text:
Part I Overview Information
Department of Health and Human Services
Participating Organizations
National Institutes of Health (NIH), (http://www.nih.gov)
Components of Participating Organizations
National Institute of Mental Health (NIMH), (http://www.nimh.nih.gov)
Title: Treatment Response: Linking Genes With Behavioral Phenotypes of Relevance to Patients, Families, and Policymakers (R03)
Announcement Type
Request for
Applications (RFA) Number: RFA-MH-07-011
Catalog of Federal Domestic Assistance Number(s)
Key Dates
Release Date: March 9, 2006
Letters of Intent Receipt Date(s): April 11, 2006
Application Receipt Date(s): May 11, 2006
Peer Review Date(s): July/August 2006
Council Review Date(s): October 2006
Earliest Anticipated Start Date: December 1, 2006
Expiration Date: May 12, 2006
Due Dates for E.O. 12372
Not Applicable
Additional Overview Content
Executive Summary
This Funding Opportunity Announcement (FOA) from the National Institute of Mental Health (NIMH) calls for applications that integrate what are currently two distinct tracks of research -- determining the complex genetic basis of mental disorders, and creating new strategies and tools for assessing individual functioning in the real world. By combining these two areas of research, we aim to characterize the relationship between genetic risk and functional abilities.
Table of Contents
Part I Overview Information
Part II Full Text of Announcement
Section I. Funding Opportunity Description
1. Research Objectives
Section II. Award Information
1. Mechanism of Support
2. Funds Available
Section III. Eligibility Information
1. Eligible Applicants
A. Eligible Institutions
B. Eligible Individuals
2. Cost Sharing or Matching
3. Other - Special Eligibility Criteria
Section IV. Application and Submission Information
1. Request Application Information
2. Content and Form of Application Submission
3. Submission Dates and Times
A. Receipt and Review and Anticipated Start Dates
1. Letter of Intent
B. Sending an Application to the NIH
C. Application Processing
4. Intergovernmental Review
5. Funding Restrictions
6. Other Submission Requirements
Section V. Application Review Information
1. Criteria
2. Review and Selection Process
A. Additional Review Criteria
B. Additional Review Considerations
C. Sharing Research Data
D. Sharing Research Resources
3. Anticipated Announcement and Award Dates
Section VI. Award Administration Information
1. Award Notices
2. Administrative and National Policy Requirements
3. Reporting
Section VII. Agency Contact(s)
1. Scientific/Research Contact(s)
2. Peer Review Contact(s)
3. Financial/ Grants Management Contact(s)
Section VIII. Other Information - Required Federal Citations
Part II - Full Text of Announcement
Section I. Funding Opportunity Description
1. Research Objectives
Now that new tools (e.g., high throughput genotyping and array technology) make it possible to ask if we can determine the complex genetic basis of mental disorders, how shall we decide what are the relevant phenotypes? Articles about the genetic basis of mental illness continue to use DSM categories. Behaviors outside the realm of DSM categorization, when mentioned at all, typically only include co-morbidities such as alcohol and nicotine dependence.
The definition of mental disorders, as demarcated by the DSM, has limited meaning to someone with a mental disorder. Of more importance to the individual (and his/her family) is how the disorder affects his or her ability to live an independent, productive life on a day-to-day basis. Similarly, of more importance to policymakers is the ability to measure the public health consequences of the research funded by NIMH. Therefore, we need novel behavioral phenotypes (as opposed to, for example, psychophysiological endophenotypes) of more relevance to patients, patient's families, and policymakers.
This FOA calls for integrating what are currently two distinct tracks of research -- determining the complex genetic basis of mental disorders and creating new strategies and tools for assessing individual functioning in the real world. By combining these two areas of research, we will be able to characterize the relationship between genetic risk and functional abilities.
Currently, there is disagreement on how disorders should be demarcated when establishing genetic profiles. For example, researchers differ on whether they should look for "schizophrenia genes" or "psychosis genes"; "social phobia genes" or "anxiety genes." The hesitation in including more practical measures and endpoints in psychiatric genetics research has at least two reasons; first, it is easier to study behavior in a lab, and second, many researchers believe that rigorous measures for functioning in the real world are not available.
With this FOA, behavioral researchers are invited to team with psychiatric geneticists to investigate the links between genetic risk and practical measures of day-to-day living. As a result of this FOA, researchers may begin to look for completely different categories of genes – for example, "life-space mobility" genes (genes that are linked with getting out of the bed, or out of the house, or out of the neighborhood). This is an important daily function and relates to frequently observed detrimental behaviors among people with schizophrenia and depression (e.g., sitting all day while smoking and watching TV).
Suicide genetics research provides an example of the ways in which relevant behavioral phenotypes may emerge as a result of this initiative. Because suicide is such a noteworthy event, researchers have looked at it as a discrete category of behavior, rather than simply as a symptom of a psychopathology. Some researchers assert that genetic factors are present in risk for suicide, independent of risk for psychopathology. If researchers had only looked for genetic risk for suicide within DSM categories of depression or other psychopathologies, they would never have noticed that risk for suicide may be independent of these categories. Suicide is but one real-world behavior of considerable interest to patients and their families. Suicide is also one of the most objective measures that policy makers can look to when determining the public health impact of NIMH research.
Therefore, even though the genes for mental disorders discovered to date seem to have a small effect, we don't know if the same would be true if we looked for genes of functional behavior that is of interest to patients, their families, and policymakers. In other words, it is an empirical question whether genetic variables predict functioning independent of DSM constructs.
This FOA encourages grant applications for research in a number of critical areas including but not limited to:
See Section VIII, Other
Information - Required Federal Citations, for policies related to this
Section II. Award Information
1. Mechanism of Support
This funding opportunity will use the NIH Small Research Grant (R03) award mechanism. As an applicant, you will be solely responsible for planning, directing, and executing the proposed project. A project period of up to two years and a budget for direct costs of up to two $25,000 modules or $50,000 per year may be requested for the small grant. An R03 is not renewable.
This funding opportunity uses just-in-time concepts. It also uses the modular budget format described in the PHS 398 application instructions (see https://grants.nih.gov/grants/funding/modular/modular.htm).
2. Funds Available
The National Institute of Mental Health intends to commit approximately $1,000,000 dollars in FY 2007 to fund 2-6 new grants in response to this FOA and its related FOAs. Although the financial plans of the IC(s) provide support for this program, awards pursuant to this funding opportunity are contingent upon the availability of funds and the receipt of a sufficient number of meritorious applications.
Facilities and administrative costs requested by consortium participants are not included in the direct cost limitation, see NOT-OD-05-004.
Section III. Eligibility Information
1. Eligible Applicants
1.A. Eligible Institutions
You may submit (an) application(s) if your organization has any of the following characteristics:
1.B. Eligible Individuals
Any individual with the skills, knowledge, and resources necessary to carry out the proposed research is invited to work with their institution to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH programs.
2. Cost
Sharing or Matching
Cost sharing is not required. The most current Grants Policy Statement can be found at: https://grants.nih.gov/archive/grants/policy/nihgps_2003/index.htm#matching_or_cost_sharing.
3. Other-Special Eligibility Criteria
Not Applicable
Section IV. Application and Submission Information
1. Address
to Request Application Information
The PHS 398 application instructions are available at https://grants.nih.gov/grants/funding/phs398/phs398.html in an interactive format. Applicants must use the currently approved version of the PHS 398. For further assistance contact GrantsInfo, Telephone (301) 710-0267, Email: firstname.lastname@example.com.
Telecommunications for the hearing impaired: TTY 301-451-5936.
2. Content and Form of Application Submission
Applications must be prepared using the most current PHS 398 research grant application instructions and forms. Applications must have a D&B Data Universal Numbering System (DUNS) number as the universal identifier when applying for Federal grants or cooperative agreements. The D&B number can be obtained by calling (866) 705-5711 or through the web site at http://www.dnb.com/us/. The D&B number should be entered on line 11 of the face page of the PHS 398 form.
The title and number of this funding opportunity must be typed on line 2 of the face page of the application form and the YES box must be checked.
Foreign Organizations
Several special provisions apply to applications submitted by foreign organizations:
Proposed research should provide a unique research
opportunity not available in the U.S.
3. Submission Dates and Times
Applications must be received on or before the receipt date described below (Section IV.3.A). Submission times N/A.
3.A. Receipt, Review and Anticipated Start Dates
Letter of Intent Receipt Date(s): April 11, 2006
Application Receipt Date(s): May 11, 2006
Peer Review Date(s): July/August, 2006
Council Review Date(s): October 2006
Earliest Anticipated Start Date: December 1, 2006
3.A.1. Letter of Intent
Prospective applicants are asked to submit a letter of intent that includes the following information:
Although a letter of intent is not required, is not binding, and does not enter into the review of a subsequent application, the information that it contains allows IC staff to estimate the potential review workload and plan the review.
letter of intent is to be sent by the date listed at the beginning of this
The letter of intent should be sent to:
Donna Mayo, PhD
Division of AIDS and Health and Behavior Research
National Institute of Mental Health
6001 Executive Boulevard, Room 6228, MSC 9621
Bethesda , MD 20892
Telephone: (301) 443-1829
Email: email@example.com
3.B. Sending an Application to the NIH
Applications must be prepared using the research grant applications found in the PHS 398 instructions for preparing a research grant application. Submit a signed, typewritten original of the application, including the checklist, and three signed photocopies in one package to:
Center for Scientific Review
National Institutes of Health
6701 Rockledge Drive, Room 1040, MSC 7710
Bethesda, MD 20892-7710 (U.S. Postal Service Express or regular mail)
Bethesda, MD 20817 (for express/courier service; non-USPS service)
Personal deliveries of applications are no longer permitted (see https://grants.nih.gov/grants/guide/notice-files/NOT-OD-03-040.html).
At the time of submission, two additional copies of the application and all copies of the appendix material must be sent to:
Jean Noronha, Ph.D.
Division of Extramural Activities
National Institute of Mental Health
6001 Executive Boulevard, Room 6154, MSC 9606
Bethesda, MD 20892-9609
Rockville, MD 20852 (for express/courier service)
Using the RFA Label: The RFA label available in the PHS 398 application instructions must be affixed to the bottom of the face page of the application. Type the RFA number on the label. Failure to use this label could result in delayed processing of the application such that it may not reach the review committee in time for review. In addition, the RFA title and number must be typed on line 2 of the face page of the application form and the YES box must be marked. The RFA label is also available at: https://grants.nih.gov/grants/funding/phs398/labels.pdf.
3.C. Application Processing
Applications must be received on or before the application receipt date(s) described above (Section IV.3.A.). If an application is received after that date, it will be returned to the applicant without review. Upon receipt, applications will be evaluated for completeness by the CSR and responsiveness by the National Institute of Mental Health. Incomplete and non-responsive applications will not be reviewed. If the application is not responsive to the FOA, NIH staff may contact the applicant to determine whether to return the application to the applicant or submit it for review in competition with unsolicited applications at the next appropriate NIH review cycle.
The NIH will not accept any application in response to this funding opportunity that is essentially the same as one currently pending initial review, unless the applicant withdraws the pending application. However, when a previously unfunded application, originally submitted as an investigator-initiated application, is to be submitted in response to a funding opportunity, it is to be prepared as a NEW application. That is, the application for the funding opportunity must not include an Introduction describing the changes and improvements made, and the text must not be marked to indicate the changes from the previous unfunded version of the application.
Although there is no immediate acknowledgement of the receipt of an application, applicants are generally notified of the review and funding assignment within eight (8) weeks.
4. Intergovernmental Review
This initiative is not subject to intergovernmental review.
5. Funding Restrictions
All NIH awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Policy Statement. The Grants Policy Statement can be found at https://grants.nih.gov/grants/policy/policy.htm.
Pre-Award Costs are allowable. A grantee may, at its own risk and without NIH prior approval, incur obligations and expenditures to cover costs up to 90 days before the beginning date of the initial budget period of a new or competing continuation award if such costs: are necessary to conduct the project, and would be allowable under the grant, if awarded, without NIH prior approval. If specific expenditures would otherwise require prior approval, the grantee must obtain NIH approval before incurring the cost. NIH prior approval is required for any costs to be incurred more than 90 days before the beginning date of the initial budget period of a new or competing continuation award.
The incurrence of pre-award costs in anticipation of a competing or non-competing award imposes no obligation on NIH either to make the award or to increase the amount of the approved budget if an award is made for less than the amount anticipated and is inadequate to cover the pre-award costs incurred. NIH expects the grantee to be fully aware that pre-award costs result in borrowing against future support and that such borrowing must not impair the grantee's ability to accomplish the project objectives in the approved time frame or in any way adversely affect the conduct of the project. See NIH Grants Policy Statement https://grants.nih.gov/archive/grants/policy/nihgps_2003/index.htm.
6. Other Submission Requirements
Research Plan
The Specific Aims, Background and Significance, Preliminary Studies, and Research Design and Methods components of the Research Plan must not exceed 10 pages. All tables, graphs, figures, diagrams, and charts must be included with the 10-page limit. Be succinct and remember that there is no requirement to use all 10 pages allotted to the Research Plan.
Please note that a Progress Report is not needed.
The appendix may include graphic images of gels, micrographs, etc. provided that the image (which may be reduced in size) is also included within the 10-page limit of Items 2-5 of the Research Plan. No images may be included in the Appendix that are not also represented within the Research Plan. No publications or other printed material, with the exception of pre-printed questionnaires or surveys, may be included in the appendix.
Specific Instructions for Modular Grant applications.
Applications requesting up to $250,000 per year in direct costs must be submitted in a modular budget format. The modular budget format simplifies the preparation of the budget in these applications by limiting the level of budgetary detail. Applicants request direct costs in $25,000 modules. Section C of the research grant application instructions for the PHS 398 at https://grants.nih.gov/grants/funding/phs398/phs398.html includes step-by-step guidance for preparing modular budgets. Applicants must use the currently approved version of the PHS 398. Additional information on modular budgets is available at https://grants.nih.gov/grants/funding/modular/modular.htm.
Plan for Sharing Research Data
precise content of the data-sharing plan will vary, depending on the data being
collected and how the investigator is planning to share the data. Applicants
who are planning to share data may wish to describe briefly the expected
schedule for data sharing, the format of the final dataset, the documentation
to be provided, whether or not any analytic tools also will be provided,
whether or not a data-sharing agreement will be required and, if so, a brief
description of such an agreement (including the criteria for deciding who can
receive the data and whether or not any conditions will be placed on their
use), and the mode of data sharing (e.g., under their own auspices by mailing a
disk or posting data on their institutional or personal website, through a data
archive or enclave). Investigators choosing to share under their own auspices
may wish to enter into a data-sharing agreement. References to data sharing may
also be appropriate in other sections of the application.
Applicants requesting more than $500,000 in direct costs in any year of the proposed research must include a plan for sharing research data in their application. The funding organization will be responsible for monitoring the data sharing policy (https://grants.nih.gov/grants/policy/data_sharing).
The reasonableness of the data sharing plan or the rationale for not sharing research data may be assessed by the reviewers. However, reviewers will not factor the proposed data sharing plan into the determination of scientific merit or the priority score.
Sharing Research Resources
NIH policy requires that grant awardee recipients make unique research resources readily available for research purposes to qualified individuals within the scientific community after publication (NIH Grants Policy Statement https://grants.nih.gov/archive/archive/grants/policy/nihgps_2003/index.htm and https://grants.nih.gov/archive/grants/policy/nihgps_2003/index.htm#_Toc54600131). Investigators responding to this funding opportunity should include a plan for sharing research resources addressing how unique research resources will be shared or explain why sharing is not possible.
The adequacy of the resources sharing plan and any related data sharing plans will be considered by Program staff of the funding organization when making recommendations about funding applications. The effectiveness of the resource sharing will be evaluated as part of the administrative review of each non-competing Grant Progress Report (PHS 2590, https://grants.nih.gov/grants/funding/2590/2590.htm). See Section VI.3. Reporting.
Section V. Application Review Information
1. Criteria
The following will be considered in making funding decisions:
2. Review and Selection Process
Applications that are complete and responsive to the FOA will be evaluated for scientific and technical merit by an appropriate peer review group convened by the National Institute of Mental Health in accordance with the review criteria stated below.
As part of the initial merit review, all applications will:
The NIH R03 small grant is a mechanism for supporting discrete, well-defined projects that realistically can be completed in two years and that require limited levels of funding. Because the research plan is restricted to 10 pages, an R03 grant application will not have the same level of detail or extensive discussion found in an R01 application. Accordingly, reviewers should evaluate the conceptual framework and general approach to the problem, placing less emphasis on methodological details and certain indicators traditionally used in evaluating the scientific merit of R01 applications including supportive preliminary data. Appropriate justification for the proposed work can be provided through literature citations, data from other sources, or from investigator-generated data. Preliminary data are not required, particularly in applications proposing pilot or feasibility studies.
The goals of NIH supported research are to advance our
understanding of biological systems, to improve the control of disease, and to
enhance health. In their written critiques, reviewers will be asked to comment
on each of the following criteria in order to judge the likelihood that the
proposed research will have a substantial impact on the pursuit of these goals.
Each of these criteria will be addressed and considered in assigning the
overall score, weighting them as appropriate for each application. Note that an
application does not need to be strong in all categories to be judged likely to
have major scientific impact and thus deserve a high priority score. For
example, an investigator may propose to carry out important work that by its
nature is not innovative but is essential to move a field forward.
Significance: Does this study address an important problem? If the aims of the application are achieved, how will scientific knowledge or clinical practice be advanced? What will be the effect of these studies on the concepts, methods, technologies, treatments, services, or preventative interventions that drive this field?
Approach: Are the conceptual or
clinical framework, design, methods, and analyses adequately developed, well
integrated, well reasoned, and appropriate to the aims of the project? Does the
applicant acknowledge potential problem areas and consider alternative tactics?
Innovation: Is the project original and innovative? For example: Does the project challenge existing paradigms or clinical practice; address an innovative hypothesis or critical barrier to progress in the field? Does the project develop or employ novel concepts, approaches, methodologies, tools, or technologies for this area?
Investigators: Are the investigators appropriately trained and well suited to carry out this work? Is the work proposed appropriate to the experience level of the principal investigator and other researchers? Does the investigative team bring complementary and integrated expertise to the project (if applicable)?
Environment: Does the scientific environment in which the work will be done contribute to the probability of success? Do the proposed studies benefit from unique features of the scientific environment, or subject populations, or employ useful collaborative arrangements? Is there evidence of institutional support?
2.A. Additional Review Criteria:
In addition to the above criteria, the following items will continue to be considered in the determination of scientific merit and the priority score:
Protection of Human Subjects from Research Risk: The involvement of human subjects and protections from research risk relating to their participation in the proposed research will be assessed (see the Research Plan, Section E on Human Subjects in the PHS Form 398).
Inclusion of Women, Minorities and Children in Research: The adequacy of plans to include subjects from both genders, all racial and ethnic groups (and subgroups), and children as appropriate for the scientific goals of the research will be assessed. Plans for the recruitment and retention of subjects will also be evaluated (see the Research Plan, Section E on Human Subjects in the PHS Form 398).
2.B. Additional Review Considerations
Budget: The reasonableness of the proposed budget and the requested period of support in relation to the proposed research may be assessed by the reviewers. Is the percent effort listed for the PD/PI appropriate for the work proposed? Is each budget category realistic and justified in terms of the aims and methods? The priority score should not be affected by the evaluation of the budget.
2.C. Sharing Research Data
Not Applicable
2.D. Sharing Research Resources
NIH policy requires that grant awardee recipients make unique research resources readily available for research purposes to qualified individuals within the scientific community after publication (See the NIH Grants Policy Statement https://grants.nih.gov/archive/grants/policy/nihgps/part_ii_5.htm#availofrr and http://www.ott.nih.gov/policy/rt_guide_final.html). Investigators responding to this funding opportunity should include a sharing research resources plan addressing how unique research resources will be shared or explain why sharing is not possible.
Program staff will be responsible for the administrative review of the plan for sharing research resources.
The adequacy of the resources sharing plan will be considered by Program staff of the funding organization when making recommendations about funding applications. Program staff may negotiate modifications of the data and resource sharing plans with the awardee before recommending funding of an application. The final version of the data and resource sharing plans negotiated by both will become a condition of the award of the grant. The effectiveness of the resource sharing will be evaluated as part of the administrative review of each non-competing Grant Progress Report (PHS 2590). See Section VI.3. Reporting.
3. Anticipated Announcement and Award Dates
The earliest date that awards can be made is December 1, 2006.
Section VI. Award Administration Information
1. Award Notices
After the peer review of the application is completed, the PD/PI will be able to access his or her Review Results and Summary Statement (written critique) via the eRA Commons.
If the application is under consideration for funding,
NIH will request "just-in-time" information from the applicant. For
details, applicants may refer to the NIH Grants Policy Statement Part II: Terms
and Conditions of NIH Grant Awards, Subpart A: General (https://grants.nih.gov/archive/grants/policy/nihgps_2003/index.htm).
A formal notification in the form of a Notice of Award (NoA) will be provided to the applicant organization. The NoA signed by the grants management officer is the authorizing document. Once all administrative and programmatic issues have been resolved, the NoA will be generated via email notification from the awarding component to the grantee business official (designated in item 12 on the Application Face Page). If a grantee is not email enabled, a hard copy of the NoA will be mailed to the business official.
Selection of an application for award is not an authorization to begin performance. Any costs incurred before receipt of the NoA are at the recipient's risk. These costs may be reimbursed only to the extent considered allowable pre-award costs. See Also Section IV.5. Funding Restrictions.
2. Administrative and National Policy Requirements
All NIH grant and cooperative agreement awards include the NIH Grants Policy Statement as part of the Notice of Award. For these terms of award, see the NIH Grants Policy Statement Part II: Terms and Conditions of NIH Grant Awards, Subpart A: General (https://grants.nih.gov/archive/grants/policy/nihgps_2003/index.htm) and Part II Terms and Conditions of NIH Grant Awards, Subpart B: Terms and Conditions for Specific Types of Grants, Grantees, and Activities (https://grants.nih.gov/archive/grants/policy/nihgps_2003/index.htm).
3. Reporting
Awardees will be required to submit the PHS Non-Competing Grant Progress Report, Form 2590 annually (https://grants.nih.gov/grants/funding/2590/2590.htm) and financial statements as required in the NIH Grants Policy Statement
Section VII. Agency Contacts
We encourage your inquiries
concerning this funding opportunity and welcome the opportunity to answer
questions from potential applicants. Inquiries may fall into three areas:
scientific/research, peer review, and financial or grants management issues:
1. Scientific/Research Contacts:
Donna Mayo, PhD
Division of AIDS and Health and Behavior Research
National Institute of Mental Health
6001 Executive Boulevard, Room 6228, MSC 9621
Bethesda , MD 20892
Telephone: (301) 443-1829
Email: email@example.com
2. Peer Review Contacts:
David Armstrong, Ph.D.
Division of Extramural Activities
National Institute of Mental Health
6001 Executive Boulevard, Room 6138, MSC 9606
Bethesda, MD 20892-9606
Telephone: 301-443-3534
Email: firstname.lastname@example.com
3. Financial or Grants Management Contacts:
Rita V. Sisco
Division of Extramural Activities
National Institute of Mental Health
6001 Executive Boulevard, Room 6120, MSC 9537
Bethesda, MD 20892-9537
Telephone: (301) 443-2805
Fax: (301) 443-6885
Email: email@example.com
Section VIII. Other Information
Required Federal Citations
Human Subjects Protection:
Federal regulations (45CFR46) require that applications and proposals involving human subjects must be evaluated with reference to the risks to the subjects, the adequacy of protection against these risks, the potential benefits of the research to the subjects and others, and the importance of the knowledge gained or to be gained (http://www.hhs.gov/ohrp/humansubjects/guidance/45cfr46.htm).
Data and Safety Monitoring Plan:
Data and safety monitoring is required for all types of clinical trials, including physiologic toxicity and dose-finding studies (phase I); efficacy studies (Phase II); efficacy, effectiveness and comparative trials (Phase III). Monitoring should be commensurate with risk. The establishment of data and safety monitoring boards (DSMBs) is required for multi-site clinical trials involving interventions that entail potential risks to the participants (NIH Policy for Data and Safety Monitoring, NIH Guide for Grants and Contracts, https://grants.nih.gov/grants/guide/notice-files/not98-084.html).
Sharing Research Data:
Investigators submitting an NIH application seeking $500,000 or more in direct costs in any single year are expected to include a plan for data sharing or state why this is not possible (https://grants.nih.gov/grants/policy/data_sharing).
Investigators should seek guidance from their institutions, on issues related to institutional policies and local IRB rules, as well as local, State and Federal laws and regulations, including the Privacy Rule. Reviewers will consider the data sharing plan but will not factor the plan into the determination of the scientific merit or the priority score.
Access to Research Data through the Freedom of Information Act:
The Office of Management and Budget (OMB) Circular A-110 has been revised to provide access to research data through the Freedom of Information Act (FOIA) under some circumstances. Data that are (1) first produced in a project that is supported in whole or in part with Federal funds and (2) cited publicly and officially by a Federal agency in support of an action that has the force and effect of law (i.e., a regulation) may be accessed through FOIA. It is important for applicants to understand the basic scope of this amendment. NIH has provided guidance at https://grants.nih.gov/grants/policy/a110/a110_guidance_dec1999.htm. Applicants may wish to place data collected under this funding opportunity in a public archive, which can provide protections for the data and manage the distribution for an indefinite period of time. If so, the application should include a description of the archiving plan in the study design and include information about this in the budget justification section of the application. In addition, applicants should think about how to structure informed consent statements and other human subjects procedures given the potential for wider use of data collected under this award.
Inclusion of Women And Minorities in Clinical Research:
It is the policy of the NIH that women and members of minority groups and their sub-populations must be included in all NIH-supported clinical research projects unless a clear and compelling justification is provided indicating that inclusion is inappropriate with respect to the health of the subjects or the purpose of the research. This policy results from the NIH Revitalization Act of 1993 (Section 492B of Public Law 103-43). All investigators proposing clinical research should read the "NIH Guidelines for Inclusion of Women and Minorities as Subjects in Clinical Research (https://grants.nih.gov/grants/guide/notice-files/NOT-OD-02-001.html); a complete copy of the updated Guidelines is available at https://grants.nih.gov/grants/funding/women_min/guidelines_amended_10_2001.htm. The amended policy incorporates: the use of an NIH definition of clinical research; updated racial and ethnic categories in compliance with the new OMB standards; clarification of language governing NIH-defined Phase III clinical trials consistent with the new PHS Form 398; and updated roles and responsibilities of NIH staff and the extramural community. The policy continues to require for all NIH-defined Phase III clinical trials that: a) all applications or proposals and/or protocols must provide a description of plans to conduct analyses, as appropriate, to address differences by sex/gender and/or racial/ethnic groups, including subgroups if applicable; and b) investigators must report annual accrual and progress in conducting analyses, as appropriate, by sex/gender and/or racial/ethnic group differences.
Inclusion of Children as Participants in Clinical Research:
The NIH maintains a policy that children (i.e., individuals under the age of 21) must be included in all clinical research, conducted or supported by the NIH, unless there are scientific and ethical reasons not to include them.
All investigators proposing research involving human subjects should read the "NIH Policy and Guidelines" on the inclusion of children as participants in research involving human subjects (https://grants.nih.gov/grants/funding/children/children.htm).
Required Education on the Protection of Human Subject Participants:
NIH policy requires education on the protection of human subject participants for all investigators submitting NIH applications for research involving human subjects and individuals designated as key personnel. The policy is available at https://grants.nih.gov/grants/guide/notice-files/NOT-OD-00-039.html.
NIH Public Access Policy:
NIH-funded investigators are requested to submit to the NIH manuscript submission (NIHMS) system (http://www.nihms.nih.gov) at PubMed Central (PMC) an electronic version of the author's final manuscript upon acceptance for publication, resulting from research supported in whole or in part with direct costs from NIH. The author's final manuscript is defined as the final version accepted for journal publication, and includes all modifications from the publishing peer review process.
NIH is requesting that authors submit manuscripts resulting from 1) currently funded NIH research projects or 2) previously supported NIH research projects if they are accepted for publication on or after May 2, 2005. The NIH Public Access Policy applies to all research grant and career development award mechanisms, cooperative agreements, contracts, Institutional and Individual Ruth L. Kirschstein National Research Service Awards, as well as NIH intramural research studies. The Policy applies to peer-reviewed, original research publications that have been supported in whole or in part with direct costs from NIH, but it does not apply to book chapters, editorials, reviews, or conference proceedings. Publications resulting from non-NIH-supported research projects should not be submitted.
For more information about the Policy or the submission process please visit the NIH Public Access Policy Web site at http://publicaccess.nih.gov/ and view the Policy or other Resources and Tools including the Authors' Manual (http://publicaccess.nih.gov/publicaccess_Manual.htm).
Standards for Privacy of Individually Identifiable Health Information:
The Department of Health and Human Services (DHHS) issued final modification to the "Standards for Privacy of Individually Identifiable Health Information", the "Privacy Rule", on August 14, 2002 . The Privacy Rule is a federal regulation under the Health Insurance Portability and Accountability Act (HIPAA) of 1996 that governs the protection of individually identifiable health information, and is administered and enforced by the DHHS Office for Civil Rights (OCR).
Decisions about applicability and implementation of the Privacy Rule reside with the researcher and his/her institution. The OCR website (http://www.hhs.gov/ocr/) provides information on the Privacy Rule, including a complete Regulation Text and a set of decision tools on "Am I a covered entity?" Information on the impact of the HIPAA Privacy Rule on NIH processes involving the review, funding, and progress monitoring of grants, cooperative agreements, and research contracts can be found at https://grants.nih.gov/grants/guide/notice-files/NOT-OD-03-025.html.
URLs in NIH Grant Applications or Appendices:
All applications and proposals for NIH funding must be self-contained within specified page limitations. Unless otherwise specified in an NIH solicitation, Internet addresses (URLs) should not be used to provide information necessary to the review because reviewers are under no obligation to view the Internet sites. Furthermore, we caution reviewers that their anonymity may be compromised when they directly access an Internet site.
Healthy People 2010:
The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2010," a PHS-led national activity for setting priority areas. This PA is related to one or more of the priority areas. Potential applicants may obtain a copy of "Healthy People 2010" at http://www.health.gov/healthypeople.
Authority and Regulations:
This program is described in the Catalog of Federal Domestic Assistance at http://www.cfda.gov/ and is not subject to the intergovernmental review requirements of Executive Order 12372 or Health Systems Agency review. Awards are made under the authorization of Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR 52 and 45 CFR Parts 74 and 92. All awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Policy Statement. The NIH Grants Policy Statement can be found at https://grants.nih.gov/grants/policy/policy.htm.
The PHS strongly encourages all grant recipients to provide a smoke-free workplace and discourage the use of all tobacco products. In addition, Public Law 103-227, the Pro-Children Act of 1994, prohibits smoking in certain facilities (or in some cases, any portion of a facility) in which regular or routine education, library, day care, health care, or early childhood development services are provided to children. This is consistent with the PHS mission to protect and advance the physical and mental health of the American people.
Loan Repayment Programs:
NIH encourages applications for educational loan repayment from qualified health professionals who have made a commitment to pursue a research career involving clinical, pediatric, contraception, infertility, and health disparities related areas. The LRP is an important component of NIH's efforts to recruit and retain the next generation of researchers by providing the means for developing a research career unfettered by the burden of student loan debt. Note that an NIH grant is not required for eligibility and concurrent career award and LRP applications are encouraged. The periods of career award and LRP award may overlap providing the LRP recipient with the required commitment of time and effort, as LRP awardees must commit at least 50% of their time (at least 20 hours per week based on a 40 hour week) for two years to the research. For further information, please see: http://www.lrp.nih.gov.
Weekly TOC for this Announcement
NIH Funding Opportunities and Notices
Office of Extramural
Research (OER)
National Institutes of Health (NIH)
9000 Rockville Pike
Bethesda, Maryland 20892
Department of Health
and Human Services (HHS)
Note: For help accessing PDF, RTF, MS Word, Excel, PowerPoint, Audio or Video files, see Help Downloading Files.


text:
Click any letter (A-Z) to jump to the corresponding section of the alphabetically-ordered glossary list.
To search the glossary, enter a term to search for, then click the Search icon.
Educate yourself on a variety of financial topics.
A host of financial tools to assist you.
Timely Newsletters to help you stay current.
A dynamic library of videos.
These magazine-style flipbooks provide helpful information.
Financial terms from A to Z.
Manage your taxes and prepare for the upcoming tax season.
July 16, 2019 @ 11:44 AM
Market data delayed per exchange rules.
All quotes are in US Eastern Time (EST).
Market data provided by ICE Data Services. ICE Limitations. Powered and implemented by FactSet. Legal Statement.
Kimberly A. Hankins is a Registered Representative of and offers securities products & services through Royal Alliance Associates, Inc. Member FINRA/SIPC, a registered broker-dealer. In this regard, this communication is strictly intended for individuals residing in the states of:
No offers may be made or accepted from any resident outside the specific state(s) referenced.
Advisory services offered through Royal Alliance Associates, Inc., a Registered Investment Advisor.
Mission Coast Financial is not affiliated with Royal Alliance Associates, Inc., or registered as a broker dealer or investment adivsor.
Fixed Insurance is offered by Kimberly A. Hankins as a licensed agent independent of Royal Alliance Associates, Inc.
California Insurance License 0E56411
A broker-dealer, investment adviser, BD agent, or IA rep may only transact business in a state if first registered, or is excluded or exempt from state broker-dealer, investment adviser, BD agent or IA rep registration requirements, as appropriate. Follow-up, individualized responses to persons in a state by such a firm or individual that involve either effecting or attempting to effect transactions in securities, or the rendering of personalized investment advice for compensation, will not be made without first complying with appropriate registration requirement, or an applicable exemption or exclusion.
For information concerning the licensing status or disciplinary history of broker-dealer, investment adviser, BD agent, or IA rep, a consumer should contact his or her state securities law administrator.

subset: commoncrawl


text:
Camlock female coupler stainless steel
Quick connect camlock couplings fittings are the economical, convenient and simple way to transfer liquids and dry products. available in a wide of range of materials and sizes to suit most applications ( Such as: In Petrochemical Industries, Fertilizers, Atomic Energy, Power Plants, Industrial & Hydraulic products serving the oil & gas industries, chemical industries, steel plants, mining industries, oil refinery industries ect.)
|A-A59326( superseding MIL-C-27487 ) or DIN2828
|1/2", 3/4", 1", 1-1/4", 1-1/2", 2", 2-1/2",3", 4", 5", 6"
|Body material
|Stainless steel
|NPT, BSP (We usually make the female thread parallel BSPP, male thread tapered BSPT )
|NBR, other materials are available on request
|Casting methos
|Investment casting
|Handles material
|Stainless steel
|Pin and Ring , safety clip material
|Stainless steel
Other available material of Camlock Coupling: Brass, Aluminum, PP, Nylon
|Male Adaptor with Female BSP or NPT thread
|Female Coupler with Male BSP or NPT thread
|Female Coupler with Hose tail
|Female Coupler with Female BSP or NPT thread
|Male Adaptor with Hose tail
|Male Adaptor with Male BSP or NPT thread
|Dust Cap female coupler for Adaptors
|Dust Plug male adaptor for Couplers
How cam & groove couplings work
The Coupling is connected by simply opening the coupler arms and inserting the adaptor into the coupler. The cam arms are then closed under normal hand pressure to complete joint
USES for Camlock Fittings
Agriculture- Our polypropylene couplings are resistant to most acids. These work as ideal hose connections on agricultural sprayers. This will save much time during refilling of the tanks.
Paint, Inks and Dyes- Those who manufacture paints inks and dyes must require the frequent change of hoses to find the correct mix. Our fittings are able to endure the gathering of coatings without damage to the camlock coating.
Oil Distribution- Camlocks are the standard connection uses for hoses involving the delivery of fuel to service stations. There are no tools needed to make the connection, and the risk of cross threading is completely avoided.
Cleaning- Many industrial cleaning products require hoses. For example, hoses can easily disconnected for storage to facilitate transport or for removal in the event of a blockage occurring.
Pump Connections- Camlocks are commonly used at the inlet and outlet connections of pumps
Drum Filling- A coupling can be incorporated into a system allowing for rapid filling of chemical drums. Our camlocks are suitable for suction, delivery and vacuum service.
Military- Our camlock couplings are widely used by NATO forces throughout the world to facilitate fast strategic placement. With the US Military spec of MIL-C-27487 (A-A-59326), the aluminum anodized couplings can be used for such requirements.
Packaging: Inner plastic bag, then standard export caton, plywood pallet.
Shipping by: express, air , sea
Fuzhou Hongxing Machinery Co.,Ltd. is a major manufacturer and exporter of camlock couplings, fittings and accessories in Fuzhou, Fujian, China. We have more than 20 years of experience in manufacturing hose couplings and fittings.
Our main products are pipe fittings, camlock coupling, KC nipple, Hose Mender, Universal Air Hose Coupling, wash down gun, Whipcheck Safety Cable, hose clamp, ground joint coupling, ect.
Photos of our factory
FAQ1.May I require samples before deciding to purchase from you?
Yes, we can supply samples free of charge if not too many, but we usually require the client to pay the freight.
2.Can I add logo to the products?
Yes, but we usually have quantity requirement if the client want to add logo to the products.
You can contact us for the details.
3.Can you design or produce new products for as per requested?
Yes, we are good at to develop new products according to the clients requirements, when you have samples
or drawing needing a factory to develop for you, please let me know, we will try our best to help you.
4.What is your Min order?
We don't have min order requirement, small order is acceptable, but we hope the order to be more than
USD5000 which the export charge will not occupy a big proportion. The clients should be pay for the export
charge if the order amount less USD5000.
5.What is the payment terms you can accept?
T/T, irrevocable L/C at sight, western union
6.What is the delivery time for an order?
The delivery time within 30-45 days after you confirm the order, according to your quantity.
7.How can I know the material is correct and acceptable?
Material certificate is available on request.
8.What if I want to get a product catalog?
Please email us for the catalog.
9.I can't find the products I want on your site, are you able to help me to locate it?
We are not able to put every product we can do on this site, however, we have many years of experience of
couplings and related products and are always pleased to try to help you.Contact us if you need more details on Camlock Female Coupler. We are ready to answer your questions on packaging, logistics, certification or any other aspects about Camlock Manufacture、Quick Coupler Female. If these products fail to match your need, please contact us and we would like to provide relevant information.
Product Categories : Camlock Coupling


text:
*** THIS CONTEST HAS NOW ENDED! NO FURTHER COMMENTS WILL COUNT TOWARDS THE GIFT CARDS** So it's been a while since I've posted. I know. But if I am going to break the silence it's going to be about something important. So let's talk about it. GLUTEN FREE. As some of you remember, I went [Read More]
Gluten Free Challenges and how Pizza hut can help
Leopard print belt sale!
Happy Labor Day weekend!!! I have a killer deal on these darling leopard print belts! They are the perfect addition to your fall wardrobe! It goes with EVERYTHING and is just the fun splash of print and color that you are looking for! ONLY $7 with FREE SHIPPING!! SALE HAS ENDED! **all the [Read More]
St Patricks Day Dinner Ideas
Themed dinners can be so fun! Especially if they are for a holiday….I am not a big fan of green so my closet is not the place to turn to, to celebrate St Patricks day. So I am turning to my kitchen and creating a fun dinner instead! Delicious enough for adults to enjoy but [Read More]
Kate and Linny – new deal a day site
If you haven't already heard of "Kate and Linny" , you're missing out. First things first, sign up HERE!! Katherine (Kate) and Lindsay (Linny), the two fabulous mamas behind Kate and Linny, work together to bring unique and different products to their loyal customers. Kate and Linny offers limited-time sales on products perfect for your home [Read More]
How Jimmy Dean saves me every week!
This post is part of a social shopper marketing insight campaign with Pollinate Media Group™ and Jimmy Dean, but as always all my opinions are my own and I only brag about products I truly love and use. #pmedia #RedboxBreakfast http://cmp.ly/3/8vNxcO. As most of you probably know, I travel a ton for my Job. I [Read More]
Target cartwheel app – and a $1000 gift card giveaway
As you know I have often expressed my love affair for Target! This store just speaks to me! Amazing home decor, clothing, I can do my grocery shopping at the same time! *swoon* BUT….What would make Target even better than it already is?? COUPONS!! Well look no further! Target has an app called CARTWHEEL that offers [Read More]
DIY wedding gift ideas with #targetwedding and a giveaway
My darling sweet cousin Brooke just got married last Saturday! Wedding are such a magical time aren't they? She was such a beautiful bride and I was thrilled when they registered at Target!! Cause as we all know – target is one of my FAVORITE places!! The problem is they couldn't register for much since [Read More]
DIY Sharpie Deer head silhouette canvas
This post is part of a social shopper marketing insight campaign with Pollinate Media Group™ and Sharpie, but all my opinions are my own. I only indorse products I use and shops I really do love. #pmedia #StaplesSharpie http://cmp.ly/3/8vNxcO. I am not the best at buying new holiday decor! I always tell myself "what's the [Read More]
#MyKindOfHoliday a target gift guide and giveaway
This post is brought to you by Target, but all opinions and content are my own – cause I really am obsessed with Target. Follow along with #MyKindOfHoliday or #MKOH Can you believe it is less than TWO WEEKS until Christmas! I have been so behind this year on making sure all my holiday shopping [Read More]


text:
Don't see your question? Visit our help section.
Get access to great in-store deals and local pick-up
Sign up for our email deals newsletter!
Take on an unlimited array of platform-racing challenges in the unreal world of Trials Fusion.
Best-In-Class Platform-Racing
Rock-solid motocross physics and reality-bending course designs come together for an over-the-top racing experience that no other game can provide. Show your fearless side with the brand new FMX tricks system, and choose your path towards victory on branching courses. The finish line is the ultimate goal, but the challenge is everything before it.
Ubiqitous Competition
Whether you're racing alone, with friends, or in a worldwide tournament, competition is all around you. Its variety and depth will offer limitless ways to scratch your competitive itch, and the opportunities keep coming. With ongoing support for special tournaments and events, team racing, and much more coming ahead, your competition days will never be done.
Vibrant User-Generated Content Community
Immerse yourself in a boundless Trials experience with custom track designs made possible by the in-game Editor Mode. With a user-generated content community that boasts some of the most creative and skilled track creators in the world, Trials Fusion offers new track after new track and opens the door to a world of possibilities only the crazy minds of Trials fans can bring together.
© 2014 Ubisoft Entertainment. All rights Reserved. Trials Fusion, Ubisoft and the Ubisoft logo are trademarks of Ubisoft Entertainment in the US and/or other countries.
Pro Price


text:
With the tying runs on base and two outs in the ninth inning, Jose Bautista struck out and then proceeded to scream at the umpire "because you f***ing suck, that's why!"
Bautista then went toe-to-toe with the umpire, got ejected, and eventually threw his helmet and bat on to the field as he exited.
Bautista was upset about the first pitch of the at bat, which was a called strike. Even though it appeared to be a good call, Bautista started arguing. He then swung at two straight bad pitches, including one in the dirt on the third strike.
That's when Bautista lost it.
The video below of the Blue Jays broadcast shows the entire sequence. But the true gem comes from the Rangers broadcast...
Tom Grieve: That's a strike too, now argue with the umpire.
Steve Busby: And he's [ejected]. Make it look like it was the umpire's fault you swung at a pitch in the dirt.
Tom Grieve: You turn into a crybaby when you act like that. Go sit down and look at the pitch and then apologize to the umpire. That was a display of immaturity right there...it wasn't the umpire that made you swing at two pitches way out of the strikezone...Don't blame it on the umpire. Go back to the dugout and look in the mirror.
The only thing that might save Bautista from a suspension on this play is that the exchange was rather brief. But he is almost certainly going to be fined for the outburst.
Here's the final strike...
Your browser does not support iframes.


text:
An extraordinary collection of tricks using coins and currency. Imagine entertaining an audience with ordinary money. These superb videos are someof the best values in magic.
Volume 1 - Coins Across, Hanging Coins, 41 Cent Miracle, Credit Card Quickie, Bent Penny Transposition
Volume 2 - Copper Silver Transposition, Coins Thru Table, Two Dollar Bill Tear, Coins Thru Table Kicker
Volume 3 - Coin From Pen Cap, Flying Eagles, Coins Thru Silk, E-Z Money
Do you own this product? Write a review.


text:
It's been proven that children who
aren't hungry feel better, learn better and behave better. The EVSC's
Office of Food and Nutrition is responsible for providing breakfast and
lunch everyday at the corporation's 39 schools. The Office strives to
serve healthy, nutritious meal options and follows dietary guidelines
set forth by the United States Department of Agriculture (USDA).


text:
Wales winger Gareth Bale has vowed to honour Gary Speed by aiming to continue the progress made under the national team manager.
Former Leeds, Everton, Newcastle, Bolton and Sheffield United midfielder Speed died at his home on the outskirts of Chester on Sunday, with sources confirming he was found hanged.
Speed had recently lead Wales to four wins in five games, raising hopes they could qualify for the 2014 World Cup, and Bale told tottenhamhotspur.com: "We were on the up, he changed the way we play and the whole mentality of our game. It is a massive loss, but we will try and carry on the best we can in his honour."
Copyright (c) PA Sport 2011, All Rights Reserved.


text:
Terrell Sinkfield's interesting NFL journey continues.
The Giants reached a deal with Sinkfield — a name perhaps familiar to draftniks and those who follow the transactions — on Wednesday.
This marks the fourth NFL club Sinkfield has signed with in about a 3.5-month span since going undrafted out of Northern Iowa. He previously had stints with the Dolphins, Packers and Bills. Buffalo waived him on Monday.
Now, Sinkfield is getting a chance with the Giants, who have some injury issues at wide receiver, as Michael Eisen of Giants.com noted.
The 6-foot, 200-pound Sinkfield made some headlines before the draft with some swift 40-yard dash clockings. While he hasn't yet found a lasting NFL home, he's at least done enough to pique the interest of NFL teams. Even if he doesn't make the roster, landing with the Giants could serve him well, for it appears there are some snaps for the taking. Ideally for Sinkfield, he can stay on the roster for the final two preseason games and get some on-field work for the Giants — and other teams — to evaluate.


text:
MCM summer sunglassesCategories:Jewelry & Watches
Summer occasion, MCM brand image of classic blend of classic elements with modern design aesthetics, presenting the new eyewear collection again. With excellent technology and advanced technology to create high-quality eyewear collection, more innovative design and unique style of the unexpected highlights the brand's unique creative spirit.
Navy blue retro round glasses shooting Bazaar jewelry fashion large
Adhering to the retro style and modern appearance of the perfect fusion of bold section metal frame glasses lens covered with MCM classic pattern. Double metal frame to make the appearance more perfect. Design with light bright gold, blue and bright gold and copper.
Wine red cat eye sunglasses
Coloring balance each cat eye frame with the classic distinctive achievements of the bold avant-garde style. Metal trim lens combination decorated with metal rivet detail of the frame, and metal brand plaque decorated with temples to each other. Series with black, tortoiseshell and red wine.
Supermodel Erin Heat at MCM boutiques try surreal translucent frame sunglasses
Lightweight and translucent colored implementing brand fashion concept and design aesthetics, the avant-garde of the frame shape with smooth lines and metal rivets highlight industrial design elements of fun. Series with gold satin with gray satin and gold with light gold.
Diamond Rivet large frame sunglasses
Series with elegant diamond shape for the design blueprint, the unique triangular design clear and neatly decorated in the mirror leg beams and decorated with metal logo. Frame in front of the semi-metal rivet diamond-shaped frame for the King of crude to create a unique fashion style. Series with black, tortoiseshell, wine red, light brown and green.
Classic frame design, with geometric mirror leg rivets and small metal diamond as a decoration, to create a brand well-known masterpiece. Inspired by the iconic MCM backpack series, brand logo placed in the avant-garde designs temples. Series with black, tortoiseshell, wine red, blue and pink nude.
Inspired by MCM classic leather series, the quality of its printed sheet mirror leg special brand classic pattern. Wide rectangular frame with golden brass nameplate next to the temple, consistent with the nameplate on the MCM handbag. Series with matte black, light rose gold and matte brown with a golden yellow, respectively.
Both bold and avant-garde and classic, retro brow with round mirror frame, and stylish metal trim, front frame decorated with diamond shaped rivets two and a half, and the mirror leg of MCM metal nameplate embraced each other. Series with bright gold with a black, light gold with tortoiseshell, horn with a bright golden brown, light gray-blue and golden horns with bright gold with horns khaki.
A sleek sophisticated flight details of classic metal glasses more Ambilight. Easy to fold its lightweight frame structure, unique. MCM logo subtly placed in the upper right corner of the lens, glasses with matt black, glossy pink gold, bright gold and black chrome-plated.
Tags: sunglasses MCM
comnum(0) tbcount(0) tbcount(289)
Rihanna Designs (and Models) Futuristic Sunglasses for DiorCategories:Jewelry & Watches Rihanna wears sunglasses from upcoming Dior collaboration
A year and a half after being named a brand ambassador for Dior, singer Rihanna has collaborated with the French fashion house once again for a new range of sunglasses. Called 'Rihanna', the shades will be sold solely at Dior stores in June, according to WWD. For the official promotional images, who better but Rihanna herself to model the futuristic, visor inspired designs? Jean-Baptiste Mondino photographs the pop star modeling the collection while wearing a form-fitting bodysuit. In all, there are six colors with the option of a gold-plated version.
RIHANNA – DIOR SUNGLASSES COLLABORATIONRihanna rocks one-piece and sunglasses from her Dior collaborationRihanna wears purple frames from Dior collaborationRihanna and Dior's sunglasses collection hits stores in June 2016Rihanna x Dior sunglassesRihanna x Dior sunglasses
Images via WWD
FLASHBACK: RIHANNA – DIOR 'SECRET GARDEN' IV CAMPAIGNRihanna poses in Dior 'Secret Garden' film
Last year, the world got its first glimpse at Rihanna's Dior ambassadorship with the release of 'Secret Garden IV'. The Barbadian beauty posed in Versailles for the campaign and film featuring her in dramatic looks captured by Steven Klein.Rihanna is sultry for Dior's 2015 Secret Garden campaign.Rihanna is sultry for Dior's 2015 Secret Garden campaign.
Tags: Dior sunglasses
comnum(0) tbcount(0) tbcount(274)
NEW CLASSICS: 8 MODERN AVIATOR SUNGLASSESCategories:Jewelry & Watches Free People Funk Soul Aviator Sunglasses
Step out this summer in style with a pair of aviator sunglasses. The classic shape is a no brainer when it comes to picking that perfect frame silhouette, but what if you want something a little more updated? No worries, we rounded up eight aviator styles with modern touches. From mirrored lenses to rose gold coloring and metal accents, check out more cool aviator sunglasses below.
Tags: sunglasses
comnum(0) tbcount(0) tbcount(253)
Get Excited for Summer with These Designer SunglassesCategories:Jewelry & Watches
Tom Ford Rounded Metal Sunglasses, Cedric Charlier Strapless Peplum Dress
A perfect way to bring some personality to your outfit is with a standout pair of sunglasses. Saks Fifth Avenue provides some inspiration with a new trend guide called 'Sunset BLVD.', which focuses on the spring-summer 2016 season's most statement making designer shades. From Dolce & Gabbana's printed cat eye sunglassesto Gucci's glittered shades, these glasses are sure to be a conversation starter.
Gucci Oversized Glitter Sunglasses
Roberto Cavalli Crystal Embellished Metal Aviator Sunglasses, Roberto Cavalli Beaded Dress
Dolce & Gabbana Printed Cat Eye Sunglasses, Dolce & Gabbana Fitted Crepe Dress
Dior Aviator Sunglasses, Mary Katrantzou Printed Dress
Ray-Ban Gatsby Mirrored Round Sunglasses
Tags: sunglasses
comnum(0) tbcount(0) tbcount(281)
Chanel Shield Runway Sunglasses Reference GuideCategories:Jewelry & Watches
Introducing the Chanel Shield Runway Sunglasses. Chanel's latest sunglasses was one of the hottest accessories in the Spring/Summer 2016 runway show, where it was first presented. The Shield Runway Sunglasses comes in a silver metal frame, while the mirror lenses are available in three colors, Grey, Blue and Red. It has 100% UVA and UVB Protection CE. The sunglasses are an updated version of classic aviators, as it features a visor style with a futuristic design.
Style & Price
|Chanel Shield Runway Sunglasses
Style Inspiration
Tags: Chanel sunglasses
comnum(0) tbcount(0) tbcount(398)
Rihanna and Dior Launch Futuristic SunglassesCategories:Jewelry & Watches
Hats off to Dior once again! The premium brand keeps up delighting the audience to bits albeit without yet any appropriate candidate to step into the shoes of the brand's last creative director Raf Simons. Instead Dior's creative team is drawing a bead on bringing to the table celebrity-oriented campaigns and collaborations. Rihanna has yet again united her Barbadian Bad Gal essence with the luxury brand to launch a collection of new futuristic all-around gorgeous sunglasses dubbed simply "Rihanna".
As WWD reports, Dior's Rihanna sunglasses collection will come into season exclusively at Dior stores starting from early June and will feature only one frame design in six color variations. The silver, pink, blue, green and red versions will come with a price tag of $840, while the 24-karat gold-plated one will retail a little bit higher – for $1,950.
This kind of flat edgy frame hit upon RiRi not at this point. She has always been obsessed with that futuristic eyewear on La Forge from "Star Trek" and as she herself remarked, when she was shown all the materials she could play with, they all surprisingly came together to form that long-cherished design.
"We are very pleased to partner for the second time with Rihanna," said Dior chief executive officer Sidney Toledano. "She is an artist, an entertainer, an entrepreneur, a philanthropist, and a style icon for today's generation."
Let us recall that it was last year when the Dior + Rihanna tandem kick-started with Rihanna continuing the much-buzzed-about "Secret Garden IV" – Versailles series starring in the short film shot by Steven Klein, where she was meandering through the lofty halls of the Palace of Versailles all in darkness and shining up hill and down dale with Dior sunglasses, handbags and the clothes from the Esprit Dior collection shown in Tokyo in December 2014.
And now one year later when she has already earned herself a stable place in the fashion arena via her first ever full Fenty x Puma fall 2016 collection, the collaboration with American sock and underwear brand Stance and recently also Manolo Blahnik over a new shoe line, premium house Dior chooses the very Rihanna for their first ever design project with the brand's ambassador.
Moreover, according to the brand's eyewear designer Mathieu Jamin, this is their fist experience to come together with a celebrity over a new design project, which was decidedly crowned with immense success.
"She chose all the materials," Jamin said. "We had a lot of different samples with different effect of metals. She chose all the lenses and took time to match all the colors together to see if it was right on her face. It was really important to her."
Rihanna herself described the design process being something so easily handled. It was within a single day that the brand's sunglass archives were checked, the flat futuristic design determined and shades and materials cherry-picked. Then it was a matter of weeks before the dark beauty could see the first prototype of her star-trek-inspired sunglasses.
Though the launch of Dior's Rihanna sunglasses will not be accompanied by any official campaign, Jean-Baptiste Mondino captured RiRi showing off each version of the audacious sunglasses for Dior's in-house editorial. But that's on behalf of Dior for our bait moments; RiRi's bait was even stronger when she shared her eyewear-centered photo on her Instagram account thus precisely teaching us how it is best to rock any of these cool pair of sunglasses through real life avenues.
Tags: Dior sunglasses And Rihanna


text:
Police Brutality: Cop Punches Teen 14 Times & Tasered While He's Handcuffed In South Carolina!
S. Carolina teen beaten by police officer
Please click the "Report" button below if the video on this page is not working properly.
Comments will only be displayed by verified emails. No Spamming or Racism.


text:
May 28, 2008
LOS ANGELES - This summer, UCLA Anderson will join a select group of business schools in a new program designed to assist veterans with disabilities. The Entrepreneurship Bootcamp for Veterans with Disabilities (EBV) will offer training in small business start-up and management to servicemen and women injured in the line of duty since 2001. The EBV consortium of schools represents a partnership of Syracuse University, UCLA, Texas A&M University, and Florida State University - each which will offer the EBV program on their campuses this year. This consortium represents one of the first, significant partnerships of its type since World War II, with business schools at American universities opening their doors to veterans who are motivated by business ownership.
It is estimated that the number of service people wounded in the war on terror is now nearly 40,000. In addition, the number of soldiers suffering from post-traumatic stress and other psychological challenges is significant. For many of them, traditional employment represents a lifelong challenge. Throughout American history, entrepreneurship has been a means for veterans to make a way for themselves and their families, and to re-engage the economic engine of their communities and ultimately the nation. Business ownership offers veterans the opportunity to "own their futures" while also offering the flexibility to accommodate the unique challenges associated with a service-connected disability.
In response to the need of these self-sacrificing Americans, Syracuse University created the EBV program and enrolled their first class of 20 participants in the summer of 2007. The program integrates world-class faculty, entrepreneurs, disability experts and business professionals in an educational program that trains veterans in the entrepreneurial competencies associated with small business ownership. Last fall, UCLA Anderson's Harold and Pauline Price Center for Entrepreneurial Studies was invited to offer the EBV in its second year. "We are honored to participate in the EBV consortium, said Alfred E. Osborne, Jr., senior associate dean of UCLA Anderson and faculty director of the Price Center. "As a public institution, UCLA has a legacy of service, and we look forward to helping these distinguished young men and women develop the skills they will need for the next phase of their careers."
The four institutions have committed to a three phase, standardized EBV program format, ensuring that all participants receive a consistent, high-quality experience. Phase I is a self-study session in which the veterans complete courses through online discussions moderated by university faculty. Phase II is a nine-day residency at participants' EBV university, where they will learn to develop business concepts and understand the basic elements of small business management. Phase III involves 12 months of ongoing support and mentorship provided to the veterans by the faculty experts at the EBV universities. Throughout the EBV experience, students engage in workshops to develop strategies for raising capital, attracting customers, and ultimately writing business plans that are most effective for their business model.
For the participating veterans, the program will be entirely free, including travel and accommodations. The Price Center is continuing to accept donations to underwrite the cost of the program.
About the Harold and Pauline Price Center for Entrepreneurial Studies
The Harold and Pauline Price Center for Entrepreneurial Studies, a recognized leader in entrepreneurial education. Now celebrating its 20th year, the Price Center supports teaching, research, extracurricular activities and management development programs in the areas of entrepreneurship, venture capital and social enterprise at UCLA Anderson. 90% of UCLA Anderson's full time MBA students enroll in entrepreneurial electives while at Anderson, and more than half are active members of the student-run Entrepreneur Association. The Center is known for its extensive outreach and the impact of its management development programs, which provide entrepreneurial education to such diverse groups as directors of Head Start agencies and community health organizations; leaders of NGOs in Africa that are working on the HIV/AIDS crisis; founders and executives of entrepreneurial companies (including minority-, women- and disabled veteran-owned enterprises); directors and officers of venture-backed and public companies; and K-12 teachers working to develop entrepreneurial curricula, among others.
About UCLA Anderson School of Management
UCLA Anderson School of Management, established in 1935, is regarded among the very best business schools in the world. UCLA Anderson faculty are ranked #1 in "Intellectual Capital" by BusinessWeek and are renowned for their teaching excellence and research in advancing management thinking. Furthermore, the finance faculty is ranked #1 in research publications in the four leading peer-reviewed journals by the Financial Management Association. Each year, UCLA Anderson provides management education to more than 1,600 students enrolled in MBA, Executive MBA, Fully-Employed MBA and doctoral programs, and to more than 2,000 professional managers through executive education programs. Combining highly selective admissions, varied and innovative learning programs, and a world-wide network of 35,000 alumni, UCLA Anderson develops and prepares global leaders.


text:
Fred Sanford Gorelick, MD
Henry J. and Joan W. Binder Professor of Medicine (Digestive Diseases) and of Cell Biology; Director Investivative Gastroenterology NIH T32, Internal Medicine; Deputy Director, Yale M.D., Ph.D. Program
Departments & Organizations
Cell Biology: Membrane Traffic
Internal Medicine: Digestive Diseases: Pancreatic Diseases Program | Investigative Medicine Program | Liver Center
Yale Combined Program in the Biological and Biomedical Sciences (BBS): Molecular Cell Biology, Genetics and Development
Office of Cooperative Research
After completing medical school and internal medicine training at the University of Missouri, Dr. Gorelick trained at Yale in Gastroenterology. After his clinical training, he began basic science training with Dr. James Jamieson at Yale. During that period he described calcium-calmodulin dependent protein kinase II and subsequently worked with Dr. Paul Greengard (Rockefeller University) to examine the enzyme's mechanism of activation, a response critical to neuronal memory.
His later work has focused on the mechanisms of acute pancreatits and how digestive enzymes, such as trypsin, are activated within the pancreas during this disease. Dr. Gorelick sees patients with gastrointestinal diseases at the VAMC in West Haven, CT. He is also the Deputy Director for the Yale physician Scientist program and directs a year-long course for the group that links basic science to clinical disease. He has also been the Director of the Yale Program in Investigative Gastroenterology for over 10 years. His laboratory at the VA studies the molecular mechanisms related to acute pancreatitis with a goal of developing tools that prevent or lessen disease.
Education & Training
|University of Missouri (1973)
|Visiting Scientist
|Rockefeller University
|Post Doctoral
|Yale University
|GI Fellow
|Yale University School of Medicine
|University of Missouri
Honors & Recognition
Lifetime Mentorship AwardAmerican Gastroenterological Association (2019)
Howard Spiro Teaching AwardYale Section of Digestive Diseases (2012)
American Association of PhysiciansAAMC (2010)
William Go Life-time Achievement AwardAmerican Pancreatic Association (2008)
Bohmfalk Teaching Award in Basic ScienceYale University (2007)
ASCIAmer Soc Clin Investigation (1990)
Morton Grossman Research AwardAmerican Gastroenterological Association (1984)
Professional Service
DOD PRMRP-P2rmis pancreas (2012 - 2014) Chaired grant review committee and reviewed grant submissions
NIH (2009) NIH ZDKi GRB-2 Study Section
Yale University (2009 - 2013) Deputy Director Yale MD, PhD Program
Yale University School of Medicine (2005 - 2017) Director NIH T32 Training Program in Investigative Gastroenterology
National Institutes of Health (2004 - 2006) NIH Study Section Chair (CIGP)
NIH NIDDK (2001 - 2004) Full-time member NIH GMA2 grant review committee
American Pancreatic Association (1998 - 1999) President
American Gastroenterological Association Pancreatic Section (1996 - 2000) Co-chair then chair; organized pancreatic research and state of the art talks on pancreatic diseases for 4 day international meeting.


text:
Hi there! Welcome to Paladins forums!
Nice to see you here. If you want to check the community threads just visit the proper section. Please read the Code of Conduct and the FAQ before of posting.
You can fin useful info in the Headline or you can use the search feature for find common issues.
Have a nice day!
Beta Player


text:
Sears Scores 15 Points To Pace Bulldogs
EVANSVILLE, Ind. – Evansville made the plays down the stretch to knock off Yale Friday in the NABC Coaches vs. Cancer Classic. The Purple Aces also had a little bit of good fortune.
Ned Cox banked home a three-pointer with the shot clock winding down as part of a late 7-0 run as Evansville held off the Bulldogs 66-56 before a nervous crowd of 4,112 at the Ford Center.
Justin Sears' layup pulled Yale within three, 59-56, with 3:34 remaining. The Bulldogs turned up the defensive pressure and appeared to have Evansville in trouble before Cox made the back-breaking, long three-pointer.
The Purple Aces (1-2) then scored the final four points to seal the victory.
The loss spoiled a fine performance from Sears, a freshman who paced the Bulldogs with 15 points. He was 7-of-9 from the field and added seven rebounds. Austin Morgan scored 13 points and Brandon Sherrod had seven for Yale (0-3).
DJ Balentine led four Evansville players in double figures with 16 points. Jordan Jahr added 12 points and Ryan Sawvell and Lewis Jones each scored 10.
The game featured six ties and 15 lead changes.
"We played with a lot of energy and effort," Evansville head coach Marty Simmons said. "Yale is a very good, well-coached team."
The Purple Aces led by eight, 46-38 six minutes into the second half, but the Bulldogs stormed back with a 10-0 run, capped by a Sam Martin three-pointer that put Yale ahead.
The teams then traded baskets for the next eight minutes until Balentine's layup gave Evansville a five-point cushion, 59-54. Sears answered with a layup but that would be Yale's last basket of the game.
The Bulldogs committed 19 turnovers, which led to 23 Evansville points.
NOTES: Sophomore Armani Cotton made the first start of his career for the Bulldogs… Yale dominated the glass, outrebounding the Purple Aces 35-22… Evansville's bench outscored the Bulldogs' bench 32-14… The Classic continues on Saturday for Yale, which plays Buffalo at 6 p.m. EST. The Bulls fell to Western Illinois 67-58 on Friday after beating Evansville 56-50 on Thursday.
Report filed by Tim Bennett, Yale Sports Publicity


text:
Administrative Statements
President Dominic Dottavio
Public accountability for student learning plays an important role at Tarleton State University, as our institution grows and strives to deliver its culture of excellence for students. Learning-outcomes assessment improves student learning by measuring results of instruction to answer essential questions: What knowledge did students learn?; What skills did students gain?; What values did students embrace? Simply stated, student-learning outcomes observed and measured lead to improved learning.
The successful atmosphere for learning thrives from teamwork between student and teacher, just as faculty partnership in assessment and accountability is crucial to improvement of the learning process. It is imperative that all faculty collaborate in the student-learning assessment process.
Results of learning-outcomes assessment benefit our students and Tarleton as a whole. All stakeholders in this process play an important role in meeting our goals for student learning, academic standards, scholarship, diversity and access, faculty and staff development and enrichment, instructional technology, curriculum development and assessment, and resource enhancement.
Academic Affairs Statement
Provost Karen Murray
Setting goals and monitoring achievement serve to benchmark academic improvement, so assessment is a driving force behind Tarleton's mission of "an academically challenging education experience" with learning grounded in real-world experience and effective teaching, research, scholarship, and service. Faculty-driven curricula, goal-setting, and student-learning assessment lead to fulfillment of our mission.
Governing Bodies
U. S. Dept. of Education
In September 2006, a Commission appointed by Margaret Spellings, the U.S. Secretary of Education, published a report on higher education entitled A Test of Leadership: Charting the Future of U.S. Higher Education. Included among the recommendations was a suggestion for institutions of higher education to increase the transparency and accountability of programs by providing comparable evidence of institutional performance.
SACSCOC - Commission on Colleges
The Commission on Colleges of the Southern Association of Colleges and Schools Commission on Colleges has embraced the concept of continuous quality improvement. The 2007 general accreditation overview states the concept of quality enhancement is at the heart of the Commission's philosophy of accreditation. Comprehensive standard 3.3.1 notes the institution identifies expected outcomes for its educational programs (including student learning outcomes for educational programs) and its administrative and educational support services, assesses whether it achieves these outcomes, and provides evidence of improvement based on analysis of those results. Standard 3.4.1 notes the institution demonstrates that each educational program for which academic credit is awarded (a) is approved by the faculty and the administration, and (b) establishes and evaluates program and learning outcomes. Also, guideline 3.5.1 requires the institution to identify college-level competencies within the general education core and provides evidence that graduates have attained those competencies.
THECB & TAMU System
In the state of Texas, the Texas Higher Education Coordinating Board and The Texas A&M University system have adopted accountability measures designed to assure monitoring and advances in the areas of quality improvement. These measures are monitored on an annual basis.


text:
Water Sports
Learn More About Water Sports Equipment
Find the gear you need to take on the water like never before
Catch the wake on a durable towable tube or shop wakeboards for sale for a fast ride down the beach. Keep safe in a life vest designed for a lightweight feel.
You'll get an up-close view of the underwater world with goggles that give you brilliant vision beneath the surface. Breathe easy with innovative snorkels and snorkeling sets that let you focus on blue waters ahead.
Quick-drying wetsuits deliver a second-skin fit that flexes with you as you ride a wave. Propel yourself forward with fins that fit comfortably and boost your leg strength. Make a splash with water trampolines or boogie boards. Glide over the water with waterskis and ensure your day on the lake is anything but ordinary.
Find towable tubes from Airhead®. Pull on a life jacket from O'Brien®. Turn to top brands Rave Sports®, Cressi®, Quicksilver® and many more.
Looking for more? Shop a great selection of Tandem Kayaks. and Inflatable Kayaks
Dive in, float on, ride surf. Discover water sports gear that keeps pace with you.


text:
In so many supernatural boy-meets-girl stories, the supernatural creature abandons their world (or vice versa) in the name of romance. But in the charming animated short High Tide, a boy from under the sea find something else on land worth pursuing.
Kristin Kemper made High Tide while at the School of Visual Arts and the soundtrack is by Clark Powell.
[via Seanan McGuire]