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Monday, October 23, 2006
On the Street…….Meatpacking District, New York
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46 comments
for good or bad, i think one would only ever see this in nyc…
Very Cameron Diaz. Not my cup of coffee.
Fabulous look without trying too hard.
She's very pretty and has an enviable figure, but that is a horrible outfit. It's like a model collided with a tourist.
I like her style and it's hard to pull off all of these very different pieces into a cohesive look.
c'mon! she looks fantstic!!!
She looks great in this combination, the sunnies, the shorts and the heels.
Yes, it's very Cameron Diaz and this woman pulls it off. It suits her elongated figure.
Coming from Chicago, which has decidedly entered the next season, I can't help but be envious of still being able to wear bare legs!!
Thank goodness she does not have one of those huge handbags with buckles and belts and the whole enchillada stuck to it,that shout and cry for attention.Now days first you see the huge handbags and then the person holding or hanging on to it.it's all about the right proportion, i do not think that the bag she has under her arm is.Still she does have guts to walk the macadam that way.Aha,but when one is young and beautiful as she is…one can get away with it!!
She's sorta cute but I don't see anything remarkable about the outfit.
I think we are going to be seeing lots of those little shorts cut straight like that next srping/summer, it looks to me like she got her ideas from the recent Dsquared shows where you see that look for both guys and girls. I am not sure if I like it or not.
Very nice legs, but this outfit crosses the line into bad taste. The blonde hair, the trucker skull hat, the denim cut-offs (?!?), and the obvious footwear choice don't add up. This blog features male traditional looks; I wish there were more female trad looks to enjoy in addition to the trendy looks!
She's a beautiful girl, but this would look terrible on anyone else. I hate this style of dressing, it's too close to Britney Spears for comfort!
In short, not something I could look good in or would try to pull off. I do like the shoes, but not with the outfit. She is quite brave to wear short shorts and tall wedges in NY, but most likely she lives in a "safe" part of town (i.e., one where she wouldn't get followed for wearing this– it happens).
To me this looks so LA (ok aside from the name on the shirt). Especially because it has definitely NOT been warm here for the last few days. Maybe sweater weather, sans jacket, but certainly not warm enough for little shorts. Maybe I just hate to be cold, and maybe I'm just excited about rocking my fall clothes… but to me, seasonally inappropriate clothes can either look offhandedly chic or just plain odd. I'll vote for the latter for this.
Cameron Diaz was never this cute and never had a figure like this.
It's a cute way to do casual and trendy. And it flatters her figure.
the outfit in itself is awful. she looks good simply because she's gorgeous. she could get away with anything. she also looks quite selfconfident.
comtedamour -
Los Angeles is overflowing with these girls in this outfit.
This look demands the kind of physical perfection very few real women have – if you don't have this girl's face and figure you'd look sloppy; not the least bit arresting.
Even when the clothes are casual, the Sartorialist's camera is always pointed at something chic. To me, this is not a style shot – it's a beauty shot.
Hot and Hot!
meh. she's clearly hot – what a great figure – but this outfit leaves me cold. i think it's the idea of heels with such a casual look. i give her two thumbs down.
meh. she's clearly hot – what a great figure – but this outfit leaves me cold. i think it's the idea of heels with such a casual look. i give her two thumbs down.
This does not belong on your site.
So NOT classy or even stylish in anyway.
she doesnt have a figure, a straight line is not a figure. ugly clothes
this might be a dumb question but "jeter" as in derek, right? "70″ as in…wha?? or is there another famous sports figure somewhere named jeter with the number 70?
Am I missing the reason a picture was taken of her?
What is lovely about her figure? Way too skinny…considering photos always show you 10 pounds more than your normal weight…
Clearly she looks amazing no matter what she wears. Outfit-wise I find the tomboy-ish look and high heels a little bit contrived and not as likeable as if she was wearing an old beat-up pair of converse. There is a thin line between outfits that look thoughtful/mulled-over and outfits that look contrived/calculated, I feel, and for me this one is too much the latter.
Wow. She is amazing. I love her shorts (and legs).
I'm a size 2 or 4.
Sart, please post more stylish people that are not size 0.
Also a greater mix of etnically diverse people would be cool as well,
The shoes are such an unexpected twist here. Not saying this style of shoe is rare or quirky in general, just with this particular oufit.
Her body type is clue here. This would not be easy on the average woman, maybe being that skinny is really her consciencious expresion.
Yall are crazy. I think this is a great casual look. Maybe not season appropriate, but still a fun outfit.
Although I'm not a huge fan of what she's wearing, the first word that came to my mind was "fresh." I like that she isn't following the now stale trend of tunic and leggings in subdued tones; I like the punches of color and the way she exudes with the spirit of youth in the way she openly experiments with different elements (like the gold wrist cuff paired with a baseball tee and high wedges). Different, fresh, young, great.
I love the vintage t-shirt…but the hat and the shoes are awful!!!
ushe looks like heidi klum
Eh I wouldnt wear it myself, but I like the shoes…and she has a gorgeous figure. Damn, if only i had those legs!
Looks like the model Mini Anden (by the hair & face), though who knows. I like the combo; I couldn't pull it off but I like it on her. No I don't think it's too contrived, I think it's fresh and fun. The D-squared comment seems highly likely …
look, it's paris, but with better shoes.
her bod rocks. i love everything on the outfit except the tee. it's kinda high-school-ish.
Disagree with anonymous – she's trying VERY hard. The skull and cross bones hat, the football jersey, etc. etc. All very cliched and outre. However, that does not mean 90% of the male population would find her very attractive!
Hot is right! I'm a straight woman and I can't take my eyes off of her. Wish I had her looks – those mile-long legs!
This is trying too hard. Casual with heels immediately qualifies as trying (which, of course, I can be a great thing), the skull hat makes it trying too hard.
Love the pout
Gorgeous. I see nothing bad here. Just a pretty girl with her own unique style. It works, and its hers.
Wonderful one! I like her hat and tshirt. And I did not like her bottom because of her thin legs. But general seems is nice..


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For the second year in a row, Rep. Michael McCaul has topped Roll Call's The 50 Richest Members of Congress list.
According to Roll Call, McCaul's net worth is $305.46 million.
The report notes that while McCaul was rich when he arrived on Capitol Hill, valued at around $12 million in 2005, his wealth has increased significantly in the last seven years. Part of this great increase can be attributed to his wife Linda McCaul, a daughter of Clear Channel Communications Inc. CEO, who received number of assets from her parents in 2010, quadrupling her and her husband's net worth, which went from about $73.75 million to about $294 million.
Rep. Kenny Marchant is not as lucky. His net worth dropped from $16.45 million in 2010 to $10.33 million in 2011, reports Roll Call.
Other Texas lawmakers who made it onto the top 50 list include:
Rep. Lloyd Doggett, D-Austin: valued at $8.94 million.
Rep. Blake Farenthold, R-Corpus Christi: valued at $7.56 million
Rep. Randy Neugebauer, R-Lubbock: valued at $7.1 million
Rep. Bill Flores, R-Bryan: valued at $6.94 million

subset: commoncrawl


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About Us
Who Is Teamwork Athletic?Teamwork Athletic Apparel is a leading manufacturer of team uniforms, outerwear and fan wear for 12 of the world's sports. Established in 1987, this privately-held, family-owned business employs over 200 employees in San Marcos and 150 employees in our satellite office in Mexico.
Carrying the best selection of stock styles, colors and sizes in the US, and providing our dealers with no minimums, same day shipping, in-house decoration services, and lightning fast delivery, no one comes close to the Beyond Exceptional customer service we provide daily. Catering to all levels of recreational, club, intramural, elementary/junior high/high school, and collegiate programs, Teamwork has the uniforms to get players into the game in a multitude of designs and styles that will represent each team's brand and aesthetics.
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Culture and BenefitsFrom Celebrating Our Successes to our 12 Core Values to our Busy Season Lunches to our Annual Company Rally to our Halloween Parades, Teamwork offers a friendly, casual, fast-paced and fun work environment! The dress code is casual to business casual and you can wear pretty much whatever you want as long as it is respectful to others. At the same time, we have high expectations; work very hard; and are always looking to streamline and optimize our processes.
As far as our benefits go, we offer a comprehensive benefits package including (but not limited to) medical, dental, life, paid time off (PTO), holidays, tuition reimbursement, profit sharing, and a 401(k) plan.
Teamwork is also proud of our diversity and is an Equal Employment Opportunity.
Career Opportunities
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Certain populations or groups may be targeted by criminals because of their membership in a group (such as a religion) or because of the victim's characteristics, such as age or race.
NIJ supports projects to understand and mitigate the causes and effects of crimes against specific populations. Such projects include those to estimate the prevalence of various crimes, understand offender motivation, guarantee victims' rights, and evaluate promising practices for reducing the incidence of these crimes. NIJ-supported projects also aim to understand and improve the criminal justice system's response to crimes against specific populations.
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Extent of Intimate Partner Violence
Interventions in Intimate Partner Violence
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Practical Implications of Current Domestic Violence Research (pdf, 106 pages)
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Addressing Mistreatment of Elders
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Publications on Elder Abuse
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Publications on Violence Against Women
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The Quorum
Twisted Spoon Press, 2005 - Fiction - 193 pages
Fiction. Joshua Cohen has performed in-depth investigations into mirrors and navels to return with THE QUORUM, his first collection of short fiction. A set of ten stories, a set of dreams, and a long monologue, these are all first-person rants given over by the somehow alienated individuals seeking only a sympathetic hearing, all dealing with identity and religion as well as occupied with technical ideas of reliable narration and the structure of "the mind's ear." From a review of a book about the Holocaust that's six-million blank pages to a suicide note from a young university student, from a letter home detailing an economy based on hair to a eulogy for a poem from a story narrated by three-hundred concubines to the title story about a group of people who interchange appearances, habits, proclivities and talents, THE QUORUM is a tightly-written, sensitive, and inevitably absurd take on the individual's lifelong quest to get someone, anyone, to listen.
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In the Sinnoh region, there are two Pokemon that symbolize the region. They appear in the Sinnoh reigon's myths and old folklore. One is called Dialga, and is said to have the power to control time. The other is called Palkia, who is said to have the ability to distort space. The sinister organization called Team Galaxy is trying to rule the region by utilizing these two Pokemon's power. During your adventure to complete your Pokedex and become the Champion, these two Pokemon, and Team Galaxy, will intertwine into the story and lead you on a fantastic journey across the Sinnoh region.
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This November 30, The PA Breast Cancer Coalition will join hundreds of nonprofits, organizations and businesses in Lancaster County for the Extraordinary Give.
So, what is this whole Extraordinary Give thing, anyway? It's a 24-hour online giving marathon hosted by the Lancaster County Community Foundation during which the PA Breast Cancer Coalition has an opportunity to raise thousands of dollars to support women and families in Pennsylvania. Beginning at midnight, November 30, anyone in the world can log on to ExtraGive.org, search for the PBCC and give a donation of $25 or more. During that time, the Community Foundation will choose donors for special incentives. For example, during the "Midnight Madness" hours of 12am – 3am, the Foundation will select a donor at random and throw in a little "Extra" to whichever organization that person chose to support. Click Here for more information on prizes or head to ExtraGive.org.
Find out why many PBCC supporters have chosen to donate:
Will YOU Give to the PBCC?
If you're undecided, we've chosen the Top 5 Reasons why you should consider it:
1. All of the money will stay right here in Pennsylvania. $.83 of every dollar we receive goes to support our programs and services.
2. The need is great. 32 women in Pennsylvania will be diagnosed with breast cancer TODAY and more than 12,000 will be diagnosed this year.
3. Research. Scientists and doctors in PA are breaking ground on possible new treatments every day, but they cannot continue their work without funding from nonprofits like the PBCC.
4. Advocacy. There are no questions too big or too small. The PBCC staff works to find the answers, treatments and resources for women every day.
5. Because we need to find a cure now. Each one of our programs at the PBCC supports that mission. From our Friends Like Me Care Packages to our Refunds for Research program, the PBCC relies strongly on contributions from the community to continue our work.
For 20 years, we have been fortunate to have generous donors, volunteers and Grassroots Partners. The PBCC has set an Extraordinary Give goal of $3,200 – $100 for each woman in PA diagnosed with breast cancer every day. Help us continue our mission for the next 20 years by setting aside a little "Extra" and participating in this year's Extraordinary Give on November 30!


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March 9th 1913; thirty-one-year-old writer Virginia Woolf delivers the manuscript of her first novel, The Voyage Out, to her publisher. Coincidentally, this date was also the 21st birthday of Woolf's future lover, Vita Sackville-West, who Woolf would not meet until 1925.
Woolf, born Adeline Virginia Stephen in London in 1882, grew up surrounded by intellectuals. Her father was a writer and philosopher, and her mother was a British aristocrat. In 1902, Virginia's father died, and she took a house with her sister and two brothers in the Bloomsbury district in London near the British Museum. The family developed close friendships with other intellectuals and writers, including writer E.M. Forster, economist J.M. Keyes, and biographer Lytton Strachey. Their group came to be known as the Bloomsbury Group, a leisured set known later for their intellectual and sexual nonconformism: Many of the group, including Woolf herself, were bisexual or homosexual. Woolf became a regular contributor to the Times Literary Supplement and also took odd jobs to support herself until she inherited a comfortable income from an aunt.
Virginia married writer and social reformer Leonard Woolf in 1912. The couple established the Hogarth Press in their dining room several years later. In addition to Virginia Woolf's later novels, the press also published T.S. Eliot and translations of Chekhov and Dostoevsky.
Woolf published her ground-breaking novel, Mrs Dalloway, in 1925. Its stream-of-consciousness structure deeply influenced later writers. That same year, she fell in love with poet Sackville-West, who was married to the bisexual diplomat and author Harold Nichols. The affair produced Woolf's most whimsical work, Orlando. Woolf wrote several more novels as well as social and literary criticism. However, she was given to depressive spells and battled mental illness all her life. In 1941, fearful for her own mental state and afraid of the coming World War, she filled her pockets with rocks and drowned herself.


text: "El Tarzan" Lira is an ex-convict who decides to give up his criminal past and reform his life. However, a corrupt policeman blackmails him leaving "El Tarzan" no other option but to continue committing robberies. Adapting the genre conventions of the film noir to the Mexican context, Ripstein's film focuses on Mexican police corruption and questions the judicial system.


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You won't see anime locations being remade in Minecraft often, especially not the vivid, colorful ones from Hayao Miyazaki's works. Maybe because it's not an easy task to remake something that's perfect. Yet here's Alan Becker with his Spirited Away project, ready to show us that it can be done.
One thing he did right is definitely the color palette. Check out his comparison pics below, including the Ghost Town, the Bath House or Zeniba's Cottage and you'll see:
Spirited Away in Minecraft [imgur]
Spirited Away Minecraft Recreation by Alan Becker
To contact the author of this post, write to: firstname.lastname@example.com


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A federal judge issued a preliminary injunction Monday against the state for continuing to demand the removal of a blog post that listed the home addresses of legislators who voted for California's newest gun control measures.
The lawsuit is funded by the Firearms Policy Coalition on behalf of one of the group's members, who is listed in the lawsuit under the pseudonym "Publius" and writes a blog called The Real Write Winger.
Last year, the blog published the names, home addresses and home phone numbers of 40 legislators who voted for a package of gun control measures in June, saying the lawmakers "decided to make you a criminal if you don't abide by their dictates. So below is the current tyrant registry."
Former President George W. Bush on Wednesday pushed back at the notion that his recent remarks about the media were criticisms of President Trump.
"I'm asked the question, 'Do I believe in free press?' and the answer is absolutely, I believe in free press … because the press holds people to account," he said. "Power is very addictive and it's corrosive if it becomes central to your life and therefore there needs to be an independent group of people who hold you to account. And so I answered that question and of course the headlines were, 'Bush criticizes Trump.' And so therefore I needed to say, 'There should be a free and independent press, but it ought to be accurate.'"
Bush made the remarks at the Reagan Presidential Library in Simi Valley during an hourlong question-and-answer session promoting "Portraits of Courage," his new book that features his paintings of veterans. While doing media interviews about the book in recent days, he has raised eyebrows by making comments about the media, immigrants and allegations of Russian interference in the November presidential election that were widely viewed as criticisms of the new president.
The California Legislature's four top leaders accepted $60,000 in gifts last year, including sports tickets, expensive meals, golf games and travel to foreign countries, according the annual reports they were required to file Wednesday.
Senate leader Kevin de León (D-Los Angeles) accepted 60 gifts worth $24,381, the largest amount of the four lawmakers, including travel expenses to Morocco, El Salvador, Mexico and Puerto Rico.
He received $3,100 in expenses at the Pebble Beach golf resort from the Assn. of California Life and Health Insurance Cos. and the Governor's Cup Foundation in exchange for speeches. He also accepted free tickets to SeaWorld, the Monterey Bay Aquarium and a soccer game at the Rose Bowl. The gifts were topped off with a $50 cigar from the Sacramento County Labor Council.
Gov. Jerry Brown accepted 27 gifts worth about $4,500 last year, including dinners and travel expenses, a cellphone, bottles of wine and a ticket to a basketball game from the Sacramento Kings, according to his annual filing of an economic interest form.
The amount is down significantly from 2015, when Brown accepted gifts valued at $22,136, including money from the California State Protocol Foundation to attend a climate change conference in Paris.
Last year's biggest gift was $1,883 in travel expenses from his alma mater, Yale Law School, for a speech he gave at the New Haven, Conn., institution during reunion week. The event included him receiving the school's prestigious Award of Merit.
Senate Republican Leader Jean Fuller of Bakersfield has begun talking to colleagues about eventually stepping down and passing the torch to another member given that she is termed out of office next year, but so far nobody has publicly agreed to take over the job, officials say.
An attempt by the 13-member Senate Republican Caucus to discuss a possible transition Tuesday was interrupted by a fire alarm drill, so the subject was put off at least until the next weekly caucus meeting, March 7.
"[Fuller] has been calling all of us to say, 'Hey, are you interested,'" Sen. John Moorlach (R-Costa Mesa) said. "The question is, who is willing to take it and when do we do it?"
California's cap-and-trade program limped through another weak auction of pollution permits last month, according to results provided by state regulators Wednesday.
Demand for the permits, which are required to release greenhouse gas emissions into the atmosphere, has fluctuated over the last year amid questions about the program's long-term viability.
A state appeals court is expected to rule soon on whether cap and trade represents an unconstitutional tax, and lawmakers are debating whether they should ensure the program continues past 2020.
A state senator plans to amend a bill that would create a legal defense program for immigrants, making all people facing deportation in California eligible to apply for services regardless of criminal background.
Immigrant advocates and legal aid agencies have lauded the compromise, which they said would counter anti-immigrant rhetoric from the Trump administration associating illegal immigration with violent crime.
But it remains to be seen how moderate Democrats and Republicans, who have argued against using taxpayer funds to defend dangerous offenders, will accept the move.
As concerns mount over prescription drug abuse, a California legislator wants to impose a tax on addictive opioid medications and use the funds to expand prevention and rehabilitation services.
Assemblyman Kevin McCarty (D-Sacramento) has introduced a bill that would impose a one-cent-per-milligram surcharge on prescription opioids sold in California. The tax would be imposed on wholesalers who import the medication into the state, not at the point of sale, and it would require a two-thirds approval vote in the Legislature.
"California's opioid epidemic has cost state taxpayers millions and the lives of too many of our sons and daughters," McCarty said in a statement. "We must do more to help these individuals find hope and sobriety. This plan will provide counties with critical resources needed to curb the deadly cycle of opioid and heroin addiction in California."
California Atty. Gen. Xavier Becerra said Wednesday that he is setting up an office in Washington, an unusual move for a state attorney general. Opening the new office is reflective of the fact that much of his attention will be devoted to Trump administration actions that might conflict with California policies, Becerra said.
Becerra, who has already filed three amicus briefings in lawsuits challenging Trump immigration orders, said the office will help him collaborate with members of California's congressional delegation on policies that affect the Golden State.
"Decisions that are going to affect California are going to be played out in Washington, D.C., and I think it's important for my office to have a presence here," Becerra said.


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US: The Finish Line ties up Nike ad campaign
Athletic retailer The Finish Line launched a new marketing campaign with Nike to be launched simultaneously in nearly 700 Finish Line stores.
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text: The sandgrouse's skeleton is dominated by the large, triangular keel to the breastbone, resembling the sail of a yacht. Although its proportions are accentuated by the birds' small head and diminutive tarsi and toes, this bone, whose function it is to support the substantial bulk of flight muscles, is the key to sandgrouse success. Strong, fast, and direct flight, sustainable over considerable distances, enables sandgrouse to commute. They can live "out of town," in arid regions, where the seeds that form their diet are plentiful, free from the competition and risk of predation associated with water-rich areas, by simply making daily trips to waterholes to drink. Each species has its own particular time slot at the water hole. During these flights, sometimes exceeding a hundred miles in a round-trip, they call noisily to one another, attracting birds to join them to gain safety in numbers. Sandgrouse have even been known to out-fly hunting falcons. Pictured at right: Pallas's Sandgrouse.


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College graduates' average debt recently reached an all-time high of $26,000.
But that's nothing compared to the crushing burden facing 2012 law school graduates, who had a median starting salary of $60,000 and debt loads as high as $153,000.
Since there's no way many law grads could conceivably ever pay that debt off, the feds will let grads off the hook eventually as long as they make regular payments.
But the program has serious strings attached, law professor Paul Campos points out in the current issue of the National Jurist.
Under the feds' income-based repayment program, relatively low-income grads can make small payments and have their debt forgiven after 25 years.
But grads who pay less than the full interest they owe each month will see their debt become bigger and bigger before it's eventually forgiven, Campos points out.
That huge, unsecured debt will seriously ding their credit scores.
When the government finally sets grads free after 25 years, the IRS will treat the amount as taxable income ... Like they made, say, an extra $300,000 in one year.
SEE ALSO: Harvard Law Tweeted These Yearbook Photos Of Obama And Romney >


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Jan. 26, 2012
NORTH DARTMOUTH, MA-The University of Massachusetts Dartmouth's women's basketball team used 22-6 run early in the second half to take a commanding lead and held off visiting Salem State, 85-72, in a non-conference game at the Tripp Athletic Center Thursday evening.
With the teams tied t 36-36, sophomore forward Erika Bornemann (Canton, MA/Canton HS) drained a three-pointer from the top of the key that gave UMass Dartmouth the lead for good. Junior guard Sandra Lanier (Groton, MA/Groton-Dunstable HS) hit a jump shot to cut UMD's lead to one, but freshman guard Kelsey Garrity (Somerville, MA/Somerville HS) replied with another three-pointer, junior forward Colleen Moriarty (Canton, MA/Canton HS) hit a free throw and then added a layup, Bornemann hit a trey, then Garrity, Bornemann and junior Shannon Singletary (Brockton, MA/Brockton HS) hit consecutive layups before Garrity capped the run with a three-point play.
The Vikings staged a late rally, getting layups from freshman guard Rachael Carter (Merrimack, NH/Merrimack HS) and senior guard Tara Driscoll (Swampscott, MA/Swampscott HS) to cut the UMD advantage to six points, 73-67 with 3:24 left. But Garrity followed with a layup, and the Corsairs made eight free throws during the final 2:16 to preserve their lead.
Garrity led six UMD players in double figures with a game-high 23 points. Moriarty added 17; Bornemann had 15, and junior guard Erica Batchelder (Stoughton, MA/Stoughton HS/Salem State), senior guard Stephanie Houtman (New Bedford, MA/New Bedford HS/Bridgewater State) and Singletary each scored 10. Carter led SSU with 18 points, and junior guard Breanna Comeau (Amesbury, MA/Amesbury HS) added 11. Garrity had 10 rebounds for a double double as UMass Dartmouth outrebounded Salem State, 53-46. Comeau had seven rebounds for the Vikings, who were held to 34.8 per cent from the field in the second half while the Corsairs made 58.1 per cent from the field after intermission.
"I'm very pleased that we came out with fire in the second half," said UMass Dartmouth Head Coach Amanda Van Voorhis. "We shot well from the beginning of the second half, and that helped us pull away. We were able to get some easy buckets, and we weathered their push at the end. For the most part, we did a nice job keeping our composure and pulling out a nice win. It was nice to have six players in double figures, and some people did a nice job off the bench in critical situations."
The Corsairs improved to 11-7 with the victory, while the Vikings dropped to 9-10 with the defeat. UMass Dartmouth will return to action when they visit Plymouth State Saturday. Salem State will host Westfield State Saturday.


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Teen Talk
About Us
When Your Child Wants to Die
Tracy Anglada
10 Jun, 2019
Knowing When to Let Go
Think of helping your child with bipolar disorder. What comes to mind? Advocacy? Medical treatment? Education? Intervention? Support? Therapy? Probably all of the above and rightly so. If you have raised a child with bipolar disorder, you have likely been neck deep in helping with these areas for years. But sometimes helping comes in a different form, the hardest form ever, and that is letting go. I recently had the opportunity to preview a new book on bipolar disorder called Owning Bipolar by
Back to School with Bipolar Disorder
Many children have already headed back to school – that place educator's call fun but occasionally think of as jail and kids call jail but occasionally think of as fun. As our kids walk into their classrooms each day, they carry much more than backpacks and pencils. They bring their amazing talents, gifts, personalities, hopes and dreams … and yes, their diagnoses. How can you help them shine despite their challenges? Here are some tips to help your child with bipolar disorder have a good
Knowing What You Know
You know your child. You even know that you know your child. Why? Because- you have years of experience in caring for this little life. No matter how sure you are in this knowledge, however, there may be times when someone makes you doubt what you know to be true. Maybe it's a medical professional, a family member, a teacher or even a close friend. Why does this doubt creep in? Sometimes it's because we trust the person who is questioning what we know. There is nothing wrong with considering


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The French-Canadian lark "Starbuck" has nothing to do with caffe lattes. It's a charming, albeit preposterous, tale about a 42-year-old meat delivery guy who wakes up one day to discover that he has fathered 533 children.
Its comedy is over-caffeinated, but the French-Canadian lark "Starbuck" has nothing to do with caffe lattes. It's more interested in an entirely different kind of liquid. The sort that comes in handy when making babies. And to make a story about semen see-worthy you better be fertile in clever ideas, which writer-director Ken Scott most definitely is in telling a charming, albeit preposterous, tale about a 42-year-old meat delivery guy who wakes up one day to discover that he has fathered 533 children. Wait, make that 534. Turns out his long-suffering girlfriend is also in a family way. What's the world's most prolific sperm donor to do?
Well, if you excuse the expression, he goes whacky. And bushy-haired Canadian comedian Patrick Huard is just the guy to do it. He's nothing short of a delight as the befuddled David Wozniak, or as he's better known down at the Montreal fertility clinic, Starbuck. Between 1988 and 1990, he made nearly 600 visits to the clinic, earning $40 a pop. But now, thanks to a class action suit by 142 of his "children," he's the one about to pay the price, especially if the press ever learns he is the mysterious Starbuck, the "pervert" David's coworkers fondly refer to as "El Masturbator." Not only would he become the laughing stock of the meat packing industry, it also would seriously hamper his attempts at winning back Valerie (Julie Le Breton), the beautiful – and pregnant – cop who recently dumped him for being irresponsible.
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Yes, the film reeks of contrivances, but what starts out as a broad, sometimes crude, comedy gradually evolves into a surprisingly moving ode to the joys and pains of parenthood, as David predictably progresses from perpetual goof-up into heroic father figure. The script by Scott and his partner, Martin Petit, is rich in emotion, particularly when David begins secretly paying visits to the lawsuit's complainants, never telling them who he is, but basking in the pride of what his offspring – now in their teens and 20s – have made of themselves. Suddenly, the man who never saw himself as a father can't get enough of being with his kids.
It's in these scenes that "Starbuck" is at its most genuine, filling you with warmth and affection for David and the handful of youngsters he encounters, particularly a boy born with a mental handicap. But Scott too often undercuts it with unnecessary clutter and lame jokes, most of them courtesy of roly-poly Antoine Bertrand as David's BFF and lawyer, who repeatedly attempts to convince his client that fatherhood isn't all that it's cut out to be. Bertrand may have picked up a Genie nomination (Canada's equivalent of the Oscar) for his work in "Starbuck," but I found him to be too grating and emotive for what is otherwise a comedy very much rooted in realism. Well, as real as a movie about fathering 534 kids could possibly be.
You'd much rather see the time invested in Bertrand's zany antics allotted to Le Breton, terrific as the oft-jilted partner of a man she really wants to believe in but can't. Her scenes with Huard in which they express their worst fears and greatest hopes are simply the best moments in the movie. And the chemistry they share is – true to the film's theme – potent. I'll even bet the $80,000 David owes in gambling debts that Vince Vaughn and Cobie Smulders won't be nearly half as strong in the Hollywood remake of "Starbuck," rechristened "The Deliver Man." I'll double that wager when I say Vaughn won't have the chops to match Huard in expressing the compassion and regret David encounters on his journey to fatherhood. Like they say in the sperm-donation business, it's all in the genes, and Huard possesses the ideal DNA to breed "Starbuck" into quite a stud.
STARBUCK (R for sexual content, language and some drug material.) Cast includes Patrick Huard, Julie Le Breton and Antoine Bertrand. Co-written and directed by Ken Scott. (In French with English subtitles.) At Kendall Square, Cambridge. Grade: B


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Radical Mycology
Radical Mycology
by Peter McCoy
There's a fungus among-us...in the form of Radical Mycology zine! This zine is a mushroom primer, focused mostly on the Pacific Northwest, and contains a wild mushroom identification guide. This is a good time to point out that you should be very careful with wild edibles always! And you should not eat anything you can't positively ID!! Moving on, this zine is a hefty one. Besides profiles on 11 different mushrooms, it contains info on medicinals, cultivation, making mushroom dyes and paper, bioremediation using mushrooms, and a little history on psilocybin-containing mushrooms. There are even mushroom jokes. This zine is really well put together.


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TELL CITY – Kindergarten enrollment for the Tell City-Troy Township School Corp. will be held March 10 from 1 until 6 p.m. for all children entering school for the first time. Parents and children should enter through the main door at William Tell Elementary and follow signs. Each child registering for kindergarten will be given a folder.
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text: Submitted by Anna Fader on Fri, 03/29/2013 - 3:59pm World-class museums, amazing parks and playgrounds, family-friendly neighborhoods like the Upper West Side and the Upper East Side, and tons of kid-centric services and amenities make Uptown Manhattan a fabulous place to live or visit. The American Museum of Natural History and the Children's Museum of Manhattan are perennial family favorites, but Museum Mile institutions like the Metropolitan are also great for kids and often offer free with admission family programs. Want to play outside? Central Park could keep you busy for a lifetime, but you don't want to miss all of the great playgrounds in Riverside Park. Hopefully the neighborhood guides, articles and other resources on this page will help spark your adventures. Things to DoEast Harlem Kids Neighborhood Guide Harlem Kids Neighborhood GuideInwood Kids Neighborhood GuideMidtown East Kids Neighborhood GuideMidtown West Kids Neighborhood GuideMorningside Heights Kids Neighborhood Guide 10 Kid-Friendly Things To Do on Randall's IslandRoosevelt Island: What to Do with Kids After Taking the Tram Upper East Side Kids Neighborhood GuideUpper West Side Kids Neighborhood GuideWashington Heights Kids Neighborhood GuideHidden NYC: 23 Fun Things To Do in Central Park Uptown


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As fires fade and the world falls into ruin, developer FROMSOFTWARE and director Hidetaka Miyazaki continue
their critically-acclaimed and genre-defining series with Dark Souls III. Fans and newcomers alike will get lost in
the games hallmark rewarding gameplay and immersive graphics. Now only embers remain...
Seek out the Lords of Cinder and return them to their thrones to restore flame to a decaying world of ash
Beautiful and varied environments, including my personal favorite from the entire franchise (including Bloodborne)
Intense and orchestral boss tunes, chilling screams, and terrifying enemies crawling, laughing, and clanking around shape the world around you
This is a challenging game compared to many other available titles on the market. Though the difficulty curve begins mild, be ready for that to change as you progress
An excellent entry in the fantasy series featuring unique environments, bosses, and a massive wealth of secrets and surprises
Moderately High
After a divisive second installment in the Souls series, many questions are swirling around Dark Souls III. Will players continue to be surprised as they move through beautiful environments that are as imaginative as they are deadly, or will franchise fatigue set in? Can the massive, grotesque, and intimidating bosses continue to drive fear into the hearts of players and inspire them to overcome seemingly impossible challenges through perseverance and sheer force of will? Can From Software do it again? The answer is yes, From Software and Hidetaka Miyazaki have created yet another masterful and challenging action RPG experience.
Combat depends greatly on the playstyle you choose. Whether you're playing with a heavy shield designed to take blows or dashing about and rolling, knowing your opponent's abilities and moves is as important as knowing your own. Deliberate, precise attacks - coupled with judicious defense - are the only way to victory. Failure to abide by these rules, like recklessly charging around as you would in a typical action game, invariably ends in a crushing defeat that sends you back to a bonfire - minus your payload of collected souls. Death remains a valuable learning experience for new players and veterans alike. New to Dark Souls III are weapon arts or skills, and while many weapons share the same abilities, some weapons have unique skills that are a lot of fun to play with. They don't change the core game formula much, but offer a nice new accent of flavor to combat, and are especially interesting with weapon types that didn't get as much love in prior Souls games, like bows.
Hundreds of weapons, armors, accessories, and spells are available, so you have the tools to get the job done regardless of your playstyle. You can be an archer, caster, shielded tank, two-handed brute, dual-wielding mercenary, speedy Bloodborne-style hunter (complete with items tailored to and referencing the archetype), and more. Respeccing your stat points is available from one of the NPCs you meet about a quarter through the game, so don't worry too much about making a mistake. This is a great boon if you accidentally mess up a few stat points or completely change your loadout after finding heavy armor or that perfect weapon you always wanted later on in the game.
See the rest of the review at Game Informer
If you are a fan of the Dark Souls franchise, check out all of the latest Dark Souls III games and accessories available now for Xbox One, PlayStation 4, and PC.
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PI3K Inhibitor BKM120, Carboplatin, and Pemetrexed Disodium in Treating Patients With Stage IV Non-Small Cell Lung Cancer
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT01723800
Recruitment Status : Completed
First Posted : November 8, 2012
Last Update Posted : September 20, 2016
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
|Condition or disease
|Recurrent Non-small Cell Lung Cancer Stage IV Non-small Cell Lung Cancer
|Drug: PI3K inhibitor BKM120 Drug: pemetrexed disodium Drug: carboplatin Other: laboratory biomarker analysis Other: pharmacological study Procedure: quality-of-life assessment
|Phase 1
I. To determine the recommended phase 2 dose (RP2D) of BKM120 (PI3K inhibitor BKM120) that can be administered in combination with carboplatin and pemetrexed (pemetrexed disodium) in patients with advanced non-squamous non-small cell lung cancer (NSCLC).
II. To define the dose-limiting toxicity (DLT) and other toxicities associated with the use of combination BKM120 and carboplatin and pemetrexed.
I. To evaluate the pharmacokinetic parameters of BKM120, when used in combination with carboplatin and pemetrexed.
II. To obtain preliminary evidence of anti-tumor activity with this combination.
III. To evaluate downstream inhibition of the phosphatidylinositol 3 kinase (PI3K) pathway.
OUTLINE: This is a dose-escalation study of PI3K inhibitor BKM120. Patients receive pemetrexed disodium intravenously (IV) over 10 minutes followed by carboplatin IV over 30 minutes on day 1, and PI3K inhibitor BKM120 orally (PO) once daily (QD) on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. Patients may receive courses of PI3K inhibitor BKM120 alone or PI3K inhibitor BKM120 and pemetrexed disodium after 4-6 courses with carboplatin in the absence of unacceptable toxicity or disease progression.
After completion of study treatment, patients are followed up for 28 days.
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|9 participants
|Intervention Model:
|Single Group Assignment
|None (Open Label)
|Primary Purpose:
|Official Title:
|Phase I Trial of BKM120 in Combination With Carboplatin and Pemetrexed in Patients With Advanced Non-Squamous Non-Small Cell Lung Cancer (NSCLC)
|Study Start Date :
|July 2013
|Actual Primary Completion Date :
|September 2016
|Actual Study Completion Date :
|September 2016
Experimental: Treatment (pemetrexed, carboplatin, PI3K inhibitor BKM120)
Patients receive pemetrexed disodium IV over 10 minutes followed by carboplatin IV over 30 minutes on day 1, and PI3K inhibitor BKM120 PO QD on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. Patients may receive courses of PI3K inhibitor BKM120 alone or PI3K inhibitor BKM120 and pemetrexed disodium after 4-6 courses with carboplatin in the absence of unacceptable toxicity or disease progression.
Drug: PI3K inhibitor BKM120
Given PO
Other Names:
Drug: pemetrexed disodium
Given IV
Other Names:
Drug: carboplatin
Given IV
Other Names:
Other: laboratory biomarker analysis
Correlative studies
Other: pharmacological study
Correlative studies
Other Name: pharmacological studies
Procedure: quality-of-life assessment
Ancillary studies
Other Name: quality of life assessment
- Maximum tolerated dose, defined as the highest dose in which fewer than 33% of study participants experience a dose limiting toxicity (DLT), graded according to the National Cancer Institute (NCI) CTCAE version 4.0 [ Time Frame: 21 days ]
- Toxicity profile of PI3K inhibitor BKM120, assessed using NCI CTCAE version 4.0 [ Time Frame: Up to 28 days after completion of study treatment ]Tables will be created to summarize all toxicities and side effects by dose, course, organ, and severity.
- Pharmacokinetic (PK) parameters of PI3K inhibitor BKM120, carboplatin, and pemetrexed disodium in combination [ Time Frame: Days 1 and 8 of course 1 ]Means and 95% confidence intervals will be provided for the PK parameters.
- Anti-tumor activity (complete response [CR] + partial response [PR]), assessed using RECIST [ Time Frame: Up to 28 days after completion of study treatment ]Rates and associated 95% exact Clopper and Pearson binomial confidence limits will be estimated.
- Disease control rate (CR + PR + stable disease [SD]), assessed using RECIST [ Time Frame: Up to 28 days after completion of study treatment ]Rates and associated 95% exact Clopper and Pearson binomial confidence limits will be estimated.
- Progression free survival [ Time Frame: 6 months ]Rates and associated 95% exact Clopper and Pearson binomial confidence limits will be estimated.
- Overall survival [ Time Frame: 1 year ]Rates and associated 95% exact Clopper and Pearson binomial confidence limits will be estimated.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years and older (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Patients who have signed a written informed consent
- Patients must have a histologic or cytologic diagnosis of advanced, nonsquamous NSCLC (stage IV by American Joint Committee on Cancer [AJCC] 7th edition [ed.])
- Patients should not have received prior systemic chemotherapy for metastatic disease (prior epidermal growth factor receptor [EGFR], anaplastic lymphoma kinase [ALK], kinase inhibitor therapy is allowed); prior adjuvant or neoadjuvant therapy for early stage disease is allowed if received >= 12 months prior to study entry
- Prior radiation therapy is allowed to < 25% of the bone marrow; prior radiation must be completed at least 2 weeks prior to day 1 of cycle 1, and patients must have recovered from the acute toxic effects
- Eastern Cooperative Oncology Group (ECOG) performance status =< 2
- Patients must have at least one site of measurable disease (per Response Evaluation Criteria in Solid Tumors [RECIST] 1.1)
- Absolute neutrophil count (ANC) >= 1.5 x 10^9/L
- Platelets >= 100 x 10^9/L
- Hemoglobin (Hb) > 9 g/dL
- Total calcium (corrected for serum albumin) within normal limits (bisphosphonate use for malignant hypercalcemia control is not allowed)
- Magnesium >= the lower limit of normal (LLN)
- Potassium within normal limits for the institution
- Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) within normal range (or =< 3 x upper limit of normal [ULN] if liver metastases are present)
- Serum bilirubin within normal range (or =< 1.5 x ULN if liver metastases are present)
- Serum creatinine =< 1.5 x ULN or calculated or 24-hour clearance >= 45 mL/min (calculated creatinine clearance based on Cockcroft-Gault formula)
- Serum phosphorus >= LLN
- Serum amylase =< ULN
- Serum lipase =< ULN
- Fasting plasma glucose =< 120 mg/dL (6.7 mmol/L)
- Negative serum pregnancy test within 72 hours before starting study treatment in women with childbearing potential
- International normalized ratio (INR) =< 2
Exclusion Criteria:
- Patients who have received prior treatment with a P13K inhibitor or mammalian target of rapamycin (mTOR)-directed inhibitor
- Patients with a known hypersensitivity of BKM120 or to its excipients
- Patients with anaplastic lymphoma kinase (ALK) rearrangement or an activating epidermal growth factor receptor (EGFR) mutation who have not received and progressed on appropriate tyrosine kinase inhibitor therapy
- Patients with untreated brain metastases are excluded; however, patients with metastatic central nervous system (CNS) tumors may participate in this trial, if the patient is > 2 weeks from therapy completion (incl. radiation and/or surgery), is clinically stable at the time of study entry; stable corticosteroids treatment (e.g. dexamethasone 2 mg/day, prednisolone 10 mg/day) is permitted if it was initiated at least 14 days before start of study treatment
- Patients with acute or chronic liver, renal disease or pancreatitis
Patient has any of the following mood disorders as judged by the investigator or a psychiatrist, or as a result of the patient's mood assessment questionnaire:
- Medically documented history of or active major depressive episode, bipolar disorder (I or II), obsessive-compulsive disorder, schizophrenia, a history of suicidal attempt or ideation, or homicidal ideation (immediate risk of doing harm to others) or patients with active severe personality disorders (defined according to Diagnostic and Statistical Manual of Mental Disorders [DSM]-IV) are not eligible; NOTE: for patients with psychotropic treatments ongoing at baseline, the dose and the schedule should not be modified within the previous 6 weeks prior to start of study drug
- >= Common Terminology Criteria for Adverse Events (CTCAE) grade 3 anxiety
- Meets the cut-off score of >= 10 in the Patient Health Questionnaire (PHQ)-9 or a cut-off of >= 15 in the Generalized Anxiety Disorder 7-item (GAD-7) mood scale, respectively, or selects a positive response of "1, 2, or 3" to question number 9 regarding potential for suicidal thoughts in the PHQ-9 (independent of the total score of the PHQ-9)
- Patients with diarrhea >= CTCAE grade 2
- Left ventricular ejection fraction (LVEF) < 50% as determined by echocardiogram (ECHO)
- Corrected QT interval (QTc) > 480 msec on screening electrocardiogram (ECG) (using the Fridericia correction QTc [QTcF] formula)
- Angina pectoris that requires the use of anti-anginal medication
- Ventricular arrhythmias except for benign premature ventricular contractions
- Supraventricular and nodal arrhythmias requiring a pacemaker or not controlled with medication
- Conduction abnormality requiring a pacemaker
- Valvular disease with document compromise in cardiac function
- Symptomatic pericarditis
- Myocardial infarction within the last 6 months, documented by persistent elevated cardiac enzymes or persistent regional wall abnormalities on assessment of LVEF function
- History of documented congestive heart failure (New York Heart Association functional classification III-IV)
- Documented cardiomyopathy
- Patient has poorly controlled diabetes mellitus or steroid-induced diabetes mellitus
Other concurrent severe and/or uncontrolled concomitant medical conditions (e.g., active or uncontrolled infection) that could cause unacceptable safety risks or compromise compliance with the protocol
* Significant symptomatic deterioration of lung function; if clinically indicated, pulmonary function tests including measures of predicted lung volumes, diffusion capacity of the lung for carbon monoxide (DLCO), oxygen (O2) saturation at rest on room air should be considered to exclude pneumonitis or pulmonary infiltrates
- Impairment of gastrointestinal (GI) function or GI disease that may significantly alter the absorption of BJM120 (e.g., ulcerative diseases, uncontrolled nausea, vomiting, diarrhea, malabsorption syndrome, or small bowel resection); patients with unresolved diarrhea will be excluded as previously indicated; patients must be able to swallow capsules whole
- Patients who have been treated with any hematopoietic colony-stimulating growth factors (e.g., filgrastim [G-CSF], sargramostim [GM-CSF]) =< 2 weeks prior to starting study drug; erythropoietin or darbepoetin therapy, if initiated at least 2 weeks prior to enrollment, may be continued
- Patients who are currently receiving treatment with medication with a known risk to prolong the QT interval or inducing Torsades de Pointes and the treatment cannot either be discontinued or switched to a different medication prior to starting study drug
- Patients receiving chronic treatment with steroids or another immunosuppressive agent; note: topical applications (e.g. rash), inhaled sprays (e.g. obstructive airway diseases), eye drops or local injections (e.g. intra-articular) are allowed; patients with previously treated brain metastases, who are on stable low dose corticosteroids treatment (e.g. dexamethasone 2 mg/day, prednisolone 10 mg/day) for at least 14 days before start of study treatment are eligible; premedication dexamethasone for pemetrexed is allowed
- Patients who are currently treated with drugs known to be strong inhibitors or inducers of isoenzyme cytochrome P450, family 3, subfamily A (CYP3A), and the treatment cannot be discontinued or switched to a different medication prior to starting study drug (please note that co-treatment with weak and moderate inhibitors and inducers of CYP3A is allowed)
- Herbal preparations/medication including but are not limited to St. John's wort, kava, ephedra (ma huang), gingko biloba, dehydroepiandrosterone [DHEA], yohimbe, saw palmetto, ginseng; patients should stop using these herbal medications 7 days prior to first dose of study drug
- Patients who have received systemic chemotherapy =< 4 weeks (6 weeks for nitrosourea, antibodies or mitomycin-C) and prior to starting study drug toxicities must recover to a grade 1 before starting the trial
- Patients who have received any continuous or intermittent small molecule therapeutics (excluding monoclonal antibodies) =< 5 effective half lives prior to starting study drug or who have not recovered from side effects of such therapy
- Patients who have received wide field radiotherapy =< 4 weeks or limited field radiation for palliation =< 2 weeks prior to starting study drug or who have not recovered from side effects of such therapy
- Patients who have undergone major surgery =< 2 weeks prior to starting study drug or who have not recovered from side effects of such therapy
- Patients who are currently taking therapeutic doses of warfarin sodium (Coumadin) or any other warfarin-derivative anticoagulant
Women who are pregnant or breast feeding or adults of reproductive potential not employing an effective method of birth control; double barrier contraceptives must be used through the trial by both sexes; women of child-bearing potential, defined as sexually mature women who have not undergone a hysterectomy or who have not been naturally postmenopausal for at least 12 consecutive months (i.e., who has had menses any time in the preceding 12 consecutive months), must have a negative serum pregnancy test =< 72 hours prior to initiating treatment
- Women are considered post-menopausal and not of child bearing potential if they have had 12 months of natural (spontaneous) amenorrhea with an appropriate clinical profile (e.g. age appropriate, history of vasomotor symptoms) or six months of spontaneous amenorrhea with serum follicle stimulating hormone (FSH) levels > 40 mIU/mL (for United States [US] only: and estradiol < 20 pg/mL) or have had surgical bilateral oophorectomy alone, only when the reproductive status of the woman has been confirmed by follow up hormone level assessment is she considered not of child bearing potential
- Women of child-bearing potential, defined as all women physiologically capable of becoming pregnant, must use highly effective contraception during treatment for 5 T1/2 (8 days) after stopping treatment and for additional 12 weeks (3 months in total after study drug discontinuation); the highly effective contraception is defined as either:
- True abstinence: when this is in line with the preferred and usual lifestyle of the subject; periodic abstinence (e.g., calendar, ovulation, symptothermal, post-ovulation methods) and withdrawal are not acceptable methods of contraception
- Sterilization: have had surgical bilateral oophorectomy (with or without hysterectomy) or tubal ligation at least six weeks ago; in case of oophorectomy alone, only when the reproductive status of the woman has been confirmed by follow up hormone level assessment
- Male partner sterilization (with the appropriate post-vasectomy documentation of the absence of sperm in the ejaculate); for female subjects on the study, the vasectomized male should be the sole partner for that patient
Use of a combination of any two of the following (a + b):
- a) Placement of an intrauterine device (IUD) or intrauterine system (IUS)
- b) Barrier methods of contraception: condom or occlusive cap (diaphragm or cervical/vault caps) with spermicidal foam/gel/film/cream/vaginal suppository
- Oral contraception, injected or implanted hormonal methods are not allowed
- Fertile males, defined as all males physiologically capable of conceiving offspring, must use a condom during treatment, for 5 T1/2 (8 days) after stopping treatment and for an additional 12 weeks (3 months in total after study drug discontinuation) and should not father a child in this period
- Known diagnosis of human immunodeficiency virus (HIV) infection
- History of another malignancy within 3 years, except cured basal cell carcinoma of the skin or excised carcinoma in situ of the cervix
- Patient is unable or unwilling to abide by the study protocol or cooperate fully with the investigator
- Patient has acute viral hepatitis or a history of chronic or active hepatitis B virus (HBV) or hepatitis C virus (HCV) infection, (typically defined by elevated AST/ALT [persistent or intermittent], high HBV deoxyribonucleic acid [DNA] level hepatitis B virus surface protein antigen [HBsAg] positive, or high HCV ribonucleic acid [RNA] level) (testing not mandatory)
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01723800
|United States, California
|City of Hope Medical Center
|Duarte, California, United States, 91010
|Principal Investigator:
|Karen Reckamp
|City of Hope Medical Center
|Responsible Party:
|City of Hope Medical Center
|ClinicalTrials.gov Identifier:
|NCT01723800 History of Changes
|Other Study ID Numbers:
NCI-2012-02161 ( Registry Identifier: CTRP (Clinical Trial Reporting Program) )
|First Posted:
|November 8, 2012 Key Record Dates
|Last Update Posted:
|September 20, 2016
|Last Verified:
|September 2016
Additional relevant MeSH terms:
Lung Neoplasms
Carcinoma, Non-Small-Cell Lung
Respiratory Tract Neoplasms
Thoracic Neoplasms
Neoplasms by Site
Lung Diseases
Respiratory Tract Diseases
Carcinoma, Bronchogenic
Bronchial Neoplasms
Antineoplastic Agents
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Folic Acid Antagonists
Nucleic Acid Synthesis Inhibitors


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"You pay less for fuel, get longer oil change intervals, and the engine lasts longer because propane burns much cleaner. Those savings add up fast, especially for municipalities." –Joe Allen, technical support, Rush Bus Center, a division of Rush Enterprises
Got a chance to sit down with Jacques van Heerdon and Joe Allen at Rush Truck Centers 2010 Technician Skills Rodeo this week to talk about propane-powered school buses – an appropriate topic for the two as they are, respectively, the operations manager and technical support chief for Rush Bus Centers (RBC); a division of Rush Enterprises dedicated to the school bus market.
RBC is an authorized dealer for Blue Bird school buses so it's not surprising that they were showing off not one but TWO different propane powered versions; a Vision model equipped with a GM 8.1 liter engine designed and engineered to operate on propane by Powertrain Integration using CleanFUEL USA's liquid propane injection system, with the other a smaller "Micro Bird" model built on a Ford E-450 chassis using a 6.8 liter engine powered by a Roush liquid propane system.
Why propane power for school bus fleets, you ask? Well the big reason (no surprise here) is economics; at the end of the day, using all the tax credits available, school bus fleets will typically only pay 58 to 68 cents per gallon of propane. And it takes only five minutes or so to refuel a propane bus; almost equal to the time needed for refilling a comparable diesel- or gasoline-powered model.
More importantly, perhaps, is that propane refueling stations are a lot cheaper to build versus other alternative fuels – costing some $60,000 as opposed to $180,000 to $250,000 for a comparable natural gas refilling site, for example.
Add to that an existing resupply network for liquid propane gas or "LPG" as its formally known – largely for the tanks required by gas-fired BBQ grills as well as home heating systems – and propane begins to make a lot of economic sense for school bus operators, noted RBC's Allen.
[Here, Allen shows off Blue Bird's propane-powered Vision model school bus.]
"The important part, I think, is that these buses are delivered 'propane ready' right from the factory," RBC's Allen told me. "The propane-ready engine is dropped in, the propane tanks and refueling neck are added between the frame rails, and it's ready to go – no aftermarket upfitting required."
And as school buses typically operate on short, fixed routes every day, propane's lower miles per gallon rating doesn't really affect operating patterns very much – especially as they can be refueled fairly quickly. That's one reason why San Antonio's Northside school distinct put in an order for 50 of these propane-powered yellow buses this year.
But why should truckers care? I mean, for most over-the-road operators, propane isn't a workable solution as of yet. But the critical point, I think, is this: fueling school buses with something other than diesel or gasoline makes more petroleum available to freight haulers.
Thus, removing petroleum demand from the transportation market could prove to be the biggest ripple effect of school buses switching to propane. Only time will tell, though. We'll just have to see how it all plays out.


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Murielle Melot
Manager of Performance Management
Deploying the ideal strategy to better serve customers
Réunica Group uses SAS® to manage enterprise performance strategy, be a customer-focused leader in France's social insurance economy
To enhance its track record of delivering quality social welfare services to its customers, the Réunica Group – one of France's largest health and personal insurance groups and the leader in supplementary pensions, managing EUR 8.1 billion (US$11.8 billion) in financial assets for 1.6 million pension beneficiaries – uses SAS to solidify its position as a strategic, customer-focused leader in France's social economy.
"We found early on that a strategy, no matter how good it is, delivers mediocre results if it is not implemented with the right tools," explains Murielle Melot, Manager of Performance Management. "We needed a system to remove the gap between the perspectives of senior management and operational management on a daily basis, so that our strategy could be applied at all levels of the company as part of a continuous process, and to ensure consistency between the short-term results and creation of value over the long term."
SAS allows strategic models to be refined as needed for a dynamic approach to strategy over time.
Murielle Melot
A balanced strategy
To support its enterprise-wide performance management program, Réunica used SAS to help manage all stages of its corporate initiatives, including modeling strategic maps, establishing measures to be implemented and determining performance indicators.
"We developed strategic maps based on the five principles of the balanced scorecard: financials, internal processes, customers, organizational learning and sustainable development," explains Emmanuelle Guguen, Head of Decision Support Services. "Then came the definition of a 'strategic firm', embodied by our strategic pillars – with customer service as the basis and the ambition to be a major player in the social economy at the top."
Taking action
Following the initial implementation stage, Réunica focused on aligning the organization's employees with its strategic objectives by determining action variables and performance indicators, as well as identifying departmental managers to monitor performance.
"For the objective of increasing market share, for example, the action variable is to increase the number of appointments per sales representative," explains Melot. "And the indicator is the average weekly number of appointments for each of those individuals, which is monitored by the sales manager. The definition of performance indicators and ratios is a long process and subject to debate, but it's imperative to reach a consensus."
Cause and effect
With the strategic objectives set and the departmental action variables and performance indicators in place, Réunica uses SAS to validate the cause and effect of every strategic objective and adjust, if necessary, the variables.
"Today, 400 users access the SAS solution through an online portal," says Christophe Lebert, Head of Decision Solutions at GIE Systalians, Réunica's information systems resource partner. "This new decision-making support application is completely integrated with Réunica's enterprise decision support system, covering its core areas of business – wealth, pensions, health, marketing and sales. Management uses color-coded alerts to monitor indicators and performance and can compare different historical periods, as well as drill down to see how a specific indicator was calculated."
Dynamic strategy
Réunica also uses SAS to establish correlations in the data and statistically compare the strategy models to the performance of causal chains.
"SAS allows strategic models to be refined as needed for a dynamic approach to strategy over time," concludes Melot.
Needed a solution to help implement and manage its enterprise performance strategy to attain its goal of being a customer-focused leader in France's social insurance economy.
Strategic objectives are aligned with organizational actions and performance indicators, allowing management to monitor ongoing performance and dynamically adjust strategy over time.


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816 Business
Underdog Wine a good addition to Crestwood Shops
Ari Dreshaj was a 16-year-old in his native Sicily when he first asked his mother for cooking lessons.
After moving to the U.S. in 2005, he made cooking a profession, spending the next eight years working in Italian restaurants in Dallas, Oklahoma, New York, Kansas and Missouri, all to prepare for owning his own Italian restaurant one day.
That day has come.
Dreshaj's new Luigi's Italian Restaurant opened recently at 8 E. Franklin St., in Liberty's historic downtown. Cork Brew formerly occupied the space.
"I love to cook, I love putting fresh ingredients together," said Dreshaj, who is putting in much longer hours as an owner.
His menu includes appetizers like mussels, sliced Italian sausage and Shrimp Napoleoni, along with entree salads, chicken parmigiana, and spaghetti with meat sauce. Many of the recipes are based on those his mother taught him when he was a teenager.
Customer favorites so far are the lasagna and the Shrimp Diavolo (jumbo shrimp and vegetables sauteed in a spicy, light marinara sauce over pasta).
Luigi's is open from 11 a.m. to 9 p.m. Tuesday through Saturday.
Underdog Wine opens in Crestwood
Ryan Sciara co-founded Cellar Rat Wine Merchants in the Crossroads Arts District in 2006 and made it a top draw for wine loving downtown residents and workers.
But after seven years he left the company to open a shop he could call his own.
He spent six months as a stay-at-home dad to daughters, Lola, now 5, and Luca, now 3, while working on a new wine shop concept.
In February he signed a lease for the Crestwood Shops, at 319 E. 55th St., just two blocks from his home. Underdog Wine Co., which opened in early April, specializes in wine from "underdog" vineyards.
"Not the everyday wines you see in grocery stores, chain stores. Smaller productions," Sciara said.
The 524-square-foot, long and narrow space packs in 400 different wines and 200 different spirits, along with 40 different beers and 60 different gourmet chocolate bars.
Sciara stocks wines by style or body — not by region or (grape) varietal — so the rosé wines are all together. A customer with a preference, say for a full-bodied chardonnay, may also like a viognier from the Rhône Valley.
"I want people to come in three or four times a week. To stop by on their way home and tell me what they are having for dinner so I can help pair an appropriate wine," Sciara said.
Sciara was conservative when projecting membership for his new wine club, figuring the first members would start signing up three months in. But he already has more than 100 members, up from 80 a week ago. They pay $35-and-up for two bottles a month — "interesting, seasonal ones that I don't normally stock," Sciara said.
Sciara also has built business in some unexpected ways. He put out a water bowl to be neighborly. But now when dogs stop to quench their thirst, their owners have a moment to look into the shop and consider their drink options.
Several of those dog walkers are now Underdog regulars.
After getting a dog treat from Sciara, Duke, one in a set of dachshunds, made his owner stop during the next walk as he barked at the door, seeking another.
A Crestwood resident was her group's "guinea pig," sent in to scout prices and inventory. She found Underdog's wines start at $9. But Sciara also recently sold one for $600.
Other customers like the little cards by each bottle detailing its aroma, palate, body and finish.
Country Club Plaza resident Joe Cambiano previously stopped in to check out the shop but came back last week to make a purchase.
"People in this neighborhood don't want to spend a fortune but they also want some good wines, too," he said.
It also is hosting wine tastings with California's Slo Down Wines coming in from 11:30 a.m. to 1 p.m. Saturday with their cross country 2014 Caddy Tour.
"I have a lot of new customers but I'm starting to see a lot of my old customers," Sciara said. "It's a different feeling knowing I am in control of my own destiny. When I have an idea I just do it."
Underdog Wine Co.'s hours are 10 a.m. to 7 p.m. Monday through Thursday; 10 a.m. to 8 p.m. Friday and Saturday; and 11 a.m. to 3 p.m. Sunday.


text: Wanna transform a serious room into a fun, inviting space? Looking to complete a room full of solids with a unique print? Need to add a pop of color to your dull, lackluster space? Accomplish all of the above with one simple, yet powerful home accessory we like to call the deny throw pillow! Available in four sizes, our throw pillow is made from a medium weight woven polyester with a hidden zipper and removable bun insert.


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Starting MSRP from * $96,510
Trim Recap
Contact Us
*:Dealer document processing charge of $699 not included in quoted price. Sales tax or other taxes, tag, title, registration fees, and government fees are not included in quoted price. All vehicles subject to prior sale. Accessories and color may vary. Quoted price subject to change without notice to correct errors or omissions. Estimated Monthly Payment will depend on vehicle make and model and will be determined upon actual vehicle inspection. Payment estimator calculations are for reference purposes only. All figures are estimates only and are not guaranteed as accurate. While we make every effort to ensure the data listed here is correct, there may be instances where some of the data may be listed incorrectly, please verify before purchasing. All information is gathered from sources that are believed to be reliable, but no assurance can be given that this information is complete and neither dealership nor its suppliers assume any responsibility for errors or omissions or warrant the accuracy of this information.


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- Description
- Reviews
- How Your Item Will Be Made
- About Our Birthstones
- Safe Shipping
- Easy Returns
- Jewelry Care
- Very pleased Review by Joseph
Value Uniqueness Quality
My wife was very happy to receive this ring. It's absolutely beautiful and very well made. Thank you for excellent service and a beautifully crafted product! (Posted on 12/5/2015)
- excellent Review by Jan
I am very pleased with this beautiful unique mother's ring. The service I recieved was excellent- I previewed a sample ring and was thrilled with the quality and the fast service-I can't believe they made my ring and got it to me before Mother's Day
thank you!! (Posted on 5/7/2013)
- Beautiful Ring Review by Tiffany
The ring was everything it promised to be. Beautiful and the color of the stones are fabulous. Thank you! (Posted on 6/23/2011)
Write Your Own Review
How Your Item Will Be Made
Here is a Video from Start to Finish on How Jewelry is Created by us!
Delivery & Creation From Here in the USA
Wonder why some jewelry stores online take 2-4 weeks to deliver your jewelry. This is because it's being done in China or another country and then shipped to you. All our work is done in-house by us! You can call us anytime and we will give you an update of the progress! We can even take picture of it in the making if you like!
So What's Makes This Item Different from Competitors?
Other companies use hollowed out sterling silver, gold and platinum. It saves them money and makes for a poor quality mounting. We only use heavy and solid mountings for all our jewelry. You can see the difference pictured below. Which ring do you want?
All our custom designs are created, cast, set and finished in-house by us. This is how the process works:
1) Chris Moriarty is the nephew of the owner and designs all the jewelry in our store and website. He has won numerous awards for his designs so you can be assured you are getting a very unique piece unlike anything you will see (Learn More About Chris Moriarty)
2) From there your ring is cast by Larry Moriarty, the brother of the owner. He has been a master bench jeweler for over 35 years and will make sure your ring is perfect and ready to be set (Learn More About Larry Moriarty)
3) Then the birthstones are chosen by Steve Moriarty, the owner. He has traveled the world in search of gemstones and has been cutting gemstones for over 35 years. He hand picks the gemstones for each piece. Then your ring is set by Michael Moriarty, the son of the owner. He has been setting gemstones for over 10 years now (Learn More About Steve & Michael Moriarty)
4) Then the ring is cleaned, polished and reviewed by everyone in the store before it is boxed up and shipped to you fully insured (Learn More About Everyone At Our Store)
About Our Birthstones
Our Birthstones Vs. Competitors
Other companies use simulated and imitation birthstones. We only use natural birthstones and Diamonds. Other companies use lower grade gemstones and Diamonds, which are cheaper. Each of our gemstones are of the highest quality of color and clarity, handpicked by owner and master gemcutter, Steve Moriarty.
About the Birthstones in Our Jewelry
- Quality Matters. A poor quality stone can be 1/3 the price of a natural AAA quality gemstone. We only use the highest quality gemstones.
- Natural Gemstones. Imitation and Synthetic gemstones can be 1/10 the price of natural gemstones. We only use natural gemstones.
- Diamonds. Just like Diamonds in engagement rings, the quality, cut and color matter. We use ideal cut Diamonds in white color with amazing cuts, chosen by owner, Steve Moriarty.
January: Garnet
January is garnet and we use Arizona pure chrome pyrope garnets which have a dramatic red color. Our garnets will be flawless to the naked eye and finely cut. Source: Arizona Treatment: None
February: Amethyst
February is amethyst a purple form of quartz. Each amethyst will be flawless to the naked eye and finely cut.
Source: Uraquay Treatment: Heat.
March: Aquamarine
March is aquamarine which is valued by depth of color. Ours are not the usual very light blue color but a richer medium sky blue color making them more highly valued. Our aquas are flawless to the naked eye and finely cut. Source: Madagascar or Nigeria. Treatment: Heat
April: Diamond
April is diamond and we use the top color grade which is colorless. All of our diamonds are flawless to the naked eye and have ideal cutting giving you outstanding brilliance. Our grading is F color and Si2 clarity.
Source: Unknown Treatment: None
May: Emerald
May is emerald. Although we use very fine emeralds some may show minor inclusions as only man made emeralds are flawless. Our emeralds are bright and clear and like all of our gems are natural with the finest color available. Source: Varies Treatment: Filling
June Alexandrite
June is alexandrite the rarest of all birthstones named after Czar Alexander of Russia, the original source. We are one of the few mothers ring sites to offer fine natural alexandrite. The unique character of this gem is that it changes color from green in daylight to a violet shade of red in home incandescent lighting. Viewing of the incandescent color is best in the evening when no daylight or florescent lighting is present.. If it does not have a noticable color change it cannot be called alexandrite. Due to extreme rarity some inclusions are to be expected and don't expect too strong of red color. The green is the dominant color. Because of the high cost of natural alexandrite, we have recently started offering synthetic Chatham alexandrite, the manmade gem chemically and optically identical to the natural gem. Synthetics are of higher clarity and have optimal color change. Synthetic alexandrite should not be confused with imitation alexandrite which are glass or synthetic sapphire and are of lesser value and do not represent the birthstone for June. Source: Brazil Treatment: None
July: Ruby
July is ruby which is actually the red form of sapphire both being the mineral corundum. Natural stones will have some secondary violet to pink color although our current supply is very red in color. Minor eye visible inclusions are expected.
Source: Madagascar Treatment: Heat
August: Peridot
August is peridot and our gems are a fine apple green color with fine cutting and flawless to the naked eye.
Source: Arizona and China Treatment: None
September: Sapphire
September is sapphire prized for its fine blue color although it is available in every color except red. The color is most valuable when not overly dark. It should appear blue in all lights. We use top color with fine cutting and all are flawless to the naked eye.
Source: Sri Lanka and Madagascar Treatment: Heat
October: Pink Tourmaline
October is pink tourmaline or opal. We use pink tourmaline as it is more durable and the cutting style matches the other gems that will be in the ring. Our tourmalines are a medium violet pink color with fine cutting and flawless to the naked eye.
Source: Mozambique Treatment: Heat
November: Precious Topaz
November is precious topaz. Genuine precious topaz is difficult to get and is usually a light peach to golden color. We have the natural birthstone available although we offer citrine as it generally is an accepted alternative as it is more readily available and has a more intense color which stands out better in the ring. While it is available we recommend natural precious topaz as it is the true birthstone.
Source: Brazil Treatment: Precious topaz-None Citrine-Heat
December: Blue Zircon
December is blue zircon which can be distinguished from aquamarine by its greenish blue color and a high brilliance more like a diamond. Fine cut and flawless to the naked eye. Blue topaz is often sold by some as the December birthstone as it is blue and cheap. Blue topaz is not an accepted birthstone for December. Source: Kampuchea (formerly Cambodia) Treatment: Heat
Safe Shipping
Our Safe Shipping Guarantee
We not only offer free shipping, but all purchases from us are shipped via USPS and are fully insured against loss during delivery. You must sign for your package so it will never be left on your porch or mailbox where it could be stolen or misplaced. We do also offer express shipping if you need it faster for a small charge, which is all insured and must be signed for. If you have any questions about our jewelry shipping please call us at 1-800-348-4499.
Easy Returns
Easy Returns
You have 30 days to return your item in the original condition. We will refund the amount paid minus our actual shipping cost and gift wrapping if chosen. There is a 20% restocking fee on platinum and engraved items. If you have questions, please call us at 348-4499 before returning any item.
Jewelry Care
Want to Keep your Jewelry Looking Amazing?
While Wearing Jewelry
- Remove jewelry while doing manual work or tasks. This way you won't expose your jewelry to physical damage or any chemicals.
- Don't wear jewelry while applying makeup. Hairspray, makeup and other items can expose your jewelry to damaging chemicals.
- Do not wear your jewelry in pools or hot tubs. The chemicals can cause damage to the metal and/or gemstones.
Keeping Your Jewelry Clean
- Don't wear jewelry while bathing or showering.
- Use a jewelry polishing cloth to keep your jewelry looking shiny and new.
- Clean your jewelry in jeweler-approved cleaners only.
- Use warm water to clean your jewelry.
- Do not use cleaners if your jewelry is damaged, discolored or broken.
Repairing Your Jewelry
Because we use higher quality metals and all natural gemstones, we recommend having your jewelry repaired by us or a local jeweler. If you have any concerns about jewelry purchased from us, please do not hesitate to call us at 1-800-348-4499.
How to Store Your Jewelry
- Store your jewelry in a secure place like a jewelry box where there are less chances of it hitting other items that may damage it.
- For sterling siver jewelry, place anti-tarnish strips wherever you are storing your sterling silver jewelry to prevent tarnishing.
- Always inventory your jewelry. We even recommend insuring all jewelry with your homeowners insurance or Jewelers Mutual Insurance.


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A Local Government study into two of the UK's most popular takeaway dishes has revealed 'shocking' levels of salt, sugar, colourings and fat, as well as bogus meat.
Cookery courses offered at London social enterprise bistro
PricewaterhouseCoopers has recently announced that a new social enterprise will open on the site of a former station in Tooley Street, South London. The aim of the project is to encourage disadvantaged people to develop marketable skills and find employment through a new cookery school and restaurant.
Wiltshire brewers open cookery school
Family run brewers Wadworth have launched their own cookery school in a effort to improve the standard of food across its entire business
Reduce food cravings with a protein-rich breakfast
A researcher at the University of Missouri has discovered that eating a healthy, high protein breakfast can help to reduce feelings of hunger throughout the day.
Cookery Courses: Chocolate Courses
Chocolate has been a hugely popular ingredient in the Western diet for many centuries.
Farmers welcome supermarket's sustainability plan
The National Farmers Union (NFU) has welcomed the commitment from food retailer Sainsbury's to double the amount of food it sources from Britain.
Rotherham fire station set to host cookery courses
Fire-fighters at a fire station in Rotherham have allowed a local chef from the town's catering college to use their kitchen to run a series of cookery courses aimed at local residents.
Jamie snoops on restaurant staff
Celebrity chef Jamie Oliver has installed CCTV in his restaurant kitchens in a move designed to help ensure that diners receive better quality food.
Celebrity chefs could do more to reduce food waste
A new study has revealed that the cookery styles encouraged by high profile chefs are unlikely to reduce the nation's huge amount of food waste generated by British households.
Young Carers Benefit From Cookery Courses
Young carers from the South Tyneside region have spent the summer holidays acquiring valuable skills at cookery courses arranged by the Cooking for Life project.


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Gitchell's house: Pretty as a picture
SIZE: 2836 fin. sq. ft. /1406 unfin.
ADDRESS: 1033 Locust Avenue
NEIGHBORHOOD: Locust Grove
CURB APPEAL: 8 out of a possible 10
LISTED BY: Loring Woodriff, McLean Faulconer Inc. 295-1131
People who've been around Charlottesville for a long time refer to certain houses by the names of the original owners. There are the Valentine house and Mrs. Duke's house on Park Street, the Barringer mansion on JPA, and the Carter-Gilmer House on East Jefferson, for example. This house is known to old-timers as the Gitchell house because it was the home of that famous local photographer.
But he probably wouldn't recognize it in its present incarnation. The painted clapboard of his four-over-four dwelling has been replaced with stucco, and a wing has been added to significantly enlarge the space. In addition to the basic rooms the Gitchell family enjoyed, the house now boasts a music room, a master suite and bath (replete with bidet), and decks galore.
If you had to sum up the essence of the house, though, it would not be in the elements common to houses of its vintage the standing-seam tin roof, the plaster walls, the expansive wrap-around front porch, the glowing oak and pine wood floors.
It would not even be the 20th-century upgrades: stairs leading to a nifty little attic play-space from a child's bedroom, the tile floor in the master bath, or even the stylish addition.
The aspect of this house that a 21st century buyer will relish as much as the Gitchell clan probably did is the country serenity and feeling of repose all amazingly within walking distance of the center-city.
Entering the gate of the (surprisingly rudimentary) wire and post fence, you feel as though you have been transported directly to grandma's farm. Standing in the front yard admiring the many perennials and baby boxwoods, and loomed over by oaks and magnolias, you may wonder if that sound you hear can really be chickens clucking. It is.
Out in the secluded back yard, a smallish garden and chicken coop are tucked between the house and a three-bedroom cottage and artist's studio. The space is insulated not only from Locust Avenue out front, but also from neighbors on either side. The agent reports that the several decks afford views of distant mountains in the winter, and in this lush spring, the views of varying shades of green trees as far as the eye can see are quite appealing.
More needs to be said about the cottage, which is currently, and legally, rented. It's quite spacious, with two large bedrooms, a dressing area, ample kitchen, dining area, large living room with fireplace, and full bath. If I bought this property, I'd live in the cottage and rent out the main house.
The artist's studio, mainly now a storage space, reeks of the funky mold of disuse, but it does have a full bath, pretty French doors, wide front windows, and a fireplace. These two dependencies don't have the views the larger house enjoys because of their location below the crest of Locust Avenue, but they are private and charming without them.
Because of its vintage and the appeal of the many upgrades, the property will undoubtedly find some admirers. There are a few odd elements, however, that may put off buyers who expect near perfection when they ante up $735,000. In the living room, for example, a large chunk of plaster has fallen away worrisome but rather than repair it, the owner has chosen to treat it as a "decorative element," and has placed cutesy little angels on the perimeter. Where some people glimpse heaven, however, others may see signs of costly plaster repair.
Such are the perils of buying a house almost 100 years old. But many are the charms. Combined with the lovely grounds, the latter will probably sway a well-heeled house-hunter to move into Mr. Gitchell's house and see what develops.