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The Federal Maritime Commission acknowledges China's objection to P3 Network
At the same time, however, the FMC says future carrier collaborations should not be ruled out
in the News
State of Logistics 2016: Pursue mutual benefit California's ports may face new political pressures during "Peak Season" CEMA forecasts 7.5% growth in conveyor industry for 2017 Schneider National officially rolls out IPO U.S.-NAFTA freight up again in January, reports BTS More NewsHaving given the P3 Netork its blessing some time ago, The Federal Maritime Commission (FMC) has acknowledged China's objection to the alliance.
At the same time, however, the FMC says future carrier collaborations should not be ruled out.
"Ocean carrier vessel space alliances offer the potential benefit of cost savings and environmental efficiencies that come from coordinated deployment of newer, larger vessels," says FMC chairman, Mario Cordero. "The FMC, in evaluating such agreements, will continue to balance those benefits with the potential harm from a concentration of decision-making power in terms of port coverage, sailing schedules, and necessary trade lane capacity.
As reported here last week, the FMC's Chinese regulatory counterpart, the Ministry of Commerce (MOFCOM), nixed the P3 Network Vessel Sharing Agreement, calling it "uncompetitive."
The agreement between A. P. Moller-Maersk A/S, CMA CGM S.A., and MSC Mediterranean Shipping Company, S.A. would have authorized the parties to share vessels and engage in related cooperative operating activities in the trades between the U.S. and Asia, North Europe, and the Mediterranean.
In March 2014, the FMC concluded extensive review of the Trans-Pacific and Trans-Atlantic effects of the P3 Agreement and determined that the agreement was not likely at that time, by a reduction in competition, to produce an unreasonable increase in transportation cost or an unreasonable reduction in transportation service under section 6(g) of the Shipping Act.
P3 Agreement parties would have been subject to specifically tailored monitoring reports to ensure compliance with the Shipping Act once the agreement became operational. The Commission's decision remains in effect absent a withdrawal of the agreement by the parties.
About the Author
Patrick Burnson, Executive Editor Patrick Burnson is executive editor for Logistics Management and Supply Chain Management Review magazines and web sites. Patrick is a widely-published writer and editor who has spent most of his career covering international trade, global logistics, and supply chain management. He lives and works in San Francisco, providing readers with a Pacific Rim perspective on industry trends and forecasts. You can reach him directly at [email protected]Subscribe to Logistics Management Magazine!
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5 Supply Chain Trends Happening Now 2017 Warehouse/DC Equipment Survey: Investment up as service pressures rise View More From this Issue


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Crolla v Linares tips
Our Simon Crawford believes Anthony Crolla will fall short for a second time when he faces Jorge Linares this weekend.
Crolla relishing home comforts
Anthony Crolla is confident the support of Manchester can carry him to victory over Jorge Linares on Saturday night.
World title boost for Smith
Liam Smith has been handed an instant opportunity to reclaim his WBO world super-welterweight title.
Eubank Jr calls out Bellew
Chris Eubank Jr has called out Tony Bellew for a fight at catchweight following an escalating war of words on Twitter.
Fury granted New Zealand visa
Peter Fury will be allowed into New Zealand to help his son Hughie prepare for a world title challenge.
Clarke: We had to fight
Frazer Clarke felt he had to fight for the British Lionhearts a day after watching the London terror attack unfold.
Boxing schedule & fight dates
Heavyweight champion Anthony Joshua is set to face Wladimir Klitschko in April - see our big fight diary!
Live sport on TV this week
Our guide to the live sport on TV from Saturday March 25 to Sunday April 2, accompanied by the latest odds.
Crolla aims for career best
Anthony Crolla has no doubt beating Jorge Linares in their rematch on Saturday would be the highlight of his career.

subset: commoncrawl


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From | TOKI...@aol.com |
Subject | Re: Nasty chunking bug (in MSIE?) when using ap_rwrite()/ap_rflush() |
Date | Mon, 16 Jul 2001 18:58:22 GMT |
In a message dated 01-07-16 18:16:37 EDT, Ian Holsman wrote... > On 25 Jun 2001 12:13:51 -0400, Bill Stoddard wrote: > > I have a module that calls ap_rwrite() followed by ap_rflush(). Content > length is not > > provided so Apache 2.0 chunks the response. > > > > Here is what happens... > > I call ap_rwrite() to write a x75 len byte stream. All the correct > headers are built, and > > the content is buffered by the OLD_WRITE filter. Then I call ap_rflush() > which causes the > > headers to be sent on the wire along with the first chunk (x75 length). My > handler is done > > at this point and returns control to Apache. The next thing Apache sends > on the wire is > > the 0 byte chunk header to indicate that the response is done. > > > > The problem: IE chokes when it receives just the 0 byte chunk header in a > packet. > > > > Thoughts? > > > > Bill > > > hi Bill, > I was wondering if you got anywhere with this > I'm seeing this with mod_proxy at the moment. > > my inital thought was to put some logic in the chunking filter > just not to send the 0 byte chunk out.. can you see anything barfing > on this? > > what do you think? > > -- > Ian Holsman firstname.lastname@example.com > Performance Measurement & Analysis > CNET Networks - (415) 364-8608 You have to send the 0 byte chunk... but that's not all there is to it. The 'Entity headers' and then the final 'blank line' (CR/LF) is what actually ENDS the chunked transfer. You have to 'hang tough' on the client side on a 'Keep-Alive' and only use the final blank CR/LF as an EOD signal. You can't bail when the '0' chunk length shows up or you could end up leaving the Entity headers + final blank CR/LF in the input buffer and think these chars are the start of the next response when you get back to reading your input buffers on the NIC on next Keep-Alive. Whoever/whatever is 'adding' the '0' byte must also be adding A) The CR/LF that follows the 0 byte hex string B) All of the Entity Headers + CR/LF ending each one C) The final 'blank' CR/LF that ends the chunking. If any of the above is missing maybe that is why MSIE is 'choking'. I would find it hard to belive that a modern browser would screw up a chunking byte length appearing all by itself at the top of a new packet ( Even though that's highly unusual... usually it's right at the end of the data in the same final data packet ). Kevin Kiley | |
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A 72-year-old male motorcyclist is dead following a crash with a vehicle on the Brynderwyn Hills.
The motorcyclist was traveling north on the south-side of the Brynderwyn Hills and collided with a vehicle traveling south at around 7:30am.
Police, fire service and ambulance were at the scene earlier this morning.
The road was reduced to one lane while police examined the scene, however it is now cleared and traffic is free-flowing.
Serious crash on Brynderwyn Hills
8:10 AM Thursday Feb 20, 2014


text: locators definition March 20, 2017 AZ Dictionary Link to this page noun: Plural as a type of locator. Related Sources Sentence for "locators" GRACE: And you know -- out… View More Phrases for "locators" electronic locators View More How would you define locators? All the definitions on AZdictionary were written by people just like you. Now's your chance to add your own! Your Full Name Your definition Post Definition


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Posted on March 13, 2017
Bee Sting Cakes //
It's really feeling like springtime here in Glasgow. The sun's been shining, the crocuses and daffodils are starting to bloom, I love it! Spring is probably the best season, in my opinion. It's my birthday in April, daffodils are my favourite flowers, and there's something so exciting about seeing the seasons change from winter to springtime.
Spring baking needs to be light, sweet and fun. So when Inghams got in touch about their latest project, Ingham's Foodie Finds, celebrating the culinary delights of some of the most popular European destinations they visit, I had the perfect thing in mind already! It's an adapted version of the German sweet treat, Bienenstich, aka Bee Sting Cake. It's a honey sweet sponge cake, topped with a buttery, honey-almond streusel. The original version is served full of custard, so I'd recommend serving it with that, or warm with a lovely scoop of creme fraiche. Read More
Posted on February 12, 2017
Persian Love Cake //
I've wanted to try a Persian love cake recipe for YEARS. But I've never been organised enough to bake it in time for Valentines. I'm almost not this time but hey, even if no-one makes it, at least I've finally done it! The legend goes that a beautiful girl wanted to woo the Prince of Persia, so she baked him a cake, loaded with the spices and scents of Persia – cardamom, rosewater and pistachio. I'd like to think she succeeded, who could resist the romantic charms of someone baking them a cake? So sweet.
Posted on January 24, 2017
Cranachan Cake //
January 25th marks Burns Night here in Scotland, which celebrates the birth of Robert Burns, the famous Scottish poet who wrote Auld Lang Syne. For a larger summary of his published works, check Wikipedia! Haha. In Scotland, the day is celebrated with haggis, neeps & tatties, plenty of whisky, some bagpipes and the traditional Scottish dessert, cranachan. Read More
Posted on January 21, 2017
Chocolate & Banana Bundt with Whisky Caramel //
I know, I know…. whisky caramel. I really do spoil you. This is a recent discovery of mine and I've quickly become obsessed with it, on everything and anything. It's inspired my next bake (hopefully to be blogged later this week, in time for Burns Night!) and I've baked several batches of brownies laden with it, as well as the gingerbread recipe it originally accompanied from April Carter's book, Decorated. It's honestly life changing. Read More
Posted on January 8, 2017
Hazelnut, Poppyseed & White Chocolate Cake //
Well, a very happy new year to all of you! I love new years, it's a great time for reflection, and thinking about what you'd like to achieve in the coming 12 months. I've got several goals for 2017, including writing more letters, travelling more, and expanding my business! It's going to be a good one, I can feel it! Read More
Posted on December 21, 2016
Sweet Potato Pie //
I don't know about you but it's easy to get overwhelmed with everything that's going on around Christmas time. I'd planned a bunch of festive bakes, but with working full time, seeing friends and spending time with my boyfriend, making and planning Christmas hampers and you know, sleeping, this month has flown by without me doing any of them! It's fun to have plans but, it's easy to forget important things. Like that dessert you promised! Nightmare. That's where this super easy bake comes in. Read More
Updated on December 14, 2016
Sweet Mini Nut Loaves //
Like it or not, Christmas is just around the corner. I'm trying to put together some delicious bakes to give as gifts this year, as well as trying to assemble hampers to sell. It's been fun taste testing all the lovely things, and my Pinterest is overflowing with delicious ideas. There's just not enough time in the day!
When asked by Wren Kitchens to create a recipe, themed around a 'Christmas with a twist' idea, my first thought was a sweet, cakey version of our family classic, nut roast. Growing up vegetarian, nut roast was a staple of every Christmas. My Mum's recipe changes every year, and she generally just throws in whatever she has handy, but it's always nutty, oaty, and delicious, and a real festive favourite for me. It's got hazelnuts in it, but you could substitute them for any nuts you like. Same with the cranberries and fruit. You can bake it in a large loaf tin, or in little baby tins, which would make a lovely homemade gift! Check out all the recipes here! Read More
Updated on October 17, 2016
Pumpkin Spice Latte Cake //
Here's a terrible secret: I tried a pumpkin spice latte, and I wasn't a fan. It was just far too sweet, sickly almost, and I found it quite cloying. That was last year. Now never call me a quitter, because I decided to try one again, but this time with half the syrup, and soy milk (my new best friend, as the proud owner of a burgeoning lactose intolerance). It was SO GOOD, and I've had at least one a day (ish) since. Yum! Cinnamon spicey with just the right amount of sugar. I'm a fan. As a baker I naturally turned to see if there was a cake version I could whip up with my stack of canned pumpkin, but to no avail. So I rolled up my sleeves, threw on my apron, and made this guy for you: my pumpkin spice latte cake. Read More
Updated on October 5, 2016
Overnight Cinnamon Buns //
As I write this, it's the eve of my favourite national holiday: cinnamon bun day. I'm obsessed with cinnamon buns. I love them! I'm constantly on a quest to find the perfect recipe. This one is pretty darn close. It's yeasted, so you need to allow some time to prove. But, once rolled, you pop them in the fridge overnight, bring them out in the morning, and once they've come back to room temperature they're good to go! They're sticky, squishy, and delicious. Read More
Updated on September 18, 2016
Pumpkin Chocolate Chip Cupcakes with Pecan Butter Frosting //
So summer has been over since roughly May, and I am fully ready to embrace Autumn. It is, in my opinion, the best season. Cold but sunny days, wearing a scarf, crunchy leaves, hot chocolate, cinnamon on everything… these really ARE a few of my favourite things. Pumpkin bakes are ubiquitous on Pinterest and Tumblr at this time of years, and having recently embraced pumpkin as a yummy autumnal foodstuff, I'm happy to share these with you, my pumpkin & chocolate chip cupcakes, with pecan butter frosting.


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List of States' Rights Bills
Sign Up to Support States' Rights
Discuss States' Rights Issues in our Forum
Return to list of Bills
State Sovereignty & States' Rights Patriot Tool
Text of Bill
Missouri Bill #HCR18
View details of Bill
Go to Bill Online
House Concurrent Resolution No. 18
Whereas, the current health care proposal being debated in the United States Congress will raise federal taxes and force new taxes on Missourians, which are detrimental to Missouri's economy; and
Whereas, Missouri families and employers may be facing even more mandates that drive up costs if the United States Congress passes its latest health care bill, H.R. 3200; and
Whereas, the federal government's attempt to reform health care has overwhelmingly centered around increasing eligibility to health care, but not addressing important issues such as increasing access, provider rates or quality of care; and
Whereas, there has been a complete lack of transparency during the final negotiations to craft this legislation and special deals have already emerged that are going to put Missouri at a disadvantage; and
Whereas, the unfunded mandates and special deals will place greater pressure on Missouri taxpayers and put funding for education, mental health services, public safety, and all other essential state services at risk:
Now, therefore, be it resolved that the members of the House of Representatives of the Ninety-fifth General Assembly, Second Regular Session, the Senate concurring therein, hereby urge our Missouri Congressional delegation to vote against H.R. 3200 and to further request that our elected statewide officials express their respective positions on the passage of H.R. 3200 and send a unified message to our Missouri Congressional delegation; and
Be it further resolved that the Missouri General Assembly urge our elected statewide officials to review the constitutionality of H.R. 3200, which includes several special deals for other states, including the "Nebraska kickback"; and
Be it further resolved that the Chief Clerk of the Missouri House of Representatives be instructed to prepare properly inscribed copies of this resolution for Governor Jay Nixon, President Barack Obama, the President of the United States Senate, the Speaker of the United States House of Representatives, and each member of the Missouri Congressional delegation.
Return to list of Bills
The information contained in this web site is not official information and is not guaranteed to be accurate. It has been compiled from official records available to the public. To correct inaccuracies in or omissions from the information on this site, please contact us via


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Give us a call to get our secret deals 1-800-468-3578
Property Location
When you stay at Extended Stay America - Dallas - Bedford in Bedford, you'll be in the suburbs and convenient to Westdale Hills Golf Course and Artisan Center Theater. This hotel is within close proximity of WhirlyBall & LaserWhirld Mid-Cities and Texas Star Golf Course.
Make yourself at home in one of the 84 air-conditioned rooms featuring kitchens with full-sized refrigerators/freezers and stovetops. 32-inch flat-screen televisions with cable programming provide entertainment, while complimentary wireless Internet access keeps you connected. Conveniences include desks and microwaves, and housekeeping is provided weekly.
Enjoy recreational amenities such as a fitness center and a seasonal outdoor pool.
A complimentary continental breakfast is served daily.
Business, Other Amenities
Featured amenities include laundry facilities, a safe deposit box at the front desk, and an elevator (lift). Planning an event in Bedford? This hotel features 0 square feet (0 square meters) of event facilities. Free self parking is available onsite.


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Additions: If you are a natural lifestyle company (natural food restaurant, health food store, holistic retreat, etc.) that would like to be added to our site, CLICK HERE to see your advertising options. |
Since 2000, VegetarianUSA.com has offered free online city & state guides featuring vegetarian vacations, natural food restaurants, natural food co-ops, new age bookstores, natural lifestyle events & retreats, and yoga studios. Our popular guides also include our favorite vegan resources & products, environmental groups, sustainable communities, raw food teaching centers and lots more! Choose any guide from our home page or scroll-down menu at the top right of each page. Have fun and enjoy your healthy adventures! |


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Check out everything that's happening at CUNY Law
Right Wrongs Your gifts lead to social change and justice.
Alumni Community We're committed to life-long relationships with our graduates.
CUNY Law ImpactThe story of CUNY Law is the stories of our alumni and the impact they have on the world.
At least 30 CUNY Law grads have served as judges in NY and beyond.
2017| 2016| 2015| 2014| 2013| 2012| 2011| 2010| 2009| 2008| 2007| 2006
The Queens Courier's Spotlight on Justice series recently focused on alum Judge Margaret Parisi-McGowan ('87) and her work on the Queens County Family Court. Judge Parisi-McGowan first served as a housing court judge in the Queens County Civil Court before being appointed to the Family Court in 2006 by Mayor Michael Bloomberg. "You save a lot of kids' lives and turn families around," she said. "Sometimes it's sad and emotionally draining, but it's rewarding because you turn around a lot of families."
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This happened to me with the circular saw. I bought it brand new from the hardware store (got the one they recommended for the job) and after 3 mats...
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Chinti and Parker's playful intarsia designs have earned the label a cult following. Spun in Italy from cozy cashmere, this color-block 'Lovecats' sweater has pretty pink and papaya panels contrasted with cream and black stripes. Try yours with jeans and pumps.Shown here with: M.i.h Jeans Jeans, Loewe Clutch, Stella McCartney Pumps, Kenneth Jay Lane Earrings.
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Register | FAQ | The Twelve Commandments | Members List | Calendar | Arcade | Search | Today's Posts | Mark Forums Read |
Open Discussion topics Discuss the time of day, whatever you want to. This is the hangout area. If you have LimeWire problems, post them here too. |
Welcome To Gnutella Forums You are currently viewing our boards as a guest which gives you limited access to view most discussions and access our other features. By joining our free community you will have access to post topics, communicate privately with other members (PM), respond to polls, upload content, fun aspects such as the image caption contest and play in the arcade, and access many other special features after your registration and email confirmation. Registration is fast, simple and absolutely free so please, join our community today! (click here) If you have any problems with the Gnutella Forum registration process or your Gnutella Forum account login, please contact us (this is not for program use questions.) Your email address must be legitimate and verified before becoming a full member of the forums. Please be sure to disable any spam filters you may have for our website, so that email messages can reach you. 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Hulp in het Nederlands Forum Rules Support Forums Before you post to one of the specific Client Help and Support Conferences in Gnutella Client Forums please look through other threads and Stickies that may answer your questions. Most problems are not new. The Search function is most useful. Also the red Stickies have answers to the most commonly asked questions. (over 90 percent). If your problem is not resolved by a search of the forums, please take the next step and post in the appropriate forum. There are many members who will be glad to help. If you are new to the world of file sharing please do not be shy! Everyone was new when they first started. When posting, please include details for: Your Operating System ....... Your version of your Gnutella Client (* this is important for helping solve problems) ....... Your Internet connection (56K, Cable, DSL) ....... The exact error message, if one pops up Any other relevant information that you think may help ....... Try to make your post descriptive, specific, and clear so members can quickly and efficiently help you. To aid helpers in solving download/upload problems, LimeWire and Frostwire users must specify whether they are downloading a torrent file or a file from the Gnutella network. Members need to supply these details >>> System details - help us to help you (click on blue link) Moderators There are senior members on the forums who serve as Moderators. These volunteers keep the board organized and moving. Moderators are authorized to: (in order of increasing severity) Move posts to the correct forums. Many times, members post in the wrong forum. These off-topic posts may impede the normal operation of the forum. Edit posts. Moderators will edit posts that are offensive or break any of the House Rules. Delete posts. Posts that cannot be edited to comply with the House Rules will be deleted. Restrict members. This is one of the last punishments before a member is banned. 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Customer Support Phone number? I am having problems connecting to the Gnutella server. I changed my firewall settings, but still i can not connect. As a result i can not serch for or download music. I followed the step by step instructions on the web site for Windows users, but still no result. Is their anyone out there who knows what my prblem may be, or a help desk phone number for Lime Wire i can call. Thank You, Mike |
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LW support does not have a telephone no. If you're a pro user you can email them. Do this simple test for us. Using your browser go here: http://www3.limewire.com:6346/ The page should say 'Your test worked!'. What happens when you go there? Can you give us a total desciption of your set up: 1. OS version? (eg: Windows 98) 2. What firewalls you have? 3. How much ram? 4. Hard Disk space available? 5. Connection type? (eg: dialup, broadband, cable, etc.) 6. Modem & router brand name & model numbers? 7. Where are you trying to connect from (home, school, work, etc.)? 8. What version of Limewire (LW) & Java do you have? (Go to LW's menu Help>About LW...) Will show both LW & Java version. 9. Who is your isp provider? 10. Is this a your 1st try at LW or is this a new problem with an experienced user. |
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There is no Gnutella server. There is the gnutella network which is a protocol. You connect to other users like yourself. To help connect you connect through ultrapeers. Basic LW users connect to 3 UP's, Pro users 5. Check options here first: http://www.gnutellaforums.com/connec...t-connect.html |
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Help Sorry to bother everyone but iam new and iam having trouble starting my limewire I already downloadded java and the pro limewire but when I try to start the limewire it gives me a fatal error screen. It says limewire has encountered a fatal internal error and will now exit. it says it might me caused by a corrupted installation. I tried downloadding it again but it wont take my email. Iam new with computer software installation so I dont now much. Ive been trying to find a number to get help since they say they have someone to help me but nothing. So if there is anyone out there that can give me a number or help i would appriciate it. thank u. |
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If you bought Pro, then go to the customer support section: Lime Wire » LimeWire PRO Support Center Otherwise, or in the meantime, please supply these details: System details - help us to help you (click on blue link) |
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__________________ So Long and Thanks for All the Files _____________________________________________ Beware of the big 3 insurance companies in Texas! Read your policies carefully (maybe you'll need a lawyer) Allstate, Farmers & State Farm are overextended and their 'coverage' is worthless...a true waste of your money Read This |
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Insanely Great Mac just posted an article about who's upping their pc prices. NEC, Sony and Trigem Computer say they are raising prices for the first time in at least five years in order to keep pace with the higher cost of chips and other parts, according to a Bloomberg report. http://www.insanelygreatmac.com/news.php?id=220 Apple, always the trend setter.....
those two companies will have to follow suit most likely...so what else is new in this biz? i could see dell keeping the prices the same due to their leverage and big money...frequent repairs (i was a dell next day tech in first IT job) does not scare the pc crowd who is so used to high maintenance machines and dell's big gains in education further reinofrces that dell will one day become the "microsoft' of the hardware world i had dell clients who were seeing an onsite tech for their third time in one year! in the meantime, i will enjoy my mac and not have to worry about frequent "repairs"
I don't think I would want to be the trendsetter when it comes to raising prices. The first to do it will always receive the most grief, while those that do it after can slip by without comment.
And where are the whiners who were crying about how Steve Jobs was killing Apple by artificially raising prices and... blah, blah, blah...?
Lets all just be happy that the iMac is now shipping in "large" (well supposivly) quantities. The price hike wasn't Steve's best move in my opinion, but we can all learn to live with it. Besides iMacs are full of joy, smile at you with their optical drives and are quiet and 100% quality (unlike Dell).
Apparently the neither Apple shareholders nor the brokerages (u can see this in their (UBS WB) press realease the day after SJ raised the price) are happy about SJ raising the price on the iMac.
I think the most worrying part about that article is the claim that "the market is almost saturated". With the huge advance in computing power that we've seen in the past few years, i doubt many consumers will be upgrading for a long time. That could drive prices even higher. Not good
some months back, taiwan had another major earthquake and ram prices went up again...predictably but now they have just gone back down and my neighbor bought 512 MB ram for two hundred when it was up fifty percent higher right after the earthquake...he just waited a couple of months and down the price came last time i checked the lcd imac is still one hundred higher and i wonder if that has anything at all to do with the taiwan earthquake individually speaking, the lcd imac is the best deal (dollar for dollar) that apple has to offer if i had a school and had a lot of school children poking at my delicate lcd screen, i would opt for the more ruggged and cheaper emac but otherwise, the lcd imac is such a great deal...i hope apple brings the price down again...we wouldn't want any first-timers going out and buying a dell or gateway due to the price in the long run, it would be great to eventually see the imac at $999 for the base model
A thousand dollar iMac would be stripped down, small HD, and maybe a CDRW, I don't think we will see one for a long time. There is no point stripping it down.
Indeed, I think it would be a great thing for the iMac to come in at a clean $999/£999, people are, on the whole arrogant when it comes to computers and I think that walking into a store where PCs and Macs were side by side, then to see the fantastic LCD iMac with that price tag hanging beneath of under $1000/£1000 may help push people towards the Mac, along with the stunning design of course.
a couple of years ago, a 15" flat panel lcd was a thousand with technology going the way it is, we will see a sub-thousand dollar imac without it being stripped down...but maybe not this year though who thought there would be any imac at 799 usd?


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Northeastern researcher to identify new treatments for Lyme with help from $1.5M grant
Northeastern University Distinguished Professor Kim Lewis has received a $1.5 million grant from the Steven & Alexandra Cohen Foundation to develop better treatments for Lyme disease.
Assistant Teaching Professor awarded Excellence in Teaching Award
The Office of the Dean is pleased to announce Melissa (Missy) McElligott the recipient of the 2015-2016 College of Science Excellence in Teaching Award.
NU Talk 2016 brings together student scientists
Scientists and researchers. Educators and future doctors. These were the people behind NU Talk 2016.
Longtime Northeastern chemist receives prestigious AAPS award
Alexandros Makriyannis, George D. Behrakis Endowed Chair at Northeastern and Founder and Director of the Center for Drug Discovery, has received the American Association of Pharmaceutical Scientists Distinguished Pharmaceutical Scientist Award for 2015. This award is part of a long line of accomplishments for Makriyannis, who has published over 500 papers and has over 50 patents in the field of medicinal chemistry.
Slava Epstein: From immigrant painter to world-renowned biologist
When Slava Epstein first arrived in America, he had little more than his family, a smuggled cat, and an "enormous amount of data" from his research in Russia. In 2015, he was part of one of the world's biggest scientific stories.
3Qs: Four new elements added to periodic table
The seventh row of the periodic table is now complete after Monday's announcement of four new elements. Chemistry professor Michael Pollastri explains why this is an important milestone for science.
Biologist, inventor, problem solver
A deep read about Professor Slava Epstein's research, discoveries, and painting skills.
Lewis, Epstein named Global Thinkers of 2015
Each year for the past seven years, Foreign Policy selected the leading Global Thinkers whose contributions and work have changed lives and are shaping the world.
COS professors get NSF grant to study production of cancer drugs
Two professors – one from the biology department and the other from the chemistry and chemical biology department – have been awarded more than a half-million dollars to investigate the production of cancer drugs in Catharanthus roseus.
Northeastern research team uncovers explanation for biofilm formation
Kevin Gozzi started working in assistant professor Win Chai's microbiology lab during his first month at Northeastern. Now, the fourth-year biology student is the co-first author of the lab's most recent publication.


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One last post before the 2009 dawn sets in.
I want to wish you the best in 2009... Let's make something big happen together!
And speaking of big... Wired named the conceptships blog write up #5 on their 2008 top ten list of gallery articles. WHOA!!!! Congrats to all of the artists featured on the mag site & on this blog and a huge thanks to WIRED magazine. It's an honor to be represented by the biggest computer science magazine in the world. HAPPY NEW YEAR!!!!!!!!!
Keywords: last post for the 2008 year on conceptships.blogspot.com wired magazine article number five # 5 on top ten of 2008 gallery articles conde nast
Wednesday, December 31, 2008
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Our new unique monocular telescope features portability with a pocket size body designed, that you can easily put into the pocket or take on your trip at anytime you need.
Magnification | 6x |
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Anti Discrimination Commission Queensland Homepage
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Information and resources for Queensland students and teachers about rights and responsibilities under the Anti-Discrimination Act 1991.
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The Anti-Discrimination Commission has statutory responsibilities under Queensland anti-discrimination law.


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My name is Henry á Fríðriksmørk. I enjoy mixtapes a bit more than I like listening to the radio. More you and me and not so much them and they. Visit my blog where I put up art and music: henrypenry.tumblr.com and also my vimeo where I upload some of my homevideos: vimeo.com/henrypenry
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Old Pianos
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These songs were written in smoky rooms, on pianos with lots of beer stains on them


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Homemade Sambal Oelek
Recipe by dale!
A staple in Malaysian and Thai cooking. Oelek means grinding so sambal oelek means ground chilli sambal! This can also be frozen.
Top Review by Cookingetcetera
Firstly I'd like to straighten things out, sambal oelek is from Indonesia - but the spelling is old Dutch, where the first 'sambal oelek' brand was introduced. The word is javanese origin, meaning ground by stone mortar. There's no 'oelek' word in Malaysian....
Secondly, right about the sugar amount used in this recipe. Way too much. Besides, the real sambal oelek used brown palm/coconut sugar.
See Discussion:
8 ReviewsIngredients Nutrition
- 1 lb red chile
- 5 1⁄2 ounces garlic, peeled and chopped
- 5 1⁄2 ounces tender young ginger, peeled and chopped
- 2 stalks lemongrass, thinly sliced (white part only)
- 6 fluid ounces vinegar
- 8 ounces sugar
- salt, to taste
- 1 tablespoon lime zest, chopped
- Blend the chillies, garlic, ginger and lemon grass in a food processor or mortar and pestle.
- While processing gradually add the vinegar.
- Place the pureed mixture into a saucepan and bring to a boil.
- Reduce the heat and simmer for 3 minutes.
- Add the sugar and stir until dissolved.
- Add the salt and lime zest.
- Remove from the heat, cool and bottle in sterilised jars.


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Defense of the Ancients, commonly known as DotA, is a modification released for the popular Real-Time Strategy game Warcraft 3. As a modification of the original video game, the controls used for DotA are the same as the controls in Warcraft 3. When playing the game, it can be convenient to change the camera view in order to gain sight if your view is being obstructed by an object. There are several simple controls that can be accessed to zoom, pan and rotate your camera view while playing.
- Skill level:
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Start a new game of Defense of the Ancients. Join a new game online or create your own private match.
- 2
Zoom in and out on the screen by using the scrolling wheel on the mouse. Scrolling up will zoom in, and scrolling down will zoom your camera out. Alternatively, you can use the "Page Up" and "Page Down" keys for the same effect.
- 3
Pan the camera view by pointing your mouse toward the edge of your screen. The camera view will pan to the side of the screen toward which your mouse is pointing.
- 4
Rotate the camera view by pressing the "Insert" and "Delete" keys. Pressing "Insert" will rotate your view by 90 degrees counterclockwise. Pressing "Delete" will rotate your view clockwise.


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Buy DiamondDiamond is one of the rare and expensive stone that is really desirable and valuable. With its glittering shine and lavishness in style, diamonds are always a great piece to treasure it for throughout the life. Normally, the value and worth of diamond is calculated on the basis of its clarity, cut, color and carat or weight. Once you get aware of these 4 c�s, it becomes easier to choose a right and perfect diamond that reflects its charm and beauty brilliantly. Clarity, cut, color and carat complete the 4�c of diamond that ensures its actual worth of a diamond. Here, clarity refers to the clearness of the diamond i.e. the transparency as well as the size and varieties of the diamond. Cut refers to symmetry, finish, polish and depth of the stone which determines its brilliance. The rareness of colors in diamond also affect the price of a diamond as blue, pink, yellow diamonds are really limited and hard to locate thus increasing the price of the diamond. Carat or weight of the diamond is also a major influencing factor in fixing a price of a diamond as price increases with an increase in weight. Now, when you are sure about these 4c�s, locating a good and suitable diamond for your choice becomes easier. You can go to different sellers and compare the prices of the same piece. Just match the stone with your understanding and needs. For making an effective purchase, you can also go for loose stones as they are economical and vivid in their varieties. From there, you can pick your favorite stone with its color and get it fixed in your preferred design and metal. You can also order a diamond of your choice if it is not available in their store, they will deliver your order in their next lot. Nowadays, online jewelry purchases are also becoming a hot market. It is a great collection of different varieties of diamonds available in affordable price and great designs. So, try to learn about 4 c�s correctly and accurately as they will ensure your search for a good diamond. Check the guarantee card and other certificates very well to make sure their clarity, cut, carat and color specifications. See, if it is a suitable piece for your beloved or the person you are intended to gift as it is that brilliant and lavish piece of jewel that a person cherish for her entire life.
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David Crumpton's Blog
David Crumpton's Blog and Personal Notes
31 May 2015
TV, Ubuntu, and AMD's TV Wonder 600 USB Installation
The ATI TV Wonder 600 USB is not supported on Windows 7 or later but is still supported on GNU/Linux. The best thing to know is that it's really quick and easy to setup and install on Ubuntu. All you need to do is execute three steps and you can watch TV in less than 5 minutes. The instructions on the
Linux TV website
are all you need and always up to date. To be brief, open a terminal window and perform the following commands:
cd /lib/firmware
sudo wget
sudo apt-get install me-tv
And that's all there really to is to it. Just start
Me Tv
and scan for stations.
The short video below shows you the steps.
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Contemporary Acrylic Podium (#C04)
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Cleopatra Milk & Honey Bath Bomb
This is by far one of my most popular bath bombs! A best seller year round! Made with beautiful, natural milk powders and spa salts.
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- 5 Ounce Bath Bomb
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Nikita Von James gets fucked her hard by her boyfriend`s sonDescription
Nikita Von James is meeting her boyfriend`s son for the first time. They`ve seen one another around the gym, but he was too shy to up and introduce himself. Now Nikita is going out with his dad and he`s pretty sure she`s only after his dad`s money. But Nikita is there to prove she likes the family not because of their money but because of the family jewels they`re packin`.Cast
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I am a professional painter and I regularly participate in many different art shows. I got my BFA at the School of Visual Arts under Illustration and my master's degree in art education also at the School of Visual Arts.
I am very passionate and serious about student learning. I want to inspire students to love art and let them find
Approved subjects are in bold.
In most cases, tutors gain approval in a subject by passing a proficiency exam. For some subject areas, like music and art, tutors submit written requests to demonstrate their proficiency to potential students. If a tutor is interested but not yet approved in a subject, the subject will appear in non-bold font. Tutors need to be approved in a subject prior to beginning lessons.
Drawing can be fun. I will teach students various tools, media and techniques that can be used for drawing. They will draw from observation, images and also from head. Free drawing, gesture drawing, landscape drawing and many other types of drawing will be taught. Students will find drawing more intriguing than ever. I completed my BFA in Illustration at School of Visual Arts.
I am a professional painter. I completed my BFA in Illustration at the School of Visual Arts and had my first solo exhibition at one of the Chelsea's fine art galleries. I know various painting techniques. I can teach old classic painting style, modern abstract painting style or whichever you like to learn. From my painting lesson, you will become a better artist with your own artistic voice.
Art College Portfolio/Drawing/Painting/ Korean for anyone


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Here at Tuttons we are passionate about creating an outstanding experience for our guests on every level and firmly believe that the people who run our restaurants are a key ingredient in achieving this.
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Simone Bignall's primary research interests fall within the field of political philosophy, often informed by her active participation in various communities of practice. Her academic work traverses Continental philosophy and critical political theory, colonial and postcolonial politics and culture, theories of embodiment and agency, feminism, psychoanalysis, and ethics.
While the projects Bignall has developed have been diverse in focus and range, her approach to various problems has been guided by my particular interest in the philosophical lineage from Spinoza to Deleuze, as well as the political philosophies of Foucault and Agamben. Her overriding aim has been to develop aspects and applications of this thought in order to define alternative ways of thinking about agency and the potential transformation of entrenched and habitual social practices. Through this work, she seeks to describe types of practice that encourage diverse peoples to live respectfully, responsibly and joyfully in community with one another.
Her recent publications include:
- 'Desire, Apathy and Activism', Deleuze Studies, Special Issue 2010, pp. 6-21.This paper was published from the proceedings of the 'Deleuze and Activism' conference held in Cardiff, Wales, December 12-13 2009, where I was an invited speaker. The paper develops thinking about causation, complex affectivity and politics. It has already attracted international citation (Aitken and An 2011).
- 'Postcolonial Agency and Poststructuralist Thought: Deleuze and Foucault on Desire and Power', Angelaki, General Issue, 2008, pp. 127-49.This article, published in an ERA ranked A* journal, has been cited in international scholarship (eg. Noyes, 2010; O'Byrne and Holmes 2011; Henderson 2010; Flores-Bradshaw 2009). My peers have offered spontaneous correspondence, acclaiming the new directions for research opened up by the argument presented here.'A Superior Empiricism: The Subject and Experimentation', Pli (Warwick Journal of Philosophy), 18, 2007: pp. 201-217.This essay offers a novel interpretation of Deleuze's philosophy of the subject, arguing that a concept of complexly embodied agency is evidenced in Deleuze's work.
She earned her PhD in Philosophy from University of Sydney and her Bachelor of Arts, Honours (First Class in Politics) from University of Adelaide.
Credits to Open University
Published: 19 March 2014
Last update: 23 April 2015


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It seems like every big city is facing a major housing crisis. But things are looking up in London: not only is the city planning an astounding 230 new towers that will fundamentally change the skyline, but an impressive 80 per cent of those towers will be residential.
A survey by GL Hearn for New London Architecture yielded some amazing data: 236 buildings over 20 stories are planned for the city, with two-thirds of those structures already approved or under construction. 22 of those buildings will be 50 stories or more—so, for some perspective, consider this: the Shard towers over the city at 87 stories, but all of London's other tallest buildings are 50 stories or less. That's gonna be a dramatic shift for the skyline.
But here's the best news: 189 of the high-rises will be residential, which will hopefully help ease housing costs. It doesn't say whether or not the housing is affordable, but any housing is good housing in the notoriously expensive city. Related: A story from Guardian Cities on how rising property values are driving out creatives in "Silicon Roundabout."
This sounded like an unusually high number of towers for a single city to be planning, so I reached out to the Council on Tall Buildings and Urban Habitat, which releases an annual tall building report. Although editor Daniel Safarik hasn't seen the full report yet, he did say that it's fairly rare for such studies to be issued—and that the numbers sound a little high. "They're looking at everything 20 stories and higher, which would tend to fall a bit below our radar, which we don't advertise as being accurate below 100 metres—or about 28-30 stories, depending on floor-to-floor heights," he says. "We list only 73 visionary, proposed, under-construction and 'topped-out' tall buildings in London at this time. I would be quite interested to see what their methodology was."
What Safarik also did for me was use CTBUH's methodology to compare London's building boom with that of New York City, where CTBUH shows 181 proposed, under-construction, topped-out, and visionary skyscrapers for the city. Curious about other cities? You can play around with CTBUH's Tall Building Database, which lets you slice and dice data on every skyscraper ever built or proposed on the planet.
An exhibition featuring the results of the London study will open on April 2. [London's Growing Up!]
Image Credit: City of London one of the leading centers of global finance from Shutterstock.com


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Photo by Chip SomodevillaGetty Images Congresswoman Ann Wagner says that she plans on continuing to push to repeal and replace Obamacare. She wants to do what's best for her constituents, and Obamacare is in a death spiral.
Photo by Olivier Douliery-Pool/Getty Images Doug Giles joins Jamie to discuss reports that Malia Obama (18) was not only spotted in a "21 and over" club but that she harassed Gateway Pundit reporter, Lucian Wintrich .
Photo by Chip Somodevilla/Getty Images Secretary of Health and Human Services, Tom Price, and fellow republicans are now tasked with working within the confines of Obamacare. Dr. Tobler hopes enough can be 'undone' to provide relief for families and physicians alike.
Photo by Justin Sullivan/Getty Images Judge Napolitano joins Jamie this morning to discuss the aftermath of Judge Neil Gorsuch's confirmation hearings. What is the nuclear rule? It's virtual assurance that Judge Gorsuch will become Justice Gorsuch. The Judge explains this...
Photo by Joe Raedle/Getty Images Our friend, Henry Davis, gave us a heads up about Mayoral Candidate Andrew Jones's appearance tonight, Tuesday, March 28th at the Omega Center from 6-8PM. The event is open to the public and will be a good chance to meet the candidate and hear...
Photo by Mark Wilson/Getty Images Another stellar performance from Jamie this morning. It's as if Kasich is in the room. We still don't care what's going on with Gov. Kasich but this is a FUNNY impression! Plus, our buddy Henry Davis makes an appearance. Jamie's HILARIOUS Scott...
Photo by Rick Kern/Getty Images for United Airlines Jamie and Todd Starnes discuss the story of the young women who were not allowed to fly United Airlines because of their leg attire. Is this a real controversy? Hear what Jamie and Todd have to say:
Photo by Laura Cavanaugh/Getty Images CBS's Scott Pelley (very slowly) frets over Attorney General Jeff Session's threat to pull funding from sanctuary cities . Why does Pelley sound 90? \ Watch Jamie's hilarious Pelley impression below:


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cytotec twice, and then i take 5 cortal but little blood
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doc..im dane and i take cytotec twice at the first time that i use the cytotec i woke up in the morning with a little blood..and then after a few hours the blood stops..after 2 weeks i take again cytotec the same process 1 is oral and 1 is inserted..it was also a little blood.is the abortion complete?and then i take 5 cortal thinking that the blood continousbut there was a blood but just a little and it stops again..what should i do doc.please help me
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Genomics & Society
Update on Chadam v. Palo Alto Unified School District
About a year ago we reported on a case involving allegations of genetic discrimination by a school district in California. According to the allegations, in fall 2012 the Palo Alto Unified School District used genetic information regarding cystic fibrosis in deciding to transfer a student away from his neighborhood school to another school.
Genetic nondiscrimination laws are stronger in California than anywhere else in the United States. CalGINA (S.B. 559), which took effect five years ago, extended genetic nondiscrimination rights beyond the narrow scope of the federal statute known as GINA, the Genetic Information Nondiscrimination Act of 2008, which prohibits genetic discrimination in employment and health insurance contexts. However, this case was interesting to Genomics Law Report largely because the plaintiffs did not rely on CalGINA in their complaint against PAUSD but instead focused on protections against "perceived disability" provided under the Americans with Disabilities Act or ADA (42 U.S.C.A. §§12131 et seq.) and Section 504 of the Rehabilitation Act of 1973 (29 U.S.C.A. § 794). The school district had convinced a federal district court to dismiss the complaint, but the plaintiffs filed an appeal in January 2016.
• Previous coverage of CalGINA is available here
• Previous coverage of Chadam v. PAUSD is available here
What's happened since the appeal was filed in January 2016?
The U.S. Court of Appeals for the Ninth Circuit heard arguments on October 19, 2016, and issued a decision on November 15, 2016. The court's ruling overturned the district court's dismissal of the ADA and Section 504 claims and remanded the case to the district court for further proceedings. While the court issued an unpublished judgment, which "is not precedent except as provided by Ninth Circuit Rule 36-3," the plaintiffs' attorney, Stephen R. Jaffe, publicly announced on LinkedIn that it was "a great victory for personal privacy." The Ninth Circuit Court of Appeals is allowing the ADA and Section 504 genetic discrimination claims to move forward, all based on the student's genetic information being a "perceived disability."
The court made its decision by determining that the district court erred in two ways. The first error was the district court's finding that there was a "direct threat" defense available under the facts presented in the complaint. The school district had argued that it made its decision out of concern for the health or safety of other students at the school who do have cystic fibrosis and that it had made a reasonable judgment that the student posed a "direct threat" to those other students. According to the Ninth Circuit, the error in allowing a direct threat defense was twofold: (1) such a defense requires an individual assessment of the threat but, as per the facts in the complaint (which must be taken as true in evaluating a motion to dismiss), no such individual assessment was made; and (2) the school district's decision that the student posed a direct threat was contrary to "reasonable judgment" with "best available objective evidence." The district court's second error was finding that the plaintiff had not shown the requisite intent to establish a claim for discrimination. Establishing a claim for discrimination, the Court of Appeals noted in its decision, does not require the plaintiff to show "bad motive, will, or animosity" or even an intent to cause harm. Rather, the action or decision to exclude someone categorically (e.g., because of protected class status) is "facial discrimination" and sufficient, even if no harm or injury was intended.
The case moves forward
The Ninth Circuit's rejection of the motion to dismiss means that the case is back on track toward eventual trial. There are no apparent signs that the school district will settle the case. On December 21, 2016, the school district's attorneys filed an answer to the amended complaint and raised a litany of affirmative defenses, including:
• failure to state a claim,
• lack of jurisdiction,
• lack of intent,
• immunity,
• defendant acted in conformity with law,
• equity (e.g., unclean hands and equitable estoppel),
• res judicata,
• statute of limitations,
• lack of standing,
• waiver/release,
• remedies not supported by claims, and
• no damages attributable to the defendant.
The defendant did not provide any details about these affirmative defenses to explain how or why they might be applicable. Because some affirmative defenses can be waived if not asserted, it is reasonable to treat these defenses for the moment as mere boilerplate—that is, inserted as a matter of lawyerly self-protection.
The court has ordered mediation to resume before March 14, 2017 and has since appointed a mediator to the case.
Keep this case on your watch list
Courts have never directly acknowledged a person's genotype or carrier status as sufficient to pursue a "perceived disability" claim under the ADA or Section 504 protections against discrimination. A plaintiff's victory would clarify (at least for people who live in the Ninth Circuit—CA, WA, OR, ID, MT, NV, AZ, AK, and HI) that those who are victims of genetic discrimination in areas of society other than employment or health insurance (the areas covered by GINA) are not left unprotected by federal law and are able to seek remedies under the Americans with Disabilities Act and Section 504.
The case is an important reminder that even if the PAUSD's actions were permissible under federal law, state law (CalGINA) applicable at the time and applicable today prohibits school districts in California from using genetic information to make decisions about its students. The PAUSD's decision to continue defending this case signals one or both of two things. The first is that defense attorneys believe that they can successfully slam the door on a broad ADA precedent that would allow "perceived disability" claims against those who discriminate based on genetic information. That seems somewhat unlikely, given the willingness of the Ninth Circuit to allow the case to proceed and the strength of the facts alleged by the plaintiff's attorneys. The second is that the school district is focused solely on the money—either trying to minimize the size of any settlement or court award or trying to make sure an insurer is responsible for covering the payment of that settlement or award. Perhaps the PAUSD is showing its willingness to roll the dice if a reasonable court award is perceived as having a good chance of being substantially lower than any settlement amounts under consideration.
There has been very little public discussion of the case since initial interest when the appeal was filed last year. The plaintiff's case has now survived a motion to dismiss, but the case has yet to be decided on the merits. For genetic rights advocates, this case should remain high on the watch list in 2017 with the Ninth Circuit Court of Appeals poised to strengthen genetic nondiscrimination rights through ADA and Section 504 case law.
FDA Issues Guidance for Next Generation Sequencing
On July 8, 2016, the FDA issued draft guidance on the subject of next generation sequencing (NGS) activities: (1) "Uses of Standards in FDA Regulatory Oversight of Next Generation Sequencing (NGS)-Based In Vitro Diagnostics (IVDs) Used for Diagnosing Germline Diseases" and (2) "Use of Public Human Genetic Variant Databases to Support Clinical Validity for Next Generation Sequencing (NGS)-Based In Vitro Diagnostics." The first focuses on the FDA's proposed use of standards to help establish the safety and efficacy of NGS-based tests. The second focuses on the importance of high quality and publicly accessible databases to provide robust scientific evidence for understanding genomic variation, to inform decision-making, and to assess the clinical validity of NGS-based tests. Guidance is not a formal regulation, but rather an agency's statement about how it will interpret or apply a regulation in the future. Draft guidance is a proposed policy that means the agency is formulating a position, whereas a final guidance is a document that represents what the agency has settled on as its interpretive policy. In theory, guidance is intended to serve as additional instructions for complying with rules and not intended to serve as the rules themselves.
The premise underlying the draft guidance is the controversial and—as yet—legally untested assertion that genomic analyses of all kinds are "medical devices" that Congress has, by statute, authorized the FDA to regulate. If they are, then the FDA would have the power to bring them under its current risk-based classification scheme for medical devices or to create a new scheme for them. If they are not medical devices, then the effort to regulate them might exceed the FDA's statutory authority and conceivably amount to an unconstitutional regulatory overreach. Both draft guidance documents avoid any mention of the overarching debate, a subject covered extensively on Genomics Law Report, surrounding FDA oversight of all laboratory developed tests (LDTs) and in vitro diagnostic multivariate index assays (IVDMIAs). As others have noted, it is impossible to consider these new pieces of draft guidance outside of that context. Nonetheless, even the FDA asserts (via Twitter and elsewhere) that the two new drafts are intended to facilitate the Precision Medicine Initiative (PMI) and are distinct from the agency's expressed intention to regulate LDTs. These pieces of draft guidance also give a policy-based reason for pause, as they could be another example of governance by guidance, a highly problematic approach as highlighted recently by John Conley with regard to the HIPAA right to access lab data and results.
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Cleveland Clinic Pathologist Urges Contract Solution for Return of Genomic Data
The Cleveland Clinic's Roger Klein responds to my previous GLR post:
The Office of Civil Rights' interpretation of the requirements of 45 CFR § 164 could pose problems for clinical laboratories and the professionals who practice within them. Although the issue of providing benign variants for a single gene, at least prospectively, would be straightforward, a broad definition of the designated medical record set could result in considerable complexity when one considers large-scale sequencing. Some excluded data can be of variable reliability, may be prospectively filtered by software, or may otherwise be omitted from the patient report because of professional interpretation and judgment. One can legitimately argue that this interpretation and judgment, as reflected in the patient report, should serve as the gateway to the official medical record.
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UNC Geneticist Comments on Testing Laboratories' Duty to Return Genomic Data to Patients
UNC's Karen Weck responds to my previous GLR post:
I agree in principle that patients have the right to access their genomic data; however, in practice it is much more complicated (as things often are). Giving a patient his/her raw sequencing data would be meaningless – it is the interpretation of the clinical significance of sequence data that is important when reporting results. This latter requires the expertise of molecular genetic laboratorians and clinical geneticists. We do not return all genomic sequence variants to individuals in exome sequencing, for example when we determine that they are unlikely to be contributory to their disease or medical health. It is important to those of us doing this that we retain the ability to use our professional judgement to determine what should be reported to patients as medically relevant, primarily so as not to dilute important medical information with irrelevant information.
Karen E. Weck, MD
Professor of Pathology & Laboratory Medicine and Genetics
Director, Molecular Genetics
University of North Carolina at Chapel Hill
ACLU v. Myriad Genetics, Round 2: The Problem of Governance-by-Guidance
Just about everyone interested enough in genomics and the law to read this post will know that the American Civil Liberties Union waged a long and ultimately successful legal campaign to invalidate Myriad Genetics' patent claims to isolated BRCA genes, mutations of which are linked to breast and ovarian cancer. Now the ACLU has launched a second front, this time attacking Myriad's post-patent business model of maintaining its vast and unique database of genotype-phenotype associations as a trade secret. GLR reported on that evolving strategy two years ago.
The new ACLU attack has, thus far, received modest attention in the scientific press, and some of what has been reported is inaccurate. In this post I will briefly review what has actually happened and then try to sort out fact from fiction in the reportage. The bottom line is that the federal government has not created new stealth regulations dealing with the disclosure of genomic data to patients. It has, however, used the practice of governance-by-guidance to make significant new policy, which is problematic enough in its own right.
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Genetic information as "perceived disability": Chadam v. PAUSD
Chadam v. PAUSD, as previously covered on Genomics Law Report, is a case in which parents of a school boy are alleging that a school district violated their son's rights when it made the decision that it would transfer the boy to another school because of his genetic information. Specifically, the allegation is that when the boy moved to the area and registered for school, (1) the school district learned of the boy's genetic information related to cystic fibrosis, (2) the boy was regarded as disabled by the school district, and (3) on the basis of this perceived disability, the school district decided to transfer the boy to another school to protect two other students at the school who have cystic fibrosis. The school district's decision was apparently based on the idea that the boy, because of his genetic markers, posed a cross-infection risk to the students with cystic fibrosis. Individuals with cystic fibrosis, because their respiratory symptoms create host environments favorable to microbiological pathogens, are often separated from one another to minimize risk of spreading germs to one another. Mere carriers of the genetic markers associated with cystic fibrosis do not pose such cross-infection risks.
This case unequivocally does not involve GINA, a federal nondiscrimination statute that has very limited scope and does not protect individuals from discrimination in education. While the facts alleged could have supported a clear claim for violation of California's genetic nondiscrimination statute, CalGINA, which affords broader protections than the federal statute, the attorney for the Chadams did not raise that claim. Instead, this case alleges violations of two federal antidiscrimination statutes, the Americans with Disabilities Act (ADA) and Section 504 of the Rehabilitation Act. Title II of the ADA requires public education to be free from discrimination, and Section 504 requires all federally funded programs and activities to be free from discrimination. Under both provisions, individuals cannot be excluded from participating in or enjoying the benefits of education because of disability. The statutes protect three basic classes of individuals: (1) those who have a disability (i.e., those who have a physical or mental condition that substantially limits a major life activity); (2) those with a history or record of having a disability; and (3) those with a perceived disability (i.e., those "regarded as" having a disability). (For more information, see A Guide to Disability Rights Laws published by the Civil Rights Division of the US Department of Justice)
The plaintiffs in Chadam have appealed the trial court's decision to grant the school district's motion to dismiss the case (a Rule 12(b)(6) motion). In granting the school district's motion, the court basically decided that even if it assumed all of the facts alleged by the plaintiffs to be true and drew all reasonable inferences in favor of the plaintiffs, there would not be a valid claim upon which relief could be granted. On appeal, the United States Court of Appeals for the Ninth Circuit, which covers California, will focus on whether the district court erred in reaching that decision. The court of appeals will consider the motion de novo—that is, will give no deference to the trial court's decision—and determine whether the facts alleged in the pleadings, when read in the light most favorable to the plantiffs, state a claim for relief that is plausible. The amicus brief filed by the United States (Department of Justice and Department of Education) urges the Ninth Circuit to reverse the district court's decision and remand the case, stating that the plaintiffs have alleged sufficient facts to support a claim of intentional discrimination under Title II of the ADA and Section 504.
Is there judicial precedent for ADA protection of genetic information?
About 15 years ago, long before Congress passed the Genetic Information Nondiscrimination Act, there was a case in which individuals sought ADA protection from genetic discrimination. That case involved the Burlington Northern Santa Fe Railroad (BNSF), which allegedly had been using employees' genetic information in connection with work-related carpal tunnel syndrome claims. The case was never decided by a court, however. In 2001 the Equal Employment Opportunity Commission (EEOC) and BNSF settled the EEOC's request for injunctive relief to stop the company's genetic testing, and in 2002 the EEOC and BNSF settled the request for damages with an agreement to compensate individuals with up to $2.2 million. While the settlement agreement was subject to approval by the Eastern District of Wisconsin (see 2002 WL 32155386), this case did not set judicial precedent that the ADA protects individuals from decisions based on genetic information.
Does the relevant legislative history suggest that individuals are protected from genetic discrimination because of "perceived disability"?
To answer this question, it is useful to start with legal scholar Mark Rothstein's thorough 1992 analysis of the law regarding genetic discrimination and possible protection under the ADA as it existed at that time. See Mark A. Rothstein, Genetic Discrimination in Employment and the Americans with Disabilities Act, 29 Hous. L. Rev. 23 (1992).
In the early 1990s, in a letter to a Congressional committee chair, the EEOC actually rejected the idea that the ADA prohibits genetic discrimination against asymptomatic individuals, instead taking the position that the ADA would only protect an individual once the condition existed and symptoms were present. The EEOC's technical assistance manual in 1992 also noted that genetic predisposition and family history are not "impairments" protected by the ADA. Nearly 10 years later, following the issuance of the Executive Order 13145 in 2000 that protects federal employees from genetic discrimination, the EEOC provided guidance indicating that instances of disparate treatment on the basis of genetic test results or family medical history would support a claim that an individual was "regarded as" having a disability and thus protected under the ADA and Rehabilitation Act.
As a matter of history, Congress and advocates alike did not believe that the ADA or Section 504 were sufficient to protect individuals from genetic nondiscrimination. In the statutory text of GINA, Congress found, "Federal law addressing genetic discrimination…is incomplete in both the scope and depth of its protections." (PL 110-233, Finding 5).
To date, there are no direct cases on point deciding that genetic information is a "perceived disability" under the ADA and Section 504 or, conversely, ruling out that possibility.
What are the implications of this case?
Ultimately, a broad ruling in Chadam that genetic information alone is a sufficient basis to bring an action for "perceived disability" could dramatically expand individual genetic nondiscrimination protection—at least in the Ninth Circuit. Courts in other federal circuits would not be bound by a Ninth Circuit decision and could choose whether or not to follow it. That reality, combined with the strong public reactions to this case, suggests that Congress has important work to do to strengthen genetic nondiscrimination protections in education and other sectors of society currently not addressed directly by federal statutes.
The Patent Dispute Over Gene Editing Technologies: The Broad Institute, Inc. vs. The Regents of the University of California
The patent dispute already called "the biggest in biotech history" is only getting started. On January 11, 2016, Administrative Law Judge (ALJ) Deborah Katz officially declared an interference over patents for the CRISPR-Cas gene editing technologies. An interference is a U.S. Patent and Trademark Office (USPTO) administrative proceeding conducted to determine which of multiple claimants to a particular invention has priority rights. Since the patents in question were filed before the March 2013 effective date of the America Invents Act, priority will be awarded to the claimant who was the first to invent the technology in question. This dispute pits Feng Zhang, the Broad Institute, and MIT against Jennifer Doudna and the University of California-Berkeley as well as Emmanuelle Charpentier, Krzysztof Chylinski, and the University of Vienna. Law professor Jacob S. Sherkow has followed the case closely and has provided useful background information on Stanford's Law and Biosciences Blog.
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Genetic Discrimination Case Against School District is Appealed to Ninth Circuit
As Stephanie M. Lee reported for Buzzfeed in a well-written account (which contains links to the relevant court documents), an appeal was filed in January with the Ninth Circuit Court of Appeals in the case of Chadam v. Palo Alto Unified School District (4:13-CV-04129-CW). At issue in the case is whether the school district violated a boy's rights when it decided to force him to transfer schools. The student's parents allege the transfer decision was because he is a carrier of a genetic variant associated with Cystic Fibrosis or CF (although he has not exhibited symptoms of the disease), and the appeal argues the trial court erred in dismissing the complaint that the school district's decision to transfer violated his rights under Title II of the American's with Disabilities Act or ADA (42 U.S.C.A. §12131 et seq.), Section 504 of the Rehabilitation Act of 1973 (29 U.S.C.A. § 794), and the First Amendment of the U.S. Constitution. At the trial court level, the school district successfully defended its decision to transfer the boy by arguing it relied on medical advice and made the decision in an attempt to protect other children at the school who have CF.
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Australian appeals court upholds patents on isolated BRCA1 DNA
Robert Cook-Deegan, MD
On September 5, the Federal Court of Australia (the appeals court) upheld a claim on isolated DNA from the BRCA1 gene. It dismissed Yvonne D'Arcy's appeal of a case that has attracted international attention. Australian patent 686,004 has never been enforced, so the court decision has little real-world concrete impact. As Richard Gold and Julia Carbone explained in their classic case study, "Myriad Genetics: In the Eye of the Policy Storm," the patent rights on BRCA1 and BRCA2 were exclusively licensed for use in Australia and New Zealand to Genetic Technologies, Ltd. (GTG), which in turn made them a "gift to the people of Australia." When the CEO of GTG proposed taking back that gift in the summer of 2008, he provoked a firestorm and the company backed down in October, restating that it would not enforce its patent rights against laboratories offering BRCA testing. The Australian Senate held a series of hearings, and a bill proscribing DNA sequence patents was proposed, but the new government opposed it, and it lapsed. Instead, Australia enacted patent reforms in 2012 that raised the bar for utility and clarified the Australian law's exemption from infringement liability for research and regulatory approval. Most of the provisions of that law took effect on April 15, 2013, the very day Association for Molecular Pathology v Myriad Genetics (AMP v Myriad) was argued before the U.S. Supreme Court.
Long-Awaited Announcement from the FDA on LDTs
On July 31, 2014, the FDA gave Congress notice that in the next 60 days it would be announcing draft guidelines on the regulation of laboratory developed tests (LDTs). This topic has been discussed on the Genomics Law Report frequently for years. [You can access the previous coverage here].
The "Anticipated Details of the Draft Guidance for Industry, Food and Drug Administration Staff, and Clinical Laboratories: Framework for Regulatory Oversight of Laboratory Developed Tests (LDTs)" mark a large expansion of FDA regulatory activity into industry practices that have been–depending on your perspective on the scope of the agency's regulatory power—enjoying the FDA's discretionary forbearance from regulation or taking place just outside of FDA's regulatory reach. Indeed, aside from a few "it has come to our attention" letters in Summer 2010 and the second, more forceful warning letter issued to 23andMe in Fall 2013, the FDA has not taken action against companies providing individuals with direct-to-consumer (DTC) access to their personal genetic/genomic information.
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text:
ARL 17477 dihydrochlorideCat. No. 3319 |
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Chemical Name: N-[4-[2-[[(3-Chlorophenyl)methyl]am |
Biological Activity
Selective neuronal nitrogen oxide synthase (nNOS) inhibitor (IC50 values are 1 and 17 μM for nNOS and endothelial NOS respectively). Reduces ischemic cell damage after middle cerebral artery (MCA) occlusion in rats. Displays a synergistic neuroprotective effect when combined with either an NMDA or AMPA receptor antagonist.Licensing Information
Sold with the permission of AstraZeneca UK Ltd.The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
O'Neill et al (2000) ARL 17477, a selective nitric oxide synthase inhibitor, with neuroprotective effects in animal models of global and focal cerebral ischaemia. Brain Res. 871 234. PMID: 10899290.
Hicks et al (1999) Synergistic neuroprotective effects by combining an NMDA or AMPA receptor antagonist with nitric oxide synthase inhibitors in global cerebral ischaemia. Eur.J.Pharmacol. 381 113. PMID: 10554878.
Zhang et al (1996) ARL 17477, a potent and selective neuronal NOS inhibitor decreases infarct volume after transient middle cerebral artery occlusion in rats. J.Cereb.Flow Metab. 16 599.
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Jonathan Jennings, Daughters of 1812
CORYDON – The Jon-athan Jennings Chapter, United States Daughters of 1812, held its February meeting in Corydon with Carol Seales, president, presiding, using the national society ritual.
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Crate issues at night, 5 month old French Bulldog
Hey guys,
So I have a male French Bulldog at home. He is going to be 5 months next week. I am having some crating issues with the little guy at night. Basically he is pooping in his crate at 4-5 am. Yes the crate is small and is the proper proportion for the dog. Ive owned another dog before. He is pee pad trained right now and soon to be learning to be outside. He does go for small walks as it is really cold over here in Canada. Im looking for some advice or tips to help stop him from pooping in his crate. During the day when he is crated he does not poop. He used to, but not anymore as I only go out a couple of hours and then let him out for like 3-4 hours. Any advice would be appreciated. |
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text: Dorium 134,620pages on this wiki Add New Page Edit Edit source History Talk0 Share This article contains information that originated from an unlicensed Star Wars Legends source. This article's subject originated in a source that was released outside of the Lucas Licensing process, and its licensing status was never confirmed by Lucasfilm Ltd. Dorium was a radioactive ore found below the crust of the planet Zender. SourcesEdit "Plus froid que l'espace"—Casus Belli HS12 Ad blocker interference detected! Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers Wikia is not accessible if you've made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected. Categories: Legends articlesArticles from unlicensed sourcesOresSubstances


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If you happen to be flying American Airlines in the next few weeks, you might see my name briefly mentioned in an article about NaNoWriMo. For the earthbound set, there is the online version.
Funny how I have more distribution power on my little computer than Gutenberg did back when he was pulling proofs of the 42-line bible, but it is still exciting to see your name in print. Print that ran in presses and smells like ink.
The reporter, Angela Chang, asked me about opposition to NaNoWriMo during my interview. I was a little surprised. I mean, there is a lot to be annoyed by in people's self-rightoues interest in themselves and everything they output. But even a cynic like myself has a hard time seeing a downside to giving people a forum to start writing, no matter the outcome.
Eric Rosenfield does. He wrote a post with the commanding title "Why I Hate NaNoWriMo, and Why You Should To." Mr. Rosenfield didn't convince me. Nor his readers, judging by the comments. But this one thing I couldn't leave alone:
[NaNoWriMo] pollutes the world with volumes upon volumes of one-off novels by people who don't really care about novel writing.
Unless he has trouble keeping himself off the animated-gif homepages of hundred's of Live Journal users, I'm not sure what the pollution is. Bits are cheap and plentiful. And if the books make it past the publishing phase, then the beef isn't with the instigating month, but the publishers who put out such work.
I suspect Mr. Rosenfield is pining for a more monastic writer. It seems to me he attaches the romantic aesthetic to the process, which is understandable because a great many writers do as well. Maybe he's thinking of a writer of great talent and mystery like William Gaddis. Hard to imagine him dashing anything off so casually. But then, it's not so hard to imagine Kerouac doing it, or Fitzgerald. Tolstoy, no. Dumas, yes. Need we go on? The field of the written word is so massive that it seems ludicrous to try and contain it within your own small vision of what should and shouldn't be.
Francis Ford Coppola once claimed that the next great American movie might just come from a teenage girl in an Iowa cornfield. I say the next great American novel might just come from a young writer up against the time clock with NaNoWriMo. It will be a novel of its time. It will certainly be a novel of its technology.
As the word changes and evolves with the changes in our culture, and by the new means of communication, what a novel is will change. Perhaps that's disturbing to Mr. Rosenfield, but I find it exciting.
And, of course, I'm thrilled to be a part of it all again. My screen name is Mr. Lowry and, as usual, I have an excerpt up.
Posted by: Martin McClellan
On the date of: November 4, 2007 10:20 PM
Posted by: Kent M. Beeson | November 7, 2007 09:33 AM


text: steve hughes: offended Click to block a category:GamingPoliticsNewsComicsAnimeOther User has deleted their account. next random Comment Top NextComment You need to login to view this link - where you discover what's really going on!... Steve Hughes on the absurdity of political correctness, and health and safety! Follow on Twitter: You need to login to view this link Follow/Like on Facebook: www.facebook.com/pages/Vox-Rox/200976699936194 next +12 Views: 1450 Submitted: 04/02/2012 Facebook Twitter Google+ Tumblr Pinterest