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subset: commoncrawl


text:
If Louise Mann had kept her dirty laundry to herself, she might not be where she is today.
One day in late 2007 her washing machine gave out, forcing the mother of two to go in search of a laundromat near her home outside Austin. She discovered a business idea in the process.
"All the places were dirty and dark, and the people inside didn't look happy," recalls Mann. "I started thinking, 'It can't be that hard to make laundromats more inviting.'"
At the time, Mann was a senior regional sales manager at a worldwide temporary-housing provider, but changes in the commission structure there had left her feeling discontented. So she was especially motivated to spend her off-hours developing a business plan for a better laundromat — one that would be clean, bright, and environmentally responsible.
Her store would have planet-friendly features like energy-efficient machines and solar blinds, along with customer conveniences like free Wi-Fi and TV.
Related: Baby on the Way? Time to Make a Budget
She soon shared her idea with a neighbor, a general contractor whose partner had worked in dry cleaning. The three joined forces — and by the end of 2007, Mann had quit her job to work on launching Wash Day Laundry. "When you have a business idea, you just want to jump in and do it overnight," she says.
An equipment vendor helped Mann and her partners find a storefront in a promising location: near several apartment complexes and miles away from the nearest competitor.
While the former liquor store was being retrofitted as a laundromat, Mann began promoting the business through social media, newspaper ads, bilingual fliers, and direct-mail coupons.
Launched in March 2009, Wash Day was an immediate hit: It reaped $275,000 its first year, which motivated the group to open two more laundromats in 2011.
Related: Ace Your Annual Review
"When it's your own business, you don't stagnate," says Mann, who now earns $60,000 a year from the stores. "You learn all the time."
$300,000: Amount she invested.
Most of it went to equipment and renovations for the first store. Mann, who was widowed in 2001, kept her family's living costs low (moving to a smaller home, for example). Since remarrying in 2011, she says, "I now have the safety net of a second income."
51%: Her share of the first store.
Her partners, both men, each claim 24.5%. ("For government contracts, it could help us to be woman-owned," she notes.) She owns 49% of the second unit, and a third of the third, in which she invested $10,000 while her partners put in $30,000.
2015: Year she expects to take home six figures.
The company financed 75% of the equipment for the first unit; once that loan is paid off in 2015, about $12,000 a month drops to the bottom line. With the stores expected to bring in a combined $800,000 by then, Mann thinks her income will reach roughly $100,000, not far off from her old salary of $120,000.


text:
Road Trip Wednesday #126: Prom!
Kody is the NYT bestselling author of The DUFF, Shut Out, and A Midsummer's Nightmare, all from Little Brown/Poppy, as well as Lying Out Loud, Run, and the middle grade novel The Swift Boys and Me, from Scholastic. Born and raised in Kentucky, she now lives in NYC.
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26 comments:
Oh look, and it's a P-word for us A-to-Z Bloggers, too! How considerate of you, Kody! Unfortunately, I went to school in the UK, and we didn't do a prom, so this is something I don't have a lot of experience with... so for the first time in a long time, I'll have to sit this one out. Sorry!ReplyDelete
I grew up in South Africa. We don't have a prom but we do have a bunch of other dances. Here's my storyReplyDelete
OK, so I had a Hermione moment. All will be explained in my contribution. :)ReplyDelete
Here's my prom story: http://bricarter.blogspot.ca/2012/04/road-trip-wednesday-one-more-time-were.html :)ReplyDelete
Yes yes yes! Here's mine.ReplyDelete
Wish I lived in a teen movie for this one. Oh well, here's mine:ReplyDelete
Oh my gosh, that picture! The vest! And the hat! I love that guy for going all out, that's awesome.ReplyDelete
My boyfriend for prom wore a silver satin suit his mom made to match my dress. And he wore patent leather skater shoes - Airwalk sneakers I think. I think four other guys borrowed that suit over the next few years. I'm all for trying something different, even if it's more funny than cool looking back on it.
This comment has been removed by the author.ReplyDelete
Here's mine! http://www.tarynalbright.com/2012/04/rtw-prom.htmlReplyDelete
Yay! I cannot wait to read all those posts! I didn´t go to prom but I still got lucky!ReplyDelete
This question is so nostalgic! Here's mine!ReplyDelete
Prom?! Ugh. Okay - click here for all the sordid details.ReplyDelete
The Prom!ReplyDelete
here's mine:
Oh, Prom...ReplyDelete
Here's mine!ReplyDelete
Oh no, I totally have nothing for this one--never went to a prom, despite attending three high schools. Maybe those are related; was never at a school long enough for me to get asked. It probably didn't help that I only went to school 1-2 days a week!ReplyDelete
Perhaps someone intended to ask me but couldn't find me? Yeah, I'm going with that.
Here is my storyReplyDelete
Prom ahoy! http://readingontheftrain.blogspot.com/2012/04/prom-shockingly-not-most-important.htmlReplyDelete
Here's my post:ReplyDelete
I effin loved prom:ReplyDelete
Late to the party today! :)ReplyDelete
Here's mine.
I never went to either of my proms. So I have no story to tell.ReplyDelete
Because I really needed to share photos from my Awkward Teenage Years with the entire internet.ReplyDelete
Here's mine :)ReplyDelete


text:
Here We Go Again: Corrupt PA Judges Not Tagged As Dems
Mark Ciavarella and Michael Conahan are Democrats. Is it okay to write that? Apparently, it's not in an establishment media report, based on the last six months of coverage of these two corrupt Pennsylvania judges.
In February (at NewsBusters; at BizzyBlog), I noted that the Associated Press ran a story about two Pennsylvania judges "charged with taking millions of dollars in kickbacks to send teenagers to two privately run youth detention centers," and and initially told readers that "Both are Democrats."
But AP removed the judges' party affiliation from a subsequent version of the story (graphic proof comes later in the post), even though the later rendition added many other details in the case. This of course begged the question of why AP did what they did, especially since the wire service's Stylebook says the following about identifying party affiliation:
party affiliation Let relevance be the guide in determining whether to include a political figure's party affiliation in a story. Party affiliation is pointless in some stories, such as an account of a governor accepting a button from a poster child. It will occur naturally in many political stories. For stories between these extremes, include party affiliation if readers need it for understanding or are likely to be curious about what it is.
The idea that readers, especially those outside of Pennsylvania, would not be curious about the political affiliations of former judges Ciavarella and Conahan is absurd on its face.
Since that initial journalistic failure, there has been a media wall of silence about the party affiliations of the two men:
- A July 31 AP story (covered at NewsBusters; at BizzyBlog) continued the see-no-Democrats story.
- The July 27 New York Times ran a story (HT Reason's Hit & Run) about how many of the 6,500 juveniles detained — many if not most unjustly, based on their offenses and criminal histories — were on the verge of having their records destroyed, hampering their ability to pursue litigation over their treatment. No mention of the two former judges' party appeared.
- Last week, the local area TimesLeader.com (HT to Reason, again) ran a story about how the judges were withdrawing their guilty pleas. The judge overseeing their case has not been seeing a lot of remorse from the two disgraced men, or even any willingness to completely admit to the facts of what they did, and thus has been refusing to accept their proposal for seven-year sentences. Though you might argue that a local story carries no party-ID requirement because people in the area supposedly know it already (doubtful, in my opinion), the men were not ID'd as Dems.
- The Associated Press story doesn't have the local-reader excuse available. A brief story that went over the AP's national wire did not identify Ciavarella or Conahan as Democrats.
Here's the original graphic comparison of the initial and subsequent AP reports:
As I have noted in previous posts — "The red box on the left shows where the story as carried at Topix identified the two judges as Democrats; at the time, it was the only place I found the identifying sentence. The red box at the right shows a paragraph that was added later by AP at the MSNBC link; the 'Both are Democrats' sentence originally in the previous paragraph is gone. No form of the word [Democrat' appeared in the revised story at MSNBC; that is still true today. The green boxes show that the specific story linked by Topix is indeed the MSNBC story on the right."
The first decision to identify the party of the two cretins was the right one. Every call since, at least among those I have seen (including Reason's) has been wrong. It is highly doubtful, if the judges had been Republicans, that the press would be so accommodating as to hide their party affiliations so consistently and for such a long period of time — especially after initially spilling the beans.
Cross-posted at NewsBusters.org.


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|Series :
|Rating :
|Disc No :
|Episode :
|First Aired :
|19 Nov 2004
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|Director :
|Michael Grossman
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|Garfield Reeves-Stevens, Judith Reeves-Stevens
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|Why doesn't T'Pau talk anything like she did in TOS? Then she was all "art thou Human, Spock?" Now she talks perfectly normal English.
Soval says that Vulcans are worried about how fast Humans are advancing because it took his people 1,500 years to recover and travel to the stars after their wars. Later on they say Surak lived 1,800 years ago. So Vulcan made it into space about 300 years ago. So... how did they found the P'Jem monastery 3,000 years ago, as claimed in "The Andorian Incident"?
|Great Moment :
|Manny Coto is fixing the Vulcans!
|Body Count :
|43 people died in the bombing - 12 Vulcans and 31 Humans, including Admiral Forrest. Syrran died as a result of the fire storm.
|Factoid :
|Again a lot of nice continuity in this episode. Establishment of Katras and the use of mind melds to transfer them between people, as seen in Star Trek II/III - Syrran even uses the "remember" line when transferring Surak's Katra to Archer, just as Spock did when transferring his to McCoy, though he did it in Vulcan.
We see a Sehlat, and learn that T'Pol had one as a pet when she was young, just as Spock mentioned that he had in "Journey to Babel".
We get mention of the Vulcan inner eyelid which protects against high intensity light, as mentioned in "Operation : Annihilate".
We learn a new fact about Vulcans - they need only drink once every several days. Although this was not officially established in TOS, it was extremely rare to see Spock or any other Vulcan drink anything during that series.
Another nice inter-series link - the T'Karath Sanctuary where the Vulcan rebels are hiding is the same place where Picard and the mercenaries beamed down with the psionic resonator in TNG's "Gambit, Part 2". Incredibly, a line of dialogue in the TNG episode even states that the caves were used by one of the factions in the last civil war, centuries ago! A truly amazing bit of continuity there!
Both the questions Archer is asked are directly from the computer test Spock took in "Star Trek IV". The answers are "Logic is the cement of our civilization with which we ascend from chaos, using reason as our guide" was said by T'plana-Hath, Matron of Vulcan philosophy; and Kiri-kin-tha's First Law of Metaphysics is "Nothing unreal exists". And yes, I knew both of these without having to look them up.
However, Coto is going further that this. Not only is he stacking fun facts into his episodes, he is actually going out of his way to re-write Enterprise's previous sins! One of the most irritating and even outright offensive features of Enterprise to date has been the "evil Vulcan syndrome" which I've mentioned a few times now and which culminated in the episode "Stigma". In that episode we learned that the Vulcan government was so obsessed with hating those who practiced mind melds that it was willing to allow them to die off from a disease which was being spread through the practice - essentially practicing a form of eugenics. It was a truly horrific thing to depict the Vulcans as doing, and although the episode was actually well intentioned (it was an analogy of the attitude that some people display towards HIV/AIDS today), it left a terrible taste in my mouth. You couldn't look at the peaceful, civilised species which valued "infinite diversity in infinite combinations" we saw in TOS and picture them as being the same people we saw in "Stigma".
Clearly, Coto thought along much the same lines. This arc seems to be dedicated in large part not only to explaining that discrepancy, but to actually showing us at least some of the transition from "evil" to "good" Vulcans. You can't imagine that Berman and Braga would ever have even thought of trying something like this; Coto is not only doing it, he's doing it well. It's a major achievement that deserves a lot of kudos.
So the episode has excellent intentions. How well does it fulfil them? Very well, I think. Everybody is acting in character and the plot hangs together well, with no obvious gaps in logic, or at least none that sprang out at me. It's not the most fast-paced or exciting of episodes, with what little action or danger there is having to be manufactured out of natural threats like the Sehlat and the fire storm, but it's none the worse for that - Vulcan has long been one of the more mysterious of Trek planets, and it's nice to learn a little more about it. Having Archer pick up Surak's katra is an interesting development, and I'm looking forward to seeing where they are planning to go with that.
All in all The Forge is an interesting episode which delivers a lot whilst promising even more for the future. I heartily enjoyed it.
|Copyright Graham Kennedy
|Page views : 26,667
|Last updated : 27 Apr 2005


text: We offer a full range of lab testing services. Test results are immediately transmitted to your physician's office. Patients may also have specimens collected and tested here and the results sent to a specialist in another city. In addition to routine lab tests most often requested by your physician, we also offer health screens to promote wellness and reduce health risks in our community.


text:
Compliance with the National Electrical Code is a major concern for today's engineers, designers and electricians. On the one hand, you need to keep job costs down. On the other hand, your electrical projects must meet code. And if you are an electrical inspector, you've got to ensure compliance with the code in a way that is fair, accurate, equitable, and consistent. The need to understand and accurately apply the NEC is great. But, the NEC is huge—the loose-leaf binder version, for example, is nearly 800 pages. Complicating this further, the NEC can be downright confusing. Even common applications make NEC training essential. For example, consider those tables in Article 310. Do you really understand how to size conductors? Do you understand when to use the 90 degree column and when not to? Do you know when to use Table 310.17 rather than 310.16, or 310.19 rather than 310.17? How do you apply these tables when sizing feeders for motor circuits? What about motor branch circuits? A wrong answer to any of these questions can be costly. How can you make sure you get this right? How will you ever rise above the confusion? Fortunately, there's an answer. And it's from internationally recognized NEC expert Mike Holt. That answer is Mike Holt's Illustrated Guide to Understanding the National Electrical Code, Volume 1. This resource has proven itself in the field and in the exam room. And now you can rely on the latest edition to provide you with the rock-solid foundation of NEC knowledge you need to do your job with accuracy and confidence. Some highlights of what's you will understand after using this outstanding resource:
This textbook covers the following topics: •Air-Conditioning and Refrigeration Equipment •Appliances •Armored Cable (Type AC) •Branch Circuits •Branch-Circuit, Feeder, and Service Calculations •Cabinets, Cutout Boxes, and Meter Socket Enclosures •Cable Trays •Capacitors •Conductors For General Wiring •Conduit Bodies •Definitions •Electrical Metallic Tubing •Electrical Nonmetallic Tubing •Feeders •Fixed Electric Space-Heating Equipment •Fixture Wires •Flexible Cords and Flexible Cables •Flexible Metal Conduit •Generators •Grounding and Bonding •Handhole Enclosures •High-Density Polyethylene Conduit •Inter ...
More Information
Product Code: 08UND1
Pages: 505
Illustrations: 1010
Practice Questions: 393
$59.00 $10.00


text:
Bachelor of Science in Interdisciplinary Studies (code 3-0405)
This new degree was recommended by the Academic Senate on February 4, 1999, concurred by the President on March 23, 1999 and approved by the Office of the Chancellor on June 25, 1999.
The Interdisciplinary Studies major for the bachelor of science degree allows selected students to engage in an individualized baccalaureate program when legitimate academic and/or professional goals cannot be accommodated by existing academic programs or combinations of such programs (i.e., majors, minors, certificates). The Interdisciplinary Studies major adheres strictly to the University's mission statement and consists of a closely correlated program of study in two or more departments developed in conference with faculty members from the respective departments who have the academic and professional expertise necessary to support the individualized course of study.
The Interdisciplinary Studies major is not a means of bypassing normal graduation requirements nor a means by which students may seek to graduate who have failed to gain admission to impacted programs or to complete a degree major in which they are currently enrolled. Consequently, a candidate must apply for approval of an Interdisciplinary Studies major when:
1. At least one full year of academic work (30 units) remains to be
completed to meet minimum graduation requirements.
2. At least 2/3 of the upper-division (300-400) units in the proposed
course of study remain to be completed at the time the application is
submitted for approval.
3. The GPA in the current major is 3.0 or better. Exceptions to this
rule will be made on a case-by-case basis.
The Interdisciplinary Studies program of study must be justified by legitimate career, academic, and /or professional goals commensurate with the broader mission of the University in baccalaureate education. Interdisciplinary Study majors are considered on a case-by-case basis. Approval is determined on the basis of the academic merit of the proposed course of study, the proposal rationale, the applicant's potential for successful completion of the program, and on the ability of the University to support the proposed program. Goals should be carefully reviewed before proceeding with an Interdisciplinary Studies major.
1. To prepare for the initial interview:
A. Make an appointment with the Interdisciplinary Studies Director
to discuss eligibility for the program.
B. Prepare a written proposal, eight pages in length, identifying
your educational goals and objectives, your career goals and
objectives; explaining why these cannot be met through an existing
major; and listing the courses at CSULB appropriate to your goals.
2. Present your written statement for initial review to the
Interdisciplinary Studies Director from whom guidelines,
recommendations, and forms necessary for the following steps may be
obtained if the proposal is determined to be promising.
3. Seek out a faculty advisor from each discipline in which substantive
course work will be undertaken. These faculty must have the expertise
appropriate to the Interdisciplinary Study you propose, must find merit
in your proposal, must agree to meet with you and all other faculty
adviser to develop a program of study, and must agree to continue to
act as your program advisors.
4. Arrange a meeting of the faculty advisors for the purpose of
developing the list of specific courses that will constitute the
Interdisciplinary Studies degree program. Any modification of this
program after it has been officially approved by the Interdisciplinary
Studies Director requires the concurrence of all faculty advisors and
must be the result of consultation with them, usually at an advisory
meeting. Faculty advisors sign the official Interdisciplinary Studies
Major Program form and any subsequent Program Addendum forms.
5. Submit the Interdisciplinary Studies Major Program, signed by the
faculty advisors, to the departmental chairs of each department in
which substantive work is projected. Their signatures on your program
form indicate they have reviewed its contents, approved the proposed
program, and are granting you the same priority status for enrollment
in courses in their departments as that accorded departmental majors.
6. Return your program with all signatures to the Interdisciplinary
Studies Director along with your typed Interdisciplinary Studies
proposal and transcripts from all schools attended, including a current
set of transcripts from CSULB. Completed programs must be approved by
the Interdisciplinary Studies Program Director and will be filed in the
Interdisciplinary Studies Office and the Records Office. Be advised
that pending final approval of your Interdisciplinary Studies Program
you should proceed with the course work for your previously declared
major or with General Education and elective courses. You should delay
taking courses that will count only toward the fulfillment of your
Interdisciplinary Studies Program until the semester following formal
admission into the major.
1. An Interdisciplinary Studies Program consists of a maximum of four
lower-division courses (100-200) and a of a minimum of 36 units of
upper-division courses (300-400) totalling a minimum of 48 units in the
2. An Interdisciplinary Studies Program is based on a thematically
cohesive core of classes involving significant work in more than two
disciplines. A rationale must accompany the program and be signed by
the faculty advisors when the program is submitted to the
Interdisciplinary Studies Program Director for approval.
3. Interdisciplinary courses (1) taken to satisfy General Education
requirements may be double-counted to meet Interdisciplinary Studies
Program unit requirements, if the program consists of more than 48
units of credit.
EFFECTIVE: Fall 1999
Code: 3-0405
College: 94
Career: UG
IPEDS (Major) ERSS: 49993
IPEDS (Degree) ERSD: 49993


text:
|February, 2010
|Seguin et al.
|Device to promote blood flow into the myocardium
|December, 2004
|System and Method for Restoration of Nutrient Flow to Nucleus Pulposa
|September, 2008
|Matsuura et al.
|Exclusion Device and System For Delivery
|December, 2007
|Vascular Stent and Method of Making Vascular Stent
|December, 2008
|Craven et al.
|Male urethral prosthesis
|October, 2004
|Siegel et al.
|Implantable medical devices made from polymer-bioceramic composite
|December, 2007
|Wang et al.
|April, 2010
|Flexible stent with torque-absorbing connectors
|November, 2008
|Method for inserting a spinal fixation element using implants having guide tabs
|September, 2009
|Dziedzic et al.
|Apparatus and Method for Hip Cup Extraction
|August, 2008
This invention relates to endoprosthesis devices, generally called stents, and more particularly, to achieving desired visibility of such devices under magnetic resonance imaging (MRI), computer tomography, and fluoroscopy.
Stents are generally thin walled tubular-shaped devices composed of complex patterns of interconnecting struts which function to hold open a segment of a blood vessel or other body lumen such as a coronary artery. They also are suitable for supporting a dissected arterial lining or intimal flap that can occlude a vessel lumen. At present, there are numerous commercial stents being marketed throughout the world. These devices are typically implanted by use of a catheter which is inserted at an easily accessible location and then advanced through the vasculature to the deployment site. The stent is initially maintained in a radially compressed or collapsed state to enable it to be maneuvered through the lumen. Once in position, the stent is deployed. In the case of balloon expandable stents, deployment is achieved by inflation of a balloon about which the stent is carried on a stent-delivery catheter.
The stent must be able to simultaneously satisfy a number of mechanical requirements. First, the stent must be capable of withstanding the structural loads, namely radial compressive forces, imposed on the stent as it supports the walls of a vessel lumen. In addition to having adequate radial strength or more accurately, hoop strength, the stent should be longitudinally flexible to allow it to be maneuvered through a tortuous vascular path and to enable it to conform to a deployment site that may not be linear or may be subject to flexure. The material from which the stent is constructed must allow the stent to undergo expansion which typically requires substantial deformation of localized portions of the stent structure. Once expanded, the stent must maintain its size and shape throughout its service life despite the various forces that may come to bear thereon, including the cyclic loading induced by the beating heart. Finally, the stent must be biocompatible so as not to trigger any adverse vascular responses.
In addition to meeting the mechanical requirements described above, there is a requirement that a stent be radiopaque or fluoroscopically visible under x-rays. Accurate stent placement requires real time visualization to allow the cardiologist or interventional radiologist to track the delivery catheter through the patient=s vasculature and precisely place the stent at the site of a lesion. This is typically accomplished by fluoroscopy or similar x-ray visualization procedures. For a stent to be fluoroscopically visible it must be more absorptive of x-rays than the surrounding tissue. This is typically accomplished by the use of radiopaque materials in the construction of a stent, which allows for its direct visualization. The most common materials used to fabricate stents are stainless steel and nickel-titanium alloys, both of which are radiopaque. This factor, in combination with the radial wall thickness of about 0.002 to 0.009 inch of most stent patterns, renders stents produced from these materials sufficiently radiopaque to be optimally visualized with x-ray based fluoroscopy procedures. Although both materials are generally regarded as being bio-compatible, some recent concerns have arisen regarding the long term biocompatibility of stainless steel. Over time, nickel, a constituent element of most stainless steels, tends to leach from a stainless steel stent. In addition, the chromium oxide layer present on the surface of stainless steel stents to prevent corrosion may have a tendency to degrade during long term use within the body.
Alternative, non-toxic, high density metals, such as cobalt-chromium, tantalum, iridium, platinum, gold, and the like, have been used in prior art stents. However, these alloys can sometimes either be excessively radiopaque or may lack sufficient strength for recoil, radial strength requirements, and long-term use in a dynamic vascular setting. Stents constructed of highly radiopaque materials appear overly bright when viewed under a fluoroscope. This tends to overwhelm the image of the tissue surrounding the stent and obscures visualization of the stent lumen. Due to the lack of an appropriately radiopaque material, simply constructing a stent wholly out of a single material has heretofore not resulted in a stent with the optimal combination of mechanical properties and radiopacity. Thus, the art has moved in the direction of combining different materials to produce a mechanically sound, biocompatible and fluoroscopically visible stent. A number of such approaches have been developed. Typically such methods have focused on increasing the radiopacity or fluoroscopic visibility of stainless steel and nickel-titanium alloy stents.
One means frequently described for increasing fluoroscopic visibility is the physical attachment of radiopaque markers to the stent. Conventional radiopaque markers, however, have a number of limitations. Upon attachment to a stent, such markers may project from the surface of the stent, thereby comprising a departure from the ideal profile of the stent. Depending on their specific location, the marker may either project inwardly to disrupt blood flow or outwardly to traumatize the walls of the blood vessel. Additionally, galvanic corrosion may result from the contact of two disparate metals, i.e., the metal used in the construction of the stent and the radiopaque metal of the marker. Such corrosion could eventually cause the marker to separate from the stent which may be problematic should the marker be swept downstream within a vessel. Discrete stent markers cannot show the entire outline of the stent which is a preferred method to determine the optimal expansion of a stent over its entire length.
The radiopacity of stents has also been increased by plating or coating selected portions thereof with radiopaque material. However, a number of disadvantages are associated with this approach as well. When the stent is expanded certain portions undergo substantial deformation, creating a risk that cracks may form in the plating or coating causing portions of the plating to separate from the underlying substrate. This has the potential for creating jagged edges that may inflict physical trauma on the lumen wall tissue or cause turbulence in the blood flowing past the stent, thereby inducing thrombogenesis. Moreover, once the underlying structural material becomes exposed to an electrolytic solution such as blood, interfaces between the two disparate metals become subject to galvanic corrosion. Over time, galvanic corrosion may also lead to separation of the plated material from the underlying substrate.
X-ray based fluoroscopy is the current preferred modality for imaging stents during an intervention and for diagnostic assessment. However, in addition to the potential disadvantages stated above, other drawbacks may exist. Exposure to ionizing radiation and nephrotoxic iodinated contrast agents are intrinsic to the technique, as well as the need to wear leaded personal protective equipment. Alternatively, magnetic resonance imaging (MRI), produced by complex interactions of magnetic and radio-frequency fields, does not suffer from these drawbacks and is actively being pursued to image stents in a diagnostic mode and, in the future, to guide stent based interventions. MRI has gained an increasing role in the diagnosis and assessment of human pathology. In patients undergoing MRI, there are numerous devices which are poorly seen, if they are visible at all, on the MR image artifact. The location and course of these implanted devices is usually of great clinical importance to assure their proper function and avoid complications that malposition can cause.
Due to their small size, current metal stents are sometimes difficult to see in fluoroscopy as they attenuate the x-ray beam very little. This is particularly true in very large, obese patients being imaged in lower end grade imaging systems. In MRI, the problem is that ferromagnetic and metallic based stents are difficult to see as they can create a large imaging artifact (a region of signal void or diminishment, which can extend beyond the stent boundaries). A plastic medical device, namely a polymeric stent, is particularly better for MRI as it is non-ferromagnetic and non-metallic. Indeed, a polymeric stent produces substantially no artifact at all. The signal used in most conventionally available MRI comes from the nuclear magnetic resonance of hydrogen nuclei. Polymers contain hydrogen atoms but these nuclei resonate at a frequency which is shifted from the water hydrogen signal from which the image is mainly derived. Moreover, the emitted RF signal from, polymers is quite broad. Under MRI, polymers appear as a region of signal void that is the same size as the device and therefore, more clinically accurate. Unfortunately, this creates a situation analogous to fluoroscopy with a stent that is difficult to visualize. A solution to imaging a polymeric stent under MRI is to add a substance to the polymer to change its magnetic susceptibility. These materials are well known to those skilled in the art and consist of paramagnetic or ferromagnetic compounds, particles and fillers. By the choice of agent, and its concentration in the polymer, the size of the susceptibility artifact can be tuned.
Fluoroscopy generates a two-dimensional projection image of what are three-dimensional structures. This requires multiple views to appraise complex vasculature. Another imaging modality, which has the potential to supplant fluoroscopy and become important in the diagnostic imaging of stents, is magnetic resonance imaging (MRI). One advantage of MRI is that it is a tomographic imaging technique that generates a 3-D data set of the imaged tissue. Consequently, the data set can be manipulated to show different imaging planes and slice thicknesses. This permits high quality transverse, coronal and sagittal images to be obtained directly. MRI has greater soft tissue contrast and tissue discrimination than computed tomography (CT) or other x-ray based imaging modalities, such as angiography. As another advantage, MRI also does not use ionizing radiation and does not require catheterization to image the vasculature.
The technique of MRI encompasses the detection of certain atomic nuclei (those possessing magnetic dipole moments) utilizing magnetic fields and radio-frequency (RF) radiation. It is similar in some respects to x-ray computed tomography in providing a cross-sectional display of the body organ anatomy, only with excellent resolution of soft tissue detail. In its current use, the images constitute a distribution map of protons, and their properties, in organs and tissues. However, unlike x-ray computer tomography, MRI does not use ionizing radiation. The fundamental lack of any known hazard associated with the level of the magnetic and radio-frequency fields that are employed renders it possible to make repeated scans. Additionally, any scan plane can readily be selected, including transverse, coronal, and sagittal sections. MRI is, therefore, a safe non-invasive technique for medical imaging.
The hydrogen atom, having a nucleus consisting of a single unpaired proton, has one of the strongest magnetic dipole moments of nuclei found in biological tissues. Since hydrogen occurs in both water and lipids, it is abundant in the human body. Therefore, MRI is most commonly used to produce images based upon the distribution density of protons and/or the relaxation times of protons in organs and tissues. The majority of the signal in MRI comes from water. Tissues vary in their water content, but for angiography, blood is the relevant tissue. Blood is approximately 93% water. This translates into a proton concentration of 103 moles/liter. However, MRI can image tissues with a lower water content. For example, grey matter and bone are 71% and 12% water respectively. It must be noted that MRI can image proton concentrations much lower than those of blood or grey matter. Image resolution is determined by the signal to noise (S/N) ratio. Faster acquisition of data or longer acquisition times both increase the signal to noise ratio.
MRI is presently used for diagnostic applications, but interventional MRI is an active area of research. For devices to be seen under MRI, they must be MRI A compatible. @ In the context of a diagnostic or interventional procedure, this refers to the ability to accurately image a stent. MRI imaging schemes for devices are divided into two categories, active and passive. Active imaging requires some sort of electrical circuit on, or electrical connection to, the device. This presently is not an easily implemented solution for small, free-standing devices such as stents. The passive imaging scheme that applies readily to metal stents is based on the stent material=s magnetic susceptibility and electrical conductivity.
Because stents are constructed of electrically conductive materials, they suffer from a Faraday Cage effect when used with MRI=s. Generically, a Faraday Cage is a box, cage, or array of electrically conductive material intended to shield its contents from electromagnetic radiation. The effectiveness of a Faraday Cage depends on the wave length of the radiation, the size of the mesh in the cage, the conductivity of the cage material, its thickness, and other variables. Stents do act as Faraday Cages in that they screen the stent lumen from the incident RF pulses of the MRI scanner. This prevents the proton spins of water molecules in the stent lumen from being flipped or excited. Consequently, the desired signal from the stent lumen is reduced by this diminution in excitation. Furthermore, the stent Faraday Cage likely impedes the escape of whatever signal is generated in the lumen. The stent=s high magnetic susceptibility, however, perturbs the magnetic field in the vicinity of the implant. This alters the resonance condition of protons in the vicinity, thus leading to intravoxel dephasing with an attendant loss of signal. The net result with current metallic stents, most of which are stainless steel, is a signal void in the MRI images. Other metallic stents, such as those made from Nitinol, also have considerable signal loss in the stent lumen due to a combination of Faraday Cage and magnetic susceptibility effects.
At this time, MRI is being used to non-invasively image many regions of the vasculature. The comprehensive cardiac MRI exam has demonstrated clinical utility in the areas of overall cardiac function, myocardial wall motion, and myocardial perfusion. It may become the standard diagnostic tool for heart disease. With these advances in imaging technologies, a stent that can be meaningfully imaged by MRI in an optimal manner would be advantageous. A non-metallic stent obviously solves the imaging problem. Metals, however, are the preferred material as they make strong, low profile stents possible. Unfortunately, most metal stents, particularly of stainless steel, obliterate MRI images of the anatomy in their vicinity and obscure the stent lumen in the image. By reducing the amount of metal in the stent, or by making the cells larger, or by having fewer cells, the Faraday Cage effect may be reduced. The RF radiation used in MRI has a wavelength of 2 to 35 meters depending on the scanner and environment of the stent. Therefore, the cell sizes of stents are already much smaller than the RF wavelength. Increasing the stent cell size would work only primarily by decreasing the amount of metal. This solution is limited by the need for stents to have adequate radial strength and scaffolding.
MRI will not suddenly replace x-ray based fluoroscopy. Being new to the cardiology and interventional fields, and being an expensive technology, MRI utilization and implementation will vary by medical specialty, medical institution, and even on a country by country basis. Therefore, it seems likely that any stent produced for commercialization would ideally be imageable by both fluoroscopy and MRI. Although the paramagnetic or ferromagnetic compounds added for MRI visibility will increase the radiopacity of the polymer, it is not necessarily the case that a single concentration, of a single material, will give ideal visibility in both modalities.
However, MRI has the potential to supplant, and potentially substitute for fluoroscopy in the future. Stents which are more compatible with this imaging modality, or which have a dual functionality, may have a clinical performance benefit. Both the future of stent materials, and the imaging modalities used to visualize them are areas of intense research due to the clinical value and large market for stents, particularly coronary stents. Although metal alloy stents currently dominate the marketplace, polymer stents have potential advantages in the areas of hemocompatibility, biodegradability, and drug delivery.
What is needed therefore is a stent that overcomes the shortcomings inherent in previously known devices. Preferably, such a stent would be formed of a hybrid material, possess the required mechanical characteristics, and also be readily visible using MRI, computer tomography, and x-ray based fluoroscopy procedures.
The present invention is directed to a stent that overcomes the shortcomings of previously known devices by embodying a polymeric material combined with a metallic material to improve visibility under MRI, computer tomography and fluoroscopy.
In one embodiment of the stent of the present invention, metallic rings are positioned between an outer layer of a first polymeric material and an inner layer of a second polymeric material. In other words, the metallic rings are sandwiched in between the first and second polymeric materials. The rings are connected by links which are formed by the first and second polymeric materials. The metallic rings generally are visible under fluoroscopy while the polymeric material provides good visibility using MRI.
The first and second polymeric materials can be taken from a group of polymeric materials which includes polyetheretherketone (PEEK), ethyl vinyl alcohol (EVOH), polyetherketone, polymethylmethacrylate, polycarbonate, polyphenylenesulfide, polyphenylene, polyvinylfluoride, polyvinylidene fluoride, polypropylene, polyethylene, poly(vinylidene fluoride-co-hexafluoropropylene), poly(ethylene-co-hexafluoropropylene), poly(tetrafluoroethyelene-co-hexafluoropropylene), poly(tetrafluoroethyelene-co-ethylene), polyethyleneterephthalate, polyimides and polyetherimide. Other polymeric materials that could be used to form the inner or outer polymeric material include ePTFE, polyurethanes, polyetherurethanes, polyesterurethanes, silicone, thermoplastic elastomer (e.g. C-flex), polyether-amide thermoplastic elastomer (e.g., Pebax), fluoroelastomers, fluorosilicone elastomer, styrene-butadiene-styrene rubber, styrene-isoprene-styrene rubber, polybutadiene, polyisoprene, neoprene, ethylene-propylene elastomer, chlorosulfonated polyethylene elastomer, butyl rubber, polysulfide elastomer, polyacrylate elastomer, nitrile rubber, a family of elastomers composed of styrene, ethylene, propylene, aliphatic polycarbonate polyurethane, polymers augmented with antioxidants, polymers augmented with image enhancing materials, polymers having a proton (H+) core, butadiene and isoprene (e.g., Kraton) and polyester thermoplastic elastomer (e.g., Hytrel) and a di-block co-polymer of PET and caprolactone. For strength, the polymer may further contain reinforcements such as glass fiber, carbon fiber, Spectra™, or Kevlar™.
The metallic rings of each of the embodiments of the present invention are formed from materials that are visible under fluoroscopy, such as metallic alloys. The metallic alloys can be self-expanding or balloon expandable and can include stainless steel, titanium, nickel-titanium, tantalum, cobalt-chromium, and the like.
In another embodiment, in order to provide higher visibility under fluoroscopy, the polymeric materials are compounded with an appropriate radiopacifier such as the powder of barium sulfate, bismuth subcarbonate, bismuth trioxide, bismuth oxychloride, tungsten, tantalum, iridium, gold, or other dense metal. To define a biodegradable structure, the polymeric materials are compounded with a biodegradable radiopacifier that renders it visible under fluoroscopy and can be safely released in the body. Such radiopacifiers include particles of an iodinated contrast agent and bismuth salts.
The first and second polymeric materials also can be formed of self-expanding polymers including shape memory polymers such as oligo (e-caprolactone), dimethylacrelate, and n-butyl acrylate.
Each embodiment of the present invention also can include a therapeutic drug or therapeutic agent associated with the first and second polymeric materials. For example, one or more therapeutic drugs can be loaded into either or both of the first and second polymeric materials to prevent or reduce the likelihood of restenosis or to otherwise treat the vessel or artery.
The hybrid stent of the present invention can be made in several ways. In one embodiment, the metallic rings are cut by a laser using conventional laser cutting procedures. The rings are then mounted on an inner polymeric tube which has been premounted on a teflon mandrel. After the rings have been mounted and positioned on the inner polymeric tube, an outer polymeric tube is mounted over the metallic rings and the inner polymeric tube. A shrink tubing is then mounted over the outer polymeric tube and it is subjected to laser bonding so that the shrink tubing contracts and applies pressure to the outer polymeric tube causing it to compress against the metallic rings and the inner polymeric tube. Further, heat from the laser causes the outer and inner polymeric tubes to partially melt and fuse together. An appropriate bonding agent can be used to help adhere the inner and outer tubes together. The shrink tubing and the supporting teflon mandrel are removed and the stent pattern is then formed by a laser to remove unwanted portions of the polymer material, so that a pattern of metallic rings encased by the polymer material are attached to each other by polymeric links as previously disclosed.
In another embodiment to make the hybrid stent of the present invention, a mandrel is first dip coated into a polymer which corresponds to the inner polymeric material. The metallic rings, which previously were laser cut from a tube, are mounted on the inner polymer material and positioned to form the stent pattern. The outer layer or outer polymer material is deposited over the metal rings either by spray coating or by dip coating the outer polymeric material over the rings and the inner polymeric material. The mandrel is removed and the unwanted portions of the polymers can be machined by using laser cutting as previously described.
It is to be recognized that the stent of the present invention can be self-expanding or balloon-expanded. Moreover, the present invention can be modified to be used in other body lumens including highly tortuous and distal vasculature.
These and other features and advantages of the present invention will become apparent from the following detailed description, which when taken in conjunction with the accompanying drawings, illustrate by way of example the principles of the invention.
FIG. 1 is an elevation view, partially in section, of the balloon-expandable hybrid stent of the invention mounted on a rapid-exchange delivery catheter and positioned within an artery.
FIG. 2 is an elevation view, partially in section, similar to that shown in FIG. 1, wherein the hybrid stent is expanded within the artery so that the stent embeds within the arterial wall.
FIG. 3 is an elevation view, partially in section, showing the expanded hybrid stent implanted within the artery after withdrawal of the rapid-exchange delivery catheter.
FIG. 4A is a plan view of a flattened stent which illustrates the pattern of the hybrid stent shown in FIGS. 1-3.
FIG. 4B is a plan view of a flattened stent which illustrates the hybrid stent with some straight polymeric links.
FIG. 4C is a cross-sectional view taken along lines 4C-4C depicting the hybrid strut in one of the stent rings.
FIG. 4D is a cross-sectional view taken along lines 4D-4D depicting a polymer link.
FIG. 4E is a cross-sectional view taken along lines 4E-4E depicting a polymer link having a cavity containing a therapeutic drug or agent.
FIG. 5 is a perspective view of a pre-expanded balloon expandable hybrid stent depicting the cylindrical wall defined by the cylindrical rings.
FIG. 6 is an enlarged sectional view of FIG. 4 depicting a W-shaped portion of a cylindrical ring.
FIG. 7 is an enlarged sectional view of FIG. 4 depicting several U-shaped or undulating peaks of a cylindrical ring.
FIG. 8 is an enlarged sectional view of FIG. 4 depicting a Y-shaped portion of the cylindrical ring.
FIG. 9 is a plan view of the hybrid stent in a flattened and expanded condition.
FIG. 10 is a typical stress-strain curve for a superelastic material.
FIG. 11 is a longitudinal cross-sectional view depicting the metallic rings and polymer materials being formed on a mandrel.
FIG. 12 is a longitudinal cross-sectional view depicting the metallic rings and polymer materials being formed on a mandrel and the unwanted portions being removed by a laser.
FIG. 13 is a longitudinal cross-sectional view depicting the metallic rings and polymer materials being formed on a mandrel and the unwanted portions being removed by a laser.
The hybrid stent of the present invention combines the features and advantages of metallic stents with those of polymeric stents so that the combined hybrid stent provides the required structural support for a vessel such as a coronary artery, yet is visible under any of MRI, computer tomography or x-ray fluoroscopy. In general, metallic rings are aligned along a stent longitudinal axis and an outer layer of a first polymeric material covers the outer surface of the metallic rings, and an inner layer of a second polymeric material covers the inner surface of the metallic rings. At least one link connects adjacent metallic rings whereby the links are formed by the inner and outer polymeric materials. Virtually any stent pattern, of the many known stent patterns, can be used to form the hybrid stent of the present invention. Thus, while certain embodiments of the hybrid stent are described herein, they are for exemplary purposes only, and are not meant to be limiting.
Turning to the drawings, FIG. 1 depicts a hybrid stent 10 mounted on a catheter assembly 12 which is used to deliver the stent and implant it in a body lumen, such as a coronary artery, peripheral artery, or other vessel or lumen within the body. The catheter assembly includes a catheter shaft 13 which has a proximal end 14 and a distal end 16. The catheter assembly is configured to advance through the patient=s vascular system by advancing over a guide wire by any of the well known methods of an over-the-wire system (not shown) or a well known rapid exchange catheter system, such as the one shown in FIG. 1.
Catheter assembly 12, as depicted in FIG. 1, includes an RX port 20 where the guide wire 18 will exit the catheter. The distal end of the guide wire 18 exits the catheter distal end 16 so that the catheter advances along the guide wire on a section of the catheter between the RX port 20 and the catheter distal end 16. As is known in the art, the guide wire lumen which receives the guide wire is sized for receiving various diameter guide wires to suit particular applications. The stent is mounted on the expandable member 22 (a catheter balloon) and is crimped tightly thereon so that the stent and expandable member present a low profile diameter for delivery through the arteries.
As shown in FIG. 1, a partial cross-section of an artery 24 contains a small amount of plaque that has been previously treated by an angioplasty or other repair procedure. Stent 10 is used to repair a diseased or damaged arterial wall or a dissection or flap, which are commonly found in the coronary arteries and other blood vessels.
In a typical procedure to implant stent 10, the guide wire 18 is advanced through the patient=s vascular system by well known methods so that the distal end of the guide wire is advanced past the plaque or diseased area 26. Prior to implanting the stent, the cardiologist may wish to perform an angioplasty or other procedure (e.g., atherectomy) in order to open and remodel the vessel and the diseased area. Thereafter, the stent delivery catheter assembly 12 is advanced over the guide wire so that the stent is positioned in the target area. The expandable member or balloon 22 is inflated by well known means so that it expands radially outwardly and in turn expands the stent radially outwardly until the stent is supporting the vessel wall. The expandable member is then deflated and the catheter withdrawn from the patient=s vascular system. The guide wire typically is left in the lumen for post-dilatation procedures, if any, and subsequently is withdrawn from the patient=s vascular system. As depicted in FIGS. 2 and 3, the balloon is fully inflated with the stent expanded and pressed against the vessel wall, and in FIG. 3, the implanted stent remains in the vessel after the balloon has been deflated and the catheter assembly and guide wire have been withdrawn from the patient.
Due to the formation of the metallic portion of the hybrid stent 10 from a tube, the straight and undulating components of the stent are relatively flat in transverse cross-section, so that when the stent is expanded, it is pressed into the wall of the artery and as a result does not interfere with the blood flow through the artery. The stent is pressed into the wall of the artery and will eventually be covered with endothelial cell growth which further minimizes blood flow interference. The undulating portion of the stent provides good tacking characteristics to prevent stent movement within the artery. Furthermore, the cylindrical rings are closely spaced at regular intervals to provide uniform support for the wall of the artery, and consequently are well adapted to tack up and hold in place small flaps or dissections in the wall of the artery.
Turning to FIG. 4A, one embodiment of the hybrid stent 10 is shown as flat sheet, so that the pattern can be clearly viewed, even though the stent is not in this form when in use. The stent is typically formed from a tubular member, although it can be formed from a flat sheet and rolled into a cylindrical configuration or by other known means.
The hybrid stent 10 of the present invention, as shown in FIGS. 4-9, includes a metallic ring material 30 that provides structural support and vessel wall coverage. The metallic ring material is sandwiched through an outer polymeric material 31 and inner polymeric material 32 so that the metallic ring material is completely encased in the two polymeric layers or materials. Portions of the polymeric materials are removed to form links 33 which then connect the metallic ring material. The overall structure thus includes metallic rings connected by links, whereby the metallic rings are formed of a metal alloy sandwiched between an outer polymeric material and an inner polymeric material and the links which are formed of the outer polymeric material and the inner polymeric material. As shown, for example, in FIGS. 4C and 4D, the metallic ring material is sandwiched between an outer polymeric material and an inner polymeric material (FIG. 4C) while the cross-sectional view of the links (FIG. 4D) shows an outer polymeric material and an inner polymeric material bonded together. The polymeric links will increase the longitudinal and flexural flexibility of the stent which facilitates delivery of the stent through tortuous lumens, such as the coronary arteries or vessels in the brain. Further, the polymeric links will permit the stent to conform with arterial walls after expansion. The number of metallic rings and the number of connecting links can vary depending upon the application, and since the polymeric links are typically more flexible than prior art metallic links, more of the polymeric links connecting each ring are available, which provides more support for the vessel wall. Additionally, since the polymeric links are highly flexible, comparatively more metallic rings can be used than with conventional all metallic stents without compromising the overall flexibility of the stent. By increasing the number of polymeric links and the number of metallic rings, the amount of scaffolding or wall coverage provided by the stent is greatly increased, thereby reducing instances of plaque prolapse.
In one embodiment, the inner polymeric material 32 is made from polyetheretherketone (PEEK). PEEK offers a higher flexibility compared to most metallic alloys, for example, PEEK has a module of elasticity (E) of 4 GPa compared to stainless steel which has an E of 200 GPa. Further, PEEK has excellent radiographic qualities which include elimination of imaging artifacts and scatter generated from metallic implants which would prevent a complete visualization of tissue when using conventional imaging techniques such as x-ray, computer tomography or MRI. Since PEEK is MRI compatable, MRI technologies can be used to scan patients implanted with the hybrid stent 10 of the present invention having an inner polymeric material made from PEEK. Further, PEEK can be modified to enhance its radiopacity. For example, PEEK-OptimaJ (made by Invibio Biomaterial Solutions, Greenville, S.C.) has been modified to be radiopaque under fluoroscopy and is suitable for implant applications. The outer polymeric material 31 can be a polymer such as ethyl benyl alcohol (EVOH; available commercially as EVAL7, EVAL Company of America, Lisle, Ill.), which again provides flexibility that is comparable to PEEK, and is substantially more flexible than stainless steel, for example. The first and second polymeric materials can be taken from a group of polymeric materials which includes polyetheretherketone (PEEK), ethyl vinyl alcohol (EVOH), polyetherketone, polymethylmethacrylate, polycarbonate, polyphenylenesulfide, polyphenylene, polyvinylfluoride, polyvinylidene fluoride, polypropylene, polyethylene, poly(vinylidene fluoride-co-hexafluoropropylene), poly(ethylene-co-hexafluoropropylene), poly(tetrafluoroethyelene-co-hexafluoropropylene), poly(tetrafluoroethyelene-co-ethylene), polyethyleneterephthalate, polyimides and polyetherimide. Other polymeric materials that could be used to form the inner or outer polymeric material include ePTFE, polyurethanes, polyetherurethanes, polyesterurethanes, silicone, thermoplastic elastomer (e.g. C-flex), polyether-amide thermoplastic elastomer (e.g., Pebax), fluoroelastomers, fluorosilicone elastomer, styrene-butadiene-styrene rubber, styrene-isoprene-styrene rubber, polybutadiene, polyisoprene, neoprene, ethylene-propylene elastomer, chlorosulfonated polyethylene elastomer, butyl rubber, polysulfide elastomer, polyacrylate elastomer, nitrile rubber, a family of elastomers composed of styrene, ethylene, propylene, aliphatic polycarbonate polyurethane, polymers augmented with antioxidants, polymers augmented with image enhancing materials, polymers having a proton (H+) core, butadiene and isoprene (e.g., Kraton) and polyester thermoplastic elastomer (e.g., Hytrel) and a di-block co-polymer of PET and caprolactone. For strength, the polymer may further contain reinforcements such as glass fiber, carbon fiber, Spectra™, or Kevlar™.
In one embodiment, the outer polymeric material 31 and/or the inner polymeric material 32 are loaded with a therapeutic agent or drug for treating the artery or vessel in which the hybrid stent 10 is implanted. As an example, an anti-restenotic drug can be loaded into the PEEK or EVOH of the outer polymeric material or the inner polymeric material to reduce the likelihood of the development of restenosis of a coronary artery. In another embodiment, as shown in FIG. 4E, a cavity 34 is formed between the outer polymeric material 31 and the inner polymeric material 32 for containing a therapeutic drug 35. The drug would elute through the polymeric material at a controlled rate to treat the artery or vessel in which the stent is implanted. In the embodiment shown in FIG. 4E, cavity 34 is positioned between the first polymeric material and the second polymeric material in the polymeric link 33. One or more links can be formed to create the cavity and then loaded with a therapeutic agent or drug in order to prevent the development of restenosis, or to treat the artery or vessel for other conditions, such as to reduce clot formation.
Examples of therapeutic agents or drugs that are suitable for use with the outer and inner polymeric materials 31,32 include rapamycin, actinomycin D (ActD), or derivatives and analogs thereof. ActD is manufactured by Sigma-Aldrich, 1001 West Saint Paul Avenue, Milwaukee Wis. 53233, or COSMEGEN, available from Merck. Synonyms of actinopmycin D include dactinomycin, actinomycin IV, actinomycin 11, actinomycin X1, and actinomycin C1. Examples of agents include other antiproliferative substances as well as antineoplastic, antinflammatory, antiplatelet, anticoagulant, antifibrin, antithomobin, antimitotic, antibiotic, and antioxidant substances. Examples of antineoplastics include taxol (paclitaxel and docetaxel). Examples of antiplatelets, anticoagulants, antifibrins, and antithrombins include sodium heparin, low molecular weight heparin, hirudin, argatroban, forskolin, vapiprost, prostacyclin and prostacyclin analogs, dextran, D-phe-pro-arg-chloromethylketone (synthetic antithrombin), dipyridamole, glycoprotein, 11b/111a platelet membrane receptor antagonist, recombinant hirudin, thrombin inhibitor (available from Biogen), and 7E-3B7 (an antiplatelet drug from Centocore). Examples of antimitotic agents include methotrexate, azathioprine, vincristine, vinblastine, fluorouracil, adriamycin, and mutamycin. Examples of cytostatic or antiproliferative agents include angiopeptin (a somatostatin analog from Ibsen), angiotensin converting enzyme inhibitors such as Captopril (available from Squibb), Cilazapril (available from Hoffman-LaRoche), or Lisinopril (available from Merck); calcium channel blockers (such as Nifedipine), colchicine fibroblast growth factor (FGF) antagonists, fish oil (omega 3-fatty acid), histamine antagonist, Lovastatin (an inhibitor of HMG-CoA reductase, a cholesterol lowering drug from Merck), monoclonal antibodies (such as PDGF receptors), nitroprusside, phosphodiesterase inhibitors, prostaglandin inhibitor (available from Glazo), Seramin (a PDGF antagonist), serotonin blockers, steroids, thioprotease inhibitors, triazolopyrimidine (a PDGF antagonist), and nitric oxide. Other therapeutic substances or agents which may be appropriate include alpha-interferon, genetically engineered epithelial cells, and dexamethasone.
The metallic ring material 30 of the present invention can include alloys such as stainless steel, titanium, tantalum, nickel-titanium, cobalt-chromium, tungsten, and similar metallic alloys that are biocompatible and that are generally known for use as intravascular stents.
The hybrid stent 10 of the present invention can be incorporated in a wide range of stent patterns that are widely known and currently available. Many of the currently available stent patterns include some combination of cylindrical rings that have an undulating shape that is crimpable onto the balloon portion of a catheter and expandable for implanting in an artery or a vessel. Typically, the rings are connected by connecting members or links with both the rings and links being formed of the same metal, such as stainless steel, titanium, or cobalt-chromium. Thus, the hybrid stent of the present invention can be used to make any of the following commercially available stents that go by the trade names ACS Multi-Link7 family of stents made by Advanced Cardiovascular Systems, Inc., Santa Clara, Calif.; the BX Velocity Stent7 made by Cordis, a Johnson & Johnson company, Warren, N.J.; the AVE S6707 and S77 stents made by AVE, a division of Medtronic Corporation, Minneapolis, Minn.; and the NIR7 and the Express7 stents made by Medinol and distributed in the United States by Boston Scientific, Corp., Natick, Mass. As a further example, an ACS Multi-Link7 PENTA stent is further described herein for purposes of illustration to demonstrate its conformability to the hybrid stent 10 of the present invention.
In keeping with the invention, as shown in FIGS. 4-9, one embodiment of the hybrid stent 10 is made up of cylindrical rings 40 which extend circumferentially around the stent when it is in a tubular form. The stent has a delivery diameter 42 as shown in FIG. 5, and an implanted diameter 44 as shown in FIG. 3. Each cylindrical ring 40 has a cylindrical ring proximal end 46 and a cylindrical ring distal end 48. Typically, since the stent is laser cut from a tube, there are no discreet parts such as the described cylindrical rings. However, it is beneficial for identification of various parts to refer to the cylindrical rings and other parts of the stent.
Each cylindrical ring 40 defines a cylindrical plane 50 which is a plane defined by the proximal and distal ends 46, 48 and the circumferential extent as the cylindrical ring travels around the cylinder. Each cylindrical ring includes cylindrical outer wall surface 52 which defines the outermost surface of the stent, and cylindrical inner wall surface 53 which defines the innermost surface of the stent. Cylindrical plane 50 follows the cylindrical outer wall surface.
Undulating link 54 is positioned within cylindrical plane 50 such that the undulating links connect one cylindrical ring to an adjacent cylindrical ring and provide overall longitudinal flexibility to the stent due to their unique construction. The flexibility of undulating links derives in part from bends 56 connected to straight portions 58 wherein the straight portions are substantially perpendicular to the longitudinal axis of the stent. Thus, as the stent is being delivered through a tortuous vessel, such as a coronary artery, the bends 56 and straight portions 58 of the undulating links will permit the stent to flex in the longitudinal direction which substantially enhances delivery of the stent to the target site. The number of bends and straight portions can be increased or decreased from that shown, to achieve differing flexibility constructions. With the straight portions being substantially perpendicular to the stent longitudinal axis, the undulating link acts like a hinge to provide flexibility.
Referring to FIGS. 4A, 4B and 5, the stent 10 can be described more particularly as having a plurality of peaks 70 and valleys 72. Although the stent is not divided into separate elements, for ease of discussion references to peaks and valleys is appropriate. The number of peaks and valleys, sometimes referred to as crowns, can vary in number for each ring, depending upon the application. Thus, for example, if the stent is to be implanted in a coronary artery, a lesser number of peaks and valleys (or crowns) are required than if the stent is implanted in a peripheral artery, which has a larger diameter than a coronary artery. As can be seen in FIGS. 4A and 4B, peaks 70 are substantially in phase when looking at every other cylindrical ring 40. The in-phase relationship is identified by reference number 74. It may be desirable under certain circumstances to position peaks 70 so that they are in phase in every cylindrical ring (not shown). As shown in FIG. 4A, the peaks are circumferentially offset from the valleys and from the undulating link 54. Positioning the peaks, valleys, and undulating links in this manner provides a stent having uniform expansion capabilities, high radial strength, a high degree of flexibility, and sufficient wall coverage to support the vessel.
Referring to FIGS. 6-9, the stent can be described as having U-shaped portions 90, Y-shaped portions 92, and W-shaped portions 94. Again, while the cylindrical rings are generally laser cut from a tube and the stent typically has no discreet parts, for ease of identification the stent of the invention also can be referred to as having U-, Y-, and W-shaped portions. The U-shaped portions have no supporting structure attached thereto. The Y-shaped portions, at their base, or apex, have arm 95 extending therefrom and attached to undulating link 54. The W portion has at its base or curve portion arm 96 which attaches at the other end of the undulating link. The length of the arms attaching the links to the rings can vary. Importantly, the arms should be sized in conjunction with the undulating link. Preferably, undulating link 54 is contained within W-shaped portion 94, which should be wide enough to accommodate the undulating link when the stent is crimped so that no portion of the undulating link and the W-portion overlap. Preferably, the undulating link and the W-shaped portion are in the same cylindrical plane 50 as defined by the cylindrical outer wall surface 52 and the cylindrical inner wall surface 53. FIG. 9 shows one embodiment of the hybrid stent 10 in a flattened configuration and expanded. Again, the stent normally is not in this configuration (flattened and expanded) and shown for illustration purposes to better understand the invention.
One embodiment of the hybrid stent 10 of the present invention includes a superelastic material in the metallic rings and/or the polymeric links. The term "superelastic" refers to an isothermal transformation, more specifically stress inducing a martensitic phase from an austenitic phase. Alloys having superelastic properties generally have at least two phases: a martensitic phase, which has a relatively low tensile strength and which is stable at relatively low temperatures, and an austenitic phase, which has a relatively high tensile strength and which is stable at temperatures higher than the martensitic phase. The austenitic phase also typically has better corrosion properties. Superelastic characteristics generally allow the metal stent to be deformed by collapsing and deforming the stent and creating stress which causes the metal to change to the martensitic phase. The stent is restrained in the deformed condition to facilitate the insertion into a patient's body, with such deformation causing the phase transformation. Once within the body lumen, the restraint on the stent is removed, thereby reducing the stress therein so that the superelastic stent can return towards original undeformed shape by the transformation back to the austenitic phase. A basic discussion of this phenomenon can be found in Wayman and Deuring, An Introduction to Martensite and Shape Memory, @ which appears in Engineering Aspects Of Shape Memory Alloys, Deuring et al. editors (Butterworth-Heinemann Ltd. 1990, Great Britain.)
In this embodiment, the cylindrical ring material 30 of the hybrid stent 10 are formed from a superelastic material such as NiTi and undergo an isothermal transformation when stressed. The stent is first compressed to a delivery diameter, thereby creating stress in the NiTi alloy so that the NiTi is in a martensitic state having relatively low tensile strength. While still in the martensitic phase, the stent is mounted onto a catheter by known methods.
When stress is applied to a specimen of a metal such as nitinol exhibiting superelastic characteristics at a temperature at or above that which the transformation of the martensitic phase to the austenitic phase is complete, the specimen deforms elastically until it reaches a particular stress level where the alloy then undergoes a stress-induced phase transformation from the austenitic phase to the martensitic phase. As the phase transformation progresses, the alloy undergoes significant increases in strain with little or no corresponding increases in stress. The strain increases while the stress remains essentially constant until the transformation of the austenitic phase to the martensitic phase is complete. Thereafter, further increase in stress is necessary to cause further deformation. The martensitic metal first yields elastically upon the application of additional stress and then plastically with permanent residual deformation.
If the load on the specimen is removed before any permanent deformation has occurred, the martensite specimen will elastically recover and transform back to the austenitic phase. The reduction in stress first causes a decrease in strain. As stress reduction reaches the level at which the martensitic phase transforms back into the austenitic phase, the stress level in the specimen will remain essentially constant (but less than the constant stress level at which the austenitic crystalline structure transforms to the martensitic crystalline structure until the transformation back to the austenitic phase is complete); i.e., there is significant recovery in strain with only negligible corresponding stress reduction. After the transformation back to austenite is complete, further stress reduction results in elastic strain reduction. This ability to incur significant strain at relatively constant stress upon the application of a load and to recover from the deformation upon the removal of the load is commonly referred to as superelasticity.
The prior art makes reference to the use of metal alloys having superelastic characteristics in medical devices which are intended to be inserted or otherwise used within a patient=s body. See, for example, U.S. Pat. No. 4,665,905 (Jervis) and U.S. Pat. No. 4,925,445 (Sakamoto et al.), which are incorporated by reference herein in their entirety.
FIG. 10 illustrates an example of a stress-strain relationship of an alloy specimen, the cylindrical rings having superelastic properties as would be exhibited upon tensile testing of the specimen. The relationship is plotted on x-y axis, with the x axis representing strain and the y axis representing stress. For ease of illustration, the x-y axes are labeled with typical pseudoelastic nitinol stress from 0 to 60 ksi and strain from 0 to 9 percent, respectively.
Looking at the plot itself in FIG. 10, the line from point A to point B represents the elastic deformation of the specimen. After point B the strain or deformation is no longer proportional to the applied stress and it is in the region between point B and point C that the stress-induced transformation of the austenitic phase to the martensitic phase begins to occur. There also can be an intermediate phase, called the rhombohedral phase, depending upon the composition of the alloy. At point C moving toward point D, the material enters a region of relatively constant stress with significant deformation or strain. This constant or plateau region is known as the loading stress, since it represents the behavior of the material as it encounters continuous increasing strain. It is in this plateau region CD that the transformation from austenite to martensite occurs.
At point D the transformation to the martensitic phase due to the application of stress to the specimen is substantially complete. Beyond point D the martensitic phase begins to deform, elastically at first, but, beyond point E, the deformation is plastic or permanent.
When the stress applied to the superelastic metal is removed, the material behavior follows the curve from point E to point F. Within the E to F region, the martensite recovers its original shape, provided that there was no permanent deformation to the martensitic structure. At point F in the recovery process, the metal begins to transform from the stress-induced, unstable, martensitic phase back to the more stable austenitic phase.
In the region from point G to point H, which is also an essentially constant or plateau stress region, the phase transformation from martensite back to austenite takes place. This constant or plateau region GH is known as the unloading stress. The line from point I to the starting point A represents the elastic recovery of the metal to its original shape.
Binary nickel-titanium alloys that exhibit superelasticity have an unusual stress-strain relationship as just described and as plotted in the curve of FIG. 10. As emphasized above, the superelastic curve is characterized by regions of nearly constant stress upon loading, identified above as loading plateau stress CD and unloading plateau stress GH. Naturally, the loading plateau stress CD is always larger than the unloading plateau stress GH. The loading plateau stress represents the period during which martensite is being stress-induced in favor of the original austenitic crystalline structure. As the load is removed, the stress-induced martensite transforms back into austenite along the unloading plateau stress part of the curve. The difference in stress between the stress at loading CD and unloading stress GH defines the hysteresis of the system. This is identified as Δy of the curve in FIG. 10.
The present invention seeks to minimize the hysteresis of the superelastic material used for the self-expanding rings of the hybrid stent. The rings are designed to perform various mechanical functions within a lumen, all of which are based upon the lower unloading plateau stress GH. Unloading plateau stress GH represents the behavior of the nitinol material when the stent is deployed.
On the other hand, the higher loading plateau stress CD establishes the mechanical resistance the cylindrical rings exert against the delivery system, and specifically delivery sheath or restraint. It represents the stress exerted by the end-rings when they are loaded into a restraint. The greater the difference between the two plateaus CD and GH is (the hysteresis), the stronger the delivery system must be to accommodate any given level of stent performance.
Conversely, reducing the difference or Δy between the two plateaus CD and GH results in smaller hysteresis. The smaller the hysteresis is, the smaller and lower profile the delivery system has to be to accommodate any given level of stent performance. Furthermore, the present invention delivery system can be smaller and constructed to a smaller profile due to the lower loading plateau stress CD, while maintaining a high hoop strength of the deployed, expanded stent represented by plateau stress GH.
The superelastic alloy is preferably formed from a composition consisting essentially of about 30 to about 52 percent titanium and the balance nickel and up to 10 percent of one or more additional ternary alloying elements. Such ternary alloying elements may be selected from the group consisting of palladium, platinum chromium, iron, cobalt, vanadium, manganese, boron, copper, aluminum, tungsten, or zirconium. In particular, the ternary element may optionally be up to 3 percent each of iron, cobalt, platinum, palladium, and chromium, and up to about 10 percent copper and vanadium. As used herein, all references to percent composition are atomic percent unless otherwise noted. Platinum is the preferred ternary element at 7.5 atomic percent.
In another embodiment, a NiTi cylindrical ring with SME (shape memory effect) is heat-treated at approximately 500 E C. The stent is mechanically deformed into a first, smaller diameter for mounting on a catheter delivery system that includes an expandable balloon and inflation lumen. After the stent has been expanded by the balloon and deployed against arterial wall, 45 E C heat is applied causing the cylindrical rings to return to their fully expanded larger diameter and to be in contact with the arterial wall of the artery. The application of 45 E C of heat is compatible with most applications in the human body, but it is not to be limited to this temperature, as higher or lower temperatures are contemplated without departing from the invention. The 45 E C temperature can be achieved in a conventional manner well known in the art, such as by warm saline injected into the delivery catheter and balloon.
In the embodiment in which the cylindrical ring material 30 is formed of a superelastic or shape memory effect metal alloy, such as NiTi, one or both of the polymers also can be formed of a shape memory polymer. Various shape memory polymers for biomedical applications can include oligo (e-caprolactone), dimethacrylate and n-butyl acrylate. Both of these shape memory polymers are monomeric compounds which, when combined, generate a family of polymers that exhibit excellent memory characteristics. The oligo (e-caprolactone) dimethacrylate furnishes the crystalisable Aswitching@ segment (which is characteristic of shape memory materials changing from one Aphase@ to another) that determines both the temporary and the permanent shape of the polymer. By analogy, the temporary shape is similar to the martensitic phase of a metallic NiTi material, while the permanent shape of the polymer is similar to the austentic phase of the NiTi alloy. By varying the amount of the comonomer, n-butyl acrylate, in the polymer compound, the cross-link density can be varied. This allows the mechanical strength and the transition temperature of the polymers to be tailored over a wide range, which can be coordinated with the NiTi alloy to provide the required shape memory characteristics of the overall stent having both metallic rings and polymer links.
The hybrid stent of the present invention can be manufactured in many ways. In one embodiment, as shown in FIGS. 11-13, the metallic ring material 30 is sandwiched between or encased within outer polymeric material 31 and inner polymeric material 32. In keeping with the method of making the hybrid stent, in one embodiment, the metallic ring material 30 is cut from a tube in a conventional manner by a laser cutting procedure. One such method of laser cutting metallic rings and stent patterns in general is described in U.S. Pat. No. 5,759,192 to Saunders, which is incorporated by reference herein. The inner polymeric material 32 is mounted on a mandrel 100 so that it is a tight fit, and the metallic ring material is thereafter positioned over the inner polymeric material. The inner polymeric material can be in the form of a tube. After the metallic ring material is positioned over the inner polymeric material, the outer polymeric material, in the form of a polymeric tube, is positioned over the metallic rings and the inner polymeric material. A shrink tubing 102 is then mounted over the outer polymeric material and then exposed to heat, by a laser 104 to shrink the shrink tubing which in turn applies compressive pressure on the outer polymeric tube. As the outer polymeric tube compresses against the metallic rings and the inner polymeric tube, the heat from the laser causes the inner and outer polymeric materials to melt and fuse together. To facilitate adherence between the inner and outer polymeric materials, an appropriate adhesive or bonding agent 106 can be used in addition to the heat process from the laser. After fusing the inner and outer polymeric materials, the shrink tubing and the mandrel are removed and a laser is used to remove unwanted portions of the polymer to produce the desired stent pattern. For example, as previously described with respect to the stent pattern of FIGS. 4-9, the laser removes portions of the inner and outer polymeric material to form connecting links between the metallic ring material. The resulting stent pattern of rings and links can then be used in conjunction with a stent delivery catheter as shown in FIGS. 1-3 to deliver and implant the stent in a vessel or artery.
In another embodiment, as shown in FIG. 13, in which the metallic ring material 30 is encased or sandwiched between the inner polymeric material 32 and the outer polymeric material 31, a mandrel 100 is first dip coated with the polymer corresponding to the inner polymeric material. The metallic ring material is then positioned on the inner polymeric material which is coating the mandrel. The outer layer of polymeric material is deposited over the metallic ring material and the inner polymeric material either by dip coating or spray coating. Thereafter, the stent having the metallic ring material encased within the inner and outer polymeric materials is removed from the mandrel and by use of a laser or equivalent procedure, the unwanted portions of the polymers are removed to develop the stent pattern.
While the invention has been illustrated and described herein in terms of its use as an intravascular stent, it will be apparent to those skilled in the art that the stent can be used in other body lumens. Further, particular sizes and dimensions, materials used, and the like have been described herein and are provided as examples only. Other modifications and improvements may be made without departing from the scope of the invention.


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Well, perhaps I should rephrase that as, "Who is Benjamin Koss to my family?" None of the names in the obituary are in my family tree or even familiar to me. I can only imagine that this article was clipped because of his position in the community in which my husband's ancestors lived. A rather gruesome recounting of the death as well.
I don't know which paper it was published in (I'll add that to my list of things to check on!), but most of the articles that were passed on were from the Green Bay Press-Gazette. This one is hand-dated October 31, 1956. I have noticed that this usually refers to the date of death rather than of publication.
I won't completely rule out that this person may have a place in my family tree, but for now I'm thinking no. Perhaps the article will fit into another researcher's tree.
"Koss Killed In Accident With Sawmill
[Hand-dated Oct 31, 1956]
Town of Luxemburg Chairman; Funeral Rites Set Saturday
LUXEMBURG, Wis. - A portable sawmill accident Tuesday afternoon cost the life of Benjamin Koss, 45, of Luxemburg, Rt. 2. He was chairman of the Town of Luxemburg and chairman of the Kewaunee County highway committee.
Koss was feeding logs into the machine on the Allen Farm in the Town of Preble. A slab of wood kicked back and struck him below the chin, severing his jugular vein. He was dead on arrival at a Green Bay hospital.
The accident happened about 4 p.m. Tuesday.
Owned Portable Mill
Mr. Koss, who operated a farm in the Town of Luxemburg, did custom sawing with a portable powered rig.
He was serving his third term as chairman of the Town of Luxemburg. Previously he had served two terms as town treasurer.
Mr. Koss was a member of the Luxemburg Court of the Catholic Order of Foresters and of the Holy Name Society of St. Odile Church, Thiry Daems.
He was born May 18, 1911, in the Town of Lincoln, Kewaunee County. In 1932 he married to Collette Junion in St. Odile Church.
Survived by Wife
Survivors include his wife; a daughter, Karen, at home; four sons, Eben, Glen and Karl, all at home, and Gene, who is stationed with the U. S. Army at Ft. Lawton, Seattle, Wash.; one granddaughter, and his parents, Mr. and Mrs. John A. Koss, Town of Lincoln.
Also surviving are two sisters, Mrs. Lee (Marie) Fett, and Mrs. Frank (Rita) Havel, both of the Town of Lincoln; and two brothers, John, Rio Creek, and Matt, Green Bay.
Funeral services will be held at 9:30 Saturday morning at St. Odile Church, Thiry Daems. The Rev. Anthony J. Righino will officiate.
Friends may call at the Weisner-Massart Funeral Home, Casco, after 6 o'clock this evening. The Rosary will be recited at the funeral home at 8 o'clock this evening and Friday evening and 8:45 on Thursday evening."


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Cops: Show reminder girl was in car
WICHITA, Kan. – A child crying on the television show "Game of Thrones" jogged a foster parent's memory that he had left a 10-month-old girl inside a sweltering car while he and his partner smoked marijuana at their house, a police affidavit released Monday says.
More details of the Kansas case surfaced in the affidavit made public Monday. The document also says Seth Jackson and his partner were smoking marijuana while the child was inside the car in Wichita, where it was around 90 degrees outside.
Jackson, 29, is charged with first-degree murder in the July 24 death. No charges have been filed against his partner.
Police say the girl was inside the car with the windows up for more than two hours. According to the affidavit filed by Wichita police detective Ryan Schomaker, Jackson's partner told investigators that the girl was hot and stiff when he grabbed her from the vehicle and took her into the house. He called 911, while Jackson attempted CPR but could not get her mouth open.
Police who first responded to the call found Jackson on the phone and the unresponsive girl lying on her back on the couch. Firefighters arriving on the scene moved the girl from the couch to the floor to attempt to revive her.
Another officer at the scene also reported observing Jackson standing in the front yard. Jackson made about four separate phone calls stating, "I left her in the car, she's dead, she's dead," according to the affidavit.
Jackson told the officer he had arrived home after picking up the girl from the baby sitter, along with some pizza. When he arrived home he locked the car and went inside with the pizza and his 5-year-old adopted child who was also with him.
In an interview at police headquarters, Jackson's partner told detectives he and Jackson had been foster parents to the 10-month-old girl since she was 2 weeks old. Police have not released the child's name and documents in the case only use her initials.
Jackson's partner told police that Jackson had called earlier on July 24 after taking the 5-year-old to a doctor's appointment to let him know he would be picking up the 10-month-old girl from the baby sitter. He said he was working in the backyard when Jackson came home.
He told detectives that they watched one and a half episodes of "Game of Thrones" and smoked marijuana Jackson had picked up that day. Jackson realized the 10-month-old girl was still inside the vehicle when he heard a child crying on the television show, the affidavit says.
An autopsy on the girl showed she died of hyperthermia due to heat exposure, according to the affidavit. But Sedgwick County District Attorney Marc Bennett said the charge was warranted because the child died during the commission of an inherently dangerous felony, aggravated endangering of a child. The case is not charged as intentional murder.
Jackson and his partner had been trying to adopt the 10-month-old girl. They also had three other foster children ages 3, 5 and 18, and two adopted children ages 5 and 7. The two younger foster children were visiting other relatives at the time the 10-month-old died.
Prosecutors and Jackson's attorneys agree the circumstances are entirely different than a widely publicized case in Georgia, where a father faces murder and child cruelty charges on suspicion of intentionally leaving a 22-month-old boy inside a hot car last month as he went to work.


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Former Microsoft Dealmaker Fritz Lanman Launches Livestar Recommendations App
At 30 years old, Livestar CEO Fritz Lanman is leading an inverted tech career.
He's stepping away from the multibillion-dollar takeover attempts and the killer angel investing portfolio to launch a little start-up of his own.
Livestar is one of those companies that makes an app that's ever so subtly different from something lots of other people are trying to do. It's a personalized recommendations iPhone app for all sort of things. If you follow this stuff closely, think: Oink, Stamped and Jotly.
Seattle-based Livestar is — of course! — starting with restaurant recommendations, like other would-be Foursquare- and Yelp-killers such as Ness and Nosh and Alfred. It also plans to add movies, music and wine.
But Lanman thinks he has a couple of things figured out better than other people: Livestar is seeded with expert content and reviews from everywhere else, so it doesn't feel empty at first. And the app is designed around friends asking friends — via Facebook and text message — to fill out quick ratings forms so it can build its own content.
Lanman said he thinks this social obligation will be a stronger motivator for participation than Foursquare check-ins or Yelp community ego-boosting.
A little background on Lanman: After graduating with a history major from Yale in 2003, he landed on the Internet strategy team at Microsoft. Lanman is one of those lanky, friendly guys that seems to be undaunted and comfortable in any situation, which is perhaps why he was able to play a role in huge deals at such a young age.
While at Microsoft, Lanman helped try to buy Facebook and internally put his career on the line to justify an investment in the social network at a then-incredible valuation of $15 billion in 2007. He then helped lead Microsoft's $44.6 billion bid to take over Yahoo in 2008, which ended up in a search deal instead.
Then, in the past two years, Lanman became an angel investor, with 30 consumer Internet start-ups backed, including Square and Pinterest.
But what he really wanted to do was start his own thing.
Livestar's team of seven, based in Seattle, has spent the past year analyzing expert opinions and user reviews from sites like Yelp and turning them into star ratings (it doesn't have official licenses to any of this content, but links out in order to drive traffic to it). The app also includes each restaurant's menu and at-a-glance information.
The crux of the app is the part that surveys users and their friends about their opinions, by asking them to contribute their own star ratings. Building a critical mass of content here is going to be hard, which Lanman readily admits.
Livestar has raised about $2 million from angel investors including Allen and Co., Blake Krikorian, Owen van Natta, Vivi Nevo, Troy Carter, Casey Wasserman, Chernin Group, SV Angel, Mitch Kapor, Paul Buchheit, Hadi and Ali Partovi and Ray Ozzie.