text:
Issue Index
07-19-04 Potter House offers unique gifts
By Janie Southard email@example.com
Do-it-yourself home decorators who've wondered where to get those great, big vases seen in magazines now can just troop into the Potter House at 108 S. Main St. "The vases can be used indoors or outside," says store manager Bonnie Rutschilling as she stands beside a 6-foot-tall grainy gold vase. The various pottery pieces in the shop are eye-catching, but the main focus of the shop is the ceramic painting studio in the back, according to Rutschilling of Celina. Store owner Kim Nation, whose maiden name was Potter, hence the Potter House, has arranged the shop for birthday parties, girls-night-out parties or individuals to come in and paint a piece of ceramics. Nation of Celina then will fire the piece in her kiln. "Prices start at $5.99 and include the greenware, paints, firing, glaze and two hours of studio time. We have a variety of items to paint including a full set of dishes, which would make a good bachelorette party. Each person could paint a piece of dinnerware for the bride," Rutschilling says. Throughout the store is a wealth of unusual items: floating candles shaped like martini olives, small glass cherries, a very small piano that is actually a wine rack and a lot of uniquely named food items. "Here's an herb dip called Hotter than Holy Moley; and here's She's the Boss Chili Sauce. We like the funny names plus the food is really good," Rutschilling says. There are also various brainy games for kids and adults as well as singing dolphin pens and other oddities. The store manager says they also are interested in selling local art on consignment. "We've already had some people come in with nice items, and we're interested in seeing more," she says. Store hours are Mondays through Fridays, 10 a.m. to 6 p.m., and Saturdays, 10 a.m. to 2 p.m.
Phone: (419)586-2371, Fax: (419)586-6271 All content copyright 2004 The Standard Printing Company P.O. Box 140, Celina, OH 45822


text: Hi All, New to the Droid world. I just wanted to know if anyone has had this problem before. For some reason my Droid will not charge ( brand new unit ) first time charging since the initial charge the night I got it. The plug is fine, the outlet is fine and the phone charges from the PC when I hook it up. Any ideas, should I take out the battery and then pop it back in, or does this seem like a different kind of beast. Any help would be welcome. Take care all. Lou

subset: commoncrawl


text:
Massachusetts native Dana Gould began his professional stand-up career at the tender age of 17, cutting his teeth in the comedy boom of the 1980's. He arrived in Los Angeles in the early 90's, where he became one of the founding members of the alternative comedy movement. After starring in the TV series Working and guesting on such shows as The Ben Stiller Show and Seinfeld, Dana joined the writing staff of The Simpsons, eventually becoming Executive Producer of the legendary show.
Dana left The Simpsons and rededicated himself to his stand-up career, adding to his numerous HBO specials and the best-selling comedy album, Funhouse. Dana's post-Simpsons output includes the one-hour special Let Me Put My Thoughts In You, and the just-released, I Know It's Wrong. The audio download of I Know It's Wrong recently debuted on iTunes at number one. 2013 saw Dana making his dramatic acting debut in Frank Darabont's period crime drama, Mob City, and his monthly podcast, The Dana Gould Hour, is widely regarded to be one of the finest-produced podcasts in the genre.
Dana wrote, produced and starred in the pilot Nolan Knows Best for ABC television, developed the pilot Dischord for F/X with The Foo Fighters' Dave Grohl, and is currently developing a wide variety of projects, as well as continuing to produce The Dana Gould Hour and touring the country as a stand-up comedian.


text:
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Cavaliers star says his ideology aligns with the Democratic candidate. Swing state help


text:
experiment: success!
Thanks to everyone who particpated in Open Mic Night II. You all left content that was interesting, funny and better than everything I managed to squeeze out this weekend.
We'll do this again. Just try not to show me up too much, ok?
[login has been deleted. come back next week for another chance to play]


text:
Melanie Potts
Joint Head of Road Traffic Accidents
Department: Personal Injury
E: firstname.lastname@example.com
Melanie joined the CLS Road Traffic Accident Department as a Qualified Solicitor in June 2010. She trained with a well-established local high street firm, specialising in Civil Litigation and Personal Injury and also advised clients with Debt and Housing problems as well as Wills and Powers of Attorney.
Melanie became an Associate Solicitor at Curtis Law Solicitors in December 2011 and Head of RTA in April 2012. With over 10 years' experience, Melanie advises on high value injury claims, complex fraud allegations as well as Credit Hire. She manages a team of 18 experienced litigators, each of whom have been specifically selected for their like-minded approach and work ethos.
If you need help, get in touch for free no-obligation advice. Simply fill out this form and we will be in touch within the hour.


text:
In celebration of 'Women In The Arts' month during March each year, guild members contribute items to fill a couple of the display cases at the Steele Memorial Library. This year our focus was 'Lace'. We displayed a variety of lace forms including lace made with thin wire.
Along with the month long display, we also hold a workshop. This year participants learned how to use roving and cloth in the projects in place of yarn.


text: Havenhoard is a world where dragons are as common as any common creature. Dragons don't always stick with their races alignment type and crossbreed dragons, half-dragons, and Dragonic creatures are all over the place. Openings to the outer and inner planes are extremely prevalent in places with outsiders popping up here and there as well as undead that won't stay dead.


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The Smoky Mountains National Park is one of the most visited parks in the U.S. Millions of people flock to the park every year and sometimes it can get very crowded especially during the summer time. The park has over 800 miles of trails ranging from easy to strenuous. Before you visit the park, you should research the types of trails that will suit you so that you can make the most of your trip.
If you are up for an adventurous trail with great views, then you have to go to the Chimney Tops trail. This 4 mile round trip trail is the most popular on the NewFound Gap Road. A short 2 mile hike will take you to the summit where you can get 360 degree views. The first part of the trail is not too steep but towards the end you have to climb nearly a 1000 ft over a quarter mile. Some people won't finish the trail because of the steep incline at the end. But if you are willing to make it to the top, the view is absolutely stunning.
The Alum Cave Trail is another fairly short hike which takes you to the Alum cave. This is not really a cave but a concave bluff. The first point on this trail is the Arch Rock. You will follow some steps which goes under this arch. The next landmark is Inspiration Point. From here you get sweeping views of Little Duck Hawk Ridge. You can also see the Eye of the Needle from here. At 2.2 miles you'll reach Alum Cave. You should be careful around Alum Cave in the winter time because icicles will form on the bluff and may fall on you.
A trip to Smoky Mountains isn't complete until you see a waterfall. There are many waterfall trails but one of the most popular is the Laurel Falls. This is a short 2.3 mile roundtrip paved trail that takes you to Laurel Falls. You may want to get to this trail earlier otherwise it gets really packed. Laurel Falls is a 60 foot fall and is very picturesque. You may also wish to continue on the trail another 2 miles which will take you to an old fire tower.


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|Servant of the Empire
Spectra (1991), Mass Market Paperback, 704 pages
|This is the sequel to Daughter of the Empire. The book is long at nearly 700 pages, and contains two basic plots, although both are related and use the same characters. They could easily have been separate books -- one of the things I like about this book is that it tells more of the story than it absolutely has to, whilst still being continuously engaging. The events of this book run parallel to Pug's time on Kelwan from Magician (Apprentice and Master) and its also nice to see an alternate perspective on those events. The main thrust of this book is that while tradition is important, not being wasteful of the resources you're handed is important too.
This book is excellent.
Tags for this post: book raymond_e_feist_and_janny_wurts midkemia kelewan politics raymond_e_feist janny_wurts fantasy sword_and_sorcery
Related posts: Mistress of the Empire; Daughter of the Empire; Magician: Master; Raymond E Feist's Empire Trilogy; Silverthorn; The Riftwar Series
posted at: 19:23 | path: /book/Raymond_E_Feist_and_Janny_Wurts | permanent link to this entry


text: I've been using Handbrake to rip a few of my DVD's and I'm having a problem with subtitles in The Bourne Supremacy. I cannot seem to find the setting for ripping the movie in English but with English subtitles for the Russian dialogue. Can somebody help me to solve this? Thanks, Andrew.


text:
Tales From The Other Railway - exploring the warped world of Diesel and the other Sodor rejects...
Tales From The Other Railway is
a Parody series based on the Mainland-based Diesel characters from the Railway Series books and the (Thomas) TV
The stories revolve around the every day misadventures of
Diesel and his associates as they work together (or against one another) under the less than
capable guidance of The Thin Git. Their adventures are often based on those that have taken place on Sodor, but while
clouds never last long on Sodor - they hang over The Other Railway continuously!
Written by Professor Vengeance, Tales From The Other
Railway has spanned three series of written parodies and become SiF's No.1 Parody Series. The format has also been
carried across to media production, where two audio specials have been recorded, as well as a number of accompanying songs
and narratives. Here, we have compiled the most voted for stories of each written parody series and put them here to
showcase the warped, vulgar and decripid Other Railway...
10th May 2010


text: Submit Testimonial Please use the form below to submit a testimonial. We greatly appreciate it! Name Displayed (Format Sample: William H.) Company/Organization (optional) Website URL (optional) Location (City, State - optional) Testimonial Rate 5 Stars4 Stars3 Stars2 Stars1 Star Email (optional - will not be published) Are you Human? 66 + 8 = Submit Entry


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While watching Good Morning America a few days ago, I saw a harrowing video from Houston TX. It was an eyewitness video of a fire at a construction site of an apartment building. On the fifth story was a construction worker stranded while the fire raged on a few feet away from him. The video contained the audio of the filmer's panicked voice, as she watched helplessly through a window across from the construction site. My heart leapt as I watched the construction worker swung like a professional acrobat to the lower level balcony away from the fire. Just when the fire ladder reached him and he crawled onto the rungs, the fifth floor's blazing wall collapsed.
Thankfully, the construction worker got off of the balcony alive. As I watched other news channels of this same video (it was much easier to watch knowing that is would end in good news) I was struck by how calm and methodical the construction worker was in this moment of crisis. He really inspired me step by step on how to handle any crisis that I may face:
· Don't panic—he was surrounded by a wall of fire, yet he appeared calm and in control.
· Assess the situation-- he knew he had to remove himself from that balcony stat.
· Don't be afraid to ask for help—he waved towards the firefighter who was bringing the ladder close to him safely
· Trust in your abilities—he confidently swung himself onto the next floor balcony and hopped on the ladder that eventually took him to safety without a moment's hesitation
Hopefully, I won't be in the exact situation as this brave construction worker was, but I will remember this news story as a true life lesson.


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At Bitwize we believe that doing it right the first time is the only way to get things done. As far as websites go, this is no easy task as all good websites need to constantly evolve with fresh content and other updates. To tackle this hurdle for our clients we have developed Content Management Systems (CMS) which allow you, the website owner to update the site as you need. The second part of our philosophy is to dilegently look for ways to automate everyday tasks in order for our clients to spend more time on growing their business rather than just keeping it running. The need for a "program" arises when a task must be done repeatedly. By automating those monotonous tasks with our technologies out clients are that much closer to success. We measure our success not only by how well your site produces for you but also by how much time and money you save by not coming back to us for every little change.
Read more about CMS
Bitwize provides full service maintenance, which enables our clients to update their sites on a regular basis, without the normally exorbitant cost of doing so. This philosophy of constant evolution in a web site promotes a motivational atmosphere in which both Bitwize, and the client team up to assure that the production is up to date, and income producing.
Contact us
for more information on any of our services.
When it comes to design Bitwize offers a full spectrum of solutions. Whether you're looking for a custom site built around your corporate identity or a personal site to show your pictures to friends and family we will work with you to create a design that is professional, attractive and optimized to load as quickly as possible. At Bitwize we take pride in our work and pay attention to detail on every aspect of your site.
Through our experience we have come to find that the design is the most time consuming part of developing a website. To answer this bottleneck we have partnered with Template Monster. Tempalte Monster has thousands or professionally designed website templates which we offer at a 10% discount. Unless you're absolutely set on a custom designed site we typically direct you to the Template Monster site to either choose a template or give us ideas as to what styles you would like to see on your site. That way we get working on your site with a running start and work on the details that make it functional.
Bitwize offers a full range of design services including web design, graphic design, logos, business cards, letterhead, flyers, animation and 3D rendered images.
Bitwize is an integrated single-source web development firm. With one phone call you get a team of highly-skilled experts with a business-driven common-sense approach.
Our professional team of developers can handle just about any application thrown at them. We do our best to live by the moto, "If you can dream it, we can build it". Our primary focus is on Microsofts ASP.NET which gives us a huge tool set that enables us to get your site up and running with all the bells and whistles in the shortest amount of time possible. We have an in house staff as well as designers and developers contracted with us throughout the United States that provide the needed expertise in all areas of development to make your project a reality. This allows us to use only the "cream of the crop" to develop your project at the best pricing available.
Truth be known, most websites do little to help their company's bottomline. Not because the web is an unfertile marketplace, but because most websites are lacking key components. Proper application of:
Web Best Practices
Strategic Creative
Effective Copy
Technical Innovation
Savvy Marketing
Sound Business Theory
is what separates typical websites from performance-driven producers. This is what separates a Bitwize website from the rest.
Programming and Scripting languages used:
ASP.NET c#
.NET c# Windows Applications
C/C++ (MS Visual Studio / Borland Builder)
and more!
Website maintenance is the most often over looked part of development. Bitwize keeps this in mind from the start building websites that are easily updated. Most of the sites we build have seperate secure administration sections where you can log-in and make updates to your site through our
Content Management System (CMS)
If you currently have a website we offer consulting services that measure the success of your site and find places where it could be improved. Often times, a few changes here and there can bring your site up to date and get your clients making positive comments about your site.
Bitwize Maintenance Plans
give you the flexibility to add on to your existing site and the peace of mind that you have a professional developer on call 24/7 should anything need to be done. Coupled with our Content Management System (CMS) Bitwize offers the end all solution to keeping your site up to date and fresh.
Most website and business application are driven by some sort of database on the back-end. Bitwize developers have extensive experience with Microsoft SQL Server 2000 and Microsoft Access. What does this mean to you? Experience is king when it comes to database design and development. Imagine your website being launched, then you notice that you need a few more fields on your signup form. A properly designed database should be able to handle these changes gracefully and quickly. An inproperly designed database will often lead to many changes potentially affecting a lot of code costing you time and money.
Often times your data is a fundamental part of your business. Bitwize realizes this and makes sure that you data is secure and backed up on a regular basis. Any sensitive data like credit card numbers is encrypted in the database so only you can see the information.
Flash animation is not for every web site, but for customers with faster Internet connections the razzle dazzle can be very impressive. We will help you in determining if Flash is in the best interests of your customers. We can also implement different degrees of Flash animation such as, full Flash sites, partial or minimal animation.
If you are looking for a Flash presentation, streaming video, intro page, navigation or an entire flash driven web site, we can turn your dream into a reality. We use state of the art equipment and the latest version software to develop your graphics and website.
Shopping on the Internet is fast becoming a way of life for many people. Instead of fighting crowds and traffic, many people just fire up the computer and surf the net to find their bargains. The only inconvenience involved is waiting for the product to be shipped to them. But in most cases their package can be shipped overnight and arrive at their door the next day.
So whether you are upgrading an existing online store, wanting to open a new store or are expanding your established store and making your products available online, Bitwize Site Solutions can provide everything needed to get your business online and selling your products, FAST!
We offer numerous solutions that help you accept online payments from your customers including
Paypal, Authorize.net, linkpoint, Cardservice International Merchant accounts and more
Your store will enevitably need some sort of shopping cart system built into it. Bitwize has worked with low cost, off the shelf solutions as well as custom shopping carts. What ever your need is we will work with you to find a solution for your online store front that will make your customers feel confident and secure about purchasing from you.
Bitwize has partnered with
Ultima Hosts
to provide our clients with the most reliable and afforable packages around. Ultima offers a broad range of hosting options that can be customized to fit your needs.
Contact us for a customized plan and price!
Every great business starts with an idea or dream just like every good website starts with a good domain name. In order to give our clients the power and piece of mind that their domain names are secure, afforable and offer all the services a good registrar should offer Bitwize has teamed up with register.com to bring you up to the starting line quickly and keep pace with all your changing needs throughout the life of your website.
Get rid of that old Hotmail or Yahoo or whoever.com email address and get your own name @ your domain. Bitwize offers 2 solutions to your email needs. We offer POP3 & WEBMAIL email accounts through Register.com which come in packs of 10 email boxes at $45 a year, or we can put together a custom account with the following services available: Postini.com, the #1 rated junk mail and anti-virus filtering, Exchange Server 2003: Includes free Outlook 2003, shared calendar, free/busy scheduling, SmartPhone mobile access, shared contacts and calendars. 100 MB.
Bitwize Networks © 1998-2015


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Version 3, 220.127.116.11 am 1.8.2007 08:47
"Server not found" am 31.7.2007 --benni
am 1.8.2007 läufts
Neue Seiten im Kontext
Dienstag, 10. April 2007
Sites like videntity and claimID are now hooking together OpenID and microformats to help provide for the first distributed social networking schemes. These are the seeds of something really exciting; the ability to tie single sign-on with portable social networking means we can quickly login to any site and then pull our social networks along with us. Its going to take time and quite a bit more work to get sites to adopt a standardized means for doing this but its inevitable now that OpenID is taking hold.


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Please check back for the 2019 Pool Fees
There are 3 ways to use the Marinwood Pool:
1) Purchase a Pool Membership and join for the season
2) Purchase a 5-swim punch pass
3) Drop in for the day (only available during Recreation Swim hours)
2018 Pool Memberships - Join for the Season
Resident Family (up to 4 persons) $333
Fee for additional family members $ 21
Resident Couple $254
Resident Individual $169
Resident Senior (60+ years) $128
Resident Senior Couple $192
Non-Resident Family (up to 4 persons) $417
Fee for additional family members $ 33
Non-Resident Couple $318
Non-Resident Individual $212
Non-Resident Senior (60+ yrs.) $159
Non-Resident Senior Couple $240
To join the pool for the 2018 season, click here to purchase your membership online!
Benefits of being a pool member include:
-Full season access to the pool during members-only Lap Swim and Tot Pool hours, as well as Recreation Swim hours
-guest passes for family and friends (valid during Recreation Swim hours)
-discounts on swim lessons
-discounts on pool parties and picnic rentals
-disounts on summer camps
-free coffee and wifi after your swim
5-Swim Punch Pass
(grants holder access to the pool during members-only Lap Swim and Tot Pool hours, as well as Recreation Swim hours)
$35 Non-resident
$25 Marinwood Resident
Daily Drop-ins
(only accepted during Recreation Swim Hours)
Residents: Non-Residents:
Youth $5 Youth $7
Adults $7 Adults $9


text:
The Global Military Fixed-Wing Aircraft Market 2016-2026is a new market research publication announced by Reportstack. During the forecast period the demand for Military Fixed-Wing Aircraft is expected to be driven by the ongoing global turmoil, internal and external security threats, fleet replacement programs, modernization strategies and territorial disputes across the world. Additionally, emerging economies in the Middle East and South Asian regions are witnessing increasing defense expenditure and are therefore likely to present global military aircraft manufacturers with greater opportunities in the coming decade.
Key Findings
- The global Military Fixed-Wing Aircraft market is expected to be worth US$61.2 billion in 2016 and is expected increase to US$88.9 billion by 2026, representing a CAGR of 3.81% during the forecast period
- The market is expected to be dominated by North America, occupying 33% of the market share, followed by Asia-Pacific and Europe, with 25% share each. The Middle East, Latin America, and Africa are expected to account for the remaining 17% of the overall market
- The multi-role aircraft segment is estimated to account for 56.8% of the global Military Fixed-Wing Aircraftmarket.Transport and reconnaissance and surveillance segment are also expected to account for a significant portion of the total Military Fixed-Wing Aircraftmarket during the forecast period, with shares of 24% and 8.8% respectively
- Bombers and Training aircrafttogether will account for the remaining 10.4% of global Military Fixed-Wing Aircraftexpenditure
To access full report with TOC, please visit The Global Military Fixed-Wing Aircraft Market 2016-2026.
The Global Military Fixed-Wing AircraftMarket 2016-2026 report offers a detailed analysis of the industry with market size forecasts covering the next ten years. This report will also analyze factors that influence demand for Military Fixed-Wing Aircraft, key market trends, and challenges faced by industry participants. In particular, it provides an in-depth analysis of the following:
- Market size and drivers: detailed analysis during 2016-2026, including highlights of the demand drivers and growth stimulators. It also provides a snapshot of the spending and modernization patterns of different regions around the world
- Regional highlights: study of the key markets in each region, providing an analysis of the key segments of the market that are expected to be in demand
- Major programs: details of the key programs in each segment, which are expected to be executed during 2016-2026
Reasons To Buy
- Determine prospective investment areas based on a detailed trend analysis of the global Military Fixed-Wing Aircraftmarket over the next ten years
- Gain in-depth understanding about the underlying factors driving demand for different Military Fixed-Wing Aircraftsegments in the top spending countries across the world and identify the opportunities offered by each of them
- Strengthen your understandingof the market in terms of demand drivers, industry trends, and the latest technological developments, among others
- Identify the major channels that are driving the global Military Fixed-Wing Aircraftmarket, providing a clear picture about future opportunities that can be tapped, resulting in revenue expansion
- Channelize resources by focusing on the ongoing programs that are being undertaken by the internal ministries of different countries within the Military Fixed-Wing Aircraftmarket
- Make correct business decisions based on thorough analysis of the total competitive landscape of the sector with detailed profiles of the top Military Fixed-Wing
- Aircraftservice providers around the world which include information about their products, alliances, recent contract wins and financial analysis wherever available
Companies Mentioned
Lockheed Martin Corporation Boeing Saab BAE Systems Northrop Grumman Corporation,Airbus Defense and Space Embraer Dassalt Aviation Russian Aircraft Corporation Pilatus Aircraft Ltd AleniaAermachhi Eurofighter Hindustan Aeronautics Limited (HAL)
Debora White
Manager - Marketing
Ph: +1-888-789-6604
Reportstack Market Research


text:
Friday, May 11, 2012
SummerWorks 2012
jsquared.theatre is pleased to announce that its new play Ally & Kev will be presented as part of the 2012 SummerWorks Theatre Festival, from August 9th to 19th. The play will showcase three of the most exciting actors in city: Cara Gee, Jeff Irving and Rosemary Dunsmore, with set and costume design by Akiva Romer Segal, lighting design by Alaina Perttula, stage management by Nicole Myers and original music by Petty Victories. Stay tuned for more details and for more information on the festival please visit the SummerWorks website.
Posted by jsquared.theatre at 12:59 PM
No comments:
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text:
Woman back in custody after mistaken Mohave County release
January 12, 2018
KINGMAN, Ariz. (AP) — Mohave County authorities say a woman who was mistakenly released from jail is back in custody.
Melissa Bexell turned herself in at the county jail Thursday evening. She told officials she was confused about her release and returned when she learned she was being sought.
The 38-year-old Bexell was being held on a felony theft charge and a misdemeanor obstructing charge out of Bear Lake County, Idaho.
Sheriff's officials said Bexell was not considered to be a danger to the public.


text:
Congressman Ted Poe (TX-02)
The year was 1969. Nixon was sworn in as president; Vietnam was coming to an end; and Americans were divided on almost every social issue of the time. The Manson murders, Chappaquiddick and Woodstock topped the news. Beatle mania took the US by storm, John and Yoko led the hippie haze; Merle Haggardís ìOkie from Muskogeeî hit Billboardís #1; ìLaugh-Inî and ìGunsmokeî were the most watched television shows; and Barbara Streisand took home the Oscar for Best Actress in ìFunny Girl.î It was a year of generation defining events.
But as the divided decade came to an end, Americans were united in a seemingly unbelievable quest. On July 20, 1969, I was sitting xxxÖÖ..
With the world glued to television sets in every home, school, church and auditorium we could fill, we watched the unbelievable unfold before our eyes and those famous words became seared in our memories: Houston, the Eagle has landed.
At 3:17pm Houston time, Neil Armstrong became the first name to set foot on the moon. At that very moment, a country divided came together. In the ìRace to Space,î the United States had become the first to put a man on the moon.
You see, ìHoustonî was the first word the world heard when we put a man on the moon ñ not ìMoscow,î ìBejing,î or ìTehran.î
And that's just the way it is.


text:
Everything you need to connect with your childcare parents. From instant messaging, to media sharing, calendars and daily reports. Bloomz makes all your parental communication quick, simple and easy
Create a room for free
...or sign up your center now
Our exclusive partnership with AAP – Ohio Chapter provides you and your parental community with high quality and relevant health, wellness and medical information for you kids, directly from the American Academy of Pediatrics.
Receive quality health information, from a trusted source, to keep your childcare kids happy and healthy, all while keeping the parents involved.
Join now, and be a part of the growing childcare community already using Bloomz. Let's make connecting and communicating with your parents, fast, easy and relevant.
Quick Daily Updates:Share updates about the day's activities, reminders, etc.
Photo & Video Sharing:Send special moments to the whole group or to specific parents.
Calendar & Reminders:Manage your center's calendar and events from one place.
Parent Meetings and Volunteer Signups:Easy planning and participation makes signups a breeze.
Daily Sheets/Reports:Keep record of all activities like naps, potty, meals and more.
2-Way Messaging:Instantly reach one or more parents through in-app messaging.
Private & Secure:Share with confidence, knowing everything on Bloomz is protected by strict security measures.
Quick daily updates with Bloomz save you hours of informal meetings and phone calls.
Meet busy parents where they are and streamline communication.
Bloomz has everything you and your parents need in one easy-to-use app.
Bloomz offers plans to fit your needs, so go ahead and jump start your community building efforts. If you want to try Bloomz for your Childcare Center, please fill out the form above and we will gladly set your school up.Sign up your center


text:
The Fantastic Neighborhood crew answers all the big PAX East questions:
How good was this years swag? How awesome was it to wait in line for two hours to see a forty-five minute pannel? What was the game of show?
Hint: It involved Diving. And Kicking.
This week's Game Club game is Cart Life. Get your anti-depressants ready. Next week's game will be the first five or six hours of Miasmata.


text:
I was hoping this issue would be resolved before Exchange 2013 RTM CU1 was released, but apparently not. This only affects upgrades from Exchange 2013 RTM to RTM CU1.
During the installation of Exchange 2013 RTM CU1, setup runs a prerequisite check on the Exchange 2013 RTM server. Among other things, setup checks to see that required Windows features and roles are installed. If they're not, setup cannot continue and you need to cancel the installation to install the necessary prerequisites. The prerequisite check stage is also the last point where you can cancel the installation for any other reason.
Unfortunately, setup stops the Microsoft Exchange Transport service during the prerequisite check and does not restart it if you cancel setup to install the prerequisites. This means that email flow is affected prior to installing CU1.
If you do cancel installation for any reason after setup runs the prerequisite check, make sure you manually restart the Microsoft Exchange Transport service.


text:
PAD: Walking Program
PAD: Walking Program
What is peripheral arterial disease (PAD)?
PAD is the narrowing or blockage of the arteries of the circulatory system. PAD occurs in the vessels that carry blood to the arms and legs.
What is Claudication?
Claudication is a symptom of PAD. It is often described as a painful cramping of the leg muscles that occurs when walking. The pain is often noticed in the calf, but may also be felt in the buttocks or thighs. When at rest, the muscles require less blood flow, so the pain typically goes away.
What are the benefits of a walking program?
A regular walking program is important and will help you:
- Increase the length of time you are able to walk before needing to rest.
- Reduce your leg pain.
- Improve or maintain muscle tone.
- Lose weight or maintain your weight, especially when combined with dietary changes.
- Reduce your risk factors for a heart attack or stroke.
- Improve your overall sense of well-being and reduce symptoms of anxiety and depression.
- Improve your quality of life.
Reviewed: 02/16


text:
This is from a stunning piece of work from which this photo represents but a small part.
Monday, 8 June 2009
Grafitti in Hongdae
Posted by vegted at 12:54 3 comments:
More Character Art from Hongdae
Posted by vegted at 01:56 No comments:
Labels: Character Art, Hongdae, NANA
Hongdae Doors
Posted by vegted at 01:48 1 comment:
ARS in Hongdae
Posted by vegted at 00:56 No comments:
More Stencil Art from Hongdae
Posted by vegted at 00:36 No comments:
Labels: Hongdae, Stencil art
Saturday, 30 May 2009
Friday, 29 May 2009
Hongdae Stencils - DOUBLE P
These are some of the most extensive stencils i've found. DOUBLE P has something to say and has found the tools to say it.
Posted by vegted at 00:05 No comments:
Labels: DOUBLE P, Hongdae, Stencil art
Thursday, 28 May 2009
Hongdae Paste Ups
Posted by vegted at 06:46 No comments:
Hongdae Character Art Part One
'Nana', I saw this tag a lot and in many genres and styles. This set is under the enormous 'Nana' umbrella. There'll be lots more 'Nana' to come.
Posted by vegted at 05:57 1 comment:
Stencil Art in Hongdae Part One
Hongdae in Seoul seems to be the mecca as far as wall arts is concerned. I spent a few hours there this afternoon and was unable to traverse every street and explore every nook and cranny. I'll be back for more. For now however I'll be spending the next few days posting images from today's exploration. First up, a set of Stencil Art of which there was a diverse selection.
Posted by vegted at 05:08 No comments:
Labels: Hongdae, Realization Crew, Stencil art
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Cooler Master Announces New All-in-One Cooler
Posted: 03:39PM
Author: CheeseMan42
Cooler Master has announced a new all-in-one liquid cooler, the MasterLiquid Maker 92, which "skirts the divide between liquid and air cooling by combining properties from both." The pump and radiator were combined into a single piece flanked by two MasterFan Pro 92mm fans and attached directly to the CPU mounting apparatus. It uses a swivel mechanism to allow for horizontal or vertical fan configurations, giving users options for different size cases. Cooler Master will begin accepting a limited number of pre-order on August 30 with availability sometime in September.
Source: Press Release


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Celebrating the best in filmmaking from around the world in the
heart of London
"The UK Film Festival is the most focussed, passionate and quality driven film festival in the UK, their invaluable support helped get me to the Oscars in 2015, where I won the Academy Award for best short film"
Mat Kirkby – Oscar winner and Director at Ridley Scott Associates
"Their immense passion for support to new and fresh undiscovered voices makes the UK Film Festival a very important career stepping stone for every filmmaker. Thanks to the UKFF I managed to achieve unprecedented results and advance significantly in my career."
Petros Silvestros - Director – Twice Berlinale Winner
"UKFF is an amazing festival discovering and showcasing an incredible selection of local and international films. We were honoured to have our UK premiere here which offered us great exposure both in the UK and across the festival circuit."
Jamie Donoughue, Director of "Shok" – Oscar Nominee
Guardian Newspaper Review:
Film is not all about awards, but if you need a seal of quality for this relatively new festival, last year's overall winner, Mat Kirkby's "The Phone Call", went on to win the Oscar for best live-action short. In addition, the festival's writing competition, in which the best script is made into a film, has also produced the winners at the Berlin film festival two years in a row. Some on show this year have already won awards, meanwhile: Colombian motherhood story "Leidi" took the top prize at Cannes while Belfast childhood comedy "Boogaloo And Graham" won the Bafta (and an Oscar nomination). Kirkby returns to judge this year's shorts, which play in feature-length programmes, with prizes in documentary, animated, international and British shorts up for grabs. There are also filmmaker Q&As and a few features, including a version of Roald Dahl's Esio Trot starring Judi Dench and Dustin Hoffman. Good company to be in, then. Read more here
Meet the team
Join UKFF
Kind words
Festival programme
Venue and tickets
Film Submissions
Fees and deadlines
Categories & Prizes
Script Competitions
3 Minute Script Competition
Feature Script Competition
Lux Prize
Lux Prize
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Official Film Festival awards sponsor
Festival Programme
Venues & Tickets


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Hot and dry July weather can cause havoc in gardens, so use water wisely and keep up with plant maintenance so gardens look their best this month, say experts at Agromin, an Oxnard-based manufacturer of earth-friendly compost products made from organic material collected from more than 50 California cities including those in Santa Barbara County.
» Water wisely: You can still have a beautiful garden without using a lot of water, even during the summer. Early morning watering allows for deep soil penetration (6 to 8 inches) and reduces evaporation. Consider using a water probe to check moisture levels. Use soaker hoses for gardens and water in the early morning as well. Be sure to add mulch. Mulch will retain water, which is important during the year's hottest months — and keeps roots cool even during the heat of the day. It also reduces erosion so its use on hillsides and slopes is recommended.
» Remove "dead heads": A daily July task in a flower garden is to cut back droopy or brown flowers. This will not only keep the garden looking fresh, but will encourage new flower growth for the remainder of summer.
» Add color to your garden: Stop by any nursery in July and you will see an array of plants with brilliantly colored flowers. If there is a bare spot in your garden, an easy quick fix is to add already-blooming annuals. The color will not last long, however, typically through early fall.
» Harvest vegetables: Pick vegetables as soon as they are ripe. Also, remove any overripe fruit immediately since this fruit quickly attracts bugs. Do not let zucchini get too big. They are at their best when 4 or 5 inches long. Watermelons will be ready to pick when the vine leading to the fruit turns brown, the watermelon skin becomes dull and its bottom (the part touching the ground) is a yellowish color.
» Still time to plant vegetables: Add vegetable plants to your garden for a late summer, early fall harvest. These vegetables include beans, beets, carrots, corn, cantaloupe, okra squash and spinach.
Click here for more gardening tips.
— Diane Zakian Rumbaugh is a publicist representing Agromin.


text: Ok so I'm on gummyjar still (lol) and I'm finally going to install liberty when 1.5 is released.. I know I can install it on top of gummyjar but id rather start fresh for a few different reasons. So anyway, the question is: how should I factory reset my phone? Should I .sbf using rsd lite? If so what .sbf do I dl for droid 2? Or should I factory reset/wipe data in clockwork recovery Or finally reset from within the settings in the phone. This may be a dumb question, but I just want to make sure so I only have to do it once. Thanks! Sent from my DROID2 using DroidForums App


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NEW YORK (AP) -Sukhwinder Sandhu plans to welcome the New Year in a quiet place surrounded by flowers and glittering lights: his Sikh temple in New York City.
He has no doubt that God will be at all millennium observances, no matter how loud. ``God is everywhere,'' he says, smiling broadly beneath his turban. ``God will be in Times Square, too.''
Still, while shouts of the crowds will mark the New Year for millions, legions of men and women throughout the country plan to herald the millennium in private prayer and communal worship.
Protestants will hold prayer vigils and Catholics will light candles, though the turn of a year is not normally a time of religious observances. Even those whose traditions do not recognize the Gregorian year 2000 are taking notice.
Buddhists will chant for peace. Pagans will celebrate beginnings and ends. And while the Christian milestone holds no religious significance for Jews and Muslims, some say that ushering in a new century carries its own spiritual weight.
``There's a large group of people in America who are making sure spirituality is somehow a part of New Year's Eve,'' says the Rev. Cecil Williams of Glide Memorial United Methodist Church in San Francisco.
When church members expressed a need for something spiritual at New Year's, Williams helped plan an interfaith celebration of music, dance, poetry and prayer to be held in Union Square.
``More people ... want something that gives meaning to their lives,'' Williams says. ``Not just a rowdy yelling, screaming ... drunken experience. What they want is an experience of the spirit.''
Sixteen-year-old Anna Whitlow agrees. She'll be spending the week at Winterlight, a Christian youth retreat in Hendersonville, N.C.
``It's cool making a start of the century knowing that you're going to be real close to God,'' says Whitlow, who will travel from her home in Baton Rouge, La. ``I can feel free to be myself and pray and talk about God.''
She's not alone.
In Washington, D.C., a coalition of religious groups will hold events, including a New Year's Eve service at the Washington National Cathedral with Archbishop Desmond Tutu. It's part of the ''72 Hours Project'' in which religious groups around the world will hold services to promote peace. The Cathedral of St. John the Divine in New York will open its doors all night for millennial worship, hosting a concert with Paul Winter.
More than 100 people - three times the usual number - will join the Franciscan Friars and the Sisters of the Atonement for their annual New Year's retreat. They will stand on the top of the Mount of the Atonement in Garrison, N.Y., where they'll wait in silence for the millennium, and then descend carrying torches.
At San Francisco's Grace Cathedral Episcopal Church, New Year's Eve coordinator Tom Keelan has set up a medieval labyrinth walk to be held inside and outside the church.
``It's a calming meditative way for people to bring in the millennium,'' says Keelan, who expects 3,000 people to walk the winding route. ``A lot of people want to begin walking in 1999 and end in the year 2000.''
Meanwhile, in the northeast Michigan community of Alpena, St. Anne Catholic Church hopes to draw 100 people for a song-filled Mass followed by a ``time of adoration'' as the millennium nears.
``Two thousand years of Christianity,'' says the Rev. Joe Blasko. ``Of anyplace you want to be, it's in a church worshipping.''
Several Buddhist groups will hold retreats that address suffering and compassion. As midnight approaches, the Vajralama Buddhist Center in Seattle will offer a guided meditation ``on the mind of enlightenment.''
No place to go on Dec. 31?
On the Web, author James Redfield will lead what he describes as a global wave of prayer.
Another spiritual party is being thrown by the Taos, N.M.-based All One Tribe Foundation. Participants worldwide will drum together in unison for the final hours of 1999.
Mormons are not planning church celebrations. And Muslims will not be marking the beginning of the Christian calendar during their own holy month of Ramadan, though they may take part in secular celebrations.
New Year's Eve this year corresponds with the Jewish Sabbath, and some groups want to discourage celebrations. In New York, a student planned a large Sabbath dinner at a Kosher restaurant for New Year's Eve.But the Orthodox Union, which certifies that restaurants meet Kosher dietary laws, forbade the restaurant from holding the event on the grounds that it could turn into a celebration of a Christian holiday.
Still, numerous Jewish congregations are marking the moment. The National Jewish Center for Learning and Leadership is calling on Jews to make New Year's Eve ``a night when we, as Jews, reflect on what we have contributed to the world, and what we might do to improve it.''


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English Bisaya Translation of
In english bisaya dictionary, "okra" is " okra". See more translations below.
- okra noun
- okra
If you know something about this term, share it here. Many people are also searching for information about okra. Help them find it, make them happy.
Let us help each other. Please be polite in asking for help and sharing thoughts. Sort the comments to "Reverse Chronological" to see the latest posts.


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When my son Josh was about six, we found a children's book at the library with short stories and he fixed on one, in particular, that fascinated him. It surprised us both because it wasn't what you would normally call a "children's" story.
Instead, it was about how a mother prevented Death from taking her baby. She did this by making a recording of her baby's cry and setting up recordings in different rooms. Somehow or other, the time limit for Death ran out and the baby was saved.
Instead, it was about how a mother prevented Death from taking her baby. She did this by making a recording of her baby's cry and setting up recordings in different rooms. Somehow or other, the time limit for Death ran out and the baby was saved.
We read this story over and over again. Josh was beginning to learn about death and had already learned about divorce, as his dad and I split up when he was five. While we talked about everyone being born and dying, and of course living in between, I think my son was most intrigued with the notion of defeating something undefeatable.
"You know books are different than real life, because the author gets to make up the story, and decides what happens to the characters in it," I said. "I know," he said, but still wanted to read the story with me every night before he went to bed.
I think of it now as his first introduction to the mind of an artist, and how art can sometimes triumph over harsh realities. As a boy, Josh's imagination soared over the world as it was, making me remember the imaginary friends and animals I had as a child. I began to think if one could pass on traits like hair and eye color, maybe one could (and did) also pass on artistic inclinations and a certain way of seeing life.
When I wrote The Beat on Ruby's Street, I began putting together bits and pieces of my own childhood and then glommed on to the one I'd always wanted. I was raised in suburban New Jersey but never felt I belonged there. The streets of Manhattan, pulsing with hippies when I was a child and punk rockers when I returned after college, seemed closer to the kind of world I was looking for.
Though I did not grow up during the "Beat Generation" era, I always thought the poets and artists of 1950s Greenwich Village paved the way for the hippies, rebels, punk rockers and rule breakers of the future. When everyone else was falling in step with two-car garages and Mad-Men lifestyles, Beats were trying to wean themselves away from materialism and superficial attachments.
They were accused of being spoiled children who refused to buckle down and work—but if you read their books and poetry, you see a different story. It recognizes that yes, life can be beautiful and joyful—but it also has all kinds of curve balls waiting to trip you up, and there is no real way to solve them. If you are here, on this earth, chances are you will hopefully have fun, but you are also going to suffer. And suffering is useless unless it is transformative—and that's what art has the power to give us.
The Beat on Ruby's Street brings us into the teeming, complicated life of a young girl whose world falls apart despite her frantic efforts to keep it together. Coming of age and coming out of it is only possible because she is able to find her own voice through the tumultuous, messy, artistic minds around her. It is a journey we all take in one way or another, but whether we are artists or not doesn't matter. In the end, I think art can help us get through what might otherwise be unbearable.
Josh: family photo


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It is about eight-meter-high bamboo poles, festooned with bamboo decorations, which arch over roadways or pathways during Galungan or other important occasions. Whenever you see this fertility symbol, it means there's some sort of celebration or ceremony about to happen or being held nearby.
The arched top represents Gunung Agung, the body is a river that flows from the mountains to the sea, and along its route are the products of the harvest, tied to the pole; at the foot of the pole is a temporary shrine.


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Conway, SC - CONWAY, SC (WMBF) - J. Ralph Byington has been named dean of the E. Craig Wall Sr. College of Business Administration at Coastal Carolina University, effective July 1.
CCU Provost Robert Sheehan announced the new appointment following approval by the board of trustees today.
The dean serves as the chief administrative officer of the college with responsibility for budget, personnel matters, planning and scheduling course offerings, fundraising and guidance of the College's educational offerings.
Byington is dean of the School of Business Administration at the University of South Carolina-Aiken, where he served since 2003. He also spent eight years as associate dean and director of the School of Accountancy at Georgia Southern University. He has served as a faculty member at Louisiana Tech University and Texas Tech University and taught as a graduate student at the University of Arkansas.
He has been recognized for his activities at three universities, receiving the New Faculty Excellence Award from Texas Tech, the College of Business Administration Professor of the Year at Louisiana Tech, as well as three separate outstanding faculty and professorial awards at Georgia Southern.
Byington has had experience in state government and in the business world. He was director and internal auditor at the University of Southern Mississippi (USM), and he was an investigator for the PEER Committee for the state of Mississippi. He was also chief fiscal officer for the Mississippi Governor's Office for Federal Programs.
His publications include more than 130 journal articles, book chapters, newsletter items and proceedings. At the 1996 national meeting of the American Accounting Association, he and a co-author received the Notable Contributions to the Information Systems/Management Advisory Services Literature Award. In 1995, he received the Southwest Federation of Administrative Disciplines Distinguished Paper Award in the accounting area.
Byington is a member of numerous professional organizations and was president of the Southeast chapter of the American Accounting Association and president of the Southeast chapter of the Georgia Society of CPAs.
He has made more than 250 presentations to business executives, CPA societies, student organizations and public accounting firms in 12 states.
Byington earned a bachelor's degree and a master's degree from the University of Southern Mississippi and a doctorate in accounting from the University of Arkansas; he is also a certified public accountant.
Copyright 2010 WMBF News. All rights reserved.


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The high complexity and dynamic nature of the regulation of gene expression, protein synthesis, and protein activity pose a challenge to fully understand the cellular machinery. By deciphering the role of important players, including transcription factors, microRNAs, or small molecules, a better understanding of key regulatory processes can be obtained. Various databases contain information on the interactions of regulators with their targets for different organisms, data recently being extended with the results of the ENCODE (Encyclopedia of DNA Elements) project. A systems biology approach integrating our understanding on different regulators is essential in interpreting the regulation of molecular biological processes.
We developed CyTargetLinker (http://projects.bigcat.unimaas.nl/cytargetlinker), a Cytoscape app, for integrating regulatory interactions in network analysis. Recently we released CyTargetLinker as one of the first apps for Cytoscape 3. It provides a user-friendly and flexible interface to extend biological networks with regulatory interactions, such as microRNA-target, transcription factor-target and/or drug-target. Importantly, CyTargetLinker employs identifier mapping to combine various interaction data resources that use different types of identifiers.
Three case studies demonstrate the strength and broad applicability of CyTargetLinker, (i) extending a mouse molecular interaction network, containing genes linked to diabetes mellitus, with validated and predicted microRNAs, (ii) enriching a molecular interaction network, containing DNA repair genes, with ENCODE transcription factor and (iii) building a regulatory meta-network in which a biological process is extended with information on transcription factor, microRNA and drug regulation.
CyTargetLinker provides a simple and extensible framework for biologists and bioinformaticians to integrate different regulatory interactions into their network analysis approaches. Visualization options enable biological interpretation of complex regulatory networks in a graphical way. Importantly the incorporation of our tool into the Cytoscape framework allows the application of CyTargetLinker in combination with a wide variety of other apps for state-of-the-art network analysis.
Citation: Kutmon M, Kelder T, Mandaviya P, Evelo CTA, Coort SL (2013) CyTargetLinker: A Cytoscape App to Integrate Regulatory Interactions in Network Analysis. PLoS ONE 8(12): e82160. https://doi.org/10.1371/journal.pone.0082160
Editor: Julio Vera, University of Erlangen-Nuremberg, Germany
Received: August 22, 2013; Accepted: October 25, 2013; Published: December 5, 2013
Copyright: © 2013 Kutmon et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding: This work was (co)financed by the Netherlands Consortium for Systems Biology (NCSB) which is part of the Netherlands Genomics Initiative/Netherlands Organisation for Scientific Research (http://www.ncsb.org). No additional external funding was received for this study. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing interests: The authors have declared that no competing interests exist.
Completion of the human genome project in 2003 generated a wealth of information about the human genetic code [1]. Approximately 25,000 gene coding regions were defined. However, understanding of the regulation of gene expression, protein synthesis and activity is far from complete. Recently, the ENCODE project, whose main goal was to identify all the functional elements in the human genome sequence, revealed novel insights in genetic regulation [2], [3]. It still remains a challenge to combine the new insights with existing knowledge and to understand the regulation of biological processes in detail. Many known biological processes are represented in various online repositories, like WikiPathways [4] and Reactome [5]. These processes contain genes, proteins and/or metabolites, their molecular interactions and reactions, but little regulatory information is present.
Regulation of gene expression, protein synthesis and activity occurs at different levels. Whereas gene expression is influenced by epigenetic factors and/or transcription factor (TF) binding, protein synthesis can be regulated by microRNAs (miRNAs). TFs are proteins that bind to a specific DNA sequence, i.e., the transcription factor binding site (TFBS). They either activate or repress transcription. miRNAs are small, non-coding RNA molecules that bind to miRNA-target regions in the mRNA. Upon binding miRNAs either repress translation or cleave the mRNA sequence. They are able to influence the synthesis of many proteins or even those involved in entire pathways, making them important molecules in harmonised regulation. Another group of regulatory effects are post-translational modifications which can influence protein activity. These modifications include phosphorylation, acetylation, palmitoylation and many more. In addition, small molecules such as metabolites or drugs can play a role as regulators in cellular pathways.
A systems biology approach in which interactions from different resources are combined, visualised and analysed together is an intuitive way to decipher complex biological processes. A commonly used framework to visualise and analyse biological networks is Cytoscape [6]. Its modular structure and possibilities to extend with additional functionalities through apps (formerly known as plugins) is discussed in "A travel guide to Cytoscape plugins" [7]. At the moment a few Cytoscape apps are available that either extend networks with other types of molecular interaction data or focus on one specific type of regulatory interaction. However, a user-friendly tool to combine and integrate various types of regulation is still needed. In this paper, we present a new Cytoscape app, CyTargetLinker, to automatically add regulatory interactions to biological networks to allow their inclusion in the network analysis process. CyTargetLinker is not restricted to one specific organism or regulatory interaction type and it leaves the selection of relevant and/or preferred interaction databases entirely to the user. The incorporation of our tool into the Cytoscape framework allows its application in combination with several community-contributed apps for data visualization and advanced network analysis.
CyTargetLinker is an open source app developed for the network visualization and analysis tool Cytoscape [6] and can be installed through the app manager in Cytoscape 2.8 or 3.x. The source code is available on Github (https://github.com/mkutmon/cytargetlinker).
CyTargetLinker allows users to build regulatory networks to obtain a more complete view of biological systems. The regulatory interactions used in CyTargetLinker are derived from so called regulatory interaction networks (RegINs) that are either provided on the CyTargetLinker website or can be created by the user. The creation, application and content of RegINs is explained below. All functionalities of CyTargetLinker are described in the "CyTargetLinker workflow" section.
Regulatory interaction networks
A RegIN is a network containing regulatory interactions that are often derived from online interaction databases. The networks are stored in XGMML (the eXtensible Graph Markup and Modelling Language) format, which is supported by Cytoscape. Each regulatory interaction consists of two nodes, a source (regulatory component) and target biomolecule, connected through one directed edge. A collection of RegINs for different species and interaction types is provided on the CyTargetLinker website (http://projects.bigcat.unimaas.nl/cytargetlinker/regins), and is described in more details in Table 1. In addition, we provide documentation on how to create your own RegIN (see supporting information, File S1). The app is not restricted to the RegINs provided and the user can choose which interaction types and databases should be used in the integration process.
A set of RegINs can be seen as a collection of online interaction databases that are formatted in the same way so they can be combined in the integration and analysis process. For the available RegINs, in order to be able to jointly use them, one unifying identifier system was used: the Ensembl gene identifier [8] was chosen for genes, the miRBase [9] accession number for miRNAs and DrugBank [10] identifiers for drugs. The identifier mapping was performed using the BridgeDb mapping framework [11]. In addition to the main identifier system, the RegINs contain additional systems (e.g. NCBI gene [12] and UniProt [13] for genes/proteins) to give the user more freedom to choose the identifier system in the initial network which has to match to that used in the RegIN. In case the identifier system is not supported by the RegINs to be used, the user can use the CyThesaurus [11] app in Cytoscape to map the identifiers to one of the supported systems.
CyTargetLinker workflow
CyTargetLinker enables the enrichment of biological networks with regulatory information in a user-friendly and flexible manner. The CyTargetLinker workflow will now be discussed in detail and is illustrated by an example in Figure 1.
Step 1: Four miRNAs known to be involved in prostate cancer [27] are visualised in a Cytoscape network (A). The miRNAs are annotated with miRBase accession numbers and ids. Step 2: The regulatory interaction networks (RegINs) harbouring miRNA-target interactions (MTIs), either validated (miRecords and miRTarBase) or predicted (microCosm and TargetScan), are downloaded from http://projects.bigcat.unimaas.nl/cytargetlinker/regins. Step 3: Known targets are integrated (B) after specifying the miRBase accession number column, the RegINs directory and the direction "Add Targets" in the CyTargetLinker dialog. In the resulting network miRNAs and target genes are defined as grey circles and pink hexagons, respectively. The predicted MTIs are visualised in orange (TargetScan: 4239) and blue (microCosm: 2800) and the validated MTIs in red (miRTarBase: 59) and purple (miRecords: 24), as shown in the control panel. Step 4: The hide/show and overlap threshold functions were used to visualise validated interactions exclusively or to show the overlap in MTI coverage. In the validated network only the MTIs in miRecords and miRTarBase are visualised by hiding MTIs in TargetScan and microCosm (C). In the overlap network the MTIs present in two or more RegINs are shown by setting the threshold to 2 (D).
The first step is to load or create a biological network in Cytoscape. Starting from a protein-protein network, a biological pathway or unconnected gene nodes, the initial network that will be extended with regulatory information can be very different. In each case the elements in the network should be annotated using one of the supported identifier systems. The second step is to download or create RegINs, as described in the next section. In the third step the CyTargetLinker integration process is started in Cytoscape. In the dialog the user selects the biological network, the node identifier attribute and the local directory containing the downloaded RegIN files. Thereafter, the direction of the interaction should be selected. It is possible to only add targets, regulators or both (default). CyTargetLinker will extract only those regulatory interactions from the provided RegINs, in which one of the nodes in the initial network is a participant, either regulator or target. This reduces the amount of memory needed, speeds up the integration process, and makes CyTargetLinker scalable to large regulatory networks.
After the extension of the network the initial network nodes are visualised as grey circles whereas the added nodes are shown as pink hexagons (see Figure 1B). Moreover, the edge colour defines in which RegIN an interaction is present. If an interaction is supported by more than one RegIN, CyTargetLinker will add one differently coloured edge for each RegIN. In the accompanying control panel the interaction colour can be changed and the number of added interactions per RegIN is listed. In the fourth step the visualization of the regulatory network can be adapted by using the hide/show and/or overlap threshold function. The hide/show functionality enables the temporary removal of specific RegINs and thereby showing only the interactions from a subset of the loaded RegINs (see Figure 1C). The overlap threshold functionality makes it possible to show only the interactions that are supported by a defined number of RegINs or more (see Figure 1D). Both functions can be applied and restored in the same network window.
The strength and broad applicability of CyTargetLinker will be demonstrated by three different case studies. In these studies the currently available RegINs will be used for extending biological networks. In Table 1, a subset of the downloadable RegINs present at the CyTargetLinker website is shown. The RegINs are generated from the latest database version and will be updated once a new version is available and accessible. The older versions will stay available in an archive.
Use cases
Case study 1 - Enrichment of a mouse molecular interaction network, containing genes linked to diabetes mellitus, with miRNA information. The first case study demonstrates that CyTargetLinker is not limited to human networks, but can be used for other species as well. The threshold functionality is applied to show only interactions that are supported by at least two miRNA-target interaction (MTI) databases.
Diabetes mellitus is a group of metabolic diseases. The two major types are type 1 and type 2 which are characterised by impaired insulin production or insulin resistance, respectively. Worldwide the prevalence of type 2 diabetes mellitus (T2DM) is increasing dramatically. Although a strong environmental component is present, there is compelling evidence that genetic factors are involved in the pathogenesis of T2DM [14]. It is important to decipher the genes involved and to understand their regulation. Diabetic mouse models are often used to measure gene expression on a large scale in tissues like adipose, skeletal muscle and liver. The genes linked to diabetes mellitus can be functionally annotated using the terms in the disease category of MeSH (Medical Subject Headings) [15]. CyTargetLinker can be used to examine the possible role of miRNA regulation of genes known to be linked to diabetes mellitus.
A mouse molecular interaction network of genes linked to the MeSH term diabetes mellitus was obtained from Gene2MeSH [16] and the STRING database [17]. In total 18 proteins are associated with diabetes mellitus and are known to interact with each other (see supporting information, File S2). To get a better insight in how the genes are regulated by miRNAs, validated and predicted miRNAs were added and the overlap of the MTIs present in two or more databases was selected with CyTargetLinker (see Figure 2). After applying overlap threshold, 50 MTIs remain in the extended network originating from miRecords (1), miRTarBase (2), microCosm (24) and TargetScan (25). In the extended molecular interaction network only 6 out of 18 genes interact with mostly predicted miRNAs that were present in 2 or more interaction databases. Whereas LEPR (leptin receptor) and SLC2A2 (GLUT2) interact with only one miRNA, INSR (insulin receptor) and PPARa (peroxisomal proliferator activated receptor alpha) are highly regulated by 7 and 10 miRNAs, respectively. It is well known that the activation of the nuclear receptor, PPARalpha, has beneficial effects in T2DM. PPAR agonists are used as antidiabetic drugs to treat the symptoms of T2DM. Identifying which miRNAs interact with PPARalpha could lead to novel pharmacological targets. In this use case CyTargetLinker can be used to either identify miRNAs of interest or to confirm recent findings. For example, the regulation of PPARalpha by miR-21, present in the extended network, was published in 2011 in a liver study [18]. The other highly regulated gene, the insulin receptor, plays a key role in the insulin signalling pathway. Most miRNAs interacting with the insulin receptor in the extended network belong to the let-7 miRNA family (see Figure 2). Interestingly, Forst and Olson [19] showed that the let-7 family controls glucose homeostasis and insulin sensitivity in mice. Their study confirms that in liver and muscle the let-7 family regulates the insulin receptor as shown in the extended network.
Genes and miRNAs are visualised as grey circles and yellow rounded rectangles, respectively. The names of the genes and miRNAs are displayed on the nodes. The genes linked to the MeSH term diabetes mellitus were obtained using Gene2MeSH (http://gene2mesh.ncibi.org/). The molecular interactions between the genes were obtained from the STRING database and are visualised in black. The MTIs originate from microCosm (486), TargetScan (207), miRTarBase (5) and miRecords (2), and are coloured in blue, orange, red and purple, respectively.The overlap threshold function was applied to show only MTIs present in at least two RegINs.
Case study 2 - Extension with ENCODE TF regulation information of a molecular interaction network of human DNA repair genes and its analysis. The second case study demonstrates how CyTargetLinker can be applied in combination with other Cytoscape apps. Moreover, it shows that published regulatory interaction data can be easily converted into a RegIN and implemented into the CyTargetLinker workflow. By using the available core functionalities of Cytoscape is it possible to adjust the colour and size of a node and to perform commonly used network analyses in the extended network.
The ENCODE project aims to delineate all functional elements encoded in the human genome [2]. Since 2003 it has generated a wealth of information on regulatory elements. Gerstein and colleagues used the recently published TF binding data to analyse differential patterns in promoter proximal and distal regulatory regions [3]. TFs bind to specific sites, transcription factor binding sites (TFBS), that can be proximal or distal to a transcription start site [20]. Distinguishing these two types of TF-regulation gives a more distinctive view on how gene expression can be influenced.
We used the proximal and distal regulatory interaction data provided by Gerstein and generated RegINs for both. A set of known DNA repair genes were used as input for the GeneMANIA app [21] in Cytoscape to create a molecular interaction network (see supporting information, File S3). GeneMANIA identifies the most related genes to a query gene set using a guilt-by-association approach. With CyTargetLinker the DNA repair network was enriched with the two types of regulatory data. Next, we used Cytoscape's VizMapper to shape and colour the TF nodes according to their TF family. To identify the genes highly regulated by TFs, the indegree was calculated and represented as the size of the gene nodes, see Figure 3. From the network it is immediately clear that the H2AFX (H2A histone family, member X) gene is highly regulated by proximal TFs. Moreover, the NBN and MSH2 genes are regulated by both proximal and distal TFs.
A set of known DNA repair genes (grey circled nodes) were used as input for the GeneMania app in Cytoscape. Physical interactions (black) between the query genes were added by GeneMania. Every node in a GeneMania network has an attribute "Entrez gene identifier" which was used by the CyTargetLinker app to extend the network with TF-gene interactions from the ENCODE networks. The integration direction was selected as "Add regulators", indicating that the app should look for interactions that target the input genes. The colours and shapes of the TFs are based on the provided TF family information in the ENCODE project [3]. The ENCODE project studied proximal and distal TF regulation which are indicated in this figure as blue and red edges.
Case study 3 - Enrichment of a human pathway from WikiPathways with miRNAs, TFs and drugs targeting the genes and gene products in the pathway. Case study 3 highlights the power of CyTargetLinker to build an extensive regulatory interaction network integrating a wide range of known interactions. This network can be used as a starting point for various network analysis approaches to filter out regulatory interactions that are relevant in a given context. The integration of different regulatory elements together allows the researcher to get a more complete view of possible regulatory mechanisms happening in a biological process.
The initial network represents the ErbB signaling pathway which was loaded through the WikiPathways web service provided by the GPML app [22] (see supporting information, File S4). Insufficient ErbB signaling may cause the development of neurodegenerative diseases, such as multiple sclerosis and Alzheimer's disease. Furthermore, excessive ErbB signaling is associated with the development of various types of solid tumours [23]. The pathway contains 69 genes, proteins and metabolites (plus 13 group nodes representing grouped genes or proteins in the original pathway diagram) and 93 edges. The network was extended with three different types of regulatory interactions, (i) drug-target interactions from DrugBank, (ii) proximal and distal TF-gene interactions from ENCODE and (iii) validated miRNA-target interactions from miRTarBase and miRecords, see Figure 4. In total, 558 regulatory interactions were integrated in the network, including 138 drug-target, 136 proximal TF-gene, 122 distal TF-gene and 162 validated miRNA-target interactions.
The ErbB signaling pathway (http://wikipathways.org/index.php/Pathway:WP673) from WikiPathways was extended with TFs, miRNAs and drugs regulating the elements in the pathway. The nodes from the original pathway are coloured in grey, TFs in green, miRNAs in yellow and drugs in purple. 258 TF-gene interactions from ENCODE, 162 miRNA-target interactions from the two validated miRNA-target RegINs (miRTarBase and miRecords) and 138 drug-target interactions from DrugBank were added to the network. The edges are coloured based on the RegIN source, purple and orange for ENCODE (proximal and distal), blue and red for miRTarBase and miRecords, and green for DrugBank.
There are a few nodes that are mostly targeted by drugs, e.g. GSK3 or SRC and other nodes that are targeted by all types of regulators, e.g. ERK or HRAS. In terms of transcription factor regulation, some nodes are regulated in a proximal setting, e.g. ERK or ABL and others mostly in a distal way, e.g. ERBB3 or STAT5. Some TFs regulate different genes in different ways, e.g. TCF12 regulates FAK distal and SRC proximal. Since a few TFs were already present in the initial network, typical network motifs can be found, e.g. four feed forward loops regulating ERBB3 over Myc by CTCF, SMC3, RAD21 and GATA2. In this integration process the direction was set to include only regulators, so the target genes of MYC and JUN, two major TFs that are present in the pathway, are not added.
Related to miRNAs our analysis shows that p21 is mostly regulated by miRNAs and all the interactions are experimentally validated (references provided in edge attributes). Furthermore with the overlap threshold functionality, it can be visualised that only 30 out of 130 miRNA-target interactions are present in both miRTarbase and miRecords.
CyTargetLinker enables quick and extensive enrichment of biological networks with regulatory information. It encapsulates all the manual integration steps which include several tasks that require advanced programming knowledge. Therefore it can be used by researchers from different fields with or without prior knowledge in programming and network analysis. CyTargetLinker is open source and freely available through the app manager for Cytoscape 2.8 and 3.x. As mentioned in the introduction, there are a few other Cytoscape apps that provide partial similar functionality. miRScape, CluePedia [24], ConReg, and BioNetBuilder [25] are most related to CyTargetLinker, see Table 2.
miRScape identifies function, disease or process associations between genes by using miRNA-target information. CluePedia integrates experimental data to identify gene interrelations revealed by correlation weights, miRNAs regulatory aspects, protein-protein interactions as well as the functional context, in conjunction with ClueGO [26]. ConReg visualises TF-target gene networks with data from regulatory databases, text-mining approaches and TFBS predictions. It stores regulatory relations for 8 model organisms and investigates their level of conservation in related species. Lastly, BioNetBuilder focusses on the creation of biological networks using interaction data from DIP, BIND, Prolinks, KEGG, HPRD, BioGrid and GO.
BioNetBuilder and miRScape have not been maintained since version Cytoscape 2.6 (released in 2010). While CluePedia is also available as a Cytoscape 3.x app, it requires a license key. CyTargetLinker is generic and does not focus on one specific regulatory interaction type like miRScape and CluePedia. ConReg focuses only on TF-gene interactions, especially the conversion of regulatory relations in other eukaryotic model organisms and it produces a predicted conserved network. BioNetBuilder and CyTargetLinker can be used for several different species, however BioNetBuilder does not include regulatory interactions. While BioNetBuilder focusses on the creation of biological networks, CyTargetLinker extends biological networks with regulatory information. One of the advantages of the CyTargetLinker app is that it is easily expandable, a new RegIN can be added at any time and it is even possible to include a new interaction type without updating the app. Thereby, the user can use self-created RegINs in addition to the ones we provide and he can select the set of RegINs that are most suitable for his research focus. CyTargetLinker is an open source project which allows the contribution and input of other scientists to better tackle their research questions.
CyTargetLinker, our new Cytoscape app, enables scientists to integrate regulatory interactions into biological networks in a user-friendly and flexible manner. Various interactions, such as miRNA-target, TF-gene or drug-target, can be added, by themselves or combined. CyTargetLinker is not restricted to any organism and the commonly used identifiers for genes, proteins, and miRNAs are supported. The graphical representation in Cytoscape facilitates the identification of important regulatory interactions and can lead to new research hypotheses. The integration of CyTargetLinker into Cytoscape enables advanced network analysis and data visualization using functionality from other apps. This helps researchers to get a better understanding of the regulation of biological processes.
Future Developments
Future work, by us or other contributing groups, will include the development of new app features and conversion scripts for more publicly available databases, as well as allowing the connection to online graph databases (e.g. Neo4j) and RDF triple stores directly. This would even further simplify the integration process because the user does not need to download the RegINs beforehand.
Supporting Information
File S1.
Detailed description of the structure, content and creation of regulatory interaction networks (RegINs).
File S2.
Supporting information for case study 1 which is described in the results section. Description of the initial network of the use case and the overlap between the different miRNA-target databases for this use case.
File S3.
Supporting information for case study 2 which is described in the results section. Description of the initial network of the use case and more detailed information about the transcription factors, e.g. transcription factor families.
File S4.
Supporting information for case study 3 which is described in the results section. Contains the pathway diagram of the ErbB signaling pathway from WikiPathways.
We thank Lars Eijssen for his input on the manuscript. We thank Naïmé Douallin for her contributions to the project during her internship.
Author Contributions
Conceived and designed the experiments: MK TK CTE SLC. Analyzed the data: MK SLC. Wrote the paper: MK TK CTE SLC. Implemented the software described in the manuscript: MK TK PM.
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Help Me Recreate My Friend's Insane Holiday Treat
Q: I had a friend from the midwest who used to make this treat that consisted of covering popcorn with almond bark and while it was still hot, she would mix in M & Ms, candy corn, and pretzels. But, I'm not sure if I remember this correctly, therefore I'm not sure how to make this or even the name of this delicious snack. It was always something she made at the holidays and thinking back on it now, I would love to find a recipe for it. If anyone knows, I'd greatly appreciate it.
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In Re McInerney Homes Limited
In the McInerney case, the company and the examiner sought to have schemes confirmed which would result in an immediate payment to a banking syndicate of €25 million. The banking syndicate contended that the discounted current value which they expected to recover from their security outside any schemes was €50 million.
The banking syndicate's first line of argument was that the court could not confirm a scheme which imposed a reduction on the debt due to a secured creditor. This rather ambitious argument was dismissed by the court. The court found that the debt due to a secured creditor could be reduced under a scheme provided that the scheme was not unfairly prejudicial to the secured creditor. The court drew a distinction between the debt due to a secured creditor and the security held for that debt noting that in a scheme the debt could be reduced but the security could be left in place to secure the reduced debt.
However, the court also held that it would require exceptional circumstances before a court could approve a scheme of arrangement where secured creditors could be shown to be worse off under the scheme than under other methods by which the secured creditors could realise their security.
The balance of the case related to resolving the competing assessments of how the banking syndicate would in fact fare if the schemes were not confirmed. The banking syndicate estimated that it would recoup a current day value of approximately €50 million and therefore the offer under the schemes of €25 million was unfairly prejudicial whereas the company and the examiner contended that the bank would recoup only €11.9 million at present day value and therefore the €25 million offer was significantly better than the likely outturn on a receivership.
Much of the judgment was given over to the difficulties in assessing the competing evidence put forward as there was no cross-examination of the expert evidence which was presented on affidavit. Moreover, there are inherent difficulties in considering evidence of likely outturns which would be dependent on a wide variety of factors.
The court concluded that the evidence given by the banking syndicate established that it had a realistic prospect of doing better under the proposed receivership model than under the proposed schemes and accordingly the court refused to confirm the schemes.
This decision should dispel a number of persistent myths about the examinership process.
First, it removes any doubt regarding the ability of a scheme to write-down the debt due to a secured creditor (as distinct from interfering with its security).
Secondly, and most critically, it confirms that unless there are exceptional circumstances, the court will not approve a scheme where secured creditors will do worse than if they were permitted to realise their security in the ordinary way.
Thirdly, it shows that if the secured creditor can adduce evidence which allows the court to conclude that there is a credible basis for its position that it will do better outside a scheme, that should be sufficient to persuade the court not to confirm a scheme, even when faced with evidence to the contrary presented by the company and/or the examiner.