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After a Two-week-break, Katelynn and Sara are back in school. Katelynn started her second semester as a Freshman. When she came home, she said, her interests are mixed and well balanced. There are two subjects she really loves, and two she is not so font with them. She usually loves Mathematics. But she doesn't like Algebra. I remember, first I wasn't a fan of Algebra either. But once I figured it out, it wasn't so hard anymore. But it took a bit to click in my head. Katelynn is going through the same struggles. She's excited for Science. She can't wait to talk about her collection of dinosaurs. Then there is another semester of Band in this school year. And English Language Arts is the other subject, she's raising her eyebrows. She was never a fan of ELA. 😀 But Katelynn has a lot of fun in High School. And that's also very important. Sara said, she had an amazing day in school, too.
Kevin celebrates his 44th Birthday, today. We were considering going out for his big day. But I could talk him into, me cooking a nice meal for him. Since the weather is in the 70s, I decided to cook some German Hamburger Patties, which are nicely seasoned. And as the side dish I made Potato-Cucumber Salad. Kevin agreed, my food tastes so much better. And it is much cheaper and healthier to eat at home. Our New Years Resolution is to reduce the days eating out and rather spend the time on cooking a decent meal at home. We are planning a trip to Seattle/Vancouver trip for this Summer. And in Spring 2020, we would like to go back to Walt Disney World. These trips cost a lot of money, and therefore I always need to find a way to save more $$$.


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|Return to nlist.3 CVS log
|Up to [cvs.NetBSD.org] / src / lib / libc / gen
|File: [cvs.NetBSD.org] / src / lib / libc / gen / nlist.3 (download)
Revision 1.11, Thu Aug 7 16:42:53 2003 UTC (16 years, 4 months ago) by agc
Move UCB-licensed code from 4-clause to 3-clause licence. Patches provided by Joel Baker in PR 22280, verified by myself.
.\" $NetBSD: nlist.3,v 1.11 2003/08/07 16:42:53 agc Exp $ .\" .\" Copyright (c) 1980, 1991, 1993 .\" The Regents of the University of California. All rights reserved. .\" .\" Redistribution and use in source and binary forms, with or without .\" modification, are permitted provided that the following conditions .\" are met: .\" 1. Redistributions of source code must retain the above copyright .\" notice, this list of conditions and the following disclaimer. .\" 2. Redistributions in binary form must reproduce the above copyright .\" notice, this list of conditions and the following disclaimer in the .\" documentation and/or other materials provided with the distribution. .\" 3. Neither the name of the University nor the names of its contributors .\" may be used to endorse or promote products derived from this software .\" without specific prior written permission. .\" .\" THIS SOFTWARE IS PROVIDED BY THE REGENTS AND CONTRIBUTORS ``AS IS'' AND .\" ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE .\" IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE .\" ARE DISCLAIMED. IN NO EVENT SHALL THE REGENTS OR CONTRIBUTORS BE LIABLE .\" FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL .\" DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS .\" OR SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) .\" HOWEVER CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT .\" LIABILITY, OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY .\" OUT OF THE USE OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF .\" SUCH DAMAGE. .\" .\" @(#)nlist.3 8.3 (Berkeley) 4/19/94 .\" .Dd April 19, 1994 .Dt NLIST 3 .Os .Sh NAME .Nm nlist .Nd retrieve symbol table name list from an executable file .Sh LIBRARY .Lb libc .Sh SYNOPSIS .In nlist.h .Ft int .Fn nlist "const char *filename" "struct nlist *nl" .Sh DESCRIPTION The .Fn nlist function retrieves name list entries from the symbol table of an executable file. (See .Xr a.out 5 . ) The argument .Fa \&nl is set to reference the beginning of the list. The list is preened of binary and invalid data; if an entry in the name list is valid, the .Fa n_type and .Fa n_value for the entry are copied into the list referenced by .Fa \&nl . No other data is copied. The last entry in the list is always .Dv NULL . .Sh RETURN VALUES The number of invalid entries is returned if successful; otherwise, if the file .Fa filename does not exist or is not executable, the returned value is \-1. .Sh SEE ALSO .Xr a.out 5 .Sh HISTORY A .Fn nlist function appeared in .At v6 .

subset: commoncrawl


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There are Windows servers out there that have been running happily for the last 10 years that are still working just fine. I wouldn't ever recommend formatting and reinstalling just because.
If you have a need for the newer version, or you have upgrade rights then by all means standardize on a single version, it'll make your life a lot easier only having a single version to manage on all your servers. But if you only have a few machines, and no upgrade rights, and there is nothing wrong with the machine, then I would leave the machine as is.
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President George W. Bush, standing before Congress one last time, urged Americans to stand confident against gnawing recession fears and be patient with the grinding war in Iraq.
Bush delivered his final State of the Union address before a hostile, Democratic-led Congress eager for the end of his term next January.
With his approval rating near its all-time low, the president lacked the political muscle to push bold ideas, and he did not try. The one possible exception was the economy. He urged lawmakers to approve urgently a $150 billion plan to stave off a recession through tax rebates -- negotiated with Democratic and Republican lawmakers -- for families and incentives for businesses to invest in new plants and equipment.
"As we meet tonight, our economy is undergoing a period of uncertainty," Bush said. "And at kitchen tables across our country there is concern about our economic future."
Since the 2003 U.S.-led invasion of Iraq, the war has been a main topic of Bush's annual addresses to Congress. He said the buildup of 30,000 U.S. troops and an increase in Iraqi forces "have achieved results few of us could have imagined just one year ago."
"Some may deny the surge is working," Bush said, "but among the terrorists there is no doubt. Al-Qaida is on the run in Iraq, and this enemy will be defeated."
Bush announced no troop withdrawals except for a start in the return of the 30,000 sent last year for his "surge" troop buildup. The White House said more withdrawals would depend on the advice of Gen. David Petraeus, the top U.S. commander in Iraq, and Ryan Crocker, U.S. ambassador to Baghdad. Congress, despite repeated attempts, has been unable to force troop withdrawals or deadlines for pullbacks, and Iraq has receded as an issue in Washington.
He also prodded Congress to extend a law that allows surveillance of suspected terrorists, renew his education law and approve free-trade pacts with Colombia, Panama and South Korea.
In the Democratic response to the president's address, however, Gov. Kathleen Sebelius of Kansas urged Bush to work with Congress and help the United States regain its global standing damaged by the war. "The last five years have cost us dearly -- in lives lost; in thousands of wounded warriors whose futures may never be the same; in challenges not met here at home because our resources were committed elsewhere," she said. "America's foreign policy has left us with fewer allies and more enemies."
The war in Iraq has claimed the lives of 3,940 members of the U.S. military and many times more Iraqis.
The annual State of the Union address normally ranks among the biggest events in the U.S. political calendar, delivered with pomp and ceremony to lawmakers from both chambers and to other powerful Washington officials attending the joint session. This year's speech has been overshadowed by the intense Democratic and Republican campaigns to succeed Bush, who is barred by the constitution from seeking a third term. Sen. John McCain, a leading contender for the Republican nomination to succeed Bush, did not even attend the session but stayed in Florida to campaign.
Aides had said Bush would not use Monday night's address as a summation of his time in office, but he did. He turned to the phrase "over the past seven years" when talking about some of the most-prized efforts of his administration: tax relief, participation in religious charities, his global freedom agenda and increased funding for veterans.
In past years, Bush has used the speech to announce major domestic programs or make foreign policy statements. In his 2002 speech, he declared Saddam Hussein's Iraq, Iran and North Korea to comprise an "axis of evil." In 2003, he set out the case for war against Iraq.
Since Democrats took control of Congress last year, Bush has struggled to win approval for initiatives. He has used his veto powers to block Democratic plans, however, including efforts to withdraw troops from Iraq and expand a children's health insurance program.
The rhetorical device that held the speech together was trust in people -- taxpayers, homeowners, medical researchers, doctors and patients, students, workers, energy entrepreneurs and others -- to drive their own success and that of the country. The unspoken message: government is not the answer.
On Iraq, Bush said U.S. adversaries have been hit hard, although "they are not yet defeated, and we can still expect tough fighting ahead."
There are 158,000 U.S. troops in Iraq, a number expected to drop to 135,000 by July. There are 28,000 in Afghanistan, the highest number of the war, which began there in October 2001. The Iraq war began in March 2003. Congress, despite repeated attempts, has been unable to force troop withdrawals or deadlines for pullbacks, and Iraq has receded as an issue in Washington.
Bush left the impression that he Is leaning more toward the status-quo reduction plan for troop levels in Iraq than toward decreasing them faster or more sharply. "In all we do, we must trust in the ability of free people to make wise decisions, and empower them to improve their lives and their futures," Bush said.


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I had a chance to catch up with Luca Manfé while he was in town for the Summer Fancy Foods Show. For those of you who haven't heard of this up-and-coming Celeb Chef & Bauli Brand Ambassador, he was a forerunner and winner of Masterchef Season 4. With a focus on Italian food, specifically his hometown in the Friuli Region, the Italian chef came out of the competition with his own cookbook, My Italian Kitchen, and the money to fund the pending opening of a restaurant that is years in the making. As a Bauli Brand Ambassador, Luca shows you how to use their authentic Italian brand holiday cakes like pandoro and panettone, and everyday items such as the Bauli croissants in creative ways, so you can really wow your guests. He also has his own catering company called "Dinner with Luca", for which he prepares meals for small groups. A temporarily native New Yorker, Luca, his wife and their child now call Houston their home.
Here's the scoop:
1. Whats the First Dish You Ever Cooked?
"My first dish was a Clams Risotto I made for my grandmother. It was a disaster. I put in rice, the whole package and no stock. But I was also about 10 years old."
2. Favorite Restaurant in NYC?
"I love Momofuku. [My favorite dishes are] Pork Buns and the smoked chicken wings. They make the best chicken wings in all of New York."
He also loves that Momo's menu is constantly changing. The idea of changing menus with the season is one he adopts in his own cooking.
3. What did you include in your book, My Italian Kitchen?
"The book is a lot of recipes from my mother and grandmother but with my own spin and changes. It's what I love to eat. And of course dishes from the show.
4. What type of cuisine and ambiance will your new restaurant have?
"I love rustic. It's going to be tapas, [and have] bricks on the walls, homey. Houston needs something like this. It is growing and in five years it will be a culinary destination in the United States.
5. What's your current cooking style?
"My cooking style changed after the show. I cooked every day, developed menus that change with the seasons. If you look at a dish from a year and a half ago (when he first one Masterchef), my cooking has completely changed. I make modern touches on classic Italian dishes… The best example would be lasagna. I used to make the classic lasagna, but now it would be more like a pork belly and mushroom lasagna… I am inspired by eating at restaurants."
6. What advice and tips would you give to a new chef who's just getting started?
"Use the internet", (MasterChef Manfé stressed how much he used the internet getting started in order to find recipes he could work with and eventually rework for his own point of view and style). "Understand and Respect Ingredients" (He believes everything has a special way it has to be cooked). "Practice! Its takes practice to cook something perfect every time. It is very hard to reach perfection."
I for one can't wait to visit Houston once that restaurant opens and will be following news of it every step of the way! In the meantime, we've teamed up with Luca and Bauli Brand to give one lucky reader a box of Bauli Mini Croissants.
To enter, subscribe to our site and leave a comment below with your name and email address.
Can't get enough of Luca? Check out his site: http://lucamanfe.com/
Instagram: https://instagram.com/lucamanfe/?hl=en
Facebook: https://www.facebook.com/LucaManfe
Twitter: https://twitter.com/lucamanfe
Main Photo by Fox
-Ashley Steinberg


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Children adulation to play; and toys accomplish breach fun and engaging. Experts in adolescent development say that toys advance absolute acquirements even as they entertain. Therefore, toys can be acquirements aids that accession assorted abilities in your child. Having said this, not allotment the adapted toys for your adolescent is detrimental. In fact, you accept to consistently accede age-appropriate toys and amateur if buying. How do you apperceive which toy is best for your child? The adviser beneath sheds added light.
Major toy categories accessible in the market
Auto-themed toys are some of the a lot of popular. Accouchement are able to play with all address of miniature cars including buses, cars, trucks and more. Accede this, every second, up to 8 Hot Auto are sold. This is a toy car brand.
There are simple and circuitous puzzles that clothing assorted ages. These toys are accepted to activate adroitness and accession analytical thinking. Rubik's Cube is one of the a lot of accepted puzzles which was created by a Hungarian toy maker. Today, puzzles accept gone to accession level.
These are some of the oldest toys. They are abundantly admired by girls because they are fabricated to resemble miniature babies. Plastic and bolt are the capital abstracts acclimated to actualize dolls. They are not alone acclimated by children; there are humans who aggregate them as keepsakes or to adorn their spaces. Some humans attach airy acceptation to dolls.
Construction sets
These are standalone pieces that can be abutting calm to anatomy a audible model. These models could be cars, houses and even spaceships. These toys are abundant for accouchement who like to be challenged. They are alternate and atom imagination. There are adults who aswell admire application these sets for fun.
Digital toys
These are some of the a lot of accepted toys today. This is because they are adapted with agenda technology. They are awful alternate befitting accouchement on their toes. They absorb basic elements in which accouchement can apprentice and admission different entertainment.
Toys that advance concrete activity
The a lot of acceptable toys in this class cover balls, jump ropes, hoops, tops, frisbee, bottom accoutrements and abounding others. These toys accomplish concrete action possible. Tricycles and bikes for accouchement will aswell advance activity; authoritative them abundant elements for play.
Ideal toys for assorted ages
0 to 12 months
A bairn babyish is just blessed celebratory their new surroundings. However, if they hit three months, they will be agog on affecting assorted items. Toys at this age will a lot of acceptable end up in the mouth. In this respect, you accept to advance top hygiene with toys. They adulation black and textured toys that assume amusing. In addition, they admire toys that aftermath assorted sounds like coiled and squeaking sounds. These are the best options for this age group.
- Rattles
- Crib mobiles that appear in ablaze colors
- Baby dolls or blimp animals that are creamy
- Floor gyms
- Fabric assurance that are baby
- Unbreakable mirrors
- Action boards
1 to 2 years
This is a absolute analytical age. Because of their bigger motor skills, your adolescent will ambition something added responsive. They can alpha to collaborate with toys such as the ones mentioned below;
- Bath-time toys like elastic ducks and boats
- Stacking rings
- Nesting cups and boxes
- Toys that can be pushed or pulled
- Agreeable toys such as drums, pianos and tambourines
- Cars such as black buses calm with mini abstracts of humans
2 to 3 years
This is a abundant age to acquaint bent toys. Your adolescent will ambition something that they can absolutely explore. They like phones and accessories that absolutely interact. Toys that appoint their accomplished boy are agitative and beneath is a list;
- Tricycles and added ride on toys
- Toy adaptable phones and play kitchen sets
- Flashy agreeable instruments
- Bigger dolls and blimp animals
- Puzzles and architecture toys
4 to 5 years
This is a almost complete age area there is allegation for added arduous toys. It is an ideal time to accept educational toys that activate their minds even more. The best options include;
- All address of assurance soccer, basketball
- Bicycles with training auto
- Added circuitous puzzles
- Action abstracts
- Barbie dolls
- Art and crafts kits
- Cyberbanking toys and touch-pads
- Costumes to dress up
- Board games
The allowances of affairs kid's toys online
A advanced arrangement of toys
Buying online will accord you admission to a advanced arrangement of toys for your children. You bounded concrete abundance may not even accept the accommodation to abundance the assorted options accessible online. This way, you can calmly get the ideal toys for your children. From dolls to blimp animals and agreeable instruments; you are baby for choice.
It is awful convenient
Buying toys online is absolutely convenient. With just a bang of a button, you will accept the adapted artefact delivered to you. For active parents and guardians who do not accept time, this is a abundant adjustment of killing two birds with a individual throw.
You admission cheaper toys
Buying online will save you money. This is because you can baddest the best prices that will clothing your budget. Also, you can analyze the prices from assorted online sellers to acreage on the best deal. Online, you can aswell buy anon from manufacturers; which will by itself save you money.
You get top superior toys
Because you can apprehend user reviews and artefact specifications, you will be in a position to accept toys that are of top quality. Knowing the assorted toy apparatus and abstracts acclimated therein will advice you accomplish a accommodation on adopted quality.
You can buy toys from overseas
If you like a assertive toy blazon from a specific country, affairs online will breach the concrete boundaries. This way, your adolescent can admire the a lot of acceptable toy sourced from around anywhere in the world.
Top tips for affairs children's toys online
Buy toys adapted for your child's age
This is the a lot of important affairs consideration. This is because you ambition to activate and absorb your adolescent in the a lot of able way. Toys that are not acceptable in agreement of age can even be alarming for your child. Therefore, yield time if analytic online and clarify the age you ambition to buy for.
Be added accurate on the toy size
Sometimes, it can be harder to actuate the absolute admeasurement of a toy online. It is acute to appeal this advice from your online agent if it is not provided. Buy sizes that are aboriginal and foremost safe. Secondly, buy sizes that you feel accord you amount for money. For example, if you are affairs a blimp animal, affirm that it is beyond than your fist; authoritative assumptions may advance to disappointment.
Consider the array needs
Many cyberbanking toys will be powered by batteries. In abounding instances, you will accept to buy these batteries separately. To this end, accede your account needs. Also, apperceive area to buy accordant batteries for the toys. Affairs batteries in aggregate is the best way to accumulate your adolescent happy. Otherwise, you will accept to argue with the altercation of affairs individual units.
Know the shipment details
From the acknowledgment behavior to the shipment fees and shipment time, get abreast accordingly. Your online banker should allegation a reasonable fee for shipping. If the toy is torn or is not what you were searching for, you should acknowledgment it aural a abbreviate window. The shipment continuance will accord you an abstraction as to if you will accept the package.
Read online user reviews
See what others accept to say about the toy. Were abounding users captivated or was the toy a huge disappointment? Evade accepted pitfalls by accepting aboriginal duke advice from absolute customers. This is one of the claim of affairs toys online; you get acknowledgment that is eye-opening.
Did you apperceive this about toys?
- Toys are some of the better consign items by China. In fact, they accomplish up to 70% of all toys in the world.
- The better toy bazaar globally is America at 41% followed by Europe at 29%, Asia and Oceania represent 30% of the absolute toy bazaar while Africa is far abaft with a allotment of alone 1%.
- Mr. Potato Head is the aboriginal anytime toy to be advertised on television and the oldest toy in history is a stick.
- Did you apperceive that Lego was not the aboriginal name? The aboriginal and aboriginal name was Automatic Binding Bricks.
- In 2012, a toy fabricated its way to the International Space Station, address of an American astronaut. This toy was the Red Bird of Angry Birds.
– electronic toys


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Vero Beach, Florida
January 3, 2007
We're finally ready to leave Vero Beach and will be heading out later today. The last couple of nights the wind has died down completely and we've been swimming in little bugs called "no-see-ums." They seem to have a special affinity for Kristen's blood, and she is covered with dozens of bugbites from head to toe.
Yesterday was spent running errands, getting groceries, etc. We'll head down towards Ft. Piece today and then go to Palm Beach tomorrow where we'll hang out and wait for weather and complete some projects on the boat. Hopefully we'll be able to cross over to the Bahamas from Palm Beach in the next week or two.
Blogger is having issues today, so no pictures.


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A new study has attempted to determine whether Wyeth Pharmaceuticals' controversial antidepressant Effexor (generic: venlafaxine) has the potential to cause birth defects in babies born to mothers who take the drug during their first trimester of pregnancy. The research involved data from the National Birth Defects Prevention Study (NBDPS), and found 'statistically significant associations' between Effexor exposure and a number of serious congenital abnormalities. The results of the study suggest that, when taken by expecting mothers early on in the course of their pregnancies, Effexor can cause severe birth defects.
What's the problem?
The study, which was conducted by a research team led by Kara N. D. Polen, involved mothers with pregnancies affected by one of 30 selected birth defects, and a control group of babies born without congenital abnormalities with estimated dates of delivery between 1997 and 2007. Exposure was defined as any maternal use of Effexor from one month preconception through the third month of pregnancy. The results of the study found that, among the 27,045 NBDPS participants, 0.17% (14/8002) of control mothers and 0.40% (77/19,043) of case mothers reported any use of Effexor during the designated exposure periods.
The research identified 'statistically significant associations' between Effexor exposure and the following congenital birth defects:
Manufactured and marketed by Wyeth Pharmaceuticals, Effexor is an antidepressant that belongs to a controversial class of medications known as serotonin-norepinephrine reuptake inhibitors (SNRIs). Drugs from this class are typically prescribed to treat depression and generalized anxiety disorders. Studies have estimated that approximately 20% of pregnant women suffer from depression, and nearly 10% suffer from anxiety. Taking these figures into consideration, it is easy to understand why millions of pregnant women around the country are prescribed Effexor and other similar antidepressants each and every year.
Yet despite its widespread popularity and considerable effectiveness as an antidepressant medication, Effexor has once again proven to be dangerous to unborn babies when taken by expecting mothers early on in the course of their pregnancies. Polen's research team concluded that there are indeed strong correlations between periconceptional use of Effexor and the above-listed birth defects. However, the authors caution that the study's sample size was quite small, and that additional research needs to be conducted in the future to confirm the results.


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Team is a contemporary Slovak rock music band. They are most famous for a single from their third album which was called "Držím ti miesto", which was included in the soundtrack of the 2005 American film Hostel.
Germany B (or Germany A2) is a secondary team for the national football team of Germany, used to try out and develop players for potential inclusion in the first team. The team - which has not been active since 2006 - can play against other nations' B-teams, or against full national teams, but its matches are not considered full internationals. In its last incarnation the team was named Team 2006, as a development team for the 2006 FIFA World Cup, which was to be hosted in Germany.
In 2000, when Germany was selected to host the World Cup, the national team was in decline - the squad was ageing, with little in the way of emerging talent. After the team was knocked out in the first round of Euro 2000, the German Football Association decided to form 'Team 2006' - a development team for young players, with the hope of producing a squad that could perform at the 2006 World Cup. The team played ten fixtures between 2002 and 2005, with four wins, four draws and two defeats.
The United States Naval Special Warfare Development Group (NSWDG), or DEVGRU, is a U.S. Navy component of Joint Special Operations Command. It is often referred to as SEAL Team Six, the name of its predecessor which was officially disbanded in 1987. DEVGRU is administratively supported by Naval Special Warfare Command and operationally commanded by the Joint Special Operations Command. Most information concerning DEVGRU is classified and details of its activities are not usually commented on by either the White House or the Department of Defense. Despite the official name changes, "SEAL Team Six" remains the unit's widely recognized moniker. It is sometimes referred to in the U.S. media as a Special Mission Unit.
DEVGRU and its Army counterpart, Delta Force, are the United States military's primary counter-terrorism units. Although DEVGRU was created as a maritime counter-terrorism unit, it has become a multi-functional special operations unit with several roles that include high-risk personnel/hostage extractions and other specialized missions.
Reality is the state of things as they actually exist, rather than as they may appear or might be imagined. In a wider definition, reality includes everything that is and has been, whether or not it is observable or comprehensible. A still broader definition includes everything that has existed, exists, or will exist.
Philosophers, mathematicians, and other ancient and modern thinkers, such as Aristotle, Plato, Frege, Wittgenstein, and Russell, have made a distinction between thought corresponding to reality, coherent abstractions (thoughts of things that are imaginable but not real), and that which cannot even be rationally thought. By contrast existence is often restricted solely to that which has physical existence or has a direct basis in it in the way that thoughts do in the brain.
Reality is often contrasted with what is imaginary, delusional, (only) in the mind, dreams, what is false, what is fictional, or what is abstract. At the same time, what is abstract plays a role both in everyday life and in academic research. For instance, causality, virtue, life and distributive justice are abstract concepts that can be difficult to define, but they are only rarely equated with pure delusions. Both the existence and reality of abstractions are in dispute: one extreme position regards them as mere words; another position regards them as higher truths than less abstract concepts. This disagreement is the basis of the philosophical problem of universals.
Reality (French: Réalité) is a 2014 French-Belgian comedy-drama film written and directed by Quentin Dupieux. The film premiered in the Horizons section at the 71st Venice International Film Festival on 28 August 2014.
"Reality" is a song performed by English singer Richard Sanderson. It was released in 1980 as part of the soundtrack to the popular 1980 French film La Boum, which starred French actress Sophie Marceau (who later starred in popular films such as Academy Award-winning Braveheart and James Bond franchise The World Is Not Enough). It was also served as the theme song to the 2011 Korean film Sunny.
Musically, "Reality" is a ballad, sometimes called an adult-contemporary song, and consists of synthesizers and guitar riffs which cause it to be classified under the soft-rock genre. It was composed by Vladimir Cosma, written by Jeff Jordan and produced by Pierre Richard Muller. Between 1980 and 1982, then in 1987 after its re-release, it became a major hit in Europe and Asia, topping the charts in fifteen countries including Germany, France, Italy, Austria, Finland and Switzerland and selling more than eight million copies worldwide, making it one of the best-selling singles of all time. The song led Richard Sanderson to stardom, giving him more hits with Cosma such as "Your Eyes", "She's a Lady", and "Sun".
Team is a contemporary Slovak rock music band. They are most famous for a single from their third album which was called "Držím ti miesto", which was included in the soundtrack of the 2005 American film Hostel.
Metro UK | 12 Dec 2019
WorldNews.com | 13 Dec 2019
The Independent | 13 Dec 2019
The Times of India | 13 Dec 2019
Russia Today | 13 Dec 2019
BE Soccer | 13 Dec 2019


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Prostate Cancer Channel
Topics & Medications
Related Channels
What If I Take an Overdose?It is not entirely clear what to expect from an overdose with this medicine. Seek immediate medical attention if you or someone else happens to take too much Emcyt.
(Click Emcyt Overdose for more information.)
How Should This Medicine Be Stored?Store Emcyt in the refrigerator. Keep this and all other medications out of the reach of children.
What Should I Do If I Miss a Dose of Emcyt?If you miss a dose of Emcyt, simply take it as soon as you remember, unless it is almost time for your next dose. In this case, skip the missed dose and continue with your regular schedule. Do not take a double dose.
Available StrengthsEmcyt capsules come in one strength: Emcyt 140 mg.
Can I Buy Generic Emcyt?This medication is not available in generic form (see Generic Emcyt).
Emcyt Chemotherapy Information
List of references (click here)
Emcyt [package insert]. New York, NY: Pharmacia & Upjohn Company;2007 June.
Estramustine phosphate. Drug Facts and Comparisons. Drug Facts and Comparisons 4.0 [online]. 2012. Available from Wolters Kluwer Health, Inc. Accessed August 20, 2012.
Food and Drug Administration, Center for Drug Evaluation and Research. Electronic orange book: approved drug products with therapeutic equivalence evaluations. FDA Web site. Available at: http://www.fda.gov/cder/ob/. Accessed August 20, 2012.
Briggs GG, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 8th ed. Philadelphia (PA): Lippincott Williams & Wilkins;2008.
Written by/reviewed by: Susan Lakey, PharmD, MPH, BCPP
Last reviewed by: Kristi Monson, PharmD


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After their stunning comeback in the North London derby yesterday, all the talk this morning is about Harry Redknapp's men. The White Hart Lane club have certainly showed their title credentials with that win, but could they really mount a serious challenge for the Premier League this season?
Harry Redknapp certainly feels they can. Talking after the win at the Emirates Stadium, the former Portsmouth manager said: "We can beat anybody. This has put us right back in the race again. It's wide open. We're not writing ourselves off, you've got to aim for the top. If my players believe in themselves as much as I do, we can achieve anything."
Redknapp is quite right to believe that his side do have a very good chance of winning their first league title since 1961, because this season every side has been inconsistent. You have to feel that anyone from five sides could win the Premier League this season.
But Spurs, Manchester City, Chelsea and Arsenal have all shown that they are currently lacking any real momentum and while Manchester United are yet to lose a game this term, they haven't reached anywhere near their top form.
This means the league is very much up for grabs, and if Tottenham can make use of the depth in their squad it might just be their year. Redknapp has an amazing wealth of talent at his disposal and that could really be something which could bring his side success this season.
Chelsea have shown in recent weeks what happens when they are without their top players, but if there was to be a similar injury crisis at White Hart Lane, you have to feel that they would be able to cope better.
In an era where three games a week is the norm, a big squad is so advantageous now. Manchester City and Tottenham have the two strongest squads in the league, and if other sides suffer with injuries you have to feel that either could be an excellent position to win the league.
Luck will have to go their way, but the simple answer is; Yes, Tottenham could win the Premier League this season. Personally I don't think they will but stranger things have definitely happened in football.
What do you think? Could the Premier League Trophy find a new home at White Hart Lane this season?


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Welcome to LAMP where we provide a nurturing academic environment for teen parents and their children. Please be sure to browse our website for important information including calendars, news, and resources.
If you would like more information about Early Childhood Learning Services or the nursery program for LAMP please contact: firstname.lastname@example.com
Welcome to LAMP! Pregnant and parenting students attending LAMP have access to this voluntary, instructional program that are comparable to other high schools including classroom and online instruction, on-the-job training, and dual enrollment. The program does not limit students' academic career, vocational or extra-curricular options. LAMP partners with the Early Childhood Center where LAMP infant and toddlers attend and are eligible to apply for Early Head Start, Child Care Partnership and Head Start services. We are here to help our students every step of the way, encouraging them to grow, get their educations, advocate for their children, become strong and encouraging parents, and become productive members of their society. If you have any questions, or would like further information about our program, please feel free to call our office at 239-332-2526.
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The FLEXTURBINE project will have major impacts with regard to the EU policy objectives for electricity generation, defined in the energy roadmaps 2030 and 2050:
These three policy objectives have to be pursued simultaneously, are mutually interdependent and have to be balanced against each other.
Increased efficiency leads to reduced emissions and lower cost of electricity. Faster ramping and increased cycling enable fossil fuel plants to balance the fluctuating renewable energy from solar and wind. This will help ensure energy security and supply via a stable grid without the need for unnecessary over capacity or excessive grid development. Increased flexible fossil energy supply allows the portion of renewable to rise to significantly higher levels, which will help the EU achieve the low carbon targets. The economics of energy supply should be better if fossil power generation can be extended instead of having to create new capabilities to fill the renewable fluctuations such as storage.
FLEXTURBINE significantly contributes to the social target of Low-Carbon-Energy at different levels:


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StrengthsFinder 2.0
Frequently Bought Together
Discover your strengths and learn how to use your greatest natural talents to get the most out of your life.
Chances are, you don't. All too often, our natural talents go untapped. From the cradle to the cubicle, we devote more time to fixing our shortcomings than to developing our strengths.
To help people uncover their talents, Gallup introduced the first version of its online assessment, StrengthsFinder, in the 2001 management book Now, Discover Your Strengths. The book spent more than five years on the bestseller lists and ignited a global conversation, while the assessment helped millions discover their top five talents.
Now, Gallup unveils the new and improved version of its popular assessment, language of 34 themes and much more. While you can read this book in one sitting, you'll use it as a reference for decades.
Loaded with hundreds of strategies for applying your strengths, this book will change the way you look at yourself — and the world around you — forever.
Product Details
|Gallup Press
|Publication date:
|Sales rank:
|Product dimensions:
|4.90(w) x 7.10(h) x 0.90(d)
About the Author
Tom Rath is a leading business thinker and one of the bestselling authors of the last decade. His books include the #1 New York Times bestseller How Full Is Your Bucket?, Strengths Based Leadership and Wellbeing: The Five Essential Elements. He earned degrees from the University of Michigan and the University of Pennsylvania. Tom and his family live in Washington, D.C.
Read an Excerpt
Chances are, you don't. All too often, our natural talents go untapped. From the cradle to the cubicle, we devote more time to fixing our shortcomings than to developing our strengths.
To help people uncover their talents, Gallup introduced the first version of its online assessment, StrengthsFinder, in the 2001 management book Now, Discover Your Strengths. The book spent more than five years on the bestseller lists and ignited a global conversation, while the assessment helped millions discover their top five talents.
Now, Gallup unveils the new and improved version of its popular assessment, language of 34 themes and much more. While you can read this book in one sitting, you'll use it as a reference for decades.
Loaded with hundreds of strategies for applying your strengths, this book will change the way you look at yourself — and the world around you — forever.
Table of Contents
StrengthsFinder: The Next Generation
PART I: Finding Your Strengths An Introduction
PART II: Applying Your Strengths
The 34 Themes and Ideas for Action
VFAQ (VERY Frequently Asked Question)
Customer Reviews
Average Review
Most Helpful Customer Reviews
Strengths Finder 2.0 is the follow up to Gallup's Now, Discover Your Strengths. The book includes a revamped version of the StrengthsFinder test that shows you not just what your top five strengths are, but also how you rank in the rest of the 34 strengths from Clifton's model. The new book is light on content (very light) but the test is a substantial improvement. Here's how the book is set up: StrengthsFinder: The Next Generation (A short introduction explaining the need for the enhanced edition of the test based upon new thinking and research in strengths psychology) I: Finding Your Strengths (A 30-page overview of strengths psychology and how the Gallup system works) II: Applying Your Strengths (150 pages outlining each of the 34 themes including what people with that strength look like, how to manage them, and ideas for action if you have that strength). The StrengthsFinder (If you haven't taken it before, the code to take the test is provided in a packet inside the book. You actually have to buy the book to take the test) Emotional Intelligence 2.0 is another book I really enjoyed that follows the SF 2.0 format. Obviously, that test measures emotional intelligence (EQ), but Emotional Intelligence 2.0 has a unique format where the test tells you which of the book's 66 strategies will increase your EQ the most.
A couple of years ago I took the Clifton StrengthsFinder assessment in my workplace. I found the output of the assessment to be very valuable, as one might expect. I especially found the sections on applying strengths in academics, relationships, study techniques and career quite beneficial. Recently, to help my son 'soar with his strengths', I purchased version 2.0. While the assessment outputs the same 34 themes, it has, as my wife put it, decended into feel-good, vague, pyscho-babble. Maybe it's just the way the report is laid out now, but the 2.0 version doesn't seem to be as concise and targeted as version 1.0. Maybe newer isn't always better.
What a disappointment this book was. The topic is wonderful; the idea of finding out what you are strong at is an eye opening journey. I recommend "Now, Discover Your Strengths" by Buckingham to find out about yourself. This book promises to build on Buckingham's book, but it fails miserably: it's a watered-down version; for example, Buckingham's book covers in great detail how we are formed by our environment. This merely glosses over the topic; in fact, I felt like most of the book was copied and pasted: it's like a "Cliff Notes" version of "Now, Discover Your Strengths." The online test is almost the same for both books, e.g., they are both from Gallup. So, boooo Tom Rath. I read this book in one hour (after reading the other), and I felt cheated.
I loved the first book "Now Discover Your Strengths" because I felt the premise was important and the exploration was innovative. When I took the online assessment, I was surprised by the results. They didn't seem to fit my strengths. I bought this book, as I was curious to read the results of the feedback from the first book and how it was presented. I found little new. The assessment however, was much improved, and this time, I related to two of the top five strengths. I recommend this book because of the improvemed assessment. I definitely recommend the "Optimal thinking online assessment" to learn about your dominant level of thinking and patterns of thinking and how to optimize communication with others. Do both!
I found this book and assessment so accurate and helpful. You have to understand the book is good for only one assessment and when you take it - answer from your heart - not what you think is best - that will give you the most accurate results. My husband took it as well and we shared our results - helped me to understand why he does some things that I don't get! Our adult kids took as well and it was a great insite into who they are as individuals. So don't take it if you are determined to have it come out a certain way or you don't want to open with yourself.
StrengthsFinder 2.0 is another useful tool. However, if you are in any position of leadership it would be better to buy "Strengths Based Leadership" because you'll get the same info PLUS some additional info that is worthwhile. On the negative. I wish these guys would offer the ability to take the assessment without having to buy the book every time you want to take it. I mean come on - it is ridiculous to have to buy two books so that both my husband and I can get a StrengthsFinder assessment.
I had purchased "Now, Discover Your Strengths," by Buckingham & Clifton earlier this summer and found it helpful in pinpointing my top five strengths. Like many other individuals, I discovered strengths that were so natural that I had often overlooked them in my career. It was also a wonderful re-enforcement tool in what I had done in my career. A couple of weeks ago, I purchased "Strenths Finder 2.0," by Tom Rath and discovered a new strength that was listed as #2, which had not been on my original list. This particular strength seemed more natural than one that was on my original list of strengths (Buckingham & Clifton). This book has become a good source and reference book in discovering and understanding my strenghts. I would highly recommend this book to anyone who is wondering what to do next in their career or out of a job and looking for some guidance moving forward with other insights or possibilities for career development.
I feel scammed: You can only take the online assessment which determines your 'Top Five' one time. This is not clearly spelled out in the book or the website. If you want to take it again, you have to buy another book and get a second 'Access Code'.The book itself is just a short intro followed by a list of the '34 Themes' with little blurbs of explanation - not useful unless you take the assessment which I took without giving it much thought, foolishly thinking I'd just take it again later. My results are not at all accurate (spouse of 22 years agrees). I do think that if you take the test and get valid results, the supporting materials and suggestions to maximize your strengths are quite impressive but I'm really frustrated by the way the authors have chosen to limit access to the test.
One of the most helpful things about StrengthFinder 2.0 is that it helped me to know myself better. I have always suspected my strengths, but seeing it on paper, helped me to be able to focus in a whole new way. I find myself daily thinking, "That is an evidence of my strength." It has been so helpful to me that I bought seven other copies for people that are close to me so that they can learn about themselves as well. It is a great resource for teams that are seeking to work together at a higher level. We used it for a staff retreat, making a game of guessing what each person's strengths were. It has helped us greatly in knowing how to work together. I highly recommend this book.
No one is immune to the road of self-discovery. This is not the road less traveled. Strength Finders 2.0 is a great tool to help manage to process of self-awareness. This book is a great resource to help you not only to identify your strengths, but to also give you practical explanations and applications. Strength Finders 2.0 also has a companion website where you will answer questions used to compile a personal profile of your most dominant assets. Both the book and the website give an in depth perspective, so that you are not left with just some vague appeasing titles. More importantly, this book is not about becoming a new person, it is about revealing who you already are and acknowledging things undiscovered and untapped.
I loved this book. It is unreal how accurate the assessment is. We are using it in my place of employment as a training tool and doing a workshop on it. I can't wait to see what my co-workers strengths are and how they compare or relate to mine. I had my husband take the test too and his strengths were dead on. It helped me to stop and reflect on the things I know about him that are sometimes a bother to me, but they are part of who he is, and they are what makes him great. A nice reminder of things that made me fall in love with him in the first place. Thanks for focusing on what makes us great instead of what makes us weak. As humans that is the course we usually take... focusing on weaknesses. This book is a refreshing change.
I purchased this book for my work and I must say, this is one of the most relevant and economic books! We usually focus on our weakness as one of the objectives to work on throughout the year but this book focuses on the strength, which is rather refreshing. You will also be given an access code to actually find your strengths, followed by action plans which gives you a good idea on how to reinforce those strengths. It is really an easy reading book. You'll read the first 30 pages or so (big font) and the rest is the descriptions on each strengths. Happy reading~
Loved it! Great book. My work gave me a training session on my strengths. . . As soon as I got home from work, I went to Barnes and Noble to buy one for my husband so I could see what his strengths were.This was actually me 2nd time to take the test. The first time was four years ago. The book is accurate, my strengths stayed the same!
I would recommend this book for anyone that is searching for a true objective view of what makes them tick and shine. After I took the test I realized that I took all of my strengths for granted. I really never considered them as strengths. I now know what I like and why I like something. It is not that this was new information to me, but now I look at my work and interactions with other people and know what I can do and cannot do to be more effective. I leave the rest of the actions to those that are good at them. I highly recommend getting the people you are close with at work and home this book. I have and it has been helpful and fun.
I found this book very informative, and the survey helped me learn a little more about myself. Since it focuses on strengths, I used it to compliment other personality profiles that I've taken in the past.
Thie book is really a great read for managers who want to know how to make their employees engaged and satisfied with their jobs. I would reccomend other reads to supplement the information in the book. Essentially the premise is based on positive psychology, and says that if we focus on what we are good at rather than focusing on the negatives, we can truly become great. However, I have seen managers go the other way with this book and use it to focus on the strengths someone does not possess rather than those they do.
Strengths Finder 2.0 is the follow up to Gallups Now, Discover Your Strengths. The book includes a revamped version of the test that shows you not just what your top five strengths are, but also how you rank in the rest of the 34 strengths from Clifton's model. The new book is light on content (very light) but the test is a substantial improvement. If you haven't taken it before, the code to take the test is provided in a packet inside the book (you actually have to buy the book to take the test). I've enjoyed two other books recently that include a code to let you take an online test. One is The Emotional Intelligence Quick Book (has fascinating stories and research as well) and the other is The Personality Code (kind of like the strengths but also focused on overcoming your weaknesses and avoiding clashes with your personality's anti-type).
As a professional Human Resource developer, I have designed and implemented curriculum for the development of leaders, supervisors, managers, and executives. All of these supervisors are involved in professional endeavors. They are aware they have talents. It is a variety of situations that challenge them in their use of their talents. Usually, these talented people also know, no one working for them will honestly comment on their perceptions of those talents. If they do comment it is in a heat of anger or a splash of praise, not usually in an honest evaluation for formative purposes. In fact, most supervisors do not solicit nor value subordinate evaluations. Therein lies the value of 'Strength Finders.' It allows the supervisor / executive to honestly do a self evaluation by applying an objective criterion. It is useful, used, and helpful to motivate self - managed change. Thus, using the 'Strength Finder' a supervisor can honestly participate in their own honest evaluation. It's value is given the weight of the participant not some external evaluator. It is an evaluation interpreted by the participant, too. It truly stands on what the participant puts into the evaluation process for self awareness and development.
After the test you'll be still struggling to find your strengths. The test is useless, I can't recommend it to anyone just waste of your time and money :(
I must admit to having borrowed the book from the library and did not take the test. I'm also glad I didn't spend the 30$. There are pros and cons to buying:Pros: you are thinking about changing careers; you don't enjoy your current job; you're starting out in your career; in other words, you need some guidance on what might be a best fit. This book will help you concentrate on what you do best to succeed - and to find people with other strengths to fill the gap for the ones you don't have.Cons: you know yourself well; have already tried various personality tools; are successful in your career. This tool will not significantly enhance what you already know and will not bring any real insight (which was my case).A generally well-thought out book with a variety of skills to consider (although some I found repetitive). A sound marketing strategy, but I found expensive for what it offered.
I have taken the Meyers Briggs test many times and feel that this evaluation provided more insight into my specific drivers and values than the MB test ever did. I plan on preparing a strategy to capitalize on my strengths and will probably give this book as a gift to quite a few people this holiday!
I gave this book one star only because I like it's premise - stop spending so much time focusing on your weaknesses and embrace and build your strengths. Personally, I believe this is an important point for both adults and children.Beyond that point, this book is typical self-help drivel. It has essentially one chapter that you can read in 30 minutes or less. What you really buy the book for is the sealed code in the back pocket which allows you to take an online test which "determines your strengths". You go through umpteen million multiple choice questions and it spits out your "Top 5 Themes" and an "Action-Planning Guide". I say horseshit.I hate to sound so negative about it but here are my two issues:#1 - my five themes, I could have guessed. They just gave them fancy made-up names (Relator, Intellection, Strategic, Input, Learner). WTF?#2 - Their "Theme Descriptions" do nothing more than regurgitate words from the questions you just took. I mean really, how hard is it to write a description of a "Learner"?#3 - Their "Ideas for Action" - again, garbage. Two examples straight from my "Intellection Theme": "Consider beginning or continuing your studies in philosophy, literature, or psychology. Youwill always enjoy subjects that stimulate your thinking." and "You are at your best when you have the time to follow an intellectual trail and see where itleads."OK, Captain F'n Obvious, if I tested as having an Intellection Theme, don't you think I'm doing these things already?I was sorely disappointed in this book although when I picked it up, I did get a faint whiff of suck. It's such a good premise too...
My boss bought this book for me. We all took the 'test'. It was amazing how accurate the results felt. Did I gain new insight into myself? Not really. Did it sound more accurate then say astrology? Definitely.
Outstanding. Small but powerful, especially as a support for the online assessment. Works great with high school juniors and up in gaining insights for directions in college. Buy it!
If you purchase this book, it's mainly for the code in the back of the book, which you can use to take an online test from the author. It's definitely worth the money, if you care about finding your strengths.I'd go so far as to say it's life changing.


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Natural light can create the best pics and when it comes to trying to get a great pic of our pets we all know that a flash on the camera often gives our dogs and cats lazer eyes. It's beyond red-eye… you know, that glowing weird green color that their eyes get because of the flash or we end up with a bunch of pics with their eyes closed because the flash made them blink.
Natural light means we can get a pic of them with all the contrast between light and dark on their fur that can make them look regal, handsome, and great! Here are 4 tips to get the best lighting for our pet pics.
1: Pick the time of day to shoot based on the lighting. Using natural light means knowing when the best time of day is to have your photo shoot. Morning and evening can bring you softer lighting with touches of cool or warm tones. Midday can be bad because of the harsh shadows. If you're shooting indoors, the brightest part of the day may work because of the way the light diffuses through your windows and into your home. Try to coax your pet close the light source and snap away!
2: No flash! Unless you want your pet to look possessed and alien-like. You'll get better colors without a flash and avoid your pet walking or running away in disgust.
3: If you're looking for a way to reflect the light around your cat or dog during the shoot, the best and lowest cost reflectors to use are the ones on your car windshield. They are cheaper than the professional photographer ones and work just as well. Just prop them or have a friend hold them for you to add light to a dark or shadowed area.
4: Cloudy days can be great outdoor photo shoot days for your pet! The lighting can be amazing, creating even lighting all over and allow for close-ups with lots of detail.
Good luck! Some cats and dogs always seem to fidget and get easily distracted. Make sure you have a treat or something to hold their attention.


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The Fix-ins.
On the LBGE @ 400* until soft.
One hour
Now for the rest
Served with Kale, Date, Almon salad. both were wonderful.
This recipe was given to me by Morro Bay Rich.
Thank You so very much Rich!
Thanks for look-in!
For people interested in grilling, smoking, and baking on The Big Green Egg
This site is a member of
The Smoke Ring


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Story Loris Baby Clothes
Shop Story Loris Baby Clothes
Buy Story Loris Kids Clothes
Family business Story Loris was founded back in 1949 by Loris Stori. Ever since then, "Quality without compromise" has always been Story Loris 'philosophy and strategy. At its beginnings, the company manufactured socks for men only. Then in the early '50s it started manufacturing baby/children's hosiery. Ladies' hosiery production quickly followed. Beachwear, underwear and sleepwear collections for children from 0 to 16 years have recently been added to the product range. Baby/children's hosiery and accessories include socks, tights, leggings, booties, baby shoes, hats, gloves, scarves, hairbands; baby/children's underwear and sleepwear: rompers, bodysuits, tank tops, t-shirts, knickers, boxer briefs, pyjamas, nightgowns, dressing gowns; baby/children's beachwear: swimsuits, bikinis, swim-pants, shorts, beach dresses, maxi-shirts, etc. All baby clothes collections include a range of basic styles which are available for immediate delivery all year long. All hosiery is crafted in their own factory-workshop with the most valuable raw materials: cashmere, silk, Merino wool, Egyptian cotton, PIMA cotton and more. Strength point for products lasting and appeal is the use of only double twisted yarns. Strictly natural raw materials guarantee transpiration, hygiene and comfort. Choosing Story Loris means choosing classic and distinguished garments, all handmade entirely and exclusively in Italy and created by master tailors.


text: Now, there obviously is no dedicated way to actually insert codes into your game (at least nothing has been implemented yet) However, there is a work-around for this. download VisualBoyAdvance for your PC. Grab your save from your sd card ("gametitle".sav), put it in the same directory as the game on your PC, and change the extension from ".sav" to ".sa1" (obviously without the quotes.) Next step is to start the emulator on your PC, load up the game you want to insert code into, then hit file > Import > Battery File... Select your .sa1 file, now you are playing the same game you are on your phone. VisualBoyAdvance has the ability to do Gameshark codes and Codebreaker codes. So insert whatever codes you like, save your game, rename the savefile back to having an extension with a .sav ending, and put the file back in the same directory as the game (on your phone). Tada! Keep in mind that this is just for permanent modifier codes, so it only affects things like item quantity, key items, pokemon, etc., and after you save your game and transfer the save back to your phone, the codes will no longer be in effect, just what you changed when the codes were on. (Also, excuse the poor English structure, I have a lot of percosets in my system right now and I'm not all really here. )


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Apart from the Cherry variety which was launched last year, the other varieties - Apple, Raspberry, Strawberry and Apple & Blackcurrant have been around for some time.
The attention grabbing yellow flash on the top of each box contains the words '1 bake contains 1 portion of fruit'. United Biscuits (UK) who make Go Ahead! have ensured that all Fruit Bakes now contain one portion of fruit. And for those who are weight watching, all varieties have fewer than 132 calories.
What the box says:
'If you're craving a treat, try a delicious Fruit Bake. These golden-baked treats are packed with a range of refreshing fruit flavoured fillings & encased in a delicious wheat biscuit and all under 132 calories.
The Strawberry Go Ahead! Fruit Bake contains the equivalent of at least 80g of fruit (from Apple, Strawberry and Elderberry) where 80g is equivalent to one portion of fruit.
Nutritionally, all Go Ahead! Fruit Bakes contain 13% of an adult's guideline daily recommended sugar intake. All varieties have 3g of fat, 0.7g of saturated fat and 0.2g of salt and all of them have 131 calories apart from the Raspberry which has 130 calories. They're suitable for vegetarians and contain no artificial colours or flavours.
Each box of Go Ahead! Fruit Bakes contains six golden baked bars which can be divided into three pieces. You can find them in the biscuits and cereal bars section of supermarkets.


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With a palpable anti-graft sentiment permeating the country's social and political climate, the drive against corruption has picked up steam in Bihar.
On Sunday, the State government gave a practical demonstration of its anti-corruption law, which entails confiscation and attachment of property belonging to officials accused of corruption under the Bihar Special Courts Act, 2009.
The Patna district administration sealed the property of suspended IAS officer Shiv Shankar Verma, taking possession of his grand residence in Danapur.
Mr. Verma, a Secretary in the Minor Irrigation Department, was suspended after Special Vigilance Unit officials raided his house in 2007 and discovered more than Rs. 1.4 crore in movable and immovable properties.
The law empowers the State government to attach property even during the course of the investigation against an accused. The property can be returned only if the accused is acquitted of all charges.
But the Supreme Court has yet to give its assent to the law, after a Bench stated this May that the accused person's property could be confiscated "only after the offence was proved beyond reasonable doubt."
Following the confiscation, the Chief Minister, however, spelled out the State government's stated intention of transforming the seized property into a school.
Requests of converting seized properties into night shelters for common people, as put forth by the Social Welfare Department, would also be considered, Mr. Kumar said.
The drive spilled over to Monday, with the district administration seizing Mr. Verma's 13 decimal-plot in Alipur village in Patna.
Sixteen more cases regarding confiscation of property are before vigilance courts, with proceedings under way in at least 10 cases, including against a former Director-General of Police.


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- oFono developers claim that its is still a maintained project while rest of the world think its a dead project, even people who love the project. Last release being in 2012 and loads of missing essential features (see rest of the points below) and link to mailing-list broken (even though I pointed it out 3 weeks ago and its been broken for much longer) on the homepage all points to the fact that its essentially a dead project.
- No proper D-Bus introspection nor any client libraries. This already makes it extremely difficult to work with oFono but wait there is more hurdles on the way.
- No online cross-references documentation: The documentation link on the home-page leads you to an architecture diagram and gives you no information about the API. Searching through google doesn't yield any results either. The developers pointed out that all documentation lives in the source tree in the form of plain-text documents and hence not very appropriate for the web.
- It does not implement the standard D-Bus Properties interface. This combined with the fact that their D-Bus API is heavily based on properties makes it yet even harder to work with OFono, not to mention very weird.
- None of the modern 3G modems supported, at least out of the box. I tried both Option and Qualcomm Gobi that I have and they both didn't work.
While rest of the issues can be overcome, the last makes it impossible for me to test any code written against oFono. So I'm giving up on this.
With a nice alternative that is well-maintained, and with which most modems work out of the box, has a nice OO, well-documented and introspectable D-Bus API and also provides a nice client library, I don't understand why phone vendors insist on supporting oFono interface. Could it be because the name makes it sound like its *the* solution for phones? Well, they do have the right to use whatever they like. I'm just curious.
Having said all that, I did make it easy for anyone to add oFono support to Geoclue as promised in my last blog post. Patches to add that are more than welcome!


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Christian Mingle Coupons
- Tuesday, March 08 2016 @ 03:38 pm
- Contributed by: Editor
- Views: 3,669
There are currently no coupon codes available for Christian Mingle for their website or dating app.
What Christian Mingle is offering now is up to 25% off a 3 and 6 month subscription (as of the last time we checked which is January 16, 2018).
Depending on the subscription term length, Christian Mingle subscriptions are as low as $14.99 a month. This sale could expiry at any time so act soon if you are thinking of joining. When you upgrade your free Christian Mingle account the sale prices will be presented to you.
Christian Mingle does also offer further discounts on special occasions. When these discounts are happening we will update this post with more information on how to apply them to your membership. To find out more about this dating service and why it is popular with Christian singles you can read our Christian Mingle review. User reviews of Christian Mingle are also accessible from this page.


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BEERSE, Belgium--(BUSINESS WIRE)--The Janssen Pharmaceutical Companies of Johnson & Johnson today announced results from the Phase 3 MAIA study demonstrating that the addition of daratumumab to lenalidomide and dexamethasone (Rd) significantly reduced the risk of disease progression or death in patients with newly diagnosed multiple myeloma who are ineligible for autologous stem cell transplant (ASCT) (Abstract #LBA-2).1 These data were featured during the late-breaking abstract (LBA) oral session at the 60th American Society of Hematology (ASH) Annual Meeting in San Diego, CA.
"The Phase 3 MAIA study reinforces the clinical profile of daratumumab in combination with a standard of care treatment regimen for newly diagnosed patients with multiple myeloma who are transplant ineligible," said Thierry Facon, M.D., Service des Maladies du Sang, Hôpital Claude Huriez, Lille, France, and principal investigator. "The positive data show the potential role of daratumumab in combination with lenalidomide and dexamethasone as an important new therapeutic approach for this patient population."
At a median follow-up of 28 months, data from the Phase 3 MAIA study showed daratumumab in combination with Rd significantly reduced the risk of disease progression or death by 44 percent in patients with newly diagnosed multiple myeloma who are transplant ineligible compared to treatment with Rd alone (Hazard Ratio [HR] = 0.56; 95 percent confidence interval [CI]: 0.43-0.73; p<0.0001).1 The median progression-free survival (PFS) for daratumumab-Rd has not yet been reached, compared to 31.9 months for patients who received Rd alone.1 The addition of daratumumab resulted in deeper responses compared to Rd alone, including increased rates of complete response (CR) or better (48 percent vs. 25 percent) and improved rates of very good partial response (VGPR) or better (79 percent vs. 53 percent).1 Daratumumab-Rd induced a >3-fold higher rate of minimal residual disease (MRD) negativity compared to those who received Rd alone (24 percent vs. 7 percent).1
"These data underscore the consistent clinical profile observed among newly diagnosed patients with multiple myeloma receiving daratumumab therapy, including for those who are transplant ineligible," said Dr Catherine Taylor, Haematology Therapy Area Lead, Europe, Middle East and Africa (EMEA), Janssen-Cilag Limited. "This is the third study in newly diagnosed patients that has met its primary endpoint and we hope to continue delivering innovative advances to patients with multiple myeloma through our robust clinical research programme, which has the potential to revolutionise cancer treatment by arresting the disease at its earliest stages."
The most common Grade 3/4 treatment-emergent adverse events (TEAEs) for daratumumab-Rd (≥10 percent) included neutropenia (50 percent), lymphopenia (15 percent), pneumonia (14 percent) and anaemia (12 percent).1 Infusion-related reactions (IRRs) occurred in 41 percent of patients, only 3 percent of which were Grade 3/4.1 Incidence of invasive second primary malignancy was 3 percent in the daratumumab-Rd arm compared to 4 percent with Rd alone.1 TEAEs with an outcome of death were 7 percent in the daratumumab-Rd arm compared to 6 percent in the Rd arm.1 The safety profile of daratumumab was consistent with that of previous studies.1
These data will support a future application for marketing authorisation for daratumumab in combination with Rd for this patient population.
About the MAIA Trial1
The randomised, open-label, multicentre Phase 3 study included 737 newly diagnosed patients with multiple myeloma ineligible for high-dose chemotherapy and ASCT aged 45-90 years old (median age of 73). Patients were randomised to receive either daratumumab-Rd or Rd alone in 28-day Cycles. In the daratumumab-Rd treatment arm, patients received daratumumab 16 milligrams per kilogram (mg/kg) IV weekly for Cycles 1 – 2, every two weeks for Cycles 3 – 6 and every 4 weeks for Cycle 7 and thereafter. Patients in the daratumumab-Rd and Rd treatment arm received 25 mg of lenalidomide on Days 1 – 21 of each 28-day Cycle, and dexamethasone at 40 mg once a week for each Cycle. Patients in both treatment arms continued until disease progression or unacceptable toxicity.
About daratumumab
Daratumumab is a first-in-class biologic targeting CD38, a surface protein that is highly expressed across multiple myeloma cells, regardless of disease stage.2 Daratumumab is believed to induce tumour cell death through multiple immune-mediated mechanisms of action, including complement-dependent cytotoxicity (CDC), antibody-dependent cell-mediated cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP), as well as through apoptosis, in which a series of molecular steps in a cell lead to its death.3 A subset of myeloid derived suppressor cells (CD38+ MDSCs), CD38+ regulatory T cells (Tregs) and CD38+ B cells (Bregs) were decreased by daratumumab.3 Daratumumab is being evaluated in a comprehensive clinical development programme across a range of treatment settings in multiple myeloma, such as in frontline and relapsed settings.4,5,6,7,8,9,10,11 Additional studies are ongoing or planned to assess its potential in other malignant and pre-malignant haematologic diseases in which CD38 is expressed, such as smouldering myeloma.12,13 For more information, please see www.clinicaltrials.gov.
In Europe, daratumumab is indicated for use in combination with bortezomib, melphalan and prednisone for the treatment of adult patients with newly diagnosed multiple myeloma who are ineligible for autologous stem cell transplant, as monotherapy for the treatment of adult patients with relapsed and refractory multiple myeloma, whose prior therapy included a proteasome inhibitor and an immunomodulatory agent and who have demonstrated disease progression on the last therapy, and in combination with lenalidomide and dexamethasone, or bortezomib and dexamethasone, for the treatment of adult patients with multiple myeloma who have received at least one prior therapy.3 For further information on daratumumab, please see the Summary of Product Characteristics at http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/004077/WC500207296.pdf.
In August 2012, Janssen Biotech, Inc. and Genmab A/S entered a worldwide agreement, which granted Janssen an exclusive licence to develop, manufacture and commercialise daratumumab.14
About Multiple Myeloma
Multiple myeloma (MM) is an incurable blood cancer that starts in the bone marrow and is characterised by an excessive proliferation of plasma cells.15 More than 45,000 people were diagnosed with multiple myeloma in Europe in 2016, and more than 29,000 patients died.16 Up to half of newly diagnosed patients do not reach five-year survival,17 and almost 29% of patients with multiple myeloma will die within one year of diagnosis.18
Although treatment may result in remission, unfortunately, patients will most likely relapse as there is currently no cure.19 Refractory multiple myeloma is when a patient's disease progresses within 60 days of their last therapy.20,21 Relapsed cancer is when the disease has returned after a period of initial, partial or complete remission.22 While some patients with MM have no symptoms at all, most patients are diagnosed due to symptoms that can include bone problems, low blood counts, calcium elevation, kidney problems or infections.23 Patients who relapse after treatment with standard therapies, including PIs and immunomodulatory agents, have poor prognoses and few treatment options available.24
About the Janssen Pharmaceutical Companies of Johnson & Johnson
At the Janssen Pharmaceutical Companies of Johnson & Johnson, we are working to create a world without disease. Transforming lives by finding new and better ways to prevent, intercept, treat and cure disease inspires us. We bring together the best minds and pursue the most promising science. We are Janssen. We collaborate with the world for the health of everyone in it. Learn more at www.janssen.com/emea. Follow us at www.twitter.com/janssenEMEA for our latest news.
Cilag GmbH International; Janssen Biotech, Inc.; Janssen Oncology, Inc. and Janssen-Cilag International NV are part of the Janssen Pharmaceutical Companies of Johnson & Johnson.
# # #
Cautions Concerning Forward-Looking Statements
This press release contains "forward-looking statements" as defined in the Private Securities Litigation Reform Act of 1995 regarding the benefits of daratumumab for the treatment of patients with multiple myeloma. The reader is cautioned not to rely on these forward-looking statements. These statements are based on current expectations of future events. If underlying assumptions prove inaccurate or known or unknown risks or uncertainties materialise, actual results could vary materially from the expectations and of Janssen-Cilag International NV, Janssen-Cilag Limited, Janssen Biotech, Inc., any of the Janssen Pharmaceutical Companies of Johnson & Johnson and/or Johnson & Johnson. Risks and uncertainties include, but are not limited to: challenges and uncertainties inherent in product research and development, including the uncertainty of clinical success and of obtaining regulatory approvals; uncertainty of commercial success; manufacturing difficulties and delays; competition, including technological advances, new products and patents attained by competitors; challenges to patents; product efficacy or safety concerns resulting in product recalls or regulatory action; changes in behaviour and spending patterns of purchasers of health care products and services; changes to applicable laws and regulations, including global health care reforms; and trends toward health care cost containment. A further list and descriptions of these risks, uncertainties and other factors can be found in Johnson & Johnson's Annual Report on Form 10-K for the fiscal year ended December 31, 2017, including in the sections captioned "Cautionary Note Regarding Forward-Looking Statements" and "Item 1A. Risk Factors," in the company's most recently filed Quarterly Reports on Form 10-Q and in the company's subsequent filings with the Securities and Exchange Commission. Copies of these filings are available online at www.sec.gov, www.jnj.com or on request from Johnson & Johnson. Neither the Janssen Pharmaceutical Companies of Johnson & Johnson nor Johnson & Johnson undertakes to update any forward-looking statement as a result of new information or future events or developments.
1 Facon T, Kumar SJ, Plesner T, et al. Phase 3 Randomized Study of Daratumumab Plus Lenalidomide and Dexamethasone (D-Rd) Versus Lenalidomide and Dexamethasone (Rd) in Patients with Newly Diagnosed Multiple Myeloma (NDMM) Ineligible for Transplant (MAIA). Presented at the 60th Annual Meeting and Exposition of the American Society of Hematology, San Diego, CA, USA, 1-4 December 2018: Oral presentation.
2 Fedele G, di Girolamo M, Recine U, et al. CD38 ligation in peripheral blood mononuclear cells of myeloma patients induces release of protumorigenic IL-6 and impaired secretion of IFNgamma cytokines and proliferation. Mediat Inflamm. 2013;2013:564687.
3 Darzalex summary of product characteristics, October 2018. Available at: https://www.ema.europa.eu/documents/product-information/darzalex-epar-product-information_en.pdf Last accessed November 2018.
4 ClinicalTrials.gov. A study comparing daratumumab, lenalidomide, and dexamethasone with lenalidomide and dexamethasone in relapsed or refractory multiple myeloma. NCT02076009. Available at: https://clinicaltrials.gov/ct2/show/NCT02076009 Last accessed November 2018.
5 ClinicalTrials.gov. Addition of daratumumab to combination of bortezomib and dexamethasone in participants with relapsed or refractory multiple myeloma. NCT02136134. Available at: https://clinicaltrials.gov/ct2/show/NCT02136134 Last accessed November 2018.
6 ClinicalTrials.gov. A study to evaluate daratumumab in transplant eligible participants with previously untreated multiple myeloma (Cassiopeia). NCT02541383. Available at: https://clinicaltrials.gov/ct2/show/NCT02541383 Last accessed November 2018.
7 ClinicalTrials.gov. A study of combination of daratumumab and Velcade (bortezomib) melphalan-prednisone (DVMP) compared to Velcade melphalan-prednisone (VMP) in participants with previously untreated multiple myeloma. NCT02195479. Available at: https://clinicaltrials.gov/ct2/show/NCT02195479 Last accessed November 2018.
8 ClinicalTrials.gov. Study comparing daratumumab, lenalidomide, and dexamethasone with lenalidomide and dexamethasone in participants with previously untreated multiple myeloma. NCT02252172. Available at: https://clinicaltrials.gov/ct2/show/NCT02252172 Last accessed November 2018.
9 ClinicalTrials.gov. A study of Velcade (bortezomib) melphalan-prednisone (VMP) compared to daratumumab in combination with VMP (D-VMP), in participants with previously untreated multiple myeloma who are ineligible for high-dose therapy (Asia Pacific region). NCT03217812. Available at: https://clinicaltrials.gov/ct2/show/NCT03217812 Last accessed November 2018.
10 ClinicalTrials.gov. Comparison of pomalidomide and dexamethasone with or without daratumumab in subjects with relapsed or refractory multiple myeloma previously treated with lenalidomide and a proteasome inhibitor daratumumab/pomalidomide/dexamethasone vs pomalidomide/dexamethasone (EMN14). NCT03180736. Available at: https://clinicaltrials.gov/ct2/show/NCT03180736 Last accessed November 2018.
11 ClinicalTrials.gov. Study of carfilzomib, daratumumab and dexamethasone for patients with relapsed and/or refractory multiple myeloma (CANDOR). NCT03158688. Available at: https://clinicaltrials.gov/ct2/show/NCT03158688 Last accessed November 2018.
12 ClinicalTrials.gov. A study to evaluate 3 dose schedules of daratumumab in participants with smoldering multiple myeloma. NCT02316106. Available at: https://clinicaltrials.gov/ct2/show/NCT02316106 Last accessed November 2018.
13 ClinicalTrials.gov. An efficacy and safety proof of concept study of daratumumab in relapsed/refractory mantle cell lymphoma, diffuse large B-cell lymphoma, and follicular lymphoma. NCT02413489. Available at: https://clinicaltrials.gov/ct2/show/NCT02413489 Last accessed November 2018.
14 Johnson & Johnson. Janssen Biotech announces global license and development agreement for investigational anti-cancer agent daratumumab. Press release August 20, 2012. Available at: http://www.investor.jnj.com/releaseDetail.cfm?releaseid=703517 Last accessed November 2018.
15 American Society of Clinical Oncology. Multiple myeloma: introduction. Available at: https://www.cancer.net/cancer-types/multiple-myeloma/introduction Last accessed November 2018.
16 Cowan AJ, Allen C, Barac A, et al. Global burden of multiple myeloma: a systematic analysis for the Global Burden of Disease Study 2016. JAMA Oncol. 2018;4:1221-1227 + data supplement.
17 De Angelis R, Minicozzi P, Sant M, et al. Survival variations by country and age for lymphoid and myeloid malignancies in Europe 2000-2007: results of EUROCARE-5 population-based study. Eur J Cancer. 2015;51:2254-68.
18 Costa LJ, Gonsalves WI, Kumar SK. Early mortality in multiple myeloma. Leukemia. 2015;29:1616-8.
19 Abdi J, Chen G, Chang H, et al. Drug resistance in multiple myeloma: latest findings and new concepts on molecular mechanisms. Oncotarget. 2013;4:2186–207.
20 National Cancer Institute. NCI dictionary of cancer terms: refractory. Available at: https://www.cancer.gov/publications/dictionaries/cancer-terms?CdrID=350245 Last accessed November 2018.
21 Richardson P, Mitsiades C, Schlossman R, et al. The treatment of relapsed and refractory multiple myeloma. Hematology Am Soc Hematol Educ Program. 2007:317-23.
22 National Cancer Institute. NCI dictionary of cancer terms: relapsed. Available at: https://www.cancer.gov/publications/dictionaries/cancer-terms?CdrID=45866 Last accessed November 2018.
23 American Cancer Society. Multiple myeloma: early detection, diagnosis and staging. Available at: https://www.cancer.org/content/dam/CRC/PDF/Public/8740.00.pdf Last accessed November 2018.
24 Kumar SK, Lee JH, Lahuerta JJ, et al. Risk of progression and survival in multiple myeloma relapsing after therapy with IMiDs and bortezomib: a multicenter international myeloma working group study. Leukemia. 2012;26:149-57.
December 2018


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Listings in Quantitative Research, Event/Experiential Marketing Consultants, Health Care/Pharma Marketing Consultants, Celebrity Marketing Services, Healthcare/Pharma Research, Full Service Marketing Communications, Customized Training and Audio/Video Conferencing in Anchorage
McDowell Group, Inc. (Br.)
1400 W. Benson Blvd.
Suite 350
Anchorage, Alaska
United States of America
Innovate Solutions
in Event/Experiential Marketing Consultants, Digital Marketing Consultants, Full Service Advertising, Sales Training, Copywriting
PO Box 112765
Anchorage, Alaska 99511
United States of America


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There is something unique about data visualization and infographics that can really get a message across, especially The World of 100 project by Toby Ng Design. According to brain pickings, "the power of this smart graphic design coneys big concepts that are otherwise hard to grasp in their raw numberness." The idea takes the entire globe and puts demographics like literacy, freedom, food, religion, and computers onto a scale of just 100 people. The design is very simple and uncomplicated, using bright colors to get the powerful message across. Some of the numbers are truly mind-boggling, for example of our awesome little settlement of 100, only 1 has a college education. Also, 48 can't speak or act according to their faith and conscience due to harassment, imprisonment, torture or death. Look below, this is the world we are living in.
Photos were taken from the Toby Ng Design website, you can see all of his work here!


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"Families don't have to match. You don't have to look like someone else to love them." -Leigh Anne Tuohy, adoptive mother of Michael Oher, as portrayed by Sandra Bullock in The Blind Side.
For more than 60 years we've been helping individuals and couples build their families through adoption. We understand the complex emotions and challenging choices families considering adoption face. That's why we're there every step of the way, from clarifying the options available to prospective parents to helping navigate the adoption process itself. We provide a full range of services for all members of the adoption triad—birthparents and adoptive parents, with the child at the center of everything we do. We counsel potential birthparents about all their options, conduct homestudies for adoptive parents in all three of our adoption programs, provide adoption education for parents in process, and provide post-placement services and referrals to community resources to ensure the best possible outcome for children and families. Our Adoption & Children's Services Department has been operating continuously since 1953. Our many years of adoption work mean that we have had decades to build relationships with adoption attorneys, adoptive parent support groups, and other agencies providing placement services for babies and older children who need families. Our connections to the broader adoption community enable A&CS to continuously update our procedures to reflect the most current information in adoption law, research, and practice. We provide depth of experience combined with breadth of contacts. We are fully accredited by the Council of Accreditation of Services for Families & Children and we are an authorized agency with the State of New York. Our experienced, caring and professional staff of licensed social workers have expertise in the field of adoption, as well as family guidance and counseling. We are available to you seven days a week to answer your questions throughout the adoption experience. Our mission is to support you as you build your family through adoption.
FREE Adoption Orientations
Adoption & Children's Services offers free monthly Adoption Orientations. It is required that all pre-adoptive applicants attend one orientation before beginning the homestudy process. The next Orientation session will take place on Tuesday, November 19, 2019, from 6:00 PM – 8:00 PM at the Center for All Ages – 106 North Broadway, White Plains, NY 10603.
If you would like to let us know that you are planning to attend an upcoming Orientation, please fill out the Orientation Reservation Form.
If you or your partner is pregnant and considering making an adoption plan, and you want to see our families who are approved to adopt, click here.
For more information regarding our adoption program, please contact:
Mia Diamond Padwa, Director
(914) 274-8334 x232
78 Main Street
Hastings-on-Hudson, NY 10706


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Maylaysia Travel Information – Travel in Malaysia
Malaysiatravel.info is a travel website introducing interesting information about popular destinations in Malaysia. Through this website, tourists will know about the receipt and ingredient of unique Malaysia's food such as Lontong, Nasi dagang and Murtabak. From the list of the website, you can choose a good hotel in different areas in Malaysia. There are a number of hotels and resorts here with different features, services and quality. Besides, the website shows detailed description of famous destinations Gomantong caves or Tioman Island.


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Sometimes we just need our coats to keep us warm, but sometimes we need them to be relatively smart, too, so for those times when you're off out for the evening and don't want to throw on your regular old "day to day" coat over your slinky dress, this brocade coat by JJ Park could be the answer.
The brocade fabric and satin trim give this a bit of a luxurious feel, while the wool content will make it fairly warm at the same time. It'll look good for dressier occasions, but could be equally good over a pair of jeans or whatever you normally wear to work, too.
Get it at Oli, where it's £125.


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The Alternative Splice Variant of Protein Tyrosine Kinase 6 Negatively Regulates Growth and Enhances PTK6-Mediated Inhibition of beta-Catenin
Brauer, Patrick M.
Zheng, Yu
Evans, Mark D.
Dominguez-Brauer, Carmen
Peehl, Donna M.
Tyner, Angela L.
PublisherPublic Library of Science
MetadataShow full item record
Protein tyrosine kinase 6 (PTK6), also called breast tumor kinase (BRK), is expressed in epithelial cells of various tissues including the prostate. Previously it was shown that PTK6 is localized to epithelial cell nuclei in normal prostate, but becomes cytoplasmic in human prostate tumors. PTK6 is also primarily cytoplasmic in the PC3 prostate adenocarcinoma cell line. Sequencing revealed expression of wild type full-length PTK6 transcripts in addition to an alternative transcript lacking exon 2 in PC3 cells. The alternative transcript encodes a 134 amino acid protein, referred to here as ALT-PTK6, which shares the first 77 amino acid residues including the SH3 domain with full length PTK6. RT-PCR was used to show that ALT-PTK6 is coexpressed with full length PTK6 in established human prostate and colon cell lines, as well as in primary cell lines derived from human prostate tissue and tumors. Although interaction between full-length PTK6 and ALT-PTK6 was not detected, ALT-PTK6 associates with the known PTK6 substrates Sam68 and b-catenin in GST pull-down assays. Coexpression of PTK6 and ALT-PTK6 led to suppression of PTK6 activity and reduced association of PTK6 with tyrosine phosphorylated proteins. While ALT-PTK6 alone did not influence b-catenin/TCF transcriptional activity in a luciferase reporter assay, it enhanced PTK6-mediated inhibition of b-catenin/TCF transcription by promoting PTK6 nuclear functions. Ectopic expression of ALTPTK6 led to reduced expression of the b-catenin/TCF targets Cyclin D1 and c-Myc in PC3 cells. Expression of tetracyclineinducible ALT-PTK6 blocked the proliferation and colony formation of PC3 cells. Our findings suggest that ALT-PTK6 is able to negatively regulate growth and modulate PTK6 activity, protein-protein associations and/or subcellular localization. Fully understanding functions of ALT-PTK6 and its impact on PTK6 signaling will be critical for development of therapeutic strategies that target PTK6 in cancer.
Subjectbreast tumor kinase
prostate cancer
gastrointestinal tract
androgen receptor
oxidative stress
distinct family


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Markov Chain Generator
This demo generates a Markov Chain with probabilities based on supplied classical books.
Markov Chain is a stochastic model describing a sequence of possible events in which the probability of each event depends only on the state attained in the previous event.
To build the Markov Chain, Jet reads the books stored in text files and converts consecutive words to pairs. To compute the probability of finding word B after A, one has to know how many pairs contain word A as a first entry and how many of them contain B as a second entry. The aggregation features of Jet are used to do the heavy lifting. Jet runs the computation in parallel to make use of all available processor cores.
The chain is then used to generate random sentences.


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We had a wonderful time at City Cycling in Alexandria and Arlington last weekend. This is what it looked like:
Our next session in this series is a Community Ride in Arlington on April 22.
(Or read about our ride series here.)
Big thanks to everyone who participated and taught last weekend! Find upcoming classes in your area here.


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In a midrash on the opening of this week's parashah, Vayeira, the rabbis suggest that God pays a visit to Abraham as he lies, recuperating, at the opening of his tent. This first act of bikur cholim establishes a model for our people to see, hear and respond immediately and personally to the suffering of others. During these difficult days, we pray for those stricken by the devastation of Hurricane Sandy and for those who have committed themselves to responding to their need.
We pray that those who suffer find comfort through their faith in You and through the loving kindness of those emergency workers and volunteers who have come to their aid.
We pray that those who have lost so much have the fortitude to rebuild their lives. Let us seek out ways to help them build their tents anew and make of them, once again, havens of healing and hospitality. May all who have been battered by this storm discover many hearts and hands open to them. None of us stands alone in times of trouble.
Baruch Atah, Adonai, magein Avraham v'ezrat Sarah. Blessed are You, Adonai, shield of Abraham, help of Sarah. Baruch Atah Adonai, ozer Yisrael b'guvrah: Blessed are You, Adonai. You are the Source of our strength.
Many hands and hearts contributed to this prayer.