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Stanford women's rowing alums Grace Luczak and Elle Logan each medaled at the World Rowing Championships this past weekend in Aiguebelette, France.
Luczak, a 2011 Stanford graduate, captured the gold medal in the two-seat of the United States Women's Four. The U.S. finished the A Final with a time of 6:25.220 to defeat second-place Great Britain by more than six seconds (6:31.520).
Logan, who also graduated Stanford in 2011, stroked the United States Women's Pair to the bronze to give the U.S. a qualifying spot in the 2016 Olympics in Rio de Janeiro, Brazil. The U.S. finished the A Final with a time of 7:00.550, behind gold medalist Great Britain (6:52.990) and silver medalist New Zealand (6:56.750).
"You have to work so hard every day when you can't see the competition, and even at home when we're competing with some of the best in the world on our team," Logan told Row2k. "That's why it's been so exciting (to row the pair). We both love it so much, and we're so happy that we have the opportunity to race in it."
Logan is a two-time Olympic Gold medalist, capturing her first gold medal in the United States Women's Eight during the 2008 Olympics in Beijing while an undergraduate at Stanford. She won her second gold in the U.S. Women's Eight in the 2012 Olympics in London.


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Last Update
May 23, 2018
The P2PS Foundation is an independent body governed by the Foundation Council. The Foundation has been authorized to create a worldwide network of digital services that encompasses an alternative working model to the traditional models of peer-to-peer networks. The alternative working models of peer-to-peer networks must be on Blockchain and compliant with Crypto technologies that are conclusively acknowledged as technologies of the future.
Currently and in the immediate term, the usage for P2PS tokens would extend beyond the North American continent to the Middle East, providing a Serviceable Obtainable Market (SOM) of about 110 million users from the 220 million potential users which constitute the Total Available Market (TAM) size (The World Factbook). The current clients of P2P Solutions Foundation, among others, are Electronic Leaning Inc. (ELI), (Electronic Learning Inc.), a pioneer in eLearning solutions and the ISI group consortium. Since both ELI and ISI Group caters to education, the Government & Defense, Banking & Finance market segments, the P2PS token has immediate acceptability with a ready client base in North America, Europe and Australia as well as the Middle Eastern countries. Moreover, both ELI and ISI group are headed for diversification into other global markets such as Europe, South America, China, etc., providing P2PS tokens a wider market penetration.
Therefore, it is anticipated that the P2PS token would proliferate and quickly command a predominantly large market share in the years to come. Through ELI and ISI group clients alone, P2PS tokens have a high potential growth trajectory. Moreover, P2P Solutions Foundation anticipates that over the next 5 years, the SOM for users in the top 49 high potential countries globally that are known to quickly adapt and embrace secure, digital transaction systems, is about 772 million users off the Serviceable Available Market (SAM) of 1.1 Billion and TAM of 1.5 Billion users.
P2PS token will be used on secure platforms. One such platform that has committed to embrace the P2PS token is the secure, interference free, peer to peer, digital delivery system (Push System protocol), promoted by Innovative Solutions International Inc. (ISI). The P2PS crypto-token is needed by anyone desiring to use the Push System protocol.
The Push System protocol was developed in 2010 by ISI, a research and development corporation incorporated in USA, in response to the huge gap in the closed or locked down computer systems market segment. The Push System protocol, in short, is a High Speed Large Digital Data Package Transfer System on the secure peer-to-peer proprietary networks. The P2PS token will assist you in all your transactions on the decentralized, secure and interference free Peer-to-Peer Digital Delivery System that is used in Government & Defense, Digital Education & Delivery, Medical & Pharma, Banking & Finance, and other corporate sectors.
2014 - 2017
November 2017
15 December 2017
28 February 2017
Apr 02, 2018
Aug 31, 2018
December 2018
March 2019
Verified 70%
Attention. There is a risk that unverified members are not actually members of the team
77 ICOs
$515 500 429
$4 075 000
11 ICOs
$2 759 175
Verified 0%
54 ICOs
$341 970 441
$72 681 930
44 ICOs
$216 326 667
Positives Information Storage: P2PS has a great way of keeping your information secure. For example, once a user uploads their data onto their platform, that information is stored, divided and scattered. Decentralized Storage: There is no limit as to how much data you plan to upload as P2PS has no limitations in that regard. For example, you'll be able to save up 2TB worth of data without having to way about paying extra for the extended service. Promising Roadmap: All of the information about this ICO's roadmap is clear, concise and is realistic. If they follow all of their goals presented on their roadmap, then their project will reach its success and potentially surpass their competition. Negatives No MVP: While this is a great project, P2PS needs to have an MVP so that users can actually use their service. This might turn some investors away until a fully developed app is completed. Token Pricing: For some, paying 0.06 BTC for 300 P2PS coins can be expensive for some users. If the project lowers some of their token prices, they might increase the chance of obtaining their soft cap and hard cap goals.
This offer is based on information provided solely by the offeror and other publicly available information. The token sale or exchange event is entirely unrelated to ICOholder and ICOholder has no involvement in it (including any technical support or promotion). Token sales listed from persons that ICOholder has no relationship with are shown only to help customers keep track of the activity taking place within the overall token sector. This information is not intended to amount to advice on which you should rely. You must obtain professional or specialist advice or carry out your own due diligence before taking, or refraining from, any action on the basis of the content on our site. Any terms and conditions entered into by contributors in respect of the acquisition of Tokens are between them and the issuer of the Token and ICOholder is not the seller of such Tokens. ICOholder has no legal responsibility for any representations made by third parties in respect of any Token sale and any claim for breach of contract must also be made directly against the Token issuing entity listed herein.
If you have any concerns about the nature, propriety or legality of this token sale or the persons involved in it please contact [email protected] with detailed information about your concerns.

subset: commoncrawl


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This top is made from interlock viscose jersey. It's designed with a cut-out front and flexible mesh yokes for a semi-sheer finish.
93%Viscose-Rayon 7%Elastane-Spandex, Contrast 92%Polyamide-Nylon 8%Elastane-Spandex
Size & Fit
- Model is wearing a size XS and is 177 cm / 5'9"
- Size Info


text: My name is Joshua Mapley and I'm a fresh new voice on the scene, I can do voices In many accents such as australian, american, english, irish and more. Not only can I do realistic voices but I can also distort my voice to do creature noises, and voices that would be more tailored to suit a cartoon or video game character. Feel free to contact me with any work you may need done, even if it may seem outside what I can do as i have a rather flexible range.


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Digital Marketing strategy for a social customer experience company
Company Background
LiveWorld is a Social Customer Experience company helping companies improve their customer experience by managing conversations in messaging apps and social media to develop deeper relationships with customers
Problem Statement
LiveWorld was seeking a digital marketing partner to take over their PPC and SEO operations, optimize the overall health of the account and bring in measurable results.
The first step was to conduct a comprehensive audit to identify opportunities and problem areas from both an SEO and a PPC point of view. Once that was done we formulated an overall strategy to optimize the website and also improve paid marketing results. The SEO strategy included migrating to a secure HTTPS protocol and also optimizing key SEO elements on the website. When it came to PPC, we devised a 3 phase AdWords strategy to enhance account health & performance. We also devised a KPI framework, measurement framework and conducted attribution analysis to understand channel level metrics. This helped attribute conversions to specific channels and report the number of conversions each channel assisted and completed and provided a better marketing view to LiveWorld
- Built User persona level marketing dashboards for the marketing team
- Fixed conversion and lead attribution inconsistencies
- Helped Liveworld Team successfully reposition their product and service lines and build channel level strategies
- Improved user segmentation using website analytics


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This EVOC Bike Travel Bag Assessment is more thorough than most. I've utilized a lot of distinct bike bags and travelled a lot, so wanted to give you my take on this bag.
So it has been awhile considering that I have been updating my Weblog. With Facebook, Google+ and what ever else there is out there I attempt and maintain for my enterprise Discovery Sea Kayaks , it is tough to do considerably more. But I decided I wanted to reopen the use of my Blog to inform readers on all kinds of news, events and even some of my enterprise going's on.
Even though the route uses parts of Higher Street and Court Street, rather of these the existing bike map and recommendations are to use Church Street (or Winter Street) and Chemeketa Street. Church street is flat in this segment, and Chemeketa Street is two-way. This mismatch in street choice is significantly less important than the others, but we should leverage our current network suggestions rather than producing various ones to overlay in parallel.
Sir. I bought bajaj pulsar 150 dtsi on December 2015. Salesman told me prior to service it will give about 30 kmpl mileage. And I was getting around 34Kmpl. So my query is my bike mileage will improve?. Will it enhance afrer service… or service doesn't matter. What is the top mileages of my bike im each way cities and in highway. And how to increase mileages. Iam riding bike at 50-60kmph on 4th gear. What speed i have to stick to to shift each and every gear. Please assist me.
The bicycle was designed as the 1st personal kind of transport. When compared to vehicle, it requires far less power to produce and use in the extended run. Till the day the energy required to run the vehicle becomes as well costly for individuals to afford, the bike is going to be a secondary kind of transport for the major counrties like western Europe and North America. The transportation systems in Europe are created to deal with the use of bike use. North American's are far behind in this location. The micro bike style makes sense in a location exactly where you have a very good mix of very good public transport and bike friendly road methods.


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[Source: US Centers for Disease Control and Prevention (CDC), Emerging Infectious Diseases Journal, full page: (LINK). Abstract, edited.]
Volume 26, Number 2—February 2020 / Research Letter
New Delhi Metallo-β-Lactamase-5–Producing Escherichia coli in Companion Animals, United States
Stephen D. Cole, Laura Peak, Gregory H. Tyson, Renate Reimschuessel, Olgica Ceric, and Shelley C. Rankin
Author affiliations: University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, USA (S.D. Cole, S.C. Rankin); Louisiana State University, Baton Rouge, Louisiana USA (L. Peak); US Food and Drug Administration, Silver Spring, Maryland, USA (G.H. Tyson, R. Reimscheussel, O. Ceric)
We report isolation of a New Delhi metallo-β-lactamase-5–producing carbapenem-resistant Escherichia coli sequence type 167 from companion animals in the United States. Reports of carbapenem-resistant Enterobacteriaceae in companion animals are rare. We describe a unique cluster of blaNDM-5–producing E. coli in a veterinary hospital.
Keywords: Antibiotics; Drugs Resistance; Carbapenem; Beta-lactams; NDM1; USA.


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If only I could clink my wine glass with yours through the screen because Decadence Fashion is officially two years old! I want to start off by expressing how thankful I am for the endless amount of love and support you've all shown me throughout these past two years. Obviously when I first started my blog, I had no idea what would foster from it nor did I even expect others to pay attention to it – I just did it for myself. Your support is a huge bonus and it means the world.
A couple months ago I shared with you why I started blogging in the first place. Now that it's been two years, I've recognized a lot of valuable things about myself and what I want for my future. The reason why I'm telling you this is because I believe these lessons can be helpful, and hopefully worthwhile, to incorporate into your own life.
Self-reflection is a huge part of continuing to be the best version of yourself. There's always room for improvement and always opportunities to strive to be better; and this starts with reflecting on where you've been to know where you're going:
1. Put yourself first. No matter what point you are at in your life, it's absolutely necessary to put yourself first. That's right, you heard me. Even in your dearest friendships and relationships, put yourself first. That doesn't mean to sound selfish because it's what will ultimately set yourself up for success. Practicing mental and physical self-care is the root to thriving in all other aspects of your life – including your relationships and career.
2. Do what you love and a lot of it. Focusing your energy on your passions and what truly brings you joy will help you better understand yourself and understand what you want. Self-discovery and self-realization are products of experiencing the world around you and doing what you love. You need to live your own life and be happy for you (and you alone). From there, everything else will fall into place.
3. The only opinion that matters is your own. Coming from someone who used to solely live their life caring about other's perceptions, this was a huge hurdle for me. It wasn't until I reached my breaking point and gained clarity to the idea that I actually shouldn't give two f**ks (excusez-moi my language) about what anyone else thinks. In reality, the people that judge you or mistreat you are purely doing so in reflection of their own insecurities. Keep doing you and stand up for yourself – these people aren't worth your effort to convince them otherwise.
4. If your dreams don't scare you, you're not reaching high enough. If you have dreams and goals, realize that it can actually happen – you just need to put in the effort to make it happen. Dreams can be reality if you work hard enough for them. It can be intimidating and it will be a challenge, but it will be completely worth it. Those who you see living out their dream once started at the bottom too.
Life somehow has a perfect way of working out and teaching you a thing or two along the way. Be thankful for where you've been and continue to work hard for where you want to be. The grass is always greener. Here's to another 2+ years of content and exciting things for Decadence Fashion. Thank you all for being on this ride with me so far!


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Learn how language affects Scripture with Dr. Runge
Our understanding of the Greek New Testament is based almost entirely on English translations, but how would our understanding of the Greek text change if we read it for what it is—as Greek? With the Lexham Discourse Greek New Testament Datasets, we can now get behind the words of the New Testament writers and discover the particular linguistic tasks that inform translation and interpretation. The Lexham Discourse Greek New Testament Datasets identifies discourse markers and performs complex discourse analysis of the entire New Testament quickly, easily, and accurately, which makes it one of the most advanced tools for studying the Greek text of the New Testament.
Get Lexham Discourse Greek New Testament Bundle today!
Choose Joy with Kay Warren
Ever wonder why some people seem to experience joy in their daily lives–even in the tough times—and others can't seem to find it no matter how hard they search? Is a joy-filled life really possible? The answer is yes! And it's possible for every woman, no matter what her circumstances may be. In Choose Joy: Because Happiness Isn't Enough, Kay Warren teaches women what joy really is, where to find it, and how to choose it in the good times and the bad. With compassion and wisdom, she shows readers—even those who live with the constant companions of discouragement and depression—that true joy is deeper, richer, and more accessible than they might think. Perfect for small groups or individual reading, Choose Joy will empower women who feel like their emotions and well-being are at the mercy of others by helping them understand the life-giving truth that joy is within their grasp—every day.
Get Choose Joy today! Or check out the Hope for Mental Health Starter Kit.
Get training in biblical counseling from Tim Clinton, Gary Thomas, Eric Johnson, and more
Mobile Ed lets you learn from some of the top biblical scholars in the world, right from home. And with these courses from Clinton, Thomas, and Johnson, you'll gain knowledge and skills to offer biblically-sound counsel, whether you're a pastor, therapist, or small group leader.
Check out all our biblical counseling courses here.
Save on Logos products all November long
Save up to 40% off select resources during the November monthly sale.


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News Release
Inexperience and Inattention Cause of Youth's Injury Following Collision with SUV
Case Number: 16-OVI-178
The Director of the Special Investigations Unit, Tony Loparco, has found a Halton Regional Police Service officer's actions did not contribute to a collision between a dirt bike and an SUV that resulted in a fractured toe for the 17-year-old dirt bike rider. The Director determined the injury was caused by inexperience and inattention.
The Director's Report was delivered to the Attorney General, as is required by law under the Police Services Act. The Attorney General has directed that the document be posted online. It can be found at https://www.ontario.ca/page/special-investigations-unit-siu-directors-reports.
The SIU is an arm's length agency that investigates reports involving police where there has been death, serious injury or allegations of sexual assault. Under the Police Services Act, the Director of the SIU must
- consider whether an officer has committed a criminal offence in connection with the incident under investigation
- depending on the evidence, lay a criminal charge against the officer if appropriate or close the file without any charges being laid
- report the results of any investigations to the Attorney General.
Lisez ce communiqué en français.SIU Communications/Service des communications, UES
Telephone/No de téléphone: 416-622-2342 or/ou 1-800-787-8529 extension 2342


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Kia Dealer Serving Hobbs, NM
If you are comparing Kia dealers in Hobbs, New Mexico consider our Kia dealership offering the full lineup of Kia Cars and SUVs including new Kia Stinger, Niro, Cadenza, Forte, Optima, Optima Hybrid, Rio, Rio 5-Door, Soul, Sorento, Sportage and the all-new Kia Telluride. We also offer an extensive selection of used cars, including many used Kia Cars and SUVs. Browse our new and used inventory online, compare prices, see color options and trim levels then come by for a test drive.
Our auto financing experts will explain finance and leasing options for a new Kia or affordable used car. Kia dealer special offers and factory incentives are frequently available to help you get the very best price. Just ask us about our new Kia specials and discounts on Used Cars, trucks and SUVs.
If you are looking for reliable Kia service and repair we also have a complete auto service and collision repair center and a fully stocked Kia parts department. Take advantage of our service coupons and Kia service specials for oil changes, tune ups, brake service, and much more.
Our Kia dealership near Hobbs, NM, has a great selection of vehicles for sale, excellent prices, special offers, expert auto service, repair and parts. Why go anywhere else?


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About This Center
Shambhala is a global community. There are more than 170 centers and groups around the world, as well as thousands of individual members. Shambhala Meditation Centers offer courses in meditation and other contemplative arts and disciplines, and also host community gatherings, celebrations, and family events. In community life, we endeavor to put into practice the principles of courage and compassion. This helps us to experience daily life as a constant opportunity for spiritual practice and social service.What we Offer
Meditation is a natural state of the human mind—at rest, open, alert. The practice of meditation has been taught for over 2,500 years as a vehicle for realizing the beauty and magic of the ordinary world without aggression or manipulation.
The teachings of Shambhala Buddhism emphasize the potential for enlightenment inherent in every situation or state of mind. Through discipline, gentleness and a sense of humor, the practitioner is invited to let go of conflicting emotions and wake up on the spot.
Mindfulness/awareness meditation is the foundation of all that we do at the Shambhala Meditation Center.This ancient practice of self-discovery is rooted in the simple but revolutionary premise that every human being has the ability to cultivate the mind's inherent stability, clarity and strength in order to be more awake and to develop the compassion and insight necessary to care for oneself and the world genuinely.


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The second annual Penetration Risk Report from cybersecurity consultancy Coalfire tested 525 businesses for their susceptibility to a range of different hacking techniques and security vulnerabilities.
Employees at 71 percent of these businesses willingly offered up access credentials when targeted with phishing attacks by Coalfire's penetration testers. In 20% of cases, credentials were shared by more than half of employees.
Human error was a persistent theme across throughout the research with weak passwords and insecure internal procedures both in the top three most common vulnerabilities discovered by the research, alongside out-of-date software.
Andrew Barratt, UK managing director at Coalfire, said: "Our research proves that you're only as strong as your weakest link when it comes to cybersecurity. A lot of businesses are taking steps to upgrade their security infrastructure, particularly as they migrate more systems into the cloud, but still aren't addressing some of the fundamentals.
"The continued vulnerability to basic hacking techniques like phishing is a disaster waiting to happen for a lot of businesses. Coupled with the increased risk caused by out-of-date software and security misconfiguration our research uncovered, it's clear that some routine security tasks are clearly still being neglected.
"It only takes one employee to click on the wrong link or unwittingly share sensitive information to a fraudulent email and a hacker is in. This makes security basics like limiting employee access based on their role as well as educating staff on how to use IT safely and how to spot suspicious activity vitally important."
Organisations struggle to get cloud configurations right
Overall, businesses exhibited fewer high-risk vulnerabilities than they did in Coalfire's 2018 report. But as firms move more systems into the cloud, coordinating and configuring multiple infrastructure providers and hybrid environments has become a major challenge.
Mike Weber, vice president Coalfire Labs – the security firm's technical testing division – said: "We believe that the improved security postures we're seeing are due to the shift toward cloud solutions. This reduces the need to secure and maintain on-premise IT assets and enables businesses to benefit from their service providers security infrastructure.
"There is a misconception from many that cloud adoption automatically means accepting more risk but this is only true if it's done poorly. Program managers should evaluate all components and leverage cloud services into their threat models to create effective, layered security solutions when building applications in the cloud."
The threat landscape changes in the cloud
Coalfire Labs tested cloud service providers and general businesses separately to pinpoint the risks specific to each environment. For non-cloud enterprises the top three vulnerabilities were out-of-date software, insecure protocols and password flaws.
The top three cloud application vulnerabilities were cross-site scripting, injection and security misconfiguration.
Retailers are streaking ahead when it comes to reducing risk
Coalfire's research looked at five key sectors – tech, retail, healthcare, education and financial services. It found that retail businesses had made the most progress in reducing vulnerability in their IT environments.
Financial services saw the biggest increase in risk from external attacks, compared to 2018. Compliance struggles, privacy management, increasing third-party vendor assessments and ongoing payment card industry challenges combined to produce a 17% external risk increase over the last year.
Big businesses close the gap
Coalfire's 2018 report found that medium-sized businesses were generally better at protecting themselves against cybersecurity threats than their larger peers. But this has been flipped on its head this year with large enterprises, across all sectors, exhibiting less vulnerability.
The testing found that big businesses were more likely to have taken the time to proactively test solutions before going to market.


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"Awana helps churches and parents work together to develop spiritually strong children and youth who faithfully follow Jesus Christ. Our programs offer a proven approach for evangelizing and discipling kids in the church and community."
One of the programs that Awana offers is the Sparks program. The Sparks program is divided into three years. "In three years, Sparkies will survey the main people and events of the Bible. Not only will they learn specifics, but they will also see how the whole Bible fits together as God's plan to save the world through Christ."
Price subject to change without notice.
The program I received to review was Wing Runner. The Wing Runner program is for children in the 2nd year of the Sparks series. The kit includes tools for discipleship at home: entrance booklet, student handbook, verse music CD, and a parent handbook so the adult can learn alongside her child.
The entrance booklet featured the characters Sparky the Firefly and his friends Chloe, Jacob, and Joel. My daughter loved reading the booklet to me and I loved that it helped her to remember John 3:16. We also enjoyed listening to the music, sound effects, and the dramatic readings in the review CD. When we were completing the activities in the Sparky book, I would have her read the stories but sometimes she only wanted to listen to the CD. I loved that the CD provided a song to help my daughter remember all 27 books of the New Testament. She also loved the word search that incorporated the name of some of the books found in the New Testament. I loved being able to discuss the Bible and sections found in the book with my daughter.We loved this program so much that she is looking forward to participating in an Awana program.
I have been given this product free of charge for review purposes


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Sweet Sunflower yellow and gray boutique swing top with ruffled bloomers, baby, toddler, summer,
$16.99Pin It Tweet
This gorgeous sweet sunflower yellow and gray swing top and ruffled bloomer set is perfect for a hot summer day, a trip to the beach, or a pool party! The bloomers include layers of ruffles. The outfit is made of a cotton/spandex blend and is elasticized for a flexible fit. This is a breathable, cool outfit. Add the Yellow Bow for extra cuteness!
Small 0-6 months
Medium 6-12 months
Large 12-18 months
XLarge 18-24 months


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Brazos River
Regional Day School Program for the Deaf
Brazos River RDSPD Family Night
Thursday, Jan. 26th, 6-7pm
Parker County Co-op Special Services, 612 N. Rusk St. Weatherford, TX 76086
FREE Ipad or other equipment!!!! Come learn how to sign your DHH student up for free equipment to help with equal access for telecommunication. Gema DeLaO and Leslie Seggalink will present about the STAP Program. This is the Specialized Telecommunication Assistance Program. Please bring your driver's license or other proof of address.
Olivia Brooks,2016 WHS graduate, shares about her freshman experience at SWCID
South West Collegiate Institute for the Deaf from Big Spring,TX visited WHS on January 4th.
John Green from SWCID presents to students of the RDSPD
Brazos River Regional Day School Program for the Deaf
Serving Deaf/Hard of Hearing students from birth through age 21 years in North Texas School Districts including those associated with the following Special Education Programs: Central Texas Shared Services, Erath County Special Services, Granbury ISD, Hood Somervell Special Ed Co-op, Palo Pinto Special Services, Parker County Co-op, Springtown ISD, Stephenville ISD, Weatherford ISD.


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The biggest fight in the history of Mixed Martial Arts is upon us. Two dominant champions collide in what will be a swashbuckling display of hard work and skill in UFC 229 at Las Vegas on October 6th.
Khabib Nurmagomedov is arguably the most dominant fighter who has set foot in UFC's Octagon. His professional fighting career record of 26 wins and 0 losses in unparalleled. It is also widely accepted that Khabib is yet to lose even a single round in his MMA career! As a kid, there are videos of him wrestling bears as well.
On the other hand, we have the biggest combat sports star in Conor McGregor. The Irishman has always backed up his flamboyance and shenanigans outside the fighting career. McGregor possesses an unbelievable understanding of timing and distance when it comes to striking. One punch knockout power has helped McGregor not only capture the UFC Featherweight Title (145lbs) but also the UFC Lightweight Title (155lb).
This going to be a war between two of the best fighters in the world, and so here we provide you with the betting odds for the mammoth fight.
But first, let's focus on the strengths and weaknesses of the two guys fighting in the main event on Saturday.
The Dagestani fighter has mauled every single fighter he has faced till now. His pressure and wrestling game has broken every one. He has an endless gas tank and isn't afraid of taking some shots to close the distance to get the hold of someone. When he is on top of you, it is almost impossible to get up, as he uses supreme technique coupled with constant transitions, while punching your face into a pulp to deflate your ego. In his own words, "Smash" is what he does to his opponents, and all 10 fighters in the UFC he competed with have received the same treatment.
But, his striking has always been questioned. In his last fight at UFC 223 against Al Iaquinta, he looked a bit sloppy. He keeps his chin up and doesn't like getting hit that often. In fact, in a fight against an elite striker in Edson Barboza he ate all the shots and leg kicks to close in the distance. This might be a mistake against someone as elusive as Conor, who is known to throw that kill shot and shut out the lights.
The Notorious one has been known as one of the lethal strikers in the game. He stands in the southpaw stance and uses every limb to make use of his long reach. Even though he isn't that tall, he can hit from different angles, confusing his opponents. He also possesses one hitter quitter, which has won him two titles. Against Jose Aldo in UFC 194, he slept the then Champion of 10 years in 13 seconds. He did the same to UFC Lightweight Champion Eddie Alvarez at UFC 205. Few people have been able to stand with him past two rounds, and one of them was Nate Diaz.
However, he has limited gas tank. Because he is so explosive, he also gets tired easily. In the last two fights he lost, fatigue played a major role. Also, his ground game has been questioned, but we don't see it as being that big of a problem. With Khabib it's not a matter if he can take you down, it's when. If Conor exerts a lot of energy getting up back on his feet, and is pounded out all the time, his cardio will take a massive hit. He needs to keep this fight standing as long as he can, and wait for the shot on the Khabib's chin.
Khabib is the favourite to win this fight. He is a -180 favourite. We believe this is the right call as he has a more formidable record, and the style of fighting he employs is an antidote to Conor's. McGregor is a +155 underdog, and a lot more money will come in on him before the fight. We expect these odds changing come Saturday night in the USA.
The odds for Khabib finishing Conor by either KO or submitting are here. William Hill and Betfair are giving a 7/2 chance of Khabib knocking out Conor. While for submission the odds are 13/5.
If this fight goes all five-rounds and Khabib is victorious then William Hill are giving 7/2. It is quite possible he can drag out this fight for five rounds as Khabib wants to humiliate McGregor.
Conor McGregor winning this fight by knockout has high odds. William Hill gives a 13/8 chance if McGregor knockout Khabib and 20/1 odds if he submits Nurmagomedov.
Even though it is extremely unlikely that Conor will win this fight after five rounds, the odds of him pulling this feat off are 10/1.
Both fighters are of exceptional talent. The style matchup is perfect when it comes to MMA. An elite striker against a wrestler who mauls people. If this fight goes to the ground, it will be discouraging for Conor as Khabib will dominate him easily. It is not about his strength, it's the technique and unrelenting pressure. He overwhelms you. But, Conor can also catch Khabib coming with a left on the nose, dropping the Russian and finishing him off. A tough call, but we believe Khabib Nurmagomedov will be retaining his UFC Lightweight Championship title and become 27-0 in his professional career.


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It's 1942 England and we're in an underground bunker with servicemen and woman who are - of all things — putting on a radio show of Shakespeare's Much Ado About Nothing.
Prague Shakespeare Company is back in Houston at Main Street Theater, this time bringing with it an early comedy by Shakespeare. Guy Roberts, CEO and artistic director of the company acknowledges that Houston audiences have had plenty of opportunity to see fine productions of Much Ado lately (the Houston Shakespeare Festival this summer and 4thWall Theatre Company's just concluded run) but he says there is still room for more.
"What makes our production unique is that each performance is audio-streamed live over the Internet ala an old fashioned radio play," Roberts says. Audiences will be able to watch actors not only act out the play but will have a behind-the-scenes opportunity to watch actors create the needed sound effects for a radio broadcast.
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All the costumes and most of the props from Prague, says Roberts of the show that opens on New Year's Eve. Prague Shakespeare Company just became the first theater company in the world "to share the newly accepted Shakespeare canon in one year." That's 41 plays, and 154 sonnets and poems.
Thirteen actors, some local and some from five other countries make up the cast. As Beatrice and Benedick battle their way to love, watch for the "extreme German accents" of some of the characters.
Performances are scheduled for December 31 through January 15 at 7:30 p.m. Wednesdays through Saturdays and 3 p.m. Sundays at Main Street Theater – Rice Village, 2540 Times. For information call 713-524-6706 or visit mainstreettheater.com. $36-$45.


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Nicola discovered Pilates in 2001 and was amazed at how quickly her balance, flexibility, strength, and coordination improved. Inspired by the changes in her body, Nicola pursued Mat and Equipment Teaching Certifications through The Kane School of Core Integration (now called Kinected) in NYC, one of the most distinguished training institutes in the US. She taught at Erika Bloom Pilates before moving to North Carolina 2009. In NC, Nicola taught at the award-winning studio InsideOut Body Therapies. She also co-created the Pilates program at Duke University and taught there for six years. Through her tenure as a Pilates teacher in NC Nicola cultivated long-term relationships with many clients, including several in-home clients. Since moving to Berlin in 2016 Nicola has continued teaching Pilates and enjoys occasionally practicing her German in classes! Nicola has worked with the young, aged, healthy, recovering, active, idle, prenatal, postnatal, experienced, and inexperienced. Throughout, Nicola has maintained her own Pilates practice and continues to find inspiration in all that it offers!
I teach because I love sharing the joy of movement. I believe passionately that the best way to feel better and improve our lives is through empowered and supported movement. My teaching style combines classical Pilates repertory with a contemporary understanding of anatomy, biomechanics, and an individual's needs. I strive to meet my students wherever they are, without judgement or expectation. That being said, I do like to push my students to find new and deeper sensations and movements! As a dancer, I have experienced many different techniques and approaches to movement. I often incorporate these styles, including contemporary dance, yoga, Gyrokinesis, Feldenkrais, and Klein Technique, into my teaching.


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Josie Whitney
Star Rating: 4 Scent: 3
Petal Count: 35 Flower Size: 10 cm
Flowers per Cluster: 3-7
90 cm tall x 60 cm wide
A riotous feast for the eyes. Ablaze with colours resembling the flames of a roaring fire, the flowers go through intense red, burnt orange and glowing golden yellow. The cool, gleaming foliage provides the perfect accompaniment. Plants are sturdy, upright and nicely proportioned. Josie Whitney makes a bold impact in any garden. Suitable for sun or part shade. Water regularly, but avoid veering from flood to drought. Use in beds, borders and groups.
Registered Name: Harfacey
Also available as a Bare Root Rose


text: Post by Daniel Kim Law (@danielkimlaw) on Mon, 15 May 17 08:27:45 +0000 View Full Post Motorcycle Accident Attorney Near Me Statistics show that most motorcycle catastrophes end up with injuries and serious damages and losses. These are often very expensive and for that you will need to get the services of an experienced and skilled lawyer. Such an attorney can help guide you through the various complex procedures involved in a motorcycle accident. Motorcycle Accidents are often very dangerous and can be fatal because of the lack of protection that motorcycles have. Sneak a peek at this web-site http://www.thecaraccidentlawyer.org/motorcycle-ac... for more information on Motorcycle Accidents. Follow us : https://goo.gl/mevW94 https://goo.gl/6nxexl https://goo.gl/ClrQcn https://goo.gl/6nxexl https://goo.gl/wuVtXy


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Thank you for contacting the European Environment Agency (EEA).
The EEA has a dataviewer that shows the number of plants per country reported under the Urban Waste Water Treatment Directive (UWWTD). Countries are obliged to report plants serving over 2000 population equivalent (p.e.), but the EEA doesn't have details for smaller treatment plants. Please see
https://tableau.discomap.ee[…]unt=no&:showVizHome=no. (Tab: "plants in numbers" and then select the desired Member State)
You might also be interested in the details provided in the Commission's compliance report for the UWWTD: http://ec.europa.eu/[…]/implementationreports_en.htm.
We hope that this information will be useful for you.
With kind regards,
EEA Enquiry Service
Best regards,
Rodrigo Arandi-Klee


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8 commercial property sales signed by Bayleys agents include Alpha Hopetoun at the top of the central city, one leasehold site and the lessor's interest in another.Read more →
Le Parc
Update: Kiwi on Queen units sell at $7000/m²
2 identical one-bedroom units in the Kiwi on Queen apartment block at the top of Queen St (pictured) sold under the hammer for $239,000 each at Ray White City Apartments' auction yesterday, at $7024/m². They were among 7 sales out of 11 apartments on offer at the auction. Update: One of the properties passed in, […]Read more →
Dilworth & Farmers units sell, leaseholds passed in
A Dilworth unit and one in Heritage Farmers were sold under the hammer at Ray White City Apartments' auction today.Read more →


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MORE than 100 Blackley villagers came out in force, last Saturday, to reinforce their right to walk local footpaths and rights of way.
Led by Dr Edgar Ernstbrunner, chairman of the local branch of the Pedestrians' Association, villagers enjoyed a full day's "yomping", before stopping for a well - earned drink at Hartley Downs' pub,The Old House At Home, on Bottomley Side.
Most of the walkers were members of the recently-formed Blackley Village Community Association.
Chairman, Sarah O'Neill, reported that while many of the footpaths they walked on Saturday have not been claimed, in Dr Ernstbrunner's opinion, villagers have the right to register them because they are extensions of long-established paths, some of which continue from one side of the village to the other, even if they are bisected by roads.
She added: "In a climate where it is easy to get swallowed up in a corporate frenzy of building and redevelopment, we in the village are determined to try to redress the balance.
"Blackley Village has been in existence since Tudor times and after decades of neglect, we are determined to turn the tide. Part of this philosophy includes doing all we can to keep the village's ancient pathways and identity."
Members of the association are now busily collating the necessary documentation required to state their claim on the walk ways.


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2016 Camp Officers
Commander- Hawk Bennett
1st Lt. Commander- Charles Thacker
2nd Lt. Commander- Tommy Joyner
Adjutant- David Bohmfalk
Chaplain- Johnny Davis
2014-2015 Founding Camp Officers
Commander – Peter Baron
Lieutenant Commander – John Marshall McCammon
2nd Lieutenant Commander – Michael Joe Schmid
Adjutant – David L. Bohmfalk
Chaplain – Ronald Edward Bohmfalk
Sergeant-at-Arms – Warren Searson
Webmaster – Matt West
The following officer descriptions are found in the SCV Camp Officer Positions (SVC Camp Handbook 2012 Ed.)
Commander: The commander has a unique responsibility to lead, encourage, assist, guide, maintain esprit de corps, and above all, to work to achieve harmony within the camp. While an SCV camp is a democratically run organization, the camp commander does have the overall responsibility for the camp he has been elected to serve. The commander presides at all meetings or otherwise designates his subordinate officers to do so. He is nominated for office by a nominating committee, or from the floor. He will appoint all non-elected officers and all necessary committees and will perform such other duties as are usually incident to the office. He will fill all vacated offices occurring during his administration until the next election of officers, with the advice and consent of the camp executive council.
Lieutenant Commander: His authority is second only to the commander. He presides in the absence of the commander. Upon the resignation or death of the commander, the Lieutenant Commander automatically becomes commander for the un-expired term. He usually chairs the Programs Committee. He represents the commander at all memorial services when the commander is not present. The Lieutenant Commander is also a member of the camp executive council.
Second Lieutenant Commander: The Second Lieutenant Commander is not a required position, but is a position developing the future leadership of the camp and possible future camp commander. He serves at the direction of the commander and usually chairs the membership committee. He is authorized to represent the camp whenever the above officers cannot be present. However, he does not have the authority to speak for the commander or the camp unless given that authority by the commander. Some very large camps may even choose to have a Third and Fourth Lieutenant Commander to ease the burden of the above officers.
Adjutant The Adjutant may serve more than one term and a good one should be encouraged to continue in his post. The duties and responsibilities of Adjutant include those duties performed in many organizations by secretary, treasurer and registrar. In many camps a treasurer, a secretary, a genealogist or several other positions may assist the adjutant. His position is the most critical for the camp's continued growth and administrative responsibilities. An individual who procrastinates should not be considered for this office. This office and its complexities require an entire section of its own. Details are therefore contained in Section 7 for the adjutant's position within the camp.
Chaplain: A man with strong religious convictions usually fills this office. He will open and close all meetings with an invocation and a benediction. He serves at various memorial services and funerals. He should have the responsibility to send get-well cards to the sick. He should report to the camp on the condition of members and needs during their illnesses and recuperation. The Chaplain should order flowers for the deceased, at the camp's expense and with the approval of the Camp's Executive Council. He must also prepare a report of death for each deceased member and forward this to the Chaplain-in-Chief.
Sergeant-at-Arms He is responsible for maintaining order and decorum in the meeting place. The Sergeant-at-Arms will also serve in parades as the color sergeant and attend memorial services, firing demonstrations, and at other camp events.


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Casteel Creates Comfortable Climate for Clients and Employees
This article is number six in a series of profiles of the Cobb Chamber's 2015 Top 25 Small Businesses of the Year. Check back with Chamber Ink everyday in May for a new profile on a different Top 25 Business. We will wrap up the series on June 1 with the announcement of the 2015 Small Business of the Year.
You might think it's all in the name – heating, cooling, plumbing and electrical – but with Casteel it's really so much more. Casteel Heating, Cooling, Plumbing and Electrical's company culture prides itself on having a true family atmosphere by increasing employee morale and bringing employees together.
Listening to feedback from customers and employees, Casteel has been making significant changes in every department to fuel growth and profits in a down industry. By implementing the new changes the company has seen a 55 percent increase in sales revenue, a 40 percent increase in internet marketing leads and a 40 percent increase in staff and payroll over the last six years.
Facing the outside forces of mild temperatures and an even cooler economy, Casteel chooses to focus tirelessly on improving customer service, serving them rather than selling to them. Casteel allows each of their employees to become top craftsman, providing over 120 hours of training per year for each employee.
Business profile:
Owner: Bob Casteel and John Hillis
Industry: HVAC, Plumbing, Electrical
Year Established: 1998
Location: Marietta
Number of Employees: Full-time: 130, Part-time: 8
Percentage of Growth in 2014: 24%
Did You Know?: In the past 10 years the number of qualified technicians in the workforce has dropped by 50 percent. To fill this void, Casteel has initiated a "bring a buddy to work" and a "border to border" program to recruit and train qualified technicians.
Website: www.casteelair.com
Social media:
Facebook: https://www.facebook.com/CasteelAir
Twitter: @casteelair
Comments are closed.


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Gimblett Gravels Vineyard Syrah 2012 (Museum Release)
Style Number: 12CRSYGGCV
- Dispatches in 1-2 working days. ID required on delivery.
Craggy Range is an iconic family owned winery established in 1997 and situated in the shadow of the spectacular Te Mata Peak in the premium wine growing area of Hawke's Bay New Zealand.
This beautifully mature Syrah from the 2012 vintage has been aged slowly in the perfect conditions of our winery cellar and is drinking beautifully now. Produced from the gravelly soils of the Gimblett Gravels appellation in Hawkes Bay, this distinctive Syrah shows an aromatic lift of floral and pepper aromatics with lushness and elegance on the palate. Highly recomended.
Shipping info
Dispatches in 1-2 working days from Craggy Range via signed courier. A tracking link will be emailed once dispatched. Please be aware that the recipient will be asked for age verification photo ID on delivery of this product.Liquor Licence
This item is not available for change of mind exchanges. See Delivery & Returns for more information.


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Separate names with a comma.
Discussion in 'Sold/Expired Classifieds' started by cromanos, Dec 8, 2010.
Can you post a link or GB user name?
Re: RFB Quad rails
Re: RFB Quad rails
We are not an extension of GB and this forum is not maintained to point people there. Without regard to the current bid there or elsewhere, if you are offering them for sale here, you need a posted price. Please read and follow the Trading Post Rules.
The rules weren't clear to me on that aspect ...
and then you delete the original post. rather than just follow the rules.
I assumed that's what I should do,
since the moderators were saying my post didn't follow the rules.
I would be more than happy to follow the rules, if I knew what they were.
Before you react to that last statement, Yes I read the rules, a couple of times through
(it's only a paragraph).
The rules don't mention anything about posting links outside the forum.
I've watched this forum for about a year, and been a member for a couple of months, after
I got my RFB, and had some useful input. As I have read this forum, appros every third posting has
outside links embedded.
How am I supposed to follow a rule that are not written?
rules are written
they were in the email all members recieve when they sign up
have a good day,


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Hello, everyone!
My name is Deborah Pingkan. I live in Seattle, and I am currently in college studying electrical engineering. I like nice things. I like foods, poems, flowers, paintings, music, and a little bit of everything. I also shamelessly have a real obsession over horror movies and supernatural things because I find it interesting to know the fact that although something is unseen, doesn't mean it's not there, right? Isn't it cool to think about?
I also like to listen to music. I pretty much listen to music almost 24/7, and I do feel like I function better when I am listening to music, like what I am doing right now while writing this. I am more into rock and punk music (okay, to begin with, lemme tell yall that emo is NOT dead! LOL) because I feel like rock music is very uplifting for me, and it helps me a lot to get through all the crazy workload on a daily basis. Yet still, sometimes I listen to a 'slower' music like RnB or Indie music. I find it very relaxing, and it helps to keep my spirit up when I am doing chores. What kind of music do you guys like? Do you think music has a great impact on your life?
Besides all of that, I also like to read and watch movies on my free time. I also do hiking sometimes, when I have the time and if the weather is nice. I pretty much will read anything that caught my attention. From biographies, poems, history articles, to scientific journals, I think reading is also one of the forms of self-care for me because somehow it is very soothing and relaxing to the soul. Same goes to watching movies. Some of my favorites are Fight Club, Wicker Park, Leon The Professional, Pulp Fiction, Se7en, The Silence of The Lambs, and Insidious. I tend to lean on older movies. What do you guys like to do on your free time? Let me know on the comment section!
So, why did I choose "Reveriends" as my blog name? Because.. well, it's a combination of "Reverie" and "Ends." Which basically means the end of a reverie. I always have trouble with focusing on something, and I always (literally) daydreaming every single day. I don't know why, but I always find myself drowning in my own thoughts. So, that's why I named this blog "Reveriends," because I think I can distract myself for a while or prevent myself from having a reverie, by writing on this blog. I will also express some of my thoughts here and personal experiences. So, that's how I got the name.
I hope you can enjoy reading my blog, and I hope to see you again soon!


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Infinix Mobility, the famous manufacturer of widely popular affordable phone line Infinix Mobile, is going to release another Infinix Zero smartphone in November 2017. A younger brother to everyone's favorite Infinix phones Zero 4 and Zero 4 Plus, the Infinix Zero 5 will definitely impress us with its powerful fats processor, long battery life, and improved cameras!
We managed to find out the specs of the new legendary device – so simply read this Infinix Zero 5 review to be aware of all the details!
Get the latest news first with Jiji!
1. Infinix Zero 5 specs
- Screen: 5.98' with1920 x 1080 resolution;
- Chipset: MediaTek Octa-Core Helio P25 with the frequency of 2.6GHz;
- OS: Android 7.0;
- 6GB RAM and 64GB ROM!
- Dual SIM Card Support: Micro SIM card + 1 Micro SIM card;
- Main Camera: Dual 12.0MP + 13.0MP
- Front Camera: 16.0MP
- Sensors: Accelerometer, Hall Sensor, Ambient Light Sensor, Gyroscope, Gravity Sensor, E-Compass.
- Bluetooth: 4.2.
2. Infinix Zero 5 features: Design
This large-screen device features trendy narrow bezels and a polished metal look. The device offers various color variations to satisfy all tastes.
3. Software
The custom UI XOS Hummingbird v3.0 based on Android 7 Nougat will take the place of XOS Chameleon on all the Infinix Zero 5 phones.
4. Performance
Zero 5 will be equipped with 2.6GHz Octa-core processor and 6GB RAM to ensure fast speed and efficient multitasking. The phone feature 4350 mAh battery that will last you for a very long time even under heavy usage.
5. Memory Storage
The most mind-blowing feature of the new Zero 5 is its impressive 64GB of internal storage. So the users of the brand-new device won't even have to think about any SD cards.
6. Camera
Infinix new phone is also the first to feature powerful 12MP and 13MP back cameras located above the fingerprint scanner on the back cover. They are sure to produce clear and vivid pictures for you! The 16MP front camera packs deliver sharp images at the single click of a button.
7. Battery
Infinix Zero 5 packs an amazing 4350 mAh battery with a quick charge feature. This is a much-awaited upgrade after the Zero 4's disappointing 3200 mAh battery.
8. Infinix Zero 5 price in Nigeria
Are you impatient to find out how much is Infinix Zero 5?
Well, Infinix Zero 5 price is said to be about $300. The price in Nigeria should be around N118,000 – N120,000 – it's just 28,000 higher than Infinix Zero 4.
9. Infinix Zero 5 release date
The smartphone will be released on November 22, 2017.
Infinix Zero 5 Unboxing and First Impressions
Infinix has just launched their new flagship, the Zero 5. We have with us the Zero 5 Pro, a higher spec'd version of the Zero 5. This is our unboxing and first impressions, our review shall follow later.
Install free updated Jiji app now – shop online on Jiji in the best way!


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Learning does not stop at the closing bell of the school day! Cornerstone Connections Project youth at New Haven Middle School (CCP New Haven) enjoy experiential learning activities along with the opportunity to develop assets through mentoring, academic enrichment, life skills development, and community building. Youth in grades 6-9 are welcome to join CCP New Haven in the cafeteria from after school until 5:30 p.m.
New Haven Middle School
Site Phone 260-245-1280
900 Prospect Ave, New Haven, IN 46774
Monday-Thursday Afterschool-5:30 p.m.
Youth in 7th & 8th grades are welcome at CYC Monroeville for weekend hours [Monroeville Friday 6-10 p.m.]
Color Code Key:
Blue: CCP New Haven
Green: CCP Woodlan


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"Sorry we're no dookin cats nae mair, no even wee baudrons' – Dave over there's no in fancy dress – it's first aid."
baudrons: affectionate name for a cat, happy cat (re: mimic of the purring sound).
"Sorry we are not dipping cats any more – not even little friendly types – Dave over there is not in fancy dress, it is treatment from the first aid station."
Not that I condone mistreating animals in such a way.
I'm even appalled by people dressing their pets in coats and shoes.
Are they mad? And monkeys instead of children?


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Below is the uncorrected machine-read text of this chapter, intended to provide our own search engines and external engines with highly rich, chapter-representative searchable text of each book. Because it is UNCORRECTED material, please consider the following text as a useful but insufficient proxy for the authoritative book pages.
32 DRINKING WATER AND HEALTH assessed. The additional studies recommended in the last review are still needed. Despite extensive knowledge concerning the metabolism of 1,2-dichlo- roethane, there is still a need to know the comparative pharmacokinetics in different species, including humans. The knowledge that 1,2-dichloroe- thane has been shown to have both mutagenic and carcinogenic properties in animals provides further reason to obtain these kinds of data following oral exposure in order to develop better estimates of the risk to humans exposed to low levels. 1, 1-DICHLOROETHYLENE ethene, 1,l~ichior~ CAS No. 75-35-4 H2 C = CC12 1,1-Dichloroethylene is commonly called vinylidene chloride. This sub- stance is used primarily as an intermediate in the synthesis of copolymers slated for food-packaging films and coatings. It is also used in the synthe- sis of 1,1,1-trichloroethane. This volatile liquid has a boiling point of 31.7°C, and it is practically insoluble in water, having a solubility of only 0.04 w/v (400 mg/liter) at 20°C (Hardie, 1964~. It has been found in drinking water in concentrations as high as 0.1 ~g/liter (U.S. Environ- mental Protection Agency, 1975b). In 1976, 120 million kg were produced in the United States; 50 million kg were used as an unisolated intermediate (International Agency for Research on Cancer, 1979a). The threshold limit value is 10 ppm (40 mg/m3) (American Conference of Governmental In- dustrial Hygienists, 1981~. METAB OLI SM Orally administered 1,1-dichloroethylene is rapidly and completely ab- sorbed in rats (Jones and Hathway, 1978a; Putcha et al., 1982; Reichart et al., 1979~. Following distribution, the highest concentrations are found primarily in the liver and kidneys (Jones and Hathway, 1978a~b; McKenna et al., 1978~. At low doses a major route of elimination is exhalation of the parent compound (Chieco et al., 1981; Jones and Hathway, 1978b; Rei- chert et al., 1979~. lithe exhaled metabolic product is carbon dioxide. At higher doses, the parent compound predominates (Jones and Hathway, 1978a,b; McKenna et al., 1978~. The compound is metabolized to a number of metabolites, presumably
Toxicity of Selected Contaminants 33 through the formation of an epoxide (Greim et al., 1975; Henschler, 1977; Henschler and Bonse, 1978; Leibman and Ortiz, 19771. Jones and Hathway (1978a) reported that 80~o of an intragastrically administered 0.5 mg/kg dose appeared as urinary metabolites, whereas only 33% of a 350 mg/kg dose was metabolized. At the higher dose, 375to of the urinary metabolites were identified as thiodiglycolic acid and 48% as an N-acetyl- S-cysteinyl derivative. McKenna et al. (1978) observed that 78% of a single oral 1 mg/kg dose was accounted for in metabolites found in the urine and feces, that 21 To was exhaled as carbon dioxide, and that from 1~0 to 3~0 was exhaled as unchanged 1,1-dichloroethylene. After the administration of a 50 mg/kg dose, 19% was exhaled unchanged by fed rats and 29% by fasted rats. The two major urinary metabolites excreted within 25 hours following the ad- ministration of 1 mg/kg to fed rats were identified as thiodiglycolic acid (22~o of the metabolites) and 5-~2-hydroxyethyl)-N-acetylcysteine (13% of the metabolites). Reichert et al. (1979) observed dose-dependent metabo- lism: 1.3% was exhaled unchanged following an oral dose of 0.S mg/kg, but 16.5% was exhaled after 50 mg/kg. Renal excretion was approxi- mately 43% in both cases, but biliary excretion amounted to 16~o after the low dose and 8% after the high dose. Thiodiglycolic acid was the main urinary metabolite, accounting for approximately Who. Other metabo- lites, including chloroacetic acid, dithioglycolic acid, thioglycolic acid (Jones and Hathway, 1978a), N-acetyl-5-~2-carboxymethyl) cysteine, and methylthio-acetylaminoethanol (Reichert et al., 1979) have also been iden- tified in rat urine. In in vitro studies with rat liver microsomes, monochlo- roacetate and dichloroacetaldehyde were identified as metabolites (Costa and Ivanetich, 1982a,b). Mice given an oral dose of 50 mg/kg metabolized the compound to a greater extent than did rats; they exhaled to un- changed in contrast to the 28~o exhaled by rats (Jones and Hathway, 1978b). Dithioglycolic acid (23~o of the dose) and the N-acetyl-S-cysteinyl acetyl derivative (Woo of dose) were the primary metabolites. HEALTlI ASPE CTS Observations in Humans No definitive studies in humans have been reported. Early studies of work- ers exposed to traces of 1~1-dichloroethylene cannot readily be evaluated since the major compound to which the workers were exposed was vinyl chloride (Kramer and Mutchler, 1972~. Ott et al. (1976) examined the health of 138 employees exposed to 1,1-dichloroethylene where vinyl chlo- ride was not a copolymer. Time-weighted averages for exposure ranged
34 DRINKING WATER AND HEALTH from less than 10 ppm to greater than 50 ppm (40-198 mg/m31. The inves- tigators observed no alterations in results of clinical laboratory tests, in- cluding hematological tests, urinalyses, and tests for respiratory functions, performed on these workers. There are no data on long-term exposures of large numbers of human beings. Observations in Other Species Acute Effects The most commonly reported toxic effect of 1 ,1-dichlo- roethylene is hepatotoxicity. Jenkins et al. (1972) reported that a single oral 100 mg/kg dose of 1,1-dichloroethylene in corn oil given to rats caused a decrease in liver glucose-6-phosphatase and an increase in alkaline phos- phatase activity but did not cause elevations in plasma alkaline phospha- tase and alanine aminotransferase. These plasma enzymes were elevated following doses of 300 mg/kg and 500 mg/kg. Establishing a dose-response relationship for the oral lethality of 1,1- dichloroethylene in rats has presented some difficulties (Andersen et al., 1979~. For large ~ ~ 200 g) male rats, the dose-response reached a plateau at about 400 mg/kg. Immature rats (73 g) were more sensitive: there was an almost 1005to lethality at doses of 200 mg/kg, but there was an apparent decrease in lethality when dose levels greater than 200 mg/kg of the com- pound were administered. Smaller rats also responded with a greater in- crease in hepatotoxicity, as assessed by serum enzymes following a 50 ma/ kg dose of 1,1-dichloroethylene in corn oil (Andersen and Jenkins, 1977~. Plasma aspartate aminotransferase in these animals (100-110 g) was ele- vated at a dose of 25 mg/kg but not at 12.5 mg/kg. In one study, female rats were observed to be less sensitive to injury than were males (Andersen and Jenkins, 1977), but in another, female rats were reported to be more sensitive (Jenkins et al., 1972~. A confounding factor in the studies of 1 ,1-dichloroethylene has been the influence of fasting prior to administration of the compound. Jaeger et al. (1974) exposed rats by inhalation to various concentrations of 1,1-dichlo- roethylene and estimated that the minimum lethal concentration was 200 ppm (794 mg/m3) for fasted rats and 10,000 ppm (39,700 mg/m3) for fed rats. Serum alanine aminotransferase levels were elevated at 150 ppm (595 mg/m3) in fasted rats, but a level of at least 2,000 ppm (7,940 mg/m3) was needed for the same effect in fed rats. This striking difference was related to the effect of fasting on hepatic glutathione concentrations. The importance of fasting was also observed histologically (Reynolds and Moslen, 1977; Reynolds et al., 1975~. Hepatic lesions occurred earlier and were more extensive in fasted rats exposed to 200 ppm (794 mg/m3) of 1,1-
Toxicity of Selected Contaminants 35 dichloroethylene for 4 hours than were observed in fed rats subjected to the same exposures. These lesions included nuclear changes, swollen and rup- tured mitochondria, and midzonal necrosis. Other effects have been reported. Harms et al. (1976)observed in rats that a 0.5 ml/kg dose administered intraperitoneally caused an increase in bile-duct pancreatic fluid flow but had little or no influence on hepatic bile flow. Jenkins and Andersen (1978) reported the occurrence of nephrotoxicity in rats, based on elevations in blood urea nitrogen (BUN), which generally parallel hepato- toxic responses. The doses needed to elicit this response were higher than those needed to induce hepatotoxicity; a dose of 400 mg/kg caused elevations in BUN in fasted but not in fed rats. Chronic Effects Prendergast et al. (1967) exposed rats, guinea pigs, dogs, rabbits, and monkeys by inhalation to 5, 15, 20, and 45 ppm (20, 60, 80, and 180 mg/m3) 1,1-dichloroethylene for 90 days. At the highest level, 7 of 15 guinea pigs and 3 of 9 monkeys died. Dogs and monkeys lost weight, and rats gained less weight than did the controls. In the livers, there was fatty metamorphosis, focal necrosis, hemosiderin deposition, bile duct proliferation, and fibrosis. These signs were most severe in the dog. The morphologic changes were accompanied by elevations in liver al- kaline phosphatase and serum aspartate aminotransferase, but serum urea nitrogen levels were not elevated. In the rat kidneys there was nuclear hypertrophy of the tubular epithelium. At 20 ppm, weight losses were ob- served in rabbits, dogs, and monkeys, and 3 of IS guinea pigs and 2 of 3 monkeys died, but no defined histopathological changes were observed. At 15 ppm, 3 of 5 guinea pigs died, and the monkeys and rats had poor weight gain. At.5 ppm, 2 of 45 rats, 2 of 4S guinea pigs, and 1 of 21 monkeys died, but no signs of toxicity were observed. No histopathological lesions were found in the liver, and serum enzyme levels were normal. In the control group, 7 of 304 rats, 2 of 314 guinea pigs, none of 34 dogs, and 1 of 57 monkeys died. Quast et al. (1977) exposed male and female Sprague-Daw- ley rats to 60, 100, or 200 ppm (6, 10, or 19 mg/kg) daily for 90 days. No changes were obser~red in body weight gain, hematological indices, urine analysis, BUN, serum alkaline phosphatase, serum alanine aminotrans- ferase, gross patholog~y, or organ weights. Hepatocellular vacuolization was seen in the animals receiving 200 ppm. Norris (1977) reported that no adverse effects were observed in dogs given 1,1-dichloroethylene in doses of 6.25, 12.5, or 25 mg/kg for 90 days. This assessment was based on clinical observation, body weights, and gross and histopathological examination. Rampy et al. (1977) exposed male and female Sprague-Dawley rats to 1,1-dichloroethyJene at concentrations of 68, 106, and 220 mg/liter in drinking water. They examined the groups at 6, 12, 18, and 24 months of
36 DRINKING WATER AND HEAlTH exposure. There were no consistent changes in body weight gain, hemato- logical indices, urinalysis, and nonprotein sulfhydryl groups in the liver and kidneys. There was slightly higher mortality than in the controls for the males in all three treatment groups, but this was not related to dose and was not observed in the females. No differences were observed in organ weights except for a decreased kidney to body weight ratio in the males at the lowest dose levels at the 90-day sacrifice. The only histopathological change noted was a vacuolization of hepatocytes at the 220 mg/liter expo- sure. 1,1-Dichloroethylene was administered by gavage in corn oil to Fischer 344 rats and B6C3~ mice S times per week for 13 weeks at levels of 0, S. IS, 40, 100, or 250 mg/kg bw (National Toxicology Program, 1982b). Cen- trilobular necrosis was observed in three rats, which died at the highest level of exposure. Cellular Apia, characterized as altered nuclear/cytoplas- mic ratios, megalocytosis, basophilia, clear cells, and an increase in binu- cleated cells, was seen in the rats given the turo highest dose levels. Foci of cellular alteration were observed in rats receiving the 5 and IS mg/kg doses, but not in those at the higher doses. In the mice, there was considerable mortality at the higher doses, and a dose-related decrease in body weight was observed in the males. Dose-related hepatic lesions were observed but were minimal at 5 mg/kg. In the same study, 1,1-dichloroethylene was administered for 104 weeks by garage in corn oil at levels of 1 orS mg/kg bw (to rats) and 2 or 10 mg/kg bw (to mice) (National Toxicology Program, 1982b). There were no adverse effects on body weight or sundial of the rats, and no compound-related clinical signs were observed. The only lesion of possible significance reported was a dose- dependent increase in chronic inflammation of the kidney, but this lesion was also present in the controls. In mice, the body weights of the treated males were lower than those of the controls, but in both males and females there were no clinical signs of toxicity or significant differences in survival. Mutagenicity 1,1-Dichloroethylene was found to be mutagenic In the Ames Salmonella assay by the following investigators: Bartsch et al. (1975, 1979), Jones and Hathway (1978c), and Simmon et al. (1977~. These assays were performed in desiccators. A variety of mammalian metabolic acti~ra- tion systems elicited or enhanced mutations in one or more of the Salmo- nella base~pair substitution mutants. Activating systems were: uninduced kidney and liver S9 fractions from male albino mice; Aroclor 1254-induced kidney and liver S9 fractions from male Sprague-Dawley rats; a presumed phenobarbital-induced S9 liver fraction from humans; phenobarbital-in- duced liver S9 fractions and phenobarbital-induced and uninduced kidney and lung S9 fractions from OF-1 mice; and uninduced S9 fractions from
Toxicity of Selected Contaminants 37 the liver, kidney, and lung of female BD VI rats. Preparations that failed to induce mutations were uninduced liver S9 fractions from marmosets, humans, and male rats. 1,1-Dichloroethylene did not induce chromosome breakage in Chinese hamster DON-6 cells when tested at concentrations of 3 X 10-3 and 3 X 10-2 mM. It could not be determined from the data whether or not the compound induced toxic effects (Sasaki et al., 1980~. No increase in 8-azaguanine- and ouabain-resistant colonies was observed when Chinese hamster V79 cells were exposed in desiccators to to and loo 1,1-dichlo- roethylene vapor in air for 5 hours (Drevon and Kuroki, 1979~. Anderson et al. (1977) exposed male mice by inhalation to 50 ppm (198 mg/m3) for 6 hours per day for 5 days prior to mating and found no evi- dence of dominant lethality. Short et al. (1977) reported similar findings in rats. Mutagenic activity was observed in the multiple end point E. cold K12 strain when assayed in suspension at a concentration of 2.5 mM in the presence only of liver S9 fraction derived from phenobarbital-pretreated male mice (Greim et al., 1975~. Both point mutation and mitotic gene con- version were observed in Saccharomyces cerevisiae D7 in the presence of liver S10 fraction obtained from male mice pretreated with Aroclor 1254 (Bronzetti et al., 1981~. They also observed mutagenic activity in a mouse host-mediated assay with S. cerevisiae D7 after the animals were Savaged with 1,1-dichloroethylene in corn oil. The data indicate that 1,1-dichloroethylene is mutagenic in several mi- crobial mutagenicity assays and in a mouse host-mediated microbial assay. Negative results were obtained in an in vitro mammalian mutagenicity as- say and in a mouse dominant lethal study. No chromosome breakage was observed in an in vitro study with Chinese hamster cells. Carcinogenicity Evidence for a carcinogenic effect of 1,1-dichloroeth- ylene was obtained in studies of mice (Maltoni, 1977~. Of the 300 male and female Swiss mice exposed to 25 ppm (100 mg/m3) of the compound 4 hours/day, 5 days/week for 52 weeks, 25 (8.3~o) had developed kidney adenocarcinomas at the end of the experiment (98 weeks). No such tumors were found in controls. No tumors were found in rats or hamsters exposed to higher concentrations of 1,1-dichloroethylene for the same length of time. In another study, mice and rats were exposed to 1,1-dichloroethylene at 55 ppm (220 mg/m3), 6 hours/day, 5 days/week. The experiment was ter- minated after 12 months (Lee et al., 19781. Among the 70 male and female exposed mice, six bronchial lung tumors were found; the earliest of the tumors appeared between 4 and 6 months, and the latest after 12 months.
38 DRINKING WATER AND HEALTH Three of the 70 mice had hepatic hemangiosarcomas. Because of the small number of tumors and the low incidence, it was questionable whether these findings were related to 1,1-dichloroethylene exposure. In 2 of 35 male rats, hemangiosarcomas were found in the mesenteric lymph nodes or in subcutaneous tissues. Despite the low incidence, the investigators believed that these tumors were related to the 1,1-dichlorethylene. 1,1-Dichloroethylene was found to produce skin tumors when applied once to mouse skin, followed by repeated treatments with phorbol myris- tate acetate. When given alone, it did not produce tumors when applied topically or by subcutaneous injection. Thus, 1~1-dichloroethylene can be regarded as an initiating agent for mouse skin (Van Duuren et al., 1979~. Several studies failed to demonstrate significant carcinogenic activity of 1,1-dichloroethylene. In a study by Viola and Caputo (1977), Wistar rats were exposed to 1,1-dichloroethylene by inhalation to 200 ppm (792 mg/m3) for 5 months. The exposure was then reduced to 100 ppm (396 mg/m31. Both exposures were administered 4 hours/day, 5 days/ week. The second exposure was continued for the lifetime of the animals. There was no difference in the incidence of tumors between the exposed and control rats. The experiment was repeated with Sprague-Dawley rats, which were exposed to 1,1-dichloroethylene in concentrations of 100 or 75 ppm (396 or 297 mg/m3~. At the time of reporting, Viola and Caputo (1977) could not conclude that 1,1-dichloroethylene was carcinogenic. Male and female Sprague-Dawley rats were also exposed for their lifetime to concentrations of 1,1-dichloroethylene ranging from 60 to 200 mg/liter in drinking water. The authors reported no increase in tumor incidence, a conclusion based on gross tumor count only. The same laboratory con- firmed that exposure to 1,1-dichloroethylene at 10 to 40 ppm (40-160 ma/ m3) in air (6 hours/day, 5 day/week for 18 months) was not carcinogenic to Sprague-Dawley rats (Rampy et al., 1977~. 1,1-Dichloroethylene monomer was dissolved in olive oil and given orally to 24 pregnant female BD IV rats at a dose of 150 mg/kg on the 17th day of gestation. Their offspring (89 males and 90 females) then received weekly 50 mg/kg doses of 1,1-dichloroethylene, which was administered in olive oil by stomach tube. Animals were killed when moribund, and approxi- mately one-half of the animals survived for 130 weeks. In the treated ani- mals, there was an increased incidence of liver tumors. In treated males, there were more meningiomas than in the controls. However, the total number of tumor-bearing animals was the same for exposed animals and controls. There was some question whether the dose used in this experi- ment was the maximum tolerated dose (Ponomarkov and Tomatis, 1980~. A similar problem was encountered in a study commissioned by the Na- tional Toxicology Program (1982b). In a 104-week study, Fischer 344 rats were given 1 or 5 mg/kg doses of 1,1-dichloroethylene 5 times per week;
Toxicity of Selected Contaminants 39 B6C3F~ mice received 2 and 10 mg/kg 5 times per week. In this bioassay, there was no evidence that 1,1-dichloroethylene was carcinogenic for either the rats or the mice. However, there was some doubt as to whether a maxi- mum tolerated dose had been used in this study. To date, there has been no evidence that 1,1-dichloroethylene is carcino- genic in humans (Infante, 1977~. However, the only epidemiological study found by the committee was based on a small population of 139 people exposed to measured levels of 1,1-dichloroethylene where vinyl chloride was not used as a copolymer (Ott et al., 1976~. A more recent analysis of the data did not enable investigators to draw definite conclusions (Ap- feldorf and Infante, 1981~. The committee's review indicated that the information on 1,1-dichloro- ethylene is not sufficient for a definite conclusion to be reached about its ability to induce cancer in laboratory animals or humans. Teratogenicity Murray et al. (1979) subjected rats and rabbits to inha- lation exposures of 1,1-dichloroethylene in concentrations as high as 160 ppm (635 mg/m3) for 7-hour periods during days 6 through 18 and 6 through IS of gestation, respectively. Maternal toxicity was observed in both species. No increased general malformation rate was found, but wavy ribs and delayed ossification were more frequent in rat fetuses exposed to 1,1-dichloroethylene at 80 and 160 ppm. Alumot et al. (1976) fed 1,1-di- chloroethylene to pregnant rats at 200 ppm in their diets on days 6 through IS of gestation. They observed no differences between the exposed fetuses and controls. The same investigators also fed rats doses as high as SOO ppm in feed over a 2-year period and found no alteration in fetal mortality or weight when litters were examined after birth. Approximately 60~o to 70% of the substance was estimated to have been consumed. 1,1-Dichloroethylene was reported to be nonteratogenic when given to rats in drinking water at 200 mg/liter or when administered by inhalation to rats and rabbits at 0, 20, 80, or 160 ppm (0, 80, 240, or 580 mg/m3) for 7 hours/day on days 6 to IS of gestation in rats and days 6 to 18 of gestation in rabbits (Norris, 1977~. The data indicate that 1,1-dichlorethylene is not teratogenic to mice, rats, or rabbits. There are no data from which its effects in humans can be judged. CONCLUSIONS AND RECOMMENDATIONS Suggested No-Adverse-Response Level {SNARL} Chronic Exposure The following calculation for a chronic SNARL is based on noncarcinogenic effects only. Rampy et al. (1977) administered
40 DRINKING WATER AND HEALTH 1,1-dichloroethylene in the drinking water of male and female rats for as long as 2 years. At 220 mg/liter, but not at 106 ppm, vacuolization of the hepatocytes was observed. At 106 mg/liter, the mean daily consumption for males was 10.0 mg/kg and for females it was 12.6 mg/kg. However, a carcinogenesis bioassay of 1,1-dichloroethylene indicated that 10 mg/kg causes slight hepatotoxicity in mice (National Toxicology Program, 1982b). This was not observed at the 2 mg/kg dose. An uncertainty factor of 100 was assumed on the basis of the above study. Assuming that a 70-kg human consumes 2 liters of water daily, that 20~o of the exposure of most individuals would be from drinking water, and a factor of 5/: to correct from a 5- to 7-day weekly exposure, one may calculate the SNARL as: 2mg/kg X70 kg XO.2 5 100 X 2 liters X 7 = 0.10 mg/l~ter. If present in drinking water, 1,1-dichloroethylene would be rapidly and completely absorbed. At the low levels expected to be present, dose-depen- dent kinetics involving saturation of the metabolic pathways would not oc- cur, so that nearly all of the compound would undergo metabolic conver- sion. Studies in animals suggest that the principal target organs in humans would be the liver and, to a lesser extent, the kidney. 1,2-DICHLOROETHYLENE cis (ethene, 1,2~ichlor~(Z)- CAS No. 156-59-2 bans (ethene, 1,2~ichlorm<E)- CAS No. 156-60 5 ClHC = CHCl 1,2-Dichloroethylene exists in both the cis and bans founts. Both of these compounds are used, alone and in combination, as solvents and chemical intermediates. Their solubility in water is low. The solubility of cis- 1,2-dichloroethylene is 0.35 g/100 g (3,500 mg/liter) and that of trans-1,2- dichloroethylene is 0.63 g/100 g (6,300 mg/liter) at 25°C (Hardie, 1964~. Both isomers have been found in drinking water (U.S. Environmental Pro- tection Agency, 1975b). The maximum concentrations found were 16 ~g/ liter for the cis isomer and 1.0 ~g/liter for the isomer. METAB OLI SM Using an isolated, perfused rat liver preparation, Bonse et al. (1975) found that both isomers were metabolized to the same metabolites dichlo-


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Last night I got on the bike trainer and watched an episode of The Biggest Loser. The only season I've ever watched of The Biggest Loser was Season 5 when Ali won (I believe the first woman winner).
I have mixed feelings about The Biggest Loser. I like the show; I think ANYTHING that inspires people to work out and get healthy is amazing. I guess my problem with the show is that it's not realistic for EVERY DAY PEOPLE like me. I couldn't go to essentially a Fat Camp. I work, I need to pay my bills. And not only that, most people can't spend 5+ hours a day working out with a personal trainer. No wonder they lose immense amounts of weight so quickly! I feel like someone wanting to lose weight on their own will be disappointed by their smaller — and slower — results. Despite those reservations, I do like show and think it's amazing that people can lose that much! What does everyone else think of the show?
I did 50 minutes on the bike trainer and then spent about 6 minutes stretching and doing my Foam Roller. I burned 451 calories.
The Foam Roller kind of hurt last night! I worked my shins and while I had no pain in my shins beforehand, I noticed that while I was rolling my shins felt really tender! Weird!
We had a friend come over for dinner last night. Michael made his famous Mac n Cheese! Soooo good!
His Mac n Cheese is my favorite. I've never had anything better than this!
Our friend brought some broccoli and I steamed it.
Dinner really hit the spot! Dessert was my other favorite thing: Skinny Cow ice cream sandwiches! They are huge and only 140 calories?!
This morning (Wednesday) I had Scottish Oats for breakfast and my lunch is a ham sandwich with fresh veggies:
I've noticed lately that I am craving REAL FOOD. I attribute it to the bike training that I've been doing. I just want to eat fruit, veggies and MEAT! So strange!
Kat over at Granola + Pancakes (http://granolapancakes.blogspot.com/2010/04/tagged-tuesday.html) tagged me in her post, so here goes! 🙂
1. Who is your style icon? Um…no idea!
2. What is your favorite book? I'd have to say "Eat Pray Love." I read it at a time in my life when I really related to it and I'm looking forward to the movie!
3. Favorite Party Theme? My friends used to throw a great Halloween Party called "Heaven and Hell". Upstairs, she was dressed as an angel and the decor and theme was heaven, downstairs he was dressed as a devil with the appropriate decor. It was fun!
4. Favorite Outdoor Activity? HIKING! And biking is a close second. Oregon has lots of fantastic, picturesque hiking!
5. Something You Cannot Live Without? Probably my iphone. 🙂
6. Living Person You Admire? Probably my friend Robyn. She joined the Army at age 36ish and kicked ASS in all her PT competitions!
7. Greatest Fear? Gaining back all my weight.
8. Favorite Meal? Either Mexican food or sushi.
9. Which Talent You Would Most Like To Have? The ability to speak multiple languages. And be able to do the Butterfly Stroke!
10. Greatest Achievement? Losing 110 pounds on my own.


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1 The places of London
2 Transform Crownd Castle Palace GalleryPartCapitalHouseAboutAbbeyFoundproud
3 The Tower of London Westminster Abbey Buckingham Palace The National Gallery Big Ben Hyde Park The Tower of London Piccadilly Circus
5 Close your eyes! Open your eyes! Turn you eyes to the left, turn your eyes to the right. Your eyes up, your eyes down! Close your eyes! Open your eyes! Turn you eyes to the left, turn your eyes to the right. Your eyes up, your eyes down!
6 It is a beautiful Gothic building. It was a monastery and a Norman church for a long time. It was built in the 11th century and is famous for the Poets Corner. Many English kings and queens were crowned there Westminster Abbey
7 It is the official home of the English Queen. It was built in There are 600 rooms in the palace. It is like a small town with a police station, a hospital, a bar, a cinema, two sport clubs and a swimming-pool Buckingham Palace
8 Its one of the best picture galleries in the world. It is situated on the north side of Trafalgar Square and contains canvases of outstanding painters The National Gallery
9 Its a big clock in one of the towers. You can hear the sound of it every hour in London. They got their name after Sir Benjamin Hall Big Ben
10 It is a royal park since 1536 Its one of the most popular places of Londoners on hot summer days. Its famous for its Speakers Corner Hyde Park
11 William the Conqueror built it in the 11th century. It was used as a fortress, a state prison and an old castle. Many English kings and queens were imprisoned and beheaded there. Now it is a museum The Tower of London
12 Рефлексия
13 Thank you for the lesson Thank you for the lesson
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Indian pharmaceutical company Dr. Reddy's Laboratories is attempting to resurrect over-the-counter (OTC) pain reliever Doan's, through a new marketing campaign. Doan's is part of a multi-product portfolio developed by Novartis, sold to Ducere Pharma in 2013 and finally, acquired by Dr. Reddy's last year.
In addition to Doan's, Dr. Reddy's acquired the rights to another pain reliever, Myoflex, as well as other OTC drugs with indications ranging from heartburn to hemorrhoids. Dr. Reddy's will start their marketing push with a focus on three brands – Doan's, Bufferin and Nupercainal – eventually working their way towards promoting Cruex Nail Gel, Comtrex, and Myoflex.
Doan's was once a popular pain reliever for back pain, but the product has been off the market for over five years. In 1999, Novartis was charged by the Federal Trade Commission (FTC) for including unsubstantiated claims of superiority over other back pain treatments in their advertisements for Doan's.
Dr. Reddy's new national TV ad campaign for Doan's – which was launched two weeks ago – steers clear of making any controversial claims. Instead, the 15-second spot aims to remind older viewers of the heritage brand, and introduce younger viewers to both the oral and topical forms of the pain reliever drug.
"The brands have had high brand awareness in the past, so the challenge was, 'how do we bring it back to the current market, but also bring it to a new generation of potential sufferers?'" Lauren Schulz, director of OTC brand marketing at Dr. Reddy's, told FiercePharma.
Along with the TV ad campaign, the marketing push will include digital ads and a redesigned website. According to Schulz, awareness of the Doan's brand has already increased from 35 percent to 43 percent in eight test markets since the ad campaign began.
These are promising results for a notoriously competitive product category. Since its exit from the market around seven years ago, big-name brands such as Advil, Tylenol and Aleve have maintained their share of the lucrative OTC pain reliever market.
In 2016, the US market for topical pain relievers was $734 million, with sales of oral analgesics reaching $4.12 billion, according to the Consumer Healthcare Product Association. Dr. Reddy's will need to make a major investment in promoting Doan's to have a shot at capturing some of this market share.
"Dr. Reddy's invested in these assets to grow them," said Shultz. "They went after this portfolio specifically because it was brand names that people knew with room to grow, but had just been ignored."
You can watch the advertisement here.


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Behemoth 'Bartzabel' roasted coffee grains 500 g / 1 lb
Selected Arabica coffee grains from India, Chikmagalur region, freshly roasted. Low acidity and rich flavor which makes this coffee absolutely delicious, unique and rich in taste.
Origin: India, Chikmagalur region
Flavour and notes: caramel, nuts, orange, raisins, cocoa
Acidity: very low
Caffeine content: medium
Recommended for: espresso, milk based coffees
Brew in: automatic coffee machine, espresso machine, moka pot
Tech specs:
500 g / 1 lb
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Users reviews


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Philly VC Deals flat vs. last year; longer term funding may be concern
Tom Paine
Venture Capital investment in Philly Metro area companies was just under $120 million in the third quarter of 2011, according to the PricewaterhouseCoopers/National Venture Capital Association MoneyTree report based on data from Thomson Reuters, released Wednesday. This was more than the $89 million reported in Q2, but less than the $124 million reported in the same quarter last year. Total investment for the first three quarters of 2011 was $337 million, compared to $334 million for the first three quarters of last year. Thirty-six deals were reported in the quarter.
In terms of individual investments, there were no surprises; all the large deals had previously been announced. ISGN, the Bensalem-based mortgage processing technology business, was the largest recipient, raising $30 million. Boston-based OpenView Venture Partners' trio of area investments, Monetate, NextDocs, and Xtium, which I wrote about here, accounted for about $31 million (though I believe these numbers don't reflect another $5 million invested in Xtium).
Other IT-oriented investments included Instamed ($5.5 million), GreenPhire ($1.5 million), Lightning Gaming of Boothwyn ($1 million), Cross Current Corporation of Doylestown ($800,000), Vita Products of Philadelphia ($700,000), and Sanovia of Philadelphia ($500,000). PlaySay, which the report says raised $250,000, has since moved to Washington DC and now has raised a total of $550,000 from Bethesda, MD-based Novak Biddle Venture Partners. AssetVUE and MobileReactor LLC both recently raised $200,000 from Ben Franklin Technology Partners, as was announced ealier this week. Connectify raised an unspecified amount from an investment firm related to the US Intelligence comunity, and recently launched spare space rental site Storably is also reported to have raised funds.
Some angel investments and other larger private equity investments may not be included in the MoneyTree report.
Nationally, VC investment was up 31% over the prior year"s third quarter. Software investments reached $2 billion, the highest level in nearly a decade.
The biggest concern going forward is whether the current level of funding can be maintained. Venture Capital fundraising hit an eight year low in the third quarter, dropping 53% from the prior year, according to the National Venture Capital Association, and VC investments are far outpacing fundraising as many firms are working downs funds they had previously raised.