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Archive for May, 2019
There is no Tri?
Just reviewing. I did a blog on the 4th of May, saying I was finally clear of that evil bug. I'd made several false starts at training, only to be too weak to continue.
Since then I've done a bunch of rides on the Sufferfest, but on the easier setting, to get my fitness back. I did a few fast runs then decided to run a marathon. I did it, but it was so, so bad. I actually quit several times. I thought, 'Right, just get to the next mile marker and I'm turning around, I just can't carry on.' Then I carried on. It was a triumph of bloody mindedness and grit, but I just wasn't ready for it.
As usual I'd been starting swimming. Tomorrow. OK, the next day. I hate swimming and I'm really bad at it so I have a huge aversion to overcome.
Then, at the beginning of last week, I looked up when a TV series was returning (Stranger Things). The 4th of July. I thought, 'Great, that's only a month away…., hang on, my triathlon is the end of July! AAAAAGGGHHH!'.
I've done about 4 or 5 swims since my last triathlon, no long rides, and even my run fitness took a battering from that 6 weeks of terminal man-flu. And I had 9 weeks to get to 2.4 mile swim, 112 mile ride, 26.2 mile run.
Oh, and work have been stitching me up with long shifts again. Super.
So this week I've done 3 swims, 2 Sufferfest sessions and a few runs. I worked out a target-work-backwards plan. Then thrashed it. As usual. By the end of this week I was supposed to be up to 50 lengths of the pool. First swim I did 52 (in 40 minutes), second 62, third and hour, which I think was about 80 lengths or 1.2 miles. (I wiped the data before I had chance to confirm, but it was roughly that.)
Today I thought I'd see where I was by doing a half.
Being a Saturday there was no lane swim or adults only, so I had to go to an open swim session. I got half an hour's swim, 42 lengths (2/3rds of a mile) before all the parents and toddlers piled in and I had to quit. Then I did a hilly 62 miles on my bike. 3,156 feet of elevation. Some of them were killer steep, I did 43mph in an aero tuck down one hill (then had to slog back up). I need to do that run again and again. The hills killed me. I had nothing.
I wobbled back in the pitiful time of 3 hours 47.
Then I went out for the run. 13.1 miles. The first two miles I was quite happy. 8 minute miles, not too painful. Then it hit me hard. I was desperate to quit. I slowed the pace and ground it out. It was miserable. I was looking back at the period on the bike where I had nothing as golden pinnacle of joy.
I did it in 1.57.
The point is, the swim was barely getting wet before I had to quit, and the the other two times you can't just double for my tri time (which would be bad enough) I had nothing. I couldn't have kept up that pitiful pace for the second half. It took everything I had to finish the half marathon without quitting. I was in a world of misery. I think I'd have been walking if I thought I had to do another 13 miles.
So that's where I am. With 8 weeks to go.
Trying to draw positives from a nightmare-ish world of pain and fail:
I've set the bar today. OK, it was at ground level, but now I know where I am.
I've started swimming. The last three triathlons I was going once or twice a week. From what I've read consistency is the key, so I've worked out late (8pm- 10pm) swim sessions for 5 nights a week. If I concentrate on form doing shorter sessions 40 minutes to an hour, and do one long session a week, I should crack that. Maybe improve my time.
I totally need to work on hills on the bike. I think a lot of it was down to trying to do huge hills while still in an aero tuck, sat down. Sit up, pull on the bars, stand up!
The run should be my strength. I'll just have to concentrate on putting in some miles.
In other triathlon news, I treated myself to an all singing, all dancing, Garmin 735xt, triathlon watch. Counts your lengths in the pool, GPS for outdoor swimming, monitors your bike sensor to tell you power, speed distance, heart rate, etc, and the same on the run. And it has a 15 or so hour (with GPS on, which really drains batteries) battery life. More than enough for my tri. Last year I bought a Timex Ironman watch. Iron distance tri-s have a cut off of 16 hours. The battery died half way through my run.
I got it as an early present for my birthday, two weeks ago. I took it for two swim sessions, I didn't even use the swim features, it was just sitting on my wrist as a watch, after the second session it started buzzing, then turning itself off. By the next day it was dead.
I've returned it for a swap, but if it happens again I'm getting a refund.
Total downer, it's an great watch.
Right, I'm going to bed. I've had enough of today.
Change and about.
It's been a strange time.
Work are introducing spy cameras into the trucks, against the express wish of every driver there. I got into a principled huff and have been looking for other jobs. I applied online to Royal Mail, Chorley, but didn't make it past their online personality test thing. Then I saw two other jobs that looked OK. I applied for them, and got invitations to go further, but then I found reviews. It's not just Amazon that do online reviews anymore. These were from actual drivers, past and present. The first job is a total lie, with terrible kit and long hours, being treated like dirt. The second, which looked on the advert to be local drops, loading and unloading your own trailer, good money, and most importantly only 8 hour shifts, was nothing of the sort. Long, long shifts, bullying culture, treated like crap, admittedly the money is still good.
I was getting a bit low but I think I'm bouncing back. It's not that my job is ideal, but it's still SO much better than the alternatives. I'll keep my eyes open, if Royal Mail, Warrington, advertise I'll be all over that, but I'm not leaving my job for a worse one. I mentioned that I was looking for other work to a trainer at work today. Because of the spy cameras, but also because I never know when I'm going home. He had a good suggestion. Ask to be trained as a shunter. They are the drivers who stay in the yard all day, moving trailers around. A tedious job but one with fixed hours. I could be on the good money I am on now and know when I was going home. And it would remove the other, otherwise unavoidable, irritant in my job; traffic.
It's certainly worth an ask.
Another downer is my bike. I bought the red one because it did everything the black on did and had great bodywork so looked fantastic. I got to work a few days ago and noticed half of a fairing panel was missing. It's completely inexplicable. If it had been a full panel I would have thought it had fallen off or been nicked, but half was left behind as though it had snapped off. but there were five bolts holding the snapped off bit in place. I haven't crashed it or dropped it, there is no plastic debris at ours, so not kids vandalising it. It makes no sense. Gutted though.
I spent hours searching for a replacement fairing panel. It's a 24 year old bike, and apparently left hand side ones are most sought after from people getting it wrong with the sidestand and dropping it. Found one, tried to buy it but eBay said there was an error, so I went back and tried again but it had sold. I found another panel and bought that. Then eBay sent me an invoice for the first one. It was a glitch, it had sold to me. Super. Still, I couldn't get either panel in red, so one will do while I get the nicer one sprayed.
In training news I'm pretty sure the wellness has taken this time. I've had about 3 false starts since the lurgy where I thought I was all well, did a bit of really tough, very poor, training, only to be weak and useless a few days later.
I did two workouts on the bike, the first followed by and 18 mile run, then tonight managed my first attempt at a fast run session in about 6 weeks.
I've had sports watch envy for a while. I got the Timex Ironman watch last year, when you turn the GPS on it drains the battery, the same with every watch, but the so-called Ironman watch died completely half way through my marathon at the end of my tri last year. The cut off point for Iron distance tri-s is 16 hours, I finished in 13.17, and the battery was dead long before that. Not a lot of use then. Since then I've been using my old, brick-sized Garmin watch for runs and the Timex as normal watch.
Wendy was asking me what I wanted for my birthday, so I've upgraded and got myself a Garmin triathlon watch. The battery is supposed to be good for 15 hours plus with GPS on and other data devices streaming to it.
It arrived today so I forced myself to go for a run to try it out.
You can set it with 4 data metrics on display or one big one per page. That is ideal for me. I need readers now, so 4 little readouts are no good to me unless I want to run in glasses. The one big display is clearly legible.
My old Garmin took a few minutes to find the satellites, so if I'd been on the bike I was cooling off waiting to start running. The Timex sometimes couldn't find the satellites at all. My funky new watch I pressed the run button, it instantly connected! Ace.
I monitors your heart rate on your wrist to an acceptable degree, but comes with a chest strap heart rate monitor for exact results. So far this afternoon/ evening, my lowest resting heart rate has been 47bpm. I'll be interested to see what I score overnight!
The grooviest thing though, is when I uploaded the run data. SO MANY METRICS! ALL THE STATS!
Usual stuff, route, elevation, pace.
Heart rate. But then, Stride Length, Run Cadence, Vertical Ratio, Ground Contact Time Balance…
It goes on. Steps Per Minute, Heart Rate As Percent Of Max, Average Vertical Oscillation…
I don't even know what half of this is, or how I could possibly improve it, but it's FUN!
As someone said on one of the reviews I was obsessively reading whilst trying to decide which model was best for me, "Why do we need all these stats and data? Because it's like catnip to a triathlete."
Or words to that effect.
I almost forgot in the new watch excitement, after struggling for a few weeks to stay under 8.30 m/m I did that short run tonight, but decided to try and be quick. I managed two miles under 7 m/m! That's more like it! At someone's suggestion on Twitter, I've bought a highly recommended book that people rate to get you under the 3 hour marathon. I'll start on that tomorrow.
Right, just a quick catch up.
I don't want to speak too soon, I've made several false starts recently, but I think I'm finally free of that bug.
It's taken forever. For the last 3 weeks I've thought I was over it, gone out for a few training sessions, then felt as weak as a Southerners cup of tea.
It's been dire. Also, there's the knock on effect of losing your mojo. While you are training and pushing yourself you are determined to be better the next time. After you've spent a while being lazy you know how bad it's going to be getting going again and you start avoiding it.
After my last blog, lamenting how utterly terrible everything was, I'm back to optimistic today.
I've had to switch off the 4DP setting on the Sufferfest (cycling training app thing) that is tailored to my exact strengths and weaknesses (well, weaknesses and slightly less weakness) until I can get my fitness back.
It's still set to my maximum sustainable effort, so it beasts me, just not quite as much. Last week when I was feeling OK I did the longest session on there,1 hour 40 minutes of mixed sets. It was too much really, my knee felt like a balloon afterwards.
Today I was cunning and just did a nice easy 45 minute session. Warm up, 1 minute hard, 1 minute rest. I can do this! Then again. By the third time I was thinking I was going to have to quit. But Sufferfest are sly. They give you just enough time to recover so you think 'OK, I'll just do one more' and keep going. 11 of them. Half way through they said "This is one of the most intense workouts you can do, treat it as such".
Nice, easy, 45 minutes my fat, lazy arse!
Then after the 11 sessions it got hard.
15 seconds of high revs, high power, sprint. Then 15 second rest. Times 20. It doesn't sound much, but there is no time to recover. Again, they are cunning, you can just about stop gasping then the next 15 seconds starts and you think 'Anyone can do 15 seconds!' so you push it out, even though you are still dying.
My admiration for the trainers at Sufferfest is total. They are evil,sadistic geniuses. The clue is in the name, I suppose. Their genius is in torturing you to the exact level where you push at your absolute maximum, but can finish without quitting. It really is where the Iron Crosses grow.
So I slogged through that. And it was terrible. But I did it.
Then I went out for a run. The last few weeks that has been slow and painful and maximum effort just to keep going. Today the first 4 miles were a joy. I just set my legs to running, and they kept it up, at a modest pace, with metronomic ease. That was a double joy as after the sufferfest being so hard I thought my legs would be shot. By about 9 miles my calves started really cramping. I think that's going so hard on the bike after a bit of a lay off. I kept it going and managed 18 miles. Not too shabby for a tester, recovery run.
My calves are still aching and set, but I'm back in the game!
In other news, I've started looking for another job. Work is getting me down. They're introducing spy cameras into the cabs, that are active even when you are on your break. It's not so much the cameras as the principle. They know the drivers don't want them, we voted for strike action rather have them, and they just don't care. The thing that really gets me down about my job though is never knowing when I'm going to be coming home. I just assumed that was the case for all lorry driver jobs. Then I saw the Royal Mail were advertising. I thought they only took on through the agency. Loads more money, and short shifts. But nights. Then I saw Aldi were recruiting. Nights, sadly, but 8 hour shifts, doing local runs to the stores then unloading yourself. They say you only spend 40% of your time driving. Most drivers are fat and lazy and would hate that. I reckon that would suit me. Even on nights. If you're doing locals it's less time on closed motorways, you're not falling asleep driving long distances, and you have a fair idea of your finish time. That all sounds good. Also it's only a 40 hour week and it's more money per hour. If I can get in, get my feet under the table, then look to transfer to days if any jobs come up, it would be perfect. I've applied, got through the first sift, and have an interview in a couple of weeks. See how it goes.
I've sold my black VFR750, only got my new (24 year old!) red VFR750 now. One bike.
Like. A. Caveman.
I've started a running/ triathlon/ cycling/ motorbikes account on Twitter. My old account has become enmired in politics. All the fun, whimsy and interesting stuff has been drowned in polemic vitriol. My new account has left me with watch envy though. I bought the Timex Ironman watch for my Iron distance tri last year. My Garmin GPS watch was good but old and only really good for a marathon or so before the battery died. Anyway, you buy a watch that's specifically branded 'Ironman', you expect it to do the business. I started it at the start of the race (naturally) fully charged, and it died half way through the marathon at the end. My overall time was 13.35 or something, the cut off time for the race is 16 hours. An Ironman watch that won't do Iron distance. Super. All the runners and tri people on Twitter have been showing off their swanky watches. It's my birthday in a couple of weeks and Wendy was asking me what I want, so I've bought an upgrade Garmin! Yay! Supposed to be good for 15 hours or so with the GPS on. More than enough time for me. And it finds satellites in no time. My old Garmin, bless it's long service heart, leaves me standing around for 5 minutes, cooling down and setting from the bike, before I can start my run.
So that's where I am.
If I don't feel weak and I can get back to training I still hope to achieve my goal for this year, which is an hour off last year's tri. I have 3 months to make it so.
I so hope that's it. That I'm back to normal now.
Right, bed time.


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Been mentioned several times now the O's may consider hiring a President of Baseball Ops.... and a EVP of Baseball Ops / GM.
If that's the case, clearly the hiring of the President has to come first.
We (BSL) have looked at a few prospective hires for EVP / GM; but the talent pool for a 'President' would be a bit different.
We're talking about guys who are not up and coming prospective GM's, but accomplished GM's.
They set the tone and direction for the Baseball Ops department, but the GM runs the day-to-day show.
They also are the direct conduit to Ownership.
If you weren't hiring a previously accomplished GM to be the President.... then Ripken in this capacity could make some sense. I'd have the same reservations I've always had about hiring him, but this would figure to be the type of position which would interest him.
What other names could make sense here?

subset: commoncrawl


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Personal Coach And Nutritionist
Is it your vision to encourage others in attaining healthier, fitter life? In addition to Patanjali, other Indian-based companies are having success with naturals. The three companies highlighted right here all emphasize their connection to Ayurveda and natural components, as do others. Nevertheless, every of these three firms has chosen a unique option to promote its model as a way to distinguish itself in an more and more crowded marketplace.
Is it women' evening? If you realize you will be imbibing more than one drink, feel (and sip!) proper by at all times ordering water between cocktails, says Newgent. That manner, you won't rack up sneaky liquid energy (and wreck your inhibition to resist those mozzarella sticks!). But your H20 would not should be ho-hum. "Make it festive by ordering the sparkling variety with loads of fruit, like a lime, lemon, and orange wedge in a martini or highball glass," adds Newgent.
Johnson made a name for herself because of her massive assortment of health DVDs. (She holds the Guinness World Report for probably the most fitness movies produced by an individual.) Now she's targeted on self-help and business coaching with an emphasis on attaining objectives whereas avoiding burnout. That is the mission of her common SmartLife Push Journal and her two prime-ranked podcasts , The Chalene Present and Build Your Tribe.
BodySpace is a social health platform that combines the advantages of digital personal coaching with the world's largest online fitness neighborhood. Decide a training program or begin with the proper exercise, and monitor all your stats to observe your progress. Meet and observe fellow BodySpace fans to remain motivated and linked. Learning how you can coach clients, patients, buddies, or members of the family by way of wholesome eating and way of life modifications窶琶n a manner that helps … Read More . . .


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Tag Archives: The Secret World
The Secret World tries something different… sorta…
I have, on record, lamented about the calcified state of the modern MMORPG, even as I continue to play The Old Republic (because Bioware). Old Republic turned out to be good enough from a story and setting perspective that I'm willing to overlook that … Continue reading
Posted in Armchair Philosophy, Level Up Tagged breaking from the pack, can MMO horror work?, MMORPGS, The Secret World 1 Comment


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A lawmaker said on Monday the recent attack by the so-called Islamic State (IS) terrorist group on the residence of the ambassador to Libya has been carried out in reprisal for its successive defeats in the region, and such moves will certainly end in failure.
"Daesh (the Arabic acronym for the Islamic State of Iraq and the Levant) terrorist acts against Iran are committed in retaliation for its recent consecutive defeats in the region," Shouhani said, adding, "Such measures are doomed to failure and will receive due response in the near future," ICANA reported.
The member of the Majlis National Security and Foreign Policy Committee noted IS attempts to harm Iran can be explained by the fact that "were Iran not present in the region, Daesh would definitely have seized Iraq and Syria."
Criticizing western powers for their support of terrorism to weaken Muslim countries, he said IS and its western and Arab backers aim to further their political and economic interests in the region through creating tension and instability.
"Creating crisis for the resistance front (against the Israeli regime) is the clear reason behind the formation of takfiri terrorism," he added.
A takfiri is a Muslim who accuses followers of other faiths and some Islamic sects of being unbelievers.
Two bombs went off at the gate of the ambassador's house on Sunday in the Libyan capital Tripoli. The Islamic State claimed responsibility for the attack, which left no casualties.


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By Vaughn Hoisington | USA
The FBI announced that all text messages from anti-Trump agents Peter Strzok and Lisa Page from Dec. 14, 2016 to May 17, 2017 were lost, in a letter sent from the Justice Department to the Senate Homeland Security and Governmental Affairs Committee.
The disclosing letter from the Department of Justice states that while 384 pages of text messages between the two agents were produced, "the FBI's technical system for retaining text messages sent and received on FBI mobile devices failed to preserve text messages for Mr. Strzok and Ms. Page" for approximately five months.
Misconfiguration issues on FBI-provided Samsung 5 mobile devices were blamed for the failure to store text messages.
Both agents had been members of Robert Mueller's Special Counsel for the Trump-Russia investigation. Strzok, the deputy chief of counterintelligence, had a high-profile position in the investigation, as he oversaw the investigation.
Strzok was removed from the investigation in July 2017, after it was revealed that he had made distasteful comments about Trump to Page, who had left the council shortly before the text messages expressing bias were discovered.
In a letter from HSGAC Chair Ron Johnson to FBI Director Christopher Wray, Johnson calls the loss of these records "concerning," since both agents "communicated frequently about the investigation."
Johnson went on to voice his concern about discoveries found in the 384 pages of text messages that were able to be produced.
One chain of texts pertaining to Director Comey's statement about Secretary Clinton emailing President Obama from a private server while abroad, expressed that FBI officials edited the draft, to replace "the President" with "another senior government official." Any mention of either Obama or the edited title was later removed from the statement.
Another chain of texts implied that Attorney General Lynch knew Comey would recommend that Clinton not receive criminal charges, before announcing that she would consent to any recommendation the FBI made.
The text messages also insinuate that both agents had engaged in a discussion of FBI business over non-FBI-issued devices.


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Laval-Mille-Iles District is super happy to have eight All Star Cookie sellers this year. It's the most we've ever had in our district!
As we know, cookie selling is sometimes a daunting thing for Girl Guides. It pulls them out of their comfort zone. So how did these girls do it? I took a few minutes and asked 6 of them.
8-year-old Dakota said: "Be polite, and also ask them politely without being rude or anything."
12-year-old Kira said: "Smile!"
10-year-old Erin said: "Smile, be polite and also say 'Hello.'"
9-year-old Khloe said: "Give them cookies [samples]."
9-year-old Gabby said: "Don't be scared!"
And 9-year-old Reiley said: "Well, there were a lot of things..because I was polite [and] they knew my parents or my aunt, one of them took a whole box [case].
The next big question was: "So do you girls think you can do it again next year?"
All: YES!
Some girls find cookie selling hard but these girls proved that with a polite and positive attitude, a beautiful smile, some sampling and a little help from their family, any girl can be a Cookie All Star!
Blog post submitted by Sheryl Quimpo. Sheryl is a Guider with the 1st Argenteuil Sparks and the 1st Two-Mountain Brownies.


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Turkey Pasabag (Valley of the Monks)
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Pasabag (Valley of the Monks)
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Triggered aggregation of PbS nanocrystal dispersions; towards directing the morphology of hybrid polymer films using a removable bilinker ligand
Rhodes, RW, O'Brien, P and Saunders, B (2011) Triggered aggregation of PbS nanocrystal dispersions; towards directing the morphology of hybrid polymer films using a removable bilinker ligand Journal of Colloid and Interface Science. pp. 151-159.Full text not available from this repository.
Hybrid polymer films consist of quantum dots (QDs) dispersed in a polymer matrix. A key fundamental challenge that is hindering their optimisation in optoelectronic devices such as hybrid solar cells is overcoming uncontrolled aggregation of the QDs. In an effort to direct aggregation, and trigger self-assembly, we added a bilinker ligand (1,2-ethanedithiol) to dispersed PbS QDs in polymer solutions prior to film deposition by spin casting. Turbidity studies of the PbS QD/1,2-ethanedithiol dispersions enabled a relationship to be established between the extent of 1,2-ethanedithiol-triggered QD aggregation and the nominal fractional coverage of the QDs by 1,2-ethanedithiol. The extent of aggregation (and self-assembly) increased with nominal fraction coverage. Above a value of about 1.0 QD aggregation increased substantially. TEM images showed that at low 1,2-ethanedithiol concentrations triggered assembly of network-like QD structures occurred. At high 1,2-ethanedithiol concentrations the QDs self-assembled into more-ordered micrometre-sized crystals. The results suggest that 1,2-ethanedithiol decreases the inter-QD separation in dispersion as a result of rapid ligand exchange and this process results in QD aggregation as well as self-assembly. The assembled QD structures were successfully trapped within polymer films by spin casting of PbS QD/1,2-ethanedithiol dispersions containing added polystyrene or polytriarylamine.
|Item Type:
|Divisions :
|Surrey research (other units)
|Authors :
|Date :
|8 March 2011
|Depositing User :
|Symplectic Elements
|Date Deposited :
|17 May 2017 13:00
|Last Modified :
|24 Jan 2020 23:14
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Laverne Cox And Beyoncé Are Up To Something Sneaky
Prepare to see the Beyhive don orange jumpsuits for the forseeable future. Vanity Fair is out with a report that Laverne Cox is partnering up with Beyoncé on a secret project. But the deets – like much of what Queen B does – are pretty scarce. Laverne did, however, confirm there was something coming when she was on Access Hollywood Tuesday.
Yes it's true. I am collaborating with @beyonce on a new project. #QueenBey herself. More details Sept. 6. #Beyonce #TransIsBeautiful pic.twitter.com/oNtUu87tVA
— Laverne Cox (@Lavernecox) August 22, 2017
September 6?! Ugh, you mean those two are going to make the Beyhive sit through one last summer barbecue over Labor Day Weekend at boring Uncle Ferdinand's house before they can find out if this means Bey is going to try and add an Emmy to her award closet and don an outfit at Litchfield Prison? Please, this is Beyoncé. They need her, not the other way around. In her mind, she's totally throwing Laverne a life raft so people can forget about that legal drama she was on with Katherine Heigl on Memaw Pepaw Network…I mean, CBS.
While we don't know what in hell this partnership will be, the two did meet at the Grammys this year in just about the most Beyoncé fashion ever, per Laverne:
"I was like, 'I love you,' and she's like, 'I know you do…I love you, too.''And she's like 'Your Lip Sync Battle was amazing.' She had seen I did Destiny's Child."
Ha! You know it really just stopped at "I know you do" and then Beyoncé floated away and left Solange to do the small talk. Laverne said the key to wooing Beyoncé is to act serene and play it cool. Yeah, okay. It's apparent all you have to do is go on Lip Sync Battle and do a Beyoncé number in front of Chrissy Teigen to smoke Destiny's Favorite Child out of her fox hole. Channing Tatum did it, and she made a cameo. Laverne does it, and suddenly Bey is drawing up legal papers for a new venture. Shit, Aaron Carter, you should go on and perform "Bills, Bills, Bills," and maybe she'll pay your AutoZone bill?
Pic: Wenn.com


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Date Posted:29/07/2015
Calcutta Brasserie in Stony Stratford is launching its second initiate to encourage guests to 'explore their palate' and sample new dishes; the new initiative is called the 'Curry Nam?n?' – meaning 'small sample'.
From 27 July, customers can ask to sample most dishes from the menu before they make their choice. A small sample pot will be brought from the kitchen for the guest to try a taster before deciding which dish to order.
"We want to give our customers choice and variety and allow them to try new experiences," says Restaurant Manager, Ali Ajmol. He adds: "You can go into a bar and ask to sample a wine or an ale so why not sample a dish from the menu. The portion will be very small but enough to give our customers a flavour of the dish without making any commitment to order."
Two months ago, Calcutta Brasserie launched its Combi menu where customers can order two main dishes from a set menu for one price. Again, designed to encourage people to try new dishes, the Combi menu has taken off and become a hit for weekday diners.
Now, the 'Curry Nam?n?' is available seven days a week and is only available on a selection of popular dishes.
Calcutta Brasserie, 7A St Pauls Ct, Stony Stratford, Milton Keynes, Buckinghamshire MK11 1LJ


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Dear All, This is my medical report. I am not taking any medicine. Kindly help me with your valuable suggestions..
I am Diabetic 2. controlled by diet and exercise.
Total Cholesterol 176 mg/dl
Triglycerides 70 mg/dl
HDL 50 mg/dl
LDL 137 mg/dl
Vitamin D 21 ng/dl
Vitamin B 12 188 pmol/L
Uric Acid 6.5 mg/dl
Lymphocytes 5%
Plateletes 182 (10^3/mm)


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Art & Finance report – highlights in the art market
Art & Finance Report 2019 – 6th edition
Since launching the initiative in 2011, we have seen the global art market ebb and flow: from the aftermath of the financial crisis to the peak of the market in 2016. In parallel, we have also monitored how the wealth management sector is increasingly responding to competitive pressures in its own industry, and the role art and collectible wealth are playing in the transition to a more holistic wealth management model.
Since our last report in 2017, external factors such as increasing political and economic uncertainty, rapid technological progress, climate change, and social inequality have dominated the headlines on a daily basis. We live in a changing world, fraught with uncertainty. This is the context in which we should view the global art and finance industry—the crucial intersection between culture and wealth.
We hope that this report will help to raise awareness


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Make a Gift
Individual Gift
- Make a monetary gift to the Library and support essential programs and services. Contact the Friends Foundation or stop into any CCPL branch to donate in person.
Memorials Make Lasting Gifts
- Are you looking for a special and lasting way to honor someone? Consider a commemorative book donation, in honor or in memory of a loved one or special occasion. Commemorative gifts can be made to a specific branch or on a specific topic. These items have a customized book plate with your message and are an appropriate tribute to a life well lived. To learn more about the Commemorative Book program, please contact Materials Management at 410-996-1055 x106.


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We Are Social
Equipment out your house or office with a desktop or All-in-One LAPTOP. Apple desktops mix power and magnificence. Social networking companies rely on energetic participation: users participate in actions and discussions on a site, and add, modify or create content. Students will examine an infrastructure design course of for securing computer systems and knowledge networks, as well as methodologies and finest practices for implementing security, security insurance policies, safety testing, and incident response.
Accordingly, programmers writing SaaS purposes might not should rewrite as a lot code as other programmers do and might instead spend extra time writing new programs. All through the course of the three-yr program, students shall be exposed to a number of programming languages and paradigms. The next table lists the Echo devices you can use with gadgets, and which Bluetooth protocol(s) the Echo units help.
Because of developments of their very own field, computer and knowledge expertise college students can now earn degrees on-line that are very related in both content and supply as conventional on-campus applications. Digital media communication services have been particularly essential drivers for the subsequent-era Web technology design and creation.
In reality, Faculty Alternative has curated the Best Online Bachelor's in Sport Design Levels If affordability is your highest precedence, we have now additionally ranked the Most Reasonably priced On-line Game Design Degrees for 2018. Computer networking is typically thought-about a sub-discipline of electrical engineering , telecommunications , computer science , info technology or computer engineering , because it depends upon the theoretical and practical utility of these disciplines.
Social media platforms feature strongly on both firms' lists, and it's interesting to notice that Twitter continues to indicate strong ends in website rankings, despite its eroding consumer base (extra on that within the social media section beneath). With iOS 13, Apple has constructed its scanner right into the Information app, enabling you to rapidly create PDFs with your iPhone and do more with them.


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Reminder: SunRail Running December 17
Sanford – Special Saturday service on SunRail, a pilot program by the Florida Department of Transportation, is being offered December 17, as a fun ride to shopping, holiday events and more. This special service is a privately funded initiative.
SunRail service begins with the first train leaving southbound from the DeBary station at 1 p.m. The last northbound train leaves the Sand Lake Road station at 10:45 p.m. and arrives in DeBary at 11:48 p.m. Regular fares apply. Please visit www.sunrail.comto see the entire Saturday schedule.
SunRail urges riders to get to the stations at least 30 minutes early, especially if you are purchasing tickets at the vending machines located on the platforms. If you are making LYNX bus connections, please be advised LYNX Saturday service may differ from regular weekday service. Please check the Saturday schedule at: www.golynx.com.
For more information about SunRail, including pricing, station locations, as well as the regular weekday schedule, please visit www.sunrail.com.
SunRail on Saturday Tips
· SunRail collects fares on Saturday
· Arrive at the station platforms at least 30 minutes in advance of your train
· Remember to tap on and tap off with your ticket, so your trip will register
· Please check the SunRail schedule at www.sunrail.comto make sure you don't miss your train
· If you are using LYNX to make downtown or other connections, please check LYNX bus schedules to see what time buses run: www.golynx.com
· No food is allowed on the train, nor is smoking allowed on the train and platforms
· Water, coffee and other non-alcoholic beverages are allowed, but only in secure, spill-proof containers
· Please be courteous to others, fold up strollers, store bikes properly as the trains may be crowded
· Please be careful around trains, railroad crossings, and while at station platforms. Be smart. Be safe.


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Keeping it Real
We've got about one month left before our follow-up health assessment at the Cooper Institute in Dallas for the GRFW Better U program. I'm not at all excited! In fact, I'm dreading it! I fell way off the program within the last 3 weeks or so and I keep promising myself to get back on and I just can't seem to motivate myself to do it. I have lost a total of 5 pounds - yep, that's it!!! I think that's pretty disappointing and I can't get out of that low. I have been eating better, and I'm exercising. I'm walking about 1.3 miles 4-5 times a week and sometimes I even come home and hit the treadmill. So, why have I only lost 5 pounds? It isn't making much sense to me at all.
I had small triumph this week when I finally measured my waist and I was pleasantly surprised that I've lost 1.5 inches - this is good news because I am back under the 35 inch threshold for concern about heart disease (ladies, you should be concerned about increasing the risks of heart disease when your waist is greater than 35).
To be honest, I would like to see more weight loss and more size lost and that's probably the anchor on my ankle. It's so easy to say just exercise more, but really, when in the world will I find the time. I leave at 8 in the morning and return at 7 at night. When I get home I'm exhausted and then I have to take care of home (and then I'm planning Blogalicious) so where am I supposed to find any more time in my day. Whatever free time I've been able to carve out I'm exercising so what's left? Once again, I'll hope that things can pick up soon.
Go on over to our Better U partner's site for her tips.


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Lecture Materials
21 May 2020 Lecture Slides - Arbitration Enforcement: Torn Between Two Treaties
Why do Fraud Lawyers Dislike Arbitration
Slide handout from the lecture on 24 March 2020 given by Richard Gillis QC, One Essex Court
Enough is enough? Setting aside a judgement for fraud - lecture slides
Slides from the lecture on 5 September 2019 The copyright remains with Neil Hext QC and Tom Shepherd, 4 New Square
Breaking ground in fraud recovery claims
Slides from the lecture presentation given by Paul Lowenstein QC, Twenty Essex on 9 July 2019. These slides are for reference only and copyright remains with Paul Lowenstein QC
Unfair prejudice petitions
Powerpoint Presentation provided by Daniel Lightman QC
LSLA Lecture Financial Litigation Review
Slides from the lecture on 13 February 2019 given by Sonia Tolaney QC
LSLA Lecture Securing Funding: Securing costs - 24/1/19 Slides
Slides from the lecture on 24 January 2019
Lecture slides - Brexit: A Legal Matter: A Difficult Divorce
Slides from the lecture given by Patrick Lawrence QC and Paul Fisher, 4 New Square on 13 November 2018
Breach of confidence remedies – key developments and difficulties - presentation
Powerpoint presentation from the LSLA lecture on 12 Decmeber 2017
Breach of confidence remedies – key developments and difficulties - handout
Handout from the LSLA seminar on 12 December 2017
Freezing Orders: Practical guidance on obtaining, resisting, policing and enforcing them
Slides from the lecture held on 12 July 2017, presented by Nathan Pillow QC
Under Siege - an Update on Legal Professional Privilege
Slides from the LSLA lecture held on 15 June 2017 and presented by Bankim Thanki QC and Colin Passmore
Making the Company Pay - Developments in Corporate Liability for Economic Crimes
LSLA lecture notes from Richard Lissack QC's lecture on 24 January 2017
Recent Developments in Banking Law and Practice
Slides from the talk given by Sonia Tolaney QC on 28th November 2016
What does Brexit mean for the Brussels regime?
Seminar slides
Recent Developments in Unjust Enrichment
Powerpoint presentation from the seminar held on 6 July 2016
Is there no stopping contractual estoppel?
Powerpoint presentation from the seminar on 21 June 2016
What does a commercial litigator need to know about human rights?
Hand out from the seminar given by Jonathan Crow QC on 7 June 2016


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SINGAPORE – Japan and Australia agreed Friday to make efforts to prevent their whaling dispute from hurting bilateral relations, a government official said.
During talks in Singapore, Foreign Minister Taro Kono briefed his Australian counterpart Julie Bishop about Japan's proposal to restructure the International Whaling Commission to make it easier to resume commercial whaling.
But Australia is strongly opposed to all forms of whaling, raising concern that ties between Tokyo and Canberra could be strained by a practice that Japan says is a cultural tradition.
Last month, Japan proposed resuming whaling of some species of relatively abundant whales. The government halted commercial whaling in 1982, in line with the global moratorium adopted by the IWC, but has hunted the mammals since 1987 for what it calls "scientific research purposes."
In September 2014, the IWC adopted a resolution saying Japan should abide by the International Court of Justice's ruling earlier this year that its "scientific whaling" program was illegal and should be halted.
Bishop and environment minister Josh Frydenberg released a joint statement on Thursday condemning the proposal to lift the global moratorium on commercial whaling.


text: AkAzaAkaza Cologne Sanskrit Dictionary: AkAza m. (Ved.) or (later) n. (ifc. f. {A}) a free or open space , vacuity the ether , sky or atmosphere ({am}) n. (in philos.) the subtle and ethereal fluid (supposed to fill and pervade the universe and to be the peculiar vehicle of life and of sound) Brahma (as identical with ether) L. ; = {AkAza-bhASita} below Comm. on e}) loc. ind. in the air (a stage direction implying something said by or to a person out of sight)


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As if sky-high piles of snow weren't bad enough, slippery slush and patches of ice litter streets and sidewalks, presenting hazardous conditions that could lead to a fall if people aren't careful.
"An invisible patch of ice is an accident waiting to happen," says Dr. Geoffrey Westrich, an orthopedic surgeon at Hospital for Special Surgery in Manhattan who has seen his share of injuries from a fall. It happened to 45-year-old Kenny Fields of Wantagh, Long Island. Last year, he fell in a parking lot and fractured three ribs. He had slipped on a patch of ice between two parked cars and was out of work for a month.
Dr. Westrich says everyone should exercise caution when the streets turn slippery this time of year. "People often forget how dangerous a fall can be, especially when they're in a hurry to get somewhere. Even if much of the snow and ice are removed, there are always some slippery surfaces to watch out for."
Dr. Westrich offers these safety tips:
- Wear shoes or boots that provide traction on snow and ice, such as those with rubber and neoprene composite soles. Avoid plastic and leather soles, smooth-soled shoes and, of course, high heels.
- Walk at a safe pace. Give yourself enough time to get to your destination without rushing.
- When given no choice but to walk on ice, take short steps or shuffle for stability.
- Look where you're going. Watch for icy patches, especially on the north side, that remain even if the sidewalk or parking lot has been cleared of most snow and ice. Areas that do not get sufficient direct sunlight, and spaces where snow accumulates (such as near roadside curbs or between parked cars) remain icy long after the rest has melted or has been removed.
- Footwear should keep feet dry, warm and comfortable and provide good support.
- Walk in designated walkways as much as possible. Don't take shortcuts or try to jump over piles of snow.
- Keep your field of vision clear. Hats should not cover your eyes. You should be able to close your coat sufficiently so you can easily see where you are going.
- Make sure belts and scarves don't drag on or near the ground where they can cause you to trip.
- Use a cane or walking stick to help stabilize your balance if you need to.
- Snow and ice accumulate on stairways. Always use hand railings. Look where you're stepping and place feet firmly on each step.
- When you're in your car, try to park where it is clear of snow and ice.
- Use special care when entering and exiting vehicles. If necessary, use the car for support.
- Do not overload yourself with packages. Anything that throws your balance off increases the risk of falling. Make several trips to the car to unload it, rather than carrying everything at once.
- Older people, who at particular risk of a debilitating fracture, should try to keep driving to daylight hours so that they are able to see patches of ice on streets and in parking lots.
- Remember that some medications, like allergy/cold medicines, certain painkillers, and others can make you groggy or dizzy, reducing your ability to maintain your balance on slippery surfaces.
- Be especially watchful for "black ice" – that almost invisible sheet of ice that forms after roadways thaw and refreeze. The road, sidewalk, or parking lot may look like they are simply wet, when in fact the thin ice on the surface is extremely slick.
- When entering buildings, remove snow and water from footwear to prevent wet slippery conditions indoors.
At Home:
- Keep walkways free of obstacles, such as snow shovels, other outdoor tools, sleds and other toys.
- Provide sturdy handrails on all stairways to porches or doorways.
- Spread a layer of sand, salt, gravel, cat litter, etc. to provide extra traction on the ice, and to promote melting.
About Hospital for Special Surgery
Founded in 1863, Hospital for Special Surgery (HSS) is a world leader in orthopedics, rheumatology and rehabilitation. HSS is nationally ranked No. 1 in orthopedics, No. 3 in rheumatology, and No. 16 in neurology by U.S.News & World Report (2010-11), and has received Magnet Recognition for Excellence in Nursing Service from the American Nurses Credentialing Center, and has one of the lowest infection rates in the country. From 2007 to 2011, HSS has been a recipient of the HealthGrades Joint Replacement Excellence Award. A member of the NewYork-Presbyterian Healthcare System and an affiliate of Weill Cornell Medical College, HSS provides orthopedic and rheumatologic patient care at NewYork-Presbyterian Hospital at New York Weill Cornell Medical Center. All Hospital for Special Surgery medical staff are on the faculty of Weill Cornell Medical College. The hospital's research division is internationally recognized as a leader in the investigation of musculoskeletal and autoimmune diseases. Hospital for Special Surgery is located in New York City and online at http://www.hss.edu/.


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Recruiting Experts
Job Details
Job Ref.: 5621
Job Title: Fire Sprinkler Fitter
Role: Technician / Maintenance
Relocation Available: No
Industry: Construction
Location: North Carolina
Town / City: Sanford
Job Type: Permanent full-time
Job description:Company provides Fire Sprinkler systems, installations, testing, monitoring, inspection and repair. Currently looking for Commercial Fitters with related experience.
Bottom Line Requirements:
1. Experience as a Fitter for Fire Sprinkler or Alarm systems.
2. Local.


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- Blog
- View recent blog entries
- Member for
- 10 months 4 weeks
- I Digress
- on 93.9, CICK Schedule Monday 3-5pm and Wednesday 8-10am.
- All Eyes on Her
- on 93.9, CICK Schedule Saturday 11:30am-12pm.
The Smithers Community Radio Society is an incorporated non-profit that manages a locally supported, volunteer operated community radio station. Our mission is to strengthen and enrich the Smithers community by delivering volunteer produced radio programming.


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The leap year cocktail has been around since the 1930s. If its name is not on the tips of all tongues, it is at least in the back of some minds and a well-rounded martini alternative. A wonderful mix of flavors with a classic style, this cocktail definitely deserves to be enjoyed more than once every four years.
In this recipe, you'll pair gin with sweet vermouth and the brandy-based orange sweetness of Grand Marnier. Adding a little lemon juice brings it all together, creating a cocktail that has an enlightening citrus tone. It's very easy to mix up and is an excellent choice for a dinner cocktail, either before or after the meal.
- 2 ounces gin
- 1/2 ounce sweet vermouth
- 1/2 ounce orange liqueur (Grand Marnier)
- 1/4 ounce lemon juice
- Garnish: lemon twist
Steps to Make It
Gather the ingredients.
In a cocktail shaker filled with ice, pour the gin, sweet vermouth, Grand Marnier, and lemon juice.
Strain into a chilled cocktail glass.
Garnish with a lemon twist.
Serve and enjoy!
- Top-shelf gin is the way to go with this cocktail. It relies heavily on that single ingredient and lays the foundation for the best-tasting drink.
- When it comes to sweet vermouth, ensure that it's fresh. If you don't mix with it often, that open bottle in your bar may be stale. Its shelf life is just 3 months once oxygen hits the fortified wine, so replacing old bottles is a good idea.
- For the orange liqueur, triple sec and curaçao will not do. This drink deserves a brandy-based, sweet orange that can only come from Grand Marnier or GranGala.
- The lemon juice should not be an afterthought. Fresh-squeezed juice is the final touch for a great leap year. Since the average lemon yields 1 3/4 ounces, you can easily make more than a few drinks with one piece of fruit.
- To maximize your fruit usage, cut the lemon twist before cutting the lemon open. You can then use that same piece of fruit for its juice.
Recipe Variations
There are a few similar drinks within the gin martini lexicon that are worth mixing up and comparing to the leap year.
- The gin and it is a simplified version that uses gin and sweet vermouth alone.
- The Emerson cocktail is a lesser-known variation on the popular Martinez (the gin martini's predecessor). Those two drinks opt for maraschino rather than an orange liqueur, though the Emerson includes the same lemon juice enhancement as the leap year.
How Strong Is a Leap Year Cocktail?
Martinis are rarely light drinks and the leap year follows that pattern. This shouldn't come as a surprise because the majority of the cocktail is made of alcoholic ingredients. Though it will vary slightly, this cocktail's alcohol content will be in the 29 percent ABV (58 proof) range.
Recipe Tags:


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NEWARK, Calif., March 17, 2016 (GLOBE NEWSWIRE) -- CymaBay Therapeutics, Inc. (NASDAQ:CBAY) today announced top line results from its pilot Phase 2 clinical study of MBX-8025 in patients with homozygous familial hypercholesterolemia (HoFH). The study demonstrated that the range of responses to MBX-8025 was broad, but that MBX-8025 provided a clinically meaningful reduction in low-density lipoprotein cholesterol (LDL-C) for a subset of patients. This is the first study to demonstrate the potential utility of a PPARδ agonist in HoFH.
"This pilot study provides the first evidence that MBX-8025 has potential utility for the treatment of HoFH, an ultra-orphan disease in which patients remain in need of additional LDL-C lowering," said Harold Van Wart, Chief Executive Officer of CymaBay.
Study objectives and design
This was an open label, dose escalation study of 12 weeks duration conducted at five centers in Europe and Canada. Thirteen patients were enrolled, all of whom had genetically confirmed HoFH, including two subjects who had functionally negative mutations in their LDL receptor (LDL-R) genes. All of the subjects were taking ezetimibe and were on maximum statin therapy. None of the study participants received lomitapide, mipomersen or a PCSK9 inhibitor. Eight patients were undergoing concomitant apheresis on a weekly or biweekly schedule. Despite being on maximal conventional therapy, the average baseline LDL-C was 368 mg/dL. Subjects received once daily treatment with 50 mg of MBX-8025 for 4 weeks, after which the dose was escalated to 100 and 200 mg in successive 4-week periods. The goals of the study were to evaluate the effect on LDL-C as well as a spectrum of other lipid-related parameters, including PCSK9 levels, and to collect safety information.
Two per-protocol analyses were performed on 12 subjects. The data for one subject was excluded because of multiple missed apheresis visits throughout the study which caused marked fluctuations in LDL-C levels. A responder analysis was carried out which reflects the largest decrease in LDL-C observed during treatment for each subject. Three subjects (25%) exhibited a greater than or equal to 30% decrease. Five subjects (42%) had a greater than or equal to 20% decrease, including one patient that was receptor negative, and 7 (58%) had a greater than or equal to 15% decrease. Five subjects (42%) had a less than 15% decrease. The average maximum decrease in the study was 19%. Because of the high baseline LDL-C levels in these individuals, these percentage decreases correspond to significant absolute decreases in LDL-C (mean decrease of 109 mg/dL for the subjects with a greater than or equal to 15% decrease). Although reductions in LDL-C tended to be greater at the higher doses, no clear dose response was observed.
In a second analysis, the mean change in LDL-C for each subject was calculated by averaging values across all doses and dosing periods while on treatment. The overall mean change for all 12 subjects was a decrease of 10%. Eight of these subjects had a mean decrease in LDL-C of 16%, including 3 with a greater than 20% decrease. This included one patient that was receptor negative. This was offset by 4 patients who showed a mean increase of 4%.
Mean PCSK9 was elevated at baseline (544 +/- 133 ng/mL), as anticipated for patients with HoFH, and increased significantly during treatment by a mean of 43%. During the study, decreases in the mean levels of alkaline phosphatase (30%), gamma glutamyl transferase (27%) and total bilirubin (22%), which are markers of cholestasis, were also observed. There were three SAEs, none drug related, and three treatment discontinuations for AEs possibly related to MBX-8025.
"Despite the availability of new therapies, including PCSK9 inhibitors, most patients with HoFH remain far from their LDL-C targets and there is still a need for new therapeutic approaches," said Dr. Evan Stein, Director Emeritus of the Medpace Metabolic and Atherosclerosis Research Center. "The finding that MBX-8025 lowers LDL-C, despite the unexpected increase in PCSK9, suggests that studies on top of PCSK9 inhibitors may be warranted to further assess the potential of MBX-8025 treatment in patients with HoFH."
"We are encouraged by the meaningful response in LDL-C reductions observed in a number of patients in the study and plan to evaluate the feasibility of conducting a pilot study of MBX-8025 in combination with a PCSK9 inhibitor," said Harold Van Wart.
Conference Call
CymaBay will host a conference call today, March 17, 2016, at 4:30 p.m. ET / 1:30 p.m. PT to discuss the results of this pilot Phase 2 study. The call can be accessed by dialing 877-407-0784 (domestic) and 201-689-8560 (international) five minutes prior to the start of the call. A slide presentation to be used in connection with the call entitled "MBX-8025 Pilot Study in HoFH Top Line Data" has been posted on CymaBay's website and can be accessed at http://ir.cymabay.com/presentations. A live audio webcast of the call can be accessed under the Investors section of CymaBay's website at http://ir.cymabay.com/events and will be available for 14 days following the call.
About MBX-8025
MBX-8025 is a potent and selective agonist of PPARδ, a nuclear receptor important for lipid transport, storage and metabolism in liver and muscle. MBX-8025 has shown favorable effects on lipid and other metabolic parameters in a Phase 2 study in patients with mixed dyslipidemia. Treatment effects observed include lowering of LDL-C with selective depletion of pro-atherogenic dense LDL particles, decreases in triglycerides and increases in HDL, as well as decreases in hsCRP, a biomarker of cardiovascular and systemic inflammation. MBX-8025 also decreased levels of alkaline phosphatase and gamma glutamyl transferase, which are markers of cholestasis. The U.S. Food and Drug Administration (FDA) has granted the Company orphan drug designation for MBX-8025 as a treatment for HoFH and Fredrickson types I and V hyperlipoproteinemia. CymaBay has also initiated a Phase 2 study of MBX-8025 in patients with primary biliary cholangitis.
About HoFH
HoFH is a rare, life-threatening, autosomal genetic disease characterized by loss-of-function mutations in both alleles of the LDL receptor (LDL-R) gene. The accompanying loss of LDL-R activity results in marked elevations in the plasma levels of LDL cholesterol (LDL-C), causing premature cardiovascular disease that often presents during the first decades of life and which can result in myocardial infarction, ischemic stroke and premature death.
About CymaBay
CymaBay Therapeutics, Inc. (CBAY) is a clinical-stage biopharmaceutical company developing therapies to treat metabolic diseases with high unmet medical need, including serious rare and orphan disorders. MBX-8025 is a potent, selective, orally active PPARδ agonist. A Phase 2 study of MBX-8025 in patients with mixed dyslipidemia established that it has an anti-atherogenic lipid profile. CymaBay has completed a pilot Phase 2 study of MBX-8025 in patients with homozygous familial hypercholesterolemia and has an ongoing Phase 2 study in patients with primary biliary cholangitis. Arhalofenate, CymaBay's other product candidate, is a potential Urate-Lowering Anti-Flare Therapy that has completed five Phase 2 studies in gout patients. Arhalofenate has been found to reduce painful flares in joints while at the same time promoting excretion of uric acid by the kidney. This dual action addresses both the signs and symptoms of gout while managing the underlying pathophysiology of hyperuricemia.
Cautionary Statements
The statements in this press release, including those statements regarding the structure and conduct of clinical trials, future performance of CymaBay's product candidates, the potential of MBX-8025 to treat homozygous familial hypercholesterolemia or primary biliary cholangitis, the therapeutic and commercial potential of MBX-8025, and any of the targeted indications for the potential future development or commercialization of MBX-8025 are forward looking statements that are subject to risks and uncertainties. Actual results and the timing of events regarding the further development of MBX-8025 could differ materially from those anticipated in such forward-looking statements as a result of risks and uncertainties, which include, without limitation, risks related to: the success, cost and timing of any of CymaBay's product development activities, including clinical trials of MBX-8025; effects observed in trials to date which may not be repeated in the future; any delays or inability to obtain or maintain regulatory approval of CymaBay's product candidates in the United States or worldwide; and the ability of CymaBay to obtain sufficient financing to complete development, regulatory approval and commercialization of its product candidates in the United States and worldwide. Additional risks relating to CymaBay are contained in CymaBay's filings with the Securities and Exchange Commission, including without limitation its most recent Quarterly Report on Form 10-Q and other documents subsequently filed with or furnished to the Securities and Exchange Commission. CymaBay disclaims any obligation to update these forward-looking statements except as required by law.
For additional information about CymaBay visit www.cymabay.com.
Sujal Shah
CymaBay Therapeutics, Inc.
(510) 293-8800
Hans Vitzthum
LifeSci Advisors, LLC


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Most of our senior heroes need glamour and romance in their films unless they decide to go without heroine for a film that really does not have to be one in it. The director's team has to go for a popular actress that suits the role, and not just 'any' heroine will do.
There comes Nayanthara with her conditions, sanctions and their numbers. Nayan does not have qualms about acting opposite 60-plus heroes, in fact, she is avoiding the roles opposite the younger lot. She started to reject those roles pairing younger heroes, so she need not act in romantic and kissing scenes which her boyfriend Vignesh Shivn usually does not encourage her to do.
The scarcity of proper heroines to act with senior heroes is Nayan's asset and she is putting it on optimum advantage. Nayan will be taking some 4 to 5 Cr for each film if it is limited for only one language. If the movie is releasing in multiple languages, the remuneration will be hiked.
Nayanthara will not be part of promotions, no matter what. If the film needs extra call sheets of her, there should be an extra payment and by any mistake, if those call sheets are wasted, she is not going to compensate them.
Sye Raa's team had to cut down her role considering her long list of conditions and regulations, though they paid her huge remuneration. Nayanthara reportedly charged 5 Cr for Darbar where she will not be seen more than 20 minutes. Darbar is no different without Nayanthara's role, but she charged that huge money just to stand next to Rajinikanth. This is Nayanthara's formula to earn crores, effortlessly.
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HARGEISA, 10 February 2011 (IRIN) – More than 3,000 people have been displaced from settlements in Somaliland's eastern region of Toghdeer following a five-hour-long battle on 7 February between the Somaliland National Army and clans loyal to the Sool, Sanag and Cayn (SSC) milita group.
A long-standing dispute exists over the territories of Cayn, Sool and Sanag, with both the self-declared republic of Somailiand, in northwestern Somalia, and the self-declared autonomous region of Puntland in the northeast claiming them. SSC are fighting to remain part of the original state of Somalia.
Abdullahi Yusuf Koreey, an elder from the area, told IRIN that more than 500 families (3,000 people) were displaced from the village of Hagoogane. "Most are pastoralists."
He said the area had been suffering from severe water shortages before the fighting. "Many of the families have gone to areas with little or no water points. If their lives were difficult before it is 10 times worse now," said Koreey.
"We know about 100 families were displaced to Buhotle District from Kalshale, Maygagle and Hagoogane villages [north of Buhotle]," said Faisal Jama, an independent journalist in Las-anod, the main town in the SSC region.
A local journalist told IRIN the fighting was over water and land.
He said many of those displaced were in areas difficult to access. "They are nowhere where aid agencies can access them."
Over 30 killed
Ahmed H Abdillahi Roraye, director-general of the resettlement and refugees department of Somaliland's ministry of interior, told IRIN that another 120 families had been displaced to Burao, capital of the Toghdeer region.
"We are now sending an assessment team to evaluate the number of displaced in the area," he said.
According to journalists in the area, the 7 February clashes killed at least 32 and injured nearly 60 people. Gen Nuh Tani, Somaliland's army chief, told the media the same day that at least four of his soldiers were killed in the conflict.
"According to information we have received from the Somali Red Crescent in Galka'ayo [south-central Somalia], 21 people were taken to hospital, but two of them died on the way," said an official from Somaliland's Red Crescent who requested anonymity.
Another 31 people have been hospitalized in Burao, according to army sources.
Aid workers say continued clashes will increase the suffering of people already dealing with severe drought. "This will make things worse for people who were also suffering the worst drought they have ever experienced," the Somali Red Crescent source said. "And we are worried that if the conflict continues it will be difficult to reach people in the area."


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Dodge Durango Limited Premium Group
The 2014 Dodge Durango. It features all-wheel drive versatility, an automatic transmission, and a refined 6 cylinder engine. It's equipped with tons of terrific amenities, but it won't break your budget. Like heated seats, leather upholstery, adjustable headrests in all seating positions, power front seats, speed sensitive wipers, automatic dimming door mirrors, heated steering wheel, and seat memory. In the event of a rollover collision, side curtain airbags provide additional protection for outboard seated passengers. It also arrives with a Carfax history report, providing you peace of mind with detailed information. We have a skilled and knowledgeable sales staff with many years of experience satisfying our customers needs. We'd be happy to answer any questions that you may have. Stop by our dealership or give us a call for more information.


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Soil pH is generally referred to as potential hydrogen or the hydrogen ion concentration of the soil. It basically is a logarithmic scale determining the acidity of the soil that ranges from 1 to 14 with 7 being the neutral point. A soil found to be at a pH lower than 7 is acidic and higher than 7 is alkaline. Most garden soils pH range in between 5.5 to 8.0, and 6 or 7 is ideal for vegetable plants.
Generally speaking, pH plays a very important role determining whether your plants are healthy or not. Some plants like lilacs and clematis prefer sweeter soil while some others like blueberries like more of an acidic soil. If your plants seem to be growing healthy it means that the soil is maintaining a balanced pH level, but in case your plants are spindly or troubled, try changing the pH of the soil.
Note, pH of the soil determines its nutritional content for an example, an alkaline soil is more likely to have a limited proportion of minerals like phosphorous, iron, and zinc while an acidic soil would be containing less of calcium and magnesium. So considering your plants need maintain the acidity of the soil or its pH level so that you can the right ratios of the minerals in it thereby helping them to thrive well and being healthier. Remember, if the pH of the soil is not maintained properly then the plants will not be able to access the soil nutrients, no matter how much you feed them.
Considering the above, you may now be familiar of the importance of the soil pH levels. So it becomes very important to test the soil for its acidity on regular intervals. Several types of pH testers are available in the market or at the garden center, which you can use to determine your soils acidity or alkalinity. Moreover, if you find it difficult to locate one such tester, just visit your Cooperative Extension office and get your soil tested at a very nominal cost. Once you are aware of your soil pH level, you can accordingly increase or decrease its acidity or alkalinity. You follow simple steps such as adding a bit of lime to raise the pH or adding a form of sulfur to lower it down.
But remember, doing these would not instantly affect your soil's pH. It will take few months for your soil to register the change. So you have to keep on getting it tested periodically until the required results are achieved. In case you find it difficult to cope up with the long waits, change your plants depending on the pH level of the soil.


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SpotXplore is a plug-in for Cytoscape which enhances the visual analysis of gene expression obtained by, e.g., microarrays or the newer RNA-seq techniques in various ways. It enables visualization of multiple conditions or time series by glyphs that encode both expression value and statistical confidence. This visual mapping was introduced in GENeVis, which we have developed as a stand-alone application. SpotXplore can also detect subnetworks of interest based on the expression data, and it provides visualization techniques to explore these subnetworks.
SpotXplore features:
- runs as plug-in for Cytoscape
- improved visualization of time points or multiple conditions
- active subnetwork (hotspot) detection and visualization
M. A. Westenberg, J. B. T. M. Roerdink, O. P. Kuipers, S. A. F. T. van Hijum. SpotXplore: a Cytoscape plugin for visual exploration of hotspot expression in gene regulatory networks. Bioinformatics, 26(22):2922-2923, 2010.
Download and installation
- Download and install Cytoscape [Cytoscape web site].
- Download SpotXplore archive (version 2010/08/04) [zip]. Install by unpacking the archive in the Cytoscape plugins folder. There is only a single Java jar file contained in the archive. Note: some browsers already unpack the archive, but do not rename the resulting file. If the plugin does not show up in Cytoscape's menu, try to rename SpotXplore.zip to SpotXplore.jar, and restart Cytoscape.
- Download an example data set [Cytoscape session file]. Details about the data set are in de user manual.
- Download the user manual [pdf].
Quick start: Run Cytoscape, load the session bsubtsession.cys, and invoke SpotXplore from the Plugins menu.
Time series visualization
Hotspot detection and visualization
SpotXplore supports a number of ways to find or define hotspots of gene expression:
- GiGA: automatic detection by graph-based iterative group analysis, see Breitling et al. (2004).
- Luscombe: trace-back algorithm by Luscombe et al. (2004) to identify subnetworks that are active.
- Manual: converts a selection set in Cytoscape to a hotspot. It is possible to construct multiple hotspots per time point or condition.
[Play an animation of the time series].
The short 'movie of life' makes apparent that the impact of the ccpA mutation dynamically develops and intensifies during growth of B. subtilis cells. At the last time point, one hotspot is detected which overlaps almost completely with the SigB regulon. This regulon is involved in the response to harmful environmental conditions, such as heat, osmotic, acid, or alkaline shock. This hotspot is interesting, since it explicitly reveals that the SigB regulon is recruited stronger during the late growth stages of the wild-type strain than the ccpA deletion strain. Additional data might be required to provide a biological explanation for this effect.


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MyABCM solution is an integrated package, intuitively managing Activity Based Costing and helping companies to manage their costs, to assign these costs to the right internal or external target and to understand to the smallest details all present and future investment impacts, without any development, simply via effective dashboarding. Asfalys has the exclusivity to distribute MyABCM and proposes professional services to implement the solution in Belgium and Luxemburg.
MyABCM – Cost and Profit Management Software
Easy to use, flexible and quick to install.
Companies undoubtedly know how much the total costs are, the total revenue and total profit, but do they know their best and worst product, service, customer or channel is in terms of profitability?
To be competitive in the current economic climate, companies need accurate data that enables them to make reliable strategic and operational decisions. Relying on this information allows executives to implement profit maximization strategies and giving them a significant competitive advantage in their market.
MyABCM unveils the costs of each activity, product or customer. Collecting, modeling, analyzing and simulating; MyABCM offers tailor-made solutions for managing costs and profitability, and for controlling expenses.
MyABCm helps companies take the first steps to integrate the solution with existing systems, generate advanced reports and analysis and prepare companies to easily perform complex business simulations. Even in complex cost model environments, with full autonomy. MyABCM is a user-friendly tool, flexible and quick to install.
Established worldwide, MyABCM is present in 12 countries on five continents. In France, Europe and all Francophone countries, MyABCM is distributed exclusively by ABCosting France. Asfalys is the exclusive partner of ABCosting France for the distribution and implementation of the MyABCM solution in Belgium and the Grand Duchy of Luxembourg.
- Trace costs (that are not always visible): from a final Product or Service, trace back all the direct and indirect costs that have been assigned to it from various accounts; on the other side, determine the impact of providing these Products or Services to different Clients/distribution channels knowing the exact cost of these products or services.
- Re-invoice to internal or external customers knowing all the costs components of the Products or Services (invoice easy to explain)
Make simulations easily about the future
Spend less timecollecting information and making calculations on spreadsheets and more making strategic decisions. Conduct advanced analyses and simulations and identify bottlenecks.
Make accurate and well-informed business decisionsbased on exhaustive cost components set
Easy to install and to customize(step by step implementation) with quick wins.
Recognized by its customers as the fastest solutionon the market to implement
MyABCM in numbers
Countries where MyABCM is present
Centers of excellence around the world
Years of experience in the most varied types of projects
Customers worldwide
You don't have to restrict your analyses to Resources, Activities and Cost Objects; you can construct a model with an unlimited number of dimensions which will help you in terms of decision making in more heterogeneous and complex modeling environments.
Construct and analyze the same model simultaneously with your counterparts located in other countries who speak different languages without having to replicate the database – thereby consolidating information and gaining efficiency.
Connect MyABCM data to Corporate BI. Access the data from the model you've developed through any external tool such as Tableau, Qlik, PowerBI, MicroStrategy, Cognos and others.


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Overview of Mauritius
General Information
Mauritius, an island covering 1,860 square kilometres (720 square miles), is situated some 2,000 kilometres (1242 miles) off the south East coast of Africa. More than 150 kilometres (93 miles) of white sandy beaches and transparent lagoon are protected from the open sea by the world's third largest coral reef, which surrounds the island.
The population is estimated at 1,2 million. It forms a mosaic of different races, cultures and religions since Mauritians are descendants of immigrants from the Indian sub-continent, Africa, Europe and China. The cultural diversity and racial harmony of the island make of Mauritius a unique place. Most Mauritians are multilingual, being fluent in Creole, French and English. English is the official language. Bhojpuri, Hindi, Urdu, Tamil, Marathi, Telugu and Mandarin are also spoken.
Mauritius is a democracy modelled on the British system of parliamentary democracy, which guarantees the separation of legislative, executive and judicial powers. The President is the Head of State and Commander-in-chief while the Prime Minister has full executive powers and is the Head of Government. Sixty-two members of the National Assembly are elected every five years by universal adult suffrage. Democracy is well entrenched in Mauritius and all major political parties are represented in Parliament.
Location: Southwest of the Indian Ocean, 2,000 km off East Africa, between Latitudes 19°50 and 20°32South and Longitudes 57°18 and 57°46 East
Surface Area : 1,860 sq km
Climate: Maritime climate tropical summer (27°C - 33°C)subtropical winter (17°C - 25°C)Central plateau rises 600 metres above sea-level.
Highest mountain peak: Piton de la Rivière Noire
The island had for a long time remained unknown and uninhabited. Arab sailors reportedly visited it during the Middle Ages, and on maps of about 1500, it is shown by an Arabic name 'Dina Arabi'. The Portuguese sailor Domingo Fernandez Pereira was the first European to land on the island around 1507. The island appears with a Portuguese name `Cirne' on early Portuguese maps, probably because of the presence of the Dodo, a flightless bird found in great numbers at that time.
It was another Portuguese sailor, Don Pedro Mascarenhas, who gave the name Mascarenes to the group of islands now known as Mauritius, Rodrigues and Réunion. The Portuguese did not settle permanently on these islands.
The Dutch period (1598-1710)
The French period (1715-1810)
The British period (1810-1968)
Constitutional development
In 1598, a Dutch squadron, under the orders of Admiral Wybrand Van Warwyck, landed at Grand Port and named the island Mauritius, in honour of Prince Maurice Van Nassau, "Stathouder" of Holland.
However, it was not until 1638 that a first attempt was made at Dutch settlement. It was from here that the famous Dutch navigator Tasman set out to discover the Western part of Australia. The Dutch are remembered for the introduction of sugarcane, domestic animals and deer. They left Mauritius in 1710.
After the Portuguese and the Dutch, the French took an interest in Mauritius. By 1715, they had started to settle on a permanent basis on the island which they renamed Isle de France. French governor François Mahé de La Bourdonnais established Port Louis as a naval base and a shipbuilding centre. Under his governorship, numerous buildings were put up, a number of which are still standing to-day - part of Government House, the Château de Mon Plaisir at Pamplemousses and the Line Barracks The island was under the administration of the French East India Company which maintained its presence until 1767.
From that year until 1810, it was in charge of officials appointed by the French Government, except for a brief period during the French Revolution, when the inhabitants set up a government virtually independent of France.
During the Napoleonic wars, Isle de France had become a base from which French corsairs organised raids on British commercial ships. The raids continued until 1810 when a strong British expedition was sent to capture the island. A preliminary British attack was foiled at Grand Port in August 1810 but the expedition launched in December of the same year from Rodrigues, which had been captured a year earlier, was successful. The British landed in large numbers in the North of the island and rapidly overpowered the French, who capitulated. By the Treaty of Paris in 1814, Isle de France which regained its former name of `Mauritius' was ceded definitely to Great Britain, together with its dependencies which included Rodrigues and the Seychelles. In the Act of Capitulation, the British guaranteed that they would respect the language, the customs, the laws and the traditions of the French settlers.
The British administration, which began with Robert Farquhar as Governor, was marked by rapid social and economic changes. One of the most important events was the abolition of slavery in 1835. The planters received a compensation for the loss of their slaves who had been brought in from Africa and Madagascar during the French occupation.
The abolition of slavery had important repercussions on the socio-economic and demographic fields. The planters turned to India, from where they brought a large number of indentured labourers to work in the sugar cane fields. The Indian immigrants, who were of both Hindu and Muslim faiths, were to change rapidly the fabric of the society. They were later joined by a small number of Chinese traders.
Cultivation of sugar cane was given a boost and the island flourished, especially with the export of sugar to England. Economic progress necessitated the extension and improvement of communications and infrastructure.
On the Constitutional plane, the Council of Government which was first established in 1825, was enlarged in 1886 to make room for elected representatives. The new Council included 10 members elected on a restricted franchise. It was not until 1933 that the Constitution was significantly amended. The proportion of nominated members of the Council not holding public office was raised to two-thirds. However, franchise was still restricted to persons within a certain income bracket and to property owners. A major breakthrough occurred in 1948, when after years of protracted negotiations for a more liberal Constitution, franchise was extended to all adults who could pass a simple literacy test.
The Council of Government was replaced by a Legislative Council composed of 19 elected members, 12 members nominated by the Governor and three ex-officio members. General elections were held in August 1948 and the first Legislative Council met on 1st September 1948.
Following Constitutional conferences held in London in 1955 and 1957, the ministerial system was introduced and general elections were held on 9th March 1959. Voting took place for the first time on the basis of universal adult suffrage and the number of electors rose to 208,684. In 1961, a Constitutional Review Conference was held in London and a programme of further Constitutional advance was established. It was followed in 1965 by the last Constitutional Conference which paved the way for Mauritius to achieve independence. After general elections in 1967, Mauritius adopted a new Constitution and independence was proclaimed on 12 March 1968 under the leadership of Sir Seewoosagur Ramgoolam, the first Prime Minister of Mauritius. The island achieved the status of Republic 24 years later on 12 March 1992.
The various population movements of the 18th, 19th and early 20th centuries have made Mauritius a unique blend of different races, cultures and religions. People of European, African, Indian and Chinese origins have created a multiracial society where the various cultures and traditions flourish in peace and harmony.
The population started to grow under French rule in the 18th century. In 1735, the population was estimated at a thousand and reached nearly 20,000 in 1767, 15 000 of them being slaves. When the British abolished slavery in 1835, the population stood at 100,000. The population increased rapidly with the influx of Indian labourers. Between 1835 and 1865, some 200,000 labourers were brought in. By the turn of the century, the population numbered 371,000 and in 1944 it stood at 419,000. After the Second World War, the increase was more rapid as a result of the eradication of malaria and other diseases.
The rate of birth which was about 3 per cent in the 1960's has considerably dropped with family planning campaigns and greater awareness due to better education. During the last ten years, the population has grown at an average rate of 1.1 per cent annually. At the end of September 2002, the population of the Republic of Mauritius was estimated at 1,210,000.
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Release Notes 2018-02-08
Fixed Bugs
- After switching to a new communication tool, the evaluation approval and a couple of other features stopped working correctly. We rolled back to a previous communication tool.
- Fixed an issue with the addition of an existing user as collaborator
- Hid "Delete Account" tab for everyone except account owner
- Fixed an issue with multiple redirects on logins
- Fixed an URL where a user was redirected after connecting a social network
- Fixed an issue with the addition of an existing user as trainer
- Fixed filters on the list of attendees for trainers
- Fixed an issue with Twitter login when a user bumped into a "Not Found" page


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A ruling was made by a federal judge yesterday regarding the future of red wolves in North Carolina. You can read the full text of the court's ruling here.Read More
The North Carolina Wildlife Federation has announced the winners of the 55th Annual Governor's Conservation Achievement Awards. This year's winners are exceedingly notable conservation devotees who work for wildlife, habitat, and those who cherish natural resources. They are land stewardship champions, water advocates, and leaders in the preservation of unique ecosystems. The award winners include…Read More
Summer is here and so are some new and exciting programs at Pocosin Lakes National Wildlife Refuge! Do you want to learn more about red wolves, black bears, or waterfowl? Would you like the chance to see a live red wolf up close? Have you ever wondered, "What is a Pocosin anyways?" Join NCWF's Refuge…Read More
The North Carolina Wildlife Federation is seeking nominations for the Governor's Conservation Achievement Awards – the state's highest honors given to conservation leaders who take an active role in protecting North Carolina's natural resources. Since 1958, the awards have honored individuals, associations, businesses and governmental bodies that have exhibited an unwavering commitment to conservation in…Read More
Students committed to environmental and natural resource conservation and management can now apply for a 2018 North Carolina Wildlife Federation scholarship. The Federation will provide up to 7 grants to students – graduate students and undergraduate students are eligible – awarded as seven $1000 grants, or six $1000 grants and one $2,500 Conservation Leadership grant,…Read More
Recovering America's Wildlife Act: Conservation funding for more than 12,000 species of concern. A letter of support has been hand-delivered to the NC Congressional delegation. Click here to view the letter and full list of supporters.Read More
The NCWF Board of Directors has adopted two resolutions that will protect our North Carolina marine ecosystems and wildlife. Read the full resolutions here: Resolution on North Carolina Marine Habitat Protection Resolution on North Carolina Marine Fisheries ReformRead More
The N.C. Wildlife Resources Commission and the N.C. Wildlife Federation are offering four free deer hunting and processing seminars in Raleigh and Fayetteville in September. The "Introduction to Deer Hunting" and the "Practical Deer Processing: From Field to Freezer" seminars are ideal for novice hunters, although hunters and their mentees are encouraged to attend. Topics…Read More
The North Carolina Wildlife Federation has announced the winners of the 54th Annual Governor's Conservation Achievement Awards. The full list of award winners and categories is below. This year's winners are exceedingly notable conservation devotees who work for wildlife from elk to amphibians to fish and marine resources. They are water quality advocates, land stewardship…Read More
More than 35 North Carolina hunting, fishing and outdoor groups have sent a letter to Congressional members of the state delegation calling for a strong defense of America's public lands and efforts to oppose any legislative attempts to sell or transfer lands out of the public domain. This letter comes on the heels of the…Read More
Support the North Carolina Wildlife Federation
Gather your family and friends and plan your next outdoor adventure for one of North Carolina's many unforgettable natural destinations. Help NCWF preserve wildlife and wild places for our children and future generations to come.