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- Research article
- Open Access
- Open Peer Review
Expression of a novel carbonic anhydrase, CA XIII, in normal and neoplastic colorectal mucosa
© Kummola et al; licensee BioMed Central Ltd. 2005
- Received: 13 December 2004
- Accepted: 18 April 2005
- Published: 18 April 2005
Carbonic anhydrase (CA) isozymes may have an important role in cancer development. Some isozymes control pH homeostasis in tumors that appears to modulate the behaviour of cancer cells. CA XIII is the newest member of the CA gene family. It is a cytosolic isozyme which is expressed in a number of normal tissues. The present study was designed to investigate CA XIII expression in prospectively collected colorectal tumor samples.
Both neoplastic and normal tissue specimens were obtained from the same patients. The analyses were performed using CA XIII-specific antibodies and an immunohistochemical staining method. For comparison, the tissue sections were immunostained for other cytosolic isozymes, CA I and II.
The results indicated that the expression of CA XIII is down-regulated in tumor cells compared to the normal tissue. The lowest signal was detected in carcinoma samples. This pattern of expression was quite parallel for CA I and II.
The down-regulation of cytosolic CA I, II and XIII in colorectal cancer may result from reduced levels of a common transcription factor or loss of closely linked CA1, CA2 and CA13 alleles on chromosome 8. Their possible role as tumor suppressors should be further evaluated.
- Carbonic Anhydrase
- Dorzolamide
- CA13 Gene
- Common Transcription Factor
- Carbonic Anhydrase Gene
Carbonic anhydrases (CAs) are a growing family of zinc-containing metalloenzymes that have an important role in maintaining the pH homeostasis by catalysing the reversible hydration of carbon dioxide, CO2 + H2O ↔ HCO3 - + H+. This family includes at least twelve enzymatically active isozymes, whose subcellular localization, tissue distribution and kinetic properties differ. Five of the isozymes are cytosolic (CA I, II, III, VII and XIII), four are membrane associated (CA IV, IX, XII and XIV), two are mitochondrial (CA VA and VB) and one is a secretory form (CA VI) [1–6]. CAs contribute to several important biological functions, such as respiration, bone resorption, renal acidification, gluconeogenesis and formation of cerebrospinal fluid and gastric acid [1, 7].
It is typical for solid tumors to create a pH gradient between the intracellular and extracellular compartments by acidifying the surrounding tissue to lower pH value than in adjacent normal tissue. Extracellular acidification has been associated with many tumor progression effects, such as loss of intercellular adhesion, increased metastasis and migration, increased rate of mutations and reduced DNA repair and upregulation of growth factors and proteases [4]. In order to maintain the pH gradient, tumor cells express ion transport proteins, including vacuolar H+-ATPase, Cl-/HCO3 - exchanger and Na+/H+ exchanger [8, 9]. Previously, lactic acid has been considered a major source of acidity in tumors [4]. More recent studies have indicated, however, that carbon dioxide also makes a significant contribution to the tumor acidity, which strongly implies to the importance of CA activity in oncogenesis. This hypothesis has been indirectly supported by the recent findings that several CA inhibitors may suppress the invasion capacity of malignant cell lines [4].
CA XIII is a novel enzyme, which is expressed in several human tissues including salivary glands, kidney, small intestine, colon, uterus and testis. Modelling of CA XIII protein revealed that is a globular molecule, and it has the highest (about 60%) identity with cytosolic isozymes CA I, II and III. Therefore, CA XIII is clustered as cytosolic/intracellular isoform. In the previous report, we described the production of recombinant mouse CA XIII protein, which was used in detailed activity and inhibition studies [2, 10]. CA XIII demonstrated moderate CA catalytic activity with k cat /K m of 4.3 × 107 M-1s-1, and k cat of 8.3 × 104 s-1 at 25°C and pH 7.5 [2]. Interestingly, CA XIII showed unique inhibitory properties compared to CA I, II and IX [10]. The clinically used sulfonamides including acetazolamide, methazolamide, dichlorophenamide, and dorzolamide demonstrated potent CA XIII inhibition, with K i's in the range of 17–23 nM. Another group of inhibitors, the sulfanilyl-derived compounds, obtained by reaction of aminosulfonamides with 4-acetamido-benzenesulfonyl chloride showed very potent CA XIII inhibitory properties, with K i's in the range of 1.3–2.4 nM, whereas these compounds were generally much less effective as inhibitors of isozymes I, II, and IX.
Different CA isozymes have become attractive targets in studies aimed at molecular mechanisms of carcinogenesis. CA IX and XII have been clearly associated with certain types of cancer [11–21]. Also cytosolic isozymes CA I and II have been investigated in some tumors including colorectal cancer [22, 23]. Since there was no previous data on CA XIII in tumors, we collected a series of colorectal neoplasias and adjacent normal tissues, and analyzed them by an immunohistochemical staining method for the expression of this novel isozyme.
The rabbit anti-mouse/human CA XIII antibody has been described in a recent article [2]. It was raised against a synthetic peptide (AC-) DGDQQSPIEIKTKEC (-COOH). The affinity and specificity of the antibody was confirmed by ELISA titre analysis, western blotting and immunohistochemistry. In immunohistochemical staining, CA XIII has shown a distinctly different distribution pattern compared to the localization of CA I or II [2]. This finding indicates that the anti-CA XIII antibody does not cross-react with CA I or II under the present staining conditions. Rabbit antisera against human CA I and II have been produced and characterized earlier [24].
The normal tissue samples from the large intestine and the corresponding benign and/or malignant neoplastic samples were prospectively collected at Oulu University Hospital (Oulu, Finland). The normal samples were excised separately 20 centimeters proximally from the tumor resection site. The study was approved by the Ethics Committee of Oulu University Hospital and performed according to the guidelines of the Declaration of Helsinki.
32 distinct areas (both normal tissue and pathological lesions) of the human colorectal mucosa were examined from 12 patients. They consisted of 11 separate samples of histologically normal human colon or rectum and 17 colorectal lesions, including 6 adenomas and 11 adenocarcinomas. In 4 samples, normal tissue was found adjacent to the neoplasm and was included in the analyses. The grade of dysplasia was moderate in 3 and grave in 3 adenomas. The group of 11 malignant colorectal tumors consisted of 4 well-differentiated and 4 moderately differentiated adenocarcinomas, and 3 adenocarcinomas with a mucinous component. It should be noted that each patient had either one or more (1–3) lesions which were analyzed.
The specimens were fixed in Carnoy's fluid (absolute ethanol + chloroform + glacial acetic acid 6:3:1) for 6 hours. The samples were then dehydrated, embedded in paraffin in a vacuum oven at 58°C, and sections of 5 μm were placed on gelatine-coated microscope slides The CA isozymes were immunostained by the biotin-streptavidin complex method, employing the following steps: (a) pre-treatment of the sections with undiluted cow colostral whey (Biotop Oy, Oulu, Finland) for 30 min and rinsing in phosphate-buffered saline (PBS), (b) incubation for 1 hr with primary antibodies diluted 1:100 in 1% bovine serum albumin -PBS (BSA-PBS), (c) incubation for 1 hr with biotinylated goat anti-rabbit IgG (Zymed laboratories inc., South San Fransisco, CA) diluted 1:300 in 1% BSA-PBS, (d) incubation for 30 min with streptavidin-horseradish peroxidase (HRP) conjugate (Zymed laboratories) diluted 1:750 in PBS and (e) incubation for 2 min in DAB solution containing 4,5 mg 3,3'-diaminobenzidine tetrahydrochloride (Fluka, Buchs, Switzerland) in 7,5 ml PBS + 2,5 μl 30% H2O2. The sections were washed three times for 10 min in PBS after incubation steps b and c, and four times for 5 min in PBS after step d. All the incubations and washings were carried out at room temperature. The sections were finally mounted in Neo-Mount (Merck, Darmstadt, Germany). The stained sections were examined and photographed with Zeiss Axioskop 40 microscope (Carl Zeiss, Göttingen, Germany). The intensity of immunostaining was scored on a scale of 0 to 3 as follows: 0, no reaction; 1, weak reaction; 2, moderate reaction; 3, strong reaction.
Results and discussion
Carbonic anhydrase XIII is a recently discovered enzyme, which is expressed in a number of different mammalian tissues. Structural modelling revealed that it is most closely related to cytosolic isozymes, CA I, II, and III with about 60% sequence identity, and therefore, this isozyme was clustered to the group of cytosolic/intracellular isoforms. Even though the previous paper described the distribution of CA XIII in several normal tissues, no data has been published to date on its expression in neoplastic tissues. To get a better insight into the changes in the expression levels that occur during the development of neoplasia, we analyzed both normal and pathological colorectal specimens from the same individuals.
Previous studies have indicated that CA IX and XII are overexpressed in certain tumors, including colorectal adenomas and carcinomas [18, 23]. They have been functionally linked to extracellular acidification in tumors that appears to regulate the invasive behaviour of tumor cells. Consequently, expression of CA IX has been associated with poor prognosis of some malignancies [19, 20, 25, 26]. Based on the present and previous results [23], cytosolic isozymes I, II, and XIII do not probably play a significant role in the regulation of pH in tumors. Instead, they may be important factors for the normal intestinal physiology. This suggestion raises an important question why at least three cytosolic isozymes are expressed in the normal colorectal mucosa. Even though we cannot answer to this question at this stage, it is of interest that these CAs represent isoforms with different kinetic or inhibitory properties. CA II exhibits the highest and CA I and CA XIII moderate carbon dioxide hydratase activities [2]. Because of different biochemical characteristics, it is unlikely that all these isozymes could contribute to the same pH regulation process. If this was the case, one could suggest that the enzymes with low or moderate activities should represent some sort of "junk" proteins in the proteome. However, there are other possible explanations which could be considered more sound in a biological system. First, several CA isozymes have emerged during evolution, because CA enzymatic activity is required for very fundamental reactions in the body. If one isozyme was functionally defective, the others could compensate the missing one. These compensatory mechanisms would partly explain why different CA deficiencies typically produce no or only mild phenotypic changes [27–29].
Another possible role of cytosolic CAs could be linked to a hypothetical tumor suppressor function. It is notable that CA1, CA2 and CA13 genes are closely linked locating in the q arm of chromosome 8. Simultaneous loss of expression could result from a deletion or point mutations within regulatory regions or alleles specifying these genes. The down-regulation could also result from reduced levels of a common transcription factor. Regardless of the mechanism, three cytosolic CA isozymes are affected in colorectal tumors, and it would be tempting to propose that normal CA I, II and/or XIII proteins could have a tumor suppressor function in epithelial cells, and deletion of those alleles could be an important factor in the cascade of events contributing to colorectal carcinogenesis. Even though colorectal cancer has been associated with gain of chromosome 8q in a number of previous studies, and no losses have been reported [30–33], there is some evidence that 8q21 contains a yet unidentified tumor suppressor gene [34, 35]. However, larger sets of tumors will be required to define explicitly, whether these CA genes are involved in genetic alterations of colorectal tumors.
CA XIII expression was clearly decreased in colorectal tumors compared to the normal tissue in a pattern similar to CA I and II. Loss of expression of closely linked CA1, CA2 and CA13 genes may result from reduced levels of a transcription factor or loss of alleles specifying these genes.
This work was supported by grants from Sigrid Juselius Foundation and Academy of Finland (200969).
Authors' Affiliations
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Pre-publication history
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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The bad blood still runs deep ... Ex-N.W.A manager Jerry Heller tells TMZ it was a slap in the face to Eazy-E to shut his son out of the audition process for the upcoming movie.
Jerry was leaving Craig's restaurant in West Hollywood Saturday night ... when he acknowledged the bad blood between Dre and Eazy and suggested it might have something to do with the fact that Lil Eazy was not even allowed to audition to play his dad in the flick.
Jerry clearly took sides on who was more important to the group -- Dre or Eazy.

subset: commoncrawl


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Based on the Journey to Freedom manual, this study guide is about learning to overcome fear and facing life with courage. Like the other study guides in the Journey to Freedom series, this study will help people change the things in their life that keep them from fulfilling their purpose and living their life to its fullest potential.
Other guides in the series include:
978-1-4185-0770-1 The Journey to a Life of Significance: Freedom from Low Self Esteem 978-1-4185-0771-8 The Journey to a New Beginning After Loss: Freedom from the Pain of Grief and Disappointment978-1-4185-0769-5 The Journey to Healthy Living: Freedom from Body Image and Food Issues


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We went on holiday to Devon to the farm, where we went last year. We had a lovely time again though it wasn't quite as sunny as last year!
We were meant to be going on the Friday but Mummy was ill and in bed most of the day so we went on Saturday instead which wasn't so bad. In the morning before we left I had a couple of early Birthday presents which were A bead bag full of nice beady craft,a Revell Train modeling kit and a very, VERY big Piggy bank!
When we got there we unpacked and set up our tent (the girls and I get the tent while Mummy and Daddy get the cottage as it only has two bedrooms!) Then we played with Jake, Annie and Jasper (the dogs!) and then we fed the horse Scarlet, when we got back we discovered that two home educated children were in the cottage next door which was great!
This is Jake doing his favourite hobby duck herding!!!
The first night we were there the white duck had ducklings and we were very happy for her because last year her duckling died but this year she had 7 but two of them died sadly but she still had 5.
We climbed quite a few hills including our favourite which I think is called Kestor? We played this game with our Dad where we split into two teams and we had to catch each other, it was fun until Daddy hurt his ankle and we had to go back to the cottage. We also climbed a very steep one but I have forgotten it's name but the moment we got to the top it started raining so we decided to go back down again!
Me again at Kestor.
We also went to Lustliegh Cleave which was by a stream and we met these people who were counting butterflies and we saw a Tiger Butterfly which was very pretty.
We also went to on of our favourite places, Belevoir. Where we hopped along the rocks for a while 🙂
And we went to a beach town.
And then we had fish and chips!
And then we went to the beach!!!!!!!!
We had a lovely week and we're going back again in August!!!!!!!


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Submitted photo
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ASTORIA — Lewis and Clark National Historical Park needs you to help discover living organisms at a BioBlitz quest and Biodiversity Festival on Friday and Saturday, May 20 and 21.
Volunteers of all ages are invited to join park rangers and scientists as part of a national effort to document and celebrate biodiversity in national parks. Lewis and Clark National Historical Park is one of 34 national sites in the Pacific West Region participating in the event.
At BioBlitz, participants will explore and help keep an inventory of pollinators, plants and more at the park. Attendees will identify and count plant and animal species using apps such iNaturalist, Bumble Bee Watch, Project Budburst and eBird. Visitors are welcome to bring their own technology or use a limited number of park devices.
Sign up is required to participate in scientist-led species inventories. Limited spots are available at Eventbrite to get on an inventory team led by an expert.
National parks are living laboratories for scientific investigations that continue to advance our understanding of nature. Parks often serve as indicators of the health of the world's ecosystems, and they are places to explore the natural world. You never know what's hiding under a rock or beneath a fern.
Leading up to the two days of BioBlitz activities is a Thursday, May 19 Nature Matters presentation by Rich Hatfield titled "The Iconic Bumble Bee: The Decline of Our Native Pollinators." Hatfield, a senior conservation biologist with the Xerces Society, describes the work being done to help conserve these pollinators and what you can do to help. The free event takes place at 7 p.m. at the Fort George Lovell Showroom.
The next night, Friday, May 20, learn about moths and night pollinators from 8 to 10 p.m. at the Netul Landing Shelter. Attend a presentation and moth inventory led by local experts, where you'll learn how to entice and identify these exciting night-time pollinators. Sign-up is not required.
Saturday morning, local biologist and educator Mike Patterson will offer a Sunrise Big Day Bird Count from 6 to 9 a.m. While Paterson is best known for his work with birds, he also possesses extensive knowledge of invertebrates and other organisms and has a keen interest in the interconnections of living things. After a brief discussion and gathering, divide into smaller teams and set out looking for birds along the Lewis and Clark River. Dress for the weather with closed-toed shoes, and bring water, snacks and binoculars. The count is wheelchair accessible. No pets are allowed. Sign up now at Eventbrite or just show up at Netul Landing.
Species inventories events are planned for Saturday, including multiple inventories for you to participate in and become a citizen scientist. Join experts and learn to identify butterflies, dragonflies and pollinators. Then share your findings with the world via iNaturalist. Dress for rain or shine, wear closed-toed shoes, and bring sunscreen, insect repellent, water, snack and/or lunch, and your smartphone. No pets are allowed. Preregistration is required; sign up at Eventbrite for the following sessions; only about 12 slots are available for each session:
• 10:30 a.m. to 12:30 p.m. – "Pollinator Inventories" led by Patterson, biologist and educator.
• 11:30 a.m. to 12:30 p.m. – "Dragonfly Inventory" led by Jim Johnson, a dragonfly expert and enthusiast who serves on the Dragonfly Society of the Americas executive council.
• 11:30 a.m. to 12:30 p.m. – "Butterfly Inventory" led by Candace Fallon, a conservation biologist at the Xerces Society, where she works to better understand and protect invertebrates and their habitats.
• 11:30 a.m. to 12:30 p.m. – "Butterfly Inventory" led by Robert Pyle, a butterfly ecologist and founder of the Xerces Society. Pyle has a Ph.D in butterfly ecology and has been involved in butterfly science and conservation for more than 50 years.
• 1:30 to 2:30 p.m. – "Butterfly Inventory" led by Fallon.
• 1:30 to 2:30 p.m. – "Butterfly Inventory" led by Pyle.
A Biodiversity Festival is also taking place from 10 a.m. to 3 p.m. Saturday, featuring a slate of activities and talks at Science Central, the park's Netul Landing complex. The schedule is as follows:
• 10 to 10:30 a.m. – The day will begin with "Why Biodiversity?" by keynote speaker Jerry Freilich, who is the retired director of the North Coast & North Cascades Science Learning Network.
• 11 to 11:30 a.m. – "Dragonflies of Clatsop County" by Johnson
• Noon to 12:30 p.m. – "Biodiversity Begins with a Bee" by Jerry Freilich.
• 1 to 1:30 p.m. – "Butterflies of the Maritime" by Pyle and Fallon.
• 10 a.m. to 3 p.m. – Cultural Demonstration by the Chinook Indian Nation. Meet artist and carver Tony Johnson, the current chair of the Chinook Indian Nation and a scholar of language and culture. Johnson acquired Chinuk Wawa as a second language and wood working skills from his elders. He is now teaching the next generation.
• 10 a.m. to 3 p.m. – KidZone calling all kids: Join park ranger staff and volunteers for a little creativity and nature-inspired crafts or just have your face painted with favorite bird, invertebrate or plant.
• 10 a.m. to 3 p.m. – Other fun: Help upload findings to iNaturalist. Check out what is happening at the other Bioblitz activities across the nation on the big screen. Look at some of the day's findings under microscopes. Chat with experts and learn more about the environment around us.
• 2:30 to 3 p.m. – Thank You from Lewis and Clark National Historical Park Superintendent Scott Tucker.
All events will take place at the park's Netul Landing Complex and are free.
Preregistration information and the Saturday schedule is available at the park's website, www.nps.gov/lewi and Facebook Page, or can be picked up at the Fort Clatsop Visitor Center front desk. For more information, call the park at 503-861-2471.


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While card tricks are a staple with many magicians out there, spectators want more than card tricks. However, when you need more than a stereotypical card trick, try picking up an everyday object like a gum pack and let Tom Elderfield show you how you can turn that ordinary pack of gum into a carnival of gum magic.
On this DVD you're going to learn a bounty of original gum tricks that Tom uses every day to astound and inspire. He'll teach you how to shift the flavor of your gum from watermelon, to blueberry, then to strawberry.
CLICK HERE for more info!!
First came "Inferno," which won Trick of the Year in 2012. Then came "Out of Sight," which fooled Penn & Teller. After eight years of development, performed exclusively at the end of Joshua Jay's parlor shows, he is ready to unveil a sensational, unique wonder... AND SAVE if you buy early because the retail price goes up $50 on January 1st, 2019.
Balance features the rarest effect in magic: suspension. An eclectic but ordinary group of objects is passed out for close examination: a bottle, a card box, a pencil, a toothbrush, and a crayon box.
CLICK HERE for more info!!
The same high quality VDF close up pad but with a detail which makes it even more interesting: printed with four aces, one at each corner.
Composed of two layers: non-slip rubber under, and soft fabric above. High quality at an unbeatable price.
- Does not slip.
- Does not tear.
CLICK HERE for more info!!
Three guys go out for lunch. They pay. Yet each time they count their change, there is a missing dollar bill. So, they try it again. Another dollar is found missing. Each time they count the total dollars, one always goes missing.
Nick Einhorn (winner of Penn & Teller: Fool Us) breathes life into a classic riddle that you have to see to believe. Count the dollars, one is missing. Count again, there goes another.
It's a smashingly fun puzzle that you will show at dinner parties and gatherings, where they will scratch their heads in disbelief.
CLICK HERE for more info!!
FOB is the perfect finale to you're existing card and mentalism routines.
A folded card is isolated inside a clear key FOB that never leaves the spectator's sight. At the conclusion of your favourite card routine the card is cleanly removed from the FOB and it turns out to be their signed selection.
FOB can also be used with bills, billets, photographs, in fact any item that can fit inside the FOB.
FOB may look innocent but in fact this is a precision made gimmick that allows you to ISOLATE THE IMPOSSIBLE
"This is just BEAUTIFUL!"
- Shawn Farquhar - FISM World Champion
"That is F*****G AMAZING! I will keep this on me 24/7.
CLICK HERE for more info!!
'What is Pipmen?'
Pips are the suit symbols on the card face - the spade, heart, diamond, or club indicators. In addition to this standard element, each Pipmen card has little stickmen figures interacting with the pips to create a unique scene. So Pipmen is the Pip-men! Get it?
- Gorgeous wraparound box art
- Thick luxurious paper stock
- Printed by MPC
- World's first 52-piece self-contained Polyptych puzzle
What sets this project apart from every other deck on the planet? What makes this a totally unique, world-first, revolutionary creation unlike anything else ever? First of all, it's beautiful!
- 4885 different design layers
- 150 individual Pipmen
- 54 unique cards
- 32 months of design time
- 16 different terrains
- 6 UFOs
- 5 Eagles
- 4 Skeletons
- 3 Cows
- 2 Rockets
- 1 Pipmen World
This deck is absolutely unique because while every single card is a fun, little self-contained scene, they all fit together into one big picture - the Pipmen world!
There have been a few other decks that have had a composite feature, but Pipmen World stands alone.
CLICK HERE for more info!!
"Swap" in three words: PRACTICAL, ORIGINAL, STUNNING.
Nicholas Lawrence releases his "pet" pocket effect, which he does every day to amaze the people in his life. The effect is this: you reach into your pocket and remove a dollar bill and clearly show it. Now you VISUALLY move the printed seal around on the bill and cause it VISIBLY change places with another insignia. You can then hand out the bills and nothing suspicious can be found.
Moving printed material on bills is not new, but the startling nature of causing two symbols to change places IS new, and it makes for a moment your spectators will never, ever forget.
CLICK HERE for more info!!
Now it's your opportune moment to take a vacation. Though we can't share the trip with you, we hope you can share this wonderful time with our new deck. Cardistry Color Playing Cards is COMING!
The interplay of bright colors plays an important role in the design. Radiant yellow, fun pink and light blue colors produce a stunning visual effect. The card back follows the first edition design. The geometric element is always the most important.
The design for the custom card faces is a perfect combination of classic and modern.
CLICK HERE for more info!!
Predict their dream vacation!
This is a triple prediction with an emotional twist. Your spectator really does go on a journey in their mind and you have correctly predicted all the elements of it!
Luca Volpe explains his original take on a classic method in mentalism. A mixture of four different concepts that are blended together to create an impossible and stunning mind reading routine.
Once you discover the methods involved in this routine a new world of possibilities will open up! The props required are very easy to find and the routine can be performed in any kind of situation.
CLICK HERE for more info!!
Shin Lim, 2015 FISM World Champion in Close-up Card Magic is known for using music to move his audience instead of words, creating an unique and powerful experience. Now he has done the same for custom cards with his new deck.
- Red foil embossed tuck box
- Crisp black and red contrasting colors
- Amazing feel and control
- Subtle balance of patterns, straight lines and curves creating a mesmerizing effect.
- Designed by Nick Vlow
- Produced by Shin Lim
See why Shin Lim uses these cards daily.
CLICK HERE for more info!!
Never has there been a more articulate manifesto declaring magic a true art. And never has one man offered a more detailed and coherent plan for achieving art by the practice of magic.
Through a series of tricks, routines and essays, Tommy Wonder provides a clear blueprint for an uncompromising brand of magical theater. Along the way he explains his professional routines for Close-up. Stand-up, Walk-around and Stage.
Among them are...The Updated Two Cup Routine; Watch in Nest of Boxes, 3 methods; Wild Card Tamed; The Watch, the Ring & the Wallet; The Well-tempered Birdcage; and 50 other card tricks, routines and sleights.
CLICK HERE for more info!!
Hook your spectators from the very start with the most visual and surprising way to start a magic trick! Turn a pencil into a Sharpie, instantly!
From the creators of Bare, Hands Down and SNAPPED, Maxwell's Signature Opener adds a new and surprising way to begin a magic trick. From those just beginning their journey into magic to the most experienced magicians, Maxwell's Signature Opener is a great addition to routines for magicians of all ages and experience levels.
CLICK HERE for more info!!
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Appleis Senior Vice President of Worldwide Product Marketing profited more than US$2.3 million as he cashed in on stock options February 4, according to calculations by The Mac Observer from ownership statements filed with the US Securities and Exchange Commission.
Phil Schiller sold over 75,000 shares in the stock, which he purchased at $47.43 per share. All the shares were sold for between $78.18 and $78.46 a share.
In total, Mr. Schiller profited $2,313,828.30.
Five other Apple execs sold shares in recent weeks, as first reported by The Mac Observer on January 28. The transactions totaled in excess of $65.5 million.
Apple (AAPL) stock hit a new all-time high Tuesday of $80.90.


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Sta-Rite Anthony Set Screw - U30-754ss
No.5 Image Shown AboveU30-754SSAnthony Sta Rite Set Screw Used on Anthony Products Manufactured By Sta-Rite Pool Pump PartsAnthony is made by Sta-Rite is a common name in poolpump parts. The schematic diagram of pump parts, Anthony pool pump parts,Anthony - Sta-Rite Products, Anthonypump parts and spares (spare pump parts) are listed. Always low prices and fast shipping. DiscountAnthony CFA / CF6, Anthony Bronze Centrifugal Pump and Anthony Antho-SweepBooster Pump parts and other swimming poolpump parts are always in stock and available.Back To Anthony Bronze CFA / CF6 PartsBack To Sta-Rite CF6 & CFA Series
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Join the Nation's Conversation
To find out more about Facebook commenting please read the Conversation Guidelines and FAQs
Senators fret over security of electric grid
WASHINGTON – The inspector general of the Energy Department declared late Wednesday that leaked information about electric grid vulnerability should have been worthy of "classified" status, leaving some senators concerned that national security may be at risk.
"This revelation, with its national security implications, is extremely troubling," said Sen. Lisa Murkowski, R-Alaska, ranking member on the Senate Energy and National Resources Committee.
Last month, the Wall Street Journal published information from government briefing papers describing vulnerabilities in the nation's electric grid. The briefings were in response to a 2013 sniper attack on a California substation, which was first publicly reported in February.
At the hearing Thursday, senators said they were concerned because the material included the identity of specific, critically important substations across North America. The Journal did not include the names of the stations in its article.
The committee's hearing was originally scheduled to discuss improving security of the grid, but the inspector general's announcement dominated the conversation.
The substations were first identified in briefings by the Federal Energy Regulatory Commission after the California attack. Federal agencies, trade groups and private industry were in attendance at the briefings.
Parts of the briefings were subject to non-disclosure agreements, according to the commission.
In the hearing, senators chastised the media and the commission for the leak and asked about actions being taken to prevent similar disclosures in the future.
"I continue to believe that publication of such information about the grid undermines its security," said Murkowski.
"We are working to fully understand what happened and what we can do to improve our internal processes to ensure that no similar disclosure will occur in the future," said Cheryl LaFleur, acting chairwoman of the energy commission.
LaFleur would not speculate on the identity of the leaker. She said she had no reason to believe that criminal charges would be levied.
Her predecessor, former FERC Chairman Jon Wellinghoff, said in an interview that the inspector general's ruling and ensuing controversy were "nonsensical," pointing out that the commission's information simply confirmed previous government studies and analyses, some of which were public.
"Let's not worry about whether something's classified or not classified or leaked or not leaked," Wellinghoff said. "The real point is we need to protect these facilities and protect them as quickly as possible."


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Yes i see that cages in our minds are bad.....But if we really think about it farmers can have more chickens in there barns if they have cages more chickens more food and ore profit for the farmers and look at the pictures of the farms with no cages and with cages whats the difference? They are just about the same but with the cages they can't fight or hurt each other.
I know that a hen needs eight hours of sunlight, eight grams of protein and about two cups of water to produce one healthy egg. Battery cages don't supply the hens to fulfill these needs. The ovulation process takes about twenty eight hours. If a hen is stressed, she won't produce healthy eggs. Being crammed in a small cage with an inadequate supply of feed and water is very stressful. Also the hens never get to roam and stretch their wings. This can lead to pigeon-toe, splayed legs, broken wings and many other injuries and stress-induced disorders. Besides being very inhumane, battery-caged hens also produce unhealthy eggs. Stress can effect the quality of the egg, the shell becomes brittle and breaks. Then the eggs have to be cleaned. Many egg industries use bleach and chemicals to clean the egg shells. Eggs have pores and the chemicals can flow into the membrane and contaminate the amniotic fluid and yolk. Also, the hens are fed hormones to increase egg production. Studies show that these hormones are linked to obesity and heart problems in the consumer. The confined room in the cages promotes the spreading of disease. This causes salmonella and E-collie outbreaks. Don't support battery caged hens. Support your local farm, raise your own live stock or go vegan. If you raise your own livestock, you know what is going into your hens and the quality that will come out. If you go vegan you can still obtain protein from plant sources. But of course, you can chose to support disease-infested hen death chambers known as battery cages and egg industries.
In fact, people need to realize what it takes to raise 2-3 chickens. It is not difficult, they produce organic manure and control bugs, if let to run free. If in a mobile chicken tractor, they get fresh grass, your lawn gets fertilized and the pest population is reduced. Not to mention eggs.
If half of America raise a couple chickens, we could eliminate the entire factory egg production market. That's rights, no factory chicken farms, no need to cage them or even have this conversation.
In the words of Earl Pitts, wake up America. Raise your own chickens. I have 15 people covered with my 30 chickens.
Chickens are animals. Animals are capable of feeling claustrophobic and being in pain. Therefore, raising them in small cages to cut costs is inhumane and should be illegal. It's just not right to put a small chicken in an even smaller cage. Plus, the eggs that the chickens produce are of a lesser quality than free range chickens.
No I do not think it is okay to raise chickens in small cages. It is cruel and just because we use that type of animal for a food source does not mean it is right to treat their life like it is worthless. All living creatures should be given a certain standard of living.


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Purchases over $1000 qualify for 6 months no interest financing. Purchases over $3000 qualify for 12 months interest free financing. Contact us for details.
We offer extended test rides on selected bikes. Reserve online.


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I am a Harry Potter fan, but I have never considered myself a J.K. Rowling fan. I'll only say I love an author if I've read multiple works and enjoyed the majority of them. Until a few years ago, that wasn't an option with Rowling.
When The Casual Vacancy came out in 2013, a lot of Harry Potter fans jumped for it, even as critics said, "It's very different."
I knew that, but I wanted to give her a chance as an author, to see if I liked her and not just this one world she'd created, so I knew I would read it eventually. Now that I have, I've got to say…I'm still not a fan.
After my experience with Harry Potter and the Sorcerer's Stone, I expected the story to have a slow start. I gave it time, but I was 80% through the book before I reached a spot where all I wanted to do was read. It's all about a small town full of miserable people making each other miserable.
She tells it from multiple perspectives in order to humanize every character, but it instead gave me the impression that each of the adults was self-absorbed and didn't care what damage they were causing, even to their own kids.
For the most part, the kids aren't much better. (Though with these people raising them, how could they be?) I don't have a problem with unlikable characters, but if you're asking us to read 500 pages about them, they should at least be compelling. The only one I rooted for, the one I kept reading for, was Krystal Wheedon. And instead of being treated like a character, she often acted as a plot device and catalyst for events around her. This was so much the case that some of her actions towards the end, while not completely out-of-character, felt like a stretch. And the ending!
I have reached a point in my life where I under the place tragedy has in literature. Even character death, as Rowling herself demonstrated beautifully in Harry Potter, can be important in a narrative. The Casual Vacancy begins with a death that sets every other event into motion, which makes sense and works well as an opening. But it also ends with death, and this was the one I had a problem with. Instead of focusing on the tragedy itself, Rowling shows us the effect it has on every other character. That made me angry.
Many of the families were brought closer in the wake of it. Where the first death started a war, this one enacted a ceasefire. It's not because they are comforting each other, but seems to be out of shock. It is a fragile peace; they are all still miserable, but different miserable, or else they've just gone back to taking it quietly. I was left with the impression that the death would not have a lasting impact on many of them.
It took me over a month to read this book and some spots were especially hard to read because of how heavy they were. There are books like that I would recommend, but The Casual Vacancy isn't one of them. There are a few pretty lines, but there is not emotional payoff in the end; it's just not worth the struggle.


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Brief overview will include: recent changes to Medicaid, Family Health Plus
and Child Health Plus; Medicaid managed care for SSI recipients; transitioning
to Medicare.
Date of original presentation: 12/04/2009
Presenters: Cathy Roberts, Empire Justice Center, Albany, NY; Catherine Callery, Esq., Empire Justice Center, Albany, NY
Viewing time: 1 hour 49 minutes
CLE credits: 2.0 Professional Practice
Cost for viewing this training if CLE credit is requested: $60.00 for Not-for-Profit Agencies; $90.00 for Private Practice Attorneys. There is no charge for viewing this training unless CLE credit is requested.
Financial Hardship Policy available upon request. Contact Michelle Peterson, Training Coordinator
Newly admitted attorneys in New York State can not receive CLE credit for online training.
If you are an attorney who is not licensed in New York State and want CLE credit, please check to see if your state allows New York State CLE credits to be applied to your state's CLE requirements.


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Central CT, Danbury, Hartford/East Hartford, New Haven, Norwalk, Stamford and Thames River Advance to Final Stage of Process
Rocky Hill, Conn. – April 25, 2017 – CTNext, Connecticut's go-to resource for entrepreneurial support, today announced the finalists for Implementation Grants as part of the Innovation Places program. Innovation Places is a CTNext-run program created to enable communities across the state to become top-tier destinations and magnets for talent and high growth companies. It will create a concentration of entrepreneurs, innovators, tech talent, support organizations and research institutions that come together in dense, walk-able, transit-connected communities.
The program will distribute $30 million to the winning cities and communities over a period of five years to support catalytic projects to stimulate their local innovation ecosystem. A portion of the $30 million has been reserved for the first set of winners with future allocations to be determined by the CTNext board of directors at a later time. CTNext received applications from 12 communities across the state and, following a comprehensive review, the CTNext board of directors has selected the following for advancement to the final stages of the process:
- Central CT (New Britain, Farmington, Berlin)
- Danbury
- Hartford/East Hartford
- New Haven
- Norwalk
- Stamford
- Thames River
"From our bigger cities to our smaller communities, each application we received was comprehensive and impressive, reflecting the drive among our local leaders to more deeply establish Connecticut as a hub for entrepreneurism and business growth," said Glendowlyn Thames, executive director of CTNext. "So much excitement, engagement and creative thinking came from all 12 participating communities. As we move ahead in the process, we look forward to visiting with each finalist to learn more about their vision and plans for making their local community an Innovation Place."
Over the next two weeks, the CTNext Board of Directors will conduct site visits with each of the finalists to view the Impact Areas outlined in each strategic plan. A complete schedule of finalist site visits and public pitches will be available on the CTNext website on Thursday, April 27.
Grant winners will be announced in June.
About CTNext
CTNext is Connecticut's go-to resource for entrepreneurial support. The goal of the program is to build a more robust community of entrepreneurs and to accelerate startup growth by providing access to talent, space, industry expertise, services, skill development and capital to foster innovation and create jobs for people in Connecticut. CTNext launched in 2012 and has more than 1,700 members in its network. Visit www.ctnext.com for more information.
Media Contact:
Greg Kalish


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A Hollywood woman was arrested Monday after she led police on a 90 mph chase that ended when she slammed into a Dania police car, police said.
No one was seriously injured, but one of two Dania police officers was shaken up after Susan Finsterer's 1979 Pontiac Sunbird hit their squad car in the 1200 block of South Federal Highway, according to Dania police.
The chase began in Fort Lauderdale shortly after midnight when police were dispatched to the 1800 block of South Federal Highway and found Finsterer standing next to her car, police said.
Officer David L. Jenkins told Finsterer she was too drunk to drive and advised her to call a taxi. Finsterer said she would call a friend.
But when Jenkins turned away from her she slipped behind the wheel of her car and took off, police said.
As she sped south towards Dania, a Fort Lauderdale police car managed to pull alongside Finsterer, but she swerved and forced it off the road, police said.
In Dania, Finsterer veered into the wrong lane and narrowly missed hitting a truck head-on before crashing into the police cruiser, police said.
Fort Lauderdale police charged Finsterer, 28, with aggravated assault, driving while intoxicated, resisting arrest without violence, possession of marijuana, battery and reckless driving.
Finsterer, who lives in the 6300 block of Fillmore Street, also was charged by Dania police with two counts of aggravated battery and reckless driving, police said.


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FIM-E Main Event, Santa Pod Raceway
TV Show:
The FIM-E European Drag Racing season had its traditional opener over the Whit Bank Holiday at Santa Pod Raceway, with hot conditions for much of the qualifying days, before cooler and eventually very damp conditions curtailed eliminations before the semi-finals were completed. Whilst the rain ended the fun in the four FIM-E drag bike classes, the event seeing a number of new combinations, class hopping and the championship stalwarts joined by a whole host of new faces. Despite the early finish, hopefully the growth in entries will continue as a theme for the rest of the year.
FIM-E Top Fuel Bike
With 10 time and reigning champion Ian King racing in the States in 2017, the chase for this season's title in the premier FIM-E Top Fuel Bike category seemed to be wide open, and, with the early finish to the meeting, we are little the wiser. Low qualifier with an off the trailer 6.114/220.17mph, Rikard Gustafsson on the RG Engineering Puma fueler had made some small adjustments over the winter, with a new stronger crank being foremost among these. With 11 entries, Gustafsson had a healthy half a second advantage over the field, the best of the rest being Greece's Fil Papafilipou on his nitrous PXM at 6.687/205.34. It seemed as if raceday would be plain sailing for the Swedish team were worried about some main bearing damage on the new crank, skipping the final qualifying session and having a late night polishing it back into race ready condition.
First to line up in eliminations were Rene van den Berg and Stuart Crane in the of four nitrobike v funnybike that were a signature of the opening round, this one went to van den Berg (who had windowed a block in qualifying) in a 6.543/194.70 to 6.973/172.36. Steve Woollatt on the Dealer PBR Puma fuel bike prevailed over Papafilippou with a 6.450/192.44 and Otto Knebl made it three out of three for the nitrobikes with a mid-seven second. victory over the unique compound turbo entry of Lorcan Parnell. And so to the Swedish head-to-head. Pettersson put his qualifying woes behind him and left the line first and was still neck and neck at half-track, but the funnybike was heading for the centreline causing an early shutoff and Gustafsson passed him to record a 6.435/233.70.
The semi-finalists were in the pairing lanes when the rain came down, but Gustafsson was without his bike as a plummet in oil pressure as he rolled off the throttle suggesting the main bearing had given up the ghost again: "I'll have a look at it when I get back home, but it might mean I have to buy another crank and they take a long time to be delivered". Hopefully the outcome won't mean that Rikard has to skip a number of meetings and that he remains a strong challenger for the championship (and his own personal goal of a five second pass after coming so close last year).
FIM-E Super Twin Bike
Super Twin had a number of withdrawals after explosive incidents in qualifying, with Ronny Aasen barely getting off the line before the bottom end failed on Ton & Vincent Pels' supercharged Zodiac entry, Petr Ceska blowing his only motor on a slowing eight second pass and class rookie (but reigning Pro Stock Bike champion) Gert-jan Laseur torching a head on his final qualifying effort. Laseur's Dutch compatriot Martijn de Haas qualified low with a 6.878/199.76 closely followed by Czech star Roman Sixta on a 6.891/206.12, with French debutant Bruno Salesse getting a handle on the ex-Job Heezen and ex-Lo Stauble championship winning ride. In the only round of eliminations, Sixta defeated Salesse with a seven zero, whilst de Haas rode out a shaking launch to set class low ET with a 6.721/206.03.
FIM-E Pro Stock Bike
The Stockers had a bumper twelve entries trying to make the cut, with Ålund's Fredrik Fredlund taking it cautiously on his currently unsponsored Suzuki but still ending up on top with a 7.031/189.00, with Swede Kenneth Holmberg bouncing back from a broken connecting rod wiping out his primary engine in the first qualifying session to end up in 3rd with a 7.289/179.16 to sit just behind French rookie Charly Abraham's 7.286/171.73 on his first event in the seat of the ex-Laseur Buell. Again, only one round of eliminations was completed, with Fredlund progressing past Denmark's Fredrik Schack's 7.621/169.18 with a 7.062/188.13. Alex Hope defeated Martin Newbury in an all British match up, whilst the other qualified Brits Martin Bishop and Len Paget fell to Holmberg and Abraham respectively.
FIM-E Super Street Bike
So long a British benefit, with Garry Bowe (7.061/207.04) and Rick Stubbins (7.097/203.23) flying the flag for the UK in the top spots in qualifying, the Super Street Bike class is now a truly Pan-European one with a dramatic increase in the Scandinavian entries this year. The sixteen bike eliminator almost managed to complete two rounds with Hungary's Daniel Donat Lencses defeating Bowe, Stubbins progressing past Steve Venables and a surprising Dave Thomas (having repeatedly lowered his PB mark to just make the field) who holeshot incoming points leader Malta's Franklyn Borg to book a space in the semi-finals. Unfortunately repeated holds for drizzle bumped the final pairing behind the Pro Mod quarters which delivered further frustration in the shape of an oildown, leaving Dane Mogens Lund and Swede Robert Nilsson in the water box muttering more than a few Scandinavian oaths when the rain came.
Remaining FIM-E 2017 Championship dates
18th – 20th August NitrOlympX, Hockenheimring, Germany
7th – 10th September Euro Finals, Santa Pod Raceway, UK
View points standings on the Points page.
Words and bike pictures Ivan Sansom and Rose Hughes.
Thanks to TSI Timers (Europe) for access to the timing data.


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The Marston's Single Hop Goldings is the latest in their single hop range, previously I tried one as part of my Jubilee Beers series and it was very good, hopefully this beer is just as impressive.
Single hop beers are often quite interesting, which seems contrary as they are minimised in the materials available to the brewer. They do however showcase the flavours of a single hop which means that for those interested in what flavours each hop brings to the beer single hop beers hold their own interest.
Goldings is a hop associated with British ales and usually imparts a slight spiciness to the beer. It is normally used as an aroma hop and used with other hops to define a beers character so to taste it on it's own is interesting.
The nose is slight caramel and citrus bit very weak, the initial taste is unmistakeably goldings hops a slight citrus flavour. The middle is a nice caramel maltyness with a sweet honey like flavour. The end is more goldings hop flavours grassy and slight spiciness.
The decision to brew a beer with a traditional malty honey middle to compliment and back up the goldings hops is a good one. The beer is uncomplicated but that is to be expected from a single hop beer, but the flavour is clean and pleasant. At 4% and with no detracting after-tastes Marston's Single Hop Goldings is a real sessonable beer, sadly I think it will be unlikely that I will get the chance to try this beer on tap and really give it a good try as a session beer – but if any brewers are reading this then try this beer as an example of what I would like to have in a session beer.
Marston's Single Hop Goldings is currently available in supermarkets as with the other single hop beers from Martson's it is a limited relase so get it while you can!


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Vacation in Hong Kong & Macau
In my earlier posting, I mentioned about the trip to Hong Kong and Macau during my recent relief break. It was a very tiring break for me having to unpack and pack within a week after touching down in Singapore and unpack and pack again after a week in Hong Kong for my return to Cairo. Nevertheless, it was a fruitful outing where I spend some good quality time with family. Here is the photo album on my vacation to share:


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How does an imprisoned man find the time to knock up four of the guards that were hired to watch him?
Apparently by corrupting them.
Maryland gang member, Tavon White, is accused of running a scheme to smuggle contraband into the prison by persuading 13 female prison guards from behind bars. But for four of those women, that persuasion included getting it in…and eventually getting pregnant.
A federal indictment says Tavon White has been charged in the plot to smuggle drugs, cell phones and other contraband into the Baltimore jail and other corrections facilities, along with the prison guards, six of his fellow inmates and five others with gang ties who allegedly operated outside the jails.White is accused of "corrupting" the female officers through personal and sexual relationships and other bribes. Eventually he convinced them to join his ring.
The indictment also says the ring involved sex between the inmates and guards, which led to four of the officers becoming pregnant by White, the leader of a jailhouse gang called the Black Guerrilla Family.
According to MyFoxDC:
The ring became increasingly brazen and confident over time, with White quoted as saying: "You understand me? This is my jail. I am dead serious, I make every final call in this jail."Who the hell does he think he is?
The gang members and the corrections officers have been charged with conspiracy, drug possession and distribution and money laundering.
So a criminal with no money, no freedom, and arguably no looks now has four children on the way and their mothers are all prison guards? This man is a hell of a persuader! SMH!


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I know that I sometimes whine about how thoroughly midwestern Grand Rapids can sometimes be. Yesterday morning I was once again beset by self-pity, feeling exiled in a cultural backwater, when I discovered that neither Waltz with Bashir nor Revolutionary Road were playing in a single cinema in the Grand Rapids area. (You must read, by the way, James Wood's stunning piece of criticism on Yates in the recent New Yorker.) Having lived in Los Angeles for a few years, I got used to movies being "open in select theaters" just meaning, "open in the theater around the corner." Turns out--surprise, surprise--that Grand Rapids was not "selected."
But also as per usual, my wannabe-Manhattanite, cold snobbishness was gradually thawed through the day. While reading and working at Common Ground, I grinned to myself when I noticed a fellow patron reading Saul Bellow's Herzog. This was then capped with a wonderful evening at one of my new favorite spaces in Grand Rapids: the "Literary Life" Bookstore at the corner of Wealthy & Eastern, within walking distance from my house.
Deanna and I finally "discovered" Literary Life before Christmas. While it's been on our radar, I'm embarrassed to say I never made it inside until just last month. What a wonderful literary oasis! I immediately ended up in a back corner of the store that was loaded with books to sustain a writing life, then migrated into a rich poetry section, and only teased myself with the fiction shelves that looked so different from the chain store offerings. All of this clearly demonstrated a staff that knows what matters in the world of literature, poetry, and writing.
And last night was the beginning of a new Literary Life tradition: "Third Thursdays" will feature local artists and writers in a casual venue, enjoying coffee and LitLife's fabulous selection of teas. (The Harney & Sons "Paris" blend found tastebuds I didn't know I had before.) The opening act was the Kilpatricks, a wife/husband duo whose acoustic sound was somewhere between folk and a kind of "blues." (Great covers of Belinda Carlisle and Leonard Cohen/Jeff Buckley's "Broken Hallelujah." I'd love to hear Amber cover Rosie Thomas.) While listening, and afterwards, we could browse the shelves and I was once again impressed: somehow I got locked in the Ws (oh yeah, I was looking for Yates) and found a trove of David Foster Wallace and Evelyn Waugh. Hallelujah, indeed.
In short, Literary Life helps me to imagine how one might sustain a "literary life" right here in Grand Rapids.
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The perfect addition to your arsenal!
The Planet Waves Pro-Winder is a must for your gig bag. It's a high-quality peg winder with slots for either guitar or bass pegs and a built-in string clipper. There's also a peg puller on one end for changing acoustic guitar strings without marring up your pegs with a needle nose pliers. The Pro-Winder enables you to change your strings with one single tool, and it's easy and comfortable to use! Seriously... we can't recommend this enough. This thing is awesome.
Heid Music is proud to be your resource for Planet Waves guitar accessories in Appleton, Green Bay, Madison, Oshkosh, Wisconsin Rapids, and online.
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The India-based owner of the Pierre Hotel wants to hop on the Orient Express — again.
Shares of Orient-Express Hotels, whose properties include Manhattan's 21 Club, surged 22.5 percent, to $11.05, yesterday after it got a buyout offer from Indian Hotels, which had tried unsuccessfully to acquire the company four years earlier.
The group, controlled by Indian billionaire Ratan Tata, is offering $1.42 billion, or $12.63 a share, for Orient-Express — a 40-percent premium to the day-earlier closing price.
Tata is making a second pass despite a rebuff that provoked a nasty dust-up the last time around when Orient-Express said being acquired by the Indian company would damage its brand.
This time Tata has brought on board former Orient-Express CEO Paul White, who resigned in July 2011 for personal reasons.
Tata also has cut a deal with former Orient-Express Chairman James Sherwood for certain purchasing rights to the company's Cipriani Hotel in Venice.
Despite the preparations, Tata must still win the approval of Orient-Express for its offer. In a filing yesterday, Indian Hotels, which owns a 6.9-percent stake, said it's taking its offer directly to shareholders after the failure of talks in August.
In 2008, Orient-Express had told Indian Hotels in a letter that its famous European railroad line, as well as its swanky hotels, including Rio de Janeiro's Copacabana Palace and Venice's Cipriani Hotel, would make a bad fit for "your predominantly domestic Indian hotel chain and our global portfolio."
The letter provoked cries of racism from India's media and business moguls.
Officials at Orient-Express, based in Bermuda, couldn't be reached for comment.


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Cash accounting scheme: Records and accounts: Receipted VAT invoices
The normal requirements concerning evidence for the deduction of input tax apply to businesses using the cash accounting scheme. VAT Regulations 65(3) and 65(4) also require users of the scheme to obtain particular evidence of payment.
65(3) A person operating the scheme shall obtain and keep for a period of 6 years, or such lesser period as the Commissioners may allow, a receipted and dated VAT invoice from any taxable person to whom he has made a payment in money in respect of a taxable supply, and in such circumstances a taxable person must on request provide such a receipted and dated VAT invoice.
65(4) A person operating the scheme shall keep for a period of 6 years, or such lesser period as the Commissioners may allow, a copy of any receipt which he gives under paragraph (3) above.
"Money" in this Regulation means banknotes or coins. If payment is made by cheque the VAT invoice does not need to be receipted.
The VAT invoice does not need to be separately receipted if the accompanying till receipt or similar receipt states "cash sale" or clearly indicates that cash has been given, for example through an analysis of change given. You should only question non-receipted cash purchase invoices where there is clearly no evidence of cash payment.


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I also got a very special gift.
About a week ago, my 7 year-old started talking about the gift she was making for me at school, ramping up the excitement and anticipation (aka anxiety) each day. Her comments started on Monday with a little grin and twinkling eyes saying, "I can't wait to give you your Mother's Day present." And by Friday, we had progressed to squeals and clapping and jumping from the furniture with declarations of, "You are going to LOVE your Mother's Day present! It's going to make you feel just like a princess!"
Oh. snap.
Cue heart palpitations and scaly fingers of dread constricting my throat. (Dramatic much?)
What in the world could she have made at school that would make me feel just like a princess? I had no idea. I mentioned it on Facebook and Twitter and the general consensus among my friends was that...
1.) I should, in fact, be very nervous about this gift.
2.) There was a strong likelihood that at some point on Mother's Day, I would end up in an adult-sized tutu. A tiara was not completely out of the question, either.
The one ray of hope I clung to was that surely an adult-sized tutu couldn't fit in her little backpack. Right? It couldn't, could it?! Please, God, don't let it fit in her backpack.
Looking back, there were a couple of hints that should have clued me in on this princess-inducing gift, but my muddled mommy brain didn't put it all together until afterwards. One was when she said, "Mom, have you ever had tea in a pouch?"
"Uh, not that I recall. Is that like a CapriSun or something?"
"Yeah, I guess. But I think you mix it with water first."
Hmmm. Tea in a pouch? That sounds as though it would make me feel like the exact opposite of a princess, but okay.
Well, Sunday finally arrived and I woke up to Corban's sweet, freckled face beaming with pride as she delivered this to my bedside table...
Breakfast in a Bag! And tea in a pouch! Turns out, I've completely failed Parenting 101 since my kid has never heard of a tea bag. My English friends are going to be so ashamed of me.
I have never felt closer to being royalty in all my life. I've also never been more relieved to receive a brown paper bag as a gift.
I love that little girl. She's just one of my three amazing reasons to celebrate being a mom.
If you're a mom, I hope you had a beautiful Mother's Day and were treated like a princess, too.
What's your favorite (or most shameful) Mother's Day gift story?


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42: The answer to life, the universe and everything
When Douglas Adams wrote The Hitchhiker's Guide to the Galaxy, he added a central joke which has become more famous over the years than the novel itself: "The answer to the ultimate question of life, the universe and everything is 42." Geeks have since wasted years and massive effort trying to ascribe some deep, symbolic significance to the number and its occurrences.
Now, in an attempt to cash in on their obsession, a new book published this week, 42: Douglas Adams' Amazingly Accurate Answer to Life, the Universe and Everything, looks at real-life occurrences of the number 42. The book is timed to coincide with the 10th anniversary of Adams's death this spring.
Scores of adolescents have posited theories about significance of the number. The actor Stephen Fry claimed to know the true answer, but won't tell, saying he'll take it to his grave. The author himself rather undermined the myriad analyses when he dismissed them all with the simple answer that the choice of the number was a joke.
"The answer to this is very simple," Adams said. "It was a joke. It had to be a number, an ordinary, smallish number, and I chose that one. Binary representations, base 13, Tibetan monks are all complete nonsense. I sat on my desk, stared in to the garden and thought 42 will do. I typed it out. End of story."
Throughout history, various numbers have had special meanings ascribed to them. Plato called the study of number symbolism "the highest level of knowledge" while Pythagoras believed numbers had souls as well as magical powers.
Meanwhile, millions of Hitchhiker's fans to this day persist in trying to decipher what they imagine was Adams' secret motivations. Here are 42 things to fuel their fascination with the number 42.
1. Queen Victoria's husband Prince Albert died aged 42; they had 42 grandchildren and their great-grandson, Edward VIII, abdicated at the age of 42.
2. The world's first book printed with movable type is the Gutenberg Bible which has 42 lines per page.
3. On page 42 of Harry Potter and the Philosopher's Stone, Harry discovers he's a wizard.
4. The first time Douglas Adams essayed the number 42 was in a sketch called "The Hole in the Wall Club". In it, comedian Griff Rhys Jones mentions the 42nd meeting of the Crawley and District Paranoid Society.
5. Lord Lucan's last known location was outside 42 Norman Road, Newhaven, East Sussex.
6. The Doctor Who episode entitled "42" lasts for 42 minutes.
7. Titanic was travelling at a speed equivalent to 42km/hour when it collided with an iceberg.
8. The marine battalion 42 Commando insists that it be known as "Four two, Sir!"
9. In east Asia, including parts of China, tall buildings often avoid having a 42nd floor because of tetraphobia – fear of the number four because the words "four" and "death" sound the same (si or sei). Likewise, four 14, 24, etc.
10. Elvis Presley died at the age of 42.
11. BBC Radio 4's Desert Island Discs was created in 1942. There are 42 guests per year.
12. Toy Story character Buzz Lightyear's spaceship is named 42.
13. Fox Mulder's apartment in the US TV series The X Files was number 42.
14. The youngest president of the United States,Theodore Roosevelt, was 42 when he was elected.
15. The office of Google's chief executive Eric Schmidt is called Building 42 of the firm's San Francisco complex.
16. The Bell-X1 rocket plane Glamorous Glennis piloted by Chuck Yeager, first broke the sound barrier at 42,000 feet.
17. The atomic bomb that devastated Nagasaki, Japan, contained the destructive power of 42 million sticks of dynamite.
18. A single Big Mac contains 42 per cent of the recommended daily intake of salt.
19. Cricket has 42 laws.
20. On page 42 of Bram Stoker's Dracula, Jonathan Harker discovers he is a prisoner of the vampire. And on the same page of Frankenstein, Victor Frankenstein reveals he is able to create life.
21. In Shakespeare's Romeo and Juliet, Friar Laurence gives Juliet a potion that allows for her to be in a death-like coma for "two and forty hours".
22. The three best-selling music albums – Michael Jackson's Thriller, AC/DC's Back in Black and Pink Floyd's The Dark Side of the Moon – last 42 minutes.
23. The result of the most famous game in English football – the world cup final of 1966 – was 4-2.
24. The type 42 vacuum tube was one of the most popular audio output amplifiers of the 1930s.
25. A marathon course is 42km and 195m.
26. Samuel Johnson compiled the Dictionary of the English Language, regarded as one of the greatest works of scholarship. In a nine-year period he defined a total of 42,777 words.
27. 42,000 balls were used at Wimbledon last year.
28. The wonder horse Nijinsky was 42 months old in 1970 when he became the last horse to win the English Triple Crown: the Derby; the 2000 Guineas and the St Leger.
29. The element molybdenum has the atomic number 42 and is also the 42nd most common element in the universe.
30. Dodi Fayed was 42 when he was killed alongside Princess Diana.
31. Cell 42 on Alcatraz Island was once home to Robert Stroud who was transferred to The Rock in 1942. After murdering a guard he spent 42 years in solitary confinement in different prisons.
32. In the Book of Revelation, it is prophesised that the beast will hold dominion over the earth for 42 months.
33. The Moorgate Tube disaster of 1975 killed 42 passengers.
34. When the growing numbers of Large Hadron Collider scientists acquired more office space recently, they named their new complex Building 42.
35. Lewis Carroll's Alice's Adventures in Wonderland has 42 illustrations.
36. 42 is the favourite number of Dr House, the American television doctor played by Hugh Laurie.
37. There are 42 US gallons in a barrel of oil.
38. In an episode of The Simpsons, police chief Wiggum wakes up to a question aimed at him and replies "42".
39. Best Western is the world's largest hotel chain with more than 4,200 hotels in 80 countries.
40. There are 42 principles of Ma'at, the ancient Egyptian goddess – and concept – of physical and moral law, order and truth.
41. Mungo Jerry's 1970 hit "In the Summertime", written by Ray Dorset, has a tempo of 42 beats per minute.
42. The band Level 42 chose their name in recognition of The Hitchhiker's Guide to the Galaxy and not – as is often repeated – after the world's tallest car park.


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Post Edited (unhappy32) : 5/26/2009 10:29:58 AM (GMT-6)
*Every tomorrow has two handles. We can take hold of it by the handle of anxiety, or by the handle of faith"*
*~* https://www.healingwell.com/donate *~*
It looks like everyone is having a difficult time right now. We just have to stick together and keep helping ourselves. Easier times are coming! Let us know what happens from your appointment on Wednesday. Take care!
60 mg. Prozac, Ativan as needed.
"The part can never be well unless the whole is well." Plato
Hey Ben,
I am so sorry about the delay in starting the CBT but remember to keep putting one foot in front of the other.
I know you will make it through my friend. I am sure you are worried about the lumps but try to stop googling and just let it be until the tests results are in, not good to get caught up in the anticipatory anxiety mode.
As for meds, I am not on an AD now for the depression as I did not find one that worked well and the side effects were not good. I do use the Valium and the Trazodone for sleep. I sleep well on 100 mg of Trazadone but I do wake up early. That is ok because I can always come here and read and post and just stay in the moment.
Take care and thank you for the update.
Co-Moderator, Anxiety and Panic Forum
DX: Anxiety, Depression, LPR (acid reflux)
Meds: Paxil, Nexium, Zantac
Thanks everyone for your help and lending an ear. My crying finally stopped. I'm not sure why I was crying except that everything is falling apart. So, I guess I just answered that question. I continue to learn and hope that I will be strong enough some day to accept anxiety completely.
Ben, I'm so glad your medication problems may be over. It sounds like you're on your way to recovery. Don't move too fast and don't forget to treat yourself well as you find peace. You deserve a wonderful, long, healthy life. I wish you well!


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Thursday, January 19, 2012
Performing & You.
In the last month or so, I have been talking with a lot of people about performing - musicians, dancers, students, and other creative types. Why we perform, how it makes us feel, what qualifies as a good or satisfying performance, what leaves us wanting more personally, and how to get satisfied more consistently.And what I discovered is that those who felt the most consistent and satisfied about their performances had similar reasons for WHY they performed.
I think a lot of people get into performing for the wrong reasons. That doesn't mean they won't eventually come to the right reasons, but I have to wonder if a lot of stress and heartache could be saved if they started from the right spot. Or maybe it's all part of the learning process. What are the "wrong reasons" anyway? I would say anything that blocks the flow of energy between the performer and the audience, and doesn't foster truth growth.
Performing is about having a shared experience on multiple levels. It's about communication, opening up a dialogue between you and the audience - you give something, they give something back, and so it cycles from there. The amazing thing about performing is that it is a communal experience. For many of us, it's like church - there is something sacred, something energy-based about it, as close to you can get to a divine experience on the earthly plane. Time moves differently on stage, and there's a sense of transformation, of reaching an altered state of existence.
If you're only performing to boost your ego, it's only going to go so far, because self-esteem can't be fostered from an audience glow, it's has to start from inside of you, YOUR own confidence in YOU. Eventually, the audience will catch on, and leave you crashing hard. Attention-seeking is disrespectful to the audience and negates the communication experience for both parties.
We all have to start somewhere. Not every performance is going to be a mystical, magical experience - but you have to start with getting experience in the first place. It takes practice to learn how to communicate properly. As long as you have a willingness to acknowledge that, and the desire TO communicate and share, then you are on the right path. Consider when you're putting a piece together, what is it that you want to say with it? How does it make you feel? How do you want your audience to feel? If you take the time to consider these things, you're on the right path.
Posted by Tempest at 7:27 AM 1 comments
Labels: dance performing church
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By James W, Sunday 15th July 2018
The summer is well and truly here but CBS Drama is keeping the hits coming to keep you in the shade with Season 6 of ER and Season 4 of The Love Boat!
As you'd expect at this time of year ER is busier than ever and when Season 6 starts n 17th August a visiting doctor reveals a secret, a nurse gives birth to twins, and a patient murders a young doctor! This season sees Paul McCrane, Goran Visnjic, Maura Tierney, Michael Michele, Erik Palladino and Ming-Na join the esteemed cast.
Then we hit the high seas for The Love Boat Season 4 on the 29th August where Julie and Gopher are becoming more than just friends when Gopher's old college buddy (played by Tom Hanks) shows up. Meanwhile, romance and comic intrigue reign on the high seas as 25 engaged couples board the Pacific Princess to compete in a 'Marriage-A-Thon Cruise', and a man (Dynasty's Al Corley) who jilted his bride-to-be shares the honeymoon with his brother and best man (Another World's Mark Pinter).
Related show tags: ER, THE LOVE BOAT MORE FEATURES Christmas movies weekdays in December
Posted on Sunday 25th November 2018
Weekdays at 2pm from December 17th, CBS Drama will be getting you in the Christmas spirit with a selection of movies that would warm even Scrooge's stone-cold heart! Movies include:
A Town without Christmas where a child's letter to Santa Claus captures the nation's attention. When young Chris writes that he wishes to leave this world so he will no longer be a burden to his divorcing parents, a race begins to find him before he harms himself. Then in Finding John Christmas Max, the Christmas angel, returns in a new story as he attempts to reunite a fallen hero with his family and bring dreams back into the life of a nurse struggling to save her E.R. from being closed.
Santa's good...SHARE: READ MORE More bed-side drama in November
Posted on Tuesday 30th October 2018
The multi award-winning ER explores the lives of the dedicated physicians and staff of an overburdened Chicago emergency room. These medical professionals remain determined to save lives in a place where nothing is taken for granted and nothing is certain… Nothing except that another desperate person will be rushed through the emergency room door in the next moment, in need of their help.
At the start of Season 3, Jeanie discovers she is HIV positive but refuses to disclose her status to the hospital. Her former lover, Dr. Peter Benton, tests negative. Having recently graduated from medical school, Carter now works as a surgical intern under Benton. Greene and Lewis's mutual attract...SHARE: READ MORE Dynasty - The final season!
Posted on Tuesday 30th October 2018
This hugely popular prime-time soap opera follows the exploits of the Carringtons and Colbys, both "oil-rich" family dynasties in Denver, Colorado, as they accrue and manipulate power and wealth.
In ninth and final season, Alexis is comforted by Dex in the wake of Sean's death, and the two renew their passionate love for each other; Fallon slips out of Jeff's room after Sammy Jo shows up unexpectedly to accept his marriage offer; and Blake is devastated by his fear that Krystle's disappearance may be caused by a severe mental disorder.
Dynasty Season 9 starts 15th November.SHARE: READ MORE Get your bitch fix with Dynasty Season 8
Posted on Thursday 4th October 2018
Dynasty, the hugely popular prime-time soap opera follows the exploits of the Carringtons and Colbys, both "oil-rich" family dynasties in Denver, CO, as they accrue and manipulate power and wealth.
In season 8, still held captive by the deranged Matthew Blaisdel, Blake and his family wait helplessly, as Blaisdel's obsession for Krystle grows dangerously stronger; witnessing Alexis' car plunge into the river, a handsome and mysterious stranger rescues her from the rushing current, and determined to thank her mysterious rescuer, Alexis finds the man she feels indebted to, but is dismayed by his casual acceptance of her
Dynasty Season 8 starts...SHARE: READ MORE Late to the party? Your chance to catch your CBS Drama favourites from the start!
Posted on Tuesday 25th September 2018
October is catch up month on CBS Drama and we're giving you the chance to paranormal series Medium and classic romantic series The Love Boat both from their very first episodes!
Medium is a captivating one-hour drama series, inspired by the life story of medium Allison Dubois, starring Patricia Arquette as a wife and mother of three who is trying to understand her natural intuition about people and her ability to communicate with the dead. While her husband Joe (Jake Weber) is as supportive and as loving as he can be, the couple is struggling to find a balance between her family life and Allison's powerful calling. At work, Allison is hired by dis...SHARE: READ MORE 10 wild west facts about Bonanza!
Posted on Tuesday 4th September 2018
The adventures of Ben Cartwright and his sons has entertained fans around the world for decades and can be seen on CBS Drama weekdays at 9am in Bonanza.
But how much do you know about this beloved series? Here's 10 obscure facts about the Cartwrights.
10: There were 431 episodes recorded between 1959 to 1973.
9: In 2002 the theme tune was ranked number 43 in an all time greatest list by TV Guide.
8: The theme also had lyrics written by Jay Livingston and Ray Evans. Here's a sample:
"We chased lady-luck, 'til we finally struck Bonanza. With a gun and a rope and a hat full of hope, planted a family tree. We got hold of a pot of gold, Bonanza...
Posted on Wednesday 29th August 2018
As you all know by now, Dynasty is the classic and incredibly popular prime-time soap opera which follows the exploits of the Carringtons and Colbys, both "oil-rich" family dynasties in Denver, CO, as they accrue and manipulate power and wealth.
In season 7, Alexis's life is spared as Krystle is able to restrain Blake's lethal temper; as La Mirage burns, Amanda is rescued by a mysterious stranger; Claudia is claimed victim by the ravaging flames, and Alexis turns the La Mirage fire into a scheme to bring Blake to his knees.
Don't miss a cat-fight weekdays at 10pm.SHARE: READ MORE Top 5 Unsolved Mysteries, can you explain them?
Posted on Friday 27th July 2018
Unsolved Mysteries is the cult series which presents accounts of bizarre and unnatural happenings. How many of the mysteries below can you explain?
5: Stigmata – This is when a person is afflicted with the wounds of Jesus's crucifixion. Usually appearing on hands and feet, the first recorded stigmata dates to St Francis of Assisi who lived between 1186 to 1226.
4: Jack the Ripper – The most famous serial killer of all time, Jack the Ripper stalked the foggy streets of London in the 1880s. Slaughtering at least 11 women, his identity is still unknown.
3: The Loch Ness Monster – For centuries it's been reported that a large, dinosaur...SHARE: READ MORE More love on the high seas in July
Posted on Saturday 23rd June 2018
It's officially the summer and thousands of Brits will be enjoying a cruise, many with their famalies and loved ones, others will be looking for love.
One thing is for sure it won't be as much fun as being on board The Love Boat!
Season 3 starts at 6pm on the 16th July where a swinging bachelor gets the shock of his life when the phony story he tells his gorgeous girlfriend turns out to be true.
Also, Gopher produces some hysterical hi-jinks to keep the unmarried daughter of Capt. Stubling's boss from sharing the honeymoon suite with her boyfriend, and Capt. Stubling falls for a recently divorced woman, who was on a previous cr...SHARE: READ MORE PICK OF THE WEEK
Wednesday 19 December
Saturday 15 December
Friday 14 December


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Love is in the Air!
The Commute Solutions' "Who Are You Riding With" bookmark campaign received a 2012 Bronze ADDY® Award during its February 9th show. This highly sought-after award was presented to TKO Advertising, who designed and created this amazing artwork for the CAMPO Commute Solutions program. We are thrilled and proud to have such a great team to work with!
Read & Ride with Commute Solutions and be on the lookout for even more great things to come! Scroll down below to check out these cool bookmark for yourself.


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Professor, Chemical Education;
Associate Dean, College of the SciencesPhone: 509-963-2622 Email: email@example.com
- 1995 - Ph.D., Arizona State University.
- 1987 - M.S., University of Wisconsin-Madison.
- 1985 - B.S., Northern Arizona University.
Research Interests:
Martha is currently serving as Associate Dean in the College of the Sciences
Recent Publications:
- Quitadamo, I. J., Faiola, C.*, Johnson, J., & Kurtz, M. J. (2008) Community-based Inquiry Improves Critical Thinking in General Education Biology. Cell Biology Education-Life Science Education, 7, 327-337.
- Quitadamo, I., Kurtz, M., Sorey, T., Pratt-Sitaula, B., and Palmquist, B. "Using e-Portfolio to Assess Pre-Service Teacher Performance," Journal of Washington Science Teachers Association, Nov. 2006.
- Kurtz, M. J.; Oursland, M.; Quitadamo, I. J. "Cougars across the curriculum: Using just-in-time technology to support integrated student research, preservice teacher development, and enhanced K-12 learning." Leadership Information, 5:4, p. 31, 2006.
- Kurtz, M. J. "Environment-based Integrated Learning: Building a Sustainable Future;" Proceedings of 4th International Conference on Science, Mathematics, and Technology Education, p. 359, 2006.
- Kurtz, M. J.; Oursland, M.; and Quitadamo, I. J. "Just-in-Time Technology that Supports Cougar Research Across the Curriculum;" Society for Information Technology & Teacher Education 16th International Conference Proceedings, p. 2701, 2005.
- Kurtz, M. J.; Oursland, M; Miller, J. and Quitadamo, I. "Project CAT" in PT3 Monograph, pg. 17, 2005.
- Kurtz, M. J. and Holden, B. E. "Analysis of a Distance Education Program in Organic Chemistry," J. Chem. Ed., 78, p. 1122, 2001.
- Baxter, L. M. and Kurtz, M. J. "When a Hypothesis is Not an Educated Guess," Science and Children, 38:7, p. 18, 2001.
- Kurtz, M. J. and Birk, J. P. "The Effect of Experience on the Retention and Elimination of Misconceptions on Molecular Structure and Bonding," J.Chem. Ed., 76, p. 124, 1999.
Recent Grants:
- "Yakima Watershed Activities To Enhance Research," NSF: GK-12, co-PI, $3M, funded for 5 yrs., 2007.
- "Center for Excellence in Science and Mathematics Education," CWU Spheres of Distinction, PI, $61,000, 2006.
- "Organic Chemistry," Higher Education Coordinating Board High Demand Programs, PI, $189,000, 2006.
- "Tools for Lifelong Learning," CWU SOAR Grant, co-PI, $8,500, 2005.
- "MSP Watershed Investigation Project," OSPI, Math/Science Partnership Program, Senior Personnel, $720,897, funded for 3 yrs., 2004.
- "Lincoln School Partnership," CWU Foundation Len Thayer Small Grant, PI, $590, 2004.
- "Middle Level Math/Science Endorsement," Higher Education Coordinating Board High Demand Programs, PI, $379,490; funding converted to annual base budget, 2003.
- "In Answer to A National Challenge: A Pilot Program to Increase Participation in Science, Technology and Mathematics (STEM) Fields," National Science Foundation, STEP, co-PI, $249,987, funded for 3 yrs., 2002.


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Silicone dolls are beautiful woman or a portion of the woman's body does not move. They do not speak, do not cry and they are very horny. It's so nice inside, they ejaculate faster than expected.
They are very often emotional presence, become a cherished object and respond to a sexual need.
Due to the Japanese post office size limitation Only EMS or UPS can be choose for customer from the USA
- Dimension H575×W420×D270mm
- Original Japanese Name リアルボディ+3Dボーンシステム ぽっちゃり持田まゆ
- Maker SSI Japan
- Product Weight 10kg
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