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In digital marketing, organic search is the heart of marketing because of its focus on and understanding of user intent, making an SEO specialist or expert a highly important marketing role. Search engine optimization experts are responsible for more than half the traffic on an average website, bringing in about 51% of all your site's visitors. Considering that sites which manage to secure the top five positions on the SERPs receive an estimated 67.6% of clicks, it is clear that earning a top rank can have a tremendous impact on your business growth and revenue.
Earning those SEO specialist and expert spots, however, generally requires a strong understanding of SEO, including how to do it, the latest best practices, and how to measure your results. The idea of becoming a SEO expert can seem overwhelming to many. The algorithm used to rank search results is regularly changing and the best practices are continually adapting to these adjustments. There are also a variety of conflicting opinions concerning the most effective SEO practices because no one actually knows the algorithm. Effectively doing SEO also requires practitioners to have a good idea about how to run metrics and analyze sites so they can see the results of their efforts. It is no wonder why many people unfamiliar with SEO feel intimidated by the prospect. For Digital Marketing Services Check Vivid Digital
It is possible, however, to begin the process of becoming a SEO expert from your desk chair. In fact, a few key steps can help you remain abreast of the latest developments and help you become a competent SEO marketer, benefiting both your organization and your professional aspirations.
Here are some tips to become an SEO Expert :
Now that you are convinced that improving your SEO skills is not only for SEO professionals, let's see what's the fastest way to become an SEO Expert yourself.
Tip 1:Understand how search engines work
Before even starting to think about SEO, the first step you need to take is to familiarize yourself with how search engines work.For many people this may be something that they already know (or think they know), but it's always good to start with the basic concepts and then work your way up to the most complicated theories.The resources below will help you understand how Google search engine works, which is similar to how other search engines work too.
Tip 2: Get to know The Basic Search Engine Marketing Concepts
Before getting your hands dirty, you should have a general idea about all the different disciplines that make up search engine marketing and digital marketing and not just SEO.You should have clear in your mind what to expect from SEO and what other tools you can use in conjunction with SEO to make your Internet presence stronger.
Tip 3: Understand the true meaning of SEO
SEO is not just about keywords and links, it's much more than that. The true mission of SEO is to provide users with a great experience and give them exactly what they want.Your goal is not just about getting more search engine traffic but it's about turning that traffic into recurring visitors and customers.
Tip 4: Choose the right SEO Training
Once you start learning SEO, you will realize one thing: There is too much information about SEO on the Internet and so many things to learn and this at the end creates a mess.If you decide to do this on your own without any help, you will end up with an endless list of articles to read and things to try out.
It took me years to learn SEO this way because back in 2000 when I started, there were no SEO training courses or guides you could read and ave all the information in one place.Nowadays things are different. People wanting to learn SEO fast can do so by following a reputable course without having to spend endless hours searching the Internet and reading article after article.
Resources you can use:
The Complete SEO Course –Our own SEO course has everything you need to know about SEO. It covers both basic and advanced SEO concepts. You can take the course online or download the material as PDF and learn at your own pace. It is the only SEO Course you'll ever need to read.
Google Digital Garage –Google has created a new set of courses covering everything you need to know about Digital marketing. They don't go into the fine details of SEO but they are a great resource if you want to familiarize yourself with online marketing.
Moz SEO Course –Moz is company famous for their tools but they also created an SEO course which covers the basics of SEO. It's not complete but it's a good start for beginners.
SEO Guide -This is another guide from Google. It covers SEO from Google's perspective. This means that you will not learn what actually works for SEO but what Google wants you to learn about SEO. Nevertheless, take a couple of hours and go through the guidelines, there are some good pieces of advice worth thinking about.
Tip 5: Stay informed about SEO changes
SEO is not a static discipline. SEO rules and algorithms change all the time. Google alone is making more than 250 changes to their ranking algorithms per year. Good SEO experts need to know about these changes and adjust their SEO campaigns accordingly.
The best way to stay informed is to follow a couple of SEO news websites that are proven to provide information about on-going SEO changes when they happen and not after it's too late to do something about it.
Resources you can use:
Search Engine Roundtable –A must follow website by all SEO experts. Daily news about everything that is happening in the SEO industry. For me this is the most valuable and useful SEO news website in our industry.
Search Engine Land –One of the oldest websites in the SEO industry. Previously owned by Danny Sullivan, now he works for Google.
Google Blog –Google recently established a blog for sharing news related to Google products. They occasionally share news about Google search as well.
Google search blog –a blog by Google dedicated on Search.
Google Webmasters Blog –the official Google webmasters blog. Follow to get news about the latest changes in search.
Reliablesoft SEO Blog –Our own SEO blog. It is updated on a weekly basis with guides, step-by-step articles and resources to help you practice SEO efficiently.
Tip 6: Choose the Right SEO Tools
The truth is you cannot do SEO alone. There is so much information to process and decisions to make and if you try to do everything manually, you will spend your precious time into analyzing numbers instead of working on tasks that can get you better results.
It's also true that good SEO tools cost but in the long term the return is much more than the monthly fee you will pay for a good SEO tool. SEO Agency in Hyderabad visit here
Tools you can use:
Google Webmaster Tools (Free) –Google webmaster tools is perhaps one of the most useful tools for SEO. It is free and it can give you a lot of information about your website. Read my previous guide on how to use Webmasters tools to improve your SEO.
Google Analytics (Free) –Another free tool by Google. You can use Google analytics to learn a lot of things about your traffic and how users navigate your website. There are a lot of reports to explore and many metrics to analyze. This article, Google analytics for beginners, is a great place to start.
SEMRUSH (Paid) –This is my favorite SEM tool. It's not free but you can use it for your SEO, PPC campaigns, competitor analysis, keyword research, link building, social media monitoring and many more. It is updated frequently with new features and it's one of the best investments you can make for your SEO.
Ahrefs (Paid) –An alternative to SEMRUSH. It comes with a monthly subscription but it's also one of the most respected SEO tools in the industry. Comes with a 7-day free trial so you can test it out before buying.
Tip 7: Practice SEO –Don't stay theoretical
SEO is not theoretical but it's mostly practical. The outcome from studying the SEO theory should be a list of actions you can apply to your website and improve your exposure in search engines.
The problem is that each website is unique and what works for one website may not be the best solution for others. That's why it is necessary to actually practice SEO and not just stay theoretical.Reading case studies on how others have managed to succeed with SEO campaigns it's a great way to get new ideas you can use and the inspiration you need to keep trying until you get SEO right.
Tip 8: Demonstrate your SEO Expertise
They say that one of the best ways to learn something is to try to explain it to other people. This is true with SEO as well.I have learnt a lot of things and improved my SEO skills considerably when I started writing about SEO.My recommendation is to start an SEO blog or a personal blog and share your SEO experiences with other people.Over time you will find that sharing knowledge is a great way to learn new things about SEO and at the same time you help other people, which is a highly rewarding experience.
Tip 9: Be Patient
There is no way to talk about SEO and not mention the word "patience". SEO takes time to work and you shouldn't rush into conclusions too soon.SEO is not the quickest way to increase your traffic. If you want immediate results then try PPC campaigns. SEO is about creating a long term sustainable business by building a solid foundation that will get you organic traffic 24/7 for years.
Before making any SEO related change to your website you should take note of your rankings and traffic (for a period of time), before the change and compare it with the same period of time (in terms of duration), after the change. Monitor your rankings and traffic and give it enough time before taking further decisions.
Tip 10: Follow the leads of established SEO Experts
Last but not least, in your path to become an SEO expert, you will face a number of difficulties. There will be times when you will be disappointed, frustrated and ready to give up.Don't worry, this is normal to happen. If you read the stories of other people you will understand that none of them became what they are today because they are lucky. It's the result of hard work and endless hours of testing and reading about SEO.
The list below includes 5 SEO experts you definitely need to follow for inspiration and for understanding how SEO can be applied in scale. All 5 have managed to build multi-million businesses and they managed to do it because they know how to use SEO correctly. Read their stories and spend some time analyzing their SEO practices. You may find that sometimes they do things differently than 'traditional' SEOs and this is because they have the confidence and expertise to try new things and experiment with SEO without being afraid to fail.
Neil Patel –One of the most respected SEO Experts in the industry. Don't just read his blog but try to analyze his practices and how he managed to use content SEO in scale.
Brain Dean –He is the expert in link building. His blog is a great resource for case studies and techniques you can use to get fast results.
Eric Enge –Speaker, Founder and CEO of Stone Temple. An SEO with years of experience in the industry.
Joost de Valk –Founder and CEO of Yoast, the most popular SEO plugin.
Rand Fishkin –Co-Founder of MOZ, great presenter and entrepreneur.
Everyone that has anything to do with a website or online business should become an SEO expert.The list includes marketing managers, developers, webmasters, web designers, social media managers, PPC experts, solo entrepreneurs and ecommerce owners.Why? Because SEO is at the base of all digital marketing campaigns. SEO principles will not only guarantee the maximum possible exposure in search engines but they can help a website in more ways.
Becoming an SEO Expert is not easy but it's not difficult either. The process includes a lot of reading, practicing and testing.If you are starting out now, the best way is to take a good SEO course so that you have all information in one place, use the right SEO tools and above all start practicing SEO. Learn from your mistakes and try again.Search engines and SEO are here to stay for years to come and this is the best investment you can make for your business and personal skills.


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If you're like me, you might have a dream that surfers will soon not have to rely on plug-ins to enjoy browsing the web. For fellow dreamers, the forthcoming and latest round of browser wars might lead to a better web experience rather than yet another plug-in based nightmare.
Microsoft has recently had to grin and bear the pain, while its dominant Explorer browser has seen its market share attacked by a series of platforms, including Mozilla Firefox, Apple Safari – and most notably – Google Chrome. With market share now hovering at round 60% (see further reading, below), it's almost as if the top guys at Redmond have suggested that enough is enough.
The result is a return of the browser wars, with Microsoft set to preview the final beta of Internet Explorer 9 (IE9) in September. Chrome is clean, simple and fast – and expectations will be that IE9 provides a much quicker browsing experience.
Initial signs look good. Graphics performance is enhanced and hardware is accelerated. But the real story is the heavy use of HTML5, showing that researchers in Redmond also feel the next generation mark-up language is the best way forward for development.
"The future of the web is HTML5," suggested Dean Hachamovitch, the general manager for Internet Explorer in a blog post earlier this year (see further reading). With Apple and Google also throwing their weight behind HTML5, much debate has rightly centred on the tricky situation facing Adobe's video plug-in Flash.
But Microsoft's support for HTML5 potentially creates another set of circumstances and another high profile conflict. This conflict surrounds Silverlight, a web framework that integrates multimedia and graphical elements in a single environment.
More intriguingly, it is Microsoft's own framework – and, since April 2007, it has formed the backbone of the provider's presentation framework. So, where does Microsoft's support for HTML5 leave Silverlight? That, for web developers, is the key question.
Online publication The Register recently referred to the clash as "The Silverlight Paradox", suggesting that a high quality and HTML5-ready IE9 will surely make many of the features of Silverlight and Flash redundant (see further reading).
Such a paradox, however, is fraught with complications. IE9 might look like it provides new fuel for Microsoft's browser battle, but the true level of optimisation will not be clear until web developers get their hands on beta.
As The Register article suggests, legacy requirements mean the use of plug-ins will persist for many years – even if IE9 delivers everything it promises. But the move towards HTML5 shows that the captive strength of plug-ins is waning and businesses must develop web platforms with capability across all levels, from the desktop through to the mobile. The new web experience is emerging.
Further reading:
Tags: css3, Customer experience, Graphical User Interface, GUI, HTML5, Layered Architecture, mobile, mobile applications, mobile development, mobile internet browsers, Modern web, Multiple Access Devices, Presentation layer, RIA, Rich Internet Applications, Rich Web application, UXP, Web 2.0, Web design

subset: commoncrawl


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Get your dream home built by getting in touch with Alkel Homes Ltd for high quality building services. We offer exceptional new builds and home improvement services at really affordable prices. Get in touch with our team of professionals to discuss your needs and requirements. We have several years of experience in the home construction trade. We are proudly associated with NHBC. As NHBC registered builders we can provide 10 year NHBC warranties for your peace of mind on any new properties built.
Hives Removal
We specialise in construction drawings, designs and planning applications. Do not hesitate to share your ideas with us. We always endeavour to exceed your expectations.
• New builds
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Our team of skilled workmen are experienced and qualified to undertake all types of projects.
You can also contact Alkel Homes Ltd for extensions and other home refurbishment services. Do have a look at our previous projects. We have been proudly serving Swansea and surrounding areas.
Call us for a FREE estimate today


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Welcome to The Balnoon Inn
The Balnoon Inn is a pub with a restaurant and rooms located in the hamlet of Lelant Downs, next to St Ives, Cornwall in a recognised area of outstanding natural beauty.
A quintessential English Inn, in a gloriously rural setting, situated between Trink and Trencom hills.
Balnoon was a small tin mining village, and we still have within our grounds the ruins of a chapel built for the miners and their families.
The aim is to make the Inn full of character, a great individual place to eat, drink & sleep; a place for local people, businesses, families & tourists to meet and call their own.


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NOBLE COUNTY, Ind. (WFFT) - A motorcycle driver was flown to the hospital after leading police on a chase in two counties Saturday.
Just before 5 p.m., the motorcycle driver was leading DeKalb County Sheriff Deputies on a chase on CR 52, which turned into CR 100S in Noble County.
The Noble County Sheriff's Department said the driver lost control as he crossed the crest of the road and tried to go through a small curve at CR 1200E.
Deputies said the driver braked hard, left the road and was ejected, landing in a water filled drainage ditch along CR 100 S.
The driver was flown to a Fort Wayne hospital because of the severity of his injuries.
The Noble County Sheriff's Department said the driver driver was operating a vehicle while suspended (prior) with a total of 82 current points on his operator's license.


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JAKARTA (RambuEnergy.com) – State-controlled coal producer PT Bukit Asam Tbk (IDX:PTBA) opens a tender for Overburden Removal works as well as heavy equipment and dump trucks rental for coal getting.
The bid winner will carry out overburden removal at a volume of 19 million BCM per annum within the period of 2019-2023 (60 months) at the company's mining site in Tanjung Enim, South Sumatera.
The second work will encompass overburden removal for 58 million BCM per year for the period of 2019-2023 or 60 months.
The registration date is set before Nov. 28, 2017 through the website: www.eproc.ptba.co.id.
Bukit Asam aims to increase its coal production to over 30 million tons per annum from around 23 million tons per annum at present, in line with the enlarged capacity of its railways to transport coals to the nearby coal ports.


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Parts 1, 2, 3 and 4 of this story about an empty grave found in an under-construction Beltline where we try to ascertain whether I can write a compelling story with hip-hop as the background. We just found out the kid with a "gang tag" doing his homework in the car the night of the pot festival is an aspiring rapper with a hip-hop pedigree that connects him to Big Daddy Jay, who a decade ago was a big star, but is now a producer, and recently out of jail in New York where he took the fall for a protégé:
Richard Evans looked nothing like an English teacher. He was built like a college running back and dressed like an upscale homeless man, in old army pants and a T-shirt from a 1998 charity walkathon, stretched tight over his chest. "All week, I have to wear dress shirts and slacks; you get me here on the weekend, you get me in rags." From where he stood atop a chair, he gestured to Diana for the stapler: with this, he attached the rest of a decorative border around a bulletin board full of different examples of poetic forms. "So what is it y'all are looking for?" He was all smiles, eyes flashing, clearly fancying Diana.
"Well, Mr. Evans, we have one question, but maybe you can help us with two." He wasn't her type, Mustapha thought—too beefy and too short—but he could tell she enjoyed the attention. She showed him the photo of Christopher. "Tell us about this kid."
Evans' face fell. "Oh, man." He hopped down from the chair. "Tell me he hasn't done something stupid."
"Nothing truly felonious. Maybe at worst, a lookout, or driver. Why does he go to school here? His grandma said magnet school?"
"Sure. Tri-Cities is a magnet for the performing arts. I'll bet even you have heard of OutKast? They went here, back in the day. So every wannabe rapper from all across Atlanta figures they can replicate that. My job is to teach them there's more about poetry than just rhyme. Christopher? He actually listens."
"So he's got a future as a rapper?"
"Maybe. Good flow, decent diction, and a pedigree. His family were all real gangsters, which is the problem. They were hard and he isn't. Which is a point in his favor as a human being, but not so much as a rapper. He tells good stories, and he's heard good stories; but he hasn't got the skill to front himself. And in modern hip-hop, goofball kids with a fine sense of observational humor, like OutKast, aren't going to make it. It's a real shame. In a perfect world? We airlift him out of that ghetto, send him to college, have him write a newspaper column or a blog or something. He could do standup comedy. But make it big in modern hip-hop? Not so much."
"Okay. Tell us about Big Daddy Jay."
"He's in town. Heck, my students are over in Pittsburgh watching him right now. And he and Christopher are related. Not biologically; more like a hip-hop genealogy."
"Pretend we're tourists from another planet. Go back to when Big Daddy Jay was getting his start."
"Sure. You want, I can use your iPad and bookmark sites for you." Evans led them to his desk, pulled out student desk chairs for both of them. "Okay. Back in 1998, Big Daddy Jay moves to Pittsburgh from middle-class suburbia, hooks up with the Pirate Mafia, who were a real gang. Pittsburgh Pirates, like the baseball team, right? Jay had flow, and business skills, but zero street cred. He gets together with this guy, Sweet T, who could write, and Thirty Ought, who had a shit-ton of street cred but couldn't rap or write. Which is strange, because it's Thirty Ought who had the musical pedigree. You see, back when, his own daddy was big in the electro-funk scene, early '80s arpeggiated stuff. Nothing you've probably heard of, but they put out a bunch of club hits under the name Electrifyin' Warpdrive. That money is what funded the New Pirate Mafia. Big Daddy Jay did the business end, Sweet T wrote and performed, Thirty Ought looked good in videos and cover art, also provided the seed money. Here, this is Thirty Ought from about 2001."
Evans called up a photo of what to Diana was a living stereotype: bandanna, wife-beater, tattoos, bullet scars, grim attitude. "Keeping it real," she said.
"That was his function. Thing is, he was real. Thirty Ought and Sweet T were no-foolin' real gangsters. Christopher's daddy and uncle were in the game with them. Between the two of them, Sweet T, and Thirty Ought, they probably put a dozen other players in the ground before the New Pirate Mafia got off the ground."
Mustapha said, "So what happened to the band? Where are the other two guys?"
"Well, Sweet T's dead. Back in… 2005 or so? Smoking weed in the tub, kicking it old school listening to a boombox. It fell in the tub, power was on, that's all she wrote. Then there was a drive-by, and Christopher's daddy was killed and his uncle Keith went off to jail. Y'all's own gang unit took down what was left. Next thing, Daddy Jay is up in New York City managing other acts."
Diana said, "What did he do time for, up there?"
"Took a fall for someone else. He's got this protégé, Shawty G? Now there's a real gangster. They were clubbing, someone disses them, Shawty pulls a gun, security jumps in. Shawty has a record a mile long; a weapons charge is going to send him to Attica for life. Daddy Jay has a clean record—remember, he's from Stone Mountain, not Pittsburgh—and he claims the gun as his. Everyone knows it's bullshit, but he goes ahead and pleads guilty."
Mustapha said, "Protecting his investment."
Diana said, "Giving himself the real street cred he always lacked."
Evans said, "Y'all just went to the top of the class. Not only that, but when he was in jail, Jay met another aspiring rapper, got him a contract. Actually recorded a couple of cuts from his cell. He's due to get out soon, and he's got Big Daddy's marketing machine waiting for him."
Diana asked, "What happened to Thirty Ought?"
"He ran. Got tipped off the cops were coming for them, disappeared. Daddy Jay got a big hit off it: Miss You My Brother. He's like a ghost, now: every so often, you'll hear someone say they saw him at a show or a party."
"Hologram Tupac," said Mustapha.
"Yeah, sort of. Only we know Tupac is dead for real."
So here's where the story actually gets in to hip-hop. It's easier to do because it's at two removes: Mr. Evans is telling the story, and it all happened ten years ago. I can create a rap group without having to actually have them right there, or give you any of their rhymes: this way, the characters can sneak up on you smoothly enough without truly alerting you to my lack of acquaintance with 20-teens hip-hop.


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Stress And Anxiety Dimensions On Developmental Coordination DisorderPor: A. M. Pellegrini, C. Y. Hiraga, D. T. Gama, M. C. Ferracioli e P. P. Marola.
IX Congresso Internacional de Educação Física e Motricidade Humana XV Simpósio Paulista de Educação Física
Recent studies suggest that children with Developmental Coordination Disorder (DCD) are at risk of internalize psychosocial difficulties as low self-esteem, stress, anxiety and depression influencing negatively on their everyday activities. Consequently, DCD children reject to participate in free and organized physical activities with impact on their full development. The Child Psychology area of study considers the nature of stress and anxiety reactions in four different dimensions: physical, psychological without and with depressive components and psychophysiological. Although stress and anxiety have been identified in DCD children, the literature do not explore the nature of the dimensions of these reactions. The aim of the present study was to compare these stress and anxiety dimensions of DCD children with those of typical development children (TD). Seventy-two children 8 to 12 years old participated in this study. Following the American Psychiatric Association (APA-DSM V) criteria for DCD, two groups of children were composed: 22 DCD children (mean age 10.6 years old) and 51 TD children (mean age 10.5 years old). All children answered the Child Stress Scale (SSC), a questionnaire validated for Brazilian children from 6 to 14 years of age aiming to ascertain the stress and anxiety reaction dimensions. A Psychologist applied the SSC questionnaire for groups of eight children in a quiet private classroom in their own school. Mann-Whitney U test was applied in the results of each reaction dimension of the SSC questionnaire, with p <0,05 for significant differences. The results indicated that DCD children showed more stress and anxiety reactions than TD children on the physical, Z(72) = 2.87 p < 0,01, psychological with depressive components, Z(72) = 2.20 p < 0.05, and psychophysiological, Z(72) = 2.32 p < 0,05 dimensions. No significant differences were found in the reactions of the psychological dimension, Z(72) = 1.77 p = 0,07. The present study indicated that physical, psychological with depressive components and psychophysiological reactions are the most relevant dimensions for stress and anxiety of DCD children. It is also important to discuss that the child stress, anxiety emerge from different dimensions of reactions, and that assessment and analysis of the reaction dimensions are important for identification of the relative consequences of motor difficulties on the DCD children daily activities. Physical therapists worried with stress and anxiety problems should be aware of the results of this study to provide effective treatment and intervention programs.
Endereço: http://www.periodicos.rc.biblioteca.unesp.br/index.php/motriz/article/view/10060/10060
Tags: Ansiedade, Coordenação, Desenvolvimento, Estresse


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Oct 04, 2018 Press Release for Alnylam
Alnylam Reports Updated Positive Results from Phase 1/2 Study of Lumasiran in Patients with Primary Hyperoxaluria Type 1
Oct 04, 2018
− Lumasiran Treatment Resulted in 75 Percent Mean Maximal Reduction
in Urinary Oxalate Relative to Baseline, with 100 Percent of Patients
Achieving Levels of Urinary Oxalate Less Than 1.5
− Lumasiran Shows Encouraging Safety Profile with a Median of Seven Months and up to 14 Months Study Duration –
− Company Initiates ILLUMINATE-A Phase 3 Study –
results from the Phase 1/2 study were as of a data cut-off date of
"We are pleased to present these data that we believe provide a strong foundation for lumasiran as an investigational RNAi therapeutic for the treatment of PH1, a devastating and life-threatening disease caused by overproduction of oxalate that deposits in the kidneys and other tissues. We're also excited to have now initiated the ILLUMINATE-A Phase 3 pivotal study, which is expected to read out in late 2019, supporting a potential regulatory approval in 2020, if positive," said Pritesh J. Gandhi, PharmD., Vice President and General Manager, Lumasiran program at Alnylam. "Given the lack of approved treatment options, we believe lumasiran has the potential to address the significant unmet need that PH1 represents."
"PH1 is an ultra-rare disease characterized by an inevitable and
progressive decline in kidney function leading to systemic
manifestations and ultimately multi-organ dysfunction. Once the kidneys
fail, the only viable therapeutic option is a dual liver/kidney
transplant," said Prof.
The Phase 1/2 safety results in patients with PH1 were based on a median study duration of seven months (range: 5 to 14 months) since first dose. As of the data cut-off date, there were no discontinuations from study treatment. Serious adverse events (SAEs) were reported for one patient (33 percent) receiving placebo and five patients (25 percent) receiving lumasiran; none were related to study drug. The placebo patient experienced acute pyelonephritis and kidney stones. The lumasiran patients with SAEs included one patient with vomiting, one patient with abdominal pain, fever and vomiting, one patient with gastroenteritis, and two patients with kidney stones. Adverse events (AEs) were reported in three (100 percent) patients during placebo dosing and 19 (95 percent) patients after lumasiran dosing. The majority of AEs were mild or moderate in severity and were assessed as unrelated to study drug. Injection site reactions (ISRs) were reported in three (15 percent) patients receiving lumasiran. ISRs were mild or moderate in severity and were self-limiting. Lumasiran was not associated with any clinically significant adverse laboratory findings. In patients receiving lumasiran, plasma glycolate levels increased consistent with the pharmacology of lumasiran and results from healthy volunteers in Part A of the Phase 1/2 study. This increase was not associated with any safety findings.
About the Lumasiran Phase 1/2 Study Part B
The Phase 1/2 Part B study of lumasiran is a randomized (3:1 drug:placebo), single-blind, placebo-controlled evaluation of lumasiran in patients with PH1. In this multi-dose study, patients in Cohorts 1 and 2 received three monthly doses of lumasiran at 1 mg/kg or 3 mg/kg, respectively; Cohort 3 received two quarterly doses at 3 mg/kg. An additional eight patients received open-label lumasiran in expansions of each of the first two cohorts, totaling 20 patients enrolled. Patients randomized to the placebo group also received subsequent subcutaneous administration of lumasiran following administration of placebo. Patients had a mean age of 14.9 years (range: 6-43) and a mean estimated glomerular filtration rate (eGFR) of 77 mL/min/1.73m2 (range: 42-131).
About the ILLUMINATE-A Phase 3 Study
The ILLUMINATE-A Phase 3 trial is a randomized, double-blind, placebo-controlled, global, multicenter study to evaluate the efficacy and safety of lumasiran in approximately 30 patients with a documented diagnosis of PH1. Patients will be randomized 2:1 to receive three monthly loading doses of lumasiran or placebo at 3 mg/kg followed by quarterly maintenance doses. The primary endpoint is the reduction of urinary oxalate at six months relative to baseline in the patients treated with lumasiran as compared to placebo. Key secondary and exploratory endpoints will evaluate additional measures of urinary oxalate, estimated glomerular filtration rate (eGFR), safety and tolerability, and quality of life. At month 6, the placebo patients will cross over to the lumasiran arm for long-term follow up out to 60 months. For more information on ILLUMINATE-A (NCT03681184) please visit clinicaltrials.gov, email email@example.com or call 877-256-9526 in
About Lumasiran
Lumasiran (formerly known as ALN-GO1) is an investigational RNAi therapeutic targeting glycolate oxidase (GO) in development for the treatment of Primary Hyperoxaluria Type 1 (PH1). Lumasiran is designed to reduce hepatic levels of the GO enzyme, thereby depleting the substrate necessary for the production of oxalate – the metabolite that directly contributes to the pathophysiology of PH1. Lumasiran utilizes Alnylam's Enhanced Stabilization Chemistry (ESC)-GalNAc-conjugate technology, which enables subcutaneous dosing with increased potency and durability and a wide therapeutic index. Lumasiran has received both U.S. and EU Orphan Drug Designations, a Breakthrough Therapy Designation from the U.S. Food and Drug Administration (
About Primary Hyperoxaluria Type 1 (PH1)
PH1 is an ultra-orphan disease in which excessive oxalate production results in the deposition of calcium oxalate crystals in the kidneys and urinary tract and can lead to the formation of painful and recurrent kidney stones and nephrocalcinosis. Renal damage is caused by a combination of tubular toxicity from oxalate, calcium oxalate deposition in the kidneys, and urinary obstruction by calcium oxalate stones. Compromised kidney function exacerbates the disease as the excess oxalate can no longer be effectively excreted, resulting in subsequent accumulation and crystallization in bones, eyes, skin, and heart, leading to severe illness and death. Current treatment options are very limited and include frequent renal dialysis or combined organ transplantation of liver and kidney, a procedure with high morbidity that is limited due to organ availability. Although a small minority of patients respond to Vitamin B6 therapy, there are no approved pharmaceutical therapies for PH1.
About RNAi
RNAi (RNA interference) is a natural cellular process of gene silencing that represents one of the most promising and rapidly advancing frontiers in biology and drug development today. Its discovery has been heralded as "a major scientific breakthrough that happens once every decade or so," and was recognized with the award of the 2006 Nobel Prize for Physiology or Medicine. By harnessing the natural biological process of RNAi occurring in our cells, a new class of medicines, known as RNAi therapeutics, is now a reality. Small interfering RNA (siRNA), the molecules that mediate RNAi and comprise Alnylam's RNAi therapeutic platform, function upstream of today's medicines by potently silencing messenger RNA (mRNA) – the genetic precursors – that encode for disease-causing proteins, thus preventing them from being made. This is a revolutionary approach with the potential to transform the care of patients with genetic and other diseases.
Alnylam (Nasdaq: ALNY) is leading the translation of RNA interference (RNAi) into a whole new class of innovative medicines with the potential to transform the lives of people afflicted with rare genetic, cardio-metabolic, hepatic infectious, and central nervous system (CNS) diseases. Based on Nobel Prize-winning science, RNAi therapeutics represent a powerful, clinically validated approach for the treatment of a wide range of severe and debilitating diseases. Founded in 2002, Alnylam is delivering on a bold vision to turn scientific possibility into reality, with a robust discovery platform. Alnylam's first U.S.
Alnylam Forward Looking Statements
Various statements in this release concerning Alnylam's future expectations, plans and prospects, including, without limitation, Alnylam's views with respect to potential for lumasiran to address the significant unmet need that PH1 represents, the initiation of the ILLUMINATE-A Phase 3 study and the expected plans and timing to report topline results from ILLUMINATE-A and, if positive, submit filings for regulatory approval, and expectations regarding "Alnylam 2020" guidance for the advancement and commercialization of RNAi therapeutics, constitute forward-looking statements for the purposes of the safe harbor provisions under The Private Securities Litigation Reform Act of 1995. Actual results and future plans may differ materially from those indicated by these forward-looking statements as a result of various important risks, uncertainties and other factors, including, without limitation, Alnylam's ability to discover and develop novel drug candidates and delivery approaches, successfully demonstrate the efficacy and safety of its product candidates, the pre-clinical and clinical results for its product candidates, which may not be replicated or continue to occur in other subjects or in additional studies or otherwise support further development of product candidates for a specified indication or at all, actions or advice of regulatory agencies, which may affect the design, initiation, timing, continuation and/or progress of clinical trials or result in the need for additional pre-clinical and/or clinical testing, delays, interruptions or failures in the manufacture and supply of its product candidates, obtaining, maintaining and protecting intellectual property, Alnylam's ability to enforce its intellectual property rights against third parties and defend its patent portfolio against challenges from third parties, obtaining and maintaining regulatory approval, pricing and reimbursement for products, progress in establishing a commercial and ex-United States infrastructure, successfully launching, marketing and selling its approved products globally, Alnylam's ability to successfully expand the indication for ONPATTRO in the future, competition from others using technology similar to Alnylam's and others developing products for similar uses, Alnylam's ability to manage its growth and operating expenses, obtain additional funding to support its business activities, and establish and maintain strategic business alliances and new business initiatives, Alnylam's dependence on third parties for development, manufacture and distribution of products, the outcome of litigation, the risk of government investigations, and unexpected expenditures, as well as those risks more fully discussed in the "Risk Factors" filed with Alnylam's most recent Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission (
Lumasiran has not been approved by the FDA, EMA, or any other regulatory authority and no conclusions can or should be drawn regarding the safety or effectiveness of this investigational therapeutic.
View source version on businesswire.com: https://www.businesswire.com/news/home/20181004005071/en/
Alnylam Pharmaceuticals, Inc.
Christine Regan Lindenboom, 617-682-4340
(Investors and Media)
Josh Brodsky, 617-551-8276
For Media Inquiries, please contact:
Christine Lindenboom
SVP, Investor Relations & Corporate Communications email@example.com 617-682-4340
For Investor Inquiries, please contact:
Josh Brodsky
Director, Investor Relations & Corporate Communications email@example.com 617-551-8276
Essential assets and documents related to Alnylam


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We weren't going to publicise this app that Tquila Labs has been building, but Salesforce has just blogged about a simplified version of what we're calling Project FormStorm. After some thought we decided we'd put the beta video up for y'all to see. In a nutshell, FormStorm delivers the following:
- OAuth against your Salesforce Org so no need for a separate account
- Creation of forms in a WYSIWYG drag-n-drop editor
- Linking the forms and the fields to ANY object and fields in your Salesforce Org
- Publishing the form as a Heroku application with it's own public URL and publishing to Facebook!
Of course a video is a thousand pictures which are each a thousand words, so here's 1 000 000 words:
If you'd like to know more please drop me an email on firstname.lastname@example.com.


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Butterscotch Brownies
Substitute pecans for the walnuts or add chocolate chips in place of the white chips. For extra crunch forget the chocolate and add extra chopped nuts.
The result is chewy and crunchy with a hint of caramel. Delicious.
Butterscotch Brownies
1/4 cup butter
1 cup brown sugar
1 egg
1/2 cup flour
1 teaspoon baking powder
1/2 teaspoon salt
1/2 teaspoon vanilla
1/2 cup white chips (Ghiradelli)
1/4 cup chopped walnuts
Melt butter in a pan over low heat. Add the brown sugar and stir until the sugar just begins to melt. Remove from heat and cool.
In a bowl whisk together flour, baking powder and salt.
Add 1 egg and vanilla to the cooled butter, brown sugar mix. Stir in the flour mixture. Add the walnuts and the white chips.
Spread dough into a 9x9 inch pan.
Bake 350 degrees for 20-25 minutes or until golden brown. Cool before cutting into 12 pieces.


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A unique opportunity to own a 3 bed 2 bath log cabin in the heart of Carmel. The moment you step foot on this beautiful property you will feel transformed. The rustic country setting is peaceful yet in the middle of all that Carmel has to offer. The wrap around porch is a great vantage point to enjoy the grounds. When you step inside you are greeted by a large great room with a cozy feel. The kitchen is large offering great prep space and loads of cabinet space. There is one bedroom on the main level and another room that could make a great office or hobby space. The upstairs offers spacious bedrooms and a quaint loft space. Two large garages offer great storage. All of this situated on a picturesque lot.
Listing courtesy of Jeff Paxson Real Estate Browns. Selling Office: Jeff Paxson Real Estate Browns.
Information Deemed Reliable But Not Guaranteed. © 2020 Metropolitan Indianapolis Board of REALTORS®


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SDSL pt1: Colectivismo (3 de 3)
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These symbols and the knowledge they contain exist within our psyches from the moment we come into the world. They are called: "Archetypes" If you have ever taken anthropology you know that it's a kind of an occupational pleasure of anthropologists to show how exotic other cultures can be in that there are places out there where supposedly everything is the opposite to the way it is here. But if you, instead, look at what is common to the world's cultures you find that there is an enormously rich set of behaviors and emotions and ways of construing the world that can be found in all of the world's 6000 or like cultures. Well, first it's among the Navajo Indians healing ceremonies were conducted by way of sand paintings which are mostly mandalas on the ground and this idea of sand painting with mandalas appears also in Tibet. Now what do we make of that. That in two very different cultures the same imagery emerges. Yes, well there are only two ways to explain it and one is by diffusion. That an influence came from there to here. And the other is by separate development. And when you have the idea of separate development this speaks for certain powers in the psyche which are common to all mankind. Otherwise you couldn't have, and to the detail the correspondences Timber identified that is astonishing when one studies these things in detail. The degree to which the agreements go between totally separated cultures. That was Carl Jung's idea which he calls the Archetypes of the Collective Unconscious. What do you mean by Archetypes? An Archetype is a constant form a basic fundamental form which appears in the works of that person over there and this person over here without connection. And they are expressions of the structure of the human psyche. Archetypes are as yet undefined structures of knowledge, intrinsic to the human psyche, often termed as Complexes Normal complexes develop through experiences, nurturing or debilitating which form connecting strands of information that are unconsciously linked. Archetypes however, are not formed through experience. As a person grows the unconscious mind begins to apply symbols to the Archetypes in order to better communicate the information existing in them to the conscious mind. Since these symbols are common to all cultures and peoples regardless of environmental circumstances Jung's discovery led him to conclude that this inborn information was not coincidental, but universal. Humanity was tied together by an unseen but intuitively felt network. He also found that only through individuation the process of awareness and coming to terms with the one's own unconscious could a person understand this collective unconscious. Ironically, only by being psychologically and spiritually free from the collective, could one come to understand and appreciate his connection with the greater whole. In ancient alchemy this was called microcosm and macrocosm. The whole within the whole. This concept has found a place in almost every religion on earth. But it's meaning is often suppressed by collectivists who recognize it as a threat to the centralization of power. Jung's archetypes are tangible proof that humanity is linked together in a great chain by something we do not fully understand. Something timeless and universal which binds the hearts of men together. The emotional need to understand the collective unconscious is what draws us towards collectivism. Far more even than the need for survival. Collectivists attempt to distract people away from this very real and preexisting connection. Causing them to feel isolated and out of balance. They then replace the missing connection with a fabrication of their own design. Often a social power structure views dominate the masses. However, only individuation can allow mankind to truly understand its ties to others and the world around him. Therefore only a society or collective that promotes man's innate psychological and spiritual individuality can succeed and support humanity indefinitely. A collective of individuals. Throughout history there have only been a few barely realized collectives of individuals. All have been violently wiped out by men who desired a different kind of collective in which individuality is reserved for the few. The many are wrapped in the bondage of the blank slate mentality. Slaves to their environments and the one. The source of all wisdom and freedom no longer exists. Sons of Darkness Sons of Darkness Sons of Light a Neithercorp original series Created by Brandon Smith and Josh Ogden The ideology that will construct our new world that you see is an ideology based on a resource management as denoted to the scientific method. Unification and pacification of the nations and people of the earth. Exactly you're saying that has nothing to do with it. It's imprinting We need a world peace as told by a world government. The leaders of the nations, with the consent of the people, should gather together to abolish war & establish world unity. There are no actual human instincts and I have tons of science to back this up. An education should be universal. You can fall sure. John, this is happening everywhere in the world We will fight to regain our freedom for everything is lost. Everything is fine. Everything is fine. Everything is fine. Everything is fine. Everything is fine. When anybody preaches disunity Tries to peep one of us against the other you know that person seeks to rob us of our freedom and destroy our very lives. And we know what to do about it. Now just wait a minute. No warrants please. That is the secret of American prosperity. The end Neithercorp.us
Video Details
Duration: 8 minutes and 56 seconds
Country: Argentina
Language: English
Genre: None
Views: 80
Posted by: xelnagah on Dec 28, 2010
Colectivismo (3 de 3)
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Sign In/Register for Dotsub above to caption this video.


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The Goodfight, a band from Atlanta, GA, announced that they would give away 100% of the revenue generated by their new record "Good & Evil" towards providing people with access to clean water through the work of "charity: water". Charity:water is involved in building wells and training nationals to maintain those wells on 5 continents, in some of the most desperate places on earth. Find out how they are fixing the problem at charitywater.
Tag Archives: Philanthropy
Beads of Courage
Created and operated by fellow artists, and making a difference in the lives of critically ill children, is Beads of Courage:
June 2, 2010: You can vote for "Beads of Courage" to receive $25,00 grant from the Pepsi Refresh Project by going here. A breakdown of how the funds would be used is included on this page.
Kiva – Microfinance
Give a Day – Jane Philpott
On her web site "Give a Day", Canadian physician Jane Philpott answers a common question:
Q: Isn't the situation of AIDS in Africa rather hopeless? What difference can we really hope to make?
Dr. Philpott's Answer: There is a West African proverb which says: "The river may be wide, but it can be crossed." There have been many situations in history when one might be tempted to despair that things would ever change. But in recent years we have witnessed the end of apartheid government in South Africa; the collapse of the Berlin wall; and peace accords in other long-standing conflicts. Yes, the crisis of AIDS in Africa is an exceptional one. Thus the response all over the world must also be exceptional. You can be a part of this worldwide response. Make a difference in your world. Give a day!
Please visit this dedicated woman's site to learn more about her creative and progressive ideas. Listen to an interview of Dr. Philpott by Shelagh Rogers on CBC's Sounds Like Canada.
Nick Anderson & Ana Slavin
Tired of waiting for others to change the world, these students did something about it:
Students should visit the Dollars for Darfur web site to learn more about how they can get involved.
Paying it forward
There are so many ways that each of us can help make the lives of others better, or happier. The "Pay it Forward Challenge" asks each of us to raise our awareness of others, and do something to spread kindness. Many people have come up with creative ideas in response…there are too many to list here, so just click on the link to watch and read about them! At this URL, you'll find ideas on how you can make a difference to the lives of others. (sorry, the links have been removed by the site)
Dr.Chandrasekhar Sankurathri: Beauty out of tragedy and loss
Dr. Chandrasekhar Sankurathri, otherwise known as "Dr. Chandra", lost his wife and two children in the tragic bombing of Air India Flight 182 from Canada to London in 1985. After three years of working through unbearable grief while employed as a government scientist in Ottawa, Dr. Chandra decided that he needed to "do something useful."
Inspired by his late wife's concern for the poor in her native India, Dr. Chandra opened the Sarada School — named for his daughter — in wife's home state of Andhra Pradesh.
After school is over for the day, the school bus is busily picking up blind and nearly-blind patients awaiting free cataract surgery at the Srikiran Institute of Ophthalmology, named for Dr. Chandra's son. India has about a quarter of the world's blind! Staff of the hospital is local, and receives a small salary and room and board. Five opthamologists are paid $1,500 per month; each surgeon performs approximately 150 surgeries per day.


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TRADE unions will today be warned they risk letting the Conservatives back into power if they keep up their criticism of the Government.
Wales Office minister Don Touhig will tell the unions that the Government has a "stark choice" between having the power to bring about change and "shouting helplessly from the sidelines".
The Government is facing mounting union hostility over public sector reforms.
The four biggest unions have struck a pact to co-ordinate voting at Labour's party conference to defeat the leadership on key policy issues.
It is the latest in a series of union attacks on the Government with the self-styled "awkward squad" leaders taking an increasingly hard-line attitude.
Union leaders are also planning a "reclaim the party" meeting at the conference. Union leaders will hold a rally under the banner "Putting Labour Back Into The Party".
In a speech to a rally in Cardiff Mr Touhig will round on those in the Labour movement who are "queuing up to condemn and denounce Labour in government".
"There is nothing wrong with critical debate. But there are some in our movement who Nye Bevan would say are afraid of the compromise of power," he will say.
"Those who think they will taste some sort of triumph to get some anti-Government resolution through this year's party conference may find all they are left with is a bitter taste."
He will warn of the stark choice facing them - "to have power to effect change, deliver social justice and increase opportunity for the many and not just the few or to shout helplessly from the sidelines.
"Let no one forget those 18 years of opposition. Do we want the Tories back?"
Mr Touhig will make the comments at a rally to commemorate Dic Penderyn, the folk hero sentenced to death for his part in the Merthyr Riots of 1831.
Mr Touhig will tell the Cardiff meeting the principles that inspired the Merthyr rioters are still alive in the modern Labour movement.
"There could be no greater tribute to Dic Penderyn than this Labour movement, more than a century and a half later, achieving the fairer and more just society he fought and died for."


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'Ferguson wouldn't say how many tries it took for him to knock the can down. "Just a few," he said, laughing.'
Archives for July 10, 2018
Post Time: This Shady McCoy flaunts his speed on track
'The 5-year-old trotter is named after the Bills All-Pro running back, dating to his time with the Eagles.'
Buffalo Bills training camp 2018: Breaking down 10 position battles
'Pitts joined the Bills last season in late-October while Buffalo signed Borders in December. Wallace and Carter were both undrafted free agent additions this offseason. Considering that none of the four have extensive playing experience, this competition should be considered wide open.'
Buffalo Bills Madden 19 ratings revealed | Micah Hyde No. 1
'However, Mike Straw of Sports Gamers Online received some of the Madden ratings early. Here's a look at Straw's list of Buffalo Bills players. When EA Sports reveals all Madden 19 ratings, this list will be updated.'
Bills rookie QB Allen not feeling pressure
'"Josh has a strong arm," head coach Sean McDermott said, per the team's website. "I think we all know that. I've been around the league long enough to know that it's one of the stronger arms. I'm not going to compare it to some of the guys I've been around. He's got a talented arm, so within that, there's other areas that are just as important, though, for arm strength, and that's where we have a lot of work to do. The great part about Josh is [that] he came in with a great mindset. He's embraced that growth mindset of getting better every day and that's what we're looking forward to in the future."'
Josh Allen: 'There really is no pressure' heading into rookie season with the Bills
'"I think Josh is a mature guy who has handled his responsibilities the right way," said Bills offensive coordinator Brian Daboll. "He works hard. He improves. He listens to the veterans and coaches. If he makes a mistake one day, he works really hard to try and fix it the next day. He has the right attitude."'
Bills long snapper goes viral
'The 24-year-old was signed as an undrafted free agent out of LSU and placed on the Bills practice squad in 2016. He was the Bills long snapper every game last season.'
Camp Countdown: No. 17 – What should we expect from Josh Allen?
'"Always smiling. Positive energy," said Ray-Ray McCloud of his draft classmate. "You won't catch him not smiling. That's all he does is smile. I met him at the combine and it was a serious moment, but he had that smile. When we're here, even off the field, he'll be like, 'What up Raymond?' He'll say my real name, so I'll do the same and go, 'What up, Joshua?' But he's a fun dude to be around and he brings positive energy."'


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Recruitment-Recruitment Process Design
Clicking apply will take you to the company's website
Roles and Responsibilities
Job Skill: Recruitment Process Design
Designation: Career Level - 10-Analyst
Location: Gurugram
Qualifications: Any Graduation
Years of Experience: 5-7 years
Desired Candidate Profile
Job Summary
You will be aligned with our Human Resources vertical and help us in the function that is crucial for the organization that deals with the people and issues related to people such as compensation and benefits, recruiting and hiring employees, onboarding employees, performance management, training, and organization development and culture. You will be working as a part of Recruitment team which uses Talent Supply Chain Management approach to securing and optimizing talent supply and services through all input channels to meet the workforce needs of Accenture, enabling them to meet their strategic objectives. Recruitment Process Design includes finding and hiring the best-qualified candidate (from within or outside of an organization) for a job opening, in a timely and cost effective manner. It includes analyzing the requirements of a job, attracting employees to that job, screening and selecting applicants, hiring, and integrating the new employee to the organization.
Roles and Responsibilities
In this role you are required to do analysis and solving of increasingly complex problems. Interaction is with peers within Accenture before updating supervisors. Likely has some interaction with clients and/or Accenture management. Minimal instruction on daily work tasks and a moderate level of instruction on new assignments will be provided. Decisions made by you impact your own work and may impact the work of others. In this role the person would be an Individual contributor and/or oversees a small work effort and/or team. Please note that this role may require you to work in rotational shifts.
Perks and Benefits
Salary: Not Disclosed by Recruiter
Industry:IT-Software / Software Services
Functional Area:HR, Recruitment, Administration, IR
Role Category:HR/ Recruitment / IR
Role:Recruitment Executive
Employment Type:Full Time, Permanent
Desired Candidate Profile
Doctorate:Doctorate Not Required
Company Profile
Accenture Solutions Pvt Ltd
Contact Company:Accenture Solutions Pvt Ltd
Address :Plant No-3.Godrej and Boyce Complex, MUMBAI, Maharashtra, India
Reference Id:38907


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About Us
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Wings Maker FC-16 Cell EDF
Ultimate EPJ10 Special Show EditionSky Nova 2Pre Assembled Combo
See E.P Ogar Kit EPO*
Ogar EP BL Combo**Wing Bags Included
The World ModelsFull Range
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Until now the FPV experience was complex and very expensive, only really achievable with serious endeavour, time and dedication. Hubsan's new Skyhawk FPV does all the hard work for you and provides a completely ready-to-fly package than can have you up and flying in a matter of no time. Simply glue on the tail-pieces, charge the battery and take off!
Made from sturdy crash resistant foam it features a built in stabilisation system making it a perfect choice for the beginners and/or experienced flyers. Once airborne you can view the world from above via the front mounted 5-mega pixel camera that shoots live video directly to a 3.5" LCD monitor on the transmitter
in colour.
Only The Beginning
Upgrade your flight experience with add-on modules coming soon:


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By Mas RodinIn Alternative Medicine, Amulets & Talismans Posted
Dark and Fragrant Oil for Allurement, Healing and Ritual Magic
An authentic Indonesian potion actually needs no further introduction. Indonesia's magical oils are internationally recognized as genuine treasure troves of ritual magic. This dark and fragrant oil is precisely what you would expect from an occult charm. It is made and blessed by dukun (shaman), using consecrated olive oil as its main ingredient, which was […]Read More


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Research Innovation and Enterprise award
The Research Innovation and Enterprise Award recognises a UWA researcher who has applied learnings from their scholarship to develop an innovation solution to a real-world problem. It seeks to celebrate knowledge translation through research enterprise, entrepreneurship and/or industry engagement.
- Test For Real-time Detection of Resistance in Weeds
- Roberto Busi, Australian Herbicide Resistance Initiative (AHRI)
- A New Highly Sensitive, Diagnostic Method for Leukaemia
- Wendy Erber, Kathryn Fuller and Henry Hui (Faculty of Health and Medical Sciences, Biomedical Sciences)
- A New Surgical Treatment for Glaucoma
- Dao-Yi Yu, Lions Eye Institute Physiology and Pharmacology Research Group, Centre for Ophthalmology and Visual Science (COVS)
UWA Innovation Champion
The UWA Innovation Champion Award recognises a researcher or staff member who has demonstrated a sustained commitment to promoting a culture of innovation, enterprise and industry engagement at UWA.
- Melinda Hodkiewicz
- Mechanical Engineering, Faculty of Engineering and Mathematical Sciences
- Kevin Pfleger
- Head of Molecular Endocrinology and Pharmacology, Harry Perkins Institute of Medical Research
- Liang Cheng
- Civil, Environmental and Mining Engineering, Faculty of Engineering and Mathematical Sciences
- Adrian Keating
- Mechanical Engineering, Faculty of Engineering and Mathematical Sciences
Student Startup of the Year
The Student Startup of the Year Award recognises and celebrates innovative enterprises launched by UWA student entrepreneurs.
- Futuristic: Skills of the Future
- Conor Mclaughlin (Data Science student)
- Unearthed: Empowering through Expression
- Taj Dutton (Arts/Business student)
- I Can and I Will Project
- Kishaini Baskararao (Medical Science student)


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News Details
With a view to ensuring safety of women, women's police stations would be set up at sub-divisional level on the pattern of those already established at district level, after completion of police recruitment: CM 13-08-2016
- Chandigarh, August 13 – Haryana Chief Minister, Mr. Manohar Lal, said that with a view to ensuring safety of women, women's police stations would be set up at sub-divisional level on the pattern of those already established at district level, after completion of police recruitments.
- The Chief Minister was speaking at a public meeting at Kalayat in district Kaithal today.
- Accepting a long-pending demand of the people of the area, he also announced to make Shri Kapil Muni Mahila College a government college. He also announced construction of a mini secretariat in Kalayat sub-division and rest house of Public Works (Buildings and Roads) Department. Apart from this, a stadium would be constructed over an area of six acres and a general hospital would also be established. He also announced that all pilgrimage sites in district Kaithal, including Kapil Muni Tirath in Kalayat, would be restored by the Kurukshetra Development Board.
- He also announced Rs 30 crore for construction of 10 roads, Rs 10 crore for other development works in rural areas, and Rs five crore for municipal area. He said that sewerage and other amenities on the pattern of cities would be provided in five villages with population of over 10,000 in Kalayat Assembly Constituency. He also announced to give Rs five lakh each for 'gaushalas' of Kalayat, Bata and Khadalwa.
- He said that under the new Enterprises Promotion Policy-2016, special grant would be provided to backward areas of the State in four categories. Under this, Kalayat area has been included in Category D. A development scheme is also being prepared for Kalayat under which a sector of Huda Urban Development Authority (HUDA) would be developed where people would be provided amenities at par with big cities. He also announced construction of building of powerhouse and increasing the capacity of transformers, besides construction of a community centre and reconstruction of drains and two bridges on the road leading from local anaj mandi to railway station.
- Union Minister of Steel, Mr. Birender Singh, Haryana Finance Minister, Capt. Abhimanyu, and Chief Parliamentary Secretary, Mr. Bakhshish Singh Virk, also spoke on this occasion.


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Air New Zealand has been trialling the use of Chip the robot to help with check in at Sydney Airport.
The black and white robot called Chip has two eyes, two ears, two arms but no mouth. He communicates via a touch screen on his chest to help customers at check in.
Chip was introduced to passengers at Sydney Airport on Monday. His eyes scan passenger's boarding cards after which he waves goodbye.
This is just an experiment from Air New Zealand for one week to see how passengers interact with robotic check in staff.


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COVID-19 Update
As of 9pm on the 27th of March 2020, the Irish Government have issued a Lockdown.
Update April 14th - the Irish Government have Extended the lockdown until 5th of May.
Update April 21st - We have received governmental permission to have one worker on the premises to ship orders to non-shipping affected countries listed below. We will be clearing the backlog and will continue to ship at a reduced rate.
This means that orders for certain countries placed on or before this date may not be able to be fulfilled by us until shipping restrictions have been resolved.
You may still place orders and enjoy the complimentary PDF that comes with all of our physical products, they will be shipped as soon as possible.
If you have any questions about this or an existing order - please email email@example.com
This update will be updated regularly and the below information is still relevant for when the shipping restrictions are lifted.
We are taking precautionary measures when handling goods, wearing disposable gloves, wiping surfaces and washing hands regularly. Our delivery partners also have strong COVID-19 measures in place, for example DPD have changed to contactless deliveries - see here for more.
Due to international flight and local suspensions we can only fulfil orders via Standard Shipping to the following countries:
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Dave Kearns is like many of us in Florida.. absolutely fed up. He is so angry at Scott's antics he wrote a book entitled Rick Scott: Enemy of the State. Kearns is also responsible for bringing to light Rick Scott's Ditchgate, where he literally stranded families in the woods to avoid questions. David has been a former professional journalist and a teacher who wants what everyone in Florida wants: to bring sanity back to the Florida legislature and rehabilitate our state's horrible reputation.
There are thinking, feeling human beings in this state and our voices are being drowned out by the FOX noise machine, and well-funded reactionary republicans who have usurped out state's government.--David Kearns
His opponent, John Tobias, is a homophobe who mocks gays and, according to the Orlando Sentinel, makes "inappropriate comments about women." He only won by 2% points.
David Kearns is the independent in the race. I normally go for the Democrat, but in this case, I can't support the Democrat, Santa Isabel Wright, because of her passive campaign philosophy. You need someone who will get angry and fight. It's time to start pushing back.
Volunteer or contribute at "668 Dunbarton Circle Ne Palm Bay Florida 32905" making check to "The Committee to Elect David Kearns". He accepts nothing greater than $1000 per donation.


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Pavla Models 1:72
|CMK (Czech Master Kits)
|Aichi M6A1-K Nanzan
|Full kit
|199x | Initial release - new tool
|Aichi M6A Seiran » Propeller (Aircraft)
None of our partner shops or mates has this currently for sale.
We don't know about any in-box reviews for this Aichi M6A1-K Nanzan (#) from CMK.
by Dick Powers on J-Aircraft.com
by Kevin Drake on J-Aircraft.com
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Layne Staley Led Alice in Chains In One of the Band's Most Difficult Tours!
Alice in Chains would open for Slayer, Anthrax and Megadeth during the US leg of the "Clash of the Titans Tour." Today we talk about how the band ended up on the tour and how they survived it. Check it out below!
John Frusciante Praises Kurt Cobain's Guitar Playing
Former Red Hot Chili Peppers guitarist John Frusciante discussed the secret to late Nirvana frontman and guitarist Kurt Cobain's guitar playing in a newly published interview with Ultimate-Guitar's Steven Rosen.
Frusciante claimed, "I'm more interested in doing things texturally with the guitar and trying to come up with ways of playing that I find interesting. And for me, the rock star guitar soloing approach is a dead end. I don't see that many people ever taking it anywhere. And to me, the most interesting guitar players that we've had over the last twenty years have not been soloists.
They've been people like Bernard Sumner from Joy Division and New Order, Johnny Marr from The Smiths, Johnny Greenwood in Radiohead, Kurt Cobain in Nirvana … none of these people were soloists. These people all did interesting things with their sound and they do interesting lead guitar things but it's not flashy.
To me that guitar playing kind of reached a peak with Jimmy Page and I don't really think anybody's ever taken it any further than Jimmy Page. Eddie Van Halen, I thought went to an interesting place with it but again I don't think it ever went anywhere from there."


text: Today in sunny Florida I took the time to drive down to the beach & take some practice shots. I am working on learning how to properly set my ISO, Aperture & Shutter Speed all at the same time on manual mode. The above photo was taken with a 50mm, ISO 400 and a F6.3.


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Pool photo by Indigo; Lisa Mauceri/Splash News; Tim Whitby/Getty Images
A look at who's staying cool and looking cooler this season.
The printed suit, as seen on the runways at Prada, Miu Miu, Rag & Bone and Rochas, got a head start on the fall season, with celebrities, models and designers stepping out in versions of the look as early as last week. Here, the designer Stella McCartney wears an allover brocade in glowing blue at the Creative Industries Reception at the Royal Academy of Arts in London; Gwen Stefani is spotted (pun intended) on a stroll in New York; and the model Tali Lennox shows that head-to-toe roses can really grow on a girl.


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In a separate pan fry bacon to desired degree of crispness.
Spread Better Than Good Bacon Jam on inside of Onion Rolls and place grilled patty on bun and then top with as much bacon as you want. Yummy! The Cheese is optional.


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|All photos by Rick Lamplugh unless otherwise noted.
As wildfires rage across the West, I'm reminded of their frightening power and ecological necessity. Last summer Mary and I had the chance to hike into and explore the site of a Yellowstone wildfire. We saw the destruction and creation wildfire brings.
Crossing the Gallatin National Forest boundary, Rich, Mary, and I start our hike into the heart of where the Little Joe Fire once burned. But hike is the wrong word. We have to climb over, squeeze under, and tightrope walk across fallen snags. We weave through standing snags and push past new-growth pines. Sometimes the stark contrast of death and life—scorched black trunks and bright green new growth—stops me in my tracks.
We struggle to follow a trail that has not seen much use in the years since the Little Joe Fire. Eventually, we escape the maze and reach an overlook with grand views of Emigrant Peak; Ash, Sheep, and Dome Mountains; the town of Gardiner; and a glimpse of Paradise Valley.
We can also see the gravel road near Beattie Gulch where at 5:30 this morning we parked our cars, prepared our mountain bikes, and stood in silent admiration of the bugling of elk. As we started cycling up that gravel road, we spotted a group of about 25 elk and calves grazing a quarter-mile away. Several females held their heads high and monitored our approach. As we rode toward them, the elk hustled over a ridge and out of sight. We cycled on, heading for the Northeast Electric Peak Trail.
Yesterday, moving a fingertip along a map, our route had looked simple enough. We would cycle up the gravel road to a point where it has been abandoned and left to degrade to a trail. After about four miles of cycling up the flank of a mountain, we would ditch our bikes and continue on foot, maybe as far as the summit of Electric Peak.
But this morning, when we had to dismount and push our bikes up the steepening grade, I was reminded of the reality of landscape versus maps. My hiking boots brushed sage and rustled up its invigorating aroma. We passed an overgrown road on the left, and Rich surprised Mary and I when he said that the road leads to a cabin once owned by millionaire Malcolm Forbes.
Once the grade lessened, we remounted the bikes and slogged through switchbacks. We passed a pile of fresh bear scat and then another. I fingered my bear spray. As the grade increased we rode less, pushed more. Panting and wiping away sweat, I was reminded that there's nothing like a mountain to teach humility.
After we lifted the bikes over yet another downed tree that blocked the rugged road, we had had enough "cycling." We laid our bikes in the downfall that covered the road and proceeded on foot.
About a mile or so later, Rich admitted that the trail did not look familiar. He had taken this route twice before, but the last time was more than a decade ago. We unfolded the map and located the abandoned road and what we hoped was our location. Semi-satisfied, we continued hiking and soon spotted the roof of a cabin on a slope above us. Rich did not recall that cabin, which could be recent construction in this patchwork of public and private land. Finally, we arrived where the road ended and a rusty sign proclaimed that we would enter Gallatin National Forest again. The slope we faced was cluttered with downed timber, blackened snags, and young pines. Rich smiled and said the trail to the summit of Electric Peak should be just ahead.
That trail might reach the peak, but we would not. As it turned out, we had found the day's destination, the site of the Little Joe Fire, a little known but exceptional fire from years ago. This recovering burn invited us to stay and learn about fires and their aftermath.
On August 25, Christopher Kelley and some friends were enjoying a hot Saturday afternoon when they spotted a smoke column near Little Joe Lake. The fifth major blaze of Yellowstone's 2001 fire season had sparked to life.
Officials jumped into action and determined that the fire threatened the Forbes cabin as well as a microwave tower. The incident commander told the Bozeman Daily Chronicle that they would fight to save the structures and suppress the fire in the mix of private land and National Forest on Yellowstone's northern border.
The call went out for help. Eleven aircraft, a 20-person hotshot crew, and fire engines from the small towns of Gardiner, Livingston, Amsterdam and Wilsall came running. Slurry-dispensing planes dive bombed flames which now engulfed the crown of a dense conifer forest. The planes also dumped retardant on the Forbes cabin; it survived the dump and would survive the fire.
But along with the firefighters came high winds that fanned the flames. The blaze headed south, spread to more than 150 acres, jumped the boundary into Yellowstone, and consumed the recently evacuated Deaf Jim Patrol cabin just off the Northeast Electric Peak Trail.
|Photo by Marc Moss via Flickr CC 2.0
Within two days more than 300 firefighters and support personnel were battling what had been christened The Little Joe Fire. Its billowing smoke was easily seen by tourists entering Yellowstone through the Roosevelt Arch. One hundred and forty firefighters, three bulldozers, and an armada of helicopters and tanker planes did their best, but the fire quadrupled to 650 acres, making Little Joe exceptional. According to NPS data, only about one in every twelve Yellowstone fires ever burns more than 100 acres. Most park fires never exceed a quarter-acre.
Investigators searching for the cause of the fire found a burned-up pickup truck near Little Joe Lake, where they think the fire started. They figured the fire had been human caused, which also makes Little Joe exceptional; lightning starts most Yellowstone fires, as it does elsewhere in the American West.
By September 3, nine days after Kelley and his friends spotted the smoke column, fire managers told the Associated Press that they had the fire under control. Little Joe had scorched more than 800 acres.
We start bushwhacking into the heart of Little Joe, climbing over, squeezing under, and tightrope walking across fallen snags. We pass occasional signs that identify the border of Yellowstone National Park, signs that Little Joe ignored.
We climb to 8,600 feet and find a natural meadow painted with sunshine and decorated with wildflowers. We stop to explore and appreciate nature's collage, especially the broad swaths of blue forget-me-nots. There is no evidence of the fire.
Leaving the meadow, we enter an obvious burn area. What was once a shaded forest floor is now a sun-drenched paradise that attracts the meadow's wildflowers. But everywhere we look, we find new tree growth. There are probably more trees growing here now than before Little Joe blazed through. Research after the big fires of 1988 found that where Yellowstone's dominant tree, lodgepole pines, burned, 50,000 to 1,000,000 seeds covered each acre of blackened ground. Those seeds had been enclosed in cones that are sealed with resin that requires fire's intense heat to melt. Having released the seeds, fire helps them grow by clearing the forest floor and opening the canopy. Eventually, the lodgepole pines will reclaim the sunlight, darken the ground below them, and send the wildflowers back to the meadow.
Lodgepole pine is just one of the many plants and animals in Yellowstone that survive and even flourish with fire. All have had a long time to adapt; wildfires have shaped Yellowstone's landscape since the last glaciers melted away about 15,000 years ago. Without those fires that create a mosaic of plant communities in different growth stages, this ecosystem's biodiversity and health would suffer.
Yellowstone's Fire Management Plan aims to continue fire's important role by allowing natural wildfires to burn with a minimum of human influence. On the other hand, the park is required to protect human life and the tiny percentage of Yellowstone's 2.2 million acres that are developed.
No doubt officials will have the chance to balance those conflicting demands as August temperatures increase, rainfall decreases, vegetation dries, lightning strikes, and wind blows. Smoke will darken the sky, flames will light the night, and people will worry that they are losing the Yellowstone they know and love.
But as the National Park Service reminds us, Yellowstone is not a museum—it is a functioning ecosystem in which fire plays an important role. A role that's obvious as we crawl and clamber through the heart of Little Joe.
To view a short slideshow with music of the birth of a wildfire.
To view a short slideshow with music of the birth of a wildfire.
Indie author Rick Lamplugh writes to protect wildlife and preserve wildlands. His new book, Deep into Yellowstone: A Year's Immersion in Grandeur and Controversy, is available signed from Rick, or unsigned on Amazon. His best seller, In the Temple of Wolves, is available signed, or unsigned on Amazon.


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Seoul: Won ends at 1-wk low, stocks nearly steady
[SEOUL] The South Korean won finished at a one-week low on Monday as the dollar stayed strong ahead of the US Federal Reserve policy meeting later in the week.
The currency was quoted at 1,147.8 to the US dollar at the conclusion of onshore trade, down 0.4 per cent from Friday's close of 1,143.1.
South Korean shares changed little, as foreigners' continued buying offset selling by domestic institutions and individuals.
The Korea Composite Stock Price Index (KOSPI) closed down 0.1 per cent at 2,014.55 points.
Offshore investors marked a ninth buying session, adding a net 221.7 billion won (S$262 million) worth of KOSPI shares on the main exchange on Monday.
BT is now on Telegram!
For daily updates on weekdays and specially selected content for the weekend. Subscribe to t.me/BizTimes


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This spot used to feature another piece painted in tribute of the Columbia Road Flower Market. Sadly, the new building developers boarded it up and hide the artwork behind an advertisement panel.
So I decided to paint it over and create a new image for the flower market: a portrait of a woman surrounded by roses. Roses have thorns, don't forget it!
Title: "Roses Have Thorn (Les Roses Ont Des Epines) – Zabou – 3x2m – London, UK – 2015


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Feeling worried about meeting her father for the first time? Don't worry, you're not alone! This is a resident fear of most guys who are set on impressing their girlfriend's dad.
Well, to be honest, it is not going to be easy!
She is his daughter, so he's got the upper hand here! Got it? But that doesn't mean you've got to be shit scared.
Few things must be kept in mind. It's best to be yourself on that very day, but don't forget that there are certain things which will make an impression even if its being yourself or behaving like it!
No, it's not the most difficult thing to do but be careful of not making stupid mistakes which he might take very seriously!
Here are six such points which will guide you through this journey!
6. Casual dressing – NOT at all! Present yourself as a gentleman even if you're not one
That's him thinking of ways to kick your ass. No kidding
So first things first; avoid casual and lousy dressing when you're going to meet him for the first time. The first impression must be bang on!
That will make him feel that you are not someone who's going to joke around.
For many, a man is known by the clothes he wears!
Not everyone might feel the same, but why take a chance?
Wear the best you have but overly dressed like this dude? No!
Work on your attitude along with what you decide to wear.
This will not only impress the father but your girlfriend (again!) and her mum too! You're important; why not make others feel the same about you too!
5. Talk less and focus on dodging bullets he's going to fire at you
Always remember that people prefer being listened to than listening! If it's a tough guy your girlfriend calls 'Dad,' you might as well listen to him as attentively as you did to a lesson on puberty in class 8th.
While most of you might not be chatterboxes but it is preferable to keep calm and be quiet mostly.
Talk when you're talked to but don't go overboard with it!
When he gives this reaction to what you say – he's actually saying 'What a looser' in his head
It's taken that you will be tense, so rather keep shut instead of blurting out unnecessary stuff.
For example: "You have beautiful furniture! I love the shape of her (your girlfriend's) bed!" Oops! Better keep mum!
And, here's a quick tip –
4. Avoid getting personal – he's not YOUR dad
Also See
This is one of the most important points to be kept in mind! No one likes being probed into by being asked personal questions. Avoid it to the core.
It gives out an impression that you're trying too much to know about his stuff! Come on, nobody likes being scrutinized! It's never going to sound fun to be asked, "Sir, you could use this (certain) oil to prevent from further balding"! No appreciation for this!
Even if you're dying to help him out, do it later, not now!
3. Don't get too chatty with your girlfriend's mother – NEVER!
Mothers (in most cases) will be easier to handle than fathers! While that is good news, you must also keep in mind that being too friendly with the mother might land you up in the bad books of the father! He will of course not find it amusing to find you all happy and gay chatting with his wife! Not that you can't talk to her, but keep comfort aside for this day! Give him all the attention required! Who knows things might change for the good.
2. Tell him how he is the IDEAL MAN – Be subtle!
All of us love being appreciated! Even if your girlfriend's dad is a complete moron, he's not an exception to this rule.
So, stick this point in mind and don't ever forget to mention how you feel that he is the best man you have seen.
Tell him that he's the best human being, the best father (much to your annoyance!) and the best husband you've seen.
And don't forget to mention that you're aspiring to be like him one day! Just don't do it all at once, okay? And wait for some time until you develop some chemistry. He is not a toddler you can entice with your sweet talk so easily
1. Never Argue with Him – No Debates At all (no matter how inviting)
For all you opinionated guys, keep opinions and reasons aside. Vent them on Facebook, would you?
Today you are going to follow every other detail he says. You believe it or not – that's a different story. You listen to everything he says, nod in yes and speak only when you think he wants you to say something, got it?
His ideas might not match yours but all you need to do is "yes, yes…yes."
Don't go over the top in proving any point which goes against his ideas and opinions.
There is time for that later! Yeah, you'll have plenty of opportunities to do that. Just have some patience for some now. Surrender.
He will reject you right away if asked unnecessary questions. You might be the most uncomfortable person there but make him feel the most comfortable one!
All the best!