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Increased Growth Inhibitory Effects on Human ... - ACS Publications
Increased Growth Inhibitory Effects on Human ... - ACS Publications
Oct 30, 2009 - ... Institute, North Carolina Central University, North Carolina Research Campus .... Ginger Compound [6]-Shogaol and Its Cysteine-Conj...
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J. Agric. Food Chem. 2009, 57, 10645–10650
Increased Growth Inhibitory Effects on Human Cancer Cells and Anti-inflammatory Potency of Shogaols from Zingiber officinale Relative to Gingerols )
Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers University, 164 Frelinghuysen Road, Piscataway, New Jersey 08854-8020, ‡Human Nutrition Research Program, Julius L. Chambers Biomedical/Biotechnology Research Institute, North Carolina Central University, North Carolina Research Campus, 500 Laureate Way, Kannapolis, North Carolina 28081, Department of Food Science, Rutgers University, 65 Dudley Road, New Brunswick, New Jersey 08901-8520, ^Department of Seafood Science, National Kaohsiung Marine University, Kaohsiung 811, Taiwan, and #Sabinsa Corporation, 70 Ethel Road West, Unit 6, Piscataway, New Jersey 08854. § Current address: Division of Food Science, College of Natural Science, Seoul Women's University, Seoul 139-774, Korea.
Ginger, the rhizome of the plant Zingiber officinale, has received extensive attention because of its antioxidant, anti-inflammatory, and antitumor activities. Most researchers have considered gingerols as the active principles and have paid little attention to shogaols, the dehydration products of corresponding gingerols during storage or thermal processing. In this study, we have purified and identified eight major components, including three major gingerols and corresponding shogaols, from ginger extract and compared their anticarcinogenic and anti-inflammatory activities. Our results showed that shogaols ([6], [8], and [10]) had much stronger growth inhibitory effects than gingerols ([6], [8], and [10]) on H-1299 human lung cancer cells and HCT-116 human colon cancer cells, especially when comparing [6]-shogaol with [6]-gingerol (IC50 of ∼8 versus ∼150 μM). In addition, we found that [6]-shogaol had much stronger inhibitory effects on arachidonic acid release and nitric oxide (NO) synthesis than [6]-gingerol. KEYWORDS: Ginger; Zingiber officinale; [6]-gingerol; [6]-shogaol; inflammation; cancer
*To whom correspondence should be addressed. Telephone: 704250-5726. Fax: 704-250-5727. E-mail:
[email protected]
Recently, ginger has received extensive attention as a botanical dietary supplement in the U.S.A. and Europe because of its antioxidative, anti-inflammatory, and antitumor activities (4, 5). Although most of the animal studies with ginger extract showed antioxidative, anti-inflammatory, and antitumor activities, no report has considered the instability of gingerols during the thermal process and long-term storage will affect the chemical profile of the ginger extract used in their animal studies. They either did not quantify the levels of the active components in their raw material or simply used the total levels of gingerols as the standard. The nature of the active components in ginger has not been fully explored. It has been reported that topical application of [6]-gingerol or [6]-paradol onto shaven backs of female ICR mice prior to each topical dose of 12-O-tetradecanoylphorbol-13acetate (TPA) significantly inhibited 7,12-dimethylbenz[R]anthracene (DMBA)-induced skin tumor incidence and tumor burden (6). The same group also found that [6]-gingerol inhibited TPA-induced cyclooxygenase-2 (COX-2) expression in mouse skin in vivo by blocking the p38 MAP kinase-NF-κB signaling pathway (7). [6]-Gingerol was found to decrease the number of lung metastasis in mice implanted with B16F10 melanoma cells (8). Jeong et al. reported that [6]-gingerol effectively suppressed in vivo tumor growth in HCT-116 cancer cell-bearing
© 2009 American Chemical Society
Published on Web 10/30/2009
Ginger (Zingiber officinale Rosc.), a member of the Zingiberaceae family that consists of 47 genera, including Zingiber and Curcuma, has been cultivated for thousands of years as a spice and for medicinal purposes. The gingerols, a series of homologues differentiated by the length of their unbranched alkyl chains, were identified as the major pungent components in the ginger oleoresin from fresh rhizome, with [6]-gingerol (Figure 1) being the most abundant (1). Gingerols are not stable during storage or thermal processing to generate the dehydration products, shogaols, which are predominant pungent constituents in the ginger oleoresin from dried ginger (1, 2). It has been reported that shogaols were minor components in fresh ginger, and the ratio of [6]-shogaol/[6]-gingerol was about 1:1 in dried ginger (1,2). Other gingerol- or shogaol-related compounds have also been reported in ginger rhizome, such as [6]-paradol, [6]- and [10]-dehydrogingerdione, [6]- and [10]-gingerdione, [4]-, [6]-, [8]-, and [10]gingerdiol, [6]-methylgingerdiol, zingerone, [6]-hydroxyshogaol, [6]-, [8]-, [10]-dehydroshogaol, and diarylheptanoids (1-3). However, these minor compounds only count for about 1-10% of those for the overall amount of gingerols and shogaols (1-3).
J. Agric. Food Chem., Vol. 57, No. 22, 2009
Sang et al.
Figure 1. Structures of the eight major components purified from ginger extract.
nude mice (9). Several in vitro studies have found that shogaols also have anti-inflammatory and anticancer activities. It has been reported that [6]-shogaol significantly suppressed the expression of inducible nitric oxide sysnthesis and COX-2 in lipopolysaccharide (LPS)-induced macrophages (10). Wei et al. found that [6]- and [10]-shogaol could significantly inhibit the growth of HL-60 human leukemia cells. Rhode et al. reported that [6]-, [8]-, and [10]-gingerol had no effect and [6]-shogaol could significantly inhibit the growth of A-2780 ovarian cancer cells (11). Pan et al. found that [6]-shogaol inhibited the growth of human colon COLO-205 cells and induced apoptosis through modulation of mitochondrial functions regulated by reactive oxygen species (12). Kim et al. reported that [6]shogaol had much stronger growth inhibitory effects on A-549 human lung cancer cells, SK-OV-3 human ovarian cancer cells, SKMEL-2 human skin cancer cells, and HCT-15 human colon cancer cells than [4]-, [6]-, [8]-, and [10]-gingerol (13). To further study whether shogaols have better anti-inflammatory and anticancer activities than corresponding gingerols, we purified and identified eight major components, including three major gingerols ([6]-, [8]-, and [10]-gingerol), corresponding shogaols, [6]-paradol, and [1]-dehydrogingerdione, from ginger extract and compared their growth inhibitory effects against human lung and colon cancer cells and the inhibition of arachidonic acid release and nitric oxide (NO) synthesis from LPSstimulated RAW 264.7 cells. MATERIALS AND METHODS
Materials. Ginger extract, which contains 20% gingerols and shogaols, was obtained from Sabinsa Corporation (Piscataway, NJ). RP C-18 silica gel, silica gel, Sephadex LH-20 gel, thin-layer chromatography (TLC) plates (250 μm thickness, 2-25 μm particle size), CD3OD, and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) were purchased from Sigma (St. Louis, MO). High-performance liquid chromatography (HPLC)-grade solvents and other reagents were obtained from VWR Scientific (South Plainfield, NJ). HPLC-grade water was prepared using a Millipore Milli-Q purification system (Bedford, MA). H-1299 human lung cancer cells, HCT-116 human colon adenocarcinoma cells, and RAW 264.7 murine macrophages were obtained from American Type Tissue Culture (Manassas, VA). Nuclear Magnetic Resonance (NMR). 1H (400 MHz), 13C (100 MHz), and all 2D NMR spectra were acquired on a Varian 400 instrument (Varian, Inc., Palo Alto, CA). Compounds were analyzed in CD3OD, with tetramethylsilane (TMS) as the internal standard. 1H-13C heteronuclear multiple-quantum correlation (HMQC) and heteronuclear multiple-band correlation (HMBC) experiments were performed as described previously (14).
HPLC Analysis. HPLC analysis was carried out with a system consisting of a Waters 717 refrigerated autosampler, a HITACHI L-6200A intelligent pump, and an ESA 5600 coulochem electrode array system (CEAS). The potentials of the CEAS were set at 0, 200, 300, and 400 mV. The column used was a 150 4.6 mm inner diameter, 5 μm, Supelcosil RP-18. For binary gradient elution, mobile-phase A (1.75% acetonitrile and 0.12% tetrahydrofuran in 30 mM NaH2PO4 at pH 3.35) and B (58.5% acetonitrile and 12.5% tetrahydrofuran in 15 mM NaH2PO4 at pH 3.45) were used. The flow rate was maintained at 1 mL/min, and the mobile phase began with 100% A. It was followed by progressive linear increases in B to 65% at 15 min and 100% at 35 min. The mobile phase was maintained at 100% B for 10 min and then was re-equilibrated to 100% A at 46 min for another run. The HPLC profile of the ginger extract displaying these eight compounds is shown in Figure 2. Isolation of the Major Constituents in the Ginger Extract. The ginger extract (50 g) was chromatographed on a Sephadex LH-20 column with 95% ethanol as an eluant to remove the nonphenolic compounds (Fraction 1, 21.8 g) and to generate the gingerol- and shogaol-enriched fraction (fraction 2, 28 g). Fraction 2 was then loaded into a Diaion HP-20 column, eluted first with water to remove the water-soluble compounds and then with 40% aqueous ethanol to obtain fraction A (9 g), followed by 95% aqueous ethanol to obtain fraction B (11 g). Fraction A (5 g) was subjected to a normal phase silica-gel column with a stepwise gradient of hexane/ethyl acetate [9:1; 8:2, and 7:3] to give pure [6]-gingerol (2 g), [8]gingerol (0.5 g), and [10]-gingerol (0.4 g). Fraction B (5 g) was also subjected to a normal phase silica-gel column with a stepwise gradient of hexane/ethyl acetate (9:1 and 8:2) to generate 13 fractions. Fraction B5 (1 g) was subjected to a C-18 reverse-phase column eluted with a stepwise gradient of methanol/water [3:2, 7:3, and 4:1] to give [6]-paradol (40 mg), [1]-dehydrogigerdione (60 mg), and [10]-shogaol (120 mg). Following a similar procedure, fraction B7 (1.5 g) gave 200 mg of [8]-shogaol and 1 g of [6]-shogaol. The purification procedure was guided by TLC and HPLC analyses. The structures of these eight compounds were confirmed on the basis of their 1H and 13C NMR analyses (Figure 1). Growth Inhibition against Human Lung and Colon Cancer Cells. Cell growth inhibition was determined by the MTT assay (15). The cells were plated in 96-well microtiter plates and allowed to attach for 24 h at 37 C. The test compounds [in dimethylsulfoxide (DMSO)] were added to cell culture medium to desired final concentrations (final DMSO concentrations for control and treatments are 0.1%). After the cells were cultured for 24 h, the medium was aspirated and the cells were treated with 100 μL of fresh medium containing 2.41 mmol/L MTT. After incubation for 1-3 h at 37 C, the MTTcontaining medium was aspirated, 100 μL of DMSO was added to solubilize the formazan precipitate, and the plate was read at 550 nm on a microtiter plate reader. The reading reflected the number of viable cells and was expressed as a percentage of viable cells in the control. Both H-1299 and HCT-116 cells were cultured in McCoy's 5A
J. Agric. Food Chem., Vol. 57, No. 22, 2009
Figure 2. HPLC-electrochemical detection (ECD) profiles of ginger extract: peak 1, [6]-gingerol; peak 2, [8]-gingerol; peak 3, [6]-shogaol; peak 4, [6]-paradol; peak 5, [1]-dehydrogingerdione; peak 6, [10]-gingerol; peak 7, [8]-shogaol, and peak 8, [10]-shogaol.
Figure 3. Effects of [6]-, [8]-, and [10]-gingerol, [6]-, [8]-, and [10]-shogaol, [6]-paradol, and [1]-dehydrogingerdione on the growth of H1299 human lung cancer cells and HCT-116 human colon adenocarcinoma cells. Each value represents the mean ( standard deviation (SD) (n = 8). medium. All of the above media were supplemented with 10% fetal bovine serum, 1% penicillin/streptomycin, and 1% glutamine, and the cells were kept in a 37 C incubator with 95% humidity and 5% CO2.
Inhibition of Arachidonic Acid Release from LPS-Stimulated RAW 264.7 Cells. To determine the inhibition of arachidonic acid
release, RAW 264.7 cells were plated into a 24-well plate (3 105 cells per well). After 24 h, the media were removed and replaced with 1 mL of serum-free Dulbecco's modified Eagle's medium (DMEM) containing 0.1 μCi/mL [5, 6, 8, 9, 11, 12, 14, and 15 3H] (N) arachidonic acid (NEN Life Science, Boston, MA). The cells were incubated overnight, resulting in over 90% arachidonic acid absorption, and washed twice with phosphatebuffered saline (PBS) containing 0.1% bovine serum albumin (BSA). The
cells were stimulated with 2 μg/mL LPS for 1 h, and the media were replaced with serum-free medium containing the test compounds with desired final concentrations. After incubation for 18 h, the media were collected and centrifuged for 10 min at 12 000 rpm. Radioactivity in the extracellular fluid was measured with a scintillation counter. RAW 264.7 cells were maintained in log-phase growth in DMEM. Inhibition of NO Synthesis. RAW 264.7 cells were plated in 24-well plates (3.0 105 cells per well) and stimulated for 1 h with 1 μg/mL LPS and 10 ng/mL interferon γ (IFNγ). The media were then replaced with serum-free medium containing compounds with desired final concentrations, and cells were cultured for 24 and 30 h. NO production was determined spectrophotometrically using previously reported methods (16).
J. Agric. Food Chem., Vol. 57, No. 22, 2009
Sang et al.
Figure 4. Effects of (A) [6]-shogaol and (B) [6]-gingerol on arachidonic acid release in LPS-stimulated RAW264.7 cells. Each bar represents the mean ( SD (n = 8). (/ and //) Significantly different from the control according to Student's t test (/, p < 0.05; //, p < 0.01).
Statistical Analysis. For simple comparisons between two groups, a two-tailed Student's t test was used. A p value of less than 0.05 was considered statistically significant in all of the tests. RESULTS AND DISCUSSION
Purification and Structure Elucidation. Ginger extract was chromatographed successively on Sephadex LH-20, Diaion HP20, normal phase silica-gel, and/or RP-C18 columns to afford [6]-, [8]-, and [10]-gingerol, [6]-, [8]-, and [10]-shogaol, [6]-paradol, and [1]-dehydrogingerdione (compounds 1-8) (Figure 1). Their structures were determined by a comparison of their NMR and MS data to those reported in the literature (13, 17, 18). Then, we developed a HPLC method using an electrochemical array detector (ECD) to analyze those eight components (Figure 2). This method is about 50-100-fold more sensitive than the UV detection method reported in previous literature (19). The limit of detection is ∼1-2 ng/mL for all eight components, and the limit of quantification is ∼2-4 ng/mL for all eight components. Inhibitory Effects on the Proliferation of Human Lung and Colon Cancer Cells. The growth inhibitory activities of compounds 1-8 were determined after treatment for 24 h in H-1299 human lung cancer cells and in HCT-116 human colon cancer cells. Our results indicated that [6]-, [8]-, and [10]-gingerol and [6]-paradol showed effective inhibition on H-1299 cells with [10]-gingerol > [8]-gingerol> [6]-paradol> [6]-gingerol. However, shogaols ([6], [8], and [10]) had much stronger growth inhibitory effects than gingerols ([6], [8], and [10]) on H-1299 human lung cancer cells, especially when comparing [6]-shogaol to [6]-gingerol (IC50 of ∼8 versus ∼150 μM) (panels A and B of Figure 3). The inhibitory effects of [6]-, [8]-, and [10]-shogaol exhibited an order of [6]shogaol > [8]-shogaol > [10]-shogaol and were much stronger than the effects of [1]-dehydrogingerdione. Similarly, we found that shogaols ([6], [8], and [10]) had much stronger growth inhibitory effects than gingerols ([6], [8], and [10]) on HCT-116 human colon cancer cells (panels C and D of Figure 3). HCT-116 cells were less sensitive to both [6]-shogaol and [6]-gingerol treatments than H-1299 cells. Inhibitory Effects on Arachidonic Acid Release. After stimulation of the cells with 2 μg/mL LPS for 1 h, the release of arachidonic acid and its metabolites from RAW264.7 macrophage cells to the culture media increased ∼3-fold after 18 h of incubation. At 5 μM, [6]-shogaol significantly decreased the release of arachidonic acid and its metabolites during the 18 h
incubation (∼90% inhibition) (Figure 4A). This is much more effective than 50 μM [6]-gingerol, which yielded ∼30% inhibition (Figure 4B). Inhibitory Effects on NO Synthesis. After stimulation of RAW264.7 cells with 1 μg/mL LPS and 10 ng/mL IFNγ for 1 h, significant NO accumulation in culture medium was observed at 24 h and much higher accumulation of NO was observed at 30 h. Our results indicated that both [6]-shogaol and [6]-gingerol significantly inhibited NO accumulation (p < 0.01) (Figure 5A), whereas [6]-shogaol at 5 μM has much stronger inhibitory effects than [6]-gingerol at 35 μM (Figure 5A). The inhibitory effect of [6]-shogaol was concentration-dependent, with significant inhibition observed at a concentration as low as 1.25 μM (Figure 5B). One of the challenges to study the in vivo efficacy of [6]-gingerol and [6]-shogaol is that both compounds are not commercially available with affordable prices. In this study, we found that the Diaion HP-20 column chromatogram is a useful tool to separate [6]-gingerol and [6]-shogaol in large quantities. We recently further polished our purification methods. We found that 1 kg of Diaion HP-20 resin could load 100 g of ginger extract. [6]-Gingerol with 90% purity could be eluted by 40% aqueous ethanol, and [6]-shogaol could be eluted out by 75% aqueous ethanol through a Diaion HP-20 column. Both [6]-gingerol- and [6]-shogaol-enriched fractions could be further purified using a RP C-18 column to generate [6]-gingerol and [6]-shogaol with more than 95% purity. Therefore, large quantities (10-20 g) of [6]-gingerol and [6]-shogaol can be purified from ginger extract within 4 weeks. Because both Diaion HP-20 resin and RP C-18 silica gel are reusable, the purification method developed in this study will be very practical to prepare large quantities of [6]gingerol and [6]-shogaol in an academic lab or a botanical company to support future in vivo studies. In this study, we purified eight major ginger components, including [6]-, [8]-, and [10]-shogaols and related gingerols from ginger extract, and compared their anticarcinogenic and antiinflammatory effects. Our results indicated that shogaols ([6], [8], and [10]) had much stronger growth inhibitory effects than gingerols ([6], [8], and [10]) on H-1299 human lung cancer cells and HCT-116 human colon cancer cells, especially when comparing [6]-shogaol to [6]-gingerol. This is the first study to show that both shogaols and gingerols could significantly inhibit the growth of H-1299 human lung cancer cells. It has been reported that [6]gingerol effectively suppressed in vivo tumor growth in HCT-116 human colon cancer cell-bearing nude mice. Our results indicated
J. Agric. Food Chem., Vol. 57, No. 22, 2009
Figure 5. Effects of [6]-shogaol and [6]-gingerol on NO synthesis in LPS/IFNγ-stimulated RAW264.7 cells. (A) Levels of NO in the culture medium of LPS/ IFNγ-stimulated RAW264.7 cell were analyzed at different time points after treatment with 5 μM [6]-shogaol and 35 μM [6]-gingerol. (B) Concentrationdependent effects of [6]-shogaol on NO release was analyzed after 24 h of incubation. (/ and //) Significantly different from the control according to Student's t test (/, p < 0.05; //, p < 0.01). Each bar represents the mean ( SD (n = 8).
that [6]-shogaol had much stronger inhibitory effects than [6]-gingerol on the growth of HCT-116 cancer cells in vitro. Therefore, it is worthwhile to further study whether [6]-shogaol has a stronger inhibitory effect to suppress in vivo tumor growth in HCT-116 colon cancer cell-bearing nude mice. In addition, we found that both [6]-shogaol and [6]-gingerol were extensively metabolized under cell culture conditions (unpublished data). We did not observe any conversion between [6]-shogaol and [6]-gingerol in the cell medium after 24 h of incubation. We are in the process of purifying and identifying the major metabolites of [6]-shogaol and [6]-gingerol. Whether their metabolites have anticancer activities merits further investigation. The shogaols are the dehydration products of related gingerols during storage or thermal processing (2, 3). Therefore, the contents of shogaols and gingerols in ginger preparations can vary greatly. This may have contributed to the inconsistencies in published effects of ginger preparations. Thus, ginger extracts with high levels of shogaols, such as extracts from dry ginger, may have stronger cancer-preventive effects than ginger extracts with high levels of gingerols, such as extracts from fresh ginger. It is important to identify the bioactive components in ginger and standardize the products for use in future laboratory studies and clinical trials. The development of a standardized and more active ginger extract preparation will facilitate future preclinical and clinical studies on the health benefits of ginger extracts. Both arachidonic acid metabolites and NO are important mediators of oxidative stress and inflammation in vivo. Many studies have shown that arachidonic acid and its metabolites as well as NO play important roles in the development of cancer (20, 21). An increasing number of studies have indicated that inhibitors of arachidonic acid cascade and NO synthesis have potential therapeutic value for cancer prevention (22-28). The present results demonstrate that [6]-shogaol is capable of inhibiting both of these processes in LPS-induced murine macrophages. The inhibition of arachidonic acid release may be caused by a blockage of phospholipase A2 activation or activity, and further mechanistic studies are required. Similarly, the mechanism for the inhibition of NO synthesis by LPS/IFNγ-activated macrophages is not clear. [6]-Shogaol may inhibit either iNOS activity or LPS induction of the enzyme. Further studies are needed to determine the mechanism(s) of action of shogaols.
Supporting Information Available: NMR (1H and 13C) data for [6]-, [8]-, and [10]-gingerol, [6]-, [8]-, and [10]-shogaol, [6]paradol, and [1]-dehydrogingerdione. This material is available free of charge via the Internet at http://pubs.acs.org. LITERATURE CITED (1) Govindarajan, V. S. Ginger;Chemistry, technology, and quality evaluation: Part 1. Crit. Rev. Food Sci. Nutr. 1982, 17, 1–96. (2) Ravindran, P. N. B. N. K. Ginger: The Genus Zingiber; CRC Press: Boca Raton, FL, 2005; pp 1-15, 87-115. (3) Ali, B. H.; Blunden, G.; Tanira, M. O.; Nemmar, A. Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): A review of recent research. Food Chem. Toxicol. 2008, 46, 409–420. (4) Shukla, Y.; Singh, M. Cancer preventive properties of ginger: A brief review. Food Chem. Toxicol. 2007, 45, 683–690. (5) Surh, Y. J. Anti-tumor promoting potential of selected spice ingredients with antioxidative and anti-inflammatory activities: A short review. Food Chem. Toxicol. 2002, 40, 1091–1097. (6) Park, K. K.; Chun, K. S.; Lee, J. M.; Lee, S. S.; Surh, Y. J. Inhibitory effects of [6]-gingerol, a major pungent principle of ginger, on phorbol ester-induced inflammation, epidermal ornithine decarboxylase activity and skin tumor promotion in ICR mice. Cancer Lett. 1998, 129, 139–144. (7) Kim, S. O.; Kundu, J. K.; Shin, Y. K.; Park, J. H.; Cho, M. H.; Kim, T. Y.; Surh, Y. J. [6]-Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-κB in phorbol esterstimulated mouse skin. Oncogene 2005, 24, 2558–2567. (8) Kim, E. C.; Min, J. K.; Kim, T. Y.; Lee, S. J.; Yang, H. O.; Han, S.; Kim, Y. M.; Kwon, Y. G. [6]-Gingerol, a pungent ingredient of ginger, inhibits angiogenesis in vitro and in vivo. Biochem. Biophys. Res. Commun. 2005, 335, 300–308. (9) Jeong, C. H.; Bode, A. M.; Pugliese, A.; Cho, Y. Y.; Kim, H. G.; Shim, J. H.; Jeon, Y. J.; Li, H.; Jiang, H.; Dong, Z. [6]-Gingerol suppresses colon cancer growth by targeting leukotriene A4 hydrolase. Cancer Res. 2009, 69, 5584–5591. (10) Pan, M. H.; Hsieh, M. C.; Hsu, P. C.; Ho, S. Y.; Lai, C. S.; Wu, H.; Sang, S.; Ho, C. T. 6-Shogaol suppressed lipopolysaccharide-induced up-expression of iNOS and COX-2 in murine macrophages. Mol. Nutr. Food Res. 2008, 52, 1467–1477. (11) Rhode, J.; Fogoros, S.; Zick, S.; Wahl, H.; Griffith, K. A.; Huang, J.; Liu, J. R. Ginger inhibits cell growth and modulates angiogenic factors in ovarian cancer cells. BMC Complementary Altern. Med. 2007, 7, 44.
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(12) Pan, M. H.; Hsieh, M. C.; Kuo, J. M.; Lai, C. S.; Wu, H.; Sang, S.; Ho, C. T. 6-Shogaol induces apoptosis in human colorectal carcinoma cells via ROS production, caspase activation, and GADD 153 expression. Mol. Nutr. Food Res. 2008, 52, 527–537. (13) Kim, J. S.; Lee, S. I.; Park, H. W.; Yang, J. H.; Shin, T. Y.; Kim, Y. C.; Baek, N. I.; Kim, S. H.; Choi, S. U.; Kwon, B. M.; Leem, K. H.; Jung, M. Y.; Kim, D. K. Cytotoxic components from the dried rhizomes of Zingiber officinale Roscoe. Arch. Pharm. Res. 2008, 31, 415–418. (14) Fang, X.; Qiu, F.; Yan, B.; Wang, H.; Mort, A. J.; Stark, R. E. NMR studies of molecular structure in fruit cuticle polyesters. Phytochemistry 2001, 57, 1035–1042. (15) Momann, T. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J. Immunol. Methods 1983, 65, 55–63. (16) Ryu, J. H.; Ahn, H.; Jin Lee, H. Inhibition of nitric oxide production on LPS-activated macrophages by kazinol B from Broussonetia kazinoki. Fitoterapia 2003, 74, 350–354. (17) Charles, R.; Garg, S. N.; Kumar, S. New gingerdione from the rhizomes of Zingiber officinale. Fitoterapia 2000, 71, 716–718. (18) Shoji, N.; Iwasa, A.; Takemoto, T.; Ishida, Y.; Ohizumi, Y. Cardiotonic principles of ginger (Zingiber officinale Roscoe). J. Pharm. Sci. 1982, 71, 1174–1175. (19) Schwertner, H. A.; Rios, D. C. High-performance liquid chromatographic analysis of 6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol in ginger-containing dietary supplements, spices, teas, and beverages. J. Chromatogr., B: Anal. Technol. Biomed. Life Sci. 2007, 856, 41–47. (20) Coulter, J. A.; McCarthy, H. O.; Xiang, J.; Roedl, W.; Wagner, E.; Robson, T.; Hirst, D. G. Nitric oxide;A novel therapeutic for cancer. Nitric Oxide 2008, 19, 192–198. (21) Hyde, C. A.; Missailidis, S. Inhibition of arachidonic acid metabolism and its implication on cell proliferation and tumour-angiogenesis. Int. Immunopharmacol. 2009, 9, 701–715. (22) Benavente-Garcia, O.; Castillo, J. Update on uses and properties of citrus flavonoids: New findings in anticancer, cardiovascular, and
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Received for review August 5, 2009. Revised manuscript received October 16, 2009. Accepted October 19, 2009. This work was supported by National Institutes of Health (NIH) Grant CA138277 to S. Sang.
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Responsible for managing the complete life cycle of moderately-to-highly
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achieve goals. Coordinates the activities of a cross-functional team
including exempt and non-exempt employees. Has in-depth experience,
knowledge and skills in own discipline. Usually determines own work
priorities. Acts as resource for colleagues with less experience.
Employees at all levels are expected to:
- Understand our Operating Principles; make them the guidelines for how
you do your job
- Own the customer experience - think and act in ways that put our
customers first, give them seamless digital options at every touchpoint,
and make them promoters of our products and services
- Know your stuff - be enthusiastic learners, users and advocates of our
game-changing technology, products and services, especially our digital
tools and experiences
- Win as a team - make big things happen by working together and being
open to new ideas
- Be an active part of the Net Promoter System - a way of working that
brings more employee and customer feedinto the company - by joining
huddles, making call backs and helping us elevate opportunities to do
better for our customers
- Drive results and growth
- Respect and promote inclusion and diversity
- Do what's right for each other, our customers, investors and our
Core Responsibilities:
- Provides research and assistance to leadership in the development and
design of new projects.
- Uses formal processes and tools to manage resources, budgets, risks,
and changes.
- Manages project status and information in the form of formal
briefings, project update meetings, and written, electronic, and graphic
- Develops, maintains, and manages detailed project plans, action item
registers, and major milestone timelines for all assigned projects.
Provides overall prioritization and director of work assignments, team
resources, etc. Monitor and creates project deliverables.
- Coordinates with other work streams, projects, and initiatives which
may impact successful completion of project.
- Manages all assigned projects to completion ensuring on-time delivery,
meeting of budgetary demands, and maintaining overall project
- Acts as a single point of contact for project status. Maintains
communication with stakeholders.
- Facilitates project meetings.
- Addresses problems through risk management and contingency planning
and presents solutions and/or options to executive management. Ensures
effective implementation of solutions/changes.
- Consistent exercise of independent judgment and discretion in matters
of significance.
- Regular, consistent and punctual attendance. Must be able to work
nights and weekends, variable schedule(s) as necessary.
- Other duties and responsibilities as assigned.
Job Specification:
- Bachelors Degree or Equivalent
- Business
- Generally requires 5-7 years related experience>
- Generally requires 5-7 years related experience>

subset: commoncrawl


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Understanding Low Sperm Morphology
What is low sperm morphology?
The semen a male produces with each male ejaculation contains an average of 69 million individual sperm. When less than 4% of these sperm are a normal shape, a male is considered to have a sperm morphology problem. Having some unusually shape sperms is not an issue until it reaches this low point, and this is only a health concern if a couple is trying to get pregnant.
A normally shaped sperm should have a head, middle connection and long tail. If too many have abnormal shapes with pin heads, double-heads, absent tails than there is a problem for couples trying to get pregnant.
How Do I Know if I have Sperm Morphology?
The only way to find out if there is any issue you with your sperm is to go in to see a doctor. At the appointment you will be asked to ejaculate into a cup. After this the doctor will examine your semen for any problems under a microscope. They will check for the sperm motility, sperm morphology, semen volume, the total sperm count and sperm concentration. All of these tests will ensure that you know what is wrong or not wrong with the sperm, which can be a relief to a couple trying to conceive.
Some patients feel extremely uncomfortable with this appointment for a variety of reasons. Talking about sperm, semen and other substances of an intimate nature isn't something most of us want to talk to everyone about. Just keep in mind that to your doctor it is just another day in the office, and this isn't the first time they've looked at semen under a microscope.
Can We Still Get Pregnant?
When a doctor diagnoses a patient with sperm morphology the general course of action is to first wait and see if the couple will get pregnant without treatment. The reason for this is even with abnormally shaped semen there is still a chance that a male can get their partner pregnant, it just may take a little longer than usual.
If pregnancy still doesn't happen after the suggested waiting period, the doctor may offer various other treatments including looking into various fertility treatments. A couple does not to give up hope of naturally conceiving right away if you guys have gotten this far without getting pregnant. Instead you can try some of the following natural treatments that have great success rates in producing healthy semen by nourishing and revitalizing the male reproductive system.
Avoid Heat- Exposure to extreme temperatures, especially heat, can lead to abnormally shaped sperm. If you participate in activities that have the scrotum exposed to heat, if at all possible stop these activities for the time being. That means avoiding hot tubs, saunas, long-distance bicycling and wearing briefs. Once these activities are halted sperm morphology always decreases.
Eat Food that Support Sperm Health- Vitamin E, zinc and selenium are all nutritious additions to your diet that help boost hormonal and reproductive health in male patients. You can find these in tuna, beef, chicken, walnuts, eggs, Brazil nuts and cheese.
Dietary Supplements- If you think you aren't getting all the vitamins and minerals listed above into your diet at daily recommend amounts, consider fortifying your diets with dietary supplements. You can also add B12, folic acid, Vitamin C and L-Carntine to improve the health of your sperm. Make sure to take the right amount of supplements, because taking too much can cause harm to your body.
Take Antioxidants– Sperm morphology is caused by the DNA not making sperm correctly due to the decreased integrity of the DNA systems. To help increase DNA's ability to generate correctly formed sperm taking antioxidants can be useful. You can either take antioxidants in pill form, or fortify your diet with yogurt, berries, artichokes and other antioxidant rich foods.
Eliminate Environmental Toxins- Our body suffers from smoke, pesticides, chemicals, alcohol and cigarette smoke. These toxins are part of the reason our DNA can't function at full capacity. Try to eliminate these toxins to the best of your ability.
Participate in Activity to Cleanse Your Body of Toxins- Yoga, exercise, detox and acupuncture are all ways to help get the toxins out of your body. Even just drinking tea and cutting down sugar will assist your body of cleansing itself. Remember after performing any of these activities to drink a lot of water to help your body further cleanse itself of these nasty things in the body.
Todd B. Nippoldt, M.D. Male Fertility. Web MD.
How To Treat Abnormal Sperm Morphology Naturally. Natural Health for Fertility.


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Acting Reel
Welcome to MatthewMurumba.com
I'm a professional actor based out of Los Angeles and New York. I'm excited you've found the site and hope you enjoy poking around.
If you'd like to stay up to date on all of my projects don't forget to sign up for my mailing list under contacts and follow me on Facebook, Twitter, Instagram and Vimeo.
Show More
Recent Trailer - Don't Tell Larry
Recent Spot - New Balance
Photograph by Brian Parillo


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What Should I Do Following a Hit and Run?
- Posted on:
Hit and run accidents are, unfortunately, more common than you might think. When you're hit by another vehicle and the driver simply drives away, it can be frustrating. You may feel like nothing can be done, so you don't even bother to call the police if you can still drive your car. However, that's not the best idea. Here are some of the things you should do after a hit and run so you have a better chance of getting the compensation you deserve.
Write Down Any Information You Can
Once you've made certain that you're safe, write down as much as you can about the other vehicle. Do this quickly because you may forget important details, especially once you start talking to the police. One of the best things you can do is make notes on your phone. You can even start taking video and narrate what happened while capturing the accident scene. Important information you need includes the car's license plate, if possible, the make and model, the color, the location and the time, and which way the driver drove after leaving the scene.
You'll also want to get the contact information for any witnesses. Many times, people nearby will come forward to give you information about what they saw. Even if you missed the license plate number, one of these witnesses may have got it. Ask if they will provide information to the police and get their name, address, and phone number.
Call the Police
Next, get the police involved. Tell them what happened and that you want to file an accident report. If you're injured, call 911 so that you can also have the dispatcher send an ambulance to the scene. Provide the police with all of the information you've gathered.
File a Claim with Your Insurance
Call your insurance company and file a claim. If you're able to track down the driver, your insurance company can likely get the person's insurance information so you can file with their company. Many people who do hit and runs leave the scene because they are driving without insurance. To protect yourself against that, you may want to consider adding uninsured motorist coverage to your policy.
Were you in a hit and run? If you were and need assistance with the legal aspects of these accidents, Held & Hines LLP is here to help. Contact us today with the details of your accident.
Posted in: Car Accidents, Personal Injury, Uncategorized


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Gay students -- Pennsylvania
Subject Source: Library of Congress Subject Headings
Found in 3 Collections and/or Records:
Swarthmore Gay and Lesbian Alumni Network records
Collection — Box 1
Identifier: SFHL-RG6-R8-01
Overview In 1987, several alumni of Swarthmore College proposed to the Alumni Office the idea of forming a gay and lesbian alumni network. The network produced several issues of a newsletter, Out Together, before apparently becoming dormant. This collection includes copies of the newsletter, letters from alumni (often featuring memoirs of gay life at Swarthmore), and other materials used for the creation and production of the newsletter.
Dates: 1987 - 1989
Intercultural Center Records
Identifier: SFHL-RG6-Q030
Overview The Intercultural Center (IC) at Swarthmore College was founded in 1992 to promote systemic change toward a multicultural perspective across the institution and to foster community-building and collaboration among diverse groups within and outside of the college. The collection contains records relating to the founding of the IC and its activiites, as well as records that detail the activities of groups within the IC, specfically HOLA (Hispanics Organized for Latino Awareness/Hispanic...
Dates: 1988 - 2017
Swarthmore College Sager Committee records
Identifier: SFHL-RG6-P004
Overview The Sager Symposium is an annual conference at Swarthmore College focusing on different issues relevant to the LGBTQ community. The first Sager Symposium was held in 1989. The collection contains records of the Sager Committee and event-related materials, 1988-2002.
Dates: 1988-2002


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In an exclusive this morning, Hollywood Reporter writes that actress Gong Li will be joining the cast of Disney's live-action Mulan and martial arts expert turned actor, Jet Li is final talks for a role in the film. This exclusive follows yesterday's announcement that Rogue One's Donnie Yen has joined the cast as Commander Tung. According to THR, Gong Li will play a powerful witch as the film's main villain—a completely new take from the animated version's Hun leader, Shan Yu,—with Jet Li in final talks to play the Emperor.
The film will be directed by Niki Caro and is set to release on March 27, 2020.


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Worship Sunday at 10:30
Bethany Evangelical
|Northern Great Lakes Synod † Evangelical Lutheran Church in America † Bethany on Facebook
Pentecost 08/26/2012
The words are familiar, "Lord, to whom shall we go? You have the words of eternal life." It's what we say before the gospel is read most weeks of the year and this text today provides the context for those words because, as is the case with most of the liturgy, it's all in the Bible somewhere. Now when we make this acclamation each week it's intended as a confident statement of faith as we stand and welcome Jesus into our gathering with the words of the gospel. In the biblical context however, that confidence is less clear because we don't really know what tone in intended. Is it an expression of bold and confident faith on the part of Peter, or is it kind of a shrugged resignation, "I don't really know who you are or what you're talking about Lord, but what choice do I have? It's too late to stop now."
This conversation between Jesus and the disciples ends the bread of life discourse we've heard for the past five weeks and like the rest of the chapter, like much of John's gospel actually, a lot of it is nice to listen to, quite poetic, but a lot of it is difficult too, vague and not so easy to figure out, downright confusing sometimes. There is much to be interpreted but one thing that seems quite likely is that similar to many gospel texts, this one may tell us more about what was going on at the time it was written than it tells us about what was going on between Jesus and his disciples.
The general consensus is that John is the latest of the gospels, not written until the year 90 or so, some 60 years after the death and resurrection of Jesus, maybe 20 or 25 years after the other gospels. In that amount of time a lot had happened among the followers of Jesus, a lot of reflection had taken place. So, besides recounting and retelling some of the events of Jesus' life, John's gospel also represents significant interpretation about Jesus. It gives us what many had come to believe about him, specifically that he was the bread of life, the Son of the God he called Father, that he was the Holy One of God as Peter says in this text today. Those are all strong statements of faith and when the early church councils discussed and decided what constituted correct Christian belief, they drew heavily from statements like this from John; that's why the tradition calls John "the theologian."
What the end of this chapter shows though, is that if Jesus was controversial while he was still around, some of the faith statements about him during the post-resurrection years were maybe even more controversial. The indication we get from this text today is that at the time it was written, again, around the year 90 or so, even some who had been attracted to Jesus and the teachings about him and had followed for awhile were falling away because, "This teaching is difficult, who can accept it?" As a result, what we apparently have described in John is a church in decline, people drifting away. Does that sound familiar? It's something that we can certainly relate to and the reason for the decline wasn't all that different then from what it is now. For a skeptical world, the teachings about Jesus have always been difficult.
Yet, some of us continue to say, "Lord, to whom shall we go? You have the words of eternal life," but we could ask ourselves the same question we posed for Peter: is it a bold statement of faith on our part, or is it more a statement of resignation, of not knowing what else to do, or maybe it's different on different days depending on how we feel. In some ways it doesn't matter because however we say it, it acknowledges that Jesus is at the center of our version of reality, a sub-version of reality as Walter Brueggemann calls it because faith in the God of the Bible, called YHWH, the Lord in the Old Testament and revealed in Jesus in the New, faith in this God is no longer the dominant version of reality; it is a sub-version.
We live during a time when to view life without any reference whatsoever to God is perfectly credible, you know that. You also know that there was a time when that wasn't the case, belief in God was a given. But now, to view life with God as the main character is seen by many as in-credible, something belonging to superstition of the past that we modern people should let go of. We live in a rational world that demands the certainty of scientific proof which, regarding our faith, we can't offer, so to say, "Lord, to whom shall we go?" or to make any other statement of faith is not as easy as it once was, in fact it can even be a little embarrassing. It's one of the reasons that many do turn away because the teaching is difficult, who can accept it?
Yet some of us do accept it. We continue to say, "Lord, to whom shall we go?" because for us, the many other available alternatives don't satisfy. We want more than what a cold, unimaginative, matter of fact world can offer and we find that in the version of the world that Jesus offers. It doesn't mean we understand it all; it doesn't mean we don't have questions but somehow this character of Jesus draws us, his words, his teachings, the images of him as the bread of life, the good shepherd, living water, they comfort us, they compel us, sometimes they challenge us, but we keep coming back. Lord, to whom shall we go? With Jesus at the center, we imagine the world differently and we find that we can't imagine the world without him at the center.
In the years I've been doing this, in the years I've been a pastor, one of things I've heard many times from people going through difficult times is, "Pastor, I don't know how people without faith deal with these things." It's interesting too, because in many cases it's been said when you could say that prayers haven't been answered. Someone has died or healing isn't happening and doesn't seem likely, things like that. But it's at those times that some people, in confidence or in resignation whatever it is, will say, "Lord, to whom shall we go?"
For them Jesus is more than a superhero god who is at your beck and call just waiting to fix everything. Sooner or later that Jesus will let you down because it's not that simple. The God of the Bible is not a vending machine where you put your request in, push the button and out comes what you're looking for. We think we'd like that, but I'm not so sure. In any case, that's not the God or the world we deal with. Jesus came to this world, not some make believe, fantasy land world where nothing bad ever happens, nobody dies and everything works out just the way you want. He came to this world and entered its reality, as messy as that can be. He entered the brokenness and death of this world and by doing that, he changed it. He brought life and hope to situations that seemed to be without it.
That's a different version and different vision of life. It doesn't deny the reality of this world including the bad things that happen, but it's a version, a sub-version that doesn't end there but which always ends in hope. And it's hope that doesn't lie in our ability to fix things, it lies in the resurrected Jesus who embodies new life and hope. In and through the cross and resurrection, he has created a new reality and when we proclaim, "Lord, to whom shall we go?" it's that resurrection reality and hope that we hang on to because the other possibilities, the other versions of reality, as seductive as they can be, all end not just in death, but in hopeless death.
"Lord, to whom shall we go? You have the words of eternal life." We keep saying it, week after week and saying it is important. Like I said last week, the words we say form us. It's an important reminder of our sub-version of reality, a reminder that another world is possible as we keep saying it and imagining it. Saying it and imagining it we also enact it. We are obedient to the words we proclaim, the words of Jesus. We become people of hospitality, of sharing and giving, compassion and caring, of forgiveness and new opportunities. It's a sub-version, but it's our version; more importantly it's Jesus' version, so we keep saying it, we keep living it.
Some will fall away and pursue other realities, they always have, some but not all. So week after week we'll still be here, announcing and living the reality revealed in Jesus. Our numbers may not be huge but they're enough. We'll still be here, because, "Lord, to whom shall we go?"
Rev. Warren Geier
Website designed and maintained by Superior Book Productions


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Today was the first day of Reading Week! It started after my morning class, which was Communication Design 2, where I pitched my ideas for the final part of my assignment! (its going to be a calendar btw). So now, I am up at the cottage with my family, just relaxing and taking time off working.
Not entirely actually.
Right now, I am just making some art for myself, while I have the chance anyway. So, I decided to make myself my very own "Breakfast At Tiffany's" poster! Granted, I do have a copy of one that I bought at the MoMA last May, but I want to actually MAKE one!
Here is what it looks like right now:
Leave a comment if you have any suggestions for what I should add, exclude, change, anything you think.
I'm open to any feedback 🙂


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Brokerage Industry Rallies Employees to Push for DOL Rule Delay
With just 14 days to comment on the Department of Labor's proposal to delay implementation of its fiduciary rule by 60 days, brokerage firms are rallying employees to communicate their views in favor of a delay.
LPL Financial on Tuesday sent its 14,100 affiliated independent brokers an "Action Requested: Ask the DOL to Finalize the 60-Day Delay" notice as part of a campaign coordinated with the Securities Industry and Financial Markets Association, the industry's major trade group.
"In response to last week's activity, the [government relations] team partnered with SIFMA to quickly develop a portal that enables you to engage in this comment period and ensure that our views on this issue are heard," Andy Kalbaugh, LPL's divisional sales director, wrote, referring to last Thursday's publication by the DOL of its request for comment.
He directed brokers to a webpage with this suggested comment language: "As a licensed financial professional serving the retirement and investment needs of my clients, I ask you to take the necessary steps to finalize the 60-day delay of the Department of Labor fiduciary rule….With so much at stake for investors, I strongly encourage our policymakers to finalize this proposed 60-day delay so that we can all take the necessary time and work towards the best resolution possible."
As of Wednesday morning, not quite a week after the proposal was published in the Federal Register, the DOL had posted 215 comments. While commenters identifying themselves as advisors are decidedly in favor of a delay, consumer groups and some registered investment advisors and robo-advisors urged implementation on the original April 10 date and warded off suggestions that the industry needs more time.
"We believe that any delay would needlessly perpetuate conflicted advice at investors' expense," wrote Jon Stein, founder and chief executive of Betterment, a broker-dealer that sells "robo" management services directly to investors and through RIAs.
Ladenburg Thalmann Financial Services, an independent broker-dealer in Miami, Fla., said sticking to the original date will hurt investors because the asset-management industry is not ready with DOL rule-compliant products to offer clients on its platform.
"Ladenburg will be forced to significantly reduce retirement products available to investors," Doug Baxley, vice president of retirement and fiduciary services, wrote. "This is because product sponsors simply have not had the time necessary to modify their products to meet this requirement."
Scott Eichler, an RIA at Newport Wealth Advisors in Newport Beach, Calif. that also offers brokerage products through Centaurus Financial, Inc., went further in his personalized comment. "My job entails squeezing every drop of return I possibly can from the risk tolerance that the family [sic] I am serving will accept. To that end, the more tools I have, the more needs I can serve….I would implore the DOL to delay this implementation date."
While the letter-writing campaign is aimed at the near-term start debate, some commenters also flicked at the more fundamental review of the rule's costs and benefits that President Trump last month ordered the Labor Department to undertake.
"Looking beyond the delay of the applicability date, we urge the Department to maintain strong protections to ensure that all Americans have access to unconflicted investment advice," Christopher Jones, chief investment officer of Financial Engines wrote in support of moving ahead with the current dates. The California-based RIA manages about $138 billion in employee retirement assets through 401(k) and other programs.
Bart Naylor, a financial policy advocate at Public Citizen, said his organization plans to work with other consumer groups to encourage members to comment.
The comment period extends until March 17. If the DOL proceeds with its conflict-of-interest rule implementation delay, firms will not be required to abide by it until June 9. The DOL is concurrently proceeding with a 60-day comment period on whether it should go further and modify or eliminate the rule.
Dang, LPL corporate must have the same email list I have!


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Anyway, T Rex went electric/glam in 1970 with them "T Rex", coupling glitter/glam riff rock with almost eqully nonsensical lyrics, and became popular almost immediatley, more so in the UK than here though.
T Rex is not really a great album, but it IS a corner stone in the UK glitter/glam scene of the early 1970's....short tracks which still carry forward plenty of thier silly folky/psych pretensions: "The Children of Rarn".
, "The Wizard"..NOT a classic, but then......1971's "Electric Warrior" IS a "classic", a "classic" of super stupid electro-glam-riff-rock, featuring of course the legend that is "Get It On (Bang a Gong) with it's remarkable lyrical complexities, not to mention lesser known treasures such as "Rip Off", "Jeepster", and "Cosmic Dancer"....it is almost impossible to listen to this with a straight face, a period piece of almost embarassing hilarity......myself, I LOVE it!
Even better for my money, though not quite as popular was "The Slider".....this thing is a masterpiece of "stupid-rock", almost every tune a "classic: when we look at it in that light.....where to begin? "Metal Guru" which was a huge hit in the UK and contians the lyric "Metal Guru is it you?", my younger brother at the time interpereted it as "Metal Guru is a Jew".......there is a LOT more, the title track, "Rock On", "Ballrooms Of Mars", "Spaceball Riccochet", and especialy my fave the rockin "Buick Mackane".......simply cannot give this 5 stars, even though it is "perfect" for what it sets out to do, lets go four stars and all be happy.....
A short run really, the follow up "Tanx". really sucks the big 'un, they try to regain the innocent stupidity of "The Slider" with poor results....really stuff like "Tenement Lady", "mad Donna", and the noxious "Born to Boogie" could have been outtakes from "Electric Warrior" or "The Slider"......this was one bus ride that had reached the last stop. "Zinc Alloy and the Hidden Riders of Tomorrow" is even worse, presented here for the comdy factor alone. Same goes for "Bolan's Zip Gun", an atempt yet, to go (lord) "in other musical directions".....there's a reasn you likely haven't heard it, trust me.
Since I'm feeling evil, and to ensure that "Anonymous" feels I have done enough to promote the "Gay Agenda", I have a couple comps here, including the FOUR disc "20th Century Superstar Series" which has more shit on it than the most rabid T Rex fan could clamour for, ALL KINDSA SHIT here, from the "Ride a White Swan" era and lots more!
Do have a live album or 2 here, "Live at the BBC 1970-71" captures them at their glammy best, and a rare boot from 1977, although they had had the fork stuck in em by now, is of interest.......T Rex are an important part of early 1970's glam rock, imagine should they come out today, they'd be laughed back to the but they sounded good at the time, and Marc Bolan had the right look for the right time.....it was fun while it lasted! One last note, I think Bolan was once quoted as saying "NOTHING in my career has been an accident!", prior to being killed in, well, an automobile accident........sweet irony I guess.......
I am not about to search out all their folkie albums, here are the 1970's glitter/glam hard rocking albums, hope you enjoy them as much as yer pervered uncle does!
By the way, I think Dave Sez and Julian have made amends, at least I hope so......it was a misunderstanding, and you guys are BOTH valuable contributors to this site, I'd HATE like hell to lose either of you......as for ol' "Anonymous", he has me figgered out I'm afreard: I posted sexy pictures of Erin Andrews to throw you guys off the track, because my TRUE plan here is to promote/support the gay agenda which he hilariously lays out in one of his comments (truth is, I just like Erin Andrew's ass).....he says he's leaving this "gay blog' forever, I personally say don't let the door hit you on the way out, please, please, GO AWAY FOREVER!
One minion had a good idea though....if Dave Sez (or anyone) wants the "keys' to this blog, they are welcome......write your own stuff, post it yourself, and some day I'll wake up and say "DAMN I don't hav to do SHIT today!"......any serious contributors who would LIKE to have the blog keys, contact me at email@example.com and we can certainly talk, I like the idea!
T REX-01 The Children of Rarn/02 Jewel/03 The Visit/04 Childe/05 The Time Of Love Is Now/06 Diamond Meadows/07 Root of Star/08 Beltane Walk/09 Is It Love?/10 One Inch Rock/11 Summer Deep/12 Seagull Woman/13 Suneye/14 The Wizard/15 The Children of Rarn (Reprise)
ELECTRIC WARRIOR-01 Mambo Sun/02 Cosmic Dancer/03 Jeepster/04 Monolith/05 Lean Woman Blues/06 Bang a Gong (Get It On)/07 Planet Queen/08 Girl/09 The Motivator/10 Life's a Gas/11 Rip Off
THE SLIDER-01 Metal Guru/02 Mystic Lady/03 Rock On/04 Slider/05 Baby Boomerang/06 Spaceball Rocochet/07 Buick Mackane/08 Telegram Sam/09 Rabbit Fighter/10 Baby Strange/11Ballrooms of Mars/12 Chariot Choogle/13 Main Man/14 Cadillac (Extended)/15 Thunderwing (Extended)/16 Lady (Extended)
TANX-01 Tenement Lady/02 Rapids/03 Mister Mister/04 Broken Hearted Blues/05 Shock Rock/06 Country Honey/07 Electric Sam and the Factory Hen/08 Mad Donna/09 Born Boogie/10 Life Is Strange/11 The Street and Babe Shadow/12 Highway Knees/13 Left Hand Luke and the Beggar Boys/14 Children of the Revolution/15 Jitterbug Love/16 Sunken Rags/17Solid Gold Easy Action/18 Xmas Riff/19 20th Century Boy/20 Free Angel
ZINC ALLOY AND THE HIDDEN RIDERS OF TOMORROW-01Venus Loon/02 Sound Pit/03 Explosive Mouth/04 Galaxy/05 Change/06 Nameless Wildness/07 Teenage Dream/08Liquid Gang/09 Carlisle Smith & the Old One/10 You'v Got to Jive To Stay Alive-Spanish Midnight/11 Interstellar Soul/12 Painless Persuassion vs the Meathawk Immaculate/13 The Avengers (Superbad)/14 The Leopards Featuring Gardenia and the Mighty Slug
BOLAN'S ZIP GUN-01 Light Of Love/02 Solid Baby/03 Percious Star/04 Token of My Love/05 Space Boss/06 Think Zinc/07 Till Dawn/08 Girl In the Thunderbolt Suit/09 I Really Love You Babe (Prescision Debating)/10 Golden Belt/11 Zip Gun Boogie (Live)/12 Do You Wanna Dance/13 Dock of the Bay/14 Solid Baby/15 Till Dawn (Marc's Guide)/16 Tll Dawn/17 Till Dawn/18 Girl In the THunderbolt Suit (Bluejean Bop)/19 Dishing Fish Wop (Golden Belt)
LIVE AT THE BBC-01 Hot Rod Mama/02 Deora/03 Pavillions of the Sun/04 Dove/05 By the Light of the Magical Moon/06 Elemental Child/07 The Wizard/08 Ride a White Swan/09 Summertime Blues/10 Jeepster/11 Cadillac
MARC BOLAN & T REX DISC 1-01 The Road I'm On (Gloria)/02 Blowin in the Wind/03 The Wizard/04 Beyond the Risin' Sun/05 The Third Degree/06 San Francisco Poet/07 Eastern Spell/08 Hippie Gumbo/09 Misfit/10 Jasper C DeBussey/11 Desdemona/12 Midsummer Night's Scene/13 Sara Crazy Child/14 The Lilac Left Hand of Menthol Dan/15 Sleepy Maurice/16 Highways (Alias Misty Dust)/17 Child Star/18 Chateau In Virginia Waters/19 Puckish Pan/20 Lunacy's Back/21Debora/22 Hot Rod Mama/23 Scenscof/24 One Inch Rock/25 Salamanda Pal/26 Consuela/27 Juniper Section/28 Nickelodeon/29 Pewter Suitor/30 The Seal of the Seasons/31 Catblack (the Wizard's hat)/32 Chariots of Silk/33 Iscariot
MARC BOLAN T REX DISC 2-01 King of the Rumbling Spires/02 Do You Remember ALternate Vocal)/03 Do You Remember/04 Once Upon the Seas of Absinniya/05 Ill Starred Man/06 Demon Queen/07 By the Light/08 Lofty Skies/09 Elemental Child/10 Dove/11 The Prettiest Star/12 Oh Baby/13 Ride a White Swan (Intro)/14 Ride a White Swan/15 Ride a White Swan (Outro)/16 Untitled Poem/17 Jewel/18 Diamond Meadows/19 Beltayne Walk/20 Suneye/21 Childe/22 The Children of the Rarn/23 Hot Love/24 King of the Mountain Cometh/25 Mambo Sun/26 Cosmic Dancer/27 Get It On/28 There Was a Time -Raw Ramp/29 Rip Off
MARC BOLAN AND T REX DISC 3-01 Jeepster/02 Life's a Gas/03 Sailors of the Highway/04 Telegram Sam/05 Cadillac/06 Baby Strange/07 Metal Guru/08 Thunderwing/09 Spaceball Ricochet/10 Children of the Revolution/11 Jitterbug Love/12 Xmas Flexi Message/13 Solid Gold Easy Action/14 Born To Boogie/15 20th Century Boy/16 Highway Knees/17Electric Slim and the Factory Hen/18 Left Hand Luke and the Beggar Boys/19 The Groover/20 Blackjack/21 Truck On (Tyke)/22 City Port/23 Teenage Dream
MARC BOLAN & T REX DISC 4-01 Venus Loon/02 Painless Persuassion vs the Meathook Emmaculate/03 Change/04 Till Dawn/05 Light Of Love/06 Zip Gun Boogie/07Think Zinc/08 Solid Baby/09 New York City/10 Chrome Sitar/11 Dreamy Lady/12 Christmas Bop/13 Jupiter Liar/14 Dawn Storm/15 London Boys/16 I Love to Boogie/17 Laser Love/18 Life's an Elevator/19 To Know Him Is To Love Him/20 Teen Riot Structure/21 The Soul of My Suit/22 Dandy In the Underworld/23 Celebrate Summer
LIVE LONDON 3/18/77-01 Jeepster/02 Visions of Domino/03 New York City/04 Soul of My Suit/05 Groove a Little/06 Telegram Sam/07 Hang Ups/08 Debora/09 I Love to Boogie/10 Teen Riot Structure/11 Dandy In the Underworld/12 Hot Love/13 Get It On (With the Damned)/14 Jeepster (bonus)/
LIVE LONDON 3/18/77 DISC 2-01Telegram Sam (Bonus)/02 Token of My Lov (Bonus)/03 Teenage Dream (Bonus)/04 Zip Gun Boogie (Bonus)


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UK Government releases Clean Maritime Plan, setting maritime zero-emission travel strategy
The UK Government has announced today (Thursday 11 July) that all new vessels for UK waters ordered from 2025 should be designed with zero-emission capable technologies, in ambitious plans set out by Maritime Minister, Nusrat Ghani, to cut pollution from the country's maritime sector.
The Clean Maritime Plan is part of the Government's Clean Air Strategy, which aims to cut down air pollution across all sectors to protect public health and the environment. It will also help deliver the UK's commitment to be net zero on greenhouse gases by 2050. The Plan is also part of the Government's Maritime 2050 strategy which was published in January 2019.
The Plan also includes a £1 million competition to find innovative ways to reduce maritime emissions and is published alongside a call for evidence to reduce emissions on UK waterways and domestic vessels.
Maritime Minister, Nusrat Ghani, stated: "Our maritime sector is vital to the success of the UK's economy, but it must do everything it can to reduce emissions, improve air quality and tackle climate change.
"The Clean Maritime Plan sets an ambitious vision for the sector and opens up exciting opportunities for innovation. It will help make the UK a global hub for new green technologies in the maritime sector."
The Government is also looking at ways to incentivise the transition to zero-emission shipping and will consult on this next year.
A further consultation to increase the uptake of low carbon fuels will also take place next year.
The full Clean Maritime Plan can be read here.
British Marine is partnering with the Department for Transport on the call for evidence on Domestic Shipping Air Pollution which was released today (11 July 2019). Over the next six months, British Marine will be calling upon members to help provide evidence from across the leisure, superyacht and small commercial marine sector. It will publish more details on how members can get involved in next week's Latest News.
For more information contact Brian Clark on email@example.com
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Dates: June 19 – 25, 2021
Location: Nashville, Tennessee
Early Bird Registration Tuition Discount
Any student enrolling and paying in full prior to February 15, 2021, will be afforded a discounted tuition of $2,295
Regular Registration Tuition
After February 15, 2021, tuition will be $2795
Registration Payment Deadline
May 15, 2021
You may reserve a place at WLI by paying a $695 deposit at any time prior to February 15, 2021 registration deadline. The balance of the tuition is then due by May 15, 2021.
Cost of Registration Includes:
Tuition, refreshment breaks, notebook and materials, professional coaching, several lunches and dinners, admission into the WLI FB group, a voice class and the formal banquet.
Cost of Registration Does NOT Include:
Hotel, travel, any meals not provided by the event, rental car, or any unexpected expenses. We will have a recommended hotel that we encourage attendees to stay at to facilitate access to coaches, camaraderie with your teams, and coordinating transportation.
Early Deposit and Payment Bonuses
Students who submit the $695 deposit on or before October 15, 2020 will be eligible to receive a bonus of six Praise And Harmony Training DVDs of your choice. Students paying registration fees in full prior to December 15, 2020 will not only receive the Early Deposit Bonus and the Early Bird rate, but will also receive all of the Praise & Harmony worship powerpoint slides (valued up to $825 for any albums you do not already own – no exchanges or substitutions.) You will receive your slides or DVDs at the conclusion of WLI. Early Deposit or Payment Bonuses will not apply to scholarship recipients.
Group Discount
Up to three (3) students from the same church can receive a $100 discount off each tuition. Four (4) or more students from the same church will receive a $200 discount each.
Refund Policy
Any student withdrawing before February 15, 2021 will receive a full refund. On and after February 15, you will forfeit the $695.00 deposit amount. ALL CANCELLATIONS MUST BE IN WRITING (can include notification by email).
Wait List
When the WLI reservations are full, students may be added to a waiting list by submitting an application. Admittance will be prioritized on a first come, first served basis. When you are notified by email with an invoice for payment, you will be guaranteed a spot in WLI.
For more information, contact:
Bill Brunkhardt
Phone: 615-681-7105
Email: email@example.com


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Chess team wins first at Concordia tournament
The chess team won first place at their tournament in Concordia on Saturday, Feb. 9.
There were four teams in all participating in the tournament.
The team's win was the first championship win in club history.
"We were pretty excited," Sophomore Mataya Quinby said.
The team was split into Team A and Team B for the tournament. Team A won first, and Team B won third. However, they allowed their third place go to a different school due to the school not placing during the tournament.
Individually, all students from Hays High placed. Nick Zimmerman placed second, Japeth Briney third, Zacherian Miller sixth, Trevor Mai ninth, Jon Garner tenth, Benton McGrath fourteenth, Cody Conger seventeenth, and Mataya Quinby nineteenth. Nick Newell also attended the tournament, but got sick and had to forfeit the last rounds.
During a tournament, the participants are brought to a room where tables and clocks are set up. There are about six games every tournament for each division. Each division goes in the room and plays, having no new games start until every game is complete.
"There is typically no talking at all in the room where the playing goes on," Quinby said, "You shake hands, play, tell the people at the front which table you were at and who won, and then you leave that room."
Each game has a time limit of 30 minutes, but each time a player presses for the next person to play their turn, they get a five second delay. This delay is so the players have time to write down what piece they moved and where they moved it to. They also write down the moves their opponent makes.
"My favorite part was having fun with the people I was with," Quinby said, "They are very fun, nice, funny, and welcoming people."
Quinby said this tournament was the first one she's been to, but she's planning on going to the next tournament and then on to state.
"The next tournament will be on March second at Canton-Galva, Galva Kansas," Quinby said.
McKena McBride is a junior, and this is her second year in Newspaper. She is involved in tennis, track, StuCo, Red Cross Club, Future Medical Professionals...


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Willamette Valley WineView all products in Willamette Valley Wine
The Willamette Valley Viticultural Area, located in the Willamette Valley of Oregon. AVA is the largest of Oregon and contains most of the wineries in the state.
This region was founded in 1984 and since then there have been a total of 6 new smaller AVA located in the northern Willamette Valley. The Willamette Valley has a cool, wet weather and is recognized worldwide for its Pinot Noir.
Experts in the wine world Willamette divide the territory in the north and south.
Willamette Valley has over 200 wineries with the greatest concentration of them west of the Willamette River in Yamhill County.
Within grapes grown in this AVA are the Cabernet Franc, Cabernet Sauvignon, Cascade, Chardonnay, Dolcetto, Early Muscat, Muscat Canelli, Pinot Blanc, Pinot Gris, Pinot Noir, Riesling and Sauvignon Blanc, to name the main ones.
Buy Willamette Valley Wines online.


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Michaël Borremans: Sixteen Dances
The title of Michaël Borremans' sixth solo exhibition at Zeno X makes reference to dance as a metaphor for the painter's practice and to the different positions that the medium can adopt with regard to society's current pulse. The inherent ambiguity immediately sets the tone for the substantive character of the themes on display. The works demonstrate a sense of playfulness, eagerness and virtuosity. At the same time, Borremans' recent work has a dark side. The monochrome backgrounds provide little explanation about the situations in which the peculiar characters find themselves. A particular atmosphere in which time and space seem indeterminate incites viewers to reflect on the overall meaning. 'Sixteen Dances' is composed of three themes and also occupies the gallery's back room, furnished as a study.
'Fire from the Sun', one of the themes, depicts naked toddlers and young children who seem to have ended up in a strange ritual. It is unclear whether they have been smeared with paint or blood, but there is an unmistakable hint of cannibalism. The works combine horror and innocence in the shape of children. 'Fire from the Sun' refers to natural primal forces but also to human urges and humanity's animal nature.
A second series shows athletic black men whose faces are completely covered. The artist asked young hip-hoppers to dance to what for them is unconventional music: 1950s rock 'n' roll. The gold chains and sagging trousers hint at their identity but at the same time give the scene an absurd and anachronistic feel. In addition, the titles also refer to the language and slang of the world of hip-hop: 'Fugazy', 'On the Grind', 'Buggin' or 'Phat'.
The last group of works features figures in shiny, close-fitting suits. As in the earlier series, 'Black Mould' (2015), in which characters are dressed in black garments, there is something oppressive and threatening about this series. The fact that they are entirely covered and therefore dressed anonymously heightens the feeling of theatricality and artificiality; they come across as extras in a disturbingly bare setting.
The artist's tendency to work more regularly in series comes from his longing to go deeper. At the same time, a cinematic continuum is suggested from which random stills are made. However, it remains unclear to viewers whether there really is a narrative structure in which one work follows on from the other.
The ambiguous and strained atmosphere enveloping the works refers to the widespread feeling of disorientation that permeates our current age and society. This approach can seem highly contemporary but is in fact an age-old theme in the field of art history. Borremans here likes to refer to Goya, Bosch and Bruegel. He questions human nature and takes a close look at the current conception of humanity. 'Sixteen Dances' ushers the unsettling state of the world into the gallery but sends the visitor back out with an intense feeling which has already been indirectly permeated by dance.
His retrospective 'As sweet as it gets' travelled in 2014-2015 from Bozar in Brussels to the Tel Aviv Museum of Contemporary Art and the Dallas Museum of Art. The exhibition 'Eating the Beard' opened at the Kunstnernes Hus in Oslo before being shown at Kunstverein Stuttgart, Kunsthalle Budapest and Kunsthalle Helsinki. Michaël Borremans has also had solo exhibitions at CAC Malaga, the Hara Museum in Tokyo, MCA Denver, Kestner Gesellschaft in Hannover, De Appel Arts Centre in Amsterdam, The Cleveland Museum of Art, Parasol Unit in London, S.M.A.K. in Ghent, Museum für Gegenwartskunst in Basel, Kunsthalle Bremerhaven and many more.
In 2018 Borremans will take part in the Sydney Biennial and he will inaugurate the new space of David Zwirner in Hong Kong.


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Road Choice redesigns Web site
GREENSBORO, N.C. — Road Choice has launched a new Web site for its parts line.
The new site, found at www.RoadChoice.com, is more powerful, functional and allows for easier parts lookup, according to the company. It also features a more user-friendly responsive design.
"When we launched the Road Choice Truck Parts line, the Web site provided the needed information, but we wanted to improve the look and feel and the functionality for our customers," said Dan Bambrick, Road Choice private brand manager. "We are pleased, not only by the enhanced experience, but also by the fact that this version maintains an attractive look, regardless of how you choose to view it."
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Last night I cancelled my Blockbuster Online account and returned to the Netflix fold. It just goes to show that it doesn't always come down to price when it comes to deciding between competing services and that good design really does make a difference.
Real Life
iTunes 4.9: Podcasting Software for the Masses
Thanks to Apple and iTunes 4.9 I've finally got the whole podcasting thing. As I was cycling to work this morning listening to a podcast of one of my favorite shows – NPR's "On The Media" – it dawned on me at last what a cool technology podcasting is. Read More
Interior Painting Tips
I just finished painting our bedroom. We were going to pay a professional to do it, but then decided that we'd save the $400 and do it ourselves.
And you know, it wasn't too much of a chore; mainly because of these painting tips that I picked from a friend who's in the business.
Musical Baton
Thanks, Derek, for passing me the musical baton.
So, here's mine:
Cruise Tips for First Time Travelers
I recently returned from my first cruise (on the Holland America ship the ms Oosterdam) from San Diego down to the Mexican Riviera.
Being new to the whole cruise experience I didn't really know what to expect, but now that I have that first trip under my belt, there are a few tips I wish I'd known beforehand that I thought I'd share for the benefit of anyone else about to embark on their maiden voyage.
My Number One Dating Tip For Men
Now that I'm married, I no longer have any use for this dating tip, but it's such a good one it seems a shame not to share it. Read More
A Good Source of Web Design Gigs
The hardest thing for anyone starting out in the web design business is to actually get any business in the first place. Read More


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Nowhere to Run is episode three of the first season of Murphy Brown, that originally aired from CBS on November 28, 1988.
Plot Edit
Murphy investigates a federal prosecutor who's linked to mob-run prostitution. Miles fears for his life when he receives his first death threat.
Cast and Characters Edit
Main Edit
- Candice Bergen as Murphy Brown
- Faith Ford as Corky Sherwood
- Grant Shaud as Miles Silverberg
- Joe Regalbuto as Frank Fontana
- Robert Pastorelli as Eldin Bernecky
- Charles Kimbrough as Jim Dial
- Pat Corley as Phil
Guest Edit
- Ritch Brinkley as Carl Wishnitski
- Michael Gregory as Tiffany Howard
- Lily Mariye as Secretary #6
- Tom McCleister as Stagehand
- Fran Ryan as The Asp
- Ebbe Roe Smith as Man At Table
- Myra Turley as Secretary #7
Trivia Edit
- The title is based on the 1965 song "Nowhere to Run" by Martha & the Vandellas for Motown Records.
Quotes Edit
Community content is available under CC-BY-SA unless otherwise noted.


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A French police officer was charged with Rape of a victim by the name of THEO. Theo was a victim of police brutality in the city of Paris. He was handcuffed, pepper-sprayed and anally raped with a truncheon for no apparent reason. Part of the stop and frisk program, Theo became a victim of the vicious, sadistic, psychotic, racist behavior of corrupt police officers. The officers attempted to lie about the incident and state the rape did not happened even-though video footage shows otherwise. French Government initially backed up the officers until evidence came out. Theo was rushed to the hospital for emergency surgery of his anus. Police admitted it was "UNINTENTIONAL." Theo is currently at the hospital. Disgraceful French President Francois Hollande visited the young victim to make attempts to calm the situation down. So far protesters are in full force and riots has started in the name of Theo. Theo is 22 years old, employed, and has NO CRIMINAL RECORD. This an example of corrupt police officers abusing their power for their BDSM fetishes. How can the Police Unions expect citizens to RESPECT their authority yet they ignore or refuse to ROOT out corrupt officers within their ranks? If you have unstable, evil, racist, sexist, sadistic, officers in your ranks, they NEED to be FIRED. We the taxpayers pay their salaries and pensions. I do believe officers need to be treated with respect as long as the feeling is mutual towards the citizens. I pray Theo recovers and SUES the Paris police department, and the French Government for liability. How can some of you anti-black lives matter groups label the organization as terrorist groups or agitators. They exist because corrupt cops exist. Yes BLM has ulterior motives and they are owned by George Soros, but SOME member of BLM are about justice and respect of the law. We cannot turn a blind eye on police brutality and normalize it. Unfortunate GOOD cops get to be taken down by bullets meant for the CORRUPT ones.
Tag: Police Brutality
NYPD Beatdown – Police Brutality Episode 2
Another NYPD beating caught on camera.
The Last Moment of Eric Garner
Eric Garner
43 Year old father of six children Eric Garner was put to death by Satan Island Finest NYPD yesterday. Garner was accused by the police of selling untaxed cigarettes on a corner. Garner broke up a fight earlier which sent in the police. Garner was pleading his case that he was minding his business. Police did not buy into it. The UN-trained police placed Garner in a choke-hold even-though Garner did not resist. 9 Cops slammed Garner to the ground and sat on top of his neck until he went into a cardiac arrest and died on the concrete. Video was shot by a local neighbor . This is POLICE BRUTALITY. Where are those so-called TOUGH GUYS on YouTube and Facebook whoa make daily death threats?
I will be on blogtalkradio TONIGHT 8:00PM CT to discuss this shocking horrific murder.
Call In : (347) 637-1668


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- Username
Creed Metatronis Hellgaia
- ...
Eden was not created by God, instead she was the sister of God Father of light and Yjarl, father of the endless abyss. She was the mother of all life except for the angels, who were God's guardians of light, and the Wraith, Yjarl's guardians of the abyss. God had created light so that he could show his sister Eden it's glory, she created many kinds of life within this light, but like any creation, both life, and light could no longer be controlled once let loose. Jealous of life and light, the Abyss bore Sin and death, for nothing could ever be truly perfect, and must always have an opposite to balance it. Because the light brought forth things that would hurt his dear sister Eden, Yjarl sought to extinguish his brother God's light in order to make her safe again. To this end, he must not simply destroy God's creations, but Eden's as well. Thus an eternal conflict begun, born from the misguided love of ancient, immortal beings, a maelstrom that engulfed all of creation.
Thus Eden bore a second son, her first being Adam, named Mythias Metatronis Hellgaia, Father of the Eden seeds, beings of immense power born directly from Eden in order to protect her. Eden loved all of her creations, including man, though not all of them would be fit to live in Eden's Crossing. To this end, she charged Adam with the protection of human kind, as he was their alpha while she charged Mythias, and the Eden Seeds that were his children with her own protection from the forces of her two brothers. Adam would guard over her beloved humanity while her Eden Seeds would make sure that her brother's didn't destroy everything she'd come to love with their petty, eternal war.
In preparation for this eternal conflict, Mythias created a city around his mother Eden. He called it Eden's Crossing, it's main purpose being to guard her so that no one would ever be able to hurt her, neither God, nor Yjarl. It existed nowhere, and everywhere at once. Soon, others found their way to the great city, beings of all shapes and sizes, from all over the different universes. They began to inhabit the city and call it their home, not only keeping the Eden safe, but keeping her company. Proud of what her "son" had accomplished, Eden let Mythias sleep, let him dream, deep within a tower built at the center of Eden's Crossing. He had given his mother her own eternal kingdom. After a long sleep, Mythias awoke to find that Eden's Crossing had grown.
It's protectors had become strong, and it's inhabitants many. He found his 'mother happy and knew his job was complete. Knowing her 'son's' thoughts, Eden gave Mythias another purpose. To Live. With this new path before him, Mythias set off across the different worlds to find his own will, his own wants, his own needs. The First Seed Of Eden would make his mark and strike his own destiny for sure. Like his mother, Mythias didn't want to be alone and so he began to raise Eden's most powerful seeds as his own children.
One of them was Eden's Beast Of The Earth, Creed.
She was everywhere. The ground that demons walked on in hell, the surface that was radiated by the angel's light in heaven, the surface of the stars and all the planets held in space. They all represented her. And thus Creed's power too, would be drawn from them, as well as the elements of life. Fire was her rage, wind was her breath, and water was her blood. He would feed on the flesh and blood of corrupt man to empower him even further, an Earthen Vampire if you will. He would be able to absorb the blood that stained the earth during battles without even touching, or nearing it. His body would be immune to magic, to the manipulation of time energies. His mind would always be his own. While he couldn't manipulate elemental energies himself, he would feed off of them, use them as sustenance just as he did flesh and blood. His molecular structure would remain untouched unless she willed it otherwise. He would be strong, he would be fast, he would be intelligent, and above all, he would hate mankind. If he was killed in battle, he would return so long as she existed, and she would always exist. He was her testament. He would carry her will throughout the realms, for God's power was so vast, that it could not be held within one reality. She and her brethren existed in many realities. Whether she was called Earth, Terra, Rhydin, or some other name, he would be her Knight. He would be her sword. He would be her vengeance. He was Creed Metatronis Hellgaia. Eden's Beast Of The Earth.
- Who Am I...
The Beast Of Eden
- Romantic Interests
His Abbey
- Relationship Status
- Species


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Comedy, Drama, Judy Greer, Movie, Romance, Visioneers, Zach Galifianakis
Zach Galifianakis, Judy Greer
George: That was Charisma on level 4. Mike won't be joining us today.
Todd: How come?
George: Apparently, according to Charisma on level 4, last night he exploded. He was found in his garage.
Cindy: He didn't seem like the type who would explode.
George (Galifianakis) works at a dull job (think Hudsucker Industries meets…well, the place Tom Hanks works in Joe vs. the Volcano), and he can't seem to work up any enthusiasm for anything in life. Except, that is, for a woman named Charisma who works on the 4th floor. George only knows her voice, but has never seen her. Meanwhile, there's an epidemic across the nation. An epidemic of people literally exploding when their emotional impulses have to fight too hard to get out from behind their dull lives. George starts to think he is experiencing the symptoms of somebody who might soon explode, and he needs to change his life before that happens.
I hope I adequately described the plot because frankly I've already forgotten a lot about this movie. In fact, I've been trying to remember how it ended, and I honestly don't recall what the final scenes in the movie were. I guess that's the sign of a largely forgettable movie.
I enjoyed Zach Galifianakis' understated performance, but the movie as a whole was filled with so many non-events, it all just blends together into a blur of light comedy. The moments I do remember were the more touching ones between George and Charisma who he does finally meet. They're good together, though since George is married to Judy Greer's character, Michelle, it makes the George/Charisma scenes a little less sweet.
It certainly can be a funny movie at times – I especially enjoyed when the company gave all the employees big, stuffed talking bears, hoping it would sooth their nerves and avoid explosions. The problem is, it gets repetitive. There's similar scenes played over and over and a lot of repeated jokes.
All in all, it's a pleasant enough film, I just wish there had been a little more to it. Once I got the point it's making about surpressed feelings and breaking out of the ruts society forces us into, I noticed I was mostly just waiting for it to be over.
A talking, stuffed bear will NOT always keep you from exploding.
10 – 2 for repetitive scenes and jokes – 2 for being so forgettable +.2 for some good performances = 6.2


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In 1922 and 1929, Paraguay was runner up in the South American Tournaments in Rio de Janeiro (Brazil) and Buenos Aires (Argentina). In the next year, by mid-1930, Paraguay was one of 13 nations to make its World Cup debut in Montevideo, Uruguay's funding. In the latter component of the 20th century, the guys's football team contended at the IV World Cup in Brazil.
Throughout that period of time, he had a wonderful job as goalkeeper. He played for Velez Sarfield (Argentina), Zaragoza (Spain) and various other foreign groups. In Spain, Paraguay was one of 2 groups that made its Olympic debut. By the end of the 20th century, the males's football group participated in the worldwide tournament and put 14th.
Paraguay is a Spanish-speaking nation situated in the heart of South America. With more than six million individuals, Paraguay – about the bk8 size of California- is among the most sparsely inhabited nations in the Western Hemisphere. By the very early 1810s, Paraguay ended up being one of the initial independent countries of the world.
Germany/ Portugal
The Germans would surely miss the services of the previous Germany Captain; Ballack, who revealed his retirement after his results with the nationwide group instructor. The kind of efficiency the Germans revealed in the last World Cup was really superior. The Germans has constantly been the side to keep an eye out for and with the likes of Muller and Ozil and bagging a great deal of experience with the present captain, Lahm, the group looks in excellent touch and ought to certainly be one among the leading 4 a minimum of to challenge Spain. Speaking about the Portuguese side, they have actually Ronaldo with them, one of one of the most respected wingers of all time and his speed was just unrivaled. Manchester United winger, Nani too is playing his best football of his career until now. The existing Ronaldo-Nani combination can single handedly do marvels for the Portuguese.


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Current offers
Our top holiday offer for you
Welcome to the Spa Hotel Schwarzbrunn in Tirol!
Spend a brilliant golden spa holiday in the Karwendel Silver Region
Do you enjoy an active vacation? Our innovative outdoor programme is full of surprises! You will see nature in a different light... for example, with picture hiking or a mystic hike through the wild waters of the Wolfsklamm (Wolf's gorge) not far from your Alpine Wellness Hotel and Active Hotel Schwarzbrunn. Are you looking for a Wellness Hotel in Tyrol that is also perfect for families?
Meanwhile, peace seekerswill enjoy the tranquillity of Schwarzbrunn Spa in the saunas, the exclusive wellness and beauty treatments or floating in the indoor "Rock pool" or in the open-air rooftop swimming pool, "Mountain lake"with a view of the Tyrolean Alps.
Book now
Discover how easy it is to get here by car or train!
Experience vacation and enjoy...
...with spa, nature and cuisine all included.
Wellness & Spa
Wellness holiday at the Wellnesshotel Schwarzbrunn in Tyrol
Feel free to relax in our top modern, noble world of relaxation! Experience water, warmth & design on 3,000 m². With open-air roof pool "Mountain Lake", indoor pool "Rock Pool", "Sea of flames", moon relaxation room, sun terrace, winter garden...
To the Schwarzbrunn SPA
Fit, healthy & in a good mood
Naturally on a first-class fitness holiday: In our Fitness & Health Club with 850m² training area you train on the most modern strength and cardio machines. The varied Schwarzbrunn active SPA programme and personal training also feel really good.
To the Fitness & Health Club
Active holidays in the Wellness Hotel Schwarzbrunn in Tyrol
Depending on the season: Hiking to our mountain farm, skiing next to the hotel and in Zillertal, e-bike cycling - you want more? With pleasure! Our outdoor programme includes Smovey walking, Schwarzbrunn Adventure & the active-spa programme!
Nature & active
What kind of vacation would you like?
Vacations in the Hotel Schwarzbrunn:
See the rooms & suites
All the rooms & suites at a glance. Simply choose your room and book.
Last Minute Offers
Book a last minute offer now!
Offers for families
Top spa holiday for families with children in Schwarzbrunn
Spa offers in the Schwarzbrunn
Nothing is more relaxing than a dreamlike spa holiday at Schwarzbrunn. To make your holiday here in Tyrol a relaxing experience, we provide you with our spacious wellness area and our excellent expertise with our soothing treatments and massages. Because you earned it! Highlights at the Schwarzbrunn SPA:
- 3,000 m² ultra-modern spa area
- Relaxing spa and wellness treatments
- Rock pool, roof pool, whirlpool, glacier water, ...
- Extensive all-inclusive-superior services
- Enjoy the sensual natural landscape of the Tyrolean Alps
Offers for active holiday makers
Hiking, biking, skiing ... and enjoying nature.
Offers for skiiers
Enjoy the winter right at our doorstep.
Offers for connoisseurs
A holiday full of relaxation and culinary highlights.
The Hotel Schwarzbrunn on the sunny side of the Tyrolean Inn Valley in the Karwendel Nature Park.
Thanks to the ideal transportation connections to the Inntal motorway and trains (Jenbach, Stans and Schwaz railway stations), hotspots in Tyrol, such as the state capital Innsbruck with its sights, the Zillertal, the Achensee and many other excursion destinations can be reached in a very short time.
Excursion destinations in Karwendel and the vicinity
The Wolfsklamm Gorge
Steps and climbs lead through the Stanser Wolfsklamm between rock giants and thunderous waterfalls. The unique natural spectacle can be reached directly behind our hotel in approx. 10 minutes. Admission is free for guests of our Hotel Schwarzbrunn!
More about the Wolfsklamm in Stans
Free admissions in Tyrol
- for direct bookers -
Depending on opening hours and season, direct bookers enjoy the advantage of free admission. For eexample, to the Swarovski Crystal Worlds in Wattens, the Tratzberg Castle in Stans, Bergisel Ski Jump in Innsbruck....
Free admission
Discover the cities
The silver town of Schwaz in Tyrol (5 minutes by car from the Hotel Schwarzbrunn) invites you to discover numerous sights that date back to the heyday of silver mining.
The Tyrolean capital Innsbruck (25 minutes by car from the Hotel Schwarzbrunn) attracts with the Golden Roof, the old town, the impressive mountain scenery and much more.
Discover cities in the region


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PITTSBURGH (AP) — The Pittsburgh Steelers will be on the field during the national anthem in next weekend's game against the Baltimore Ravens.
Every Steeler but left tackle Alejandro Villanueva remained in a tunnel while the anthem played before a loss in Chicago on Sunday. Ben Roethlisberger says the team asked Villanueva to join the other captains at the front of the line before kickoff and a miscommunication led to Villanueva, a West Point graduate and Army veteran, being left alone by the field.
Defensive end Cam Heyward says the Steelers never wanted Villanueva to feel like his teammates don't have his back. Heyward says Villanueva was shocked by the picture of him standing alone.
Roethlisberger says the team hasn't decided yet whether players will stand or kneel during the anthem in Baltimore but that he wished his team had approached the situation differently.
He released this statement today about Sunday's pre-game decision:
I was unable to sleep last night and want to share my thoughts and feelings on our team's decision to remain in the tunnel for the National Anthem yesterday. The idea was to be unified as a team when so much attention is paid to things dividing our country, but I wish we approached it differently. We did not want to appear divided on the sideline with some standing and some kneeling or sitting.
As a team, it was not a protest of the flag or the Anthem. I personally don't believe the Anthem is ever the time to make any type of protest. For me, and many others on my team and around the league, it is a tribute to those who commit to serve and protect our country, current and past, especially the ones that made the ultimate sacrifice.
I appreciate the unique diversity in my team and throughout the league and completely support the call for social change and the pursuit of true equality. Moving forward, I hope standing for the Anthem shows solidarity as a nation, that we stand united in respect for the people on the front lines protecting our freedom and keeping us safe. God bless those men and women.