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TIGER-2: A Phase 2, Open-label, Multicenter, Safety and Efficacy Study of Oral CO-1686 as 2nd Line EGFR-directed TKI in Patients With Mutant EGFR Non-small Cell Lung Cancer (NSCLC)
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT02147990
Recruitment Status : Terminated (Sponsor discontinued development of CO-1686 for NSCLC.)
First Posted : May 28, 2014
Last Update Posted : October 2, 2019
- Study Details
- Tabular View
- Results Submitted
- Disclaimer
- How to Read a Study Record
|Condition or disease
|Non-small Cell Lung Cancer
|Drug: Rociletinib
|Phase 2
This is a Phase 2, single arm, open-label, dual cohort, multicenter study evaluating the safety and efficacy of rociletinib administered orally to patients with previously treated mutant EGFR NSCLC.
Patients will be enrolled into 2 cohorts. Cohort A will enroll approximately 125 eligible patients who are centrally confirmed T790M-positive. Cohort B will be a continuation of the study and will enroll up to approximately 100 eligible patients who will be either centrally confirmed T790M-positive or T790M-negative.
All patients (for Cohort A and B) should have experienced disease progression while on treatment with the first single-agent EGFR-directed TKI (EGFR-TKI) for advanced/metastatic NSCLC. One line of chemotherapy prior to the EGFR-TKI treatment is permissible.
The study (Cohorts A and B) will consist of a screening phase to establish study eligibility and document baseline measurements, an open-label treatment phase, in which the patient will receive rociletinib to ascertain safety and efficacy until disease progression as defined by RECIST Version 1.1, clinical tumor progression, or unacceptable toxicity as assessed by the investigator. For patients with clinical progression, radiographic assessment should be performed to document evidence of radiographic progression.
|Study Type :
|Interventional (Clinical Trial)
|Estimated Enrollment :
|225 participants
|Intervention Model:
|Single Group Assignment
|None (Open Label)
|Primary Purpose:
|Official Title:
|TIGER-2: A Phase 2, Open-label, Multicenter, Safety and Efficacy Study of Oral CO-1686 as 2nd Line EGFR-directed TKI in Patients With Mutant EGFR Non-small Cell Lung Cancer (NSCLC)
|Actual Study Start Date :
|June 16, 2014
|Actual Primary Completion Date :
|July 30, 2019
|Actual Study Completion Date :
|August 27, 2019
|Experimental: Rociletinib Mono-Therapy
Drug: Rociletinib
Rociletinib will be administered to patients orally
Other Name: CO-1686
- Objective Response rate (ORR) according to RECIST Version 1.1 as determined by independent radiology review (IRR). [ Time Frame: Every 8 weeks until disease progression, up to approximately 24 months ]
- Duration of Response (DR), Disease Control Rate (DCR) and Progression Free Survival (PFS) according to RECIST Version 1.1 as determined by IRR [ Time Frame: Every 8 weeks until disease progression, up to approximately 24 months ]
- Objective Response Rate (ORR), Duration of Response (DR), Progression Free Survival (PFS), Disease Control Rate (DCR) as determined by Investigator Assessment [ Time Frame: Every 8 weeks until disease progression, up to approximately 24 months ]
- Overall Survival [ Time Frame: Every 4-8 weeks until date of death, up to approximately 60 months ]
- Change from baseline in patient reported outcomes using EORTC QLQ C30, EORTC Quality of Life Questionnaire Lung Cancer module (EORTC QLQ LC13), and the Dermatology Life Quality Index (DLQI) [ Time Frame: Every 8-12 weeks until disease progression, up to approximately 24 months ]
- Treatment emergent adverse events (AEs), laboratory abnormalities and ECG abnormalities [ Time Frame: Every 4 weeks until treatment discontinuation, up to approximately 24 months ]
- Plasma PK parameters for rociletinib based on sparse sampling [ Time Frame: Every 4 weeks for approximately 6 months ]
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years and older (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria
- Histologically or cytologically confirmed metastatic or unresectable locally advanced NSCLC
- Documented evidence of a tumor with 1 or more EGFR mutations excluding exon 20 insertion
- Disease progression confirmed by radiologic assessment while receiving treatment with the first single agent EGFR-TKI
- EGFR TKI treatment discontinued less than or equal to 30 days prior to planned initiation of rociletinib
- The washout period for an EGFR inhibitor is a minimum of 3 days
- No intervening treatment between cessation of single agent EGFR TKI and planned initiation of rociletinib
- Previous treatment with less than or equal to 1 prior chemotherapy (excluding prior neo-adjuvant or adjuvant chemotherapy or chemoradiotherapy with curative intent)
- Any toxicity related to prior EGFR inhibitor treatment must have resolved to Grade 1 or less
- Central laboratory confirmation of the presence of the T790M mutation in tumor tissue in Cohort A and the presence or absence of the T790M mutation in tumor tissue in Cohort B. Centrally indeterminate, unknown or invalid specimens are not acceptable. Biopsy material obtained from either primary or metastatic tumor tissue and sent to the central laboratory must be within 60 prior to dosing study drug but following disease progression on the first EGFR TKI
- Measurable disease according to RECIST Version 1.1
- Life expectancy of at least 3 months
- ECOG performance status of 0 to 1
- Minimum Age 18 years (in certain territories, the minimum age requirement may be higher eg age 20 years in Japan and Taiwan)
- Adequate hematological and biological function, confirmed by defined laboratory values
- Written consent on an IRB/IEC-approved Informed Consent Form (ICF) prior to any study specific evaluation
Exclusion Criteria
- Documented evidence of an exon 20 insertion activating mutation in the EGFR gene
- Active second malignancy i.e. patient known to have potentially fatal cancer present for which he/she may be (but not necessarily) currently receiving treatment
- Patients with a history of malignancy that has been completely treated, with no evidence of that cancer currently, are permitted to enrol in the trial provided all chemotherapy was completed greater than 6 months prior and/or bone marrow transplant greater than 2 years prior
- Known pre-existing interstitial lung disease
- Cohort A only: Patients with leptomeningeal carcinomatosis are excluded. Other central nervous system (CNS) metastases are only permitted if treated, asymptomatic, and stable (not requiring steroid for at least 4 weeks prior to the start of study treatment). Cohort B only: Patients with CNS metastases or leptomeningeal carcinomatosis are excluded.
- Treatment with prohibited medications less than or equal to 14 days prior to treatment with rociletinib
- Patients who are currently receiving treatment with any medications that have the potential to prolong the QT interval and the treatment cannot be either discontinued or switched to a different medication before starting rociletinib
- Prior treatment with rociletinib, or other drugs that target T790M positive mutant EGFR with sparing of wild type EGFR
- Any of the following cardiac abnormalities or history
- Clinically significant abnormal 12-lead ECG, QT interval corrected using Fridericia's method (QTCF) greater than 450 msec
- Inability to measure QT interval on ECG
- Personal or family history of long QT syndrome
- Implantable pacemaker or implantable cardioverter defibrillator
- Resting bradycardia less than 55 beats/min
- Non-study related surgical procedures less than or equal to 7 days prior to administration of rociletinib. In all cases, the patient must be sufficiently recovered and stable before treatment administration
- Females who are pregnant or breastfeeding
- Refusal to use adequate contraception for fertile patients (females and males) while on treatment and for 12 weeks after the last dose of rociletinib
- Presence of any serious or unstable concomitant systemic disorder incompatible with the clinical study
- Any other reason the investigator considers the patient should not participate in the study
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02147990
|Responsible Party:
|Clovis Oncology, Inc.
|ClinicalTrials.gov Identifier:
|Other Study ID Numbers:
|First Posted:
|May 28, 2014 Key Record Dates
|Last Update Posted:
|October 2, 2019
|Last Verified:
|September 2019
locally advanced
non-small cell lung cancer
epidermal growth factor receptor
EGFR-directed therapy
irreversible EGFR inhibitor
Lung Neoplasms
Carcinoma, Non-Small-Cell Lung
Respiratory Tract Neoplasms
Thoracic Neoplasms
Neoplasms by Site
Lung Diseases
Respiratory Tract Diseases
Carcinoma, Bronchogenic
Bronchial Neoplasms


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Weird goings-on at the Daily Express, where the Cheltenham and Gloucester appears to be sponsoring its coverage of the Bob Woolmer murder investigation.
Last week, Grey Cardigan commented on the accommodating approach of the Express commercial team, which surrounded a single lovely-looking Woolmer story with a C&G ad.
Then this week, the same ad appeared again surrounding an almost identical looking story (see pictures above).
Axegrinder is not one to indulge in idle conspiracy theories, but perhaps the Cheltenham and Gloucester poisoned Woolmer to collect the life assurance after he defaulted on his mortgage and is now keen to deflect attention from Daily Express stories getting too close to the truth by placing these colourful eye-catching ads.

subset: commoncrawl


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Pure Angel Cloud Tie Dye Hoodie
Don't cry sweet bb girl, we know you are the purest angel of them all. These are custom tie-dye hoodies that have the best selling "Pure Angel" design screen printed on the center chest. The eyes are telling you that you need this in your life to complete you.
Keep it cozy angelz.
- Machine wash cold, tumble dry low.
- Unique dye treatment used, color and design may vary.
- Relaxed fit.
- See size guide below
Model is 5'5" wearing size medium.


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Chinese bitcoin exchange BTCChina said on Thursday that it would stop all trading from September 30, setting off a further slide in the value of the cryptocurrency that left it over 30 percent away from the record highs it hit earlier in the month, Reuters reports.
1/ After carefully considering the announcement published by Chinese regulators on 09/04, BTCChina Exchange will stop all trading on 09/30.— BTCC (@YourBTCC) September 14, 2017
China has boomed as a cryptocurrency trading location in recent years, as investors and speculators flocked to domestic exchanges that formerly allowed users to conduct trades for free, boosting demand.
But that has prompted regulators in the country to crack down on the cryptocurrency sector, in a bid to stamp out potential financial risks as consumers pile into a highly risky and speculative market that has seen unprecedented growth this year.
BTCChina said its decision was based on a September 4 directive from Chinese authorities that expressed concern over investment risks involved in cryptocurrencies and ordered a ban on so-called initial coin offerings, or ICOs - the practice of creating and selling digital currencies or tokens to investors to finance start-up projects.
That ban, as well as warnings by regulators in other countries, has driven fears of a wider crackdown and prompted a sell-off that has helped wipe almost $60 billion off the total value of cryptocurrencies since they hit record highs at the start of the month, according to industry website Coinmarketcap.
"The Chinese ban is causing a panic in the market as mixed messages and lack of clarity has turned sentiment negative," said Charles Hayter, founder of data analysis site Cryptocompare.
"The closure of BTCChina is perhaps a portent of what the other Chinese exchanges face."
BTCChina, one of China's largest bitcoin trading platforms, which also runs an international exchange out of Hong Kong, will stop registration of new users from Thursday, it said on its official microblog.
"We will stop all trades on the digital trading platform starting Sept. 30," it said. Its co-founder, Bobby Lee, told Reuters the move would not affect trading on the BTCC international exchange, however.
The price of bitcoin (EXANTE: Bitcoin) tumbled particularly sharply on BTCChina after the news. By 1233 GMT, it was down 18 percent on the exchange, at 20,510 yuan.
On U.S. exchange Bitstamp, it slid as much as 10 percent to a five-week low of $3,426.92, having hit a record high of nearly $5,000 on September 2.


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- Description
Today's current turbulent environment is more demanding than ever before. In this digital age your organization is required to transform and adapt all the time. At the same time, you need to stay in control. Your change capability is the key to the survival and growth of your organization.
In this webinar, Marc Lankhorst and Peter Matthijssen – authors of the book "The Adaptive Enterprise" – will share with you the six capabilities that will help you excel at change. Enterprise Architecture is one of the key disciplines for organizations to develop towards a true adaptive enterprise.
- Additional Information
Additional Information
Reference D178 Author(s) Marc Lankhorst and Peter Matthijssen (BiZZdesign) Published 1 Nov 2016 Duration 1 hour 1 minute Type Webinars Subject Architecture
- Reviews


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Your cold storage equipment may be one of the most important choices you make. A significant amount of costs are associated with your walk-in. Before you purchase, make sure you consider the entire lifecycle of the walk-in instead of just the acquisition price.
The two main elements that effect energy and cost savings while running a walk-in are the refrigeration and insulation. To get the optimal results from your refrigeration it must be sized correctly taking in consideration the size of box, if it is a cooler or freezer, and what will be stored inside. (There are many other factors that are considered when sizing refrigeration.) Insulation is the key to energy savings because it is responsible for holding the cool temperature in the box so the refrigeration does not have to work overtime. Insulation quality is measured by R-value; the resistance to heat flow through an object. Since EISA was implemented January 1, 2009, all walk-in manufactures are required to have an R-value of R-25 for coolers and R-32 for freezers. Now that all manufacturers follow the same requirements, the performance of the insulation is what differentiates the walk-in.
The two common types of insulation used are polyurethane and extruded polystyrene. Each type of insulation brings with it strengths and weaknesses that must be evaluated for each individual application.
|Extruded Polystyrene
|Starts with a high R-value. Smaller cell structure. Resists moisture absorption. Closed cell structure.
|Out gases some. Over time, R-value decreases minimally.
|Starts with a high R-value. Closed cell structure.
|Out gases more. Over time, R-value decreases steadily. Is susceptible to moisture infiltration.
U.S. Cooler uses both insulations. Through experience and research, U.S. Cooler believes extruded polystyrene is the best insulation for the walls, ceiling, and floors of coolers and freezers. Polyurethane is better to insulate the doors of their walk-ins. According to a study performed by the U.S. Corps of Engineers, they found that over a five year period extruded polystyrene retains 75% of its R-value while polyurethane retains 25%.¹ This is one reason why U.S. Cooler believes extruded polystyrene provides the most value and the best option for walk-in insulation.
Retaining a high R-value is important in saving energy costs. The higher the R-value, the less the refrigeration will have to work to hold the required cold temperatures. As a result, the less the refrigeration works the less your energy costs will be.
When considering the actual performance of walk-in coolers and freezers, being informed can pay substantial long-term benefits. You pay for the walk-in once, but if the insulation and refrigeration are inefficient, it will cost you every month for the life of the walk-in. Acquisition price should not be the only consideration when purchasing your walk-in. Initial purchase savings can be quickly eliminated by unnecessary operational costs over the lifetime of the walk-in.
To see how much you could save on an Extruded Polystyrene walk-in, check out our Energy Savings Calculator.
¹ U.S. Army Corps of Engineers (CRREL) test data. "New Wetting Curves for Common Roof Installations," by Wayne Toblasson, Alan Greatorex and Doris Van Pelt; Cold Regions Research and Engineering Laboratory, Hanover, New Hampshire 1991.


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Mathematics Materials
All math units are available for purchase from Prufrock Press. We encourage you to purchase the materials directly from our publisher, and you can do so by clicking on each book's title to visit Prufrock's site.
Thinking Like a Mathematician focuses on high-interest, career-related topics in the elementary curriculum related to mathematics. Students will explore interdisciplinary content, foster creativity, and develop higher order thinking skills with activities aligned to relevant content area standards. Students will engage in exploration activities, complete mathematical challenges, and then apply what they have learned by making real-world connections.
Splash! is a mathematics unit for high-ability learners in grades K–1 focusing on concepts related to linear measurement, the creativity elements of fluency and flexibility, and the overarching, interdisciplinary concept of models. The unit consists of 13 lessons centered on the idea of designing a community pool. Students examine the question of why we measure, the importance of accuracy in measurement, and the various units and tools of measurement.
Spatial Reasoning
Spark the visual learning of students in grades 2–4 with Spatial Reasoning, a mathematics unit for high-ability learners. Gifted students demonstrate an advanced aptitude for spatial reasoning at early ages, and they require more complex lessons than what the standard curriculum provides. This field-tested unit approaches spatial reasoning through one-dimensional, two-dimensional, and three-dimensional tasks that will engage students.
Polygons Galore!
Polygons Galore! is a mathematics unit for high-ability learners in grades 3–5 focusing on 2-D and 3-D components of geometry by exploring polygons and polyhedra and their properties. The van Hiele levels of geometric understanding provide conceptual underpinnings for unit activities. The unit consists of nine lessons that include student discovery of properties of polygons and polyhedra, investigations for finding areas of triangles and quadrilaterals, study of the Platonic solids, and real-world applications of polygons and polyhedra.
Beyond Base Ten
Looking for a way to challenge your gifted students grades 3–6? Look no further! Beyond Base Ten investigates the concept of place value and the representation of numbers by using place value and non-place-value systems. Number bases other than Base Ten are featured, especially through historical contexts of early civilizations that developed number systems different from the one we use today.
Moving Through Dimensions
Moving Through Dimensions approaches spatial reasoning through one-dimensional, two-dimensional, and three-dimensional tasks designed for students in grades 6–8. The unit also asks students to explore the transition between dimensions and representations of three-dimensional objects in two dimensions. This book includes pre- and post-assessments, multiple reproducible materials, and lessons based on NCTM standards.


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Via Sacra
Legend says that King Numa erected the Regia, or king's house, where he spent the greater part of his time, performing divine sevice, instructing the priests, or conversing with them on sacred subjects. It became the official headquarters of the Pontifex Maximus and the place of assembly of the sacred colleges. Here were kept the archives of the pontiffs, the formulas of all kinds of prayers, vows, sacrifices, etc., the state calendar of sacred days, the Annales- the record of events of each year for public reference- and the laws relating to marriage, death, wills, etc. Here, too, were the ancilia, the shields of Mars, which had fallen from Heaven and were carried by the Salii, the dancing priests of Mars.
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There are two distinct messages that were preached. There are two distinct periods off time these messages occurred. The Gospel of the Kingdom is not to be mixed up with the Gospel of the death and resurrection of Christ. The Gospel of the Kingdom was preached under the Law of Moses...during the earthly ministry of Christ. The Gospel pf the death, burial, and resurrection of Christ was preached under Grace...after Christ died ascended to Heaven where He rules from today.
Not knowing how to rightly divide the Word of God is so prevalent in our present age. Some people have misinterpreted 2 Chronicles 7:14 by spiritualizing the content and applying the passage to the Church today. This is dangerous, as the passage is a clear reference to the nation of Israel and promises the restoration of their land. This passage has no reference to the United States.
2 Chron 7:14...If my people, which are called by my name, shall humble themselves, and pray, and seek my face, and turn from their wicked ways; then will I hear from heaven, and will forgive their sin, and will heal their land.
First of all it says, "If my people which are called by my name shall humble themselves". God's people in the Old Testament was the nation of Israel/the Hebrew nation. Israel was to humble themselves to keep the Law. Christian's don't humble themselves to keep the Law. Christian's are humble by the power of God's Spirit that changes the moral makeup of a child of God. Israel was to seek the face of God...Christians don't seek the face of God...Christian's are found by the face of God. Israel constantly sought God by keeping the Law and offering sacrifice. Christian's find God and the Christian experience when forgiveness of sin and holiness of heart takes over their lives through the effect of Calvary in the human soul. This experience is found through a Christian's faith in the person of Christ. Christian's don't constantly seek God, they are satisfied with what they found in the person of Christ...Salvation, peace, and contentment. Israel was to turn from their wicked ways. Christian's turn from evil the minute they believe in Christ ... and live the holy life after they believe in Christ. Christian get rid of wickedness when they accept Christ as Saviour. Israel was a backslidden and disobedient people. Christians are true and obedient to God. Isreal had to be forgiven from a backslidden state. Christian's are washed, cleansed, and forgiven by through the precious blood of Jesus Christ. This healing of Israel's land implied restoration that will be given to Israel when the Kingdom of Heaven is established on Earth. God will restore the land, the crops with rain, the plant life, the animal life, etc.
All that said to say this, "Spiritualization of Scriptures that are given to Israel and misapplying these to the Church now is "wrongly dividing God's Word". It's dangerous, deceptive, misleading, and rampant this present hour.
If Israel would have accepted the Messiahship of Jesus this would have brought full restoration of the land. The only thing Israel had to do was to receive the message of the Kingdom by Jesus Christ the Messiah, John the Baptist, and the disciples. In their combined years of preaching, their message certainly was not the message of the death, burial, and resurrection according to the Prophets , which is the true Gospel.
Jesus did not preach His death, burial, and resurrection. In fact, He said very little about it until after He had given the Kingdom message to Israel and they had rejected the Kingdom of Heaven. They rejected His reign on earth saying,
Luke 19:14...We will not have this man to reign over us.
Only after they rejected their long-awaited Messiah did Jesus begin to talk about His crucifixion. He began to foretell how He would be delivered into the hands of the Gentiles, how they would crucify Him, and how He would rise again the third day*.
*When the books of Matthew, Mark, Luke, and John are examined closely anyone who studies will be able to see where the Kingdom message ended and Christ began speaking about His crucifixion. For example,
Matt 16:20-21...Then charged he his disciples that they should tell no man that he was Jesus the Christ. From that time forth began Jesus to shew unto his disciples, how that he must go unto Jerusalem, and suffer many things of the elders and chief priests and scribes, and be killed, and be raised again the third day.
When Christ, Himself, told Peter that He was actually going to die, Peter did not believe Him.
Matt 16:22...Then Peter took him, and began to rebuke him, saying, Be it far from thee, Lord: this shall not be unto thee
Peter did not have Christian faith or New Covenant faith. He did not have faith in the death of Christ. He could not accept that Christ was going to die. Because of Peter's disbelief, he could not have faith in Christ's death or resurrection.
*Please note that Peter did have Kingdom faith and recognized the Messiahship of Christ in the Kingdom of Heaven as described in this question by Christ,
Matt 16:15-17...But whom say ye that I am? And Simon Peter answered and said, Thou art the Christ, the Son of the living God. And Jesus answered and said unto him, Blessed art thou, Simon Barjona: for flesh and blood hath not revealed it unto thee, but my Father which is in heaven.
The Kingdom message was given to the Hebrew nation with the purpose of offering both Kingdoms to Israel-God's rule over man and man's rule over earth. The Kingdom of God was to rule the hearts of all in Israel to prepare them for dominion over earth. However, instead of accepting His Messiahship, they rejected the Kingdom of Heaven on earth. Christ's reign on earth was rejected by the Hebrew nation.
In order to reign with Christ on earth, man must have a holy heart. This was Christ's message to Nicodemus in John 3
John 3:5...Except a man be born of the water, and the Spirit. The Spirit dealt with promises of the Holy Spirit poured out on Israel and pointed to a future restoration on the earth; a rest, greater than the land of Canaan. Perhaps Nicodemus was familiar with this part of deliverance by the Spirit* however, Jesus questioned him about it.
John 3:10...Jesus answered and said unto him, Art thou a master of Israel, and knowest not these things?
*Deliverance by the Spirit is twofold: 1. It's deliverance from sin in the new birth through the inner work of the Spirit. 2. The outer work of the Spirit when the earth is purged and restored physically where in the future Christ rules on the Throne of David visibly in the Millennial Kingdom.
**Remember, God had provided deliverance to Israel and promised to restore a Kingdom. He also promised to pour out His Holy Spirit! The invisible work of the Holy Spirit through a new birth offered any believing Jew entrance into Christ's visible Kingdom on earth at that time€had the Kingdom message been accepted. Unfortunately, the majority rejected His Messiahship and God's visible Kingdom on earth was postponed.
Here's the message that Peter received when Jesus said,
Matt 16:19...And I will give unto thee the keys of the kingdom of heaven:
To have the Kingdom of God and to be eligible to sit down with Abraham, Isaac, and Jacob, man must be born from above. That Kingdom where Abraham, Isaac, and Jacob will sit down with the saints is, the Kingdom of Heaven.
Here's the difference between the Kingdom of God and the Kingdom of Heaven
Kingdom of God...The operation of God that gives man a holy heart. God saves man from his sins; sanctifies him by the Spirit; and gives him a divine nature to live a holy life. A believer receives the Kingdom of God within. This inner work is an invisible and spiritual Kingdom where God reigns over man from His Throne in Heaven.
Kingdom of Heaven...The operation of God that gives man the earth to rule and reign. This operation takes place when Christ comes back the second time. In order for any man to receive the Kingdom of Heaven he must first have the Kingdom of God in his heart. The Kingdom of Heaven is an earthly and physical Kingdom where Christ physically rules from His earthly Throne in Jerusalem


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Solgar L-Tyrosine 500mg Vegetable Capsules
L-Tyrosine is an important amino acid when it comes to producing the neurotransmitters responsible for controlling your moods, such as the 'feel good' chemical dopamine and epinephrine, a hormone that can help to regulate your response to stress.
Unlike some amino acids, L-Tyrosine can be found it a wide range of foods, however if you are suffering from stress, you may become deficient in L-Tyrosine, enhancing your symptoms. This is why we sometimes recommend L-Tyrosine to our customers here at Jan de Vries and when we do, Solgar is a name that regularly crops up.
Solgar's L-Tyrosine Vegetable Capsules offer a potent source of the amino acid, containing 500mg of free-form L-Tyrosine. This level should help to increase your intake gently, providing a one-a-day supplement that's easy and simple to take.
|Each vegetable capsule provides:
|L-Tyrosine (free-form)
|500 mg
|Vegetable Capsule Shell: hydroxypropylmethyl cellulose
|Bulking Agents: microcrystalline cellulose, hydroxypropyl cellulose
|Anti-caking Agents: vegetable stearic acid, vegetable magnesium stearate
UK Standard delivery is £2.99. For UK orders £19.95 or over this is FREE.
All international orders are sent out through Fedex on a tracked service. Postage zones out with the UK are split into the following 4 zones:
Zone 1 Delivery is £15. (Andorra, Austria, Belgium, Denmark, Faroe Islands, Finland, France, Germany, Greece, Greenland, Ireland, Italy, Luxembourg, Monaco, Netherlands, Portugal, Spain & Sweden)
Zone 2 Delivery is £20. (Canada, Gibraltar, Iceland, Norway, Switzerland & USA)
Zone 3 Delivery is £25. (Albania, Bulgaria, China, Croatia, Cyprus, Czech Republic, Estonia, Hong Kong, Hungary, Japan, Latvia, Lithuania, Macedonia, Malta, Malaysia, Poland, Romania, Serbia, Singapore, Slovakia, Slovenia, Turkey & Ukraine)
Zone 4 Delivery is £30. (Antigua & Barbuda, Azerbaijan, Bahamas, Barbados, Bermuda & Seychelles)


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Girls volleyball: DeKalb sweeps Sycamore
SYCAMORE – The DeKalb volleyball team spoiled Sycamore's senior night, sweeping the match in straight sets, 25-17, 25-14, on Tuesday.
The Barbs (10-22, 2-6 Northern Illinois Big 12) came out firing in both sets. They took advantage of their size, dominating the front of the net. Bella Finch led the team with 3˝ blocks. She also contributed 20 assists and two aces.
"It meant a lot because they took one off of us on our home floor," Finch said. "We came in with a lot more confidence. We have a good shot at regionals."
DeKalb is seeded fifth in its regional. Coach Jamie DiMaggio-Hoscheit believes that her team is peaking at the right time.
"We're a young team, and it took awhile for us to get the ball rolling," DiMaggio-Hoscheit said. "What's cool is that this team has never stopped. We knew that in the beginning it was going to take awhile, but we haven't stopped working hard. We haven't stopped pushing them in the gym. We're excited to keep going and finish the season as strong as possible."
DeKalb's young talent showed flashes again Tuesday. Freshman Julia O'Brien led the team in kills with eight. Sophomore Kallie Siebrasse was right behind her with seven kills. DiMaggio-Hoscheit said that their futures are bright, and they should be a one-two punch for the next few seasons.
"[Siebrasse] and [O'Brien] are going to be deadly in our future," DiMaggio-Hoscheit said. "Our offense looked better because we were putting the ball up and in a playable situation so that our setter could keep our players in a good position to score."
O'Brien said that she has grown both physically and mentally over the course of the season.
"We've just been practicing a lot and working on our skills more in-depth than we have been," O'Brien said. "I think I've gotten stronger mentally."
For Sycamore (16-19, 3-6 Northern Illinois Big 12), the game was a setback for a team that has a lot of talented pieces.
Coach Jennifer Charles said that the focus has to get better.
It's not so much the physical game that we need to clean up," she said. "It's the mental game that we need to clean up right now. We just need to do a better job of executing things that we do on a daily basis. We can't let outside things play into why we're not focused or successful on the floor."
Sycamore senior Faith Reynolds agreed with her coach when it came to the team's lack of focus.
"I definitely think that senior night had an impact when it shouldn't have," Reynolds said. "At the end of the day, we just weren't in the right mindset."
By the numbers: DeKalb may have convincingly won both sets, but it could stand to improve upon its serving. The Barbs only had 83.7 percent of their serves end up in play.
They said it: "A regional championship would make this much better," Sycamore senior Amanda Swedberg said. "This game obviously meant something to us because it is conference, but a regional title would mean a lot more."
Up next: Sycamore will not play again until regionals. DeKalb will travel to Morris for a 6 p.m. game Thursday.