text:
Kyle J. Norton
The widespread of prostate cancer, once considered a disease of aging
male, now have become major concerns of governments and scientific
community in South East Asian with tendency to effect even younger age
population. Suggestions emerged of over consuming bad fats in any time
in history accompanied with unhealthy diet and life style may be the
possible causes of the disease, linking to the economic prosperity over 2
decades. Foods for diseases' management have been prescribed in folk
medicine over thousands of year as one of best medicine of nature in
preventing and treating diseases, including prostate cancer.
Prostate cancer is defined as a condition in which the cells of
prostate has become cancerous, causing abnormal cell growth with
possibility of spreading to the distant parts of the body. Most
prostate cancers are slow growing and enlarged prostate and prostate
cancer may be detected during physical (rectum) exams.
A. Types of vegetables may reduce risk of Prostate cancer
1. Cruciferous vegetables
Cruciferous vegetables are the group of vegetables belonging to the
family Brassicaceae, including cauliflower, cabbage, cress, bok choy,
broccoli etc..
Epidemiological studies has demonstrated reduced risk of prostate cancer in cruciferous consumption. Indole-3-carbinol, a major chemical compound in Crucifers, are found to be effective in inhibiting prostate cancer by blocking initiation through induction of phases I and II detoxification pathways and suppressing prostate cancer
progression, through down-regulated cell signaling pathways(1). Its
derivative 3,3'-Diindolylmethane (DIM), showed to activate the
AMPK(regulator of cellular energy homeostasis) signaling pathway,
associated with suppression of the mammalian target of rapamycin
(mTOR)(cell regulator), down-regulation of androgen receptor (AR)
expression, and induction of apoptosis in both androgen-sensitive prostate cancer
cells(2). Erucin (ER), derived from Isothiocyanates (ITCs) in
crucifers, may hold an anti progressive property in prostate cancer as
it showed an effect in increasing significantly p21 protein expression (
regulator of cell cycle progression at G1 and S phase) and
ERK1/2 phosphorylation(cell regulation) in a dose-dependent manner to
inhibit PC3(Human prostate cell line) cell proliferation(3).
Sulforaphane (SFN) in crucifers also inhibited prostate cancer cell
line through impacting epigenetic pathways(4).
2. Tomato
Tomato is a red, edible fruit, genus Solanum,
belonging to family Solanaceae, native to South America. Because of its
health benefits, tomato is grown world wide for commercial purpose and
often in green house.
Studies of tomato, linking to reduced risk of prostate caner have produced inconsistent results.(5)(6)(7)(8)(9). Regardless to these mixed results, intake of lycopene and specific tomato products acknowledged by many researchers is associated in reduced risk prostate cancer. Lycopene, a lipid soluble carotenoid molecule found in tomato and Alpha (α)-tomatine, a saponin presented in tomato, showed to exert its tumor
suppressing effects by increased apoptosis and lower proliferation of
tumor cells.(10)(11). According to the Northwestern University Medical
School, in a recent prospective dietary analysis identified lycopene as
the carotenoid with the clearest inverse relation to the development of prostate cancer(12)(13). In Androgen-independent DU145 prostate cancer
cells, Apo-lycopenals or other lycopene metabolites, significantly
reduced cell proliferation through alteration of the normal cell
cycle(14). In BALB/c nude mice, lycopene caused DU145 cells to
accumulate in the G(0)/G(1) (Cell cycle)phase and to undergo apoptosis
in a dose-dependent manner(15).
3. Garlic
Garlic is a natural
superfood healer for its natural antibiotic with antiviral,
antifungal, anticoagulant and antiseptic properties.
Garlics intake, are related to decreased risk of prostate cancer(17), in a reviewed study with evidence from 132,192 subjects(18). S-allylcysteine (SAC) derived from garlic,
suppressed the proliferation of PC-3 cells and led to cell cycle arrest
at the G0/G1 Cell cycle)phases, as well as inducing cell apoptosis
which was accompanied by the decreased expression of Bcl-2 and increased
expression of Bax and caspase 8(19). Diallyl disulfide (DADS) another
compound in garlic, at 25 and 40 microM concentrations induced cell
cycle arrest and apoptosis in PC-3 cells through increased expression
of caspases(extent of apoptosis)(20) (3, 9, and 10), proapoptotic protein Bax(Apoptosis regulator)(21).
4. Sweet potato
potato is a large, starchy, sweet tasting tuberous roots vegetable,
genus Ipomoea, belonging to the family Convolvulaceae. Its young leaves
can be made into a delicious dish in Chinese foods but some species of
batatas are actually poisonous.
Sweet potato (Ipomoea batatas) leaves, a favor vegetable consumed
extensively in Africa and Asia, containing rich sources of dietary
polyphenols (anthocyanins and phenolic acids) exerted its significant
antiproliferative activity in some prostate cancer cell lines without damaging to normal prostate
epithelial cells. SPGE (Sweet potato extract) altered cell cycle
progression, reduced clonogenic survival, modulated cell cycle and
apoptosis regulatory molecules and induced apoptosis in human prostate cancer PC-3 cells both in vitro and in vivo(22). In nude mice testing, the extract inhibited growth and progression of prostate tumor xenografts by ~75%(23).
5. Ginger
Ginger (Zingiber
officinale) or ginger root is the genus Zingiber, belonging to the
family Zingiberaceae, native to Tamil. It has been used in traditional
and Chinese medicine to treat dyspepsia, gastroparesis, constipation,
edema, difficult urination, colic, etc.
Ginger extract (GE) and 6-gingerol. a chemical constituent found in
ginger root, synergistically inhibited proliferation of PC-3 cells(24).
Daily oral feeding of 100 mg/kg body weight of GE, inhibited growth and
progression of PC-3 xenografts by approximately 56 % in nude mice and
reduced proliferation index and widespread apoptosis compared with
controls(25). In the comparison of GE and an artificial quasi-mixture
(Mix) formulated by combining four most-active ginger constituents at concentrations equivalent, GE showed 2.4-fold higher tumor growth-inhibitory efficacy than Mix in human prostate tumor xenografts(26).
6. Spinach
Suggestion of intake of typical green and yellowvegetable and spinach were associated to reduced risk factors for prostate cancer(27) and risk of aggressive prostate cancer decreased with increasing spinach consumption(28). Spinach extract (NAO) exerted its anti profileration of the human
PCA cell line PC3 by NAO-induced G1 delay and prolonged cell cycle prolongation as a result of
downregulation of the protein expression of ppRb(tumour suppressor pathway)(29)and E2F transcription factors(30). In human prostatic cancer
(PCA) cell lines DU145 and PC3, showed an inhibition of cellular
proliferation occurred in a dose-dependent manner, increasing numbers of
G1 cells (Cell cycle)and reducing ROS(reactive oxygen species)
7. Chili pepper
Chili pepper is
the fruit of plants from the genus Capsicum, belonging to the
nightshade family, Solanaceae. The fruit has been used in human history
for spices and cultivated for commercial profits.
Capsaicin, a chemical constituent of chili pepper exerted its antiproliferative activity correlates with oxidative stress induction and apoptosis and potently suppresses the growth of human prostate
carcinoma cells in vitro and in vivo(32), inducing the apoptosis of
both androgen receptor (AR)-positive (LNCaP) and -negative (PC-3,
DU-145) prostate cancer cell lines
associated with an increase of p53, p21, and Bax(33)(34). Capsaicin in
other study showed to induce apoptosis in PC-3 cells(Prostate cancer)
via ROS(reactive oxygen species) generation, JNK(tumorigenetic
regulator) activation, ceramide accumulation, and second, extracellular
signal-regulated protein kinase (ERK) activation(35).
8. Carrot
Studies of Dietary intake of the carotenoids beta-carotene and lycopene
found in carrot for its reduced risk of prostate cancer has produced
inconsistent results. Some studies suggested that dietary intake of
beta-carotene and its main vegetable sources was largely unassociated
with prostate cancer risk, whereas intake
of lycopene and tomato-based foods was weakly associated with a reduced
risk(36). In antioxidant study, some researchers suggested that beta-carotene supplementation in men with low dietary beta-carotene intakes were associated with reduced risk of prostate cancer(37) and vegetable and carotene intake was associated with lower risk of prostate cancer among Japanese(38). Unfortunately, there is a report of intake of beta-carotene supplement may increase prostate cancer
incidence, 23% higher and mortality, 15%
higher in comparison with those not receiving(39).
9. Mushroom
is a standard name of white button mushroom, the fleshy, spore-bearing
fruiting body of a fungus produced above ground on soil or on its food
source, It is a genus A. Muscaria, belonging to the family Amanitaceae and has been cultivation in many cultures all over the world for foods and health benefits.
Mushroom Inonotus obliquus (I. obliquus) petroleum ether and ethyl acetate fractions was found effectively against human prostate cancer cell line PC3 by inhibition effects on NO production and
NF-κB luciferase activity in cells produced by the differentiation of white blood cells in RAW 264.7 cells and cytotoxicity(40). Also in human androgen-independent cancer PC-3 cells, water-soluble extract (POE) of the fresh oyster mushroom exerted most significant
cytotoxicity on PC-3 cells comparisin to 2 other mushroom species with
cytotoxicity and induced apoptosis mediated in dose-dependent
manner(41). Polysaccharide-K® (PSK), an extract of the mushroom, induced
significantly tumor suppression in a reduction of tumor proliferation
and apoptosis enhanced, by lowering the decrease in number of white
blood cells, accompanied by increased numbers of
tumor-infiltrating CD4+ and CD8+ T cells.(42).
10. Bean sprouts
eaten raw or cooked, bean sprouts are common ingredient in Asian cuisine, made from sprouting beans.
Isoliquiritigenin isolated from bean sprout, used in treatment on the
migration, invasion and adhesion characteristics of DU145 human prostate cancer showed to inhibit basal and EGF-induced cell(proliferation) migration, invasion in doses dependent(43) and cell proliferation and induced apoptosis in DU145 human prostate cancer cells and MAT-LyLu (MLL) rat prostate cancer
cells, through inhibition of ErbB3 signaling and the PI3K/Akt
((anti-apoptosis and increased cell proliferation)pathway(44). Other
researchers also suggested that these inhibition are associated with an
evident disruption of the mitochondrial membrane potential, and the
release of cytochrome c and Smac/Diablo(a mitochondrial protein), and
the activation of caspase-9(apoptosis)(45).
B. Types of fruit may reduce risk of prostate cancer
1. Mangosteen fruit
Mangosteen fruit, a tropical fruit growth in South East Asia is a tropical evergreen tree originated in the Sunda Islands and the Moluccas of Indonesia.
In 22Rv1 and LNCaP, and prostate epithelial cells (PrECs), standardized mangosteen fruit
extract (MFE), showed its inhibited effect by suppressing tumor growth
in a xenograft tumor model without causing damage to non-tumorigenic prostate
epithelial cell and induced toxicity(46). Polyphenols, the main
chemical constituent of the fruit extract also targeted multiple
signaling pathways involved in cell cycle modulation and apoptosis in
prostate cancer(47). α-Mangostin, a xanthone derived
from Polyphenols of mangosteen fruit, targeted cell cycle-related proteins involved in prostate carcinogenesis(48).
2. Long Pepper or Indian long pepper
Used as a spice and seasoning, Long Pepper or Indian long pepper is a flowering vine in the family Piperaceae.
Piperlongumine (PL), a natural alkaloid presented in the fruit of the Long pepper,
exerted its effect on prostate cancer by downregulation of Akt
downstream signaling(apoptosis, cell proliferation) resulted in decrease
of mTORC1 (nutrient/energy)activity and autophagy (cell
degradation)stimulation(49). PL also found to induce rapid depletion of
the Androgen receptor (AR) in prostate cancer (PC) cells which is an early indication of prostate cancer(50). In human prostate cancer DU145, PC-3 and LNCaP cells, piperine, another an alkaloid from black and long peppers, exhibited anti-proliferative effect in human prostate cancer cells by inducing cell cycle arrest and autophagy(51).
3. Pomegranate
Pomegranates is a fruit-bearing small tree, genus Punica,
belonging to family Lythraceae, native to Iran but has been cultivated
in Asian since ancient time.
POMx, a omegranate (PE) formula currently approved for clinical trials,
effectively inhibited survivin (baculoviral inhibitor), induced
apoptosis, retarded the rate of tumor growth in skeleton(52).
Polyphenols, main chemical compounds from pomegranate
fruit extracts (PFEs), slightly decreased secretion of matrix
metalloproteinase (MMP)-2 but not MMP-9 (expression usually seen in
invasive and highly tumorigenic cancers) from both prostate cell
lines(53). Other polyphenol derivative, ellagic acid (EA) than to
urolithin (UA) converted from Ellagitannins (ETs) from pomegranate juice (PJ), sgnificantly decreased cell proliferation by exhibiting synergism in PC-3 cells(54).
4. Strawberry
Strawberries is a genius of Fragaria × ananassa belongs to the family
Roseaceae. They have been grown all over the world with suitable
climate for commercial profits and for health benefits.
Berry juice study, including strawberry, showed to inhibit prostate
cancer cell proliferation, not involve caspase-dependent apoptosis,
but in cell-cycle arrest, by down-regulation of the expression of cdk4,
cdk6, cyclin D1 and cyclin D3(Decrease the proliferative activity (55).
In fact major classes of berry phenolics, including anthocyanins,
flavonols, flavanols, ellagitannins, gallotannins, proanthocyanidins,
and phenolic acids are found to be effective in inhibition the growth
of many human cancer cell lines, including prostate
(LNCaP) tumor cell lines at concentrations ranging from 25 to 200 micro
g/mL.(56). Crude extracts (250 microg/mL) from strawberry and its
pure compounds (100 microg/mL)also found to inhibit prostate (LNCaP, DU145) cancer cells(57).
5. Grapes
Grape is a woody vines of the genus Vitis, belong to the family Vitaceae, native to southern Turkey.
Fisetin, a chemical compound found in grape inhibited prostate cancer
cell lines through downregulation of the PI3K/Akt (anti-apoptosis and
increased cell proliferation)and the mTOR(energy sources) pathways(58).
Another chemical constituent pterostilbene, in dose-dependent inhibited
cellular proliferation, through activation of expression of
AMPK(cellular energy homeostasis) and the p53(antigens) but in p53
positive LNCaP cells, pterostilbene blocked the progression of cell
cycle at G1 phase by inducing p53 expression and further up-regulating
p21 expression and in p53 negative, induced apoptosis in PC3 cells(59).
Piceatannol found in grape, exhibited potential anticancer
properties by suppressing proliferation of a wide variety of tumor
cells, through cell-cycle arrest, upregulation of antibody antigens and
apoptotic activity and down-regulation of cancer cell
6. Apple
Apple is the pomaceous fruit of
the apple tree, a species of the rose family Rosaceae. It is one of the
most widely cultivated tree fruits. The tree is originated in Central
Apple peel extract (APE), exerted its
anti cancer effects by significant decreasing in growth and enhancing
clonogenic survival of human prostate carcinoma CWR22Rnu1 and DU145 cells, through a G0-G1(Cell cycle) phase arrest(61). In the study of Does an apple a day keep the oncologist away? showed an inverse association of apple intake and incidence of cancer(62).
7. Papaya
Papaya is a species of Carica Papaya, belongs to the family Caricaceae
and native to the tropics of the Americas, and was first cultivated in
Mexico and several centuries.
Benzylisothiocyanate (BITC), a solvent of papaya
fruit inhibited cancer cell line through induced apoptosis by
converging two major pathways: the death receptor mediated extrinsic and
the mitochondrial intrinsic pathway(63). In the role of diet, papaya is
found effectively (more than 22.7 g/d (50th percentile) in reduced prostate cancer
risk by 7.4 (Adjusted OR 7.4 (95% CI 1.17-46.8)(64). Lycopene, a major
chemical constituent in tomato, also in papaya, in prospective and
retrospective epidemiological studies indicated of an inverse
relationship between lycopene intake and prostate cancer risk in vitro and in vivo experiments(65).
8. Apricot
Apricot tree is about 8–12 m tall and a trunk up to 40 cm diameter
belonging to the family Rosaceae. Apricot is classified with the family
of the plum and has yellow to orange, often tinged red on the side
which is exposed to the sun.
Ethanolic extracts (30%) of apricot showed to inhibit the growth of
PC-3 and LNCaP (Prostate cancer cell lines) cells; induce apoptosis and
alter cell kinetics; down regulated ERalpha (estrogen receptor α), ) and
PKC-alpha(interaction with the cell membrane) protein, and demonstrate
good binding ability to both mouse uterine estrogen receptors and LNCaP
human androgen receptors(66).
9. Avocado
Avocados are a commercially
valuable fruit and are cultivated in tropical climates throughout the
world, it is a green-skinned, pear-shaped fruit that ripens after
harvesting and native to the Caribbean, Mexico, South America.
Whole-blood fatty acids testing indicated that higher intakes of dietary
MUFA(monounsaturated fatty) with principal source of dietary avocado intake was inversely related to prostate cancer(67).
Acetone extract of avocado,
containing carotenoids and tocopherols showed to inhibit the growth of
both androgen-dependent (LNCaP) and androgen-independent (PC-3) prostate cancer cell lines in vitro. Incubation of PC-3 cells with the avocado extract led to G(2)/M cell cycle arrest accompanied by an increase in p27(cell cycle inhibitor) protein expression(68).
10. Citrus fruits
Fruits of the genus Citrus, native to southern and southeast Asia, include grapefruit, lemon, orange, etc.
Study of incidence of prostate caner in North India compared to South India, showed a positive decreased risk of increasing dietary consumption of tea, citrus fruits and melon(69). Citrus consumption is associated with reduced all-cancer incidences, according to the study of cancer
incidence among 42,470 Japanese adults in the Ohsaki National Health
Insurance Cohort(70). Oral administration of Gold Lotion (GL), an
extract of multiple varieties of citrus
peels containing abundant flavonoid, showed the deduction of both the
weights (57%-100% inhibition) and volumes (78%-94% inhibition) of the
tumors without any adverse toxicity, accompanied by mechanistic
down-regulation of the protein levels of
inflammatory enzymes (inducible nitric oxide synthase, iNOS and
cyclooxygenase-2, COX-2), metastasis (matrix metallopeptidase-2, MMP-2
and MMP-9), angiogenesis (vascular endothelial growth factor, VEGF), and
proliferative molecules, as well as by the induction of apoptosis in prostate tumors(71). Unfortunately, some studies did not show an association between intake of citrus fruits and the risk of prostate cancer(72).
11. Bitter melon
Bitter melon, a extremely bitter fruit, is a tropical and subtropical vine belonging to the family Cucurbitaceae, native in Asia, Africa, and the Caribbean. Treatment of bitter melon extract (BME) in prostate cancer, enhanced Bax expression(involved in p53-mediated apoptosis) and induced PARP(a nuclear protein implicated in DNA repair) cleavage(during apoptosis), delayed the progression to high-grade prostatic
intraepithelial neoplasia (precede the development of prostate
adenocarcinoma) and displayed approximately 51% reduction of
proliferating cell nuclear antigen expression in mice(73). MCP30, from
bitter melon seeds induced apoptosis in PIN and PCa cell lines
in vitro and suppressed PC-3 growth in vivo with no effect on normal prostate
cells(74). Bitter melon leaf extract (BMLE) inhibited the secretion of
MMP-2, MMP-9(metastasis) and urokinase plasminogen activator
(uPA)(invasion and metastasis) from rat prostate cancer cell line (PLS10)(75).
C. Others
1. Flaxseed
Flax seed is native to the region
of the eastern Mediterranean to India and also known as common flax or
linseed. Flax is an erect annual plant, it can grow to 1.2 m tall. The
leaves are 20–40 mm long and 3 mm broad.
Enterolactone and enterodiol, mammalian lignans derived from dietary flaxseed may obstruct or delay the progressed prostate cancer
cell proliferation via vascular endothelial growth
factor(VEGF)-associated pathways(76). Other study indicated that diet
supplemented with 5% flaxseed inhibits the growth and development of prostate cancer in the TRAMP model(77) and Flaxseed-supplemented
diet showed to lower prostate cancer proliferation rates and associated
with biological alterations that may be protective for prostate cancer(78).
2. Vegetable oil
Vegetables oil is a triglyceride extracted from a plant.
Increased levels of MUFA-rich vegetable oil((including olive oil, canola or peanut oil)) intake were associated with a progressive reduction in prostate cancer risk(79). Hydrogenated soybean oil (SHSO) showed remarkably strong anticarcinogenic activity against prostate cancer in the rat model and 5% dietary supplementation with SHSO inhibited the growth of prostate cancer by 80% in vivo(80).
3. Honey
The rich golden liquid is the
miraculous product made by bees using nectar from flowers. It is
considered as one of healthy sweet food for replacing the use of white
sugar and artificial sweetener by many people.
Chrysin, a natural flavone commonly found in honey, and honey itself showed to exert its antiproliferative effect on PC-3 cells in a dose- and time-dependent manner(81)
4. Chickpea
Garbanzo beans also known as chickpea is an edible legume of genus Cicer
and the family Fabaceae, high in protein and minerals. It is one of the
earliest cultivated vegetables, native to Middle East.
7 protease inhibitor concentrates (PICs) isolated from chickpea showed a significant inhibition the LNCaP prostate cancer cells in concentrations tested of 25-400 μg/ml(82).
5. Olive oil
Extra virgin olive oil (EVOO), was found
to significantly affect the growth of HCT 116 tumours xenografted in
athymic mice(83). Polyphenols, found in Extra virgin olive oil
(EVOO), exerted chemopreventive effects towards different organ
specific cancers,
affecting the overall process of carcinogenesis by
inhibition of DNA synthesis, modulation of ROS production, regulation of
cell cycle arrest, modulation of survival/proliferation pathways(84).
Other study suggested that Polyphenols can directly interact with
specific steps and/or proteins
regulating the apoptotic process in different ways depending on their
concentration, the cell system, the type or stage of the pathological
6. Black pepper
Black pepper, is a flowering vine in the family Piperaceae, its fruits used as a spice and
Piperine, a major alkaloid constituent of black pepper, inhibited the proliferation of LNCaP, PC-3, 22RV1 and DU-145 prostate cancer
cells in a dose dependent manner and induced apoptosis resulted in
caspase activation in LNCaP and PC-3 cells(86). β-caryophyllene oxide
(CPO), a sesquiterpene isolated from essential oils of medicinal plants
such as
guava (Psidium guajava), oregano (Origanum vulgare L.), cinnamon
(Cinnamomum spp.) clove (Eugenia caryophyllata), and black pepper
(Piper nigrum L.) not only inhibited the constitutive activation of
PI3K/AKT/mTOR/S6K1 (anti-apoptosis and increased cell proliferation and
nutrient–hormonal signaling network) pathway
signaling cascade but also down-regulated the expression of various
downstream gene products
that mediate cell proliferation (cyclin D1), survival (bcl-2, bcl-xL,
survivin, IAP-1, and IAP-2), metastasis (COX-2), angiogenesis (VEGF),
and increased the expression of p53 and p21(87).
7. Green tea
tea containing more amount of antioxidants than any drinks or food with
the same volume, is the leaves of Camellia sinensis, undergone
minimal oxidation during processing, originated from China. Green tea
has been a precious drink in traditional Chinese culture and used
exceptional in socialization for more than 4000 thousand years. Because
of their health benefits, they have been cultivated for commercial
purposes all over the world.
Green tea
catechins (GTCs), a potent chemical constituent
containing (-)-epigallocathechin, (-)-epicatechin,
(-)-epigallocatechin-3-gallate, (-)-epicatechin-3-gallate, in treatment
of preprostate cancer men reduced lower urinary tract symptoms, improved
coexistent benign prostate hyperplasia and reached a statistical significance in the case of International Prostate Symptom Scores(88).
In green tea
polyphenols study, epigallocatechin-3-gallate (EGCG) exerted its anti
cancer effect on signaling pathways in PCa(89). Also combination
admiration of quercetin and green tea,
showed a significant increase in the inhibition of proliferation,
androgen receptor and phosphatidylinositol 3-kinase/Akt signaling(tumor
genesis in early stage), and stimulation of apoptosis(90). In short,
Green tea, a potent anti prostate cancer with activities of heritable
alterations of gene expression and chromatin organization without
changes in DNA sequence induced multistep process of carcinogenesis(91)
may be considered as a natural treatment in vary types of cancer.
8. Fermented soybean products
Fermented soybean products are made from fermenting soybeans and filamentous fungus, along with water and salt after a period of sometime.
In the Japan, incidence
of prostate caner in aging men are low compared with the Western
world, suggestion of these result may be tradition Japanese diet
related. Consumption of fish, all soybean products, tofu (bean curds), and natto (fermented soybeans)
was associated with decreased risk of ORs (Estimates of age-adjusted
odds ratios) which supported traditional Japanese diet rich in soybean products and fish against prostate cancer(92). In China, suggestion of reduced risk of prostate cancer
associated with consumption of soy foods and isoflavones found
abundantly in fermented soybean products(93). Unfortunately, the
epidemiological data, linking ferment soybean products to reduced risk
of prostate cancer are inconsistent including miso.
The prevalence and widespread of prostate cancer may be diet,
demographic and life style related disease(94)(95)(96). Suggestions and
intentions are for prevention of prostate cancer to develop in the first
place or used conjunction with conventional medicine in treating the
disease. Eating healthy, with plenty of vegetables and fruits has always
been considered as a preventive engagement in human history. "Let foods
be your medicine and let medicine be your foods" by Greek physician
Hippocrates (460-377 BC).
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(1) Phytochemicals from cruciferous vegetables, epigenetics, and prostate cancer prevention by W Watson G, M Beaver L, E Williams D, H Dashwood R, Ho E.(PubMed)
(2) Activation of AMP-activated protein kinase by 3,3'-Diindolylmethane (DIM) is associated with human prostate cancer cell death in vitro and in vivo by Chen D, Banerjee S, Cui QC, Kong D, Sarkar FH, Dou QP.(PubMed)
(3) Antiproliferative activity of the dietary isothiocyanate erucin, a bioactive compound from cruciferous vegetables, on human prostate cancer cells by Melchini A, Traka MH, Catania S, Miceli N, Taviano MF, Maimone P, Francisco M, Mithen RF, Costa C.(PubMed)
(4) Promoter de-methylation of cyclin D2 by sulforaphane in prostate cancer cells by Hsu A, Wong CP, Yu Z, Williams DE, Dashwood RH, Ho E.(PubMed)
(5) Low prostate concentration of lycopene is associated with development of prostate cancer in patients with high-grade prostatic intraepithelial neoplasia by Mariani S1, Lionetto L2, Cavallari M3, Tubaro A4, Rasio D5, De Nunzio C6, Hong GM7, Borro M8, Simmaco M9.(PubMed)
(6) A prospective study of tomato products, lycopene, and prostate cancer risk by Giovannucci E, Rimm EB, Liu Y, Stampfer MJ, Willett WC.(PubMed)
(7) A prospective study of lycopene and tomato product intake and risk of prostate cancer by Kirsh VA, Mayne ST, Peters U, Chatterjee N, Leitzmann MF, Dixon LB, Urban DA, Crawford ED, Hayes RB(PubMed)
(8) Lycopene/Tomato consumption and the risk of prostate cancer: a systematic review and meta-analysis of prospective studies by Chen J, Song Y, Zhang L.(PubMed)
(9) The role of tomato products and lycopene in the prev29ntion of prostate cancer: a meta-analysis of observational studies by Etminan M, Takkouche B, Caamaño-Isorna F.(PubMed)
(10) Alpha-tomatine attenuation of in vivo growth of subcutaneous and orthotopic xenograft tumors of human prostate
carcinoma PC-3 cells is accompanied by inactivation of nuclear
factor-kappa B signaling by Lee ST, Wong PF, He H, Hooper JD, Mustafa
(11) Alpha-tomatine induces apoptosis and inhibits nuclear factor-kappa B activation on human prostatic adenocarcinoma PC-3 cells by Lee ST, Wong PF, Cheah SC, Mustafa MR.(PubMed)
(12) Lower prostate cancer risk in men
with elevated plasma lycopene levels: results of a prospective analysis
by Gann PH, Ma J, Giovannucci E, Willett W, Sacks FM, Hennekens CH,
Stampfer MJ.(PubMed)
(13) Inverse associations between plasma lycopene and other carotenoids and prostate cancer by Lu QY, Hung JC, Heber D, Go VL, Reuter VE, Cordon-Cardo C, Scher HI, Marshall JR, Zhang ZF.(PubMed)
(14) Lycopene and apo-12'-lycopenal reduce cell proliferation and alter cell cycle progression in human prostate cancer cells by Ford NA, Elsen AC, Zuniga K, Lindshield BL, Erdman JW Jr.(PubMed)
(15) Lycopene inhibits the growth of human androgen-independent prostate cancer cells in vitro and in BALB/c nude mice by Tang L, Jin T, Zeng X, Wang JS.(PubMed)
(16) Allium vegetables and risk of prostate cancer: evidence from 132,192 subjects by Zhou XF, Ding ZS, Liu NB.(PubMed)
(17) Allium vegetables and risk of prostate cancer: a population-based study by Hsing AW, Chokkalingam AP, Gao YT, Madigan MP, Deng J, Gridley G, Fraumeni JF Jr.(PubMed)
(18) Allium vegetables and risk of prostate cancer: a population-based study by Hsing AW, Chokkalingam AP, Gao YT, Madigan MP, Deng J, Gridley G, Fraumeni JF Jr.(PubMed))
(19) S-allylcysteine induces cell cycle arrest and apoptosis in androgen-independent human prostate cancer cells by Liu Z, Li M, Chen K, Yang J, Chen R, Wang T, Liu J, Yang W, Ye Z(PubMed).
(20) Expression of caspases 3, 6 and 8 is
increased in parallel with apoptosis and histological aggressiveness of
the breast lesion by Vakkala M, Pääkkö P, Soini Y.(PubMed)
(21) Effects of diallyl disulfide (DADS) on expression of apoptosis associated proteins in androgen independent human prostate cancer
cells (PC-3) by Gayathri R, Gunadharini DN, Arunkumar A, Senthilkumar
K, Krishnamoorthy G, Banudevi S, Vignesh RC, Arunakaran J.(PubMed)
(22) Polyphenol-rich sweet potato greens extract inhibits proliferation and induces apoptosis in prostate cancer cells in vitro and in vivo by Karna P, Gundala SR, Gupta MV, Shamsi SA, Pace RD, Yates C, Narayan S, Aneja R.(PubMed)
(23) Polar biophenolics in sweet potato greens extract synergize to inhibit prostate cancer cell proliferation and in vivo tumor growth by Gundala SR, Yang C, Lakshminarayana N, Asif G, Gupta MV, Shamsi S, Aneja R.(PubMed)
(24) Ginger phytochemicals exhibit synergy to inhibit prostate cancer cell proliferation by Brahmbhatt M, Gundala SR, Asif G, Shamsi SA, Aneja R.(PubMed)
(25) Benefits of whole ginger extract in prostate cancer by Karna P, Chagani S, Gundala SR, Rida PC, Asif G, Sharma V, Gupta MV, Aneja R.(PubMed)
(26) Enterohepatic re-circulation of bioactive ginger phytochemicals is associated with enhanced tumor growth-inhibitory activity of ginger extract by Gundala SR, Mukkavilli R, Yang C, Yadav P, Tandon V, Vangala S, Prakash S, Aneja R.(PubMed)
(27) A case-control study of prostatic cancer with reference to dietary habits by Oishi K, Okada K, Yoshida O, Yamabe H, Ohno Y, Hayes RB, Schroeder FH.(PubMed)
(28) Prospective study of fruit and vegetable intake and risk of prostate cancer by Kirsh VA, Peters U, Mayne ST, Subar AF, Chatterjee N, Johnson CC, Hayes RB; Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial.(PubMed)
(29) Enterohepatic re-circulation of bioactive ginger phytochemicals is associated with enhanced tumor growth-inhibitory activity of ginger extract by Gundala SR, Mukkavilli R, Yang C, Yadav P, Tandon V, Vangala S, Prakash S, Aneja R.(PubMed)
(30) Unique natural antioxidants (NAOs) and derived purified components
inhibit cell cycle progression by downregulation of ppRb and E2F in
human PC3 prostate cancer cells by Bakshi S, Bergman M, Dovrat S, Grossman S.(PubMed)
(31) Slowing tumorigenic progression in TRAMP mice and prostatic carcinoma cell lines using natural anti-oxidant from spinach,
NAO--a comparative study of three anti-oxidants by Nyska A, Suttie A,
Bakshi S, Lomnitski L, Grossman S, Bergman M, Ben-Shaul V, Crocket P,
Haseman JK, Moser G, Goldsworthy TL, Maronpot RR.(PubMed)
(32) Effect of capsaicin on prostate cancer cells by Díaz-Laviada I.(PubMed)
(33) Capsaicin, a component of red peppers, inhibits the growth of androgen-independent, p53 mutant prostate cancer cells by Mori A, Lehmann S, O'Kelly J, Kumagai T, Desmond JC, Pervan M, McBride WH, Kizaki M, Koeffler HP.(PubMed)
(34) Capsaicin, a component of red peppers, induces expression of androgen receptor via PI3K and MAPK pathways in prostate LNCaP cells by Malagarie-Cazenave S, Olea-Herrero N, Vara D, Díaz-Laviada I.(PubMed)
(35) Apoptosis induced by capsaicin in prostate
PC-3 cells involves ceramide accumulation, neutral sphingomyelinase,
and JNK activation by Sánchez AM, Malagarie-Cazenave S, Olea N, Vara D,
Chiloeches A, Díaz-Laviada I.(PubMed)
(36) Prostate cancer and dietary carotenoids by Norrish AE, Jackson RT, Sharpe SJ, Skeaff CM.(PubMed)
(37) Supplemental and dietary vitamin E, beta-carotene, and vitamin C intakes and prostate cancer
risk by Kirsh VA, Hayes RB, Mayne ST, Chatterjee N, Subar AF, Dixon LB,
Albanes D, Andriole GL, Urban DA, Peters U; PLCO Trial.(PubMed)
(38) Relationship between vegetable and carotene intake and risk of prostate cancer: the JACC study by Umesawa M, Iso H, Mikami K, Kubo T, Suzuki K, Watanabe Y, Mori M, Miki T, Tamakoshi A; JACC Study Group(PubMed)
(39) Prostate cancer and supplementation with alpha-tocopherol and beta-carotene:
incidence and mortality in a controlled trial by Heinonen OP, Albanes
D, Virtamo J, Taylor PR, Huttunen JK, Hartman AM, Haapakoski J, Malila
N, Rautalahti M, Ripatti S, Mäenpää H, Teerenhovi L, Koss L, Virolainen
M, Edwards BK.(PubMed)
(40)Anti-inflammatory and anticancer activities of extracts and compounds from the mushroom Inonotus obliquus by Ma L, Chen H, Dong P, Lu X.(PubMed)
(41)Cytotoxic effect of oyster mushroom Pleurotus ostreatus on human androgen-independent prostate cancer PC-3 cells by Gu YH, Sivam G.(PubMed)
(42) Polysaccharide-K augments docetaxel-induced tumor suppression and
antitumor immune response in an immunocompetent murine model
of human prostate cancer by Wenner CA, Martzen MR, Lu H, Verneris MR, Wang H, Slaton JW.(PubMed)
(43) Isoliquiritigenin inhibits migration and invasion of prostate cancer cells: possible mediation by decreased JNK/AP-1 signaling by Kwon GT, Cho HJ, Chung WY, Park KK, Moon A, Park JH.(PubMed)
(44) Isoliquiritigenin (ISL) inhibits ErbB3 signaling in prostate cancer cells by Jung JI, Chung E, Seon MR, Shin HK, Kim EJ, Lim SS, Chung WY, Park KK, Park JH.(PubMed)
(45) Isoliquiritigenin induces apoptosis by depolarizing mitochondrial membranes in prostate cancer cells by Jung JI, Lim SS, Choi HJ, Cho HJ, Shin HK, Kim EJ, Chung WY, Park KK, Park JH.(PubMed)
(46) Selective modulation of endoplasmic reticulum stress markers in prostate cancer cells by a standardized mangosteen fruit extract by Li G1, Petiwala SM1, Pierce DR1, Nonn L2, Johnson J(PubMed)
(47) Polyphenols from the mangosteen (Garcinia mangostana) fruit for breast and prostate cancer by Li G, Thomas S, Johnson JJ.(PubMed)
(48) α-Mangostin, a xanthone from mangosteen fruit, promotes cell cycle arrest in prostate cancer
and decreases xenograft tumor growth by Johnson JJ, Petiwala SM, Syed
DN, Rasmussen JT, Adhami VM, Siddiqui IA, Kohl AM, Mukhtar H.(PubMed)
(49) Piperlongumine promotes autophagy via inhibition of Akt/mTOR signalling and mediates cancer cell death by Makhov P, Golovine K, Teper E, Kutikov A, Mehrazin R, Corcoran A, Tulin A, Uzzo RG, Kolenko VM.(PubMed)
(50) Piperlongumine induces rapid depletion of the androgen receptor in human prostate cancer cells by Golovine KV, Makhov PB, Teper E, Kutikov A, Canter D, Uzzo RG, Kolenko VM.(PubMed)
(51) Piperine inhibits the proliferation of human prostate cancer cells via induction of cell cycle arrest and autophagy by Ouyang DY, Zeng LH, Pan H, Xu LH, Wang Y, Liu KP, He XH.(PubMed)
(52) Pomegranate extract inhibits the bone metastatic growth of human prostate cancer
cells and enhances the in vivo efficacy of docetaxel chemotherapy by
Wang Y, Zhang S, Iqbal S, Chen Z, Wang X, Wang YA, Liu D, Bai K,
Ritenour C, Kucuk O, Wu D.(PubMed)
(53) Ellagic acid inhibits migration and invasion by prostate cancer cell lines by Pitchakarn P, Chewonarin T, Ogawa K, Suzuki S, Asamoto M, Takahashi S, Shirai T, Limtrakul P.(PubMed)
(54) Pomegranate Juice Metabolites, Ellagic Acid and Urolithin A, Synergistically Inhibit Androgen-Independent Prostate Cancer Cell Growth via Distinct Effects on Cell Cycle Control and Apoptosis by Vicinanza R, Zhang Y, Henning SM, Heber D.(PubMed)
(55) Inhibition of cancer cell
proliferation and suppression of TNF-induced activation of NFkappaB by
edible berry juice by in D, Blanchette M, Barrette S, Moghrabi A,
Béliveau R.(PubMed)
(56)Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro by Seeram NP, Adams LS, Zhang Y, Lee R, Sand D, Scheuller HS, Heber D.(PubMed)
(57)Isolation and identification of strawberry phenolics with antioxidant and human cancer cell antiproliferative properties by Zhang Y, Seeram NP, Lee R, Feng L, Heber D.(PubMed)
(58) Dietary flavonoid fisetin: a novel dual inhibitor of PI3K/Akt and mTOR for prostate cancer management by Adhami VM, Syed DN, Khan N, Mukhtar H.(PubMed)
(59) Activation of AMPK by pterostilbene suppresses lipogenesis and cell-cycle progression in p53 positive and negative human prostate cancer cells by Lin VC, Tsai YC, Lin JN, Fan LL, Pan MH, Ho CT, Wu JY, Way TD.(PubMed)
(60) Biological activity of piceatannol: leaving the shadow of resveratrol by Piotrowska H, Kucinska M, Murias M.(PubMed)
(61) Antiproliferative effects of apple peel extract against cancer cells by Reagan-Shaw S, Eggert D, Mukhtar H, Ahmad N.(PubMed)
(62) Does an apple a day keep the
oncologist away by Gallus S, Talamini R, Giacosa A, Montella M,
Ramazzotti V, Franceschi S, Negri E, La Vecchia C.(PubMed)
(63) Dietary isothiocyanate mediated apoptosis of human cancer cells is associated with Bcl-xL phosphorylation by Basu A, Haldar S.(PubMed)
(64) Roles of diet, lifetime physical activity and oxidative DNA damage in the occurrence of prostate cancer
among men in Klang Valley, Malaysia by Shahar S, Shafurah S, Hasan
Shaari NS, Rajikan R, Rajab NF, Golkhalkhali B, Zainuddin ZM.(PubMed)
(65) Multitargeted therapy of cancer by lycopene by van Breemen RB, Pajkovic N.(PubMed)
(66) Phytosterol Pygeum africanum regulates prostate cancer in vitro and in vivo by Shenouda NS, Sakla MS, Newton LG, Besch-Williford C, Greenberg NM, MacDonald RS, Lubahn DB.(PubMed)
(67)Associations of whole-blood fatty acids and dietary intakes with prostate cancer
in Jamaica by Jackson MD, Walker SP, Simpson-Smith CM, Lindsay CM,
Smith G, McFarlane-Anderson N, Bennett FI, Coard KC, Aiken WD, Tulloch
T, Paul TJ, Wan RL.(PubMed)
(68)Inhibition of prostate cancer cell growth by an avocado extract: role of lipid-soluble bioactive substances by Lu QY, Arteaga JR, Zhang Q, Huerta S, Go VL, Heber D(PubMed)
(69) A case control study on prostate cancer in Delhi by Tyagi B, Manoharan N, Raina V.(PubMed)
(70) Citrus consumption and cancer incidence: the Ohsaki cohort study by Li WQ, Kuriyama S, Li Q, Nagai M, Hozawa A, Nishino Y, Tsuji I.(PubMed)
(71) Potent anti-cancer effects of citrus peel flavonoids in human prostate xenograft tumors by Lai CS, Li S, Miyauchi Y, Suzawa M, Ho CT, Pan MH.(PubMed)
(72) Citrus fruits intake and prostate cancer risk: a quantitative systematic review by Bae JM, Lee EJ, Guyatt G.(PubMed)
(73) Bitter melon extract impairs prostate cancer cell-cycle progression and delays prostatic intraepithelial neoplasia in TRAMP model by Ru P, Steele R, Nerurkar PV, Phillips N, Ray RB.(PubMed)
(74) Ribosome-inactivating proteins isolated from dietary bitter melon
induce apoptosis and inhibit histone deacetylase-1 selectively in
premalignant and malignant prostate cancer cells by Xiong SD, Yu K, Liu XH, Yin LH, Kirschenbaum A, Yao S, Narla G, DiFeo A, Wu JB, Yuan Y, Ho SM, Lam YW, Levine AC.(PubMed)
(75) Momordica charantia leaf extract suppresses rat prostate cancer
progression in vitro and in vivo by Pitchakarn P, Ogawa K, Suzuki S,
Takahashi S, Asamoto M, Chewonarin T, Limtrakul P, Shirai T.(PubMed)
(76) Flaxseed-derived enterolactone is inversely associated with tumor cell proliferation in men with localized prostate cancer by Azrad M, Vollmer RT, Madden J, Dewhirst M, Polascik TJ, Snyder DC, Ruffin MT, Moul JW, Brenner DE, Demark-Wahnefried W.(PubMed)
(77) Effect of flaxseed supplementation on prostatic carcinoma in transgenic mice BY Lin X, Gingrich JR, Bao W, Li J, Haroon ZA, Demark-Wahnefried W.(PubMed)
(78) Flaxseed supplementation (not dietary fat restriction) reduces prostate cancer
proliferation rates in men presurgery by Demark-Wahnefried W, Polascik
TJ, George SL, Switzer BR, Madden JF, Ruffin MT 4th, Snyder DC, Owzar K,
Hars V, Albala DM, Walther PJ, Robertson CN, Moul JW, Dunn BK, Brenner
D, Minasian L, Stella P, Vollmer RT.(PubMed)
(79) Men who consume vegetable oils rich in monounsaturated fat: their dietary patterns and risk of prostate cancer (New Zealand) by Norrish AE, Jackson RT, Sharpe SJ, Skeaff CM.(PubMed)
(80) Selectively hydrogenated soybean oil exerts strong anti-prostate cancer activities by Jung MY, Choi NJ, Oh CH, Shin HK, Yoon SH.(PubMed)
(81) Chrysin reduces proliferation and induces apoptosis in the human prostate cancer cell line pc-3 by Samarghandian S, Afshari JT, Davoodi S.(PubMed)
(82)Chickpea (Cicer arietinum) and other plant-derived protease inhibitor concentrates inhibit breast and prostate cancer cell proliferation in vitro. by Magee PJ, Owusu-Apenten R, McCann MJ, Gill CI, Rowland IR.(PubMed)
(83) Analgesic, anti-inflammatory and anticancer activities of extra virgin olive oil by Fezai M, Senovilla L, Jemaà M, Ben-Attia M(PubMed).
(84) Modulatory effects of polyphenols on apoptosis induction: relevance for cancer prevention by D'Archivio M, Santangelo C, Scazzocchio B, Varì R, Filesi C, Masella R, Giovannini C.(PubMed)
(85) Apoptosis in cancer and atherosclerosis: polyphenol activities by Giovannini C, Scazzocchio B, Varì R, Santangelo C, D'Archivio M, Masella R.(PubMed)
(86) Piperine, a Bioactive Component of Pepper Spice Exerts Therapeutic Effects on Androgen Dependent and Androgen Independent Prostate Cancer
Cells by Samykutty A, Shetty AV, Dakshinamoorthy G, Bartik MM, Johnson
GL, Webb B, Zheng G, Chen A, Kalyanasundaram R, Munirathinam G.(PubMed)
(87) β-Caryophyllene oxide inhibits growth and induces apoptosis through
the suppression of PI3K/AKT/mTOR/S6K1 pathways and ROS-mediated MAPKs
activation by Park KR, Nam D, Yun HM, Lee SG, Jang HJ, Sethi G, Cho SK, Ahn KS.(PubMed)
(88) Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate
intraepithelial neoplasia: a preliminary report from a one-year
proof-of-principle study by Bettuzzi S, Brausi M, Rizzi F, Castagnetti
G, Peracchia G, Corti A.(PubMed)
(89) Modulation of signaling pathways in prostate cancer by green tea polyphenols by Khan N, Mukhtar H.(PubMed)
(90)Enhanced inhibition of prostate cancer xenograft tumor growth by combining quercetin and green tea by Wang P, Vadgama JV, Said JW, Magyar CE, Doan N, Heber D, Henning SM.(PubMed)
(91) Epigenetic effects of green tea polyphenols in cancer by Henning SM, Wang P, Carpenter CL, Heber D.(PubMed)
(92) A case-control study of diet and prostate cancer
in Japan: possible protective effect of traditional Japanese diet by
Sonoda T, Nagata Y, Mori M, Miyanaga N, Takashima N, Okumura K, Goto K,
Naito S, Fujimoto K, Hirao Y, Takahashi A, Tsukamoto T, Fujioka T, Akaza
(93) Soy and isoflavone consumption in relation to prostate cancer risk in China by Lee MM, Gomez SL, Chang JS, Wey M, Wang RT, Hsing AW.(PubMed)
(94) Soy intake and cancer risk: a review of the in vitro and in vivo data by Messina MJ, Persky V, Setchell KD, Barnes S.(PubMed)
(94) Mediterranean Diet and Prostate Cancer
Risk and Mortality in the Health Professionals Follow-up Study by
Kenfield SA, Dupre N, Richman EL, Stampfer MJ, Chan JM, Giovannucci EL.(PubMed)
(95) A prospective study of demographics, diet, and prostate cancer among men of Japanese ancestry in Hawaii by Severson RK, Nomura AM, Grove JS, Stemmermann GN.(PubMed)
(96) Alcohol consumption, smoking, and other risk factors and prostate cancer in a large health plan cohort in California (United States) by Hiatt RA, Armstrong MA, Klatsky AL, Sidney S.(PubMed)
Health Researcher and Article Writer. Expert in Health Benefits of Foods, Herbs, and Phytochemicals. Master in Mathematics & Nutrition and BA in World Literature and Literary criticism. All articles written by Kyle J. Norton are for information & education only.
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Wednesday, 29 January 2014
Prostate cancer in Foods' Points of View
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Underworld by Greg Cox series
Underworld By Greg Cox Series
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I tend to be a bit picky when it comes to vampire movies. I don't really need them to be unique, to show me something new about the vampire or to even be works of art. Mostly, I just want to be entertained with the general myth being adhered to.
That's why I love the Underworld movies. A lot of folks look at me strangely when I say it is one of my favourite – if not favourite – vampire movie series. They talk of poor acting and bad lines, but I like the acting and I thought the lines worked. I'm not after Oscar-award-winning performances.
My favourite part of the trilogy is the sheer thought that has gone into the world-building of the Underworld universe. I think I liked the third movie, Rise of the Lycans, the most, as it tells the story of how the feud came about, of why Lucien hates vampires and why Viktor is so hell-bent on destroying Michael, a vampire/werewolf hybrid.
There is no sleeping in coffins or stakes through the heart – humans generally die if they're bitten by a vampire – but sunlight is deadly. Humans are noticed about as much as we notice cattle in a field; they're a curiosity, but not important to a vampire's daily life.
Rather than summarise each movie, it is perhaps better to look at the mythology of the universe itself, as this is what I love anyway. N.B.: Spoilers do abound.
In this universe, immortality was an accident, a mere genetic fluke. Alexander Corvinus, the first immortal, was the only survivor of a plague that killed everyone it touched. He had three sons, Markus, William, and another. One son was bitten by a bat, one was bitten by wolf and one remained human. Markus and William were the very first vampire and werewolf while the human child carried the immortal gene in a dormant form.
William was uncontrollable; everyone he bit rose as a 'wolf, but with no control, no ability to turn human again. The werewolf gene was like a curse, unstoppable and uncontrollable. Markus, in order to save his brother, made a deal with a local king, Viktor, who he transformed into a vampire in order to help prevent his brother's rampages. But Viktor tricked Markus, locking William away and forcing Markus to pretend he wasn't the first of their kind.
Viktor then studied the werewolves created by William, hoping to control them somehow, as he wanted guards that would protect his vampire clan during the daytime. Eventually, a baby was born to a 'wolf: Lucien. Viktor thought to kill him, but decided to wait, hoping that his werewolf guard was still a possibility. And it was.
Lucien - number one Lycan
Lucien was really the first werewolf, a true Lycan. He could control his transformations and those he bit also were able to return to human form. He was strong – he didn't need the full moon in order to change form. He was also dominant; the werewolves created by William obeyed Lucien as if he were their true master.
However, Viktor's plans went awry: he didn't count on his daughter falling in love with Lucien or the fact that she would fall pregnant with his child. Horrified by the mixing of the lines, Viktor exposed his only child to the sunlight and let her perish in front of Lucien's eyes.
Daddy's girl?
And so began the war that lasted centuries: werewolves against vampires. This is where the first movie begins, with Selene, a Death Dealer with a striking resemblance to Viktor's daughter, hunting werewolves who are trailing the human, Michael Corvin. Intrigued as to why a human would be of interest to werewolves, she follows the young doctor.
Only to have the reasons for the war start all over again.
Michael Corvin
The fourth instalment of the Underworld universe is due out next year. I'm rather looking forward to it.
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text: This two days package trip offers a glimpse into the agrarian life of the vibrant southern Delta region by bending its way through the branches of the Mekong Delta in Sa Dec area. You will have a chance to enjoy local cuisine at an ancient traditional house and visit Chinese temples, which were built and preserved for centuries, by the riverbed. From our private Sampan, you will be able to sight the daily rituals of river life and participate in the bustling commercial activities.


text:
A 9% increase in burglaries means it has become the biggest fear for 22% of UK homeowners over the Christmas period, according to research from HomeServe Labs.
The second biggest fear is a water leak causing damage (17%) ahead of fire causing damage to the home (15%), the boiler breaking (14%) and power cuts (13%).
This year, 68% of UK consumers will be spending the festive period at home with family, but fears increase for the 32% spending Christmas away from home.
HomeServe Labs' top 5 tips to alleviate fears over Christmas are:
1. Make your home looks like someone is living in it
Use automatic timer-switches to turn your lights and radios on when it goes dark and cancel any newspaper or milk deliveries. Avoid discussing holiday plans on public social networking sites - burglars can use any information you post on there to their advantage.
2. Create a power-outage kit
Prepare for winter power failures by pulling together emergency kit complete items such as an electric torch, batteries, food, water and blankets.
3. Protect against leaks
Water leaks are the second biggest problems people report in claims to insurers in the world. Ensure you are protected by looking out for tell tale signs and consider turning off the stop valve of the water supply where it comes into the home. For smaller leaks that are harder to detect but can cause significant damage over time you should consider leak alarms or speak to a home assistance provider.
4. Curb unanticipated winter emergencies with extra protection
Water pipes that are not properly drained, or left unused during the winter, can freeze, expand and possibly burst. Take proactive measures such as checking and insulating the cold water lines near exterior walls or in crawl spaces.
5. Check the heating system
A strong, short-lasting smell is common when starting up the heating system for the first time in the season, but if that odd smell lasts or reoccurs, shut down the system immediately and call a professional.
Nick Lobban, SVP of operations at HomeServe Labs, said: "The holiday season is something that many people look forward to, but it can also cause angst. The last thing people need is a burglary while they are away or a problem in the home.
"Homeowners can benefit from looking into the latest connected home technologies now that can help prevent burglaries and leaks happening to help ensure a stress free Christmas period. By careful planning – from having a household MOT check before people come to stay – you can make sure everything is in order so you can focus on having a horror free holiday and enjoy the things that really matter."


text:
Olaplex is the original, unique and patented chemistry that multiplies bonds and cross-links broken bonds. Olaplex did not create a product category – Olaplex is the product category.
Olaplex gives colourists confidence, the insurance and the ability to colour or lighten hair at any level without the risk of breakage. This new and unique chemistry has 8 worldwide patents and has been tested thousands of times, putting samples of hair through extreme processes that would never be attempted in reality.
Olaplex can be used in your colour services or as a stand-alone treatement, with its single active ingredient repairing the hair from within. The result is stronger and healthier hair, plus colour lasts longer with more vibrancy.
From keratin treatments to perms, balayage to full bleaching, you will find that your client's hair can withstand more than you ever thought possible with this revolutionary product.
Keune has a strong focus on professional hair colour, styling and care. All products are developed in one of Europe's most advanced hair cosmetic laboratories, where the highest quality, most sophisticated ingredients and the use of innovative hair technology is combined together to create products which provide reliable & consistent solutions to people's hair needs, wants and desires.
Color Defence, Hair Colour Maintenance System
Color Defence, the next generation in personalised hair colour maintenance, is a unique and simple personalised 3-step system that maintains the vibrancy, shine and condition of freshly coloured hair and eliminates colour fade, no matter what the colour. As simple as three easy steps: step 1 cleanse; step 2 tone; step 3 moisturise, tone and condition.
What causes hair colour to fade? Stress from constant washing and blowdrying; the use of thermal styling tools (straightening and curling irons); and exposure to surf, sun and chlorine.
Color Defence contains the 3-defence complex system™, a set of ingredients with unique properties that provide protection against oxidation (superoxide dismutase enzyme), free radical damage (melanin) and environmental damage (wasabia japonica root extract).
Color Defence colour maintenance system provides colourists with the means to personalise a maintenance program that will maintain the vibrancy, shine and condition of individual hair color through to a client's next colour service.
Color Defence is produced using sustainable, renewable ingredients and packaging and is manufactured in Belgium by Codibel in a world-class environmentally sustainable production environment. A new, cutting-edge, Triple ISO rated production and manufacturing facility, which generates its own electricity through solar and wind power to ensure its low carbon footprint, and exceeds all European environmental control standards in terms of factory emissions and waste.
We have uniquely blended coconut, Moroccan Argan, jojoba and macadamia oil to make the perfect repairing, hydrating and strengthening potion for your hair.
Repair me has been Specially formulated to protect your hair from heat, sun and chemicals such as chlorine and will help tame flyways, cut blow drying time, encourage hair growth and help to prevent split ends.
Argan oil is proven to make hair silkier, shinier and softer, and it can even help to tame split ends and tame frizzy hair.
Coconut oil stimulates hair growth by getting deep into the follicles and promote a healthy scalp.
Macadamia nut oil provides hair nourishment and helps to prevent against hair breakage by penetrating the scalp and hair follicles to improve hair strength and elasticity.
Repair, hydrate, rejuvenate.
Jojoba oil is one of the best oils for dry damaged hair and split ends along with other problems such as hair loss and Danduff and and hair that is prone to tangling.
Jojoba oil acts to keep your hair tangle free,well moisturized (including the scalp) encourages hair growth and Shine.


text:
Submitted, with thanks, by OCISO founding Board member, Ariella DalFarra Hostetter
Those early OCISO Board meetings were intense.
When Sal looked up at the ceiling and asked: "How much are we paying for the ceiling fluorescent bulbs?", I really could not believe it.
We had been carrying on a debate about major financial issues on how to meet payroll and pay the rent. What a question. 425 Gloucester Street was not "grade A" office space but light bulbs were surely included in the rent. I didn't really know Sal Carioto.
Having grown up in Scarborough, Ontario and migrated to Ottawa when I had met Fred, the love of my life, several years before, I did not know many people in the Ottawa Italian community.
With experience in Toronto as a volunteer on an immigrant women orientation outreach program under my belt, I wanted to play a part in getting this new organization up and running.
That I was an immigrant from Italy was somewhat secondary in my motivation being on the OCISO board. My links to the Board were through the Ottawa YM/YWCA.
Some of us who had been together when a new immigrant/refugee settlement organization was at the idea stage knew each other, but on that first Board of Directors, newly enshrined with a set of registered bylaws, there were many individuals and organizations that were new to each other.
With places on this board for representatives of 'ethnic' organizations this group was as multicultural as you could find anywhere. There were Italians, Jamaicans, Trinidadians, Lebanese and East Indians to name a few.
To my knowledge all the associations represented had members in need of settlement help or needing support in navigating Canadian bureaucracies.
Some of us were individual members. I don't remember all the first board members but what I do remember is that there was a tremendous and varied skill set.
Looking back, I realize that associations had sent their most talented individuals to represent them and to help establish an organization that would serve the Ottawa Carleton community in the long term.
Sal Carioto's comment? Over the years I did get to know Sal, who passed away at the age of 92 in 2016. I now think that he probably wanted to steer the debate in another direction. A little less heated perhaps.


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At TruSTAR we're constantly working with our SOC team users to gather feedback about how to make our product better.
Today we're introducing Enclave Tags, a new tagging feature specifically designed for Private Enclave users who are often working cases across different shifts, teams, and time zones.
Streamline Analysis Workflow
Continuity of incident analysis can be challenging for security operator teams consisting of multiple members, as they have to ensure the appropriate information is captured with Incident Reports. With Enclave Tags, operators can share specific TruSTAR reports more easily by categorizing them based on internal naming schemes, such as department names, internal SOC team naming conventions, or ticket numbers. This custom tagging feature reduces redundant workflow and saves time among operator teams.
Increase Searchability
For Private Enclave power users, the number of reports of interest on the TruSTAR platform can get quite large. Custom Enclave Tags will help you find and categorize reports faster. You can sort cases by tags to discover patterns more easily, track specific incidents, or perform audits.
What's the difference between Enclave Tags and Categories?
Enclave Tags and Categories exist on different parts of the TruSTAR platform. Essentially, Enclave tags are private, while Categories are public and available to the wider TruSTAR community.
You can add Enclave Tags to any report on the TruSTAR platform and these will only be visible to members belonging to that Enclave.
You're only prompted to create Categories when you submit a report to the TruSTAR Community. Categories are publicly searchable tags that you select when you create and submit a new report. You can read more about Categories here.
Are Enclave Tags visible to everyone?
No, Enclave Tags are only visible to other members within your Private Enclave.
How To Create an Enclave Tag
Step 1: Pull up any incident and select the Manage button.
Step 2: Enter a new Enclave Tag name, or select an existing tag from the drop-down list of custom Enclave Tags.
Step 3: You will now see all selected Enclave Tags on your report details panel.
Interested in learning more about how you can improve collaboration on TruSTAR? Check out our posts on how to use Chat and how to Save and Share Cases.


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Tag Archives: portals
Doors, portals, passages and gates of Sweden
I'm sure that somewhere, photographic essays – yes, probably entire books, have been assembled on doors and their similes. After all, for being such a simple, utilitarian building element, they are ascribed huge symbolic importance; hope, opening, opportunity, passage, transition from … Continue reading
Posted in On Building, Scandinavia Tagged Östergötland, doors, entryways, functionalist, gates, history, medieval, passages, portals, Sweden, Västergötland 17 Comments


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Short Sighted Pool Plan Gaurantees Lost Money for Long Beach
OPINION – by Jessica Pollack (McCormick Divers Booster Club President)
As posted on www.lbreport.com
After years of patching, wrangling, and making do, the City of Long Beach finally has to come to terms with the need to rebuild the aging Belmont Plaza Olympic Pool. Twelve years ago, the City entertained plans to demolish the pool to build a state-of-the-art facility. Then, following the 9/11 attack in New York City, those plans were put on hold. Again in 2005, another plan was discussed, but never materialized. The facility has limped along, but now cannot continue operating.Read More »Short Sighted Pool Plan Gaurantees Lost Money for Long Beach


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Reflections of Mamie
Reflections of Mamie
First of all, if you are a victim of abuse, be it emotional, mental or physical, IT IS NOT YOUR FAULT! It matters little if you are a child, adult, male or female, abuse is not an acceptable way of life and it is never your fault. If you are an adult and find yourself in this situation, get out! If you are a child, it is more difficult but you can get help...talk to a friend, teacher, church clergyman, police or anyone who holds a position of trust. A spanking for bad behavior does not constitute abuse but a beating is quite another matter.
Abuse, as defined in most dictionaries, is improper or excessive use of treatment or defamation of character through mental abuse, none of which is acceptable.
Abuse is an ugly thing no matter what form it takes. In Webster's Dictionary, abuse is explained as follows: 'a corrupt practice or custom obsolete; a deceitful act: deception; language that condemns or vilifies usually unjustly, intemperately, and angrily; physical maltreatment'.
PLEASE make no mistake, if you have been abused as a child in any way, especially over long periods of time, you must first become free in your spirit BEFORE having children of your own. YOU must first rid yourself of the demons inside you so that you don't risk passing the damage onto your own children and precipitate generational abuse. YOU and only you can make that wise decision.
It took me thirty eight (38) years to be sort of free but fifty four (54) years before I was finally beyond it. It didn't happen until my heart and spirit were ready to accept real love and believing that I deserved it, that I corrected my outlook and began to make wise choices. Only then was I able to recognize a good thing when I saw it. It was then that I met my husband who gave my daughter and I, his devotion, patience, love and commitment forever. It took some time but the day did come when my thoughts were finally free of anxiety, fear and doubt and it came as a revelation that I was indeed, a decent human and worthy of love.
Thank God for love, trust and forgiveness. I only wish I could undo all of the mistakes I made when my heart was so sad instead of lusting for love to fill the void caused by emptiness and rejection. I had many chances to find my way but never saw them as I was too consumed with the grief of never being loved by my mother. I watched her give all her love to my younger brother while my older brother and I meant nothing to her. I suffered her words over and over again. "Why can't you be like your younger brother? Why do you have to be such a huge disappointment? Why can't you just vanish like you do when your father leaves? You'll never mean anything to me!"
I hated her yet loved her for what she was supposed to be to me. Her constant belittlement soon became the image that I held of myself and that can take a lifetime to turn around.
Keep a journal, help someone else, love a pet, find yourself because YOU ARE WORTH IT and deserve to be happy. Love will come to you-just LET IT IN!
Before we get started, the story I'm about to tell is a true reflection of my life. It is as difficult to tell as it was to live through. It took sixteen agonizing years to recover the horrific memories that I thought were hidden from the light forever. I tried but failed to tell my story in the third person but it only served to prevent me from facing the inevitable trauma head on. Instead, I chose to exorcise my demons by writing in the first person, up close and personal as I relived the horrors of my childhood. Some of what you are about to read will be upsetting but it is the only way that I can reach out to those in need.
As we progress through Mamie's life, I show you how desperate I was to escape from my Mother's hateful abuse and how my failed attempts led me down the path of destruction more often than not. And all of this was because of the deprivation of


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Among the special guests attending the June 7 Mass of Thanksgiving for Venerable Aloysius Schwartz at his home church, Holy Name of Jesus in Washington, were four members of the Sisters of Mary, the religious congregation of women he started who continue his legacy of educating poor children around the world.
Later, Sister Elena Belarmino, the order's secretary general who is stationed in her native Philippines, noted it was fitting that Cardinal Wuerl celebrated the Mass on the feast of Corpus Christi.
"The Eucharist is the center of our spiritual life and our work. That is the secret of our work. In every building, we have two chapels with the Blessed Sacrament," she said.
Every day, the Sisters of Mary teach more than 20,000 children at their Boystown and Girlstown programs in six countries – South Korea, the Philippines, Mexico, Brazil, Guatemala and Honduras. Father Aloysius Schwartz, a missionary priest, began the outreach to street children and orphans left destitute after the Korean War and founded the Sisters of Mary in 1964 to help him in that work. The priest died of Lou Gehrig's disease in 1992 after expanding his outreach to the Philippines and Mexico, and today the 380 Sisters of Mary continue his legacy of educating poor children, breaking the poverty cycle, and giving them hope for a brighter future.
Sister Hortencia Olivares now serves as the superior of the Girlstown in Chalco, Mexico, where she attended school and was inspired by the sisters' example to join their community. "I was very attracted to their prayer and their way of life," she said. "…The Sisters of Mary took care of me during the years I was there. They were very caring and concerned for us. That's one thing that made me want their life and to be with them."
When Pope Francis signed a degree in January recognizing that Msgr. Aloysius Schwartz lived a life of heroic virtue and declaring him to be "Venerable," that milestone in the missionary priest's cause for sainthood was joyful news for the Sisters of Mary. Sister Hortencia said the news that "our father is holy" reminds the sisters of their responsibility to help the children whom they serve "to be holy, like Father Al." Her goal for the children who graduate from Girlstown is that they "go with the love of God in them," she said.
Sister Winnie Valencia noted that before attending Girlstown in the Philippines, she lived with her family on Smokey Mountain, an infamous slum located on a garbage dump in Manila.
"It's horrible. The mountain is always burning. In the night you can't sleep… Through God's grace, I was brought by my mother to the Sisters of Mary," she said.
After graduating from Girlstown, she got a good job, and helped support her family. Eventually, she became a Sister of Mary, joining the religious order whose outreach had changed her life. "I owe it to God, God's plan, God's will," said Sister Winnie, who serves at the Girlstown in Mexico.
While Sister Winnie was a student at Girlstown, she witnessed how Msgr. Aloysius Schwartz accepted his suffering from Lou Gehrig's disease with faith and joy. "Father Al always trusted God. 'Everything is in God's hands,' he told us," she said.
In the days before the Mass for Thanksgiving, the Sisters of Mary spoke with children at St. Raphael School in Rockville and St. Bartholomew School in Bethesda about Venerable Aloysius Schwartz and his life and work.
"It is a blessing for us that our founder is a step closer to being a saint," said Sister Elena in a June 3 talk to students at St. Raphael School. "…He is an ordinary person who tried always to do everything for the glory of God. He tried always to do his best for Jesus in everything he did."
Sister Elena said she was visiting them "to encourage all of you to try your best. Even the little things you do, offer to Jesus."
In an interview, Sister Maria Cho, a native of Korea who serves as the mother general for the Sisters of Mary, spoke about the work of the religious community which she joined in 1981. She said Father Schwartz emphasized that "the main purpose of serving the poor is saving their souls."
Sister Elena, who became a member of the Sisters of Mary when the order expanded to her native Philippines in 1985, said that after meeting Father Schwartz, she was inspired by his humility and simplicity. From his life of prayer and service, Sister Elena said she learned that "we have to be united first with Jesus. We have to love Jesus first, before we serve them (the poor). Father Al was busy, but he always had time to pray. He taught us to make time to pray and be united to God. From there, our work overflows to the poor."
The Sisters of Mary pray three hours each day. "It really is God working through us.," she said. "Without prayer, we could not do the work we're doing."
The Sisters of Mary teach children from nursery school through high school at their Girlstown and Boystown programs. Their goal is for the students and graduates to become disciples of Christ, sharing their faith with their families and friends, and at work and in the community.
"Our service is making the world better," said Sister Maria.
The 107,000 graduates of the educational programs begun by Venerable Schwartz and continued by the Sisters of Mary have gone on to become sisters, priests, brothers, doctors, lawyers, engineers, teachers and excel in many other professions.
During his lifetime, Father Al "was always encouraging them (the children), that you can do good, you can do more," Sister Elena said.
When their founder was stricken with Lou Gehrig's disease, "he accepted his sickness as a grace of God. He said it is a sharing of the passion of Christ," she said. "He was like Jesus who was nailed to the cross and could not move. He said it was that suffering that saved the world."
Sister Elena noted how Pope Francis has challenged people to "go out and serve the poor," and that is the spirit that Venerable Schwartz gave to the Sisters of Mary, who continue his work of educating poor children and guiding them to be closer to Jesus.
Today's Catholics can follow his example by getting out of their comfort zones and helping those in need, she said. "That's what Father Al was doing… He can be a great example for everybody. We have to forget ourselves to help others."


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About the Project
* Easy access to İstanbul and Yalova by vehicle.
* Istanbul 90 min by ferry and only 15 min drive to Bursa center.
* Total 56 apartments, consists of 1, 2 and 3 bedroom apartments.
* Sea and nature view
Total land area: 3.445 m2
Total construction area: 6,766 m2
Area of the buildings: 1200 m2
Green area - social areas: 2245 m2 consists of 70 blocks of 6 blocks.
Project Features
* Raft foundation system
* C 30 concrete
* Adult and children's swimming pool
* Security system
* Children's playground
* Outdoor parking
* Fitness Center
* Sauna
* Cafeteria
* Camellia
* Green areas
3+2 dubleks apartments-156sq.m - prices starting from 155.000USD.
You can contact us to benefit from special price advantage and special payment options by clicking here.
Real Estates for Sale in Bursa
Bursa is located in Northern Turkey, a large city with an excellent modern approach playing a huge role in Turkey's economy with two of the main industries being textiles and the car production industry. Bursa is also Turkey's second largest export area next to neighbouring Istanbul which sits on the opposite shores of the Marmara Sea easily accessible by the regular vehicles and ferry services for the passengers.
The city also has a growing affluent population of well-educated citizens, all this making Bursa a hotspot for property invesment for the foreseeable future.
Who Purchase a Property in Bursa?
Apart from Turkish citizens, the main owners of real estate in Bursa are from the Arab countries, who tend to know a good real estate investment when they see one, often buying second homes, holiday homes, or buy-to-let investment properties, and have infused Bursa with millions of $'s over the past few years.
Arabs tend to prefer Turkey to other western areas, mainly because it is a predominantly Muslim country, in which they feel more comfortable and relaxed. Another reason Arabs choose this area is because accommodation for sale In Bursa is often considerably cheaper than in Istanbul, another popular area for Arabs.
Special requests or comments:
SHY EMLAKCILIK TURZ. INS. MUMESSILLIK SAN. TIC. A.Ş. Real Estate and Property Sales in All over Turkey Since 2002 Our company was founded under the registered trade name of SHY A.Ş. both in İzmir and London and started to provide services to international companies and people who..
A warm welcome to you from myvillaturkey.com sales team. Below you can find some information about buying a property in Turkey. The Buying Process Buying a property in Turkey is a relatively simple process but it takes a while due to the military checks. Most people are surprised at how strai..


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Published: 11/10/15
An inewsource analysis found water mains in San Diego broke 306 times between January 1, 2012 and September 30, 2015. Search by location or by the material of the pipe that broke.
Breaks are colored based on estimated water loss.
Related story: New culprit in San Diego water main breaks: asbestos cement
Download the data behind this map here.
Questions, tips or corrections? Email inewsource reporter Joe Yerardi at email@example.com or call him at 619.594.5321. Follow Joe on Twitter at @JoeYerardi.
Source: San Diego Public Utilities Department | Map and analysis by Joe Yerardi | Based on a map template by Derek Eder


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For the last few times I've logged into Second Life, my avatar won't turn toward a selected object or move in another direction unless I turn it with the arrow keys.. This means I have to use individual steps to turn or to go directly to anyplace I want to stand, using individual steps, rather than turning toward or being able to move the camera around object to assist my movement there. I've tried changing various setting, but nothing makes any difference.
I hadn't changed any settings or tried to do anything unusual before this started, so I'm at a loss to explain why this function suddenly disappeared. It certainly makes moving around second life a massive annoyance and impedes my doing things that I would normally do, because I have trouble getting from one place inside an area to another.
Wondered if there are any suggestions about what went wrong, or how to fix it


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The Newquay Loyalty Card Scheme, first introduced in 2012 by Newquay Business Improvement District (BID)has launched a brand new app making it easier for users of the scheme to use and find out the latest offers. The "Love Newquay Loyalty Card App" which has been developed for free through Tribal Digital is now available for Android and IPhones from app stores.
To date there have been almost 20,000 cards distributed to residents of Newquay and Cornwall and requests for cards continue to grow, it has been decided by Newquay BID that no more cards will be printed and that the app will be the new way of users joining the scheme. All distributed cards will still be useable and will run alongside the new app.
Alice Beard, Marketing and Events Coordinator said: "It has been great to see how the Loyalty Card Scheme has grown since I joined the BID in 2012 through requests for cards and the growth of the Loyalty Card Facebook and Twitter pages, plus the number of different businesses that continue to sign up to the scheme. We still occasionally have Loyalty Card users questioning where they can find offers and we think that the Love Newquay Loyalty Card App will make it easier for people to find out new and existing offers. In addition to offers we are also able to promote events that are taking place throughout the year."
Alice continues: "For those residents that don't already know about the Loyalty Card Scheme it is a great way to help support local businesses all year round and ensure that your money is going back into the local economy. The Scheme offers great discounts from everything from 25% off food at Belushi's to 10% discount at Little Gem on East Street all year round. Remember to the like the Facebook page at "Newquay Loyalty Card Scheme" and follow the Twitter page @NQY_Loyalty. "
If you are a business and have any questions about the App, or are resident to Newquay and would like to find out more about the Newquay Loyalty Card Scheme then please email email@example.com.


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Will Jones
Member since: Jun 03, 2015
Published articles: 2
What Every Employee Should Understand About Workers Compensation Insurance
All employers (with the exception of a minimal little) are required to obtain workers compensation insurance for their workers. The scope of the insurance policy is developed to give settlement to the...
Articles > Business & Careers > Negotiation Jun 30, 2015
The Very Best Time to Utilize an Insurance Coverage Broker
If you are preparing to get an insurance coverage but not exactly sure how, it may be time to talk to insurance brokers Perth teams. These are professional brokers with a bunch of expertise and also...
Articles > Legal & Law > Other Jun 03, 2015


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>At 02:27 PM 12/23/96 -0800, Terry Allen wrote: There is no requirement in RFC 1866 that A's NAME be unique within >>the document, and in fact the absence of such a requirement could eventually >>become a feature of HTML by facilitating n-ary links. And HTML's >>definition of a name start character is exactly the RCS's. > >At 04:26 PM 12/27/96 -0900, Eliot Kimber wrote: >Ugh. I didn't realize that. I can see the benefit, although I would think >that 999 times out of a 1000 the intent will be to uniquely identify parts >of HTML documents, especially since none of the Web browsers I know of >support multi-object link ends (at least IE and Netscape don't appear to). > >There is generally a distinction between a "label" and a "name", where >labels need not be unique (ignoring programming languages that use unique >labels) and names, which are unique within some name space. I would argue >that HTML has confused these two and seriously undermined the general >concept of NAME with the NAME attribute of the A element. Note that the Object Proposal does introduce unique IDs: "OBJECT has the following attributes: ID Used to define a document-wide identifier. This can be used for naming positions within documents for use as destinations of hypertext links. An ID attribute value is an SGML NAME token. NAME tokens are formed by an initial letter followed by letters in the range a-z and A-Z (no accented characters), digits, "-" and "." characters. It may also be used by the user agent or objects in the document to find and communicate with other objects embedded in the document." Regards, Ralph E. Ferris Project Manager, Electronic Publications Fujitsu Software CorporationReceived on Saturday, 28 December 1996 13:38:17 UTC
This archive was generated by hypermail 2.4.0 : Friday, 17 January 2020 20:25:06 UTC


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Journey To Seshachalam Hills, Southern India
Fascinated with the ritual of Tonsure we were drawn to India, in particular, the Seshachalam Hills in Southern India. Considered to be one of the largest pilgrimage destinations in the nation, each year millions of pilgrims display their devotion to the deity Venkateswara the destroyer of sins by shaving their tresses as a selfless act in an attempt to achieve spiritual enlightenment. The ritual, in its purest form centers around "letting go".
Selflessness Of The Tonsured
Cleo's co-founders having a curious interest in this ceremony of "letting go". Following the story of these pilgrims, we were lead to the highest quality natural hair extensions. The selflessness of the tonsured pilgrims revealed an ethical source of virgin natural hair extensions that we found to suit the needs of the elegant empowered South African woman.
The Talented Youth
CLEO is a young company with a youthful, talented team at the helm. Although young, our team has the experience where it counts. Cleo's co-founders defy Hair & Beauty industry norms with their talent for distribution and retail while showing a superior understanding of the online marketplace. Together with their team of specialists, Cleo is able to supply an ever growing range of ethically sourced high-quality natural Premium Human Hair Extensions.
Incorrect user ID specified.


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Category: Salon Marketing
Make This Christmas Bright
by Misty Angelique | Salon Marketing, Social Media | 0 |
Facebook Marketing Ideas for December December is one of the most, if not the most, important money making months for your salon. Knowing this, it's crucial that you use all of your marketing platforms to promote your business...Read More
Your Words Say It All
When we think of marketing tactics to use in salons, we tend to think of things we can do to bring clients into our salon: sending emails, running ads, promoting our business on social media. What about things we can do to keep...Read More
Host a Holiday VIP Event
Snow has fallen. Christmas music can be heard on the radio. The stores are already starting to hustle and bustle even though it's not even Thanksgiving yet. If you are a salon owner, this is your time to start raking in some big...Read More
Boost Profits this Valentine's Day
Now that Thanksgiving, Christmas, and New Year's are over, things might be a little quieter around your salon. Those quiet days give everyone a chance to recharge and get ready to provide exceptional customer service but they...Read More
Boost Retail Sales this Holiday
Your books are full thanks to everyone wanting to look their best when they see their family and friends during the holidays so why not use this increase in foot traffic to boost your retail sales, too? With a few key tricks up...Read More
New Year, New Promotions
How many of you are still wiped out from the hustle and bustle of the holidays? The holidays bring about a big increase in sales, full books, and also a drained staff! While you might be mentally ready for a break after all that...Read More
Bananas for Birthdays
by Misty Angelique | General Beauty, Salon Marketing | 0 |
The Forgotten Marketing "Holiday" What's one thing every client in your salon has in common? They all have BIRTHDAYS! Some people like to make a big to-do about their birthday and make it into a week-long affair, while others...Read More
Using SEO to Boost Salon Business
SEO, or search engine optimization, can be a very taxing part of marketing on the internet but...Read More
Make This Holiday Banging With These Marketing Tips
Now that the holidays are around the corner, business everywhere is picking up and we want that to...Read More
The Art of Attracting Client's to Your Salon
There's nothing more daunting and worrisome as a salon owner than having empty chairs and holes in your books. It's not fun for you and it's not fun for your stylists and other salon employees that are counting on their income...Read More
Standing Out Amongst the Crowd
There are BILLIONS of users on social media platforms like Facebook and Instagram. Billions. It can be hard enough trying to compete with the salon down the street from you so how on earth are you supposed to compete with...Read More
Motivate Your Employees and Watch Your Profit Skyrocket!
Are your profits lagging? Sometimes a business has less than desirable results because their staff...Read More
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Color Wine is golden yellow with light greenish highlights. Taste Wine demonstrates a clean, refreshing taste with fruity citrus notesVintage in image may vary. Refer to wine facts for current vintage.
This product is out of stock.
INFO: In 1996, at an age when most people are thinking of retiring, the 3 Canepa sisters, - Gilda, Edda and Antonieta-, responding to their passion for the production of fine wines which has been part of their family's life since the 1930's, and decided to link their well established vineyard holdings to a state-of-the art, brand new winery. This decision marked the founding of TerraMater.
The name TerraMater tells us a lot about the company itself. This is a company which was born from exceptional lands, covered by noble and well established vines that are up to 70 years old, and marvelous olive groves with thick trunks and beautiful green leafage, with more than 50 years, which produce the very best quality Extra Virgin Olive Oil. You can also find apple orchards, which bear their abundant fruit during the summer months.
TerraMater represents the perfect combination of traditional Chilean top quality winemaking practices, the search for innovation and the concern to achieve the very best our vineyards can deliver, through the creation of wines which truly pay homage to the generosity of our Mother Earth.
TerraMater S.A.
750 ml
Maipo Valley


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|Yoshimitsu SUZUKI
|Written by KALONSNET Editor
|Published: January 25 2011
Solo exhibition by Yoshimitsu Suzuki (b. 1988).
Period: January 24 - February 5, 2011
|Last Updated on January 24 2011
The second solo exhibition of Yoshimitsu Suzuki who has held the first solo exhibition in 2kw gallery, Osaka in January. His art has radically changed from the first solo exhibition in which showed works with a chandelier, motorcycle, and merry-go-round, etc. drawn in colorful satin cloth by sketch. This time, his art has radically changed. The spectacle of the plant and ruins are drawn in a monochrome background.


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When: April 12 from 9:30am - 12:00pm
Where: Parma Branch Library, 6996 Powers Boulevard Parma, Ohio 44129 map this
FREE Cuyahoga County Stormwater Control Measure Maintenance Training for Municipal Staff and property owners/management companies maintaining Bioretention/Rain Gardens.
This workshop addresses NPDES MS4 Permit MCM 6 annual training requirements and is open to 40 attendees.
Parma Branch Library, 6996 Powers Boulevard, Parma, Ohio 44129, April 12th 9:30 AM – 12:00 PM
In collaboration with our regional partners, the Cuyahoga SWCD is offering a short free training module for your staff and contractors involved in the maintenance and inspection of municipal stormwater control measures (SCM's).
As land is redeveloped in the region, the implementation of better SCM's will benefit both residents and businesses. This training program will ensure that your personnel are trained to inspect and maintain needed for the long-term function and effectiveness of your stormwater control measures.
The training will not exceed two hours and will be held on April 12th from 9:30 AM-12:30 PM at the Parma Branch Library. The course will be taught by Elizabeth Hiser, Natural Resources Coordinator from Cuyahoga SWCD, and is custom designed to address common questions on existing and future Cuyahoga County sites. The training module will focus on bioretention.
Please note that the content of this workshop has been reviewed by Ohio EPA to ensure this training satisfies municipal stormwater permit requirements for Minimum Control Measure 6 (Pollution Prevention/Good Housekeeping). As an operator of a regulated small municipal separate storm sewer system (MS4), MS4s are required to conduct employee training on stormwater pollution prevention practices at least once per year.
April 12th - Class at Parma Branch Library, 6996 Powers Boulevard
9:30 AM – Welcome and Introduction
9:35 AM – Intro and Pre-Training evaluation
9:50 AM – Bioretention Maintenance
10:10 AM – Trees as SCMs and Tree Care Presentation
10:35 AM – Post-training evaluation
10:40 AM – 11:20 PM South Euclid Branch Library 1876 S Green Rd
Optional 11:30 AM – 12:00 PM Parma Snow Branch Library Site Visit, 2121 Snow Road


text: According to Ko Wen-je, since the MRT commenced operation in 1996, the historical record of the 10 billionth trip was set on March 31 this year after 23 years of progress, marking an important milestone in the history of Taiwan. He also mentioned that after the Executive Yuan approved the preliminary network of Taipei's mass transit system in 1986, the incumbent mayor at the time Hsu Shui-te formed the preparatory office. Subsequently, with insistence from Mayor Huang Ta-chou, all 6 Taipei MRT lines were opened at the same time, increasing daily ridership from 40,000 passengers to 2.1 million passengers, demonstrating significant growth. Ko also mentioned that all great endeavors or enterprises must embrace obstacles and challenges from the start, and the same applies to the MRT, which experienced accidents such as fire and tire punctures on the Muzha Line. However, thanks to the forerunners at Taipei Rapid Transit Corporation (TRTC), all these difficulties have been overcome, culminating in the tremendous accomplishment of today. The mayor commented that the MRT is something Taipei can be proud of on the world stage, with cleanliness, orderliness, courtesy all becoming an integral part of the Taipei Metro culture. Those who have boarded subways overseas will appreciate the effort that goes into upholding such MRT culture after 23 years. This means that the ethical standards of our citizens have been elevated to a respectable level; he also taunted himself that he was once reprimanded by a passenger for not waiting in line. Mayor Ko shared with the audience the latest progress of Taipei Metro: the Circular Line Phase 1 is slated for operation by the end of this year; while Wanda Line and Xinyi Eastern Extension are currently under construction. In particular, the city government perceives Taipei Metro as the forerunner of Taipei Smart City, where digitization, unmanned stores, logistics, smart locker, and the 5G system will be implemented throughout MRT system. However, Ko also pointed out that several flaws of the metro system are currently being rectified. The first being the Transit Oriented Development (TOD); when planning the MRT network in the early phases, the spirit of urban planning was not incorporated, hence in order to resolve this issue, the city government has carried out a restructuring of all 40 MRT stations in accordance with the urban planning. In other words, the MRT network must be considered as a primary form of transportation, with urban planning designed around the network. Consequently, the TOD urban design guideline for the 40 stations will be announced this year by Taipei City Government. Secondly is the aspect of commercialization. According to Ko, the MRT ticket price has not been increased over the last 23 years, and it had become an extreme burden when he assumed office. Consequently, it is imperative to think of ways to increase non-operating income in order to prevent ticketing pressure. He pointed out using Hong Kong's MTR as an example that the revenue of Taipei Metro relies too heavily on ticketing, as Hong Kong's MTR generates the bulk of its revenue from real estate and shopping centers, this is something that Taipei's metro system is lacking. Therefore, he hopes that TRTC can focus more on non-operating income in addition to its core transport business. He commended TRTC for demonstrating exceptional growth in non-operating income over the last 4 years. Currently, the MRT Shilin Station is used as the test subject; with the goal of commercialization, TRTC will strive to increase non-operating income (property management). The next involves industrialization; the mayor indicated that it is a pity that Taiwan has not created its own rail industry since the advent of the Taipei Metro network, hence he appealed to the Ministry of Transportation and Communications to contemplate how to establish Taiwan's own rail industry. Last but not least is the characterization of MRT stations. According to the mayor, TRTC currently operates 117 stations, but only MRT Jiantan Station features a unique design. He believed that if Taipei Metro is to start all over again, he will make sure that each station sports a distinctive design that is representative of the local culture and characteristics. In order to resolve this problem in the future, several stations will be chosen every year to receive artistic makeovers or seek sponsorship from enterprises in order to beautify the MRT stations. Ko Wen-je emphasized that despite all of the abovementioned problems, reaching the 10 billionth trip is a remarkable achievement of Taipei's metro system. He expressed his gratitude to the endeavors of MRT veterans before him in transforming Taipei into a culturally advanced metropolis of the world. Thereafter, Ko Wen-je presented the Best CEO Award to the President of Taipei Rapid Transit Corporation B.C. Yen in thanking him for his contributions to Taipei Metro over the last 4 years.