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State Bank of Pakistan organizes International Conference on "Affordable Housing and Mortgage Finance"
Karachi, May 28, 2015 (PPI-OT): A two-day International Conference on Affordable Housing and Mortgage Finance organized by State Bank of Pakistan (SBP) was inaugurated today in Islamabad. The Conference aims to discuss innovative strategies and solutions to increase outreach of housing finance to low and middle income groups.
At the beginning of the conference a message from the Prime Minister, Mian Muhammad Nawaz Sharif, was read by the Deputy Governor, Saeed Ahmed. The Prime Minister said, 'Pakistan is currently confronting a massive challenge of housing backlog of around 9 million units, out of which, a large part pertains to the economically disadvantage families and members of the lower middle class. This, coupled with a weak governance regime of urban civic institutions, has resulted in the mushroom growth of katchi abadies and slums / squatter settlements in major metropolitan areas.
In line with the manifesto of PML (N), our Government is fully committed to resolve the issue of housing shortage in the country particularly for the low income groups. It has announced a comprehensive housing finance scheme which includes construction of 1000 clusters of 500 houses each for low income families all over the country. To ensure cost-effective access to credit for housing, government has undertaken to pick up a portion of the cost of financing on behalf of the borrower over and above 8 percent under this program.
While addressing the audience, Mr. Akram Khan Durrani, Federal Minister for Housing and Works who chaired the inaugural session, appreciated the steps taken by SBP to promote housing finance. He stated that the provision of affordable housing and mortgage finance are paramount to cope with rapid urbanization.
He highlighted the various efforts by the government to come up with affordable solutions particularly for people belonging to low income strata and kachi abadis. He stated that SBP is actively involved in supporting the sector. He emphasized that if proper planning is not undertaken for urbanization it may lead to serious problems.
Governor State Bank of Pakistan, Mr. Ashraf Mahmood Wathra, in his policy address shared SBP's policy framework for enhancing the flow of financial services to middle and low income groups. Mr. Wathra, while asserting the importance of housing and housing finance for the economy, said that the country is witnessing rapid urbanization and escalation in property prices with increasing shortage of housing units especially for low and middle income groups. In the absence of a sound and vibrant housing finance system, we can expect the situation to further deteriorate.
He appreciated DFID, World Bank, AFG and CSAPs for their support in SBP/Mof efforts to improve upon financial inclusion in the country. He further added that housing finance is one of the critical elements to make housing affordable for the new entrants and existing incumbents of major metropolitan cities. The lack of effective institutional framework, secondary mortgage market, high transaction costs, unorganized real estate sector, inadequate property development framework and long term funding arrangements are some of the major constraints in the growth of housing and housing finance in the country.
Earlier, Mr. Saeed Ahmad, Deputy Governor, State Bank of Pakistan in his welcome address highlighted the importance of housing and housing finance for the long term sustainable economic growth. He stated that in Pakistan house financing is less than ½ percent of GDP which is one of the lowest in the world. 'We have currently 9 million unit shortfall.
Each year there is need for 600,000 units but only 300,000 units are constructed. This adds 300,000 number of units to shortfall, he said. In order to increase housing finance to 10 percent of GDP over next 10 years we have to finance some 300,000 units per year. He stressed on the need of bringing innovation in the existing system and increasing the outreach of the housing finance to low and middle income groups.
The conference was attended by over 300 participants including CEOs/Presidents/Executives of banks, MFBs, Multilaterals, Representatives of Builders and Developers and Business Associations, and Academia. Expert speakers on housing finance from around the world and home are participating in the event.
For more information, contact:
Syed Wasimuddin
Chief Spokesman
State Bank of Pakistan (SBP)
Tel: +92-21-39212562
Fax: +92-21-39212563
Email: email@example.com


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Over 1000 Students Registered for Leaving Cert Maths Revision Course
Griffith College hosts the annual free review courses at its campuses in Dublin, Cork and Limerick.
Lexie's Story: Griffith College Stand Behind Make A Wish Foundation
The Make A Wish Foundation is set to launch their newest campaign that focuses around Lexie
Announcing a New Partnership with Templeogue Basketball Club
National institution Griffith College is teaming up with Templeogue Basketball Club.
Griffith College Receive Award for Best Online Learning Experience at Education Awards 2019
The award was presented for the BA (Hons) in Business Studies (Blended) programme.
Schools from across Ireland participate in Griffith College Business Enterprise Competition
Schools from across Ireland participated in the annual Business Enterprise Competition
Griffith College Presents Two Cork DEIS Schools with Educational Bursary
The fifth presentation in the STEAM Bursary rewarded the students of St. Vincent's and St. Colman's.
Griffith's Michael McNamara Awarded at Mayoral Reception in Limerick
Former radio DJ and current Griffith College advisor recognised for services to Limerick society.
Griffith College and IAPI Launch Creative Bursary for DEIS Schools
A new initiative in partnership with the Institute of Advertising Practitioners Ireland.
Donore Credit Union Opens Competition to Griffith Community
Donore Credit Union invites students & alumni to participate in their new marketing competition.
Six Nations Edition: Griffith College and Irish Rugby
Ireland face France Sunday 10 March at the Aviva Stadium in Dublin for round four of the Six Nations
Celebrating World Book Day with Griffith College Student and Author, Sara Donohue
"Studying and writing complement each other. A good balance of structure, learning and creativity"
Six Nations Edition: Griffith College and the Irish Rugby Team
Griffith College has had the pleasure of educating some of the countries finest athletes

subset: commoncrawl


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Saying "Yes" Goes a Long Way
This wasn't exactly the low-key outing Samarah had in mind when she picked-up Casey, but for Samarah, being a Royal Family KIDS Mentoring Club mentor means being God's "yes" girl. So when camper Casey got into the car and insisted on going to Sky Zone—a trampoline park that's usually packed with sweaty, stinky, and highly competitive kids, Samarah said "yes." When they got to Sky Zone and found out they were having a glow-in-the-dark event which costs three times more than normal and lasts three times longer, Samarah said "yes" to that as well.
"Hey, we got matching glow-in-the-dark shirts and socks, so maybe it was worth it," Samarah reasoned. Besides, she knew this day wasn't about her, it was about giving Casey the space to have fun and be a kid. "I was all about saying yes to that," she says. As soon as they started jumping on the trampolines and Samarah saw the smile on Casey's face, she couldn't stop from saying "yes" over and over again. Samarah said "yes" to dodgeball, putting stinky boys in their place on the balance beam, slam-dunk competitions, and jumping until they got kicked out. There was even an opportunity to say "yes" to speaking truth and life into Casey and another teen they met while waiting in line. When they got back in the car, Samarah decided to take it to the next level and make this a day they would never forget. Car windows came down and music was blasting, as Casey and Samarah sang and danced in their seats with all the energy they had left from the day.
"I saw Casey be Casey with no restraints," Samarah remembers. "Every sacrifice I had made that day was worth it." And when Casey asked her to take the long way home, Samarah did not hesitate.
"I was made to love and empower Casey, to make her laugh and help her see her potential," Samarah says. "Being God's 'yes' girl was a gift from God."
*Name changed to protect the child's identity


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Say yes please say its the last week we debate the democratic Health Care bill. I cant take it anymore!! Can you? The President is actually going to go t Ohio and tell us about a cleaning women who has cancer and had to give up Health insurance. Wow..thats bad and I guess I could fin 1 million more who have it worse we are past the point of caring about the stories we want an end game. Right now, the house does not have the vote which means the president does not have the votes.
Senator Graham made the most sense this weekend saying he wont be reaching across party lines at all of the president uses reconciliation to pass this bill... Your serve sir


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backpack wearing pigeons last week in London and did some pollution monitoring of their own. The main bot was equipped with air quality and carbon dioxide sensors, and had GPS and WiFi on board to track and send the information it picked up. The other bot had a "solvent vapours" sensor, but was mainly there to hang out since it didn't have WiFi. There's a video of the romp in the park, but the creators are still mulling over feral bot's air quality findings.
[Via networked_performance]


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Police have arrested MDC Alliance national executive member Joel Gabhuza who is also Member of Parliament for Binga South.
The legislator was charged with undermining the authority of President Emmerson Mnangagwa after allegedly calling him a dog incapable of leading the country.
The remarks were reportedly made at a funeral in Manzyasiya village in Chief Pashu's area on October 23 attended by Gabhuza as provincial chair for the MDC.
He assumed the position after the split with MDC-T party led by Thokozani Khupe.
Gabhuza allegedly criticised Binga people for voting for Zanu PF and President Mnangagwa.
He said the Zanu PF leader had no solution for the shortages of fuel and medicines which are forcing locals to cross the border into Zambia for supplies.
Court heard that an 89-year-old villager from Binga offended by the utterances reportedly walked for about 100km to Binga Police Station to report six days later.
The MP was not formally charged Monday when he appeared before Hwange magistrate Livard Philimon.
He was remanded out of custody to December 13 on $200 bail.
The incident occurred on October 23, said prosecutor Jamesina Makanza.
"On October 23 at 11am the accused was at the burial of John Bwansula Mumpande where the informant and other members of the community were in Manzyasiya village.
"While at the grave site, the accused was invited to speak in his speech he undermined the authority of the President."
Gabhuza - speaking in Tonga said; "You people are disabled; you have chosen a dog who cannot manage to rule the country.
"There is no fuel, medication and I had to go to Zambia to buy fuel which we have used at this funeral. I have said so and if there is anyone who is angered about this I don't care."
This did not go down well with 89-year-old Tholani Driver Ndlovu who, on October 29, reportedly walked 100km to make a report to the police, accusing Gabhuza of insulting Mnangagwa.


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Nucleoporins and the promyelocytic leukemia protein (PML) represent structural entities of nuclear pore complexes and PML nuclear bodies, respectively. In addition, these proteins might function in a common biological mechanism, because at least two different nucleoporins, Nup98 and Nup214, as well as PML, can become aberrantly expressed as oncogenic fusion proteins in acute myeloid leukemia (AML) cells. Here we show that PML and nucleoporins become directed to common cytoplasmic compartments during the mitosis-to-G1 transition of the cell cycle. These protein assemblies, which we have termed CyPNs (cytoplasmic assemblies of PML and nucleoporins), move on the microtubular network and become stably connected to the nuclear membrane once contact with the nucleus has been made. The ability of PML to target CyPNs depends on its nuclear localization signal, and loss of PML causes an increase in cytoplasmic-bound versus nuclear-membrane-bound nucleoporins. CyPNs are also targeted by the acute promyelocytic leukemia (APL) fusion protein PML-RARα and can be readily detected within the APL cell line NB4. These results provide insight into a dynamic pool of cytoplasmic nucleoporins that form a complex with the tumor suppressor protein PML during the G1 phase of the cell cycle.
The promyelocytic leukemia protein (PML) has been implicated in multiple cellular functions including, apoptosis, differentiation, DNA repair, senescence, angiogenesis and virus defense (Bernardi and Pandolfi, 2007; Borden, 2008; Everett and Chelbi-Alix, 2007; Salomoni et al., 2008). In addition, this protein is linked to the pathogenesis of a subtype of acute myelogenous leukemia (AML) termed acute promyelocytic leukemia (APL), because PML is almost invariably expressed as an oncogenic fusion protein (PML-RARα) in APL blasts as a result of the t(15;17) translocation (de The et al., 1990; Kakizuka et al., 1991).
PML is the defining unit of the subnuclear compartments termed PML nuclear bodies (PML-NBs). The ability of PML to assemble into these structures is, in part, stimulated by intermolecular interactions between SUMOylated residues and a SUMO-interaction domain present on the PML protein (Shen et al., 2006). PML also recruits a multitude of other proteins (with diverse functions) to PML-NBs, many of which contain SUMOylated residues or a SUMO-interacting motif (Lin et al., 2006). In APL blasts, the PML-NBs become disrupted as a result of expression of the PML-RARα fusion protein (Dyck et al., 1994; Koken et al., 1994; Weis et al., 1994).
In addition to the PML-NBs that are present within interphase nuclei, PML can also be detected in subcellular mitotic structures, termed MAPPs (mitotic accumulations of PML proteins) (Dellaire et al., 2006; Everett et al., 1999) and in cytoplasmic subdomains that appear during the G1 phase (Dellaire et al., 2006; Everett et al., 1999) or in response to virus infection (Borden et al., 1998; McNally et al., 2008; Turelli et al., 2001). Whereas the nuclear PML-containing bodies have been intensely studied over the past 15 years, comparatively little information is available regarding the biochemical composition or function of MAPPs and the cytoplasmic PML-containing particles.
Nuclear pore complexes, the protein assemblies that form channels through the nuclear envelope, might also contribute to the pathogenesis of certain types of AML. This is suggested by the identification of recurrent chromosomal translocations in AML blasts that involve the genes encoding the nucleoporins Nup98 or Nup214/CAN (Borrow et al., 1996a; Dash and Gilliland, 2001; Graux et al., 2004; Kraemer et al., 1994; Nakamura et al., 1996). In addition, the transcriptional co-activator CREB-binding protein (CBP), which also represents a recurrent target for chromosomal translocation in AML blasts (Borrow et al., 1996b; Dash and Gilliland, 2001), has been shown to functionally interact with nucleoporin-specific FG-repeat sequences (Kasper et al., 1999). Nuclear pore complexes have long been known to have a major role in bidirectional transport across the nuclear membrane (Tran and Wente, 2006; Weis, 2003), but have in recent years also been linked to other cellular functions, such as gene expression regulation (Brown et al., 2008; Faria et al., 2006; Kurshakova et al., 2007; Mendjan et al., 2006). The precise function of nucleoporins in AML pathogenesis, however, has not yet been determined.
In addition to their presence in the nuclear pore complexes of the nuclear membrane, nucleoporins can also be detected in the cytoplasm. In infected cells, as well as in oocytes and embryos of various organisms, fully assembled nuclear pore complexes can be detected at the electron microscopic level as membranous cisternae termed annulate lamellae (Kessel, 1992). In addition, a large excess of soluble, membrane-free nucleoporins in the cytoplasm has also been reported (Onischenko et al., 2004). Although the existence of nucleoporins and nuclear pore complexes in the cytoplasm has been known for several decades, their functions remain largely unknown.
In the present study, we identified a cytoplasmic compartment that contains high concentrations of nucleoporins, as well as the tumor-suppressor proteins PML and CBP. These structures, which we refer to as CyPNs (cytoplasmic accumulations of PML and nucleoporins), form immediately following exit from mitosis, move on microtubule filaments and have the ability to dock at the nuclear membrane. We also find that the cytoplasmic distribution of nucleoporins becomes affected by siRNA-mediated depletion of PML and by expression of the PML-RARα fusion protein, suggesting a functional interaction between PML and nucleoporins that might contribute to APL pathogenesis.
Targeting of PML and nucleoporins to CyPNs
By performing immunofluorescence labeling of HaCaT cells using antibodies against PML in combination with nucleoporin-specific antibodies, we found that PML and components of the nuclear pore complex localize to common cytoplasmic compartments that we have termed CyPNs. Among the nucleoporins that we detected in CyPNs were Nup153, Nup98 and Nup214. In addition, these cytoplasmic compartments were effectively labeled by Mab414, a monoclonal antibody that is known to react with several nucleoporins through the nucleoporin-specific FG-repeat motif (Davis and Blobel, 1986). CyPNs were detected in 8-10% of the cells in an asynchronously growing population of HaCaT cells, and the number of CyPNs that could be detected within a single cell generally ranged from 1 to 20. Notably, colocalization between PML and nucleoporins was detected exclusively in the cytoplasm and not in the nuclear membrane or within the PML-NBs. We also noted that CyPNs frequently contacted the nuclear membrane, indicating an affinity of these structures for the nucleus (Fig. 1A). The formation of CyPNs was not specific for HaCaT cells, because these structures could also be detected in HeLa, MCF7, U2OS and primary fibroblasts in approximately 4%, 5%, 3% and 2% of the cells, respectively. Additionally, in several cells that we examined, the cytoplasmic accumulations of PML were found to be restricted to a subset of nucleoporin-positive structures, suggesting differences in the biochemical composition between different cytoplasmic domains enriched in nucleoporins (Fig. 1B). We were not able to convincingly detect cytoplasmic annulate lamellae in cells that contained CyPNs (e.g. HaCaT cells) by electron microscopy and could therefore not determine whether these two types of structure are related.
CyPNs form during the mitosis-to-G1 transition of the cell cycle
Previous studies have reported a cell-cycle dependent appearance of cytoplasmic PML particles during the G1 phase (Dellaire et al., 2006; Everett et al., 1999). This is consistent with the results described above, which show that only a fraction of asynchronously growing cells contain CyPNs. To verify that CyPN formation is cell-cycle dependent, we analyzed HaCaT cells that had been arrested by culturing in serum-free medium for 3 days and subsequently released into the cell cycle by serum stimulation. Analysis by laser-scanning cytometry revealed that these cells synchronously entered S-phase at approximately 13 hours after serum stimulation, and, following progression through G2 and mitosis, reached a second G1 phase approximately 30 hours after cell-cycle release (Fig. 2A). To determine the level of CyPNs at different cell-cycle stages we scored cytoplasmic foci that stained positive for PML and the nucleoporin Nup153 at different time points after cell-cycle release. By estimating the percentage of CyPN-containing cells, as well as the average number of CyPNs per cell, we found that the level of CyPNs was consistently low during the first 24 hours after cell-cycle release. At 24-30 hours, however, concomitant with exit from mitosis and entry into G1, we observed a considerable increase in the number of these cytoplasmic compartments (Fig. 2A).
A similar result was obtained by analyzing HaCaT cells that had been synchronized by nocodazole-induced mitotic arrest and subsequent release from the cell-cycle block by drug removal. In this case too, we observed an increase of CyPNs as the cells traversed from mitosis to G1 (Fig. 2B). Together, these results show that CyPNs primarily form in G1 cells, and that their assembly is stimulated by a preceding mitosis.
That formation of CyPNs primarily occurs during the mitosis-to-G1 transition was also supported by high-resolution confocal microscopy of HaCaT cells fluorescently labeled with anti-PML and the nucleoporin-specific antibody Mab414. During all stages of mitosis, PML was mainly found to accumulate within MAPPs, whereas the nucleoporins exhibited a dispersed distribution in prophase, metaphase and telophase, and tethered to condensed chromatin during cytokinesis. Immediately after mitosis, concomitant with the formation of two relatively small closely paired daughter nuclei with decondensed chromatin, colocalization between nucleoporins and PML within CyPNs was almost invariably detected (Fig. 2C). These results show that complex formation between nucleoporins and PML is prevented during mitosis but occurs immediately after its completion.
CyPNs move on the microtubular network
We next studied the dynamics of CyPNs using live-cell imaging. For this purpose we monitored the movements of YFP-tagged PML-III transiently expressed in U2OS cells. As shown in Fig. 3A, YFP-PML-III colocalizes with nucleoporins in the cytoplasm and exhibits a cytoplasmic distribution that is consistent with that of endogenous CyPNs. By using a spinning disc confocal microscope, we collected a Z-stack of images every second for a total imaging time of 2 minutes. This experiment revealed that some YFP-PML-III-containing particles move rapidly from one cytoplasmic location to another in short bursts, whereas others remained stationary during the recording period (supplementary material Movie 1). By increasing the intervals between Z-stack acquisitions to 30 seconds and by using a total recording period of 40 minutes, we found that the majority of YFP-labeled CyPNs were capable of moving extensively within the cytoplasm (supplementary material Movie 2). In these longer movies, we also observed several examples of fusions between YFP-labeled cytoplasmic bodies (supplementary material Movie 2). Interestingly, most CyPNs appeared to be highly motile as long as they did not come into contact with the nuclear surface, but as soon as contact with the nuclear envelope had been made, they remained stably connected (Fig. 3B; supplementary material Movie 3). This demonstrates an affinity of CyPNs for the nucleus and might explain why these structures are frequently detected at or within the nuclear envelope (see Fig. 1A).
Owing to the general involvement of the microtubular network in active cytoplasmic transport in mammalian cells, we wanted to determine whether the observed motility of CyPNs is facilitated by microtubule filaments. For this purpose, we pretreated transfected U2OS cells with the microtubule-disrupting drug nocodazole for 2 hours and subsequently recorded the movements of YFP-PML-III by collecting Z-stacks at intervals of 30 seconds for a total imaging period of 40 minutes. The drug treatment caused a considerable reduction in YFP-PML-III motility (compare supplementary material Movies 2 and 4). A similar result was also obtained by treating transfected cells with the microtubule-stabilizing drug vinblastine (data not shown). To obtain a graphic representation of the data presented in supplementary material Movie 2 (untreated cells) and Movie 4 (nocodazole-treated cells), we determined the shortest distance from each of the individual YFP-PML-III-containing particles to the nuclear membrane at each of the time points collected during imaging. These data are presented in Fig. 3C and illustrate reduced motility of CyPNs in nocodazole-treated cells compared with that in untreated cells.
To confirm the association between cytoplasmic PML and microtubule filaments, we coexpressed CFP-PML-III and YFP-α-tubulin in U2OS cells. By using a capture rate of 1 frame per second and a total imaging period of 2 minutes, we were able to visualize CyPNs that moved on microtubule filaments. One example is shown in supplementary material Movie 5 and as still images in Fig. 3D. In this particular example, an YFP-PML-III-containing particle is observed to move in two consecutive short bursts along two microtubule filaments running in different directions.
The nuclear localization sequence of PML is required for CyPN targeting
Several different isoforms of PML are expressed in human cells as a result of alternative splicing (Jensen et al., 2001). The different splice variants contain a tripartite TRIM domain (comprising a RING-finger, two B-boxes and a coiled-coil) in their N-terminus and a variable C-terminus that might contribute to isoform-specific functions (Fig. 4A). To assess the ability of different PML isoforms to target CyPNs, we studied the subcellular localization of PML-I, PML-II, PML-III, PML-IV, PML-V and PML-VII that were transiently expressed in U2OS cells. All isoforms, except the cytoplasmic PML-VII splice variant, were found to target CyPNs (Fig. 4B). Notably, the transiently expressed PML-III isoform appeared to be able to target CyPNs more effectively than the other nuclear isoforms (Fig. 4B).
To further examine a link between nuclear import and the ability of PML to form complexes with CyPNs, we mutated Arg486 and the Lys487, two amino acids known to be crucial for nuclear import (Duprez et al., 1999), to Ala (a mutant that we termed PML-IIInls) (Fig. 4A). This import-defective mutant was detected exclusively in the cytoplasm following transfection into U2OS cells, but no colocalization between PML-IIInls and cytoplasmic nucleoporins was detected in any of the cells examined (Fig. 4C). This suggested that the capacity of PML to target CyPNs is linked to its nuclear-import capabilities.
We also mutated the RING-finger domain of PML, because this motif is thought to be crucially important for several PML functions. To achieve this, we substituted two of the zinc-coordinating cysteines (Cys57 and Cys60) with Ser (Fig. 4A) (Shen et al., 2006). This mutant (that we termed PML-IIIringS) retained its capacity to target CyPNs, but induced an altered morphology and distribution of these structures (Fig. 4C,D). Most notably the PML-IIIringS mutant induced CyPNs that were generally larger in size, fewer in number and were commonly detected in cytoplasmic regions more distal to the nuclear envelope compared with the wild-type protein. Furthermore, live-cell analysis of YFP-tagged PML-IIIringS revealed that this mutant was completely impaired in its ability to form stable interactions with the nuclear membrane (Fig. 4D). Since a RING-finger domain containing Cys-to-Ser mutations might retain some zinc-binding activity, we also constructed a less conserved ring finger mutant (PML-IIIringA) where Cys57 and Cys60 were replaced by Ala (Fig. 4A). The subcellular distribution of PML-IIIringA was found to be indistinguishable from that of PML-IIIringS (Fig. 4C).
Finally, we analyzed the cytoplasmic distribution of a SUMOylation-defective PML-III protein that contained Lys-to-Arg substitutions at Lys65, Lys160 and Lys490 (a mutant that we termed PML-IIIsumo) (Fig. 4A). This mutant colocalized with the cytoplasmic CyPNs in a manner that was comparable with that seen for wild-type PML-III (Fig. 4C). Thus, PML SUMOylation appears to be dispensable for CyPN formation.
Loss of PML causes increased levels of nucleoporins in the cytoplasm
We next assessed the effect of PML loss on nucleoporin distribution. For this purpose, we transfected U2OS cells with two different siRNAs specific for PML and a siRNA designed to target the firefly luciferase gene as a control. The two PML-specific siRNAs, but not the control siRNA, caused downregulation of PML expression and a concomitant increase of nucleoporins in the cytoplasm (Fig. 5). This result suggests a functional role of PML in regulating the cytoplasmic levels of nucleoporins. The increase of cytoplasmic nucleoporins was not due to alteration in cell-cycle distribution, because analysis of PML-depleted and control cells by laser-scanning cytometry revealed similar cell-cycle profiles (Fig. 5, right panels). Notably, the phenotype of PML-depleted U2OS cells reported here is reminiscent of that previously seen for Nup98-negative cells (Wu et al., 2001).
CBP targets CyPNs and MAPPs
To determine whether other proteins, in addition to nucleoporins and PML, have the capacity to target CyPNs, we tested a number of different antibodies against nuclear proteins for their ability to react with these cytoplasmic compartments. Among the antibodies tested were antibodies specific for MDM2, CyclinB1 (CCNB1), CyclinE (CCNE1), SUMO1, cdc2, Daxx, BLM, CBP, p21, CyclinA (CCNA2), OGG1, INI1/SF5, Rad51, RARα and MLL. In agreement with previous reports (Dellaire et al., 2006; Everett et al., 1999), the PML-NB-resident portions Daxx and SUMO1 were readily detected in PML-NBs but were not observed to colocalize with MAPPs or with PML-containing cytoplasmic particles (data not shown). The majority of the other antibodies that we tested did not reveal any affinity for CyPNs, suggesting that the ability to target CyPNs is restricted to a small group of proteins and is not a general characteristic of proteins containing a nuclear-targeting signal. The only protein in addition to PML and nucleoporins that we were able to detect within CyPNs by using the antibodies mentioned above was the transcription coactivator CBP. Interestingly, this protein was also readily detected within MAPPs (Fig. 6). A cytoplasmic association between PML and CBP was also noted in a previous study in which CBP and an exogenously expressed nuclear-import-defective mutant of PML were found to colocalize within cytoplasmic subdomains (Bellodi et al., 2006).
CyPNs are targeted by the PML-RARα fusion protein
Previous studies have revealed a more dispersed distribution of PML and other PML-NB constituents in APL cells compared with normal cells, an effect that was attributed to expression of the oncogenic PML-RARα fusion protein (Dyck et al., 1994; Koken et al., 1994; Weis et al., 1994). To determine whether this protein chimera also has the capacity to alter the morphology of CyPNs, we overexpressed PML-RARα in U2OS cells and subsequently analyzed the distribution of nucleoporins and the expressed fusion protein by immunofluorescence. Using antibodies targeted to both the PML and the RARα moiety of PML-RARα, we detected cytoplasmic clusters of nucleoporins and the expressed fusion protein in 15-20% of the transfected cells. Notably, the number of CyPNs was frequently observed to be markedly higher in PML-RARα-transfected cells compared with untransfected cells (Fig. 7A).
We also examined the APL cell line NB4 for the presence of CyPNs. This cell line is known to exhibit a dispersed PML distribution in the nucleus because of expression of PML-RARα, and cells regain prominent PML-NBs in response to differentiation-induced treatment with all-trans retinoic acid (ATRA) (Dyck et al., 1994; Koken et al., 1994; Weis et al., 1994). In untreated NB4 cells, we detected prominent CyPNs in more than 30% of the cell population. Moreover, by culturing these cells in the presence of ATRA, which is known to cause degradation of the PML-RARα fusion protein, we observed a gradual decrease in the number of cells containing detectable CyPNs. In addition, CyPNs in ATRA-treated cells appeared smaller than those detected in unstimulated cells (Fig. 7B). Thus, in contrast to the nuclear PML bodies, the morphology of CyPNs is not disrupted by PML-RARα expression.
The data presented in this study show that two proteins – PML and CBP – which have roles in regulation of gene expression, become stably associated with cytoplasmic nucleoporins during the mitosis-to-G1 transition. These cytoplasmic protein assemblies, the CyPNs, have the ability to move on the microtubular network, and they become stably associated with the nuclear membrane if they come into contact with the nucleus. Furthermore, CyPN formation is not supported by the cytoplasmic PML-VII splice variant, and the ability of PML to target these structures depends on its nuclear-localization sequence. Thus, despite the cytoplasmic localization of CyPNs, they might contribute to nuclear functions.
The formation of CyPNs might be transitionally linked to MAPPs, which represent a cellular compartment specific for the mitotic phase of the cell cycle (Dellaire et al., 2006; Everett et al., 1999). This is suggested by the finding that CBP, the only non-nucleoporin protein in addition to PML that we so far have been able to detect within CyPNs, also accumulates within MAPPs during mitosis. In addition, the formation of CyPNs during early G1 of the cell cycle was greatly stimulated by a preceding mitosis, suggesting the involvement of mitotic proteins and/or structures for their formation. Thus, PML might form a complex with CBP (and possibly other proteins) within MAPPs during the mitotic phase of the cell cycle, and subsequently, following completion of mitosis, might become stably attached to nucleoporins. A contributing role of MAPPs to the formation of cytoplasmic PML particles has also been proposed in previous reports (Chen et al., 2008; Dellaire et al., 2006).
The ability of PML to become linked to cytoplasmic nucleoporins in early G1 cells appears to be critically dependent on its nuclear-targeting domain, because both the cytoplasmic PML-VII isoform, as well as the nuclear import defective PML-IIInls mutant, failed to accumulate within CyPNs. This argues that PML is capable of associating stably with cytoplasmic nucleoporins by interacting directly with components of the nuclear pore complexes that mediate its nuclear import. The PML protein could therefore potentially become targeted to these cytoplasmic compartments by interacting with import adaptor proteins, such as importin-α or importin-β. Consistent with this notion, previous studies show that both of these import receptors are present in nuclear pore complexes of cytoplasmic annulate lamellae in Xenopus egg extracts (Cordes et al., 1997; Miller and Forbes, 2000). However, since PML contains an unconventional nuclear localization signal that does not match the consensus of any of the nuclear localization motifs that currently are known to bind import factors (Duprez et al., 1999), it might be equally possible that the nuclear-targeting sequence of PML contacts other components of the nuclear pore complex. In this respect it is of interest to note that CBP, the other CyPN constituent discovered in this study, has been reported to interact directly with nucleoporin-specific FG repeats (Kasper et al., 1999). Further studies should determine the precise protein interactions that take place between the nuclear-targeting domain of PML and components of the nuclear pore complexes.
The dependency of the PML nuclear-targeting sequence for association with cytoplasmic nucleoporins might also indicate that CyPNs represent nonfunctional complexes that form because of fortuitous interactions between PML and nuclear-import receptors present on fully assembled cytoplasmic nuclear pore complexes. However, several findings made in the present study suggest that cotargeting of PML and nucleoporins to common cytoplasmic compartments reflects a functional interaction between PML and constituents of the nuclear pore complexes. First, the PML-IIIring mutant, which contains a disrupted RING-finger domain, induced the formation of morphologically deformed CyPNs, which, in contrast to CyPNs containing wild-type PML-III, were impaired in their ability to dock at the nuclear membrane. Second, siRNA-mediated depletion of PML caused a considerable increase in the levels of cytoplasmic nucleoporins, suggesting a functional role of PML in regulating the balance between cytoplasmic versus membrane-bound nucleoporins. Last, during the course of this study, more than 15 different proteins were examined for their ability to target CyPNs, and only two of these (PML and CBP) could be detected within these compartments. Thus, although it is expected that other proteins in addition to those identified in the present study are present within CyPNs, these structures appear to be highly selective for a relatively small group of nuclear proteins and do not generally attract proteins that contain a nuclear localization signal.
Since both PML and CBP are known to be involved in various aspects of gene expression, this might indicate a role of CyPNs in transcriptional regulation. This idea is consistent with several studies demonstrating a role of nuclear pore complexes in the regulation of gene expression. Most notably several studies in yeast have demonstrated activation of gene expression following the recruitment of genetic elements from the interior of the nucleus to nuclear pore proximal sites at the nuclear periphery (Casolari et al., 2004; Menon et al., 2005; Schmid et al., 2006; Taddei et al., 2006). In a recent study performed on human cells, several binding sites for the nucleoporin Nup93 were mapped to regions of transcriptional regulation on chromosomes 5, 7 and 16, indicating a similar role of nuclear pore complexes in mammalian gene expression (Brown et al., 2008). An intriguing possibility is that some protein complexes that participate in transcriptional regulation might be routed to the nucleus by a mechanism that involves preassembly of nucleoporins and transcription complexes in the cytoplasm and subsequent exposure of these transcription factors to the nuclear environment following insertion of new nuclear pore channels into the nuclear envelope.
It is also possible that the observed colocalization between PML and cytoplasmic nucleoporins reflects a role of these proteins in nucleocytoplasmic transport. In agreement with this, PML has been implicated in the export of selected mRNA species involved in cell-cycle regulation through an interaction with the translation initiation factor eIF4E (Cohen et al., 2001; Culjkovic et al., 2005; Culjkovic et al., 2006; Lai and Borden, 2000).
A third possibility could be that CyPNs represent sites of protein degradation and that the presence of nucleoporins within these structures in early G1 phase reflects an excess of nuclear pore complex constituents that were not incorporated into the progeny nuclei following completion of mitosis. This theory is consistent with previous studies supporting a role of PML in protein degradation (Chai et al., 1999; Janer et al., 2006). Furthermore, a role of PML in degrading excessive nucleoporins is in agreement with the observed increase of cytoplasmic nucleoporins in PML-depleted cells.
Although it has long been known that the cytoplasm contains PML and nucleoporins that are readily visualized by fluorescence microcopy, very little functional information exists regarding the cytoplasmic life of these proteins. The data presented here reveal a dynamic interplay between nucleoporins, the tumor suppressor proteins PML and CBP, and the nuclear membrane. Furthermore, several of the CyPN-resident proteins, including Nup98, Nup214, PML and CBP are encoded by genes that are at the break points of chromosomal translocations that recurrently are identified in AML blasts. Further research into the composition and function of CyPNs might therefore provide new insight into the molecular mechanisms that determine the development of this type of cancer.
Materials and Methods
Cell-lines and cell-cycle synchronization
The cell lines U2OS (human osteosarcoma) and HaCaT (human keratinocyte), HeLa (human cervical cancer) and NB4 (human promyelocytic leukemia) were maintained in Iscove's modified Dulbecco's medium (IMDM) (BioWhittaker, Belgium) containing 10% fetal calf serum (PAA, Austria). MCF7 cells were grown in RPMI medium (BioWhittaker) containing 10% fetal calf serum. Human embryonic (HE) fibroblast cells were obtained from the National Institute of Public Health (Oslo, Norway) and grown in Dulbecco's modified Eagle's medium (BioWhittaker) with 10% fetal calf serum. Synchronization by serum starvation was performed by culturing HaCaT cells on coverslips for 72 hours in serum-free medium followed by release into the cell cycle by adding fresh pre-warmed medium containing 10% serum. Synchronization of cells in the mitotic phase of the cell cycle was achieved by culturing HaCaT cells on coverslips for 16 hours in the presence of 60 ng/ml nocodazole (Calbiochem, CA) and subsequent cell-cycle release by adding pre-warmed drug-free medium. ATRA was purchased from Sigma and used at 1 μM.
Antibodies and immunofluorescence
The antibodies used were mouse anti-PML (PG-M3), rabbit anti-PML (H238) and rabbit anti-CBP (A-22) from Santa Cruz, mouse anti-Nup153 (QE5), Mab414, mouse anti-His (HIS.H8) rat anti-Nup98 (2H10) and rabbit anti-Nup214 (Ab40797) from Abcam and mouse anti-HA (12CA5) from Roche. Fixation and immunofluorescence labeling of cells was performed as previously described (Jul-Larsen et al., 2004).
Plasmids, siRNAs and transfection
His-tagged PML isoforms I to V cloned into pcDNA3 were kindly provided by Kun-Sang Chang at the University of Texas (Xu et al., 2005). His-tagged PML-VII was derived from pcDNA-PML-V by first introducing a ClaI site at nucleotide positions 1345-1350 by silent mutagenesis and subsequently placing a synthetic ClaI-XbaI linker containing the PML-VII specific C-terminal sequence into the ClaI-XbaI site. Plasmids expressing YFP-PML-III or CFP-PML-III were kindly provided by Karien Wiesmeijer and Roeland Dirks at Leiden University Medical Centre in the Netherlands. The plasmid expressing YFP-tagged α-tubulin was kindly provided by Michaël Marie at the University of Bergen, Norway. The pCNA-PML-RARα was a kind gift from Pier G. Pelicci at the European Institute of Oncology, Milan, Italy. The mutants PML-IIInls (R486A; K487A), PML-IIIringS (C57S; C60S), PML-IIIringA (C57A;C60A) and PML-IIIsumo (K65R; K160R; K490R) were generated by using the QuikChange kit from Stratagene.
Plasmid transfections were performed using the FuGENE6 transfection reagent from Roche. In all experiments, cells were analyzed or fixed at 12-24 hours following transfection. Transfections with siRNAs were performed using Oligofectamine (Invitrogen, CA) according to the manufacturer's instructions. Cells were fixed and processed for immunofluorescence at day 3 after transfection. siRNA oligos used were: PML siRNA1, 5′-GUUUCUGCGCUGCCAGCAAtt-3′ (Eurogentec, Belgium); PML siRNA2, 5′-AGAUGCAGCUGUAUCCAAGtt-3′ (Ambion, TX); control siRNA (against fire fly luciferase), 5′-UCGAAGUACUCAGCGUAAGtt-3′ (Eurogentec).
Laser-scanning cytometry (LSC) and quantification of CyPNs
To determine the cell-cycle profile of asynchronous and synchronously gowning cells on coverslips DNA was stained with TO-PRO-3 (Invitrogen), and subjected to laser-scanning cytometry (CompuCyte, Cambridge, MA). CyPN quantification was performed by immunofluorescence labeling using antibodies against Nup153 and PML. For each sample 6-8 randomly selected microscopic fields were captured by using a Leica DMRXA fluorescent microscope equipped with a ×63 oil-immersion objective and a DC500 camera. Quantification was performed on merged Z-stacks of 8-12 images comprising the entire cell, and CyPNs were scored positive if the localization of Nup153 and PML labeled particles overlapped. Both the percentage of cells containing CyPNs as well as the average number of CyPNs per cell was calculated. Quantification of CyPNs in transfected cells was performed by analyzing a total of 100 randomly selected transfected cells (identified by His-tag-positive staining) that had been labeled with anti-His and anti-Nup153 antibodies. Cells were scored positive if His- and Nup153-positive cytoplasmic particles colocalized.
Confocal microscopy and live-cell imaging
Confocal microscopy images were obtained using a Zeiss LSM 510 Meta laser confocal microscope (Jena, Germany) equipped with a ×63 oil-immersion lens (Zeiss). Live cell imaging was performed using an Ultraview spinning disc confocal microscope from Perkin Elmer (Wellesly, MA) attached to a ×63 oil-immersion lens. Cells were grown in 6 cm glass bottom dishes from MatTek (Ashland, MA) and transfected 1 day before imaging. During imaging, cells were maintained at 37°C and 5% CO2 using an environmental chamber. For short sequences, Z-stacks of 1-3 images were collected every second for 2 minutes. For longer periods of imaging (30 to 40 minutes total imaging time) Z-stacks of 8-12 images were collected at intervals of 30 seconds. Exposure times for each of the images varied from 30 mseconds to 60 mseconds. Velocity diagrams were obtained by determining the shortest distance between a YFP-labeled particle to the nuclear membrane using the measuring tool in Adobe Photoshop.
Supplementary material available online at http://jcs.biologists.org/cgi/content/full/122/8/1201/DC1
This work was supported by the Cancer Gene Therapy Program funded by the Norwegian Health Department and Helse-Vest. Support from the Norwegian Cancer Society and the Norwegian Research Council is also acknowledged. Live-cell imaging was performed at the National Technology Platform Molecular Imaging Center, supported by the functional genomics program (FUGE) in the Research Council of Norway.
↵* These authors contributed equally to this work
- Accepted December 2, 2008.
- © The Company of Biologists Limited 2009


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May 26, 1924 – Feb. 17, 2019
It is with great sadness we announce the loss of Zela Viola Rutledge on February 17, 2019. Zela passed from natural causes peacefully while resting in her home of 60+ years.
Zela was born at her Aunt Vern Goetjen's home on May 26,1924 to Winford A. Tomson and Lola O. Tomson (Goetjen). After only 5 days rest, the Tomson family returned to their farm on the Salmon River. (Which when sold, was eventually turned into Pixieland.)
As Zela grew she learned the essentials of farm life. She milked cows, tended gardens, canned for the winter, fished, and picked fruit. While this was difficult work, it established the brave, "we can do anything" personality that we all knew and loved.
As a young woman (1930ish) Zela worked outside the home at a number of different establishments to include "The Halls Crab Pot", Otis Chowder house, Taft High School, Lakeside Theater, Ocean Caves Store, and Nelscotts' Grocery. She also worked at "The Logs" (a dance hall here in Gleneden Beach). There she met her husband Dale L. Rutledge whom she married at the Chapel by the Sea in 1949. Dale Sr. unfortunately left us in 2002 from a car accident. She also had a second son, Tom Rutledge, who served honorably in Vietnam but passed in 2011.
Zela was a vital component to the Lincoln County community. She was contracted by Cascades West Senior Services for 24 years as an advocate for seniors and people with disabilities. Upon retirement she filled her calendar with volunteer work in programs such as Meals on Wheels, County Fairs and her beloved Senior Center.
Her efforts earned her a number of different awards to include the Newport County Fair County volunteer the year (1998), and Senior Services volunteer of the year (2012). She also received several letters of recognition, certificates other accolades from various State Governors acknowledging her exceptional contributions.
She is survived by Dale and Sherry Rutledge (son and daughter-in-law), her grandson Adam Rutledge, her wonderful sister Marcia Berry (Gotjen) and 2 beautiful nieces Bonnie Kessler and Peggy Gesik.
A Celebration of Life will be held Saturday, April 13th at 1Pm in Eden Hall, Gleneden beach. For those considering bringing flowers, may we suggest donating to Newports' Meals on Wheels site. They are located at 20 S.E. 2nd St., Newport OR, 97365 and their phone number is (541)574-0669.
To send flowers to the family or plant a tree in memory of Zela V Rutledge, please visit our floral store.


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I saw some great wreaths made out of book pages by Connie Govea Stuart in Somerset Life a few months ago.
I wanted to make a wreath from one of my old Bibles that was falling apart. I decided to make a wreath using the pages from the book of Exodus.
I used a verse from Exodus as the main accent for the tag and then used the entire book of Exodus to fill the wreath.
I used a wooden embroidery hoop for the frame and wrapped it in ribbon. Next I rolled each page on a pencil and then flattened it with my hand. I hot glued the pages around the hoop and used a pretty silk ribbon for a hanger. I then added the tag and some ephemera for interest and some buttons.
I used 4 pages and folded them into fans, and then folded those fans in half. By gluing the sides together I had a perfect, full rosette to add in the center of the wreath. I adhered this last, followed by a dried flower. Lastly, I sponged some distressing ink around the circumference of the wreath to darken the edges.


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Astronomers found a 'cold super-Earth' less than 6 light-years away — and it may be the first rocky planet we'll photograph beyond the solar system
- Astronomers think they've found a "cold super-Earth" exoplanet orbiting Barnard's star.
- Barnard's star, less than six light-years from us, is the closest single-star system to our sun.
- The new world, called Barnard's star b, or GJ 699 b, is at least 3.2 times as massive as Earth.
- It orbits in its parent star's "snow line," a region at the edge of a star'shabitable zone where scientists suspect most rocky planets form.
- This roughly Earth-size exoplanet may be the first to be photographed by a new generation of powerful telescopes.


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Are you looking for a physical item in the Plains Public Library? Search our library catalog to see what is available and place a hold.
Want to download an E-Book or E-Audiobook to use on your computer, phone or tablet? Search our collection of downloadable items.
Looking for local, regional or national community resources? Let us point you in the right direction.


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My Dear Friends,
I want to welcome you wholeheartedly to Open Gate Sangha's upcoming silent retreat. Retreat is my favorite forum to teach in because it is an opportunity to focus all of our time and attention in a sustained and devoted way toward responding, with the full measure of our hearts and minds, to the great spiritual instinct flowing within us all. This shared commitment makes retreat a powerful transformative environment.
Although the spiritual instinct is experienced in its own unique way within each one of us, it originates in the very ground of our universal being, and is an instinct to awaken to the timeless and measureless reality of our true nature─a true nature that encompasses the paradoxical qualities of transcendence, wholeness, and in-formed embodiment. This instinct to awaken to, and become conscious of, our true nature is as much a part of us as breathing. For our true nature seeks not only its full realization but also its in-formed and embodied expression in time and space.
I encourage you to come to retreat with as much of an open mind and open heart as you can. Whether this is your first retreat with me (welcome) or your latest among many, please show up ready and committed, and with a beginner's mind free of expectations or preconceived ideas of what this retreat has in store for you. Over two decades of teaching retreats has taught me that each and every retreat is unique and has a mysterious life of its own. So let us all come to retreat willing to live on the edge of discovery, and allow the inherent instinct of awakening to reveal all that it desires within us.
Retreat is also a commitment to the structure and container of retreat, as well as to the guidelines that help each of us to silently support one another and maintain the integrity of the retreat environment. This shared regard and respect for the dignity of one another and for the retreat structure is an important part of being on retreat, because we are all here both to respond to our own spiritual calling, as well as to silently support one another with great charity, courtesy, and kindness.
And finally, retreat is a time to retreat from the endless ways that we distract ourselves from the deeper and wider horizons of ourselves and of life. Many of our technological devices function as much as implements of distraction and addiction as they do to helping us navigate the practicalities of daily living. So please enter into retreat fully committed to being here, and tie up whatever loose ends you can so that you can give the full measure of your devotion to what spiritual retreat truly is and to why we gather together in sacred community.
I look forward to sharing this wonderful and rare opportunity to be with you on retreat, in mutual love and devotion to the truth at the heart of being. May all beings everywhere benefit.
With Great Love,


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Software Company Marketing Plan - In reviewing the two examples above, you could see that each organisation has precise wishes from advertising based totally on each their marketplace and enterprise goals.? however, both have one component in not unusual and that's extensive investment in "marketing foundation".? if you have a terrible fine website, an uneventful pitch deck, or sloppy collateral, you'll be throwing your cash down the drain on advertising or public members of the family.? if you put money into nothing else, build a solid foundation in your advertising residence first. Our 2d company is a privately-owned it services issuer which simplest works with groups in a 200-mile radius from its most important office.? in its marketing strategy, the yr 1 revenue projection is $3m and the 12 months 2 projection is $4m.? their prospects are lots more secure with generation and searching out professional offerings vendors on-line.? they regularly have an pressing server trouble or some other it calamity that must be repaired or the enterprise can not feature.
Software Company Marketing Plan Popular ... Picture Of Software Company Marketing Plan Solutions
Software Company Marketing Plan Creative Binary Plan, Software Development By Omega Software, Issuu Galleries
In case you're absolutely misplaced on in which to begin with a advertising plan, this guide assist you to define your audience, discern out a way to attain them, and make sure that target market turns into dependable customers. Via making use of a flywheel-like strategy on your very own advertising efforts, you essentially remove the burden of applying new techniques to every person advertising campaign. As a substitute, your earlier efforts benefit momentum through the years, and dispel chronic electricity into anything you put up next.
Software Company Marketing Plan Creative Brandollo Is A, Software That Designs Marketing Plans, Small Businesses Pictures
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There's one small problem, though: your boss needs you to put in writing and gift a content material marketing plan to her, however you've never done something like that before. You don't even understand wherein to begin. A successful e-book release is a high instance of information-driven content material advertising. Using facts to optimize your content material method spreads greater consciousness on your ebook, gets greater people to subscribe to your content, converts more subscribers into buyers, and encourages extra consumers to suggest your ebook to their friends. When shane snow began promoting his new e book dream crew, he knew he needed to leverage a statistics-driven content strategy framework. So he chose his favourite one: the content method waterfall, that is described by way of monetary instances as a model used to create a gadget with a linear and sequential technique. To get a higher concept of what this indicates, test the diagram beneath:.


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Manuel P. Alvarez
General Counsel
Affirm, Inc. Former CFPB Enforcement Attorney
Manny Alvarez serves as General Counsel and Chief Compliance Officer to Affirm, Inc., a San Francisco-based technology start-up providing online point-of-sale consumer financing solutions. He oversees the company's day-to-day legal and compliance affairs, including negotiating and drafting commercial contracts, managing corporate governance, and advising the business units on marketing, IP protection, and regulatory compliance. Before joining Affirm, Manny was a "Founders Club" member of the Consumer Financial Protection Bureau (CFPB), a federal agency created by the Dodd-Frank Wall Street Reform and Consumer Protection Act of 2010. He was the lead attorney in CFPB v. Castle & Cooke Mortgage LLC, et al., the first-ever enforcement action of the Mortgage Loan Originator Compensation Rule promulgated after the 2008-2010 foreclosure crisis. Manny is also an alumni of the Consumer Law Section of the California Attorney General's Office, where he helped achieve a $6.5 million settlement against the former-COO and the former-CEO of Countrywide Financial Corporation for their roles in the company's predatory mortgage lending practices. Manny began his career with Sonnenschein Nath & Rosenthal LLP representing insurers and other financial institutions in a variety of matters ranging from breach of contract to unfair competition claims. He holds a JD from UC Hastings College of the Law and a BA from Cornell University.


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It's hard to be a bachelor in Hollywood with all the ladies trying to swoon over every single Hollywood star. Today we have a fresh saga of Hollywood bachelors. The ball is now in your court, ladies! All of you is good enough to make all these Hollywood hotties bow down and put a ring on the finger!
26. John Boyega, 26
John Boyega, born John Adedayo B. Adegboyega, became a household name for his role as Finn in the 'Star Wars' franchise. His smile and charm are unquestionable. And soon some lucky girl is bound to snatch this Englishman from the volatile Hollywood bachelors shelf. His specialty seems to be in Science fiction films. So hey, ladies, let's go to the science world! The perfect match is near.
25. Zayn Malik, 25
We keep dreaming and consider him to be the most gorgeous Hollywood bachelor. But, of course, there is a girlfriend in tow. In case you didn't know, Zayn Malik is seriously dating Gigi Hadid. Our bet is on his age. At 24 it's unlikely that the girlfriend will be taken up to the wife level any time soon. Sure, the former One Direction member is still unattached.


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Make Your Guest Bedroom A Cozy Place With These Awesome Decoration Tips
A guest bedroom is an important place of a house as this room represents your taste and status to your guests. That's why it's really important to decorate your guest bedroom nicely and present it as a cozy place to the guests. But, we often can't decorate the room properly. But don't worry; we are here today with some easy and simple guest bedroom design tips. Follow these; hope, these will help you a lot to make the room better-
- Place 2 separate Beds:
Source : rackcdn.com
Most of the times, more than one person come to visit. And it's a bit annoying if they have to sleep in the same bed. So, it's a better idea to put 2 separate beds in the room. If you have enough place then get 2 twin beds, but if don't; then you may consider single. The queen size beds are highly recommended for the bed as they are large in size. You also should use a good queen size memory foam mattress for the bed in order to get a better result. Additionally, you may consider adjustable beds as they're very popular nowadays.
- Attach a Big Mirror:
Source : thediyplaybook.com
Attaching a full-length mirror in the guest bedroom is a great idea. It increases the beauty of the room. Additionally, a full-length mirror is a pretty good & effective trick to make the guest bedroom feel airier and larger as well. And remember, though you have a smaller space of the room; try to put a full-length mirror, even a narrow one.
- Comfortable Mattress:
Source : comfortinnstatenisland.com
When it's all about a bedroom, the bed is the major priority. A comfortable bed is everyone's expectation in the sleep time. So, you must get a comfortable and cozy mattress for your bed(s). There are a lot of modern mattress types available in the market with advanced features and abilities. Some of the suitable mattress types for your guest bedroom are- the nectar mattress, the purple mattress, the hybrid mattress, the cloud mattress, the memory foam mattress etc. Try the mattresses and get the best one for the bed(s).
- Art Grouping & Paint:
Source : colourdrive.in
The paint of any room is the key way to look beautiful. Paint your guest bedroom with a beautiful and attractive color paint. You may also consider wall art and art grouping for the walls of the room in order to make it more beautiful. Put some gorgeous art groups on the walls of the room for display. Trust me; it'll increase the beauty of the room.
- Bedside Storage, Dresser & Closet:
Source : i.pinimg.com
Adding the closet and a bedside storage to the guest bedroom adds extra value to the room. The closet is very necessary for the guest as they need to change the clothes and store them (if they stay longer). Additionally, dresser is required in every bedroom. Put a dresser too. It's one of the must-have furniture pieces to the bedroom, especially for the women. And the bedside storage is needed for putting the pieces of small stuff on it. On the other hand, if you choose a higher bed and higher mattress foundation, then you'll get extra space under the bed. Consider it.
- Add a Desk or Vanity:
Source : i.pinimg.com
Your guest may need to do some official works or read a book in the room. In that case, a desk or a vanity is a very effective furniture piece to the room. And remember, don't forget to include some convenient & essential item to the desk or vanity such as paper, pen, pad, phone charge, magnifying glass or anything else that might be needed. You may also put a coffee maker in a corner. Your guest may like it too.
- Bedside Lighting:
Source : home-designing.com
In a bedroom, bedside lighting is must. Install a great and attractive bedside lighting system in the guest bedroom. The lighting system also increases the beauty of the room.
Just try to use every possible space of the room along with leaving some free space. Good luck!


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As pleached hedging, the stunning autumnal colour and large deeply lobed leaves, really sets this pleached tree apart from the rest, but needs fertile and well drained soil, disliking thin chalk. Smooth bark
'Pleached' trees are effectively hedges on stilts and create a superb way to screen windows, or indeed whole gardens from neighbours or eye sores. As such they are a cost effective and very natural way of screening, being far cheaper and more instant than, say building a brick wall, which often needs planning permission.
A wide range of trees are grown as ready pleached trees, and can be evergreen or deciduous.
They are usually available in three styles:
- 'Standard' with a 1.8m (6') clear stem or trunk before the trained canopy starts. Usually the canopy is a square 1.2m (4') x 1.2m but larger ones are sometimes available.
- 'Half standard;' with a 0.9m (3')-1.2m (4') clear stem before the canopy starts.
- 'Panel' where the canopy is trained almost from the ground to two or even three meters in height'
With these different styles and the various species that are available, the options are numerous. But with the time taken to grow and train these trees to create 'the instant hedge on stilts,' sourcing the trees is offered as a bespoke service.


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Colin Matthew Halden
"Memories are precious, they don't go away. We think of you always and not just today."
Date passed: 28th of September 2019
Funeral date: 9th of October 2019
"Memories are precious they don't go away, we think of you always and not just today."
Colin sadly passed away at home on 28th September, aged just 40 years.
Colin leaves behind a daughter Malanie, parents Terry and Alison and brothers Barry and John. Colin will be dearly missed by all his family and friends.
Colin attended Pebble Brook Primary school and after his education he went on to work for a company in Market Drayton called Palethorpes.
He loved animals and gardening and was a kind hearted and likeable lad.
His funeral will take place on Wednesday 9th October in the Crematorium Chapel, Crewe at 10am, followed by cremation.
For any further information regarding Colin's funeral please contact our funeral home on 01270 584447.
1 Condolence
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Because the advisor-student relationship is so beneficial to the student's academic progress and career planning, MyPublicHealthDirect students are assigned an advisor immediately upon acceptance to the program. Students will meet virtually or in person with their advisor before beginning the program to discuss course enrollment and sequencing and answer any questions about how to register for courses. This advisor will be in contact with the student throughout the completion of the program.
Student Organizations
Participating in student organizations builds career skills and professional networks. Student groups in the School of Public Health-Bloomington welcome online students' participation.
Eta Sigma Gamma - Nu Chapter
Eta Sigma Gamma (ESG) is a national professional health science honorary organization.
Members of REACH seek to empower all students within the Indiana University School of Public Health-Bloomington to grow and learn in an environment filled with culture, diversity and understanding to support personal and professional understanding of culture and its impact on public health.
SPH Engage
SPH Engage is a school-wide program focused on assisting students in developing connections to their coursework, peers, leadership development, intentional engagement, and personal goals. We work with any student with an interest in any aspect of the School of Public Health.
Events and Activities in the School of Public Health
Whether you live in Bloomington or Bologna, you can participate in any number of lectures, career fairs, and special events in the School of Public Health. Many events are available via recordings or live teleconferencing. Visit the SPH Calendar of Events.
Career Services
All MyPublicHealthDirect students have complete access to career resources and student services. Services include: IU's world class library, career exploration, job search assistance and resources, resume and cover letter development, interview preparation, internship coordination, workshops, employer information sessions, on-campus and online interview opportunities, online networking events, and virtual job fairs. Students are encouraged to stay in touch with program staff and Career Services for additional support after completing the program.


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By Tom Morris for The New York Times - 2 October 2018
The artists Peter McGough and David McDermott have built a shrine to the playwright and poet that will also host events held by the L.G.B.T. community.
"Who wouldn't want to get married under the statue of Oscar Wilde?" asks the artist Peter McGough, standing in front of an altar that surrounds a wooden rendering of the 19th-century Irish playwright and poet. In 1895, Wilde was imprisoned on charges of sodomy and gross indecency, following accusations made by the father of his lover, Lord Alfred "Bosie" Douglas. Wilde "stood up for himself in the courts, he went to jail and then he was destroyed," says McGough. "What he went through was very Christlike."
Opening this week in a Victorian South London church, the "Oscar Wilde Temple" is the first London show for McGough and his long-term artistic (and former romantic) partner, David McDermott. Originally mounted in New York, last year, the immersive installation takes over the premises of the nonprofit arts organization Studio Voltaire — located in a former chapel — where it will remain for the next six months. "Why not let people find solace in a place where they're not being condemned?" asks McGough.
Gay rights and the AIDS crisis have been constant themes in the pair's work. While "Oscar Wilde Temple" is a camp high-five for progress, it is a politically charged indictment, too. The painting "A Friend of Dorothy, 1943" features slurs that the artists have been called. Another, showing a luminous spiral radiating from the center of the canvas, bears the title "Advent Infinite Divine Spirit," offering an alternate meaning for the acronym AIDS. Both works date from the '80s. There are also contemporary pieces: Displayed on either side of the altarpiece are 12 oil paintings of what McDermott and McGough identify as modern-day martyrs. These figures include not only icons of queer culture such as Harvey Milk and Alan Turing, but also lesser-known figures like Xulhaz Mannan, the founder of Bangladesh's first L.G.B.T. magazine, and Jody Dobrowski, a London bar manager, both of whom were killed in hate crimes.
The artists have restored the exhibition space back to its former Victoriana glory, by adding purple votive candles, heavy chandeliers and geometric floral wallpaper from the 1880s. In addition to the hand-carved Wilde statue at the altar, the temple is complete with new stained-glass windows depicting sunflowers and green carnations (a nod to a key prop in Wilde's play "Lady Windermere's Fan''). Paintings of archival newspaper cartoons of the author's trial are displayed to mimic the stations of the cross found in a traditional Catholic church.


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A burned out, cynical cop. A serial killer who loves the hunt as much as the kill.
Corrupt politicians in bed with a crooked Chief of Detectives.
At the center of it all is a beautiful young woman with a troubled past.
If you think its Los Angeles in the 1950's you're wrong.
It's the year 2454 and Capital City on the frozen planet of Beta Prime is no place for the timid. $0.99 on Kindle.
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|Thursday, 29 May 2008
Bangladesh: Justice is only for the little people
By GM Solaiman
I read news and opinion piece in Bangladesh newspapers related to corruption and people's perspective toward it. I read with a great amusement how some people stay cool and not even bother by the mountain of corruption. If media reflect any percentage of views in real ground, it is almost shocking how they show tolerance toward corruption. Some people took it as part of the life very well. Now that's a compliment. One probably will go crazy if he would not or can not take this as business as usual. Isn't Bangladesh a part of this civilized world? Is there any respect for justice in any part of the society in Bangladesh? Actually, there is. It is for the little people who must obey the law. It is the little people to whom justice is served. It is the little people who, with all the hardship in life, keep Bangladesh a part of the civilized world. Well, at least as of now.
Let me bring your attention to a recent court verdict. Md Shahid Mia, a technician from Titas Gas Transmission and Distribution Company, was sentenced to three years in jail for taking Tk 5,000 in bribe. Few local newspapers reported this in May 22, 2008.
"A special Dhaka court on Wednesday sentenced an official of Titas Gas Transmission and Distribution Company to three years in jail for taking Tk 5,000 in bribe."
"Convicted Md Shahid Mia will have to serve one more year in jail in failure to pay a fine of Tk 1 lakh. Judge Md Sirajul Haque also issued an order to confiscate the cell phone of Shahid."
"Ebadullah al Mamun, managing director of Quality Re-rolling Mills, filed the case against him with Shyampur police station on May 6 last year. According to case details, Shahid demanded Tk 5,000 for a utility connection. The Rapid Action Battalion arrested him."
Shahid Mia's wife was present in the court room. Shahid Mia hugged his wife to give her some comfort after the verdict. His lawyer Rehana Alam told him that this is the list possible punishment for the crime. It can not be reduced. This is for just taking 5000 taka (73 dollars) bribe. No other crime, corruption or illegal property involved.
There is nothing surprising here. He did the crime, so he got the punishment. It could have been any other civilized country. The criminals would get similar punishment.
Now I want you to take a moment and rethink this. Just 73 dollars of corrupt money can put you 3 years in prison. Even in Bangladesh, it can. Does people in Bangladesh realized it? I am sure some people do realize it. Shahid Mia and his family realized. Many more people like Shahid Mia realize it every day.
What about big fishes, do they realize? I am talking about those people who have taken millions of dollars in bribe along with other crime, corruption and illegal property. How many thousands years of imprisonment would they get in punishment? Well, they never did. Punishment is reserved only for the little people in Bangladesh. Those who acquired millions of dollars in corruption never faced any punishment. Shouldn't they get the punishment?
Is it too unfair to say that this punishment, as justified as it is, would be an insult to the justice system if the top criminals of the nation wonder free?
I read some opinion articles in few daily newspapers with lot of amusement. I don't really understand this. How could an educated person argue in favor of those corrupt criminals? How could they do it in a civilized society? Don't they have any shame at all? Apparently they don't have any shame. What could be the reason?
Could it be that these so called intellectuals are not belongs to this civilized world? Could it be that they some how lost the sense of what is wrong and what is right? Or, is it because that these so called intellectuals are beneficiary of the corrupt officials and politicians? Is it because that these so called intellectuals are the creation of the top corrupt circle of Bangladesh? Isn't it true that those who support the evils are indeed part of the same evil?
Is it possible that the people of Bangladesh can come out of the box of wrong doers and their evil intellectual propaganda machine? I certainly hope so.


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Tyrrell's incredible journey is one you'd be well advised to follow… A purveyor of elegant yet seductively psychedelic folk songs….' – Iain Shedden, The Australian
Story is at the forefront for troubadour Áine Tyrrell whose rich songwriting practice draws deeply on her Irish roots. Her latest offering 'Return to the Sea'was written and recorded in her homeland but mastered and crowdfunded with one boot in the red dirt of her adopted country of Australia. Fiercely independent Tyrrell is not one to bend to the demands of conventional production arrangements, and so with the help of Creative Arts Victoria, her long time musical producer Mark Stanley, and her international fan base, 'Return To The Sea' went rogue, recording in lounge rooms, front bars, old churches, and remote islands.
Return To The Sea has just been released with first single "In This House" gaining international attention already as a finalist with Honourable Mention in the 2018 International Songwriting Competition. The song has further aspirations then awards with the collaborative video for the song touching the hearts of teachers and being incorporated into the curriculum in schools across South Australia and New South Wales to reteach the history of colonisation. In This House along with 9 other tracks make an album is a treasure trove of contemporary narratives and musical sojourns with a solid respect for tradition and a passion for adventure and travelling to new lands, both real, and musical.
Tyrrell's passion proved to be inspiringly infectious with her Pozible Crowdfunding campaign raising over $18k in just three weeks to complete the project on her own terms. 'I have a true pirate spirit. It's in my bones. There's no ship I can't captain. Or at least try,' she says 'but you can't do it alone. You need a rebel crew!'
'I am Irish,' Tyrrell goes on to say, 'but there is a real sense of place in Australia in my music. It's not strictly Irish and it's not Australian. I am so proud of the musical heritage I come from. The sense of tradition musically is grounding, but tradition in its essence has boundaries, expectations, and ingrained rules. Leaving home made me push my music and myself out of that box. It has given me permission to break the rules,' she says. 'I have learned to draw from that deep well, but I value the freedom I have to express it in my way and I have Australia to thank for that.'
Her unique musicianship and an equally deft touch with a killer hook or a heartrending lament has attracted the attention of many celebrated musicians in Ireland and Australia including Glen Hansard who mentored her 2017 EP release 'Fledgling Fall'. Tyrrell's seductive, mournful voice, atop a stirring Celtic soul romp, is given a little extra finesse by her friend Hansard on her the single 'Don't Be Left Crying'. The song climbing to Number One on Ireland's national broadcaster RTE's Independent Music Charts on her first ever release in Ireland.
That's just part of the story that continues to unfold for the Australia-based Irish musician, Tyrrell on her extraordinary journey. The gypsy spirit runs strong in Tyrrell who recorded her first album 'Queen of Swords' with creative partner in crime, Stanley aboard her 1966 Bedford Bus through the South Australian desert and into the caves of the mining town of Coober Pedy. She spent 2017 on back to back musical odysseys across Europe, Ireland and Australia packed with guitars, banjos, tin whistles, and three kids aboard her bus. As if touring venues and playing world class festivals internationally wasn't enough for Tyrrell, she used the time in Ireland to record 'Return To The Sea'. The album is a musical journey across her homeland collaborating with Mark Stanleyand Karl Odlum (The Mary Janes), Liam O'Maonlaí (Hot House Flowers), Joe Doyle and Colm Mac Con Iomaire (The Frames), and Declan O'Rourke.
'Return To The Sea' is something of a homecoming both musically and physically as Tyrrell returned to the places and the people that made her including her father, Seán Tyrrell, one of Ireland's most revered and enduring folk singers.
'The ethos behind this album was coming back to find a source," says Tyrrell "My first album 'Queen of Swords' was very personal, a cathartic piece of art to be able to pick up the pieces of my life after a destructive relationship. It became a passage to freedom. 'Return to The Sea' is about standing in power, owning your own skin and making sense of the shared responsibility we have as humans. The album embraces stories that have inspired me to do more than just sit and hope for change. It is my call to arms. Many observations between Australia and Ireland are scattered through the tracks, but the one common thread is that together we rise in strength when one human experience can mirror and then shape our collective understanding and action."
Tyrrell's own story in itself is the stuff of quiet cinematic inspiration, a powerful example of overcoming adversity. Tyrrell recklessly disregards what is considered impossible and rewrites the book every step of the way. Her passion for justice and integrity has led to her supporting current Women's Rights and Indigenous Rights issues through performances, social media campaigning, song writing and public speaking engagements.
Tyrrell's passionate music draws from a number of styles and influences. Certainly traditional Irish folk is in her blood, but so too are elements of soul and rock 'n' roll. Her upbringing in County Clare and in the United States (her mother is American) and her new-found love of Australia also means she is drawing from many cultures in her writing.
The last two years have been huge for Tyrrell. In addition to her own massive touring schedule, she joined Paul Kelly, Shane Howard, Pauline Scanlon, Declan O'Rourke, John Spillane and her father on the national concert tour Exile, a line-up of outstanding Irish and Australian artists who came together for a celebration of Irish influence in Australia, creating a rich tapestry of stories, imagery and music. 2016/17 saw Tyrrell perform successful headline tours around Australia, Europe and Ireland as well as performing at Woodford Folk Festival, Adelaide Fringe, Mullum Music Festival, Cygnet Folk Festival, many others and Electric Picnic in Ireland. She has earned the reputation of being an unmissable live act.
This year the Queen of Swords stakes her claim and invites you to share the stories of her journey, and her soundtrack to salvation. Her forthcoming musical offering, 'Return To The Sea' is a call to arms, a siren's wisdoms and warnings, and most importantly the soundtrack of a woman who walks her own beat.
- "Áine Tyrell delivers anthems for humanity with her new album Return to the Sea" – Hhappy Mag 2019
- "Áine Tyrrell's (Return To The Sea) a psych-folk force… she defiantly stakes a claim to ownership from start to finish" – Irish Times 2019
- "Áine Tyrrell's new album, Return To The Sea, is music for people who give a shit"- Mandy Nolan, The Echo 2019
- "Her voice is unmistakably Irish, in a way few singers are any more." Irish Echo 2016
- "Soul, intelligence, wit and wisdom, history and mystery and a voice that brings it all together. Don't miss her, for fear that you might miss the very thing you need." – Shane Howard
- "She has music in her DNA. She has that rare ability to connect people through words and music." – Liam O'Maonlaí (Hot House Flowers)
- "Tyrrell's irrepressible personality and indefatigable nature pervades Queen of Swords" – Rhythms Magazine Jan 2016
- "Tyrrell's songwriting talent is evident in the crafting of the lyrics in this vigorous, barely tamed LP (Queen of Swords)." – BMA Magazine


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Sudipto is a Risk Professional with The Royal Bank of Scotland Plc. He conducts Risk Assessments and helps identify opportunities to improve the Control Environment. Prior to taking up this challenge, he has worked on Greenfield development on a variety of technology stacks and on large scale Transformation programmes in various capacities.
When he is not working, Sudipto can be found, either on a saddle, or out on field trips to increase his understanding of avian species while reconnecting with nature.
Why are you optimistic about the future of work?
only to satisfy my curiosity - to learn, to discover my limits, and to know how to improve


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Emmy Award Winning Product Designer (UX, UI, XD, ID) with over 18 yrs of exp. Startup/Design Advisor. Ex-Amazonian. San Francisco, CA
What you understand about any matter will be constrained ONLY by the questions that you ask. The words "why" and "how" have taken me many places. Definitely two of the most powerful words in my vocabulary.


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Actress Amanda Bynes has no doubt been on the media's radar with her court appearances and odd public behavior. Having been known for years to make an audience laugh with her comedic roles in films such as, "Easy A" and "She's The Man", fans and admirers laughs have turned to quick concern for the talented star. But whether people think Amanda Bynes mental illnesses are a forever diagnoses should think again, it could actually mean a good thing.
In early 2012, Bynes started hitting headlines after arrests were made for D.U.I's and hit and runs. After being arrested again for possession of marijuana, Bynes was then caught attempting to start a fire in a stranger's driveway. This lead to an involuntary stay in a psych ward where she received a diagnosis of schizophrenia.
How did this funny woman suddenly change so dramatically in the course of her young career?
Sources report that the star has been suffering from post-traumatic stress disorder due to the pressures of celebrity which started in childhood. Her career on popular Nickelodeon television shows like "The Amanda Show" may have played a role in her current struggles. It's no surprise the kind of impact the lifestyles of the rich and famous can have on an individual. We all recall Drew Barrymore's wild child ways, Britney Spears' meltdown, and the current struggles of Lindsay Lohan.
But new studies leave hope in the case of Amanda Bynes' mental illnesses developing into what could be a good thing for the star. While schizophrenia can be exceptionally difficult to treat, it's not a forever psychosis. That's at least according to the book, "Rethinking Madness: Towards a Paradigm Shift In Our Understanding and Treatment of Psychosis," by author Paris Williams. In it, he notes that it is possible to recover from schizophrenia.
He analyzed six recovered schizophrenics in the book and it was found that their psychosis was brought on by significantly difficult childhoods. Also a factor? Their use of recreational drugs prior to psychosis.
Although these recovered schizophrenics have indeed healed and grown from their experiences, they do go on to note that the care they received may have hindered their overall healing process. The psychiatric system was, in their opinion, not well equipped to deal with their psychosis. They felt unsupported emotionally and harm from the anti-psychotics given to them.
"We've discovered that those diagnosed in the United States and other "developed" nations are much less likely to recover than those in the poorest countries in the world," says Paris Williams.
How can this be? Well, Paris Williams believes mental illnesses serve a purpose. When our minds are trying to process and comprehend difficult emotions and experiences, it is trying to adapt to a new way of coping, thus leading one back to normality. But when our psychiatric system introduces the use of antipsychotics, this hinders the natural healing process. Nonetheless, the six recovered schizophrenics note that they came out of their psychosis much stronger, with an overall new perspective.
Whatever speculation surrounding Amanda Bynes' history and troubled past, we need to allow the space, room and understanding for her to heal and benefit from this mental illness experience and in return emerge as the healthy, talented, comical woman we have all come to know.
Written by Annie Elizabeth Martin
Source 1


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Study of BSE 200 firms finds only 7 of 80 new appointments from promoter family
The Securities and Exchange Board of India's directive to listed companies for at least one woman on their board of directors has seen different responses from the top rung and the herd.
A majority of listed companies have appointed family members to fulfil the directive. However, the top 200 companies listed on the BSE report a happier trend.
Of these, as many as 96 already had at least one woman on their board. Another 80 companies made fresh appointments since Sebi's directive in February last year. And, of these 80 appointments, only seven are from the promoter family.
More interesting, of the 80 new appointments, 51 women are becoming a director on a board for the first time, with only five from the promoter family.
Which shows these companies seem to have done a thorough exercise to seek professionals of calibre.
"Large companies would usually be more conscious of their image and even if women family members are in a position to contribute on the board, perhaps they would not want that situation, and look for independent professional women directors," says Ketan Dalal, managing partner (west) at PwC.
The list of first-timers include former member of the International Finance Corporation management group, Farida Khambata, who has joined the board of Kotak Mahindra Bank. And, business historian Gita Piramal, who has joined the board of Bajaj Auto.
A study by Delhi-based financial services firm, Prime Database showed a different trend when it tracked 1,478 companies listed on the National Stock Exchange.
There were 987 companies who did not have a woman director when Sebi announced its directive last year.
And, 674 have complied since then -- a majority of the appointments being from the promoter family.
"Large companies have a greater presence of institutional investors.
"Hence, their corporate governance requirements are more stringent and it shows investor push in selecting valuable candidates," says Pranav Haldia, managing director at Prime Database.
However, there is also another other side of the coin, one which makes many women hesitant to join smaller companies.
The new Companies Act has made the duties and liabilities of the director much more stringent.
Hence, woman professionals are also more cautious in their selection, with a preference for large companies, with robust practices, for corporate governance.
"From the perspective of women directors, it is understandable why they are more selective in joining companies," says Amit Tandon, co-founder at proxy advisory firm Institutional Investor Advisory Services.
"They need the comfort, especially when joining a company's board for the first time and large, well-governed companies offer this," he adds.
The image is used for representational purpose only
Photograph: Reuters


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Microtate-o-waveFebruary 22, 2010 at 5:34 AM | Posted in Brain Crack | Leave a comment
They should make microwaves that don't stop rotating until your mug handle is facing towards the door.
It's simple. There's already a mechanism that does nothing but rotate things. All you have to do is set it up so that it remembers its initial position, and then when you open the door, it rotates back to that position. Assuming quite naturally that you put anything with a handle into the microwave with the handle facing towards you, it's now facing towards you again. This way, you don't have to reach around a hot mug to rotate the handle while trying not to burn yourself.
Also, there should be a different colored light when you open the door, because the light when the oven is turned on is subliminally linked to "deadly radiation."
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text: This large apartment of about 160 m² is situated on the 7th and last floor of a well-kept property, only 600 meters from the Mediterranean Sea and its beaches, east of Antibes' city centre and within immediate proximity to shops, bakeries and restaurants. The apartment consists of a large living room, a spacious dining room in connection to the kitchen, all of them with direct access to a corner terrace. There is a large master bedroom of 33 m² with en-suite bathroom and toilet and two further bedrooms sharing a bathroom with toilet, an office, a spacious entrance hall as well as a guest toilet. Air conditioning throughout. The terrace of approximately 60 m² lounges each side and offers splendid views over the sea from Nice and the mountains in the East, to Cap d'Antibes in the West and further across the rooftops of Antibes. There is a storage room, an outdoor parking area and a garage in the basement. A roomy apartment in need of some refurbishment, from which you can enjoy really unique views.


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Hotel Red House inin
The type of Hotel "Red House" is a guest-house. The advantages of the hotel is that it is a new hotel and located in the prestigious area, just 50 meters from the skiing route of Bakuriani. Hotel distinguished with fashionable and wonderful interior design and warm family atmosphere. The management of the hotel takes care that tourists will get a great pleasure after the rest in the hotel. Hotel Red House involves eight rooms comfortably furnished.
The popular skiing resort Bakuriani is located in the southern part of Georgia, in district of Borjomi . It is located on the northern slope of the Trialeti Range, at an elevation of 1,700 meters (5,576 feet) above sea level.Bakuriani is surrounded by coniferous forests.
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24 May 2019
How I Manage My Mental Health
If you've been here for a while, you'll know that I struggle with my mental health and battle anxiety and depression on a daily basis. As a result, I feel like I've developed a few strategies that help me to keep my mental health in a good place. Obviously, I still have days and weeks where my depression can hit me like a truck and I just have to ride it out until it gets better, but in general I feel like I've got my mental health 'under control' so wanted to share a few tips I've found along the way.
Be kind to yourselfThis is so much easier said than done, but I often find we're so much more critical of ourselves than we would ever dream of being to someone else! It's okay to skip the gym one day, to stay in bed watching Netflix, or eat an entire pack of Jaffa cakes to yourself (or doing all three at once if you're me) because doing, or not doing, those things does not make you any less valid as a person. As long as you're trying the best you can in your current situation then you should be proud of yourself regardless of what anyone else thinks.
Learn to disconnectI'm going to go into this in more detail in a separate post, but I think it's so important to take a break from social media and the internet in general when you're not in a good mental place. It can often be overwhelming spending so much time scrolling past other people's lives and all the exciting stuff they're getting up to when you're in bed at 2pm trying to muster the energy to take a shower. We've been conditioned into believing the 'best' shots of people's lives we see on Instagram is what their life is like 24/7, but this is definitely not the case - it's important to remind ourselves that we only see the bits that people want us to see, but *shock* everyone else is just a normal person like us who has crap days.
Find an exercise you enjoy
If you'd have told me six months ago that I'd be the kind of person who went to the gym at least twice a week I'd have said you're mad. When I was in the peak of my depression, even the idea of going out and being physical active was a big no no, but there came a point where I forced myself to do so and it made such a difference. Signing up for a gym and knowing that I'm paying a set amount each month regardless of if I actually go is what motivates me to go at least twice a week because I want to get my money's worth (because I'm a cheap skate) For me the gym works really well because being in a social setting also helps to boost my mood, but the actual type of exercise you choose doesn't really matter as long as you enjoy it and get those sweet sweet endorphins.
Make the effort to socialise
This is probably one of the things I struggle with most, as I'm a very introverted person, but spending time in the company of other people is such a mood booster! Obviously my first choice would be spending time with family and friends, but if that's not an option one of my favourite things to is head to a coffee shop to grab a drink and do some work. This way you still get the benefits of being in the company of other people without having to actually socialise (does that make sense?)
Those are my main tips in maintaining a good mental health. Let me know what you do if you're having a bit of a crap day to cheer yourself up, because I'd love to have a few more ideas for when I really need them!
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