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Kid-friendly taprooms booming in the East Bay. Is that a good thing?
The customer's jutting chin issued a challenge. Then came a groan, as if I'd voiced an offensive political opinion, followed by the laugh, an insolent, spittly bray. The bartender smiled beatifically, seemingly fine with one customer bullying another.
"Can I help you with something?" I ventured to my neighbor.
"A quesadilla?" asked the customer, my then-3-year-old daughter.
At Oakland brewery Old Kan Beer and Co., she could have that quesadilla paired with a jug of Martinelli's — the easy-chugging Pabst-tall can for the preschooler set. With a box of toys, that apple juice and several menu items uncomplicated by chile oil, Old Kan pleases the smallest (and toughest) of customers without coming off like an indie Chuck E. Cheese.
In the past five years, many East Bay taprooms and bars seem to have opened with my ilk in mind: parents, semiretired from dive bars, looking for somewhere convivial with good beer, music that won't blister eardrums, perhaps some outdoor seating and, without any tacky pandering, a warm (though obviously conditional) acceptance of children.
They run the gamut from quietly accommodating (juice options, booster seats, BYOT — Bring Your Own Toys) to (at times) kid-dominated (games, art supplies, play spaces).
In Berkeley, Westbrae Biergarten has a "kids only" area with chalkboard walls and soft mulch-y bedding to protect tumbling youngsters from injuries. A few steps from its namesake, MacArthur BART, Arthur Mac's has a sandbox and arcade games. On its website, Temescal Brewing Company invites "well-behaved" children. Novel Brewing Co. offers board games and $1 cheddar goldfish cartons. Open since 2018, Albany's Ocean View Brew Works rolls out a play kitchen and giant Connect 4.
While kid-friendly drinking isn't exclusive to the Bay Area, the model feels particularly evolved in the East Bay, where parents with some degree of disposable income are culturally comfortable with rosé and craft beer as logical accompaniments to playdates and kiddie birthday parties — or at least are keen to save money on a babysitter. Saturday afternoon at, say, Temescal Brewing Co. can look like a cut scene from "Blindspotting": a predominately white crowd, toddlers, lolling dogs and food trucks not too far from streets where, 10 years ago, affluent families would have been disinclined to live.
While the proliferation of family-friendly bars is more a symptom of gentrification and displacement than the cause, it's impossible to ignore the elephant on the picnic table-filled patio.
Old Kan co-owner Adam Lamoreaux's two kids frequently hang out at his bar. On one of my visits a few years ago, his daughter authoritatively presented an official business card advertising her babysitting services.
"She's grown up in this place," said Lamoreaux, whose partner, James Syhabout of Commis and Hawker Fare, has two children as well. "We think of kids when we think of anything."
That's not exactly a common sentiment among bar owners. While I've never seen children causing havoc at Old Kan, grievances on Yelp about a couple of the other establishments referenced in this article often concern the behavior of kids. Sand kicked up into clouds. Wailing juvenile pterodactyls scourging the terrain.
"I've definitely heard people complain that they can't enjoy beer in taprooms without kids running around," Lamoreaux said. "It's a choice."
Still, many of these bars' owners make a (possibly) semantic point that they don't really cater to children. No brewery or bar wants to be known as the destination for every parent whose energetic little rascals want to spark sandbox drama. On Yelp, the opposite complaint surfaces, too: that bars ostensibly welcoming kids — and profiting from the presence of families — shouldn't protest when those kids cut a little too loose.
"We made the decision to allow kids because we respect the community," said Teresa Tamburello of Novel, which, with its stacks of Pynchon and literary beer descriptions, skews more liberal arts than child development.
Novel chose to sell only its own beer in part to be permitted as a tasting room and thus allow children accompanied by adults. Unless a bar is selling its own brews exclusively, even a watering hole offering only beer and wine needs to have a food menu in order for kids to enter. Otherwise, as many a 20-year-old with a bad fake knows, such bars only serve adults over 21.
Tamburello isn't the only proprietor to frame the policy in terms of community and neighborhood.
Bring the kids
Arthur Mac's Tap & Snack 4006 Martin Luther King Jr. Way, Oakland, 510-823-2509, www.arthurmacs.com
Ocean View Brew Works 627 San Pablo Ave., Albany, 510-280-5127, www.oceanviewbrews.com
Old Kan Beer and Co. 95 Linden St., Oakland, 510-338-3965, www.old-kan.com
Novel Brewing Co. 6510 San Pablo Ave., Oakland, 510-922-9974, www.novelbrewing.com
Westbrae Biergarten 1280 Gilman St., Berkeley, 510-647-9079, www.westbraebiergarten.com
"It's really a community focus," said Joel DiGiorgio of Arthur Mac's Tap & Snack, which his company, Farm League Design and Management Group, opened in 2017. "A babysitter costs $20 an hour. If we can make (coming here) fun for kids and save parents money, we know we've been successful."
An East Bay native who graduated from UC Berkeley, DiGiorgio believes that many of the now-defunct kid-friendly establishments that once lined his old College Avenue stomping grounds couldn't survive because they satisfied children at the expense of parents, who grew to expect better food and drinks.
A father of two himself, DiGiorgio decided that Arthur Mac's, which serves pizza and beer in the diverse Longfellow neighborhood, had to be both affordable and welcoming — designed so young people meeting for dates could avoid 2-year-olds painting their faces with marinara sauce.
"We built the play area around the back. There are fire pits for adults at one end, and they're separate — far apart."
Farm League also designed and launched Westbrae Biergarten in 2014, but has since sold its stake. In the case of that bar, the nods to children were gradual, a response to the throngs of child-toting parents showing up.
Also parents, Ocean View Brew Works owners Scott and Vonnie Davidson book mellow music for afternoons, schedule arts and crafts activities, maintain a Lego collection and try to think of imagination-inspiring props that can be built into the back area, like steering wheels affixed to the side of a building.
"Families make up 70% of our business," said Scott Davidson. "We want it to be the best environment."
DiGiorgio characterizes Arthur Mac's as a "neighborhood backyard," and, without prompting, Vonnie Davidson echoed the line to describe Ocean View Brew.
"We want to provide something for everyone," said Vonnie Davidson, a public elementary schoolteacher. "Regulars bring their kids and they play with ours. It's about enjoying a public space away from a playground."
When the line between adult and kid space blurs, new standards emerge. An idyllic "neighborhood backyard" scene can turn hectic and unsafe if parents are more devoted to what fills their glasses than watching their children.
"We have a great clientele, but it's hard to address that when it happens," said Teresa Tamburello of Novel.
"You get this 'Lord of the Flies' scenario," said DiGiorgio. "Kids are ruthless. They climb on everything. There are extra janitorial and furniture costs."
"We say, 'Sorry, kids have to wear shoes,'" said Vonnie Davidson. "Glass does break. There are social norms."
Attending a birthday party for a preschooler at Westbrae Biergarten, I certainly saw some mayhem: kids hurling chalk; a little boy throttling his sister; his mom running back, sangria in hand, to shake his arm vigorously before leaving him to continue throttling his sister. Parents were perhaps letting their kids free-range a little too freely.
But parents aren't the only ones who benefit from adult spaces that accommodate children. Kids can benefit, too, from learning how to share and advocate for themselves in a place where they're encountering strangers on less familiar terrain. Knowing how to act in a public setting not designed purely for the comfort of a child is good for kids.
On a recent Thursday afternoon, I visited Ocean View Brew Works alone, my daughter (and usual happy hour companion) at her grandmother's house. Only one kid was there, a wide-eyed sturdy toddler gnawing corkscrew pasta and tossing plastic automobiles like Godzilla. A woman boomed, "I see your belly," and went in for a sly tickle that produced the hoped-for gurgle of delight.
When the toddler ran for the patio, the dad dashed after him, beer held aloft, toddling himself to avoid spillage.
Sitting at the bar with a novel, I felt suddenly lonely as I watched the father, his son, and the beer return. I was at a bar, many a parent's escape from home, and yet thinking: If only my daughter were here.
Andrew Simmons is a freelance writer based in the East Bay. Email: firstname.lastname@example.com


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Thank you. Will stay tuned.
Thank you. Will stay tuned.
Signature Removed - Read this.
-TWC moderation Staff
Hi , don't know if below things have been mentioned before, but these are what I noticed so far in my campaign (0.96+patch1) :
- flags around the city center are still medieval-flags.
- cretan archer picture in the pop-up description is a peasant picture.
- units get no experience upgrade after a battle.
- units can not be upgraded/retrained after building some armoury building in settlements.
No CTD's yet, so that's an awesome thing.....and your patch1 brought incredible upgrades in quality in comparison to the unpatched 0.96: Really much more fun to play the patched version !!
Keep up the good work !
PS How many members are in the PI2 team nowadays ?
i wouldn't say any of these things are necessarily bugs, just things that havn't been changed yet, atm there are 3 regularly active, and together we are working on unit improvements and 2d art improvements, i think someone on the team with more experience with coding or whatever can talk to you about unit experience and retrainingt. ect
I must say that other members are working on Script.
We are not so much members . But the one said above, and the two others working on the scripts are active.
Concerning the flag, it's the medieval one because we haven't work on that i think.
As the cretan archer will change with the new models we are creating, the picture will change soon, but good to know that yet the picture isn't the right one.
For the upgrade, don't know why it doesn't work, good to have notice it. (i don't know if the team worked on that part previously).
EBII fan appeal: The Europa Barbarorum II team [M2TW] is in dire need of YOUR HELP RIGHT NOW! - Dear modders, please get in touch HERE!
I was just starting a new Etruscan campaign, and I was dithering between the Raseanna or Tuscan Leagues. While clicking between the two options in the faction selection menu, I noticed that the faction area shown on the mini map doesn't correspond to either faction, as they seem to be switched. Here's a pic illustrating what I'm talking about:
Spoiler Alert, click show to read:
As you can see, while the Raseanna league is selected, the map is displaying the territory of the Tuscan league.
Client of Каие, patron of Ariovistus Maximus, Tiberios, Babur, Sir Pignans and Nevins
Hello all!
A few of us have had trouble with archers/skirmishers(ground and cav) in this game. After a couple hours of testing(i think all of them) I tweaked some of their values and found some of the formation spacing was set too high(/shrug as to how it actually created a prob) Anyway i set all of the high unit count(didn't adjust ANY low unit # squads ie: 12-20man units, they all worked fine) archers to a value as high as 1.6, 3.2, 6. Anything higher kept making the buggy ones not fire right. The only unit i couldn't fix was GCS Pheraspis Tarentine Calvary. The throwing animation for this unit seems to be missing.
Feel free to use this if you wish. My only hope is to save you guys time. Happy New Year!!
TY, gonna wait for the next version, Its on the horizon... I can smell it
I CTD when I joined a battle at the city Northeast of...crap I cant remember The settlement starts with C and is in the mountains. Playing as the Romans and have a full army attacking some rebels. I skirmish for a bit then when the battle is joined I crash. This didnt happen at any of the other battles before, though I saved then got off then got back on. Other than that great, amazing, fantastic mod!!! I love it! The attention to detail, the tactics its just amazing.
How we make to recruit diplomats?
i ' began two campaigns with syracuse and the Greek cities, I do not find .
diplomat fix:
i just downloaded pi2 and in my first siege of agaria my game craches all the time, i play as romans
error says medival kingdoms stopt working for an unknown problem?
did i something wrong with installing this mod
I get that error too.
I made an complete fresh re-installation now but the problem is still there.
When I play as the greeks and attack a Brettian town and then they sally forth to meet me, I don't experience any ctd.
But when I play as Carthage and attack Hyppana (rebel town) and they sally forth to meet me, I experience ctd.
Custom siege battles also gives ctd.
i cant even start the game, when at the first loading screen it says: "Med2TW encountered an unspecific error and will now exit."
i installed it over a totally new kingdoms, with one mod in it, which works properly!
Please help, v 0.96 worked without issues!
thanks for the help!!!
EB II is finally out! ...NOW!!!...
I however get a CTD when i click custom battles in the start menu. The campaign so far has given me no malfunctions, including a siege battle in which the enemy sallied out. For some reason however the screen shrinks during the starting of the game, meaning the desktop background is visible right and under the (not fullscreen, as usual) game screen.
Help would be much appreciated!
It's okay The important thing is that your problem is fixed
Yes, rep.2U2, Jupiter93: Thnx.4.d.fix: gonna try it quickly !
Thanks a lot! +rep!!!
EB II is finally out! ...NOW!!!...
Last edited by the man, the myth, the legend; June 22, 2013 at 07:11 PM.
The hardest thing in the world is to assume the mood of a warrior. It is of no use to be sad and complain and feel justified in doing so, believing that someone is always doing something to us. Nobody is doing anything to anybody, much less to a warrior. ― Don Juan
"It is the soldier, not the reporter, who has given us freedom of the press. It is the soldier, not the poet, who has given us freedom of speech. It is the soldier, not the campus organizer, who has given us the freedom to demonstrate. It is the soldier, who salutes the flag, who serves beneath the flag, and whose coffin is draped by the flag, who allows the protester to burn the flag." -- Father Dennis Edward O'Brien, USMC

subset: commoncrawl


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Represents the government, supporting Dutch nationals on wide ranging issues.See More
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A division of the Dutch Ministry of Economic Affairs for sustainable joint initiativesSee More
DRN is a business platform for Dutch entrepreneurs who maintain business contacts in Romania.See More
Premier English-language business publication for +18 years.
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Monthly business magazine. Exclusive regional content & Real Estate investment guide.See More
Leader in business-to-business and business-to-professionals communication in Romania.See More
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Lindsay C EdwardsAssociate Professor of Kinesiology College of Health Professions
- Bachelor of Science, Exercise Science (cum laude), Abilene Christian University, 1996
- Master of Science, Education, Tarleton State University, 1999
- Doctor of Philosophy, Kinesiology, University of Houston, 2008
Dr. Lindsay Edwards, is an Associate Professor in the School of Kinesiology, Health, and Recreation and serves as the graduate program director for the Master's degree in Kinesiology, Sport and Recreation. She received her Bachelors of Science degree in Exercise Science from Abilene Christian University, her Masters of Education from Tarleton State University and her Doctor of Philosophy degree in Kinesiology from the University of Houston.
She came to HSU in 2008 and currently teaches both undergraduate and graduate courses. She has many interests in Kinesiology, but her primary interest is in motor control and human performance. She works closely with undergraduate and graduate students on a variety of research projects, and desires to enrich student learning both in the classroom and online. She is currently a member of American College of Sports Medicine (ACSM) and the Christian Society for Kinesiology, Leisure and Sports Studies (CSKLS).


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I noticed that there are many Bahamians who tend to shy away from scientific subjects such as biology, chemistry, and physics in high school, and then struggle severely with them in college (when they choose to do science-based majors).
But the question is, why?
Is it because of religious reasoning? Is it because the older generation tend to make science seem hard and that only the intelligent can manage with it? is it just too elusive when taught in schools?
Well, I have my own ideas on how this could be the case:
1. Science and religion don't really get along too well– Science is based on pure facts that can be measured, justified and experimented on to get the same results while religion is based on faith (believing in things that you cannot perceive nor quantify in the natural realm). As you can see, the two are seemingly contradictory, which makes it difficult for the average Bahamian to accept one or the other, especially since The Bahamas considers itself a 'Christian nation.' Many Bahamians feel that exploring a science can 'test their faith.'
2. Asking questions is taboo– Many black Bahamians (well I find that this occurs throughout the African diaspora) tend to teach their children that questioning authority is wrong, including God. Science, on the other hand, questions everything, even the very existence of God. Again, both are seemingly contradictory.
3. Lack of role models– We are having a serious brain drain problem in which educated Bahamians (especially those that are great in research) are forced to find jobs to support their career goals elsewhere in the world simply because the older Bahamians don't accept/understand concepts that they were never introduced to. In other words, the older generation is vastly afraid of change and are too complacent to accept any new ideas that might rock their boats for the first few years of its implementation. Thus, many young Bahamians don't see that strong research component represented. The only scientific fields that are represented are medical (physicians or nurses) and maybe pharmaceuticals
4. The information presented seems hard to understand– science can become very complex the deeper you get into it. If you don't understand the basics very well, it will be extremely hard to understand more complex topics such as organic chemistry and biochemistry.
There may be a few other reasons that are not listed here (if you have some ideas, please place them in the comment section below). However, the average Bahamian need not be afraid or trepidatious when it comes to science and research because each country needs its own groups of researchers that will help it to succeed. It's how most first world countries become first world countries. Also, not everything that works for other countries will work for our own, thus we need unorthodox forward-thinking individuals and this is something that must be instilled within our kids from a young age.
Here's why.
Learning science encourages interest in research
One of the things that we have to stop doing to our kids, especially in the black community, is forbidding them from asking questions. We should allow their curiosity to be peaked and try to answer as best as we can. And for those answers that we don't know, encourage them to do their own research.
This is what science is. Asking questions and conducting research to try to find an answer to those questions. By asking questions, we are allowing our minds to venture off outside of the box. We need this in Bahamian society.
There is also this fallacy that many Christians love to purport which is, "God doesn't want us to ask Him questions." This could not be further from the truth. There were so many prophets, Kings and others who asked questions that God actually provides the answer for. In fact, many of them challenged God to prove his power, authority and even His promises of which He obliged (see Gideon, Abraham, Jonah, Moses, Jeremiah, Simon Peter, even Jesus to an extent, just to name a few). There is no excuse for us as human beings to not ask questions.
Learning science encourages critical thinking
When you are allowed to ask questions and you then research the answers, you start to relate commonalities between uncommon things and are able to decipher between what is useful and what is pure garbage.
Our Bahamian populace lacks this quality immensely and it is crippling us as a country, on the whole, affecting all areas from politics to education.
I am also quite aware that there are millions of people in first world countries that lack this quality as well. However, the reason why they thrive so well and for so long is because science is encouraged through STEM programs and science fairs/competitions in schools. This encouragement stems from the need to survive centuries of existential crises such as wars, viral/bacterial epidemics, famine, and drought.
The Bahamas, in its entirety, hasn't had a need to fight in a war since the American War of Independence of 1776 which means that we never really had to fight for survival in that sense. We just depended upon our first world counterparts for answers, protection, and money. We are also at a disadvantage because these countries have millions of people whereas we only have around 400,000 citizens. But this is exactly where we can shine.
Learning science should not disrupt religious beliefs
In fact, it should magnify it. I do identify myself as a Christ lover (as you can tell by the slightly biased imagery and tone of this article haha) and through science, I've come to understand the beauty and complexity of the world that He created. Do you know that with all the knowledge that we have today, it only just scratches the surface?
There is just wayyyyy too many things that science can't answer yet and it will take some thousands of years before it is able to access the meat of how our world/universe works. Thousands. That in and of itself is amazing.
Now, there are a lot of scientists who lose their faith in religion because they become too logical; they are constantly looking for answers and proof of their answers. And truth be told, a lot of these answers cannot be easily found in religion as it is a personal and spiritual relationship with an unseen being (in most cases). But if you really believe that there is a divine being then you should not feel threatened in any way as you start to learn and explore more about the world.
I can't speak for any other religion, but in Christianity, the Bible teaches us to seek knowledge first from our heavenly creator by reading the bible. He also wants us to understand the world around us because we are living in it for a short time. God also wants us to ask for wisdom and He will freely give it to us. Contrary to popular belief, God doesn't withhold anything from us. He just waits for the best time to reveal it.
Science is a necessity. Not an option.
It's how surgeons learn how to operate on you precisely. Its how pharmaceutical companies create medication to heal (or at least ease) some of the most terrible illnesses. It's how we can use the very device that you are using to read this article right now. Its how we are able to consume the foods we like year-round. Its how we are able to drink the drinks we like and also have the ability to taste other types of distilled water. It's how we are able to travel via car, boats, planes, and trains on a day to day basis. Its how we build our homes, offices and other structures. It's how we understand music.
Science is all around us. It's time for us Bahamians to take it seriously.


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The Hinayana View
The Hinayana View
The Path of The Noble Ones
Feb 17, 2020, 7:00 pm - 8:30 pm
Buddhism is not a religion in the usual sense of the word. It is a method of investigation that allows you to work skillfully with the positive potentials and negative energies of your own mind. The teachings of the Hinayana represent the most fundamental instructions of the Buddha, which are central to everything that follows. Hinayana studies, therefore, are basic to any training in Buddhism.
In the Nalandabodhi Path of Study, Hinayana studies introduce you to Buddhism as a science of mind, or method of investigation. Your study of the Hinayana continues for one year, divided into two courses: The first course covers the ground or view of Hinayana, and the second covers the Hinayana path and its results.
The Hinayana View (HIN 201)
Mondays, February 3 to March 23, 2020
No class on February 24th—Losar
This course introduces you to the Hinayana as the indispensable foundation of the three-yana system of Buddhist study (Hinayana, Mahayana and Vajrayana). Then you will learn the main elements of the Hinayana view, through a detailed examination of the building blocks of the Buddhist science of mind.
Prerequisite: Introduction to Buddhism
The text for the course is available in the Nalanda bookstore, which is open on Sundays noon to 1 pm and 6:30 – 7:30 pm on Monday, February 3rd and 10th.
Path of Study coordinator: Susan Kirchoff email@example.com
Enrollment includes access to the webcast of each class session, as well as recordings of the webcasts.


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Lynn Hung Finds Freedom After Heartbreak
By katrine on May 13, 2013 in NEWS
Since announcing her breakup with Aaron Kwok (郭富城), Lynn Hung (熊黛林) has been riding an emotional roller coaster as she mourned their 7 years together. While Aaron continued his work in high spirits, Lynn was slow to recover, often appearing tearful at public events. Now, nearly a month after their breakup was made public, Lynn is ready to put her past behind. The model spoke candidly about her time with Aaron, and shared how that experience forever changed her perspective on love and life.
Always close with her mother, Lynn flew home to Nanjing, China over the weekend to celebrate Mother's Day. She posted several photos with her mother on Weibo, looking content and relaxed while surrounded by friends and family. Lynn accepted interviews with mainland reporters during her trip, and spoke about the hardships she faced while dating a megastar. "Over the past few years I have lived in the public eye. Sometimes it is very difficult for me. I think from now on I won't have to force myself to do what I don't like, and instead focus on making myself and others happy."
Lynn shared that she used to dream about her wedding and wanted it to be perfect. "I wanted everything to be beautiful. Not just me, but him too, [I wanted] him in the perfect suit, waiting for me [at the end of the aisle]." Heartbreak has taught Lynn a harsh life lesson however, replacing her dreams with fear. "I'm afraid to hope. When you have hope, the disappointment is worse. From now on, I will focus on my career. Without a career, I will have no family." Despite dashed dreams, Lynn expressed that she is ready for her new life, and hopes to meet new friends and go on new adventures.
Meanwhile, Aaron maintained his good mood while dining with his mother this Mother's Day. He happily signed autographs for fans and waved to reporters as he escorted Mrs. Kwok on their night out. Aaron shared that he had prepared a special gift for his mother but kept mum on what it is. When reporters asked Mrs. Kwok to comment about spending Mother's Day this year without Lynn, Aaron immediately cut the question off, saying, "Don't ask about this, okay?"
Source: Oriental Daily
This article is written by Katrine for JayneStars.com.


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I woke up on Sunday morning thinking- I want to look cute today. I reached in my closet for this adorable vintage dress with the cutest red bow! This black dress fits nicely and does have some stretch to it. My only issue is at the top of the shoulders, it kept giving this pointed look. I did have a slight wardrobe malfunction with my bra strap during this shoot, but I think everything worked together.
Other than that, the fabric is really nice and the bright red bow added that pop of color that I always try to find in each outfit I put together. I added a little pill box hat to really send my cuteness radar over the top. I did a simple winged liner and red lipstick for my makeup, and accessorized with an oversized hand bag and pearl jewelry.
Outfit Details: Black Vintage Style dress | Shoes | Bag | Hat | Pearl bracelet (Similar) | Pearl Earrings


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Buddle Findlay was on a mission to find talented law clerks at the top of their game for a summer internship programme.
The problem was every other law firm was looking too, so we needed to deliver an extra bold recruitment campaign that would make our client stand out.
Graduates are fearless in their naivety – the world is their oyster. You could say anything's possible, so we wanted to get their imaginations racing by challenging them to 'Imagine the possibilities'.
This was a concept interpreted visually as a series of surrealist mash-ups on sweet, sticky, pastel backgrounds that felt bright, curious and playful. A woman on a bumble bee; a puppy with wings; a child swinging from a cloud. We chose the typeface, Cumulus & Foam, as the perfect typographical expression of this concept, given its hint of Dada and the surreal.
These images formed the basis for a series of street posters that appeared throughout campuses in Auckland, Wellington and Christchurch.
Posters as well as advertising drove traffic to a microsite where applicants could find out more about previous summer clerks and kick-off their application process. These were supported by banners and post cards at recruitment open days.


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AP: Starbucks to close stores for bias training
Starbucks says it will close its more than 8,000 U.S. stores for several hours next month to conduct racial-bias training to its nearly 175,000 workers.
This announcement comes amid calls for a boycott of the stores after two African-American men were arrested in Philadelphia Starbucks. A company representative said the Starbucks corporate offices will be closed as well.


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In the data series window, if you make your candle body outline color setting to
transparent, doji bars ( a bar with the same open and close) will not display its open or close. The candle will only show the range of high to low without displaying where the candle opened and closed. I'm hoping you can fix this issue with the transparent candle body outline color setting.
I have attached two of the same charts with different colors. The example doji is about the fourth bar from the start of july. Open the white background chart first before opening the black background chart.
thank you


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Hispanic TV Summit: Reaching Moms and 'La Familia'
Since the early 1960s, Procter & Gamble has developed and supported outreach and grassroots programs to enrich the lives of U.S. Hispanics.
Such initiatives provide an opportunity to connect with consumers who may find themselves "in a new country, a new environment [and] who may not be familiar with our brands," said P&G general manager of North America branding Edgar Sandoval.
One of these has been the hugely successful Todobebe program, part of the P&G-sponsored "Viva La Familia" campaign, in which Hispanic moms win merchandise for an in-home fiesta.
"With the future birth rate in the U.S. being so significantly driven by Hispanics, we've got to win with mom — mom is No. 1," Sandoval said. "We try to reach out and meet her on her terms, in her home, in the context of her life."
Earlier this year, P&G and its Tide brand hosted the "Tide Values Mom" event, designed to thank moms for all their hard work and for taking care of their families.
Mexican singer and actress Angélica María, known as "La Novia de America" ("America's Sweetheart") celebrated Mother's Day by serenading women at Los Angeles-area laundromats over the course of two days.
As part of the celebration, Tide also ran a sweepstakes for area mothers to win a dinner with María.
"We believe this consumer is very discerning, very smart," Sandoval said, and these programs afford P&G the opportunity to "spend a lot of our time just sharing with them what our brands and our products can do for them. We believe that if we do that, they will choose us, because they're looking for value and that's what we provide."


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This post is sponsored by Horizon Organic, all opinions are my own. Kids Build Their Own Organic Lunch Routine: Take the hassle out of lunch prep with a routine that allows kids to make their own lunches by selecting from a variety of organic ingredients that are mom approved–like Horizon Organic. As a mom, one...Read More »
This instant pot cashew chicken tastes like the familiar Chinese takeout we all love, but in a better-for-you, Whole30, Paleo, gluten-free version that only takes 30 minutes. No... Read More
Mushroom and Kale Lasagna Roll Ups in Creamy Gorgonzola Cauliflower Sauce Recipe : Mushrooms, kale and cheese all rolled up in lasagna noodles, smothered in a creamy gorgonzola cauliflower sauce and cheese and baked until all melty, golden brown and good.
Banana Muffins | Grain-free and Egg-free | Ponderings From My Heart | Ponderings From My Heart
This Healthy Breakfast Muffins Recipe for Toddlers tastes delicious and is jam-packed with spinach, bananas and other nutritious ingredients.
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The Master's Learning Institute
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Although our church has an accreditation committee that oversees our schools and we are inspected yearly for compliance with the state of Texas as a Non-Traditional Secondary Educational Program. We do not declare that we are accredited because it might be misconstrued as being accredited thru TEA or TEPSAC. We are not. We are Not State or Federally Funded , and do not have to be accredited as a Home School Service/Program in Texas.
In fact our students in many cases are more accepted as a Home School Graduate than any other Private School or Accredited status. You are not required by law in the State of Texas to be accredited. We have a strong Home School Lobby in Texas for Home School Students who choose a Non-Traditional way of becoming educated. We have declared our independence since 1986, and will remain Independent to protect those who choose to have a Godly Education in the State of Texas and Nationwide. Hundreds of our students have accomplished the needs and dreams of a lifetime thru the High School Diploma and Transcript The Masters Learning Institute provides. It is important to note that The Master's Learning Institute also requires each student to provide an SAT/ACT testing score to apply to institutions of higher learning, Vocational School, Military Branch, or University. These scores serve as a recognized State Scored test and will support the Diploma Certificate received by MLI. We pray to always remain Independent and be of service to those who choose The Master's. May God Bless your educational Journey.
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Purpose: We sought to determine whether the −6 exon 13 T>C polymorphism in the DNA mismatch repair gene hMSH2 modulates susceptibility to acute myeloid leukemia after therapy and particularly after O6-guanine alkylating chemotherapy. We also determined the extent of microsatellite instability (MSI) in therapy-related acute myeloid leukemia (t-AML) as a marker of dysfunctional DNA mismatch repair.
Experimental Design: Using a novel restriction fragment length polymorphism, verified by direct sequencing, we have genotyped 91 t-AML cases, 420 de novo acute myeloid leukemia cases, and 837 controls for the hMSH2 −6 exon 13 polymorphism. MSI was evaluated in presentation bone marrow from 34 cases using the mononucleotide microsatellite markers BAT16, BAT25, and BAT26.
Results: Distribution of the hMSH2 −6 exon 13 polymorphism was not significantly different between de novo acute myeloid leukemia cases and controls, with heterozygotes and homozygotes for the variant (C) allele representing 12.2 and 1.6%, respectively, of the control population. However, the variant (C) hMSH2 allele was significantly overrepresented in t-AML cases that had previously been treated with O6-guanine alkylating agents, including cyclophosphamide and procarbazine, compared with controls (odds ratio, 4.02; 95% confidence interval, 1.40–11.37). Thirteen of 34 (38%) t-AML cases were MSI positive, and 2 of these 13 cases were homozygous for the variant (C) allele, a frequency substantially higher than in the control population.
Conclusions: Association of the hMSH2 −6 exon 13 variant (C) allele with leukemia after O6-guanine alkylating agents implicates this allele in conferring a nondisabling DNA mismatch repair defect with concomitant moderate alkylation tolerance, which predisposes to the development of t-AML via the induction of DNA mismatch repair-disabling mutations and high-grade MSI. Homozygosity for the hMSH2 variant in 2 of 13 MSI-positive t-AML cases provides some support for this model.
t-AML3 was initially recognized >30 years ago in patients treated for multiple myeloma with melphalan (1) . t-AML has since been reported subsequent to numerous primary malignancies, including Hodgkin's disease, non-Hodgkin's lymphoma, breast cancer, ovarian cancer, and testicular cancer (2, 3, 4, 5, 6, 7) . This devastating condition now represents up to 10% of all AML cases.
The clinical characteristics of t-AML differ according to the nature of the therapeutic exposure. After treatment with DNA topoisomerase II inhibitors such as epipodophyllotoxins, t-AML has a relatively short latency period (typically up to 2 years) often with no preleukemic phase and is associated with translocations involving the MLL gene at 11q23 (8) . In contrast, t-AML after treatment with chemotherapeutic alkylating agents such as nitrogen mustards, nitrosoureas, platinum-based compounds, and hydrazines is characterized by a longer latency period (up to 10 years) often presenting with myelodysplasia and is associated with loss or deletions of chromosome 5 and/or 7 and p53 mutations (9 , 10) . These observations suggest multiple genetic mechanisms by which t-AML may arise. The prevalence of MSI suggests that dysfunctional DNA mismatch repair may be one such mechanism of malignant transformation in t-AML (11) .
The primary function of DNA mismatch repair is to correct replicative errors that escape DNA polymerase proofreading. In humans, the MutSα complex (composed of MSH2 and MSH6) and the MutSβ complex (MSH2 and MSH3) recognize and bind to single base mismatches and insertion/deletion loops in DNA (12 , 13) . Subsequent recruitment of MutLα (MLH1 and PMS2) facilitates degradation and resynthesis of the mispaired region in the newly synthesized daughter strand (14) . Although defects in any of the proteins can impair the DNA mismatch repair system, the process is most greatly affected by abnormal MSH2 or MLH1 function (15 , 16) . Cells manifesting mutations as a result of dysfunctional mismatch repair are described as having a mutator phenotype. In human studies, the mutator phenotype has been demonstrated in a variety of sporadic cancers and inherited conditions, including HNPCC (17) , and is associated with the presence of extensive MSI. Microsatellites are short, often polymorphic repeat sequences dispersed throughout the genome. Alterations in microsatellite length occur because of errors in replication, and instability at these sites is indicative of defects in DNA mismatch repair. MSI in hematological disorders is rare, but it has been observed in acute leukemia, including t-AML. Although Ben-Yehuda et al. (11) reported MSI in >90% of t-AML and t-MDS patients, subsequent studies have reported a lower incidence in t-AML (up to 50% of cases; Refs. 18, 19, 20, 21 ). Generally, the reported incidence of MSI in de novo AML (0–30% of cases) is comparatively lower than in t-AML (18 , 20 , 21) . Critically, abnormal MSH2 expression has been reported in microsatellite unstable AML, including t-AML (19) , providing additional evidence for dysfunctional mismatch repair in these cases.
Exon 13 of hMSH2 is located in the most conserved region of the gene and encodes part of the DNA binding domain (22 , 23) . Previous studies have identified a T>C transition polymorphism at position −6 of the 3′ splice acceptor site of exon 13 (22 , 24) . Polymorphisms within the 3′ splice junction consensus sequence between +1 and −16 may alter the efficiency of RNA splicing (25) . The −6 exon 13 polymorphism lies within a short poly(T) tract forming an atypical 3′ splice acceptor sequence, which may weaken splice site recognition. The location of the −6 exon 13 T>C polymorphism has led to suggestions that the variant hMSH2 sequence may result in alternatively spliced mRNA. Although this has been reported (26 , 27) , including transcripts lacking exon 13, there appears to be no relation with the −6 T>C exon 13 polymorphism (26 , 28) . Thus, the functional significance of the hMSH2 −6 exon 13 polymorphism remains unclear.
Fishel et al. (22) observed heterozygosity for the −6 exon 13 transition polymorphism in the germ-line of affected individuals, but not unaffected individuals, from two chromosome 2-linked (hMSH2) HNPCC families, although this association remains unconfirmed. Subsequent studies have reported a significant association between heterozygosity for this polymorphism and susceptibility to sporadic colon cancer (24 , 26 , 28) . In hematological studies, the −6 exon 13 transition polymorphism has been shown to be prevalent among human precursor T-cell lymphoblastic lymphoma cases (23) . Also, the variant allele has been significantly associated with non-Hodgkin's lymphoma (29) .
The low frequency of the hMSH2 T>C splice acceptor polymorphism has precluded analysis of any potential disease association in the homozygous state. In this study, we have determined the distribution of the hMSH2 T>C −6 exon 13 polymorphism in a case-control series of 420 de novo AML cases and 837 matched unaffected controls. We have also determined genotype distribution in a case series of 91 individuals with t-AML. Where possible, MSI was also analyzed in corresponding samples as a marker of dysfunctional DNA mismatch repair and related to hMSH2 genotype and therapeutic exposure leading to t-AML.
Genotyping for the −6 Exon 13 Polymorphism
The hMSH2 −6 exon 13 polymorphism has been examined in three groups of subjects; there were 91 t-AML cases, 420 de novo AML cases, and 837 unaffected controls (Table 1)⇓ . For this study, t-AML is defined as AML after chemotherapy and/or radiotherapy diagnosed at least 2 months after the start of the initial cytotoxic therapy. All de novo AML cases, unaffected controls, and 24 t-AML cases were obtained as part of a United Kingdom population-based case-control study of adult acute leukemia that has been described elsewhere (30) . Genotyping was performed using DNA extracted from presentation peripheral blood for all de novo AML cases and 24 t-AML cases. DNA extracted from presentation bone marrow was used for genotyping the remaining 67 t-AML cases. We acknowledge the remote possibility that blast contamination of peripheral blood or bone marrow samples may cause misgenotyping because of allelic loss in blast cells, which may cause a heterozygote to appear as a homozygote. However, we feel that this would be extremely unlikely for two main reasons: firstly, chromosome 2p (hMSH2) is rarely affected by deletion or any aberration in AML; secondly, even in patients with a high presentation blast content, we feel it is extremely unlikely that a peripheral blood or marrow sample would be completely devoid of normal constitutive DNA.
Additional DNA samples were obtained from 67 subjects with t-AML enrolled in the MRC AML trials 10, 11, and 12 (31) . Eighty-nine of the 91 t-AML cases have been described in detail elsewhere (32) . The remaining 2 t-AML cases were both female ages 55.4 years (FAB type M2) and 57.5 years (FAB type M5) at diagnosis of t-AML (and both had received radiotherapy only for a previous condition). Cytogenetic analysis was successful for the younger case only [50, XX, +8, +14, +21, +22 (Ref. 9 )/46, XX (Ref. 1 )]. All 420 de novo AML cases, 837 controls, and 69 of 91 t-AML cases were confirmed as United Kingdom Caucasians. Ethnicity data on the remaining 22 t-AML cases were not available. However, because the United Kingdom population is composed predominantly of Caucasians, it remains likely that most, if not all, of the remaining 22 t-AML cases were Caucasian. All 16 t-AML cases previously exposed to O6-guanine alkylating agents were confirmed as United Kingdom Caucasians. All subjects taking part in the Leukaemia Research Fund acute leukemia case-control study and the MRC AML trials 10, 11, and 12 gave informed consent.
hMSH2 Genotyping by RFLP-PCR.
Forward (5′-TGTGGGCAGGCTGTGGTTC-3′) and reverse (5′-CTCCCATATTGGGGCCTGCA-3′) primers were used to amplify the hMSH2 sequence flanking the −6 exon 13 polymorphism. The reverse primer was designed with a mispaired base at position 18 (corresponding to position −3 of exon 13) generating an artificial PstI restriction site upon amplification of the variant allele only (Fig. 1)⇓ . PCR amplifications were performed using 0.5 units of AmpliTaq Gold (Perkin-Elmer), 10 pmol of each primer, 200 μm of each deoxynucleotide triphosphate, and 1.5 mm MgCl2 in a 20-μl reaction mix containing 1× PCR reaction buffer and ∼50 ng of template DNA. PCR conditions were as follows: cycle 1, 15 min at 95°C; cycles 2–37, 1 min at 95°C; 1 min at 64°C, followed by 1 min at 72°C; and cycle 38, 10 min at 72°C. PCR products were digested with 20 units of PstI (New England Biolabs) at 37°C for 4 h. Digestion products were separated on a 3% agarose gel and visualized against a 100-bp ladder (Fig. 1)⇓ .
DNA Sequencing.
To confirm that the RFLP-PCR was discriminating between polymorphic hMSH2 alleles, 60 samples were sequenced (14 TT homozygotes, 25 heterozygotes, and 21 variant CC homozygotes, as determined by the RFLP-PCR method). Firstly, DNA was amplified using forward (5′-GCAGGCTGTGGTTCTGCT-3′) and reverse (5′-TTGATTTACCTCCCATAT TGGG-3′) hMSH2 primers flanking the −6 exon 13 polymorphism, using the reaction condition described above at an annealing temperature of 60°C. Amplification products were then sequenced using the AmpliTaq Big Dye terminator cycle sequencing kit (Applied Biosystems). Sequencing electrophoresis was performed on the ABI Prism 377 sequencer, and results were analyzed using the ABI Prism 377 software. Of the 60 samples analyzed, 58 of the DNA sequencing results correlated with RFLP-PCR genotyping, confirming that the RFLP-PCR can discriminate between wild-type and variant alleles with a minimal error rate (3%). In both discrepant cases, heterozygotes by RFLP were subsequently sequenced as homozygotes (1 TT and 1 CC). Thus, to minimize the error frequency, all heterozygotes and homozygotes for the variant (C) allele and all t-AML cases irrespective of status were genotyped at least twice. In a few samples, a third assay was performed if the first two assays gave discrepant results. Thus, the final genotyping error frequency is likely to be <3%.
Statistical Analysis.
ORs and 95% CIs, adjusted for age and sex, were calculated using unconditional logistic regression (33) . hMSH2 genotype was analyzed as a trichotomous (TT, TC, CC) or dichotomous (TT, TC + CC) variable. All analyses were conducted using Stata 1999 (Stata, College Station, TX).
Presentation bone marrow samples were available for 46 cases (Table 1)⇓ , including 34 cases of t-AMLs and 12 cases of t-MDSs. Twenty-six of the t-AML cases were of United Kingdom origin and were part of the case series genotyped for the −6 exon 13 hMSH2 polymorphism. The blast content in bone marrow samples from 19 of the t-AML cases was ≥40% (median of 70%). Data regarding blast content was not available for the remaining 7 samples. Although leukemic blasts could not be separated from normal cells, a previous study shows that MSI can unambiguously be detected in samples containing low amounts of leukemic blasts (34) . The remaining 8 t-AML and 12 t-MDS cases were of Finnish and North American origin and were included in prior epidemiological studies (5 , 6 , 10) . One of the t-AML cases was male who had previously received chemotherapy for testicular cancer. The remaining t-AML and t-MDS cases were all female and had received platinum-based chemotherapy for ovarian cancer before diagnosis of t-AML or t-MDS. Data regarding blast content was available for 2 of the t-AML cases (40 and 50%) and 3 of the t-MDS cases (16, 15, and 11%) within the non-United Kingdom patient series.
Two mismatch repair-proficient (TK6 and SW480) and three mismatch repair-deficient (LoVo, MT1, and HCT116) human cell lines were used as negative and positive controls for MSI, respectively. LoVo and HCT116 have both alleles deleted for hMSH2 and hMLH1, respectively (35 , 36) , whereas MT1 is mutated in both copies of hMSH6 (37) . DNA samples extracted from the peripheral blood of 29 subjects known not to have a malignant condition were used as controls (Table 1)⇓ .
Analysis of MSI.
Primer pairs were synthesized using previously published sequences for BAT25 (chromosome 4q), BAT26 (chromosome 2p), and BAT16 (chromosome 7p) (38) . One primer of each pair was 5′-end labeled with 6-carboxyfluorescein. PCR amplifications were performed using 0.5 units of TaKaRa LA TaqDNA polymerase (Takara Biomedicals, Shiga, Japan), 10 pmol of each primer, 0.4 mm of each deoxynucleotide triphosphate, and 2.5 mm MgCl2, using ∼50 ng of template DNA in a 50-μl reaction containing 1× PCR reaction buffer. PCR conditions were as follows: cycle 1, 10 min at 94°C; cycles 2–37, 1 min at 94°C, followed by 1 min at 56°C for BAT16 or 55°C for BAT25 and BAT26 and then 1 min at 72°C; and cycle 38, 10 min at 72°C. Amplified PCR products were analyzed using an automated 373A DNA sequencer (Applied Biosystems), and results were analyzed using the Applied Biosystems Genescan software in accordance with manufacturers instructions. All three mononucleotide markers are quasimonomorphic, eliminating the requirement for constitutional DNA (38, 39, 40) . MSI was diagnosed as the presence of a clearly discernable peak not present in the control population, as illustrated in Fig. 2⇓ . Normal cells could not be separated from blast cells and so a peak representing the stable constitutive alleles was always seen in the t-AML case DNA. In contrast, the mismatch repair defective cell lines LoVo and MT1 displayed only a single unstable peak (Fig. 2)⇓ . All t-AML and t-MDS cases for whom bone marrow was available were examined for MSI at all three loci.
Distribution of the hMSH2 −6 Exon 13 Polymorphism in de Novo AML and t-AML.
The hMSH2 T>C polymorphism at the −6 position of the splice acceptor site of exon 13 was not significantly associated with de novo AML (Table 2)⇓ , although the de novo AML case series has a marginally higher percentage of individuals heterozygous and homozygous for the lower frequency variant (C) allele (15.7%), compared with controls (13.8%; OR, 1.17; 95% CI, 0.83–1.64; Table 2⇓ ). hMSH2 polymorphic status was not associated with gender in either the control or de novo AML case series (data not shown) or with cytogenetic subgroup in the de novo AML case series (data not shown).
MSH2 is known to modulate apoptosis in response to alkylating agents, including several chemotherapeutic alkylating agents, and in particular those that alkylate the O6 position of guanine in DNA (41 , 42) . The t-AML case series described in this study has a high proportion of individuals whose leukemia developed subsequent to chemotherapeutic alkylating agents (32) . Individuals heterozygous or homozygous for the hMSH2 variant allele were nonsignificantly overrepresented in the chemotherapy-related t-AML case-series, compared with controls (OR, 1.56; 95% CI, 0.75–3.21; Table 2⇓ ). Sixteen of 91 t-AML cases had documented previous treatment with chemotherapeutic O6-guanine alkylating agents, which included procarbazine, dacarbazine, 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea, and cyclophosphamide. Consistent with a role in conferring susceptibility to O6-guanine alkylating agent-induced myeloid leukemia specifically, 6 of these 16 (37.5%) cases were carriers of at least one variant hMSH2 allele, a frequency significantly higher than in both the control series (13.8%; OR, 4.02; 95% CI, 1.40–11.37; Table 2⇓ ) and the de novo AML cases series (15.7%; OR, 3.10; 95% CI, 1.08–8.89). In contrast, 4 of 34 (11.8%) cases who received chemotherapy that did not include an O6-guanine alkylating agent were carriers of at least one variant hMSH2 allele, a frequency not significantly different from either the controls (13.8%) or the de novo AML case series (15.7%).
MSI in t-AML.
To investigate whether DNA mismatch repair dysfunction may be a characteristic feature of our t-AML case series, we examined three quasimonomorphic mononucleotide microsatellite markers for instability (BAT16, BAT25, and BAT26). These markers were chosen because they have been shown to be unstable in hereditary and sporadic colon cancer and some hematological malignancies (11 , 40 , 43 , 44) . Two of these markers, BAT25 and BAT26, are recommended for MSI analysis by the International Collaboration Group for HNPCC (40) . Furthermore, in a study of 44 microsatellite markers and 107 colon cancers, Halford et al. (45) demonstrated that instability at BAT25 and BAT26 is 99 and 98% specific, respectively, for high-grade MSI (where >30% of all markers are unstable) and is indicative of DNA mismatch repair dysfunction.
MSI was detected in 13 of 34 (38%) t-AML cases for whom presentation bone marrow was available (Fig. 3⇓ , Table 3⇓ ). In 12 of 13 MSI positive t-AML cases allelic shortening was found at BAT25 (Figs. 2⇓ and 3⇓ ). Two samples displayed instability at BAT26, one of which was also unstable at BAT25 (Table 3)⇓ . Allelic shortening at BAT25 and BAT26 varied between 5 and 9 bases and 3 and 4 bases, respectively, consistent with published data (38 , 39) . MSI was not detected at BAT16 in any of the t-AML samples investigated. MSI was not detected at any locus in any of the 29 control DNA samples investigated or in either of the 2 DNA mismatch repair-proficient cell lines (TK6 and SW480) investigated. In contrast, MSI was detected in all three DNA mismatch repair-deficient cell lines. LoVo displayed MSI at BAT25 and BAT16. Amplification at BAT26 was not possible because of biallelic deletion. MT1 and HCT116 were both unstable at BAT25. MT1 was also unstable at BAT26. Instability was not detected at any of the three markers investigated in any of the 12 t-MDS cases.
MSI and the hMSH2 −6 Exon 13 Polymorphism in t-AML.
All 13 MSI-positive t-AML cases were of United Kingdom origin and were genotyped for the hMSH2 −6 exon 13 polymorphism. Three of the 13 (23%) MSI-positive t-AML cases were carriers of at least one variant hMSH2 allele (Table 3)⇓ , and 2 of these 13 cases (15.4%) were homozygous for the variant hMSH2 allele, a frequency considerably higher than in both the control population (1.6%) and de novo AML case population (2.5%). One case (case 56) had been treated with alkylating agent-based chemotherapy and radiotherapy for Hodgkin's disease (Table 3)⇓ . The other case (case 68) had been treated with 5-fluorouracil and radiotherapy for colorectal cancer (Table 3)⇓ . Of the remaining 21 MSI-negative t-AML cases for whom presentation bone marrow was available, 13 were of United Kingdom origin and were genotyped for the hMSH2 −6 exon 13 polymorphism. Twelve of these 13 cases were homozygous for the common (T) allele, whereas the remaining case was heterozygous (data not shown). Thus, in the MSI-negative t-AML case population, the frequency of individuals with at least one copy of the variant hMSH2 allele (7.7%) was not significantly different to either the control (13.8%) or the de novo AML case population (15.7%).
A causal role for chemotherapeutic alkylating agents in t-AML etiology is well established. Furthermore, DNA mismatch repair status modulates apoptosis in response to alkylating agents, where loss of functional DNA mismatch repair confers tolerance to the apoptotic effects of some alkylating agents, particularly O6-guanine alkylating agents (15 , 16 , 41 , 42) . DNA mismatch repair-defective cells have a concomitantly high rate of both spontaneous and alkylation-induced mutagenesis (42 , 46) . Thus, dysfunctional mismatch repair confers not only tolerance to the killing effects but also sensitivity to the mutagenic effects of alkylating agents, consistent with the acute susceptibility to alkylation-induced tumorigenesis in DNA mismatch repair-defective mice (47) . Our finding that the variant hMSH2 allele is significantly overrepresented in t-AML cases who specifically had previous treatment with chemotherapeutic O6-guanine alkylating agents is suggestive that this allele may confer moderate alkylation tolerance with concomitant susceptibility to t-AML. However, we cannot exclude the possibility that polymorphic hMSH2 may modulate susceptibility to the development of primary cancer or be involved in determining response to therapy for that cancer. Either of these may affect the prevalence of the hMSH2 polymorphism in the population at risk of subsequently developing t-AML.
The demonstration of MSI in 13 of 34 (38%) t-AML cases investigated confirms a role for compromised DNA mismatch repair in the pathogenesis of a subset of t-AML cases. These data are consistent with reports of MSI and aberrant MSH2 expression in other t-AML case series (11 , 19 , 21 , 43) . Furthermore, our data are consistent with that of Ben-Yehuda et al. (11) , Olipitz et al. (43) and Gafanovich et al. (44) , who also used the quasimonomorphic mononucleotide markers BAT25 and BAT26 and reported MSI at these markers in 30–60% of t-AML and t-MDS cases. Instability at these loci is highly predictive of extensive high-grade MSI (greater than 30% of marker instability; Ref. 45 ) and dysfunctional DNA mismatch repair and is very rarely seen in tumors that have low-level or no MSI (38 , 39 , 45) . Thus, the high specificity of BAT25 and BAT26 (99 and 98%, respectively; Ref. 45 ) for high-grade MSI demonstrates dysfunctional mismatch repair in a significant proportion of the t-AML cases described in this study.
The high sensitivity of BAT25 and BAT26 (78 and 90%, respectively; Ref. 45 ) to detect high-grade MSI and the relatively poor concordance between these two markers in our study suggests that in our hands, BAT26 is underestimating MSI. As such, we cannot exclude the possibility that we have not been able to detect high-grade MSI in t-MDS, as reported by others (43 , 48) , because of insensitive MSI analysis and low or undefined presentation bone marrow blast content.
Of the 13 t-AML cases with MSI, 9 had prior exposure to chemotherapy, predominantly alkylating agents and base analogues, and 4 had received radiotherapy only. Moreover, 3 cases had an apparently normal karyotype, whereas the remaining included cases with balanced and unbalanced aberrations, including 6 cases with chromosome 5 and/or 7 aberrations. Thus, the clinical and cytogenetic heterogeneity of the MSI-positive t-AML cases supports the notion of multiple pathways by which MSI may arise in t-AML and suggests a role in hematopoietic progenitor cells for DNA mismatch repair in mediating response to mechanistically diverse genotoxic agents. Consistent with this, deletion of Msh2 in murine stem cells confers tolerance to the killing effects of chemotherapeutic alkylating agents, chemotherapeutic base analogues, and ionizing radiation (49, 50, 51) . Our observations suggest a hypothesis whereby polymorphic hMSH2 weakly attenuates DNA mismatch repair function and confers moderate tolerance to the killing effects and concomitant susceptibility to the mutagenic effects of therapy, particularly O6-guanine alkylating therapy. As such, individuals carrying variant hMSH2 may be more susceptible to the induction of therapy-induced DNA mismatch repair-disabling mutations, giving rise to a true mutator phenotype and high-grade MSI. Homozygosity for the hMSH2 variant in 2 of 13 MSI-positive t-AML cases provides some support for this model.
We thank Rachel Clack (Clinical Trials Service Unit, Radcliffe Infirmary, Oxford, United Kingdom), William G. Thilly (Massachusetts Institute of Technology), David Swirsky (Hematological Malignancy Diagnostic Service, Leeds General Infirmary), and the staff of the Leukemia Research Fund Epidemiology and Genetics Unit at Leeds University for their expert assistance and provision of materials. We also thank Stephen Langabeer at the MRC DNA/RNA bank for his support, and University College London Hospital, a facility funded by the Kay Kendall Leukemia Fund.
The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
↵1 This work was funded by the Leukemia Research Fund of the United Kingdom (to G. J. M., E. R.) and by the Kay Kendall Leukemia Fund of the United Kingdom (to J. M. A.).
↵2 To whom requests for reprints should be addressed, at Epidemiology and Genetics Unit, Algernon Firth Building, School of Medicine, University of Leeds, Leeds LS2 9JT, United Kingdom. E-mail: jim{at}lrf.leeds.ac.uk
↵3 The abbreviations used are: t-AML, therapy-related acute myeloid leukemia; AML, acute myeloid leukemia; HNPCC, hereditary nonpolyposis colorectal carcinoma; MSI, microsatellite instability; t-MDS, therapy-related myelodysplastic syndrome; MRC, Medical Research Council; RFLP, restriction fragment length polymorphism; FAB, French-American-British; OR, odds ratio; 95% CI, 95% confidence interval.
- Received December 19, 2002.
- Revision received February 21, 2003.
- Accepted March 23, 2003.


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Cryptic Studios has released a trailer for their upcoming Star Trek online MMORPG and it looks awesome! See for yourselves:
You better believe I will be playing this game once it is released since according to info from mmorpg.com, you will be able to play a number of races including human, Vulcan, Andorian, Klingon, Orion, Gorn, and several others. You will also be able to create your own race with its own custom look and attributes. How freaking cool would it be to play a Gorn hunting down federation red shirts?
According to the info released by the game's creators, the game is set approximately 30 years after the events in Star Trek Nemesis. The game starts in 2409. Technology has advanced and the galaxy is a much more volatile place. Some of the ST games I've played recently haven't been very good, including Star Trek Conquest, so I have really high hopes for this one.
In other MMO news, I promised I would report back on whether LOTRO is worth your MMORPG subscription dollars. I would have to say yes, but don't expect it to be 100 percent like Wow. Yet, this is a fun game and even though I have only 2 days left of my 14 day trial, I am almost done with the introduction and have reached level 7 which is a drop in the bucket compared to some of these long time players. Then again, Unlike others, I don't have 12 or 16 hours to kill in front of a computer playing a game, I'm good for about 1 or 2 each night if lucky.
I could be wrong about this, but you have to have even finished the intro in order to activate the social panel and join a fellowship. The final quest in the intro has you following Dwalin and defending him inside Skorgrim's tomb. I took a cool screenshot of my character fending off a couple of goblins but then I got greedy and tried to capture Dwalin after he destroys a gate entrance. It's kind of too dark to see, but you can make him out saying, "Stand back now!"
The problem with defending Dwalin is despite his use of magic energies, he's a 5th level character and he's old, so I was like twice as powerful as he was, he held his own for awhile but when you're taking on 4 evil doers, he tends to get himself killed and you have to do the final quest more than once to complete it. I'm pretty sure I will be finishing it before the trial period ends though. So the final verdict?
Yes I would have to say that LOTRO is almost as fun or even more fun than DDO Stormreach (where you seem to fight a lot of Kobolds in the early levels) and though not as engaging as Wow, I only played one race, so maybe it would be fun to play other races.


text: Abstract: Animal tagging is a useful technique for studying wildlife and wild ecologies. The value of of these studies can be expanded by increasing the lifetime of the tag, which is usually limited by battery life. Therefore, technologies which reduce the overall power consumption of a tag have the potential to expand the scope and quality of ecological monitoring. One technique for reducing the power consumption of a tag is to augment the power source with on-board energy harvesters, which scavenge ambient energy from the animal or the environment. Another technique is to adaptively reduce the fraction of time that high-power sensors are active. The ESCAPE project attempts to design, implement, and test a variety of these techniques in collars for large terrestrial mammals. Our collars implement kinetic, thermal, and solar harvesters to reduce battery load. We also present three algorithms for using low-power accelerometery measurements t! o reduce the duty cycle of costly GPS measurements. This project includes an electronic design to integrate these techniques in compact, low-power circuit.


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We have a Fireteam of four this go-round as we gather on Discord to talk Destiny, mainly about the end of Season of the Worthy…and…Leave a Comment
Tag: podcast
Episode #60: Catching up with the Fireteam on the Guardian Games, the State of Content, and Cheating in Trials
Tee is taking the hit on this one. He has been working hard on a lot of various projects as you'll hear in the show…
Happy Reset Day! It's time to celebrate the Season of Dawn. What are you excited about? Share us your thoughts at 703.791.1701!Leave a Comment
After two months of quiet comms, the Fireteam returns with a two-part show this week all about Shadowkeep! Eyes up and enjoy the ride!Leave a Comment
We are back for another episodes, this time with a full Fireteam. Good thing this worked out, too, as we are both talking about Season…Leave a Comment
EDITOR'S NOTE: During the playback of the episode, we have noticed some problems with "crackling" in the audio. Turns out a cable (we're just not…Leave a Comment
After another round of setbacks in January, we're back and kicking off 2019 with a video episode. This gameplay breakdown features Destiny 2: Forsaken's popular…Leave a Comment
The Festival of the Lost has come and gone. Our Guardians had varying experiences. Tee and Nick loved the Haunted Forest, while Ron just couldn't…Leave a Comment
Refer-a-Friend, Enhancement Cores, a Costume Contest and more! October 30th brings the weekly Tuesday reset to Destiny 2 and with it the 2.0.5 version of…Leave a Comment
It's spoopy time, Guardians! Once again, the players of Destiny 2 will head into a Halloween (ish) event, but this time, there's more to do…1 Comment
It's that time again. The good folks at Bungie have relayed their reactions to the community and game play experience. For many of us, it's…1 Comment
August has come and gone, and with it the final This Week at Bungie (TWAB) before we all embark on the Forsaken expansion. We've been…Leave a Comment
Well, we finally did it. We caved to Tee's burning desire to record an episode live on Twitch. Join Tee, Nick, Brandon and Ron as…Leave a Comment
Yes, it has been a bumpy summer between Man Flu, Day Job demands, and overall Life getting in the way; but WE ARE BACK!!! You…2 Comments
Thursday, June 28th brought us the most recent "This Week at Bungie" (TWAB) from the creators of Destiny. Nothing can hit the player community as…Leave a Comment
Return to Warmind! You heard us rave about Warmind two weeks ago, and here we are a month later, and we just can't get enough!…Leave a Comment
This is probably one of the goofiest shows we have ever recorded. This means you should kick back and enjoy the listen. We're just having…Leave a Comment
Listen to Parts 1 & 2 of Omens here! Listen to Parts 3 & 4 of Omens here! Listen to Part 5 of Omens here!…2 Comments
When I last left you in the tale of Rei Sommerset, the newly-resurrected Warlock discovered not only the growing suspicious of a spy in their…Leave a Comment
Welcome to the New Year, Guardians, and December has been quite an end to an amazing year with Bungie! First, on December 5th, Bungie released…Leave a Comment
With a brief break on account of the Christmas weekend and finishing a new book, Fiction Friday has returned! This is Episode 2 (Parts 3…2 Comments
Welcome to something new for the holidays — Fiction Friday! We're presenting over the next consecutive Fridays this novella from Tee Morris, set in the…4 Comments


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Asian Tribune is published by E-LANKA MEDIA(PVT)Ltd. Vol. 20 No. 102
How you say FEAR NOT,when "the TWO" lead us?
Do you think that our Sinhalese society would accept KadirKamar as the Presidential or PM Candidate if he lived now?
Don't you have a worst fear due to a combination of Mahinda as the president and Anura as the prime minister. Both of them has no vision as to where to take the country and its people. So it will be a government of 'Yanne Koheda? Malle Pol'.
Could Chandrika be made zero, at the rate Rajapakse proceeds with signatures; Will she after her term, be able to tolerate to be at TAP, having been enjoyed at the TOP?
What do you all say?


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Latest Blog Posts
Latest Blog Posts
It's A Wonderful Life: 5 Magic Keys from the Japanese Tea Ceremony...#BetterWithMissJones Matcha Frosted Lavender CupcakesMatcha mania is sweeping the US at the moment. Bon Appetit has recipes for everything from matcha donuts to matcha smoothies and spa day masks! Starbucks has "shaken, not stirred" 007 sexy iced green tea and sensuous matcha lattes. It makes me giggle to see this matcha storm brewing in America. In Japan, matcha mania is also alive and well. (And has been around for as long as I can remember.) Myriads of yummy cakes, ice creams... Read More
Dive into Pleasure, 5 Skinny Secrets from Japan, #Gluten-Free #GlutinoGlutino kindly provided the gluten-free products pictured in this post. All opinions are my own. Dive into Pleasure, 5 Skinny Secrets from Japan, #Gluten-Free #Glutino Ahhhh, the holidays! Bright lights, beautiful presents and big temptations entice this foodie. Growing up in Japan (babyhood to UCLA) allowed me to glean a few secrets to staying skinny. Yes, Virginia there is a Santa Claus. You can enjoy your Christmas cake and eat it too! Even... Read More
Good News from The Ninja BakerHolidays bring families together, gifts around the Christmas tree and sweet carols. Or candle lighting of the Menorah with loved ones. In Japan, Christmas is typically a commercial holiday; so, Christmas cake appears. (Bestsellers tend to have tons of strawberries, whipped cream and cute chocolates.) Keeping with the good cheer of the season, I want to share some sweet news. 1. For you or the foodies in your life, click this link to a... Read More
Chocolate Pumpkin Brownies, #SundaySupper"If you do not waste, you will never have lack." (無駄なければ、不足がなし) The Japanese version of "waste not, want not." Canned pumpkin and chocolate candies are always purchased in abundance during the holidays. (What's the point of a stocking if Santa doesn't deliver chocolates?) Start the violins…luscious chocolates are the typical "leftovers" from the holidays at this Ninja Baker's home.... Read More
A Mother's Love, Miracles and The Breakaway BakeryA Mother's Love, Miracles & The Breakaway Bakery A mother's love for her daughters miraculously saved her own life. Exhausted and without energy, Janice Lavine continued to care for her children. Including trips to the doctor. When one daughter was given a list of allergies and foods to avoid, Janice kept her company. She joined in on the restricted regime. Janice suddenly found the prescribed gluten-free, dairy free... Read More
Japanese Sugar Plum Fairy Cupcakes, #SundaySupperClap your hands if you believe in fairies! Sugar plum fairies from The Nutcracker! Ballet in Japan is a big after-school activity. Many Japanese moms chauffeur or take trains with their ballerina princesses to class. So, The Nutcracker is a familiar figure on stage and in stores at Christmas time in Japan. Need a Nutcracker ballet refresher? In a nutshell (tee hee): Toys around the Christmas tree come alive at midnight. Including... Read More
Miso Glazed Corn, #SundaySupperOnce Upon a Time in the faraway land of ancient Japan, families made their own miso. Soybeans and sea salts were tossed in with rice. Barley and wheat were used to make miso, too. (Rice was pretty pricey for a few centuries.) Japanese koji (fermented cooked rice and soybeans) was key to the storage of miso during snowy winters in the olden days. (Way before refrigeration and supermarkets.) Each home had their unique take and flavor of... Read More
Pumpkin Chocolate Cake, #SundaySupperHalloween is now a booming business in Japan. Like Christmas, the sweets shops concoct cute treats for the holiday. The holiday is strictly commercial. Halloween costume parties (and Christmas parties) are ever popular. Still, it's just a reason to celebrate and have a good time. There is no trick or treating on Halloween. Growing up in Tokyo, my friends and I would trick or treat in "gaijin" (foreign) compounds. The lucky... Read More
Under the Tuscan Sun, Lemony Honey Lavender Glazed Japanese Yuzu CakeUnder the Tuscan Sun, 20th Anniversary Edition, Lemony Honey Lavender Glazed Japanese Yuzu Cake Anniversaries bring reflection and hopefully celebration. Reading Frances Mayes' 20th birthday edition of Under the Tuscan Sun delivered both reflection and celebration to this reader. Long before Under the Tuscan Sun was a blockbuster movie; I picked up the first edition of the book. Journeying with Mayes the first time was wonderful. ... Read More


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But we Mumbaikars are known to be stubborn and do not thoughts much of the issues and still find completely happy moments with our love. Say it the angle of being a Mumbaikar or call it the strength of your love.
A weekend away at a bed and breakfast is a superb alternative if your finances is lower than $500. In the event you keep on with a place that isn't more than $150 an evening and includes breakfast, you still have $200 for lunch and dinner. Hitting up coastal cities with quaint eating places and retailers, or villages in the mountains with stunning views, will present all the romance you will want.
Turks and Caicos Islands Sofia Vergara and Joe Manganiello didn't waste any time jetting off to their honeymoon at Parrot Cay by COMO within the Turks and Caicos Islands. The pair confirmed some skin and snapped selfies on the mile-lengthy, white-sand seaside. No doubt the couple also loved their own non-public pool, direct beach entry and round the clock attention from their personal butler. #Jofia is not the primary A-List pair to steal away to this 1,000-acre personal-island resort; Ben Affleck and Jennifer Garner got hitched right here in happier times.
Plan a honeymoon to Phuket, Thailand's largest island. Dozens of romantic, ultra-luxe resorts and motels cater to completely satisfied couples' each whim, including Six Senses Yao Noi , the Naka Island Resort & Spa or Mother Tri's Villa Royale Sure, there are cheaper options, however why not splurge? It's your honeymoon! And we'd be remiss if we didn't point out that Phuket has a number of the most stunning beaches in Thailand. A visit to Patong Beach , which made our record of the world's sexiest beaches , ought to be added to any to-do list throughout a getaway on this tropical island.
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Identify What's Yours to Shout About
Now more than ever, we're seeing people talking about issues that they're not best placed to speak on. It's important to remember not every issue is yours to change. Partly because we need more diverse and intersectional activism, but also because if want real, meaningful and systemic change it need to come from those who know the issue best. It's also important to remember that campaigning, volunteering or activism is hard bloody work, and if you want to succeed in it you have choose something that comes from your belly – something that is part of you. Something you care about so much that when things get hard, exhausting or you hit blocks, you won't consider giving up on. If you're looking around picking something to change for the act of doing it not the passion, chances are you'll run out of steam pretty quickly.
Use Your Skills, Then Plug Your Gaps
Sit down and write down the things you're really good at. It could be art, speaking, working with kids, delegating, writing, strategy – anything. Knowing what you want to shout about or change is one thing, but knowing what the delivery system is another, and it's just as important. It's so so critical to use the strengths that are unique to you to achieve the change you want. Why? Because a) people respond to authenticity and b) utilising something you're good at already gives you way more chance of succeeding. When I launched the upskirting campaign I knew I was good at digital marketing, media, getting people emotionally engaged and public speaking. Was I knowledgable about legal technicality and political procedure? No. I was completely useless at it. So, I found someone who was and we worked together as a tight team. Knowing your strengths and your shortcomings, being honest about it, and working accordingly is a huge advantage then it comes to using your voice for good.


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Apple Time Capsule Review: Trash or Treasure?
All too often unnecessary gadgets eat up time instead of saving it. How many times have you seen that poor soul in the movie theatre tinkering with his or her phone when a golden moment happens on-screen? It's painful to watch.
The Time Machine is one of those rare devices that attracts little to no attention from the user. It doesn't have one button on it: even the on/off switch was deemed unnecessary by Apple. The design is attractive, yet the appeal is surprisingly limited. It's a device that protects your data by creating "set it and forget it" backups, and doubles as a wireless router or NAS. Apparently that isn't very sexy (thus the lack of reviews).
Although everyone that creates content can benefit from it, too many are looking for cheap thrills for their hard-earned dollar. This little white box is like vegetables: it can do wonders for you but most people prefer the "crash and burn" approach; At least before something goes wrong.
At the time of this writing, two versions are being offered. You can choose from either 1TB or 2TB of storage.
Apple's claims that the Time Capsule includes a server-grade hard drive are exaggerated. Inside there is a Hitachi Deskstar. It's a good, solid drive for desktop computers, but hardly a professional server drive. This would simply be impossible since server drives don't come cheap and would drive manufacturing prices through the roof. Most likely Apple is cherry picking the best Deskstars as they often do with hardware.
Time Capsule works based on the 802.11n wireless spec. To give you an idea of the speed, when data is dropped from a MacBook Pro to the Time Capsule, data is transferred at about 2MB per second in a real-world test. The transfer rate is lightning fast. However, be warned that backups can take a while since you may be backing up several gigabytes at a time. This of course depends on how much new data you create on your computer each day.
There aren't as many LAN ports in the back as many routers but it should be plenty for most home networks, especially those planning to take full advantage of wireless. One Gigabit Ethernet WAN port allows you to connect the Time Machine to your high-speed modem. Three ports are provided for wired connections to the network, and the USB port allows you to connect a device such as a printer to the network.
Also of note: it works equally as good with a Mac or PC. The Airport Utility isn't quite as sleek on the PC side, but functionally it works just as well.
Any Apple fan can benefit from the Time Capsule. For notebook users however, it's a match made in heaven. You no longer need to connect an external drive to your Macbook or Macbook Pro to create backups with Time Machine. As long as you are connected to the wireless network, Time Capsule will start its backup according to the automated schedule.
Some folks wish Time Machine provided more control over the scheduling options. Apple's approach gels perfectly with me and it has gotten me out of several jams. I haven't lost one kilobyte of data since buying the Time Capsule.
Here's how it works:
- Hourly backups for the past 24 hours.
- Daily backups for the past month.
- Weekly backups for all previous months.
- Oldest backups are deleted when the disk is full.
Its system is very well thought out. Both storage capacity concerns and the practicality of backups are balanced. If something does go missing, you'll likely spot it within a few days, and certainly before a month goes by.
Another handy use for the Time Machine is to use it to switch all your data over to a new computer or to get your files back after you reinstall Mac OS X. It will test your patience as well since you probably have loads of data on your computer at any given time. Connect a LAN cable, start the transfer then go out and grab a few cheesy chilli burritos for best results. Whatever you do, don't stare your Time Capsule down during a big transfer. It doesn't like that.
Review Verdict
The Time Capsule gets used several times a day at my home network, even though I hardly realise it. That is the beauty of it: Apple's cute white box works entirely in the background. I have the older 500GB version, and although the size is ample for my needs, you can never have enough hard drive space. Strongly consider the 2TB model if you are in the market for a NAS.
Although it isn't flying off the shelves like the iPad, it's very tough to find fault with such a simple, functional concept that works great in the real world. So what are you waiting for? Get one now.
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Showcase and Display Case Manufacturer
Since 1998
We offer basic cases, economy cases, wall cases, and more. You can find economy cases from 48" to 70", and whether you need panel or mirror casing, we can help you get it.
You can work with us for register stand flats and well top cases or showcase combo sets. Give us a call to get the best cases on the market. You'll be able to purchase directly from the manufacturer, helping you save on every item. For fast delivery and expert service, call us now.
You can get wall cases in many forms, including trophy cases and standard sizes. There are also extra vision wall cases and square tower cases with display towers.
Full vision showcases allow you to display more merchandise. Storage options are not available. Full vision showcases are 38" high and 18" deep. They are available three lengths, and the base is 12" high. Glass display area is 26" high and includes one row of 10" deep glass shelving. Economy cases are available in full vision, outside corner, half vision, jewelry case, sit-down jewelry, corner filler, register stand flat and well top, and wrap corners.
Basic cases:
You can get basic cases in many forms. You can have open merchandise, wrap counter, half vision, jewelry cases, full vision, outside corner, open merchandise corner and filler, wall cases, register stand flat and well top, and register stand showcase combo, as well as trophy showcases and slot walls.
These are our standard colors. Please inquire about laminates.