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Success Advice
21 Reasons Why Successful People Meditate
A little over a year ago I was fortunate enough to learn Transcendental Meditation while I was staying in LA. I was very close minded about Meditation and felt that I was able to manage my day to day life just find without it. My fiance' Charlene insisted that I give it a try, even if I just try it one time. So I did, and I am so happy I followed it through.
I have been meditating twice a day, ever since, and the benefits are amazing and very evident when it comes to a positive change in mood/focus and energy.
I discovered this great article on Huffington Post about the benefits of meditation and thought that it would be a great read for all of those who are looking at getting a handle on their mental and physical balance.
1. It lowers stress – literally
Research published just last month in the journal Health Psychology shows that mindfulness is not only associated with feeling less stressed, it's also linked with decreased levels of the stress hormone cortisol.
2. It makes your brain plastic
Quite literally, sustained meditation leads to something called neuroplasticity, which is defined as the brain's ability to change, structurally and functionally, on the basis of environmental input.
For much of the last century, scientists believed that the brain essentially stopped changing after adulthood.
But research by University of Wisconsin neuroscientist Richard Davidson has shown that experienced meditators exhibit high levels of gamma wave activity and display an ability — continuing after the meditation session has attended — to not get stuck on a particular stimulus. That is, they're automatically able to control their thoughts and reactiveness.
3. It lets us get to know our true selves
Mindfulness can help us see beyond those rose-colored glasses when we need to really objectively analyze ourselves.
A study in the journal Psychological Science shows that mindfulness can help us conquer common "blind spots," which can amplify or diminish our own flaws beyond reality.
4. It can make your grades better
Researchers from the University of California, Santa Barbara, found that college students who were trained in mindfulness performed better on the verbal reasoning section of the GRE, and also experienced improvements in their working memory.
"Our results suggest that cultivating mindfulness is an effective and efficient technique for improving cognitive function, with widereaching consequences," the researchers wrote in the Psychological Science study.
5. It improves performance and ability
The U.S. Marine Corps is in the process of seeing how mindfulness meditation training can improve troops' performance and ability to handle — and recover from — stress.
6. It could help people with arthritis better handle stress
A 2011 study in the journal Annals of Rheumatic Disease shows that even though mindfulness training may not help to lessen pain for people with rheumatoid arthritis, it could help to lower their stress and fatigue.
7. It changes the brain in a protective way
University of Oregon researchers found that integrative body-mind training — which is a meditation technique — can actually result in brain changes that may be protective against mental illness. The meditation practice was linked with increased signaling connections in the brain, something called axonal density, as well as increased protective tissue (myelin) around the axons in the anterior cingulate brain region.
8. It works as the brain's "volume knob"
Ever wondered why mindfulness meditation can make you feel more focused and zen? It's because it helps the brain to have better control over processing pain and emotions, specifically through the control of cortical alpha rhythms (which play a role in what senses our minds are attentive to), according to a study in the journal Frontiers in Human Neuroscience.
9. It makes music sound better
Mindfulness meditation improves our focused engagement in music, helping us to truly enjoy and experience what we're listening to, according to a study in the journal Psychology of Music.
10. It has four elements that help us in different ways
The health benefits of mindfulness can be boiled down to four elements, according to a Perspectives on Psychological Science study: body awareness, self-awareness, regulation of emotion and regulation of attention.
11. It helps us even when we're not actively practicing it
You don't have to actually be meditating for it to still benefit your brain's emotional processing. That's the finding of a study in the journal Frontiers in Human Neuroscience, which shows that the amygdala brain region's response to emotional stimuli is changed by meditation, and this effect occurs even when a person isn't actively meditating.
The Positive Benefits of Meditation
12. It could make going through cancer just a little less stressful
Research from the Jefferson-Myrna Brind Center of Integrative Medicine shows that mindfulness coupled with art therapy can successfully decrease stress symptoms among women with breast cancer. And not only that, but imaging tests show that it is actually linked with brain changes related to stress, emotions and reward.
13. It could help doctors be better at his/her job
Doctors, listen up: Mindfulness meditation could help you better care for your patients. Research from the University of Rochester Medical Center shows that doctors who are trained in mindfulness meditation are less judgmental, more self-aware and better listeners when it comes to interacting with patients.
14. It makes you a better person
Sure, we love all the things meditation does for us. But it could also benefit people we interact with, by making us more compassionate, according to a study in the journal Psychological Science.
Researchers from Northeastern and Harvard universities found that meditation is linked with more virtuous, "do-good" behavior.
15. It could help the elderly feel less lonely
Loneliness among seniors can be dangerous, in that it's known to raise risks for a number of health conditions. But researchers from the University of California, Los Angeles, found that mindfulness meditation helped to decrease these feelings of loneliness among the elderly, and boost their health by reducing the expression of genes linked with inflammation.
16. It lowers depression risk among pregnant women
As many as one in five pregnant women will experience depression, but those who are at especially high risk for depression may benefit from some mindfulness yoga.
"Research on the impact of mindfulness yoga on pregnant women is limited but encouraging," study researcher Dr. Maria Muzik, M.D., an assistant professor of psychiatry at the University of Michigan, said in a statement. "This study builds the foundation for further research on how yoga may lead to an empowered and positive feeling toward pregnancy."
17. It could make your health care bill a little lower
Not only will your health benefit from mindfulness meditation training, but your wallet might, too.
Research in the American Journal of Health Promotion shows that practicing Transcendental Meditation is linked with lower yearly doctor costs, compared with people who don't practice the meditation technique.
18. It comes in handy during cold season
Aside from practicing good hygiene, mindfulness meditation and exercise could lessen the nasty effects of colds.
Researchers from the University of Wisconsin School of Medicine and Health found that people who engage in the practices miss fewer days of work from acute respiratory infections, and also experience a shortened duration and severity of symptoms.
19. It also lowers depression risk among teens
Teaching teens how to practice mindfulness through school programs could help them experience less stress, anxiety and depression, according to a study from the University of Leuven.
20. It helps you sleep better
We saved the best for last! A University of Utah study found that mindfulness training can not only help us better control our emotions and moods, but it can also help us sleep better at night.
"People who reported higher levels of mindfulness described better control over their emotions and behaviors during the day. In addition, higher mindfulness was associated with lower activation at bedtime, which could have benefits for sleep quality and future ability to manage stress," study researcher Holly Rau said in a statement.
21. It supports your weight-loss goals
Trying to shed a few pounds to get to a healthier weight? Mindfulness could be your best friend, according to a survey of psychologists conducted by Consumer Reports and the American Psychological Association.
Mindfulness training was considered an "excellent" or "good" strategy for weight loss by seven out of 10 psychologists in the survey.
Article originally appeared on: Huffington Post
16 Comments
Even doing soliloquy is one way to meditate as long as you feel relaxed and stress-free.
Good summary – I have really enjoyed the comments too which have some great concise tips on starting out. Thanks Joel
Great information, have only tried once since reading this (earlier today) and feel a little bit more in control. Running your own business can be over whelming at times and the opportunities which you created yesterday can be missed today because your head is all over the place. So far, much better than coffee.
Great article,
Thank you
I meditate and have been for the last few months straight. I love it and actually love doing it in the morning. I started using something called 'headspace' and it is awesome for simple guided meditations.
Thanks A2S!
HI Joel,
There is nothing better than a good uninterrupted meditation session!
All you need is 10 minute a day
Great list. Most people really do underestimate the power of mediating. Start today if you don't
Amen Joel! Everyday meditating for years here. At least 10 minutes, most days more. Thanks!
To start meditation is very easy. You don't have to go to some place or club or group to start. You don't have to wear coloured robes or get funny haircuts or wear beads. You don't have to look at deities , breath in a special way or say stuff over and over in your mind. You don't have to pay anyone to learn to meditate.
If you are a type of person that can't go on a diet without doing it with someone else or need the social interaction of belonging to a gym to get motivation to train etc , then yes , go and find some Guru or place where you can meditate together.
But the reality is all you have to do is sit down on the floor cross legged and close your eyes. Keep your back straight but without forcing it too much. Try resting your hands on your knees. If you have back trouble etc, just sit in a chair. Don't try to breath more deeply , just let it happen. Just let your thoughts come and go. With time you will find that you don't have to forcefully try remove unwanted thoughts or day dreaming. Ideally aim for about 1 hour. I have meditative type trance music like Steve Roach in the background. I know the CD is about an hour long long so when the music stops, you session is finished. When you start you won't be able to (well most people anyway) sit for that long without the discomfort getting to you, sore buttocks, numbness in feet and so forth.
That is why they invented yoga and kung fu to toughen and stretch the body so the physical body could stay in the lotus meditation position longer. For those really wanting to get the most of meditation, sit in the lotus position. Anatomically, it switches blood supply from femoral artery and sends more blood to the brain…
How do you know when you are really in a deep meditative state. Get one finger now and block one nostril and breath and then do the other side. You will find that one side is more blocked than the other. In 2 hours time or so, it will switch around. This is normal. When you have reached a certain point in meditation, you will feel both nostrils suddenly open up as if you have suddenly cleared your sinuses, At the same time you feel centred , clear, relaxed etc all at the same time, and your breathing will automatically just be relaxingly deep .
If you need an excuse and motivation to start meditation, remember all the great success books, Think and Grow Rich, Dale Carnegie, and numerous other "successful" people all talk about focusing and visualising your goals, and developing concentrating, being decisive etc. You can tell yourself to " concentrate better" or be "decisive" all that you want, but if your constitution and brain power is lacking, you will never get it. But luckily meditation will build that mental strength. Some people will say, I can't meditate because my mind is too busy etc. That makes as much sense as saying, I won't take up running because I am not fit or I won't start saving money because I am broke.
If you have enough strength to just make one decision, decide to give up 1 hour of TV or checking emails and meditate each night instead.
u r an angel to describe it so beautifully and kindly 🙂
I second Jazzel's comment. What is the the best way to get started?
I meditate every night before I go to bed. I find it's not about just letting go of the stress from your day and life, but to reconnect with yourself and have some nice one-on-one time.
I think it's more than obvious that meditation, yoga, workout, and eating healthy foods can help you chase your vision x1000 times more than avoiding them. Everybody knows that, we all know the benefits, and yet we don't do it. It's like people don't want happiness.
Read this post, remember it, bookmark it, and wherever you feel anxious, sad, tired, just re-read it again and start meditating. It's very easy sometimes.
how do I do it? How can I start?
Hi Jazzel, Here's one way to meditate. Sit quietly and comfortably. Focus on your breath going in and out. As thoughts come – as they inevitably will – simply notice that you've had a thought, then get back to concentrating on your breath. Do for 10 minutes per day. Simple but not easy!
Hello, where i can found a good start course to learn meditation?
Hey Joel,
Thanks for sharing, and also glad to hear you're meditating daily! I'm a big believer in the power of meditation, especially for us entrepreneurs who can easily burn out if we don't get that much needed down time to defrag our minds! I've found it's made a huge difference for me too and certainly helps maintain a longer term focus… It's totally worth the time investment!
Thanks again 🙂
Steve Jobs loved it.
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In this module, we will derive an expansion for continuous-time, periodic functions, and in doing so, derive the Continuous Time Fourier Series (CTFS).
Since complex exponentials are eigenfunctions of linear time-invariant (LTI) systems , calculating the output of an LTI system given as an input amounts to simple multiplication, where is the eigenvalue corresponding to s. As shown in the figure, a simple exponential input would yield the output
Using this and the fact that is linear, calculating for combinations of complex exponentials is also straightforward.
The action of on an input such as those in the two equations above is easy to explain. independently scales each exponential component by a different complex number . As such, if we can write a function as a combination of complex exponentials it allows us to easily calculate the output of a system.
Joseph Fourier demonstrated that an arbitrary can be written as a linear combination of harmonic complex sinusoids
The - called the Fourier coefficients - tell us "how much" of the sinusoid is in . The formula shows as a sum of complex exponentials, each of which is easily processed by an LTI system (since it is an eigenfunction of every LTI system). Mathematically, it tells us that the set ofcomplex exponentials form a basis for the space of T-periodic continuous time functions.
We know from Euler's formula that
Finding the coefficients of the Fourier series expansion involves some algebraic manipulation of the synthesis formula. First of all we will multiply both sides of the equation by , where .
Consider the square wave function given by
on the unit interval .
Thus, the Fourier coefficients of this function found using the Fourier series analysis formula are
Because complex exponentials are eigenfunctions of LTI systems, it is often useful to represent signals using a set of complex exponentials as a basis. The continuous time Fourier series synthesis formula expresses a continuous time, periodic function as the sum of continuous time, discrete frequency complex exponentials.
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text: Rich & Tabby. All my wedding are so special to me. I love each and every one. They are all full of hope and love and this wedding was from the start full of both. It was elegant and Tabby's heart was only set on the one she loved. I enjoyed seeing her enjoy the day and not worry or fuss about one little thing. She was making memories and was enjoying each and every moment. Every detail of this wedding was so carefully planned. The decorations and the menu and the flowers and the dresses…oh…did I mention the flowers! Each bouquet made with love by Tabby's mom. Each decoration. Each detail. Made with love. She really should be an event planner. One of the best I've seen! Thank you Rich and Tabby. Your love for each other stays in my heart. I so enjoyed being a part of your day. It meant the world to me to be there as two became one.


text:
Admixture Mapping Scans Identify a Locus Affecting Retinal Vascular Caliber in Hypertensive African Americans: the Atherosclerosis Risk in Communities (ARIC) Study
Retinal vascular caliber provides information about the structure and health of the microvascular system and is associated with cardiovascular and cerebrovascular diseases. Compared to European Americans, African Americans tend to have wider retinal arteriolar and venular caliber, even after controlling for cardiovascular risk factors. This has suggested the hypothesis that differences in genetic background may contribute to racial/ethnic differences in retinal vascular caliber. Using 1,365 ancestry-informative SNPs, we estimated the percentage of African ancestry (PAA) and conducted genome-wide admixture mapping scans in 1,737 African Americans from the Atherosclerosis Risk in Communities (ARIC) study. Central retinal artery equivalent (CRAE) and central retinal vein equivalent (CRVE) representing summary measures of retinal arteriolar and venular caliber, respectively, were measured from retinal photographs. PAA was significantly correlated with CRVE (ρ = 0.071, P = 0.003), but not CRAE (ρ = 0.032, P = 0.182). Using admixture mapping, we did not detect significant admixture association with either CRAE (genome-wide score = −0.73) or CRVE (genome-wide score = −0.69). An a priori subgroup analysis among hypertensive individuals detected a genome-wide significant association of CRVE with greater African ancestry at chromosome 6p21.1 (genome-wide score = 2.31, locus-specific LOD = 5.47). Each additional copy of an African ancestral allele at the 6p21.1 peak was associated with an average increase in CRVE of 6.14 µm in the hypertensives, but had no significant effects in the non-hypertensives (P for heterogeneity <0.001). Further mapping in the 6p21.1 region may uncover novel genetic variants affecting retinal vascular caliber and further insights into the interaction between genetic effects of the microvascular system and hypertension.
Published in the journal:
. PLoS Genet 6(4): e32767. doi:10.1371/journal.pgen.1000908
Category: Research Article
doi: 10.1371/journal.pgen.1000908
Retinal vascular caliber provides information about the structure and health of the microvascular system and is associated with cardiovascular and cerebrovascular diseases. Compared to European Americans, African Americans tend to have wider retinal arteriolar and venular caliber, even after controlling for cardiovascular risk factors. This has suggested the hypothesis that differences in genetic background may contribute to racial/ethnic differences in retinal vascular caliber. Using 1,365 ancestry-informative SNPs, we estimated the percentage of African ancestry (PAA) and conducted genome-wide admixture mapping scans in 1,737 African Americans from the Atherosclerosis Risk in Communities (ARIC) study. Central retinal artery equivalent (CRAE) and central retinal vein equivalent (CRVE) representing summary measures of retinal arteriolar and venular caliber, respectively, were measured from retinal photographs. PAA was significantly correlated with CRVE (ρ = 0.071, P = 0.003), but not CRAE (ρ = 0.032, P = 0.182). Using admixture mapping, we did not detect significant admixture association with either CRAE (genome-wide score = −0.73) or CRVE (genome-wide score = −0.69). An a priori subgroup analysis among hypertensive individuals detected a genome-wide significant association of CRVE with greater African ancestry at chromosome 6p21.1 (genome-wide score = 2.31, locus-specific LOD = 5.47). Each additional copy of an African ancestral allele at the 6p21.1 peak was associated with an average increase in CRVE of 6.14 µm in the hypertensives, but had no significant effects in the non-hypertensives (P for heterogeneity <0.001). Further mapping in the 6p21.1 region may uncover novel genetic variants affecting retinal vascular caliber and further insights into the interaction between genetic effects of the microvascular system and hypertension.
Changes in retinal vascular caliber provide unique information regarding the structure and state of the microvasculature in the eye, possibly reflecting pathophysiological processes in the microvascular systems elsewhere in the body. Narrowed retinal arteriolar caliber has been known to be predictive of hypertension [1],[2] and coronary heart disease [3], while wider retinal venular caliber is associated with higher blood pressure [4],[5], impaired fasting glucose, diabetes, dyslipidemia [6]–[8], and risk of coronary heart disease [9]. In particular, because retinal vessels share embryological, anatomical and physiologic characteristics with cerebral vessels [10], wider retinal venular caliber bas been closely linked to both subclinical and clinical cerebrovascular diseases, including lacunar infarction, white matter lesions, clinical stroke [9],[11],[12] and cerebral hypoxia [13].
Retinal vascular caliber has been observed to vary between racial/ethnic groups. In the Multi-Ethnic Study of Atherosclerosis, African Americans and Hispanics had wider retinal arteriolar and venular caliber compared to Whites and Asian Americans, even after controlling for cardiovascular risk factors [8]. In the Atherosclerosis Risk in Communities (ARIC) Study and Cardiovascular Health Study, African Americans had larger retinal arteriolar and venular calibers than European Americans while controlling for age, gender and mean arterial blood pressure [Wong TY, unpublished data, 2009]. The underlying reasons for this racial/ethnic difference are unclear and might be related to systemic, environmental, and measurement factors [14],[15]. However, several lines of evidence provide support for genetic factors also being involved in the regulation of retinal vascular caliber. The heritability of retinal arteriolar and venular caliber was estimated to be 0.48 and 0.54, respectively, in the Beaver Dam Eye Study [16]. Results from two twin studies also showed retinal vascular caliber may be primarily determined by genetic influence with the heritability of 0.57–0.70 for arteriolar caliber and 0.62–0.83 for venular caliber [17],[18]. The observed racial/ethnic differences in retinal vascular caliber could not be fully explained by systemic and environmental factors alone, which prompted our hypothesis that differences in genetic background may partially account for differences in retinal vascular caliber across racial/ethnic populations.
To identify chromosomal regions which may harbor genes that modulate retinal vascular caliber, we utilized admixture mapping, a technique that scans the genomes in recently admixed populations, such as African Americans, for regions which may contain variants that not only differ in frequencies between the two genetically diverse ancestral populations (Europeans and West Africans in this case), but can also partially explain differences in phenotypes between populations [19]–[24]. Since the identification of ancestry-informative markers and the development of appropriate statistical methods for admixture analysis in African Americans [23], admixture mapping and subsequent fine-mapping studies have has been successful in identifying determinant genetic variants for prostate cancer [25],[26], end stage renal disease (ESRD) [27], white blood cell count [28],[29], and the circulating levels of interleukin 6 and interleukin 6 soluble receptor [30]. Differences in retinal vascular caliber between African Americans and European Americans make this an ideal phenotype to study with the admixture mapping approach.
The main hypothesis of the present study was that some alleles affecting retinal vascular caliber are present at higher frequency in Africans than Europeans. We thus conducted a genome-wide admixture mapping scan for retinal arteriolar and venular caliber using approximately 1,365 ancestry informative markers in self-identified blacks from the ARIC study. In addition, hypertension is known as one of the most important risk factors for cardiovascular and cerebrovascular diseases. Previous studies indicated the importance of interactive effects between genes and vascular risk factors, in particular hypertension, on the occurrence of cardiovascular diseases [31]–[33] and cerebrovascular disorders [34]–[36]. It has been suggested that studies investigating the role of genetic components in vascular diseases would be more effective by analyzing interaction of genetic effects with conventional risk factors [35]. Therefore, a secondary purpose of our study was to test the hypothesis that the effect of genetic variants that conferred differences in retinal vascular caliber in African Americans was modified by hypertension.
Central retinal artery equivalent (CRAE) and central retinal vein equivalent (CRVE) were measured from retinal photographs of study subjects in the ARIC study to represent the average retinal arteriolar and venular caliber, respectively (see Methods). Table 1 shows demographic and phenotypic characteristics of the 1,737 African Americans included in the present study by hypertensive status. Of them, 1,001 (57.9%) had hypertension. The estimated percentage of African ancestry (PAA) in the African-American subjects was 82.4±9.8%.
Correlations of retinal vascular caliber and genetic ancestry
The correlations between retinal vascular caliber and PAA are shown on Figure 1. CRVE was significantly correlated with PAA (correlation coefficient, ρ = 0.071, P = 0.003), while the correlation between PAA and CRAE was weaker and not statistically significant (ρ = 0.032, P = 0.182). To assess the potential interaction between genetic effects and hypertension, we examined the correlations limited to hypertensive individuals as an a priori subgroup analysis. We found that among hypertensive individuals, the correlations with PAA became stronger for both CRAE (ρ = 0.084, P = 0.008) and CRVE (ρ = 0.094, P = 0.003).
Initial admixture mapping scans
We carried out genome-wide admixture mapping scans for both CRAE and CRVE using case-only and case-control approaches, using up to 1,365 ancestry-informative SNP markers. Cases (N = 261) and controls (N = 260) for CRAE were defined as the extreme 15% of samples with narrowest caliber and the 15% with widest caliber, respectively, after adjustment for age, sex, study site, 6-year mean blood pressure, and fasting glucose level. For CRVE, the extreme 15% of samples with widest caliber was defined as cases (N = 260), while the extreme 15% with narrowest caliber as controls (N = 261). The mean CRAE was 46.2 µm (±15.3) narrower in cases compared to controls. On the other hand, the mean CRVE was 51.0 µm (±16.1) wider in cases compared to controls. Using 18 pre-specified European ancestry risk models, we did not detect significant admixture association with either CRAE or CRVE (Table S1). The genome-wide score, derived by averaging the evidence of association across all loci examined in the genome, was −0.73 for CRAE and −0.69 for CRVE (Table 2), which did not meet the thresholds of >2 for genome-wide significance [37].
Significant admixture-generated signal for retinal venular caliber in the hypertensive group
To examine whether hypertension modified the effects of genetic ancestry on retinal vascular caliber, we performed admixture mapping scans by hypertension status. Cases and controls were defined as the extreme 15% (after adjustment for the covariates as described above) in the hypertensive subset and included about 150 subjects in each group. On average, CRAE was 46.5 µm (±15.5) narrower and CRVE was 51.6 µm (±16.7) wider in the cases, compared to the controls. We found genome-wide significant evidence of associations with CRVE in the hypertensive subset (Table 2). The genome-wide score in the case-only analysis was 2.31, which meets our threshold of >2 for significance. The strongest admixture association for CRVE was observed at 6p21.1 (42.5 Mb on chromosome 6 in build 35 of the human genome reference sequence; Figure 2), with the peak locus-specific LOD of 5.47, again reaching our priori defined thresholds of >5 for significance [37]. To further correct for the multiple hypothesis testing in two subgroups, we divided our test statistic, which is the likelihood ratio that compares the model under a risk model to the null model by 2. The likelihood ratio was 105.47 = 295120.9. The likelihood ratio after corrected for two hypothesis testing was 295120.9/2 = 147560.5, corresponding to a LOD score of 5.17, which still exceeds the threshold of >5 for significance. No other locus exceeded a LOD score of 5.
To evaluate the stability of our results, we carried out a longer analysis with 10-times more iterations in our Markov Chain Monte Carlo run. We obtained a similar strength of signal with a genome-wide score of 2.28 and a peak locus-specific LOD of 5.43 at the same location. The risk model with the strongest score corresponded to a risk of 0.5 due to one copy of an European ancestral allele with the inverse risk for carrying zero copies (see Methods for the set of risk models). Further refining the risk models, we obtain a genome-wide score of 3.66 and a locus-specific LOD of 6.85 in this region.
The admixture-generated signal for CRVE in the hypertensive subset was further supported by the case-control analysis. At the 6p21.1 peak, the cases had a highly statistically significant increase in African ancestry compared to controls (case-control Z score = −5.26, P = 1.44×10−7; Figure 2). The association was nominally genome-wide significant (P = 2.88×10−4) after conservatively correcting for multiple hypothesis testing (by multiplying by 2,000 because we tested 1,000 independent chromosomal chunks in two subgroups).
We did not find any significant associations with CRAE in the hypertensive subset (genome-wide score = 0.18). The highest locus-specific LOD was 2.37, arising from chromosome 5, followed by the second highest LOD of 2.04 on chromosome 6 (Figure S1). Admixture scans were also carried out in the non-hypertensive subset, but we did not observe any evidence of association with either CRAE (genome-wide score = −0.40) or CRVE (genome-wide score = −0.21; Table 2).
Evidence of association between admixture-generated signals and continuous CRVE and interaction with hypertension
To further assess the robustness of the admixture-generated signal, we extracted the local estimate of African ancestry at the 6p21.1peak, and tested for association with continuous CRVE by hypertension status. This enabled us to increase power by including all samples in a quantitative analysis. We carried out a series of linear regression analysis, with the normal-quantile transformed CRVE (after adjusted for covariates as described above) as a dependent variable and the local ancestry as an independent variable. As shown in Table 3, local African ancestry alone was strongly associated with the transformed CRVE in the hypertensive subset (P = 2.9×10−8; Model 1). To assess whether continuous CRVE was associated with local ancestry at 6p21.1 due to their associations with global ancestry (i.e., PAA), we modeled the transformed CRVE as a function of local, global and regional ancestry. We found that the residual association of local ancestry with the transformed CRVE after adjustment for both global and regional ancestry remained significant (P = 3.9×10−6), indicating that there may be a gene in the region of 6p21.1 that is associated with CRVE above and beyond the fact that variants in this locus are highly differentiated between ancestral populations and thus correlated with global ancestry. The association was nominally genome-wide significant (P = 7.8×10−3) after correcting for multiple hypotheses tested (by multiplying by 2,000). The results were similar when CRVE was additionally adjusted for other covariates (Model 2), including high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol and plasma triglyceride levels, body mass index (BMI), smoking, and alcohol consumption. We estimated that each additional copy of an African ancestral allele at the 6p21.1 peak was associated with a CRVE increase of 0.37 Z-score units on average (equivalent to ∼6.14 µm).
In contrast, in the non-hypertensive subset, the local ancestry effect at the 6p21.1 peak on CRVE was weak and did not reach significance (Table 3). The effect of local ancestry showed significant heterogeneity (P<0.001) between the hypertensive and non-hypertensive groups, which was in line with the results of the above dichotomous admixture scans.
95% credible interval for the CRVE loci
Given the significant statistical evidence for peak at 6p21.1, we constructed 95% credible interval (CI) for the loci identified. The 95% CI spanned from 40.8 to 43.9 Mb on build 35 of the human genome reference sequence (Figure S2). The locus-specific LOD score and the association of the CRVE to local ancestry for the SNPs located near and within the 95% CI are presented in Table S2.
We used admixture mapping to search for genomic regions that may account for inter-individual variations in retinal vascular caliber. We found evidence for association with retinal venular caliber at 6p21.1 in hypertensive African Americans and observed concordant results when venular caliber was examined as a continuous variable, with higher levels of African ancestry being significantly associated with wider retinal venular caliber. The significant evidence of association with the local ancestry at the 6p21.1 peak was above and beyond the contribution of both global and regional ancestry. Methodologically, these results are interesting in that subset analysis was required in order to detect the association. We note that subsets analysis has previously been very successful in admixture mapping. For prostate cancer, the chromosome 8q24 locus was not detected until the analysis was limited to a subset of individuals with a younger age at diagnosis [25]. For ESRD, the admixture signal to be much stronger among non-diabetic ESRD (mainly hypertensive ESRD) only, compared to diabetic ESRD [27]. Subsequent fine mapping identified genetic variants strongly associated with both prostate cancer [26] and non-diabetic ESRD [27]. We hope to follow up the present analysis with successful fine-mapping as well.
Our findings in persons with hypertension in the subgroup analysis imply that genes associated with hypertension may have exerted their effects on retinal vascular caliber. While we cannot exclude the possibility of a chance finding, we were able to show consistent results in the local ancestry analysis, which included the total population. Furthermore, from a physiological perspective, our finding that there is a genetic association with retinal venular caliber specifically in people with hypertension is sensible. Hypertension is known to have profound effects on the retinal microcirculation [38]–[40], and may induce gene expression relevant to the modulation of retinal vessels (see further discussion below) [41]. Our findings are also in line with previous studies in other vascular diseases that indicated hypertension exaggerates the effects from genetic factors [31]–[36].
In hypertensive persons, we detected significant genetic association for retinal venular caliber, but not arteriolar caliber. Because retinal arterioles and venules likely possess distinct genetic determinants [42], there may be no common genetic variants with a strong effect accounting for differences in retinal arteriolar caliber between European and African populations. Moreover, a diminished capability of retinal arterioles to remodel because of progressive sclerosis and rigidity of arteriolar vessel walls with age [43], may have precluded a degree of change in arteriolar caliber equal to that observed in venular caliber.
To our knowledge, there have been only two prior studies examining the genetic basis of retinal vascular caliber with a genome-wide approach, and both of them used linkage analysis [18],[45]. By genotyping 385 microsatellite markers in the Beaver Dam Eye Study, Xing et al. [45] found several loci for CRAE and CRVE, with the most significant loci at 3q28 (empirical P = 1.2×10−4) and 8q21 (empirical P = 2.9×10−3), respectively. A recent linkage analysis in the Australian Twins Eye Study identified 8p23.1 (LOD = 2.24) and 2p14 (LOD = 2.69) as suggestive loci for CRAE and CRVE, respectively [18]. Although findings of the two linkage analyses were not replicated in our study, possibly due to differences in study design and populations, all three studies provide lines of evidence that structural changes in the microvasculature of retina may have genetic determinants.
One major concern of the present study is a potential measurement error on retinal vascular caliber itself, which has been suggested to account for some of the observed racial/ethnic difference in retinal caliber [15]. A recent report suggested that retinal pigmentation could be a source of error in the computer-assisted methods to measure retinal vascular caliber from photographs [15]. The study reported that arteriolar and venular calibers were significantly wider in East Asian children than their white counterparts. However, when the analysis was confined to children with dark brown iris (a surrogate of retinal pigmentation) only, the differences between racial groups were less pronounced. Nevertheless, measurement errors are less likely to bias results in the present study for the following reasons. First, in the ARIC study, the retinal vessel edge was not detected based on computer-generated pixel density curve, but located manually by graders [46]. We believe the manual grading of retinal vascular caliber would be less prone to bias than computerized grading schemes, yet this remains to be proved. Second, genetic ancestry was shown to be significantly correlated with human pigmentation [47]. Although we did not measure skin or retinal pigmentation in the ARIC study, the inclusion of global ancestry as a covariate in our local ancestry analysis (Table 3) may thus provide an alternative way to adjust for the differences in retinal pigmentation.
The 95% CI for the 6p21.1 locus, a ∼3.1 Mb region, contains genes that may have biological relevance to the development and modulation and of retinal vessels (Figure S2). One such gene is the vascular endothelial growth factor (VEGF) gene. VEGF is an endothelial-cell selective mitogen intimately associated with vasculogenesis, angiogenesis and vascular permeability. In the retina, VEGF plays a crucial role in the induction of retinal vasculature and its expression is regulated by hypoxia during embryonic development [48]. Moreover, animal experiments showed that VEGF acts as a survival factor for newly formed retinal vessels [49], and it continues to be produced by retinal astrocytes and pericytes in the vicinity of retinal vessels in adults [50]. Interestingly, mechanical stretch on retinal vessel endothelium induced by systemic hypertension could increase the expression of VEGF and its receptor [41]. Further mapping work is needed to determine whether variants in the VEGF gene indeed contribute to variations in retinal vascular caliber. If proven, this may help explain why we detected the association at 6p21.1 only in hypertensive persons.
In addition to VEGF, there are two other genes in the 95% CI that may potentially be associated with retinal phenotype: peripherin 2 (PRPH2/RDS) and guanylate cyclase activator 1A (GUCA1A), both of which are also expressed in retina [51],[52]. GUCA1A plays a role in the recovery of retinal photoreceptors from photobleaching [52]. PRPH2/RDS is mainly located in the outer segment of both rod and cone, and defects in this gene are associated with retinal degenerations [51]. VEGF appears to be the strongest candidate gene based on its known function. However, it does not exclude the possibility that the admixture-generated signal is due to other genes.
The human leukocyte antigen (HLA) loci, located on chromosome 6p21.3 and about 10 Mb away from the 95% CI, are gene-rich and highly polymorphic [53]. The HLA region has been shown to play an important role in multiple disease susceptibility, particularly in autoimmune and infectious diseases [54]. HLA alleles are strongly associated with many neighboring SNPs, sometimes located at a considerable distance from the HLA allele with the linkage disequilibrium (LD) extending several Mb [55]. It remains to be determined whether the HLA alleles and the alleles in the 95% CI are in LD and may thus be associated with retinal venular caliber.
In summary, using a genome-wide admixture mapping scan in 1,737 African Americans, we detected a risk locus influencing retinal vascular caliber in hypertensive individuals at 6p21.1, where the association between local ancestry and retinal venular caliber was strong, suggesting the presence of a genetic effect beyond the effects of global ancestry. Follow-up fine mapping or haplotype tagging across the peak will be necessary to determine whether this region harbors genetic variations that may interact with hypertension to modulate retinal venular caliber. Understanding the genetic basis of retinal vascular caliber may provide novel insight into the development and remodeling of the microvasculature in the brain and elsewhere in the body.
Ethics statement
This study was conducted according to the principles expressed in the Declaration of Helsinki. All sample collections were carried out according to institutionally approved protocols for study of human subjects and written informed consent was obtained from all subjects.
Study populations
Subjects of the present study were from the 2,997 African-American participants of the ARIC study at the third examination. The ARIC study is a prospective epidemiologic study that examines clinical and subclinical atherosclerotic disease in a cohort of 15,792 persons (including 4,266 African-Americans), aged 45 to 64 years at their baseline examination. Participants were selected by probability sampling from four U.S. communities: Forsyth County, NC (12% African American); Jackson, MS (100% African American); the northwest suburbs of Minneapolis, MN (<1% African American); and Washington County, MD (<1% African American). The sampling procedure and methods used in ARIC have been described in detail elsewhere [56]. Participants self-reported their ethnicity. The baseline examination (visit 1) took place from 1987 to 1989, a second examination (visit 2) from 1990 to 1992, and a third examination (visit 3) from 1993 to 1995. Retinal vascular calibers were measured at visit 3. Data from visit 3 were used for the present analysis.
The final sample for the present analysis included 1,737 African Americans after excluding the following samples (N = 1,267): 1) African-American subjects who lived in Minneapolis, MN, or Washington County, MD, or 2) did not consent to genetic studies or did not have DNA samples available, 3) samples that were not genotyped successfully or that failed to pass quality control (see "Elimination of problematic samples"), 4) subjects who had no retinal photographs, ungradable photographs or retinal vascular occlusions, and 5) subjects who had missing data on the covariates used in the main admixture mapping scans (see "Admixture mapping").
Measurement of retinal vascular caliber
The retinal photography procedure and its assessment have been described in detail elsewhere [46]. Briefly, a 45-degree retinal photograph of one randomly selected eye of each participant was taken at visit 3 following 5 minutes of dark adaptation. This photograph was centered on the region of the optic disc and the macula and was taken using an autofocus camera.
Trained graders who were masked to participant measured the calibers of all arterioles and venules coursing through a specified area surrounding the optic disc according to a standardized protocol [46]. Individual vessel measurements were combined into summary indices: CRAE and CRVE. These indices represents average retinal arteriolar and venular caliber of the eye after taking into account the branching patterns. These measurements of retinal vascular calibers are reliable, with generally high intragrader and intergrader reliability coefficients (0.84 and 0.79, respectively) [46],[57].
Assessment of systemic factors
Current blood pressure was defined as measurements at the time of retinal photography at visit 3, and 3- and 6- year past blood pressure was defined as measurement taken at visit 2 and visit 1, respectively. Mean arterial pressure was defined as two thirds of diastolic plus one third of systolic blood pressure. Mean arterial pressure across the three visits was averaged to obtain the 6-year mean arterial pressure. BMI was calculated as weight (in kg)/height (in meters) squared. Blood collection and processing followed a standard protocol [58]. Fasting glucose was assessed by a modified hexokinase/glucose-6-phosphate dehydrogenase procedure. Total plasma cholesterol and triglyceride were measured using enzymatic methods [59]. LDL cholesterol was calculated [60], and HDL cholesterol was measured after dextran-magnesium precipitation of non-HDL lipoproteins [58]. Cigarette smoking and alcohol consumption were ascertained from a questionnaire interview. Hypertension was defined as current systolic blood pressure ≥140 mm Hg, diastolic pressure ≥90 mm Hg, or self-reported use of medications for high blood pressure during the 2 weeks preceding the clinic examination at visit 3.
Genotyping for the ancestry informative markers
We genotyped a total of 1,536 SNPs included in the phase 3 admixture panel [28,61]. This panel was constructed by using the panel of ancestry informative markers previously published by Smith et al. (phase 1 panel) [24], improving this panel by mining new ancestry informative markers from the data sets of Hinds et al. [62] and the Phase 2 International Haplotype Map [63], and then validating them to confirm that they were indeed ancestry informative. Genotyping was performed by the Center for Inherited Disease Research (CIDR, Johns Hopkins University, Baltimore), using the Illumina BeadLab platform [64]. The ARIC study has a rigorous quality control program, including blind duplicates. Many genotypes in duplicates were obtained using the Illumina BeadLab technologies in ARIC African-American participants, and CEPH and Yoruban samples. The mismatch rate among duplicate genotypes was 0.1%.
Estimates of allele frequencies in ancestral populations
We used previously published genotyping data to estimate the frequency of each SNP in West Africans and Europeans [24],[25],[64]. We used only those SNPs for which we were able to obtain data from both West African (Yoruba) and European American (CEU) populations from the International Haplotype Map. For SNPs in the phase 1 panel, we also added additional genotyping data from African and European samples, which was the same as the data collected in Smith et al. 2004 [24].
Elimination of problematic samples
After genotyping, samples were eliminated based on the following criteria: 1) samples with low (<94%) call rate, 2) samples showing gender mismatch between self-reported data and genetically estimated gender based on 50 markers on the X chromosome, and 3) duplicate samples (defined as >75% match in the genotypes between two samples. Moreover, we used built-in data checking programs in the ANCESTRYMAP [23] software to exclude samples with an apparent excess or deficiency of heterozygous genotypes compared with the expectation from the individuals' global ancestry. An apparent excess of heterozygous genotypes (defined as the Z-score >10) usually indicates the individuals have parents with divergent ancestries (for example, one parent who is entirely of European ancestry) and such individuals nearly always have estimated European ancestry close to 0.5 [23].
SNP quality filters
To decrease the likelihood of false-positives in our admixture scans, we applied a series of filters that had the goal of detecting and removing any SNPs with problematic genotyping, as described previously [24,30,61,66]. First, SNPs were dropped if there were atypical clustering patterns, ill-defined clusters, or relatively low genotyping success rate (95%). This left us with 1,416 SNPs (all with genotyping call rate >97%). We then applied three previously described filters to further eliminate SNPs from the analysis [66]. 1) We eliminated SNPs (N = 15) if they did not meet the requirement for Hardy-Weinberg equilibrium (P>0.01) in both ancestral West African and European populations. 2) We applied a "freqcheck" filter that examined whether the observed frequency of a SNP in African Americans was statistically consistent with being a mixture of the frequencies observed in the West Africans and European American samples that we used to represent the ancestral populations [23]. 3) Lastly, we applied a "ldcheck" filter that for each sample, iteratively eliminated SNPs that were less informative (in terms of the information content about ancestry) until none were within 200 Kbs of each other or in detectable LD with each other in the ancestral West African or European populations [23]. After imposing these requirements, 1,365 SNPs were left for analysis.
Estimating genome-wide ancestry genetic ancestry
Using the ANCESTRYMAP software [23], we estimated a global ancestry for each individual, as indicated by PAA. ANCESTRYMAP uses a Markov Chain Monte Carlo approach to account for uncertainty in the unknown parameters (including SNP allele frequencies in the West African and European ancestral populations, the number of generations since mixture, and the average proportion of ancestry inherited from ancestral populations) that emerge from the Hidden Markov Model analysis. All Markov Chain Monte Carlo runs used 100 burn-in and 200 follow-on iterations, as recommended [23], except for one longer run of 1,000 burn-in and 2,000 follow-on iterations, which we used to check the stability of our results.
Admixture mapping
We used the ANCESTRYMAP software [23] to search for genomic regions associated with an increased percentage of either European or African ancestry. The main dichotomous admixture scans used the values of retinal vascular caliber adjusted using the following covariates: age, sex, study sites (Forsyth County or Jackson), 6-year mean arterial blood pressure and fasting glucose level, because the latter two systemic factors were both significantly correlated with PAA (both P<0.01) and known to be associated with retinal vascular calibers [4],[7],[8]. For the tests for associations of the local ancestry, we additionally adjusted for other cardiovascular risk factors.
For the purpose of this dichotomous admixture analysis, study participants were ranked by the adjusted values for each trait. For CRAE, the 15% of individuals with the lowest values were defined as cases, and the 15% with the highest values as controls. For CRVE, conversely, the 15% with the highest values for were defined as cases, and the 15% with the lowest values as controls. Because ANCESTRYMAP uses Bayesian statistics, a prior distribution of risk models is required [23]. We tested 18 pre-specified European ancestry risk models to assess overall evidence of association by averaging across all models. The first 6 models used 0.4, 0.5, 0.67, 1.5, 2.0 and 2.5-fold risks of being a case due to inheritance of one copy of an European ancestral allele, with a risk of 1 for carrying zero copies of an European ancestral allele. The next 6 models used the same risk set as the first for carrying one copy of an European ancestral allele, whereas the risk of carrying zero copies were set to the reciprocal of the risks for carrying one copy. The last 6 models specified that inheritance of either one or two copies of an European ancestral allele had a risk of 1, but carrying zero copies had risks of 0.4, 0.5, 0.67, 1.5, 2.0 and 2.5. By convention used in the manuscript, a risk <1.0 for inheritance of one copy of an European ancestral allele at a given locus represents a risk model where European ancestry decreases risk relative to African ancestry. This set of models reflects the hypothesis that European ancestral alleles are less likely to confer risks but also tests for the alternative possibilities [23].
ANCESTRYMAP provided two scores to assess statistical significance: a locus-specific score and a case-control score [23]. A locus-specific score was obtained in cases (case-only analysis) by calculating the likelihood of the genotyping data at the SNPs at the locus under the risk model and comparing it to the likelihood of the genotyping data at the SNPs at the locus assuming that the locus is unassociated with the phenotype. The ratio of these two likelihoods is the "likelihood ratio", and the log-base-10 of this quantity is the "LOD" score. A locus-specific LOD score of >5 has been recommended as criterion for genome-wide significance [37]. To obtain an assessment of the evidence for a risk locus anywhere in the genome, we averaged the likelihood ratio for association across all loci in the genome, and took the log10 to obtain a "genome-wide score". We interpreted a genome-wide score >2 as significant [37].
A case-control score was calculated by comparing locus-specific deviations in European ancestry in cases versus controls at each locus across the genome. This score tests whether any deviation in ancestry from the genome-wide average is significantly different comparing cases with controls [23]. If there is no locus associated with phenotype, the case-control score is expected to be distributed approximately according to a standard normal distribution. For loci identified by the case-control score, the level of genome-wide significance was defined as a Z score >4.06 or <−4.06, corresponding to an uncorrected nominal P<5×10−5, or a corrected nominal P<0.05 after conservatively correcting for 1,000 hypotheses tested (approximately equals the number of independent chromosomal chunks assigned to either African or European ancestry).
Assessing association of the retinal venular caliber to local ancestry at admixture-generated signals
The main admixture scans were based on a dichotomous phenotype (i.e., cases and controls) in a subset of our samples. To check whether the results were consistent in our entire sample, we used the ANCESTRYMAP software to obtain local estimates of African ancestry at the admixture peak [23], and then assessed the association of the local ancestry with retinal venular caliber as a continuous trait using linear regression models. Using ANCESTRYMAP, we also obtained regional estimates of ancestry based on the SNPs on chromosome 6p in the admixture panel. In addition to the five covariates used in the main admixture scans, CRVE was further adjusted for HDL cholesterol, LDL cholesterol and plasma triglyceride level, BMI, smoking, and alcohol consumption, all of which covariates have been shown to affect retinal vascular calibers [6]–[8],[14]. We then performed a normal-quantile transformation for CRVE to ensure normality. In the linear regression models, the transformed CRVE was used as a dependent variable and the local estimates of ancestry as an independent variable. To determine whether there was evidence of residual association with local ancestry after adjustment for global and regional ancestry, we included each individual's PAA and estimated regional ancestry on chromosome 6p as covariates in the regression models. This enabled us to increase power by including all samples in a quantitative analysis, rather than using only a subset of samples with the highest 15% and lowest 15% values in the dichotomous admixture scans described above. To determine whether the association between the local ancestry and CRVE differed significantly by hypertension status, Z tests were used to compare the difference in the regression coefficients obtained from the hypertensive and non-hypertensive groups.
Credible interval for the position of a genetic locus
To determine a 95% CI for the position of a trait locus, we obtained the likelihood ratio for association at each marker on the chromosome where we identified an association. This provided a Bayesian posterior probability for the position of the underlying causal variant assuming a flat prior distribution across the region for the position of the trait locus. We defined the CI as the central region of this peak containing 95% of the area.
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PLOS Genetics
2010 Číslo 4
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Walnut Hole Pendulum Clock
Wood Clock
Created by Steve Uren
Created from a single piece of black walnut, the Hole Pendulum Clock is stunning in any setting. The white swinging pendulum is mesmerizing. This clock features white metal hands and pendulum. It hangs from a single screw and is set out just slightly from the wall. Requires two AA batteries (not included).


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IS recruit and daughter back in Ireland
An Irish citizen who became an Islamic State bride has been arrested after arriving back in Dublin.
Lisa Smith and her daughter travelled from Turkey after being deported, arriving in Ireland on Sunday.
She was arrested on arrival and it is expected she will now be interviewed by police about suspected terrorist offences.
Plans have also been made for the care of her two-year-old daughter, who was born in Syria, but is an Irish citizen.
Miss Smith is a former member of the Irish Defence Forces.
In a statement, Irish Minister for Justice Charlie Flanagan said: "This is a sensitive case and I want to reassure people that all relevant state agencies are closely involved."
Irish state broadcaster RTÉ has posted footage on social media of her being escorted by gardaí (Irish police) on the runway in Dublin.
The BBC interviewed her in Syria earlier this year.
She said was not involved in fighting and did not train girls to become fighters.
She also claimed she had been visited more than once by the FBI for questioning, and agents had taken her fingerprints and DNA.
Ms Smith had been living with her daughter in a Syrian refugee camp.
The taoiseach (Irish prime minister) Leo Varadkar had previously said she would "certainly" be investigated if she returned to Ireland.


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Of Interest: Elizabeth Warren Devastates Hillary Clinton With Must-Hear Corruption Story (TJDS)
Posted by juanbook at 08:00 No comments:
Labels: Corruption, Elizabeth Warren, Hillary Clinton, Juan Delgado, juanbook, money out of politics, Of Interest, Politics, Politics & Corruption, The Jimmy Dore Show, The Young Turks, YouTube
Found Coolness: A Group Of Alpine A110s
All your A110 are belong to Juan...
Found Here: Petrolicious Facebook
Posted by juanbook at 09:00 No comments:
Labels: Alpine, Alpine A110, Car-ifornia, Classic Car, European, Facebook, Found Coolness, French, Juan Delgado, juanbook, Pertoliciuos, Renault
Funny: Ted Cruz's Face
The distaste for Cruz even extends beyond the US: Germans say Backpfeifengesicht, meaning "a face in need of a good punch."
Ted Cruz Provides Detailed Response To Moderator's Question About Why His Face So Fucking Infuriating
"Ever since I was a child, I have had a weaselly, piece-of-shit face that you can't help but want to hit, and that's never changed—how many other candidates on this stage can say that?" said Cruz, adding that oftentimes when he looks in the mirror, even he wants to drive a screwdriver through his eyes so he never has to see his stupid, boxy head and waggling, doughy chin ever again. "Let me be clear: When voters look at my shit-eating, smug-as-fuck smirk, they can't help but want to wipe it off by grabbing me by my waxy hair and smashing my face repeatedly into a tabletop. I believe that's something every American can agree on." At press time, Cruz's explanation was cut off by Donald Trump loudly claiming that none of the other candidates' faces could even come close to how leathery and enraging his is.
Posted by juanbook at 16:30 No comments:
Labels: Creepy, Face, Funny, Neurologist, piece-of-shit face, Politics, Raw Story, Ted Cruz, The Onion, Unsettling, weaselly
Found Coolness: Centriphone
Nicolas Vuignier 100% shot this video with his iPhone 6 and some string and almost two years of tinkering and tweaking he finally achieved the result he was looking for. If the result he was looking for was awesomeness, he succeeded.
Posted by juanbook at 07:30 No comments:
Labels: 6, Armature, Centriphone, Found Coolness, iPhone, Juan Delgado, juanbook, Nicolas Vuignier, Ski, Skier, Snow, Spinning, String, YouTube
The Cali' Experience: The Next Phase (The Cannery)
Is this the place to put down our roots?
Homes have gotten a little more expensive since this video was made but the info on the community is still pertinent.
Here we go again!
This video shows a lot of what I have grown to like about Davis.
I run through this neighborhood whenever I am not working and it is still there and so much more mature. Homes in this neighborhood rarely come up for sale, maybe the cannery will be similar in the future.
Posted by juanbook at 01:31 No comments:
Labels: CA, Davis, Juan Delgado, juanbook, New Neighborhood, The Cali' Experience, The Cannery, The Empty Seat, The Next Phase, Village Homes, YouTube
Found Coolness: Jake Weidmann Master Penman
Respect the efforts of a true artisan, weird it was sponsored by Coors... but hey, it gets it's message out.
Posted by juanbook at 22:00 No comments:
Labels: Banquet, Coors, Found Coolness, Jake Weidmann, Juan Delgado, juanbook, Master Penman, Uproxx
Random: Ubu
Posted by juanbook at 13:02 No comments:
Labels: Bark, Good dog, Juan Delgado, juanbook, Random, Sit Ubu sit, Ubu Productions, YouTube
Funny: Obama Compiles Shortlist Of Gay, Transsexual Abortion Doctors To Replace Scalia (The Onion)
Obama Compiles Shortlist Of Gay, Transsexual Abortion Doctors To Replace Scalia"These are all exemplary candidates with strong homosexual values and proven records of performing partial-birth abortions, but am I missing anyone?" Obama reportedly asked himself while reviewing his list of queer, gender-nonconforming, feminist Planned Parenthood employees, all of whom were also said to be black immigrants.
Posted by juanbook at 11:00 No comments:
Labels: Abortion Doctors, Compiles Shortlist, Funny, Gay, Juan Delgado, juanbook, Obama, Replace Scalia, The Onion, Transsexual
Found Coolness: WWJD?
Found Here: My Inner Child is a Drunken Wench (Facebook)
Posted by juanbook at 12:00 No comments:
Labels: chasing people with a whip, flipping over tables, Found Coolness, if anyone ever asks you what would jesus do, is within the realm of possibility, Juan Delgado, juanbook, Whip, WWJD
Music: In Defense of the CD (Rolling Stone)
I never got rid of my CDs, though they have been sitting in a non-air conditioned storage unit for the last three summers in Vacaville where it can sometimes hit 110+ degrees (low humidity though) and could likely be damaged I'll find out at some point. Just reading this article has by rolling stone has made me want to go get them today.
In Defense of the CD
"I know it sounds insane at this point in time, but it wasn't that long ago – two decades, more or less – that many of us actually lauded the arrival of those shiny round discs. Our vinyl was growing scratchy and warped, and cassettes, for all their portability, had serious audio flaws and could break easily. Those gleaming sonic coasters weren't just smaller than LPs; they made music old and new sound clear and clean. Proud anti-digital warrior Neil Young will disagree, but it was time for an audio upgrade, and what we heard – clarity of sound, separation of instruments – was damn impressive in those early CD days."
"Right now, nobody seems to remember any of those upshots. In fact, people don't seem to be just tired of the CD; it feels as if they're actively calling for its demise. When vinyl began dying off in the early Nineties, many people, me included, mourned its passing on many levels. But we didn't dance in the streets that it was in its death throes, the way so many seem to be doing these days with the CD. A friend recently called to ask what he should do with his shelves of discs, since many of his friends were strongly urging him to chuck them. That's right: People were actually saying he should throw his CDs in the garbage. (You can recycle them, you know.)"
Posted by juanbook at 17:30 No comments:
Labels: Audio CD, Audiophile, In Defense of the CD, Juan Delgado, juanbook, Music, Rolling Stone
Current Events: Groundhog Day (Bill Murray Chekhov Speech)
"When Chekhov saw the long winter, he saw a winter bleak and dark and bereft of hope. Yet we know that winter is just another step in the cycle of life. But standing here among the people of Punxsutawney and basking in the warmth of their hearths and hearts, I couldn't imagine a better fate than a long and lustrous winter. From Punxsutawney, it's Phil Connors, so long."
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Ricky started following are import folders synced to cloud?, Unable to access Google Sheets through attached link, New Web Experience Beta now Available and and 4 others
Unable to access Google Sheets through attached link
Ricky replied to BarthSiemens's topic in Evernote for Android IssuesI'm having the same problem with Google docs. This is happening on different Google docs as well. Wi-Fi is connected properly. I even have the issue after completely reinstalling. I've sent a support ticket to Evernote. There is also no issue with file names issue. Just looks like this feature is completely broke.
New Web Experience Beta now Available
Ricky replied to Chantal Leonard's question in Evernote Web Client RequestsWhen will the most vital and basic feature of moving notebooks be available? I understand that it is a beta BUT THAT IS THE MOST BASIC FEATURE. Moving notebooks should of been enabled before the beta was even announced. Now 4 months later and still can't move notebooks. I like the look of the new interface but you can't even do something as simple as ORGANIZING. ?
Sorry I was referring to the Android app. It's really very minor anyway but it would be nice to have screenshot feature built into the app in case the web clipping produces poor results.
Now if they introduce actual built-in task management I will be so excited. BUT it has to be on all platforms! They better not dare introduced some awesome task management feature that's only available on Windows. I use my mobile device more than my computer and a lot of companies out there still don't get this. Since Evernote switched to Google for their cloud services, I have seen improvements with syncing and speed. Tables introduction in Windows app was a good update, but I would still like to see that in the Android app. My big areas of disappointment are: Web clipping is unpredictable and there is no built-in screenshot option. Really no changes for quite some time for inking. And the Windows app has too much lag and freezes every now and then. Also more formatting options in the Android app. I still feel that Evernote is the best note taking app out there. One note and all the other note taking apps have not given me really any good reason to switch.
They have to make an improvement to the inking system on all platforms, that would be a great start. I just hope that we hear an update or blog posts from the leaders soon. But even with this news, I'm still sticking with Evernote. This entire year there has been NOT ONE big update to the Windows client. It is laggy and freezes for a short time. But I still feel that Evernote is the best note taking app out there. Onenote just annoys me and there are unnecessary steps to complete certain tasks. Syncing can be a mess if you change notebooks in Onenote. And Evernote obviously has the best integration with platforms and other apps. I think people who are migrating from Evernote to Onenote will seriously regret it. Evernote just needs more polish. Anyway I think we deserve to hear something from leadership about the future of Evernote in the next couple of months. In my opinion, 2019 has to be a year of big improvements and new features.
Change encryption passphrase?!
Ricky posted a topic in Evernote for Windows IssuesHow in the ? do I change my encryption passphrase?! This is so ? stupid that it has to be this difficult. I've deleted the note, recopied the text, uncheck the remember passphrase, exited Evernote and it is still stuck on that passphrase. Do I have to reinstall Evernote to reset this? What if one screws up on his passphrase? ?!!
Attachments cannot be edited
Ricky replied to Lutherian's topic in Evernote for Android IssuesI'm having the same resource not changed error when editing an image in a separate app on Note 8. I've had the same issue on my Note 5. I've had the same issue on my HTC DNA. Hopefully there will be a fix for this THIS YEAR. Maybe there working on built in editing, PLEASE PLEASE.
Resource not changed issue longtime issue
Ricky posted a topic in Evernote for Android IssuesI know this has been reported several times to Evernote so I'm confused why it hasn't been fixed yet. So Evernote fails to give us any valuable editing after a document is scanned. Multiple times, the image is not properly cropped by Evernote. And I even have the document on a black wood desk! So I use the edit image feature. I then select Snapseed and crop in the image. After pressing done in snapseed, I go back to Evernote and receive the message resource not changed. The only app that seems to work with Evernote is Pixlr. Has anyone found a work around? Has anyone found an app that works well with Evernote. In addition to not working with well known Snapseed, it doesn't work with Adobe Photoshop app. The fact that it fails with SEVERAL apps is a problem on Evernotes end. The next version of Android better have more advanced editing features for images that are scanned! I like Evernote and have been with them for years but if they don't start taking several things seriously (scanning & pen improvements), LIKE THIS YEAR (OK BY 2019 SINCE EVERNOTE TAKES FOREVER WITH UPDATES), then I'm concerned about their future. ,Ricky
are import folders synced to cloud?
Ricky posted a topic in Evernote for Windows IssuesSo I'm using the awesome feature of automatically importing folders into Evernote. What happens when I uninstall Evernote? Do I have to re-add every folder again? I don't see any backup or export option. ,Ricky
"Clip failed" error on Android for "Clip Full Article"
Ricky replied to Greg H.'s topic in Evernote for Android IssuesLooks like the update fixed it since I'm not running into the issue on my stable, recent version of the Android app. I tried Chrome and Firefox on android and got the same web clipping results. I really wish the clipping was more intelligent and would automatically remove all the excess junk, like ads and links from the web page. I would recommend using Gboard keyboard since it makes it easier to go through the page and remove unnecessary text. And this is mostly for those who are new to Evernote: I know it is stating the obvious but if you run into an error, the forums are great for updating others but you would receive quicker results by: send your activity log an export of the note's enex file screenshot or screen recording. I recently ran into an error where Evernote was not responding to decrease indent button or shortcut. Support was able to see some type of corruption occurring in the line of text. And obviously ifyou contact support first, then you can post on the forum your updates and that would save them time. ,Ricky
decrease indent will not work!
Ricky replied to Ricky's question in Evernote for Windows Requestshmmm, well I check out the beta version and see if there are enhancements, wouldn't hurt, thanks.
focus more on Evernote Web
Ricky replied to Ricky's question in Evernote Web Client RequestsI'm just irritated with the errors that I'm running into. I'm being more sarcastic and dramatic than anything. Anyway, hopefully 2018 will be the year for some good improvements for Evernote.
focus more on Evernote Web
Ricky posted an idea in Evernote Web Client RequestsWhen will Evernote Web have more robust organization features like the Windows client? Evernote Web provides a smoother, more bug free experience. The Windows program constantly creates lag when typing, possibly due to syncing in the background but I don't experience that I the web version. Also, basic features are not free from bugs! Randomly, I can't even freakin decrease the indent! Tables produce weird errors too. Also tables in the web version are so basic! If you can't get the Windows application right, then just discontinue it. Other companies have created web only versions and they work great. For example Google Docs, and Google Sheets. Maybe Evernote should just consider dropping their desktop clients. That way more focus and energy can be put into the web version. Offline support? Google sheets and Docs does it. Google Keep even has hand writing support in their web app. Anyway I really like Evernote but the Windows client is going no where. ,Ricky
decrease indent will not work!
Ricky posted an idea in Evernote for Windows RequestsSo here are the steps that lead to issue: 1. after typing, increase line indent 2. next line will not decrease indent when I select decrease indent and use the shortcut. NOTHING HAPPENS. I can increase the indent but I can't decrease it. So damn annoying! Is anyone else experiencing this issue? This is really ridiculous. This is basic stuff that Evernote can't get right. It has happened repeatedly. I will let the developer know about this shortly of course. ,Ricky
Evernote's Tables are a mess
Ricky posted a topic in Evernote for Windows IssuesHow difficult can it be to get a table to work reliably? I have two columns and I'm trying to create a useful hourly planner but Evernote is letting me down. I have the first part of the table created and then want to do a simple copy and paste. But no, Evernote has to insert a random column! I was able to re produce this bug every time using the following steps but it seems to be random: create 3 x 4 table perform merger of cells (see below image) delete 4th column copy all cells press tab to create new row paste cells to create second segment What could be possibly happening is that Evernote is thinking that when you paste it is going off of the original table settings before deletion. And also you can see that it doesn't even let you delete the extra column! Hopefully Evernote reads this to save me some time but I'll report this bug when I get a chance. Evernote is an amazing one stop service for planning and notes so it is a bummer when running into this type of error.


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Oct 26, 2018 - Delfin II
Today we arrived at the heart of the Pacaya-Samiria Natural Preserve. To maximize our time in this magnificent place, we left Delfin II by skiff at 5:30 in the morning. We were very lucky to have a completely overcast sky, which made our outing very pleasant. Not only was the temperature very nice, but also the light for photography was soft and perfect.
We traveled fast, stopping only for wildlife that was new for us, which we had not seen elsewhere on this expedition. Our first stop was for a small troop of red howler monkeys. These beautiful primates occasionally filled up the atmosphere with their amazingly loud calls. Some other very interesting stops were thanks to findings like jabiru storks, a family of giant river otters, several small flocks of blue and yellow macaws, and several large black cayman.
We had breakfast way out in the middle of the wilderness. An old house which was once used by an Ex-President of Peru for his fishing expeditions now belongs to the preserve. This is where we used the outside porch to enjoy the food and beverages that our galley crew prepared on the ship, and brought it all here for us!
After a marvelous morning of rich wildlife viewing, we came back to Delfin II for lunch. After some time to rest and enjoy the navigation through the Ucayali River, we had a wonderful presentation about jaguars by Carlos Navarro.
We ended the day with a walk that we have done very few times. We explored an old road that is located about five hours downriver from the mouth of the Pacaya. The place may or may not have a name, but it seems to lead to some distant community deep in the jungle. We started out late in the day, to have an introduction to the Varzea environment during the day, and a night walk for the latter half of our walk.
We had an amazing night walk! Some our sightings included at least four kinkajous running around up in the trees, a medium size Amazon tree boa, an arboreal pit viper, several species of bats, tarantulas, scorpions, and several different tree frogs. We saw all of this while surrounded by majestic old trees and nocturnal jungle sounds.
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