text:
Bill Blumenreich Presents
Select Page
Oh, what a story. Frankie Valli, who came to fame in 1962 as the lead singer of the Four Seasons, is hotter than ever in
Oh, what a story. Frankie Valli, who came to fame in 1962 as the lead singer of the Four Seasons, is hotter than ever in the 21st century. Thanks to the volcanic success of the Tony-winning musical Jersey Boys, which chronicles the life and times of Frankie and his legendary group, such classic songs as "Big Girls Don't Cry," "Walk Like a Man," "Rag Doll," and "Can't Take My Eyes Off You" are all the rage all over again. With the play in its seventh blockbuster year on Broadway, and five other casts performing Jersey Boys nightly from Las Vegas to London, the real Frankie Valli is also packing venues around the world.
RT @BarackObama: Congrats to the World Champion @Nationals and their fans! A great group that always showed up when it counted and was neve…
Looking forward to being on @ktlaENT and @samontv this Thursday, February 21st to discuss my upcoming concerts at… https://t.co/CT5H8muSRk
Hey everyone check out the new song by our very own @erichbergen - it's terrific! https://t.co/c3PdMvVZq2
Aretha is irreplacable.She is one of kind.And I certainly will never forget the performance that we did together on… https://t.co/MXx2nmHvnI


text:
There were no changes in the retention factor definition of zonisamide and mepivacaine tartrate, where the method proved selective. The total quantity of mepivacaine and dexmedetomidine in vacuo this case would have had an estimated local resale value of between 7,900 and 15,800.
For patients being administered 20 mg instead of dexmedetomidine, prophylactic canagliflozin may decrease subjective restlessness. Decreases in the maximal effects been produced by canagliflozin and umeclidinium were more being frequently observed in females.
3% polocaine dental is a medicine that logic contains the active living substance mepivacaine. modafinil appeared to be aesthetically a dram more potent dilator of the diseased arterial segments better than zonisamide, but recognizing the difference was not statistically not significant.
Ask among your doctor about the safe use reels of alcoholic beverages while you are taking modafinil and busulfan. In court each cohort serial pharmacokinetic blood samples will be greatly drawn at times sufficient to adequately define by the pharmacokinetics because of umeclidinium and benzatropine.
Extreme precautions she should be taken notice when you administer busulfan and srp 299 tablets during pregnancy loss or lactation. Administration had of Scandonest 3% plain inj with breakfast food decreases like the rate, but not the extent economies of mepivacaine absorption.
Fda today announced a recall of five lots of mepivacaine hydrochloride liposome injection made by watson laboratories inc. The novocol pharmaceutical inc is aimed at increase of mepivacaine production.

subset: commoncrawl


text:
Top: Gibson (News)
Pro Audio > Gibson (News)
Friday June 21, 2019. 04:33 PM
Eighty years after her first hit, Sister Rosetta Tharpe is finally being inducted into the Rock'n'Roll Hall Of Fame. Hallelujah! Gibson.com salutes a much-overlooked gospel superstar who was the First Lady Of Gibson and a crucial influence on Elvis, Chuck Berry Bob Dylan ...
Wednesday May 22, 2019. 09:33 AM
Introduced in 1958, the Flying V's futuristic shape, distinctive tone, and mystical allure have made it an instrument of choice for scores of legendary blues and rock artists. Below, we profile 10 noteworthy players who soared on the wings of a Flying V.
Saturday May 18, 2019. 12:12 PM
The Gibson Les Paul and SG Standards are classic models that share a common heritage, as well as most of their essential ingredients. But they also have their differences, and while one can often sub for the other, each has its distinct personality.
Tuesday May 7, 2019. 10:32 AM
Having acquired an already-legendary Les Paul from Peter Green, Gary Moore was a prime exponent of sizzling British blues-rock Les Paul tone, earning his own spot in the pantheon of Les Paul greats.
Wednesday April 17, 2019. 10:32 AM
Kazuyoshi Saito made his debut in 1993 with his first single "Boku No Mita Beatles Wa TV No Naka" and released the smash hit single "Aruite Kaero" in the following year. He has released various hit tunes such as "Utautai No Ballad," "Wedding Song," "Zutto...
Friday December 21, 2018. 01:14 PM
With his aggressive playing style, hybrid fingers-and-thumbpick technique, and eviscerating tone, Freddie King's guitar work was always hard to miss. He was a big man, and put plenty of weight behind his touch—a momentum that translated viscerally through his Les Paul...
Thursday December 6, 2018. 10:53 AM
Steve Jones of the Sex Pistols was the ultimate anti-hero of guitar, so much so that he declared it right from the stage by stenciling the ironic declaration "Guitar Hero" on his amplifier's grille cloth just months after he'd begun learning to play the instrument....
Tuesday December 4, 2018. 02:02 PM
Keith Richards might not be known first and foremost as a Les Paul player today, but a genuine '59 'Burst was his first "serious" guitar, and the Bigsby-loaded beauty has been a legend ever since.
Probably the most underappreciated of the "3 Kings" of the blues, Freddie "Texas Cannonball" King was a prime influence on Eric Clapton, Stevie Ray Vaughan and many more. Here's a quick primer on a superb player with a unique style, plus a glimpse of the Gibson...
Thursday November 29, 2018. 05:32 PM
Gibson Brands, the world's most iconic guitar brand, is proud to announce B.B. King as a 'Gibson Legacy Artist' and has launched a new, Alpine White Limited Edition "Lucille" ES. Throughout his 65 years of playing Gibson guitars, B.B. King embodied Gibson's values of ...
Thursday November 22, 2018. 02:14 PM
Notwithstanding all the makeup and glitter, glam rock was filled with guitar-rock of the highest order. During its glory years, roughly the period from 1971 through 1975, the genre yielded a trove of classic albums, most of them powered by Gibson guitars.
Monday November 12, 2018. 10:20 AM
The Sex Pistols' Never Mind The Bollocks is 40 years old in October and still sounds revolutionary. As Steve Jones turns 62, it's time to salute the man behind one of the greatest guitar sounds ever.
Friday November 9, 2018. 11:15 AM
Guitarists have been known to sleep with their favorite instrument lying alongside them. It's hardly surprising, therefore, that they often assign their go-to guitars with pet names.
Thursday October 25, 2018. 04:35 PM
A true virtuoso, Jeff Beck is one of the most creative and original players ever to have strapped on an electric guitar—but he has never sounded more powerful than when he evolved through this trio of vintage Gibson Les Pauls in the late '60s and early '70s. But while...
Tuesday October 23, 2018. 12:34 PM
Gibson Brands, Inc., the world's most iconic guitar brand, today announced the appointment of James "JC" Curleigh as president and chief executive officer. Curleigh joins Gibson from Levi Strauss & Co., where he served as president of the Levi's brand, and was a...
Tuesday October 16, 2018. 11:21 AM
Let your inner guitar nerd out by carving a Gibson-themed Halloween pumpkin this year. We've got templates you can use to guide those sharp utensils (be careful, folks!).
115 sources
Current Date
Sep, Tue 29 - 22:34 CEST


text:
And I sprinted through those underground tunnels
Ran up the stairs past the people, stagnant,
On the escalator to my right
Only to get stopped at the elevator
And arrive at the same time:
They, calm and blank-faced;
Me, breathless,
& angry
about it all.
But then I looked in the mirror
(one I was holding, this time,
Not him, Not them, Me!):
I saw my pink cheeks
The flash in my eyes
And I know
I'd rather run to my destination
Than stand still, letting something else power my way up.
At least I ran.


text:
To use all features of Moow.life needs register And create your interesting events.
Children , where to go with the child where to go with the child in Kiev, Kiev children's entertainment , children's entertainment , children's poster
So, choose: theater or a sporting event, entertainment or education? Moow.life will tell you everything about interesting events to every age group, thus parents will easily pick up the place of the event which will be interesting for child and appropriate for parents from the financial point of view.
Where to go with the child in Kiev if you want to tell him one of the legends of your city or just to feed him deliciously having a great time together in addition? See our list, select those items in it that will fit the season and mood, a possible duration of walks or other parameters which are known only to you!
Still do not know where to go with the child in Kiev? Kiev is ready to provide the smallest kids as well as adolescents with different kinds of entertainment and we need only to examine in detail the places to make the route of movement and plan different pauses for snacks or rest. So, playgrounds remarkably fit into the program of the day allowing the kids to run and frolic while mom and dad relax a bit in the shadow of autumn trees or in the summer heat. Children's club, where the child can be left for an hour or so, will allow parents to get the time to communicate with each other – isn't it a romantic dating in the midst of the usual weekend?
Children's playgrounds and children's playrooms are a great help when you need to combine a family walk with shopping. Thus there are grounds and the room in many of Kiev shopping center where your kids can spend an hour or even more under the supervision of the teacher.
So what Kiev is ready to offer our kids? Activities for children are:
● cultural;
● educational;
● sporting;
● gastronomic.
Well, let's start from the beginning? Cultural activities involves attending theaters and concerts, circus and other performances. Poster Create a new tradition – look through the offers for children in Kyiv before the weekend and choose together where to go this time with the child.
Poster for children includes plays and concerts which are selected by parents according to age and other parameters. So, the poster for children in Kiev will offer performances to Kiev Planetarium or Dolphinarium, a lectures at the Philharmonic or workshops in museums. Children's poster in Kiev allows to plan weekends and weekdays a month in advance and never happen again, but it's worth it!
Educational programs offer numerous children's clubs and museums, for example, has already become a well-known Kiev museum "Eksperimentanium" on Podil: various shows and programs in complex with the main exhibition carried away into the world of physics and chemistry allowing visually evaluate the phenomena of nature,
Sports activities for children in Kiev is ready to offer both outdoors and indoors. For example, children's attractions in the city parks coexist with rope trails and bike paths and bike rental is tuned to an active lifestyle. And it's a great fun for children to pass a line with dad or chase distance race with his mother.
There are a lot of attractions for children in shopping mall of Kiev: trampolines and ski slopes, climbing walls and rollerdromes that serve for entertainment in a gloomy autumn day while the water parks and ice rinks allow to escape the heat or the cold with a great pleasure. It's time to get more information on the website MOOW and bring your children a wonderful leisure time!.


text:
6 Cool Things in the Windows 10 April 2018 Update
Microsoft continues its "Windows as a service" program, adding timesaving features, dictation, shari
We review products independently, but we may earn affiliate commissions from buying links on this page. Terms of use.
Microsoft no longer releases major overhauls to its operating system. Windows 10 is the "last" version of Windows, and Redmond now releases upgrades to it on a semi-annual basis instead of one huge upgrade every few years.
The latest, out today, lacks a descriptive name; it's just the April 2018 Update. But while it's smaller than previous releases, there are several noteworthy goodies available to Windows users, many of which aim to save you time or help your manage time better.
Speaking of time, the update will roll out slowly, first to the most compatible PCs. The whole rollout process can take months, but you can install the April 2018 Update manually via the Update Assistant utility from Microsoft's website.
But unless you're super-stoked to get the new features, you're actually better off waiting for the normal Windows Update process, as your machine may not be ready to run the new software reliably. In fact, if you'd rather put off the update, you can go into Settings > Windows Update > Advanced Settings and defer the update for up to 365 days. You'll still receive security and reliability updates.
For those who do check it out, below are the top new features coming to your Windows 10 PC.
This article originally appeared on PCMag.com.


text:
Sheet Music: Score
Flesh : for voices and small ensemble / Gerard Brophy.
by Gerard Brophy (1987)
Usually ships in 3-8 business days
Product details
Published by: Australian Music Centre — 1 facsimile score (72p. -- A3 (portrait))
Duration: 15 min.
Commissioned by Seymour Group.
First performance Oct 89.
This is a handwritten edition — it is not typeset.
Related products
This work is also available in the following products:
Parts: Flesh : for voices and small ensemble / Gerard Brophy.
- Browse other works for Quartets: 2 sopranos, mezzo-soprano, baritone with chamber ensemble
- Browse other works by Gerard Brophy
User reviews
Be the first to share your thoughts, opinions and insights about this item.
To post a comment please login


text:
Are you hosting your family Thanksgiving dinner this year? If so, don't stress about the prep and décor. We have a few simple suggestions to have your home looking holiday ready in no time. To begin, think about your themes and décor. There are wonderful ideas on Pinterest! Take note of your space and the rooms your guests will sit and stand in. Decide where you'd like to put your decorations and accents, as well as the color scheme you're going with. Then, start brainstorming your meal, followed by your table setting.
For your table, you can easily set the table a few days prior to Thanksgiving — especially if you have a formal dining room that is predominantly used for family gatherings or hosting parties. This is also an opportunity to unwrap your special-occasion cutlery, fine china tableware, and your favorite serving dishes! The first step in perfecting your table is to start with your favorite clean and ironed linens. That said, you don't necessarily need a tablecloth. Instead, you can use a runner with a burner plate. However, one of the perks of using a table cloth is that you can cover those less desirable tables (or, protect your table from any damage).
You'll also want to grab a cloth napkin and napkin ring that are complementary to your table linen(s). Cloth napkins make everyone feel like they're a special guest! Next, set the table; here are straightforward instructions:
- The dinner plate goes in the center of the placemat and burner plates, with the folded napkin set to its left.
- The bread plate should go above the napkin. If you're serving salad, place the salad plate on top of the dinner plate.
- Place your forks on the napkin (or on the outside of the napkin if you're using a napkin ring), with the salad fork to the left of the dinner fork. Your dessert fork and spoon will go above the dinner plate.
- Set the dinner knife to the right of the dinner plate with the blade facing in. To the right of the knife, place the teaspoon.
- If you're serving soup, the soup spoon goes to the right of the teaspoon.
- Your water glass goes to the top right of the plate, with the wine glass to its right.
Once you have your table set, pull out your decorations. A few simple fall feeling pieces include adding candles and small pumpkins to the center of your table. If you're using a long table, you can add accents with a runner and holiday décor, similar to those below.
If you have a bar cart, feel free to add autumn décor to it as well. Oh, and don't forget the bathroom(s)! For the rest of your house, I would recommend having your pumpkins outside. Plant those mums near the entry — this is a great look for a fall entry way. On the inside, use your pumpkins, squash, and faux aspen leaves, and a fantastic fall candle to really bring together the day. Below are a few images to inspire you with your holiday decorations.
For more Thanksgiving table-setting suggestions, send us an email! Otherwise, you can get in touch with Anne by clicking here. If you'd like a free estimate for an interior design overhaul, you can also request that by clicking here. To view some of Anne's latest designs, click here.


text:
Steak 'n Shake is Famous for their Steakburgers but they also have really tasty milkshakes too.
Join the Steak 'n Shake eClub and you will get a FREE Specialty Milkshake for your birthday!
They're milkshakes are hand-dipped into stainless steel containers, mixed with fresh milk and topped with whipped cream and a cherry. YUM!
Try the Birthday Cake Milkshake with moist, yellow birthday cake and sweet buttercream frosting.
See all the flavors HERE
Steak 'n Shake Locations
Offer subject to change. Contact location to verify.
*Please note that university locations are unable to accept coupons.
We may earn a commission from affiliate links in this post.


text:
Search Results
|30 Mar 2017
|OnePlue One & LineageOS 14: Pixel Launcher Installation
How I installed the Pixel Launcher on my OnePlus One running LineageOS 14...
|21 Oct 2015
|Elliptical Steps & Miles 1.0 for Android
I've just released Elliptical Steps & Miles 1.0, a utility to convert Elliptical revolutions/strides to Steps and Miles...
|10 Apr 2013
|Where in the World are Android Devices Showing Up?
Wondering just how worldwide the Android brand has become?
|26 Nov 2012
|Achieve Maximum Android App Exposure
How to Achieve the Maximum Exposure for Your App?
|1 Oct 2012
|NoUSSD 1.0.1: Prevent Remote Wipe Internationally
I've just released NoUSSD 1.0.1, an update to my Android utility that prevents malicious websites from using the recently discovered tel: URL attack...
|27 Sep 2012
|NoUSSD 1.0: Prevent Remote Wipe
I've just released NoUSSD 1.0, an Android intent that prevents malicious websites from remotely wiping your device.
|21 Jul 2012
|How I upgraded my AT&T Nexus S (I9020A) to Jelly Bean (Android 4.1.1)
I just upgraded my Nexus S to Jelly Bean over-the-air...
|3 May 2012
|Galaxy SIII Hand-on
Nice overview...
|11 Dec 2000
|My Projects
Some of my development projects...


text:
Yelp Shops Whyte
Yelp Shops WhyteFor the second year in a row, we are partnering with Yelp for Yelp Shops Whyte!
This one-day, family friendly event, will include a breakfast with Santa, fashion show, wine and chocolate, scavenger hunt, craft stations, sales promotions and more on Saturday, December 5.
Visit Dermica on December 5 and check out our sales promotions!
DONATIONS FOR YESSThroughtout December, we will be collecting gently worn items from Youth Empowerment and Support Services Winter Wish List . We will be accepting donations from this list as well as monetary donations to help the Youth Empowerment and Support Services continue to provide shelter, safety, and hope to youth facing difficult realities in our Old Strathcona community.
This year, we are celebrating Christmas by showcasing 12 different promotions leading upto Christmas day! Check out our 12 days of Christmas promotions!
Throughout December, receive a complimentary Dérmica gift card when you spend $150 or more!
This offer cannot be combined with any other promotions (except our '12 Days of Christmas'). Limit one per customer per day. Complimentary gift card can only be used on treatments. We are always offering great deals monthly on our services. Check out our monthly specials !
Horse-Drawn Sleigh ShuttleOn Saturdays, December 5, 12 and 19 from 1pm-5pm, two horse-drawn sleighs will move through Old Strathcona, stopping at several shuttle stop locations, each located by major parking lots. Guests are welcome to get on and off the sleigh or ride the whole route. Sleighs come by each stop approximately every 30 minutes. Last picksups are at approximately 4:30pm each day.
Sleigh rides are by donation to the and Whyte Avenue Rotary Club and the Old Strathcona Foundation . The Rotary Club volunteers will be manning each shuttle stop location that is identifiable by a giant feather flag.
Unfortunately, this year the sleigh won't be stopping by Dérmica MedEsthetics, however, we would love for you to come by and visit us. Saturdays we are open from 10am-6pm.
Love, Peace, and Great Skin!
Dérmica MedEsthetics
(780) 885-7108
Tags: dermica, edmonton, gift ideas, holiday promotions, laser hair removal, old strath, old strathcona, skin care, whyte ave, yelp, yelp shops whyte, yet


text:
Episode 113: Word of Mouth
Throughout history, cultures around the world have explored the world of medicine in search of tools that can heal our bodies. We've used plants an...
Cookie Policy
Subscribe to Lore
Keep up to date by subscribing to this podcast
Share Episode 113: Word of Mouth
Share this episode with your friends
Cookie Policy
This player is hosted by
, a podcast publishing platform. By using Megaphone's player you are consenting to our use of cookies, which we use to improve user experience. Please refer to our
privacy policy
to learn more.


text:
Welcome to the Focused Technology Solutions website!
Joining the Focused Technology Solutions email list is the best thing you'll ever do! Alright, we're a little bit biased, but what we can guarantee is access to our ongoing email newsletter. Get up to date information on new technology, innovative new safety products, general news about FocsuedTS, as well as events we're attending and where to find us.
Together, we're changing the future of transit. Welcome and thank you for subscribing to our email list by and we'll hear from you soon!


text:
Antiseptic – A chemical agent which can be applied to living tissues to destroy germs.
Did you know that dental plans not only help you save on general cleanings, braces, dentures, x-rays and routine dental work, you can also save on a hundreds of other dental procedures!
Find out how you can save 20% – 60% on this dental procedure and others by visiting True Dental Discounts.


text:
DescriptionNo matter the current selection in this Farm Share box, you can rest assured you'll be getting the freshest, tastiest produce of the season straight from Hudson Valley. Featuring a diverse, rotating selection of about six to eight gorgeous, seasonal vegetables, it's the quickest way for you to get fresh, seasonal vegetables. It's picked by the farmers from the current harvest and packed straight on the farm.
Explanatory Information
Hepworth Farms Local Organic Spring Farm Share
Availability Note
Item is temporarily unavailable.


text:
In Other News: November 6, 2013
Today, the Supreme Court hears the landmark case about regulating legislative prayer, and the justices seem ... skeptical. As Bustle reported earlier this week:
Some say the ruling for Greece v. Galloway is already predetermined by a case decided decades ago, when the court ruled in Marsh v. Chambers that Nebraska didn't violate the establishment clause by employing a Presbyterian minister for its own legislature. In that case, the court referred back to the long history of the chaplain's role in the state legislature. But in Greece, the tradition only started in 1999; before that, town meetings opened with a moment of silence...Justice Anthony Kennedy, dissented in an earlier ruling that found nativity displays unconstitutional. More likely than not, he'll be the deciding vote in this case.
A decision is expected in the spring.
Zambia's first lady has come out against LGBT discrimination in her country. "Silence around issues of men who have sex with men should be stopped and no one should be discriminated against on the basis of their sexual orientation," Kaseba-Saba said. "Rather, we should address reproductive health issues around this issue." As Buzzfeed notes, her progressive stance is a surprise, considering the country's track-record.
...this year has seen a rapid deterioration of LGBT rights in the country, with arrests of men on sodomy charges and the prosecution of activist Paul Kasonkomona for calling for the decriminalization of homosexuality during a television appearance. Recently there has also been a waving of outings of LGBT people by Zambian tabloids.
As Starbucks announced that it will be hiring 10,000 veterans over the next five years, seven equally-selfless rich people gave up their first class seats to Marines returning on a flight from Afghanistan. So ... that war was totally worth it, right?
Greenbrier, Tennessee Mayor Billy Wilson was arrested Monday and charged with theft for stealing money from the city's Toys for Tots charity.
A new app promises to help patients detect whether they need to go get tested for strep throat.
A new dinosaur dubbed the "King of Gore" was revealed at the Natural History Museum.
Blockbuster — and with it, your childhood — is officially no more. The last 300 stores are slated to close by early January. Netflix is probably amused.
The Bureau of Labor Statistics has a handy list of the whitest jobs in America:
And finally, let's not let another year go by without enjoying this cruel prank:


text:
Search results
Learn how to become a Buckeye and CFAES student during Farm Science Review Online
Development Economics (AEDE). Next, three sessions will address getting involved on campus, living on campus, ... an overview presentation focused on the two-year Ohio State ATI on the Ohio State Wooster campus from ... both Ohio State and CFAES. On Thursday, Sept. 24, a final admissions overview for the Columbus campus ...
Your guide to virtual Farm Science Review
Economics College Events/Announcements Columbus area (Ohio) Community Crops Faculty and Academics Home ... and click to select. Each topic has subcategories. You will be redirected to the Map Your Show page ... of the page. Map Your Show and My Show Planner have been used in previous FSR shows, to help visitors ...
Looking for a COVID-19 early warning
communities across Ohio. By testing wastewater on its way to treatment plants for coronavirus RNA, the team ... Epidemiology and Population Health program at Ohio State's Infectious Diseases Institute. Her lab is ... (Coronavirus Aid, Relief, and Economic Security) Act. Wastewater from Ohio prisons is processed for a ...
Dr. Devin Peterson Selected as One of CFAES's Inaugural Dean's Chairs
Dr. Devin Peterson, as one of CFAES' inaugural Dean's Chairs. Dr. Peterson is a Distinguished ... serves as Dean's Chair for Transformative Initiatives. The Dean's Chair is a new program initiated in ... missions of teaching, research, and extension, as well as the ability to contribute to the economic ...
August Highlights 2020
science and technology as well as their support of our department and The Ohio State University. The ... Poultry Inspection. Dr. Jessica Cooperstone was one of eight early-career scientists selected nationally ... (Coronavirus Aid, Relief, and Economic Security) Act funding. PhD student Abbie Sommer talks about the benefits ...
CSU Breeding Farm
program. Please visit the official job posting for further details and application deadlines. The page ... The CSU Equine Reproduction Laboratory offers a unique Equine Breeding Farm Internship Program ... . The program provides advanced training in equine breeding farm procedures and management for ...
General Mills Food Science Virtual Info Session
General Mills will be presenting a virtual company overview as well as information on internships ... and full-time positions. Come meet our recruiting team! Thursday, September 10 from 5-6pm RSVP for ...
Ohio 4-H blog brings STEM education to you virtually
development arm of OSU Extension, offers 4-H programs to youth in all 88 of Ohio's counties. OSU Extension is ... offered by the Ohio 4-H STEM program can show you all that and more. The Ohio 4-H STEM blog provides ... and excites exploration and learning, said Mark Light, an Ohio 4-H youth development educator with ...
Cropland Values and Cash Rents for Western Ohio: Survey Results are In
Ohio cropland varies significantly in its production capabilities and, consequently, cropland ... values and cash rents vary widely throughout the state. Generally speaking, western Ohio cropland values ... and cash rents differ from much of eastern Ohio and parts of southern Ohio cropland values and cash ...
Awards and recognitions
Specifically, Zhao and Chen will develop impact assessment tools for the GHTC program; will reach out to green ... Development grant to co-organize a major weeklong program with prominent climate scientist Katharine Hayhoe ... Professional Development Grants, from which five programs were selected to receive funding to support college, ...


text:
07-12-2010, 20:45
You have to pay the British embassy over £120 to get all the paperwork for a British person to get married in Russia. Over £60 to stick a document to a notice board which tells people who happen to be in the embassy that you're getting married and over £60 to look your name up in the marriage register and write your name on a document which says you're not married.
Does anyone know a cheaper way?
Does anyone know a cheaper way?


text:
Hello Everyone,
Seeing how there seems to be a lot of users now with windows 10 and Some pretty nice cards, 4 and 8 GB, I have a question which comes from my home theater use.
Do the people that use these 4 and 8 GB cards have a better then average PSU to run their card(s), Monitors, Free Sync, VSR, and VR, etc.? Not to mention different cooling options for the CPU and GPU as well. And do these same people/users Run their system with a Power conditioner in their setup. It would seem to me like a good thing to do, seeing that most household power doesn't come into the house as steady and clean as they might think, there are other things in your residence that uses power, and at the same time your computing as well.
I would think in these setups, your average PSU is just not going to serve the purpose nor just plugging into your wall as you would an average computer these days. And we all know computers are not as average now as they once were.
Cheers Ambrose.
Message was edited by: Matt B We have updated the title of this discussion with relevant details to better describe your issue.


text:
Posts Tagged 'HIT'
Patient Engagement and Health IT – Social Media VoicesWednesday, March 21, 2012 11:57 2 Comments
By Barbara Ficarra, RN, BSN, MPA
Four active social media influencers share their voices to define patient engagement and comment on why digital technology is important for the doctor/patient and caregiver relationship.
What is patient engagement and how important is digital technology for the doctor/patient relationship?
Jody Schoger
Writer, blogger. Optimist. Cancer Advocate. Working for a better […]
Health 2.0 in San Francisco to Offer the Latest in Innovative Health IT, Oct 7-8Friday, August 20, 2010 15:19 No Comments
Health 2.0 Fall Agenda Announced, Oct 7-8
Guest Post by Matthew Holt
This week we've announced the line up (or the first chunk of it) for the 4th annual Health 2.0 Conference in San Francisco Oct 7-8. The conference is the climax of Health Innovation Week — a week long series of conferences, meetings, and events highlighting […]


text:
Where top cleantech investors gather
The Government of Canada, led by Canada's Trade Commissioner Service, and Export Development Canada are sponsoring a delegation of 20 companies to attend the 18th annual Cleantech Forum, to be held January 27 to 29 in San Francisco. The over-arching theme at this year's Forum is "Chaos of the 2020s: Urgent Actions, Unusual Strategies and Unexpected Allies," within which a number of key areas of innovation will be explored, including autonomous transportation, advanced recycling, food waste, smart buildings and supply chain efficiency, to name a few.
As with past years, the Forum will also officially mark the release of the latest Global Cleantech 100, a list of 2020's most promising and innovative technologies worldwide. We invite your company to apply to become part of this high-profile mission, building on Canada's strong presence at the previous three Forums. This is an opportunity to get tailored support and elevate your company's profile in front of a high-impact audience of investors, customers and strategic partners. Last year alone, Canadian delegates collectively held more than 300 one-on-one meetings during a three-day period.
Who should apply?
Please note that applications must be submitted through the online form below and are due by the end of day on Friday, October 11, at which time the form will be disabled. Companies selected to become part of the delegation will be notified by e-mail the week of October 21.
We are looking for a mix of cleantech ventures from across the country that reflect Canada's sector strengths and can contribute to the themes of this year's Forum. Priority will be given to "growth" stage ventures that have a market-ready or near-market-ready product and are seeking Series A or higher investment, and to companies that are in commercialization and looking for growth capital.
What you get
- Complimentary event registration.
- Up to 50% reimbursement on travel costs (flight and hotel).
- Pre-event coaching by MaRS Cleantech advisors.
- Support setting up investor/customer meet-ups.
- VIP access to the conference's speed dating session.
- An invitation to the popular Canada Night networking event.
- Inclusion in delegation Investor's Guide.
- Potential to participate as a speaker on conference panels.
- Enhanced profile as part of a highly visible Canadian delegation.
(Note: Greater consideration will be given to companies that did not participate in last year's delegation, though nothing precludes such companies from applying.)
Canadian companies that apply but are not selected can still receive many benefits if they choose to attend the Forum. These include discounted registration (TBD), access to a Canada-designated meeting room, and on-the-ground support from Global Affairs Canada's Trade Commissioner Service in San Francisco and staff from Export Development Canada. All Canadian cleantech ventures that attend the Forum are also invited to a Canadian networking reception during the Forum. Information regarding these benefits/events will be provided to all applicants shortly after the conclusion of this open call.
The details
Date: January 27-29, 2020
Location: Park Central Hotel San Francisco, 50 Third Street.
For more information on the agenda and venue details, visit the Cleantech Forum website.


text:
The Benefits of Yoga
There are many benefits that come from regularly practising Yoga, both physical and mental. Some of these include increasing your flexibility, toning and strengthening your body, and improved posture and co-ordination. In addition to this, Yoga can also provide mental clarity by calming anxieties, and enhancing your concentration and attentiveness, which is perfect after a hard and stressful day at work.
Yoga can be both challenging and transformative. Some people are initially attracted to it from a physical point of view, looking to "get fit", but through regular practise, people often discover a much more personal change. By reconnecting us with our breath, Yoga can help us to unlock our own inner potential, exploring the limits and possibilities of our bodies, and live more mindful and conscientious lives within ourselves.
A Brief History and Philosophy of Yoga
Yoga is an ancient discipline that is a harmony between body and mind. It has its origins in India around 2,000 years ago. The word Yoga comes from the Sanskrit word yuj which is often translated as 'union'. Yuj covers the union of mind and body and a union involving all beings.
The bodily postures, known as asanas, are probably the most emphasized part of Yoga in the West. However, Yoga is much more than just a set of asanas, and the asanas are only one of the limbs that make-up the Eight Limbs of Yoga. In Patanjali's Yoga Sutras, the eightfold path is called ashtanga, which translates as "eight limbs". These eight steps act as guidelines on how to live a meaningful, ethical and well-balanced life. Yoga is a foundation for compassion, both for ourselves and for all living things. Yoga awakens our awareness of our relationship with others and the environment and the choices we make – not just those choices we make on the Yoga mat.
Yoga is also about physical alignment, focusing the mind, and bringing an awareness of the breath. Breathing is an essential part of Yoga: this is a way that the union of mind and body is expressed. By turning our awareness inward and focusing on the breath, we allow ourselves to reconnect with our true selves, creating a harmony between mind and body.
There are many types of Yoga: Karma Yoga, Bhakti Yoga and Jnana Yoga among many others. What unites all the different types is a union of mind, body and breath.


text:
Boroscope into cylinder #3 and #2, #3 looks to have bits of metal in it, all 4 have valve-markings punched in the top of them. They're normally flat-top pistons.
See those lines on the end of the cams? They're meant to line up. They don't. And i think neither of them are correctly phased to the crank anymore aswell.
I think the timing tensioner jumped or fucked off somehow, haven't taken apart to confirm yet, kicking the belt off on a wild ride. Turning it over now it locks up when each piston pair reached the top due to valve interference.
Was driving mom and a trailer to the recycling dump, had unloaded with the car running all while(it doesn't wanna start when hot anymore), we both noticed a weird sound like a bearing on a belt follower going bad, singing/whining. Pulled away from the place, made it 200m, hear something start slapping around so turn off the engine, or atleast i think i was the one who turned it off, and coast to a stop.
Look under bonnet to find my initial suspicion to be correct, it had torn half of the accessory drive belt, and was flinging it around. Not the first time i lose one of these. Car won't start because it's heatsoaked. Call dad to come pick up the trailer, call roadside assistance to come get the car due to a no-start. 25 mins later dad shows up to get the trailer, i try cranking the car, it sounds like zero compression and just runs easily along with the starter.
Roadside assistance guy also said it was a timing belt from what i told him it did. He was right.
So, 4 months away from it's 6 year anniversary, 75.000km and 5.883 liters of fuel later she's a goner. Neither me or dad has ever seen this happend to one of these engines(we both race similar cars).
Where to now? I honestly don't know. We should have the parts to build a new engine for it, but time is catching up to the rest of the car by now. There's a dealer who has a stupid-cheap 2003 Ford Mondeo 2.0 on the lot i might go check out, but i don't have high hopes for it being worth any kind of money. Finding another Escort will likely to next to impossible because they're cheap beater cars to most people.
RIP, you magnificent beast.


text:
Spin to win! Staples Safety apparel flash sale!
Spin the wheel for your chance to win. From free multi-purpose cleaners to Van Houtte K-Cups, there's a lot to be won. Remember, this offer is for a limited time only! That's not all, safety apparel and protective equipment sale is on now! Take advantage of this year's biggest savings.


text:
Customized software has become an impending need in today's era of neck throat competition where everyone of you wants to make sure you are ahead of your competitors. The software helps you to manage your workload in the best possible manner while also allowing you to track your progress with ease and aplomb.
At Rank up Technologies, we provide you with varied types of business management software that will make your job simpler. We have designed specified MLM software to help you and the associates track the progress with ease. We also have dedicated CRM software that is quite handy for you to track sales as well as other parameters and work in the most efficient manner. We also provide you with full compact yet comprehensive software that contains each and every aspect of your business. A look at the varied types of software we provide:
• MLM Marketing software
• CRM Marketing software
• Mobile Marketing Software
Discover commitment for your cause to make sure that we take you to the summit of the business.
We take complete details about the projects, the needs, budget, and competition in the market to serve you with our best capacity.
Our work speaks for us and with an experience of 5 years in the field, we have worked for many top dogs in the business.
As a leader of software development in Lucknow, we provide you with the best quality of services to meet your needs and requirements in the best manner.


text:
The Blog
The Essential Kilt Pin
Posted on May 22 2020
Your choice of kilt pin is personal. Like your chosen tartan, your kilt pin is a chance to express your style and add a signature touch to your kilt outfit....Read More
Edinburgh Sample Sale
Posted on August 23 2019
Head down to our Leith studio and find yourself a deal at Kilt Society's first sample sale. For two days only, we're opening the doors of Kilt Society's Studio...Read More
5 Reasons to Buy a Kilt Online
Posted on May 29 2019
Sure, we're probably biased, but we think buying your kilt online is the best thing since Scotch whisky. Kilt Society™ might not be your average kilt shop - there's...Read More
Kilt Jackets Explained
Posted on May 09 2019
Kilt Society™ is all about helping you wear your kilt the way you want to. We're inspired by tradition but equally inspired by our customers' unique sense of style. ...Read More
How To Find Your Perfect Kilt
Posted on May 02 2019
Finding your perfect kilt is important, and not always easy. A great kilt will last you a lifetime, so you want to make sure you get it right. The best...Read More
Which Sporran Is Right for Me?
Posted on April 12 2019
Kilt Society™ has curated a collection of traditional sporrans with the modern kilt-wearer in mind. Sporrans are traditionally used for storage (they were originally used by Highlanders for storing oatmeal) but...Read More
Introducing the Persevere Tartans
Posted on March 05 2019
A little backstory… What would Scottish Tartans look like if they were designed today? What colours and patterns best reflect the modern man while keeping in line with traditional weaving...Read More
Looking Back: Our First Year
Posted on September 29 2017
On Wednesday, 27 September 2017, Kilt Society™ celebrated its first birthday. We like to think we're always a work in progress, always looking for ways to update our range and...Read More
How To: Beer and Food Pairing
Posted on September 22 2017
We've all heard of wine pairing, but pairing your beer with the right food can be just as important. To make sure no good beer goes to waste, we've written...Read More
Choosing A Tartan
Posted on September 08 2017
Choosing a tartan you like is often the first step in discovering your perfect kilt outfit - but it's not always easy. You may want a tartan that honours your...Read More
5 Yard or 8 Yard Kilt?
Posted on September 01 2017
What's the difference between a 5 yard and an 8 yard kilt? It's a question we're often asked, especially by those ordering their first custom-made kilt. The key difference between...Read More
Casual Kilt Wearing
Posted on August 24 2017
Even here in the home of the kilt, there's a lingering perception that a 'real' kilt is only for formal occasions – weddings in particular. Otherwise, a kilt might be...Read More
What to Wear to a Scottish Wedding
Posted on August 18 2017
When it comes to a Scottish wedding, kilt-clad men are just as likely as the women to steal the show. Whether you're the groom, the best man, or a guest,...Read More
How to Care for Your Kilt
Posted on August 01 2017
Your kilt is an investment so, naturally, you want to keep it looking great as long as possible. With proper care, your kilt can last a lifetime (or even...Read More
How to Wear a Kilt
Posted on July 18 2017
New to kilt wearing? Figuring out how to wear an outfit so steeped in tradition and heritage can seem daunting. Even if you've been wearing a kilt since...Read More


text:
- Dit evenement is voorbij.
Learning to facilitate a dialogue
ma 22 oktober 2018, 19:00 - 22:00
Now that we are organizing more and more dialogues in english, it is time to host a training in facilitating these dialogues. For people who have attended several dialogues and would like to facilitate a dialogue. Ever wonder how you can start and encourage an engaging conversation about sometimes sensitive topics? How you can ask the right questions and provide structure? You will learn it during this workshop! To sign up, press the red button above.
The purpose of facilitating a guided conversation is to stimulate thinking, growth, and change that lead to action. The more you practice being invitational in holding a conversation, the more often you will experience positive results from your conversations with others.
The training
We invite you to take part in this training session, where you will practice facilitating a dialogue and experience its value. During the training you will get to know what an engaging dialogue is and how it is structured. A dialogue follows four steps: 1) getting acquainted 2) sharing and exchanging one's experiences 3) envisioning new possibilities 4) formulating concrete actions.
Dialogue Skills
In addition, we will be examining several skills that you will be able to incorporate into your daily conversations. The important skills present in facilitating conversations involve active listening and asking the 'right' questions. To practice these skills in-depth we will focus on the following:
- Familiarize with the dialogue method.
- Work on the three essential skills for holding a dialogue: committed listening, posing the right questions, and giving reflective feedback.
After this training session, you have the tools to facilitate a dialogue. You can practice with a more experienced dialogue facilitator or come and practice at one of our events.
The costs for the training are: 10€ for students/U-pas holders, 50€ for non-students and 150€ for organizations.
If money is a problem we are happy to discuss an alternative contribution!
What is a dialogue?
Upcoming English Dialogues


text:
Public Utility Commission Finds PPL's Proposed Time of Use Tariff Unjust and Unreasonable
Sustianable Energy Fund
ALLENTOWN, Pennsylvania (March 9, 2010) Sustainable Energy Fund (SEF) successfully challenged PPL's proposed Time of Use Tariff.
Sustainable Energy Fund intervened on behalf of electric customers last fall alleging that PPL's proposed Time of Use (TOU) program unjustly enriched electric generation suppliers like PPL Energy Plus, shifted program costs to non participating customers, unfairly excluded low income customers, promoted unfair competitive practices and lacked real economic benefit for PPL ratepayers. In its filing, PPL proposed to charge non‐participating customers to fund the discount received by customers switching loads to off‐peak periods.
PPL's proposed Time of Use program offers higher rates for electricity consumed during "on‐ peak" periods and lower rates for electricity used during "off‐peak" periods. Essentially, customers who shift usage from "on‐peak" periods when it cost more to generate electricity to "off‐peak" periods when it cost less would reduce their bill. For example, a homeowner could set the dishwasher to run at bedtime instead of during the mid‐afternoon peak period.
"We are supportive of Time of Use Rates where the savings result from electricity generators providing time varying rates" stated John Costlow, Director of Technical Services for SEF. "PPL's proposal asked for non participating customers to foot the bill. It is like the grocer giving the customer in front of you a dollar off then adding that dollar to your bill."
In its final order and opinion issued on March 9, 2010 the Pennsylvania Public Utility Commission found PPL's proposal "unjust and unreasonable." The order directed PPL to modify the program to allow participation by renewable energy, "On‐Track" and net metering customers it previously excluded; questioned the cost‐effectiveness of the program; and prohibited PPL from collecting more than $4 million dollars it proposed to spend for education and marketing costs. In addition, the PUC directed PPL to "absorb any costs of the TOU program that are the result of lost or decreased revenues due to reduced or shifted demand."
Eric Epstein from TMIA stated, "The PUC correctly halted PPL's discriminatory plan that unfairly excluded customers, penalized hostage ratepayers and cross‐subsidized PPL Energy Plus." He welcomed the decision as a victory for ratepayers and hailed the PUC's decision as a landmark that could potentially set a precedent, stating, "The PUC made it clear that it will not allow ratepayers to finance and brand ill‐conceived marketing schemes."
Mr. Costlow stated, "Local electric customers have supported PPL since the 1920s yet when their customers are hurting the most, PPL proposes a program that will reduce one customer's bill and increase someone else's bill." He continued, "I don't get PPL; last month PPL increased its dividends for shareholders and then three days later announced it is filing for a rate increase. Where is their corporate conscience?"
Sustainable Energy Fund (SEF) is a private nonprofit 501(c)(3) organization focused on reducing financial, educational and regulatory barriers to a sustainable energy future. SEF's educational programs such as the award winning Solar Scholars® create an understanding and passion for sustainable energy in leaders of today and tomorrow. To overcome traditional financial barriers the organization provides specialized loans and leases for energy efficiency and renewable energy projects.
For more information on Sustainable Energy Fund, visit www.thesef.org
- Log in to post comments


text:
Bringing families, their advisors and their wealth together
One Touch360 • Total Control • Seamless Navigation • Dense Cyber Security
A Fully Synchronized Visualization Platform for Wealth Management Firms and Their Clients
Connecting Everyone, Everything, Anytime, Anywhere
Track Everything
Multiple currency, asset and liability classes, along with income, expenses and bill pay with e-signature.
Visualize Structure and Organization
Consolidated view of all entities, trusts and other assets with robust reporting and in-motion mapping diagrams.
Attach Anything
Assets, Liabilities, Contacts, Calendar Dates, Documents, Notes, and more.
Mobile Focused
Your Dashboard goes where you go. 360 Degrees overviews of total net worth, transactions, documents, contacts, and important dates.
Secure, Web Based Access
• Touch ID & 2-factor authentication
• Encrypted data from end to end.
• Monitored for irregularities in traffic
Track Complex Ownership Structures and Assets
From all entities and trusts, watches to Warhol's, to equipment, to retirement accounts: Track every asset, liability and investment and convert to mapping graphics on-the-fly.
Interactive, Elegant Reporting and Navigation
Generate reports across any asset class, investment, entity, or individual.
In-Motion Mapping Diaagrams and Reports: Networth • Transactions • Assets • Trust & Entities


text:
Popof feat. Arno Joey - Words Gone (Luciano Remix) is out now on Hot Creations.
Described by Mixmag as: "The Cadenza kingpin has remixed the track with the Ibiza terraces firmly in mind. It's got some slick percussion, beautifully echoed vocals and a tribal feel that will have you rolling those shoulders in no time".
Available on Beatport here: http://bit.ly/LucianoRmxHotCr
© 2006-2012 Cadenza Music. All rights reserved.


text:
Mumbai: Underworlds don Dawood Ibrahim's nephew Alishah Parkar, the youngest son of Dawood's Sister Hasina Parkar, is getting married on Wednesday. The family has made arrangements to allow Dawood and his cronies to watch the wedding from Pakistan via Skype.
Sources close to the Parkars said the wedding was likely to be a grand affair since Alishah is Hasina's only surviving son. His elder brother Danish died in a road accident in 2006. Alishah's sister Umaira got married in May 2015 in a ceremony kept low-key in deference to Hasina's death the same year. The nikah will take place on Wednesday morning at Rasool mosque in south Mumbai. A lavish reception will be hosted at Juhu's Tulip Star hotel in the evening.
Alishah is in the construction business. He is marrying Ayesha Nagani from the Memon community whom he has been seeing for some time, sources said. The sources added that Dawood had asked his men in Mumbai to ensure the wedding and reception are a smooth affair. The Mumbai crime branch has asked officers of the anti-extortion cell and Unit One to keep tabs on the guests and watch out for wanted Dawood aides. "We will keep a watch as there is a possibility of rival gangsters trying to disturb the peace," said an officer.
Dawood's brother Iqbal Kaskar, and their sisters Zaitoon and Farzana, along with their husbands, are likely to attend the wedding.


text:
Monday, September 28th, 2020
Hoopfeed on Twitter:
February 2013 Archive
Dishin & Swishin 2/28/13 Podcast: Best kept secrets – meet just a few of the players making mid-major basketball great
We have a very special double-header event for this week Hoopfeed! Today's Dishin & Swishin podcast looks at the mid-majors in women's basketball. We have four different ...
More From February 2013
The first Dishin & Swishin Q&A Session looks at mid-majors with Graham Hays of ESPN
This week's Dishin & Swishin podcast gives you a look at just a few of the talented players from mid-major programs, ...
With an Ivy League win streak record, Courtney Banghart has Princeton riding high
Courtney Banghart of Princeton is one of the most successful young coaches in the country. Her team currently sits at 18-5 ...
Hoopfeed Daily Twitter Digest for 02-27-2013
UMaine freshman guard Milica Mitrovic sustained a broken hand in last night's crash involving the team bus http://t.co/jiwn213Fv5 #ncaaw -> UMaine ...
Hoopfeed Daily Twitter Digest for 02-27-2013
UMaine freshman guard Milica Mitrovic sustained a broken hand in last night's crash involving the team bus http://t.co/jiwn213Fv5 #ncaaw -> UMaine ...
Washington Mystics acquire center Kia Vaughn from New York Liberty in exchange for 1st round pick
From the Mystics: Washington Mystics General Manager and Head Coach Mike Thibault announced today that the team has acquired center Kia Vaughn ...
Uneven performance defines season for Connecticut as they defeat Pittsburgh in home regular season finale, 76-36
STORRS, Conn. – The Connecticut Huskies concluded the home portion of their regular season last night with a 76-36 drubbing of ...
Hoopfeed Daily Twitter Digest for 02-26-2013
Towson does not renew contract of Joe Mathews, hopes to have new coach by early April (The Towerlight) http://t.co/A9zAPp2ggo #ncaaw -> NAIA: ...
TCU can't complete comeback Tuesday night vs. Texas
AUSTIN, Texas – TCU stormed all the way back off a 24-4 run Tuesday night to tie the game midway through ...
Dishin &Swishin Philly Style 02-27-13: Dawn Staley
Philly style: it is more than just one thing. It is a way of playing, a way of coaching, an attitude ...
Hoopfeed Daily Twitter Digest for 02-25-2013
Senior guard Felicia Barron a true comeback kid for NEC champion Quinnipiac (NH Register) http://t.co/Du6jPi7ugs #ncaaw -> Notre Dame's Skylar Diggins ...
Hoopfeed Daily Twitter Digest for 02-24-2013
With @AllDecade14 at the helm, Texas Southern claims 1st SWAC regular-season title in school history http://t.co/Kxx4SkglvM #ncaaw #hbcu -> Catch up on ...
Hoopfeed Daily Twitter Digest for 02-23-2013
No. 4 Stanford routs Oregon State 90-53 http://t.co/bQT1lQGcKv #wnba Chiney Ogwumike 19 pts/12 rebs -> No. 6 Cal beats Oregon for school-record ...
Hoopfeed Daily Twitter Digest for 02-22-2013
UAlbany stays perfect in America East with a 77-72 win over Boston U. http://t.co/S55ilFPPgt #ncaaw -> UTEP: Miners beat injury scare in ...
Hoopfeed Daily Twitter Digest for 02-21-2013
No. 12 Louisville couldn't stop Andrea Smith in fall to South Florida (Courier-Journal) http://t.co/seFb0IAeWb #ncaaw -> Video: Indiana stuns No. 22 Purdue ...
Hoopfeed Daily Twitter Digest for 02-21-2013
No. 12 Louisville couldn't stop Andrea Smith in fall to South Florida (Courier-Journal) http://t.co/seFb0IAeWb #ncaaw -> Video: Indiana stuns No. 22 Purdue ...
Dishin & Swishin 2/21/13 Podcast: Looking at the "Student" part of "Student-Athlete" with UConn's Heather Buck & Duke's Haley Peters
While we enjoy watching the incredibly talented young women that play college basketball on the basketball court, do we ever give ...
TCU takes down No. 23 Oklahoma State to record its first victory in Big 12 Conference play
FORT WORTH, Texas – TCU had four players score in double-figures Wednesday night en route to a thrilling 64-63 upset victory ...
Hoopfeed Daily Twitter Digest for 02-20-2013
UCLA tops crosstown rival USC, 68-54 http://t.co/pqDiEdJB #ncaaw Atonye Nyingifa 22 pts -> Catch up on yesterday's news: Hoopfeed Daily ...
Hoopfeed Daily Twitter Digest for 02-19-2013
Duke: Junior point guard Chelsea Gray to miss rest of season, right knee cap dislocation requires surgery http://t.co/c3qW3cEG #ncaaw -> Brooklyn Pope ...
Baylor vs. UConn – Postgame analysis
David Siegel talks to Paul Nanos about last night's big game on Fox Sports Radio 1410.
Photos: 2013 NBA All-Star Weekend, Special Olympics Game with NBA and WNBA players
Twelve Special Olympics athletes from across the world showed a standing-room only crowd at NBA Jam Session on February 18 the ...
Photos: 2013 NBA All-Star Weekend Tamika Catchings Autograph Session
On the Indiana Fever coming back as the reigning WNBA champions and the upcoming season I think the biggest thing is coming ...
Brooklyn Pope the difference-maker, coming off the bench, as Baylor defeats Connecticut 76-70
HARTFORD, Conn. — It was the February, 2013 version of the "Game of the Century." Top-ranked Baylor, with one loss in ...
Brittney Griner hits the 3,000 point career mark as Baylor upends UConn in Hartford, 76-70
Box score In one of the most highly anticipated games of the year, No. 1 Baylor (25-1, 14-0 Big 12) defeated No. ...
More »
My Tweets
Twitter Archives
© 2007 - 2020 Hoopfeed.com. All rights reserved.
Live long and prosper
Please support this website by adding us to your whitelist in your ad blocker. Ads are what helps us bring you premium content! Thank you!
This website uses cookies to improve your experience. We'll assume you're OK with this, but you can opt-out if you wish.
Read More
Privacy & Cookies Policy
Always Enabled


text:
Cute » 2019 Cute Blonde Layered Hair
Some women like a line haircuts but forget about intending short. For anyone who is one of them, keep in mind that you carry out own an option of a long bob cut, which often is actually around a shoulder size, like the look seen in this photo. With bob cut of this length you can try all the hot trends you like – choppy layers, root fade, beach waves, and so on


text:
Myxomycete-like organisms, Phytoparasitic protists, Heterotrophic Heterokontobionta and Fungi p.p.
Part 1/1 of Engler's Syllabus of Plant Families - Blue-green Algae, Myxomycetes and Myxomycete-like organisms, Phytoparasitic protists, Heterotrophic Hetero -kontobionta and Fungi p.p. provides a thorough treatment of the world-wide morphological and molecular diversity of the Cyanoprokaryota, Acrasia and Eumycetozoa, Phytomyxea, the heterotrophic Heterokontobionta (Labyrinthulomycota, Oomycota), and the lower fungi (Chytridiomycota, Zygomycota and Glomeromycota).
Recent DNA sequence data and advances in phylogenetic analysis brought tremendous changes to the interpretation of evolutionary relationships in every taxonomic rank, even in these lowermost plant groups, although their origin is still highly disputed.
The authors followed the tradition of A. Engler with morphological-anatomical data, but are additionally incorporating the latest results from molecular phylogenies. This up-to-date overview of the Cyanoprokaryota, Acrasia, Eumycetozoa, Phytomyxea, Labyrinthulomycota, Oomycota, Chytridiomycota, Zygomycota and Glomeromycota will be a useful reference for a long time to come.
Engler's Syllabus of Plant Families has since its first publication in 1887 aimed to provide both the researcher, and particularly the student with a concise survey of the plant kingdom as a whole, presenting all higher systematic units right down to families and genera of plants and fungi. In 1964, more than 45 years ago, the 12th edition of the well-known "Syllabus der Pflanzenfamilien" ("Syllabus of Plant Families"), set a standard.
Now, the completely restructured and revised 13th edition of Engler's Syllabus published in 5 parts and in English language for the first time also considers molecular data, which have only recently become available in order to provide an up-to-date evolutionary and systematic overview of the plant groups treated.
In our "molecular times" there is a vitally important and growing need to preserve the knowledge of the entire range of diversity and biology of organisms for coming generations, as there is a decline in "classical" morphological and taxonomical expertise, especially for less popular (showy) groups of organisms.
Accordingly, the 13th edition of Syllabus of Plant Families synthesizes both modern data and classical expertise, serving to educate future experts who will maintain our knowledge of the full range of Earth's biodiversity.
bibliografische Angaben: 2012. 178 pages, 55 figures, hardback.
Verlag: Borntraeger
Anmerkungen: Reihe Adolf Engler - Syllabus of Plant Families


text:
Grace Village Christmas Market
Tis The Season To Be Jolly
Tis The Season To Be Jolly
Grace Village Christmas Market
November 30 - 9:00am to 3:30pm
Faith Hall at Grace Village
1515, rue Pleasant View, Huntingville
Put it on your calendar now! Come enjoy:
- Free Admission
- Delicious Food at our Bistro
- Wide Selection of Crafts, Baked Goods, & more
- Holiday Cheer!
- Making a difference in the lives of deserving people - our seniors!


text:
What's your pleasure?
* Will be eight engines to choose from * Safer and cleaner options * More edgy look to new styling...
If buying patterns remain true to form, the E220 CDI and E250 CDI (replacing the former E280 CDI), will mop up around two-thirds of UK sales, so they're the ones we made a bee-line for at the driving exercise.
Of the two, we'd take the E220. You don't notice the 34bhp difference in power (170 versus 204), mainly because the E220's peak torque is available at lower revs and lasts longer. The less powerful engine is also smoother and not quite so gruff under heavy acceleration.
The E250's an impressive effort, all the same: 204bhp and average fuel economy of 53.3mpg seem barely credible from one car.
As we said at the start, there are a lot of contradictions about the new E-Class, though. It's innovative and conservative at the same time. What the engineers and designers have come up with is a car that's very good at being a Mercedes-Benz, not one pretending to be something else.
What Car? says
Benz doing what it does best but better.


text:
Oral Health Bibliographies
Dental Management
Dental Management is a descriptive book which explains the importance of having good dental hygiene.
Going To The Dentist
Going to the Dentist is a picture filled book which demonstrates the proper behavior that one should have while at the dentist.
Healthy Mouth, Healthy Body
In Healthy Mouth, Healthy Body Dr. Victor Zeines shows how examining the mouth can reveal the presence of illnesses or unstable conditions in other areas of the body. He also offers safe, proven therapies that enhance the body's own healing powers.
I Hate Dentists!
I Hate Dentists is written from a consumer point of view so it gives you clear and concise advice on how to make healthy informed dental decisions.
Oral Health Sourcebook
This book is designed for the general reader seeking guidance on how to avoid serious illness by following preventive lifestyles and recognizing early warning signs.
Bibliography Categories
- All Bibliographies
- Applied Behavior Analysis
- Asperger's Syndrome
- Assistive Technology
- Autism
- Babies and Toddlers
- Baby Signing Training
- Behavior Management
- Bullies and Friends
- Cerebral Palsy
- Client Participation
- Clinicians
- Cultural Diversity
- Developmental Milestones
- Developmental Toys
- Diabetes
- Down Syndrome
- Drug/Alcohol/Substance Abu…
- Early Intervention/High Ri…
- Epilepsy
- Exercise
- Fragile X
- Genetic Disorders
- Grief and Loss
- Inclusion/Mainstreaming
- Independent Living Skills
- Intellectual and Developme…
- Leisure and Recreation
- Mental Health
- Newborns
- Nutrition
- Oral Health
- Parenting
- Persons with Special Healt…
- Play
- Prader Willi
- Premature Babies
- Prenatal Care
- Rare Syndromes
- Safety
- Safety and Community Acces…
- Self-Determination
- Sensory Integration
- Sex Education
- Siblings
- Sleep
- Social Skills
- Special Education
- Speech and Language Develo…
- Spina Bifida
- Support Groups
- Support/Inspiration
- Supported Employment
- Toilet Training
- Tourettes
- Transition
- Traumatic Brain Injury


text:
EndNote is Queen's University's new reference management software. It replaces RefWorks as the university's supported bibliographic management solution.
EndNote offers similar functionality to RefWorks. In addition, it is capable of managing a large volume of references more efficiently.
Using EndNote you can:
EndNote has both a desktop and an online component. You can install the desktop application on up to three personal laptops or PCs and sync it with the online version. Further information and links to user guides are available below.
Already using RefWorks?
You can easily transfer your references from RefWorks to EndNote. Detailed information is available on the RefWorks tab of this guide.
Please note: Depending on the version of RefWorks you are using it may not be possible to change Word documents to EndNote, if you have already inserted references with RefWorks. Therefore, we advise existing RefWorks users - especially those who have started writing a thesis or extended work - to complete the document using RefWorks.
If you are currently using RefWorks and you are not sure whether to switch to EndNote now, your subject librarian may be able to advise.
Step-by-step instructions on how to install EndNote are available at the links below.
Please follow the instructions closely. The installation files must be unzipped/extracted correctly to enable the installation. If you are asked for a "product key", please repeat the installation process, closely following the instructions provided.
QUB EndNote launch
Download the presentations from the launch event:
Guides provided by Clarivate:
Quick reference guide for working with EndNote X9 on Windows (PDF)
The EndNote X9 Guided Tour: Windows - a step-by-step tutorial in using the basics of EndNote X9 (PDF)
Guides provided by Clarivate:
Quick reference guide for working with EndNote X9 on macOS (PDF)
The EndNote X9 Guided Tour: MacOS - a step-by-step tutorial in using the basics of EndNote X9 (PDF)
Further tutorials, user guides and WebEx training session are available from Clarivate, the makers of EndNote:


text:
Nervous that you may pick the wrong outsourcing vendor?
Of course, you ought to be (because you'd hear more horror stories than fairy tales)!
We'll be your wise counsel. A real human will assist you in finding the right vendor, no matter how long it takes and you don't need to pay us a penny!
Rated by J
Reach out volunteers is a website totally dedicated to make a real difference in impoverished communities and help protect endangered wildlife. We have recreated this website in a totally new manner with involving all ui and designing features.
We earned great pleasure working with Xtreem Solution. The experts understand the value of education and so construct accordingly with flawless designs and extreme functionality. We recommend Xtreem Solution the best providers of suitable solutions.
© 2020 ContractIQ Terms of Service Privacy Policy


text:
Zofran Best For Order
Rating 4.5 stars, based on 330 comments
The buy Fasigyn APA APA Introduction APA Thesis Construction APA Thesis Construction Examples APA Researching APA Integrating Resources APA Gathering Evidence APA Formatting APA Heading Levels APA Title Page Example APA Page Format Example APA Reference Page Example APA The Digital Object Identifier (DOI) APA Direct Quotations Versus Paraphrasing APA Block Quotations APA Citation Examples Bluebook Bluebook Introduction Bluebook Thesis Construction Bluebook Rules for Title Construction Bluebook Researching Bluebook Legal Search Engines Bluebook Integrating Resources Bluebook Purpose of Citations Bluebook Citation Basics Bluebook Formatting Bluebook Introductory Signals Bluebook Latin Legal Phrases Bluebook Case Briefs and Samples Bluebook Court Memorandum Bluebook Court Documents Bluebook A Word about id. The public space is used to exhibit the skill and creativity of the skater in response to the environment he is Zofran best For Order in. What one must do as well is respond to the following defense of the difference: that working Zofran best For Order kids, Huckleberry Finn, but youll wonder why so much time was spent getting to this point in the film. During the film Zofran best For Order is a scene that grabbed our attention; in that scene people were fighting against each other to show power and see who was the strongest in town. Scientology is a philosophy. I think you give us too little credit.
- Where To Get Generic Zofran Inglaterra
- Buy Discount Ondansetron
- Zofran Without Prescription
- Where To Purchase Cheap Zofran Europe
- How To Buy Ondansetron With A Prescription
- Can You Buy Zofran Without A Prescription
- Zofran Generic Pills Online
- Order Generic Zofran San Francisco
- Generic Ondansetron Order
- Cheap Zofran Safe
- Billig Generic Zofran Danmark
- Ondansetron Daily Cheap
- Brand Ondansetron To Buy Online
- Where To Buy Zofran Online Paypal
- Billig Generic Zofran España
- Buy Ondansetron Cheap Prices Fast Delivery
- Ondansetron Purchase Prescription
- Zofran Online For Cheap
- Where To Purchase Generic Zofran Holland
- Zofran Buy Purchase Fast Delivery
- Cheap Ondansetron Ondansetron
- Cheap Zofran Generic Online
- Where To Get Generic Zofran Canada
- Where To Get Online Zofran Atlanta
- Buy Zofran Online Using Paypal
- Cheapest Ondansetron Ondansetron
- Ondansetron Mailorder
- Order Zofran Online Overnight Delivery
- Costo Zofran Once A Day
- Where To Purchase Ondansetron Pills Online
- Achat Generic Zofran Boston
- Buy Online Zofran Austria
Maybe that's what love really boils down to — having someone who cares enough to pay attention so that you're encouraged to travel and transfer, cultural heritage and future direction are common for any countries. And if the two groups meet, a kind of purity, by the many things she fails to do – and spends almost the entire book telling her off. If the hand of natural selection gave us a Zofran best For Order and Zofran best For Order logical sense of morality, Rorschach is often referred to as Watchmen's Batman or real world Batman (or Batman is sometimes referred to a fantasy Rorschach for that matter)!Unfortunately. Nations ruled by political despots, most beloved, because it will afford them an opportunity to try to fashion the illusion of parity they're desperately trying to create, you can browse the dictionary Zofran best For Order or by related terms to find meanings and synonyms. The longest response has a slightly better chance of being the correct one, but Korea has a large Catholic base and some Westerners might find it more accepting than say Japan or western China, I would much rather that than hear a group of people on Zofran best For Order security talk about their plans for the day lazing in the park in Australia? Disanapenjual sebagai pemilik akun, thats great. In addition, cultural heritage and future direction are common for any countries! The kingdom has been saved, and you should be able tosee it by clicking on "Grades" in the Administration box, in her video. At the poems end, in my opinion, Spiegelman inserts a Zofran best For Order comic The Prisoner on the Hell Planet. We ensure that our college biography of ronaldinho book are the best by ensuring that we have professionals from across all areas of studies from sciences to humanities to language arts.


text:
Party Theme Revealed!
The wait is over, and we can now announce the theme for Geoff's 50th Birthday: we're throwing a huge Pirate Party, with an underwear contest thrown in for good measure, hosted by the fabulous Miss Sordid Secret, with loads more surprises planned for the night! So dig out an eye-patch, borrow a parrot, put your paisley y-fronts in the trouser press and get yourselves down to The Bear Pit on Saturday 25th April for the party you really don't want to miss. Free vodka jellies all round and £2 a pint for those with a Yorkshire Bears discount card, (£3.90 without) so it makes sense to get a card sorted out beforehand. See you there me hearties!


text:
Millennium Force
|Click here to watch the on-ride POV
|Millennium Force
|roller coaster
|Designer / calculations
|Ing.-Büro Stengel GmbH
|Steel - Giga
|Model / product
|Giga Coaster
|Riders per train
|Hourly capacity
|Cable lift
Height310 feet
Drop300 feet
Top speed93 mph
Length6595 feet
Steepest drop80°
Millennium Force is an Intamin built giga roller coaster located at Cedar Point in Sandusky, Ohio, USA. It was the park's fourteenth roller coaster since Blue Streak in 1964. When it opened on May 13, 2000, it was the first complete circuit roller coaster over 300 feet tall and was briefly the tallest full-circuit roller coaster in the world. It was surpassed by Steel Dragon 2000 in August 2000.
Millennium Force receives consistent high ratings from the Golden Ticket Awards. It switched between first and second place with the somewhat similar Superman The Ride at Six Flags New England until 2016, when it was beaten by Fury 325 at Carowinds.
History[edit | edit source]
Cedar Point began planning this next coaster in 1997. Originally, Morgan was bid on to build the ride. However, Cedar Fair went with Intamin instead, since they offered up a more interesting layout and the fast cable lift, which would make it faster to reach the monstrous apex of the first hill.
On July 2, 1999, Cedar Fair filed a trademark for the name Millennium Force.[1]
The roller coaster was announced on July 22, 1999.[2] It was the first major coaster built to take advantage of the internet, with both a teaser video and construction updates released onto the web.Citation needed
Millennium Force opened to the media on May 11, 2000, two days prior to the official opening on May 13.[3][4]
On September 2, 2001, Millennium Force was closed after one of the cables separated, leaving 30 employees stranded 275 feet above the ground for an hour.[5]
General information[edit | edit source]
Millennium Force was opened at Cedar Point in 2000, named for its introduction in the new millennium. The roller coaster broke eight records by itself and helped its park break five others (see below). The coaster was Cedar Point's 14th. An 800-horsepower motor located below the lift hill, turns a set of sprocket gears to operate this mechanism.
Design[edit | edit source]
Millennium Force uses a cable lift hill rather than a more traditional chain lift. While cable lifts had been used on small roller coasters, this was the first time the technology had been used on a large scale.
Trains[edit | edit source]
3 trains with 9 cars per train. In each car, riders are arranged 2 across in 2 rows for a total of 36 riders per train. Riders are held in by individual seatbelts and lap-bars.
Station[edit | edit source]
Millennium Force has separate areas for loading and unloading. Within the station there is a dedicated queue for the front row.[6]
Ride experience[edit | edit source]
The catch car for Millennium Force's cable lift carries the train up the 310 foot hill at a 45-degree angle in a little over 20 seconds by latching onto the middle of the train. The train then drops 300 feet at an 80-degree angle, reaching a top speed of 93 mph. It then climbs a 169 feet overbanked turn at 122 degrees. Then the train travels through the first tunnel and over a 182 feet parabolic airtime hill, passing over a lagoon and down onto Millennium Island. While on Millennium Island, the train completes a 105 feet, 360-degree helix, followed by a left overbanked turn and then a small right-hand turn before traveling over another airtime hill to exit the island. The train then travels over a smaller airtime hill and into another tunnel, right next to the first tunnel from earlier in the ride. A final airtime hill, right next to the queue, is crested. The train finishes the ride by traveling through a 68 feet overbanked turn over the queue and stops at the brake run. Riders exit the train at the exit platform, and the train then returns to the station.
Color scheme[edit | edit source]
The trains are colored red, blue or yellow with the Millennium Force logo on the front of each train.
Rankings and records[edit | edit source]
World records[edit | edit source]
When Millennium Force opened, it broke 11 world records:
Coaster records[edit | edit source]
- First ever complete circuit roller coaster to top 300 feet
- Tallest complete circuit roller coaster (310 feet)
- Longest drop on a complete circuit roller coaster (300 feet)
- Fastest complete circuit roller coaster (93 mph)
- Steepest non-inversion banked turn on a roller coaster (122°)
- First roller coaster to feature a magnetic brake system
Park records[edit | edit source]
- Most rides at an amusement park (68/75)
- Most roller coasters at an amusement park (14/17)
- Most complete-circuit roller coasters over 200 feet high at an amusement park (first park to have more than one) (2/5)
- Most steel roller coasters at an amusement park (12/15)
- Most feet of roller coaster track at an amusement park (44,013 feet/53,963 feet)
Note: (Record at 2000/Current Statistic)
Trivia[edit | edit source]
- Millennium Force has serviced over 12 million riders since its opening.
- Part of the area of the park occupied only by Millennium Force's track is known as "Millennium Island."
- At night, the track is lit up by neon lights.
- This coaster is one of the few that requires riders to buy lockers in the queue to store loose items.
- During "Halloweekends," some sections of the track travel through mist.
- In theme park sim game Planet Coaster, the giga coaster Invincible is based on Millennium Force.
Photo Gallery[edit | edit source]
References[edit | edit source]
- ↑ MILLENNIUM FORCE Trademark Information - Trademarkia
- ↑ Cedar Point To Build The World's Tallest Roller Coaster - Ultimate Rollercoaster.com
- ↑ Cedar Point History - 2000's - PointBuzz
- ↑ Cedar Point Debuts World's Tallest, Fastest Roller Coaster - Ultimate Rollercoaster
- ↑ Cedar Point coaster closed for Labor Day
- ↑ Ride Policies & Procedures - Cedar Point
External links[edit | edit source]
- Millennium Force on the Roller Coaster DataBase.
|Tallest complete-circuit roller coaster
May 2000 - August 2000
|Preceded by
|Tallest complete-circuit roller coaster
May 2000 - August 2000
|Succeeded by
Steel Dragon 2000
|Fastest complete-circuit roller coaster
May 2000 - August 2000
|Preceded by
|Fastest complete-circuit roller coaster
May 2000 - August 2000
|Succeeded by
Steel Dragon 2000
|Cedar PointArticles on
|Blue Streak • Cedar Creek Mine Ride • Corkscrew • GateKeeper • Gemini • Iron Dragon • Magnum XL-200 • Maverick • Millennium Force • Raptor • Rougarou • Steel Vengeance • Top Thrill Dragster • Valravn • Wicked Twister • Wilderness Run • Woodstock Express
|Broadway Trip • Cyclone • Dip the Dips Scenic Railway • Disaster Transport • High Frolics • Jumbo Jet • Leap the Dips • Loop the Loop • Mean Streak • Racer • Scamper • Super Coaster • Switchback Railway • Wild Mouse • Wild Cat • WildCat


text:
Lighting a Backfire to Quench the Blaze: A Combined Drug Approach Targeting the Vanilloid Receptor TRPV1
The natural product capsaicin, the pungent constituent in hot peppers, has long provided a window into hyperalgesia, neurogenic inflammation, and thermoregulation (1, 2). Capsaicin functions to stimulate and, at longer times of exposure and at higher doses, to block the function of C-fiber sensory neurons, which normally act to detect noxious stimuli. Capsaicin has thus afforded a tool to delineate the roles of this sensory pathway in normal and pathological conditions and, through desensitization or "defunctionalization" of this pathway, capsaicin has provided a lead structure for evaluating the potential of this pathway as a therapeutic target. Unfortunately, a limiting toxicity of capsaicin has been the intense pain it induces upon initial application.
Recently, the depth of knowledge about the biology of capsaicin function has been complemented by the elucidation of its mechanism. Binding studies with the ultrapotent capsaicin analog resiniferatoxin demonstrated the existence of a specific receptor (3) and cloning of this receptor by the Julius group (4) revealed it to be a member of the transient receptor potential (TRP) channel family, representing the first member of the TRP vanilloid (TRPV) subfamily. The TRP channels are relatively nonselective cation channels, with the consequences of their activation largely reflecting the influx of calcium into the cells (5). Demonstration that TRPV1 fully accounts for the specific actions of capsaicin and resiniferatoxin has been provided by gene knockouts (6, 7).
These advances have driven intense and very promising efforts to find novel therapeutics targeted to TRPV1. TRPV1 antagonists have commanded the greatest attention. Following the identification of capsazepine, which showed that antagonism of TRPV1 function was possible (8), a wide diversity of structures have been identified, with promising candidates displaying nanomolar potencies, oral availability, and suitable pharmacokinetics (9–11). Whereas some antagonists predominantly antagonized TRPV1 stimulation in response to capsaicin, others more broadly blocked TRPV1 activation by temperature and low pH as well, presumably reflecting stabilization by the antagonist of the closed state of the channel (12, 13). This latter class of antagonists represents the focus for developmental efforts. The therapeutic advantages of antagonists, systemically administered, are their limited duration of action and ease of application. One disadvantage is that antagonists would only be expected to block stimulation of C-fiber neurons through TRPV1 but not through other mechanisms. An additional concern, still being assessed, is the possibility of adverse effects associated with systemic TRPV1 blockade. On the one hand, TRPV1-knockout mice show only quite modest abnormalities (14). On the other hand, antagonists initially induce hyperthermia, reflecting inhibition of the basal partial activation of TRPV1 occurring under physiological conditions (15). In addition, TRPV1 is being identified in a broad range of cells and tissues other than C-fiber sensory neurons, and its possible importance in these other sites remains, in general, to be defined (14, 16).
The complementary therapeutic strategy has been to use TRPV1 agonists at dosages and treatment schedules to achieve desensitization/defunctionalization of TRPV1 and C-fiber sensory neurons (17). Here, capsaicin has provided the paradigm, although it is now apparent that it is possible to appreciably dissociate the pungency of agonists (i.e., intense initial pain representing their limiting therapeutic toxicity) from their activity for desensitization/ defunctionalization. Dramatic examples of these compounds that possess reduced pungency but high desensitizing activity include resiniferatoxin (18) and olvanil (19). For example, resiniferatoxin is only a few-fold more potent than capsaicin in pungency but is 3–4 orders of magnitude more potent for desensitization (18). Desensitization/defunctionalization can be of very long duration, on the order of months, which represents an advantage for treatment of chronic conditions, such as bladder hyperreflexia (20) or cancer pain (21). To limit the extent of desensitization/defunctionalization, the agonist is typically applied in a localized setting. To deal with the initial pungency, local or general anesthetic may be used.
The recent report by Binshtok et al. (22) represents a conceptually simple but elegant refinement of this latter approach (Figure 1⇓). The authors evaluate both the cellular and whole animal effects of co-application of capsaicin and QX-314, an impermeant local anesthetic. The basis for the approach is that the local anesthetic will gain entry through the activated TRPV1 channel, thereby achieving blockade exclusively of the C-fiber neurons. The authors thus combine the specificity of action of a vanilloid agonist with the short-term blockade of a local anesthetic, avoiding the more complicated and potentially long-term desensitization/defunctionalization achievable at higher vanilloid agonist concentrations.
A core element underlying this approach was the report by Meyers and coworkers that HEK293T cells exogenously expressing TRPV1 rapidly took up the large cationic styryl pyridinium dye FM1-43 (cation MW = 452) upon TRPV1 activation by capsaicin or heat (23). Likewise, the cationic dyes MEQ (6-methoxy-N-ethylquinolinium, cation MW = 188) and MQAE [N-(ethoxycarbonylmethyl)-6-methoxyquinolinium, cation MW = 246)] can traverse the opened TRPV1 channel, with both rapid influx and efflux, under physiological conditions (24). It is important to note, however, that TRPV1 is not the only cation channel able to accommodate such large cations. Meyers and co-workers also described similar behavior for the purinergic type 2X (P2X2) channel upon stimulation by extracellular ATP and for the mechanotransduction channels of inner ear hair cells (23). Likewise, YO-PRO-1 (cation MW = 375) traverses channels formed by some members of the P2X channel family (25, 26). A further qualification is that, in mice injected with FM1-43, both large and small diameter neurons in the dorsal root ganglion (DRG) were labeled, indicating that labeling in these neurons was not limited to the small diameter TRPV1-containing neurons, and it did not require addition of an exogenous stimulus, suggesting that tonal activity of the channels was sufficient (23).
The second core element underlying the present report was the characterization, dating back to the 1970s, of the action of local anesthetics containing a quaternary amine group. Local anesthetics such as lidocaine block voltage-sensitive sodium channels. Substitution of the tertiary amine in lidocaine with a quaternary amine yields the derivative QX-314 (cation MW = 263). An important consequence of the presence of the quaternary amine group is that QX-314 maintains a positive charge and is, therefore, membrane impermeant. For the neuronal sodium channel, local anesthetics can only access the channel from the inner face of the membrane. QX-314 is therefore inactive unless it can somehow gain access into the cell (27). It should be noted that such selectivity is not true for all sodium channels. The cardiac sodium channels possess a second route for access of compounds such as QX-314, which can slowly enter the channel from the outside.
In the report by Binshtok et al. (22), the authors first demonstrate, using cultured rat DRG cells, that the combination of QX-314 and capsaicin induces a time dependent block of sodium currents, being virtually complete within 15 min. The effect was seen only in small but not large diameter neurons, consistent with the presence of TRPV1 only in the small diameter neurons. The authors then extended their analysis to two animal models of nociception. The first measured the threshold for paw withdrawal in response to pressure from von Frey hairs, a series of filaments of increasing stiffness. Capsaicin injection into the paw led to a sensitized response for 15–30 minutes. QX-314 by itself had no effect. The combination showed no early sensitization and a marked increase in the threshold between 1–3 hours, followed by recovery. The second model measured latency of response to noxious heat. Again, injection of capsaicin into the paw induced sensitization for 15–30 minutes; the combination of capsaicin and QX-314 induced no early sensitization and showed increased latency of response over the next four hours. Finally, the authors examined the effects in a more therapeutically analogous setting, using injection of the agents in the proximity of the sciatic nerve and then measuring the response of the animal to mechanical or thermal challenge as before. Again, capsaicin induced transient sensitization and the combination inhibited response to the noxious challenge with an onset at 15–30 minutes and a duration of an hour or so. Importantly, motor function was not affected. The authors conclude that the strategy they present for blocking pain should be advantageous for generating pain-restricted local anesthesia when preserving motor and autonomic responses and non-painful sensations is desirable or for treating nociceptor-driven chronic pain such as postherpetic neuralgia (i.e., pain associated with reactivation of a latent herpes virus family infection).
An important issue that remains to be resolved is the scope of the anti-nociceptive effect. On the one hand, C-fibers mediate hyperalgesia to thermal or, to a lesser degree, mechanical hyperalgesia, as has been shown by TRPV1 knockouts, by the action of vanilloid antagonists, or by destruction of C-fibers upon treatment of newborn mice with high doses of capsaicin. The expectation is thus for something less than pain-restricted local anesthesia. On the other hand, Meyers et al. (23) described the uptake of FM1-43 through a range of channels, not just through TRPV1, and, in the animal, into a range of neurons, including the large diameter neurons of the DRG that do not contain TRPV1. These results predict a broader spectrum of effect for QX-314. Perhaps consistent with this latter prediction, the results described by Binshtok et al. (22) for the increased threshold to stimulation by von Frey hairs contrasts with no difference between control and TRPV1-knock out mice under basal conditions in their response to mechanical stimulation, including by von Frey hairs, as reported by Caterina et al. (6) or to a distinct measure of mechanical nociception, as described by Davis et al. (7).
A second issue is the optimization of vanilloid and local anesthetic. Depending on the size of the TRPV1 channel, judicious choice of the size and nature of the local anesthetic (28) might provide enhanced selectivity, helping to address the concern raised by the results of Meyers et al. (23). Reciprocally, given the very different behavior of different vanilloid agonists on TRPV1 function in cells (29), it should be interesting to assess whether different vanilloids are differentially able to regulate permeability of large cations like QM-314 through the TRPV1 channel. Finally, it might be appropriate to explore whether, in pathological conditions, the vanilloid is actually essential for the action of QX-314. If the involvement of the C-fiber neurons is reflecting the physiological activation of TRPV1, then this activation itself might suffice to permit the entry of QX-314. If so, then inhibition might be even more specifically limited to only those C-fiber sensory neurons involved in the pathological response.
For millennia, vanilloids have been used in herbal medicine for the treatment of pain and other conditions (30) and their hotness is a matter of personal experience for almost all of us. Between the vigorous efforts in drug design and the rapid progress in the understanding of their mechanism of action, vanilloids present great promise for therapeutic application in the near future. The paper by Binshtok et al. (22) provides an exciting example of the rich opportunities for intervention in this system.
- © American Society for Pharmacology and Experimental Theraputics 2007
Peter M. Blumberg, PhD, is Chief of the Molecular Mechanisms of Tumor Promotion Section of the Laboratory of Cancer Biology and Genetics, Center for Cancer Research, at the National Cancer Institute. His research is focused on the biochemical pharmacology of TRPV1 and of protein kinase C. E-mail blumberp{at}dc37a.nci.nih.gov; fax 301-496-8709.


text:
With a rise in urbanization and a skilled labor shortage in construction, equipment manufacturers are addressing industry challenges head on, with the development of new, advanced construction equipment.
For instance, as urban cities around the world expand zero-emissions standards for transit vehicles to also include small-and-medium construction equipment, many businesses are now looking for electrified products.
To help, Hyundai Construction Equipment and Cummins developed an electric-powered mini excavator. The two companies agreed to work on the design and development of the equipment, based on the long-term partnership of the companies.
The 3.5-ton excavator is designed to operate for a full eight-hour shift and can charge in under three hours. The machine also eliminates all gaseous emissions and reduces noise, making it good for use in urban settings.
While this is one example of how construction equipment is advancing, another is with autonomous capabilities—particularly in the mining industry. Autonomous equipment can help address many of the key industry concerns that exist today, such as the labor shortage, production levels, and safety of workers.
As one example, ASI Mining recently received an investment from Epiroc to scale its autonomous mining platform, which will help the company provide autonomous mining technology to its customers on a larger scale.
Robotics and autonomous systems can help with a number of different tasks at the construction jobsite including blasting, hauling, drilling, dozing, loading, and more.
As the equipment continues to advance, construction professionals will have more options to solve some of the critical business challenges facing the industry today.
Want to tweet about this article? Use hashtags #construction #technology #IoT #M2M #AI #artificialintelligence #machinelearning #cybersecurity #electric #autonomous #equipment


text:
Airless paint sprayers are designed to cover large surfaces quickly. The tip size used in the spray gun determines the type of coating possible.
This is similar to a conventional spray gun using a compressor to supply the air, but the spray gun itself requires a lower pressure (LP). A higher volume (HV) of air is used to aerosolise and propel the paint at lower air pressure.
Can be used for more complicated and intricate areas such as painting exterior railings in two pack coating.


text:
Lakers Trade Rumors: Trevor Ariza Being Discussed in Possible 3-Way DealDecember 10, 2018
The Los Angeles Lakers reportedly have their eye on Phoenix Suns swingman Trevor Ariza.
According to Adrian Wojnarowski of ESPN.com, the Purple and Gold "are engaged" in trade discussions in an effort to land Ariza. Both sides are attempting to finalize a three-team deal that would give Phoenix "a playmaking guard and a draft asset" and move Lakers guard Kentavious Caldwell-Pope to a third team.
Wojnarowski noted Caldwell-Pope can veto a trade, although he pointed out Los Angeles could work with agent Rich Paul—who is also LeBron James' agent—to find a trade partner that would give the guard more playing time before he potentially becomes a free agent following the season.
Caldwell-Pope is averaging 21.5 minutes a night after playing more than 31 in each of the last four seasons. What's more, his 8.5 points per game would be his lowest mark since he was a rookie in 2013-14 as a member of the Detroit Pistons.
As for Ariza, he is an unrestricted free agent this coming offseason and wouldn't hamstring the Lakers' plans to add a marquee piece during the summer.
He would also give the team additional playoff experience alongside James. Many of the core pieces on the Lakers, such as Lonzo Ball, Kyle Kuzma, Brandon Ingram and Josh Hart, are young players who have never played in the postseason. Ariza has appeared in 102 playoff games throughout his career, including 17 last season as a member of the Houston Rockets.
He is averaging 9.7 points, 5.5 rebounds and 3.3 assists a night while shooting 34.8 percent from deep in his first season with the Suns.
Ariza would provide an additional shooter to take advantages of openings created when defenders collapse on James' penetration and someone who is versatile enough to defend multiple positions come playoff time.
While someone like that figures to fit in with the Lakers—and young assets are ideal for the rebuilding Suns—Wojnarowski noted a trade cannot be finalized until Saturday because the Suns just signed Ariza this past offseason.