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Arrived today
MARKS&SPENCER reviews
Margaret Cox Published todayI came into Colchester store to order a pair of track suit bottoms the lady downstairs tried her best to help me but unfortunately her phone kept losing the signal. I went upstairs to try there and was helped by a nice lady called Maria, so managed to get sorted.Expand reviews
Kath Shooter Published this monthBought a beautiful set of dining table and chairs called Sonoma. Delivered this week by two very courteous and helpful delivery men. Absolutely thrilled with our purchase as they look great .Expand reviews
RENO Published this monthMarks and Spencer are the best superb quality and presentation... cakes to die for ... every store we have shopped in keeps up with the M&S standardsExpand reviews
Sean Mc Published this monthWent into M&S Food on Sunday with two giftcards. Two things stood out about the customer service. 1) the man at the bakery counter offering to get us the freshly baked bread that wasn't out yet and talking us through the options. 2) the checkout assistant who helped us with the awkward voucher codes even though the manned checkouts were closed until 10am. Really good service and a great selection of food and drinks.Expand reviews
Richard Published this monthAlways Loved Marks & Spencer Great quality clothes & homewares, nice selection online, but I prefer the store where I can properly see the product. Never bought a bad product. Love buying birthday & Christmas gifts here & treats for myself. I love the M&S Food Hall here too. Majority of staff are friendly.Expand reviews
Reduced Marks & Spencer's Food Haul 🌈 / Sam Bakeer
Hi there welcome to my channel it's Sam Bakeer here I have lots of savings with all these lots I bought from Marks& Spencer's Very good quality and very good ...Published this week


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As your adventure overseas draws closer and you need to travel back home, you will need to fill out a customs form for declaration, which is the very first step in finishing your Border and Customs protection secret number interview and inspection with the customs official. (If you intend driving pass any international border, you won't be required to fill the form, however, you will need to inform a customs official about what you had purchased while you have been away from the country.)
On arriving at any international border or passport control, a border and customs protection official will need to review your personal declaration form, check out your passport and as well as ask you certain questions about your trip and the products or items you are bringing back.
If you make or have plans in advance, you will help make inspection process by customs officials go smoothly. Below are certain tips for clearing customs quickly.
#1: Make a packing list
The very first step in knowing which items or products to declare is by creating a packing list of all those items you had brought from home with you. This list will not only assist you in organizing your suitcase as you begin your trip, but it will as well be very helpful when the time for filling out your customs forms comes.
#2: Understand the rules
Every country has its own different customs rules and regulations. Make out time to read through these rules before beginning your trip so that you can know the items you can and cannot bring back. The U.S, United Kingdom, and Canada governments, for instance, all give out customs information regarding travelers on their various websites.
#3: Register high-value items
You can also register high-quality products or items, like laptops, cameras, watches, and computers, with the customs agency in your country prior to your traveling date. Following this step will be helpful in providing border and customs protection officials with proof that these items are owned by you, thus saving you trouble and time whenever you return back home.
#4: Save Receipts
Bring along a plastic zip-top bag or an envelope with you for storing receipt. Whenever you purchase something when you travel, properly tuck these receipts into the bag or envelope. When the time finally arrives for filling out your customs declaration form, you will possess a physical record regarding all your purchased items and products.
For a safer and faster importation of your products, you can consider using such reliable brokers like the Clearit USA customs clearance brokers for the best importation experience.

subset: commoncrawl


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Jul 24, 2018
Facebook angers Flanders with Rubens ban
The Flanders Tourist Board has written an open letter protesting against Facebook's "Cultural censorship" of adverts showing paintings by Flemish painter Peter Paul Rubens. The letter to Facebook founder Mark Zuckerberg was signed by the chief executive of Visit Flanders, Peter de Wildes, and supported by a network of museums and cultural institutions. "After all, we want to use your platform to promote both our Flemish masters as well as Flanders - because art lovers use Facebook too." "If Peter Paul Rubens had created a Facebook account in his lifetime, he would have had an extraordinary number of people following his fan page." Poking fun at Facebook, the tourist board also posted a satirical video on YouTube showing tourists at the Rubens House, in Antwerp, being ushered away from paintings featuring nudity.
Related companies
Make a complaint about Facebook by viewing their customer service contacts.


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The Grazing Goat
Top tags:
Enjoy a local ale, a creative cocktail or our daily market fish special in the comfort of the Ground Floor Bar, surrounded by open fireplaces, wooden panelling and large French doors.
The Grazing Goat has eight beautiful rooms set over three floors. Each room boasts modern country house styled interiors, en-suite bathrooms, complimentary Wi-Fi and Aesop products. The rooms offer a tranquil escape from a busy London lifestyle.
1,000-Point Tables
See availability for 1,000 point tables
Mon - Wed 12:00PM - 10:00PM
Great service and the food was amazing!
Went for Sunday roast and was lovely!
Fantastic doggie friendly place with great food and upmarket ambience.
Food and service are always great. Good place for a quick drink or a lazy Sunday brunch!
Very good food. Service wasn't amazing but what would be expected from a busy pub.
Cedric, our waiter, was awesome. Very accommodating for a family with two babies and a big pram. Excellent food, loved the specials.
Very good and casual atmosphere
Was in London for work and was staying in the area. I ended up having dinner 3 times at the Grazing Goat. Once by myself, 2 other with colleagues. We all had fantastic meals and drinks.
Amazing Beef Wellington!
Lovely place. Excellent pie. Smoked salmon starter could have done with some butter or different bread (bit dry).
A friend recommended this place and it was phenomenal- British food has improved drastically for sure.
I had the Venison and a salad and my team mates had the same plus salads. Great wine list and we sat upstairs at a large round table.
The only odd thing was that our Open table reservation did not show up in the restaurants reservations listing.
However, they were very gracious and found us a nice table for a lovel meal.
Had a lovely lunch for 7 on sat night. Were given a big round table the restaurant which was great. The place was buzzing but not too noisy. Food was great with two good veggie options. In fact most of us had either the mushroom burger or the roast butternut- even the meat eaters! The only downside was one of our party got their main as everyone else was finishing, but it didnt spoil things as the food was good and they offered is a free glass of wine. None of us had been there before and we all agreed we would go back!
Family reunion. Great time. Thanks!
Perfect place for a delicious meal.
Amazing atmosphere! We have been to this place last weekend for friends' gathering; spent 5 hours...
Food was very good, staff was really helpful and efficient.
Will definitely go back there!
We had booked very early, 5:15, as we went with our young son hence it was indeed very quiet as we were the first in the upstairs dining room, though the downstairs was very vibrant already. This was the third time we have eaten at the Grazing Goat and the food was, again, excellent; it is interesting and imaginative without being fussy or clever for the sake of it. The venison was sublime and perfectly cooked and presented, as was my wife's hake. Much thought goes into providing a complementary range of tastes on each of the mains; dessert should not be missed. There is an excellent range of wines with some more premium wines available by the glass via the Coravin system -- these are well worth trying. The staff are always friendly, informal and carefully attentive, and the child's menu was excellent quality with its portion size perfect. We will return!
Amazing apple pie!
Lovely atmosphere and friendly staff :)
Delicious roast dinner. Wine was great and barman downstairs was knowledgable and made a great recommendation. I will definitely return!
The venison was outstanding. Excellent service and great ambiance.
I booked this as it came up on google maps as an in between place to meet. We had a really lovely meal. The food was excellent and the staff really friendly. Although the website said we could only have the table for 2 hours we definitely had it for longer. I would definitely recommend and return.
Lovely Sunday roast with a nice ambiance.
Beautiful food, excellent staff and service, will definitely go back again! Can highly recommend!
It was incredibly hot inside and service was slow.
Had Sunday lunch there with two friends before going to BST in Hyde Park. Excellent welcome from staff. The starters (we had two to share between four of us) were excellent - probably the best squid I've had!! The main courses were plentiful and well cooked. However, my friend asked for her venison to be pink and it arrived very grey - mine was just right and pink. Table service was a bit on the slow side and it took a while to attract attention. We ordered a bottle and then a carafe of Malbec (as usual) only to discover that the wine in the carafe had a tremendous amount of sediment in the bottom which was not good. When we got the bill the price of the carafe was removed without any problem. However, when the revised bill was delivered we were given what could only be described as a 'lecture' on Argentinian Malbec and that this was normal. I beg to differ, particularly when the initial bottle we had was fine. It just left a sour note at the end of our visit. Overall though it was a good lunch and I would recommend others to go there as long as they stay clear of the Malbec!
We had the mushroom burger with cashew sauce and was excellent veggie option. Also the truffle fries are an absolute winner.
Fathers Day Sunday Roast SUPREME
Very tasty, well-prepared food in a pub with nice atmosphere (buzzy, but not too noisy). The service was excellent - the manager and every member of staff were friendly and helpful. We had a group of 6 that spanned from 10 to 60 years of age. All were happy with the various starters and mains we ordered off the a la carte menu and would be happy to go again.
The food was very ordinary. Uncomfortable seating and it was draughty and cold where we were sitting
Another great meal at the grazing goat. Perfect unobtrusive servive, and delicous food.
A luke warm lamb pie with a few undercooked onions and green beans for £16.00!
The hamburger which was supposed to be medium rare came out the first time between raw and rare. The lamb pie had very few vegetables and very little lamb. The lamb was outnumbered by the fat. Service was good and attentive.
Service was lacking despite the restaurant being half empty.
Gastropub menu. Had the homemade chicken pie which was delicious. Service is quick and efficient. Was surprisingly quiet for lunchtime - has been much busier when I'd visited previously.
The house pie was fantastic and the service was superb! We loved the energy at the restaurant and it's definitely a local favorite.
Friendly professional staff serving excellent food and drinks
Great food
Friendly helpful service
Will definitely go again
Wonderful ambience, ate early upstairs so quieter, staff was terrific, hake dish with asparagus and peas excellent
The food was delicious but unfortunately it was really let down by the service. We had to approach the team members to ask for things every time including menus.
Booked this restaurant for a family birthday meal. It is perfectly located in central London. The dining room upstairs was a perfect blend of warmth and charm. The staff were very attentive and relaxed. Great not to be rushed. The food matches the ambience and everything we ate was delicious. Would highly recommend.
The Grazing Goat is rated 4.5 stars by 1279 OpenTable diners.
You can book this restaurant by choosing the date, time and party size.


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Michelle Obama Hilariously Breaks Down Why Melania Trump's Inauguration Gift Exchange Appeared So Awkward
The former FLOTUS also explained to Ellen Degeneres how Barack stepped in and saved the day.
When it comes to their relationship, Jay-Z and Beyoncé have been pretty hush hush over the years. But recently the two megastars have both discussed their admiration for the other's talent. In a radio interview with Philadelphia's Power 99FM (via Sohh.com), Jay-Z went so far as to compare his beloved wife to the king of pop, Michael Jackson.
"I know that's blasphemy to compare the two because Mike was such an innovator," said Jay, "but I think she's like the second coming." Jay went on to explain his statement, speaking specifically of Beyoncé's work ethic. "You know, the hard work and dedication that she puts into her shows. It just makes you want to work harder at your own craft. She's like a machine."
Last month on The View, Beyoncé referred to herself as a "Jay-Z groupie," saying she was inspired after watching her husband's shows from the audience.
(Photo: Kevin Mazur/Getty Images)
The former FLOTUS also explained to Ellen Degeneres how Barack stepped in and saved the day.
"When my teacher asks me a question thinking I'm not paying attention, but I get it right."


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In this week's Groove pack is the Four Leafed Clover in Moth headgear, a cute gear that fits with the St. Patrick's day theme, but as we found had no effects. As a forum event I wanted to have the community get a crack at designing a fun effect for this headgear that isn't involving green ales.
Post the winning suggestion and get a free named 4 leaf clover in mouth!
It will have LUK+3 at the very least.
Contest ends Monday March 17th


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The Michigan Journal of Public Affairs (MJPA) accepts exceptional, original, and rigorously researched academic papers, articles, and Op-eds, on any public policy related-issue for our Volume 16 edition. We encourage submissions to include thorough analysis and/or policy recommendations. Submissions for MJPA Volume 16 are now closed. We will open submissions for MJPA Volume 17 in the fall of 2019.
Submission Guidelines:
- Eligibility: We accept submissions from graduate and professional students, academics, and professionals working in policy-related fields
- Citations: Must be included and formatted to Chicago Style and include endnotes
- Originality: Pieces should not have been previously published on any platform
- Email submissions to email@example.com
- Email subject line should be in this format: Last name, First Initial-Volume 16 (Article/Note/Special Issue)
- Include your name, institution and title of your paper in the email. Do NOT include your name in the actual paper
- Attach your paper as a .DOC, .DOCX, or .WPD, complete with citations, to the email
In addition to our Volume 16 submissions, MJPA is also accepts articles and Op-eds on a rolling basis for our online platform. See Online Submission Criteria for more information.
For more information, please contact email@example.com


text: Individually hand-torched, each piece is completely unique due to the random formation of colors during treatment. A material prized in both aviation and Formula One, Grade 5 Titanium is 2.5 times stronger than stainless steel but only half its weight, allowing the Advent to feel impossibly light yet reliably strong. Completing the Advent is a protective TPE housing that serves as a layer of shock absorbance between the Advent and the iPhone. The housing allows the Advent to grip onto the iPhone through a friction fit, ensuring an elegant installation experience. Limited to only 100 pieces worldwide, the unique serial number of each Advent is laser engraved onto the case as a reminder of its exclusivity. Furthermore, a special place on the Advent is reserved for your name to be engraved.


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Text by Terri Chen
TRENDS – 'The designer is always our starting point in product development,' says Arno Beurskens of Vescom, an international brand of high-end interior products for the contract market. Over the past month, Frame has been following the design, development, production, and supply processes of the company's wallcoverings and upholstery and curtain fabrics.
With a flexible production model, Vescom produces in direct response to requirements by designers and architects. 'Where other manufacturers go for the industrial model, we focus on the customer's model,' says Beurskens. Vescom has 16 sales offices around the world as well as dedicated distributors in 80 countries, tasked with identifying projects that might require Vescom products.
This global network of locally based representatives allows Vescom to guarantee short lead times as well as personalized and accountable customer service.
Vescom's Greenbo wallcovering takes organic forms inspired by nature
At the same time, Vescom is a manufacturer with an international presence, which puts the company in a position to consider the big picture. Environmental sustainability is a priority for the forward-thinking brand, which has proven to be ahead of legislation when it comes to responsible manufacturing practices. 'We were the first manufacturer to start water-based printing almost 30 years ago, long before there were laws regulating the use of solvents,' says Beurskens. 'Today, we even recycle the water that we use in production!'
Vescom's manufacturing facilities in the Netherlands and the USA also serve as production hubs for the two regions, allowing Vescom to reduce its transportation costs. '70% of our business comes from Europe and North America,' says Beurskens, which means that effectively, Vescom is a predominantly local or regional producer.
However, Vescom's most significant contribution to environmental sustainability is a feature of the products themselves. 'All our products have a very long lifespan, especially the vinyl wallcoverings,' says Beurskens. 'In terms of business, it's both an advantage and a disadvantage, but we have ample instances of projects where our wallcoverings have been in use for 20 years.'
Schools and colleges, occupied by hundreds and thousands of students every day, benefit from Vescom wallcoverings, upholstery and curtain fabrics that can stand up to heavy use year after year
This longevity also makes Vescom products an asset to cash-strapped institutions such as healthcare centres and hospitals, which are often government-owned. 'Vescom products are in use in many West-European hospitals for the simple reason that they're easy to clean and don't change appearance, even after 25 years,' says Beurskens. 'By contrast, if you use fibreglass and paint, it's difficult to clean so you have to paint it again and again, year after year.'
Compared to the alternatives, Vescom wallcoverings may be a larger initial cost, but they make long-term economic sense and can add softness and warmth to the often stark and clinical atmosphere of healthcare institutions.
Zaans Medisch Centrum, a healthcare centre in the Netherlands, covered the walls of their lounge and waiting area with Vescom custom-printed vinyl. Photo by Silo Agency
There has been a shift in recent years towards creating a sense of welcome and hospitality in spaces for healthcare, work, learning, and retail. Vescom design director Christiane Müller believes that design innovation requires being sensitive to these changing needs and new information from the market. 'We have to be aware not just of how spaces change, but also how the uses of spaces change,' she says.
'The form and function of the products are therefore not separate, but merged together in the design. Sometimes a product may be more focused on a solution, like a walltalker serving as a writable surface – but we have a lot of products that do both,' says Müller.
The Just-Rite walltalker allows employees to literally write on the wall. The vinyl surface is dry-erasable
Innovation also can be very technical, such as the acoustic curtains Vescom developed in response to open-plan workspaces. This represents innovation from both directions of product design, as the manufacturer is informed by market needs and trends.
Acoustic curtain Carmen improve the acoustical value of a room
Close-up of Formoza, a transparent curtain that provides sound absorption of 0.8 alphaw while maintaining a sense of spaciousness
Further emphasizing the brand's customer-focused approach are Vescom's digitally printed wallcoverings. Merging product and service, Vescom offers a database of 125 million images to suit any hospitality, workspace, retail, education, or healthcare interior, and customers may also supply their own designs.
From ideation to conceptualization to production, the specialists at Vescom work with customers to design and customize the digitally printed wallcoverings, with a choice of seven different surfaces, for a truly unique statement interior. Utilizing the latest technology, Vescom guarantees a seamlessly printed image from floor to ceiling up to 3.15-m high and 30-m wide on its langor+print. They truly take the customer-first approach in every aspect of the company.
Frame visited the Vescom office for a behind-the-scenes tour of the production facility where the wallcoverings, upholstery and curtain fabrics are made.
'Form and function go hand in hand,' says Christiane Müller, as she explains the creative process which begins long before the embossing rollers roll.
Arno Beurskens and Christiane Müller discuss how Vescom's worldwide presence facilitates open communication with customers on their design needs.
Joop van Esch founded Vescom in Deurne, the Netherlands, in 1971. The company is now headed by Joop's son, Philippe, who took the reins when his father retired in the early 1990s.


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one thing i try to do when i am home is spend as much time with my closest friends as possible. sometimes i feel like i am always making the rounds but i'm usually not home for very long so i have to take advantage of the time that i have.
last month when i was home i spent some time with my oldest friend, jess. we spent most of the time looking at her inspiration pictures for her upcoming wedding! i was so excited when she got engaged a few months ago and all i have wanted to do is talk to her about what her big day is going to be like.
while we were being super girly looking at wedding pictures, she asked me to be one of her bridesmaids! she had made all of her bridesmaids their own nail polish color in a box asking for us to pretty please be her bridesmaid? of course i said yes!
so now that my brother's wedding is done i have another one to look forward to next year!
i can't wait to spend this next year helping you get ready for your big day.
love you, jess!


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Header install location fix; components for win32
The 1.0.0 release binary packages were installing headers in the wrong place (include/common.hpp, etc. instead of include/fracdist/common.hpp), and were missing the fracdist/data.hpp header. Added component configurations for Windows installers so that Windows users can elect to not install the headers and/or docs when using the .exe installer.
parent 4c972e39
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CHANGELOG.md 0 → 100644


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Download your eBook
There's no such thing as a one-size-fits-all platform when it comes to analytics.
In the 20th century, the key business intelligence challenge we faced was a shortage of useful empirical data. In the 21st, the issue is having so much it's hard to know where to start looking. Companies with adequate resources and institutional willpower can throw considerable sums towards establishing advanced-analytics programs.
The issue becomes what to do with all of the information being gathered. And that's why we wrote this guide to finding the right analytics platform.
In recent years, McKinsey Analytics has conducted extensive research on companies making big investments in advanced-analytics tools. They found that as little as 10% of the potential value these approaches unlock has been realized by the lion's share of investors. One recurring issue is a consistent failure to tie these technologies to clear, actionable business goals.
In this guide, we'll explore what kinds of data are most relevant to common business problems. We'll then look at key features offered by various analytics platforms that can help you solve them.


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The Gut Microbiota and Immune System Relationship in Human Graft-versus-Host Disease
Lucrezia Laterza1, Gianenrico Rizzatti1, Eleonora Gaetani1, Patrizia Chiusolo2 and Antonio Gasbarrini1
1 Fondazione
Policlinico A. Gemelli,
UOC of Internal Medicine, Gastroenterology and Liver Diseases.
L.go Gemelli, 8 Rome, Italy
2 Fondazione Policlinico A. Gemelli, Institute of Haematology, L.go Gemelli, 8 Rome, Italy
Received: February 22, 2016
Accepted: April 10, 2016
Mediterr J Hematol Infect Dis 2016, 8(1): e2016025, DOI 10.4084/MJHID.2016.025
This article is available on PDF format at:
| This is an Open Access article distributed
under the terms of the Creative Commons Attribution License
(https://creativecommons.org/licenses/by-nc/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Gut microbiota has gained increasing interest in the pathogenesis of immune-related diseases. In this context, graft-versus-host disease is a condition characterized by an immune response which frequently complicates and limits the outcomes of hematopoietic stem cell transplantations. Past studies, carried mostly in animals, already supported a relationship between gut microbiota and graft-versus-host disease. However, the possible mechanisms underlying this connection remain elusory. Moreover, strategies to prevent graft-versus-host disease are of great interest as well as the potential role of gut microbiota modulation. We reviewed the role of gut microbiota in the development of immune system and its involvement in the graft-versus-host disease, focusing on data available on humans.
Microbiota is the complex system of bacteria, archaea, viruses and
fungi living in several body niches, such as skin, vagina, nose and
mouth. However, the majority of microorganisms live in the digestive
tract. Gut microbiota should be considered a real organ, accounting 100
times more genes than the host and being responsible for multiple
functions and in particular of the metabolic and immune homeostasis.[1]
Recent studies demonstrated that gut microbiota is only the first layer of a multilayer barrier separating our organism from the content of intestinal lumen and, thus, from the external environment: the so-called "gut barrier". This barrier is composed, beyond microbiota, by the mucus layer on the epithelial cells, the epithelial cells themselves, the immune cells harboring in the submucosa and by the bidirectional interactions between all these layers (Figure 1). Its integrity is essential to maintain the homeostasis, and its disruption has been associated with many gastrointestinal and extragastrointestinal diseases. Whereas the role of gut barrier disruption appears clear in gastrointestinal disorders, its role in extragastrointestinal diseases could be harder to understand. The basis of this role should be searched in the complex function of immune stimulation/tolerance that gut microbiota exerts.
|Figure 1. The gut barrier and its alterations during the pathogenesis of GVHD. The healthy gut barrier is essential to maintain the immune homeostasis. Total body irradiation and/or chemotherapy, used as conditioning regimen, lead to gut barrier disruption, damaging the mucus layer and the epithelium. Thus, bacteria and bacterial products such as lipopolysaccharide translocate in the lamina propria where, together with endogenous danger molecules released from damaged epithelial cells, activate host and/or donor antigen-presenting cells (APCs) which prime alloreactive donor-derived T cells, triggering the damage to target organs. Modified from Heidegger.[59]
Hematopoietic stem cell transplantation (HSCT) is a
potentially curative therapy for many diseases, mostly hematological,
otherwise associated with a poor prognosis. Unfortunately, the
widespread use of this treatment is often restricted by the development
of graft-versus-host disease (GVHD) a condition in which
immunocompetent donor T cells attack host tissues in immunocompromised
patients, constituting one of the leading causes of non-relapse
mortality.[2] GVHD depends on several factors, such as
age, conditioning regimen, hematopoietic graft source and prophylaxis.
The traditional classification of GVHD is based on the timing of onset:
acute (aGVHD), within the first 100 days after HSCT, and chronic
(cGVHD), after the first 100 days. However, beyond the temporal
criterion, aGVHD and cGVHD are different diseases, with characteristic
clinical presentation, diagnostic criteria, and tissue pathology.
Systemic inflammation and tissue disruption predominate in aGVHD,
whereas the immune dysregulation leading to several infections is the
prevalent presentation in cGVHD.[3] Thus, the
characteristic clinical manifestations became the diagnostic features
instead of the time of the onset, based on National Institutes of
Health (NIH) consensus criteria.[4]
In particular, in this review we discuss the role of gut microbiota in the GVHD, focusing on data on humans.
The Healthy Gut Microbiota
In the last years, the increasing interest on human gut microbiota
led to large-scale attempts to characterize it. The association of
traditional cultural techniques with new molecular techniques based on
the analysis of the small subunit ribosomal RNA (SSU rRNA) gene
sequences as phylogenetic markers made bacteria the most known
components of gut microbiota, identifying more than 1000 species.
Bacteria together with Archaea and Eukaryota constitute the three
kingdoms in which life is classified. Bacteria are subclassified in
many phyla (plural of phylum, major taxonomic division that contains
one or more classes, Box 1),
but only a few phyla are mostly represented, accounting for more than
160 species, and, among them, Firmicutes (consisting mainly of
Gram-positive clostridia) and Bacteroidetes (consisting mainly of
Gram-negative bacteria) are prevalent.[1,5]
These two phyla, together with the less represented Actinobacteria and
Proteobacteria are not only the most abundant, but also include
the most diverse microorganisms in
the adult gastrointestinal tract. Other represented phyla
are Verrucomicrobia, Lentisphaerae, Synergistetes, Planctomycetes,
Tenericutes and the Deinococcus-Thermus group, Melainabacteria, and
Gemmatimonacete. Regarding the other two kingdoms, the Euryarchaeota,
including the highly represented methanogens, are the most represented
Archaea, whereas, among the Eukarya, some Candida spp are the most
The earliest years of life are essential for the development of individual microbiota that depends on several factors, such as maternal and family members microbiota, kind of delivery, breastfeeding and early exposure to antibiotics. After this phase, individual microbiota composition is stable in the adult life for decades, and it may be the same also for the entire lifetime unless perturbing factors occur, such as antibiotic therapies or infections.[6]
|Box 1. Example of taxonomy of Escherichia coli.
The Role of Gut Microbiota in the Immune Regulation
The correct development of gut microbiota is strictly related to the
healthy maturation of the immune system, and both develop in the first
2 years of life. In fact gut microbiota constitutes a stimulus that
drives the development of the immune system in its capacity to react to
pathogens and in the induction and maintenance of the tolerance
process. On the other side, immune dysregulation can induce an
alteration in gut microbiota.[7,8] The importance of
this bidirectional relationship has been highlighted by data from
germ-free (GF) animals that showed reduced development of both innate
and adaptive immunity with increased susceptibility to microbial
The integrity of the gut barrier is the basis of the healthy stimulation of the immune system by microbiota.
In fact, the continuous stimulation by luminal commensal antigens should be regulated to avoid the over-stimulation of the immune system. This is warranted by the presence of a physical barrier between gut microbiota and host immune cells, composed of epithelial cells and the mucus layer above them. In particular, the mucus layer consists of an inner and an outer layer, but whereas the outer one is colonized by large numbers of bacteria, the inner one, thicker than the outer one, constitutes a barrier for them.[11,12] Furthermore, even innate lymphoid cells[13,14] and IgAs[15] contribute to reduce the penetration of microorganisms through the epithelial cells and their presentation to the immune system. Microbiota is essential for the correct development of both innate and adaptive immune response.
Conversely, microbiota needs a healthy immune system to correct its development. In fact, for example, the deficit in IgA response alters the composition of microbiota.[16-18]
Microbiota and the Innate Immune Response
microbiota could regulate lamina propria phagocytes and, in particular,
it could increase the production of pro-IL1β in resident macrophages[19] and neutrophils,[20]
that could be rapidly activated in IL1β in response to pathogens.
Microbiota could also influence systemic neutrophils response enhancing
their bactericidal activity triggering the NOD1 signaling through
peptidoglycan stimulation.
Microbiota and the Adaptive Immune Response
Data from germ-free (GF) animals demonstrated that when the microbiota is absent, there is a shift through a T-helper (Th)2 response, due to a reduced number of Th1 and Th17 cells, which could be reversible in case of colonization of the gut by flora. In particular, in the small intestine Th17 cells could be stimulated mainly by segmented filamentous bacteria (SFB), species belonging to commensal Clostridia-related bacteria,[21-24] and Lactobacillus johnsonii.[25]
Beyond T cells, also B cells and immunoglobulins production are influenced by microbiota. In fact, the intestinal mucosa is essential to the correct development of B cells as well as fetal liver and bone marrow, and microbiota is able to regulate intestine-specific B-cell receptor.[26,27] In fact, the presence of commensal microorganisms in the gut stimulates gut-associated lymphoid tissues (GALTs), such as both Peyer's patches and isolated lymphoid follicles.[28-30] The continuous stimulation induces germinal center formation in isolated lymphoid follicles and Peyer's patches and IgA production, differently from systemic lymphoid organs where germinal center formation does not occur under physiological condition, but only after a specific- i.e. infectious- stimulation.[31] In fact, microbial products are required to stimulate the germinal centers in lymphoid follicles and IgA production, in particular through Nucleotide-binding oligomerization domain-containing protein (NOD)1-mediated signaling.[18,32,33]
Tolerance Education by Microbiota
Colonic FoxP3+ T regulatory (Treg) cells are strongly influenced by the presence of gut microbiota. In fact, they are reduced in colonic lamina propria in the absence of gut microbiota stimulation, whereas the presence of gut microbiota is less relevant for Treg of the small intestine or mesenteric lymph nodes.[34,35] In particular, murine data demonstrated that Clostridia and Bacteroides fragilis could be the most powerful inducers of Treg,[34-39] probably working through different mechanisms which could be dependent and independent from toll-like receptors (TLRs) signaling. Among TLRs-independent pathways, short-chain fatty acids (SCFAs) - bacterial metabolites deriving from carbohydrates fermentation, including acetate, propionate, isobutyrate and butyrate- seem to be able to increase the acetylation of the Foxp3 locus, increasing the number of Treg directly or, indirectly, increasing the production of TGFβ in the intestinal epithelium.[36,40-42] Furthermore, SCFAs induced the expression of the receptor GPR15, responsible for recruitment of Treg in the large intestine.[40-50] Similarly, the folic acid produced by colonic microorganisms could increase the survival of Treg cells.[51] Furthermore, gut microbiota could stimulate the production of the anti-inflammatory cytokine IL10 by intestinal macrophages.[52]
The Allogenic Transplant and the Graft-versus-Host Disease
Every year, more than 39000[53]
HSCT are performed only in Europe for an ever expanding number of
neoplastic and non-neoplastic diseases, in particular for hematological
conditions such as leukemias and lymphomas.[54]
HSCT is still limited by the development of GVHD, a condition that
results from the interaction between the host cells which are targeted
by the transplanted donor immune cells, primarily T cells.[55]GVHD
was historically classified in acute and chronic, respectively, if the
onset of symptoms was before or after 100 days. However recent
advantages questioned these definitions, and current consensus states
that clinical features define GVHD as acute or chronic.[4]
occurs mainly in the skin, GI, and liver. GI manifestations of aGVHD
include secretory diarrhea, vomiting, abdominal pain and, in severe
cases, bleeding. The severity of aGVHD is classified in four grades on
the basis of the involvement of the organs mentioned above.[57]
On the other hand, cGVHD manifestations are typically variable, and
many organs can be involved, frequently with autoimmune-like diseases
GVHD Pathogenesis and the Role of Gut Microbiota
mechanisms leading to GVHD are usually divided into steps: organ
damage, priming of the immune response, activation of T cells and
destruction of target organs by mean of the activated immune cells[2,57,59] (Figure 1).
The incidence of GVHD is positively correlated with the degree of human
leucocyte antigen (HLA) mismatch as the histocompatibility antigens are
the main proteins recognized by donor immune cells.[60]
The connection between GVHD and microbiota was firstly suggested in
pioneering studies in mice.[61,62]
However, studies in humans are still scant and characterized by small
sample sizes. These studies mainly investigated variations in the
gastrointestinal microbiota before and after HSCT and the impact of its
composition on the transplant outcomes (Table
|Table 1. Summary of human studies assessing gastrointestinal microbiota in Graft versus Host Disease.
Taur et al. demonstrated that there is a marked reduction after HSCT in the microbiota diversity which leads to the selection of a limited number or, even, of a single "dominating" bacterial genus. Interestingly, patients who developed intestinal domination showed an increased risk of bacteremia which was frequently caused by the same identified "dominating" bacteria.[63] The authors also described the effects of different antibiotics on the development of specific bacterial prevalences: for example, fluoroquinolones reduced the risk of gram-negative bacteremia by decreasing proteobacterial domination.[63]
Given these data and considering the already mentioned dramatic impact of GVHD on survival, it is not surprising that microbiota diversity was also found to be an independent risk factor for mortality in patients undergoing HSCT.[66]
Consequent studies focused on the analysis of bacterial composition, researching if specific genera or species could be more implicated than others in the development of GVHD. For example, analysis of bacterial genera found that the abundance of a specific genus, namely Blautia (which belong to the Clostridia class), is associated with GVHD-related mortality.[67] Although it was not possible to demonstrate causality in this study, these data may represent a starting point for the development of a GVHD mortality biomarker in the near future.
Other studies investigated variations of the microbiota in relation to the development of GVHD, the second most common cause of mortality in the context of allogeneic HSCT.[64] In particular, the onset of GVHD seems to be associated with a progressive reduction of the microbiota diversity with a relative increase in Lactobacillales and a relative decrease in Clostridiales.[65] Noteworthy, these findings are consistent with those in mice, suggesting that animal studies may, at least, guide the research in humans.
other authors reported that there is an increase after HSCT in the
relative abundance of enterococci that was persistent and more
pronounced in adult patients with active GVHD.[68]
Similar results have been obtained in children by Biagi et al., who
analyzed fecal samples collected from 10 children before HSCT and three
times in the following 100 days. After HSCT, a profound alteration of
the gut ecosystem occurred in all children, with the loss of about 30%
in average of alpha diversity -a measure of diversity within a
population in terms of number and distribution- compared to pre-HSCT
samples. However, the last samples collected showed a minor degree of
difference compared to pre-HSCT specimens, suggesting a natural trend
to recover after the disturbance caused by the HSCT. The fecal amount
of short-chain fatty acids (SCFA) followed the variations of
microbiota: it decreased by 76% after HSCT, being propionate the most
reduced (mean loss 86%), and trend to recover distancing the HSCT.
Although these differences are common in patients with and without
aGVHD, the 5 children who developed aGVHD also showed an overgrowth of Enterococcus and Clostridiales and a corresponding
decrease of Faecalibacterium
and Ruminococcus. At phylum
level, patients with aGVHD showed a drop in Firmicutes
abundance after HSCT but, distancing the HSCT, they showed higher
abundance than the initial one, whereas they demonstrated a lower
abundance of Bacteroidetes
compared to non-aGVHD patients. Even if alterations of gut microbiota
induced by conditioning regimen and HSCT seem to be crucial to the
pathogenesis of GVHD, the pre-HSCT characteristics of gut microbiota
could also play a major role. In fact, children who developed aGVHD
showed lower diversity and richness before HSCT compared to the other
patients and, in particular, they demonstrated a lower abundance of Bacteroides and Parabacteroides, whose abundance
positively correlated with the concentration of propionate and SCFA.[56]
Our group identified that the conditioning regimen, starting from the same baseline microbiota composition, promotes changes in the microbiome, which are different between Autologous (auto-) and Allogeneic Stem Cell Transplantation (allo-SCT). After auto-SCT we documented an increase of Proteobacteria (Klebsiella, Proteus, Acinetobacter, Haemophilus, Pseudomonas, Enterobacteriaceae) and a reduction of Bacteroidetes (Bacteroides, Saprospirae, Prevotella). After allo-SCT, instead, there was an increase of Bacteroidetes and a reduction of Firmicutes (Bacilli, Lactobacilli, Clostridium, Enterococci, Streptococci). Moreover, patients who developed GVHD harbored more Firmicutes and Proteobacteria and fewer Bacteroidetes than patients without this complication. In patients with gut GVHD, Proteobacteria were more represented than in patients with liver or skin involvement.[69]
these studies showed that the intestinal microbiota is heavily affected
by HSCT, being the principal finding, reported in all studies, the
reduction in the overall bacterial diversity. At the same time, some
studies reported specific alterations which are interestingly
correlated with the development of the major complications of HSCT,
such as bacteremia and GVHD. While a causative role of the microbiota
in these conditions is yet to be demonstrated, these and future studies
may give a better comprehension of the complex mechanisms underlying
HSCT and GVHD, ultimately allowing better outcomes.
New Perspectives: the Role of Paneth Cells and Genetic Modifiers of Gut Microbiota
Recently, researchers focused on Paneth cells in an attempt to find a mechanistic relation between microbiota and GVHD. Paneth cells secrete antimicrobial peptides such as alpha-defensins which contribute to the regulation of the GI microbiota. During GVHD, Paneth cells appear to be damaged with a consequent reduction in alpha-defensins production.[70] Noteworthy, alpha-defensins activity is directed mostly toward non-commensal bacteria, thus decreased levels of these peptides lead to a reduction of commensal bacteria and, intuitively, to an impairment in their beneficial effects.
A subsequent study investigated if Paneth cells number may correlate with the severity, response to treatment and survival of GVHD. Authors found that Paneth cells number was inversely correlated with the clinical severity stage with a strong correlation between the two parameters. Response to treatment at 4 weeks was also found to be positively correlated with Paneth cells number, being highest in patients with a complete response and lowest in patients who did not respond. Finally, a threshold of 4 Paneth cells per high power field (HPF) was found to discriminate between high and low-risk patients regarding non-relapse mortality (NRM), with also a significant difference in the overall survival.[71]
Similarly, Ferrara et al. demonstrated that a specific lectin secreted by Paneth cells, namely regenerating islet-derived 3-alpha (REG3alpha), has diagnostic value in acute GI GVHD permitting to differentiate between GVHD-related diarrhea and other causes of diarrhea.[72] The authors also demonstrated a prognostic value of REG3alpha in GVHD, in particular, a positive correlation between plasma levels and NRM was found. This result may appear in contrast with the previous data, in particular with the evidence supporting a protective role of Paneth cells. However, the authors hypothesized that the GI mucosal barrier disruption which occurs in GVHD permits to the nearby Paneth cells secretions to enter the bloodstream.[72]
Similarly, there is an increasing interest in the role of the Fucosyltransferase 2 (FUT2) gene, a genetic modifier of the GI microbiota which seems to be associated with different GI diseases.
Various antigens are expressed in the intestinal mucin layer, for example, ABH antigens are oligosaccharides that constitute a site of attachment and a carbon source for intestinal bacteria.[73] Their expression is regulated by an enzyme which in humans is encoded by the FUT2 gene.[74] Polymorphisms in the FUT2 gene are correlated with alteration of the GI microbiota both in the compositional and functional level.[75] Recently, homozygosity for the loss-of-function alleles (non-secretors, A/A genotype) was demonstrated to be associated with increased susceptibility to Crohn's disease.[76] Rayes et al. also showed that FUT2 polymorphisms influence the risk of GVHD and bacteremia in the context of HSCT. Specifically, the Authors found that there was a reduced risk of acute GVHD with A/A genotype (non-secretors) and an increased risk with the G/G genotype (secretors) while an increased risk for bacteremia was found with A/A and A/G (secretors) genotypes.[73]
Gut Microbiota Modulation as a Preventive Strategy Against GVHD
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- Taur Y, Jenq RR, Perales MA, Littmann ER, Morjaria S, Ling L, No D, Gobourne A, Viale A, Dahi PB, Ponce DM, Barker JN, Giralt S, van den Brink M, Pamer EG. The effects of intestinal tract bacterial diversity on mortality following allogeneic hematopoietic stem cell transplantation. Blood 2014; 124: 1174-1182. http://dx.doi.org/10.1182/blood-2014-02-554725
- Jenq RR, Taur Y, Devlin SM, Ponce DM, Goldberg JD, Ahr KF, Littmann ER, Ling L, Gobourne AC, Miller LC, Docampo MD, Peled JU, Arpaia N, Cross JR, Peets TK, Lumish MA, Shono Y, Dudakov JA, Poeck H, Hanash AM, Barker JN, Perales MA, Giralt SA, Pamer EG, van den Brink MR. Intestinal Blautia Is Associated with Reduced Death from Graft-versus-Host Disease. Biology of blood and marrow transplantatio: journal of the American Society for Blood and Marrow Transplantation 2015; 21: 1373-1383. http://dx.doi.org/10.1016/j.bbmt.2015.04.016
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- Chiusolo P, Metafuni E, Paroni Sterbini F, Giammarco S, Masucci L, Leone G, Sica S. Gut Microbiome Changes after Stem Cell Transplantation. Blood 2015; 126: 1953
- Eriguchi Y, Takashima S, Oka H, Shimoji S, Nakamura K, Uryu H, Shimoda S, Iwasaki H, Shimono N, Ayabe T, Akashi K, Teshima T. Graft-versus-host disease disrupts intestinal microbial ecology by inhibiting Paneth cell production of alpha-defensins. Blood 2012; 120: 223-231. http://dx.doi.org/10.1182/blood-2011-12-401166
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therapiae experimentalis 2016. http://dx.doi.org/10.1007/s00005-016-0387-9


text:
OFF SAP generates interest
New Oracle Fusion for SAP (OFF SAP) offering attracts 230 SAP R/3 customers looking to move and run their businesses with an open, standards-based application solution.
Thirty days after Oracle introduced its Oracle Fusion for SAP (OFF SAP) programme, the number of SAP R/3 customers looking to make the switch to Oracle applications is growing. Faced with the challenge of re-licensing and re-implementing their applications in order to upgrade from R/3 to mySAP ERP or mySAP Business Suite, more than 230 companies have registered in Oracle OFF SAP programme and expressed their interest in migrating from legacy SAP to Oracle applications.
SAP customers show particular interest in leveraging the new Oracle programme to help save money, reduce complexity and improve the quality of business information by migrating to Oracle's open, standards-based applications.
Oracle's offer of up to a 100% license credit for SAP R/3 customers switching from SAP to Oracle applications is tempting many organisations, and the ease of migration is also a key concern for prospective customers.
Oracle Consulting has created an Insight for SAP migration programme to provide R/3 customers with a clear understanding of the migration process and its benefits, which include reduced upfront costs as a result of the two-year payment plan for the application license and support fees, with no interest and no payments for six months, followed by six instalments, available from Oracle Financing.
Oracle's information architecture will also allow customers to run one global model and instance, freeing R/3 customers from the challenge of accessing and integrating fragmented data from legacy systems based in ABAP language.


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27 million in U.S. at risk of losing health coverage amid pandemic
"We're seeing an unprecedented loss in jobs, and what's going to come along with that, is unfortunately the loss of health insurance as well," Kaiser Foundation Executive Vice President Larry Levitt said.cbsnews.com
Colorado State football in chaos over alleged coronavirus 'cover-up'
FORT COLLINS, Colo. — Colorado State president Joyce McConnell says she will launch an investigation into how the athletic department handled COVID-19 safety protocols amid a report that players were told not to reveal symptoms. The investigation stems from an article published in the Coloradoan on Tuesday. According to the newspaper report, Colorado State football...nypost.com
Kourtney Kardashian reveals her son, 5, shaved his waist-length hair: 'I am not ok'
Kourtney Kardashian's son Reign Disick no longer has long hair.foxnews.com
Undeterred by potential Trump ban, outside digital organizers rally enthusiasm for Joe Biden on TikTok
Outside digital organizers are capitalizing on TikTok to drum up enthusiasm for presumptive Democratic nominee Joe Biden, amid President Donald Trump's potential ban of the short form video app.edition.cnn.com
CDC warns of upcoming outbreak of life-threatening disease that targets children
The CDC is warning that it expects an outbreak of a rare, life-threatening disease that targets children, starting this month. The potentially deadly neurological and respiratory disease, acute flaccid myelitis, or AFM, has resurfaced in waves every two years in the US since 2014 — and typically strikes between August and November, the federal Centers...nypost.com
Passenger on Alaska cruise tests positive for COVID-19, prompting quarantine, canceled sailings
Passengers are quarantining on the ship until Alaska "deems it safe for them to return home," after one passenger tested positive for COVID-19.usatoday.com
Man proposes to girlfriend with candles, burns down their apartment
A man in England made his fiery love for his girlfriend official by popping the question with dozens of candles, in a heartfelt display that accidentally burned down their apartment.foxnews.com
Trump calls for first presidential debate to be moved up due to early, mail-in voting
President Trump in a "Fox & Friends" interview Wednesday morning called for the first presidential debate to be moved up, citing increased mail-in and early voting that will see many ballots cast in the presidential election before the first debate is held.foxnews.com
Fiona Hill, ex-Trump adviser who testified in impeachment, plans book on future of polarized America
Fiona Hill, a key witness in President Donald Trump's impeachment inquiry, is going to be sharing her views about the future of a polarized America.usatoday.com
Judge Rules Meghan Markle's Friends Can Remain Anonymous in Privacy Invasion Case Against British Newspaper
Meghan is seeking damages for alleged misuse of private information, copyright infringement and data protection breachestime.com
Beirut explosion: Pompeo says US is ready to help, Australia donates $1.4M as international community responds
Secretary of State Mike Pompeo was one of a number of high-ranking international officials to offer help to Lebanon in the wake of a devastating explosion that tore through Beirut on Tuesday, leaving at least 100 people dead and injuring thousands more.foxnews.com
New York Times' digital revenue exceeds print for first time ever
The nation's newspaper of record is looking more and more like a digital shop, and it has the subscription numbers to show it.edition.cnn.com
A nun on the radical possibilities of Christianity
A chapel on Santorini Volcano Island in the Aegean Sea in Greece on July 6, 2020. | Nicolas Economou/NurPhoto via Getty Images A conversation about love and suffering in Christianity. "One who lives in God lives in others because it is in the other that God is found." That's how Ilia Delio, a Franciscan nun and Catholic theologian, sums up her vision of Christianity. For Delio, much of what passes for Christianity today has become unmoored from the example of Christ. The result, she says, is an "abstract Christianity" that can't really speak to the pain and loss we're experiencing in this moment. I recently spoke with Delio as part of Future Perfect's new limited-series podcast, The Way Through, which is all about exploring the world's great philosophical and spiritual traditions for guidance during these difficult times. At the core of our conversation is the question of suffering and how we should respond to it. There's a version of Christianity that is mostly about dogma and institutional power — that's the Christianity I felt alienated from as a child. But there's another version, a "Christianity of deed" in Delio's words, that's all about sacrifice and love — and that's a Christianity I wanted to explore. We dig into what this kind of living faith might look like in the world, and what it would take to get us there. Subscribe to Future Perfect: The Way Through on Apple Podcasts, Google Podcasts, Spotify, Stitcher or wherever you listen to podcasts. Support Vox's explanatory journalism Every day at Vox, we aim to answer your most important questions and provide you, and our audience around the world, with information that has the power to save lives. Our mission has never been more vital than it is in this moment: to empower you through understanding. Vox's work is reaching more people than ever, but our distinctive brand of explanatory journalism takes resources — particularly during a pandemic and an economic downturn. Your financial contribution will not constitute a donation, but it will enable our staff to continue to offer free articles, videos, and podcasts at the quality and volume that this moment requires. Please consider making a contribution to Vox today.vox.com
Deadly Beirut blast wiped out 85% of grain silos
The blast occurred at Beirut's port, which manages 60% of all imports for Lebanon.foxnews.com
Trump: 'Teachers in a certain age group' should stay home in fall due to COVID-19
"If a teacher's in a certain age group, I think they shouldn't be going in and probably they'll have to wait until the thing goes by," Trump said during a "Fox & Friends" interview.nypost.com
The most alarming claims from USA TODAY's investigation into Texas Tech
SportsPulse: USA TODAY Sports obtained Texas Tech's exit interviews with players from the past two seasons via public records requests. In addition to reviewing those documents and others, USA TODAY Sports interviewed 10 players, two former assistant coaches and two parents about the program.usatoday.com
New York health department investigating Long Island nursing home after CBS News report
As coronavirus nursing home deaths continue to rise across the country, CBS News took a look at policies in New York and Florida that allow COVID-19 patients into long-term care facilities, and spoke to a former employee of a nursing home in New York who alleges COVID-19 patients were not separated from other residents, which may have led to deaths. David Begnaud reports from Miami.cbsnews.com
Big Ten announces schedule of 10 conference games to start Sept. 5
The Big Ten plans to kick off its Big Ten college football schedule of conference games on Sept. 5 but leave flexibility due to coronavirus concerns.usatoday.com
Trump said he may deliver convention speech from White House
President Donald Trump on Wednesday said he will "probably" deliver his Republican National Convention acceptance speech live from the White House after scrapping his plans to deliver the speech in Charlotte, North Carolina.edition.cnn.com
Oprah called a 'fraud' for calling out 'white privilege' since she's so rich
"Why is Oprah, maybe the richest black woman in the world, trying to shame white people?"nypost.com
Astronauts describe trip home aboard SpaceX capsule and what they would do differently next time
Mark Strassmann speaks to NASA astronauts Bob Behnken and Doug Hurley, who had a successful landing back on Earth. They describe their landing and what they can do better for next time. One astronaut's wife is going to be flying in the same capsule next year.cbsnews.com
Donald Trump: Black Lives Matter a 'Marxist Group' that Is Not Good for Our Country
President Donald Trump said Wednesday in an interview he believed the activist group Black Lives Matter was a "Marxist group."breitbart.com
Jets mailbag: What new cap space means in lingering Jadeveon Clowney saga
You ask, we answer. The Post is fielding questions from readers about New York's biggest pro sports teams and getting our beat writers to answer them in a series of regularly published mailbags. In today's installment: the Jets. [Jadeveon] Clowney would fill a big hole but at what cost? Problem is the Jets are not one player...nypost.com
Instagram's TikTok copycat Reels is now available in the US
Facebook has a long history of copying features from rivals, but even by that benchmark, Reels stands out.edition.cnn.com
Magic Johnson's advice for baseball players during coronavirus outbreak: 'You can't be selfish'
Magic Johnson knows about changing habits in order to live through a virus as an athlete.latimes.com
JaMychal Green provides a boost: Five takeaways from Clippers' loss to Suns
JaMychal Green did his part in trying to keep the Clippers from losing to Phoenix Suns on Tuesday, scoring 10 points off the bench in the 117-115 loss.latimes.com
Between renting and buying, Unagi offers personal scooters with a subscription
Unagi subscription plan starts in New York and Los Angeles. Service says pandemic brought its scooter sales from "hundreds" to "thousands."usatoday.com
Coronavirus fears complicate Apple fire evacuation plans
Coronavirus concerns mean some fire evacuees head to hotels, not shelters.latimes.com
Hollywood & Highland is getting a big makeover that includes turning stores into offices
The $100-million overhaul of the Hollywood & Highland shopping and entertainment center will bring offices to the complex and a new name: Ovation.latimes.com
UConn becomes first FBS team to cancel football season in 2020
The UConn Huskies football team became the first FBS program to cancel its 2020 season, citing safety challenges and scheduling issues.usatoday.com
'How many Quibis make an episode?' An 'SNL' vet re-imagines 'Murder, She Wrote'
Former "Saturday Night Live" head writer Paula Pell comes to Quibi with "Mapleworth Murders," a short-form, star-studded spin on "Murder, She Wrote."latimes.com
How gay feminist composer Pauline Oliveros taught us to hear with more than ears
Pauline Oliveros was one of the most radical composers of her time. Listen to her "The Well & The Gentle" and be changed by the experience.latimes.com
As Trump threatens ban, TikTok says it wants to fight foreign interference in the November election
TikTok, the embattled short-form video app owned by a Chinese tech firm, wants to stop the spread of online misinformation and fight foreign interference in November's US presidential election.edition.cnn.com
PEN America calls for Hollywood transparency on China censorship to 'protect artistic freedom'
The free expression advocacy group is encouraging greater transparency in Hollywood's dealings with China, as well as commitments to protect the globally released versions of films from Chinese government censorship.latimes.com
Instagram's answer to TikTok is here
One of these things is a lot like the other. | Jakub Porzycki/NurPhoto via Getty Images Meet Instagram Reels, the 15-second video platform that looks exactly like that other 15-second video platform. Today, Instagram is releasing its most significant update since Stories in 2016: Reels, an editing tool that allows users to craft 15-second clips set to music with options to add timed effects, has officially launched in the US. Users can access Reels from the camera in the upper left-hand corner, where you would normally go to film an Instagram Story, and then flipping through to the Reels tab. There, you can search an audio database, upload video clips and splice them together, add text, and play around with the speed or other effects, like greenscreen. Rebecca Jennings/Vox The Reels video tool, featuring my cat. Rebecca Jennings/Vox Reels, my cat, and Taylor Swift. If this sounds suspiciously similar to a different very popular social media app, well, yes. Reels is essentially Facebook's answer to TikTok, just as Instagram Stories were a pretty blatant copy of Snapchat's own disappearing Story feature. Reels and TikTok are, for the most part, functionally identical, and Instagram is positioning it as such: as a place to hop onto trending memes and dances, to create goofy content, and perhaps, ultimately, to find fame. Beyond the fun new editing features, though, what Instagram likely really wants to replicate is the endless scroll of TikTok's addictive For You page, which is personalized to each user and has been a huge key to TikTok's success. While the Explore tab on Instagram theoretically exists for the same purpose — to show users content they might like but aren't following yet — the launch of Reels coincides with a major revamp of Explore, which will now include a For You page-type endless scroll of vertical Reels videos. The launch comes just as TikTok faces mounting pressure from US leadership to sever ties with its Chinese owner, ByteDance, culminating in rumors that President Donald Trump will force a selloff. Facebook, which owns Instagram, has long considered TikTok a threat (Mark Zuckerberg tried to buy it in 2016). If Reels takes off, or if it replaces TikTok as the de facto platform for short-form time-wasting due to a political mandate outside TikTok's control, that's a huge win for Facebook. There are a few minor differences between the two: Reels has a feature called Align that makes it easier to line up clips for more seamless editing. On the new Explore page, Reels will also label certain particularly entertaining or trending videos as "featured," meaning they've been hand-selected by a person to appear in your feed. A user's Reels videos will also live in a tab separate from their Instagram grid, located next to the tab for tagged photos. Other than that, it's basically … TikTok, but on Instagram. For better or for worse, judging by Instagram's history, that may as well make it a hit. Support Vox's explanatory journalism Every day at Vox, we aim to answer your most important questions and provide you, and our audience around the world, with information that has the power to save lives. Our mission has never been more vital than it is in this moment: to empower you through understanding. Vox's work is reaching more people than ever, but our distinctive brand of explanatory journalism takes resources — particularly during a pandemic and an economic downturn. Your financial contribution will not constitute a donation, but it will enable our staff to continue to offer free articles, videos, and podcasts at the quality and volume that this moment requires. Please consider making a contribution to Vox today.vox.com
'Who's the Boss' Reboot In the Works with Tony Danza and Alyssa Milano
The classic sitcom is returning to the small screen.nypost.com
Trump campaign, RNC sue Nevada over expansion of mail-in voting
The lawsuit takes aim at a new bill signed by Governor Steve Sisolak on Monday.cbsnews.com
Coronavirus relief must focus on jobs, not 'force' people to choose between work and unemployment, Hawley says
The coronavirus relief package should focus on jobs not some "$3-plus trillion dollars of bailout money for blue states of spending on special interest lobbying projects," Sen. Josh Hawley, R-Mo., told "Fox & Friends" Wednesday.foxnews.com
Hilary Duff shows off toned abs in new bikini pic, encourages fans to 'do whatever feels good'
Hilary Duff is flaunting her figure and encouraging her fans to do what that makes them happy, all at once.foxnews.com
Activist Cori Bush upsets 10-term incumbent US Rep. William Lacy Clay in Missouri primary
Missouri Democratic congressional candidate Cori Bush upset longtime Rep. William Lacy Clay in Missouri's Democratic primary on Aug. 4, 2020.usatoday.com
Meet Members of a Historic University of California Class
Wednesday: Latinos were the largest group of Californians admitted to the university's freshman class. Also: A deeper look at the life of Representative Karen Bass.nytimes.com
NFL's Stephon Clark video omits 'crucial facts' in police-involved shooting case, prosecutors say
An NFL video highlighting the police-involved death of Stephon Clark in 2018 "performs a disservice instead of a public service," California prosecutors said Tuesday.foxnews.com
President Trump flips on his longstanding attitude toward mail-in ballots
President Trump has repeatedly denounced mail-in ballots, but he is changing his tune for Florida. Weijia Jiang reports.cbsnews.com
'Who's the Boss?' reboot confirmed by Tony Danza and Alyssa Milano
We are waiting on you, Judith Light. Tony Danza and Alyssa Milano say that a reboot of "Who's the Boss?" is in the works.edition.cnn.com
Beirut explosion reportedly caused by fertilizer seized from Russian businessman
The 2,700 tons of fertilizer believed to have caused the explosion that devastated Beirut had been confiscated from a Russian businessman — who "abandoned" his cargo ship after an unscheduled stop, according to reports. Officials revealed Tuesday that the blast that killed at least 100 — and left up to 300,000 homeless — appeared to...nypost.com
'Who's the Boss' reboot starring Alyssa Milano, Tony Danza in development by Sony
"Who's the Boss?" is the latest 1980s sitcom to get the modern-day reboot treatment, Sony Pictures Television announced Tuesday.foxnews.com


text:
Necklace handmade by Hitomi Nakasone
Cranked up by Burcu Gozler
Gemstone: Garnet
Bead size: 6mm
Length: 47cm 19in
Garnet is a very powerful stone for bringing your core energy together helping solidify it. Giving you fortitude, balance and strength. Garnet also helps with the heart, having the deep frequencies of love.
This necklace is made of 100% genuine AAA Garnet beads. All the items I hand craft are made using the highest quality gemstones.
All of the stones have been energetically cranked up by Burcu Gozler; this energy crank up is a permanent feature that will stay within the stone forever. Burcu's energy bonds with the stones' frequencies and makes them energetically stronger than stones that have not been cranked up. This in turn assists the wearer of this necklace even more so!
To purchase this necklace from Etsy, click here: Garnet Necklace
To learn more about Burcu Gozler and her energy crank ups, click here: http://www.burcugozler.com/
To return to the list of Hitomi Nakasone's jewelry, click here: Hand Made Energy Jewelry


text: Thanks to everyone who came out for shows at the State Theatre in Easton, PA and Infinity Hall in Hartford, CT! Our first time at the State Theatre in Easton, PA , and what an audience! We are happy to announce we have been asked back next year! We traveled from the State Theatre to do a show for Infinity Hall in Hartford, CT for another great night!


text:
140 Showplace Blvd, Pigeon forge, TN 37863
sale $2,500,000 | Fee Simple Improved
Courtesy Of Prime Mountain Properties
BEAUTIFUL THEATER ON 2.25 ACRES IN THE HEART OF PIGEON FORGE! SIGN ON PARKWAY! MAGNIFICENT MOUNTAIN VIEWS!!! This is a terrific LOCATION right between HOLLYWOOD WAX MUSEUM and COUNTRY TONITE. Gorgeous interior with high ceilings and beautiful wood beams! Features include: stage, tiered seating and seats (approximately 300-325), lobby area, concessions area, office spaces, storage rooms, public restrooms, personnel restrooms, staff lounge area, large dressing rooms. One room has its own bathroom and private entrance. Roof was installed in 2014. Two years ago theater was painted entirely on inside, new carpet installed, and restrooms updated. Terrific outside seating area that offers those great Smoky Mountain Views! This 8,000+/- square foot building is waiting for your business! Would make a great Convention Center, Church, Restaurant (it used to be Eddie's Heart and Soul Cafe-dinner and a show). Possibilities are endless!
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Copyright © 2020 Great Smoky Mountains Association of Realtors. All rights reserved. All information provided by the listing agent/broker is deemed reliable but is not guaranteed and should be independently verified. Information being provided is for consumers' personal, non-commercial use and may not be used for any purpose other than to identify prospective properties consumers may be interested in purchasing.
Property Features
- Age: 21-30 Years Old
- Architecture Style: Other
- Cooling System: Central A/C
- Exterior Type: Stucco
- Exterior Type: Stone
- Heating Fuel: Natural Gas
- Heating System: Forced Air
- Roof Type: Unknown
Data powered by Attom Data Solutions. Copyright© 2020. Information deemed reliable but not guaranteed.
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