text:
The battle between Good and Evil isn't what it used to be. In the old days, the distinction between the two camps was easy: Nazis vs Allies, Darth Vader vs Obi-Wan Kenobi, South Park kids vs Satan and Saddam. Now, anyone waving holy scriptures is more likely to blow you up or invade your country than sit you down for a nice chat and a cup of tea. And here is Infernal, a game where you play an angel - by which we mean an agent of the military wing of Heaven on Earth, of course - cast out by the forces of light and recruited by Lucifer. And why? Because the good guys have developed the technology to remove humankind's free will and intend to use it when God isn't looking. And we thought Creationists were bad.
But don't be fooled into thinking this is some Kevin Smith-style critique of modern politics and religion. Dogma it is not. Like any action game story, it's really just an excuse to shoot people and blow stuff up, something it makes clear right from the get-go. After some rushed exposition, via cutscenes that at this stage owe more to the Thunderbirds school of animation than Pixar's, you're thrown straight into the mayhem-end of the fray, forced to fight your way out of a trendy bar. The screen becomes a glitterball of light, blood and bullets, as Infernal shows off its impressive visuals and you start maiming cops and the odd civilian to a relentless metal soundtrack.
Though you can sneak around and hide behind pillars as you lay covering fire, Infernal is not about subtlety. The Devil never cared much for refinement, even if he does recruit you wearing a suit and tie. Your first unholy mission has you ploughing your way through an ancient monastery. But it's okay, these monks aren't the peace-loving, vow-taking kind; they fight back with guns and shuriken.
As you progress through the game, you'll be causing havoc in steelwork factories, airports and trains, using machineguns, sniper rifles, flamethrowers, lasers and even taking over gun turrets and getting down to some hand-to-hand combat. The gunplay is actually quite realistic, especially given the fantastical setting, and you'll have to contend with heavy recoil and a lot of wasted, stray bullets. Getting a headshot on a moving target is tricky business, and even reloading is done by the book: change your clip when it's still half full and you'll be throwing away the clip's remaining ammo. On the other hand, you can take a barrelful of bullets without slowing down, so realism clearly takes a backseat when it gets in the way of heart-pumping fun.
As well as health, you need to keep an eye on your mana, which is used to power your demonic abilities: special fiery shots and teleportation. Churches and holy lights decrease your mana, while absorbing the souls of fresh corpses replenishes it. Your first chance to do just that comes early on, when you can execute a little old man sweeping a yard before sucking his life force. When an angel falls, he falls hard. It's no coincidence that Infernal's original name was Diabolique: License to Sin, a title presumably dropped when Metropolis realised it wasn't making a soft porn movie. In fact, both the story and the design have undergone many changes since it was first announced two and half years ago.
While in its final incarnation it's being billed as an action/adventure, the action is really what matters here. Puzzles are of the "find the remote door-opening mechanism" type. And using your infernal vision to see secret security codes and hidden sources of health and mana doesn't quite count as adventuring. Teleportation adds a novel twist though, allowing you to jump to another location for a few seconds. You can try to Nightcrawler your way through a level, appearing behind enemies and then vanishing when the bullet has left your gun - extremely satisfying if you can pull it off, and a visual treat too - but it's most useful for leaping beyond gates and security lasers long enough to disable them.
Though the third-person perspective doesn't let the action be quite as fluid as we'd like it - the over-the-shoulder camera is more suited to slower-paced games like Resident Evil 4 - everything is so stylishly realised that you soon get sucked into the thick of things. There are some problems that we'd like to see rectified before release though. The enemy AI feels a touch unnatural, and while monks and soldiers take cover and attempt to outflank you, their movements are jerky and unrealistic. You never feel there's a dynamic intelligence at work behind them. The difficulty balance is also a tad askew. You can kill everything in your path without breaking a sweat only to suffer a thousand deaths in the end-of-level scenario. These set pieces often involve unending streams of enemies that keep regenerating until you figure out the appropriate course of action. It can be frustrating, although being forced to think up strategies and solutions is also very compelling.
It's a shame the general quality and polish evident in the graphical effects is let down slightly by some unconvincing dialogue and below-par acting. The incidental enemy lines throw up such gems as: "Ow, I've got a damn injury!" and "The enemy attacked us!" And you know something's been lost in the translation from the original Polish when you overhear exchanges like: "Who's guarding the power station?" "The boss." "Oh yeah, no happy ride for our guest then."
There's still a lot to admire here though, whether it's the motes of dust dancing in the cathedral glow that shines through the windows, the sheer intensity of the battles or the gameplay nuances your hellish powers add to the mix. With a bit more work, Infernal should have the muscle and panache to convert a fair few to Satan's cause.


text:
The Role of Phytocannabinoids in Autism Therapy Part 2
In part one of this series the preclinical scientific evidence illustrating the involvement of the endocannabinoid system (ECS) in the physiological progression of Autism Spectrum Disorder (ASD) and comorbid conditions was provided. Here we'll highlight some of the pharmacological characteristics that phytocannabinoids share with endocannabinoids, the use of phytocannabinoids in the treatment of symptoms and diseases associated with ASD, and why having access to a variety of cannabis chemotypes will always be preferable to a select cannabinoid and/or ratio.
The anecdotal reports of successful cannabinoid therapies seem to be supported by the fact that phytocannabinoids from cannabis, and other natural sources, display similar pharmacological characteristics to that of endocannabinoids that are dysregulated in ASD.[31] The potential therapeutic value of supplementing the endocannabinoid system with phytocannabinoids has been suggested in the treatment of a number of diseases with suspected underlying endocannabinoid deficiencies.[34] Documentation of the safety and clinical efficacy of phytocannabinoids in a variety of treatments continues to grow.[16] In regards to the treatment of ASD, some similar characteristics are worth highlighting, including:
- Promotion of Neurogenesis[19, 2, 5]
- Neuroprotection[15, 23, 35]
- Powerful Antioxidants[3, 31, 15]
- Neuromodulation[8, 23, 31, 43]
- Anti-inflammatory[31, 18]
Based on preclinical research ECS deficiencies appear to be associated with ASD, and it's implicated as a potential target for treatment. Phytocannabinoids target the ECS and display similar pharmacological characteristics to endocannabinoids that are dysregulated. It's been suggested that therapies for conditions with corresponding ECS deficiencies may include supplementation with phytocannabinoids. This seems to potentially support the anecdotal reports of successful cannabinoid therapies in ASD.
Treating Symptoms Associated with ASD
There is a considerable body of supportive preclinical data in regards to targeting the ECS with phytocannabinoids in the treatment of a number of symptoms and diseases associated with ASD. For sake of brevity some of these will be highlighted and cited:
- G.I. Disorders[4, 10, 42]
- Repetitive Behaviors[6, 9, 14]
- Seizures[20, 32, 40]
- Sleep Dysfunction[28, 41]
- Self Injurious Behavior and Tantrums[27, 29, 30]
- Tuberous Sclerosis[21, 38, 44]
- Cerebral Ischemia[37, 7, 26, 12]
- Depression/Anxiety[17, 1, 36]
- Cachexia[11, 24]
Again, anecdotal reports of success appear to be supported by an abundance of preclinical research that indicates a potential role for phytocannabinoids in the treatment of symptoms and diseases associated with ASD.
Botanical Extracts > Dronabinol
Due to the relatively common off-label use of Dronabinol (a man-made/synthetic form of THC), for ASD therapy, it seems relevant to point out the substantial data, including clinical studies, suggesting that the combined administration of CBD along with THC (and possibly other cannabinoids/terpenes present in cannabis) exhibit additive and synergistic effects. This is known as the entourage effect and results in greater clinical efficacies when compared to either cannabinoid alone.[25, 18, 34]
The second most prominent cannabinoid in cannabis is cannabidiol (CBD).[13] CBD has been shown to inhibit intoxication, sedation, and tachycardia associated with delta-9-tetrahydrocannabinol (THC).[34] It's been shown to increase the clinical efficacy of THC, while adding therapeutic value in its own right.[34]
A large portion of the research conducted thus far with ASD and cannabinoids has been with Dronabinol (a synthetic form of THC) alone. Dronabinol has indicated potential for treatment in a single adolescent case study of autism.[22] Does that mean THC along with CBD might offer increased clinical efficacy similar to the way they have been demonstrated to with other conditions?[34] Based on the results of previous research and anecdotal reports this might be the case.
The added benefit of additional cannabinoids (and the added benefit of specifically tailoring ratios) is an important component that sets botanical extracts from cannabis apart from THC or CBD alone. This is why having access to a variety of cannabis chemotypes will always have more potential for therapeutic value than a select cannabinoid, ratio, or cannabis chemotype.
Based on their ability to target the ECS, and their shared characteristics with dysfunctional endocannabinoid levels, preclinical evidence supports the potential therapeutic value of phytocannabinoids in ASD therapy.
Highlighting individual pharmacological characteristics of CBD, THC, and other phytocannabinoids is beyond the scope of this paper. However, based on the ECS deficiencies associated with ASD, and the ability of phytocannabinoids to target and modulate aspects of the deficiencies, anecdotal reports seem to be supported by the best available scientific data. It appears that phytocannabinoids have the potential for therapeutic value in some severe cases of ASD.
Citations & References
- Almeida, Valeria, et al. "Cannabidiol exhibits anxiolytic but not antipsychotic property evaluated in the social interaction test." Progress in NeuroPsychopharmacology and Biological Psychiatry 41 (2013): 30-35.
- Avraham, Hava Karsenty, et al. "The cannabinoid CB2 receptor agonist AM1241 enhances neurogenesis in GFAP/Gp120 transgenic mice displaying deficits in neurogenesis." British journal of pharmacology2 (2014): 468-479.
- Borges, Rosivaldo S., et al. "Understanding the molecular aspects of tetrahydrocannabinol and cannabidiol as antioxidants." Molecules10 (2013): 12663-12674.
- Camilleri, Michael, et al. "Cannabinoid receptor 1 gene and irritable bowel syndrome: phenotype and quantitative traits." American Journal of Physiology Gastrointestinal and Liver Physiology 304.5 (2013): G553-G560.
- Campos, Alline Cristina, et al. "Multiple mechanisms involved in the largespectrum therapeutic potential of cannabidiol in psychiatric disorders." Philosophical Transactions of the Royal Society B: Biological Sciences 367.1607 (2012): 3364-3378.
- Casarotto, Plinio C., et al. "Cannabidiol inhibitory effect on marble-burying behaviour: involvement of CB1 receptors." Behavioural pharmacology 21.4 (2010): 353-358.
- Choi, In-Young, et al. "Activation of Cannabinoid CB2 Receptor–Mediated AMPK/CREB Pathway Reduces Cerebral Ischemic Injury." The American journal of pathology 182.3 (2013): 928-939.
- Davis, Mellar, et al. "The emerging role of cannabinoid neuromodulators in symptom management." Supportive care in cancer1 (2007): 63-71.
- Deiana, Serena, et al. "Plasma and brain pharmacokinetic profile of cannabidiol (CBD), cannabidivarine (CBDV), ∆9-tetrahydrocannabivarin (THCV) and cannabigerol (CBG) in rats and mice following oral and intraperitoneal administration and CBD action on obsessive–compulsive behaviour." Psychopharmacology 219.3 (2012): 859-873.
- Di Sabatino, A., et al. "The endogenous cannabinoid system in the gut of patients with inflammatory bowel disease." Mucosal immunology 4.5 (2011): 574-583.
- Engeli, Stefan. "Central and peripheral cannabinoid receptors as therapeutic targets in the control of food intake and body weight." Appetite Control. Springer Berlin Heidelberg, 2012. 357-381.
- Garcia-Bonilla, Lidia, et al. "Immune mechanisms in cerebral ischemic tolerance." Frontiers in neuroscience 8 (2014).
- Gertsch, Jürg, Roger G. Pertwee, and Vincenzo Di Marzo. "Phytocannabinoids beyond the Cannabis plant–do they exist?." British journal of pharmacology 160.3 (2010): 523-529.
- Gomes, Felipe V., et al. "Facilitation of CB1 receptor-mediated neurotransmission decreases marble burying behavior in mice." Progress in NeuroPsychopharmacology and Biological Psychiatry 35.2 (2011): 434-438.
- Hampson, Aidan J., Julius Axelrod, and Maurizio Grimaldi. "Cannabinoids as antioxidants and neuroprotectants." U.S. Patent No. 6,630,507. 7 Oct. 2003.
- Hazekamp, Arno, and Franjo Grotenhermen. "Clinical Studies With Cannabis and Cannabinoids, 2005-2009." (2013).
- Hill, Matthew N., and Boris B. Gorzalka. "The endocannabinoid system and the treatment of mood and anxiety disorders." CNS & Neurological Disorders-Drug Targets (Formerly Current Drug Targets-CNS & Neurological Disorders) 8.6 (2009): 451-458.
- Izzo, Angelo A., et al. "Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb." Trends in pharmacological sciences 30.10 (2009): 515-527.
- Jiang, Wen, et al. "Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic-and antidepressant-like effects." Journal of Clinical Investigation11 (2005): 3104.
- Jones, Nicholas A., et al. "Cannabidiol exerts anti-convulsant effects in animal models of temporal lobe and partial seizures." Seizure 21.5 (2012): 344-352.
- Krueger, Dilja D., and Nils Brose. "Evidence for a common endocannabinoidrelated pathomechanism in autism spectrum disorders." Neuron 78.3 (2013): 408410.
- Kurz, René, and Kurt Blaas. "Use of dronabinol (delta-9-THC) in autism: A prospective single-case-study with an early infantile autistic child." (2010)
- Lara-Celador, I. et al. "Using the Endocannabinoid System as a Neuroprotective Strategy in Perinatal Hypoxic-Ischemic Brain Injury." Neural Regeneration Research8 (2013): 731–744.
- Marco, Eva M., et al. "The role of the endocannabinoid system in eating disorders: pharmacological implications." Behavioural pharmacology 23.5 and 6 (2012): 526-536.
- McPartland, John M., and Ethan B. Russo. "Cannabis and cannabis extracts: greater than the sum of their parts?." Journal of Cannabis Therapeutics 1.3-4 (2001): 103-132.
- Murikinati, Sasidhar, et al. "Activation of cannabinoid 2 receptors protects against cerebral ischemia by inhibiting neutrophil recruitment." The FASEB journal 24.3 (2010): 788-798.
- Müller-Vahl, K. R., et al. "Cannabis in movement disorders." Forschende Komplementärmedizin/Research in Complementary Medicine 6.Suppl. 3 (2004): 23-27.
- Murillo-Rodriguez, Eric, et al. "The emerging role of the endocannabinoid system in the sleep-wake cycle modulation." Central Nervous System Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Central Nervous System Agents) 11.3 (2011): 189-196.
- Onaivi, E. S., et al. "Consequences of cannabinoid and monoaminergic system disruption in a mouse model of autism spectrum disorders." Current neuropharmacology 9.1 (2011): 209.
- Passie, Torsten, et al. "Mitigation of post‐traumatic stress symptoms by Cannabis resin: A review of the clinical and neurobiological evidence." Drug testing and analysis7-8 (2012): 649-659.
- Pertwee, R. G., et al. "International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB1 and CB2." Pharmacological reviews 62.4 (2010): 588-631.
- Porter, Brenda E., and Catherine Jacobson. "Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant epilepsy." Epilepsy & Behavior 29.3 (2013): 574-577.
- Russo, Ethan, and Geoffrey W. Guy. "A tale of two cannabinoids: the therapeutic rationale for combining tetrahydrocannabinol and cannabidiol." Medical hypotheses 66.2 (2006): 234-246.
- Russo, Ethan B. "Taming THC: potential cannabis synergy and phytocannabinoid‐terpenoid entourage effects." British Journal of Pharmacology 163.7 (2011): 1344-1364.
- Sanchez, A. J., and A. Garcia-Merino. "Neuroprotective agents: cannabinoids." Clinical Immunology1 (2012): 57-67.
- Schier, Alexandre Rafael de Mello, et al. "Cannabidiol, a Cannabis sativa constituent, as an anxiolytic drug." Revista Brasileira de Psiquiatria 34 (2012): 104-110.
- Schmidt, W., et al. "Cannabinoid receptor subtypes 1 and 2 mediate long-lasting neuroprotection and improve motor behavior deficits after transient focal cerebral ischemia." Neuroscience 227 (2012): 313-326.
- Shu, Hai-Feng, et al. "Expression of TRPV1 in cortical lesions from patients with tuberous sclerosis complex and focal cortical dysplasia type IIb." Brain and Development 35.3 (2013): 252-260.
- Russo, Ethan B. "Clinical endocannabinoid deficiency (CECD): can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions?." Neuro endocrinology letters 25.1-2 (2003): 31-39.
- van Rijn, Clementina M., et al. "Endocannabinoid system protects against cryptogenic seizures." Pharmacol Rep 63 (2011): 165-168.
- Ware, Mark A., et al. "The effects of nabilone on sleep in fibromyalgia: results of a randomized controlled trial." Anesthesia & Analgesia 110.2 (2010): 604-610.
- Wright, K. L., M. Duncan, and K. A. Sharkey. "Cannabinoid CB2 receptors in the gastrointestinal tract: a regulatory system in states of inflammation." British journal of pharmacology 153.2 (2008): 263-270
- Youssef, F. F., and A. J. Irving. "From cannabis to the endocannabinoid system: refocussing attention on potential clinical benefits." West Indian Medical Journal 61.3 (2012).
- Zurolo, E., et al. "CB1 and CB2 cannabinoid receptor expression during development and in epileptogenic developmental pathologies." Neuroscience 170.1 (2010): 28-41.

subset: commoncrawl


text:
Austerity is grinding Portugal down. The economy is adjusting to past excesses and flourishing firms are not hard to find. But the overall picture, mirrored across southern Europe, is of a people losing confidence in the future.
With domestic demand depressed by deep public spending cuts and a slump in investment, the risk is that improving exports alone will not be enough to restore growth. That would trap the government in a vicious circle, forever needing fresh cuts to meet its deficit and debt targets.
Joao Leite, an economist with Banco Carregosa in Lisbon, said he used to have faith in the belt-tightening cures of the International Monetary Fund, one of Portugal's taskmasters, because of its long history of fighting financial fires.
Now, Leite is disillusioned.
"I thought that some of this austerity was needed. Maybe I innocently believed that this was the right path," he said. "But I honestly must say that I didn't see this coming like it did."
The economy shrank 3.2 percent in 2012 and Portugal's troika of international lenders - the IMF, the European Central Bank and the European Commission - expect a further fall of 2.3 percent this year. As recently as November they were projecting a drop of just 1 percent.
Unemployment last quarter was 16.9 percent, up 2.9 percentage points from a year earlier. Because the jobless rate is a lagging indicator, the government expects it to reach 18.5 percent in 2014. Some economists have pencilled in 20 percent.
The troika has granted Portugal an extra year to hit its bailout targets and Lisbon is hoping the European Union will agree next month to give it more time, up to 15 years, to repay an emergency loan it took out in 2011.
But Leite believes the austerity should be spread out over a decade, not compressed into three or four years.
"It's the right medicine, but we should be taking smaller doses for a longer period of time," he said.
Protests against spending cuts and higher taxes have grown in recent weeks but have remained peaceful. The centre-right coalition faces a no-confidence vote in parliament but it enjoys a solid majority, making the motion symbolic.
Danger Zone
Paula Carvalho, chief economist at BPI bank, agreed that it would be very difficult for Portugal to avoid sinking into a recessionary spiral, with the risk that its fiscal targets will keep slipping, in the absence of an upturn in European demand.
"We are in the danger zone right now," she said.
There are grounds for hope. Bond yields have fallen sharply since last year. This permitted Portugal to successfully sell a five-year bond in January, its first issue since the bailout, and it aims to sell 10-year debt soon.
The issuance is part of a strategy to regain normal capital market access this year, possibly with the crutch of the euro zone's and the ECB's bond-buying programmes, as a prelude to graduating from the bailout programme by mid-2014.
And companies that have watched domestic demand shrivel are carving out new markets overseas. In the past four years, Portugal has turned in the fourth-best export performance in the euro zone after Germany, Ireland and Spain.
In the year since Reuters visited Bluepharma, a generic drugs maker in the university town of Coimbra, the firm has continued to prosper.
In 2012, revenues jumped to 29 million euros from 18 million in 2011; it has hired 108 workers - all graduates - to take staff numbers above 300; and it exported 82 percent of its output last year, compared with 73 percent in 2011.
"For us, emerging markets are getting hotter. But we look around and we see companies that remain dependent on the internal market going through great difficulties," said Maria Isolina Mesquita, a senior manager at the firm.
Call centre company Teleperformance Portugal is also doing well. It added close to 1,000 jobs in the past 12 months and is looking to hire another 400. Revenues rose 40 percent in 2012.
Chief executive Joao Antonio Cardoso says Teleperformance is benefitting from the recession as mltinationals streamline their customer help lines, driving business his way. "We have a huge opportunity ...in a market that is absolutely booming," he said.
Contrasting Fortunes
The story is different at Volkswagen AutoEuropa, Portugal's second-largest exporter, which last year produced 15 percent fewer cars than in 2011.
The firm does not have enough work right now for about 600 of its 3,626 employees and so is assigning 200 of them temporarily to Germany and giving another 200 extra training. Thanks to flexible working practices, no one is being fired.
"We're facing a European crisis. Most of our customers are in recession with the exception of Germany," said Antonio de Melo Pires, the head of the plant, which exported nearly all of the 112,550 cars it made in 2012.
"There were hopes some months ago that things were going in the right direction, but lately it seems another crisis has sprung up," he added, referring to Cyprus's banking meltdown.
Indeed, the outlook for much of the Portuguese economy is so bleak that many businessmen fear their best employees will vote with their feet.
Tens of thousands of skilled youngsters have been emigrating in search of higher-paid jobs - either in Europe or in Portugal's former colonies such as Brazil and Angola, which is now the country's fourth-largest export market.
"There is always the concern that we will lose all these people," said Antonio Reis, technical director of Optimal Structural Solutions, a high-tech start-up near Lisbon that designs aeronautical parts and crash-tests Formula One cars.
Portugal is trying to pull up its socks. It plans to improve its port and rail infrastructure. It is playing to the strength of its links to Africa and Latin America. Its traditional textile and footwear industries are moving up the value chain.
Yet for all its resilience, Portugal is struggling to escape a past of poor competitiveness and low educational achievement. In the years after joining the euro, waves of easy credit masked these shortcomings. Now the tide has gone out.
"This will be the first generation whose children will live worse than we do," said Francisco Calheiros, president of the Portuguese Tourism Confederation.


text:
Adenosine 2A Agonist Lexiscan in Children and Adults With Sickle Cell Disease
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT01085201
Recruitment Status : Completed
First Posted : March 11, 2010
Results First Posted : March 7, 2014
Last Update Posted : March 7, 2014
Dana-Farber Cancer Institute
Brigham and Women's Hospital
Boston Children's Hospital
Washington University School of Medicine
Medical College of Wisconsin
Johns Hopkins University
La Jolla Institute for Allergy & Immunology
National Heart, Lung, and Blood Institute (NHLBI)
Astellas Pharma Global Development, Inc.
Information provided by (Responsible Party):
David G. Nathan, MD, Dana-Farber Cancer Institute
- Study Details
- Tabular View
- Study Results
- Disclaimer
- How to Read a Study Record
|Tracking Information
|First Submitted Date ICMJE
|March 10, 2010
|First Posted Date ICMJE
|March 11, 2010
|Results First Submitted Date
|May 2, 2013
|Results First Posted Date
|March 7, 2014
|Last Update Posted Date
|March 7, 2014
|Study Start Date ICMJE
|April 2010
|Actual Primary Completion Date
|February 2013 (Final data collection date for primary outcome measure)
|Current Primary Outcome Measures ICMJE
|Dose Limiting Toxicities as a Measure of Whether Infusional Lexiscan is Safe in Individuals With SCD. [ Time Frame: 30 to 54 hours plus 30-day follow-up ]
Per protocol, Lexiscan was considered "safe" if well tolerated based on number of DLTs reported. Stage 1 of the study was a 3+3 dose escalation study. Three doses were tested: 0.24 mcg/kg/hr (dose level 0), 0.6 mcg/kg/hr (dose level 1), and 1.44 mcg/kg/hr (dose level 2). Dose escalation continued until 6 participants were treated at the maximum planned dose (dose level 2). We studied a total of 15 patients in Stage 1. In Stages 2 and 3, if at least 2/3 participants tolerated the dose, an additional 3 participants were studied. We studied 6 participants in each of stages 2 and 3. In stage 2b, Lexiscan was studied for a longer (48 hr) duration in 3 participants. In stage 4, Lexiscan was studied in 3 pediatric participants.
|Original Primary Outcome Measures ICMJE
|To determine if infusional Lexiscan is safe in individuals with SCD. [ Time Frame: 2 years ]
|Change History
|Complete list of historical versions of study NCT01085201 on ClinicalTrials.gov Archive Site
|Current Secondary Outcome Measures ICMJE
|Original Secondary Outcome Measures ICMJE
|Current Other Outcome Measures ICMJE
|Not Provided
|Original Other Outcome Measures ICMJE
|Not Provided
|Descriptive Information
|Brief Title ICMJE
|Adenosine 2A Agonist Lexiscan in Children and Adults With Sickle Cell Disease
|Official Title ICMJE
|Safety of Adenosine 2A Agonist Lexiscan in Children and Adults With Sickle Cell Disease
|Brief Summary
|Sickle cell disease (SCD) is an inherited blood disorder that causes the red blood cells to change their shape from a round shape to a half-moon/crescent or sickled shape. People who have SCD have a different type of protein that carries oxygen in their blood (hemoglobin) then people without SCD. This different type of hemoglobin makes the red blood cells change into a crescent shape under certain conditions. Sickle-shaped cells are a problem because they often get stuck in blood vessels blocking the flow of blood, and cause inflammation and injury to the important areas in the body. Lexiscan is drug that may prevent this inflammation and injury caused by the sickle shaped cells. This drug is approved by the FDA to be used as a fast infusion during a heart stress test in people who are unable to exercise enough to put stress on their heart by making it beat faster. Lexiscan has never been studied in patients with SCD and has never been given as a long infusion.
|Detailed Description
|Study Type ICMJE
|Study Phase
|Phase 1
|Study Design ICMJE
|Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Condition ICMJE
|Sickle Cell Disease
|Intervention ICMJE
|Drug: Lexiscan
Given as an infusion
|Study Arms
|Publications *
|Field JJ, Lin G, Okam MM, Majerus E, Keefer J, Onyekwere O, Ross A, Campigotto F, Neuberg D, Linden J, Nathan DG. Sickle cell vaso-occlusion causes activation of iNKT cells that is decreased by the adenosine A2A receptor agonist regadenoson. Blood. 2013 Apr 25;121(17):3329-34. doi: 10.1182/blood-2012-11-465963. Epub 2013 Feb 1.
* Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
|Recruitment Information
|Recruitment Status ICMJE
|Actual Enrollment ICMJE
|Original Estimated Enrollment ICMJE
|Actual Study Completion Date
|March 2013
|Actual Primary Completion Date
|February 2013 (Final data collection date for primary outcome measure)
|Eligibility Criteria ICMJE
Inclusion Criteria Stage I/II/IIb: (COMPLETE AND CLOSED TO ACCRUAL)
Inclusion Criteria Stage III: (COMPLETE AND CLOSED TO ACCRUAL)
Inclusion Criteria Stage IV: (open, still accruing volunteers)
Exclusion Criteria Stage I/II/IIb: (COMPLETE AND CLOSED TO ACCRUAL)
Exclusion Criteria Stage III: (COMPLETE AND CLOSED TO ACCRUAL)
Exclusion Criteria Stage IV: (open, still accruing volunteers)
|10 Years to 70 Years (Child, Adult, Older Adult)
|Accepts Healthy Volunteers
|Contacts ICMJE
|Contact information is only displayed when the study is recruiting subjects
|Listed Location Countries ICMJE
|United States
|Removed Location Countries
|Administrative Information
|NCT Number ICMJE
|Other Study ID Numbers ICMJE
1RC2HL101367-01 ( U.S. NIH Grant/Contract )
|Has Data Monitoring Committee
|U.S. FDA-regulated Product
|Not Provided
|IPD Sharing Statement
|Not Provided
|Responsible Party
|David G. Nathan, MD, Dana-Farber Cancer Institute
|Study Sponsor ICMJE
|Dana-Farber Cancer Institute
|Collaborators ICMJE
|Investigators ICMJE
|PRS Account
|Dana-Farber Cancer Institute
|Verification Date
|February 2014
ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP


text:
I arrived back in Denmark and delved straight into Skam, which I had previously brushed aside as silly. I also received a gift from Down Under!
Days became short and the sun was low when I went to my Monday dancing.
I enjoyed Copenhagen in its' christmassy sparkles and hung out with the weird Disneys.
December came and me and Rasmus started the new DR julekalender. We kept watching over the next days, but even as he persisted I gave up on the weird fairy tale that had replaced christmas on the Danish television.
I went searching for a new winter coat. And spent two weeks on it, christ. Never egain.
I hung out with both Marias! I didn't really enjoy Raging Bull, but Maria is lovely so... And the other Maria had me stay in Cocks and Cows until we were almost the last ones there.
This year we only have one squirrel buddy. But he is very active and fun to photograph.
Kathrine had invited me to hang out and I happily accepted. On arrival, I was told we would be making gingerbread houses! Rasmus came late, so he just assisted our building projects. In the end, we all had caramel burns!
But the end result was lovely. I really liked how a light could illuminate the hard candy windows.
Sunday I was tasked to do even more Christmas baking as we made confectionery for hours at T&Ks..
I went to Glyptoteket again.
But left after a pretty short while to meet up with Emi! We were going to see the Lucia event that took place on the canals.
Then we went swing dancing and I stayed on to sketch and play table tennis!
Squirrel and star photos. Tina and I spent some hours on that little bump watching the shooting stars and only left when we were deeply frozen.
I drew and drew and drew and binged Merlin and Firefly.
Then I went by Gabi's shop after working a few days in a row. We talked, ate Christmas things and watched Love Actually in a big group.
We also went by Centralhjørnet (oldest gay bar in the world) to see their yearly decorations. I was tired from work though, so I went home after a little while and read Batgirl.
I took a seasonal bath.
And continued the tradition of going to Rasmus' on the 23rd. I helped Brian to do the decorating and we just had a nice time.
Christmas struck and I dressed up.
Going to the countryside for Christmas is almost cathartic at this point. At least in most cases.
We were an odd mix this year, but it was still lovely. And Jesus joined the party too...
We went by my uncle's too for relaxation and leftovers.
They are really the part of family where anything goes.
I ended the holidays at work (yay!) and got to eat risengrød super late this year. I was awarded a Scrabble win over even Louise for my patience?


text:
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text: They took the day off to attend the funeral of one of J.'s clients. Afterward, with several more free hours left, and three days after it became legal for them to marry in Florida, they headed to the old Hillsborough County Courthouse in downtown Tampa to apply for a marriage license.They wore black T-shirts with white lettering that read: "Engaged for 30 years." People cheered and gave them high-fives.Inside the clerk of court's office, a woman told them it was the last day the requisite three-day waiting period would be waived for couples who had not taken a state-approved preparatory course."You've waited long enough," she told J. Harrison and Mick Mosher. They completed outdated paperwork that had entries only for husband and wife."Do you ...?" the woman asked. "I do," the men said in turn. And, just like that, they were husbands."We did kiss at the desk, after it was all over," J. said. "We did have a few tears rolling down our faces."They had not planned to elope. "It was kind of a spur-of-the-moment thing," J., 59, remembered. He owns a hair salon in their home in Tampa's Carrollwood community."I had a client who passed away, a very loyal client. Mick knew her also, and he took the day off, and I said, 'That would be the perfect day to get the marriage license.' "Mick, 54, is an award-winning special-education teacher at Walker Middle Magnet School, an International Baccalaureate school in Odessa.A mutual friend introduced the men on Dec. 3, 1984, in Binghamton, N.Y. "About a year and a half later," J. remembers, "we helped his parents move to Lake Wales. I flew home, and it was 84 degrees when I left. Mick picked me up at the airport. It's, like, 30 degrees and raining snow. I said, 'I'm moving to Florida. You want to go with me?' We moved the next August, when our lease was over � Mick and myself and our dog, Daffodil, a basset hound."We rented a townhouse. We had a blow-up air mattress and the seats from our van as furniture. We were good customers of Goodwill and Salvation Army at the time."We just hit it off, and we've been together ever since. It's been good. We rarely argue. We're each other's best friends. I still can't wait till he gets home from work.""It's been a very good ride," Mick said. "We've both enjoyed it. For better or worse, we're in it together."Through their three decades together, they said, they didn't know whether they would ever be able to marry legally."It feels right," Mick said. "We've earned it. I introduce him as my husband. It feels so nice to be able to say that instead of 'partner,' or 'significant other.' I hate 'significant other.'�""We feel like newlyweds," J. said. "We feel closer. We say, 'Come here, husband.' We're just thrilled about it."With the civil ceremony accomplished, they plan a party and another wedding with family and friends on their 31st anniversary."After 30 years," J. said, "we need to have an event."Contact Mary Jane Park at (727) 893-8267 or [email protected]


text:
Ernie Ball Strings
Not sure if you've ever heard Ernie Ball strings in action before? You might be surprised! Ever listened to Metallica or Green Day? Then you've heard them - they're go-to choices for James Hetfield and Billie Joe Armstrong. And those are just two names from a roster that also includes Tom DeLonge, Slash, Kirk Hammet, The Edge, Angus Young, Jimmy Page and Buddy Guy. With a list of artists like that standing behind Ernie Ball strings, you know that they're something special even if you've never tried them out for yourself before.
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text:
When you're quiet enough, lost in the day dreaming of missed opportunities, you hear things. When all is quiet and you have a moment to think with regret the things you wished you would've done, should've done, could've done... when you think of all that might have been and you think with longing for the things that you thought would happen, but instead that you are still waiting for…in that moment when all is quiet and you're thinking on the memories and dreams…when it's that quiet, you can hear the sound your heart makes when it breaks.
"This time, like all times, is a very good one, if we but know what to do with it." — Ralph Waldo Emerson
About Me
- michelle
- Sometimes I dance around the living room with one hand waving free...
"With all its shame, drudgery and broken dreams, it is still a beautiful world…Be cheerful. Strive to be happy."
— Max Ehrmann
Thursday, December 9, 2010
It makes a sound, your heart does...
Posted by michelle at 1:33 PM No comments:
Amie Miriello Hey
Posted by michelle at 9:47 AM 2 comments:
Wednesday, December 8, 2010
I let you touch my face
And memories are coming back to me today, as I sit and write about you. There is so much I think about when I remember you; like how I've always hated it when my face was touched, but I remember your hands on my face, and how I didn't pull away. I remember my hand in yours and how your fingers fit around mine. I remember your smile and the way your whole face lit up when you talked of flying and music and what it was like to have moments when the voices stopped and you could just be happy. We loved the quiet moments and missed them, the fewer they got.
I write about you twice a year. On your birthday and every year around this time, because it's Christmas time, and you loved mistletoe and kissing….and I sit as the memories come flooding back, and have to smile at what was. It's only at these times when I think about all that was good that I am not sad about the time we missed out on, about all the memories that we didn't have.
You wanted to fly, and you wanted to play music. I wanted to watch all your dreams come true. I wanted to be there when they came true for you.
I don't like my face being touched, but I never minded it when you held my face in your hands… I'm remembering so much today, as I sit and write about you… you are some of my best memories…
Posted by michelle at 11:37 AM No comments:
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There is no use trying, said Alice; one can't believe impossible things. I dare say you haven't had much practice, said the Queen. When I was your age, I always did it for half an hour a day. Why, sometimes I've believed as many as six impossible things before breakfast.
I am the queen and this is my year, and nothing, NOTHING is impossible
I am the queen and this is my year, and nothing, NOTHING is impossible
Blog Archive
- ▼ 2010 (44)


text:
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Ecological restoration, the attempt to guide damaged ecosystems back to a previous, usually healthier or more natural, condition, is rapidly gaining recognition as one of the most promising approaches to conservation. In this book, William R. Jordan III, who coined the term "restoration ecology," and who is widely respected as an intellectual leader in the field, outlines a vision for a restoration-based environmentalism that has emerged from his work over twenty-five years.
Drawing on a provocative range of thinkers, from anthropologists Victor Turner, Roy Rappaport, and Mary Douglas to literary critics Frederick Turner, Leo Marx, and R.W.B. Lewis, Jordan explores the promise of restoration, both as a way of reversing environmental damage and as a context for negotiating our relationship with nature.
Exploring restoration not only as a technology but also as an experience and a performing art, Jordan claims that it is the indispensable key to conservation. At the same time, he argues, restoration is valuable because it provides a context for confronting the most troubling aspects of our relationship with nature. For this reason, it offers a way past the essentially sentimental idea of nature that environmental thinkers have taken for granted since the time of Emerson and Muir.
1. Weeding Key Biscayne
2. The Challenge of Reinhabitation
3. Paradigms of Community
4. Awareness: Restoration as a Way of Seeing, and as Work and Play
5. The Exchange: Restoration as Repayment and the Gift of Ecological Immortality
6. Value and Make-Believe: A Primer on Performance
7. Sacrifice and Celebration: Restoration as a Performing Art
8. Conservation and Community: Restoration, the Environment, and Environmentalism
Selected Readings
William R. Jordan III is Director of the New Academy for Nature and Culture and Co-director of DePaul University's Institute for Nature and Culture. He was senior editor of "Restoration Ecology: A Synthetic Approach to Ecological Research" and was founding editor of the journal "Ecological Restoration" and a founding member of the Society for Ecological Restoration.
Elevating ecological restoration beyond the basic technical aspects to encompass ethical and social considerations, Jordan forges an ambitious model for solving the environmental challenges that threaten native habitats.
- Booklist
"Like all enduring popular movements, environmentalism has been propelled by seminal thinkers and action figures. A century ago John Muir and Theodore Roosevelt got the ball rolling with their ardent championing of wilderness preserves and wildlife protection. Fifty years later Rachel Carson's Silent Spring helped expand the movement to include pollution and public health issues. Then there are the many and varied stars, from Aldo Leopold to David Brower to E. O. Wilson, whose legendary achievements have rallied millions to nature's cause. At some point, William Jordan, the intellectual leader of a relatively new but influential discipline-ecological restoration-is likely to join this pantheon."
- Audubon Magazine
"Argues that [ecological restoration is] vital to the preservation of the Earth's ecosystems, and to ourselves.... Thanks to Jordan's compelling and wide-ranging argument, we learn that [restoration] also is central to the project of being human."
- Orion
"Elevating ecological restoration beyond the basic technical aspets to encompass ethical and social considerations, Jordan forges an ambitious model for solving the environmental challenges that threaten native habitats."-Booklist
"This profoundly provocative and challenging book proposes nothing less than to change the focus of the American and indeed global environmental movement from `defense' to `offense.' It offers a bold, positive replacement for the thinking that has underlain the conservation and preservation movements from their beginnings. In fact, it makes a convincing argument for an altogether new relation between human beings and the natural environment."
- Ernest Callenbach, author of "Ecotopia"
"In this remarkable book, Bill Jordan, the preeminent philosopher of ecological restoration, essays nothing less than mooting the distinction between nature and culture. An argument so brilliant that it's a work of art, 'The Sunflower Forest' envisions evolution, ecosystems, and human action as integral, dynamic, and harmonious. Sage, erudite, and original, 'The Sunflower Forest' is bound to provoke and inspire."
- Stephanie Mills, author of "In Service of the Wild: Restoring and Reinhabiting Damaged Land"
"In a world where Nature is on the defensive and natural habitats shrink by the minute, ecological restoration offers the only hope for many species and ecosystems. As Bill Jordan explains in his wonderful new book, our taking the offensive to reclaim damaged lands, also restores our spirits."
- Stuart Pimm, Doris Duke Chair of Conservation Ecology, Duke University
"'The Sunflower Forest' is a highly original, thoughtful, and provocative argument for restoration as a new environmental paradigm. Jordan is a serious intellectual. The book captivated me-it could be the 'must read' book of the year."
- Max Oelschlaeger, Ecological Restoration Institute, Northern Arizona University


text:
Remember Me is hoping you'll save the date.
Summit Home Entertainment, the company who has the rights to the Twilight series on DVD and Blu-ray, are releasing the Robert Pattinson romance on both formats come June 22, 2010. The film was released as a quick cash-in for the Twilight buzz, trying to garner some money on the fame of Pattinson, the lead vampire in the Twilight saga. It faltered at the box office, though, not gaining the interest of the vampire-loving crowd and not taken seriously enough by everyone else, so it's looking to rebound on Blu-ray and DVD.
The releases will contain bonus materials and extra features, and the DVD will be available for the MSRP (Manufacturer's Suggested Retail Price) of $26.99, while the BD will cost you $34.99 at MSRP.
The Remember Me releases will feature the following bonus materials:
-- Audio Commentary with Robert Pattinson and cast
-- Audio Commentary with Director Allen Coulter
-- Making Of featurette
Check out the box art below:
Stay tuned to IGN DVD for more information about this and other upcoming releases!


text:
A 90-year-old Sarasota, Florida widow is facing thousands of dollars worth of fines for code violations.
Mary Louise Sikorski has called the little pink house on Webber Street home for decades. She's scared she'll lose it.
"We're concerned with how the city is acting," Sikorski said.
Her husband, a military veteran, died years ago. Since then, her house has fallen into disrepair. In recent years, the city issued numerous code violations and threatened to begin the foreclosure process.
[NBC26]© 2010-18 FORECLOSURE FRAUD | by DinSFLA. All rights reserved.


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|November 16, 2012, 01:57 PM
Junior Member
Join Date: October 23, 2012
Posts: 7
I hope some coyote hunters have ethics
I have hunted all my life, and as a teenager hunted some coyotes with mouth calls in Idaho. This despite my father's unique ethic of never shooting a predator of any kind. He had an indian-like respect for certain fellow creatures. But whatever your ethical viewpoint, there has to be a limit. I just watched my first episode of Foxpro Furtakers where three hunters, one a Ruger company executive testing out a new gun, were hunting coyotes with one of Foxpro's artificial recording calls. The first coyote was a big beautiful thing. The Ruger guy shot at it on the trot, with no real need, and obviously hit it in the right rear thigh. The coyote reacted like one of my dogs would, spinning in a circle biting at the bloody wound. They tried to track the wounded animal but gave up after 3 to 500 yards. But what really bothered me is that not one of these humans made any comment about the suffering they inflicted on this animal that, like a human, can enjoy life, have fun, have a family, and otherwise live a life. Instead they commented about what a bummer it was that the Ruger guy didn't get the varmint. Thats another thing that bothers me about humans when hunting something that has feelings. The try to de-animalize animals by calling them derogatory names. We have a whole "varmint" rifle industry out there advocating killing these incredibly intelligent creatures. Anyway, these three hunters got right back to hunting, bemoaning their "bad luck" and again called in (with their recording gadget they sell on the show) and shot a huge coyote in the rear quarters. This one again spun around in circles and then gave the most horrible open-mouthed cry up into the air that I have ever seen an animal make. Please understand that if you choose to kill these animals you should take standing shots, you should make sure the animal is killed more or less instantly with your new hyper-velocity rifle. And please leave true wilderness areas alone (this was not one). What is the purpose of flying into a wilderness area of Canada to shoot wolves or grizzlies that are doing nothing more than participating in a complex ecosystem? Shoot coyotes where they are obviously too numerous because their natural predator -- the wolf -- has been slaughtered by humans and their past reckless stewardship of nature. But do it humanely, and like the indians, acknowledge you have taken the life of a fellow intelligent creature.
|November 16, 2012, 02:15 PM
Senior Member
Join Date: November 24, 2010
Location: Spring, TX
Posts: 1,547
Coyote in some areas (like mine) are considered a nuisance to livestock. Killing them humane or not is not typically a concern in my neck of the woods. Dead is dead no matter how it is brought about. I am sure that If given the choice a hunter would shoot for the vital or head. However if you've hunted much coyote you'd know they aren't animals to move slowly. Sometimes a shot on the move is all you are presented with and so the opportunity is taken. As opposed to a deer where if the shot doesn't present itself you don't take it. Not taking that shot on a coyote might cost the landowner hundreds of dollars.
Your beliefs are your own and mine are mine. The country I live in allows me to believe differently than others. I understand your logic and stance on the subject but try and understand that of others as well.
|November 16, 2012, 02:33 PM
Senior Member
Join Date: January 23, 2010
Location: Vernon Texas
Posts: 474
Rip. I couldn't have said it any better myself. I agree to a tee with you. I run 60 head of cattle on a small family farm. Last year we lost 4 calves and 1 cow do to coyotes. I don't care where I shoot them. As long as they die. When it comes to my living or a dog.... Sorry the dogs gone.
|November 16, 2012, 02:36 PM
Senior Member
Join Date: September 21, 2010
Location: az
Posts: 1,258
"When there's lead in the air, there's hope in the heart"- Hunter's Proverb
"Feed me, or feed me to something. I just want to be part of the food chain." -Al Bundy
|November 16, 2012, 02:38 PM
Senior Member
Join Date: August 10, 2012
Location: Utah
Posts: 232
Coyotes and ethics
You might check the thread, "My Coyote Jihad". Some hunters, perhaps with some ethical reluctance, see the personal damage done to pets, kids, and domesticated animals in general as a serious nuisance, and take appropriate steps. Ecosystems change in ways that require human intervention to minimize the aforementioned damage as well as the bigger problem or disease and starvation.
These factors can and have decimated coyote populations, just as with other species. In the west, where I live, rabbits and hares can over-populate an area and diseased varmint carcass's will damage other species. As you'll see in the pictures, predation by coyote packs can be problematic for deer populations.
I agree with the concept of the 'sanctity of life'. I avoid shooting 'varmints' unless there is a need - for food or reasonable population control.
Without wishing to stir a political pot too much in a shooting forum, I can only hope that those who's moral position demands that others respect the life of a rabbit, groundhog, or coyote also show equal respect and concern for the defenseless among the human species.
(EDIT - Paragraphs added...! There, Ya Happy?!?)
"Figure Out What You Believe and STAND YOUR GROUND!"
Nemo Me Impune Lacessit
Lots of Cast Iron to Cook With...
and a few defensive firearms, too!
Last edited by smokiniron; November 16, 2012 at 08:50 PM.
|November 16, 2012, 03:00 PM
Senior Member
Join Date: September 6, 2011
Location: Wyoming
Posts: 1,320
Coyotes do not have "feelings" like people. The ethics of the TV show you cite aside, maybe you should not be a hunter?
Oh, and BTW, don't lecture me about hunting in wilderness areas.
Go Pokes!
Go Rams!
|November 16, 2012, 03:16 PM
Senior Member
Join Date: May 12, 2002
Location: MO
Posts: 5,206
Bait post.
May a person who is relocating out-of-State move firearms with other household goods? Yes.
|November 16, 2012, 04:07 PM
Senior Member
Join Date: August 25, 2008
Location: Potatoes and Hops
Posts: 11,385
Don't even try it. It's even worse than the internet would lead you to believe.
|November 16, 2012, 05:10 PM
Senior Member
Join Date: October 11, 2009
Location: Hansen Idaho
Posts: 1,465
You are preaching to the wrong crowed. Many of us live and hunt in wilderness areas. And as far as the wolf goes you take all you want and shove them where the sun don't shine. Many of us are sick of out of state people, many of which never even visit here, tell us in the west how to manage our wild life.
We used to have some really good elk and deer populations. Now we don't have hardly squat thanks to those **** who think they need to mind others business and affairs.
* (Swinging club) Whack! whack! whack! *
Nope, the old nag's still dead .
(Capt Charlie)
|November 16, 2012, 06:00 PM
Senior Member
Join Date: March 15, 2010
Posts: 6,857
Spinners, as they are called, are very common on predator hunting shows.
I kill many coyotes, yes it's fun, but the main reason is: they are brutal killers. Once you find a prized animal that you helped bottle raise with its guts strewn about, you stop admiring their beauty real quick.
The fact of the matter is, coyote populations continue to grow as we make more favorable conditions for them to flourish.
Coyote and pig control has no place for sportsmen.
That being said, I have never had a "spinner" because I will never take a long shot on them. Coyote hunting for sport is about making long shots. I tend to get close to them to shoot them. I shoot near livestock, so missing is not an option. Many coyotes suffer from mange so killing them before winter is doing them a favor.
|November 16, 2012, 06:02 PM
Senior Member
Join Date: August 14, 2011
Location: Brazos County, Texas
Posts: 1,038
My boss's daughter just killed a coyote....sure tore up the front of her Mustang though.!!
|November 16, 2012, 06:17 PM
Senior Member
Join Date: November 18, 2008
Location: Rocky Mountains of Montana
Posts: 282
Maker of Horse Tack and Cowboy Gear.
Mister, why do you carry a 45? "Cause Sam Colt don't make a 46."
Last edited by freedom475; November 17, 2012 at 06:04 PM.
|November 16, 2012, 06:25 PM
Senior Member
Join Date: March 15, 2010
Posts: 6,857
I would like to add that, coyote like canines are in every land around the world and we have been competing with them since the dawn of man, and hunting them is old as time.
|November 16, 2012, 06:40 PM
Senior Member
Join Date: November 18, 2008
Location: Rocky Mountains of Montana
Posts: 282
Maker of Horse Tack and Cowboy Gear.
Mister, why do you carry a 45? "Cause Sam Colt don't make a 46."
Last edited by freedom475; November 17, 2012 at 06:05 PM.
|November 16, 2012, 06:45 PM
Senior Member
Join Date: September 6, 2011
Location: Wyoming
Posts: 1,320
Why do we say things like "Animals kill for FUN"?
Animals don't kill for fun, they just kill! It is all instinct. They have absolutly no idea what "fun" means.
Other than that, I agree with you, freedom475.
Go Pokes!
Go Rams!
|November 16, 2012, 06:59 PM
Senior Member
Join Date: March 11, 2011
Posts: 321
Wile E. Coyote may be the last man standing whenever we manage to obliterate ourselves God forbid. The Coyote has pretty much sneered at all efforts to contain his number. He has expanded his range across the continent. He has bred domesticated dogs and the Red Wolf. He is thriving in New York City and the rural heartland. It is really a quite admirable accomplishment by any measure. None of this justifies animal cruelty. Nor do I think that any stockkiller should be spared. As far as him being obliterated. I doubt we need worry.
|November 16, 2012, 07:54 PM
Senior Member
Join Date: January 27, 2012
Posts: 1,078
If I get woken up at 03:00 one more time, I am going on a Jihad.
Between them howling and the dogs barking at them, it is next to impossible to sleep.
Since I can't kill the dogs, my wife won't let me, I will have to kill the coyotes.
They aren't native here anyway.
I shoot nuisance animals all the time.
Squirrels for chewing on my roof and getting into bird feeders, muskrats for digging in my dike, crows for waking me up in the morning, mice for just being mice, rabbits for eating garden flowers, ground hogs for digging up fields.
BECAUSE they are a nuisance.
I am no longer participating in gun forums.
Good luck.
|November 16, 2012, 08:01 PM
Senior Member
Join Date: October 4, 2007
Location: All the way to NEBRASKA
Posts: 8,508
TheGolden Rule of Tool Use: "If you don't know what you are doing, DON'T."
|November 16, 2012, 10:12 PM
Join Date: August 19, 2011
Location: Lower Alabama
Posts: 28
sissyhunter, maybe you should look up this guy. I think he is somewhere in Utah.
NRA Endowment Member
|November 16, 2012, 10:42 PM
Junior Member
Join Date: October 23, 2012
Posts: 7
Higher mammals like coyotes, wolves and bears don't think like humans and can't use a keyboard, so we should kill them by any means? Anthopomophic? Animals that prey on the cows and sheep should be killed no matter what the method or suffering imposed? Coyotes are hard to hit so just shoot away -- hey, you can't eat them anyway. These are common beliefs, passed down by the varmint industry and unscientific and untruthful ranchers -- the same ranchers who won't let the public on their land to shoot all the varmints eating up their cattle. We all have dogs, so I noticed no one tried to say coyotes don't have fun or don't enjoy life. I think we were all born with a conscience that told us that inflicting unnecessary suffering was bad. What is wrong with allowing that conscience to take root again, even though all the unscientific, biased, knee-jerk reactionarys try to convince us that having a conscience is for fairyland. Am I anti-human? No. I've heard that term from unscientific, creationist zealots who point to their god after killing an animal. I'm not anti anything but meaness and stupidity. When humans say and do things I'm ashamed of, I'm entitled to call them what they are. Who do the animals have advocating for them? Why is it so bad that some humans will acknowledge the reckless stewardship that defines the European relationshp with nature and animals. When humans wise up and take responsibility, I'll stop advocating for ethical shots. I'm not anti-hunting. In fact, I believe hunting results in "ethical meat", which is the opposite of "unethical meat". Ethical meat comes from animals killed quickly and humanely after having an opportunity to have a decent quality of life. An elk shot through the lungs, which dies within minutes, creates ethical meat. A pig forced to live in a metal cage in which it can not turn, artificially inseminated, fed hormones and antibiotics and having its teeth and hooves cut to prevent it from hurting itself when it is driven insane, is an example of an unethical meat source. A pig raised in a barnyard where it sees the sun, socializes with its own kind, and has a decent quality of life before being butchered is a source of ethical meat. We allowed a class of Harvard 1970s-80s consultants (I can point to the actual names of the consulting companies) convince us that "sum zero" (profit above all else) ethics were good for us. This created State Farm, Enron, and Exxon-type companies. Those in the goods market, like Walmart, not only sold Chinese goods, but affirmatively went to China to make everything they could get made there, abusing the people already working for slave wages in the process. But the sum zero mentality flowed over into mechanized meat production, fogetting that we were dealing with living, feeling fellow creatures with no natural defense against greed. If we paid an extra nickel or two a pound so that creatures did not have to suffer, would we be so financially devastated. Would it be so bad if we ate 20 lbs less of unethical pork every year. I advocate for any higher mammal made to suffer by human meaness and greed.
|November 16, 2012, 11:06 PM
Senior Member
Join Date: March 15, 2010
Posts: 6,857
I'm hunting coyotes for a rancher at this exact moment. Most of us don't wanna make a bad shot especially with the two dollar bullet most likely loaded in 1000$+ rifle
But... Lets not pretend bad shots don't happen.... But, I like the above post about life not being Disney.
If a spinning coyote gets you worked up, don't watch bow hunting shows.
You should see an animal that has been ham stringed by a coyote, or had its guts ripped out for no reason. That will bring the honesty to the ranches lol.
I guarantee that those hunters you saw probably went on ten hunts where they didn't get nothing before they shot one.
|November 16, 2012, 11:10 PM
Staff Lead
Join Date: November 13, 1998
Location: Terlingua, TX; Thomasville, GA
Posts: 24,634
sissyhunter, the ad valorem tax man doesn't care if a rancher turns a profit or not--but the rancher either pays his school taxes or learns all about foreclosure and the sheriff's tax sale.
To people in ranch country, who generally have concern for their neighbors' well-being, ethics and coyotes are about like ethics and mosquitos, flies and cockroaches. There aren't any.
So call this a reality check. There is no correlation whatsoever with the ethics and morals of hunting game animals.
You're from BATFE? Come right in! I use all your fine products!
|November 16, 2012, 11:13 PM
Senior Member
Join Date: September 21, 2010
Location: az
Posts: 1,258
You're mad because the bad shot wasn't acknowledged? Bad shots happen, it's part of hunting. It doesn't mean they enjoyed making the animal suffer or that they didn't care at all. They probably decided it wasn't good TV to whine about how much the coyote suffered because homeboy made a bad shot. Doesn't mean he meant to hit it bad, and it doesn't mean he doesn't care. It also doesn't mean that what made the final edit was all the time they spent looking for it. Maybe next time he'll wait a little longer for a better shot. Or maybe next time he'll shoot it again while it's spinning.
Way too many "maybes" to get your panties in too big a twist over it. In my opinion, of course.
"When there's lead in the air, there's hope in the heart"- Hunter's Proverb
"Feed me, or feed me to something. I just want to be part of the food chain." -Al Bundy
|November 16, 2012, 11:27 PM
Senior Member
Join Date: March 14, 2010
Location: Border of Idaho & Montana
Posts: 2,532
Humans often put emotion on animals. I wonder if animals do some thing similar when the kill other animals? It does not seem to stop them...
Shot placement is everything! I would rather take a round of 50BMG to the foot than a 22short to the base of the skull.
all 26 of my guns are 45/70 govt, 357 mag, 22 or 12 ga... I believe in keeping it simple. Wish my wife did as well...
|November 17, 2012, 12:02 AM
Senior Member
Join Date: October 11, 2009
Location: Hansen Idaho
Posts: 1,465
Animals only know a few things, eat, drink, shelter, and reproduction. And they do not think of reproduction in the way we do. They breed because of instinct nothing more. If you doubt that, then watch animals during breeding season, while the females are either chasing last years young away or she is busy trying to keep a male from killing her newest so he can breed her again.
* (Swinging club) Whack! whack! whack! *
Nope, the old nag's still dead .
(Capt Charlie)
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Illustration BA (Hons)
What makes Illustration at Worcester special?
Illustration is a visual language, and has a relationship with the text it addresses - each half of the partnership has different moves, but they have to work together.
At Worcester, you can be part of the global picture. With our emphasis on international collaboration and real-world experience, youĀwill have the opportunity to develop your ideas and your portfolio, and will also haveĀevery chance to show them off in public exhibitions. Industry links with major illustrators and publishers from around the world, such as Axel Scheffler, means you can be a part of the international illustration community from day one.
Read the Worcester Illustration Course Blog.
Key features
- Work to real-world briefs provided by professional publishers
- Home of the International Centre for the Picture Book in Society
- Award-winning lecture staff have extensive experience as professional illustrators
- Opportunities to exhibit your work nationally and internationally. FieldĀtrips within the UK and overseas
- Celebrate your achievements and showcase your talent with our final year Degree Show, housed within the Georgian splendour of the Charles Hastings Building andĀshare your work with top industry professionals
Entry requirements
What qualifications will you need?
UCAS tariff points
Entry requirements
104ĀUCAS tariff points
Shortlisted applicants may be invited to attend an interview and to provide a portfolio for consideration
Other information
If you have any questions about entry requirements, please contact the Admissions Office on 01905 855111 or email firstname.lastname@example.com for advice.
Further information about the UCAS Tariff can be obtained from http://www.ucas.com
If you are an international student who does not have the relevant entry requirements for direct entry onto this course, our pathway courses at University of Worcester International College could be the right option for you and enable you to still graduate with this degree. To find out more visit the Art and Design & Creative Media pathway page.
Some recentĀstudent work
Book your place at an Open Day
Want to know why so many students love living and studying in Worcester?
Our open days are the perfect way to find out.Book your place
Course content
What will you study?
Our courses are informed by research and current developments in the discipline and feedback from students, external examiners and employers. Modules do therefore change periodically in the interests of keeping the course relevant and reflecting best practice. The most up-to-date information will be available to you once you have accepted a place and registered for the course.ĀIf there are insufficient numbers of students interested in an optional module, this might not be offered, but we will advise you as soon as possible and help you choose an alternative.Ā
Year 1
Year 2
Year 3
Accommodation: Your home from homeFind out more
With over 1,000 single-occupancy rooms across our campuses, we offer contemporary accommodation to suit a variety of budgets and needs.
The International Centre for the Picture Book in Society
The International Centre for the Picture Book in Society is a new centre being developed by the University of Worcester. Its aims are:
- To provide an international focus in the UK for theĀmaking and study of the picture book, defined in their broadest sense (children's books, comics, hand-made books, 'zines, educational books, e-books and graphic novels)
- ĀTo promote a multi-cultural approach to engaging 'society' in its broadest terms with picture books, embracing minorities and socially disenfranchised people
To nurture new UK awareness of non-Anglophone picture book making, establishing a platform for showcasing picture books published across the globe.
Visit the Centre's website to find out more
Case study
Cheryl Howard
Cheryl Howard is the 2013/14 winner of the Worcestershire County Council Illustration scholarship. Her work was exhibited in the New Art West Midlands exhibitions (Birmingham Art Museum and the Barber Art Institute) as well as in the Creative Quarterly in New York. Cheryl says of her experience on the course:
ōThe support and advice on the Illustration course at Worcester have enabled me to discover strengths in my own visual language. Through embracing the modules to try different media, including print making and collage, it challenged me to understand different briefs and what would enable a strong visual concept.ö
Case study
Kathryn Martin
Since graduating from the University of Worcester, Kathryn Martin has been studying for an MA in Visual Communication at the Royal College of Art in London. During her first year at RCA, she has participated in two pop up exhibitions at the university, and will have work published in the first issue of a new graphic newspaper, Modern Times. Kathryn says about her years in Worcester:
"Without Worcester Illustration, I would not be at the Royal College of Art. During the three years of my BA, I was introduced to many different ways of thinking and working by excellent tutors who not only supported me, but gave me the freedom to play with my own ideas and research to reach something new. This level of freedom, especially during my third year, not only helped me get the most out of the direction I wished my work to go in, but prepared me for the self-directed nature of the MA course I am on now."
Teaching and Assessment
How will you be taught?
Teaching and Learning
The University places emphasis on enabling students to develop the independent learning capabilities that will equip you for lifelong learning and future employment, as well as academic achievement.Ā A mixture of independent study, teaching and academic support through the personal academic tutoring system enables you to reflect on progress and build up a profile of skills, achievements and experiences that will enable you to flourish and be successful.
You are taught through a combination of practical workshops, lectures, seminars and tutorials. Theory and context is embedded within practical sessions supporting students practice led research. A strong emphasis is placed upon students developing their own unique visual language ¢ learning programs designed to support communication, technical and research skills provide the basis for this.
In addition, meetings with personal academic tutors are scheduled on at least 4 occasions in the first year and three occasions in each of the other years of a course.
You have the opportunity to study abroad for a semester in the second year of the course. Further to developing your professional practice, many opportunities to work on live briefs and national/international competitions are provided. This is also supported by our outstanding visiting speaker program which takes the form of lectures, seminars and portfolio reviews.
You use industry-standard design software and have access to printmaking, 3d model making and lasercut facilities throughout the course.Ā
Contact time
In a typical week you will have around 15-16 contact hours of teaching.Ā The precise contact hours will depend on the optional modules selected and in the final year you will normally have slightly less contact time in order to do more independent study.
Typically class contact time will be structured around:
- 4 hours of formal lectures
- 2 hours of demonstrations
- 10 hours of supervised studio practice
- typical class sizes range between 15 ¢ 22 students
Independent self-study
In addition to the contact time, you are expected to undertake around 12 hours of personal self-study per week.Ā Typically, this will involve accessing reading lists and online resources, researching in the library and online, group task work, preparing presentations and developing personal sketchbook practice.
Independent learning is supported by a range of excellent learning facilities, including the Hive and library resources, the virtual learning environment, and extensive electronic learning resources.
Teaching staff
You are taught by lecturers who, themselves, are also professional, published illustrators working across editorial, publishing, advertising and authorial practices. Your learning is also supported by our technical team who provide demonstrations, tutorials and workshops.
Teaching is informed by the research and consultancy, and 60 per cent of course lecturers have a higher education teaching qualification or are Fellows of the Higher Education Academy. You can learn more about the staff by visiting our staff profiles.
The course provides opportunities to test understanding and learning informally through the completion of practice or æformativeÆ assignments.Ā Each module has one or more formal or æsummativeÆ assessments which are graded and count towards the overall module grade.
Assessment methods include a range of coursework assessments such as learning reports, portfolio submissions, interviews, presentations and a final year independent studies project.
The precise assessment requirements for an individual student in an academic year will vary according to the mandatory and optional modules taken, but a typical formal summative assessment pattern for each year of the course is:
Year 1
- Portfolio of practical outcomes
- Sketchbook submissions
- Critical learning reports
Year 2
- Portfolio of practical outcomes in response to set briefs
- Sketchbook submissions
- Critical learning reports
- Individual or group presentations
Year 3
- Major independent study project comprising of a portfolio submission containing practical outcomes, supported by a critical report
- Portfolio of self-directed projects
- Critical learning reports
You will receive feedback on practice assessments and on formal assessments undertaken by coursework. Feedback is intended to support learning and you are encouraged to discuss it with personal academic tutors and module tutors as appropriate. We aim to provide you with feedback on formal course work assessments within 20 working days of hand-in.
Arts facilities
Meet the team
Here are a few of the current members of the department who you may meet when you study this course. Visit the Humanities & Creative Arts 'Meet our Experts' page for the full list of department staff.
Tobias Hickey
Tobias Hickey lectures in illustration, drawing and printmaking. Graduating with a degree in Graphic Design from Liverpool Polytechnic in 1992 and subsequently gaining his MA Illustration from Central St Martin's College of Arts and Design in 1995.
Tobias initially took on commissions to illustrate children's books. His freelance practice then broadened into design and advertising and he became an established editorial illustrator, with regular commissions for The Guardian, The Times The Observer and The Independent newspapers. Other clients include You magazine, The Evening Standard, GQ Magazine, The Lawyer, The Daily Telegraph, TES, Sky Broadcasting, British Airways, Vodafone, Reader's Digest, Harper Collins and Conran Design. His illustrations have been published throughout Europe and in Australia.
Andy Davies
AndyĀgraduated with a first class degree in Illustration from Loughborough University in 2004, and then completed a MA Art and Design in 2008 at the same institution.
AndyĀhas a successful freelance practice, and works for clients around the world. His work has has been used in an editorial context by the Independent on Sunday and Guardian newspapers, in viral marketing campaigns for Vodafone, and for several successful book titles. Andy's work is regularly included in peer reviewed publications and he has exhibited in Britain and Italy.
Final Year Art ShowsVisit the website
The Worcester Degree Shows are the culmination of work from students on the University of Worcester's arts courses.
Where could it take you?
Illustrators are in increasing demand as the media industries expand. Options for the professional illustrator include newspapers and magazines, books, advertising, exhibiting independent work, television and the internet. All these fields are potential showcases for graduatesÆ work.
Our interdisciplinary approach gives flexibility and a wider view of the world that is attractive to employers. Graduates will find career opportunities not only in illustration but also graphic design, teaching, story writing, studio management, concept illustration for animation and games and advertising.
The course also provides an ideal basis for postgraduate study.
Request or download a prospectusRequest now
How much will it cost?
Full-time tuition fees
UK and EU students
The standard tuition fee for full-time UK and EU students registering in the academic year 2019/20 will be £9,250 per year.
For more details, please visit our course fees page.
International students
The standard tuition fee for full-time international (non-EU) students registering in the academic year 2019/20 will be £12,400 per year.
For more details, please visit our course fees page.
Part-time tuition fees
UK and EU students
The standard tuition fees for part-time UK and EU students registering on this course in the academic year 2019/20 will be £1,156 per 15-credit module, £1,542 per 20 credit module and £2,313 per 30-credit module.
For more details, please visit our course fees page.
Additional costs
Every course has day-to-day costs for basic books, stationery, printing and photocopying.ĀThe amounts vary between courses.
If your course offers a placement opportunity, you may need to pay for a Disclosure &ĀBarring Service (DBS) check.
Finding the right accommodation is paramount to your university experience, and our welcoming student communities are great places to live and study.
We have over 1,000 rooms across our hallsĀof residence. With roomsĀto suit every budget and need,Āfrom our 'Traditional Hall' at £102 per week toĀ'En-suite Extra' at £165 per week (2019/20 prices).
For full details visit our accommodation page.Ā
How do you apply?
Applying through UCAS
Single Honours:
Illustration BA - W220
Joint Honours:
See ourĀIllustration degrees page for Joint Honours options.
UCAS is the central organisation through which applications are processed for entry onto full-time undergraduate courses in Higher Education in the UK.
Read our How to apply pages for more information on applying and to find out what happens to your application.
Get in touch
If you have any questions, please get in touch. We're here to help you every step of the way.
Admissions office
01905 855111
Course leader
Tobias Hickey


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Thank You and Goodnight
Hey, listeners!
Sorry it's been so long since you last heard from us. After a lot of thought and conversation, we've decided to retire from the podcasting game. This announcement is long overdue, owing to the rest of life getting in the way, but after three years of feels, House sorting, recommendations, Youth Media Awards, bad tv, good tv, Real Ladies, superhero costume analysis, and feminist agendas, we just feel like this project has reached its natural conclusion. If you miss us, you can find us on Twitter @justplainbecca and @rooflizard or in the upcoming book Here We Are: Feminism for the Real World, edited by Kelly Jensen. While This Week in Ladies may be over, we'll never stop obsessing over popular culture or fighting the good fight for feminism, so follow us if you're into that kind of thing (or cats and dogs. or cheese. or Secretary Clinton's pantsuits.) Thank you for listening, commenting, and sharing. This was a labor of love and an absolute delight and we couldn't be happier that for a while we were able to share our conversations with you.
~Allison & Becca


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Rajasthan Vidyalaya Sahayak Syllabus 2015 Rajasthan Vidyalaya Sahayak Selection Procedure 2015 Rajshiksha Vidyalaya Sahayak Merit List Cut-Off Marks School Assistant Written Test/ Interview
Rajasthan Vidyalaya Sahayak Exam Syllabus/ Selection Criteria 2015
Application were invited by Director, Elementary Education, Rajasthan Bikaner for recruitment to 30522 posts of Vidyalaya Sahayak (School Assistant) in Non-Scheduled Area and 2971 posts in Scheduled Area under the provisions of Rajasthan School Assistant Subordinate Service Rules, 2015.
As we all know, there are a huge number of vacancies and the minimum qualification is only Intermediate (12th). So, it is sure that enormous candidates have applied against this Rajasthan Vidyalaya Sahayak Recruitment 2015.
All the aspirants who wants to become a school assistant in Rajshiksha must be anxious about the selection of these 30522 and 2971 Vidyalaya Sahayak posts. So, here we are going to discuss all the queries stuck in your mind. "How will they make Vidyalaya Sahayak Merit List?", "On what base the selection procedure will depend?", "What will the Vidyalaya Sahayak Syllabus, Exam Pattern & Selection Process", Written Test Marks/ Interview Marks criteria and cut-off marks etc.
►► Selection of Vidyalaya Sahayak will be purely based on Merit List. Merit List will be prepared on the basis of Marks of candidate in Inter, Experience and Interview.
Rajasthan Vidyalaya Sahayak Merit List –
1. 70% of Marks obtained by the candidates in the Inter (12th class) will be taken.
2. Bonus marks will be added to 70% of Inter marks for the experience as –
(a) for more than 01 year but less than 02 years – 05 marks
(b) for more than 02 years but less than 03 years – 10 marks
(c) for 03 years or more than that – 15 marks
3. After that 05 candidate against 01 vacancies will be provisionally admitted for the Interview in order of Merit (12th marks + experience). Interview will be 15 marks.
Clarification – Only 12th marks will be considered in making of Merit. No preference will be given to Higher qualification.
In case of Tie –
If two or more candidates get equal marks in merit list then preference will be given on basis of Date of Birth after that Higher qualification.
Click Here to Download Rajasthan Vidyalaya Sahayak Selection Process in Hindi
For More Details – http://www.vs.rajshiksha.rajasthan.gov.in/
Candidates can share their query or confusion related to Rajasthan Vidyalaya Sahayak Syllabus 2015 in the comment box given below.


text: I once thought only MS-Windows had "service packs", but today on an advertisement here on Linux.org, I learned that OpenSUSE also has service packs (major upgrades and added features). https://www.suse.com/promo/sle11sp3.html https://www.suse.com/company/press/2013/7/suse-linux-enterprise-11-service-pack-3-released.html Is anyone aware of other service packs in GNU/Linux of other Unix and Unix-like systems? I made this post and shared these links because I thought some of you would find it interesting. (Log in to hide this advertisement)


text: Trust: How to get it back after the Global Financial Crisis UQ Business School engaged Dr Graham Dietz and Dr Nicole Gillespie for a study on Building and Restoring Organisational Trust, and found three characteristics leaders need to build trust: Competence – the knowledge, skills and experience to do the job Benevolence – people want to feel their leaders have their best interests at heart Integrity – the adherence to a set of clear principles such as honesty and fairness Ultimately, trust can only be created by behaving in a trustworthy manner on a consistent basis and delivering on integrity, competence and benevolence. Trust arises through respect, transparency, knowledge and diversity of ideas and influence. These are not new concepts.They are fundamental aspects of our true nature. To access them, we need to 'unlearn' many of the stereotypes we have been taught about business. In particular, we need to unlearn that control and command systems are effective, that secrecy and deceit enhance value, and that benevolence and integrity are actions that business often associates with weakness or naivety. To restore trust in modern-day commerce, financial services firms need to change customer perceptions around ruthless, manipulative or hard-talking advisors being good for business.For wealth professionals, it starts with better questioning at the customer interface to understand their needs and concerns more fully. Recommend less than the absolute maximum tolerable risk, and you will find, in the long run, your trust will be rewarded.read more > 1 2 3 SHARE


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WRBT Magazine Issue 014
The 14th issue of WRBT Magazine is a full color, 40 page magazine at 5.5" x 8.5". Issue 014 cover art features the talented photography of @bonafidehigh. Issue 014 includes interviews with Groe, Faze, Lyric One, Keptoe and Kovet. Also includes our Tribute section with Vandel and Tead, Moniker Mayhem, and Unlucky 13 with Asic. Professionally printed, in full color quality. Available in Limited quantities so act fast.t.
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It has been researched and established over the last couple of years that it takes five times more to acquire a customer than to retain an existing one. Today in the retail world, it is difficult to acknowledge everything that's happening around the customers. In such a scenario, retailers cannot afford to ignore the need to constantly connect with consumers on multiple channels and touch points simultaneously and also interchangeably. Looking at the current trends, retailers need to overhaul their loyalty programs in order to create a personalized shopping experience.
1) The mobile wallet - As per Forrester Research, mobile payments will amount to $90 billion by 2017! *
2) More personalized in-store experiences for shoppers
3) Omni channel Retailing
2) More personalized in-store experiences for shoppers
3) Omni channel Retailing
Achieving Omni-channel customer loyalty is possible only by engaging with customer thorough pertinent evolving campaigns, promotions, offers and communications across all sales channels across all touch points of the shopping experience that resonate with the customer expectations. Distributing the right information at the right time and in the right context can be fruitful in terms of optimising the relevance and return of all loyalty marketing exercises. Such loyalty programmes promote cross-channel engagement which further buttresses customer engagement.
As consumers get addicted to new technologies and start making purchases across different channels, loyalty campaigns are taking the shape of an ever changing riddle, with marketers facing the challenge of creating an integrated picture from a mass of disparate data points.
Such sound loyalty management practices will ensure that customer-centric marketing initiatives across the purchase cycle - customer acquisition, customer development and customer retention, lead to improved control over customer's progress and in overcoming most of the loyalty challenges through the life cycle stages. Considering the universe of customers at the centre, every customer can be bucketed into one or the other category of loyalty lifecycle as demonstrated in the diagram below:
Given the fact that loyalty management is still in the nascent stage with respect to exploitation of technology and also given that many businesses and loyalty programs, aren't equipped enough to inspire a fresh breed of customer loyalty, there is ample scope for retailers to re-invent their loyalty programs at every stage of the customer lifecycle. Here are a few scenarios of customers in different stages of the lifecycle and how digital loyalty programs can be used with them:
• Would it take really much to delight a prospect with a personalized text on her mobile, offering a free product of her requirement?
• How about flashing the point balance with every text to a responder (prospect responding to a loyalty promotion)?
• How about re-welcoming the former customers with customized offers (based on their preferences / purchase history) delivered directly to their mobile phones?
Better and optimal use of technology will not only grow the number of loyal and new customers but will also build visibility and advocacy for the brand. It will help to further lift product specific sales and promote sales during slow periods, eventually generating returns on the capital invested in loyalty systems and programs.


text: Stories + Cases Community Healthcare Industrial B2B Research and Strategy Interactive Content Marketing SEO Branding One Website. Infinite Possibilities. Interactive Leading Healthcare into a Digital Future Interactive A Campaign to Correct the Conversation Branding Powerful Marketing for an Energy Industry Innovator Branding Fisher-Titus Medical Center Brand Refresh Branding Ohio Valley Surgical Hospital Re-Brand & Website Branding Healthcare Marketing for Kettering Health Network Branding Packaging Manufacturer Welcomes Traffic Boost After Site Relaunch Interactive Blending History + Leadership to Create a Robust 75th Anniversary Marketing Campaign Content Marketing Trupointe Takes Ag Data to the Field Interactive Website Brings Forthcoming Dublin Development to Life Interactive Jumping into a New Brand and Responsive Web Design Community Restructured Site Architecture Improves Usability B2B The Story of Us – A Brand Anthem Video Content Marketing Ohio Manufacturer Generates Considerable New Business SEO Upward Helps Consumer Brand Address Negative Reviews at the Source Content Marketing Juzo Transforms Social Media Presence in 1 Month Content Marketing Multinational Crane Manufacturer Turns Site Structure Headache into Opportunity SEO Upward Ace Sleep Apnea Treatment Launch SEO Brand Captures Dayton's Entrepreneurial Spirit Branding Mixing Product Identities to Create a New, Unified Brand Architecture Branding


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Instructor Gary Gabisan towers over his students. He's even more intimidating because he's armed with a two-and-a-half foot long rattan stick. And he's about to attack.
It's ok though, his students know what to do. They're practicing the Filipino martial art of Eskrima, which came to the U.S. decades ago.
"The first entry point for Eskrima was the farmworkers, also known as the 'manongs' who traveled here to work on the farms and to pick. And this was also their pastime," Gabisan says.
Gabisan's students are located south of Griffith Park in Los Angeles. They're paired off with two sticks a piece and taking turns striking at and blocking each other.
Erwin Mosqueda is an all-around martial arts expert. He owns a Tae Kwon Do school in Redondo, but he's really a master of Eskrima. He's trained under the best, he's won several world championships, he's the guy to learn from in these parts, and yet he doesn't have a traditional school to teach in.
For the past six years, he's been teaching in parks and other public places, and he doesn't charge for these classes.
"I'm a ninth degree blackbelt. I started this martial art when I am seven years old," said Mosqueda. "It's a hobby. It's my hobby."
Watching drills is nice, but to really experience a stick fight, you've got to see the sparring.
It looks like a mess. The combatants launch themselves at each other, just battering at heads, arms, chests — whatever's available. They're wearing protective gear, which is the only reason reporter Jed Kim was willing to give it a try.
A nice guy named Epifanio lets Kim borrow his gear. There's a padded helmet with metal bars protecting the face, large padded gloves cover his wrists and hands, and a thick padded vest shields his core.
After he's fully outfitted, he looks like a Nerf samurai.
His first opponent is Gabisan. Luckily, with all the gear, it doesn't hurt when Gabsian smacks Kim in the ribs with his stick. It's pretty obvious that Gabisan is taking it easy on him.
"It takes time. I'd say if you practice regularly for two years, you should be … good enough," said Gabisan.
Two years is a long time. Perhaps the best thing for Kim to do the next time a big guy with a stick comes after him is just run away.


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Vanilla, open-source Android available for 10-inch tablet on Sony GitHub
Like the Xperia Z before it, Sony has announced that it's bringing the Xperia Tablet Z into its version of the Android Open-Source Project (AOSP). The project brings the latest vanilla Android 4.2.2 Jelly Bean to the tablet, with the caveat that it's not "certified or intended for daily use," and many of the features from the shipping ROM will be missing.
You'll also need to do a bit of legwork yourself if you want to get AOSP up and running on your Xperia Tablet Z. The code is available on the Sony GitHub, just as it is for the Xperia Z, but you'll need to download and compile it yourself. So this is by no means a quick, easy fix to turn the Tablet Z into a Nexus-style device, but active development from Sony -- not to mention community developers -- could eventually make this a tablet of choice for Android hackers.
You'll find more technical details over on the official Sony blog, linked below. The Xperia Tablet Z is already available in some countries around the world. The Sony U.S. store is currently taking pre-orders, with an estimated ship date of May 24.
Source: Sony Blog


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Wintering Your Home eBook (PLR)
What? Save Money How can I save money when the heating bills continue to increase?
Discover How You Can Save Money On Your Heating Bills From Now On!
In this report, you will discover:
* How to conduct your own energy audit
* How a professional energy audit is performed
* How to seal air leaks
* What a tankless water heater can do for your home
* How to insulate a water heater
* Where you can use window treatments
* What caulking can do for your home
* What weatherstripping can do for your home
* How air sealing can decrease your heating bill
* How you can benefit from a whole-house systems approach
* How a barrier helps to keep heating costs down
* The meaning of the R-value
* Why the Federal Government requires R-value labels on all insulation products
Product Rights:
Includes Private Label Rights
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Keywords: energy;environment;green;lawn care
File Size: 265 KBytes
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