habitats, elevations of sp.
Bioregional distribution: Northwestern California, Cascade Range, Sierra Nevada, Transverse Ranges, Peninsular Ranges, Great Basin Floristic Province
Flowering time: MaySep
Variable; most small-flowered plants assigned by Munz, others to G. nuttallii belong here; may occur with any member of genus.


text:
Storm Erik is bringing wet and windy weather conditions to the UK, with various Met Office warnings currently in place.
Named Storm Erik by Met Éireann, the strongest and most damaging winds are expected in the Republic of Ireland, but the Met Office have issued yellow weather warnings to the Northern Ireland and Scotland today (Fri 8 Feb), with the warning extending to parts of northern England early on Saturday.
Disruption expected
Met Office Chief Meteorologist, Will Lang, said, "Southwesterly winds will strengthen across the UK on Friday, so it's going to be a windy day for everyone.
"Across southern parts of the UK, gusts will reach 40mph widely inland, however the strongest winds are expected across Northern Ireland and Scotland, with gusts of 50 to 60mph possible.
"This swathe of strongest winds will spread to parts of northern England early on Saturday morning.
Lang also explained that Storm Erik could bring disruption to the UK, particularly transport, with potential for delays.
"Where the winds are strongest there could be some disruption to transport, with delays and bridge closures possible," he said.
"Large waves are expected across coastal areas where gusts could reach 70mph, possibly affecting coastal routes and sea fronts."
Weather warnings currently in place
A Met Office yellow weather warning for wind is in place until 6pm tonight, covering the Highlands and Eilean Siar, Northern Ireland, south west Scotland, the Lothians, the Borders and Strathclyde.
A second warning for wind is in place tomorrow (9 Feb) from 12:15am until 3pm, covering Central Scotland, Tayside and Fife, the East Midlands, North East England, North West England, Northern Ireland, south west Scotland, the Lothians, the Borders, Strathclyde, Wales, the West Midlands and Yorkshire and the Humber.
"A swathe of very strong westerly winds is expected to move east through Saturday morning, easing from the west during the day," the Met Office said.
"Inland gusts of 55 mph are expected quite widely, with some places having gusts to 70 mph, more particularly around exposed coasts and hills."
A yellow warning for rain is also in place until 3pm tomorrow (9 Feb), covering Central Scotland, Tayside and Fife, the Grampians, the Highlands and Eilean Siar, and Strathclyde.
This article originally appeared on our sister site, The Scotsman


text:
Metroid series lead and co-creator Yoshio Sakamoto teaches us something we never knew we never knew. Intergalactic bounty hunter and Metroid: Other M star Samus Aran's ship—which bears a striking resemblance to her space suit—doesn't have a name.
In the latest issue of Nintendo Power, Sakamoto answers the question "Does Samus's ship have a name?" with the following somewhat disappointing revelation. "We've always just called it 'starship,'" he says. "Some people on the team even call it 'Samus's ship,' but that's not exactly an official term."
How dull! And from a series that introduced us to the memorably named Screw Attack no less!
While Nintendo may not have an official name for Samus Aran's ride of choice—some games have referred to it as Samus' Gunship, still snoozeworthy compared to the Vic Vipers and Millenium Falcons of other universes—it presents a possible challenge. What can we name this thing?


text:
HTML5 and CSS3 Fundamentals Online Courses
HTML5 and CSS3 Fundamentals Online Course in Mozambique
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CSS (Cascading Style Sheets) essentially 'enhances' HTML, giving developers and users more control over how pages and content is displayed. It is responsible for creating more visually engaging web pages, applications and interfaces. CSS3 is the latest version, and has many more extended features than previous versions - although it is backwards compatible.
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Page Not Found
Sorry, the page you are trying to view does not exist. Please modify your request by clicking the back button on your browser or you can try to resolve the problem by:
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Tips and Solutions
Whether it's your first latch or you have been breastfeeding successfully for months, Medela is here to support you with answers to many questions you may have. Whether it's preparing to return...
- Tips and Solutions
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text: HealthAugust 17, 201210 Real Reasons to Lose 10 PoundsDo this one thing and you'll shrink fat cells, have sexier sex and earn more money. We're in!By Jessica Girdwain FacebookTwitterPinterestPinterest1Save Brain PowerWomen scored one point lower on a memory test for every unit higher in body-mass index. Translation: Fat may make you forgetful. Shed that last 10 and chances are you'll stay brilliant.Pinterest2Get FasterFlab's a drag. Literally. For every pound of fat you lose, you run up to 4 seconds faster per mile; with 10 gone, that's up to 40 seconds off your mile time, says Paul Vanderburgh, Ed.D., an exercise physiologist at the University of Dayton. "Your body won't have to work as hard to go forward."Pinterest3Improve Your MoodYou can feel more confident and upbeat by peeling off that tenner. It's enough of a change to raise your body image and energy level; it may even help lift depression.Pinterest4Be Ready for Baby, Whenever"Just a small amount of excess weight may alter pregnancy hormones such as progesterone—which can affect egg quality and prevent ovulation," says Meike Uhler, M.D., a reproductive endocrinologist at Fertility Centers of Illinois in Naperville. If you can't ovulate, you can't get pregnant.Pinterest5Shrink Your Fat CellsYep, you'll actually make the cells smaller. That means a tinier waist and other big payoffs such as a healthier heart—ab flab raises your risk for heart disease.Pinterest6Earn More DoughWomen with excess pounds make nearly $10,000 less per year than their average-weight coworkers. Possibly they are less assertive. (It takes cojones to ask for a raise!) Slim down and you may up your take-charge attitude and your take-home pay.Pinterest7Sex Up Your Sex Life"The biggest benefits in the bedroom come from weight loss and regular exercise. Both put women in touch with their bodies in a positive way, which increases sex drive," says Ronette Kolotkin, Ph.D., a consulting professor at Duke University School of Medicine. "Plus, there's no lingerie sexier than confidence—and a small loss can take you there."Pinterest8Dodge DiabetesYou know that extra pounds can lead to prediabetes (and diabetes!). But shedding 5 to 10 percent of your weight can slash that risk by nearly 60 percent. If you're 150 pounds, a 7.5-pound loss may keep you healthy.Pinterest9Stay Off the SidelinesDownsize yourself and your risk of injury diminishes, too. Every pound of body weight translates to about 4 pounds of force on your ankles, knees and hips when you're walking, so 10 extra pounds on your frame means 40 more pounds of pressure on your joints. Trim down slightly and your joints will suffer less wear and tear.Pinterest10Look Hotter in Jeans"After dropping 10 pounds, I bought my first pair of skinny jeans," says Shelley Senai, 27. "Before, I didn't feel comfortable in anything fitted. Now I love the look."Sign up early for our SELF Diet Club program which will have you losing two pounds every week!SELF does not provide medical advice, diagnosis, or treatment. Any information published on this website or by this brand is not intended as a substitute for medical advice, and you should not take any action before consulting with a healthcare professional.TopicsHealthTipsweight loss


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5/16" Tube Diameter Aviation Clamp - MS21919WDG5
MS21919 Series Clamps
Loop-type cushioned aluminum alloy clamp.
Cushion (non fuel-resistant) is bonded to inner surface and edges of clamp. WDG
clamps are cushion wedge type. Cushion assures tight fit and eliminates vibration,
thus preventing line abrasion
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