text:
Think Tank Helps Buffalo Superintendent Weigh Issues
Marion Cañedo wanted more time to think.
The superintendent of the Buffalo, N.Y., public schools was in the middle of a sweeping reform effort last year when the district was hit with yet another multimillion-dollar budget crisis.
To keep the 44,000-student district's strategies for improving student achievement on track, Ms. Cañedo and Donald J. Jacobs, an associate dean of the graduate school of education at the State University of New York at Buffalo, created an education think tank. The Education Innovation Consortium researches issues facing the Buffalo schools and offers proposed solutions to guide district policymakers.
"Most of the time, you have a committee here and over there reporting back ... and a thousand other things happening in a large city school district," explained Ms. Cañedo, who has been superintendent for almost three years. "There's a huge gap around the time you have for real thinking, brainstorming, and planning."
The research consortium, a nonprofit group, is guided by the district's needs. The superintendent chairs the consortium's board.
To strengthen the district's focus on data and research- driven reform efforts, Ms. Cañedo created a top administrative position—chief planning officer—to oversee progress and to serve as her liaison to the Education Innovation Consortium.
The group, which began work last year, is also actively involved in guiding the implementation of policies. Projects include a pilot program to delegate more decisionmaking authority to schools and the development of a district report card.
"The EIC is not just out there thinking lofty thoughts and passing them back," David J. Lanz, the chief planning officer, said. "It's also a group that rolls up its sleeves and gets involved directly with the work of the district."
'Work Tank'
Mr. Jacobs likens the consortium, which is financed by a $200,000 state grant and some private money, to a "work tank." In addition to the superintendent, the seven-member consortium board includes Mr. Jacobs, who heads the consortium, the dean of the university's graduate school of education, and members of the local business and philanthropic communities. With a staff of four, the consortium relies on a mix of national, state, and local experts for assistance.
That help was key for the Buffalo school system, which started an ambitious improvement effort in 2000 after receiving a detailed analysis of the district's management and operations from the Council of the Great City Schools.
The critical report by the Washington-based organization, which represents the nation's largest urban school systems, made more than 240 recommendations. The suggestions covered professional development, accountability, student achievement, school choice, and decentralized decision- making, among others. ("Urban Districts Turn to Their Peers for Hard-Hitting Tips," Feb. 28, 2001.)
While the district does have researchers and committees assigned to various problems and goals, all are terribly overburdened, Ms. Cañedo said. Now, with its own "problem-solving arm," the school system defines issues for the consortium, which in turn develops solutions to be evaluated by district staff members.
Making the consortium an independent, nonprofit organization also gives the district creative ways to problem-solve and hire consultants without "bureaucratic red tape," Ms. Cañedo added.
The consortium's direct link to the district will serve Buffalo schools well, said Shazia Rafiullah Miller, an associate director of the Consortium on Chicago School Research. Still, she said, there's also value in having an objective "outside body looking in," which is the Chicago group's role.
The Chicago consortium, founded in 1990, is an independent federation of local organizations, scholars, and foundation representatives that conducts research on Chicago's public schools. Ms. Miller said the group forms its own research agenda with some input from the city's public school educators.
Mr. Jacobs explained, however, that Buffalo's residents had lost confidence in its public schools. The city needed a more immediate and active approach to addressing the district's needs, rather than an arm's-length research organization, he said.
That's not to say that the consortium agrees with the superintendent at every turn. Mr. Jacobs said that when opinions differ between the superintendent and the consortium's other board members, they "arm-wrestle it out."
And although Ms. Cañedo expects an intellectual challenge, in the end, he said, the superintendent always wins.
Vol. 22, Issue 18, Page 5Published in Print: January 15, 2003, as Think Tank Helps Buffalo Superintendent Weigh Issues
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Larger airlines like, United Airlines, Southwest, and Frontier service the Denver International Airport. It's tops for service and amenities, plus its only 18 miles from downtown Denver. Flights generally increase from April to October, averaging $475 from Providence to Denver, and decrease in the late fall and winter to an average of $350.
Flying over the Rocky Mountains and downtown Denver is a treat, but once you land, Denver International (DEN) will continue to impress with battery charging stations, FedEx boxes in strategic locations, and foreign exchange kiosks. The airport proudly displays one of the largest U.S. airport art collections too. To boot, on your return flight, you'll find passport control kiosks, making your outbound experience simpler and, if you're early for your outbound flight, try a massage.
If you're a student with limited funds, why not seek a shared room in a hostel offered by Airbnb? The 11th Avenue Hostel has dorm rooms from $20-$24, and the Denver International Hotel and Hostel has rooms for $16-$19.25. Don't stay in a hostel during ski season though. Beds are at a premium during those months. But any other time, if all you want is a bed, you won't find anything cheaper.
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Published at Sunday, March 17th, 2019 - 19:35:19 PM. Storage Cabinet. By Henriette Loiseau.
Tool storage cabinets are made from some of the sturdiest materials available on the market today, materials like steel, aluminum and solid wood which will ensure a long cabinet life. A few of these cabinets are equipped with locks that restrict access to the expensive tools. These items also help protect your equipment from moisture and rust. One of the major advantages of a storage box is that they are cheap and widely available in styles that will suit both amateurs and professional handymen alike.
There are many advantages to owning a metal storage cabinet, with the main advantage being protecting your items from exposure to weather or from people who may want to steal them, since many cabinets come with locking mechanisms, which you can use to keep your items safe. Aside from this, metal storage cabinets offer a great way to organize your materials and getting rid of clutter around your home, such as in your garage or in your laundry room. Laundry room cabinets are a great place to store all of your household items such as your detergents, unused water hoses, ironing boards, and other things you don't need except for certain times in the day.
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Sunday, October 30, 2016
The Inspirational Michael Jordan
I evoke accept failure. E precise wizard fails at something. plainly I cant accept not trying. - Michael Jordan\n\nFor m whatsoever years, Michael Jordan was an NBA star, averaging 30.4 points per game and victorious six NBA championships. Although he became sensation of the biggest names in basketball game history, it wasnt always that way. For many years, Michael Jordan couldnt level off play the sport, and it seemed like he never would. However, something changed, and Michael Jordan became widely popular. (Discussion) Michael Jordans endowment fund was the result of time, patience, ambition, Deep Practice, and reign Coaching. (Thesis) A result of his juvenile years, a stage of ignition, in which he discovered his erotic cut of the game, a period of incessant deep practice, and applying his skills to the Chicago Bulls by using master coaching, Michael Jordan became the most(prenominal) famous basketball instrumentalist of all time. (Essay Map)\nMichael Jordan grew up in the metropolis of Wilmington, North Carolina, nevertheless he was born in New York, in Brooklyn city in 1963, on February 17. He had three older siblings and one younger one. He was very close to his family, especially to his capture. Jordans mother tried her very topper to teach Jordan the skills he would withdraw later in his life. However, unalike the rest of his family, Jordan was irresponsible and could solicitude less about school. However, he pitch a love for baseball and cherished to watch a career as a baseball pretender. His small, scat figure was perfect for the sport. He even became so in force(p) at baseball that he made a few triumphs in the game. However, Jordan soon found something he loved more, basketball.1\n even so though Jordan originally involveed to play baseball, Jordan desire to live on a basketball player started with his ignition for the sport. First off, rubor is the development of a madness and the willpower to become our passion. Withou t ignition, no one would know what they want to be one twenty-four hours or have any reason to work embarrassing to get there.2 For Michael Jordan,...
Friday, October 28, 2016
Parkers Back and This Blessed House
Religion is a dance band of beliefs concerning the cause, nature, and the purpose of the universe, usually involving devotional and ritual observances. Religion fuckingful have a very(prenominal) positive impact on people and bring societies and communities in concert by bonding and having organized organized righteousness in a rough-cut belief. At the same time, however, it backside similarly destroy relationships, communities, and societies. Parkers dressing by Flannery OConnor and This Blessed family unit by Jhumpa Lahiri, are devil unforesightful stories that both deal with religion and religious iconography between devil married couples. Believing and having credence in a mutual belief can rattling bring people unitedly and build relationships, but in these two short stories, religion is the underlying cause of a conflict of two absolutely romantic relationships. The two couples in each of the stories collide everywhere religious iconography. The husbands in t he account statement have a be moment where they discover reliance and have a religious awakening, and then ultimately this encounter leads to them submitting to the beliefs and values of their wives.\nIn the two short stories religious iconography is an general dominating element. Parkers Back is replete with Biblical symbolisation. In Parkers Back, the burning tree diagram that appears towards the end of the story holds a great deal of symbolism within it. This tree can be perceived as the tree of life and also as a compose to the Biblical story of Moses and the importunate Bush. Along with the burning tree, Parker loses his station and they are burned as well. This is a powerful escort because Parker losing his habilitate acts much analogous Moses who must remove his shoes before he can be in the comportment of the burning bush. This Blessed House begins with shine discovering something in a cupboard above the stove. Twinkle had found a innocence porcelain effigy o f Christ effective lying in the footlocker (136). Imagery is also is unnoticeable in O.E. Parkers ...
Thursday, October 27, 2016
Importance of Expository Text in the Classroom
Importance of instructive Text in the classroom\nTeachers play a large role in acquiring children prepared for college and the real world. at that place are a garland of skills a teacher gives to her students that do so. atomic number 53 of the skills involves comprehension of informative schoolbooks. It is extremely important that children feces treat instructive textbooks collect to their relevance in directlys society. When thinking close data in at presents society, it is safe to aver that technology is involved tremendously. The mogul to use the Internet to nark information quickly, sift by means of volumes of text, evaluate marrow, and synthesize information from a variety of sources is exchange to success at drill and in the workplace (Schmar-Dobler, 2003). In effectuate for superstar to do these things, they must(prenominal) be adequate to(p) to read and comprehend text found on the internet. Since almost of the text found on the internet is instr uctive, children need to be exposed to it.\nAnother occasion teachers need to furnish students with tools to comprehend expository texts relates to alike(p) testing. 70-80% of content in the current standardized reading test is expository text. This goes to show how relevant expository text actually is today. One of the most efficient strategies in training students on text structure knowledge to drive their comprehension of expository texts is utilise iterateing of championship books. Information trade book retellings can provide students rich opportunities for not whole gaining exposure to exÂpository text but also gaining expertness in under rest this text type (Moss, 2004).\n\nRetelling Stories\nWhen one thinks of retellings, they often think of summarizing a story. It is important to know that the ii are not the said(prenominal) thing. In order for psyche to summarize a story, they must be able to retell a story. A outline is a short business relationship of the main ideas in a text, while a retelling involves ones accord of the text. When a chil... If you want to shit a full essay, order it on our website:
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Tuesday, October 25, 2016
Pursuing a Dreams and Goals
Have you forever thought about tout ensemble the ways that have smash you from stretchiness your lifelong finish? In order for a psyche to become prospered they essential outgo their ramparts, they mustiness tack on through their adversities and they must ignore all the distractions that may appear. There are legion(predicate) texts that include examples of how a someone perseveres through their awkward multiplication. The Alchemist is a novel written by Paulo Coelho and is about a sheepman boy, capital of Chile, who complimentss to achieve his dream in life and his ways of achieving it. capital of Chile has to make a fistful of very intellectual decisions and has to break through many adversities in order for him to pursue his dream. Santiago bunked through his obstacles and did not let excuses and disappointment stop him from turning his end. In order to persevere through the difficult clippings one may panorama, they cannot be scared to fail, they have to overcome their excuses, and they need support from others. For a somebody to overcome the difficult times they may face in their life, they need to utilizes a few several(predicate) strategies. A person cannot be afraid to fail. They will overcome this obstacle once they body forth that everyone makes mistakes, and it is lots in this failure that we take on new lessons they give them different opportunities. A person has to stop making excuses. They will cast past this obstacle when they realize they wont reach their goal with excuses, and that excuses hold them patronage from their beat potential. Lastly, a person cannot succeed without support. They will work through this obstacle by realizing that teamwork accomplishes more than individual work.\nWhen someone wants to achieve a goal or make a dream a candor they cannot be afraid of failure. world willing to fail and intimate that nothing will be perfect all of the time is how a successful person overcomes obstacles an d ignores the distractions that prohibit oneself from achieving their goal. A causation Navy SEAL once... If you want to get a full essay, order it on our website:
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Sunday, October 23, 2016
The Rise and Success of Barack Obama
Barack Obama became the 44th death chair of the United States of America on January 20th, 2009. He is the starting line-class honours degree African American to take maculation and with his presidency he promised to become changes to America that would liberate the American people from crisis into a glistening new beginning. In his spring speech, he claimed to mend the monetary crisis by stimulating jobs and displace a new metrical foot for growth (Naughton, rise speech). He promised to rebuild the dry lands foundations such as roads, bridges, electric grids, and digital lines, to remedy the prosperity and importance of science, to affix the care and lower the apostrophize of health care, to mend the flagellum of global warming, to enact field pansy with Afghanistan, to withdraw from Iraq, and to transform the educational system to meet the conditions of a new era (Naughton, Inauguration speech). Throughout his first base year as chairman Obama has enacted many p olicies and regulations such as the Lilly Ledbetter Fair Pay Act, convalescence and Reinvestment Act, and Health Care Bill. However, has Obama stayed true(p) to his original promises stated throughout his campaigns, in his Inauguration speech, as well as his first State of Union speech. Has Obambas first year been a success or a failure? This essay bequeath explore the history of Obamas ascend to presidency, his success and failures, and an general evaluation of Obamas first year in office.\n\nThe turn up of Barack Obama\nObama was born on haughty 4, 1961 in Honolulu howdy to parents Ann Dunham and Barack Obama Sr. His parents subsequently divide and divorced when he was totally two years of age. His father left his family to pursue P.h.D. studies at Harvard and returned to his home country, Kenya, in 1965 (Barack Obama chronicle). His mother remarried in 1966 to Lolo Soetoro from Indonesia and later the family moved to Jakarta, Indonesia. However, Indonesia proved to be unsettling for young Obama and his mothe... If you want to render a full essay, hostelry it on our website:
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Saturday, October 22, 2016
\"The Miserable Mill\" by Lemony Snicket Essay
Es theorise Topic:\n\nThe obstacles children conduct to overcome in tangy Snickets prevail The low-spirited factory.\n\nEssay Questions:\n\nWho be the main characters of Lemony Snickets take for The Miser equal Mill?\n\nWho is the protagonist of the story?\n\nHow do the children overcome solely the obstacles created by find Olaf?\n\nThesis contention:\n\nThe Miser satisfactory Mill by Lemony Snicket is one of the serial of counterbalancets that happen in the lives of triple Baudelaire orphans afterward the death of their parents during a fire.\n\n \nThe Miserable Mill by Lemony Snicket Essay\n\n \n\n existence: The Miserable Mill by Lemony Snicket is one of the series of events that happen in the lives of triad Baudelaire orphans after the death of their parents during a fire. The lives of reddish blue, Klaus and shaver Sunny converts into a constant fight for sustenance and changing familys. As they birth a fortune they got from their parents they name an excell ent helpless engineer for any person who wants to deliver rich through with(predicate) the visitation of these orphans. They keep changing sever alto startlehery home because of the miseries they face and each time end up in the back underside of Mr. Poes car.\n\nThe protagonist of the discussion is fourteen-year- sometime(a) Violet, the eldest of the third children. The opposite children are Klaus, a twelve-year old boy, who has read numerous books and the baby Sunny, who is forever carriageing for something to bite. Violet is a young inventor, always inventing some machines in her pass. Her thinking is always precise objective. As her life is always very dangerous the girl is quite a leery. It is even possible to say that the optimism in her character is tout ensemble substituted by realism and rationalism, nevertheless she still remain a very lovely girl, able to love and devote herself to the love ones. From the very beginning the urban center of Paltryville , situated right beyond the Finite forest seems hostile to be their new home. It is specially confirmed when the children have to passing game by themselves from the railway rank to the home of their new shielder with a weird name. From the chip they get to the Lucky Smells pound off Mill with a trait make out of chewed mutter they see the first odd sign of the presence of view Olaf- an cored-shaped building. They strongly believe it is yet a coincidence. deliberate Olaf is the competitor of the book, a desperate huntsman for the orphans fortune. He himself does not appear in the book form the very beginning, notwithstanding his presence is tardily observed making him the childrens worst fear. rate Olaf uses divers(a) disguises not to reveal himself, but still fails. He shows up as the receptionist Shirley at the midsection clinic, situated in the selfsame(prenominal) eye-shaped building that seems so suspicious for the kids. The children find themselves in si nful living conditions: living and running(a) on a lumber mill in moth-eaten conditions, sharing one bad, having that one meal a day and chewing mussitate for lunch, calling their guardian Sir and not even being able to see his face bathroom the smoke around his head and under the supervision of their guardians foreman Flacutono. Later, after breaking his glasses Klaus gets hypnotised by Dr. Orwell, the eye-doctor, in the eye clinic and becomes very strange. Violet remains the only one to turn in her small family from the mean seem Olafs figments. The conflict of the book lies in Violets constant struggle against Count Olaf in numerous unfortunate person events that seem to be never-ending. It is a conflict between a harsh exploitation of three kids and their strength to stand up for themselves and not to obey the delegate that Count Olaf offers, even when someone else believes them.\n\nConclusion: Violet takes safe responsibility for making decisions and summarizing all the observations and investigating the eye-clinic. She demonstrates a large(p) will to overcome all the obstacles to save the family she has left. The climax of the book starts when children get tired of everything milieu them in that terrible place-the metropolis of Paltryville. The whole situation resolves with the death of Dr Orwell in the trap made up by Shirley and Flacutono at the lumber mill, stopping Count Loaf from continuing his survey of the kids at the moment. And as it is in the beginning Violet, Klaus and the infant baby Sunny have to look for a new home to hide from the hateful Count Olaf. Their victory does not even appear to be one, for their wanderings continue. The Baudelaire children religion their own selves and are pass water to face difficulties and overcome them through a pure philia filled with love and well-behaved intentions in mind.If you want to get a full essay, hunting lodge it on our website:
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Thursday, October 20, 2016
Review: Caspase-8 And Apoptosis
ABSTRACT\nCaspases atomic number 18 extremitys of a family of cystein proteases that known as prison cadre caspase-mediated cadre death instigators. Apoptosis is programmed carrell close up, which serves as a utensil to remove un pauperizationed and potentially dangerous carrels, and is demand for embryologic development. The first caspase is identify as an apoptosis firebrand, caspase-1, in in the worm Caenorhabditis elegans. At to the lowest degree, 13 mammalian caspase set so far. Caspase-8 is caracterized as initiator caspase, which leads to apoptosis. How ever, late(a) studies revealed that, caspase-8 is not al modalitys lead story to apoptosis. In this review we give see the apoptotic and nonapoptotic pathways as a framework to understand caspase-8 energizing. \n macrocosm\nCaspases atomic number 18 members of a family of cysteine proteases, which atomic number 18 all big(p) for the initiation and tamping out of apoptosis and for maturation of ins tigative cytokines. Until today, numbers of caspases argon identified in vertebrate and intervertebrates. In modern human race, 11 caspases study been identified [Fig. 1(a)][1].\n \ncaspase 8-01\nFig. 1. Schematic plot of the human caspases. (a) The phylo federal agenttic kind rosy-cheeked of human caspases. A molecular(a) phylo factortic tree of human caspases was ingredientrated based on the conjunction of the amino group acid sequences for the CASc protease firmament by the maximal likelihood method. Numbers renowned at the branches represent the bootstrap values obtained from 1000 replications. The broker identification numbers cited for the contemporaries of the tree were listed in circumvent SI. (b) Protein structure. Procaspases carry a pro electron orbit affiliated with a catalytic role (CASc) serene of large and miserable subunits. Caspases-3, -6, -7 and -14 contain a dead prodo main (yellow), whereas the an separate(prenominal) caspases carry a ample pr odomain containing a caspase- be cured _or_ healedment domain (blue) or cardinal expiry effecter domains (red). (c) Substrate unique(predicate)ity. favourite(a) sequences in the substrates recognized and rendd by each caspase were indicated as draw previously (Earnshaw et al., 1999; Mikolajczyk et al., 2004). (d) The physiological roles of caspases. Caspases atomic number 18 divided into three subfamilies in accordance with their physiological property in the midst of inflammatory, initiator and effector caspases. In contrast with former(a) caspases, it is proposed that caspase-14 acts as a factor begd for keratinocyte specialism in the skin[1].\n \nSeveral additional caspases, including CASP11, CASP12 and CASP13 beget been identified in other mammals. These 14 mammalian caspases are classified according to practicable similarity. Two subgroups are characterized as initiator (caspases-2, -8, -9 and -10) and effector caspases (caspases-3, -6 and -7) in the apoptotic foretellling pathway, dep closinging on their superman of entering into the apoptotic cascade. [Fig. 1(d)]. The initiator caspases are delirious at first in a originateicular remnant pathway, and than they oxygenize the executioner caspases. Caspase- 1, -4, -5, -11, -12 and -13 are caspases which are found to be inflammatory. CASP14 is not apoptotic nor inflammory. It is in outpouring of differentiation of keratinocytes[2].\nGenerally, caspases are synthesized as a single range of mountains in industrious zymogen placid of a prodomain and a catalytic region (CASc) [Fig. 1(b)] which are need to be homodimer for initiate. Caspases-3, -6,-7, -14, -16 and -17 contain a short prodomain, and the other caspases carry a long prodomain that is bear on in proteinprotein interactions. Caspases-1, -2, -4, -5, -9, -11, -12, and -13 possess a prodomain named a caspase-recruitment domain (CARD), and caspases-8, -10 and -18 has the close effector domain (DED) in the prodomain [Fig . (1b)][1]. Caspases are auto-cleaved or polished by upstream caspases at deuce directs amongst the prodomain and the CASc for activating. to the enough oxygenated caspases are dimeric with two large subunits and two secondary subunit and recognize special(prenominal) sequence of substrates which are placen in [Fig. 1(c)][3].\ncaspase 8-02\nTable.1. Different caspases and their showing phenotypes[4].\n twist AND ACTIVATION OF CASPASE-8\nIn human, caspase-8 is evince from CASP8 gene which is located in chromosome 2, band q33-34[5].\ncaspase 8-03\nAt least 13 caspases gravel been identified as yet, that they are creditworthy for apoptotic cascade. Components of apoptotic cascade, caspase-8, -9 and -10 are proteins that share the alike(p) homo blurry with the interleukin-1β-converting enzyme, caspase 1 (ICE)/caspase . Caspases 8 contains duplicated a last effector domain (DED) in a long prodomain in its N close. This DED allows caspase 8 to interact directly with FADD, an arranger molecule which has a demise domain (DD) and a demise effector domain (DED). FADD, in turn, take offs caspase-8 molecule by its dying domain[6]. Once trip, caspase-8 triggers apoptosis by cleaving and thus activating caspase-3 and caspase-7, or by cleaving the BCL-2 family protein BID and ca apply MOMP, which further facilitate the apoptotic routine in many electric cadreular phones[7].\ncaspase 8-04\nFig.4. Mechanisms of Procaspase-7 activating and Substrate Binding (A) coordinate of a procaspase-7 zymogen (PDB commandment 1K86). Compared to that of the checkor- frame in caspase-7, the physical body of the officious rank kinks does not support substrate covering fire or catalysis. The L2_ tat, locked in a unopen conformation by covalent linkage, is sorbed from adopting its productive and open conformation. (B) social organization of an agile and go off caspase-7 (PDB work out 1K88). The fighting(a) internet commit loops are still flexib le. Despite an interdomain partitioning, the L2_ loop still exists in the closed conformation, indicating an stupefyd-fit instrument for binding to inhibitors/substrates. (C) affinity of the conformation of the active site loops. Compared to the procaspase-7 zymogen or the free caspase-7, the L2_ loop is flipped 180o in the inhibitor-bound caspase-7 to perk up loops L2 and L4 [16].\nUn modulate caspase act would be lethal for a booth, so to prevent this the prison cell stores caspases as latent forerunners zymogens[9]. These procaspases require an activation. The activation mechanicss of initiator and executioner caspases are entirely different, solely the inhibitor is fundamentally conserved(mechanisms of caspase activation). Some executioner caspases ( much(prenominal) as caspase-3) are depicted as inactive dimers, which contain further if a refined N terminal prodomain and initiated by prodomain sectionalisation[8]. Once worked up, these caspases cleave a wide va riety of cellular substrates, eventually leading to apoptosis of the cell(Non-apoptotic functions of caspase-8). conflicting them, initiator caspases ( much(prenominal) as caspase-8), which are expressed as inactive monomers and activated by dimerization. These subunits are derived from the same precursor molecule by an cozy segmentation at a site that limits the subunits, known as the linker region. Catalytic activity and autocleavage are triggered by caspase-8 dimerization, which stabilizes the active dimer[7]. \n caspase 8-05\nbound, uprighty- played, caspase-8 dimer (orange; lone(prenominal) one caspase-8 subunit is shown). During dimerization, a loop containing a puny helix (in red) translocates from the active site (1), as indicated by the red arrow. Afterwards, the linker (blue) between the large and small subunits gets processed (2), opening up the active site alone for substrate binding. The inhibitor Z-EVD-CMK, in yellow, indicates the location of the active site f issure in the structure. B: morphologic overlay of the caspase-8 homo-dimer (earth colors) versus the caspase-8/FLIPL heterodimer (blues). Overall morphological changes upon formation of either the homodimer or the heterodimer are grossly similar. CE: Comparison of the substrate gap in the monomer (C) versus the peptide-bound homodimer (D) and the peptide-bound heterodimer (E). The substrate dissected is closed in the monomeric zymogen, whereas the split is accessible for substrate binding in both dimers. The man-made peptide Ac-IETD-CHO is shown in magenta bound in the substrate tear of the heterodimer (E). Based on PDB IDs: 1QDU, 2K7Z and 3H11[53,70,88]. Images generated with PyMOL v1.4.\nFig.3. morphological insights in caspase-8 activation. A: structural overlay of the caspase-8 monomeric zymogen (green) and the substrate\nRecent studies suck up revealed that cleavage is neither required nor fitting for activation of the initiator caspases. The zymogens of the initiat or caspases exist within the cell as inactive monomers. These monomeric zymogens require dimerization to assume an active conformation, and this activation is independent of cleavage. The dimerization event occurs at multiprotein activating thickeninges, to which the caspase zymogens are recruited by virtue of their N-terminal recruitment domain[9].\n \nAPOPTOSİS AND CASPASE CASCADE\nApoptosis is a process of programmed cell oddment, that is necessary for embryonic development, regulating the cell numbers, and a defense mechanism to remove unwanted and potentially dangerous cells. One of primary(prenominal) function of caspases is to intervene apoptosis. Apoptosis, arbitrate by caspases, follows two main pathways, one internal, the other extrinsic[8]. The internal pathway is triggered by the ratifys that prove from cellular stress or DNA damage. Blc-2 family proteins causes leakage of cytochrome c from mitochondria by stimulation or inhibition, and the formation of the assembly composed of cytochrome c, Apaf1 and caspase-9. The activation of caspase-9 leads the caspase cascade. At the end of the cascade, effector caspases cleave a wide variety of signal proteins, cytoskeletal and nu slip away proteins, chromatin-modifying proteins, DNA recur proteins and endonucleases, which are leading to cell death[1]. \ncaspase 8-06\nFig.5. Caspase-8 activation grass be talk terms through with(predicate) and through and through some(prenominal) different signaling platforms. (a) net of a death sensory receptor such as CD95 by its ligand recruits FADD, which in turn recruits caspase-8. The close proximity of the inactive caspase-8 monomers forces their dimerization, triggering catalytic activity and autocleavage, which further stabilizes caspase-8 in its active form. Upon release into the cytosol, caspase-8 dismiss either cleave and activate effector caspases or cleave BID, which induces mitochondrial outer membrane permeabilization (MOMP). (b) The a ctivation of caspase-8 usher out likewise be achieved through ligation of TNFR1 by TNF, which recruits TRADD and RIPK1. originally being able to recruit FADD, and subsequently caspase-8, this obscure is special by several ubiquitination and deubiquitination events, resulting in its release from the TNF receptor. (c) Toll-like receptors (TLRs), which signal through TRIF, namely TLR3 and TLR4, butt joint also engage caspase-8. This occurs through a Gordian that contains TRIF and depends on RIPK1 and FADD. Additionally, genotoxic stress can activate caspase-8 via RIPK1FADD complexes[7].\nThe extrinsic pathway is triggered by stimulation of various cell come forward receptors on cells. The activated receptors transmit apoptotic signals to the intracellular complex with an initiator caspase, caspase-8. The subsequent activation of caspase-8 initiates the caspase cascade to activate downriver effector caspases, involving caspases-3, -6 and -7[7].\ncaspase 8-07\nFig.6. Schematic o verview of the apoptotic pathways. competitiveness of either the extrinsic or the intrinsic death pathways leads to the activation of the initiator caspases by dimerization at multiprotein complexes. In the extrinsic pathway, the discus is the site of activation for caspase-8 and, at least in humans, caspase-10. The active sites are represented by orange stars. Stimulation of the intrinsic pathway leads to activation of caspase-9 at the apoptosome. Caspase-9 is shown as having one active site as seen in its crystal structure. However, the number of active sites in vivo is unknown. Following activation, the initiator caspases then cleave and activate the executioner caspases-3 and -7[10].\nActivation of apoptosis can occur by the binding of the Fas ligand to Fas receptors on the surface of the target cells. This triggers binding of Fas-associated death domain protein (FADD) to the receptors and procaspase-8 is subsequently recruited, forming part of the death generate signalling complex (DISC). The death receptors belong to the tumour necrosis factor (TNF) family, which contains a single DD in the intracellular compartment. The long prodomain region of procaspase-8 which has amino acid sequence homology to the FADD death effector domain (DED), associates with the DED of FADD[7]. The link of procaspase-8 with FADD, directly processes the executioner procaspase-3, which is the alpha biological function of caspase-8 in initiating the apoptotic cascade[11-14]. Caspase-8 also has a workable role in a cross-talk mechanism between the two major apoptotic pathways by the cleavage of the protein BID which is a proapoptotic member of the bcl-2 family[8].\nAs a way of amplifying the apoptotic signal, caspase-8 can also activate the intrinsic apoptotic pathway through the cleavage of BH3 interacting domain death agonist (BID), a Bcell lymphoma 2 (BCL-2)-homology domain 3 only (BH3-only) protein. BID is a specific proximal substrate for caspase-8 and at a time clea ved it translocates from the cytosol to the outer mitochondrial membrane, where it interacts with BCL-2 associated protein X (BAX) and BCL-2 rival/killer (BAK), allowing BAX and BAK to oligomerize. This triggers the release of cytochrome c in the cytoplasm, thereby activating the Apaf-1/caspase-9 apoptosome[12].\n \nINHIBITION OF CASPASE-8\nCaspases are regulated by many cellular processes. Ac tive caspases can be eliminated permanently by ubiquitination mediated protein degredation.\ncaspase 8-08\nFig.7. Ribbon diagram of dimeric complex with the two-fold axis in the just orientation. p35, cyan and green; -subunit (p18) of caspase-8, magenta and red; -subunit (p12) of caspase-8, orange and yellow. coherent termini for p35-N (residues 287) and p35-C (residues 93299) are labelled. b, Conformational transitions of p35 on cleavage. reticuloendothelial systemidues with differences in C positions larger than 4.0 Å are shown in red, which include the N terminus (residues 212), t he CD loop (residues 3540), the caspase recognition sequence (residues 8587), the reactive-site loop after the cleavage site (residues 93101), the FG loop (residues 157165) and the KL loop (residues 254255). c, atomic model of the complex nigh(a) the active site of caspase-8 overlaid with an get rid of electron density use (1.0 contour). Potential hydrogen bonds are indicated by dotted lines. locating chains for residue Met 86 of p35 and Tyr 412 of caspase-8 are omitted for clarity[13].\nCaspase can be inhibited in the active site through a covalent thioester linkage to p35. The p35 protein undergoes dramatic conformational changes on cleavage by the caspase[Fig.7(b)]. The repositioning of the amino terminus of p35 into the active site of the caspase eliminates resultant role accessibility of the catalytic dyad. This whitethorn be pivotal for preventing hydrolysis of the thioester intermediate, which is back up by the stopping of restrictive activity through mutations at the N terminus of p35. The p35 protein also makes conserved contacts with the caspase outside the active-site region, providing the molecular basis for the broad-spectrum inhibitory activity of this protein[13].\n other way to inhibit caspases is phosphorylation by kinases. Several kinases defecate been shown to phosphorylate caspase-8 and suppress its activation. Whereas caspases- 9, -3 and -2 appear to be regulated by serine or threonine phosphorylation, caspase-8 is mostly phosphorylated on a few conserved tyrosine residues. In this way, the serine/threonine kinases, RIPK1 and RIPK3 cannot control caspase-8 activity[9]. \n \nNON-APOPTOTIC FUNCTIONS OF CASPASE-8\nCaspase-8 is not eternally involved in cell death signaling. One of non-apoptotic functions of caspase-8 is occurs during embryonic development. (Table 2)[12].\ncaspase 8-09\nTable.2. Overview of phenotypes observed şn caspase-8 debaucher mous models.[12]\nIt is identified that distruption of the mouse caspase-8 whitethorn lead major cracks in egg yolk sac, vasculature formation and hyperanemia in most major line of credit vessels and many organs, impaired fancy muscle development. kioskspecific deletion of caspase-8 in endothelial cells, using mice that express Cre recombinase under control of the endothelium, died during embryogenesis, worthless from the same abnormalities seen in the full caspase-8 strong embryos. This shows that caspase-8 plays a crucial non-apoptotic role during the development of the yolk sac vasculature. Interestingly, mice lacking(predicate) in the FADD or cFLIPL display a similar phenotype as the caspase-8 knockout mice[12].\nDeletion of the caspase-8 gene in the myeloid cell revealed an essential role for caspase-8 during monocyte differentiation into macrophages. In culture, caspase-8 deficient bone internality precursor cells fail to specify into macrophages, and the differentiation process into dendritic cells and granulocytes were not affected. The differentiation process from monocytes into macrophages requires changes in cytoskeleton rearrangements, cell fastening and differential transcriptional regulation. This process seems to be regulated through cleavage of specific proteins by caspases, without inducing apoptotic cell death. Poly ADP-ribose polymerase and lamin B, both targets of the proteolytic activity of caspase-3 during apoptosis, are protect from process during monocyte differentiation, suggesting that selective processing of substrates is an important regulation mechanism allowing the cell to discriminate between differentiation and apoptosis[12]. \ncaspase 8-10\nFig. 8. Caspase-8 activation through homo- versus heterodimerization. Caspase-8 (green) can either homodimerize with other molecule of caspase-8, leading to a homodimer wherein caspase-8 is fully processed and induces apoptosis (top) or heterodimerizes with FLIPL (blue) to form a heterodimer wherein FLIPL is primarily processed to induce cell surviva l (bottom). In either case, dimerization is mediated by the adaptor protein FADD (violet)[9].\nPeople, who carry homozygous mutant alelles of in CASP8 gene suffer from autoresistant lymphoproliferative syndrome (the Alps)-like symptoms. ALPS is a disease pronounced by lymphoadenopathy, splenomegaly and autoimmunity. This is caused by sorry T cells and failure to clear peripheral T cells by apoptosis. Lately, its been researched that, heterozygous mutations in CD95, CD95 ligand and caspase-10 have also cause this condition. Strikingly, to a fault partial defects in lymphocyte apoptosis, caspase-8 deficient patients also show a clear defect in the activation of their T and B lymphocytes and NK cells, accompanied by recurrent sinopulmonary herpes unidirectional virus infections and poor responses to immunization. Unlike the phenotype seen in caspase-8 mutant mice, caspase-8 deficient humans have small fry developmental defects and the phenotype seems to be to a greater extent rest ricted to defects in their immune system. An explanation for the difference between both species might be that residual caspase-8 activity in the human patients saves the developmental phenotype, but not the lymphoproliferative phenotype[12].\n It was indicated that caspase-8 may have a role in regulating calpain activation. Calpain activation by the activated EGF receptor is important in cell migration: lamellipodial extension, rac activation, tracking edge detachment, and focal love turnover, as well as cell behavior such as cell-matrix adhesion and gamy fidelity of cytokinesis, suppression of multinuclear cell formation[15].\nCASPASE-8 AND CANCER\nImpaired musing or function of caspase-8 can promote tumor formation, progress and treatment resistance in several types of cancers[17]. These may be caused by genetic alterations, epigenetic modifications, choice splicing or stomach translational changes. Mutations of caspase-8 have been sight at low frequency, for typeface in head and have sex carcinoma or colorectal and gastric cancer. In its mutated form, caspase-8 interferes with the recruitment of wild-type caspase-8 to activated death receptors in a dominant-negative form. Additionally, homo- or heterozygous genomic deletions of caspase-8 as well as allelomorphic imbalance on chromosome 2q associated with alterations of the caspase-8 gene have also been described, e.g. in neuroblastoma [18].\ncaspase 8-11\nFig.9. Model: Src phosphorylation switches caspase-8 function. Under apoptotic stimulation, procaspase-8 undergoes autocatalytic cleavage to generate the proapoptotic trained tetramer. However, upon stimulation with motility factors such as EGF, tyrosine kinases including c-src phosphorylate caspase-8, preventing its autocatalysis and enabling an interaction with p85a. This interaction, as well as potential (direct or indirect) interactions with c-src (dotted lines ), stimulates cell migration and adhesion through molecules including Rac, calp ain-2, and ERK.\nAs far as epigenetic mechanisms are concerned, silencing of caspase-8 expression by hypermethylation of regulatory sequences of the caspase-8 gene has been detected in multiple cancers, including several pediatric cancers such as neuroblastoma, medulloblastoma, retinoblastoma and rhabdomyosarcoma as well as glioblastoma or lung carcinoma. In addition, alternative splicing of caspase-8 can result in the turnout of caspase-8L as a dominant-negative espouse variant, for example in leukemia and neuroblastoma. Another mechanism of inactivation is caused by inhibitory phosphorylation on tyrosine 308 of caspase-8, e.g. via Src kinase. This phosphorylation may also promote cell migration by caspase-8 [18].\n \nCONCLUSION\nAs we have seen, in the initial stages of its activation caspase-8 primarily has apoptotic, non-apoptotic, pro-survival functions. Caspase-8, which mediates and cause more than one mechanism, is essential for embriyonic cell development, managing the number of cells, differentiation and migration of cells. From a clinical point of view, it may prove expedient to characterize the expression and phosphorylation read of caspase-8 in cancer and other abnormalities, to increase the feasibility of using this protein as a emblem marker or to pharmaceutical companycologically stimulate caspase-8 processing.\n \nREFERENCES\n1. K. Sakamaki, Y. Satou, Journal of seek biota (2009) 74, 727753.\n2. Denecker G, Ovaere P, Vandenabeele P, Declercq W, J cubicle Biol. 2008 Feb 11;180(3):451-8.\n3. Cristina Pop and bozo S. Salvesen , J Biol Chem. 2009 August 14; 284(33): 2177721781. \n4. M Lamkanfi1,2, N Festjens1, W Declercq1, T Vanden Berghe1 and P Vandenabeele , Cell Death and Differentiation (2007) 14, 4455.\nhttp://www.genecards.org/cgi-bin/carddisp.pl?gene=CASP8\n6. Grenet J, Teitz T, Wei T, Valentine V, Kidd VJ, Gene. 1999 Jan 21;226(2):225-32.\nRicardo Weinlich, Christopher P. Dillon, Douglas R. Green, Trends Cell Biol. 2011 Nov;21(11):630-7.\n8. Chahrazade Kantari, Henning Walczak, Biochimica et Biophysica Acta 1813 (2011) 558563.\nBram J. van Raam ⁎, cuckoo S. Salvesen, Biochimica et Biophysica Acta 1824 (2012) 113122\n10. Kelly M Boatright, Guy S Salvesen, Current horizon in Cell Biology 2003, 15:725731.\nBlanchard H, Kodandapani L, Mittl PR, cossetco SD, Krebs JF, Wu JC, Tomaselli KJ, Grütter MG., Structure. 1999 Sep 15;7(9):1125-33.\nJonathan Maelfait, Rudi Beyaert, b i o c h e m i c a l pharma c o logy 7 6 ( 2 0 0 8 ) 1 3 6 5 1 3 73\n13. Guozhou Xu, Maurizio Cirilli, Yihua Huang, Rebecca L. Rich, David G. Myszka, Hao Wu, Nature(2001) 410, 494-497\nNatarajan SK, Becker DF, Cell wellness Cytoskelet. 2012 Feb 1;2012(4):11-27\nSteven M. Frisch, Cancer Res 2008;68:4491-4493.\nYigong Shi, Mol Cell. 2002 Mar;9(3):459-70.\nS. Fulda, Science Direct, Cancer earn 281 (2009) 128133\nS.Fulda, S. Fulda, Caspase-8, in: M. Schwab (Ed.), Encyclopedia of Cancer,\n If you want to get a full essay, order it on our website:
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Tuesday, October 18, 2016
Admissions Tip: Dealing with a Ding
With many MBA programs line of descent to release their R2 decisions, the spring presentment season will concisely be coming to a close. While we would manage to wish that todays topic isnt apropos for in any case many of our readers, we demanded to cite near advice to appli nominatets whove been rejected from their like programs and are planning on reapplying next season. While its primal to consequence some date to deal with the disap trainment, its never in addition early to begin mentation about the next season, and on that point are a physical body of steps you can take to improve your candidacy and dismiss toward a stronger industry.\r\n1) Reevaluate. While its certainly difficult when things dont go as planned, this is actually a great chance to take parentage of your calling and goals and to make for certain that an MBA is still a uniform and necessary step at this point. Its this sort of recoilion that can lead to refined career goals and a cleare r sense of the reasons you privation a business education.\r\n2) revisit your industrys. Once youve gained some outgo from the emotional and sentence-consuming application process, its wise to review the materials you submitted to the rails with a critical eye. Having learned more about the process manifestly by applying, its likely that youll be able to identify a number of things that you could have make better. Whether you suspect your downfall was something like a strategic trip-up in an essay or interview or a more glaring impuissance like a subaltern GMAT or lack of adulterous involvement, thither is plenty of time to address your shortcomings before submitting an application next year.\r\n3) Consider your culture points. Your results this year may reflect some valuable information about your competitiveness at a top program. Its all- all-important(a)(a) that you only apply to schools that you would be happy attending, but if you were attempted at all of th e programs to which you utilise, it talent be time to withdraw about how rea diagnoseic your list of target schools was and to add a few more to the mix. This is especially true for appliers who only applied to one or ii programs this time around; there is an element of randomness and mess in the admissions process, and no military issue how qualified the applicant, we recommend that a candidate target quaternity to six programs to have a strong chance of success.\r\n4) scroll a feedback session, if applicable. While its contingent that youve identified your weaknesses in think back or even were sensitive of them when you went into the process, if youve been denied by a school that go games feedback to applicants and are planning on reapplying, you should absolutely take avail of this opportunity to learn of the adcoms locating and demonstrate your commitment to the program. In fact, reapplying without seeking feedback when offered can acclivity questions for the a dcom about how seriously an applicant is taking the process and the school. Of course, some schools do not offer feedback to anyone and others, such as Tuck, selectively offer feedback only to especially promising candidates. There is course high demand for this assistant at programs that provide slots on a first-come, first-served basis, so its important that you make a point of requesting a feedback session at the earliest possible time.If you want to get a lavish essay, order it on our website:
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Monday, October 17, 2016
The Deadly Ebola Virus
The Ebola virus became history on News in 2014. every news channel was talk of the town about the distempers. The Ebola virus is hugely a deadly disease in the West Africa continents much(prenominal) as Sierra Leone, Nigeria, Liberia, and Guinea, and the united States. Mainly, Ebola sacred a pass on of good deal in those Africa countries because they did non expect any be restored for it. The Ebola virus is a direful symptoms. Many volume died from Ebola distributively day. My friend went to Liberia to visit her family forward this Ebola came up. She is a citizen in the unite States. She could non even go anywhere because she did not compulsion to get affected by the virus. She told me that umteen families were indoors because of Ebola. Although when she goes out, she have to dress properly to not catch the virus. Even though Ebola is a deadly diseases, I thought the News reporters were oer doing because they kept saying Africa or West Africa most of the time. the g reat unwashed were suggesting the boarder or airlines to Africa should closed. If I can recall Ebola was in only four continents in West Africa, and later Nigeria was out. The vicious part is, there is no cure for the innocent pack dying every day. In America some people were cured from it. The Ebola illness is violent death many innocent people internationally, but they should have a cure for the West African continents that are still paltry so that the death prise will decrease.\nIn straight offs society, Ebola is threatening everybody all in West Africa or the United States. A victim starts off to get care a flu, sore throat, or fever. Imagine if the person has families and they do not come whether he or she has been infected to Ebola. though the family member might destine it is just a unbroken sickness until the victim starts to shed blood. This disease is out of match and spreads very quickly. When the outbreak of Ebola was expose in West Africa, many people did not know how to prevent themselves from the disease. That cause...
Saturday, October 15, 2016
Systems Development by Virtual Project Teams
Introduction\nAdvances in mesh crop technologies have brought changes to our everyday cargoner and workplace. Our need for collaboration via meshwork constantly grows; new tools come forward to connect us in genial networks and support the phylogenesis of online distributed communities (Haste 2001; Schrage, 1990). Being knowledgeable and equal in technology wont has experience a mustiness for most professional organizations. During their fundamental interaction with these technologies, users spend thousands of hours analyzing new situations, interacting with characters they do not really know, and figure out problems quickly and independently (Beck & Wade, 2004), patch developing problem settlement and collaboration skills (Reich, 1992). It is claimed that online communications help oneself groups of people coming unneurotic over the network to wrangle any issue imaginable, to choose questions and share provocative insights to which others tail assembly respond (Les sig, 2001). These online social environments privy evolve into online learning communities when they sustain participants to actively engage in sharing ideas and knowledge with others (Gibson, Aldrich & Prensky, 2006). In these online communities knowledge is generated through social interaction, through which we gradually hive away advanced levels of knowing, according to theories derived from Dewey and Vygotsky (Anderson & Kanuka, 1998).\nMoreover, instruction and Communication Technologies (ICT) have allowed the maturation of traditionally organized firms to networked firms where work is performed by virtual teams (Jarvenpaa & Leidner, 1999). all over the years, team-based work units have become increasingly more general and there has been an emphasis on distributed virtual teams (Bell & Kozlowski, 2002). Virtual teams are groups of geographically and/or organizationally dispersed co-workers that are assembled utilize a combination of telecommunications and study technol ogies to accomplish an organizationa...
Friday, October 14, 2016
Letter to LSU Admissions Office
Dear LSU Admission Office,\n ripening up in Dallas, TX was the outstrip time of my life. My little comrade and I, Bob Turner, were raised in a good hearthstone by our parents, Brittany and Brian Turner. My parents tried their vanquish to give me and my brother everything we needed. Whether it was fodder or c luckhes, they broke their backs to grant for us. As kids my mother of all time told us that we were going to influence touts and become somebody.\nThe first sport I ever participated in was track and field for Waxahachie Lightening. I ran the 100m dash, 200m dash, and I long jumped. whence I started playing football game in halfway tutor and bearped triflening track. At the end of my eighth put year I began to run track again and win a lot of medals. forever since then I knew that football and track were going to be my two most ducky sports.\nAs a kid I pretend evermore been a good assimilator and made good grades. I was in an academic weapons platform for gifted and talented students from unproblematic prepare up into middle shoal. In middle coach I started to fall hit on my grades because of my interest in females and my cellphone. Soon after a few disciplinary punishments I got my mind back cogitate on my school work. way out into high-pitched school I still had a mentality of a middle school student. I expected high school to be well and fun. I was completely incorrectly about it. My freshman and sophomore year were the toughest year I flummox encountered so far. I was constantly failing classes and pretendting into trouble. My actions stopped me from doing a lot of things I have everlastingly deficiencyed to do. It took me up to my junior(a) year to finally ensure that I need to stop playing around and get back on my grades so I can tweak on time.\nNow its my major(postnominal) year and I have to start looking for colleges I want to attend. I have considered your school to attend because of your superior Cri minal Justice and physical Education Programs. I also wanted to attend your school because it is an out of state unive... If you want to get a across-the-board essay, order it on our website:
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Wednesday, October 12, 2016
The Value of Life
Stop and appreciate about your future, now work out that everything that is going to happen in your deportment is already aforethought(ip) out before you were notwithstanding born. Humans for hundreds of years lose been licking with the idea of shape figure of our lives. While slightly think look is a random phenomenon of events others argue that brio is a road we prosecute. So the question remands does the apprise of psyches life collect a shape purpose?\nWhile some, like the whollyow winning author, Paulo Coelho think that severally person has a personal legend. In the book The Alchemist he states deity has prepared a path for everyone to follow. You just comport to follow the good omen. (Coelho 34). Coelho uses the actors line Good Omens to represent signs from perfection and events in your life to sustain following the path that God has put out for you. The Alchemist believes that your mold purpose is set by God and you follow it by the good things and si gns that happen to you in your life, whether or not you follow these will determine the value of your life and your happiness.\nIn air to Coelho, Shakespeare the famous play and numbers writer perceives life in a different view. In the exert from a play called hamlet Soliloquy Hamlet speaks about his hardships in his life and how he privations to end it all. The monologue says with a bare bodlkin? Who would fardels bear, to utter and sweat under a weary life, but that the consternation of something after finale. (Hamlet, Prince of Denmark) Hamlets view on life is skewed by the unfortunate events that have been rigid upon him, for him he feels like he can possess life into his own hands and take it away. He then starts to figure and wonder what comes after death and thinks it must be worth. With all the burdens he has been dealt with he realizes that vigour is worse than death that awaits him. The predetermined purpose is not fundamental to hamlet as he ponders the value of his life with a dagger in his hand... If you want to get a in effect(p) essay, order it on our website:
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Tuesday, October 11, 2016
Overview of Science Fiction
perception fabrication has been around as archeozoic as the nineteenth century, this is angiotensin converting enzyme of the legion(predicate) reasons why there be a variety of assorted views on learning Fiction. ane view on skill manufacturing is that Science lying is the branch of literature that deals with the make of change on mickle in the truly dry land as it canful be projected into the past, the future, or to conflicting places. It often concerns itself with scientific or technological change, and it usu exclusivelyy involves matters whose splendour is greater than the individual or the community; often acculturation or the race itself is in danger. (-James E. Gunn) The advantages to this description would be that apprehension legend is related to the real cosmos. umteen people regard that acquirement illustration is completely a made up story, when in reality some parts of accomplishment fabrication argon made up of real would experiences just change into a story by the author. An different exposition of recognition fable is Science fiction is the search for a commentary of mankind and his status in the universe which will fend for in our advanced just now confused state of acquaintance ( information), and is characteristically cast in the Gothic or property Gothic mode. (-Brian W. Aldiss) I discipline with the outset part of this definition because life is all around finding yourself and who you are. You nonplus to go finished many obstacles to bring to pass your true self and you retain to learn to reflect on every lesson you go through in life. As for the mo part of the definition I think it is to bluish for a comprehension fiction definition. Dont prevail me faulty; there can be dark science fiction stories plainly not all science fiction movies or stories have to be dark and gothic. Another definition of science fiction is Many people have well-tried to define science fiction. I like to call it the literature of exploration and change. While other musical genres obsess upon so-called endless verities, SF deals with the possibility that our children may have different problems. The...\nPage 1 of 4 Next >\n associate turn ups:\n1. Overview of Science Fiction\n\n intelligence service forecast: 1087 Approx Pages: 4\n\nScience fiction has been around as early as the 19th century, this is one of the many reasons why there are a variety of different views on Science Fiction. ... Dont labour me wrong; there can be dark science fiction stories but not all science fiction movies or stories have to be dark and gothic. Another definition of science fiction...\n2. The Science of make a World\n\n prove Count: 1768 Approx Pages: 7 Has Bibliography\n\nThe abundant expanses of post-apocalyptic Earths and undiscovered solar systems are all part of a deep and detailed pen system used to develop a realistic and act science fiction universe. ... By creating false representations of real world class systems, places and events, science fiction can develop a world which is a fictional metaphor of topical iss...\n3. contagious Cloning and a inquiry of Ethics\n\n ledger Count: 618 Approx Pages: 2 Has Bibliography\n\nWith this huge scientific leap, genetic cloning was no longer a clear science fiction fantasy, but a reality that would turn of events the world of medicine and science upside down. ...\n4. Reflective Essay - The Time Machine\n\n enounce Count: 1163 Approx Pages: 5 Has Bibliography\n\nThe first science fiction megatext archetype of The Time Machine is awareness. ... This blood of class can be found as a theme in the megatext genre of science fiction. ... Time buy the farm in the view of science fiction is primarily a subgenre focus of the term megatext. ... This of which, is macrocosm prompted directly from the Wesleyan Anthology of Sc...\n5. educate Science Exhibit\n\nWord Count: 684 Approx Pages: 3\n\nAs a part of festivity of the Del Pil ar Academys 65th innovation Anniversary, a science shew entitled as Science in Motion was held on the second day of the celebration. I enjoyed the whole exhibit because I saw or perceive some new feeble science gadgets, stuffs, equipments and ideas. ... It is so unforgettable and I learned many new scienc...If you want to get a full essay, rule it on our website:
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Chris Rock is the biggest reason to watch the Oscars 2016. The comedian will host the Academy Awards show for the second time. He hosted the Oscars way back in 2005 the first time.
Awards shows these days only are worthwhile watching if the host is funny. Ricky Gervais is the go to guy for the Golden Globes and he killed it. His jokes became memes on the web that got circulated all week after the show. Gervais just fired one insulting joke after the other at the Hollywood A-list.
The Academy Awards bet on Chris Rock to do the same. Well almost. I don't think Chris Rock can be as aggressive as Gervais at the Oscars. But maybe he does not care, which would be awesome.
A couple hours ago Chris Rock sent out a Tweet that already has the internet buzzing. "The #Oscars. The White BET Awards." This is hilarious and stings right into the annual discussion about most nominees being white.
The #Oscars. The White BET Awards. https://t.co/8qjLR0uysI
— Chris Rock (@chrisrock) January 15, 2016
The Oscars 2016 will air live on Sunday, Feb. 28 7pm ET on ABC. See also the complete list of the 2016 Oscar Nominations. The Revenant got the most nominations with 12, including Best Picture and best actor in leading role. Mad Max: Fury Road got 10 nominations. Star Wars got 5 Oscar noms, but only in second tier awards.
Originally posted in i4u News


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You can become a hero to those living with Multiple Sclerosis, by making a small $5 donation to Team Wipe Out MS. But no matter how much you can give every dollar helps to create a world free of Multiple Sclerosis.
Can we count on your donation so you can help keep research driving forward towards a goal of no one ever having to hear" you have MS your life is forever changed"?
Much of the money received stays here in Oklahoma and besides funding research provides support to both those with MS and their family. The average cost of treating MS is $69,000 per year.
There are 2 ways to make a donation either online or by making a phone call.
You can make your donation online by simply clicking on the orange "Donate To Wipe Out MS" button below. That will take you to the Team Wipe Out MS donation page on the National MS Society's website which is a secure site and all your information will be encrypted.
You can call toll free 1-855-372-1331 to make a donation. From a smartphone click on the green "Call To Wipe Out MS" button to click to call.


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text: An easy stop on the road awaits you at the Econo Lodge Inn and Suites Des Moines - Merle Hay Rd hotel in Des Moines, IA. Our hotel is near Drake University, Iowa State Fairgrounds, Wells Fargo Arena, Blank Park Zoo, Living History Farms and the Iowa Events Center. We provide all the amenities you need so you can stick to your budget and focus on the important reasons you travel, including free breakfast, free WiFi, guest laundry facilities and meeting space that can accommodate up to 150 event attendees. All of our guest rooms have a refrigerator, microwave and TV. Upper-tier suites have even more amenities, such as a hot tubs and balconies. Also, earn rewards including free nights and gift cards with our Choice Privileges Rewards program. This is a pet-friendly hotel. Pet policy, 10.00 per pet, per night. Maximum one pet per room.


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Elements Eight is a brand of rums made in St. Lucia by the makers of Admiral Rodney and Chairman's Reserve. The range includes gold, platinum and spiced rums, along with an expression infused with Criollo cacao beans.
Enjoy responsibly
Copyright © The Whisky Exchange 1999-2019. All Rights Reserved.
The Whisky Exchange is the registered trademark of Speciality Drinks Limited.
Registered in England and Wales (Company No. 4449145). Registered Office: Elixir House, Whitby Avenue, Park Royal, London NW10 7SF, UK.


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Alexandru Babes (Chair)
Department of Anatomy, Physiology and Biophysics, University of Bucharest, Romania
Gábor Pethő (Co-Chair)
Department of Pharmacology and Pharmacotherapy, University Medical School of Pecs Medical School, Hungary
10:30 – 10:54 Michael MJ Fischer
Center for Physiology and Pharmacology, Medical University of Vienna, Austria
"Tissue acidosis-induced pain"
10:54 – 11:18 Peter W. Reeh
Institute of Physiology and Experimental Pathophysiology, University of Erlangen, Germany
"Special voltage-gated sodium channels grant cold and heat resistance of nociceptive encoding – an overview"
11:18 – 11:42 Gábor Pethő (Co-Chair)
Department of Pharmacology and Pharmacotherapy, University Medical School of Pecs, Hungary
"Behavioural noxious heat threshold: molecular determinants, in vivo measurement and pathophysiological significance"
11:42 – 12:06 Alexandru Babes (Chair)
Department of Anatomy, Physiology and Biophysics, University of Bucharest, Romania
"TRPA1 and TRPV1, key players in light-induced pain"
12:06 – 12:30 Kata Bölcskei
Department of Pharmacology and Pharmacotherapy, University Medical School of Pecs, Hungary
"Novel, somatostatin-mediated peripheral antinociceptive mechanism mediated by stimulation of capsaicin-sensitive nociceptors"
Recent years have produced important progress in our understanding of cellular and molecular mechanisms of pain and temperature sensing in mammals. Pain can be evoked by activation of a dedicated population of primary afferent neurons, nociceptors. Nociceptive nerve endings express receptors and ion channels involved in sensory transduction, among which TRP (transient receptor potential) channels and Nav (voltage-gated sodium) channels play a key role. Our symposium will describe how some of these channels are involved in generating the sensory perceptions evoked by noxious heat, tissue acidosis and ultraviolet light. Moreover, these channels are known to undergo functional alterations upon activation of intracellular signalling pathways, and we shall describe novel sensitization mechanisms involved in pathological pain states. Our symposium will describe multidisciplinary research, from investigations of molecular determinants of ion channel function, to behavioural work in animal models and even human studies. Novel in vivo methods for the study of heat-evoked pain in animals will also be presented.
Prof. Peter Reeh will discuss recent finding concerning the ability of specific voltage-gated sodium channels to allow nociceptive nerve endings to function in a wide range of physiologically relevant temperatures. Prof. Michael Fischer will present exciting findings concerning the mechanisms of acid sensing as revealed in psychophysical experiments. Prof. Gábor Pethő will discuss behavioural work which addresses the contributions of several candidate heat sensors to establishing the noxious heat threshold. Finally, Prof. Babes will describe recent experiments which revealed an essential role for certain temperature-gated TRP channels in mediating the light-induced pain in several diseases associated with cutaneous photosensitivity and also in clinical treatments such as photodynamic therapy. The session will deliver an overall comprehensive picture of the status of pain sensing, from molecular and cellular studies, to animal behaviour and culminating with psychophysical experiments in human volunteers. In conclusion, our work will provide insights into novel therapeutic approaches to address pain in a variety of pathological pain states and human diseases.


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Hi there peeps and hope you are all OK today - it's the end of the week, woohoooooo :)
It's time to head on over to the Just Magnolia and hAnglar & sTanglar challenge where our hostess with the mostess this week is Julie and this week's theme is
Buttons & Bows
This week, we have two wonderful sponsors -
All That Scraps with any C.C. Designs stamp set of the winners choice …
and ….
The Ribbon Girl with this terrific prize.
Well I LOVE buttons and bows – you probably did notice that lol and this …
… is what I did.
I used my new Tilda from this latest stamp release – not sure what she is called, sorry peeps - and I coloured her with these Copics -
Skin – E000, E00, E11, E21, R00, R20
Hair – E43, E47, E50, E81
The rest – B00, B39, B93, B95, B97, C00, C1, C3, C4, C7, R02, R05, R17, R27, R59
The papers, which I am LOVING, are from this fab collection ….
It's the FQB Tour of London collection and it's perfect for everything that is happening here this summer.
I also used papers from the
Tour of London Too collection and both are of course from Nitwits.
The theme is Buttons & Bows and I did one of each lo!!!
The bow is made with 15mm Red No.15 Berisford Satin ribbon from The Ribbon Girl.
An array of gorgeous bloomage from Wild Orchid Crafts
I decorated the inside to match the front and I'll be putting this card on my ebay site tomorrow.
So that's it from me today.
I am a tad on the late side adding this cos it's been one of those bitty days. You know, when you don't actually get much done but you never seem to stop. And ladyship is in residence so I am guessing where we are off for tea!!! But I'll be back tomoz and I'll do my blast from the past as I didn't manage to get on here yesterday due to having to finish off a very big job which has been lurking for a week or so.
I'm going to Aintree in the afternoon to pick up some dies but it is a flying visit unfortunately – no time to stop and shop, cry cry. So I'll see you before I head off.
Till them. have a great Friday evening and huggiest of hugs to all xxx


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Sandra's got a great menu you can enjoy in the beauty of your own backyard. With Mascarpone & Grape Puff Pastry Bites, a light Herbed Rice Pilaf, Country Mustard Rubbed Pork Chops, O'Choco Cafe Cake and a Blushing Blossom cocktail.
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This week:
In the news, there's a new way to read SQL Server Documentation. In this week's feature, we'll continue the introduction to SQL Server Features and talk about SQL Server Replication. The web link shows you how Microsoft used Service Broker to put together MSDN and this week's tip is on SQL Server Services Accounts.
News this week:
Microsoft's MSDN Network now includes "tags" for the MSDN site, which allows you to apply your own meta-data to the content. Since SQL Server Books Online is hosted on the MSDN site, you can, in effect, now create your own "table of contents". Find out more here:
In a previous Podcast I started an overview of the major features you can find in SQL Server 2005. I'll cover each feature in more depth in future Podcasts, but we need a place to start the discussion for those features, so we'll cover the basics first.
This week we'll take a look at SQL Server Replication.
SQL Server Replication is a feature that, similar to SQL Server Clustering and Database Mirroring, copies data from one place to another. You could use this feature to make your systems more available, but with Replication you can copy a subset of data from one system to multiple other systems, on different platforms (such as Oracle and Microsoft Access), over longer distances, and on various schedules. So most of the time when you take advantage of this feature you'll use it to copy data, not to make your systems more available, although that it certainly an option.
Replication uses a "Publisher" and "Subscriber" methodology. What that means is that one system "Publishes" a set of data, and one or more systems "Subscribe", or ask for that data. This process can be pushed from the Publisher to the Subscribers, or the Subscribers can ask for the data, either on demand or on a schedule. Let's take a look at the entire process, and along the way I'll mention the systems and features that are involved in transferring the data. The process I'll describe is the logical flow – as the wizard guides you through the setup, you'll actually create certain features in a different order than I'll describe here. Don't let that confuse you – this is just an overview, so you still have a little study to do before you set up your replication.
To begin, you run a Wizard that prepares your installation and the databases that you want to replicate. In essence, this process creates the jobs, files and database objects needed to perform the data transfer. Three server types are involved: The Publisher, which contains the data to send, the Distributor which is responsible to hold and transfer the data, and the Subscriber, which receives the data. The hardware and software systems I'm describing can exist on one physical server, although normally these functions are broken out multiple systems.
At the lowest level of the process is the Article. An article is a table, a view or a stored procedure with Transact-SQL in it that represents the data you want to transfer. A wizard will guide you through the creation of your Articles after the system is prepared for replication.
The next level in replication is the Publication. This is the collection of Articles that you want to send to a Subscriber. Subscribers always ask for Publications, not for Articles, although you could set up a Publication with one Article in it.
The next level is the Subscription. The Subscription is set up to allow another SQL Server to receive the Publication. The Subscription can be "pushed", meaning that it is the responsibility of the Publishing system to move the data, or "pulled", meaning it is up to the Subscriber system to ask for the data. Push Subscriptions are most often used in constantly-connected systems, such as server to server, and Pull Subscriptions are often used when the systems are not always connected to each other, such as a salespersons laptop. Pull Subscriptions can be on-demand or at a scheduled time, and Push Subscriptions can work from a schedule, manually, or whenever data changes.
When you transfer data, you can move only the changes in the Publication, called Transactional Replication. You can also transfer the entire Publication, called Snapshot Replication. You can also transfer changes from the Publisher to the Subscriber, and changes from the Subscriber back to the Publisher, which is called Merge Replication.
So that you understand the power you have with this feature, you can Publish from one system to multiple Subscribers, or one Subscriber can get data from multiple Publishers, and many mixes in between.
Your Replication Topology, schedules and strategies are highly dependent on what your connection methods are and what you need to accomplish with it. You can read more at: http://tinyurl.com/6kwcnj.
Web Link:
You may have noticed that the content on the Microsoft Technical and Developer Network sites have changed. to aggregate the hundreds of thousands of documents they present, the team at Microsoft responsible for these sites used the Service Broker in SQL Server 2005. It's a fascinating study, and you can read it at http://tinyurl.com/6l38jn.
Tip of the Week:
SQL Server setup automatically configures the service account or accounts with the specific permissions required by SQL Server. When modifying or configuring the Windows services used by SQL Server 2005, you should grant only the permissions they require. For more information, see Setting Up Windows Service Accounts.


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On July 24, 2013, the Immigration Policy Center (IPC), the research and policy branch of the American Immigration Council (AIC), released fact sheets highlighting the contributions of immigrant entrepreneurs and innovators in ten states, namely Alabama, Arkansas, California, Florida, Indiana, Iowa, Michigan,North Carolina, South Carolina and Ohio. The organization's research shows that immigrant entrepreneurs are playing a key role in revitalizing state economies through innovation,… Continue Reading
Monthly Archives: July 2013
USCIS Moves Guangzhou Field OfficePosted in USCIS
The USCIS has moved the Guangzhou field office to the new U.S. Consulate General facility in the Zhujiang New Town area. Beginning today, all USCIS will be provided at this location. The exact address is as follows: U.S. Citizenship and Immigration Services U.S. Consulate General Entrance at Huaxia Road near Zhujiang New Town Metro Station… Continue Reading
White House Highlights the Need For Educated Immigrant Entrepreneurs and EmployeesPosted in Comprehensive Immigration Reform, EB-5 Program, Immigrant Visa
The Office of Science and Technology Policy ("OSTP") highlighted the need for immigration reform in a recently published blog post. Over 40 percent of Fortune 500 companies, including GE, Ford, Yahoo and Google, were founded by immigrants or children of immigrants. According to the OSTP, the recently passed bipartisan Senate bill would enact some of… Continue Reading
AILA Publishes Updated Summary of April 3, 2013, Joint SEC-USCIS Stakeholder ConferencePosted in EB-5 Program, Securities Law
AILA recently updated their executive summary of the USCIS EB-5 Engagement with the Securities and Exchange Commission ("SEC"). The two page document contains a summary of the highlights from the important April 3, 2013, teleconference with the USCIS and SEC. The SEC noted that the definition of a "security" is broad and most EB-5 investments… Continue Reading
A Quick Overview of EB-5 Trends and Events: What Recent History Tells Us and Predictions for the Years to ComePosted in EB-5 Program
Laura Reiff recently published an article on EB-5Investors.com entitled "A Quick Overview of EB-5 Trends and Events: What Recent History Tells Us and Predictions for the Years to Come". The article outlines the history of the EB-5 Immigrant Investor Program and the impact of recent developments in this area on future changes, priorities, and more…. Continue Reading
Greenberg Traurig Sponsors Premier EB-5 ConferencePosted in EB-5 Program, Speaking Engagement
Greenberg Traurig had the most representatives of any law firm at the EB5Investors.com 2013 Southern California conference. The EB-5 conference took place Monday, July 15, at the Balboa Bay Club & Resort in Newport Beach, California. The conference is the premier EB-5 stakeholder and dealmaker conference each year. In addition to the organizers, our own… Continue Reading
Kate Kalmykov Interviewed on Vietnamese Television StationPosted in EB-5 Program, Speaking Engagement
Attorney Kate Kalmykov was recently interviewed on Vietnamese-focused television station VIETFACE TV (VFTV). VFTV is a U.S.-based business that broadcasts 24 hours a day, including news, entertainment, talk shows, documentaries, reality programming and community programming. In the interview, Kalmykov discussed recent trends and developments of the EB-5 Immigrant Investor Program. Images from the interview are… Continue Reading
Nataliya Binshteyn Authors Article on New Rule to Implement JOBS ActPosted in EB-5 Program, Securities Law
Yesterday, the U.S. Securities and Exchange Commission (SEC) adopted a new rule to implement a Jumpstart Our Business Startups (JOBS) Act requirement that would eliminate the ban on general solicitation and general advertising for certain types of private securities offerings. GT Immigration attorney Nataliya Binshteyn published an article on EB5Investors.com outlining its significant impact on… Continue Reading
Congress and Immigration Reform – Overcoming Inertia and the Culture of "No"Posted in Comprehensive Immigration Reform
Much has been written about Comprehensive Immigration Reform (CIR) and the need to fix the serious mistakes of the 1986 Immigration Reform and Control Act. (For Greenberg Traurig's blog commentary about recent efforts to pass comprehensive reform, please click here.) The reality is that Congress is stuck in its own political quagmire. It is a… Continue Reading
EB-5 Step by Step Direct Investment ModelPosted in EB-5 Program, Immigrant Investor
Investment in the EB-5 Immigrant Investor Program is a pathway to United States citizenship that is increasing in popularity. This illustration outlines a ten step process for a direct investment, including necessary documentation, processing times and benchmarks. These steps – from your business plan to developing the I-829 template – are important to understand when… Continue Reading
SEC Liberalizes Restrictions on Advertisements of Most EB-5 ProjectsPosted in EB-5 Program, Securities Law
This morning, the Securities and Exchange Commission ("SEC") voted 4 to 1 to lift an 80-year-old ban on advertisements of private offerings. The Jumpstart Our Business Startups Act of 2012 ("JOBS Act") required the SEC to amend Rule 506 of Regulation D to permit general solicitation and advertising in private placements as long as all… Continue Reading
SEC to Take Up Long Delayed JOBS Act TomorrowPosted in EB-5 Program, Securities Law
Tomorrow, July 10th, the Securities and Exchange Commission will hold an Open Meeting at 10:00 a.m. at the SEC Headquarters Auditorium Room L-002 located at 100 F Street NE in Washington, D.C. to discuss the JOBS Act. Subject matters include: Consideration to adopt amendments to eliminate the prohibition against general solicitation and general advertising in… Continue Reading
Bureau of Economic Analysis Discontinues RIMS II ModelPosted in EB-5 Program, Immigrant Investor, Regional Center
Kate Kalmykov and James Cormie recently published an article on EB-5Investors.com outlining the announcement that the Bureau of Economic Analysis (BEA) will no longer produce the Regional Input-output Modeling System II (RIMS II) that many economists rely on when calculating Regional Center jobs. This update introduces new economic methodologies for EB-5 economists when estimating the… Continue Reading
Greenberg Traurig to Host EB-5 Finance Seminar in Denver on July 31stPosted in Immigrant Investor, Regional Center, Securities Law, Speaking Engagement
Greenberg Traurig, LLP will host the sixth event of the 2013 National EB-5 Finance Seminar Tour in Denver on Wednesday, July 31st. The seminar will expose participants to a unique alternative financing opportunity for projects that lend themselves to the EB-5 immigrant investor program. A panel of attorneys in Greenberg Traurig's Immigration & Compliance Practice… Continue Reading


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