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Items where contributor is "Mäser, Pascal"
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Wiedemar, Natalie and Graf, Fabrice E. and Zwyer, Michaela and Ndomba, Emiliana and Kunz Renggli, Christina and Cal, Monica and Schmidt, Remo S. and Wenzler, Tanja and Mäser, Pascal. (2018) Beyond immune escape: a variant surface glycoprotein causes suramin resistance in Trypanosoma brucei. Molecular Microbiology, 107 (1). pp. 57-67.
Subramaniam, Suvitha and Schmid, Christoph D. and Guan, Xue Li and Mäser, Pascal. (2018) Using yeast synthetic lethality to inform drug combination for Malaria. Antimicrobial Agents and Chemotherapy, 62 (4). e01533-17.
Mohsin, N. U. A. and Seebacher, W. and Faist, J. and Kretschmer, N. and Bauer, R. and Saf, R. and Kaiser, M. and Mäser, P. and Weis, R.. (2018) Modifications on tetrahydropyridin-4-ylidene ammonium salts and their antiprotozoal activities. Monatshefte für Chemie, 149 (4). pp. 801-812.
Grogg, M. and Hilvert, D. and Ebert, M. O. and Beck, A. K. and Seebach, D. and Kurth, F. and Dittrich, P. S. and Sparr, C. and Wittlin, S. and Rottmann, M. and Mäser, P.. (2018) Cell penetration, herbicidal activity, and in-vivo-toxicity of oligo-arginine derivatives and of novel guanidinium-rich compounds derived from the biopolymer cyanophycin. Helvetica Chimica Acta, 101 (10). e1800112.
Mathieu, Christoph and Macêdo, Juan P. and Hürlimann, Daniel and Wirdnam, Corina and Haindrich, Alexander C. and Suter Grotemeyer, Marianne and González-Salgado, Amaia and Schmidt, Remo S. and Inbar, Ehud and Mäser, Pascal and Bütikofer, Peter and Zilberstein, Dan and Rentsch, Doris. (2017) Arginine and lysine transporters are essential for Trypanosoma brucei. PLoS ONE, 12. e0168775.
Faist, Johanna and Hinteregger, Clemens and Seebacher, Werner and Saf, Robert and Mäser, Pascal and Kaiser, Marcel and Weis, Robert. (2017) New derivatives of 7-chloroquinolin-4-amine with antiprotozoal activity. Bioorganic & medicinal chemistry, 25 (3). pp. 941-948.
Baumgärtner, Fabian and Jourdan, Joëlle and Scheurer, Christian and Blasco, Benjamin and Campo, Brice and Mäser, Pascal and Wittlin, Sergio. (2017) In vitro activity of anti-malarial ozonides against an artemisinin-resistant isolate. Malaria journal, 16. p. 45.
Dawidowski, M. and Emmanouilidis, L. and Kalel, V. C. and Tripsianes, K. and Schorpp, K. and Hadian, K. and Kaiser, M. and Mäser, P. and Kolonko, M. and Tanghe, S. and Rodriguez, A. and Schliebs, W. and Erdmann, R. and Sattler, M. and Popowicz, G. M.. (2017) Inhibitors of PEX14 disrupt protein import into glycosomes and kill Trypanosoma parasites. Science, 355 (6332). pp. 1416-1420.
Jeacock, Laura and Baker, Nicola and Wiedemar, Natalie and Mäser, Pascal and Horn, David. (2017) Aquaglyceroporin-null trypanosomes display glycerol transport defects and respiratory-inhibitor sensitivity. PLoS Pathogens, 13 (3). e1006307.
Steinmann, Michael E. and Schmidt, Remo S. and Bütikofer, Peter and Mäser, Pascal and Sigel, Erwin. (2017) TbIRK is a signature sequence free potassium channel from Trypanosoma brucei locating to acidocalcisomes. Scientific Reports, 7 (1). p. 656.
Seebacher, W. and Belaj, F. and Faist, J. and Saf, R. and Bucar, F. and Turek, I. and Branter, A. and Alajlani, M. and Kaiser, M. and Mäser, P. and Weis, R.. (2017) Synthesis of new pyrido-benzodiazepine salts and their antimicrobial activities. Monatshefte für Chemie, 148 (2). pp. 263-274.
Hochegger, Patrick and Faist, Johanna and Seebacher, Werner and Saf, Robert and Mäser, Pascal and Kaiser, Marcel and Weis, Robert. (2017) New derivatives of quinoline-4-carboxylic acid with antiplasmodial activity. Bioorganic & medicinal chemistry, 25 (7). pp. 2251-2259.
Mohsin, Noor-Ul-Amin and Seebacher, Werner and Faist, Johanna and Hochegger, Patrick and Kaiser, Marcel and Mäser, Pascal and Belaj, Ferdinand and Saf, Robert and Kretschmer, Nadine and Alajlani, Muaaz and Turek, Ivana and Brantner, Adelheid and Bauer, Rudolf and Bucar, Franz and Weis, Robert. (2017) Synthesis of new 1-benzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities. European journal of medicinal chemistry, 143. pp. 97-106.
Mäser, Pascal. (2017) Cherchez l'electron. Molecular microbiology, 106 (2). pp. 183-185.
Mohsin, N. U. A. and Seebacher, W. and Faist, J. and Hochegger, P. and Kaiser, M. and Mäser, P. and Saf, R. and Weis, R.. (2017) The antiplasmodial and antitrypanosomal activities of novel piperazine derivatives of 3-azabicyclo[3.2.2]nonanes. Monatshefte für Chemie, 149 (1). pp. 99-109.
Steinmann, Michael E. and Schmidt, Remo S. and Macêdo, Juan P. and Kunz Renggli, Christina and Bütikofer, Peter and Rentsch, Doris and Mäser, Pascal and Sigel, Erwin. (2017) Identification and characterization of the three members of the CLC family of anion transport proteins in Trypanosoma brucei. PLoS ONE, 12 (12). e0188219.
Guan, Xue Li and Mäser, Pascal. (2017) Comparative sphingolipidomics of disease-causing trypanosomatids reveal unique lifecycle- and taxonomy-specific lipid chemistries. Scientific reports, 7. p. 13617.
Jourdan, Joëlle and Hugues, Matile and Reift, Ellen and Biehlmaier, Oliver and Dong, Yuxiang and Wang, Xiaofang and Mäser, Pascal and Vennerstrom, Jonathan and Wittlin, Sergio. (2016) Monoclonal antibodies that recognize the alkylation signature of antimalarial ozonides OZ277 (Arterolane) and OZ439 ( Artefenomel). ACS infectious diseases, 2 (1). pp. 54-61.
Wenzler, Tanja and Schumann Burkard, Gabriela and S. Schmidt, Remo and Mäser, Pascal and Bergner, Andreas and Roditi, Isabel and Brun, Reto. (2016) A new approach to chemotherapy : drug-induced differentiation kills African trypanosomes. Scientific Reports, 6. p. 22451.
Wang, Tai and Mäser, Pascal and Picard, Didier. (2016) Inhibition of Plasmodium falciparum Hsp90 contributes to the antimalarial activities of aminoalcohol-carbazoles. Journal of Medicinal Chemistry, 59 (13). pp. 6344-6352.
Graf, Fabrice E. and Ludin, Philipp and Arquint, Christian and Schmidt, Remo S. and Schaub, Nadia and Kunz Renggli, Christina and Munday, Jane C. and Krezdorn, Jessica and Baker, Nicola and Horn, David and Balmer, Oliver and Caccone, Adalgisa and de Koning, Harry P. and Mäser, Pascal. (2016) Comparative genomics of drug resistance in Trypanosoma brucei rhodesiense. Cellular and molecular life sciences, 73 (17). pp. 3387-3400.
Shameer, Sanu and Logan-Klumpler, Flora J. and Vinson, Florence and Cottret, Ludovic and Merlet, Benjamin and Achcar, Fiona and Boshart, Michael and Berriman, Matthew and Breitling, Rainer and Bringaud, Frédéric and Bütikofer, Peter and Cattanach, Amy M. and Bannerman-Chukualim, Bridget and Creek, Darren J. and Crouch, Kathryn and de Koning, Harry P. and Denise, Hubert and Ebikeme, Charles and Fairlamb, Alan H. and Ferguson, Michael A. J. and Ginger, Michael L. and Hertz-Fowler, Christiane and Kerkhoven, Eduard J. and Mäser, Pascal and Michels, Paul A. M. and Nayak, Archana and Nes, David W. and Nolan, Derek P. and Olsen, Christian and Silva-Franco, Fatima and Smith, Terry K. and Taylor, Martin C. and Tielens, Aloysius G. M. and Urbaniak, Michael D. and van Hellemond, Jaap J. and Vincent, Isabel M. and Wilkinson, Shane R. and Wyllie, Susan and Opperdoes, Fred R. and Barrett, Michael P. and Jourdan, Fabien. (2015) TrypanoCyc : a community-led biochemical pathways database for Trypanosoma brucei. Nucleic Acids Research, 43 (D1). D637-D644.
de Macêdo, Juan P. and Schumann Burkard, Gabriela and Niemann, Moritz and Barrett, Michael P. and Vial, Henri and Mäser, Pascal and Roditi, Isabel and Schneider, André and Bütikofer, Peter. (2015) An atypical mitochondrial carrier that mediates drug action in Trypanosoma brucei. PLoS Pathogens, Vol. 11, H. 5 , e1004875.
Witschel, Matthias C. and Rottmann, Matthias and Schwab, Anatol and Leartsakulpanich, Ubolsree and Chitnumsub, Penchit and Seet, Michael and Tonazzi, Sandro and Schwertz, Geoffrey and Stelzer, Frank and Mietzner, Thomas and McNamara, Case and Thater, Frank and Freymond, Céline and Jaruwat, Aritsara and Pinthong, Chatchadaporn and Riangrungroj, Pinpunya and Oufir, Mouhssin and Hamburger, Matthias and Mäser, Pascal and Sanz-Alonso, Laura M. and Charman, Susan and Wittlin, Sergio and Yuthavong, Yongyuth and Chaiyen, Pimchai and Diederich, François. (2015) Inhibitors of plasmodial serine hydroxymethyltransferase (SHMT) : co-crystal structures of pyrazolopyrans with potent blood-and liver-stage activities. Journal of Medicinal Chemistry, 58 (7). pp. 3117-3130.
Graf, Fabrice E. and Baker, Nicola and Munday, Jane C. and de Koning, Harry P. and Horn, David and Mäser, Pascal. (2015) Chimerization at the AQP2-AQP3 locus is the genetic basis of melarsoprol-pentamidine cross-resistance in clinical Trypanosoma brucei gambiense isolates. International journal for parasitology. Drugs and drug resistance, Vol. 5, H. 2. pp. 65-68.
Kaiser, Marcel and Mäser, Pascal and Tadoori, Leela Pavan and Ioset, Jean-Robert and Brun, Reto. (2015) Antiprotozoal activity profiling of approved drugs : a starting point toward drug repositioning. PLoS ONE, Vol. 10, H. 8 , e0135556.
Steinmann, Michael E. and González-Salgado, Amaia and Bütikofer, Peter and Mäser, Pascal and Sigel, Erwin. (2015) A heteromeric potassium channel involved in the modulation of the plasma membrane potential is essential for the survival of African trypanosomes. The FASEB journal, Vol. 29, H. 8. pp. 3228-3237.
Munday, Jane C. and Eze, Anthonius A. and Baker, Nicola and Glover, Lucy and Clucas, Caroline and Aguinaga Andrés, David and Natto, Manal J. and Teka, Ibrahim A. and McDonald, Jennifer and Lee, Rebecca S. and Graf, Fabrice E. and Ludin, Philipp and Burchmore, Richard J. S. and Turner, C. Michael R. and Tait, Andy and MacLeod, Annette and Mäser, Pascal and Barrett, Michael P. and Horn, David and De Koning, Harry P.. (2014) Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs. The journal of antimicrobial chemotherapy, Vol. 69, H. 3. pp. 651-663.
Wang, Tai and Bisson, William H. and Mäser, Pascal and Scapozza, Leonardo and Picard, Didier. (2014) Differences in conformational dynamics between Plasmodium falciparum and human Hsp90 orthologues enable the structure-based discovery of pathogen-selective inhibitors. Journal of medicinal chemistry, 57 (6). pp. 2524-2535.
Lüscher, Alexandra and Lamprea-Burgunder, Estelle and Graf, Fabrice E. and de Koning, Harry P. and Mäser, Pascal. (2014) Trypanosoma brucei adenine-phosphoribosyltransferases mediate adenine salvage and aminopurinol susceptibility but not adenine toxicity. International journal for parasitology : drugs and drug resistance, Vol. 4, H. 1. pp. 55-63.
Fügi, Matthias A. and Gunasekera, Kapila and Ochsenreiter, Torsten and Guan, Xueli and Wenk, Markus R. and Mäser, Pascal. (2014) Genome profiling of sterol synthesis shows convergent evolution in parasites and guides chemotherapeutic attack. Journal of Lipid Research, 55 (5). pp. 929-938.
Mathieu, Christoph and Salgado, Amaia González and Wirdnam, Corina and Meier, Stefan and Grotemeyer, Marianne Suter and Inbar, Ehud and Mäser, Pascal and Zilberstein, Dan and Sigel, Erwin and Bütikofer, Peter and Rentsch, Doris. (2014) Trypanosoma brucei eflornithine transporter AAT6 is a low-affinity low-selective transporter for neutral amino acids. Biochemical journal, Vol. 463, Pt. 1. pp. 9-18.
Sistrom, Mark and Evans, Benjamin and Bjornson, Robert and Gibson, Wendy and Balmer, Oliver and Mäser, Pascal and Aksoy, Serap and Caccone, Adalgisa. (2014) Comparative genomics reveals multiple genetic backgrounds of human pathogenicity in the Trypanosoma brucei complex. Genome biology and evolution, Vol. 6, H. 10. pp. 2811-2819.
Fügi, Matthias A. and Kaiser, Marcel and Tanner, Marcel and Schneiter, Roger and Mäser, Pascal and Guan, Xue Li. (2014) Match-making for posaconazole through systems thinking. Trends in parasitology, Vol. 31, H. 2. pp. 46-51.
Ali, J. A. M. and Creek, D. J. and Burgess, K. and Allison, H. C. and Field, M. C. and Mäser, P. and de Koning, H. P.. (2013) Pyrimidine salvage in Trypanosoma brucei bloodstream forms and the trypanocidal action of halogenated pyrimidines. Molecular pharmacology : an international journal, Vol. 83, H. 2. pp. 439-453.
Baker, Nicola and de Koning, Harry P. and Mäser, Pascal and Horn, David. (2013) Drug resistance in African trypanosomiasis: the melarsoprol and pentamidine story. Trends in parasitology, Vol. 29, H. 3. pp. 110-118.
Graf, Fabrice E. and Ludin, Philipp and Wenzler, Tanja and Kaiser, Marcel and Brun, Reto and Pyana, Patient Pati and Büscher, Philippe and de Koning, Harry P. and Horn, David and Mäser, Pascal. (2013) Aquaporin 2 mutations in Trypanosoma brucei gambiense field isolates correlate with decreased susceptibility to pentamidine and melarsoprol. PLoS neglected tropical diseases, Vol. 7, H. 10 , e2475.
Greganova, Eva and Steinmann, Michael and Mäser, Pascal and Fankhauser, Niklaus. (2013) In silico ionomics segregates parasitic from free-living eukaryotes. Genome biology and evolution, Vol. 5, H. 10. pp. 1902-1909.
Macêdo, Juan P. and Schmidt, Remo S. and Mäser, Pascal and Rentsch, Doris and Vial, Henri J. and Sigel, Erwin and Bütikofer, Peter. (2013) Characterization of choline uptake in Trypanosoma brucei procyclic and bloodstream forms. Molecular & biochemical parasitology, Vol. 190, H. 1. pp. 16-22.
Mäser, P. and Wittlin, S. and Rottmann, M. and Wenzler, T. and Kaiser, M. and Brun, R.. (2012) Antiparasitic agents : new drugs on the horizon. Current opinion in pharmacology, Vol. 12, H. 5. pp. 562-566.
Ludin, Philipp and Woodcroft, Ben and Ralph, Stuart A. and Maeser, Pascal. (2012) In silicio prediction of antimalarial drug target candidates. International journal for parasitology: drugs and drug resistance, Vol. 2. pp. 191-199.
Gonzalez-Salgado, A. and Steinmann, M. E. and Greganova, E. and Rauch, M. and Mäser, P. and Sigel, E. and Bütikofer, P.. (2012) myo-inositol uptake is essential for bulk inositol phospholipid but not glycosylphosphatidylinositol synthesis in Trypanosoma brucei. Journal of biological chemistry, Vol. 287, H. 16. pp. 13313-13323.
Godel, C. and Kumar, S. and Koutsovoulos, G. and Ludin, P. and Nilsson, D. and Comandatore, F. and Wrobel, N. and Thompson, M. and Schmid, C. D. and Goto, S. and Bringaud, F. and Wolstenholme, A. and Bandi, C. and Epe, C. and Kaminsky, R. and Blaxter, M. and Mäser, P.. (2012) The genome of the heartworm, Dirofilaria immitis, reveals drug and vaccine targets. The FASEB Journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 26, H. 11. pp. 4650-4661.
Oehring, S. C. and Woodcroft, B. J. and Moes, S. and Wetzel, J. and Dietz, O. and Pulfer, A. and Dekiwadia, C. and Maeser, P. and Flueck, C. and Witmer, K. and Brancucci, N. M. and Niederwieser, I. and Jenoe, P. and Ralph, S. A. and Voss, Till S.. (2012) Organellar proteomics reveals hundreds of novel nuclear proteins in the malaria parasite Plasmodium falciparum. Genome biology, Vol. 13, H. 11 , R108.
Teka, I. A. and Kazibwe, A. J. N. and El-Sabbagh N., and Al-Salabi M. I., and Ward, C. P. and Eze, A. A. and Munday, J. C. and Mäser, P. and Matovu, E. and Barrett, M. P. and de Koning H. P., . (2011) The diamidine diminazene aceturate is a substrate for the high-affinity pentamidine transporter: implications for the development of high resistance levels in trypanosomes. Molecular pharmacology : an international journal, Vol. 80, H. 1. pp. 110-116.
Lamprea-Burgunder, E. and Ludin, P. and Mäser, P.. (2011) Species-specific typing of DNA based on palindrome frequency patterns. DNA research, 18 (2). pp. 117-124.
Ludin, P. and Nilsson, D. and Mäser, P.. (2011) Genome-wide identification of molecular mimicry candidates in parasites. PLoS ONE, 6 (3). e17546.
Rufener, L. and Keiser, J. and Kaminsky, R. and Mäser, P. and Nilsson, D.. (2010) Phylogenomics of ligand-gated ion channels predicts monepantel effect. PLoS Pathogens, Vol. 6, H. 9 , e1001091.
Mosimann, M. and Goshima, S. and Wenzler, T. and Luscher, A. and Uozumi, N. and Mäser, P.. (2010) A Trk/HKT-type K+ transporter from Trypanosoma brucei. Eukaryotic Cell, Vol. 9, H. 4. pp. 539-546.
Rufener, L. and Baur, R. and Kaminsky, R. and Mäser, P. and Sigel, E.. (2010) Monepantel allosterically activates DEG-3/DES-2 channels of the gastrointestinal nematode Haemonchus contortus. Molecular pharmacology : an international journal, Vol. 78, H. 5. pp. 895-902.
Nerima, B. and Nilsson, D. and Mäser, P.. (2010) Comparative genomics of metabolic networks of free-living and parasitic eukaryotes. BMC Genomics, Vol. 11 , 217.
Kuettel, S. and Mosimann, M. and Mäser, P. and Kaiser, M. and Brun, R. and Scapozza, L. and Perozzo, R.. (2009) Adenosine kinase of T. b. Rhodesiense identified as the putative target of 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine using chemical proteomics. PLoS Neglected Tropical Diseases, Vol. 3, H. 8 , e506.
Maina, Naomi and Maina, Kagira Joseph and Mäser, Pascal and Brun, Reto. (2007) Genotypic and phenotypic characterization of Trypanosoma brucei gambiense isolates from Ibba, South Sudan, an area of high melarsoprol treatment failure rate. Acta tropica : Zeitschrift für Tropenwissenschaften und Tropenmedizin = revue des sciences tropicales et de médecine tropicale = review of tropical science and tropical medicine, 104 (2-3). pp. 84-90.
Bernhard, Sonja C. and Nerima, Barbara and Mäser, Pascal and Brun, Reto. (2007) Melarsoprol- and pentamidine-resistant Trypanosoma brucei rhodesiense populations and their cross-resistance. International journal for parasitology, Vol. 37, H. 13. pp. 1443-1448.
Mäser, Pascal and Grether-Bühler, Yvonne and Kaminsky, Ronald and Brun, Reto. (2002) An anti-contamination cocktail for the in vitro isolation and cultivation of parasitic protozoa. Parasitology research : Organ der Deutschen Gesellschaft für Parasitologie, Vol. 88, H. 2. pp. 172-174.


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There has been some talk lately about my generation (the millenials and generation Y). Is the Internet making us genius or completely incapable of making smart decisions (dumb)?
I do not know where my opinion falls on the subject. I have had contact with brilliant Generation Y minds and also those who are still lacking the personal development needed to be successful in life.
I guess my question is this…
Did radio and TV completely erode the minds of Gen X and the Baby Boomers? Did we see a lack of control when Generation X spent a ton of time watching TV throughout the day?
The Internet has developed a communication platform that enhances the way we learn and communicate.
Generation Y may lack in terms of true research and grammar but we will never lack in connecting the the global environment.
Gone are the days when you could not communicate with the opposite hemisphere. We are living in a global information highway where knowledge is plentiful…
We may just be losing the essentials of old school thought.
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17 Comments
Jared O'Toole
I think we are just losing the essentials of old school thought. With every generation here are the leaders and there are people who always lack the skills. However I think we are more rounded for being exposed to so much through the web. Maybe to rounded and spread out in some cases.Reply
"there are people who always lack the skills"
Schmoozing, I guess, is a requisite to survive in the social media realm? I'm an introvert who values face-to-face, deep connection with a few rather than a generalized template mass-forwarded to many. Unfortunately, I haven't been able to find the former, because too many people nowadays only want the latter. It's practically impossible to make friends with other introverts — especially painfully shy, solitary ones such as myself — because we simply aren't out there "networking" and really don't care to bother.
Then there's the issue of math (yuck), which I can't do at all. I was a remedial student who never got the hang of even fraction-decimal-percent conversion, yet excelled in terms of written communication. Programming is a kind of math, and these days you have to know at least basic HTML to be *really* involved in the social sphere. Ironic, when considering the programming geeks were always shunned as antisocial, and yet the programmers and the schmoozers seem to have forged a partnership against anyone who doesn't match with either of these skills. In other words, I'm too shy to be a marketer yet too much of an artist to be a programmer. As I read this I'm seeing a blurb on the "Latest Tweets" scroll that says "science and math is trumping art, through influence." How sad that everyone will someday either be a sociopathic cyborg programmer or a plastic supermodel marketing expert. Either way there's no room for soul and heart in social media. It's quantity over quality and that's something I just don't want to participate in. Shy and introverted as I am, I care more about people than I do about algorithms or self-presentation. I guess that makes me a 21st-century, female equivalent of Willy Loman, and we all know what happened to him.
(I hope we all know what happened to poor Willy or even who he was.)Reply
Your post was beautiful. As an introvert myself but one with lots of millenial friends because of my hobby (swing dancing), I can say that everything you say is true. I see it happening. Programmers and cool kids have formed an unholy alliance to marginalize the rest of us. Both sides get something they want: programmers get acceptance and cool kids get a platform to show how popular they are. Liberal fascists are also a part of the alliance, because they get to use social media to intimidate opposition and ostracize anyone who dissents from their liberal orthodoxy. It's an Orwellian world we're living in, but it's not the government who's doing it; it's our fellow man.Reply
When the student becomes the teacher: Take advantage of Gen Y's power « internSHARE Blog
[…] look better – on paper at least. I don't care how many degrees or certificates you have: common sense trumps all. If you can't use common logic there's no point hiding behind all your fancy […]Reply
Kyle, these kind of posts are why I follow you
Sometimes, Gen Y gets ragged on just because it's easier to rag on anybody at all nowadays. I'm sure if the Internet had existed 50 years ago, there would have been just as much inane fluff flying around the Web about how the Baby Boomers and then Gen X were having their minds rotted by radio, television, movies, etc. God forbid the telephone!
There are studies that show Millenials may not be as good at retention of large amounts of facts, but it's a long stretch between those studies (of which there need to be many, many more) and the assumption that Gen Y somehow can't function in communities whatsoever anymore.
As an aside, I was at a networking event today where a nice gentleman repeatedly expressed fear about joining social networks (and rightfully so, if even just a bit). He continued to stress the value of face-to-face contact, until finally someone my age stepped in and said (basically), "Look, I prefer face-to-face contact, too. My whole generation does. But sometimes you can't have that kind of contact, and email/IM/text/Twitter are a much more appropriate extension of communication." That nailed it, for me anway.
Thanks for writing this stuff, and keep up the good work!Reply
Thanks for the link love to Diva Talks BTR show about boomers and SM. I'm a boomer who has "lived" online since the late '90's; but it's still different than having grown-up with the technology integrated into your baby toys. SM simply offers another way to build relations that spans cultures and distance and once people grasp that concept the technology is just a means to an end and the discomfort begins to fall away. That said, we all have much to learn from each other .. no matter the number of our age.Reply
Chase H.
Just because the baby boomers and other archaic and obsolete generations don't understand technology doesn't mean everyone else has to show up and speak face to face. It could be said that before written text, the best way to trade information was by word of mouth, but that method isn't very accurate and efficient with the advent of writing. Then came libraries and written text, which everyone would agree is a huge advent in information technology and communication. Then came the Internet – the ultimate stomping ground for information globally. Telling people to stay away from technology as a form of communication is just some snake oil, almost superstitious thinking with absolutely no reasonable or logical argument for doing so. It's like the baby boomers are saying "Don't use technology because it's the devil". Pretty dumb.
-Chase – Gen X 1976
Chase H: "archaic and obsolete generations don't understand technology…"
Keep in mind, Chase, that 'the internet' was originally conceived, developed, and physically built by members of the Baby Boom generation. Though it's use at that time was restricted to governments, universities, and hackers, the internet has been around since the early sixties.Reply
Worth noting that the boomers' distrust of technology may in fact have something to do with the panic of the Vietnam era, and the fear of Big Brother Nixon's covert surveillance campaigns along with the greater fear of the industrially advanced (and mechanically sociopathic) Soviet Union launching the bomb and destroying humanity. With Vietnam over, the Cold War in its decline, and the eventual close of the Reagan era, Gen X (the '80s generation) got comfy and gave in to MTV, NIntendo, and the early '90s slacker fad. Their own grandparents of the WWII generation had plenty to fear from Hitler's advanced industrialism that literally cannibalized six million Jews and countless other "undesirables" — and understandably bristled at the fact that much of this stuff today is imported from Japan.
Generation Y, meanwhile, thinks the Internet is the greatest thing since Uncrustables because it's like a 24/7 sandbox they can all play in and do whatever they want with. Except the foundation of the internet — as a project developed by MIT with funding from the good ol' Dept. of Defense — speaks volumes about its underlying potential and possibly current use. But the kids are just too stupid and self-absorbed to realize the true implications of what a government-sponsored network can really be used for, especially with all this proposed surveillance legislation masquerading as a "resolution" against internet piracy. The Final Solution is what it is. Dumb, stupid kids just think they're downloading Lady Gaga for free, because they don't know their history and don't care to learn the truth.
But the truth is out there, and knowledge is power — it's just not "cool" to go against the grain.Reply
X man
"Generation Y may lack in terms of true research and grammar but we will never lack in connecting the the global environment."
How does connecting the global environment substitute for the ability to perform true research?
What exactly do you mean by connecting the global environment? Chatting on a fiber optic cable with someone in another country in and of itself does not advance civilization.
"Did radio and TV completely erode the minds of Gen X and the Baby Boomers? Did we see a lack of control when Generation X spent a ton of time watching TV throughout the day?"
Yes. TV is a life consuming waste of time. So are video games. I would estimate 95% of internet content is either wrong, incomplete, and/or useless. I say this as a Gen Xer who wasted too much of his youth with pointless things.
On the up side, your grammar seems ok.Reply
yes, and it started with the boomers, im only 22 so im a millinnial and were gonna have the ungodly task of fixing this country 1 day because the boomers have screwed us over so bad, no jobs, no social security, wars, and you need college for every damn thing, thanks alot…the only good thing to come out of the 60s was music and certain drugs, not overall intelligenceReply
Ming on Mongo
Let's face it, Boomers have had their share of "stupidity" too, and the so-called 'counter-culture' they're associated with, was really just a minority of the whole Boomer generation. It's just that the "extremes" seem so much greater and more obvious now, between the current Gen Y "best & brightest" leaders and their own "less stellar" counterparts.Reply
Jared, bang on! "you need college for every damn thing" No truer words were ever spoken…It's gonna get to the point where you'll need a 6-year apprenticeship and have 9 pieces of ID and a letter from the college to take a shit in the employee bathroom at McDonalds…Someone will have to come in and sign you off on proper position on the seat, leaning forward properly…
Then there's the Catch 22 of needing experience to get experience…For those of you who don't understand, that's the employers who post a job, say 3 to 5 years on-the-job experience needed….How will you get the on-the-job experience if you can't get hired in the field? A college education will only get you so far…College won't give you the skilled hands God gave, college won't give you the work ethic and the drive you wake up with every morning…Experience should never be needed to gain experience, if you stick to that, you will hire no one.Reply
If gen Y still keeps going on their roll of needing remedial english and math before they are allowed to take college courses then all that technology stuff they know about facebook won't help them much….sorry but previous generations used to enter college with a real diploma from high school.Reply
Generation Y (Z?), born in 1996 — sandwiched between the "births" of Yahoo! ('94) and Google ('98). And in contrast to most of my peers, quite a bit of an old-school Luddite myself. I actually quit high school because I was horribly harassed and bullied by the so-called popular crowd, and in my passive observation of social media (without actually having an account), I've seen nothing but the same high-school mentality — from Gen-X'ers and Boomers along with them (social media, "for those who think young," to quote the philosophical genius that is Britney Spears).
I have dyscalculia, which is like dyslexia only with math, so I struggled with math in school but excelled in English. However, having come of age during the rigid NCLB rote-memorization era of education — and the misguided belief that high school should be a boot camp for potential MBA candidates or MIT grads, I struggled even more with the required courses in "technical literacy" that included social media. The ones who excelled at this tripe were, no surprise, the ones who already had internet accounts coming out of their ears and other (already-used) orifices (and we're not talking a serial port). The shy nerds did well with programming, but the wordsmiths, like me (and… me?) either dropped the course or took an F. The only thing I felt comfortable with, the arts and theatre, were cut in favor of technology upgrades and even faculty training seminars on use of social media in the classroom. (Not to mention sports. No money would ever be docked from football. Especially where I'm from, where one of its most infamous residents — a former governor turned two-term President — made headlines nation- and worldwide for his own very public lapses in verbal cognition. Any guesses as to where? Bueller? Bueller?)
Needless to say, I dropped out, knowing I'd never meet the over-the-top requirements that none of our parents or grandparents had to bother with — you studied, did your homework, and went home; "socializing" was for the frat brats, and "taking one for the team" was relegated to sports (or the military). The introverted study-duddies were always thought of as odd, that is until *computer* nerds became more accepted and books, themselves, and those who preferred "old school thought" in print to the flash-bang medium of the Web became, well, weird.
I still cannot (and refuse to) fathom the supposed necessity of 140-character blurbs and cheerleader-level self-aggrandizing in an effort to gain attention from some mop-top pop star. Sorry, Dave, but I tend to disagree on the point about Gen-X'ers and Boomers; our parents did become idiots because of television and video games; just like Twitter and texting being vilified as an "overly compressed" form of linguistic communication, so too, was television lambasted as being the sandwich-pack version of a feature-length movie, and movies themselves believed anathema to the comprehensive Canterbury-esque journey of reading books. While the merits of visual/multi-sensory media as storytelling or message-delivery format are debatable at best, I believe that a line does need to be drawn somewhere, and that social media — and the mentality of those who use it — are indeed just plain stupid. So too is this generation of which I am ashamed to be a member chronologically — perhaps called generation Y because "why" would have required too much thinking power to type. But unlike high school, where the foolishness is at least somewhat self-contained, social media opens up new opportunities for the in-crowd (including the elitist geeks) to unleash their insufferable stupidity unto the whole world. And make it popular, too.Reply
I would like to know what you define as "best and brightest." Because if it's in terms of financial success and/or "social capital," the "best and brightest" of Gen Y so far are mostly internet startup founders like Mark Suckerface and whatsisname that founded Tumblr. They only seem to be successful in their own native field, social media. Not too many restaurateurs, political activists, authors, journalists, artists or nonprofit founders of high school or college age, at least none that I've seen. Maybe for the ones in their thirties, but the only realm the rest seem to be doing well at is technology, which (not surprisingly) attracts others of their same age and text-happy ilk. Their "less stellar" counterparts might well be of lower intelligence or ability, but it's likely that many of them just aren't involved in the fields of I.T. or marketing, and so not able to compete (much less lead) in the digital-obsessed 21st-century workforce. But not everyone, period, is involved in the fields of I.T. or marketing, especially social media marketing, which does require at least a minimal knowledge of certain I.T. concepts (like search engine algorithms, HTML/CSS, and whatever else is involved in maintaining a website). Social media, for me, has its sheep (the users) and its shepherds, each of whom copies a similar style of herding off the other. It's a meta-herd of sorts, a herd of herders gathering their flock to do nothing but pull wool over everyone's Google-y eyes, including each other's and their own. Talk about the four-eyed leading the blind.
Is "best and brightest" supposed to mean innovative? Because all Marky Marx did was steal the database of Harvard's student yearbook, just like all Bill Gates ever did was copy off Steve Jobs (and Jobs himself pull a Xerox on… Xerox). Twitter is just IRC for dumbf*ck celebrities and superficial, get-rich-quick marketing "gurus" and self-help bloggers. Pinterest is no different from sticking real-life yellow Post-it notes on your monitor, macaroni art projects on mom's fridge, or photos on a corkboard with actual thumbtacks. Blogs, meanwhile, are no different from the "old school thought" of op-ed columns or letters to the editor. It's just the fact that it is in fact open to *everyone* and that it's primarily immature Gen-Y folks *leading* rather than learning that's made it so much worse.
Used to be, someone Zuckypants' age would still be doing an apprenticeship rather than running his own company, unless that independent franchise was a lemonade stand or the boss died or he proved legally that he was 27 in leap years. Now he's practically CEO of the world, even though he's nothing more than a screwed-up a**-burger who has no sense of professional decorum, and doesn't have to, because he's the boss, and if you're not on Facebook, you're square (Google "circles" notwithstanding). He's a spoiled brat who wears hoodies to meetings and has given a new meaning to "board room"; I believe there's a skateboard ramp — a skateboard ramp! — leading up to the central office at FB HQ. Social media's popularity with young people is the "decline of old school thought" — for the first time, kids are becoming the boss and making their parents and grandparents'(or at least their parents' and grandparents' respective generations) adapt to their whims or perish. In that regard it's also a harbinger of the decline of Western civilization. (Read Lord of the Flies if you want to know why children should not be in a position of authority.)
Social media? No thanks; I'd rather learn viable, worthwhile skills and put in my time than visit YouTube for skateboarding tutorials with supposed six-figure potential. Methinks one or two Gen-X'ers must have felt nostalgic and sold their respective souls to gen-Y just to make Rick Astley popular again. If I was alive in 1987 I wouldn't have liked "Never Gonna Give You Up" then, and I hate that song even more today.Reply

subset: commoncrawl


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And now, for today's episode of THINGS MOMS NEED TO WORRY ABOUT: Receipts are dangerous. Have you heard this one yet? Paper receipts from stores have bisphenol A (BPA) in them. I know that sounds insane because they're paper. I mean, how does BPA get onto paper? And why is it there at all? And what kind of crazy, upside-down world do we live in when there are dangerous chemicals on our freaking receipts?!?
I just ... sometimes this world.
Anyway, obviously the big takeaway from this news is that we shouldn't let our toddlers play with receipts -- or god forbid, put those things in their mouths. But also: Can we please stop putting BPA on receipts?
That's actually happening, little by little. Suffolk County, in New York, just banned BPAs in receipt paper. And now that Suffolk has made this move, hopefully this will inspire parents and leaders around the country to pass similar laws in their community. If we can make BPAs disappear from bottles, maybe we can make it disappear from paper, too!
Meanwhile, pediatricians recommend parents keep paper receipts away from their children. But that's not all. They also recommend avoiding paper receipts and using electronic receipts as often as possible. (This has become really popular lately, have you noticed?) You should wash your hands after handling receipts. And I hadn't even thought of this myself, but we shouldn't be tossing paper receipts into the recycling because they can contaminate that paper, too.
Environmental Working Group has more information on BPAs in store receipts. And this is kind of cool: You can spot BPA-free paper receipts, at least the ones made by Appleton Papers. The company (who supplies about half of the BPA-free receipt paper out there) weaves red fibers into this paper, which you can see on the back of your receipts.
Did you know that store receipts may be coated with BPA?
Image via comedy_nose/Flickr


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hi im new to this site. i have had asthma since i was a child but after the birth of my second child 4yrs ago it has got much worse. about a month ago i developed chest infection i had 2 lots of antibiotics and 3 lots of steriods. when i saw my cons last week i expained that i was struggling doing everyday tasks, he said it was good that i had managed to stay out of hosp and that i was still getting over the infection then i shouldbe ok. well im not my chest feels tight nearly all the time and im struggling. ive got 3 kids my baby is 8months old and its hardto do everything. i used to be on fexofenadene, omeprazole(as i often had steriods) nasonex and singulair. as soon as i had my baby i went back on the singulair but not the others. im not seeing my cons till may, but ive been at the drs every week each time getting steroids. im using my salbutamol nebs 5mg 4 times a day just to be able to do bits, we are struggling financally so my husband is working long hours, im scared of going into hosp, not for myself but for my husband, as he would not be able to work to look after the kids.
sorry for the moan im just not sure what to do


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Following her barefoot appearance through LAX, Elle Fanning attended the screening of '20th Century Women' at the Christopher B. Smith Rafael Film Center during the 39th Mill Valley Film Festival yesterday(October 13th).
The young starlet wore a custom PRADA pink embellished chiffon knee length pleated dress with an contrasting satin tie shoulder detail and a pink satin bow belt.
I don't necessarily think the color is doing her any favors and I am can't that I am loving the dress design either especially with those satin Mary Jane pumps. A simple pulled back up-do and pink lips finished up her look. Are you sold on Elle's Prada design?
Credit: Pr Photos


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The God of Small Things
I'm god of small things how does the river represent the past future and present of india
Please provide page numbers if Possible
Please provide page numbers if Possible
I went to India a few years ago and I couldn't help thinking about this novel and another one called "A Fine Balance" by Rohinton Mistry. Back to your question. The river in the novel has a history of its own. Generations of men, children, women, grandparents, cows and everything else swim, defecate, pray and cremate in it. To the western eye, it is rather unappealing. To the people around the river, it is their past, present and future. Early in the novel we are let in on memories of a family grieving around a drowned child's coffin. The river is the giver of life and the taker of life as well. The River is shrouded in religious symbolism. It is not only a connection with past generations but with the Gods themselves. It is unfit for swimming and has a nasty smell, but the people who own the nearby hotel tout the area as "God's Own Country." Although the people at the hotel like to point out that the area is steeped in tradition, much of the place has been converted to suit tourists. I suppose that this hints at the river's place in the future.


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Byron Bay Triathlon competitor expected to recover
UPDATE, Monday:
POLICE will not be investigating an incident at the Byron Bay Triathlon on Saturday, where a 31-year-old man collapsed and required CPR.
It's been confirmed the competitor suffered a medical episode.
He was treated at the scene before being conveyed to Byron Bay Hospital for treatment.
Tweed Byron LAC police conducted interviews in case the matter required referral to the Coroner.
"There is no further police investigation in this matter," a spokesman said on Sunday.
INITIAL REPORT, Saturday:
IN dramatic scenes at the Byron Bay Triathlon today, paramedics and Surf Life Savers were forced to perform CPR on a collapsed competitor.
Around 3.30pm, as most race events were coming to an end, a competitor collapsed on the ground in parkland between the finish line and Byron Bay Surf Club.
Onlookers rushed to assist the man, commencing CPR, before paramedics and Surf Life Savers took over.
An Ambulance arrived a short time after, taking the man to Byron Bay Hospital.
It's not known what condition he is in.
Event organisers, QSM, expect to make a statement tomorrow.
Distances in the event included: Olympic (1.5km Swim: 40km Ride: 10km Run), Sprint (750m Swim: 20km Ride: 5km Run) and Tempta for beginners (300m Swim: 10km Ride: 2.5km Run).


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This is my 100th post it took a while but I finally got here!!!
I have not posted for a while because I was waiting to finish up with several things I was working on. They are all finished and I am now posting about all the new things going on around here.
Well the first thing is I am having a giveaway here for one of my new cupcake signs you have a choice of a vintage or a painted glittered sign and your choice of color.
Here are the photo choices below:
All you have to do is post a comment and let me know what style you like best the vintage or the painted if you like it with or without glitter.
That's it and you are entered in my giveaway drawing. If you post my giveway on your blog, newsletter etc. you get entered for each post you make about my giveaway!!!
Just email me about your blog post, etc. and I will enter you for each post you make.
I will pick the winner on Monday Aug. 3rd Good Luck!!!
On to the next bit of news I just finished up with my new website, I changed to a new webhost and I just love it. There are so much more features on my new website. I think you will enjoy your visit here!!! Go over and take a look My Country Cottage
While you are there I am having a Grand re-opening sale of 10% off everything on my site. Just use coupon code 1818b5 at checkout to get the discount.
Now for the last bit of news but not the least I just opened two new Etsy Shoppes: You can go over and visit them here:
Patticake Aprons and My Country Cottage Signs
Well I guess that's if for now, good luck commenting!!!!
Saturday, July 25, 2009
My 100th Post Giveaway!!!
This is my 100th post it took a while but I finally got here!!!
Posted by Rosalie at 4:42 PM 18 comments link to post
Labels: Announcements


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Expenditure approach is the most popular approach to calculate the GDP of a country. It calculates the total spending by the individuals (citizens) and Government to reach out the GDP figure. As per the expenditure method the GDP is calculated as
GDP = Consumption (C) + Investment (I) + Government Spending (G) +
Net Exports (X-M)
The consumption and investment both denote the total spending by all the people living inside the country. The Net export denotes the difference between the export and import of all the goods and services.
Consumption (C) is specified by the overall private and public household expenditure of a country and it is the largest GDP component. It includes all the consumption of durable goods, non-durable goods, foods, petrol/diesel, gas etc. and any medical, house hold, transport services by the whole citizens of the country.
Investment (I) is specified by all the business and personal investments in new assets or any new product buy. For a business firm buying land, equipment, plant can be termed as an investment. For a household, buying a car, new house or some house hold electronics or electrical utilities/furniture can be termed as an investment.
Cash deposits or buying bonds, mutual funds and stocks cannot be termed as investment to avoid double counting for GDP as this money will be used by the business firms to buy lands and machines (already comes under Investment) or by the Government to spend more (comes under Government spending).
Government Spending (G) is specified by total sum of government expenses on final goods and services. It includes the salaries of government employees, spending in defense and infrastructure sectors, providing subsidy to oil, agricultural, fertilizer and education sector. At the time of growth slowdown, Government spends more to lift the GDP and boost the economic activity.
Exports (X) is denoted by the overall export of all the goods and services produced inside the country. It denotes all the goods and services a country produces for other foreign countries and exports the same. Suppose a country produces a car and exports the same to a foreign country, that car has to be included in the calculation of GDP.
Imports (M) is denoted by the overall goods and services that a country imports to use from other foreign countries. As these are produced in the foreign countries and included in their GDP calculation, it has to be deducted while calculating GDP for the importing country.
Also the imported products produced by other countries are included in Consumption and Investment category and must be deducted from the overall GDP to avoid miscalculation.


text: On Thu, 27 Feb 2003 14:12:28 GMT firstname.lastname@example.com wrote: > Full_Name: Matt Heitker > Version: 2.1.13 > OS: Win 2K/Cygwin > URL: ftp://ftp.openldap.org/incoming/ > Submission from: (NULL) (22.214.171.124) > When I downloaded 2.1.13 and tried to build it, it had problems with > liblutil/getpeereid.c and libldap/os-local.c. > Both were looking for a definition of "struct iovec", which was not > found. For reference, MacOS X exhibits this same problem in both 2.1.13 and 2.1.14. #including <sys/uio.h> does indeed show it what an iovec is, and seems to be appropriate for code using readv/writev. Unfortunately, that is not sufficient to get it to build: getpeereid.c: In function `getpeereid': getpeereid.c:61: structure has no member named `msg_accrights' getpeereid.c:62: structure has no member named `msg_accrightslen' getpeereid.c:63: structure has no member named `msg_accrightslen' grepping, I find those are indeed not present in struct msghdr, but rather in struct omsghdr. Curious, I looked at my linux box and found the following in /usr/include/linux/socket.h: /* * As we do 4.4BSD message passing we use a 4.4BSD message passing * system, not 4.3. Thus msg_accrights(len) are now missing. They * belong in an obscure libc emulation or the bin. */ Hm. So linux doesn't have msg_accrights* either. MacOS X happens to include enough of BSD5ish things to have getpeereid() documented in the manpages. Unfortunately they did not include it in libc, even though it is documented. Sigh. AC_REPLACE_FUNCS correctly decides to replace it. About this point I realized that all of this fuss is used only for unix domain sockets, which I'm not using. adding --disable-local to ./configure seems to have fixed things. configure.in only checks for a valid <sys/un.h> before enabling local. The problem is, local gets enabled on my linux hosts and they build it just fine. getpeereid.c:21 tests for SO_PEERCRED, which is defined on the linux hosts but not the mac. As a result, DO_SENDMSG gets #define'd and it tries to use msg_accrights* stuff that doesn't exist anymore. I'm not sure what to do with that, other than --disable-local and go about my merry business for now... ^_^ $ uname -a Darwin Peregrine 6.3 Darwin Kernel Version 6.3: Sat Dec 14 03:11:25 PST 2002; root:xnu/xnu-344.23.obj~4/RELEASE_PPC Power Macintosh powerpc $ gcc -v Reading specs from /usr/libexec/gcc/darwin/ppc/3.1/specs Thread model: posix Apple Computer, Inc. GCC version 1151, based on gcc version 3.1 20020420 (prerelease) Matthew Backes firstname.lastname@example.com


text: I'm new to programming (apart from CSS and HTML) and using the tutorials on the internet, I am thinking of developing my skills by: 1. Learn AppleScript 2. Learn Cocoa I tried a Cocoa tutorial on Apple Developer Connection but it failed (don't know why) but the AppleScript one worked and I guess it would be good to have knowledge of both languages. If you were totally new to programming, where is a good place to start? REALbasic looked good but I can't afford £280 for a license for it so I'm going to stick to free tools. Thanks Seb


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Jun 10, 2012
Cherry & Yogurt Clafoutis
2 eggs, divided
1 ts lemon juice
3 tb sugar, including 1 tb vanilla sugar
250 g plain yogurt
150 g flour
1 pinch of salt
1 pinch of baking soda
about 2-3 tb milk
750 g cherries, pitted
Beat the egg whites with salt until soft peaks are formed. Combine egg yolks, yoghurt, sugar and lemon juice. Whisk until smooth. Mix flour and baking soda and whisk into egg mixture. Add some milk if the batter is too thick. Carefully fold in the beaten egg whites. Pour the batter into a greased casserole pan (24 cm diameter) and add the cherries. Bake in preheated oven at 185 deg C for about 35-40 minutes until golden brown. Let the clafoutis rest for some minutes before sprinkling with powdered sugar and serve.
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Why Connecticut's Drug Overdose Crisis Isn't Slowing Down
This post is also available in: Portuguese (Brazil), Spanish
By Andrew Ba Tran | Trendct.org
On average, two people die of a drug overdose every day in Connecticut.
More people die here from overdoses than in car accidents or by gunshot.
There were about 2,000 drug overdose deaths in Connecticut between 2012 and 2015. The 723 deaths last year were more than twice the number three years ago.
Most often, Connecticut's overdose deaths took place in homes— sometimes those of the victim's mother or sister. But the dead have been found in a variety of other places, too: beneath an I-91 overpass, for example, a motel room, or a parking lot behind a pet store.
The problem has vexed the state and nation for many years. Now, however, researchers and health officials call the problem "an epidemic."
Lawmakers have passed bills in response to the crisis, among them measures to create a prescription database, to provide more training for health and public safety officials, and to provide better access to anti-overdose drugs.
And yet the number of drug-related deaths continues to climb.
Opioid drugs are crucial for the treatment of pain and illness, but have the potential to lead to dependence, abuse, addiction, and then overdose.
Who suffers most? Which communities? Why isn't the epidemic slowing and what can be done about it?
Trend CT seeks to address these questions with data in a series of stories. Tribuna will be sharing the series with its readers in its upcoming issues.
From 2000 to 2014, nearly half a million persons in the United States died from drug overdoses, according to the Centers for Disease Control and Prevention.
During that period, the age-adjusted drug overdose death rate has more than doubled from 6.2 per 100,000 persons in 2000 to 14.7 per 100,000 in 2014.
Connecticut has surpassed the national death rate for drug and opioid overdoses since 2013.
In 2014, the five states with the highest rates of drug overdose deaths were West Virginia (35.5 deaths per 100,000), New Mexico (27.3), New Hampshire (26.2), Kentucky (24.7) and Ohio (24.6).
In New England, New Hampshire, Maine, and Massachusetts had the most statistically significant increases in the rate of drug overdose rates between 2013 and 2014.
New Hampshire had the second-largest increase in the country.
Drug-induced death was the leading cause for injury death among adults in Connecticut. Since 1999, drug-related deaths were similar in number to motor vehicle accidents. There was a spike in 2006 and 2007 but the number fell to a low of 357 deaths in 2010. It has soared, however, in the last five years. Similarly, accidental deaths related to alcohol also saw a sharp increase in 2013 after declining since 2009. According to the data, many of those who died from drug overdoses also had alcohol in their system.
More than 100 million people across the country suffering from chronic pain are undertreated by the medical community, according to estimates from the Institute of Medicine. Untreated chronic pain results in hundreds of billions in medical bills and lost productivity.
According to Dr. Daniel Tobin, assistant professor of medicine at Yale University, the opioid overdose phenomenon traces back to 2001, when the Joint Commission on Accreditation of Healthcare Organizations began requiring hospitals and health care facilities to ask about pain as the fifth vital sign, along with pulse, blood pressure, oxygen saturation, and temperature.
"Pain is a symptom but not an objective vital sign," said Tobin.
The level of pain treatment became part of a quality metric for evaluating hospitals, and, as a result, the rate of prescribing painkilling medicine– largely opioids— rose.
"I think even though it's a decade later, we're seeing the effects of over-prescribing that started in the early 2000s," Tobin said.
Of the 723 overdose deaths in 2015, more than 60 percent involved opioids.
Opioids are synthetic drugs manufactured to work similarly to opiates. They include drugs like oxycodone, methadone, hydrocodone, hydromorphine, and fentanyl.
"It works for some but not everyone. There's no safe and sustainable way to relieve pain completely," said Tobin. Total pain relief is possible on a temporary basis only. "Tolerance develops, so dosage goes up, and risk goes up."
Once the potential for overdose was recognized as a public health problem, slowly more brakes in the form of legislation or new medical standards were applied to the system to monitor and track use of painkillers and discourage doctors from over-subscribing.
Almost 80 percent of the prescribers for opioid medicines are primary care doctors and not pain specialists, said Tobin.
According to a 2011 study, of 133 medical schools, only five had offered any course of training on how to treat pain. Another 17 offered it as an elective.
"There's also this fantasy that patients can be referred to pain specialists," said Tobin "But there's maybe four specialists for every 100,000 in pain."
Data shows that people who use opioids non-medically don't typically get them from doctors or prescriptions, but rather from a relative's medicine cabinet or a friend. One typical scenario: After a root canal, a patient's dental prescription for Vicodin or Percocet could be for 30 days. But the recovery is likely to take is only a few days, so the leftovers get put away.
Doctors cannot assume they can predict who might be predisposed to opioid abuse.
The data shows that opioid overdose deaths affect all demographics.
"It's awful to be in chronic pain. We should be careful we don't overreact and make it difficult for people who are suffering to access it," said Tobin. "We should be assuming some risk for everyone and standardizing this approach."
A public act in 2013 required prescribers in Connecticut to register with the prescription monitoring program— one that started in 2008. However in 2014, half of the prescribers in Connecticut still had not registered, said officials. Those who did found the system time-consuming and difficult to use.
The prescription monitoring program also does not include data from neighboring states. Many patients, especially those who live in towns that border New York, can go back and forth between doctors with neither side sharing the knowledge.
Only in the past few years have legislators increased the number of tools for medical emergency workers and expanded the range of those who can prescribe or administer Narcan, the emergency anti-overdose drug.
For some time, Connecticut's anti-overdose policies lagged behind those of other states. "I think we're finally catching up with where we should be," said Tobin.
Tightening control on prescription pain killers, however, drives some people abusing pills to switch to heroin, which is cheaper and far more available.
According to the data, heroin use is rising again even as abuse of opioids is leveling off.
From 2014 to 2015, the number of times fentanyl was found in the bloodstream of overdose victims increased 150 percent, and last year it was responsible for one quarter of all drug overdoses.
Law enforcement officials have recently reported an increased availability of illicitly manufactured fentanyl. Drug dealers cut heroin with fentanyl to increase the potency of the product.
The only drug that has declined in use over the years is cocaine alone, though deaths increased slightly between 2014 and 2015.
Drug overdose deaths involving heroin continued to climb sharply, with heroin overdoses more than doubling from 2012 to 2015.
"It's like a balloon you squeeze on [one] side and it just becomes larger on the other end," said Tobin.
In our next issue, we look into "Who is dying in Connecticut's opioid overdose crisis?"
"This material originally appeared at TrendCT.org , a publication of the Connecticut News Project, Inc., an independent, nonpartisan, nonprofit organization — a 501(c)(3) — created in 2009 to reinvigorate coverage of state government, public policy and politics."


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News Editor Garrett Fuller had the chance to sit down for a one on one with Erik Morgensen from Games Workshop to talk about Warhammer Online from the perspective of the licenser of the Warhammer IP.
2006 was a big year for Games Workshop with the launch of Mark of Chaos, the Dawn of War expansions, and of course the development of Warhammer Online. Can you give us some insight into what is on the plate for 2007?
Erik Mogensen:
First of all, I'd like to wish you and all the MMORPG.com fans out there a very happy New Year. 2007 is going to be very exciting for all of us!
Obviously, the big news for MMO fans is that there is now less than a year to wait until Warhammer Online: Age of Reckoning's release date. We all know how fast a year can go by! I'm afraid I'm going to have to resort to the old 'nothing's been announced yet' regarding other projects. Sorry. Our other licensees THQ and Namco Bandai Games have plans in the works, but I'm going to leave it to them to reveal what's cooking when they think the time is right. I'll tell you this much: I'm very busy these days!
Read the whole article here.


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When it comes to wrapping presents, there are two types of people in this world: Those who LOVE to gift wrap, and those who HATE it. I'm in the LOVE it category. I rarely use gift bags, and shopping for ribbon and paper is as much fun to me as shopping for shoes and bags. I adore the prepping, the doing and the giving of beautifully wrapped gifts.
When I was in my twenties and pursuing a career as an actress I would take on side jobs to help pay the bills. Well, you can imagine how over the moon I was when I found a part-time job wrapping gifts at Dayton's Department store in downtown Minneapolis.
I remember going in for the interview, the interviewee ask me a few obligatory questions, then walked me to the wrapping counter where all the wrapping supplies were, she handed me a gift box and said "wrap this". I said, "Game on!" I love to wrap and I had been doing it for years, so I felt confident in my abilities. She walked away, came back in a couple of minutes, right when I was finishing up. She picked up the wrapped gift, examined every angle, she looked unimpressed and said "It's ok, we can work with this, if you want the job, you've got it." I started my new job wrapping gifts 2 days later, got a lot better with her help and experience.
I worked 4, 6 or 8 hours shift (depending on my availability and seasonal demands) 2 to 3 days a week for several years, and I had the dry hands and paper cuts to prove it. All these years later I still love to wrap presents. I thought it would be fun to share a video with a few tips and tricks I learned from that job. These tips will make wrapping fun, easy and impressive at the same time.
Tools You'll Need
Sharp scissors, clear gift wrap tape, tape measure, sturdy box, ribbon ( 1.5 inch wide wired ribbon is my favorite), stapler with staples loaded, and gift wrap (I like a thick premium wrap, but any will do), find a clean table top, counter or kitchen island.
Sit back, relax & wrap!
Once your you've got the tools and space you need, put on some holiday music, pour your favorite beverage and get in the holiday spirit.


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Tony Lebron/Startraks
It's no secret that Madonna and Italian designers Domenico Dolce and Stefano Gabbana make for one fabulous fashion dream-team–and Gabbana himself got fans buzzing by taking to Twitter to announce that the Material Girl would reprise her role as the face of Dolce & Gabbana for the label's autumn/winter 2010 campaign. The designer revealed via his account that the iconic singer was filming the new ads in the streets of New York City late last week! "I'm going on the set of the woman campaign…," he Tweeted. "The shooting is going very well!!!!…She's beautiful….Love this!!!…A lot of paparazzi during the shooting!!!" Later, the designer added, "Madonna…she's always the BEST!!!!" We couldn't agree more, and can't wait to see what they have up their stylish sleeves as a follow-up to last season's sexy housewife ads and their sultry film-noir-inspired campaign for the soon-to-debut eyewear line that the trio designed together. Tell us: Are you excited to see Madonna's latest ad campaign with Dolce & Gabbana?


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3/4 pants lycra fabric ties at the sides navy colour
The 3/4 gym pants exeter from Lonsdale has sold out. We did have it in6.
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Cottage Uccle Forest (Brussels Brussels capital)
Environ 1 km de Uccle
4 persons
Cottages of charm Uccle and the vicinity
Popular cities
Select the services
select the capacity
420 /week.
Cottage Uccle Forest (Brussels Brussels capital)
3150 /week.
Cottage Ixelles (Brussels Brussels capital)
Environ 2 km de Uccle
4 persons
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450 /week.
Gite Reves du Monde (Bierges Walloon brabant)
Environ 20 km de Uccle
2 persons
2 children
This apartment in a restored 1930s mansion on the edge of Wavre is 10 minutes walk from Bierge-Walibi Railway Station. It features free Wi-Fi, Indonesian-themed décor and garden with seasonal pool. ... Read more
0 /week.
Cottage De Rode Beuk (Haaltert Flandre orientale)
Environ 26 km de Uccle
6 persons
A warm welcome is guaranteed at De Rode Beuk, our holiday house in Haaltert, a town in the province of East Flanders, Belgium. It is part of a classic mansion but ... Read more


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Dan Brunn's Code Red House Nears Completion
Below are the latest photos from Dan Brunn's blog showing the Code Red house stairwell complete with stainless steel structural standoffs by AMPG that were powder coated white. See more of Dan [...]
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Isaiah 52:13
He? Prosper? High? Lifted up? Greatly Exalted? A priest? Someone who cleanses and hold usaccountable?
Amazing! Startling! Stunning! Astonishing!
This amorphous mass of human flesh has morphed into the Lord of Glory!
Who would believe such a report?
Who would ever know that He was the arm of the Lord?


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Memorial Visitors Center & Store 400 7th Street NW Ground Floor Washington, DC, 20004
Phone: 866-569-4928 or 202-737-3400
See map: Google Maps
E Street, NW bordered by 4th and 5th streets; three blocks from the Visitors Center
The National Law Enforcement Officers Memorial Fund was established in 1984 to generate increased public support for the law enforcement profession by permanently recording and appropriately commemorating the service and sacrifice of law enforcement officers. The fund also provides information to help promote law enforcement safety, maintains the National Law Enforcement Officers Memorial, and is currently building the first-ever National Law Enforcement Museum, located across from the Memorial in Washington, DC's historic Judiciary Square.
Dedicated in 1991 by President George H.W. Bush, the National Law Enforcement Officers Memorial comprises a three acre park honoring all of America's federal, state, and local law enforcers, in particular those officers who have made the ultimate sacrifice in serving and protecting our communities. Designed by award winning Washington, DC, architect Davis Buckley, the park setting showcases the two pathways of remembrance, which feature blue-gray marble walls engraved with the names of more than 19,000 fallen law enforcement officers. Each spring, the names of the officers killed during the previous year are engraved on the Memorial walls. Approximately 200,000 people visit the Memorial every year.
The Memorial Fund sponsors many programs and exhibitions throughout the year. The largest of these is the Annual Candlelight Vigil, held each May 13th to honor fallen officers and to dedicate the Roll Call of new officer names added to the Memorial walls.
The National Law Enforcement Officers Memorial Fund Visitors Center & Store, located about three blocks from the Memorial, houses various exhibits covering the history of the Memorial and the law enforcement officers it honors. The Visitors Center also features a gift shop where guests can purchase a memento of their visit to the Memorial. Proceeds from gift shop purchases help fund the Memorial and its programs.
Monday - Friday 9am - 5pm
Saturday 10am - 5pm
Sunday Noon - 5pm


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February 27, 1931
BANKERS' TRUST CO.v.PEORIA RY. TERMINAL CO.; BATTLES V. PEORIA & PEKIN UNION RY. CO.
Appeal from the District Court of the United States for the Northern Division of the Southern District of Illinois.
Author: Alschuler
Before ALSCHULER, EVANS, and SPARKS, Circuit Judges.
ALSCHULER, Circuit Judge.
In the receivership of the Peoria Railway Terminal Company, appellee intervened, filing its alleged preferred claim of $79,635.94. There was filed a bill to foreclose mortgage upon the railroad securing its defaulted first refunding 4 1/2 per cent. gold bonds, and the receivership was extended to include the foreclosure proceeding, with which it was consolidated. Decree of foreclosure was entered, whereunder the railroad property was sold, the Chicago, Rock Island & Pacific Railway Company being the purchaser, and, upon approval of the sale, the property was turned over to the purchaser. Later appellee's claim was allowed and given priority in the distribution of the proceeds of the foreclosure sale. From the order of allowance of the claim with priority, the receiver alone prosecuted the appeal.
Appellee moves to dismiss the appeal because the necessary parties are not before this court, and because all parties interested in and affected by the order, particularly the purchaser at the foreclosure sale, have not joined as appellants, and were not otherwise brought into the appellate proceeding.
In support of the motion a number of cases are cited for appellant which have more or less tendency to sustain his contention.*fn1 But we are bound to follow the decision of the Supreme Court in Bosworth v. Terminal R. Ass'n, 174 U.S. 182, 19 S. Ct. 625, 43 L. Ed. 941, in which the precise question here involved was decided. There, as here, an intervening creditor, claiming a lien upon railroad property superior to a mortgage, secured a decree sustaining his claim as a prior lien, after the property had been sold under foreclosure proceedings, the sale approved by the court, payment of the sale price, and delivery of the property by the receiver to the purchaser. The receiver alone appealed from the decree awarding priority of the claim, and there, as here, it was contended that the party really and beneficially interested in opposing the claim was the purchaser at the sale, and that the court was without jurisdiction to entertain the appeal unless the purchaser was a party thereto.
The right of the receiver alone to prosecute the appeal, notwithstanding others might have the same right, was sustained, and no subsequent modification of this holding appears.
The motion to dismiss the appeal ...
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In a sudden turn of events, the University of Oregon student government has increased funding to a conservative student magazine that had been the target of alleged viewpoint discrimination.
The Oregon Commentator came under fire after satirizing transgendered student senator Toby
Hill-Meyer, who had requested that the campus newspaper refer to him using the general-neutral pronouns "ze" for "he," and "hir" for "him." Consequently, the Associated Students of the University of Oregon
(ASUO) recognized and denied funding to the magazine for poking fun at Hill-Meyer. That is when the Commentator contacted the Foundation for Individual Rights in Education (FIRE).
FIRE's director of legal and public advocacy, Greg Lukianoff, was taken back by the student leaders' reaction.
"The Commentator, somewhat unsurprisingly, made fun of [Hill-Meyer]," says Lukianoff. "[But] for that to lead to a situation where the student government refuses to recognize their mission, refuses to fund them for several months, and continues to debate whether or not they have to recognize a group at all, is simply remarkable."
Not long after FIRE sent protest letters to the university administration and campus leaders, the student government re-recognized the Commentator — and even increased the magazine's budget by more than five percent. Lukianoff says although that is all welcome news, UO administrators never criticized the student government's initial censorship.
"If you're distributing student fees, you're not allowed to distribute them on the basis of viewpoint, period. That's [directly] from the Supreme Court," the FIRE spokesman says. "And to let the student government languish, actually requesting help from the administration, and not clarify what their constitutional duties are, in our opinion, is unforgivable."
Pauline Austin, a spokeswoman for the university, had no comment on the story when contacted. But FIRE says it is hopeful both the school and its student leaders have learned a lesson, and that student fees will no longer be used as a "tool to favor or disfavor particular viewpoints."Download file "FIRE's Heat Douses Student Censorship in Oregon"
Schools: University of Oregon Cases: University of Oregon: Derecognition of Student Group for 'Offensive' Publication


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In a report commissioned by Prime Minister David Cameron set to be released today, Portas will make 28 recommendations to save British high streets from the crisis point reached after years of neglect.
Her recommendations will include the creation of an annual national market day to promote local marketplaces, easing restrictions on overnight deliveries to town-centre shops, and relaxing licensing rules to encourage entrepreneurs to establish market stalls. She will also call on local governments to cut through the red tape surrounding parking restrictions to lure shoppers back to town centres.
I believe that our high streets can be lively, dynamic, exciting and social places that give a sense of belonging and trust to a community. A sense of belonging which, as the recent riots demonstrated, has been eroded and in some instances eradicated, Portas told the Telegraph.
The "Queen of Shops" said the economic downturn, growth of out-of-town superstores and rise of online shopping have coalesced to create an impossible situation for many town-centre traders. Vacancy rates have soared over the last two years, leaving one in seven shops on UK high streets empty.
Reviving town centres will require creative thinking, Portas said.
What Im proposing is that we look at our high street in a different way, she told the BBC, and we look at it as a multi-functional social and shopping high street, so that we create footfall back on the high street for other uses just than shopping.


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Royals-Rangers preview
ARLINGTON, Texas -- The Texas Rangers and Kansas City Royals are both looking to steady the ship going into a four-game series that opens Thursday night at Globe Life Park.
The American League West-leading Rangers (58-44) have seen what was once a 10-game division lead dwindle to 2 1/2 games thanks to a 7-17 stretch.
The defending World Series champion Royals (49-51) are in fourth place in the AL Central.
The pitching matchup in the opener is a repeat of last Saturday's duel in Kansas City, which the Rangers won 7-4. Texas would love to get a repeat performance out of ace Cole Hamels, who picked up the win after allowing one run (none earned) and five hits in 5 1/3 innings.
The 32-year-old lefty, 11-2 with a 2.87 ERA, is among the league leaders in several major categories, including wins, ERA and strikeouts.
Hamels is facing Yordano Ventura (6-8, 4.99 ERA) again. The right-hander set down the first nine hitters he faced before a walk and a two-run homer by Jurickson Profar started the fourth. Ventura took the loss after being charged with three runs and three hits in five innings with four walks and five strikeouts.
Hamels owns the last three and five of the last six wins by a Texas starting pitcher. That's why the Rangers made the first of what could be several trades to upgrade the pitching staff with Wednesday's deal to land starter Lucas Harrell and reliever Dario Alvarez from Atlanta.
"You look at both pitchers we acquired, they can help our ballclub, fill a role and add depth," Rangers general manager Jon Daniels said. "With Lucas, he is a guy who is throwing the ball well. He has been around a little bit, had some experience and he has been on a little bit of a roll."
Harrell, 31, fills an immediate need in the rotation, with his turn coming up Sunday against the Royals. Harrell has gone 2-2 with a 3.38 ERA in five starts for the Braves this season.
"He has the capability of keeping us in the ballgame," manager Jeff Banister said.
Alvarez is a hard-throwing lefty with 3.00 ERA with 28 strikeouts and five walks in 15 innings. He has held opponents to a .200 batting average.
The Rangers did give up highly-regarded power prospect Travis Demeritte. The 21-year-old infielder was hitting .272 with 25 home runs in 88 games for High-Class A High Desert.
Daniels added the Rangers aren't necessarily done with the trade deadline looming Monday. While the search for arms tops the list, upgrading other facets of the club could be on the table.
"I wouldn't rule anything out," Daniels said, "but pitching is our priority."
Texas took the last two of three last weekend in Kansas City and it 6-4 against the Royals since the start of 2015. The teams split four games in Arlington in 2015, but the Rangers are just 5-7 against Kansas City at Globe Life Park since start of 2012.
Royals manager Ned Yost held a team meeting before Wednesday's 7-5 win over the Los Angeles Angels to try to ease concerns for a club that's fading in the standings and is inundated with trade rumors.
The get-together was quick -- Yost said about two minutes -- and to the point.
"We know what we have ahead of us, we've known the trials that we've been through in the past and we've known that we've had our backs against the wall before," he told MLB.com. "You know that you always come out of it. Just go out, enjoy your teammates and play the game like you did when you were 12 years old. That's what we do so well when we're successful, is we just go out and play hard and have fun doing it. So sometimes you just take a step back and relax a little bit and inch your way out."


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These White Chocolate Fortune Cookies are perfect for a Valentine's gift! They're a great alternative to the traditional chocolate dipped strawberries and they're also super cute and fun! Make a dozen and put them in a gift box for your… Continue Reading →
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A Minna Chief Magistrate's Court has ordered a 14-man syndicate that specialises in issuing forged letters of admission and certificates of the Niger State College of Education to be remanded in prison till May 13.
Danlami Abubakar and 13 others were arraigned on a four-count charge by the Director of Public Prosecution (DPP), Mu'azu Shehu, for joint acts, forgery, being in possession of forged documents and using as genuine a forged document, contrary to sections 79, 364, 368 and 366 of the Penal Code.
Other members of the syndicate include Hussaini Vatsa, Suleiman Ahmad, Umaru Salihu, Ibrahim Yusuf and Moh'd Bello Waziri.
Others are Zakaryah Ibrahim, Garba Gwalu, Ndaman Umar, Moh'd Shabako, Umar Yabagi, Aminu Usman, Usman Musa and Hassan Mohammed.
The prosecutor said the accused between December last year and January in Minna formed a common intention to issue fake admission letters as genuine documents to candidates.
The prosecutor said the accused caused injury to the public by their action.
They were also found to be in possession of fake admission letters.
One of the accused, Usman Jibrin Musa, was alleged to have used as genuine, scanned and reprinted admission letters of the college, which he issued to Zulai Aliyu, Umar Kabir and Zainab Mohammed.
Thirteen members of the syndicate pleaded not guilty to the charges. The plea of Awwal Gana, who is said to be at large, could not be taken.
The accused counsel, Zakariyahu Bello, made an oral application for bail, a prayer that was not opposed by the prosecutor.
Magistrate Bilqquis Gambo Yusuf said the accused were entitled to a bail and directed the defence counsel to make a formal prayer for it.
She ordered them to be remanded in prison and adjourned the case till May 13 for further hearing.


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Oct. 6, 2012 --If you're looking for a cheap, easy breakfast this weekend, Krispy Kreme in Collingswood, New Jersey, has some deals for you.
On Saturday, October 6, 2012, if you buy one dozen original glazed doughnuts, you can get a second dozen for $1.
And on Sunday, October 7, 2012, you'll get a free glazed doughnut with any purchase.
There will also be free kids' activities, such as coloring and temporary tattoos.
The Krispy Kreme is located at 1170 Haddon Avenue, near the intersection with Cuthbert Boulevard.


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