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(Soblidotin; TZT 1027; TZT-1027; TZT1027)
Auristatin PE Chemical Structure
Bulk Inquiry
Product name: Auristatin PE | |
Cat. No.: HY-14672 |
Auristatin PE is a novel synthetic Dolastatin 10 derivative and inhibitor of tubulin polymerization.
Target: Tubulin[1]
InVitro: Auristatin PE (TZT-1027) is a novel synthetic dolastatin 10 derivative that inhibits tubulin polymerization. Auristatin PE exhibits antitumor activity against p-glycoprotein-overexpressing cell lines established from colon cancer H116 and breast cancer-resistant protein-positive cell lines established from lung cancer PC-6, and is more potent than Vincristine, Paclitaxel, and Docetaxel against these cell lines[1]. Auristatin PE (Soblidotin) is a synthetic analog of dolastatin 10 which inhibits the growth of several tumoral cell lines and induces caspase-3-dependent apoptosis. Auristatin PE also shows antitumoral activity in Vincristine-, Docetaxel-, and Paclitaxel-resistant tumors, which makes it a potential chemotherapy drug for use in tumors which do not respond to other microtubule inhibitors[2].
InVivo: Intravenous injection of Auristatin PE (TZT-1027) has been shown to potently inhibit the growth of P388 leukemic cells and several solid tumors in mice, and to prolong the survival of the animals, and its antitumor efficacy has been shown to be superior or comparable to that of the reference agents Dolastatin 10, Cisplatin, Vincristine, and 5-Fluorouracil. Furthermore, in xenograft models, Auristatin PE reduces intratumoral blood perfusion 1 to >24 h after its administration, thereby producing hemorrhagic necrosis of the tumors[1]. Auristatin PE (Soblidotin) shows antivascular effects in tumoral models overexpressing VEGF and in murine colon tumors, with an increase in vascular permeability, vessel closure, and widespread hemorrhage[2]. Mice bearing subcutaneous HT-29 tumors (200 mm3) are dosed every 7 days with Auristatin PE (0.5 or 1.0 mg/kg) for a total of four cycles. Under such conditions, Auristatin PE (TZT-1027) inhibits the growth of HT-29 xenografts in a dose-dependent manner. Coadministration of Auristatin PE does not interfere with the PD184352-induced suppression of ERK1/2 phosphorylation. Immunostaining for Ki-67 as a marker for proliferating cells confirmed that the number of such cells in tumor sections is decreased greatly at 24 hours after the initial dosing with PD184352 compared with that apparent for vehicle-treated tumors . Auristatin PE treatment alone increases the number of TUNEL-positive cells in HT-29 xenografts by 24 hours in a dose-dependent manner, and this effect is enhanced by coadministration of PD184352[3].
M.Wt | 701.98 | Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Formula | C₃₉H₆₇N₅O₆ | ||
CAS No | 149606-27-9 | ||
Solvent & Solubility | 10 mM in DMSO; Methanol: ≥ 44 mg/mL |
1 mg | 5 mg | 10 mg | |
1 mM | 1.4245 mL | 7.1227 mL | 14.2454 mL |
5 mM | 0.2849 mL | 1.4245 mL | 2.8491 mL |
10 mM | 0.1425 mL | 0.7123 mL | 1.4245 mL |
10-Deacetyl-7-xylosyl paclitaxel is a Paclitaxel derivative with improved pharmacological features and higher water solubility.
10-Oxo Docetaxel(Docetaxel Impurity) is a novel taxoid having remarkable anti-tumor properties and a Docetaxel intermediate.
2-methoxyestradiol (2ME2; NSC-659853) is a natural metabolite of estrogen that is known to inhibit HIF-1 alpha with an IC50 of 0.71 (plusmn) 0.11 (mu)M for the inhibition of BPAEC migration.
4(acute)-Demethylepipodophyllotoxin(4(acute)-DMEP) is a key intermediate compound for the preparation of podophyllotoxin-type anti-cancer drugs; a potent inhibitor of microtubule assembly.
7-Epi-10-oxo-docetaxel (Docetaxel Impurity D) is a impurity of docetaxel detected by high performance liquid chromatography (HPLC).
7-Epi-10-oxo-docetaxel (Docetaxel Impurity C; 7-Epitaxotere) is a impurity of docetaxel.
7-xylosyltaxol(Taxol-7-xyloside) is a taxol (Paclitaxel) derivative; Paclitaxel binds to tubulin and inhibits the disassembly of microtubules.
ABT-751(E 7010) is a novel bioavailable tubulin-binding and antimitotic sulfonamide agent with IC50 of about 1.5 and 3.4 (mu)M in neuroblastoma and non-neuroblastoma cell lines, respectively.
Auristatin E is a cytotoxic tubulin modifier with potent and selective antitumor activity; MMAE analog and cytotoxin in Antibody-drug conjugates.
Auristatin F is a cytotoxic tubulin modifier with potent and selective antitumor activity; MMAF analog and cytotoxin in Antibody-drug conjugates.
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We loved it there. Our kids especially loved both inside the house and all the surrounding kid-friendly decor. Was a wonderful weekend!
Sam2017-02-27T00:00:00ZWe stayed at Suzan's place for 4 nights and it was great! Suzan was very communicative and made sure we had everything we needed. The house itself is setback in a nice wooded area. It has a nice master bedroom and a loft with a bed that is great for 2 couples, a small family or just a small group of friends. The kitchen is fully stocked and very clean. Suzan lives on site in her own cabin but left us to ourselves unless we needed something which was really nice. We went to squaw valley for 2 of the days we were there. We left at 7:30am and was on the mountain by 8:15am so even though it's not in Tahoe proper it was still close enough to still get good round of snowboarding in. Additionally the last day we were there some weather was pushing through but because we were on the west side of the peak we didn't have to deal with the traffic and slowdowns that normally happens over the peak. Thanks Suzan!
Jordan2017-01-01T00:00:00ZSuzan was the most gracious host we have encountered. She greeted us upon arrival and gave us a tour, telling us where everything was and saying she would be available for anything we might need. It had snowed the previous night and the road was a bit difficult to navigate in our sedan, so Suzan offered to have her son work down the road to a more manageable level. She could not have been more accommodating. Her home was beautifully decorated for the winter season, the house was clean, had just about everything one would need, with wifi, modern appliances and beautifully decorated with pieces from local craftsmen and Suzan's own family. The grounds house a full size barn, a fire pit, and a clearing large enough for bonfires with tall pines all around. The outside was decorated with tiny, white fairly lights that play into the theme of the name. Close to the charming town of Dutch flats, this is the perfect place to travel when you want a bit of seclusion, but want to be close to Truckee, Tahoe City, or Sugarbowl resort. We will absolutely be back!
Brian2017-01-09T00:00:00ZThis is a very cozy cabin with a beautiful fireplace. It was the perfect mountain getaway for us and our dog. The only thing to note is that there is little to no cell service at the cabin, however the wifi worked great. We look forward to planning another trip soon!
Laura2017-02-06T00:00:00ZThe perfect getaway! It was a winter wonderland! Suzan was the best host, good communication and very friendly. Will definitely be coming back.
Wes2017-01-30T00:00:00ZWe had an amazing time and would love to keep Suzane's wonderful home a secret but others deserve to experience her wonderful hospitality. Thanks Suzane
Don2017-02-21T00:00:00ZSusan warmly greeted us when we arrived and showed us around. It was nice to have tea in the cupboard and all the dishes/cookware we needed in the kitchen. We stayed over Christmas and the cottage was decorated with lights outside with a lit wreath on the barn in the courtyard. Plenty of firewood.
Brad2016-12-29T00:00:00ZArt der Unterkunft
Ganze Unterkunft
Unterkunft für
Alta, Kalifornien 95701, Vereinigte Staaten
An incredibly beautiful spot at the precipice of a large valley, and a super cozy cabin! The view was breathtaking, this is a really special place. Sandy was a gracious host.
Maggie2016-10-11T00:00:00ZEs el lugar más tranquilo y apartado de todo en el que he estado. Las vistas son espectaculares y el anfitrión estuvo en todo momento pendiente de nuestra llegada, y también muy disponible por si necesitábamos cualquier cosa.
Raquel2017-01-03T00:00:00ZPlace is so gorgeous. Owners are very nice and friendly. This is full B&B. It was so nice to find cool drinks in cooler after long day of hike. I would like to visit this place again. Thank you so much for so warm reception.
Alex2016-07-03T00:00:00ZSandy's cabin is beautiful. It has everything you need for a nice weekend visit. She gave us plenty of privacy which was greatly appreciated and was very welcoming. Alta's scenery is amazing and breathtaking. I would highly recommend, especially for couples!
Angel2017-01-08T00:00:00ZWe had a great time here. Beautiful, nature, close skiing, peaceful retreat. Host was very helpful and friendly.
Marco2016-12-20T00:00:00ZSandy and Gordon, our hosts, were incredible. They were generous, welcoming, and very available. They let us borrow some things from them, had many delicious snacks and beverages available, and were very thoughtful in anticipating our needs without being obtrusive at all. There's a lovely porch you can hang out on and eat breakfast with a view of the mountains. There's a microwave, fridge, and hot plate to make a simple breakfast. There's a great restaurant for dinner not too far away, and the Yuba River is about 20 minutes away by car in Big Bend. The best lake spots require a four-wheel drive, but there are other lakes to visit for swimming and kayaking. The bed was comfortable and I slept really well, but my partner woke up from the sound of the trains. The cabin is really secluded, and it felt wonderful to get away.
Aimee2016-08-03T00:00:00ZMy husband and I had a wonderful, peaceful time at the Casa Loma cabin. Sandy was more than helpful with directions and ideas about what to do in the area, and the cabin had plenty of thoughtful touches. We enjoyed the cold drinks in the fridge on our back deck taking in the MARVELOUS view! Will definitely be adding this to our list of getaway spots.
Christina2016-08-14T00:00:00ZSandy communicated with us before our stay to make sure we knew exactly where to go. She was very inviting when she greeted us and gave us a tour of the cabin. The cabin itself is super cute and cozy, exactly as described and pictured. It is secluded and private, nice balcony to watch the sunset in the valley. We slept longer than planned as it was raining and the bed was cozy and warm. I look forward to staying again and highly recommend it.
Deanna2016-10-30T00:00:00ZArt der Unterkunft
Ganze Unterkunft
Unterkunft für
Alta, Kalifornien 95701, Vereinigte Staaten
This house/cabin is amazing! Clean, well stocked, everything a family could ever want, from music Ipod (9000+ song list), fully stocked kitchen, toys, even scrap paper for kids to draw. Comfortable beds, beautiful views, lovely deck , and a firepit! Also a barbque (with a charcoal starter). There are even dog bowls. It is so quiet you think you are a million miles from everything . Wonderful! We highly recommend it! You will love it!
Suzanne2015-09-23T00:00:00ZBetter than in the photos. A special place.
danielle2017-02-21T00:00:00Z5/5 stars!! I was entirely satisfied with everything about our stay in this cabin! It was a perfect get away weekend! The cabin was beautiful, forest was amazing, cleanliness was excellent, their were games, excellent washer/dryer to bring clean clothes home, and just all around more than what we could have asked for! TJ was an amazing host. Very quick responses, he took the initiative to keep us updated on our concerns of the weather (we wanted snow and he let us know as much as he could), and he was very accommodating to all of our needs and really was just a pleasure to plan with. Even in our time of getting stuck in the snow his neighbor was quickly available and saved the day! TJ has definitely earned our business again and again in the future! I can't express how perfect the trip was!
Ryan2015-12-16T00:00:00ZWe stayed at the cabin for 2 nights over the MLK day with our family friends. I remember the first thing I noticed about the cabin was how great the place smelled from the natural wood they used throughout the cabin, which reminded me of getting a fresh Xmas tree! We noticed how thoughtful the hosts are by making a book and post cards of things to do nearby. We were also very impressed by the photo book that told the story of how they transformed the place from a gem in the rough to a true diamond. The cabin decor was classic and tasteful with all the high end amenities you'd need to enjoy the stay comfortably. We loved how "isolated" the cabin is to feel like we got to escape from the city to really immerse ourselves in nature. Our kids had a great time exploring in the woods, playing in the treehouse, the swings and starting a camp fire in the backyard. They also got to play with the Legos and other toys at night time. Without traffic, the drive to Sugar Bowl was a breeze! It's a great place for families with little ones. We'd definitely like to stay there again.
Cathy2015-01-27T00:00:00ZTj and Siobhan couldn't have been better hosts. They were in touch before our trip, quickly responding to questions we had and were helpful in suggesting a restaurant for my husband's birthday dinner. The on-line guide was great to peruse before we got there, but the real gem was the compilation of trail maps and description of area hikes - they clearly put a lot of time in organizing a fabulous tool for their guests. We were especially impressed with their concern for our experience when a wildfire broke out in the area during our stay. It didn't threaten their property, but they were kind enough to offer to not hold us financially responsible for the rest of our stay, if we felt we needed to leave. Luckily, the air quality held out until the day we were headed home anyway - we would have hated to have to give up any time at Fool's Gold! The neighborhood (if you can even call it that) was incredible - peaceful and quiet - fabulous for sitting on the deck in the morning with a cup of coffee, then a glass of wine at the end of the day. The cabin is beautiful - lovely and open main living area - great sound system. Can't wait to go back!!
Deborah2015-08-03T00:00:00ZThe cabin and location is just so peaceful and forces you to unplug as much as one possibly can. Time to just enjoy the mountains and fresh air, away from the crowds. It was my second stay, and the improvements just continue to delight. I look forward to staying again.
Laura2016-08-01T00:00:00ZTJ and Sioban were very attentive, sending us a welcome email before arrival to make sure that we had the correct directions, and answer any questions we may have. The house was perfectly as described, and fully stocked-ehough games and toys for our 5 year old (but enough for a wide age range). We had all of the necessary cooking equipment and some condiments. The house had a large play area and the tree house, ping pong table and fireplace and bbq were just perfect for out weekend. We will definitely come back!
Ariana2016-09-18T00:00:00ZWhat a peaceful and private location. My wife and I really enjoyed our stay here. T j & Siobhan have really done a wonderful job with this property. Very warm and comfortable with all the right amenities. Great suggestions for activities in the area including hikes with detailed directions and maps. We'll return again to enjoy the tranquility and connection with nature.
Gregory2015-08-24T00:00:00ZArt der Unterkunft
Ganze Unterkunft
Unterkunft für
Alta, Kalifornien 95715, Vereinigte Staaten
We had a great time at Diane's cabin. Diane was a great host - explained everything about the house, was accessible when needed, but stayed out of the way otherwise. The cabin is very well located - very close to the I-80, yet very quiet and private. There are great hiking trails starting almost from the house (the walk down to American Canyon is strenuous but highly recommended), and the house has lots of activities for families: a ping pong table, a basketball hoop, a badminton court, an outdoor hot tub, games and more. The house is a bit old, but still charming. It is spacious, clean, and well appointed. Overall, highly recommended for a family or two to share.
Yair2015-04-13T00:00:00ZDiane was an amazing hostess and my group and I had a really great time during our stay. The property is beautiful and cozy and Diane was super helpful in suggesting various places to go. I would definitely recommend staying here and would love to book with Diane again in the future.
Chandra2014-09-16T00:00:00ZWe had a lovely time at the Gold Run House over Thanksgiving weekend. The cabin is spacious yet feels cozy, and the forest all around makes you feel quite secluded. I was impressed with the cabin's size and the feel of its decor and aesthetic. We loved exploring the hiking trails just up the road and the walking tour of historic Dutch Flat, a little further up the road! Even though it rained most of our second day, we had a great day watching old movies from Diane's collection, playing board games, and soaking in the tub while the rain fell around us. Diane made us feel very comfortable, answering all of our questions and making sure we had access to ample firewood to keep the place cozy. She was very accessible by text or by just walking up to her house nearby. There are two main bedrooms that are good-sized as well as an upstairs with several beds, so we were able to accommodate some friends who were passing through the area. The Wi-Fi was a bit spotty in the living room, but worked well in the game room and the master bedroom. Overall, I highly recommend staying here if you're looking for a relaxing weekend with friends and/or family in a secluded mountain location!
Ariel2016-11-29T00:00:00ZDiane's place was really great! We had no problem fitting our small group in the lodge, but there were plenty of beds, and pull out beds in the closet for more people. Everything you could have possibly needed was provided. Overall a great place to stay!
Mandy2017-02-27T00:00:00ZWe had a great time staying at Gold Run. The location is quiet and in the woods. There are hiking trails nearby, and all in all a great place for an escape from the city. We were very tickled by the fact that there were robes hanging in the bedrooms for maximum lounging capability. Kitchen had everything necessary to cook several meals. While we were a party of four, the house had plenty of capacity and extra beds tucked in every corner for more people. Diane was a warm and gracious host with clear instructions for everything posted around the house. Success!
Kelsie2015-02-18T00:00:00ZArt der Unterkunft
Ganze Unterkunft
Unterkunft für
Gold Run, Kalifornien 95717, Vereinigte Staaten
David was an exceptional host and the property was absolutely breath taking. I would recommend this to anyone who appreciates the outdoors as much as I do and wants somewhere to get away from it all. His instructions in the itinerary were spot on and I have nothing negative to say about my experience.
Christopher2015-11-03T00:00:00ZSuch a great place to stay, beautiful view and amenities. Our group was very pleased and would definitely use this AirBnB again! Recommended for any vacation. Thank you!
todd2015-07-23T00:00:00ZStunning. Beautiful home on an even more beautiful property. My girlfriend and I stayed at David's place over a ski weekend in late January, and we would do it again in a heartbeat. Without traffic we were only 30 minutes from Sugar Bowl (warning: can be much longer than 30 if you hit ski traffic). We reserved our entire last morning for sipping coffee and reading on the property's overlook - breathtaking. 10/10.
Michael2017-01-30T00:00:00ZDavid was responsive, and directions to the place were clear and easy. This property is outstanding - space, views, clean and well-appointed. I've rented tons of places (through other sites, new to airbnb), and I've never gone back to any of them (some were great, of course, but not great enough to warrant a 2nd visit, i just love seeing new places too much) - this is the exception. I'm really looking forward to coming back. The train tracks add an extra special touch I wasn't expecting, and the property is big enough to wander into the forest and get lost. Highly recommended.
Tyler2015-10-28T00:00:00ZWhat a beautiful property! David was very responsive and flexible with all of my needs. The place was comfortable and he even left wine and spirits for us to help ourselves. Beautiful patio observatory deck and I loved the privacy to get away from it all! Thanks David for being an awesome host!
Joseph2015-08-11T00:00:00Zgreate place to live
yun2017-03-01T00:00:00ZThe place was spectacular. We came up during the summer to get away from it all and this property provides that. The whole property to yourself and an amazing front row seat for stargazing at the observation deck.
Michael2016-08-16T00:00:00ZBeautiful extremely private property. The sleeping accommodations aren't comfortable and lack privacy. Beyond that, the cabin is clean, and cozy with character. It's perfect for a small family only getaway. The host is communicative and helpful.
russell2016-11-28T00:00:00ZArt der Unterkunft
Ganze Unterkunft
Unterkunft für
Alta, Kalifornien 95701, Vereinigte Staaten
My boyfriend and I had a great time staying at Susie's! The place was very quiet and cozy. We had our own bedroom and bathroom in the upstairs area where the kitchen/ living room was, and Susie was downstairs in her apartment. She came to greet us but then let us be for the rest of our stay. It was a 45-minute drive from Sugarbowl mountain, so perfect for us. I would definitely stay here again!
Jenna2016-02-15T00:00:00ZSusie was very kind to welcome us at the door even though we were late in the evening getting to the place. She had arranged for the breakfast items - bread, butter, milk, juice, eggs, etc so we were able to have breakfast before leaving for the slopes for snowboarding. Susie made sure that were comfortable and had everything we needed, and the place is very warm, and cozy. Bed was comfortable. Susie is a really wonderful artist and her work is on display in the room. Gives the place great character. Certainly would like to return back. Thanks Susie!
m2016-04-04T00:00:00ZSucie's home is very spacious, clean and cozy. It locates conveniently close to highway I80 while very quiet in this neat village. We had a very comfortable night in Sucie's home. Sucie is nice and considerate, and she had prepared specially for my 3-year-old son the picture books and drawing sets, which made him spend the evening happy and fun. We will be delighted to stay again next time.
Monica2016-02-18T00:00:00ZWe had an absolutely wonderful time in Susie's home! It was the perfect spot for a quick ski getaway -- close to the skiing but tucked away in a quiet little mountain town with a killer sunset view. The home itself is gorgeous, and we had the whole upstairs to ourselves, to include the well-equipped kitchen. Susie was super friendly -- we had a fantastic time and would love to return someday!
Eric2016-03-03T00:00:00ZHad a short but great stay at Susie & Ross's! We arrived late at night but Ross was so kind to open up and explain their place to us. He even offered us breakfast! Communication with the two was seamless; the room comfy, everything very clean and tidy... Would absolutely recommend!
Moritz2016-08-08T00:00:00ZArt der Unterkunft
Unterkunft für
Dutch Flat, Kalifornien 95714, Vereinigte Staaten
Art der Unterkunft
Ganze Unterkunft
Unterkunft für
Dutch Flat, Kalifornien 95714, Vereinigte Staaten
Art der Unterkunft
Ganze Unterkunft
Unterkunft für
Grass Valley, Kalifornien 95945, Vereinigte Staaten
Art der Unterkunft
Ganze Unterkunft
Unterkunft für
Nevada City, Kalifornien 95959, Vereinigte Staaten
Art der Unterkunft
Ganze Unterkunft
Unterkunft für
Alta, Kalifornien 95701, Vereinigte Staaten
Fantastic communication from our host about planning our stay, a binder of information and maps about Nevada City when we arrived, and a clean/comfortable cabin in the woods!
aimee iris2016-08-05T00:00:00ZWe had a wonderful weekend. Beautiful cabin in the ponderosa forest. Thank you.
Carlos2016-07-19T00:00:00ZWhat a great little cabin! Comfortable, cozy, clean and quiet. Judi was in the process of returning from abroad when we arrived, so communication was sparse, but there were no problems whatsoever. We were worried that we would be too hot during the heat wave, but the cabin stayed nice and cool, even in the 95 degree heat. It's an easy walk to the lake, which is very pretty. If you're there in late summer, as we were, you might want to bring something to float around on, as the boat rental closes in mid-August and the lake is worth exploring.
Carol2016-08-21T00:00:00ZI had a great experience choosing this place. The cabin was very spacious for two people and very clean. The location was also nice because it was quiet.
Jose2015-09-09T00:00:00ZI enjoyed a wonderful vacation at cozy cabin. Once I arrived just the smell of pine and cedar was heavenly. I loved the cabin, especially the large windows in the living room and kitchen area. I liked the feeling of being isolated even though there are very nice neighbors nearby.
Theresa 2016-08-29T00:00:00ZWe loved Judi's place. The cabin stayed nice and cool as it was covered by trees. The neighborhood was very quiet. We walked to the lake every day and the kitchen was very well equipped for cooking nice meals at home. This place has everything we needed.
Lisa2016-07-22T00:00:00ZThank you, Judi, for making our stay at Cascade Shores such a great experience, and for being so attentive to our needs. The cabin was just as comfortable as it could be and, because of its proximity to Scotts Flat Reservoir, we loved our daily strolls down to the shore. We also enjoyed the walk up Pasquale to the part of the lake near the dam. What a beautiful peaceful place.
Melanie2016-10-01T00:00:00ZWe were looking for a place to "get away" for my birthday and Judi's place was perfect. The cabin's tucked away from the road - surrounded by big, beautiful trees. It was peaceful and enjoyed listening to the birds when they were singing. Walking to the lake was a breeze and when we wanted more of a hike, there were clear directions to access a different part of the lake. The kitchen was great for cooking and happily made every meal there. If you're looking to unplug, I highly recommend it!
Alysa2016-06-27T00:00:00ZArt der Unterkunft
Ganze Unterkunft
Unterkunft für
Nevada City, Kalifornien 95959, Vereinigte Staaten
We had a fabulous trip staying at Peggy's place. The house exceeded expectations! It's much nicer than the photos. Very comfortable with all the amenities. The kitchen, deck, hot tub, and grill were amazing. So peaceful to sit in the yard. A quick walk to the lake and a short trip into town or the yuba River. Peggy went above and beyond to make us feel welcome and comfortable. She even left groceries and San toys for the kids! Thank u Peggy!
Kristin2016-07-06T00:00:00ZMyself and some friends and our young children had such as great time staying at Peggy's beautiful lake house. The photos did not do the place justice. Communication was fantastic with Peggy before and during our arrival and she went above and beyond to make sure we had everything. The house is clean, spacious and well equipped with a nice kitchen and large family room. The 3 bedrooms and 3 bathrooms ensures that everybody has there own space. There are rafts and toys for the lake that we didn't end up using as we spent our time on the Yuba river but it was nice to know they were there. There were plenty of clean towels and sheets for all the beds and the location is nestled amongst beautiful trees where we enjoyed looking at the stars at night. I had told here we had 2 infants with us and she installed a child gate on the back deck which was totally unexpected and says a lot about her. We look forward to coming back next year.
Benjamin2016-08-17T00:00:00ZPeggy was absolutely wonderful. And a super nice lady. The house was very nice and clean. Better than the photos. The area is nice and safe feeling. Only a few houses from the lake. We would definitely recommend staying there.
Jan2016-08-30T00:00:00ZWhat an gorgeous home, perfect location, and amazing above-and-beyond host! We really lucked out!!! I stayed here with my partner and my sister, her husband and their daughter and dog for 4 nights. The pictures do NOT do justice to the beauty of this home, its furnishings/ amenities, or its location: it's all much better than what you see described here. Bedrooms are very spacious and the living space (kitchen, dining, and living room) are open and tastefully decorated with super comfy new reclining seats and couch. (4 adults can recline all at the same time - ha ha). The kitchen includes everything you could need including appliances and a full range of utensils and all kinds of supplies. We are a family of bed princesses and found the beds super comfortable and the linens lovely. (maybe worth noticing one queen is a memory foam mattress - the other is very firm and the 3rd bedroom as noted is futon or blow up mattress). The three full baths were equipped with comfy nice towels. The backyard is amazing - with a spacious deck perched and private overlooking the woods, a few big beautiful pines towering over, an outdoor table/ chairs on deck and a lovely outdoor umbrella'd sectional couch down below. All this within a totally fenced yard (so your dog -if you have one- can sniff around while you hot tub). A fantastic place to relax during the day and to grill and hang out together in the evening. Great lake access if you are a morning swimmer and or into boating/ paddleboarding etc. (Peggy provided a ton of water equipment including a paddleboard, toys for kids and more). There are nicer beach areas on Scott's Flat Lake than the boat launch, but I've never seen a rental this close to the lake. This is a wonderful place for a dog - complete with dog crates in bedroom and deck and decks that fence off in front and back... Overall though, what I mainly want to rave about is Peggy: she is unbelievably considerate and on-top of things. Our jaws dropped when we arrived to find a warm peach crisp (made from peaches from the garden tree I think) complete with whipped cream - plus produce from the garden and fresh eggs from a neighbor's hens. Peggy kept in touch and was super attentive to any of our needs and questions, working hard to answer any question or resolve any possible problems. As someone who is perhaps a relatively new AirBnB'er she seems to really be striving to get everything right and rest assured: she is hitting the mark and then some... Thank you Peggy and Scott's Flat Lake Retreat!! We can't wait to come back again!!!
Julie2016-09-05T00:00:00ZPeggy was a wonderful host! My family stayed at her lovely lake house while we were waiting to move into our new home. The house was incredibly clean and comfortable and Peggy made us feel right at home. There were muffins on the counter and orange juice in the fridge and other various things to make us feel welcome and comfortable. Plenty of lake toys for the kids and adults and very accommodating for pets. We would definitely stay here again!
Alaina2016-08-14T00:00:00ZAbsolutely magical house with everything you could possibly want. Games, yoga props, tv, hot tub, fireplace, a million kitchen amenities, you name it the house had it. Peggy was a fabulous hostess, even buying us groceries for the next day when we got in late! The house was beautiful, spotless and so cozy and we had such a great time. The hot tub with giant redwoods all around you was just magical.
Elizabeth2017-02-06T00:00:00ZPeggy's home was exactly as described and she was a very thoughtful hostess! We had a fantastic Thanksgiving week, with everything we needed for a perfect meal. The home was very close to the lake; we were just sorry out was the wrong season to use all of the great water toys.
Jennifer2016-11-27T00:00:00ZPeggy is the best host ever! Truly, this was our best experience with AirBnB. She always made us feel comfortable and welcome. Her house is beautiful too. I checked the "Comfort" box for home accommodations, but it is definitely between Comfort and High End. She was also very helpful as the days led up to our trip, seeing as the weather was looking iffy with snow. It definitely made it less stressful. We had an amazing 5 days in her home, and spent 2 of them in Tahoe. Her house is very close the lake and we spent a morning down there taking in the scenery and snapping some photos. We will definitely come back to this gem!
Tim2016-12-24T00:00:00ZArt der Unterkunft
Ganze Unterkunft
Unterkunft für
Nevada City, Kalifornien 95959, Vereinigte Staaten
Virginia's home was pleasant, clean, and comfortable. The hot tub and back deck were superb. I would recommend staying there.
Walker2015-11-06T00:00:00ZBeautiful home. hot tub was great.
Atlas2015-12-22T00:00:00ZThis flat is a true home share and complete with all the amenities of home. The cabin is full of character, art, and good vibes. The location is very secluded and we enjoyed that aspect of our stay. Deer come by and visit the backyard each day, and the cabin is a short walk to Scott's Flat Lake and very short drive (1 mile) to the trailhead that surrounds the lake. The drive to Nevada City and Grass Valley were 15-20 minutes, and we enjoyed spending our days exploring the quaint downtown streets. With this truly lived in home, the house was not as clean as many of the "made for airbnb" homes I've stayed in before. That being said we stayed over Christmas vacation, so this could have been due to the holiday craziness and not a testament to it's year round condition. Do know that the bed in the bedroom is a futon, which was actually comfortable and yielded full night's rest. Thank you Virginia for hosting us, we truly enjoyed our stay!
Drew2016-12-29T00:00:00ZVirginia's property was very welcoming and the surroundings were gorgeous. We got to see lots of deer roaming right in the backyard and the hot tub was awesome! Virginia's house is beautiful and is decorated from the heart :) Highly recommend!
Nicole2015-11-12T00:00:00ZMy stay at Virginia's place was great! Short walk to the lake. Short drive to Nevada City. The home is clean and comfortable and we had a super relaxing time in the back patio. Would definitely recommend this place!
Adriana2014-08-11T00:00:00ZWe had a great stay at Virginia's home. Very roomy, all the amenities were there. Loved the BBQ on back deck and the hot tub! It was very close to Scotts Flat Lake which was great swimming and great jump off point for all the other places we went to on South Yuba River. Highly recommend this listing! Thank you Virginia. Aengus.
Aengus2015-08-07T00:00:00ZVirginia's house was filthy when we arrived. So dirty in fact that we didn't even feel comfortable staying there and had to scramble to find a new place to stay during our trip. I am not a clean freak by any stretch but renting a house that has kitty litter on the floor, coffee grounds on counters, dirty dishes in sink, dirty hand towels, dead bugs and leaves on the floor, and hair in the bathtub drain keeping it from draining while showering (gross!) is in my opinion unacceptable. I'm not sure what she is charging the $100 cleaning fee for but clearly it is not going toward a professional cleaning. Also, the downstairs bedroom is not really a bedroom at all but rather an office in which a futon has been crammed. Sleepable yes, but not comfortable. Lastly, you may have missed the note in the description about no cell service but this is a pretty big deal if you need to be able to be reached or call someone who isn't local. We were in town because my mother was in the hospital dying and weren't able to call the long distance phone # from the house.
Jessica2016-06-30T00:00:00ZVirginia's place was great! The two bedrooms accommodated 4 people comfortably and the place was well maintained. Overall great experience.
Jose2014-07-10T00:00:00ZArt der Unterkunft
Ganze Unterkunft
Unterkunft für
Nevada City, Kalifornien 95959, Vereinigte Staaten
My fiance and I loved staying at Barrie and Tod's house. We celebrated our engagement here and it was just what we wanted. The lake was beautiful, the canoe was fantastic, and the privacy was perfect - a very romantic place to stay. We really loved the fenced in yard/deck for our little doggie. We couldn't imagine that being any better. We hope to be back!!!
Liz2013-09-13T00:00:00ZThis is a stunningly beautiful house and location! On top of that, the owners are committed to green/eco living, and we enjoyed reading about their house and the various ways they're contributing to preserving the wondrous environment, especially around their place. Highlights included the glass walls that fold back accordion style to completely open the house to the wrap-around deck high about the Rollins Reservoir and surrounded by tall pines/firs. Grilling dinner on the deck. Morning and evening drinks/ meals on the deck. Swimming in the reservoir. They have a canoe, but we didn't take it out. 30 minute drive to Nevada City and the S. Fork of the Yuba River for hiking and swimming in incredible natural pools. Comfy bed and couches, DVD player, beautiful shower. They have a local maintenance man who was available to help with a minor problem with the grill, and any other questions we had. They also have a thorough guide book to the house and environs, loaded with helpful info. Loved this place and would certainly consider going back. Seems like it would be lovely in any season, but was great in summer.
myra2013-07-04T00:00:00ZThe lake house was beautiful and just as advertised. We had a very relaxing 5 day getaway. The location is very private and we didn't see anyone else the entire time (except for boaters on the lake). The house was very well equipped with everything you might need. Rollins Lake can be a bit noisy on the weekends so I would recommend trying to stay during the week if possible. From the house you can also walk down a private trail to the water's edge and use the canoe that is supplied with the house. Highly recommended.
Mike2015-10-14T00:00:00ZWe had such a nice stay at the Lotus Lake House! We wanted a quiet place to spend our wedding anniversary and we found it! We love to cook and found the kitchen full of everything we needed to prepare our meals. We loved the layout of the place and found it to be very cozy. We really enjoyed being off the grid as well, less distraction :) thanks Barie & Tod for creating such a special place for all to enjoy!
Jenifer2015-05-17T00:00:00ZBarrie and Todd were wonderful hosts. They we very prompt and friendly in responding. The house had everything we needed and more. This place is the perfect getaway in a beautiful location. They made it easy to escape!
Tristen2014-05-18T00:00:00ZThe listing was quite accurate. The Lotus Lake House is a beautiful, modern ultra-green dwelling set in the woods with a lovely lake view. It is comfortable and elegant and has a fantastic deck that is at least the size of the house, and was where we spent the majority of our time. The deck has an eating area, sitting areas, a carpet and is the perfect outdoor room.
Pat2016-07-18T00:00:00ZWe really enjoyed this house! The indoor/outdoor space is really nice and it was the perfect amount of space for the two of us and our dogs. It's a short walk down to the lake from the house. We enjoyed feeling a little secluded at the house but still being able to hear the boats/jet skis on the lake. We would definitely recommend Barrie & Tod's place!
Jackie 2015-09-30T00:00:00ZThe glass house is the perfect getaway from civilization, yet you are very close to shops and restaurant nearby. The house has all the necessary amenities to make your stay comfortable, including cooking supplies, toiletries, towels, bath robes, slippers. The house is spacious with modern furniture, but felt very cozy, maybe because you can feel the efforts and considerations given during the construction and maintenance. If you are looking for an unique and comfortable experience in the woods, this is it!
Linya2016-12-04T00:00:00ZArt der Unterkunft
Ganze Unterkunft
Unterkunft für
Grass Valley, Kalifornien 95945, Vereinigte Staaten
It was very last minute to book here, but the host, Olivier responded quick and detail and made the booking faster and easier, which matters to my group a lot. The place is great. It's only 30-40 min away from Lake Tahoe, has enough rooms to fit at least 8 people, quiet neighborhood, with beautiful views. My friends and I are planning to stay here again in winter!! :)
Nicole2015-05-27T00:00:00ZOliver made our stay easy. The neighborhood is very secluded. The wedding we attended was next door, but you could not see or hear anything from either house. The house is very nice and comfortable. We would definitely love to return and explore the area.
Brenda2015-09-16T00:00:00ZAgree with another guest that this place is ideal for making short day trips to ski resorts and Tahoe/Reno, while allowing you to get a jump on the traffic heading back to the Bay Area. House is secluded, but easy to get to from I-80. Plenty of space to enjoy a family meal or enjoy other activities. Also plenty of room to lay out your own sleeping bags for children if you brought them. Major appliances in good shape. Did not have time to use jacuzzi tub, but that looked clean. Lots of movies/books/games to keep you entertained. Would definitely come back!
Rita2017-02-24T00:00:00ZGreat place! Prompt responses from Oliver when selecting the place, very helpful notes throughout. Everything was smooth and easy despite arriving at night and the place was bigger than expected--lots of corners and rooms for people to sleep.
Peter2016-03-28T00:00:00ZPlace is fantastic ! Description is on point ! The house is the perfect mountain retreat , close to the lakes and only 40 mins from Nevada city. House is huge ! Lots and lots of room ! Very clean and classy - Recommend to everyone!
Olivia2015-06-08T00:00:00ZGreat house, quiet environment. We enjoy the stay at this wonderful place.
Chia-Hui2016-12-19T00:00:00ZGreat location and beautiful house. Highly recommended. Private setting in forest and you feel away from everyone. Nice bedrooms, beautiful deck, great common areas. Much recommended.
Ben2015-07-06T00:00:00ZOlivier's place is spacious, clean and well equipped. The beds were comfortable and the silent of the woods ensures a great night's sleep. Our kids enjoyed the snow on a small fraction of the 9 acres of land surround the property. It is a very private and quiet Tahoe retreat. The location is also ideal if you want to beat the Tahoe crowd back to the Bay Area!
Cindy2017-01-16T00:00:00ZArt der Unterkunft
Ganze Unterkunft
Unterkunft für
Alta, Kalifornien 95701, Vereinigte Staaten
Mountain Retreat Guest Suite var en perle, intet mindre. Det vakre, arkitekttegnede ligger stille til i en skråning med store nåletrær, som siler lyset. Rommet har egen inngang og adgang til en deilig, østvendt terrasse. Et oppbygd lite vannfall, lager beroligende lyd som luller en i søvn om kvelden og fungerer som fuglebad for småfuglene. Rommet er smakfullt innredet, sengen er romslig og behagelig og utsikten til soloppgangen mellom trærne var formidabel. Badet var utstyrt med en romslig og komfortabel dusj, deilige håndklær og lokalt produserte såpe- og shampoo produkter av god kvalitet. Rommet hadde også et lite hybelkjøkken der man kunne lage seg litt mat, koke kaffe eller te. Dessuten var det et romslig kjøleskap til det en måtte ha med seg av matvarer. Mate jeg fikk servert var både delikat og velsmakende, og stort sett økologisk. Vertskapet, et eldre, nylig pensjonert ektepar var usedvanlig hyggelige. De var behjelpelig med å hente og bringe meg, og jeg fikk også sitte på med dem til "byen" - det er to å velge mellom: Nevada City og Grass Valley - begge to er så visst besøket verdt, selvom den første er eldst og har mest å vise til av gamle hus og gullgraver-fortid-minner. Det kryr av deilige spisesteder og over alt hvor jeg var, var det "all ecologic", "natural", "grasfed meat" og tilsvarende var det også i de matbutikkene jeg var innom. Jeg var på reise i USA for å promotere en bok jeg nylig har gitt ut, og ettersom vertskapet også tilbyr å arrangere events, takket jeg ja til å la Susan hjelpe meg å arrangere "tea with Grandma Gjertrud" for bokinteresserte i området. Det ble meget vellykket og jeg fikk knyttet kontakter med en rekke likesinnede, noe jeg regner med å kunne følge opp videre når jeg kommer tilbake. For dette er definitivt et sted man kommer tilbake til. Sånn er det bare.
Gunnhild2015-10-09T00:00:00ZSusan and Bob were warm and friendly hosts. The place was beautiful, surrounded by trees and yet close to Nevada City. There were unique and nice touches like a welcome basket and card. We enjoyed our time here.
Feng2015-09-09T00:00:00Z5 stars for my experience at Banner Mountain Retreat! I so enjoyed my stay in the beautiful home of Susan and Bob, along with their sweet dog, Bella. It was my birthday, and I wanted to be nurtured by nature, and in loving company. It met and exceeded those wishes:) It is one of the things that I love about AirBnB in peoples' homes. You have the beautiful locations, cozy rooms, and the heartfelt welcome of the hosts. And it is such a valuable bonus to have the concierge-style recommendations to checking out the best places to eat, shop and visit in the area if that is something you might want to do. But Susan and Bob's place is so beautiful, warm and cozy, you might not want to go anywhere! Such a wonderful place just to BE! Can't say enough...Susan and Bob lovingly prepared delicious food to share with the guests. My room was private, cozy, facing gorgeous trees and I had all the privacy I wanted, and also the best company when I wanted to be social. The hot tub and gorgeous nature bathed my soul and the my heart was planted there. I am deeply grateful, and I am already looking for the next time I can return:) Highly recommended to anyone who loves beauty, nature, great food and good people!
Kat2016-02-09T00:00:00ZSusan Davis's Banner Mountain Retreat is in a forested area of the Sierra Nevada foothills about 10 minutes above the charming town of Nevada City and nearby Grass Valley. It is not located in what a city-dweller would consider a neighborhood—it's more rural than that. But other properties and a residence or two are near enough that they are visible. The property has a large deck, and in back a hot tub that you can use at any time of day or night. There is also small stream and pond that is beloved by birds and small animals. The parking space is ample. The Davises have a friendly, well-mannered, beautiful dog, Bella, who is eager for you to join her in play if you want to take her up on it. Yet she is well-mannered and not invasive. Susan did everything you could ever want from a hostess to be welcoming, and to make the stay enjoyable. Breakfast is served and is homemade right down to pastries and good coffee. In advance of arriving she provided detailed directions including how to avoid unnecessary traffic stops. The room had gifts of locally made chocolate, jams, and honey, a coffeemaker, fridge with San Pellegrino, and a microwave. Locally-milled, naturally-scented soaps were also provided. The bed was comfortable. Susan provided guidance to local wineries, entertainment venues, craft shops and good cafes and restaurants. She is there when you need her, but stays out of your hair and let's you come and go as you care to. You have privacy and can do as you like. This place is a real find. It provides great value at the price. You can really rest here if that is your choice, or hike, find great locally roasted coffee, go into both Nevada City and Grass Valley. There are also mountain drives nearby. This area was prominent during the Gold Rush and tours of a local and important mine are available. This area teams with artists, healers, herbalists, and spiritual retreats. It also has young families and also everyday people who like the air, forests and streams.
Kenneth W2015-11-04T00:00:00ZI had a wonderful time at Banner Mountain Retreat. The home is very cozy and nestled in a very sweet location. Susan and Bob are great hosts, by cooking great meals and arranging beautiful walks they both made me feel ruth at home. My room was private, quite and quite comfortable. The hot tub was delightful as well. I fell in love with their dog Bella, who just loves to play and snuggle!
Todd2015-12-17T00:00:00ZWhat a Beautiful setting. Peaceful. We loved the garden. Nevada City is such a lovely place and close to the Bay Area. An easy drive on Saturday Morning. Thanks for hosting us AND making sure to include local treats for breakfast. Thanks for making us feel welcome.
Jacqueline2016-06-24T00:00:00ZWonderful people and a delightful stay. The room is great. I slept well on the featherbed. The house and location are lovely and the hot tub is icing on the cake. Yummy breakfast!
Agnes2016-01-20T00:00:00ZWhat a lovely stay with Susan and Bob. Their beautiful home reflects their interests in the arts and their community. Wonderful breakfast conversations around delicious food and dining. We learned so much about the beautiful Nevada City community and the charming people that reside there. Truly a delightful stay one will remember for a long time.
deb2016-10-30T00:00:00ZArt der Unterkunft
Unterkunft für
Nevada City, Kalifornien 95959, Vereinigte Staaten
We really enjoyed our stay at your home, the downstairs area was very private, clean and comfortable. We also appreciated your recommendations for restaurants and talking to you both in the morning! We'd love to come back during another season so we can enjoy the welcoming porch!
Amanda2017-03-01T00:00:00ZWe had a wonderful stay at Ildiko's beautiful, mountain home. The suite was both roomy and comfortable. The views overlooking the valley and mountain beyond was awesome. Truly a memorable trip. Thank you!
Cheryl2015-02-17T00:00:00ZWhile visiting in Nevada City area, We found Ildiko listing on airbnb and book the room for 4 days. What a amazing place to stay. Very tranquil and relaxing and such a nice place. Ildiko and Ken were such great host too and always checking in to make sure we were okay and made sure we felt comfortable during our stay. You couldn't ask for a better airbnb experience. I would highly recommend staying here while visiting the Grass Valley, Nevada City areas.
Ray2015-10-25T00:00:00ZWe enjoyed staying at Ildi and Ken's downstairs suite with a beautiful view overlooking the forested mountains. They graciously welcomed us in to their gorgeous house and we quickly bonded with them over woodworking and world travels. The downstairs suite was the perfect place to relax after our days of traveling between Nevada City, Grass Valley, and the surrounding recreation areas for a weekend. We couldn't imagine a better and more peaceful retreat! Ildi was eager to meet any need we had. Our last day, she invited us up for homemade crepes and they were delicious. Thanks for being great hosts!
Brad & Kalie2015-01-31T00:00:00ZArt der Unterkunft
Unterkunft für
Grass Valley, Kalifornien 95945, Vereinigte Staaten
The hosts had wine and chocolates out for us. Also kitchen was well stocked with basics. Craig and Caroline are very nice people.
Joseph2016-10-06T00:00:00ZWe had a great experience at Camp Run A Muck. Two families -- four adults and four children -- stayed there over a weekend. Craig was the perfect host. He is very helpful, welcoming and communicative, and the house is clean, comfortable, well stocked and easily accommodated our group. The short walk down to the water for swimming was great. The kids loved the video games (maybe a little too much!), and we all enjoyed cocktails, meals and morning coffee out on the deck. Highly recommended!
Ingrid2016-09-01T00:00:00ZWe absolutely loved our stay at Camp Run a Muck! Beautifully furnished on the inside with the perfect deck outside. One minute walk down to the lake and the wine and chocolates waiting for us were a great treat! Thank you Craig and Caroline!
Kevin2014-06-30T00:00:00ZCraig is a super nice host and always willing to answer all your questions. We had a great time at his place! The house was cozy and very well equipped with everything we needed for a relaxing vacation. Also the location was great with a beautiful lake nearby. I can recommend staying at Craig's and Caroline's lovely house!
Laura2014-12-30T00:00:00ZThis is an incredible place to stay. Scotts Flat is a perfect escape: from people, heat, work, whatever you need to escape from. The cabin is spacious, very well stocked, and extremely comfortable, although, to be honest, we spent most of our time in on the perfect, shaded deck. Craig was an excellent host. Although I did not get a chance to meet him, he made sure all my group's needs were accommodated and was extremely prompt with any questions I had.
Oliver2015-08-17T00:00:00ZWhat a fantastic experience my friends and I had at Camp Run A Muck. Tucked in the woods of Nevada City, surrounded by the trees and Lake. The cabin had such a great charm and feel to it. Having stayed at many rentals in the past, I must say, Craig + Caroline thought of the little things for guests that many other places don't..for instance, the labeling of just about everything! You would never think it to be that big of a deal, until it's done for you. Every light switch and little nuance of the house has a little tip left next to it. They have certainly thought of EVERYTHING a guest might need...from the labels down to the brush for pine needles on the deck to the fundamental things left in the kitchen (ie. sugar, honey, oil etc). C + C were super friendly and easy to work with. What a great place that me and my 8 other friends and old dog had a place to spend away from the city. We sat on the deck every night playing cards and enjoying the nature. Every room was homely and comfortable. Will def come back again! thanks, Craig + Caroline!
Jennie2015-08-31T00:00:00ZCamp run-a-muck was a lovely, unique, and charming cabin that provides nearly everything you'd need or want! Craig the host, was very welcoming and has honestly thought of everything for the camp. Motion lights in the halls for night time bathroom trips, automatic settings on outdoor lights, plenty of dishware, even flashlights on bed sides! The neighborhood was lovely and the lake was stunning. Craig was very available, thorough, and friendly. We'd stay here again without a doubt.
Lindsey2016-07-15T00:00:00ZGreat and quiet location! Craig was very quick to respond to e-mails, helpful with inquiries, and made the arrival process smooth and welcoming. Right by the serene Scotts Flat Reservoir, nestled in the trees, and an easy jump over the hill to Nevada City and easy reach to the South Yuba. Thanks bunches!!
John2016-09-27T00:00:00ZArt der Unterkunft
Ganze Unterkunft
Unterkunft für
Nevada City, Kalifornien 95959, Vereinigte Staaten

subset: commoncrawl


text:
Magnetic Resonance Imaging (MRI) - Spine
Magnetic resonance imaging (MRI) of the spine uses radio waves, a magnetic field and a computer to produce detailed pictures of the spine and surrounding tissues that are clearer and more detailed than other imaging methods. The exam does not use ionizing radiation and may require an injection of a contrast material called gadolinium, which is less likely to cause an allergic reaction than iodinated contrast material.
Tell your doctor about any health problems, recent surgeries or allergies and whether there's a possibility you are pregnant. The magnetic field is not harmful, but it may cause some medical devices to malfunction. Most orthopedic implants pose no risk, but you should always tell the technologist if you have any devices or metal in your body. Guidelines about eating and drinking before your exam vary between facilities. Unless you are told otherwise, take your regular medications as usual. Leave jewelry at home and wear loose, comfortable clothing. You may be asked to wear a gown. If you have claustrophobia or anxiety, you may want to ask your doctor for a mild sedative prior to the exam.
- What is MRI of the Spine?
- What are some common uses of the procedure?
- How should I prepare?
- What does the equipment look like?
- How does the procedure work?
- How is the procedure performed?
- What will I experience during and after the procedure?
- Who interprets the results and how do I get them?
- What are the benefits vs. risks?
- What are the limitations of MRI of the Spine?
What is MRI of the Spine?
Magnetic resonance imaging (MRI) is a noninvasive medical test that physicians use to diagnose and treat medical conditions.
MRI uses a powerful magnetic field, radio frequency pulses and a computer to produce detailed pictures of organs, soft tissues, bone and virtually all other internal body structures. MRI does not use ionizing radiation (x-rays).
Detailed MR images allow physicians to evaluate various parts of the body and determine the presence of certain diseases. The images can then be examined on a computer monitor, transmitted electronically, printed or copied to a CD.
An MRI examination of the spine shows the anatomy of the vertebrae that make up the spine, ligaments that hold the vertebrae together, as well as the disks, spinal cord and the spaces between the vertebrae through which nerves pass.
Currently, MRI is the most sensitive imaging test of the spine in routine clinical practice.
What are some common uses of the procedure?
MR imaging is performed to:
- assess spinal anatomy and alignment.
- detect congenital anomalies of vertebrae or the spinal cord.
- detect bone, disc, ligament or spinal cord injury after spine trauma.
- assess intervertebral disk disease (degenerated, bulging or herniated) and intervertebral joint disease, both frequent causes of severe lower back pain and sciatica (back pain radiating into lower leg).
- explore other possible causes of back pain (compression fracture or bone swelling, such as edema).
- assess compression of spinal cord and nerves.
- assess inflammation of the spinal cord or nerves.
- assess infection involving the spine, disks and spinal contents including spinal cord or its coverings (meninges).
- assess tumors that arise from or have spread to the vertebrae, spinal cord, nerves or the surrounding soft tissues.
- help plan spinal surgical procedures, such as decompression of a pinched nerve, spinal fusion, or the injection of steroids to relieve spinal pain. Such injections are usually performed under CT guidance.
- monitor changes in the spine after an operation, such as scarring or infection.
How should I prepare?
You may be asked to wear a gown during the exam or you may be allowed to wear your own clothing if it is loose-fitting and has no metal fasteners.
Guidelines about eating and drinking before an MRI exam vary with the specific exam and also with the imaging facility. Unless you are told otherwise, you may follow your regular daily routine and take food and medications as usual.
Some MRI examinations may require you to receive an injection of contrast material into the bloodstream. The radiologist, technologist or a nurse may ask if you have allergies of any kind, such as an allergy to iodine or x-ray contrast material, drugs, food, or the environment, or if you have asthma. The contrast material most commonly used for an MRI exam contains a metal called gadolinium. Gadolinium can be used in patients with iodine contrast allergy, but may require pre-medication. It is far less common for a patient to have an allergy to a gadolinium-based contrast agent used for MRI than the iodine-containing contrast for CT. However, even if it is known that the patient has an allergy to the gadolinium contrast, it may still be possible to use it after appropriate pre-medication. Patient consent will be requested in this instance. For more information on adverse reactions to gadolinium-based contrast agents, please consult the ACR Manual on Contrast Media.
You should also let the radiologist know if you have any serious health problems, or if you have had any recent surgeries. Some conditions, such as severe kidney disease, may prevent you from being given gadolinium contrast for an MRI. If you have a history of kidney disease or liver transplant, it will be necessary to perform a blood test to determine whether the kidneys are functioning adequately.
Women should always inform their physician or technologist if there is any possibility that they are pregnant. MRI has been used for scanning patients since the 1980s with no reports of any ill effects on pregnant women or their unborn babies. However, because the unborn baby will be in a strong magnetic field, pregnant women should not have this exam in the first trimester of pregnancy unless the potential benefit from the MRI exam is assumed to outweigh the potential risks. Pregnant women should not receive injections of gadolinium contrast material except when absolutely necessary for medical treatment. See the Safety page for more information about pregnancy and MRI.
If you have claustrophobia (fear of enclosed spaces) or anxiety, you may want to ask your physician for a prescription for a mild sedative prior to your scheduled examination.
Infants and young children usually require sedation or anesthesia to complete an MRI exam without moving. Whether a child requires sedation depends on the child's age and the type of exam. Moderate and conscious sedation can be provided at many facilities. A physician or nurse specializing in sedation or anesthesia for children should be available during the exam for your child's safety. You will be given special instructions for how to prepare your child for the sedation or anesthesia.
Jewelry and other accessories should be left at home if possible, or removed prior to the MRI scan. Because they can interfere with the magnetic field of the MRI unit, metal and electronic items are not allowed in the exam room. These items include:
- jewelry, watches, credit cards and hearing aids, all of which can be damaged
- pins, hairpins, metal zippers and similar metallic items, which can distort MRI images
- removable dental work
- pens, pocket knives and eyeglasses
- body piercings
In most cases, an MRI exam is safe for patients with metal implants, except for a few types. People with the following implants cannot be scanned and should not enter the MRI scanning area:
- cochlear (ear) implant
- some types of clips used for brain aneurysms
- some types of metal coils placed within blood vessels
- nearly all cardiac defibrillators and pacemakers
You should tell the technologist if you have medical or electronic devices in your body. These objects may interfere with the exam or potentially pose a risk, depending on their nature and the strength of the MRI magnet. Many implanted devices will have a pamphlet explaining the MRI risks for that particular device. If you have the pamphlet, it is useful to bring that to the attention of the technologist or scheduler before the exam. Some implanted devices require a short period of time after placement (usually six weeks) before being safe for MRI examinations. Examples include but are not limited to:
- artificial heart valves
- implanted drug infusion ports
- artificial limbs or metallic joint prostheses
- implanted nerve stimulators
- metal pins, screws, plates, stents or surgical staples
If there is any question of their presence, an x-ray may be taken to detect and identify any metal objects. In general, metal objects used in orthopedic surgery pose no risk during MRI. However, a recently placed artificial joint may require the use of another imaging procedure.
Patients who might have metal objects in certain parts of their bodies may also require an x-ray prior to an MRI. You should notify the technologist or radiologist of any shrapnel, bullets, or other pieces of metal which may be present in your body due to prior accidents. Foreign bodies near and especially lodged in the eyes are particularly important. Dyes used in tattoos may contain iron and could heat up during MRI, but this is rarely a problem. Tooth fillings and braces usually are not affected by the magnetic field, but they may distort images of the facial area or brain, so the radiologist should be aware of them.
Parents or family members who accompany patients into the scanning room also need to remove metal objects and notify the technologist of any medical or electronic devices they may have.
What does the equipment look like?
The traditional MRI unit is a large cylinder-shaped tube surrounded by a circular magnet. You will lie on a moveable examination table that slides into the center of the magnet.
Some MRI units, called short-bore systems, are designed so that the magnet does not completely surround you. Some newer MRI machines have a larger diameter bore which can be more comfortable for larger size patients or patients with claustrophobia. Other MRI machines are open on the sides (open MRI). Open units are especially helpful for examining larger patients or those with claustrophobia. Newer open MRI units provide very high quality images for many types of exams; however, older open MRI units may not provide this same image quality. Certain types of exams cannot be performed using open MRI. For more information, consult your radiologist.
The computer workstation that processes the imaging information is located in a separate room from the scanner.
How does the procedure work?
Unlike conventional x-ray examinations and computed tomography (CT) scans, MRI does not utilize ionizing radiation. Instead, radio waves redirect alignment of hydrogen atoms that naturally exist within the body while you are in the scanner without causing any chemical changes in the tissues. As the hydrogen atoms return to their usual alignment, they emit energy that varies according to the type of body tissue from which they come. The MR scanner captures this energy and creates a picture of the tissues scanned based on this information.
The magnetic field is produced by passing an electric current through wire coils in most MRI units. Other coils, located in the machine and in some cases, placed around the part of the body being imaged, send and receive radio waves, producing signals that are detected by the coils. The electric current does not come in contact with the patient.
A computer then processes the signals and generates a series of images, each of which shows a thin slice of the body. The images can then be studied from different angles by the interpreting radiologist.
Frequently, the differentiation of abnormal (diseased) tissue from normal tissues is better with MRI than with other imaging modalities such as x-ray, CT and ultrasound.
How is the procedure performed?
MRI examinations may be performed on outpatients or inpatients.
You will be positioned on the moveable examination table. Straps and bolsters may be used to help you stay still and maintain the correct position during imaging.
Devices that contain coils capable of sending and receiving radio waves may be placed around or adjacent to the area of the body being studied.
Depending on the location of symptoms, only part of the spine may be imaged. For example, the cervical (neck) portion, the thoracic (chest) spine or the lumbar (lower) spine. Intravenously injected contrast material may be used when looking for infection, tumors or recurrent disk issues after a surgery.
If a contrast material will be used in the MRI exam, a physician, nurse or technologist will insert an intravenous (IV) catheter, also known as an IV line, into a vein in your hand or arm. A saline solution may be used to inject the contrast material. The solution will drip through the IV to prevent blockage of the IV catheter until the contrast material is injected.
You will be placed into the magnet of the MRI unit and the radiologist and technologist will perform the examination while working at a computer outside of the room.
When the examination is complete, you may be asked to wait until the technologist or radiologist checks the images in case additional images are needed.
Your intravenous line will be removed.
MRI exams generally include multiple runs (sequences), some of which may last several minutes.
The entire examination is usually completed within 30 to 60 minutes, depending on whether the entire length of the spine is scanned or only part of the spine is scanned. If contrast material is used, more images are needed after the injection which adds an additional 15 to 20 minutes to the total scan time.
What will I experience during and after the procedure?
Most MRI exams are painless. However, some patients find it uncomfortable to remain still during MR imaging. Others experience a sense of being closed-in (claustrophobia). Therefore, sedation can be arranged for those patients who anticipate anxiety, but fewer than one in 20 require medication.
It is normal for the area of your body being imaged to feel slightly warm, but if it bothers you, notify the radiologist or technologist. It is important that you remain perfectly still while the images are being obtained, which is typically only a few seconds to a few minutes at a time. You will know when images are being recorded because you will hear and feel loud tapping or thumping sounds when the coils that generate the radiofrequency pulses are activated. Some centers provide earplugs, while others use headphones to reduce the intensity of the sounds made by the MRI machine. You will be able to relax between imaging sequences, but will be asked to maintain your position without movement as much as possible.
You will usually be alone in the exam room during the MRI procedure. However, the technologist will be able to see, hear and speak with you at all times using a two-way intercom. Many MRI centers allow a friend or parent to stay in the room as long as they are also screened for safety in the magnetic environment.
Children will be given appropriately sized earplugs or headphones during the exam. MRI scanners are air-conditioned and well-lit. Music may be played through the headphones to help you pass the time.
In some cases, intravenous injection of contrast material may be performed. The intravenous needle may cause you some discomfort when it is inserted and you may experience some bruising. There is also a very small chance of irritation of your skin at the site of the IV tube insertion. Some patients may sense a temporary metallic taste in their mouth after the contrast injection.
If you have not been sedated, no recovery period is necessary. You may resume your usual activities and normal diet immediately after the exam. On very rare occasions, a few patients experience side effects from the contrast material, including nausea and local pain. Similarly, patients are very rarely allergic to the contrast material and experience hives, itchy eyes or other reactions. If you experience allergic symptoms, notify the technologist. A radiologist or other physician will be available for immediate assistance.
Who interprets the results and how do I get them?
A radiologist, a physician specifically trained to supervise and interpret radiology examinations, will analyze the images and send a signed report to your primary care or referring physician, who will share the results with you.
Follow-up examinations may be necessary, and your doctor will explain the exact reason why another exam is requested. Sometimes a follow-up exam is done because a potential abnormality needs further evaluation with additional views or a special imaging technique. A follow-up examination may also be necessary so that any change in a known abnormality can be monitored over time. Follow-up examinations are sometimes the best way to see if treatment is working or if a finding is stable or changed over time.
What are the benefits vs. risks?
- MRI is a noninvasive imaging technique that does not involve exposure to ionizing radiation.
- MR images of the spine are clearer and more detailed than images obtained with other imaging methods. MRI can show abnormalities, injuries and diseases in the spinal region that may not be seen with other imaging methods. MRI is the best available modality to visualize spinal cord and nerves.
- MRI enables the discovery of abnormalities that might be obscured by bone with other imaging methods.
- The contrast material used in MRI exams is less likely to produce an allergic reaction than the iodine-based contrast materials used for conventional x-rays and CT scanning.
- MRI is very useful for evaluating spinal injuries. It is especially helpful for diagnosing or ruling out acute compression of the spinal cord when the clinical examination shows muscle weakness or paralysis. MRI is the best modality available for evaluation of ligament injuries.
- MRI is able to detect subtle changes in the vertebral column that may be an early stage of infection or tumor. The procedure is more sensitive than CT scanning for evaluating tumors, abscesses and other soft tissue masses near the spinal cord.
- MRI is the preferred technique in evaluating for potential complications of surgery, including bleeding, scarring, infection and re-appearance of a herniated disk.
- The MRI examination poses almost no risk to the average patient when appropriate safety guidelines are followed.
- If sedation is used, there are risks of excessive sedation. However, the technologist or nurse monitors your vital signs to minimize this risk.
- Although the strong magnetic field is not harmful in itself, implanted medical devices that contain metal may malfunction or cause problems during an MRI exam.
- Nephrogenic systemic fibrosis is currently a recognized, but rare, complication of MRI believed to be caused by the injection of high doses of gadolinium-based contrast material in patients with very poor kidney function. Careful assessment of kidney function before considering a contrast injection minimizes the risk of this very rare complication.
- There is a very slight risk of an allergic reaction if contrast material is injected. Such reactions usually are mild and easily controlled by medication. If you experience allergic symptoms, a radiologist or other physician will be available for immediate assistance.
- Manufacturers of intravenous contrast indicate mothers should not breastfeed their babies for 24-48 hours after contrast medium is given. However, both the American College of Radiology (ACR) and the European Society of Urogenital Radiology note that the available data suggest that it is safe to continue breastfeeding after receiving intravenous contrast. For further information please consult the ACR Manual on Contrast Media and its references.
What are the limitations of MRI of the Spine?
High-quality images are assured only if you are able to remain perfectly still and follow breath-holding instructions while the images are being recorded. If you are anxious, confused or in severe pain, you may find it difficult to lie still during imaging.
A person who is very large may not fit into the opening of certain types of MRI machines.
The presence of an implant or other metallic object sometimes makes it difficult to obtain clear images. Patient movement can have the same effect.
A very irregular heartbeat may affect the quality of images obtained using techniques that time the imaging based on the electrical activity of the heart, such as electrocardiography (EKG).
MRI generally is not recommended for patients who have been acutely injured; however, this decision is based on clinical judgment. This is because traction devices and many types of life support equipment may distort the MR images and as a result, must be kept away from the area to be imaged. Furthermore, the examination takes longer than other imaging modalities (typically x-ray and CT) and the results may not be immediately available, as is often necessary in trauma situations.
Although there is no reason to believe that magnetic resonance imaging harms the fetus, pregnant women usually are advised not to have an MRI exam during the first trimester unless medically necessary.
MRI typically costs more and may take more time to perform than other imaging modalities.
In some patients, vertebral fractures may be better detected by CT scan.
This page was reviewed on March 01, 2017


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Niagara Falls Newspaper Owner Simply Does Not Care For Snarling Feminism Like 'Snow White'
Do you frequently find yourself longing for a simpler, quieter time? A time with less argument, less dissent? A time where pesky things like "women" were not all walking around, being humans?
Niagara Falls Reporter editor Frank Parlato is! He's...


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Holdernes Early OriginsThe surname Holdernes was first found in East Riding of Yorkshire at Skipsea. "The manor is one of those which have continued members of the seigniory of Holderness to the present day. In the 12th of Edward III., the king granted a market to the place, to be held on Thursday in every week, and two fairs to be held annually, one on All Saints' day, and the other on the day of the translation of St. Thomas the Martyr." [1]CITATION[CLOSE] Lewis, Samuel, A Topographical Dictionary of England. Institute of Historical Research, 1848, Print. Holdernes Spelling VariationsHoldernes Spelling VariationsHoldernes has been spelled many different ways, including Before English spelling became standardized over the last few hundred years, spelling variations in names were a common occurrence. As the English language changed in the Middle Ages, absorbing pieces of Latin and French, as well as other languages, the spelling of people's names also changed considerably, even over a single lifetime. Holderness, Holdernesse, Houlderness and others. Holdernes Early HistoryHoldernes Early HistoryThis web page shows only a small excerpt of our Holdernes research. Another 151 words (11 lines of text) are included under the topic Early Holdernes History in all our PDF Extended History products and printed products wherever possible. Holdernes Early Notables (pre 1700)Holdernes Early Notables (pre 1700)More information is included under the topic Early Holdernes Notables in all our PDF Extended History products and printed products wherever possible. The Great MigrationThe Great MigrationIn an attempt to escape the chaos experienced in England, many English families boarded overcrowded and diseased ships sailing for the shores of North America and other British colonies. Those families hardy enough, and lucky enough, to make the passage intact were rewarded with land and a social environment less prone to religious and political persecution. Many of these families became important contributors to the young colonies in which they settled. Early immigration and passenger lists have documented some of the first Holderness to arrive on North American shores: Henry Holdernesse arrived in Philadelphia in 1807; Edward and William Holderness settled in Philadelphia in 1820. Holdernes Family Crest ProductsHoldernes Family Crest ProductsSee AlsoSee AlsoCitationsCitations
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The Holdernes Family Crest was acquired from the Houseofnames.com archives. The Holdernes Family Crest was drawn according to heraldic standards based on published blazons. We generally include the oldest published family crest once associated with each surname. This page was last modified on 12 February 2016 at 10:13. Sign Up
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Cereals Leaf spots on wheat are still coming into the lab with Septoria leaf spot (Stagonospora) now becoming more common. Septoria was detected on 5 wheat samples (North Parkland, Red River), tan spot was detected on 4 of those same samples and one also had spot blotch present as a third disease in the same sample (Red River). Humidity and wet weather favour development of fungus leaf spots. One sample of wheat was diagnosed with root rot from a combination of Pythium and Fusarium (Valleys North). Barley yellow dwarf virus was diagnosed on one wheat sample (South Parkland). For wheat streak mosaic virus, this week brought five samples with the disease (Southwest, Pembina, South Parkland).
Again this week, oats with bacterial blight were received (Central Plains). One sample of oats showing symptoms consistent with exposure to a contact herbicide was received (South Interlake).
Oats – bacterial leaf blight can have small spots on the leaf blade, blighting back from the leaf tip or long necrotic streaks
Oats – contact herbicide can cause yellow blotching and necrotic spotting of leaves.
One sample of barley was diagnosed with net blotch (Southwest). The spotting initially appeared to be spot blotch but lab tests indicated presence of the net blotch fungus. Net blotch has two subspecies of the fungus. One produces a netted type spot and one produces a discrete spot type very similar to spot blotch. One sample of barley was found to be affected by root rot caused by Rhizoctonia and Fusarium (Southwest). One sample of barley had symptoms consistent with a nutrient deficiency (Southwest).
Barley net blotch – the spot form of net blotch is difficult to distinguish from spot blotch without lab testing.
Oil Seeds One sample of canola leaves with severe necrotic leaf mottle from downy mildew was received (Red River). Humidity in the canopy is highly favourable for downy mildew and when severely affected, the leaves can tatter easily. On one leaf of that same sample, a small Phoma leaf spot (blackleg) was detected. One sample of canola had an unusual chlorotic leaf mottle suspected of being caused by abiotic factors since no pathogens were detected (Red River). One sample of canola with severe leaf burn consistent with contact herbicide was received (Pembina). One sample of canola showing symptoms of loss of chlorophyll consistent with exposure to a group 27 herbicide was received along with peas and alfalfa showing similar symptoms (South Parkland). One sample of canola with symptoms of group 4 herbicide injury was received (Eastman). One sample of canola with symptoms consistent with a group 2 herbicide exposure was received (South Parkland).
Canola – downy mildew (top side of leaf) causes a necrotic mottle of leaves.
Canola - downy mildew (underside of leaves)
Canola – group 27 herbicide causes a loss of chlorophyll which can cause the affected tissue to appear almost bleached.
Legume Crops One sample of peas was diagnosed with root rot caused by Fusarium solani (Southwest).
Forage Legumes One sample of alfalfa had symptoms consistent with a potassium deficiency (Central Plains).
Fruit One sample of saskatoon showed a marginal leaf browning consistent with a vascular impairment and also had a leaf spot caused by Phyllosticta (Pembina).
Vegetables/Potatoes/Herbs One sample of tomato showing symptoms of stress, possibly nutritional in nature, was received (Central Plains).
Trees and Shrubs One sample of oak was diagnosed with anthracnose (Eastman) and was also found to have a leaf spot caused by Monochaetia. Anthracnose of oak is an interesting disease since susceptibility can vary from tree to tree and within a population, some can be severely affected while others show minor symptoms. Two samples of elm with branch dieback were found to be affected by a canker disease (Winnipeg). One sample of ornamental plum was found to have leaf blighting caused by two fungi, Pestalotia and Phyllosticta (Red River). One sample of mountain ash showed symptoms of a marginal necrosis of leaflets indicating a possible vascular problem as well as development of leaf spot caused by Phyllosticta (Red River). Vascular impairments in woody plants can be caused in roots, main stems or individual branches and can cause symptoms far beyond the place in the tree/shrub where the problem is located. If the problem is disease related, the disease can be undetectable in samples submitted to the lab if they are distal to the point of infection. A sample consisting of various tree species showing symptoms of glyphosate translocation injury was submitted (Central Plains). One sample of ornamental apple showing symptoms of apple scab was received (Valleys North). One sample of caragana with a curling and cupping of leaflets consistent with a growth regulator herbicide injury was received (Valleys North).
Mountain ash – browning of leaf margins is often an indicator of a vascular problem in trees and shrubs. Symptoms could be related to root problems or infection of the vascular system by fungi or bacteria.
One sample of spruce with stress symptoms and no evidence of disease was submitted (Pembina). Again this week we received a spruce sample showing twig damage from the ragged spruce gall adelgid along with the fungus Stigmina on needles (Winnipeg).
The Diagnostic Lab Report is prepared by Mardi Desjardins, Crop Diagnostic Centre, Manitoba Agriculture, Food and Rural Initiatives, 201-545 University Crescent, Winnipeg, Manitoba R3T 5S6. Phone: 204-945-7707 Fax: 204-945-4327.


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Elizabeth Greenwood
Playing Dead: A Journey Through the World of Death Fraud
Monday, November 7 at 7:00pm
Is the election making you want to disappear? Need a few tips for how to fake your death in case things don't go your way? Join Elizabeth Greenwood, author of PLAYING DEAD: A Journey Through the World of Death Fraud, and journalist Evan Ratliff on Election Eve to discuss PLAYING DEAD and all things vanishing and vaporizing.
Is it still possible to fake your own death in the twenty-first century? With six figures of student loan debt, Elizabeth Greenwood was tempted to find out.
So begins her foray into the world of death fraud, where for $30,000 a consultant can make you disappear—but your suspicious insurance company might hire a private detective to dig up your coffin and find it filled with rocks.
Greenwood tracks down a British man who staged a kayaking accident and then returned to live in his own house while all his neighbors thought he was dead. She takes a call from Michael Jackson (no, he's not dead—or so her new acquaintances would have her believe), stalks message boards for people plotting pseudocide, and buys her own death certificate in the Philippines. Along the way, she learns that love is a much less common motive than money, and that making your death look like a drowning virtually guarantees that you'll be caught. (Disappearing while hiking, however, is a way great to go.)
Utterly fascinating and charmingly bizarre, Playing Dead is an empathetic investigation into a universal human fantasy and the men and women desperate enough to give up their lives—and their families—to start again.
** PRAISE for PLAYING DEAD **
"Ms. Greenwood takes us on a romp through the world of the living dead — not zombies, but real folk who for one reason or another decide the best way to go on with life is to fake death. It's a delightful read, and for anyone tantalized by the prospect of disappearing without a trace it might even provide some useful tips —though Greenwood is careful to caution that "pseudocide" is rarely painless."
— Erik Larson, #1 New York Times bestselling author of Dead Wake
"Elizabeth Greenwood is as entertaining and gifted an archeologist of subcultures as she is an able explorer of issues like anonymity, the right to privacy, and how much control people can ever exert over their identities. An energetic and insatiable writer, her generous mind infuses every page of this astonishing book."
— Heidi Julavits, author of The Folded Clock
"An insightful look at the reasoning behind often desperate choices. Wonderfully weird."
— Deborah Blum, New York Times bestselling author of The Poisoner's Handbook
"Ms. Greenwood leaps into an anecdote-filled history of — and rough primer for — erasing yourself. She shrewdly notes that our fascination with vanishing is only heightened by the 'hypervisibility of our age.'… The fun in Greenwood's book — much of it admittedly grim fun — is in learning the details."
— New York Times
"It's highly entertaining — the perfect late-summer read."
—Lenny Letter
"The most literally escapist summer read you could hope for."
—Paris Review
"Belongs to that genre of popular nonfiction best exemplified by Jon Ronson.... It's a form that above all requires a likable, self-deprecating, curious narrator, and Greenwood fits the bill."
Elizabeth Greenwood
grew up in Worcester, Massachusetts. Her writing has appeared in The Believer and the digital editions of The New Yorker, The Atlantic and VICE. She teaches creative nonfiction at Columbia University. Playing Dead is her first book.
Evan Ratliff
is the co-founder and editor in chief of The Atavist Magazine, an eight-time National Magazine Award finalist and two-time Emmy finalist. As a writer, his work also appears in The New Yorker, National Geographic, and Wired. His 2009 Wired story "Vanish" -- about his attempt to disappear and the public's effort to find him -- was a National Magazine Award finalist and featured in The Best American Magazine Writing. He is currently at work on a book for Random House about the man behind the 21st century's largest international criminal cartel, recounted first in his 2016 Atavist Magazine serial "The Mastermind."
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Beschäftigungskonten für Deutschland
We present a proposal for reforming unemployment assistance in Germany through the introduction of unemployment accounts (UAs). Instead of paying taxes that finance the unemployment assistance, employed people make ongoing contributions to their UAs and can make withdrawals from these accounts during periods of unemployment. The aim of this policy proposal is to improve employment incentives without significant changes in the current redistribution scheme. We provide a detailed account of how such a system of UAs can be designed and implemented in Germany. To make the influence of UAs as transparent as possible and to avoid introducing other reforms that may make significant bodies of people worse off, we assume that UAs are integrated within the existing unemployment support system, keeping all institutional rules regarding conditions, duration and size of entitlements as well as interpersonal redistribution unchanged. Copyright 2008 der Autoren Journal compilation 2008, Verein für Socialpolitik und Blackwell Publishing Ltd.
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Volume (Year): 9 (2008)
Issue (Month): 2 (05)
Pages: 139-155
Handle: | RePEc:bla:perwir:v:9:y:2008:i:2:p:139-155 |
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- Martin Feldstein & Daniel Altman, 2007.
"Unemployment Insurance Savings Accounts,"
NBER Chapters,
in: Tax Policy and the Economy, Volume 21, pages 35-64
National Bureau of Economic Research, Inc.
- Martin Feldstein & Daniel Altman, 1998. "Unemployment Insurance Savings Accounts," NBER Working Papers 6860, National Bureau of Economic Research, Inc.
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