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Treating Hepatitis B and C
Hepatitis B
Treatment for chronic hepatitis B virus (HBV) infection has not advanced as fast as HIV and hepatitis C therapy in recent years, but approval of new drugs has led to higher response rates.
Nucleoside/nucleotide analogs are the mainstay of hepatitis B treatment. FDA-approved options include Baraclude (entecavir), Epivir (lamivudine or 3TC), Hepsera (adefovir dipivoxil), Tyzeka (telbivudine), and Viread (tenofovir disoproxil fumarate). Emtriva (emtricitabine) is also active against HBV, but has not yet been approved for this purpose. These are all pills taken once daily. Conventional interferon and pegylated interferon alfa-2a (Pegasys) are also approved for treating hepatitis B. The more potent formulation, Pegasys, is injected once weekly.
Not everyone with hepatitis B needs treatment, depending on the extent of liver damage and other factors. A complete cure, meaning HBV clearance and development of protective antibodies, is uncommon. But most people can achieve viral load suppression, which lowers their risk of developing liver cirrhosis and liver cancer. Treatment usually lasts for at least one year, and many people stay on nucleoside/nucleotide analogs for several years to maintain viral suppression.
There are three ways to measure hepatitis B treatment response. Virologic response means suppression of viral replication, ideally reaching undetectable HBV DNA viral load in the blood. Biochemical response is normalization of the liver enzyme alanine aminotransferase, or ALT. Serological response refers to clearance of HBV antigens and development of antibodies (seroconversion).
U.S. and European treatment guidelines recommend Baraclude or Viread monotherapy for first-line hepatitis B treatment for HIV-negative people. These drugs offer the best overall response rates and a high barrier to resistance. There are two types of HBV, hepatitis B "e" antigen (HBeAg) negative and positive, the latter being harder to treat. In clinical trials, virologic response rates for Baraclude and Viread were 90% and 93%, respectively, for HBeAg-negative people, and 67% and 76% for HBeAg-positive people. Both drugs are generally safe and well tolerated, though tenofovir can sometimes cause bone loss and kidney impairment. Combining nucleoside/nucleotide analogs does not significantly improve response for hepatitis B treatment-naïve people, but it may be beneficial for people with drug-resistant HBV.
Lamivudine, which is available in a generic formulation, is the least expensive treatment, but drug resistance is common. Pegylated interferon promotes HBeAg seroconversion, and combining interferon with nucleoside/nucleotide analogs improves effectiveness. But interferon can cause difficult side effects, and combining it with Tyzeka can cause peripheral neuropathy.
Viread, Epivir, and Emtriva are active against both HBV and HIV. Guidelines recommend that people with HIV and HBV co-infection should include dually active drugs in their antiretroviral regimen. HIV/HBV co-infection should be managed by clinicians who have experience treating both diseases, since using these medications incorrectly can lead to drug resistance in one or both viruses.
Hepatitis B can be prevented by a three-dose vaccine. This is now included in routine infant vaccinations and is recommended for many adults, including gay men, pregnant women, and people with HIV or hepatitis C.
Hepatitis C
Treatment for hepatitis C virus (HCV) infection has advanced dramatically in the past few years as direct-acting antiviral agents, or DAAs, have improved cure rates and shortened treatment duration.
The main measure of hepatitis C treatment success is virologic response, or reduction of HCV RNA. Viral load is typically measured after four weeks on treatment (rapid virologic response, or RVR), after 12 weeks (early virologic response, or EVR), at the end of treatment, and after finishing treatment.
Sustained virologic response (SVR), or continued undetectable HCV viral load 24 weeks after completing treatment, is traditionally considered a cure. The FDA recently said SVR at 12 weeks post-treatment can also be considered a cure. Sustained response can halt liver disease progression and lowers the risk of developing cirrhosis and liver cancer.
Not everyone with hepatitis C needs treatment, but it is recommended for people with at least moderate liver damage, usually determined by a liver biopsy. Treatment during acute infection (the first six months after infection) has a very high success rate, but most people do not realize they are infected this soon. Overall, about 25% of people clear HCV spontaneously without treatment, but the proportion is lower among people with HIV.
The previous standard of care for chronic hepatitis C was pegylated interferon alfa-2a (Pegasys) or alfa-2B (PegIntron) injected once weekly plus a weight-adjusted oral dose of ribavirin. Treatment duration is 48 weeks for people with difficult-to-treat HCV genotypes 1 or 4 and 24 weeks for those with genotypes 2 or 3. The overall SVR rate for HCV mono-infected people is about 75% for genotypes 2 or 3, but less than 50% for genotype 1. For the most difficult-to-treat groups of patients, response rates can be as low as 5%.
Several factors influence how well interferon-based therapy works. In addition to HCV genotype, high pre-treatment HCV viral load, advanced liver fibrosis or cirrhosis, insulin resistance, and HIV co-infection are associated with poorer response. People trying treatment again after previous non-response do not do as well as those being treated for the first time. People of African descent generally do not respond as well as white patients.
In 2009, researchers discovered that the latter two factors are largely attributable to variations in the IL28B gene. People with the favorable "CC" gene pattern respond best to interferon, people with the "TT" pattern have the lowest response rates, and people with the "CT" pattern are in between.
Pegylated interferon causes notorious side effects, including flu-like symptoms (fever, chills, fatigue, muscle aches), depression, and low white blood cell count. Ribavirin can cause anemia due to red blood cell destruction. These side effects may be severe enough that people avoid going on treatment, stop treatment prematurely, or lower their drug doses.
The current standard of care for hepatitis C combines direct acting antivirals with the previous standard of care, pegylated interferon plus ribavirin. DAAs work by targeting different steps of the viral lifecycle. Polymerase inhibitors, which interfere with copying viral genetic material, and protease inhibitors, which block construction of new viral particles, are familiar from HIV treatment. NS5A replication complex inhibitors target an HCV enzyme that works in conjunction with polymerase.
In 2011, the FDA approved the first two DAAs for genotype 1 chronic hepatitis C, the protease inhibitors Incivek (telaprevir, developed by Vertex) and Victrelis (boceprevir, developed by Merck). In pivotal clinical trials, adding one of these drugs to pegylated interferon/ribavirin raised overall treatment response rates significantly, both for HIV-negative and HIV-positive patients.
Both drugs are taken three times daily with pegylated interferon/ribavirin (Incivek for 12 weeks, Victrelis for 28 or 36 weeks), followed by continued treatment with pegylated interferon/ribavirin alone. Treatment-naïve people with good early viral suppression can stop treatment sooner (at 24 or 28 weeks), while others continue treatment through week 48.
In Phase 3 clinical trials of HIV-negative people, Incivek SVR rates were 79% for previously untreated people, 86% for prior relapsers, and 32% for prior null responders (those who previously had little or no decrease in HCV viral load). Victrelis SVR rates were 90% for previously untreated people and 66% for prior relapsers and partial non-responders (null responders were excluded).
So-called difficult-to-treat patient groups do not respond as well to hepatitis C therapy but may have a more urgent need for treatment. People with liver cirrhosis can be successfully treated with triple therapy including Incivek or Victrelis, but they have a higher frequency of side effects; studies of liver transplant recipients are underway. HIV/HCV co-infected people using Incivek or Victrelis can achieve response rates close to those of HCV mono-infected people with similar side effects. However, due to drug-drug interactions, these DAAs should not be combined with certain antiretrovirals.
Not surprisingly, adding another drug to the mix can increase adverse events. The most notable side effect of Incivek is skin rash, while Victrelis can cause anemia. The tradeoff is shorter treatment duration and a better chance of achieving a cure.
HCV Drugs in the Pipeline
Several new HCV protease inhibitors are now in clinical trials including asunaprevir (BMS-650032, developed by Bristol-Myers Squibb), danoprevir (RG7227, Roche/Genentech), faldaprevir (BI 201335, Boehringer Ingelheim), simeprevir (TMC435, Janssen), sovaprevir (ACH-1625, Achillion), vaniprevir (MK-7009, Merck), ABT-450 (Abbott), and GS-9256 (Gilead Sciences).
Experimental polymerase inhibitors include the nucleoside/nucleotide analogs mericitabine (RG7128), sofosbuvir (GS-7977), and VX-135 (Vertex). Non-nucleoside polymerase inhibitors include setrobuvir (ANA598, Roche), tegobuvir (GS-9190), ABT-333, BI 207127, BMS-791325, and VX-222.
NS5A replication complex inhibitors under development include daclatasvir (BMS-790052), ABT-267, and GS-5885. Other therapies under study for hepatitis C include the cyclophilin inhibitor alisporivir and pegylated interferon lambda, a new type of interferon that works as well as pegylated interferon alfa but with fewer side effects.
Several experimental DAAs are taken once daily with treatment durations as short as eight weeks. In general, the new drugs are better tolerated than current standard-of-care treatment. For many of these drugs, the IL28B gene pattern does not matter as much as it does for interferon. However, HCV subtype has emerged as an important factor, with subtype 1b being easier to treat than 1a.
Several DAA candidates have demonstrated good outcomes in combination with pegylated interferon alfa and ribavirin in Phase 2 clinical trials and are now moving into Phase 3 testing.
Many people with hepatitis C are waiting for all-oral, interferon-free regimens, several of which (with or without ribavirin) are currently in Phase 2 or Phase 3 clinical trials. Like antiretroviral therapy for HIV, combining medications from different classes improves effectiveness and lowers the risk of drug resistance.
Regimens that combine an HCV protease inhibitor and a NS5A inhibitor appear especially potent. For example, a 12-week regimen of sofosbuvir plus daclatasvir cured 90% to 100% of treatment-naïve people with HCV genotypes 1, 2, or 3. A 12-week triple regimen of sofosbuvir, GS-5885, and ribavirin has so far produced 100% sustained response at four weeks post-treatment in an one study, while another is looking at sofosbuvir/GS-5885 in a co-formulated pill without ribavirin.
Daclatasvir plus asunaprevir for 12 weeks cured about 80% of people with HCV subtype 1b, rising to 100% when ribavirin was added. The first two drugs plus BMS-791325 cured more than 90% of people with both HCV subtypes. Almost all genotype 1b patients -- even null responders -- were cured with a four-drug, oral regimen of ABT-450, ABT-333, ABT-267, and ribavirin taken for only eight weeks, as well as various three-drug combinations taken for 12 weeks. Faldaprevir, BI-207127, and ribavirin for 28 weeks cured 80% of genotype 1b patients, with a cure rate almost as high for those with cirrhosis.
In summary, hepatitis C treatment has improved markedly with the advent of direct-acting drugs. People who do not respond to or cannot tolerate interferon have the most to gain from the new DAAs. Interferon-free combinations are now entering late stages of testing and some experts predict that the first such regimens may be available in two to three years. Some people will likely continue to need pegylated interferon for the foreseeable future, but adding DAAs will shorten treatment and increase the likelihood of a cure.
Liz Highleyman (email@example.com) is a San Francisco-based medical journalist specializing in HIV and viral hepatitis, and is editor-in-chief of HIVandHepatitis.com.


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The first part of a series of five articles on the social networking today. This is a very interesting guide that will give you lots of useful information on the subject. [note mg]
In today's blogosphere a lot of discussion is going on about various aspects of positioning and growing a blog. Even though the space gets more and more crowded every day, and the game is changing constantly, there are still some things everyone tells you to do – things considered as mandatory for any kind of success.
Among various aspects of promotion, advertising, search engine optimization, social media, and all kinds of other stuff lies the need of contacting other, fellow bloggers, and being in touch with people in general.
Read more: http://www.hongkiat.com/blog/networking-guide-for-bloggers-why-networking-important/
Via Martin Gysler


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Your body is made up of trillions of living cells. Normal body cells grow, divide into new cells, and die in an orderly way. During the early years of your life, normal cells divide faster to allow you to grow. After you become an adult, most cells divide only to replace worn-out, damaged, or dying cells.
Cancer begins when cells in a part of your body start to grow out of control. There are many kinds of cancer, but they all start because of this out-of-control growth of abnormal cells.
Cancer cell growth is different from normal cell growth. Instead of dying, cancer cells keep on growing and form new cancer cells. These cancer cells can grow into (invade) other tissues, something that normal cells cannot do. Being able to grow out of control and invade other tissues makes a cell a cancer cell.
In most cases the cancer cells form a tumor. But some cancers, like leukemia, rarely form tumors. Instead, these cancer cells are in the blood and bone marrow.
When cancer cells get into the bloodstream or lymph vessels, they can travel to other parts of the body. There they begin to grow and form new tumors that replace normal tissue. This process is called metastasis.
No matter where a cancer spreads, it is always named for the place it started. For instance, breast cancer that has spread to the liver is still breast cancer, not liver cancer. Likewise, prostate cancer that has spread to the bone is metastatic prostate cancer, not bone cancer.
Different types of cancer can behave very differently. For example, lung cancer and breast cancer are very different diseases. They grow at different rates and respond to different treatments. That is why people with cancer need treatment that is aimed at their own kind of cancer.
Not all tumors are cancerous. Tumors that aren't cancer are called benign (be-nine). Benign tumors also can cause problems – they can grow very large and press on healthy organs and tissues. But they cannot grow into other tissues. Because of this, they also can't spread to other parts of the body (metastasize). These tumors are almost never life-threatening.


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Come Back from Let-Downs and Discouragements
"We would never learn to be brave and patient if there were only joy in the world," wrote Helen Keller. How I wish she were wrong. Disappointments leave us with the unpleasant task of squashing, crushing, and pinching life's lemons to extract anything to transform into lemonade. Let these techniques help you more easily turn sour into sweet as you take steps to overcome disappointment.
Therese J. Borchard writes the Beyond Blue blog on Beliefnet. Her new book, also called Beyond Blue, has just been published.


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A close friend of my mother worked at DEC in the 1970s and 1980s. She recently passed away, and in sorting through her estate, my mother discovered some reel-to-reel magnetic tape. We are curious about what might be on it. I haven't yet seen a picture of it, but Wikipedia tells me this is most likely DECtape.
Is there any chance the data on it is still good? It was not preserved with great care, but as far as we know it has also never been particularly abused. Just left in a box and moved a few times.
If the data is still valid, do we need to dig up a PDP or VAX or read it, or is there a more modern option?


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ABP works closely with its customers to handle a wide range of steel and other metals, including recycled metal for export. Together with our customers, we handle more than 4.5 million tonnes of metals each year.
13 of our ports handle metals and we have dedicated facilities across our group. On the Humber, the ports of Hull and Goole have all-weather steel handling terminals, providing a 'one-stop-shop' for ship's agency, cargo handling, storage & distribution on behalf of our customers.
In South Wales we have a steel terminal at the Port of Newport that currently handles over 500,000 tonnes of steel each year. This facility has 300,000sqm of covered storage, with an undercover rail siding served by gantry cranes. In addition, the South Side Queen Alexandria dock in Cardiff has a specialist steel terminal complete with a long product manufacturing plant and gantry cranes.
We recognise the importance of long-standing relationships with both international steel producers and customers. Our facilities are operated by companies who are leaders in this field. With continuous investments in equipment, employees and state-of-the-art IT systems, we aim to provide outstanding facilities and to offer exciting opportunities for new and existing businesses.
Our commercial team would be pleased to put together a package of port facilities tailored for your business in our unique network of 21 ports.


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Google under fire in UK MPs' report into privacy
An influential group of UK lawmakers has called on Google to introduce an algorithm to remove search links found to be in breach of privacy - or face legislation to force it to do so.
It follows complaints from ex-Formula One boss Max Mosley about the difficulty he faced in getting a video removed from the internet.
The search giant argued it was not its job to monitor net content.
The cross-party committee said this argument was "totally unconvincing".
The reportby a committee of MPs and peers was commissioned by the government to look into privacy and free speech issues after a series of high profile super-injunctions were made public last year.
Celebrities including Ryan Giggs found that gagging orders against newspapers were routinely flouted online. In Mr Giggs' case, the details of his super-injunction were mentioned at least 75,000 times on Twitter, the committee said.
Its report said that online firms needed to be brought in line with offline media in such cases.
"We recommend that, when granting an injunction, courts should be proactive in directing the claimant to serve notice on internet content platforms such as Twitter and Facebook," it said.
Some of the harshest criticism was reserved for Google.
"Where an individual has obtained a clear court order that certain material infringes their privacy and so should not be published, we do not find it acceptable that he or she should have to return to court repeatedly in order to remove the same material from internet searches," the report said.
Mr Mosley had testified that having successfully sued the News of the World over secret film it had taken, he had gone on to spend more than £500,000 on legal action to force others to remove the material from the internet.
He said that he had confronted Google saying: "Here are the pictures. We know which ones they are. Simply programme your search engine so they don't appear."
But Google had argued that while it could create algorithms to filter such results in future, it would not be desirable for it to proactively monitor the net.
The committee had greater sympathy with Mr Mosley.
"We find their [Google's] objections in principle to developing such technology totally unconvincing.
"Google and other search engines should take steps to ensure that their websites are not used as vehicles to breach the law and should actively develop and use such technology. We recommend that if legislation is necessary to require them to do so, it should be introduced," the report concluded.
In response, Google told the BBC: "Google already removes specific pages deemed unlawful by the courts. We have a number of simple tools anyone can use to report such content, which we then remove from our index.
"Requiring search engines to screen the content of their web pages would be like asking phone companies to listen in on every call made across their networks for potentially suspicious activity."
It has not been the best week for Google and its long-held promise not to censor content.
In Japan a court has ordered it to remove certain terms from its auto-complete search function after a man complained that his name was constantly being linked to criminal activity on Google.


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We offer three sizes: the 1/2" diameter for spindles, the 7/8" diameter for rungs, and the 1-1/4" diameter for legs and posts, as well as canoe paddle shafts.
The machined steel bodies are fitted with hardwood handles shaped for comfort and control when either pulling or pushing. The machined toe and the two thumbscrews are solid brass. The high-carbon steel blades are 0.040" thick, hardened to Rc48-52, and come with a finely ground 45° cutting edge.
Full instructions included.
These tools are a joy to use and are an excellent companion for spokeshave use.
Made in Canada.


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Featured Announcements
Viewing entries posted in October 2013
OpenCL now Available on Dirac GPU Cluster
October 30, 2013 by Francesca Verdier
As requested by many Dirac users, NERSC is migrating Dirac to a newer Linux version to enable capabilities such as OpenCL. We aim to convert the whole Dirac system to Scientific Linux 6.3 by Mid-November.
We have migrated the beta nodes to Scientific Linux 6.3. Please run some test jobs to make sure your code will work in the new system. In particular, please test your MPI+Cuda codes in a multi-node environment.
You can get to one of these nodes with:
qsub -I -V -q dirac_int -l nodes=1:ppn=8:beta
Or to get 2 nodes:
qsub -I -V -q dirac_reg -l nodes=2:ppn=8:beta
Inside the job you need to load the latest cuda and SL6 flavor of gcc:
module unload cuda
module load cuda/5.5
module unload pgi
module load gcc-sl6
If you dont have access to Dirac you may request access:


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The union representing East Stroudsburg Area School District's support staff workers has authorized a strike after negotiations over the past two years failed to produce a new contract.
The union representing East Stroudsburg Area School District's support staff workers has authorized a strike after negotiations over the past two years failed to produce a new contract.
"The union leadership was given the authority by a vote of the general membership to give the school district a strike notice when or if they believe it is necessary to get a fair contract," said Matt Gruenloh, representative of the East Stroudsburg Area Education Support Professional Association.
The union, which has approximately 570 members, has been without a contract since the summer of 2011. The vote was taken March 20 during the union's general membership meeting.
"The support staff plays a vital role in the lives of district students," Gruenloh said. "East Stroudsburg Area School District needs qualified, trained, caring people in every job in every school. Many times the support staff are the first people parents and students see in the morning and the last they see in the evening."
Support staff include: bus drivers, business office personnel, cafeteria workers, custodians, instructional aides, information technology department staffers, maintenance, mechanics, health room assistant nurses, secretaries, student helpers and hall monitors.
The strike authorization does not mean that there will be a strike, but the union negotiation team now has the authority to call for one.
The district and the support staff are exchanging salary and health care proposals. There are also unresolved issues related to working conditions, including but not limited to vacations, holidays and uniforms. Wage freezes have been discussed, Gruenloh said.
The district approved increases for the district's administrative staff less than two weeks ago through the 2014 —15 school year, including 1.5 percent raises for 2013, retroactive to Jan. 1.
East Stroudsburg Superintendent Sharon Laverdure declined to comment on the discussions, citing standard policy regarding contract negotiations.


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Security system installation is a natural for electrical contractors that already pre-wire residences for alarms. The challenge is selling the idea to builders and homeowners.
The booming home-security installation market is a hard market to get a handle on for CEE News readers. While the market offers excellent installation opportunities to electrical contractors, it offers even better opportunities to alarm-system contractors, alarm-system manufacturers and to homeowners themselves.
Burglar-alarm manufacturers, such as ADT Security Services Inc., and burglar-alarm contractors perform the lion's share of home security installations. But, increasingly, electrical contractors offer security systems to homeowners as part of an overall package of power and structured data-wiring installations. Some electrical contractors even design their own systems, customizing security for upscale clients' homes.
The residential security market grew more than 30% in both 1998 and 1999 - nearly double the growth rate of the small commercial security market - according to an ADM magazine survey. The survey also found that alarm-installation firms averaged 128 residential but only 85 nonresidential new customers in 1999. Analysts expected the home market to crack the $1 billion mark in 2000. Tech-savvy and security conscious homeowners are doling out big bucks for alarm systems, but they're cheapskates compared to industrial and commercial business owners, who spent an estimated $15 billion on security last year.
"It's a very small percentage of U.S. homes that are protected, but it's been growing very fast. All the members of the New Hampshire Alarm Association are very healthy work-wise," said association vice president Glen Smith to the Eagle-Tribune, Kingston, N.H. Smith has installed security systems in Massachusetts and New Hampshire as owner of International Signal Inc., a firm that has specialized in installing home-alarm systems for 33 years. "This has been the best two years," he said. "The growth of my company is almost to the point of ridiculous. It's unbelievable."
The same robust growth rate is expected for home security systems for most parts of the country for the 2001-2004 period, according to various market-intelligence reports. But there's a proviso. The residential security markets fate rides with the economy. It would be among the first consumer electronic markets to falter with an economic slowdown and a slack in new construction.
But so long as electronics prices continue to fall and the economy remains stable, demand for home security installation should keep rising - particularly in high-end residential housing developments, but also, increasingly, in middle-income and even lower-income housing developments.
GETTING A FOOT IN THE DOOR "We have two companies that perform residential installations," said Jack DeBoer, president of Turbo Electrical Contractors, Inc. and Turbo Communication Inc., Houston. "Our communications company does low-voltage wiring, alarms and such; the contracting company does all the other wiring."
DeBoer sees the security market growing for residential electrical contracting firms that can do all the power and data wiring that a homeowner wants.
"We try to offer it all and customers come to us since we can do it all. We don't have to talk or deal with two or more other contractors. And with all of the Code changes and new products coming out, homeowners and builders now depend on us to do more and more wiring."
The most profitable side of security installation is bound to be that which ties into a homeowner's PC as part of an overall structured wiring package in upscale homes. Here's where contractors have a clear advantage. First, structured wiring products need to be installed by electrical professionals. Secondly, contractors who know power and data wiring can sell security as part of a one-stop power and structured wiring package.
Knowing where to get a foot in the door is the key for contractors looking to do residential security work. In the long run, home-security manufacturers may win the home-automation race by getting electronics into many homes first. For 20 years, security companies such as ADT, have been wiring houses with a backbone of computerized motion sensors.
The wiring in essence becomes a platform to link a host of other technologies. In addition, many of these home-security system manufacturers are now updating their systems with wireless technology, which can more easily interconnect to home-automation systems and home computers.
"The smart home of the future is all about the interconnectivity of appliances," said Timothy McKinney, vice president for residential sales and marketing at ADT Security Services. "We already let you arm your house. We might as well let you check your voicemail."
Manufacturers such as ADT seem to be a natural for installing the communications wiring that connects to PC and other devices at the same time. Then again, installation of the systems is also a natural for electrical contractors, who've already laid the wiring that leads to the system in new home construction.
Also competing with electrical contractors are handy homeowners who install simple, inexpensive low-voltage security wiring systems themselves. Homeowners can buy the most popular security systems, made by X10, directly from the manufacturer.
POPULAR HOME-SECURITY PRODUCTS Most homeowners and contractors still buy home-security systems directly from the manufacturer. Distributors who specialize in home cabling, such as Great Northern Wire and Cable, GNWC (now CSC), supply only a few products.
The most popular DIY systems are manufactured by X10, Closter, N.J. The company has manufactured its home security networks, some of which cost as little as $25, for 20 years. X10's Web site - x10ideas.com - includes installation instructions to homeowners. X10 also manufactures Active Home, which integrates with personal computers allowing a homeowner to manage various security functions such as lighting and sensors through software.
Early last year, Lucent Technologies began marketing its HomeStar Wiring System, a residential high-speed wiring system, through ADT. According to ADT, this provides homebuilders with the nation's single largest buying source for residential structured cabling systems. Lucent said it will be responsible for product development and manufacturing and ADT will market, install and maintain the HomeStar through its nationwide authorized dealer network.
HomeStar allows homeowners to integrate the control and management of communication systems (phone, fax and e-mail), entertainment systems (whole-house stereo, VCR, cable, digital and satellite television), home office equipment (computers, printers and scanners) and video surveillance systems. In November 2000, Lucent took the technology one step forward when it introduced PowerHome, a software package that allows users to control home lighting and appliances as well as Home Theater's infrared devices. Lighting and appliances are controlled via X10 controllers through a CM11A or CM17A (firecracker) interface. Infrared control is achieved through the CIR (Computerized Infrared Remote) device. With this programmable interface, control is achieved via keyboard, mouse, Web, incoming X10 or voice recognition. By plugging various home devices into a built-in network like HomeStar, a resident might set a VCR with the same control used to manage the alarm system.
The best way for contractors to tap into the home-security market is knowing what their customers want - and then being able to provide it and install it.
Glen Smith told the New Hampshire Eagle-Tribune that the security-alarm trend is particularly strong in new developments.
"We're seeing a lot of electrical contractors automatically wiring a home for a security system so all that we (alarm system contractors) have to do is connect it. Houses are being prewired for alarm systems."
In the same article, Thomas Zahoruiko, a former developer-turned-construction lender, said back in the early 1990s, when the economy was struggling, it was actually a rare occasion when someone even asked him about a pre-wired alarm system.
Today, he said, security systems are practically a given in expensive, newly built homes.
"Most houses in our area are pretty expensive homes at this point, and at the bare minimum, virtually every house is wired for a security system," he said. "And even if it isn't installed, they're having it wired for an eventual security system."


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AOL just scored a major victory.
It will be selling its patent portfolio for $1.1 billion to Microsoft. Considering outsiders were valuing it at $290 million a week ago, this is quite the coup.
AOL gets a nice check from Microsoft with out legal hassles or reputational damages. Yahoo is public enemy number one in the tech world for suing Facebook over patents. A suit it could very easily lose.
However, we're scratching our heads a little bit about AOL's plans for the $1.1 billion.
In the release, AOL says, "AOL management and its Board of Directors intend to return a significant portion of the sale proceeds to shareholders and will determine the most efficient and effective method to do so prior to the closing of the transaction."
We guess it's better than plowing the money into Patch, but still, there's nothing better AOL can think of doing with its money? AOL can't come up with one area of the business to invest in? Acquisitions to make?
Even holding onto the cash for a rainy day makes more sense. It's not like AOL's core business is humming along generating cash at a fantastic clip. Its money-maker, the dial-up business, is dying and won't last forever.
If it wants to live, it's going to need that cash at some point.
Get the latest Microsoft stock price here.


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Rated 8.5 out of 10 by Game Informer.
Pro Price


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I just finished reading a wonderful article on slave housing in Montgomery County, Maryland, where one of my branches is from. A small part of the article is posted here.
I've been pondering alot lately how we need to reconsider how our enslaved ancestors lived; the physical dimensions of that space and what it said about their lives. Not long ago I posted a recommendation for a book called "Back of the Big House", and that book got me thinking about the topic much more deeply. It pains me that so many slave houses are no longer standing.
My mind, like so many others, had been imprinted with the more common images attached to the slave experience: large plantations, fields of slaves, whippings and slave cabins. My genealogy research has shown me that slavery was a dynamic institution, ever-changing, and different from farm to master to crop. There were enslaved people doing mining, and barbering, working on ships, in factories, and in stores. There were slaves hiring themselves out, and making their own money. The nature of rice farming was very different from tobacco which was different than cotton. Though whipping was common, there were other forms of punishment. We have to challenge all our assumptions about the institution. I know I did.
The slave's physical housing could speak to how much privacy (or lack thereof) they were allowed. Were 2 large families sharing a space or given separate ones? It could speak to the largess of the owner; was the housing minimal but not decrepit? How far were they spaced from the overseer's house? Many small farms housed slaves in the master's same house, in the loft space above the kitchen or other outbuildings. What did that mean for how much control the master had over their lives? Was the master boastful, setting out rows of slave cabins out front for all to see, or hiding them in back, out of immediate view of visitors?
I remember taking this picture of a slave "dormitory" at Mt. Vernon (George Washington's plantation). It had never occurred to me that slaves ever lived in anything like this.
I was equally surprised when I found pictures of stone and brick housing, duplex housing, and the myriad other forms that remove that "log cabin–field slave" image out of my mind. Yes, there were certainly log cabins, but many other types as well.
How did Malinda and her children live down in rural west Tennessee? What kind of housing did the slaveowner Nathan Cook provide in Maryland? How did they live in that space, and how did that affect the slave experience for them?
Have you searched for pictures of surviving slave housing in the area where your ancestors lived? I found only a few websites that included images of slave housing: The Missouri State Park, a dig at Monticello, and a school resource site in the UK. A promising site for Virginia doesn't seem yet to be complete.
As we tell the story of our enslaved ancestors, let's not forget the physical aspect of their day-to-day lives.
Consider this sobering description from Booker T. Washington's "Up From Slavery:"
The cabin was not only our living-place, but was also used as the kitchen for the plantation. My mother was the plantation cook. The cabin was without glass windows; it had only openings in the side which let in the light, and also the cold, chilly air of winter. There was a door to the cabin — that is, something that was called a door — but the uncertain hinges by which it was hung, and the large cracks in it, to say nothing of the fact that it was too small, made the room a very uncomfortable one. In addition to these openings there was, in the lower right-hand corner of the room, the "cat-hole," — a contrivance which almost every mansion or cabin in Virginia possessed during the ante-bellum period. The "cat-hole" was a square opening, about seven by eight inches, provided for the purpose of letting the cat pass in and out of the house at will during the night. In the case of our particular cabin I could never understand the necessity for this convenience, since there were at least a half-dozen other places in the cabin that would have accommodated the cats. There was no wooden floor in our cabin, the naked earth being used as a floor. In the centre of the earthen floor there was a large, deep opening covered with boards, which was used as a place in which to store sweet potatoes during the winter. An impression of this potato- hole is very distinctly engraved upon my memory, because I recall that during the process of putting the potatoes in or taking them out I would often come into possession of one or two, which I roasted and thoroughly enjoyed. There was no cooking-stove on our plantation, and all the cooking for the whites and slaves my mother had to do over an open fireplace, mostly in pots and "skillets." While the poorly built cabin caused us to suffer with cold in the winter, the heat from the open fireplace in summer was equally trying.


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Oct. 22, 2011
NORTH DARTMOUTH, MA-The University of Massachusetts Dartmouth's volleyball team dropped both ends of their tri-match to visiting Keene State and Clark at the Tripp Athletic Center Saturday. The Corsairs lost to Keene State, 25-20, 25-15 and 25-16, and Clark, 25-18, 23-25, 25-20, 21-25 and 15-9, while Keene State defeated Clark, 25-17, 25-16 and 25-23.
In the first match, senior middle blocker Cami Ascher (Natick, MA/Natick HS) had 10 kills, senior outside hitter Allie Mastrocola (Swansea, MA/Case HS) had eight kills, junior setter Jess Goncalves (New Bedford, MA/New Bedford HS) had 18 assists, senior libero Shannon Brodie (Chelmsford, MA/Chelmsford HS) had eight digs, and senior middle blocker Kaitlin Hogan (Tewksbury, MA/Shawsheen Tech) had four blocks.
Against the Cougars, Mastrocola had 17 kills, Hogan had 13 kills and two blocks, Goncalves had 38 assists, and Brodie had 30 digs.
"It was disappointing," said UMass Dartmouth Head Coach Steve DeRossi. "We jumped out to a lead in the first set and gave it back with some untimely hitting and serving errors. In the last set, they took the early lead and we had to play from behind the whole way. Katie Hogan had the best match of her career against Clark, and Shannon was unbelievable, she kept a lot of plays alive."
The Corsairs are now 13-14 and 1-4 in the Little East Conference. Keene State is 15-10 and 4-1 in the LEC, while Clark is 9-14. UMass Dartmouth will return to action when they visit Eastern Connecticut State Tuesday evening. Keene State will host Southern Maine Tuesday, while Clark will visit Smith Tuesday.
"We have a super tough week coming up," said DeRossi. "We still have an outside shot to make the tournament if we can win against Eastern Connecticut."


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Sunday, 18 March 2012
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ATLANTA - With one metropolitan area so much larger than the state's other cities, Georgia can't escape the influence of Atlanta, giving its mayor the opportunity to play a statewide role on par with the constitutional officers.
The mayor gets far more coverage in the metro and national media than the state's attorney general, insurance commissioner or any other constitutional officer, often more than even the governor. As the state's population continues to concentrate in metro Atlanta, where 60 percent of Georgians now live, the mayor can enjoy significant visibility.
So, it makes sense for people living outside the mammoth footprint of the Atlanta media get to know the mayor. Especially this mayor, because Mayor Kasim Reed is credited with the skill, the charm and the ambition to cash in that potential for a higher office.
Asked at a recent appearance at the Atlanta Press Club about advancing his political career, he offered the kind of coy response of a politician keeping his options open.
"I want to finish being mayor, and then I've some other plans," he said, without offering any specifics.
The 43-year-old attorney and former state legislator is running for re-election this year with $1.7 million in contributions from supporters that include the city's business and entertainment elite.
Reed claims several accomplishments. He has rid the city of its budget deficit, hired 700 police officers, reformed the pension, improved response rates for the fire department and garbage pickups, cancelled scheduled water rate increases and held property taxes steady his whole first term.
"It might not look like it, but this city is on the move," he said.
Beyond the city limits, he has been a strong advocate for deepening the shipping channel in the Savannah River to prepare the Port of Savannah to handle larger ships at low tide. He has made frequent trips to Washington to lobby his fellow Democrats, providing access that Republicans like Gov. Nathan Deal and the state's U.S. senators didn't have.
The port's potential excites him because he sees Atlanta and the whole state benefiting from the increased trade.
"People don't have any idea what we're at the beginning of with the deepening of the port," he said.
And Deal is quick to endorse his contribution.
"He has reached out. He has not only concentrated on things within his own, immediate jurisdiction, but he has been very, very helpful with us in dealing with this deepening with the Port of Savannah," the governor said. "... The reason he does this is because he recognizes it's not only good for the state, but also for the city of Atlanta."
The port lobbying has earned Reed support far beyond the metro area.
Steve Green of Savannah, chairman of the Georgia Chamber of Commerce, stood at the Press Club luncheon to praise him.
"The entire state has a debt of gratitude," said Green, the former chairman of the Georgia Ports Authority.
Reed's support for statewide initiatives isn't limited to the port. He joined Deal in campaigning for the transportation sales tax, which was eventually defeated in the Atlanta region and most of the state.
In November, Reed proposed seeking federal funding for a high-speed passenger train between Atlanta and Savannah.
"Georgia's going to have to have a number of dynamic economies, not just in the city of Atlanta but throughout the state," he said. "Savannah has all of the bones for it. It has a great personality. It has its own character."
He dreams big and he likens the rail proposal to the vision of Atlanta's longest-serving mayor, William Hartsfield, who championed what became the world's busiest airport on the city's south side.
"Who would have thought, when the leaders back then made the decision around Hartsfield-Jackson (International Airport), that we would sit here hosting 92 million passengers a year?" he asked. "The decisions around now are similar in terms of what their impact will be."
Should he run for a statewide office, like governor or U.S. Sen. Saxby Chambliss' seat that will come open next year, Reed will have challenges. Georgia hasn't elected a black man to the senate, and all the constitutional officers it picked in the last election are white Republicans.
Population trends, though, are shifting, notes Eric Tanenblatt, Mitt Romney's Georgia chairman.
"The demographics are changing if you look at the results of the presidential race," he said. "Democrats have an opportunity."
The mayor has no doubts about it.
"I think that Georgia is on an irreversible path to a Democratic majority," he said.
Reed will face opposition in some quarters for his stance for gay marriage. And he would have to overcome a broad streak of anti-Atlanta bias in many parts of the state. But with two of every three voters living in metro Atlanta, that bias may have less impact today than it did a decade ago.
Despite the obstacles, Kasim Reed is a name on the tongues of all political observers across the state. Frequent appearances on cable talk shows, his close ties to the White House, his partnership with the governor, and his success so far as a mayor all give him political stature.
That's also why he tries to stay grounded by long talks with Andy Young, a former mayor, ambassador and preacher.
"It's essential to keep me from getting too big for my britches," Reed said.
• Follow Walter Jones on Twitter @MorrisNews and Facebook or reach him at email@example.com and (404) 589-8424.


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Jim Kelly - Conservation & Environment, Sea Turtle & Coastal Conservation in Mexico
When I first arrived in Mexico, I firstly noticed the people. One thing I hadn't expected was for everyone to be so friendly. No matter how silly my questions, or how bad my Spanish, I was always met with a smile. As far as first-impressions can be trusted, I was sure of a good time ahead.
I was met promptly in Guadalajara Airport by Carlos from the Projects Abroad office which was a relief, 26 hours and I've finally found someone that speaks English! My Spanish being somewhat rusty. We went straight to my host family where I was welcomed by my host mother and introduced to the family. Soon the other volunteer who was staying with me came back from his placement and showed me around the house and told me where everything was in our part of the city.
I spent the first three weeks of my trip living the city life in Guadalajara, home of most of Mexico's projects. I was part of the Spanish language placement, where I spent a few hours each day in a private tutorial, mostly brushing up on my appalling grammar! This gave me much free time which was spent exploring the city, practicing my Spanish, socialising with the other volunteers, and anything that came to mind. There's a real sense of freedom that comes with the way the placements and accommodation are set out, you begin to feel that you aren't staying here with an organisation, more that you're living and working in the city just like anyone else.
After three weeks of enjoying myself in the city, it was time for some real work. I packed my bags and took the four hour bus journey out to Tecomán, Colima, where I would start my placement on the conservation project. I wasn't sure what to expect from the turtle camp out in the middle of nowhere, but as time went by I fell in love with it more and more each day. I've always loved the countryside, but with the nearest village or town 40 minutes away, this was the real thing. Words do no justice to the views and scenery out there, one of the most beautiful places I've ever been. I never thought I'd wake up in the morning, step outside and have a cowboy ride over to see how things are going.
Life at the camp is simple, there are set jobs to do, and once they're done, the rest of the day is yours to do with what you want. The jobs are set out on a rota, so that you only have certain jobs to do each day, but when there were only three of us there for a couple of weeks we all pitched in to get the jobs done more easily. The day begins with a 7.30am wake-up for "Camp Duty." Basically consisting of cleaning up after ourselves, the washing-up was done, and the camp generally tidied. 8am was time for the "Corral" where the turtle eggs from the night before were taken and buried in hand-made nests we made ourselves in the Corral, a protected area safe from poachers and wild animals.
Later on came "Turtle Feed", exactly what it says. There are a number of turtles kept at the camp in large pools, partly for visitors to come and see what we do, and partly because they are mostly injured and wouldn't survive back in the ocean. They feed daily either on fish, or lettuce and cucumbers. Another job was "Pool Clean." Needless to say a lot of turtles mean a lot of mess! After all this, only one job was left to do, the favourite of almost every volunteer; "Night Patrol." There are three patrols a night, two at midnight, one to the north, one to the south, and one at 3am, to the south.
These patrols consist of patrolling (evidently) along the beaches to the north and south, (16 and 12km respectively) with one of the conservation workers that also live at the camp. This takes place on the back of a quad bike, which if you're anything like me was one of the best bits, and lasts about 3-4 hours, depending on how many turtles are laying. On patrol you work together with "The Mexican Guys" as they're known, the Semarnat workers, to locate and collect recently laid turtle nests, whilst collecting information on the nest and eggs, and also the laying turtle if it's "caught in the act."
Watching a turtle lay its eggs, let alone incubating them and seeing them hatch, before watching them return into the ocean is one of the most amazing things I've ever done. It's one of those things you watch on TV at home, and think to yourself, "Wow, it'd be cool to be there." In truth, it's more than cool. I've learned more about turtles than I thought there was to know about them, and I'm left in awe at the continuing struggle of an endangered species. Coming here has taught me so much, not only in life experience, but also shown me why respect for nature is not only important, but necessary.
I'm back in the city now with only one day left before I fly home, and writing this is making me think back to my entire stay here. I've had an amazing time, which I wouldn't change now for anything. I've met some wonderful friends, both Mexican and non, I've danced the night away, and hopefully made a difference, if somewhat small, to an endangered species. I've certainly had some adventures here. Mexico has become like a second home to me now, it's a wonderful place with a most amazing and diverse culture. My only regret is that my time here is over so soon! I'm sure to return "pronto".
Finally, I hope that if you choose to come to Mexico, you'll have as wonderful a time as I have.
Jim "Jaimito"
Download videos of our Conservation Project work
|Jim collecting the hatchlings
|iPod Version
|Volunteers collecting the hatchlings
|iPod Version
|Getting ready to release the turtles
|iPod Version
|Releasing the turtles
|iPod Version
Jim Kelly
Dit verhaal is een persoonlijke ervaring van een vrijwilliger op dit project en dus een momentopname. Houd er rekening mee dat jouw ervaring hiervan af kan wijken. Onze projecten veranderen constant, omdat we inspelen op de lokale behoefte en we voortborduren op de behaalde resultaten. Ook verschillende weersomstandigheden kunnen de ervaring beïnvloeden. Lees meer over wat je kunt verwachten van dit project of neem contact met ons op voor meer informatie.


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Moderators: Three Stars, dagny, pfim, netwolf
Coy and Vance wrote::thumb: Great Job!
pcm wrote:4. Everyone's praising Vokoun's addition for this shortened season, but it seems to me that his value would be greater in a full year, when Fluery needs more rest. Am I missing something?
DelPen wrote:I have no expectations except making the playoffs this year. There are some serious questions with the coaching staff and some current players on the roster. There are also big holes that need filled hopefully by some younger players. This will, for me, be an extended camp. If some players can prove their worth and youn g guys step up then I think Shero can contrinue forward with his plan and make tweaks for next year and then with good planning 2015 will be a must win year when the cap proabbly goes down to where good teams need to scramble and make hard cuts.
If our vets continue to decline and we get no improvement in youth we will have serious problems for several years.
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Purpose: The main objective of this study was to compare the opioid use patterns, resource utilization, and costs of patients on opioid therapy who have constipation with those who do not.
Design: Retrospective, observational matched cohort design
Methodology: Patients initiating opioid therapy between Jan. 1, 1999 and Dec. 31, 2005 were identified from a longitudinal insurance claims database. Patients had ≥30 days of opioid use and continuous plan coverage for ≥6 months before and ≥12 months after their index date, defined as the date of the first pharmacy claim for an opioid.
Constipation was defined as having one or more ICD-9 codes of 564.0 during the follow-up period.
Patterns of opioid use and resource utilization were compared between patients with constipation and a demographically matched (1:1) cohort of opioid initiators without constipation using t-tests and Chi-square (∋2) tests.
Principal findings: We identified 39,485 patients, of whom 2,519 (6.4%) had constipation. Most patients with constipation were female (66%) and ≥45 years old (68%). Compared to controls, the constipation group had significantly higher rates of concurrent use of ≥2 opioids (p<0.0001), discontinuation, and switching between opioids. Patients with constipation had statistically significant higher hospital admissions, emergency room visits, home health services, nursing home care, physician office visits, other outpatient/ancillary care, and laboratory tests. Patients with constipation had significantly higher mean all-cause costs for emergency, physician visits, nursing facility, home health, and prescription drug services compared to patients without constipation.
Conclusion: Opioid-treated patients with constipation were found to have significant differences in opioid use patterns and significantly higher health care utilization and associated costs.


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No! Jason Thompson Has Announced He's Leaving General Hospital
Oct 30, 2015 9:22 PM EDT
Sadly, it appears that Dr. Drake's rounds are over on General Hospital. Jason Thompson, who has played Dr. Patrick Drake on the ABC soap for 10 years, announced the news on Instagram on Friday. "It was not an easy decision but I feel like it's time t… Read more


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We didn't get invited to LenDale White's birthday party—must have been some mixup—but thankfully all the memories of hanging out with the Tennessee Titans have been preserved forever via YouTube.
LenDale's birthday was in December, when Albert Haynesworth was still in Nashville and Vince Young was still ... whatever it was he was doing back then. After the usual shout-outs and big ups and whatnot, it's just a couple guys hanging out at the club, not getting drunk on premium water sponsorships and maybe some friendly teammate bonding.
Also, I'm not sure, but I believe Haynesworth mentions Roger Goodell "having" some girl in his office? I didn't actually catch most of that, but I do like how Albert brags about being Goodell's first "real" suspension. Suspensions must have been on his mind, because this party must have taken place about a week after the car accident that left another driver in a wheelchair, which itself was just a few days after Haynesworth had been placed on probation by judge. (Hence all the water?)
But, hey, as long as Vince keeps his shirt on, no one is going to complain.
Vince Young & Albert Haynesworth (Lendale White B-Day Party) [YouTube, via The Low Tube]


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Same issues, same faces, same hopes as Mideast peace talks resume
The old adage "familiarity breeds contempt" may apply nowhere better than the Israeli-Palestinian peace talks that are about to be reconvened after months of shuttle diplomacy by U.S. Secretary of State John Kerry. The negotiators are nothing if not familiar with one another.
From chief Israeli negotiator Tzipi Livni and chief Palestinian negotiator Saeb Erekat, down to the various deputies and experts in the room, all of the players have been involved in previous peace efforts. Even Martin Indyk, the former U.S. ambassador to Israel who Kerry named to be Washington's special envoy to usher the talks along, has been here before – during the administration of Bill Clinton, when he was the White House Middle East adviser.
It will be, as one American official described, a "meeting of old acquaintances, albeit ones that don't like or trust each other very much."
"If there are any surprises, it won't come from the players sitting around the table. We've all read each other's scripts before, we've just never reached the final act," said the American official, who has been involved in peace efforts since 2003. He spoke to McClatchy on condition of anonymity, because, he said. "We are all trying to keep big headlines out of the press before."
"Unfortunately, we are all very familiar with this process," the official said. "The optimists will tell you that having old hands back at the table gives us advantage to jump-start talks at where they last left off. The pessimists will tell you that all us old hands means no one will come with anything fresh to shake up a process that has been stalled nearly 20 years."
Since 2003, when the "roadmap for peace" established that peace between Israelis and Palestinians would be negotiated on the basis of two sovereign states, little has been done to advance that vision. Israeli officials argue that Palestinians have refused to recognize Israel as a Jewish state and that hard-line Islamists continue to advocate publicly for terrorism against Israel.
Palestinians argue that Israel continues to build settlements on land earmarked for their future state in the West Bank, and that the current Israeli leadership refuses to recognize the 1967 armistice line as the basis on which an Israeli and a Palestinian state will be drawn.
Tuesday's meeting in Washington will be the fourth effort since 2003 to restart talks, though few have made it beyond the talking-about-talking stage.
"Everyone knows what a final peace agreement will look like, we even have maps and previous working papers, and transcripts in which we can go 99 percent of the way toward establishing what a final peace treaty will look like," said one senior Palestinian official, who is taking part in the current talks and who spoke on condition of anonymity because of the sensitivity of the issue. "Nobody needs to reinvent the wheel. There is no need to stall."
Yet in statements made this week, senior Israeli and Palestinian leaders spoke of a "long road ahead" and said that they have promised to give the newest peace effort at least nine months to reach a breakthrough.
"We have to begin at the beginning. We are not going in with preconditions or preconceptions, but with a fresh starting point," said Yuval Steinitz, an Israeli Cabinet minister who is considered especially close to Israeli Prime Minister Benjamin Netanyahu. "We are not taking off where someone else left off, this is not how this is going to work."
Steinitz said that while previous Israeli leaders, including former Prime Minister Ehud Olmert, had "allegedly drawn maps and drafted agreements" during the 2007-2008 peace talks with the Palestinian leadership, none of those would be used during the new negotiations.
One senior Israeli official, also involved in the talks and therefore only willing to speak anonymously, said that Livni, a former foreign minister who's in the current government as both justice minister and peace envoy, would have to be particularly careful during negotiations and had very little "wiggle room."
"Everyone knows that she has a government behind her which doesn't really stand behind her," said the official, referring to Livni's advocacy of the two-state solution in a Cabinet that does not really back it.
"Even if she came to a final type of agreement, there is no assurances she will get it passed back home," the official said.
Israel's Cabinet voted to approve a new law that would require a public referendum on any future peace deal affecting sovereign Israeli territory. Israeli newspaper columnist Shalom Yerushalmi remarked that if that law had been in place 30 years ago, Israel never would have been able to negotiate peace with any of its neighbors.
Palestinians admit that they, too, must contend with a deeply divided public, many of whom back the position of the Hamas movement in the Gaza Strip, which opposes any negotiations.
"We all agree that neither side is enthusiastic about peace talks at this stage," said one Palestinian official previously involved in negotiations, who spoke on condition of anonymity because of the sensitivity of the issue. "Though when we go to Washington all of us will pretend to be and will talk about 'optimism' and 'prospects for peace.'"


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Avatar: The Burning Earth continues the epic adventure of Aang and his courageous fight against the evil Fire Nation in order to restore balance in his war-torn world. Based on the second season of the Avatar animated series, players will join Aang and his friends as they master their skills and fight their way to defend the greatest Earth Kingdom city against a deadly Fire Nation invasion.


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• The Schedule
Saturday, April 28, 2012 at La Rue Field
UC Santa Barbara (23-26, 8-4) vs. UC Davis (18-25, 8-4), 12 & 2 pm
All-time series record vs. Aggies: 17-5
Last time vs. UC Davis: W, 2-0 (May 14, 2011)
Live Stats
Sunday, April 29, 2012 at La Rue Field
UC Santa Barbara at UC Davis, 12 pm
Live Stats
• This Week in Gaucho Softball
UC Santa Barbara enters this weekend in a four-way tie for first-place in the Big West Conference standings. The Gauchos, this week's opponent UC Davis, Pacific, and Long Beach State are deadlocked with 8-4 league marks. UCSB will play its three-game league series against UC Davis on Saturday and Sunday at La Rue Field as both teams battle to stay atop the conference leaderboard.
• Weekend Rewind
The Gauchos snapped a six-game losing streak to Pacific last weekend as UCSB captured a Big West series two games to one. Santa Barbara used an extra inning to defeat the Tigers, 2-1, in game one before falling, 6-2, in Saturday's second game. The Gauchos were on fire in the rubber game and posted their first mercy win of the season, 11-2. Nine of the Gauchos' season-high-tying 11 runs came in the third inning.
• For The Record
The Gauchos carry a 23-26 overall record into this weekend's series with the Aggies. UCSB extended its win streak to a season-best six games on Saturday before it was snapped in game two with the Tigers. UCSB has won nine of its 12 games during the month of April.
• A Little About The Aggies
UC Davis enters this weekend's series with an 18-25 overall record and an 8-4 Big West mark. The Aggies have posted series wins over UC Riverside, Cal State Northridge and Cal Poly. Their lone series loss came to fellow first-place occupant Long Beach State. UC Davis has been led by pitcher Justine Vela, who has posted a 7-1 record in league games and a 0.40 ERA. UCSB has won its last three series against the Aggies, including a sweep of the 2011 series. Three of the last six games between the teams have extended into extra innings.
• Benefiting From Some Wisdom
There is no doubt that freshman pitcher Shelby Wisdom is having a huge rookie year. Last weekend, the hurler tied the UCSB record for single season pitcher's victories with her 18th. She is now in the elite company of Krista Cobb, Jennifer Davis and Sandy Ortigies and with nine more games on the Gauchos' slate this year, it is very likely that she will become the outright single season wins leader. Wisdom currently ranks 44th nationally in wins and is 30th in strikeouts. Her 192 strikeouts rank seventh in the UCSB single season records book. Among Big West players, she is currently first this season in innings pitched (210.2), strikeouts looking (52), appearances (41), wins and starts (28). She ranks second in strikeouts, fourth in ERA (2.56) and fifth in opponent's batting average (.257). In Big West games, Wisdom has posted an impressive 8-3 record – leading all league players in conference wins – and has compiled a 1.44 ERA. Her bat has also led the way as she has compiled a .385 average in Big West play to go along with a team-leading 10 hits, 11 RBI, .654 slugging percentage, and a .467 on-base percentage.
• DePompa And Circumstance
Senior Lainey DePompa is amidst the longest hitting streak of her career at 10 games and during that span, she has posted seven of her team-leading 20 RBI. The senior is currently batting .313 across Big West games, which is tied for second on the team with Keilani Jennings. For the season, she leads all conference players in chances (310), putouts (272) and runners caught stealing (16). Additionally, she is second in sacrifice flies (3), sixth in home runs (5) and ninth in total bases (55). She also leads the Gauchos in slugging (.417) and sacrifice hits (7).
• Moving On Up
Junior Keilani Jennings is making her mark in the UCSB career record book. She is eighth in doubles (28), tied for fifth in home runs (19) and has cracked the top-10 in RBI, now ranking 10th with 76. Jennings leads the Gauchos in doubles (9) and walks (23), ranking third in both categories in the Big West standings. The junior has reached first base safely in 18 of the last 20 games.
• Speedy Soria
Jessica Soria leads the Gauchos in hits (46), which ranks fourth in the Big West. The quick outfielder is tops among all conference players with 18 stolen bases, which ranks her ninth on the UCSB single season list, just one shy of moving into eighth. Soria has reached base safely in 16 of the last 17 games.
• Take A Pilpil
Sophomore Kathryn Pilpil has been extremely effective at getting on-base, posting a team-leading .376 on-base percentage. The second baseman has reached safely in 19 of the last 20 games, a span in which she has tallied 12 hits and 17 of her 22 walks. She is tied for first on the team in runs (21) with Soria and tied for second in hits (36). Her 22 walks rank second among the Gauchos and fourth in the league.
• Mercy Me!
Sunday's 11-2 win marked the Gauchos' first mercy win of the season and the first since they defeated Cal State Bakersfield, 11-1, on April 13, 2011. UCSB's nine-run third inning was its first since a 2010 victory over Idaho State in which the Gauchos tallied nine runs in the first inning of an eventual 11-1 victory.
• The Galicinao File
Now in her fifth season at the helm of the UCSB softball program, head coach Brie Galicinao has coached the Gauchos to a 121-138 record for a .467 winning percentage, the second best since the softball program went Division I in 1982.
• Taking On The Best
The Gauchos have played 11 games against teams in the ESPN.com/USA Softball and NFCA Top-25 polls and have played another four games against teams that were receiving votes at the time of the contest. UCSB has gone 2-9 in these games. The tough schedule is reflected in the Gauchos' ranking as No. 92 among all NCAA Division I programs in the NCAA's Rating Percentage Index. UCSB has the second-best RPI in the Big West behind Pacific, which is ranked 87th.
• Next Up: The Final Homestand
Following this week's trip to UC Davis, the Gauchos will return home for their final 2012 series at Campus Diamond against Central Coast rival, Cal Poly. The May 5-6 series will be the last in Santa Barbara for seniors Lainey DePompa, Krista Cobb, Jenny Liepman, Brooke Putich and Allison Taylor. The group will be honored prior to Sunday's series closer.


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Brazil Soccer Star Kicks Off HIV Prevention Drive Ahead of World Cup
This article was reported by GlobalPost.
GlobalPost reported that the Joint United Nations Programme on HIV/AIDS (UNAIDS) announced on April 16 that, in buildup for the World Cup, it had named Brazilian football star David Luiz as its "International Goodwill Ambassador" to help encourage fans, especially younger ones, worldwide to participate in efforts to prevent the spread of HIV. The program also intends to target discrimination toward individuals diagnosed with HIV. According to UNAIDS Chief Michel Sidibe, the appointment of Luiz could make a powerful difference, since the player's homeland is hosting the World Cup in June and "everyone's eyes will be on Brazil and David will be an inspiration both on and off the pitch." UNAIDS statistics reveal that approximately 5.4 million of the estimated 35.3 million individuals diagnosed with HIV globally are between 10-24 years of age.


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Call it a meeting of the minds.
Saturday's game between Rice and Northwestern will pit two of the top academic football programs (and schools) in the nation.
Last December, Northwestern and Rice shared the prestigious American Football Coaches Association's Academic Achievement Award. The two schools were the only in the nation with a 100-percent graduation rates for their 2003-04 football classes.
For Northwestern, it was the sixth time the Wildcats had won the award. Rice won for the first time after earning honorable mention in 21 of the previous 22 years.
"We've agreed that if it goes to overtime we'll have a spelling bee" to determine the winner, Rice coach David Bailiff joked.
• • •
Follow me on Twitter at Chronicle_Owls.


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The Nordstrom Anniversary Sale Beauty Exclusives unveiled earlier this month are almost coming to an end so I thought I should share my picks from the sale before it ends this weekend, the things I'm lusting over as we speak.
You probably know by now that Nordstrom does not have sales on beauty but what they do instead is offer fantastic values with sets from brands we all know and love. Some items are discounted (more on that below) but most are value priced, not to mention exclusive to Nordstrom for the time being.
Ready? Here we go!
Continue reading Nordstrom Anniversary Sale Beauty Exclusives 2014


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Mar 01, 2004
March 1, 2004
Poughkeepsie, NY - The Yale women's fencing team finished sixth in the three-weapon competition at the 2004 Intercollegiate Fencing Association Championships on Saturday. The Yale men's and women's teams combined to finish seventh in the six-weapon category. The Bulldog women placed seventh in the epee, fifth in the foil, and 10th in the sabre category. Alisa Mendelsohn led the way for the Elis in the individual bouts, taking sixth place overall in the foil. Carly Guss finished ninth in the sabre, while Erica Korb was ninth in the epee.


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Crude Oil Futures on a 10% Run
Crude oil is making a comeback, while natural gas is slipping.
After breaking the triple-digit mark in 2012, crude oil futures have struggled to maintain their positive momentum. The end of last year saw the fossil fuel fall at the hands of increased output and supply, as new technologies are making it easier than ever to locate and extract reserves, not to mention the prevalence of natural gas. But the last few weeks of 2012 and the beginning of this year have seen crude turn things around, as the commodity has been once again reaching for $100.
The Economic Factor
Since bottoming out in the beginning of December, crude has clawed back 10.7% of its losses while inclement weather puts a damper on the performance of natural gas. Crude's bullish performance has been based mostly on the strong economic performance seen in not only the United States but other significant markets like China. As US indexes continue to soar, an improved Chinese manufacturing sector suggests a renewed demand for oil, also helping to push this commodity higher.
Though the run has not been without its blips, like the cutting of capacity of the Seaway pipeline, it seems that crude is a safe bet for as long as major equities are able to prosper. Another hit came in the form of a supply figure, as US stockpiles in Cushing rose above 50 million barrels for the first time ever just a few weeks ago. As the glut continues to ease from supplies, crude will likely continue its run forward.
Investors will want to keep an eye on production in new shale fields like those in North Dakota, Texas, and California, as those will have the most immediate impact on futures. The overwhelming output of these regions has depressed US prices compared to those overseas. Be sure to watch for any further news surrounding the Seaway and Keystone XL pipelines, as developments there will have a swift impact on futures prices. Futures are currently contangoed through the July contract, when they fall into a period of backwardation that persists through December 2021, the furthest out these contracts are offered.
Follow us on Twitter @CommodityHQ
Editor's note: This article by Jared Cummans was originally published on Commodity HQ.
- 1
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NEW YORK/SAN ANTONIO (Reuters) - The coming weeks may well be banner ones for gun sales in America - and the massacre at a Connecticut elementary school will likely be a reason.
The appetite for guns tends to increase following a mass shooting, according to a Reuters analysis of U.S. government data on background checks run on prospective gun buyers in the past 13 years - generally regarded as a reliable indicator of whether gun sales are increasing.
Gun dealers say after such shootings some customers fear for their personal security, while others are concerned the events will spur new restrictions on gun ownership.
Figures for the first few weeks of this month are not yet available, but anecdotal evidence from nearly a dozen gun shops nationwide suggests a similar response after the deadly shooting of 20 children and six adults at the Sandy Hook school in Newtown, Connecticut, on December 14.
At the Village Gun Store in Whitefield, New Hampshire, the phone was ringing almost continuously Thursday with gun buyers calling to see if the store had any AR-15 type semiautomatic rifles, the weapon used in the massacre.
Six people were browsing the rifles that line the bare plywood walls of the store, the largest within 50 miles, and the long rows of handguns in a glass case near the cash register.
"I have a ton of rifles and guns on my wish list," said Thomas Roads, 25, a gun collector who owns seven rifles and three handguns already. He was buying accessories for a vintage black powder (muzzle-loader) handgun for a gift, but he also said the rhetoric out of Washington is "speeding up" his decisions on gun purchases.
Demand in San Antonio, Texas, appears to be just as strong.
"Yesterday was the biggest day I have had in the gun industry, and I have been in the gun industry for twenty years," Jerry McCall, owner of Texas Guns and the Texas Thunder Gun Range in San Antonio, said on Wednesday.
U.S. gun sales have grown rapidly in recent years on the back of easing state and federal restrictions, and as savvy marketing by gun manufacturers has appealed to a broader base of customers. That is reflected in the increased volume of background checks logged in the National Instant Criminal Background Check System (NICS), with November 2012 seeing a record number of queries, experts said.
Background checks are necessary for individuals buying firearms from federally licensed retailers. Actual gun sales figures are not easily trackable.
Reuters examined the number of background checks in the month of and the month after 15 mass shootings since 1999. A mass shooting was defined as an incident where at least five people were killed and where the event received sustained media attention over a period of days.
The analysis found that background checks in the month of and the month after mass shootings were on average 19 percent higher than checks in other months. The pattern holds even after 2006, when gun sales broadly started to rise.
Just this year, for example, background checks rose 17 percent in July and August, around the movie theater shooting in Aurora, Colorado, July 20 that killed 12 people and wounded 58.
To be sure, the NICS database is incomplete as it does not include many sales at gun shows, which do not always require background checks. Also, not every background check results in a sale, though the entire firearms industry uses the data as a sales proxy.
Reuters shared its findings with prominent criminologists, who said the results were consistent with their experience of how gun buying can be triggered by such events.
"People become concerned that the society is becoming more violent after the highly publicized mass shootings - as one response, they arm themselves," said Richard Rosenfeld, a professor at the University of Missouri-St. Louis and former president of the American Society of Criminology.
For Kyle Hunt, 32, a surgeon and father of two young children with a stay-at-home wife, the Sandy Hook shooting put a new urgency on protection.
"My wife and I have definitely thought in the wake of the Connecticut shooting of getting her a weapon," said Hunt, who was buying gun cleaning supplies for his hunting rifle and pistol at Bass Pro Shop Outdoor World in Brandon, Mississippi. "You should be able to have a gun to protect yourself."
That gun sales soar at a time when more people are talking about restricting ownership illustrates the deep ideological divide in America. The country enshrines the right to bear arms in its Constitution but also suffers from some of the worst gun violence in the developed world.
Events that create "anxiety-producing circumstances for gun ownership" will lead to a short-term increase in sales, said Frank Zimring, a criminologist and professor at the University of California - Berkeley Law School.
In gun shops across the country, owners said demand has been strong since the Sandy Hook shooting, particularly amid calls for tougher rules on gun ownership from President Barack Obama, New York Mayor Michael Bloomberg and other politicians.
Vice President Joe Biden on Thursday convened the first meeting of a new White House task force charged by Obama with drawing up a plan to tackle gun violence in the United States.
McCall, from the San Antonio store, said political rhetoric is behind the rush to buy.
"They want to go after the inanimate objects. That's why our sales are going through the roof, because people know that these anti-gunners have to do some sort of feel-good legislation, and they use instances like what happened in Connecticut to push their agenda, their Bloomberg agenda," McCall said.
Before the Newtown massacre, firearm industry experts said gun ownership has become more socially acceptable, particularly among groups not traditionally seen as gun buyers. Women in particular have become a rapidly growing market for gun sellers.
The annual production of rifles and shotguns for the U.S. market rose nearly 40 percent between 2002 and 2011, according to the U.S. Bureau of Alcohol, Tobacco, Firearms and Explosives. The National Shooting Sports Foundation estimates the size of the industry at roughly $4 billion a year.
Wal-Mart Stores Inc, the world's largest retailer, said in October that revenue from guns rose 76 percent in the first half of its fiscal year, while revenue from ammunition rose 30 percent.
Investors have taken note: shares of gun manufacturer Smith & Wesson Holding Corp had doubled in 2012 before the Newtown massacre, while shares of Sturm Ruger & Co Inc were up almost 48 percent.
Smith & Wesson reported in early December that its sales in the six-month period ended October 31 were up 48 percent from the same period last year.
"These data points, among others, suggest to us that firearms have now taken their place in the basket of mainstream, durable goods that consumers want to buy on Black Friday," Chief Executive James Debney said on a conference call earlier this month, referring to the traditional day-after-Thanksgiving start of the holiday shopping season.
Since Friday's shooting, gun makers' share prices have plunged and major U.S. pension funds said they were reviewing their investments in the sector.
Cerberus Capital Management LP, the private equity heavyweight, said it plans to sell Freedom Group, the top U.S. manufacture of firearms, including the AR-15-style Bushmaster, the rifle that Newtown shooter Adam Lanza used.
Recent history has shown, though, that while gun makers come under pressure in the days after a shooting, over time their growth has been uninterrupted.
For example, shares of Smith & Wesson fell in the trading sessions immediately following five major shooting incidents since January 2011, but they quickly recovered each time and are up 133 percent since then.
Smith & Wesson did not return requests for comment.
While, some large, national retailers pulled rifles like the one used at Sandy Hook Elementary off shelves in nearby stores in Connecticut, most other gun stores nationwide said they were operating as normal - with some setting records.
That was the case all week at the Hyatt Coin and Gun Shop on the west side of Charlotte, North Carolina, which has been in business since 1959 and seeing record one-day sales all week.
"They're buying it faster than we're getting it in," said owner Larry Hyatt. "After this horrible tragedy, the whole country, it scared 'em to death ... People who were thinking about buying guns in the future want to do so now."
Additional reporting by Barbara Liston in Orlando, Bill Rigby in Seattle, Emily Le Coz in Jackson, Mississippi, Martinne Geller in Danbury, Conn., Susan Heavey and David Ingram in Washington, Laura Zuckerman in Salmon, Idaho, Harriet McLeod in Charlotte, N.C., Jason McLure in New Hampshire, Siddharth Cavale and Arpita Mukherjee in Bangalore, and Janet Roberts in New York; Writing by Ben Berkowitz; Editing by Edward Tobin, Tiffany Wu and Steve Orlofsky


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Ericka knows the tallest building is in Dubai!
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