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Rainbow of Colour
Melissa G. Meiselman 10/21/2006 8:29:32 PMThe colors and lighting are totally awesome...terrific turquoise curves...seeming to pop out of the image...Just fantastic, Jennifer!!! #543973
Jennifer Carroll 10/22/2006 7:33:53 PMThank you so much Melissa for taking the time to comment on this image. Its one of my favourites :) #3486751
Corinne M. Thompson 10/21/2007 7:49:32 AMWonderful composition and colors! #4956468
Jennifer L. Alder 10/29/2007 6:21:36 PMVERY cool! Terrific light, color and perspective, Jennifer
Jennifer L. Alder 11/26/2007 5:34:00 PMCongrats on this wonderful finalist, Jennifer! :) #5129420
Robert Baer 11/27/2007 2:41:42 PMlove the lighting and pov. congrats on this creative finalist!! #5137417
Cesar J. La Rosa 11/27/2007 8:19:16 PMCongratulations on this well-deserved Winner, Jennifer!!!
Jennifer L. Alder 11/27/2007 11:46:07 PMCongrats on your win, Jennifer! :) #5140336
Stan J. Bendkowski 11/28/2007 1:10:47 AMGreat photo, Jennifer! Congratulations on your wonderful win. #5140545
Mitchell S. Speert 11/28/2007 8:30:46 AMCongratulations on your award! This image is fantastic. I love the colors and dimensionality of it. A very unique way of looking at a very ordinary object. #5142571
Jennifer Carroll 11/28/2007 2:57:06 PMThank you all so much for your wonderful comments. This was a complete surprise and so pleased you all liked this image. :) #5144086
Abstract shot of a multi coloured Slinky
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Uploaded on 10/20/2006 6:18:21 PM
Camera: Nikon D70 Digital SLR Camera
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815-556-2704 or E-Mail Us *free s&h on all domestic orders over $75
VERY FINE/NEAR MINT(W) Joe Harris (A/CA) Megan Hutchison'CHILDREN OF THE BEAST,' Part Three There once was a metal band called Shiloh. They didn't have much use for hairspray, spandex, videos, or power ballads. But back in 1982-with the help of the mischievous Mr. Shape-they'd drag you straight to Hell.Date Available: 10/11/2017
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subset: commoncrawl


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In Wikipedia "The Establishment" is a pejorative term to refer to the traditional ruling class elite and the structures of society which they control. The term can be used to describe specific entrenched elite structures in specific institutions, but is usually informal in application and pejorative. For example, candidates for political office are often said to have to impress the "party establishment" in order to win endorsement.
This word The Establishment you hear it more in the news now than ever, particularly in the current 2008 American Presidential Election. The people of America wants to declare their dissatisfaction with The Establishment. There is no better way to declare that in a democratic country except by election. Politicians felt it and all for change now.The American people has forced the politicians to either change or be changed. It says to the establishment we need change and we do not care if we change The Establishment or The Establishment change itself.The spirit of change is not known how and where it came from it is likely multi factorial. It is like a strong wind that blow on the faces of all of us. The establishment have to adapt to the wind and not to stand to its force. The media got it and is leading the people for call of change. We are in the perfect storm and we can not look back the change is a call by most Americans. It is not a proposal it is a strong demand.It is not an empty call or a new fad it is real new existence coming with its ideas and its strategies. It will let us all participate in a positive change in our lives. It is not only about new ideas for governing like health care and so forth but also the way in how to govern through team thinking and consensus. It is the strong wind of change that will advance our enjoyment of the advance of science and sharing wealth. It is the way of delivery it is like in health care you have all the advances and you do not have the best way of delivery.It is not about a person or a leader it is about ideas you can feel , touch and prove. It is not an empty rhetoric it is about the fine details on plans for our future. It is not about destroying The Establishment but about deep changes in the hearts and minds of the individuals of the establishment. It is about we all compete and take the lead in this new change of America ordinary Americans or members of The Establishment. It is about getting idealism out of our hearts to be our daily reality. It is about a new spirit that change all of us to a new perfect and united America.It is about we are to stand for each of us. It is about our success we see it in other people success and not their failures. It is about crossing all party lines all things that separate us to meet right in the middle and have everyone realise his dreams.It is not about me or you it is about all of us. We all are the Establishment. The elites, politicians, media, CEO's .... will get it we have let them be The Establishment and it is time to know that we are the people who established them.We are the people of America are requiring that The Establishment to feel that they are America, we and them are one and the same.


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Skip to comments.Obamacare Regulations Are 8 Times Longer Than Bible
Posted on 09/10/2013 4:09:13 AM PDT by markomalley
Since March 2010, when President Barack Obama signed the Patient Protection and Affordable Care Act (PPACA) and its companion Health Care and Education Reconciliation Act (HCERA), the administration has published in the Federal Register 109 final regulations governing how Obamacare will be implemented.
These regulations add up to 10,516 pages in the Federal Registeror more than eight times as many pages as there are in the Gutenberg Bible, which has 642 two-sided leaves or 1,286 pages.
Using the regulations.gov website and the Federal Register itself, CNSNews.com found 109 distinct regulations for the implementation of PPACA and the health-care related provisions of HCERA that had been finalized by various federal agencies and published in the Federal Register as of Sept. 9, 2013.
The Federal Register publishes documents, including proposed rules, notices, interim rules, corrections, drafts of final rules and final rules. But the CNSNews.com tabulation included only final rules for the implementation of Obamacare.
The 109 final Obamacare rules that have been published in the Federal Register so far take up 10,516 pages in the register. These pages carry an average of about 1,000 words each. So, the final Obamacare regulations published so far amount to approximately 10,516 words.
This is only an approximation, of course, because some pages in the Federal Register carry more words than others, and some regulations end in the beginning or middle of a page.
The final Obamacare rules that have been published so far range from the regulation for implementing an excise tax on tanning services, to a 546-page regulation on hospital payment systems, an 196-page regulation on electronic health records, revisions to Medicare and an 111-page regulation for the Childrens Health Insurance Programs (CHIP).
They also include the regulation for implementing the health-insurance premium subsidy that will go to American households that earn less than 400 percent of the federal poverty level and buy their insurance through government-run exchanges.
The Department of Health and Human Services filed the majority of the regulations. But other federal agencies that have filed final Obamacare regulations include the Department of Labor, the Internal Revenue Service, the Office of Personnel Management, the Food and Drug Administration, the Department of Defense, the Centers for Disease Control and Prevention, the Social Security Administration, and Veterans Affairs.
"A new religion that'll bring ya to your knees..."
The new "religion" imposed on all, to be run by the IRS
and from which THE US CONGRESS, its FAMILIES, and its
STAFF, and all Moslems are IMMUNE FREE.
Outstanding! Would you mind if I stole that line for my tagline?
And to the jug-eared moron and his Demonic Party, 10 times more important, whatever they are.
That wouldn't bother John Roberts, either.
The formula whereby we will be absolved of all our health care sins!!
The operations of the USSC are sometimes weird. A law might have fatal Constitutional problems, but if the exactly correct challenge is not brought in a particular case the USSC won't necessarily generate that challenge on behalf of one of the appellants. I think that's being lax, but as I see it, we can wail about the system we wish we had or else use the system we do to the best of our capabilities. The door for a follow up seems clear enough: bring a fresh challenge to it as a tax. There are enough constitutional misfeatures to strike it down as a tax.
How does it compare to the Koran?
I guess Alannah Myles won't care.
Nope,he's exempt (as are so many other members of the "Beautiful People").Never will he have to wait for six months for a heart operation as they currently do in Britain and Canada and as we soon will under Osama Obama Care.
And this is just Genesis, wait till we get to the Exodus.
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.


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This is the story of Francesca and Oscar, our two cats, and how I imagine they view their lives in Italy. Oscar is an Italian native, Francesca is an American transplant, and they have distinctively different personalities. But, at the end of the day, I think they would both say that Italian life is "the cat's meow".
Oscar is almost 3 1/2 years old. Born in the hills of Umbria, to a feral mother, we gave him a decidedly un-Italian name because it fit his unique, mischievous personality. But, he has decidedly Italian traits and preferences.
For starters, he communicates passionately. He just puts it all "out there", and doesn't brood. He is very direct and clear about what he wants. I've never had a cat who vocalizes with so much emotion. (Read more about cat vocalizations in this online article from Catster).
Oscar also uses his hands to communicate. For Italians, the hands are almost as important as the mouth in fully expressing oneself. Oscars stands on his hind legs and whips his paws up and down the surface of a closet, door, or a window, to let you know he expects your attention (while also expressing his displeasure that you would dare to be otherwise engaged). In the kitchen he artfully employs his little cat hands to snatch his favorite foods. Tops on his list is arugula.
Yes, arugula. His wild, greedy nature comes out whenever he sniffs the presence of arugula. It's a real head-scratcher. You would think he was eating the treat to end all other treats.
He also loves other salad greens, and he loves to nestle himself in my summer harvest of tomatoes (pomodori).
Life in most Italian households centers around the dining table and the kitchen. Oscar loves to camp out in both places. It is as though he is watching and studying to be the next Italian Master Chef. I've given up on banishing him from the kitchen. He is just too intent on being part of the action.


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Family Health Centers of Baltimore serves a large multi-cultural pediatric population of children from birth to 21 years of age.
Our pediatric staff is passionate about making sure all children have up to date vaccinations. We often partner with neighborhood schools to handle those last minute vaccine requirements. We refer our pediatric patients to our dental service, so that they learn the importance of regular dental visits, good oral hygiene, and good nutrition.
Prevention is the best medicine. Pediatric patients are seen regularly according to a periodicity schedule designed to make sure they stay compliant immunizations requirements for school. Well child appointments are part of that schedule.
Family Health Centers of Baltimore has an open door policy for sick and urgent pediatric visits. You can call for a same day appointment and be seen. If your child is contagious, they will be placed in an isolation exam room for the visit. This protects your child and others. Our department is equipped with competent staff members and state of the art equipment to provide the best care for your children.
Family Health Centers provides pediatric medicine at these convenient locations:
Hours of Operations
- Cherry Hill Office
- Monday through Friday – 8:30am – 5:00pm
- Saturday & Sunday: Closed
- Brooklyn
- Monday – Friday: 8:30AM – 5:00PM
- Saturday & Sunday: Closed
Want to Learn More About Our Fees?
Head over to our online tool that will allow you to determine how much each service at Family Health Centers of Baltimore will cost you out of pocket. All we need to know is the number of individuals in your household, and your income level.
None of the information you provide to FHCB is saved or sent anywhere, and you are given the amounts you will be responsible for immediately, right in your browser!


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More on the St. John River:
St. John River: The Good and the Bountiful
Cargo of Misery:Disease and death stalk desperate newcomers
Company Town:Boss Gibson's Marysville
Fiddleheads:Natural delicacy of the river valley
Fir Trade:Forests are vital to New Brunswick's economy
Fries to Go:Fast food for the world
Home Children:Tragic chapter in our immigration history
Big Noise:Foghorn is invented for Partridge Island
Return Flight:Bald eagles recover old nesting sites
The Sand and the Fury:The complex ecology of the Fundy tides
Starting Over:Loyalists seek refuge from revolution
Vive la République !:The unique cultural mélange of Madawaska
The Saint John River wanders through New Brunswick's best potato-growing
country. Inside a modern processing plant at Florenceville, tonnes of potatoes
are washed, peeled by steam, sliced, cooked, and frozen.
The frozen french fries are packaged and loaded into freezer trucks for delivery to restaurants
and food stores across Canada.
In 1957, two brothers, Wallace and Harrison McCain, used $100,000 of their inheritance of
the McCain family seed potato business to build their first frozen french fry plant. Today,
from its world headquarters in Florenceville, the company operates 50 processing plants on
four continents. The geographical expansion of its operations around the world has been accompanied
by a mushrooming of its product line to include vegetables, pizza, desserts, fiddleheads,
and other foods.
The company's success demonstrates how the right mix of local resources, modern technology,
and ambition can bring prosperity to entrepreneurs and their communities.
St. John River (Adobe PDF document)
of Canada (All pages in a zipped file)
top ↑


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astringent əstrĭn´jənt [key], substance that shrinks body tissues. Astringent medicines cause shrinkage of mucous membranes or exposed tissues and are often used internally to check discharge of serum or mucous secretions in sore throat, hemorrhage, diarrhea, or peptic ulcer. Externally applied astringents, which cause mild coagulation of skin proteins, dry, harden, and protect the skin. Mildly astringent solutions are used in the relief of such minor skin irritations as those resulting from superficial cuts, allergies, insect bites, or athlete's foot. Astringent preparations include silver nitrate, zinc oxide, calamine lotion, tincture of benzoin, and vegetable substances such as tannic and gallic acids, catechu, and oak bark. Some metal salts and acids have also been used as astringents.
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Use your antibodies-online credentials, if available.
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AGTRAP encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. Zusätzlich bieten wir Ihnen Angiotensin II Receptor-Associated Protein Antikörper (59) und Angiotensin II Receptor-Associated Protein Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
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A role for AT1 receptor-associated proteins in blood pressure regulation
ATRAP, a directly interacting and functionally inhibiting molecule of AT1R (zeige AGTR1 ELISA Kits), plays a protective role against the development of systemic insulin (zeige INS ELISA Kits) resistance via regulatory effects on adipose tissue function.
The phosphatidylinositol transfer protein RdgBbeta (zeige PITPNC1 ELISA Kits) binds 14-3-3 (zeige YWHAQ ELISA Kits) via its unstructured C-terminus, whereas its lipid-binding domain interacts with the integral membrane protein ATRAP (angiotensin II type I receptor-associated protein).
the GG genotype of the AGTRAP rs11121816 T/G single nucleotide polymorphism was associated with increased mortality in two cohorts of patients who had septic shock.
CSF (zeige CSF2 ELISA Kits) angiotensin II, ACE (zeige ACE ELISA Kits), and ACE2 (zeige ACE2 ELISA Kits) levels are decreased in neuromyelitis optica/NMO spectrum disorder patients with anti-AQP4 (zeige AQP4 ELISA Kits) antibody, reflecting severe destruction of perivascular astrocytes
Small interfering RNA significantly attenuates angiotensin II type 1 receptor (zeige AGTR1 ELISA Kits)-stimulated inositol phosphate formation.
cloned a new human gene cDNA that codes for a homolog of the murine Agtrap protein
isolation of a novel protein, ARAP1, which promotes recycling of angiotensin(1A) to the plasma membrane in HEK (zeige EPHA3 ELISA Kits)-293 cells
CAML (zeige CAMLG ELISA Kits) is an important signal transducer for the actions of Ang II (zeige AGT ELISA Kits) in regulating the calcineurin-NFAT (zeige NFATC1 ELISA Kits) pathway and the interaction of CAML (zeige CAMLG ELISA Kits) with ATRAP may mediate the Ang II (zeige AGT ELISA Kits) actions in vascular physiology
verexpression of ATRAP induced adiponectin expression both in adipose tissue and primary adipocyte. Our data revealed that adipose ATRAP plays an important role in preventing metabolic disorders and adiponectin possibly mediates the effects of adipose ATRAP.
ATRAP plays an important role in inhibiting kidney aging, possibly through sirtuin1 (zeige SIRT1 ELISA Kits)-mediated mechanism independent of blocking AT1R signaling, and further protecting normal life span.
Results presented in this study suggested that the enhancement in adipose ATRAP plays a protective role against the development of diet-induced visceral obesity and insulin (zeige INS ELISA Kits) resistance through improvement of adipose inflammation and function via the suppression of overactivation of adipose AT1R signaling.
Renal ATRAP downregulation is involved in the onset and progression of blood pressure elevation caused by renal mass reduction, and implicates ATRAP as a therapeutic target for hypertension in chronic kidney disease.
These results implied that AngII could effectively induce EpiCs to differentiate into vascular smooth muscle-like cells through the AT1 receptor.
ATRAP expression in brown adipose tissue does not influence the pathogenesis of dietary obesity or metabolic disorders.
Identify Atrap as a novel regulatory protein (zeige TGFB1 ELISA Kits) of the cardiac Ca(2+)-ATPase SERCA2a (zeige CA-P60A ELISA Kits). Suggest that Atrap enhances the activity of SERCA2a (zeige ATP2A2 ELISA Kits) and, consequently, facilitates ventricular relaxation.
These results suggest that increased formation of AT1R-P2Y6R heterodimers with age may increase the likelihood of hypertension induced by Ang II (zeige AGT ELISA Kits).
although erythropoiesis and blood pressure are negatively controlled through the AT1 receptor inhibition in vivo, the pathways involved are complex and distinct
Distal tubule-dominant enhancement of ATRAP inhibits pathological renal sodium reabsorption and blood pressure elevation in response to high salt loading.
This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms.
angiotensin II receptor-associated protein
, type-1 angiotensin II receptor-associated protein
, Type-1 angiotensin II receptor-associated protein
, AT1 receptor-associated protein
, ATI receptor-associated protein
, angiotensin II, type I receptor-associated protein
, AT1 receptor
, angiotensin II receptor, type I


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What is a Child Life Specialist?
Child life specialists typically work in a health care setting providing support to children and families during their admission. The hospital can be overwhelming and scary. Child life specialists provide a sense of normalcy through play, creative expression and education. They follow a family centered care approach in their interactions with the pediatric patient as well as siblings, parents, caregivers and children of adult patients.
Specialists prepare patients for medical procedures through play, teaching dolls, visuals and using developmentally appropriate language. They also offer procedural support and teach coping strategies to help empower children and families through their experience.
Hospitals have a variety of departments that may provide a specialist. They are typically found in the inpatient units, emergency department, day surgery, pediatric intensive care unit, out-patient, psych unit and more.
To learn more about Child Life go to the website http://www.childlife.org


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Saturday, 22 January 2011
Hatching Ideas
4 comments:
- Kim said...
I awarded you the Stylish Blogger Award, Leigh! Take a look at my blog and it will tell you what to do. Write 7 things about yourself, award 7 other stylish bloggers and let them know. You probably know the whole schepeel (don't think I spelled that right) Anyway I am excited you are excited to move and redecorated again. Can't wait to see the pics! I love these pictures you posted today! Good luck. Talk at ya soon!xxxooo
- 22 January 2011 at 23:15
- melissa-jade gregan said...
ooooh. jealous. that is a beautiful colour. its so fresh, love it. happy moving.
- 23 January 2011 at 12:52
- alexxis young said...
can you please tell me where you found/bought this gold bed!? I am in love with it and would love to have it as my own
- 8 September 2013 at 02:53
- Leigh said...
Hi Alexxis,
All of these photos I found on Pinterest so I'm not totally sure where the bed is from! Sorry about that.
- 20 September 2013 at 19:44


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Welcome to the Baskets in the Park's website.
We invite you to express your sentiments and celebrate your special moments with a bounty of gift baskets designed to pamper, congratulate and bring joy.
Whether sending a gift to a special someone in Edmonton, throughout Alberta or across Canada, we will be happy to arrange delivery. Or, drop by and visit our gift shop. Awaiting you is an enjoyable shopping experience in a tranquil environment with unique and precious gift items to choose from.


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Reports and Campaigns
Workplace and TU campaigns keywords:
Reports and campaigns:
Stop the slaughter of Tamils (7)
Workplace and TU campaigns (17492)
Related websites
Trade Unionist and Socialist Coalition
National Shop Stewards Network
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Search site for keywords: Mental health - Unions - Health - Bullying - Jobs
300,000 a year forced to leave work
Unions must fight workplace mental health crisis
Jac McAllister-Green, Northampton Socialist Party
Workers with mental health problems are leaving their workplaces at a rate of up to 300,000 a year.
For those of us who have suffered with poor mental health, the findings of the government's 'Thriving at Work' report are unsurprising.
Work is becoming more stressful. The financial uncertainty and instability of poverty pay, zero-hour or other insecure contracts, and bullying management is becoming more apparent.
Too many of us cannot cope with conditions in our workplaces. We are effectively forced into leaving jobs, finding ourselves at the mercy of a punishing 'welfare' system.
I have experienced this first-hand in more than one previous workplace. I can state with conviction it has a deleterious effect on your confidence. It makes you question your ability to do the job.
I was subject to workplace bullying in a public sector role. I was forced to explain bouts of absence to my colleagues - the presumption being my mental health issues were insignificant.
At the time, I was homeless, having been made redundant from another public sector job and unable to keep up with increasing living costs. I was sofa-surfing at friends' houses for a number of months.
My story is by no means unique. This is an all too common occurrence in austerity Britain. After five months, I was out of work once more.
6% of people with long-term mental health conditions move from employment to unemployment each quarter. For long-term physical conditions it's 3.5%.
On top of the huge human cost, the report attributes an economic cost of up to £99 billion a year to failure to support those with mental health problems.
The Socialist Party fights for full funding for the NHS, including massive expansion of mental health facilities, and an end to bullying and insecure work. There can be no doubt the rapid deterioration of morale in workplaces across the country is due to the draconian policies of the Tories and Blairites.
Increasingly, people have to work multiple jobs to make ends meet. Sometimes even that is not enough to cope with rising living costs. Claimants of in-work benefits are also on the rise. It is simply unacceptable that we are forced into this situation.
The Socialist Party campaigns within trade unions for effective action against poor pay and conditions, and for coordinated strikes to bring down this bosses' government.
The situation will only improve with a leadership willing to bring workers together to fight, demanding decent conditions and the right to real support at work.
- Socialism 2017 (11 and 12 November, central London)
Discussions include: mental health and young people - how would socialism be different?
Find out more and book tickets at socialism2017.net
12 Dec France in revolt
19 Dec Salford Socialist Party: Blacklisting
5 Jan Socialist Party national women's meeting
6 Jan Socialist Party national LGBT+ meeting
Phone our national office on 020 8988 8777
Email: email@example.com
Locate your nearest Socialist Party branch Text your name and postcode to 07761 818 206
Regional Socialist Party organisers:
Eastern: 0798 202 1969
East Mids: 0773 797 8057
London: 020 8988 8786
North East: 0784 114 4890
North West 07769 611 320
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On July 29th, report on interim summary for 973 Program (Earthquake disaster mechanism and aseismic design theory for underground rock engineering in intensive seismic area) was held in Beijing successfully. This conference aims to check each task completion, adjust and optimize the project settings, funds and personnel allocation, further defined the future study of each project plan and goal.
MOST directors, academician MA Hongqi, academician BAI Yilong, project experts group academician QIAN Qihu, academician ZHENG Shouren, academician ZHONG Denghua, academician DU Xiuli, researcher LI Haibo, researcher LI Xiaojun, etc. Relevant Directors which from MOST Basic Research Management Center, Bureau of Frontier Sciences & Education, Science and Technology Department of Hubei Province, and other project team members attend the meeting.
In the meeting, the Chief Scientist reseacher SHENG Qian introduces the overall implementation of the project and phased research results. Person in charge of each project reports each task's completion status, outstanding progress, and the follow-up work plan.
On the basis of reviewing and listening the summary report of project, experts discuss and appraise the project status and research prospect. They affirm the interim results of each project, give valuable comments and suggestion. After the evaluation of experts, expert group members agree that the key scientific problems is clear, project setting is reasonable, work status is great, and successfully complete the preliminary work tasks, part of the work has innovative breakthroughs, shows great research prospect. It lays a good foundation for next three year research work.


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I have been in love with Tilda fabrics for several years, and so disappointed it's not for sale in the U.S. So my lovely sister in Japan bought this charm pack for me, and even though I'm afraid to use it (because what if my project doesn't work?), I'm going to jump in and just do it.
I doodled up a pattern.
I'm going to use the shorter version of the tulip. I wanted a pattern that doesn't cut down the charm squares very much, so much of the fabric pattern is left whole.
And now I find out Tilda fabric is making its way into the U.S. market! So I ordered a yard in two colors. I'm hoping the "ginger" color will match the orange above. I'll know for sure in a couple days.
I can't wait to get sewing!
Tilda fabrics found here: http://www.intrepidthread.com
and here: https://www.shabbyfabrics.com/Tilda


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Standard Disclaimers: Please set appropriate followups. Recommendation does not factor in price. Not all books will have arrived in your area this week. Last week of the regular semester! Rants, Capsules can be found on my homepage, http://www.eyrie.org/~dvandom/Rants First Look Comments: Books I read over the weekend as First Looks, but didn't buy, so can't really say much in detail about. DC has stopped having First Looks, so it's just Marvel and Image...and there's word that Diamond doesn't want to bother with the program at all anymore. Books for next week - Nova #9: Marvel - Apparently, dogs love armpitting. The two part side story ends decently, and I like Cosmo. $2.99/$3.05Cn New Warriors #6: Marvel - And the first arc wraps up with revelations. Some petty, some major, some clearly faked. There's a certain amount of rah-rah involved too, but I can cope. Recommended. $2.99/$3.05Cn Fantastic Four #552: Marvel - The cliffhanger is resolved, there's a little talking, then lots of fight scene and oration. Plus some Valid Points. Recommended. $2.99/$3.05Cn Capsules: Short, relatively spoiler-free reviews of books I actually bring home (as opposed to reading in preview form in the shop or online). If I get a book late due to distributor foulups or whatever, I'll put it in the Missing section. Books of Note (Strongly Recommended or otherwise worthy): PS238 #28, Atomic Robo #3 (of 6) "Who Da Ubermensch?": Dark Horse Presents - Normally, I don't review web-only content, because that's a slippery slope into trying to review the bazillion webcomics out there. But once in a while I'll make an exception, and http://myspace.com/darkhorsepresents?issuenum=5&storynum=3 is one of those exceptions. It's flash-based, which is something of a nuisance (i.e. non-trivial to make an offline copy, but I'm sure such either exist already or will by the end of the day). This is a full-color Empowered story by Adam Warren, which is WHY I'm making the exception. :) Most of it is introduction and recap, aiming this at people who haven't read Emp yet but who hopefully will soon. But there's a tiny bit of actual story in this 8 page story, and some cleverness on Emp's part. However, she also manages to end up in her usual fate anyway. And that's the part that's there for the existing readers, I think. Heh. Recommended. Free online. Ninja High School #155: Antarctic Press - The cover homages "The Lady and the Tramp," although I'd argue it's not clear which NHS character fills which Disney role. (rimshot) Anyway, this brings the "last kitsune" subplot to a head, with the Rumplestiltskin and Yuudai storylines simmering on the back burner. Oh, and I'd be remiss as a geek if I didn't point out that while the splash page is "after Escher," it's not quite a copy of Relativity, even allowing for rotation. :) Recommended. $2.99/$2.99Cn (woot, parity!) The Twelve #0: Marvel - One of two "dredge up unrevamped 1940s characters" projects out this month. This zero issue reprints stories with Rockman, Laughing Mask and the Phantom Reporter, then shows the updated designs for the whole team and the same preview pages that appeared in Previews. An interesting look at the lesser lights of the Golden Age. And I'm amused that the Phantom Reporter has two secret identities: millionaire playboy and cub reporter. So, not only was he ripping off both Batman and Superman, he was also a sort of proto-Moon Knight. :) Recommended. $2.99/$3.05Cn Ms. Marvel #22: Marvel - Aaron is only in this for one page, but he steals the show as usual. The main story is head-trippy but not as compelling as Reed probably hoped. Mildly recommended. $2.99/$3.05Cn Howard the Duck #3 (of 4): Marvel - She-Hulk is on the cover, but Bobillo doesn't draw her like he did when he was her regular artist, oddly. She looks like his usual inside, though. Continuity-wise there's some issues here, but not really worth getting tied in knots about. And while Templeton has some amusing core ideas here and the occasional clever moment, he belabors some of his points and drains them of the funny. Mildly recommended. $2.99/$3.05Cn Avengers the Initiative Annual #1: Marvel - Part of the "Secret Invasion" event, which I'll admit fills me with a sense of dread and foreboding. But, um, not the one I think Marvel Editorial wants me to feel. Gage joins Slott on the writing. Rather than a single big story, this Annual is a collection of origin stories and foreshadowing, setting up at least three future threats, two of which I'd guess are part of the Secret Invasion thing, and the third confined to Initiative. A decent read. Recommended. $3.99/$4.05Cn Justice Society of America #11: DC - Eh, this issue sort of meanders around, eventually getting to the point but...it doesn't even really feel like padding or decompression, just a serious lack of focus. The obligatory fight scene was decent, but didn't really seem to serve the plot in any particular way. It could have been any fight scene and done the same. Starman addressing the reader was cute, though. Mildly recommended. $2.99/$3.65Cn Justice League of America #15: DC - Man, I am getting so tired of Benes. His art is just so stereotypically "Imitation Image Founder". Oh, and someone neglected to tell the editor that Giganta isn't wearing the leopard print dress anymore (see recent issues of Blue Beetle), or he decided he wanted the panties gag more than he wanted it to fit with current portrayal of the character. The issue is otherwise a big brawl of the "kitchen sink" variety, with no particular direction or theme. Some good bits, but a feeling that McDuffie was just tossing in everything that came to mind. Mildly recommended. $2.99/$3.65Cn Dynamo5 #9: Image - Not much to say, a bunch of little stuff moves forward, one of the five finds a new power, and we see a new threat start to assemble (well, probably a few new threats, all things considered). No "big wow" moments, but solid storytelling. The pinup of Scrap is perhaps a bit more suggestive than the artist intended (or the artist was trying to see how much he could get away with). Recommended. $2.99 (Image gives up on a separate Canadian price now, I see) Invincible #47: Image - Lots of subplot-servicing here too. And while it continues to be mainly about "what happens between the fight scenes" for the heroes, we also get some time on the home life of the villains as well, for a nice change of pace. Recommended. $2.99 (Aside: I notice now from the back cover ad that the TPB of the Official Handbook of the Invincible Universe contains content not found in the two issue series...24 PAGES more material, d'oh. And my store didn't order any for the shelf. Since Diamond lately sucks at sending out anything I try to backorder, it's a good thing deepdiscount.com lists it.) PS238 #28: Do Gooder Press - Ah, a caper! Well, a mask-and-caper. Moose! Sorry, I'm being cryptically weird, but that's gonna happen when reading this book. Strongly recommended. $2.99 Atomic Robo #3 (of 6): Red5 Comics - By page 9, I had found and replaced six "end of post quotes", if not more. I think my number two choice nicely sums up the issue, though: "Judging by how these things usually go, I think it's safer to ASSUME mummies until proven otherwise." "That's just good advice in ANY line of work." Very strongly recommended. $2.95 Gone Missing: Stuff that came out some places this week and that I wanted to buy, but couldn't find for whatever reason, so people don't have to email me asking "Why didn't you review X?" (If it's neither here nor in the section above, though, feel free to ask, I might have forgotten about it!) Current list as of 12/5: Still missing and might come in: Fallen Angel #15, Doktor Sleepless #2, PS238 #25, Transformers Beast Wars Sourcebook #1 (all of these have been covered in my CBR Special), Sky Sharks #2, Gamma Files, Official Handbook to the Gold Digger Universe #11. Awards: "At Least She's Not In Violation Of Seatbelt Laws" Award to "Who Da Ubermensch?" "High-Tech Etchings" Award to Ninja High School #155 "I Think The Heroes Killed More People Than The Villains Did" Award to The Twelve #0 "There But For The Grace Of...Wait, I Went There After All" Award to Ms. Marvel #22 "This Looks Like A Job For...Keith Olbermann!" Award to Howard the Duck #3 (of 4) "Guess Southpaw's Not Involved After All" Award to Avengers the Initiative Annual #1 "Most Disguisting Explode-Self Power Ever" Award to Justice Society of America #11 "E.F. Hutton Has Nothing On The Bat" Award to Justice League of America #15 "Intellectual Real Estate" Award to Dynamo5 #9 "Epic Fail" Award to Invincible #47 "Attack Of The Servo-Bots" Award to PS238 #28 "Sorry, Egypt, All Streaks Gotta End Sometime" Award to Atomic Robo #3 (of 6) Dave Van Domelen, "I didn't found this crazy organization to NOT nuke things." - Atomic RoboBack to the Main Rants Page.
Or shovel your way back to the December 2007 Page.


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People, we've got ourselves a steal. There's a Humble Bundle at this time that provides the whole Company of Heroes franchise just for $10. Yes, only for 10 dollars you could have everything. Why? Why drop this out now? Well, Company of Heroes had switched ten years old this season.
Humble Bundle mentioned that the cost for those these games can skyrocket up to $218. But due to the Humble Bundle platform, you may choose what you'll get beginning from only a dollar and you can go more too.
FOR $1 Or Even More
For $1 or even more, you are able to acquire the very first Company of Heroes, Company of Heroes: Opposing Fronts, Company of Heroes: Tales of Valor and Company of Heroes 2 – The Western Front Military: Oberkommando West.
PAY Greater Than The Typical: $7.25
Should you pay greater than the typical of $7.25, you'll unlock Company of Heroes 2 – The Western Front Military: US Forces, Company of Heroes 2, Company of Heroes 2 – Situation Blue Mission Pack, Company of Heroes 2 – Southern Fronts Mission Pack, Company of Heroes 2 – Victory at Stalingrad Mission Pack and the organization of Heroes 2 soundtrack.
PAY $10 Or Even More
Having to pay $10 or even more would afford you the organization of Heroes 2 – The British Forces, Company of Heroes 2 – Ardennes Assault, Company of Heroes 2 – Ardennes Assault: Fox Company Rangers, Company of Heroes 2 – Exclusive Skin Pack along with a Company of Heroes Art Book.
PAY $30 Or Even More
For those who have it in your soul to pay for $30 or even more, you're going to get everything in the above list along with a awesome Exclusive Company of Heroes Bundle T-Shirt. Seems like a steal right? It's. But it's furthermore a great cause or try causes.
Charitable organization
The awesome factor about Humble Bundle is it can help you lead to non profit organizations too. You may choose where your hard earned money goes. You are able to spread it with the developer, SpecialEffect, Whale and Dolphin Conservation, Water Aide, Code Club or even a fifth charitable organization. You may choose it via Paypal Giving Fund.


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Christmas is coming and so is the SNOW!!! We are suppose to get 6 - 12 inches. My fingers are crossed for a snow day!
I got some recent requests for some gluten free recipes, so I am going to post a few!
There is also a restaurant/store in manchester that specializes in Gluten Free foods.
I have never been here, but I heard it was really good: http://www.heavenlyfoddermeals.com/
These recipes are all Gluten free:
Thai lettuce wraps with Spicy Sweet and Sour Sauce
3 ounces of thick rice noodles (rice vermicelli)
4 ounces large raw shrimp (peeled & deveined)
1 medium cucumber, peeled, seeded and cut into matchstick pieces
1/2 cup of fresh cilantro leaves (I use parsley for a substitute, because I dislike cilantro)
1/2 cut fresh mint leaves
1 large bunch green leaf lettuce or boston lettuce
Soak noodles in hot water for 10 mins. to soften. Rinse under cold running waer to cool & drain.
Boil shrimp (you can buy them already cooked to skip this step) Otherwise cook 3 - 5 minutes untim pink.
Cut the shrimp lengthwise in half.
Arrange shrimp, noodles, cucumber cilantro, and mint in the center of lettuce leaves and roll up.
Spicy Sweet and Sour Sauce
1 green onion (otherwise called a scallion)
2 TBS rice vinegar
1 TBS cornstarch
3/4 cup water
1/4 cup brown sugar
1/2 tsp red pepper flakes
Mince green onion, reserve some green parts for garnish.
Combine with vinegar and cornstarch in small bowl. Mix well.
Combine water, brown sugar, pepper and minced green onion in small saucepan, bring to boil.
Stir in cornstarch mix. Return to boil. Cook 1 minute until sauce thickens.
Serve and dip your Thai lettuce wraps!
Beef Enchiladas
6 ounces of lean ground beef
1tsp minced garlic
1/4 cup green onions - sliced
1 cup mexican cheese
3/4 cup chopped tomatos
1/2 cup corn
1/2 cup black beans
1/3 cup cooked white or brown rice
1/4 cup salsa
6 (6inch) corn tortillas
1/2 cup enchilada sauce (McCormick makes a gluten free sauce I believe)
1/2 cup sliced romain lettuce
Preheat oven to 375 F, brown ground meat, drain and discard fat, add green onions and garlic. Cook about 2 minutes
Combine meat mix with 3/4 cup cheese, 1/2 cup tomato, corn, beans, rice and salsa. Mix well and spoon down center of tortillas. Roll up.
In casserole dish place enchiladas seam side down. Spoon Enchilada sauce on top. Cover and bake for 15 minutes.
Remove from oven and sprinkle with remaining 1/4 cup cheese, then bake for an additional 10 minutes. Serve with remaining lettuce, tomatos, salsa and sour cream.
There are many blogs out there that are Gluten Free Recipe Blogs, I have found some wonderful recipes on them and I hope they will be helpful for those looking for a Gluten Free diet!
Enjoy the cold weather, be safe in the snow!!! Don't Drive if you dont have to!
<3 Laura


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A new genome-wide association study and meta-analysis of approximately 7,000 bladder cancer cases and 12,000 controls of European descent identified two new loci that achieved genome-wide statistical significance (rs10936599 on 3q26.2 and rs907611 on 11p15.5) as well as two additional loci that approached genome-wide statistical significance (rs6104690 on 20p12.2 and rs4510656 on 6p22.3). (Figueroa JD, Ye Y, Siddiq A, et al. Genome-wide association study identifies multiple loci associated with bladder cancer risk. Hum Mol Genet 2014;23:1387–1398)
The authors found an association between a representative genetic variant (rs10775480) of SLC14A1, a gene linked to bladder cancer in genome-wide association studies, and urine concentration, as measured by urinary specific gravity, among 275 population-based controls enrolled in the New England Bladder Cancer Study, suggesting a possible mechanism for the increased bladder cancer susceptibility associated with rs10775480. (Koutros S, Baris D, Fischer A, et al. Differential urinary specific gravity as a molecular phenotype of the bladder cancer genetic association in the urea transporter gene, SLC14A1. Int J Cancer 2013;133:3008–3013)
This large international collaborative study provided the first strong evidence that breast cancer risks associated with several single nucleotide polymorphisms were modified by established risk factors (age at menarche, parity, breastfeeding, body mass index, height, oral contraceptive use, menopausal hormone therapy use, alcohol consumption, cigarette smoking, and physical activity). (Nickels S, Truong T, Hein R, et al. Evidence of gene-environment interactions between common breast cancer susceptibility loci and established environmental risk factors. PLoS Genet 2013;9(3):e1003284.)
Through the Consortium of Investigators of Modifiers of BRCA1/2, the investigators identified stronger associations with breast cancer risk among BRCA2 mutation carriers for genetic variants in FGFR2, MAP3K1, CDKN2A/B, and PTHLH than previously reported and identified a novel susceptibility allele at 6p24 (rs9348512) that was inversely associated with risk. The locus lies within a region containing TFAP2A, which encodes a transcriptional activation protein that interacts with several tumor suppressor genes. (Gaudet MM, Kuchenbaecker KB, Vijai J, et al. Identification of a BRCA2-specific modifier locus at 6p24 related to breast cancer risk. PLoS Genet 2013;9(3):e1003173)
A multi-stage genome-wide association study (GWAS) of 11,705 BRCA1 carriers (of whom 5,920 were diagnosed with breast cancer and 1,839 were diagnosed with ovarian cancer), with a further replication in an additional sample of 2,646 BRCA1 carriers, identified a novel breast cancer risk modifier locus at 1q32 for BRCA1 carriers (rs2290854) and two novel ovarian cancer risk modifier loci at 17q21.31 (rs17631303) and 4q32.3 (rs4691139). (Couch FJ, Wang X, McGuffog L, et al. Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk. PLoS Genet 2013;9:e1003212)
Different associations with body mass index, age at first birth, and education level between inflammatory breast cancer cases and other types of breast cancer suggest a distinct etiology for inflammatory breast cancer. (Schairer C, Li Y, Frawley P, et al. Risk factors for inflammatory breast cancer and other invasive breast cancers. J Natl Cancer Inst 2013;105:1373–1384)
By using methods accounting for gene-environment interaction, the investigators identified novel genetic loci associated with breast cancer risk, including rs10483028 and rs2242714 on chromosome 21 and rs12197388 in ARID1B on chromosome 6. (Schoeps A, Rudolph A, Seibold P, et al. Identification of new genetic susceptibility loci for breast cancer through consideration of gene-environment interactions. Genet Epidemiol 2014;38:84–93)
A study of the associations between variants of human papillomavirus (HPV) 16 and risk of cervical neoplasia among women in Taiwan showed that the Asian variant was the most prevalent variant (81.8%) of HPV 16 in Taiwan and also was associated with a 10-fold increased prevalence of histologically confirmed cervical intraepithelial neoplasia grade 3 or worse, compared to the HPV 16 European variant. (Chang YJ, Chen HC, Pan MH, et al. Intratypic variants of human papillomavirus type 16 and risk of cervical neoplasia in Taiwan. J Med Virol 2013;85:1567–1576)
In a case-control study within the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial, a single nucleotide polymorphism at rs2838732 (ITGB2) was associated with colorectal neoplasia, with a stronger association for colorectal cancer than for adenoma, and among never and former smokers but not among current smokers. (Chang CM, Chia VM, Gunter MJ, et al. Innate immunity gene polymorphisms and the risk of colorectal neoplasia. Carcinogenesis 2013;34:2512–2520)
Long-term smoking and ingestion of opium, even in low doses, was associated with increased risk of death from both malignant and nonmalignant digestive diseases among the participants of the Golestan Cohort Study, a prospective cohort study in northeastern Iran. (Malekzadeh MM, Khademi H, Pourshams A, et al. Opium use and risk of mortality from digestive diseases: A prospective cohort study. Am J Gastroenterol 2013;108:1757–1765)
A genome-wide association study (GWAS) compared 2,390 cases of esophageal adenocarcinoma and 3,175 cases of Barrett esophagus with 10,120 controls in 2 phases and identified novel associations of loci at 19p13 (rs10419226) in CRTC1, 9q22 (rs11789015), and 3p14 (rs2687201). The study also extended the previously reported association of a loci near the putative tumor suppressor gene FOXF1 at 16q24 with Barrett esophagus to now include esophageal adenocarcinoma. (Levine DM, Ek WE, Zhang R, et al. A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus. Nat Genet 2013;45:1487–1493)
A case-cohort study in China showed that higher circulating vitamin C levels were associated with a reduced risk of incident gastric adenocarcinoma, but no association was found with esophageal squamous cell carcinoma. (Lam TK, Freedman ND, Fan JH, et al. Prediagnostic plasma vitamin C and risk of gastric adenocarcinoma and esophageal squamous cell carcinoma in a Chinese population. Am J Clin Nutr 2013;98:1289–1297)
An examination of 554 single nucleotide polymorphisms in 53 Fas signaling-related genes using a pathway-based approach identified significant associations for gastric cancer overall and gastric cardia adenocarcinoma, but not gastric noncardia adenocarcinoma, among ethnic Chinese. Among examined genes in the Fas signaling pathway, MAP2K4, FAF1, MAPK8, CASP10, CASP8, CFLAR, MAP2K1, CAP8AP2, PAK2, and IKBKB were associated with risk of gastric cancer, and FAF1 and MAPK8 were significantly associated with risk of both gastric cardia adenocarcinoma and gastric noncardia adenocarcinoma. (Hyland PL, Lin SW, Hu N, et al. Genetic variants in fas signaling pathway genes and risk of gastric cancer. Int J Cancer 2014;134:822–831)
(See under Esophageal Cancer)
In an international collaborative study of 2,648 gastric cancer patients, a stronger association for smoking, but not for alcohol consumption, was observed among patients with Epstein-Barr virus (EBV)-positive tumors than among patients with EBV-negative tumors. (Camargo MC, Koriyama C, Matsuo K, et al. Case-case comparison of smoking and alcohol risk associations with Epstein-Barr virus-positive gastric cancer. Int J Cancer 2014;134:948–953)
In a cohort study of a low vitamin D population in China, higher baseline serum 25(OH) vitamin D concentrations were associated with significantly lower risk of chronic liver disease deaths, and among those with higher serum calcium, incident liver cancer. (Wang JB, Abnet CC, Chen W, et al. Association between serum 25(OH) vitamin D, incident liver cancer and chronic liver disease mortality in the Linxian Nutrition Intervention Trials: A nested case-control study. Br J Cancer 2013;109:1997–2004)
In a study of lung cancer among never smokers from a region in China where coal is typically burned indoors, high mutation frequencies in EGFR exon 18 and KRAS and low mutation frequency in EGFR exon 21 were observed that were strikingly divergent from mutation patterns found in other smoking and never smoking populations from Asia. (Hosgood HD 3rd, Pao W, Rothman N, et al. Driver mutations among never smoking female lung cancer tissues in China identify unique EGFR and KRAS mutation pattern associated with household coal burning. Respir Med 2013;107:1755–1762)
Data from 12 case-control studies in the InterLymph Consortium demonstrated an increased risk of Hodgkin lymphoma among ever smokers overall (odds ratio [OR] = 1.1), which reflected associations with mixed cellularity subtype (OR = 1.6) and Epstein-Barr virus–positive tumors (OR = 1.8) among current smokers. (Kamper-Jørgensen M, Rostgaard K, Glaser SL, et al. Cigarette smoking and risk of Hodgkin lymphoma and its subtypes: A pooled analysis from the International Lymphoma Epidemiology Consortium (InterLymph). Ann Oncol 2013;24:2245–2255)
In a population-based case-control study among Connecticut women, investigators identified three single nucleotide polymorphisms in STAT3 (rs12949918 and rs6503695) and STAT4 (rs932169) associated with non-Hodgkin lymphoma risk, suggesting that genetic variation in JAK/STAT pathway genes may play a role in lymphomagenesis. (Chen Y, Lan Q, Zheng T, et al. Polymorphisms in JAK/STAT signaling pathway genes and risk of non-Hodgkin lymphoma. Leuk Res 2013;37:1120–1124)
A pooled analysis of four international case-control studies of non-Hodgkin lymphoma (NHL) observed that prolonged high-intensity occupational exposure to trichloroethylene conveys an increased risk of NHL, particularly for follicular lymphoma and chronic lymphocytic leukemia, but not diffuse large B cell lymphoma. (Cocco P, Vermeulen R, Flore V, et al. Occupational exposure to trichloroethylene and risk of non-Hodgkin lymphoma and its major subtypes: A pooled InterLymph analysis. Occup Environ Med 2013;70:795–802)
A population-based case-control study of non-Hodgkin lymphoma (NHL) among Connecticut women observed significantly reduced risks for the CBS Ex9+33C > T (TT vs. CC), the MBD2 −2176C > T (CC vs. TT), and the FTHFD Ex21+31A > G (AG vs. AA) genotypes, with the reduced risk mainly apparent among those who had higher dietary intakes of vitamin B6, methionine, and folate, suggesting that variation in several one-carbon metabolizing pathway genes may influence the risk of NHL through gene-nutrient interactions involving dietary nutrient intakes. (Li Q, Lan Q, Zhang Y, et al. Role of one-carbon metabolizing pathway genes and gene-nutrient interaction in the risk of non-Hodgkin lymphoma. Cancer Causes Control 2013;24:1875–1884)
After genetic regions have been identified in genome-wide association studies, investigators often follow up with more targeted investigations of specific regions. These investigations typically are based on single nucleotide polymorphisms (SNPs) with dense coverage of a region. Methods are thus needed to test the hypothesis of any association in given genetic regions, combining p-values obtained from testing individual SNPs. The authors have devised a permutation-based version of a sequential procedure for testing the global null hypothesis of no association in a region that accounts for correlations of tests based on SNPs in the same genetic region. (Chen HS, Pfeiffer RM, Zhang S. A powerful method for combining P-values in genomic studies. Genet Epidemiol 2013;37:814–819)
The authors assessed the variability of a large subset of metabolites among 60 women at baseline and year one of the Shanghai Physical Activity Study, and observed patterns were confirmed in the Prostate, Lung, Colorectal and Ovarian Cancer Screening study. The authors offer guidelines for determining the sample sizes needed to conduct metabolomic studies in epidemiology. (Sampson JN, Boca SM, Shu XO, et al. Metabolomics in epidemiology: Sources of variability in metabolite measurements and implications. Cancer Epidemiol Biomarkers Prev 2013;22:631–640)
The authors studied various aspects of building risk prediction models based on single nucleotide polymorphisms (SNPs) from genome-wide association studies (GWAS) to improve discriminatory accuracy, as measured by the area under the receiver operating characteristic curve, using realistic estimates of the distributions of genetic effect sizes, allele frequencies, and linkage disequilibrium patterns based on GWAS data for Crohn's disease and prostate cancer. The most critical aspect of prediction model building was initial SNP selection, with a single-phase procedure and univariate (marginal) estimation performing best. For complex diseases and samples of 10,000 or fewer cases and controls, one should limit the number of SNPs to tens or hundreds. (Wu J, Pfeiffer RM, Gail MH. Strategies for developing prediction models from genome-wide association studies. Genet Epidemiol 2013;37:768–777)
As a replacement for the Bonferroni correction, the authors propose a permutation approach that tests multiple putative mediators and controls the familywise error rate, which significantly improves the power to detect mediators even when all biomarkers are independent. (Boca SM, Sinha R, Cross AJ, et al. Testing multiple biological mediators simultaneously. Bioinformatics 2014;30:214–220)
An analysis of six case-control studies participating in the International Multiple Myeloma Consortium (1,567 cases, 7,296 controls) observed a significantly decreased risk associated with ever drinking alcohol (men: odds ratio [OR] = 0.7; women: OR = 0.8), with a stronger inverse association when comparing current to never drinkers (men: OR = 0.6; women: OR = 0.6), but null among former drinkers. (Andreotti G, Birmann B, De Roos AJ, et al. A pooled analysis of alcohol consumption and risk of multiple myeloma in the International Multiple Myeloma Consortium. Cancer Epidemiol Biomarkers Prev 2013;22:1620–1627)
In a prospective cohort of 83,377 U.S. men and women aged 51–72 years, the authors observed that participants who reported less than 5 hours of sleep per night had an approximately 40% higher risk of developing obesity than those who reported 7–8 hours of sleep. (Xiao Q, Arem H, Moore SC, et al. A large prospective investigation of sleep duration, weight change, and obesity in the NIH-AARP Diet and Health Study cohort. Am J Epidemiol 2013;178:1600–1610)
Among men residing in Brazil, Mexico, and the United States who were HIV-negative and participants in the Human Papillomavirus (HPV) Infection in Men cohort study, newly acquired oral oncogenic HPV infections were rare and most were cleared within one year. Acquisition of oral oncogenic HPV was significantly associated with smoking and not being married or cohabiting, but was similar across countries, age groups, and reported sexual behaviors. (Kreimer AR, Pierce Campbell CM, Lin HY, et al. Incidence and clearance of oral human papillomavirus infection in men: The HIM cohort study. Lancet 2013;382:877–887)
(See under Breast Cancer)
In a retrospective cohort of 9,825 women evaluated for infertility at five clinical sites in the United States between 1965 and 1988 with follow-up through 2010, there was no association of ovarian cancer risk with ever use of clomiphene citrate (CC) or gonadotropins, and no evidence was found that any of several more detailed subgroups of usage were related to an increased risk with one exception: women who used CC and remained nulligravid did demonstrate much higher risks than those who successfully conceived compared with nonusers. (Trabert B, Lamb EJ, Scoccia B, et al. Ovulation-inducing drugs and ovarian cancer risk: Results from an extended follow-up of a large United States infertility cohort. Fertil Steril 2013;100:1660–1666)
Using data from the PanScan Consortium, the authors developed an absolute risk model to identify individuals in the general population at elevated risk of pancreatic cancer that considered current smoking, heavy alcohol, obesity, diabetes > 3 years, family history of pancreatic cancer, non-O ABO genotype, rs3790844(chr1q32.1), rs401681(5p15.33), and rs9543325(13q22.1). (Klein AP, Lindström S, Mendelsohn JB, et al. An absolute risk model to identify individuals at elevated risk for pancreatic cancer in the general population. PLoS One 2013;8:e72311)
A two-stage genome-wide association study (GWAS) demonstrated an association of an SBF2 locus (rs10500715 on chromosome 11p15.4) with survival in patients with pancreatic adenocarcinoma of European and Asian ancestry. (Wu C, Kraft P, Stolzenberg-Solomon R, et al. Genome-wide association study of survival in patients with pancreatic adenocarcinoma. Gut 2014;63:152–160)
Using data from the NIH-AARP Diet and Health Study cohort, investigators observed that overweight and obesity at any age are associated with increased pancreatic cancer. (Stolzenberg-Solomon RZ, Schairer C, Moore S, et al. Lifetime adiposity and risk of pancreatic cancer in the NIH-AARP Diet and Health Study cohort. Am J Clin Nutr 2013;98:1057–1065)
An investigation of single nucleotide polymorphisms (SNPs)–environment interactions between 30 confirmed prostate cancer susceptibility loci and 45 pesticides and prostate cancer risk in the Agricultural Health Study observed significantly elevated risk among men who carried two T alleles at rs2710647 in the EH domain binding protein 1 (EHBP1) SNP and had high exposure to malathion and among men who carried two A alleles at rs7679673 in TET2 and had high aldrin use. (Koutros S, Berndt SI, Hughes Barry K, et al. Genetic susceptibility loci, pesticide exposure and prostate cancer risk. PLoS One 2013;8(4):e58195)
A genome-wide association study (GWAS) of prostate cancer among West African men observed an association at 10p14 within an intron of a long non-coding RNA (lncRNA RP11-543F8.2) 360 kb centromeric of GATA3. (Cook MB, Wang Z, Yeboah ED, et al. A genome-wide association study of prostate cancer in West African men. Hum Genet 2013;Nov 2 [E-pub ahead of print])
In an investigation within the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial, elevated levels of serum sarcosine were associated with an increased prostate cancer risk, suggesting that sarcosine may be an early biomarker for this disease. (Koutros S, Meyer TE, Fox SD, et al. Prospective evaluation of serum sarcosine and risk of prostate cancer in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. Carcinogenesis 2013;34:2281–2285)
Based on data from the NIH-AARP Diet and Health Study, age was associated with adenocarcinomas of the small intestine, whereas age, male sex, body mass index, and menopausal hormone therapy use were positively associated with malignant carcinoids. (Cross AJ, Hollenbeck AR, Park Y. A large prospective study of risk factors for adenocarcinomas and malignant carcinoid tumors of the small intestine. Cancer Causes Control 2013;24:1737–1746)
An evaluation of gene expression in 63 paired RNA specimens from frozen normal and tumor thyroid tissues with individual iodine-131 (I-131) doses received from Chernobyl fallout during childhood observed significant associations with expression of eight genes (ABCC3, C1orf9, C6orf62, FGFR1OP2, HEY2, NDOR1, STAT3, and UCP3) in normal tissue and six genes (ANKRD46, CD47, HNRNPH1, NDOR1, SCEL, and SERPINA1) in tumor tissue. PANTHER/DAVID pathway analyses demonstrated significant over-representation of genes coding for nucleic acid binding in normal and tumor tissues and for p53, EGF, and FGF signaling pathways in tumor tissue. (Abend M, Pfeiffer RM, Ruf C, et al. Iodine-131 dose-dependent gene expression: Alterations in both normal and tumour thyroid tissues of post-Chernobyl thyroid cancers. Br J Cancer 2013;109:2286–2294)
A study of genetic markers in immune-related pathways observed increased risk of papillary thyroid cancer associated with single nucleotide polymorphisms (SNPs) (rs6115, rs6112) in the SERPINA5 gene. (Brenner AV, Neta G, Sturgis EM, et al. Common single nucleotide polymorphisms in genes related to immune function and risk of papillary thyroid cancer. PLoS One 2013;8:e57243)


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I first read "The Coming Plague: Newly Emerging Diseases in a World Out of Balance" by Laurie Garrett nearly eight years ago. I have a penchant for "disease books," and as Garrett's book covers hemorrhagic fevers (Ebola, Marburg, Lassa, hantavirus, and Ebola), yellow fever, meningitis, swine flu, AIDS, toxic shock syndrome, Legionnaire's, and cholera, it provided me both with ample disease tidbits and fodder for small anxieties for many months to come. It is absolutely comprehensive in terms of emerging diseases.
I recently picked up the book again, following the World Health Organization's upgrade of the H1N1 "swine flu" virus to pandemic status, for a refresher in all the nasty things out there that can — and may well — kill us. Garrett will also be a guest on "The Colbert Report" tonight: the show will be online tomorrow.
What stands out about her book, even so many years later, is how large a role human behavior plays in the spread of disease. Some of the connections are obvious, such as sexual habits in the case of STDs (such as AIDS) and the well-documented overuse of antibiotics (in both people and animals). Others are less so: genetic recombination of viruses found in human and animal waste (such as cholera) swapping genetic materials as they multiply in bodies of water around the world. Ample time is also given to bumbling bureaucracies, the difficulties people have maintaining appropriate hygiene when in poverty, and religious figures and institutions who put their own idea of morality ahead of the well-being of the individuals at risk. (Think here of Pope Benedict stating that condoms actually contribute to the spread of AIDS to get an idea of what Garrett's discussing here.)
However, what "The Coming Plague" doesn't discuss as such, is the transfer of diseases between humans and animals, and how our industrial food system facilitates this transaction. The book was written in 1995, before avian flu had made an appearance on the world stage, so perhaps such an omission is understandable. Perhaps Garrett will discuss recent developments with Stephen Colbert tonight.
I would love to see a revised edition come out that addresses many of the emerging diseases we're seeing today, from SARS and avian flu to the new H1N1. We've learned so much in the past 15 years, especially with regards to CAFOs serving as breeding grounds for new, nastier, and more drug-resistant bugs (see our Q&A on MRSA, and this New Scientist piece on H1N1). Although it may well be true that there is no causal relationship between Granjas Carroll de Mexico and the H1N1 outbreak in Mexico, that doesn't mean such an outbreak isn't likely in the future.
While Garrett's subject matter is grim, she does end with recommendations for reacting to or preventing future outbreaks. Increased international monitoring of emerging diseases, increased public health spending, and increased access to basic necessities such as sanitation systems and clean drinking water are all common-sense steps that too often fall victim to budget cutting or myopic self-interest.
The global monitoring system is getting a workout these days with the emergence of the H1N1 virus. Let's hope that public health officials worldwide are as aware of Garrett of the coming plague, whatever it might be.
Zoonosis – Now with both MRSA and H1N1 we've got the full rotation – disease going to animals from humans. With SARS and H1N5 it was the reverse – humans getting disease from animals. Because of this, both ways, we practice basic biosecurity at our small pastured farm. We don't want to let our herds become infected by visitors, or us, and of course our customers and family are even more important.
Did you see here TedTalk from 2007, recently released? http://www.ted.com/index.php/talks/laurie_garrett_on_lessons_from_the_1918_flu.html
Very interesting, not least because it is so rational.
Thanks–very interesting talk, and even more interesting comments!
Yes, well, when you have a REALLY popular site Sturgeon's Law kicks in with a vengeance.


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I have been on a journey of self realization for the last year. I have been trying to figure out what I want for the second half of my life. I have been frightened and filled with stress many times as I examine the question:
can you change your life at 50?
Yesterday I got a call from a friend that I haven't heard from in a while. We've literally been friends since we were born. Her mother and my aunt were room mates in the hospital when both she and my cousin were born.
After a long conversation of catch up, and right as we were going to say goodbye, she says:
"Oh, by the way, I quit my job. My last day is Friday."
Ah, hold on. I'm not letting you sign off after dropping that bomb.
Apparently, her revelation to others, had brought her a lot of bad reactions. She left it to the end of the phone call to curb, what she thought would be, a negative response.
"That's freaking awesome!", I exclaimed.
For many, the fifties are what I refer to as the sandwich years. Your own children are grown but not fully independent and you have senior parents who are requiring extra care. You are the meat, stuck in the middle, keeping the whole thing together.
Honestly, I always looked at her like superwoman. I felt inferior to her level of accomplished juggling. Apparently, it has taken a toll on her mentally and physically.
This is not a decision she took lightly. It will carry with it huge financial consequences. She did discuss with her boss going part-time or job sharing, but neither was an acceptable prospect.
So that's that. She's going cold turkey, jobless. She's nervous and excited but relieved. She feels like she can finally take a breath.
I know how she feels, it's almost exactly a year to the day that I stepped away from my working life. Yes, financially we have had to tighten our belts. Yes, I sometimes miss the sense of accomplishment my career brought me. Yes, I miss my fellow employees and the sense of purpose.
Do I regret my decision? Absolutely NOT!
I know it's not for everyone. I know many can not afford to do it. But for me, I had a feeling that I had to make it happen.
Over the next few weeks, we have made arrangements to get together and strategize her next step but for now, what is her plan?
"I'm going to really do Christmas! I'm going to bake!"
I'm happy for her and look forward to helping her in her new journey. Can you change your life at 50? Life can change at any age. You must decide what is important to you, then make a plan. If it is what you truly want and need, you can make it happen.
I know it is scary. If you are not a risk taker like me, follow this 5 step plan for a life change.
Have you made a drastic life altering change late in your life?
I would love to connect with you!
You can find me on PINTEREST, FACEBOOK, TWITTER, INSTAGRAM or Follow my blog with Bloglovin.
Join my support group for bloggers here. Join my Pinterest group board here.


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Jackie Brown's Bail Bondsman
"I'm not sure how a guy wins or loses in this business, but somebody's got to come along and make you lucky. You can't do it yourself." Robert Forster (talking about luck in the movie business)
Academy Award nominated actor Robert Forster finally got his career off to a good start after portraying bail bondsman Max Cherry, who teams up with Pam Grier's title character to pull off a double-cross on a bunch of crooks, in Quentin Tarantino's "Jackie Brown" (1997).
First appearing on the big screen with a small role in John Huston's 1967 drama starring Marlon Brando and Elizabeth Taylor, "Reflections in a Golden Eye," Forster continued to add to his resume roles in such films as "Medium Cool" (1969), "The Black Hole" (1979), "Vigilante" (1983), "The Banker" (1989), "Peacemaker" (1990), "Original Gangstas" (1996), "Psycho" (1998), "Me, Myself & Irene" (2000), "Diamond Men" (2000), "Mulholland Dr." (2001), "Charlie's Angels: Full Throttle" (2003), "Grand Theft Parsons" (2003), "Firewall" (2006), "Lucky Number Slevin" (2006), and "Dragon Wars: D-War" (2007). He will star in the upcoming films "The Code," "Expecting Love" and "Fire Bay."
TV viewers could catch him playing title roles in the TV series "Banyon" (1972-1973) and "Nakia" (1974), as well as playing Marshall Sisco, the father and mentor to Carla Gugino's titular character, in "Karen Sisco" (2003-2004). He also had a recurring role as Ben Huffstodt (2004-2005) in the Showtime series "Huff."
On a more personal front, the 5' 9½" handsome actor has been married twice and has four grown children. He once dated Dani Janssen, widow of David Janssen, and a woman named Marlene, the mother of his son Robert.
School Athlete and Thespian
Childhood and Family:
In Rochester, New York, Robert Forster was born on July 13, 1941, to Robert Wallace Foster, who worked as elephant trainer with Ringling Bros. and Barnum & Bailey Circus before working as an executive for a baking supply company, and Grace Dorothy Foster. His parents divorced in 1949 and his mother committed suicide in 1966. As a tribute to his father, Forster was allowed to hang one of his father's Barnum & Bailey Circus posters in the office of his character "Max Cherry" in the Quentin Tarantino film that earned Forster an Oscar nomination, ''Jackie Brown'' (1997).
Forster attended Rochester's Madison High School where he performed as a song-and-dance man in musical revues. After graduating in 1959, he went to Heidelberg College at Alfred University, in Alfred, New York, (1960-1961) and the University of Rochester on football scholarships and continued to perform in student theatrical revues. He received a Bachelor's Degree in psychology from Rochester in 1963. Afterward, he honed in on his craft in local theater and eventually moved to New York City where he landed his first Broadway role in 1965.
Forster married June Provenzano on May 14, 1966, but they divorced in 1975. In 1978, he married Zivia Foster, but this marriage also ended in divorce in 1980. Forster has three daughters, Elizabeth Foster (born in 1967), Kate Forster (born in October 1969) and Meaghan Foster (born in 1972), and one son, Robert Foster (born in 1965; mother identified only as Marlene).
Diamond Man
"Step No. 1 is you've got to have a good attitude. Step No. 2 is accept all things, deliver excellence to whatever is offered, give it your best shot. And rule No. 3 is never quit. It's not over till it's over." Robert Forster (talking about the rules to succeed in Hollywood)
First become interested in acting while attending Rochester's Madison High School where he performed as a song-and-dance man in musical revues, Robert Forster, a high school and college athlete and occasional school thespian, took an apprenticeship at an East Rochester theater following his graduation from Rochester in 1963. In the local theater, he performed in such plays as ''West Side Story.'' He eventually made a move to New York City in 1965 and landed his first big break as the lead character in Broadway's two-character play ''Mrs. Dailey Has a Lover.''
After the play failed to run its course, Forster returned to Rochester where he worked as a substitute teacher and construction worker until an agent from 20th Century Fox pictures offered him a five-picture deal. He soon landed his movie debut playing a tiny part as young Private Williams, who is torn between a repressed homosexual major (Marlon Brando) and his nymphomaniac wife (Elizabeth Taylor), in John Huston's 1967 drama ''Reflections in a Golden Eye,'' in which he also garnered more attention for his nude scenes. That same year, he also returned to Broadway to play Stanley Kowalski in a revival of "A Streetcar Named Desire," co-starring Julie Harris.
Forester subsequently went on to appear alongside some top Hollywood actors in films like the Western suspense ''The Stalking Moon'' (1968; with Gregory Peck and Eva Marie Saint). He was seen in the semi-documentary "Medium Cool" (1969) and ''Justine'' (1969), George Cukor and Joseph Strick's film adaptation of the novel by Lawrence Durrell.
In the early 1970s, Forster took the title role of a detective in the TV movie "Banyon" and reprised the role in its short-lived NBC series version. He replaced James Farentino as Stanley Kowalski in a Broadway revival of "A Streetcar Named Desire" (1973), opposite Lois Nettleton, before playing the title role in the ABC movie "Nakia" (1974) and its short-lived series spin-off.
Forster spent the rest of the 1970s in the movie "Stunts" (1977) and portraying a small-time cattle rancher in the NBC movie "Standing Tall" (1978). He also made an unaccredited appearance in Lewis Teague's "The Lady in Red" (1979), which was scripted by John Sayles.
The 1980s saw Forster reunite with Teague for "Alligator" (1980), which was also scripted by Sayles, and in his first collaboration with Fred Williamson in "Death Wish" clone "Vigilante" (1983). He also produced, helmed and starred in the detective spoof "Hollywood Harry" (1985), played militant fanatic Abdul in "The Delta Force" (1986), and was picked as a regular in the short-lived ABC series "Once a Hero" (1987), which lasted for only three episodes.
Entering the 1990s, Forster was cast as an extraterrestrial cop in "Peacemeaker" (1990), played a maniac Middle Eastern dictator in the syndicated TV-movie "Counterforce" (1991), and teamed up with Williamson (also the film's producer) in "South Beach" (1992). He also appeared again as Detective Slatter in "Original Gangstas" (1996) and appeared as a cameo in Gus van Sandt's color remake of "Psycho" (1998).
1997 proved to be Forster's breakout year when he was hired by Quentin Tarantino for the movie "Jackie Brown" (1997), for which he received Academy Award and Saturn Award nominations for Best Supporting Actor. His performance in the film also won a Best Supporting Actor at the Kansas City Film Critics Circle Awards.
Talking about Quentin Tarantino and his relationship with the cast, Forster described, "This guy is very smart and he's great to his actors. He wants them to be great. He keeps the stuff fresh. When he gave me the script he knew I hadn't had a big part like this in twenty-five years and he said, 'Here, read this and don't put any pressure on yourself. Just prepare the way you normally prepare.' And I said, 'Oh, what a liberating thing.' This guy is totally secure. He doesn't seem to be worried about anything. He's as good a guy as I have ever worked with.''
Stepping into the new millennium, Forster appeared in the Farrelly brothers' comedy "Me Myself & Irene" and co-starred in "Supernova." He also won a Special Recognition Award at the Hamptons International Film Festival and was nominated for a Best Actor at the Chlotrudis Awards for his outstanding turn as a veteran jewelry salesman who mentors Donnie Wahlberg's character in writer/director Dan Cohen's independent crime drama film "Diamond Men," which he also produced. The film was screened at the Hamptons International Film Festival in October 2000 and was released to select theaters in the U.S. on September 14, 2001, to sparkling reviews.
During the next few years, Forster had a co-starring role in "Lakeboat" (2001), starred as Detective Harry McKnight in David Lynch's "Mulholland Dr." (2001), and was cast in the made-for-TV movie "Murder in Greenwich" (2002), based on the book by Mark Furhman about the story of Martha Moxley's unsolved murder. He was also cast as Marshall Sisco, a retired Miami police officer turned private investigator and Karen's (played by Carla Gugino) father, confidant, counselor, and confessor, in the ABC crime drama series "Karen Sisco" (2003-2004).
Afterward, Forster was cast in the low-budget comedy "Grand Theft Parsons" (2004) and had a recurring role as Ben Huffstodt (2004-2005) in the Showtime series "Huff." He also narrated the book on tape for Robert B. Parker's "Double Play" in 2004.
During 2006 and 2007, Forster could be seen in the films "Firewall," starring Harrison Ford, "Lucky Number Slevin," featuring Josh Hartnett, Bruce Willis, and Lucy Liu, "Wild Seven," co-starring James M. Hausler, Robert Loggia, and Richard Roundtree, "Jack and Jill vs. the World," starring Freddie Prinze Jr. and Taryn Manning, "D-War," co-starring Jason Behr and Amanda Brooks, and "Rise," a supernatural thriller in which he teamed up again with Lucy Liu. He also appeared in the minor films "Touching Home" and "Cleaner," as well as the 12-minute short film "Grampa's Cabin" (all three in 2007). In November 2007, TV viewers saw him guest starring in an episode of the ABC long-running soap opera "Desperate Housewives."
Forster is currently working on a dramatic miniseries called "Would Be Kings" and the upcoming films "The Code," a mob drama by Mimi Leder starring Morgan Freeman, Antonio Banderas and Radha Mitchell, "Expecting Love," a romantic comedy by writer/director Lukasz Karwowski, and "Fire Bay," a historical drama by writer/director Randall Fried.
Hamptons International Film Festival: Special Recognition, "Diamond Men," 2000
Kansas City Film Critics Circle: Best Supporting Actor, "Jackie Brown," 1998


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Thursday, October 18, 2007
Kazu's MidT.
Here goes another self portrait. Well this time I decided to get away from the traditional way of self portrait and went berserk. Main concentration was color balance and harmony of intense and saturated colors.
~Well until next posting_ (that would be in a while lol.)
Working on a illustration on my brothers request, and some other geisha crap. Ill post them up when I getz zeh time~
"The Witness"
Another acrylic brainstorm. Just decided to paint from memory to recall forms. Notice the exaggerated use of reds to push the message of fright. Dedicated to Armenian Genocide.
"Crimson Rain" Memorial for the Dead
In Class Acrylic Paintings
Bryan's request. His been bugging me all this time. I hope you satisfied!
As you can see I used different color scheme for each painting. Hopefully it will get better.
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Bush annoyed by US media war coverage
President Bush is irritated by US media assessments of the Iraq war, especially their questions about the duration of the war.india Updated: Mar 29, 2003 09:40 IST
US President George W Bush is irritated by hand-wringing US media assessments of the war against Iraq, especially their questions about the duration of the conflict, top aides said on Friday.
The officials, speaking on condition of anonymity, cited Bush's "frustration" with such media worries and especially with suggestions that the administration forecast a quick and easy victory.
"There's a difference between saying, 'what is your expectation about how long a war will last,' and some of the tone that has come out about 'why isn't it over yet," echoed White House spokesman Ari Fleischer.
"It is fair to say that ... Just like Afghanistan, we are seeing a repeat of questions being raised about 'why has it taken so long,' when the President is always focused on the fact that it will take as long as necessary," he said.
"The President believes ... That we are making very good progress in the war, it is on track, and he is very satisfied with the results," said Fleischer.
US media on Friday criticised the US-led war effort, even as military officials said logistical problems and unexpected Iraqi tactics will probably lengthen the conflict.
First Published: Mar 28, 2003 23:39 IST


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Matt Gone is one of the worlds most tatttooed people with over 98 percent of his body tattooed – including his genitals and tongue. 80 artist has tattooed his body with incredible complex designs.
Matt Gone will entertain with his freakshow and be this year speaker at 50 Shades Of Ink!!!


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If you are thinking about buying tile for your house, then I just want you to know that there is still value in getting cheap tile. Most people think that just because the tile is cheap that it is not worth it, however, that is not true. Just because tile is cheap doesn't mean it is broken or weak, all it means is that it is probably not the latest style or trend. It is because of this that companies are pretty much forced to get rid of it in order to make room for the new arrivals.
Something that I highly recommend is that every homeowners looks to buy cheap tile as opposed to spending a lot of money on it when they could have purchased the same thing for less. Don't make the mistake that so many people make when it comes to buying tile, buy what you can comfortably afford. One more thing, use the tips below in order to get the cheapest tile possible and get the same look that you were going for.
Ways To Get Cheap Tile
Buy Tile Online – One thing I would do is buy tile online. The reason you should do this is because you will get a much better deal online than you will at any local retail store. Just know that when you buy items online you are normally buying it directly from the source and this can save you a lot of money.
Look For Sales – Something else you should do is always be on the lookout for sales. By finding sales you can not only save money on the tile, you might be able to find other things as well. Just keep this in mind because a good sale is not worth missing.
Get Package Deals – A lot of people buy tile and then they wait to find somebody to install it. What you should do instead of taking this route is to find somebody that knows where to get cheap tile and will install it themselves. By getting somebody to buy the time for you they will most likely charge you less for the installation and that is sometimes the most expensive part.
There are many ways to get tile for a cheap price, but you need to know what those ways are. Just because you find a good deal somewhere doesn't mean that is the best deal, look around and see if you can find the tile cheaper someplace else.


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Kendrys Morales' Return to Seattle Was Necessary
He came. He saw. He had a .259 on-base percentage. That is the story of Kendrys Morales with the Minnesota Twins.
Only 47 days after signing Morales to a pro-rated $12 million dollar contract, the Twins shipped him back to Seattle for right-handed reliever Stephen Pryor. This puts Morales in the same place where he turned down a three-year, $30 million contract this winter. And it could be exactly what both he and the Mariners needed.
For Morales, he gets out of Minnesota and onto a team that can actually make the playoffs this year. The Mariners get the man who blasted 23 homers for them last year. It's all great, right? Not so fast, my homie.
The Long Road Back
As noted in the lede, Morales hasn't exactly been mashing taters this year. He has, rather, gently filleted them.
In 162 plate appearances since signing on June 8th, Morales has hit .234/.259/.325 with a .255 weighted on-base average (wOBA). This gives him a nERD of -0.90, the 333rd-ranked total in the league. If you're new to numberFire, nERD is our stat that measures the number of runs a batter is worth above or below an average hitter if he were to record 27 plate appearances in a game. Negative is bad. Morales has been bad.
But, when you consider Morales's situation, it may not be fair to look at his season as a whole. Because he was out of options, he didn't have the luxury that Stephen Drew had to bop down to the minors and tune up before making a full-fledged return. He was thrown into the fire and asked to re-gain his timing on the fly.
To solve for this, let's look at Morales starting July 7th, 29 days after he arrived in Minnesota. That should give us a better idea of what he'll bring to the Mariners.
Over that time, Morales has certainly been better than what he was in June. Even with the improvement, dude has been riding shotty on the struggle bus. In 55 plate appearances, Morales's slash is up to .269/.291/.385 with a .294 wOBA. None of those marks (minus possibly the batting average) are anywhere near where the designated hitter on a contending team should be. Unfortunately, he still may be an upgrade for the Mariners.
Why the Mariners Needed Morales
Morales's numbers with the Twins were fairly atrocious. This means he should be a perfect fit for the present Seattle offense.
Of the 30 MLB teams, 27 of them have a higher team wOBA than the Mariners. The only two beneath them are the Phillies and the Padres who have a combined .436 win percentage this year and are in the National League. That's some gross territory.
Speaking of the National League, Seattle may as well re-locate to the senior circuit. A.L. rules allow the Mariners to use a designated hitter, but they might be better not even doing so. Their designated hitters have done so poorly this year that their pitchers could possibly give them a run for their money.
On the season, players batting as the team's designated hitter have belligerently stumbled to a .196/.277/.293 slash and just 17 extra-base hits. Madison Bumgarner is out-slugging them by 207 points. How in the world is this team contending for the playoffs?
Obviously, this team's pitching staff is one of the illest of the ill. They have scored the second fewest runs in the A.L. this year, and they still have a plus-52 run differential. This means that any uptick in offensive production, no matter how small, should benefit them in a huge way. The question now is whether or not the 2014 version of Morales can provide even that.
At the end of the day, it's a gamble for the Mariners. They owe Morales over $4 million for the rest of the year. If he keeps hitting like he has been, they will struggle to regain that second wildcard spot. But, if he can find even some of that 2013 production, the Mariners should at the very least make a great push for that final playoff spot until the end.


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PARKSVILLE – If a disaster struck locally, would be you ready to leave your home at a moment's notice?
It's a question organizers will ask during Emergency Preparedness Week, running from May 7 to 13 with an expo on May 27 at the Parksville Curling Rink.
Aaron Dawson, the City of Parksville's emergency program coordinator, said people have to be ready for anything at any time given the number of possible disasters which could hit the Mid-Island area.
"What we encourage people to do is have a grab-and-go kit," he said. "Have some way of thinking about and knowing about what they're going to need to do if we knock on there door and say 'in 10 minutes you need to evacuate.'"
He said many have never considered what they'd do in an emergency, which is why their hosting the awareness week.
"We're there if you've got questions about where you are with your preparation," he said. "If you're just starting to be prepared because you're new to the area or whatever we can do to assist you. We're going to be there to do one-on-one consultation. We have lots of good material to hand you to take away to get prepared properly."
There was a one-on-one session May 8 at the Qualicum Beach Town Hall and another planned for May 11 at Parksville City Hall.


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"Why were you there exactly?" someone who was obviously tired of reading my endless sedih entries, questioned me impatiently. I almost laughed when I saw the exasperation on her face, uncertain if I was injecting suspense to the way I write or boredom instead. Truthfully, I am savouring every single detail of my trip, unwilling to let the memoir melt down on me like an ice cream on a hot Sunday afternoon. I am still in my dreams folks, unawakened by the reality, so do pinch me, every time I go astray ;o).
As all might have guessed, my travel to the States was to pursue knowledge on cake decorating with the Sugarflours Team. We, like the rest of the other international cake enthusiasts there, participated head to head, shoulder to shoulder kneading our way to complete the teachers' training course before we were conferred the PME Trainer's certificate. The modules had our sleeves rolled up from 9 to 5 with an hour lunch break in between. It was one week of hard labour for the Malaysian contingent, with us trying to acclimatize to the weather and different time zone. We were at most times walking deep in our slumber with our eyes wide opened building cakes and constructing royal icing bridges. The most difficult part was to stay awake during the round up sessions. I almost dozed and fell off my chair on one occasion.
All in all it was a wonderful opportunity to rub shoulders with established cake decorators whose work have constantly left me gawking and gaping online. But through an event such as this, I was privileged to meet and talk to them personally, exchanging ideas on a subject which is dearest to us. Therefore I would like to take this opportunity to extend my heartiest gratitude and appreciation to participants from Argentina, Mexico, South Korea, Taiwan, India, United Kingdom, Canada, Spain and the United States for their support and friendship. I am humbled by the professionalism and the hospitality shown.
Below are glimpses on "That thing we do"
Watie looking delighted with the Sugarflours name tag. This was our formidable looking work station. It shouted "serious work only" Yikes!...Yawn...
My roses are not as dainty as Lisa's the instructor. Maybe because she is English, yes, that's why. But my hibiscus isn't any better either ha ha ha.
Glorious food, vegetarian food! Sayur -stir fried, blanched, boiled, souped, sandwiched, and mashed, presented in all forms imaginable. To compensate we bagged the cookies and crisps home.
We had to say "cheese" in all the participants' languages. Keju included. So the Malaysian contingent pouted their lips to mouth "kejuuuuuuuuuuuuuuuu" for the camera!
Stay tune to "That thing we do too" next folks!


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Courtice Flea Market
1696 Bloor St. East
Downsview Park Merchants Market
40 Carl Hall Road, Downsview Park Toronto, M3K 2B6 Phone: 416-638-2525 Manager/Owner: Robert McBride, Market Manager Web site: www.dpmarket.com Indoor Market Open Year Round Sat. and Sun. 10am-6pm. Largest Merchant's Market in Ontario, Something for everyone a wide variety of merchandise, from antiques & collectibles to new items. 500 vendors, farmers market, & large international [...]Full listing and market conversation →
Grand River Flea Market
261 Hespeler Rd
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46 Turner Crescent
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3 Brant School Road
Stouffville Country Market
12555 10th Line North
The Pickering Markets & Trade Centre
1400 Squires Beach Road
Pickering, ON L1W 4B9
Phone: 905-426-3387Full listing and market conversation →


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English Language Arts, Grade 12 Module 4, Teacher Set
Paths to College and Career
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Paths to College and Career is a new, comprehensive English Language Arts curriculum for grades 6 to 12 built from the ground up over a three-year period to address the Common Core State Standards (CCSS) for English Language Arts and Literacy. It reflects a deep understanding of the standards and assessments, and is written with a focus on the shifts in instructional practice and student experiences the standards require. It includes daily lesson plans, guiding questions, recommended texts, scaffolding strategies, and other classroom resources.
Paths to College and Career provides teachers, schools, and districts with a concrete and practical ELA instructional program that engages students with compelling and complex texts. At each grade level, Paths to College and Career delivers a yearlong curriculum that develops all students' ability to
* read closely and engage in text-based discussions,
* build evidence-based claims and arguments,
* conduct research and write from sources, and
* expand their academic vocabulary.Paths to College and Career's instructional resources address the needs of all learners, including students with disabilities, English language learners, and gifted and talented. The curriculum is flexible, user friendly, engaging, and purposefully built to prepare students for career, college, and life.
In Module 4 of Grade 12, students outline, analyze, and evaluate the argument that Michelle Alexander makes in The New Jim Crow: Mass Incarceration in the Age of Colorblindness, paying attention to her use of rhetoric to convey her ideas.


text: This is where you can talk to other members of this group and get to know one another. Share were they got their characters from. Whats their favorite anime, If they prefer demopns or vampires. Whatever they like to do. Etc etc. Just have fun and Discuss what you please!


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I love mascara - it's my make-up muse and if I were to only ever able to wear one make-up product again, it would be mascara without a doubt. It opens up your peepers, makes you look half human and even without all of its make-up counterparts it stands alone looking pretty cool.
My Aunt (who lives in the US) recently introduced me to the Maybelline 'Lash Stiletto' mascara which intends to lengthen the lashes by 70%. If I am looking for the USP of a mascara it has to be that it provides length and everything else is a bonus. The wand is also a very important factor, I like slim wands with rubbery or very streamline bristles and that is obviously what makes this mascara pretty awesome.
The formula is non clumping and isn't ridiculously watery - no smudging to be seen here. I am pretty sure that i've seen this mascara on the UK market a few years ago and that it has since been discontinued which is a shame as I have gotten on well with it.