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Winless no more: LeBron won his first NBA Championship in mens nike 2012, easily handling the energetic and talented Oklahoma City Thunder in just five games. During the series, LeBron whipped out one of the best in-game Player Exclusives we ve ever laid eyes on the Red/Black/Gold Nike LeBron 9 Elite. After the Ring was secured, Nike released the shoes as part of the two-pair Pack the other shoe honoring LeBron s third NBA MVP Award.
The Summer of 2012 was an incredible time for LeBron James. After taking home the NBA MVP Award, his first Championship Ring, and his first NBA Finals MVP Award, LeBron James got back to work with Team USA and battled the world at the Olympics in London. Throughout the Games, LeBron wore the next-gen Nike Lunar Hyperdunk , which featured Nike s all-new Nike Basketball technology, but for the Gold Medal Game against Spain, he offered up a first look at mens nike air max the Nike LeBron X , which also featured the amazing tech-y capabilities.
We re less than two weeks away from the annual Air Max Day celebration on March 26th. In honor of the occasion, Nike invited us out to their Portland, Oregon World Headquarters to celebrate the Air Max legacy. The Swoosh pulled out nike 2017 all of the stops, unveiling classic sketches of their initial models, showcasing never before seen prototypes telling the unique narrative of each shoe s creation, and displaying a wide array of each Air Max unit from the origins of the Air Max 1 all the way to the current 360 degree air bags. Two key innovators in the creation of the nearly three decade technology, Tinker Hatfield and David Forland were on site to give us their insights and recall how exactly we got to the point where Air Max is a staple in the sneaker community.
What do you think of the latest Air nike 2017 shoes Force 1 ? Check out more photos below and be on the lookout for this pair to hit retailers later this Spring 2016.This year s Superbowl collection of sneakers from Nike is not one concerned strictly with performance models. Filling out the retro category is the Nike Knows collection, which sports some of the same silvery touches and that logo specially crafted for the upcoming NYC-area Superbowl. Included are the Nike Air Trainer 1 , the Nike Lunar 180 Trainer SC , the Nike Air Trainer Max 94 , the Nike Zoom Meriwether Posite , and the Nike Dunk Sky High Premium.
Continue reading to see each of these sneakers from the upcoming Nike Knows pack and watch for the shoes in stores come late January (Save for the Lunar pair of Bo Jacksons, which is already up for grabs).The Nike Knows collection is inspired by a golden age, a time when athletes were elevated to heights previously unknown and their legacy expanded well beyond the field. While winning was the core motive, swagger was a prerequisite. The dynamic personas of the era elevated a game into the game. Cross training was the new frontier. Home plate was where bats were broken.
Evoking the legend of football and training stars, Nike cheap nike shoes Knows sets the stage for the next generation of larger-than-life athletes. The collection champions those making an impact on the diamond, gridiron and the octagon reminding us all that resilience in practice leads to epic feats on the field, and that game-changing innovation is at the heart of Nike training. Find out more about the Nike Knows Collection here.Laker fans get some new hope next season as the team is about to get the second pick in this year s particularly stacked NBA draft, but no fan s dreams will be complete until Kobe is back on the floor.


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Holiday Dark Lip & Gold Eyes Tutorial | SILVER/GREY HAIR | Ashley Bond Beauty
hey guys welcome back to my channel today I am really excited to do this festive holiday makeup look for you guys so you guys may have noticed that something is a little bit different and its because I've dyed my hair I decided to dye my hair this silver color and I am absolutely obsessed with it I'm only kidding guys you know I didn't dye my hair you know I didn't dye my hair I decided to get a wig because I was craving a change and I just wanted a temporary change I didn't want permanent heat damage I didn't want to cut my hair or anything like that and I bought this wig I've always likes sliver hair I love how it looks on people so… I wanted to try it out and see how it would look on me I feel like I'm Storm from X-men which, I'm not hating it. Ha. Ha this isn't something I would wear out in public, I mean maybe if I was going to the club and no one could see me in the lights I don't know If you guys were wondering if I dyed my hair don't worry My hair is safe and sound in a ball in the back of this wig lol more curly hair videos to come very very soon for you guys so no worries on that so enough talking if you guys want to see how I achieve this look right here Just keep on watching and make sure you give this video a thumbs up if you enjoy and subscribe for new videos every week so lets jump right in First we are going to start off with foundation I am using this Nars luminous all day foundation and I'm just going to be using three drops all over my face this foundation is amazing it lasts all day Its super light weight and it gives great coverage and I'm going to be buffing that in with the elf buffing brush next I'm taking this NYX dark circle concealer and I'm just going to be placing that underneath my eyes as you can see it really just brightens up underneath my eyes and color corrects any darkness I love this stuff, super inexpensive once I'm finished with that I'm going to be going in with Mac pro longwear concealer you guys have seen me do this a million times because this is my all time favorite concealer I don't know what I would do without it I'm just going to be placing that underneath my eyes and in my t-zone to highlight then I'm going to be blending it out with a damp beauty blender once that is finished I'm going to be taking my LA girl Pro concealer and I'm going to be placing that right on top I'm just going to be placing that underneath my eyes and in my t-zone again the mix of these concealers works really well together and give me my perfect highlight shade once that is finished you are going to at to set my under eye concealer immediately so it doesn't crease we are just going to be using the baking method and I'm just going to be placing a lot of powder underneath my eyes so that everything is set in place and I'm just going to set my t-zone as well and I'm just going to let that bake while we do brows and contour I'm going to be taking my Mac studio Fix powder and I got a little kiss from bae and I'm just going to be taking that and contouring my face I'm just going to be doing a light contour I'm just going to be warming up the outer perimeter of my face as of lately I haven't been into a strong contour I just like warming up my face I like my face to look pretty natural I'm also going to take that same shade and contour my nose once that is finished I'm going to be dusting off and access powder and just buffing everything out I'm going to be priming my eyes with mac soft ochre paint pot I'm going into the Anastasia Beverly Hills Self-made pallete and I'm going to be taking self made and placing that all over my lid next i'm going to be taking the hot chocolate shade I'm going to be taking the buffing brush that came in the palette and I'm going to be buffing that into my crease once that is finished I'm going in with the betty lou-manizer highlighter and I'm just taking that in my finger and I'm placing that in the center of my eye this just gives a nice pop of gold to the center of the eye it actually turned out really nice and then I'm going back in with the fluffy brush and just to blend everything out and make sure there is no harsh lines next I'm going to be taking my wet and wild liquid liner and I'm going to be giving myself a dramatic wing practice makes perfect when it comes to winged liner so if you don't get it on the first time, don't give up, practice makes perfect next I'm taking the elf blush palette in deep and I'm just taking this shimmery peachy pink shade and i'm just going to be buffing that onto my cheeks not time for lips i'm going to be using vino by mac and I'm just going to be lining my lips for the next lip color and for the star of the show I'm going to be using the colourpoplippie stick in silk this shade is the perfect holiday shade in my opinion I just think it is so beautiful Its not too dark, and its not too red its just the perfect holiday shade I don't know why this caught my eye when I was shopping on colourpops website but I'm really glad I got it Next I'm going to be highlighting using the betty lou-manizer highlighter and I'm also going to be placing that on the center of my nose off camera I applied christina lashes and here is the final look thank you guys so much for watching I hope you enjoyed this holiday makeup look and I hope you guys have a great holiday season as always please make sure to like, comment, share and subscribe if you enjoy I'm trying to get a new video out for you guys every week so requests are always welcome again thank you guys so much for watching and I will see you guys next time bye guys!

subset: commoncrawl


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Dutch artist Suzan Visser has created a series of wonderful works with birds featured in imaginative settings. Included in that series is this adorable sparrow wearing a winter hat. The artist entitled this work Winter Sparrow. Available as a postcard only.
- 5¾'' wide x 4'' tall
- Available as a postcard only
Winter Sparrow Postcard by Suzan Visser
$2.00 Regular Price
$1.60Sale Price


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Chemical explosions in the Chinese port city of Tianjin sent enormous fireballs and thick acrid smoke into the air on Thursday, shattering windows miles away. The death toll climbed to at least 50 on Thursday with more than 700 injured. The blasts occurred at a warehouse stocked with hazardous chemicals.
The Guardian's Fergus Ryan arrived on the scene hours after the blasts. "I saw huge chunks of metal that had been stripped from shipping containers and had been flung over the highway. They had flown 500 meters to land jutting out of the ground."
An initial explosion triggered a second, even bigger one. The National Earthquake Bureau said the first blast was the equivalent of 3 tons of TNT, and the second 21 tons. "As I got closer to the blast zone, I saw underneath the highway scores of trucks and cars that were parked underneath the highway," said Ryan. "All of the windows had been smashed and the vehicles had been blackened. There was glass all over the ground."
Enormous fireballs from the blasts had rolled through a nearby parking lot, turning a fleet of 1,000 new cars into scorched metal shells.
Initially, more than 1,000 firefighters were sent to the industrial zone in Tianjin, a petrochemical processing hub about 75 miles east of Beijing. Tianjin is an important port in China, handling vast amounts of metal ore, coal, steel, cars and crude oil.
As Ryan made his way through the wreckage, he could see dozens of contorted shipping containers and lots of smoke. "I could also see huge plumes of what started off as white smoke billowing out of the area but then suddenly turned yellow." And he noticed a strange smell. "Definitely when I was right up very close to the blast scene, there was a very acrid smell and the color of the smoke coming out from the blast zone was unusual."
Amid the commotion, Ryan saw signs of goodwill. "Outside of hospitals, there were people with supplies, bottles of water and food. There were also fleets of taxis who were taking victims and their families to and from the hospital for free."
Chinese authorities say the warehouse where the blasts occurred belongs to Ruihai Logistics, a company that stores hazardous and flammable petrochemicals, sodium cyanide and toluene diisocyanate.
The cause of the disaster is not yet known, but China has a history of problems with the enforcement of safety and environmental regulations.
On paper, China's safety regulations are pretty good, according to The World's former Beijing correspondent, Mary Kay Magistad. "They've improved a lot over the past decade. In practice, a lot of local governments feel that it's easier for local enterprises, local companies, if they don't enforce them too stringently because there's more room for profit. If there's more profit, it looks better for the local officials when they put in for a promotion."
The central government is aware of this pressure, Magistad says. "But in the middle of an economic slowdown, which China is in right now, the government is concerned about the bottom line. The government is concerned to some degree about the safety of its citizens, but is also concerned about delivering economic growth. And sometimes the signals that go down to the local level are stronger on [profit] than on [safety]."
The situation is never clear, even at the local level. "Parts of the local government," says Magistad, "might think that environmental safety standards are being enforced. But people in other departments with a wink and a nod say we don't really need to do this. Or just through neglect, not even through a positive decision, but through just not being very pro-active in enforcing the regulations could let something happen that shouldn't have happened."
The Chinese people are not happy with this, to say the least. But a civil society movement that had been scoring successes in the effort to clean up the environment and improve attention to safety issues, has been stifled under the new government of President Xi Jinping.


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A 20-year-old man was killed by police while he was asleep in his car.
Officers in Vallejo, California responded to a report of a man who had fallen asleep in the drive-thru line of a Taco Bell at roughly 10:30 pm on February 9.
According to police, the doctors were locked and the car was on. The driver who was identified by family members as Willie McCoy, was unresponsive with a handgun in his lap.
Police say that McCoy suddenly moved and that he "quickly moved his hands downward for the firearm." Six officers fired "multiple rounds" and McCoy died at the scene.
The victim, also known by his rapper name Willie Bo, was "passionate" and "very ambitious" about music according to his brother. His family is demanding criminal prosecution of the officers involved.
"There was no attempt to try to work out a peaceful solution," said his brother Marc. "The police's job is to arrest people who are breaking the law—not take the law into you own hands. You're not judge, jury and executioner…We're never going to get over this."
And autopsy of McCoy is pending.


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About two years ago I started to notice a strange pattern emerge. If I hear Phish on the radio, there is about a 75% chance that David will contact me somehow that day. This becomes even more true the longer I haven't heard from him. Now, I don't know if this is a testament to the infrequency of Phish being played on the radio, or maybe the rate of communication between the two of us, and perhaps it's a bit of both, but it's still pretty interesting.*
So today as I was driving to work, "Down with Disease" came on the radio. As I rode down Lyndale I thought to myself "hmm, wonder how David's doing?" I had talked to him back at the end of March when I drunk dialed him at an ungodly hour, but before that not since February (fun fact - I slept through his call a day that I heard "Heavy Things" on my way back from work). Anyways - seven hours later I get a text message from him saying that he just got accepted to the Grad Program at San Jose State University!
David worked really hard on his application to SJSU as well as being a pretty darn good social worker. So if it compels you - go over to deeprizendragon and congratulate a total stranger on getting into Grad School. He really does deserve it.
In the meantime, I'm going to listen to some Phish and chill out on this wet and rainy Monday evening.
*This rate is not true for me contacting David, however. The odds of me drunk dialing him on a Friday evening are about as good as hearing a Brittany Spears song on air. Probably with the same visceral reaction too.


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Muscle trauma is highly morbid due to intramuscular scarring, or fibrosis, and muscle atrophy. Studies have shown that bone morphogenetic proteins (BMPs) reduce muscle atrophy. However, increased BMP signaling at muscle injury sites causes heterotopic ossification, as seen in patients with fibrodysplasia ossificans progressiva (FOP), or patients with surgically placed BMP implants for bone healing. We use a genetic mouse model of hyperactive BMP signaling to show the development of intramuscular fibrosis surrounding areas of ectopic bone following muscle injury. Rapamycin, which we have previously shown to eliminate ectopic ossification in this model, also eliminates fibrosis without reducing osteogenic differentiation, suggesting clinical value for patients with FOP and with BMP implants. Finally, we use reporter mice to show that BMP signaling is positively associated with myofiber cross-sectional area. These findings underscore an approach in which 2 therapeutics (rapamycin and BMP ligand) can offset each other, leading to an improved outcome.
Shailesh Agarwal, David Cholok, Shawn Loder, John Li, Christopher Breuler, Michael T. Chung, Hsiao Hsin Sung, Kavitha Ranganathan, Joe Habbouche, James Drake, Joshua Peterson, Caitlin Priest, Shuli Li, Yuji Mishina, Benjamin Levi
Obesity is associated with increased classically activated M1 adipose tissue macrophages (ATMs) and decreased alternatively activated M2 ATMs, both of which contribute to obesity-induced inflammation and insulin resistance. However, the underlying mechanism remains unclear. We find that inhibiting DNA methylation pharmacologically using 5-aza-2′-deoxycytidine or genetically by DNA methyltransferase 1 (DNMT1) deletion promotes alternative activation and suppresses inflammation in macrophages. Consistently, mice with myeloid DNMT1 deficiency exhibit enhanced macrophage alternative activation, suppressed macrophage inflammation, and are protected from obesity-induced inflammation and insulin resistance. The promoter and 5′-untranslated region of peroxisome proliferator-activated receptor γ1 (PPARγ1) are enriched with CpGs and are epigenetically regulated. The saturated fatty acids stearate and palmitate and the inflammatory cytokine TNF-α significantly increase, whereas the TH2 cytokine IL-4 significantly decreases PPARγ1 promoter DNA methylation. Accordingly, inhibiting PPARγ1 promoter DNA methylation pharmacologically using 5-aza-2′-deoxycytidine or genetically by DNMT1 deletion promotes macrophage alternative activation. Our data therefore establish DNA hypermethylation at the PPARγ1 promoter induced by obesity-related factors as a critical determinant of ATM proinflammatory activation and inflammation, which contributes to insulin resistance in obesity.
Xianfeng Wang, Qiang Cao, Liqing Yu, Huidong Shi, Bingzhong Xue, Hang Shi
Chronic inflammation with mucous metaplasia and airway remodeling are hallmarks of allergic asthma, and these outcomes have been associated with enhanced expression and activation of EGFR signaling. Here, we demonstrate enhanced expression of EGFR ligands such as amphiregulin as well as constitutive EGFR activation in cultured nasal epithelial cells from asthmatic subjects compared with nonasthmatic controls and in lung tissues of mice during house dust mite–induced (HDM-induced) allergic inflammation. EGFR activation was associated with cysteine oxidation within EGFR and the nonreceptor tyrosine kinase Src, and both amphiregulin production and oxidative EGFR activation were diminished by pharmacologic or genetic inhibition of the epithelial NADPH oxidase dual oxidase 1 (DUOX1). DUOX1 deficiency also attenuated several EGFR-dependent features of HDM-induced allergic airway inflammation, including neutrophilic inflammation, type 2 cytokine production (IL-33, IL-13), mucous metaplasia, subepithelial fibrosis, and central airway resistance. Moreover, targeted inhibition of airway DUOX1 in mice with previously established HDM-induced allergic inflammation, by intratracheal administration of DUOX1-targeted siRNA or pharmacological NADPH oxidase inhibitors, reversed most of these outcomes. Our findings indicate an important function for DUOX1 in allergic inflammation related to persistent EGFR activation and suggest that DUOX1 targeting may represent an attractive strategy in asthma management.
Aida Habibovic, Milena Hristova, David E. Heppner, Karamatullah Danyal, Jennifer L. Ather, Yvonne M.W. Janssen-Heininger, Charles G. Irvin, Matthew E. Poynter, Lennart K. Lundblad, Anne E. Dixon, Miklos Geiszt, Albert van der Vliet
Diana Golden, Antonina Kolmakova, Sunitha Sura, Anthony T. Vella, Ani Manichaikul, Xin-Qun Wang, Suzette J. Bielinski, Kent D. Taylor, Yii-Der Ida Chen, Stephen S. Rich, Annabelle Rodriguez
The challenge of translating findings from animal models to the clinic is well known. An example of this challenge is the striking effectiveness of neurokinin-1 receptor (NK-1R) antagonists in mouse models of inflammation coupled with their equally striking failure in clinical investigations in humans. Here, we provide an explanation for this dichotomy: Mas-related GPCRs (Mrgprs) mediate some aspects of inflammation that had been considered mediated by NK-1R. In support of this explanation, we show that conventional NK-1R antagonists have off-target activity on the mouse receptor MrgprB2 but not on the homologous human receptor MRGPRX2. An unrelated tripeptide NK-1R antagonist has dual activity on MRGPRX2. This tripeptide both suppresses itch in mice and inhibits degranulation from the LAD-2 human mast cell line elicited by basic secretagogue activation of MRGPRX2. Antagonists of Mrgprs may fill the void left by the failure of NK-1R antagonists.
Ehsan Azimi, Vemuri B. Reddy, Kai-Ting C. Shade, Robert M. Anthony, Sebastien Talbot, Paula Juliana Seadi Pereira, Ethan A. Lerner
Development of novel treatments for lymphedema has been limited by the fact that the pathophysiology of this disease is poorly understood. It remains unknown, for example, why limb swelling resulting from surgical injury resolves initially, but recurs in some cases months or years later. Finding answers for these basic questions has been hampered by the lack of adequate animal models. In the current study, we used
Jason C. Gardenier, Geoffrey E. Hespe, Raghu P. Kataru, Ira L. Savetsky, Jeremy S. Torrisi, Gabriela D. García Nores, Joseph J. Dayan, David Chang, Jamie Zampell, Inés Martínez-Corral, Sagrario Ortega, Babak J. Mehrara
Oxidative stress is implicated in various neurodegenerative disorders, including retinitis pigmentosa (RP), an inherited disease that causes blindness. The biological and cellular mechanisms by which oxidative stress mediates neuronal cell death are largely unknown. In a mouse model of RP (rd10 mice), we show that oxidative DNA damage activates microglia through MutY homolog–mediated (MUYTH-mediated) base excision repair (BER), thereby exacerbating retinal inflammation and degeneration. In the early stage of retinal degeneration, oxidative DNA damage accumulated in the microglia and caused single-strand breaks (SSBs) and poly(ADP-ribose) polymerase activation. In contrast,
Shunji Nakatake, Yusuke Murakami, Yasuhiro Ikeda, Noriko Morioka, Takashi Tachibana, Kohta Fujiwara, Noriko Yoshida, Shoji Notomi, Toshio Hisatomi, Shigeo Yoshida, Tatsuro Ishibashi, Yusaku Nakabeppu, Koh-Hei Sonoda
Transgenic expression of key myelosupportive human cytokines in immune-deficient mice corrects for the lack of cross-species activities of stem cell factor (SCF), IL-3, and GM-CSF. When engrafted with human umbilical cord blood (UCB), these triple-transgenic mice produce BM and spleen grafts with much higher myeloid composition, relative to nontransgenic controls. Shortly after engraftment with UCB, these mice develop a severe, fatal macrophage activation syndrome (MAS) characterized by a progressive drop in rbc numbers, increased reticulocyte counts, decreased rbc half-life, progressive cytopenias, and evidence of chronic inflammation, including elevated human IL-6. The BM becomes strikingly hypocellular, and spleens are significantly enlarged with evidence of extramedullary hematopoiesis and activated macrophages engaged in hemophagocytosis. This manifestation of MAS does not respond to lymphocyte-suppressive therapies such as steroids, i.v. immunoglobulin, or antibody-mediated ablation of human B and T cells, demonstrating a lymphocyte-independent mechanism of action. In contrast, elimination of human myeloid cells using gemtuzumab ozogamicin (anti-CD33) completely reversed the disease. Additionally, the IL-6R antibody tocilizumab delayed progression and prolonged lifespan. This new model of MAS provides an opportunity for investigation of the mechanisms driving this disease and for the testing of directed therapies in a humanized mouse.
Mark Wunderlich, Courtney Stockman, Mahima Devarajan, Navin Ravishankar, Christina Sexton, Ashish R. Kumar, Benjamin Mizukawa, James C. Mulloy
BACKGROUND. Alopecia areata (AA) is an autoimmune disease characterized by hair loss mediated by CD8+ T cells. There are no reliably effective therapies for AA. Based on recent developments in the understanding of the pathomechanism of AA, JAK inhibitors appear to be a therapeutic option; however, their efficacy for the treatment of AA has not been systematically examined.
METHODS. This was a 2-center, open-label, single-arm trial using the pan-JAK inhibitor, tofacitinib citrate, for AA with >50% scalp hair loss, alopecia totalis (AT), and alopecia universalis (AU). Tofacitinib (5 mg) was given twice daily for 3 months. Endpoints included regrowth of scalp hair, as assessed by the severity of alopecia tool (SALT), duration of hair growth after completion of therapy, and disease transcriptome.
RESULTS. Of 66 subjects treated, 32% experienced 50% or greater improvement in SALT score. AA and ophiasis subtypes were more responsive than AT and AU subtypes. Shorter duration of disease and histological peribulbar inflammation on pretreatment scalp biopsies were associated with improvement in SALT score. Drug cessation resulted in disease relapse in 8.5 weeks. Adverse events were limited to grade I and II infections. An AA responsiveness to JAK/STAT inhibitors score was developed to segregate responders and nonresponders, and the previously developed AA disease activity index score tracked response to treatment.
CONCLUSIONS. At the dose and duration studied, tofacitinib is a safe and effective treatment for severe AA, though it does not result in a durable response. Transcriptome changes reveal unexpected molecular complexity within the disease.
TRIAL REGISTRATION. ClinicalTrials.gov NCT02197455 and NCT02312882.
FUNDING. This work was supported by the US Department of Veterans Affairs Office of Research and Development, National Institute of Arthritis and Musculoskeletal and Skin Diseases National Institutes of Health grant R01 AR47223 and U01 AR67173, the National Psoriasis Foundation, the Swedish Society of Medicine, the Fernström Foundation, the Locks of Love Foundation, the National Alopecia Areata Foundation, and the Ranjini and Ajay Poddar Resource Fund for Dermatologic Diseases Research.
Milène Kennedy Crispin, Justin M. Ko, Brittany G. Craiglow, Shufeng Li, Gautam Shankar, Jennifer R. Urban, James C. Chen, Jane E. Cerise, Ali Jabbari, Mårten C.G. Winge, M. Peter Marinkovich, Angela M. Christiano, Anthony E. Oro, Brett A. King
GWAS have linked SNPs to risk of inflammatory bowel disease (IBD), but a systematic characterization of disease-associated genes has been lacking. Prior studies utilized microarrays that did not capture many genes encoded within risk loci or defined expression quantitative trait loci (eQTLs) using peripheral blood, which is not the target tissue in IBD. To address these gaps, we sought to characterize the expression of IBD-associated risk genes in disease-relevant tissues and in the setting of active IBD. Terminal ileal (TI) and colonic mucosal tissues were obtained from patients with Crohn's disease or ulcerative colitis and from healthy controls. We developed a NanoString code set to profile 678 genes within IBD risk loci. A subset of patients and controls were genotyped for IBD-associated risk SNPs. Analyses included differential expression and variance analysis, weighted gene coexpression network analysis, and eQTL analysis. We identified 116 genes that discriminate between healthy TI and colon samples and uncovered patterns in variance of gene expression that highlight heterogeneity of disease. We identified 107 coexpressed gene pairs for which transcriptional regulation is either conserved or reversed in an inflammation-independent or -dependent manner. We demonstrate that on average approximately 60% of disease-associated genes are differentially expressed in inflamed tissue. Last, we identified eQTLs with either genotype-only effects on expression or an interaction effect between genotype and inflammation. Our data reinforce tissue specificity of expression in disease-associated candidate genes, highlight genes and gene pairs that are regulated in disease-relevant tissue and inflammation, and provide a foundation to advance the understanding of IBD pathogenesis.
Joanna M. Peloquin, Gautam Goel, Lingjia Kong, Hailiang Huang, Talin Haritunians, R. Balfour Sartor, Mark J. Daly, Rodney D. Newberry, Dermot P. McGovern, Vijay Yajnik, Sergio A. Lira, Ramnik J. Xavier
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Lidia's Celebrate Like an Italian: 220 Foolproof Recipes That Make Every Meal a Party: A Cookbook
Lidia's Celebrate Like an Italian: 220 Foolproof Recipes
The beloved TV chef offers the only cookbook you'll need to give any gathering--from a dinner for two to a wedding--a delectable, welcoming Italian flavor. No one throws a party like Lidia Bastianich! And now, in this delightful new cookbook, she gives us 220 fantastic recipes for entertaining with that distinctly Bastianich flare. From Pear Bellinis to Carrot and Chickpea Dip, from Campanelle with Fennel and Shrimp to Berry Tiramisu--these are dishes your guests will love, no matter the occasion. Here, too, are Lidia's suggestions for hosting a BBQ, making pizza for a group, choosing the perfect wine, setting an inviting table, and much more. Beautifully illustrated throughout with full-color photographs and filled with her trademark warmth and enthusiasm, this is Lidia's most festive book. Whether you're planning a romantic picnic for two, a child's birthday party, a holiday gathering, or a simple weeknight family dinner, Lidia's flavorful, easy-to-follow recipes and advice will have you calling to your guests: "Tutti a tavola a mangiare!"
- Brand: KNOPF
Curious George and the Pizza Party with downloadable audio
Curious George and the Pizza Party with downloadable
George is going to a pizza party! George promises to be on his best monkey behavior, but when he gets to the party and sees all of that pizza dough, George has a big idea. With rolling pin in hand, George rolls and rolls and rolls until his big idea lands him in big trouble. But George's shaped pizzas turn out to be his biggest hits! This edition features a tasty veggie pizza recipe, put-the-steps-in-order activity, and downloadable audio!
- Brand: Curious George Paper
Pizza: Seasonal Recipes from Rome's Legendary Pizzarium
Pizza: Seasonal Recipes from Rome's Legendary
A fresh take on everyone's favorite food, straight from the "Michelangelo of dough" (Vogue). Yeast, flour, and water—from such humble ingredients rises a food that is for many an object of devotion. Here is a cookbook that reveals the secrets of the crust straight from the source in Italy. Gabriele Bonci, known throughout his country as the King of Pizza, operates a small pizzeria in Rome, where for the past ten years he has developed his signature style: making use of stone-milled farro flours, relying on the seasons to determine his unconventional topping combinations (he comes up with more than 1,500 each year), and inventing new techniques for sandwich pizza and fried pizza. The more than eighty recipes here (adapted for the American kitchen) will have pizza geeks' heads spinning: pizza with grilled peaches and chicory; potatoes, eggplant, and rosemary "ash"; asparagus, egg, and lemon; endive, olives, and anchovies. This is Roman-style pizza al taglio—rectangular with an airy, foccacia-like dough that can support an ample topping. Bonci details his process for making dough, including his own sourdough starter. Whether for the expert or novice baker, this book revolutionizes the concept of pizza and introduces flavor combinations that can apply throughout the kitchen.
- Brand: imusti
Big Green Egg Cookbook: Celebrating the Ultimate Cooking Experience
Big Green Egg Cookbook: Celebrating the Ultimate Cooking
The cookbook EGGheads have been waiting for that features over 160 recipes designed specifically for the ceramic kamado cooker, the Big Green Egg. It can sear, smoke, roast, and bake.The Big Green Egg Cookbook is the first cookbook specifically celebrating this versatile ceramic cooker. Available in five sizes, Big Green Egg ceramic cookers can sear, grill, smoke, roast, and bake. Here is the birthday gift EGGheads have been waiting for, offering a variety of cooking and baking recipes encompassing the cooker's capabilities as a grill, a smoker, and an oven.The book's introduction explains the ancient history of ceramic cookers and the loyal devotion of self-proclaimed EGGheads to these dynamic, original American-designed cookers. Complete with more than 160 recipes, 100 color photographs, and as many clever cooking tips, the Big Green Egg Cookbook is a must for the more than 1 million EGG owners in the United States and a great introduction for anyone wanting to crack the shell of EGGhead culture.
- Brand: Andrews McMeel Publishing
Pizza Party! (Hello Reader! Level 1)
Cook's Illustrated Revolutionary Recipes: Groundbreaking techniques. Compelling voices. One-of-a-kind recipes.
Cook's Illustrated Revolutionary Recipes: Groundbreaking techniques. Compelling voices.
2019 IACP Award Winner in the Compiliations CategoryOn the occasion of Cook's Illustrated's 25th anniversary, we've gathered together our most extraordinary recipes and innovations from the past quarter-century in this hands-on book packed with practical tips and techniques.These recipes tell the story of how Cook's Illustrated has changed American home cooking through its signature blend of rigorous testing, culinary research, science, and unorthodox approaches to developing foolproof recipes. As fans know, a big part of what makes the magazine so trustworthy (and enjoyable to read) is the essays that accompany each recipe, tracing from initial brainstorming to aha moments (and the occasional catastrophe) to final success. Rarely republished since they first appeared, these feature-length stories celebrate the art of food writing and the extensive work that goes into every recipe.In addition to the recipes, essays, and helpful sidebars, this book also features the trademark black-and-white illustrations that have become synonymous with Cook's Illustrated, creative use of the beloved front- and back-cover art, and a new addition: gorgeous, full-color photographs of each dish.Featured recipes include: Perfect corn on the cob that never gets boiled, ultracreamy tomato soup that's c...
Wood-Fired Oven Cookbook: 70 Recipes for Incredible Stone-Baked Pizzas and Breads, Roasts, Cakes and Desserts, All Specially Devised for the Outdoor Oven and Illustrated in Over 400 Photographs
Wood-Fired Oven Cookbook: 70 Recipes for Incredible Stone-Baked
Wood-fired ovens can be found around the world wherever there is access to wood, and although shape and building materials may vary the thing they have in common is how efficiently they produce and retain heat. It is easy to see why wood-fired ovens have survived, virtually unchanged, for centuries; once you've cooked in one you too will be converted to this elemental method of cooking with fire. The wood-fired oven is capable of cooking just about anything, but the amazing thing about it is how perfectly it cooks not only stone-baked pizzas and breads, but also sizzling meat, tender seafood, slow-cooked, smokey casseroles, and even beautifully moist cakes and desserts. This book covers every aspect of cooking in a wood-fired oven, with advice on where to site and construct your oven and instructions on how to season it, light your first fire, and control and maintain cooking heat. The recipes are all specially devised for the oven, and come with step-by-step instructions and photographs. A special chapter contains irresistible pizzas with innovative toppings such as artichoke hearts, Parma ham and basil pesto or caramelized shallot and feta. Once you have perfected your pizzas you will want to use your fired-up oven to cook amazing dishes like fish soup with aioli, jerk chicken,...
- Brand: Brand: Anness
The Healthy 5-Ingredient Air Fryer Cookbook: 70 Easy Recipes to Bake, Fry, or Roast Your Favorite Foods
The Healthy 5-Ingredient Air Fryer Cookbook: 70 Easy
Quick and Nutritious Meals and Snacks Made in Your Air Fryer! This exciting cookbook is an exploration of all that your air fryer can do for you. The authors have incorporated a myriad of world flavors with a generous selection of vegetarian and vegan options as well as more traditional comfort foods—all utilizing only a handful of ingredients. Recipes like Sriracha Shrimp will appeal to sophisticated palates, but there's also a whole chapter of healthy kid-friendly options! Find recipes such as: Blueberry French Toast MuffinsTeriyaki Chicken with Broccoli and CarrotsFlatbread Veggie PizzasPistachio-Crusted Shrimp with Asian Dipping SauceCrispy Cajun Sweet Potato WedgesGarlic-Parmesan ChickpeasChili-Lime Taro ChipsVeggie and Chickpea NuggetsGingered Almond Cookies With the air fryer as your new go-to appliance, you too can discover fresh and easy ways to elevate your meals, whether you're new to cooking or just new to air fryers.
150 Best Toaster Oven Recipes
150 Best Toaster Oven
A collection of recipes that is as versatile as your toaster oven itself. Toaster ovens are versatile, compact and convenient, doing the job of both a toaster and a full-size oven while using far less space and far less energy. They can do so much more than just toast -- they can bake, broil, brown and keep food warm. This updated edition includes 125 delicious recipes from Linda's previous book, practical tips, and information on various toaster ovens, and, by popular demand, an all-new "Basics" section with over 25 easy recipes. All of the recipes are designed exclusively for toaster ovens and include delicious options for any time of day. Some of the new basics include Deli Tuna Melts, BBQ Meatballs, Vegetable Bean Chili, and Chocolate Chip Muffins. Still featured are old favorites like Salmon Satays and Stuffed Baked Potatoes. With easy-to-prepare recipes and clear instructions, 150 Best Toaster Oven Recipes is perfect for students, singles and anyone looking to make a delicious meal in their toaster oven.
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What's Gaby Cooking: Everyday California Food
What's Gaby Cooking: Everyday California
In What's Gaby Cooking Everyday California, Gaby Dalkin shares more than 125 of her favorite simple and fresh recipes and offers a glimpse into what it's like to "go coastal." It's about always having something tasty to eat, thanks to handy and delicious pantry staples (avocado oil! quinoa! limes! dark chocolate!), as well as an arsenal of easy and healthy recipes, like Chimichurri Cauliflower Rice Bowl with Grilled Fish, Taco Skillet Bake, and Street Corn Pizza. The book covers all the staples—avocado toast, grain bowls, greens, carbs, healthy mains, cocktails, and more. For Gaby, California is not so much a place but a state of mind, and this cookbook proves that no matter where you live, you can still apply the same philosophy. All it takes is finding the freshest produce you can, stocking up on some versatile pantry staples, and keeping flavors and techniques simple. After that, the only thing left to do is kick back, pour yourself a California Girl Margarita, and listen for those ocean waves.
Blackstone Signature Griddle Accessories, Restaurant Grade, 2 Spatulas, 1 Chopper Scraper, 2 Bottles, FREE Recipe Book, 5 Piece Tool Kit for BBQ Grill, great for Flat Top Cooking, Camping and Tailgating
Blackstone Signature Griddle Accessories, Restaurant Grade, 2 Spatulas,
The Blackstone Griddle Kit offers 2 Liquid Dispensers, 2 Professional Grade Spatulas, 1 Chopper Scrapper and a Blackstone Introductory Griddle Cook Book. Step up your backyard cooking game and add the tools needed to make it the most enjoyable experience possible. This kit has everything you need to get going. Use the included cook book for inspiration or new recipes .
- Color: Original Version
- Brand: Blackstone
The Newlywed Cookbook: Fresh Ideas and Modern Recipes for Cooking With and for Each Other
The Newlywed Cookbook: Fresh Ideas and Modern Recipes
This cookbook is an indispensable reference for modern couples looking to spend quality time together in the kitchen. Inside are more than 130 recipes for both classic and contemporary cooking that are perfect for day-to-day deux and special occasions with family and friends. More than a collection of recipes, The Newlywed Cookbook is also a guide to domestic bliss. Author Sarah Copeland, a newlywed herself, knows that sourcing, cooking as well as sharing food together at the table makes for a happy couple! This beautiful and sophisticated contemporary cookbook is the new go-to for brides and grooms.
- Brand: Chronicle Books
The Essential Wood Fired Pizza Cookbook: Recipes and Techniques From My Wood Fired Oven
The Essential Wood Fired Pizza Cookbook: Recipes and
I have always had a passion for fire and wood ovens. Anthony's own love for cooking with fire is contagious and his knowledge about wood-fired pizza is all encompassing. This is an inspiring and well-written book from a teacher you can really trust!—Alice Waters, author of The Art of Simple Food and Owner of Chez Panisse Restaurant From Anthony Tassinello, chef at Berkeley's famed Chez Panisse, your must-have pizza cookbook for making mouth-watering meals from your wood-fired pizza oven—from classically simple Margherita pizza to more exciting and challenging recipes. From those first drawn-out moments when the blistering dough rises against the oven floor to that steamy first bite, chef Anthony Tassinello walks you through the time-tested tradition of preparing—and savoring—a perfect wood-fired oven pizza. Tassinello shares need-to-know tips and techniques for crafting palate-pleasing pizzas, calzones, hand pies, focaccia, and more, while reminding us all of the joy of gathering friends and family over a mouth-watering home-cooked meal. With over 85 recipes ranging from fresh takes on classic pizzas to inspired new combinations, plus a bonus "beyond pizza" chapter that showcases the versatility of wood-fired cooking, this is the go-to wood-fired pizza oven resource...
Pizza Party
Sharon O'Connor brings you everything you need for a pizza party - easy recipes for pizza dough, sauce, and toppings Charlie Giordano's Pizza Band plays Neapolitan songs that carry you away to Naples - where the singature dish is pizza! Includes practical cook's tips for making authentic pizzas in your home kitchen.
- Brand: MusicCooks
The Recipe: Classic dishes for the home cook from the world's best chefs
The Recipe: Classic dishes for the home cook
Michelin-starred chef Josh Emett brings together more than 300 of the most important classic recipes by 150 of the world's most acclaimed chefs. Taken together, this is a compendium of the crème de la crème of blue ribbon cooking from the world's top restaurants in an elegantly designed volume that will stand up to use in the kitchen but be classically beautiful to behold - sure to delight any food lover or serious home cook.Josh Emett, holder of three Michelin stars and best known for opening Gordon Ramsay's restaurant at the London Hotel in New York, has collected the most important classic recipes from the world's most acclaimed chefs to create a kind of Larousse Gastronomique of the 21st century. These are the best new classics that have emerged during the last 50 years from culinary stars.Each recipe has been tested by Emett in his home kitchen, and he includes guidance and advice for the home cook-- discussing complexity, preparation, key elements, complements for planning a larger menu, and tips of the trade.Featuring specially commissioned photographs, the book is organized into 12 easy-to-follow sections from basics (stocks, sauces, and dressings), to grains and vegetables, meats, seafood, baking, and more. Each section includes a dedicated introduction with key knowle...
PINAFORE Indoor/Outdoor Spillproof Tablecloth Pizza Recipe Wedding Restaurant Party Decoration W25.5 x L65 INCH (Elastic Edge)
PINAFORE Indoor/Outdoor Spillproof Tablecloth Pizza Recipe Wedding Restaurant
This is a retro and elegant tablecloth, making your dining table unique. Gorgeous patterns, relaxed dining atmosphere, it is worthy for you. Features: Made from Polyester fiber print. Stylish, avant-garde pattern. Create a classic tablecloth. soft, pattern and fabric perfect fusion, never fade. Elastic Edge ,Anti-wrinkle, machine wash, mild circulation, the trunk will not shrink. With this decorative tablecloth, you can easily dress up your table and help your family and friends enjoy any occasion at home, party, hotel, restaurant and coffee shop. home decoration wallpaper quality, flower design avant-garde. Fabric feel soft. Use more. Really beautify your vision and make you feel happy. Due toputer/screen display, the color of the actual item may slightly from the above images. As a result of manual production, sewing and cutting will inevitably occur a little deviation, please allow 2cm. Hand-washing and machine washing are all available,but we suggest hand-washing and not dewatering, you can medium temperature ironing. Avoid prolonged exposure to the sun. Quality guarantee: Quality is a top priority at art of beauty. If there's any reason you're not 100% SATISFIED, let us know and you will getfriendly customer service.
- Color: Color08
- Brand: PINAFORE
Camp Chef Artisan Pizza Oven 90
Camp Chef Artisan Pizza Oven
Camp Chef: The Way to Cook Outdoors The Camp Chef Artisan Pizza Oven 90 accessory cooks the perfect pizza every time. Designed after the idea of a true, wood fire pizza oven, the Italia Pizza Oven takes your homemade pizza to the next level. A ceramic pizza stone promotes even heat and will give your pizza a delectable crust. Enjoy hot, fresh, flavorful pizzas cooked on your patio, in camp or where ever you take your Camp Chef stove. Great to cook breads, cookies, and pies too. Features - Opened face pizza oven cooks like a traditional wood-fired brick oven - Fully adjustable heat allows for cooking several styles of pizza including artisan, premade, and frozen pizzas. - Ceramic stone pulls outer moisture off dough and promotes perfect crust, leaving the inside moist and fluffy. - Pizza stone made of cordierite ceramic - Specially designed heat diffusion plates - Built in temperature gauge - Includes Italia Pizza Oven Cooking Guide with recipes - Fits all Camp Chef 16" Cooking System stoves - Temperature range: Temperatures can reach up to 700° F Specifications - Cooking Surface Diameter: 15" x 20" (300 sq. in) - Overall Dimensions: 16" x 24" x 9" - Front Opening Dimensions: 20.5 x 4.5 - Product Weight: 30 lbs. *Do not heat on high on a Camp Chef stove
- Brand: Camp Chef
The Hungover Cookbook
The Hungover
Everything you need to know to assess, understand, and improve a hangover is here: dozens of comforting recipes, very clever graphic tests for analyzing your state of mind, and quizzes for tracking your progress. A good hangover brings its victim to a new state of mind—and one that, when looked at objectively, can be quite fascinating to its host: It can create an increased awareness of the body, a willingness to eat something usually off limits, and a fascination with the mind's strange acrobatics. With P. G. Wodehouse's six hangovers—The Broken Compass, The Sewing Machine, The Comet, The Atomic, The Cement Mixer, and The Gremlin Boogie—as a starting point, recipes are tailored to each specific malady, allowing the reader to find a recipe (or just a menu item) that precisely suits his state of mind . . . and body. Interspersed with the recipes are mind games, witticisms and graphic jokes, insights into hangover science, quizzes to see if you are still drunk or now just merely hungover, and more.
- Brand: Clarkson Potter Publishers
9 Mind-Blowing Food Party Rings
Reserve the One Top: http://bit.ly/2v0iast Get the recipes: http://bzfd.it/2ykYqCT Check us out on Facebook! - facebook.com/buzzfeedtasty Credits: https://www.buzzfeed.com/bfmp/videos/35819 MUSIC Licensed via Audio Network
8 Game-Changing Pizza Recipes
Get the recipes here: http://bzfd.it/2r0lek2 Check us out on Facebook! - facebook.com/buzzfeedtasty Credits: https://www.buzzfeed.com/bfmp/videos/16827 MUSIC Pista Licensed via Warner Chappell Production Music Inc.
"No Dough" Make Your Own Pizza Party! | One Pot Chef
Since my surgery a few years ago, I haven't been able to eat traditional pizza dough due to digestion problems. I tried so many alternatives over the years, but this is the only one that is quick, easy gives a great pizza taste. Plus it's perfect for a fun Make Your Own Pizza bar at your next kid...


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Russian Prince Vodka
Item # 53546 | UPC 620213100511 | 1.14 Litre
Russian Prince is a high quality domestic vodka characterized by its lightweight, unbreakable bottle and unbeatable value. The name Russian Prince, honors the legacy of Russia's vodka heritage. Tasting Note: Russian Prince is triple distilled and triple filtered for purity, clarity, and smoothness.
Producer LinksBacardi Canada Inc
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|MRI in diagnosing different types of morbidly adherent placenta
|Poster No.:
|Educational Exhibit
|Obstetrics (Pregnancy / birth / postnatal period), Genital / Reproductive system female, Pelvis, MR, Diagnostic procedure, Obstetrics
|U. S. Umer, S. Alam, A. N. Khan, S. G. Ghaus, S. Gul, S. Gul, H. Abid, A. Safi, K. Nawab; Peshawar/PK
Introduction and Pathophysiology:
Morbidly adherent placenta (MAP) is a severe pregnancy complication that occurs when the chorionic villi abnormally invade the myometrium. Its pathogenesis is primarily attributed to defective decidualization of the implantation site. The increasing incidence of morbidly adherent placenta has greatly increased the risk of a possible threat to life1, 2. The incidence of MAP has risen substantially due to the increased rate of cesarean sections (CS) 3 and previous damage to myometrial wall, through prior cesarean section is the most important risk factor.
Morbidly adherent placenta remains one of the greatest challenges in modern obstetrics 9. Clinical risk factors include placenta previa and prior uterine surgery, including CS delivery. Current estimates indicate a 25% to 50% incidence of placenta accreta in patients with placenta previa and prior cesarean delivery.
Types of Morbidly Adherent Placenta:
It has three variants depending on the depth of placental invasion (Figure.1):
- Accreta: The placenta is attached to the myometrium.
- Increta: The placenta extends into the myometrium.
- Percreta: The placenta extends through the entire myometrium and uterine serosa; this variant can lead to the placental attachment to other organs such as the rectum and bladder.
Fig. 1: Diagram of grades of abnormal placental infiltration. (1) Placenta accreta is adherent to the myometrium. (2) Placenta increta invades the myometrium. (3) Placenta percreta extends into or beyond the uterine serosa and may invade any other organ.
References: Radiology Department, Rehman Medical Institute, Rehman Medical Institute - Peshawar/PK
Early and systematic detection of abnormal placentation is a crucial step in planning delivery and subsequent management. Optimal management requires accurate prenatal diagnosis.
Role Of Imaging:
Ultrasonography (USG) and magnetic resonance imaging (MRI) are the modalities for prenatal diagnosis of placenta accreta, although USG is primary investigation of choice and MRI is used as complementary technique usually reserved for further characterization when USG is inconclusive or incomplete 2. Reader accuracy and confidence require adherence to MRI examination performance, image interpretation criteria and awareness of common pitfalls4.
Different MRI techniques and sequences have been studied for accurate detection of morbidly adherent placenta. This exhibit focuses on the different variants of MAP, its association with previa and specific imaging findings on MRI. We would identify new criteria and review established MR criteria for diagnosis of MAP and its correlation with clinical outcome. The aim of this poster is to provide a primer for radiologists performing MRI for suspected morbidly adherent placenta, illustrating normal and abnormal findings and diagnostic pitfalls.
Thematically related posters
Prenatal planning of placenta previa: diagnostic accuracy of a MRI-based model for the placental invasion and clinical outcome prediction


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About the host
Noluyolo joined Allan Gray in 2015, and is currently a Client Relationship Manager in the Strategic Markets team, having previously worked in client and adviser services within the retail business. She holds a Bachelor of Commerce degree and an Honours in Economics from Rhodes University.
About the presenters
Nomi joined Allan Gray in 2015 and is currently the head of Strategic Markets. She previously held managerial roles in the Retail Client Service department. She holds a Bachelor of Engineering degree from the University of Cape Town and a Master of Philosophy degree in Engineering for Sustainable Development from Cambridge University.
Mthobisi joined Allan Gray in 2011. He is currently the manager of the Private Client team. He previously worked in Operations, Client Services and Strategic Markets within the Retail business. He holds a Bachelor of Commerce degree from Rhodes University and a Postgraduate Diploma in Financial Planning from the University of Free State. Mthobisi is a CFP® professional.
What is a webinar?
A webinar is a live online event. You will be able to listen to our presenters, view their presentation and ask questions in real-time through an instant messaging tool (if the webcast allows for this).
Allan Gray is an authorised financial services provider.


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Our re-conditioning facility has the experienced employees and tools with functionality of turning old soiled emu furniture furniture into fully refurbished emu furniture furniture. In case you are just opening up and on a tight budget, consider our used and refurbished restaurant furniture. We are able to accommodate any client with a total package deal or particular person pieces from concept to drawings to grand opening. You've got made an enormous step and we're right here that will help you in the final stage of opening what you are promoting. Their sophisticated and upscale designs catch attention immediately and help visitors loosen up and get pleasure from their expertise in your bar, restaurant or nightclub. Here at Holders Restaurant Furniture we concentrate on your design and constructing customized restaurant furniture since 1990. Your desires and needs are given prime priority and attention.
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What did you think of today's match at Lansdowne Road between Ireland and Wales?
What were the main talking points? How is it looking for each team in this year's tournament?
Let us know what you thought here.
What did you think of today's match at Lansdowne Road between Ireland and Wales?
What were the main talking points? How is it looking for each team in this year's tournament?
Let us know what you thought here.
Good one Tim.
Wales were abysmal. Ireland dominating and only when they eased off did Wales manage to create anything.
Wales finally found out for the mediocre team they are.
Jeeze Jake! It was 1 game. It too was mostly an arm wrestle until Ireland got away. Don't know what evidence there was about Ireland easing off either. Perception maybe? Do you think England in comparison were world beaters after their ltd grind & kick policy?
Disagree Don
Think Ireland showed more intent and were better going forward. They led most of the attacking stats.
Wales came alive in the second half but didn't show much.
Nothing to do with England do, maybe just your perceived bias?
Yr criticism of Wales seemed unduly harsh & to write them off after this 1 game. No skin off mine, but Ireland were at home & looked fairly ordinary v Scotland. Disallowed try might have made a difference. This coming from, presumably an Englishman, seemed a bit rich after England's 1 try grindathon & 47 kicks! Regds stats BTW, the Jocks had more poss, territory v England, but couldn't make them count, so these can be misleading.
IMO Wales trump card of being a hard to beat side has now become their achilles heel. They seem to play a game of absorbing all the pressure and then hanging on in there trying to break the will of their opponent. It worked for a while, but I feel this also let them down in the WC with a narrow (gifted) win against France and a blunt performance against SA in the semis. Ireland didn't do anything amazing yesterday, they just played what was in front of them and opened up light on the scoreboard that Wales could not claw back. Wales looked short of energy in the second half.


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Why Use Kirvin & Small – There's no doubt about it. Your real estate agent has a huge impact on whether or not your home sells quickly, how much you get for your property, and your experience throughout the process.
So you'd be smart to ask, "Why should I sell with Kirvin & Small?"
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To learn more about Kirvin & Small and how we work click on the other links under the For Sellers tab.


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Subsection 231(1) - Bad Debt — Deduction From Net Tax
North Shore Power Group Inc. v. Canada, 2018 FCA 9
A supplier (Menova) received substantial down payments respecting its sale of solar array projects, and then became insolvent before earning more than a fraction of the down payments. Menova then issued credit memos to the business customer (North Shore) for the value of the unperformed work, and was petitioned into bankruptcy before refunding any amount shown on the credit memos. Before going on to find that North Shore was not required to add the HST, which had thus been purportedly "credited" to it, to its net tax, Woods JA stated (at para. 41):
By subsections 225(1) and 228(2) of the Act, tax collectible must be remitted by a supplier if it is collectible, even if it is never collected. However, relief is provided to the supplier in subsection 231(1) if the amount collectible becomes a bad debt. There is no such relief provided for credit in section 232 which becomes a bad debt.
|Locations of other summaries
|Tax Topics - Excise Tax Act - Section 232 - Subsection 232(2)
|no sum is credited to the purchaser if no sum is placed at its disposal
See Also
North Shore Power Group Inc. v. The Queen, 2017 TCC 1, rev'd 2018 FCA 9
The appellant (North Shore) paid half (or approximately $3.0 million plus HST) of the purchase price for various solar array projects to the supplier ("Menova"). Menova only completed approximately 1/5 of the work, and issued "Credit Memos" (including HST) to North Shore late 2010 and in 2011 to reflect the work for which it had been paid but had not performed. North Shore made additions to its net tax under s. 232(3)(c) to reflect the HST in these credit memos. However, Menova was insolvent and was petitioned by North Shore into bankruptcy on June 29, 2012. North Shore sought to effectively reverse the s. 232(3)(c) additions to its net tax by claiming bad credits under s. 231. CRA's ultimate position was that the s. 232(3)(c) additions and s. 231 credits were valid and invalid, respectively. North Shore ultimately accepted that the s. 231 credits claimed were invalid. In accepting this concession (and before going on to accept the CRA position), Bocock J stated (at para. 26):
North Shore was neither a "supplier" nor did it make a "taxable supply". Factually, North Shore was a recipient who received a taxable supply.
|Locations of other summaries
|Tax Topics - Excise Tax Act - Section 232 - Subsection 232(3)
|HST imposed on a customer through the issuance to it of a credit note by an insolvent supplier
|Tax Topics - Excise Tax Act - Section 168 - Subsection 168(9)
|"deposit" for work being performed was not a deposit
Vivaconcept International Inc. v. The Queen, 2013 TCC 336
The appellant, a registrant in the events management business, invoiced a customer (Flora) for a total of $1,769,694 including GST of $103,440 for services rendered (and invoiced, see para. 22) over a 12-month period ending on October 2006, but was unable to collect anything as Flora was determined to be insolvent in November 2006. Flora made a settlement offer to its creditors in February 2007, which the appellant accepted, but no payments were made thereunder.
After Revenue Quebec indicated (at the end of 2008) that it would deny the appellant's claim (made for its quarterly reporting period ending on 31 January 2007) under s. 231 on the basis that the situation instead had called for a claim under s. 232 (apparently based on viewing the February 2007 agreement as an adjustment to the consideration), the appellant (in January 2009) entered into a write-off agreement with Flora, issued a credit note to Flora, and claimed a credit under s. 232(3) for the GST of $103,440 in its return for the reporting period ending on 31 January 2009. Revenue Quebec considered that the credit note had not been issued "within a reasonable time," as required by s. 232(3).
After stating (at para. 19) (TaxInterpretations translation) that the jurisprudence indicated "that the creditor need not have taken proactive measures if it reasonably and sincerely believed that recovery was impossible," Tardif J concluded (at para. 30) that in light of Flora's known insolvency, it was appropriate at the effective time of the bad debt claim to consider the debt to be irrecoverable and that any expense or effort to recover it would have been "a pure waste of energy and money." Respecting the "write-off" branch of s. 231(1), he stated (at para. 39) that "a contemporaneous document recording the decision to write-off the debt appears essential to the application of section 231," and (at para. 40) that here, the preponderance of evidence indicated the satisfaction of the write-off requirement.
The disposition of the "reasonable delay" issue is summarized below under s. 232(3). The appeal was allowed.
|Locations of other summaries
|Tax Topics - Excise Tax Act - Section 232 - Subsection 232(3)
|23 month delay acceptable
Ministic Air Ltd. v. The Queen, 2008 TCC 296
The appellant was not entitled to a credit under s. 231(1) in respect of the GST of approximately $170,000 owing to it as there was "little evidence as to the actual measures taken by the appellant to collect any specific debt" (para. 12), there was no evidence of the debt having been written off in the reporting period in question (although, at para. 14, the finding in Burkman v. The Queen, [1997] G.S.T.C. 98, "that a written note, as opposed to a journal entry, could satisfy the requirement that the debt must be written off in the books of account, in circumstances where no ledger existed" was accepted.) Furthermore, 1/3 of the appellant's receivable was owing by the holder "Garden Hill") of 98% of its shares. In this regard, Bowie J rejected the appellant's submission (at para. 20) that the provisions of ITA s. 251(2) (adopted for ETA purposes by ETA s. 126(2)) "simply raise a rebuttable presumption that the appellant and Garden Hill did not deal at arm's length, and that this presumption is rebutted by the evidence that the appellant's policy was to provide service to Garden Hill and its members at the same commercial rates that it charged to all its other customers."
|Locations of other summaries
|Tax Topics - Income Tax Act - Section 251 - Subsection 251(2) - Paragraph 251(2)(b) - Subparagraph 251(2)(b)(i)
McCool v. The Queen, 2005 TCC 357 (Informal Procedure)
In finding that the appellant, a criminal lawyer, had not satisfied the "writing off" requirements of s. 231(1) in respect of amounts owing to him by the Ontario Legal Aid Plan, Bonner J stated (at para 6):
[A] bad debt cannot be considered to have been written off in a person's books of account unless and until a notation is made in those books that the particular debt has been written off. …A journal entry ought to be made to clear out each worthless receivable. Otherwise, subsection 231(3) would be impossible to enforce.
Administrative Policy
P-084R "Forgiven Debts Considered Bad Debts" 8 March 1999
[F]orgiven debts pursuant to an arrangement under the Companies' Creditors Arrangement Act are considered to be bad debts as opposed to reductions of consideration. As such, the provisions of section 231 of the ETA apply to forgiven debts as opposed to the provisions of section 232 of the ETA.
|Locations of other summaries
|Tax Topics - Excise Tax Act - Section 232 - Subsection 232(2)
B-042 "Refund, Adjustment or Credit of GST"
Policy Statement P-029R "Bad Debts Reduction when Accounts Receivable are Bought or Taken Back"
GST Policy Statement P-029, dated September 4, 1992 "Assignment of Accounts Receivable"
A registrant is entitled to claim a deduction pursuant to the provisions of subsection 231(1) of the Act in situations where the receivable has been transferred, such as by way of assignment, and the registrant has been required to buy or take back the receivable, provided the other requirements of the subsections have been met (i.e., the registrant had charged, collected, remitted and accounted for the GST on the sale and subsequently found that it could not collect i.e., bad debt)."
Sabrina Wong, Sania Ilahi, "Tax Implications of Asset Securitizations", 2015 CTF Annual Conference Report
Advantages of sale to securitization trust on recourse basis (p. 12:25)
P-029R [states]:
...It is the Department's position that where a person agrees to buy or take back a receivable, in whole or in part, that was previously transferred to a third party, the person may claim a deduction under subsection 231(1) of the Excise Tax Act provided the conditions have been met.
...It is therefore advisable to sell trade receivables on a recourse basis, which allows any bad debts to be transferred back to the original supplier to claim the bad debt adjustment. However, this condition may be at odds with the accounting provisions that limit the recourse by an SPE to the assignor... .
Steven D'Arcy, "Tax Paid in Error", Canadian GST Monitor, No. 136, 31 January 2000, p. 1.
Subsection 232(1.1)
Administrative Policy
18 September 2017 Interpretation 176502
A registrant is reassessed for GST/HST that it did not charge on an invoice to a customer which declared bankruptcy prior to the reassessment and is unable to pay the invoice. Can the GST/HST amount assessed under s. 296(1)(d) satisfy the requirements for a credit under s. 231(1), given the reporting requirement under s. 231(1.1)? CRA responded:
[T]he supplier would not be in a position to claim a deduction under subsection 231(1.1) if it only learned the amount of the tax after an audit, since it could not have already reported it on its return nor paid the amount of tax owed.
However, section 232 does appear to offer a solution where the consideration is reduced. Where the supplier issues a credit note to the customer (which is now bankrupt) to relieve it of that debt, the supplier would be entitled to claim a deduction if all conditions set out in paragraph 232(3)(b) are met.
|Locations of other summaries
|Tax Topics - Excise Tax Act - Section 232 - Subsection 232(2)
|credit can be generated by issuing credit note to bankrupt customer


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Events for February 25, 2020
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Complete Credit & Credit Repair Guide
Credit scores can have a significant impact on your consumer?s financial life. Lenders rely on scores extensively in decision making, including the initial decisions of whether to lend and what loan terms to offer, for most types of credit, including mortgages. This program provides the Realtor with a deeper understanding of Credit, Credit Scores and the effect on their clients. Continue ReadingFind out more »


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Heartland Community College will formally open a new, expanded Lincoln Center on Thursday, May 31 with a ribbon cutting ceremony at 3:30 p.m at 2201 Woodlawn, Rd. in Lincoln.
The ribbon cutting ceremony will be followed by an Open House for the public to tour the 5,830 square foot facility until 6 p.m.
Heartland leadership is enthusiastic about the investment in the new facility and are looking toward the dividends an expanded Lincoln Center will provide for Logan County.
Heartland President Rob Widmer, Associate Director of Lincoln Center Kristi Powell and local officials will be on hand to give tours of the new space.
"This is an exciting step in our efforts to serve the needs in the southern part of our district," said Heartland President Rob Widmer.
"By expanding programs focused on specific student and community needs, we're likely to see increased enrollment, greater student completion and generally enhanced engagement with Lincoln and Logan County constituents."
Kristi Powell, associate director of the Heartland Lincoln Center, said the move was based on the needs of the community.
"We've met and talked with a lot of community leaders and organizations in the area," said Powell. "With the expansion of St. Clara's Manor and an aging population, there is a high demand for CNAs. Plus, several businesses in Logan County are ag-based. As a community resource, we need to ensure we're meeting employer needs."
The new facility will replace the current location in downtown Lincoln and will allow the College to grow programing that includes certified nursing assistant (CNA), agriculture, continuing education and adult education.
Music, food, children's activities will round out the opening celebration.


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My sleep schedule is all out of whack these days. We were up late last night, playing games and enjoying friends at R&S's, and I completely fell asleep on the drive home. Then after less than 4 hours sleep, I was up at 5:30. Poked around on the computer for about half an hour, went back to sleep for a couple of hours, then was up again. Then I fell asleep in the car again on the way down south for a birthday party, was a bit draggy throughout the event, almost conked out yet again on the drive home, then slipped into an hour nap.
It would be one thing if this were a one-time event, but it's gotten to be typical -- I wake up early almost every morning, sometimes go back to sleep for an hour or two and sometimes don't, and end up tired all day. Functioning on six hours sleep or less is pretty much normal for me now; I suppose I'm getting used to it, but I probably ought not to. I've tried going to bed earlier, but I just wake up earlier. Plus T is such a night person, and I hate to give up the extra hour or so with him each night. I used to be a night person, too; what happened?


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2020 Lexus LF-LC
2020 Lexus LF-LC Considering the L is special order only, and the LS would not add much for a substantial worth bump, we predict it is worth skipping straight to the LT model. Its listing of added features is not extensive, however you do get upgraded headlights for better nighttime visibility, together with satellite tv for pc radio and tinted glass. The LT also opens the doorways to a number of worthy option packages. The Confidence and Comfort package stands out, with further luxury options and blind-spot monitoring.
Fortune does not necessarily favor the bold within the compact crossover phase — the Honda CR-V, the Nissan Rogue and the Toyota RAV4 are perennial best-sellers thanks partly to their all-around competencies and history of reliability. Still, automakers attempt to make their small SUVs distinct. The 2020 Lexus LF-LC stands out by bringing high-end luxury features and a few distinctive engines to this usually price-conscious class.
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We additionally like that the 2020 Lexus LF-LC offers two various powertrains when you aren't satisfied with the bottom turbocharged 1.5-liter engine. At one finish of the spectrum is a fuel-efficient diesel that achieves 32 mpg in mixed driving (the usual engine earns 28 mpg); on the different, a turbocharged 2.0-liter with a further 80 horsepower. Watch out, nonetheless: Once you start checking the choices packing containers, the 2020 Lexus LF-LC could be considerably costlier than rival crossovers. An engine stop-start system that can't be disabled and disappointing supplies high quality also may give potential patrons pause.
2020 Lexus LF-LC fashions
The 2020 Lexus LF-LC is a five-passenger compact crossover that prices a bit more than most rivals. It's offered in four trims: L, LS, LT and Premier. The bottom L mannequin looks as if an ideal deal until you understand that it's a custom-order model and you will have to attend for it to be constructed. You'll discover the LS at virtually any dealer, nevertheless it's more expensive and would not add much. Finest to skip straight to the LT, which is just a bit more expensive and includes more options and access to extra choices. In order for you the LT and its two packages, the leather-trimmed Premier consists of it all.
Three engines are provided on the 2020 Lexus LF-LC. The standard engine is a turbocharged 1.5-liter four-cylinder (170 horsepower, 203 pound-feet of torque) matched to a six-speed computerized transmission. A extra powerful turbocharged 2.0-liter engine (252 hp, 260 lb-ft) is optional and comes commonplace with a nine-speed computerized transmission. Additionally optional is a fuel-efficient 1.6-liter diesel (137 hp, 240 lb-ft) mated to a six-speed automated. Each of those engines will be ordered on LT and Premier trim levels.
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