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Frank Odorisio, James F. Pietro, and Vince J. Pietro
(402) 397-4505 625 N 144th Ave, Omaha, NE 68154 M-Th 8am-5pm, F-Su Closed
Categories: Dentists
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Dentists Who Treat You Like Family. Family Dental Health in Omaha, NE, has cared for the dental needs of the surrounding community for more than 30 years. Drs. Frank Odorisio, James F. Pietro, and Vince J. Pietro form a team that truly cares about our patients' needs. There are many dentists to choose from, and most of the services they offer are the same. At Family Dental Health, we distinguish ourselves from the pack by being very attentive, thorough, and gentle. It's not so much what we do as how we do it that matters. Our services include: • Routine checkups • Extractions • Crowns and bridges • Fillings • Implants • Dentures • Veneers and dental bonding If you're interested in a sparkling smile, we can provide take-home teeth whitening kits too. We're also a great source for outpatient hospital services for children and adults with special needs. When you come to Family Dental Health for care, we treat each patient, from those who are two years old to those who are 102 years old, with the same patience and respect that we'd give to our own families. Call Family Dental Health today to schedule your next appointment!
Nearby Related BusinessesRockbrook Family Dentistry DDS
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Six Ways to Promote Positivity and Encouragement in the Hearts of Your Children
I was recently confessing to a friend how easy it is for me to find myself constantly bringing down my kids - whether in their character, studies, family relationships, cleanliness - without even realizing many of the wonderful things they did throughout the day. While equipping and correcting are necessary parts of parenting, so is encouragement and edification. I have seen time and time again that building my children UP is far more valuable and life changing than being a nagging voice and continual reminder of things they could do better.. But HOW???
Below we've listed out six ways to promote positivity and encouragement in the hearts of your children that we've found useful in our own homes, as well as three FREE SCRIPTURE PRINTABLES!
Jar full of Rocks- This is a fun way to encourage family team work as everyone is on the same team trying to fill the jar to the top. We praise and acknowledge good behavior, diligence, kindness, answering questions correctly for school, chores done early, etc. and allow the kids to drop a rock (or two!) in the jar as we notice these qualities. The immediate reward is exciting, but also the delay in knowing they are working towards a goal seems to help with more habits forming. Once the jar is full we do something out of the norm like a movie night, a day off of school, ice cream sundaes, extra xbox time on the weekend, etc. Nothing expensive and no presents - all intended for a family moment and celebration.
Gold Stars - this might be Amanda Tovey's signature parenting moment. She offers imaginary gold stars for positive attributes she notices in her children; the children keep track of their stars in their heads and when they get to 100 they get a trip to $5 Below to pick something out. She wins at life. No charts, no stickers, no keeping up with who gets what.
Happy Heart Chart - This idea came to fruition when I felt like I was constantly reprimanding a certain 3/4 year old's pouty attitude over every.single.decision. Getting dressed, eating a meal, brushing teeth, taking a nap; it was a non stop battle which led to constant correction which resulted in a lot of really long, extremely frustrating days - for both of us. I decided to make a chart and give a sticker for each activity he was able to do with a "happy heart." If he could get ten stars in a day he got a very tiny treat after dinner. I would be lying if I said it was a quick fix, but it has undoubtedly turned our days around and given us all something to encourage instead of what feels like a constant stream of reprimands.
Speaking Life - I feel silly even writing this, but the reality is that I needed this reminder more than any chart or reward system. My words can either raise my kids up to who I know God created them to be - or they can become weapons of the accuser. And when put like that, man do I want to choose the former. It is no wonder James devoted an entire chapter to the power of the tongue and Proverbs is full of wisdom regarding our speech; meditating on His word, knowing what He says about me AND my children, and spending time with Him will have a direct effect of what spews out of my mouth.
"For out of the abundance of the heart the mouth speaks" Matthew 12:34
"Keep your heart with all vigilance, for from it flow the springs of life." Proverbs 4:23
"The mouth of the righteous is a fountain of life," Proverbs 10:11
I noticed a significant different in one of my son's behavior when I started speaking out loud the great things I was noticing in him. This made all the difference when it was time to correct other areas.
5. Just Say Thank You - We often tell our children to treat others the way we want to be treated. This means we must treat them with respect! We will reap what we sow. If we are sowing seeds of frustration, irritability, sharpness in our voice, we will likely reap the same. But if our words are seasoned with grace, finishing up a request with the kind and respectful phrase, "Thank you!" - we are letting them know we see them and we appreciate them.
6. SMILE - Sarah MacKenzie once shared this at a Q&A, that she tries to make an intentional effort to smile at each child every day. Sounds slightly obvious, but I am sure any mom can confess that starting off the day on the wrong foot or with a vomiting toddler or waking up to a child rawring in your face like a T Rex can make it really really hard to smile. But smiling truly does have an affect on the attitude and emotional capacity… "A cheerful heart is good medicine but a crushed spirit dries up the bones." Proverbs 17:22
In what ways can YOU choose to make a difference in your child's life today by being their biggest encourager?
Needing more encouragement to speak LIFE into the hearts of your children? Fill out the form below for three FREE Scripture Printables to hang up as regular reminders!


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This take on Minted was made by
undefined from , a member of Minted's
community of independent artists.
Designers were asked to submit a chic and modern design.
If you see a design that is not available for sale, please email us and we will help you purchase the design.
To link to this design on other websites, copy & paste this HTML.
Watercolor winter wonderland. Enjoy the tiny details of this snowy scene.
, holiday, christmas, shoppers, watercolor, people, wreath, snow, snowy, blizzard, wrap, holiday, happy holidays, snow, weather, winter, christmas tree, pine tree, coat, warm, holly, joy, happy,
blue, red, green, orange, yellow, white
Non Foil-Pressed Gift Wrap
Feb 06 2018
What do you think of this? See anything you suggest adjusting? Would love some feedback!
I love the white background! It's very refreshing compared to the heavy colors typically used for holiday wrapping. Really nice work :)
Love this..perfect!
love this!
i wouldn't change a thing! its so fresh and unique :)
so cute!!
I keep coming back to look at this one, I love it that much :) It's such a perfect blend of whimsy, retro, and fresh. You've got my vote lady!
Beautiful! Love the colors.
@Jess Franks Thank you for your lovely comment! What a good feeling to know you've looked at it more than once : )
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@Mansi thank youuuu!
Thank you @Faith Dorn
Thanks Anna Lizzie and Juliet!
Love this so much! The little pops of color in the darling people illustrations on the crisp white background is perfect :)
Beautiful!! Love it!
Love this!! :)
This is just so perfect Patrice. Congrats and hoping you sell lots.
this is pretty neat and special
Lovely, Lovely :) Congratulations, Patrice on your Holiday win :)
We uncover design genius through ongoing design competitions. At Minted, all that matters is good design. Designers submit, and the Minted community votes to tell us what to sell.


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24,674 games
3,986,633 players
15,175,353 game plays
Games that have just been published
Straight Mario clone...Or is it?
Endless flying game
Collect all the coins and get to the door!
Alien adventures through space. Collect the coins and avoid the slime.
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Score as many points as possible without dying to the slimes.
collect all the gumdrops,and avoid touching the slime
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First game I have made, this is just a test :) I will now enter random letters to make u t
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38 from Berlin, GER
wasted/used up my youth mostly in Tresor, SO36 and Ostgut, musical influence is mostly from that period.
38 from Berlin, GER
wasted/used up my youth mostly in Tresor, SO36 and Ostgut, musical influence is mostly from that period.
25 from Berlin, GER
wasting my youth mostly in Berghain, musical influence is mostly from there.
Age: 27
Hometown: Waco, TX. USA
Influences (in no particular order):
A younger me? Tach jesacht.
29 from Helsinki, Finland.
I could list all kinds of influences, but in the end every genre that has managed to hold my sustainted interest can be traced to a single source.
That source is of course the soundtrack of the first Red Alert to which I listened to for literaly hundreds of hours as a kid. and we all know the really big formative events happen in childhood.
Metal, industrial, techno, synthpop, synth-whatever, it's all there if you listen for it.
I would probably also give some credit to my aunt's cassette collection of "space music", best-of-tapes of venerable electronic artists such as Jean-Michel Jarre, Giorgio Moroder and so on.
And come to think of it, endless hours of 80s hits and 90s eurodance I heard from car radio as a kid probably made me love synthwave and chord stabs.
43yrs, from Turku, Finland. Got my first synth (a Yamaha DX100) as a christmas present when I was 13 and have been making music on/off ever since. My musical tastes are very wide. For a long time I said that I love all music except reggae, trance and blues, but it seems that I've found things to love in all those genres too.
I was a semi professional dj for 18 years and retired from that thing last fall. Sold most of my 12" and 7" singles but still have thousands of vinyls etc. and keep buying them.
I'm 4 billion years old and come from Mars - friends call me Panspermia.
Nice to see Finn folks here =)
I am 30, brazilian from Amazon Jungle region, living in Helsinki, Finland.
I'm a 38 year old lady from Kalama, WA (all though I still feel, look & act 21… my mom calls it immature… I'm not immature, I'm youthful, THERE'S A DIFFERENCE!!!) So many artists inspire me, but I'll name a few favorites:
Dj Shadow
J Dilla (his solo stuff, also stuff he did with Tribe Called Quest & Busta Rhymes)
Led Zepplin
DJ Q-bert
Bob Marley
47, hannover, germany
I grew up listening to the the, soft cell, dead kennedys, pink floyd and john zorn, but i feel musically engaged nowadays to ellen alien, maya jane coles, ligeti, shostakovic, nine inch nails, dub trio, undisputed truth etc. it changes a lot
I'm a 36, from Chile but living in Germany. My first keyboard was a Yamaha PSS-11 when I was 11 or 12, then I got a bigger Yamaha and finally a Casio CTK-something when I was 17.
When I was in university I made a kinda cheesy electronic album with Fruity Loops and it seems I have lost all the songs, I also played around with ReBirth and Reason when they first appeared.
After many years just playing guitar and bass, I got interested in making electronic music again. Last year I bought my first HW synths, the 4 first Roland Boutiques, a TR-8 and even a Cirklon. Then I realized I just wanted some grooveboxes so I sold everything and got Elektron devices instead.
38, south uk, between portsmouth and southampton…
I mainly like guitar music up until 16, then I got introduced to techno, got into producing music around 98, bought a jp8080 and access virus b… started getting into more EDM/Aphex Twin/Autechre/Boards of Canada etc… bought a sidstation when they first came out… sold all equipment in 2010… started buying new stuff in 2017… now I have more than i did first time round…
26 since few days, from Italy, living in Marseille FR. First round with electronic music as an interest and an experience was from following the free party movement in Italy as a teen. then i moved to London at 19, i ve rediscovered punk and i've met breakcore for the first time and got lost in it. I've turned from punk to noise to techno to jungle to avantgarde to experimental to cheese stuff to lots of many others shades and shapes of music and to yours, maybe, as well. In this period I m listening to chick orea, throbbing ghristle, the last releases from Praxis and fever ray.
lol we're the same age and I also played the crap out of Red Alert, can't remember the soundtrack though. I bet it's one of those underlying influences I'm not even aware of, will have to go back and give it a listen. Most of the stuff I make and listen to sounds like pause menu music anyway.
34 Moscow, Russia. Let's call me Max it's easier and sounds better than my real name:)
Fell in love with electronic music (Techno , deep house and House) only 3 years ago, just started to explore music creation and and everything connected with it.
Detroit, enough said…
Sacramento California,
originally from a small town called Sonora near Yosemite.
Found my love for electronic music in the mid 90s when I accidentally ordered a copy of Aphex Twin's "Richard D. James Album" My older brother was also listening to a lot of Orbital at the time. Anything Rephlex / Warp I loved but also others like The Prodigy, Crystal Method, Distance to Goa, Chemical Brothers, Meat Beat Manifesto, the list goes on…
Started screwing around with electronic music production in the late 90s with a copy of Rebirth, nothing serious. Later on I purchased a copy of Reason 3.0 and would do many random sub par projects ITB through out the next decade off and on. Moved away from electronic music production in the late 2000s because I was working on rap music and writing a ton of lyrics (with mixed results).
Flash forward to 2014 and my wife picked me up a Korg EMX-1 for Xmas and I ditched any desire to be a lyricist. Ever since then I've jumped full blown into hardware, but still track in Cubase on my laptop. Also studying much more music theory and making much better songs than my younger years.
46 - Denver, Colorado via NJ, NC, OH and UT
I am inspired by music, all varieties and sounds around us, particular nature
I got to Elektron OT via guitar pedals and loopers then synths and samplers. Love making crazy noise
I'm 42 and live in a town on the coast in Ayrshire, Scotland that's quiet enough to be nice but it's dead easy to get a train up to Glasgow. I was born in Ayrshire too but moved to and grew up in Dumfriesshire… a wee village just outside Lockerbie.
I first started trying to write music in 94 when I went to Uni but that was a shambles as my 386sx40 PC didn't have a soundcard so I'd write stuff in Screamtracker, save to floppy disk and go round to my mate's house to listen to it on his Amiga.
My influences are all over the shoppe as I listen to all sorts of stuff but I find that the stuff I tend to write is mostly in the ball park of classic Warp, techno, dub, raster-noton, ambient etc etc…
43, midwest GER, started in the 90s with Fasttracker on PC and went on with similiar tracker software, also mangling my friends K2000… We did techno only, mostly trance and acid like tracks, inspired by BBC Steve Mason, small record stores which sold records from plastikman, harthouse like Labels (eye-q, etc…) and later on parties at FFM Omen (Väth, Dag). Meanwhile we did most steps in making music with rebirth and then reason… Then I stopped for a while, sometimes playing with reason and then started a while back with a Korg Electribe 2 or so because I did not want to use a PC anymore due to some hassle and also working all day with that dreaded Machine … ;)… Electribe didnt fit and was to limited and so I began buying and selling used as well as new gear to my setup today which I posted on the your setup thread…
Long story short, mostly I end up with monotone acid like patterns and tracks, because I like to listen to such tracks


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Used Pottery Barn Furniture Review Ale Return Policy
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Missouri authorities find body near submerged vehicle
ST. JOSEPH, Mo. (AP) - Authorities say a body has been found near a submerged vehicle just south of St. Joseph.
The Missouri State Highway Patrol said in a news release that the discovery was made Tuesday night after the Buchanan County Sheriff's Department responded to a report about the submerged vehicle. No occupants were located when the vehicle was removed from the water. The body was found during a subsequent search of the waters in the area.
The body was identified only as that of a white male.
The patrol says its Division of Drug and Crime Control will lead the investigation. No other information was immediately available.
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New Batman, Star Wars, and Ms Marvel!
Category Archives: NEWSLETTERS
Pulp Fiction Newsletter for Week of 11/11/15
Hey guys! The Friday newsletter is back! I'm going to do the best I can to keep it there. I'm running short on time so I just wanted to bring a few quick things to your attention. Please take a look at the upcoming events below. We have a back issue sale starting thisweekend as … Continue Reading ››
Pulp Fiction Newsletter Week of 11/4/15
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Pulp Fiction Newsletter Week of 10/26/15
Surprise again! I know I said the newsletter would start to come out on Fridays from now on, but...we had some technical difficulties. Hopefully we can get back on track with Fridays again after this. Ok, we have a somewhat lighter Wednesday, but some exciting deals of the week including another new original Vertigo … Continue Reading ››
Pulp Fiction Newsletter Week of 10/21/15
Surprise! So due to the ever-shifting landscape that is the Pulp Fiction retailer experience, the newsletter will now come out on Friday nights. Those of you that are subscribers will now have the entire weekend to look over the newsletter and make requests. Ok, let's get into the books! It's a new week and that … Continue Reading ››


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2013 Fed 100
Name: Danny Werfel Title: Controller, Office of Federal Financial ManagementAgency: Office of Management and Budget
A "consummate public servant." Werfel oversaw the integration of technology with other management disciplines and became the designated testifier before Congress on myriad IT issues. Known as "Mr. Shutdown," he spearheaded the planning for debt ceiling and sequestration impacts, and was influential in multiple migrations of financial management systems to modular approaches. "Danny is a consummate public servant who cares deeply about the improvement of government and the stewardship of taxpayer dollars to ensure we're not spending money on things that don't work," said Dan Chenok, executive director of the IBM Center for the Business of Government.
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Agencies are getting up to three more years on existing telecom contracts before having to shift to the $50 billion Enterprise Infrastructure Solutions vehicle.
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Large Format Printer
1 day left
- Recruiter
- Future Recruitment Ltd
- Location
- Hertfordshire
- Salary
- Up To £28K + Overtime
- Posted
- 16 Nov 2018
- Closes
- 16 Dec 2018
- Ref
- Contact
- Catherine Buckley
- Function
- Production
- Discipline
- Printing, Digital Printing
- Hours
- Full Time
- Contract Type
- Permanent
Up To £28K + Overtime (Paid at Time + ½) + 20 Days Holiday + 8 Bank Holidays + Pension
40 Hour Week
Our client is a large format print company based in the South East. They currently have a requirement for a Large Format Printer to join their growing production department.
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Trout Unlimited will replace seven culverts to improve aquatic habitat connectivity on and adjacent to the Nicolet National Forest. This work will reconnect 30 stream miles to improve passage by brook trout and other aquatic organisms. Trout Unlimited will first use existing surveys to establish a prioritization strategy for road–stream crossing projects. Based on the prioritization strategy, those structures with the highest priority for replacement will be identified and conceptual designs will be created. Lastly, the project will replace at least seven priority road–stream crossings using stream simulation methodology to restore aquatic organism passage, enhance riparian habitat, and reduce erosion. By reconnecting and restoring important coldwater rivers that have been physically disconnected by poorly designed road–stream crossings, this project will contribute to healthy, productive, and resilient fish communities in key subwatersheds on and adjacent to the Nicolet National Forest.
Grant Recipient:
Grant Awarded:
Lake Basin(s):
Project Location(s):
Iin northeastern Wisconsin on key coldwater streams and rivers on and adjacent to the Nicolet National Forest


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A novel synthetic C-1 analogue of 7-deoxypancratistatin induces apoptosis in p53 positive and negative human colorectal cancer cells by targeting the mitochondria: enhancement of activity by tamoxifen
- 353 Downloads
- Citations
The natural compound pancratistatin (PST), isolated from the Hymenocallis littoralis plant, specifically induces apoptosis in many cancer cell lines. Unlike many other chemotherapeutics, PST is not genotoxic and has minimal adverse effects on non-cancerous cells. However, its availability for preclinical and clinical work is limited due to its low availability in its natural source and difficulties in its chemical synthesis. Several synthetic analogues of 7-deoxypancratistatin with different modifications at C-1 were synthesized and screened for apoptosis inducing activity in human colorectal cancer (CRC) cells. We found that a C-1 acetoxymethyl derivative of 7-deoxypancratistatin, JC-TH-acetate-4 (JCTH-4), was effective in inducing apoptosis in both p53 positive (HCT 116) and p53 negative (HT-29) human CRC cell lines, demonstrating similar efficacy to that of natural PST. JCTH-4 was able to decrease mitochondrial membrane potential (MMP), increase levels of reactive oxygen species in isolated mitochondria, cause release of the apoptogenic factor cytochrome c (Cyto c) from isolated mitochondria, and induce autophagy in HCT 116 and HT-29 cells. Interestingly, when JCTH-4 was administered with tamoxifen (TAM), there was an enhanced effect in apoptosis induction, reactive oxygen species (ROS) production and Cyto c release by isolated mitochondria, and autophagic induction by CRC cells. Minimal toxicity was exhibited by a normal human fetal fibroblast (NFF) and a normal colon fibroblast (CCD-18Co) cell line. Hence, JCTH-4 is a novel compound capable of selectively inducing apoptosis and autophagy in CRC cells alone and in combination with TAM and may serve as a safer and more effective alternative to current cancer therapies.
KeywordsColorectal cancer Tamoxifen Combination therapy Apoptosis Autophagy
adenine nucleotide translocase
creatine kinase
colorectal cancer
- CypD
cyclophilin D
- Cyto c
cytochrome c
estrogen receptor
half-maximal inhibitory concentration
microtubule-associated protein 1 light chain 3
mitochondrial membrane potential
mitochondrial respiratory chain
- mtDNA
mitochondrial DNA
normal human fetal fibroblast
peripheral benzodiazepine receptor
permeability transition pore
relative fluorescence units
reactive oxygen species
succinate dehydrogenase subunit A
tetramethylrhodamine methyl ester
voltage-dependent anion channel
This work has been supported by the Knights of Columbus Chapter 9671 (Windsor, Ontario), NSERC, and a CIHR Frederick Banting and Charles Best Canada Graduate Scholarship awarded to Dennis Ma. Thank you to Carly Griffin for providing the pancratistatin results presented in this manuscript. We would also like to thank Colleen Mailloux for the critical review of this manuscript.
- 1.Parkin DM, Bray F, Ferlay J, Pisani P (2005) Global cancer statistics, 2002. CA Cancer J Clin 55:74–108PubMedCrossRefGoogle Scholar
- 2.Murphy JE, Ryan DP (2010) American Society of Clinical Oncology 2010 colorectal update. Expert Rev Anticancer Ther 10(9):1371–1373PubMedCrossRefGoogle Scholar
- 3.de Gramont A, Figer A, Seymour M, Homerin M, Hmissi A, Cassidy J, Boni C, Cortes-Funes H, Cervantes A, Freyer G, Papamichael D, Le Bail N, Louvet C, Hendler D, de Braud F, Wilson C, Morvan F, Bonetti A (2000) Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer. J Clin Oncol 18:2938–2947PubMedGoogle Scholar
- 4.Douillard JY, Cunningham D, Roth AD, Navarro M, James RD, Karasek P, Jandik P, Iveson T, Carmichael J, Alakl M, Gruia G, Awad L, Rougier P (2000) Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial. Lancet 355:1041–1047PubMedCrossRefGoogle Scholar
- 5.Maindrault-Goebel F, Louvet C, André T, Carola E, Lotz JP, Molitor JL, Garcia ML, Gilles-Amar V, Izrael V, Krulik M, de Gramont A (1999) Oxaliplatin added to the simplified bimonthly leucovorin and 5-fluorouracil regimen as second-line therapy for metastatic colorectal cancer (FOLFOX6): GERCOR. Eur J Cancer 35:1338–1342PubMedCrossRefGoogle Scholar
- 6.André T, Louvet C, Maindrault-Goebel F, Couteau C, Mabro M, Lotz JP, Gilles-Amar V, Krulik M, Carola E, Izrael V, de Gramont A (1999) CPT-11 (irinotecan) addition to bimonthly, high-dose leucovorin and bolus and continuous-infusion 5-fluorouracil (FOLFIRI) for pretreated metastatic colorectal cancer: GERCOR. Eur J Cancer 35:1343–1347PubMedCrossRefGoogle Scholar
- 7.Borst P, Rottenberg S (2004) Cancer cell death by programmed necrosis? Drug Resist Updat 7(6):321–324 [Epub 2005 Jan 11]PubMedCrossRefGoogle Scholar
- 8.Earnshaw WC (1999) Apoptosis. A cellular poison cupboard. Nature 397(6718):387–389PubMedCrossRefGoogle Scholar
- 9.Kekre N, Griffin C, McNulty J, Pandey S (2005) Pancratistatin causes early activation of caspase-3 and the flipping of phosphatidyl serine followed by rapid apoptosis specifically in human lymphoma cells. Cancer Chemother Pharmacol 56(1):29–38PubMedCrossRefGoogle Scholar
- 10.McLachlan A, Kekre N, McNulty J, Pandey S (2005) Pancratistatin: a natural anti-cancer compound that targets mitochondria specifically in cancer cells to induce apoptosis. Apoptosis 10(3):619–630PubMedCrossRefGoogle Scholar
- 11.Collins J, Rinner U, Moser M, Hudlicky T, Ghiviriga I, Romero AE, Kornienko A, Ma D, Griffin C, Pandey S (2010) Chemoenzymatic synthesis of Amaryllidaceae constituents and biological evaluation of their C-1 analogues. The next generation synthesis of 7-deoxypancratistatin and trans-dihydrolycoricidine. J Org Chem 75(9):3069–3084PubMedCrossRefGoogle Scholar
- 12.Baum M (2005) Adjuvant endocrine therapy in postmenopausal women with early breast cancer: where are we now? Eur J Cancer 41:1667–1677PubMedCrossRefGoogle Scholar
- 13.Mandlekar S, Kong ANT (2001) Mechanisms of Ttamoxifen‑induced apoptosis. Apoptosis 6:469–477PubMedCrossRefGoogle Scholar
- 14.Moreira P, Custodio J, Morena A, Oliveira C, Santos M (2006) Tamoxifen and estradiol interact with the flavin mononucleotide site of complex I leading to mitochondrial failure. J Biol Chem 281:10143–10152PubMedCrossRefGoogle Scholar
- 15.Siedlakowski P, McLachlan-Burgess A, Griffin C, Tirumalai SS, McNulty J, Pandey S (2007) Synergy of pancratistatin and tamoxifen on breast cancer cells in inducing apoptosis by targeting mitochondria. Cancer Biol Ther 7(3):376–384PubMedGoogle Scholar
- 16.Chatterjee SJ, McNulty J, Pandey S (2010) Sensitization of human melanoma cells by tamoxifen to apoptosis induction by pancratistatin, a nongenotoxic natural compound. Melanoma Res 2010 Mar 17. [Epub ahead of print]Google Scholar
- 17.Bruning A, Friese K, Burges A, Mylonas I (2010) Tamoxifen enhances the cytotoxic effects of nelfinavir in breast cancer cells. Breast Cancer Res 12:R45PubMedCrossRefGoogle Scholar
- 18.Griffin C, Karnik A, McNulty J, Pandey S (2011) Pancratistatin selectively targets cancer cell mitochondria and reduces growth of human colon tumor xenografts. Mol Cancer Ther 10(1):57–68PubMedCrossRefGoogle Scholar
- 19.Madesh M, Hajnóczky G (2001) VDAC-dependent permeabilization of the outer mitochondrial membrane by superoxide induces rapid and massive cytochrome c release. J Cell Biol 155(6):1003–1015 [Epub 2001 Dec 10]PubMedCrossRefGoogle Scholar
- 20.Simon HU, Haj-Yehia A, Levi-Schaffer F (2000) Role of reactive oxygen species (ROS) in apoptosis induction. Apoptosis 5(5):415–418PubMedCrossRefGoogle Scholar
- 21.Batandier C, Leverve X, Fontaine E (2004) Opening of the mitochondrial permeability transition pore induces reactive oxygen species production at the level of the respiratory chain complex I. J Biol Chem 279(17):17197–17204 [Epub 2004 Feb 11]PubMedCrossRefGoogle Scholar
- 22.Cochemé HM, Murphy MP (2008) Complex I is the major site of mitochondrial superoxide production by paraquat. J Biol Chem 283(4):1786–1798 [Epub 2007 Nov 26]PubMedCrossRefGoogle Scholar
- 23.Green DR, Reed JC (1998) Mitochondria and apoptosis. Science 281:1309–1312PubMedCrossRefGoogle Scholar
- 24.Stennicke HR, Salvesen GS (1999) Catalytic properties of the caspases. Cell Death Differ 6(11):1054–1059PubMedCrossRefGoogle Scholar
- 25.Kroemer G, Mariño G, Levine B (2010) Autophagy and the integrated stress response. Mol Cell 40(2):280–293PubMedCrossRefGoogle Scholar
- 26.McNulty J, Nair JJ, Griffin C, Pandey S (2008) Synthesis and biological evaluation of fully functionalized seco-pancratistatin analogues. J Nat Prod 71(3):357–363PubMedCrossRefGoogle Scholar
- 27.McNulty J, Larichev L, Pandey S (2005) A synthesis of 3-deoxy-dihydrocoricidine: refinement of a structurally minimum Pancratistatin pharmacophore. Bioorg Med Chem Lett 15:5315–5318PubMedCrossRefGoogle Scholar
- 28.Chen G, Wang F, Trachootham D, Huang P (2010) Preferential killing of cancer cells with mitochondrial dysfunction by natural compounds. Mitochondrion 2010 Aug. 14 [Epub ahead of print]Google Scholar
- 29.Leber B, Geng F, Kale J, Andrews DW (2010) Drugs targeting Bcl-2 family members as an emerging strategy in cancer. Expert Rev Mol Med 12:e28PubMedCrossRefGoogle Scholar
- 30.Gueorguieva D, Li S, Walsh N, Mukerji A, Tanha J, Pandey S (2006) Identification of singledomain, Bax-specific intrabodies that confer resistance to mammalian cells against oxidative-stress-induced apoptosis. FASEB J 20(14):2636–2638PubMedCrossRefGoogle Scholar
- 31.Miyashita T, Reed JC (1995) Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80(2):293–299PubMedCrossRefGoogle Scholar
- 32.Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T, Tokino T, Taniguchi T, Tanaka N (2000) Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science 288:1053–1058PubMedCrossRefGoogle Scholar
- 33.Nakano K, Vousden KH (2001) PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell 7:683–694PubMedCrossRefGoogle Scholar
- 34.Puthalakath H, Strasser A (2002) Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins. Cell Death Differ 9:505–512PubMedCrossRefGoogle Scholar
- 35.Fang YJ, Pan ZZ, Li LR, Lu ZH, Zhang LY, Wan DS (2009) MMP7 expression regulated by endocrine therapy in ERbeta-positive colon cancer cells. J Exp Clin Cancer Res 28:132PubMedCrossRefGoogle Scholar
- 36.Janakiram NB, Steele VE, Rao CV (2009) Estrogen receptor-beta as a potential target for colon cancer prevention: chemoprevention of azoxymethane-induced colon carcinogenesis by raloxifene in F344 rats. Cancer Prev Res Phila 2(1):52–59PubMedCrossRefGoogle Scholar
- 37.Warburg O (1956) On the origin of cancer cells. Science 123(3191):309–314PubMedCrossRefGoogle Scholar
- 38.Szatrowski TP, Nathan CF (1991) Production of large amounts of hydrogen peroxide by human tumor cells. Cancer Res 51(3):794–798PubMedGoogle Scholar
- 39.Carew JS, Zhou Y, Albitar M, Carew JD, Keating MJ, Huang P (2003) Mitochondrial DNA mutations in primary leukemia cells after chemotherapy: clinical significance and therapeutic implications. Leukemia 17(8):1437–1447PubMedCrossRefGoogle Scholar
- 40.Indo HP, Davidson M, Yen HC, Suenaga S, Tomita K, Nishii T, Higuchi M, Koga Y, Ozawa T, Majima HJ (2007) Evidence of ROS generation by mitochondria in cells with impaired electron transport chain and mitochondrial DNA damage. Mitochondrion 7(1–2):106–118PubMedCrossRefGoogle Scholar
- 41.Ishikawa K, Takenaga K, Akimoto M, Koshikawa N, Yamaguchi A, Imanishi H, Nakada K, Honma Y, Hayashi J (2008) ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis. Science 320(5876):661–664PubMedCrossRefGoogle Scholar
- 42.Adam-Vizi V, Chinopoulos C (2006) Bioenergetics and the formation of mitochondrial reactive oxygen species. Trends Pharmacol Sci 27(12):639–645PubMedCrossRefGoogle Scholar
- 43.Brandon M, Baldi P, Wallace DC (2006) Mitochondrial mutations in cancer. Oncogene 25(34):4647–4662PubMedCrossRefGoogle Scholar
- 44.Patel BP, Rawal UM, Dave TK, Rawal RM, Shukla SN, Shah PM, Patel PS (2007) Lipid peroxidation, total antioxidant status, and total thiol levels predict overall survival in patients with oral squamous cell carcinoma. Integr Cancer Ther 6(4):365–372PubMedCrossRefGoogle Scholar
- 45.Kumar B, Koul S, Khandrika L, Meacham RB, Koul HK (2008) Oxidative stress is inherent in prostate cancer cells and is required for aggressive phenotype. Cancer Res 68(6):1777–1785PubMedCrossRefGoogle Scholar
- 46.Fruehauf JP, Meyskens FL Jr (2007) Reactive oxygen species: a breath of life or death? Clin Cancer Res 13(3):789–794PubMedCrossRefGoogle Scholar
- 47.Berridge MV, Herst PM, Lawen A (2009) Targeting mitochondrial permeability in cancer drug development. Mol Nutr Food Res 53(1):76–86PubMedCrossRefGoogle Scholar
- 48.Halestrap AP (2009) What is the mitochondrial permeability transition pore? J Mol Cell Cardiol 46(6):821–831PubMedCrossRefGoogle Scholar
- 49.Corsi L, Geminiani E, Baraldi M (2008) Peripheral benzodiazepine receptor (PBR) new insight in cell proliferation and cell differentiation review. Curr Clin Pharmacol 3(1):38–45PubMedCrossRefGoogle Scholar
- 50.Meffert G, Gellerich FN, Margreiter R, Wyss M (2005) Elevated creatine kinase activity in primary hepatocellular carcinoma. BMC Gastroenterol 5:9PubMedCrossRefGoogle Scholar
- 51.Palmieri D, Fitzgerald D, Shreeve SM, Hua E, Bronder JL, Weil RJ, Davis S, Stark AM, Merino MJ, Kurek R, Mehdorn HM, Davis G, Steinberg SM, Meltzer PS, Aldape K, Steeg PS (2009) Analyses of resected human brain metastases of breast cancer reveal the association between up-regulation of hexokinase 2 and poor prognosis. Mol Cancer Res 7(9):1438–1445PubMedCrossRefGoogle Scholar
- 52.Kim GJ, Chandrasekaran K, Morgan WF (2006) Mitochondrial dysfunction, persistently elevated levels of reactive oxygen species and radiation-induced genomic instability: a review. Mutagenesis 21(6):361–367PubMedCrossRefGoogle Scholar
- 53.Pedersen PL (2008) Voltage dependent anion channels (VDACs): a brief introductionwith a focus on the outermitochondrial compartment's roles togetherwith hexokinase-2 in the "Warburg effect" in cancer. J Bioenerg Biomembr 40(3):123–126PubMedCrossRefGoogle Scholar
- 54.Chen G, Izzo J, Demizu Y, Wang F, Guha S, Wu X, Hung MC, Ajani JA, Huang P (2009) Different redox states in malignant and nonmalignant esophageal epithelial cells and differential cytotoxic responses to bile acid and honokiol. Antioxid Redox Signal 11(5):1083–1095PubMedCrossRefGoogle Scholar
- 55.Dalby KN, Tekedereli I, Lopez-Berestein G, Ozpolat B (2010) Targeting the prodeath and prosurvival functions of autophagy as novel therapeutic strategies in cancer. Autophagy 6(3):322–329 [Epub 2010 Apr 26]PubMedCrossRefGoogle Scholar


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Situated in Rafaela, Alquileres Temporarios Rafaela features accommodation with free WiFi, a seating area, a flat-screen TV and a kitchen.
An oven and kettle are also offered.
The apartment offers a terrace.
Rafaela Race Track is 8 km from Alquileres Temporarios Rafaela. Sauce Viejo Airport is 113 km from the property....
|Bv Roca 465 Edificio Virginia 1


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|Dylan Moore
|Georgia King
|Paul Amos
|Jennifer Olympia Bentley
|Josef Altin
|Drashti Dhami
|Amelia Heinle
|Jessica Rose
|Amanda Hale
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|Alexandra Stamler
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|Joely Richardson
|Zuzanna Szadkowski
|Barbara McNair
|Samantha Burton
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|Vanessa Ross
|Darlene Cates
|Greta Gerwig
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|Lucy Liemann
|Eric Sykes
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|Thomas Robinson
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|Jane McNeill
|Bernadette Peters
|Ashley Taylor
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|Rory Cochrane
|Judyann Elder
|Dorothy Stratten
|Sandra Bernhard
|Barbara Sukowa
|Eddie Redmayne
|Niamh Wilson
|Master Vinayak
|Bobby Lee
|Judy Norton
|Inga Cadranel
|Lisa Whelchel
|Reese Hartwig
|Jill Schoelen
|Chin Han
|Jeremy Brett
|Leanne Lapp
|Meaghan Rath
|Jennifer Alden
|Robert Singer
|Kathleen Wilhoite
|Rhonda Fleming
|Ron Cook
|Julia Davis
|Carole King
|Charlie Schlatter
|Kathleen Lloyd
|Anthony Lemke
|Phillip Rhys
|Riya Sen
|Adam Wylie
|Sharon Tate
|Elisa Donovan
|Greta Garbo
|Sonja Richter
|CeeLo Green
|Blake Shelton
|Julia Kelly
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|Tait Fletcher
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|Patton Oswalt
|Satish Shah
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|Gwen Verdon
|Carlee Baker
|Nicole Scherzinger
|Elizabeth Thai
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|Dabney Coleman
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|James MacArthur
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|Ronen Rubinstein
|Andrew Astor
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|Janet Kidder
|Anthony Konechny
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|Claire Stansfield
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There either is or is not, that's the way things are. The colour of the day. The way it felt to be a child. The saltwater on your sunburnt legs. Sometimes the water is yellow, sometimes it's red. But what colour it may be in memory, depends on the day. I'm not going to tell you the story the way it happened. I'm going to tell it the way I remember it.
The Lizzie Bennet Diaries is an innovative, original episodic video and social media series produced for the web. Adapting Pride and Prejudice to the modern era, Lizzie Bennet tells the classic Jane Austen tale from the point of view of an Elizabeth "Lizzie" Bennet who grew up in a world of cell phones, video cameras, and social media. The series was created by popular YouTube personality Hank Green and Streamy Award winning web video writer Bernie Su.
The holiday season is bringing more than cheer for actress Jessica Capshaw. The Grey's Anatomy star announced on Monday that she and her husband, Honest Company co-founder Christopher Gavigan, are expecting their fourth child. "The holidays have certainly arrived … All of our lives are being added to by the lights, the music and cheer!!" she captioned a photo of her family at a Christmas tree farm on Instagram. "This year our family has reason to further broaden our smile … baby number four is on the way!! I am a lucky, lucky girl…"
The quickest way to tell whether an actor is serious about his or her career is to look at their "headshot".Is it a professional photo? Or is it a snapshot taken on prom night? If you're using a snapshot, it's like showing up to race the Indy 500 in a VW Beetle. Nobody is going to take you seriously. I'm sorry, people… you can send me as much angry e-mail as you want about this, but it's true! Don't tell me you're destined to be a major Hollywood star but you cannot scrape together the cash to get professional headshots.
The Grinch from Dr. Seuss' How the Grinch Stole Christmas! The Musical stole the spotlight at the Empire State Building's 86th Floor Observatory December 14, 2012, to promote the musical's limited holiday engagement. Discover the magic of Dr. Seuss' classic holiday tale as it comes to life on stage. Featuring the hit songs "You're A Mean One, Mr. Grinch" and "Welcome Christmas," The Grinch discovers there's more to Christmas then he bargained for in this heart-warming holiday classic.
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My plumbing experience was to have the plumbing disconnected under the sink so the counter top and new sink could be installed. I thought the service of $115 was high, but usually if there is an additional fees, it is usually rolled into the cost of repairs or labor. This company also charged 3.75 % for putting it on a credit card, which was not mentioned until I received the invoice in the mail after paying on the phone.
I am so happy to say I have found a plumber I can trust to do good work for a fair price and who is responsive. Ben (owner) of Bayz Plumbing is experienced, prompt and professional. He gets right back to you to schedule a time, lets you know if he is running a few minutes late. He installed a new toilet for me: bought it, picked it up and installed it, removed the old one. Even anticipated I might want a self closing and had one on hand. He was right... I totally did want one but hadn't thought to inquire about it. That's the kind of small, thoughtful service that makes a good experience even better. Throughout the entire process, he was as tidy as could be, keeping the work space clean, taking care to cover his shoes for the carpet. Even his tool bag is tidy - a good sign in my book. Ben enjoys what he does and it's reflected in the quality of his work and customer service. Highly recommend.
Drain cleaning Clogged drains are the last thing your home needs and they don't always make for the most successful DIY projects. If you happen to get a clog that you can't tackle on your own, let Master Rooter Plumbing tackle the job for you. Whether it is a slow running drain, sewer smells coming from the bathtub, or something that should not be flushed making a trip down the toilet, battling clogged drains is one thing you don't have to do! Let Master Rooter provide our premier service and help give you one less stress to worry about! [/one_half_last] Jetting After years of continued usage your plumbing is bound to become blocked with grease, sediment, and other sludge. The safest way to ensure a clean system is to "flush the pipes" with a high-pressure jetting treatment. Using state-of-the-art technology, the team at Master Rooter Plumbing can use high pressure water jets to knock out sludge build-up and keep your sewer lines and pipes running smoothly. [/one_half_last] Sewer camera/videos Inspecting a new home before buying or remodeling? Checking to see if your septic system is still running smoothly? Lost a valuable item down the drain? These are many of the reasons why you may need your to take a close and personal view of your sewer or drains with our plumbing video equipment. Master Rooter Plumbing's plumbing video inspection equipment is a non-invasive and efficient way of nipping potential sewer, septic, and drain problems in the bud and insuring your plumbing systems are running smoothly. Toilet/sink repair and replacement Chipped and cracked porcelain or ceramic toilets and sinks aren't just physically unappealing, they open up the chance for leaks and water damage to your home. Let the highly-trained team at Master Rooter Plumbing expertly repair your sink or toilet and prevent your home from getting further damage. Or maybe you are interested in replacing your toilet or sink, whether time has taken its toll or you're just interested in giving your bathroom a new, modern look, you can trust Master Rooter plumbing to masterfully swap out your toilet or sink. Water service repair As your home gets older, so does your home's connection to a main water line. Over time, your home's connection to an external water source can leak or break due to extreme temperatures, corrosion, the natural shifting of soil, or simply natural aging. If you are experiencing an unnaturally soggy lawn, water discoloration, or a severe drop in water pressure, your home may be in need of Master Rooter Plumbing's water service repair. Our expert team can pinpoint breaks in your water line and repair the damage, allowing your home to once again have access to clean water. Sump repair and replacement Sump pumps are a crucial means of protecting your home from flooding and basement damage. A sump pump is designed to ensure that water drains away from your home's foundation and if it fails you open your home up to the potentially disastrous results. At Master Rooter Plumbing, our highly-trained technicians are skilled in repairing your sump pumps to get them back into fighting shape, or replacing those that have given up the ghost. Your home's sump pump is your first line of defense against flood damage, don't let your home be unprotected. Water heater service and repairs No one wants to wake up to a cold shower and it is Master Rooter Plumbing's goal to make sure your day starts off right. Whether your home has a conventional water heater, a tankless water heater or hybrid heat pump system, our team of plumbers are available 24-7 to repair your water heater and make make sure you never have to worry about cold showers again. Trust Master Rooter Plumbing's team to service and repair your water heater today! Toilet leaks/runs A leaky toilet is the last thing anyone wants. If it's the hassle (and higher utility cost) of water constantly running in a toilet's tank, or water leaking out of the toilet's base causing water damage, Master Rooter Plumbing are your experts for the job! We offer 24-7 emergency repair to help solve your leaky toilet problems, so whether it is water damage or higher water costs, let Master Rooter Plumbing be your solution. Lavatory/ bathroom upgrades and remodel Is your home in need of a updated bathroom? Then let the team at Master Rooter Plumbing provide our stellar bathroom remodel service. Our years of bathroom remodeling experience allow us to safely avoid all of the common pitfalls that homeowners can fall into when remodeling on their own. We can both recommend the best possible fixtures for your bathroom or lavatory as well as install them with minimal disruption to your everyday home life. Kitchen upgrades and remodel Ready to upgrade your kitchen to a whole new level? Master Rooter Plumbing knows all of the ins and outs of ensuring your home has the best possible kitchen it deserves. Our trained technicians are no strangers when it comes to kitchen remodeling and can help you choose and recommend the best possible finishes and fixtures for the kitchen of your dreams. If your kitchen remodeling job becomes too big for just your hands, let Master Rooter Plumbing help by calling 720-434-3406. Kitchen, lavatory faucet repairs and upgrades The drip, drip, drip or a leaky faucet has become a symbol of all things annoying but it's not the only problem that can happen to your bathroom or kitchen faucet. That drip can eventually lead to a faucet that won't stop running, or worse yet, a faucet that won't turn on at all. Whether it's just a drip or something more serious, Master Rooter Plumbing is up to the task to help solve your leaky faucet problems! Call us 24-7 at 720-434-3406 to help you with your minor dripping annoyances or full-blown faucet emergencies. Main line service The main water line to your house is the source of clean, fresh water to your entire home and ensuring that it is corrosion free, damage free, and blockage free is incredibly important. The technicians at Master Rooter Plumbing have access to some of the most state-of-the-art technology to investigate just what exactly can be effecting your main water line. We eliminate the guesswork and can quickly diagnose whatever issues could be disrupting the flow of water into your home. If you are experiencing a disruption or service, a drop in water pressure or discolored water, call the team at Master Rooter Plumbing 24-7 to get your clean water back on track. Tankless water heaters Whereas a traditional water heater will collect water and heat it for future use, tankless water heaters heat water directly without the need of a tank, basically making them the "on-demand" version of water heaters. While not the best option if you plan on doing things like simultaneously taking a shower while washing clothes, they generally are a more cost-effective water-heating option for most homes. At Master Rooter Plumbing, we are experts in all things tankless water heating. If your tankless water heater experiences any issues or simply needs routine maintenance, call our team of expert plumbing technicians. Underground repairs The biggest issue with sewer and plumbing lines is that they are hidden from the naked eye. Buried underground the last thing you want to do is blindly dig around your yard with a shovel trying to identify the source of a leak. At Master Rooter Plumbing, our team of technicians can use our years or experience and state-of-the-art equipment to non-invasively identify where your damage is coming from so that it can be addressed effectively and quickly. Excavation Plumbing and sewer systems are amazing conveniences and by hiding pipes underground, these amazing systems are able to do their jobs without making your home's yard look less appealing. The downside however is that if one of these systems becomes damaged do to corrosion, the soil shifting, or just simply because of time, there is not way to repair or service them without excavating the ground to locate them damage. At Master Rooter Plumbing, we are highly trained in locating breaks and damage before we even begin the process of excavation. And whether it's something that can be addressed simply with shovels, or maybe something requiring larger equipment, we strive to effect the overall look of your yard as little as possible. So call Master Rooter Plumbing today if you are in need of excavation services! Let us be your "go to" Plumber in Denver. If you're experiencing difficulty with your plumbing system, or you want to avoid one altogether, contact or call Master Rooter today for an estimate!
Abacus' residential and commercial plumbers are proficient at repairing all kinds of plumbing issues, including gas and electric water heaters, slab leaks, leaky pipes to hydro jetting clogged drains. Many plumbing problems are not DIY types of jobs, call Abacus so one of our licensed plumbers can fix your problem. Our plumbers are not only knowledgeable but their customer service skills will meet or exceed your expectations.
Don't flush floss, tampons, or even so-called "flushable" wipes. They don't break down like toilet paper does and can come back to haunt you later. "Toilets are more water-efficient now than they were 20 years ago, so there sometimes isn't enough volume in the flush to force debris down," says Marcin Wroblewski, president of ExpressRooter Plumbing in Toronto. "An object will get lodged in the trap and cause blockage when waste builds up days later."
Worst contractor experience ever. Vlad came out to replace a pedestal sink and toilet set in our master bathroom. He cracked our $300+ sink basin and installed the toilet improperly causing hazardous sewer gas to enter our home. We have since purchased a new sink basin and hired a handyman to install it who, to our dismay, found that Vlad had removed the rubber washers from both the hot and cold faucet supply lines. Now we will need to call the handyman back to take apart our brand new toilet to determine what is causing the sewer gas smell.
Every family will be faced with plumbing problems from time to time, but that does not mean that they must deal with those problems on their own. In fact, it is best if plumbing problems are dealt with by a professional plumber who has the skill and experience to leave your systems safe and functioning. Without the help of a licensed plumber, a homeowner may be saddled with a plumbing issue that they simply cannot overcome on their own. At Petri Plumbing, we are an experienced Manhattan plumber ready to help you and your family with all of your plumbing issues, take a look at what your neighbors are saying in our customer reviews.
If you want a handyman to install a faucet or fixture you picked up at Home Depot or Lowes, Benjamin is not your guy. If you want someone who cares about quality and the craft of plumbing, I highly recommend Bayz. Benjamin is prompt, friendly, and does his work with pride. For example, he received the wrong soap dispenser to go with our new kitchen faucet. Honestly, I wouldn't have noticed it. But Benjamin took the time to call me, and arrange to make it right the next day. I wish everyone cared as much about his/her work. Highly recommended!
For fast, dependable plumbing service every time, contact Rhino Rooter Plumbing, Southern California's most trusted plumbing company. Our highly trained and knowledgeable staff can handle all of your plumbing needs. Your professional Torrance Plumber is highly trained and available to assist with your plumbing or emergency plumbing needs. This includes everything from plumbing repair, drain de-clogging, leak repairs, sewer and trenchless serves, water-based appliances, gas lines, and other specialized jobs. With our Torrance plumbing company you will receive the highest level of customer service and only top of the line first rate products that are durable and will last for years to come.
With Latta Plumbing Service, you'll have upfront pricing, friendly and knowledgeable plumbing contractors who arrive at your door on time, in uniform, and work carefully and efficiently on your home's plumbing so you can get back to your routine with the least amount of disruption possible. Your 100% satisfaction is our dedication and commitment to getting the job done right the first time. Click Here to check out our online reviews or click here take advantage of our current internet specials and discounts for your plumbing service.
Our 14 year old water heater took a tank on Monday - Mr. Mohammad Bagheri and his co worker came out the next day and gave us an estimate. After dealing with our insurance we called Mohammad this morning (Thursday) to see if he could get us in and he said he'd be here this afternoon. Mohammad and his co worker saved our family! We were truly miserable without hot water. They squeezed us into their already busy day and showed up at 630pm in Marysville the exact time they had said in the morning. We were so grateful they squeezed us in and got us a new tank! They drove all the way from Seattle to Marysville! They had the whole thing installed and working within an hour and a half. Thanks so much Mohammad! Definitely will use and recommend again! Also prices were competitive and better than other companies. Great service.
I had sewer back up problem and called Mr. Rooter on Sunday. One George arrived at scheduled time. Explained about snaking and hydro jetting. Scheduled service for Monday noon as it was already dark. George called and came ahead of schedule at around 10.40AM. Tried Hydro-jetting as well as snaking. Removed lots and lots of roots, but still could not open up the drain. His supervisor came and located the blockage which was very close to the city sewer line. Actually, the sewer line belongs to the county and he was not able to give an accurate estimate until he calls the county office and finds out their regulations etc. But, he did mention that couple of large trees need to be cut down, need to dig down and replace the broken (not sure how it was concluded, experience may be - will give him benefit of doubt) clay pipes with PVC and the cost will easily run upwards of 10K!!


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Jordan King will take part in his first Indianapolis 500 in 2019 after signing a one-race deal with Rahal Letterman Lanigan Racing. The event will be the British driver's first oval race.
2017 Indianapolis 500
Ed Jones has secured a part-time drive in the 2019 IndyCar season after Ed Carpenter Racing announced a deal between themselves and Scuderia Corsa. Jones will drive on the road courses and street circuits.
IndyCarSeason Review
Season Review: 2018 Verizon IndyCar Series – Dixon makes a bid for the history books with his fifth title
After a season of intense on-track action once again, the Verizon IndyCar Series has concluded for the year, with Scott Dixon emerging as the champion for the fifth time. Here, TCF takes you through the key points of the year that ultimately went on to decide the championship.
After taking his first IndyCar win in over a year and the third of his career, Takuma Sato has described the Sunday of the Grand Prix of Portland weekend as "one of the most beautiful days" of his life.
Takuma Sato won the 2018 IndyCar Grand Prix of Portland after fending off a late-race challenge from Ryan Hunter-Reay. Championship leader Scott Dixon finished fifth after being caught in a crash on lap one.
This weekend, the Verizon IndyCar Series heads to "Motor City" for the 2018 Chevrolet Duel in Detroit. Two races await the drivers, one on Saturday and one on Sunday. Here, Jordan Groves takes you through everything you need to know ahead of the double-header race weekend.
The wait is almost over. The Verizon IndyCar Series is just days away from it's biggest race of the season. Ahead of this weekend's 102nd running of the Indianapolis 500, TCF's Jordan Groves takes you through everything you need to know.
Reports have emerged today that McLaren staff are in Indianapolis to discuss a potential full-time 2019 IndyCar entry. Sources suggest that the team are looking at a partnership with Andretti Autosport or Rahal Letterman Lanigan Racing.
FIA WECFeaturesOpinion
Opinion: Why Alonso's FIA World Endurance Championship arrival left a bitter aftertaste
A lack of competition and a subdued showing from Alonso are just two of the reasons why Fernando's first win for five years wasn't the occasion it should have been.
Two-time Indianapolis 500 champion, Juan Pablo Montoya, announced yesterday that he would be missing the 2018 running of the famous IndyCar race to instead prepare for his Le Mans debut in June.
An IndyCar programme will be put on the back burner until McLaren are successful again in Formula 1, according to McLaren Executive Director Zak Brown.
Graham Rahal feels Fernando Alonso was destined to be a frontrunner in the Indianapolis 500 in 2017 thanks to the preparations the two-time Formula 1 World Champion had at the Indianapolis Motor Speedway.
Formula 1 has been named the fastest-growing sport on social media, and also saw increasing TV numbers, in the first post-Bernie years
The winning driver and team of the 2017 Indy 500, Takuma Sato and Andretti Autosports, have been presented with mini versions of the Indy 500 trophy this week.
IndyCar24 Hours of Le MansBTCCEuropean Formula 3FeaturesFIA WECFormula 1Formula EMacau Grand PrixMotoGPTCR International Series
TCF PICKS 2017: Race of the year
With the Competitor of the year and Team of the year picks already out of the way, we move our focus to the races of the year, as picked by our team of writers.


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Scripts For Kids
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Blue Shampoo For Brassy Blonde Hair No person is birthed with the similar hair style. Article cleaning, my hair feels somewhat dry and shabby, most likely on account of the presence of SLS within it. There are actually a considerable amount of wonderful colors delivered and boxed hair dye has actually truly improved over the last few many years.
If your hair hardly made lighter during the course of the quite 1st bleach, it is not practical to carry on seeking to achieve a pale colour. Generally, you require to carefully select a hair dye item, after speaking to a healthcare provider. Simply put, in addition to being actually non-toxic, it additionally ought to deal with grey hair and be actually foreseeable.
Your hair provides you the capacity to reveal your unique identity. As a result, if you feel that you may intend to apply for the hair dye, do it quickly summarily any second. You will similar to to possess well-conditioned hair!
Carry out find the aid of a skilled colorist if you wish to draw your hair through a hat or even aluminum foil in some highlights. Your hair is very first cleaned with a making clear hair shampoo thus as to eliminate depositions of oil, dirt, and various other forms of deposit. Based on how dark your hair was actually expected to start with, you are going to most likely are going to require to use bleach much more than as soon as to acquire a pale yellowish shade that may be colored white. For those who possess quite dark hair, you may intend to lighten it with bleach initially. If you would certainly such as dark red colored hair, then you may pick a copper boat.
Blue Shampoo For Brassy Blonde Hair As soon as you have actually colored your hair you'll be able to acquire a different colors protector hair shampoo of the exact brand to wash your hair. The hair is place into a bowl of bare water. To decide whether you wish to make use of a pure hair dye or even an establishment bought one that has chemicals, presume when you will definitely utilize it. All-natural black hair is substantially easier to reduce than black dye is, and the procedure may be completed in the comfort of your residence.
Also in the event you carry out have actually kicked back hair, there are actually particular hair colour colors that may be selected for black ladies. The quite initially necessary issue to become dealt with while tinting your hair is the appropriate type of hair dye. The hair will be actually extra nourished whenever the components which are actually going to be actually related to it are actually secure and potent. To become particular that all your hair obtains the crucial nutrients and oils coming from your items, it is actually suitable to separate the hair right into manageable parts. Just before it is actually possible to dye your hair blonde, you will definitely require to determine the state of your hair. If you are actually not exactly sure of the absolute most effective blonde hair highlights for you, consult with a professional colorist to analyze your options.
Your hair shows up perspective and will definitely increase your facial components. Its greatest in case you give away clean your hair for a married couple times just before lightening. You are able to additionally generate a hair dye with tea. If your hair is colored, you'll usually demand a tough hair conditioner and a remarkably gentle hair shampoo to care for it. Currently you recognize how to color grey hair, go ahead of time of time and include colour back right into your lifestyle! Consider your grey hair as unique, given that it is. Along with more protection to begin with, grey hair will not be actually as obvious blog post each colouring.
You just need to check how powerful the hair shampoo is and how much time it will definitely require to deal with the colour. There are actually many sort of hair shampoo on the market place. If you pick a great purple hair shampoo, it'll be actually the only sort of cartridge and toner you really want Blue Shampoo For Brassy Blonde Hair.