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The immune response Anca Bacârea, Alexandru Schiopu The importance of immune system The immune system is clearly essential for survival. It constantly defends the body against bacteria, viruses, and other foreign substances it encounters. It also detects and responds to abnormal cells and molecules that periodically develop in the body so that diseases such as cancers do not occur. An essential aspect of the immune response is the ability to recognize almost limitless numbers of foreign cells and nonself substances, distinguishing them from self molecules that are native to the body – it distinguishes self from nonself. Definitions The immune system consists of the central and peripheral lymphoid tissues. The individual components of the substance that the immune system recognizes as foreign are called antigens. The interaction of the collective and coordinated components of the immune system and the antigens of a foreign agent is called the immune response. The immune system The central lymphoid organs the bone marrow and the thymus provide the environment for immune cell production and maturation The peripheral lymphoid organs Lymph nodes, spleen, tonsils, appendix, Peyer's patches in the intestine, and mucosaassociated lymphoid tissues in the respiratory, gastrointestinal, and reproductive systems function to trap and process antigen and promote its interaction with mature immune cells The immune system - classification The immune system Nonspecific or innate defense system Cellular Humoral Specific or acquired immune system Cellular Humoral Nonspecific or innate defense system First line of defense system It distinguishes self from non-self but does not distinguish one type of pathogen from another. Components: skin and mucous membranes inflammatory response phagocytic and non phagocytic leukocytes cells Nonspecific defense system 1. Mechanical factors The epithelial surfaces form a physical barrier that is very impermeable to most infectious agents. The skin acts as our first line of defense against invading organisms. The desquamation of skin epithelium also helps remove bacteria and other infectious agents that have adhered to the epithelial surfaces. Movement due to cilia or peristalsis helps to keep air passages and the gastrointestinal tract free from microorganisms. The flushing action of tears and saliva helps prevent infection of the eyes and mouth. The trapping effect of mucus that lines the respiratory and gastrointestinal tract helps protect the lungs and digestive systems from infection. Nonspecific defense system 2. Chemical factors Fatty acids in sweat inhibit the growth of bacteria. Lysozyme and phospholipase found in tears, saliva and nasal secretions can breakdown the cell wall of bacteria and destabilize bacterial membranes. The low pH of sweat and gastric secretions prevents growth of bacteria. Defensins (low molecular weight proteins) found in the lung and gastrointestinal tract have antimicrobial activity. Surfactants in the lung act as opsonins (substances that promote phagocytosis of particles by phagocytic cells). 3. Biological factors The normal flora of the skin and in the gastrointestinal tract can prevent the colonization of pathogenic bacteria by secreting toxic substances or by competing with pathogenic bacteria for nutrients or attachment to cell surfaces. Nonspecific defense system The anatomical barriers are very effective in preventing colonization of tissues by microorganisms. However, when there is damage to tissues the anatomical barriers are breached and infection may occur. Once infectious agents have penetrated tissues, another innate defense mechanism comes into play, namely acute inflammation. Humoral factors play an important role in inflammation, which is characterized by edema and the recruitment of phagocytic cells. Nonspecific humoral immune system The complement system The complement system is a primary mediator of the humoral immune response that enables the body to produce an inflammatory response, lyse foreign cells, and increase phagocytosis. The complement system, like the blood coagulation system, consists of a group of proteins that normally are present in the circulation as functionally inactive precursors. These proteins make up 10% to 15% of the plasma protein fraction. For a complement reaction to occur, the complement components must be activated in the proper sequence. Uncontrolled activation of the complement system is prevented by inhibitor proteins. Complement activation The classic pathway of complement activation is initiated by antibody bound to antigens on the surface of microbes or through soluble immune complexes. The alternate and the lectin pathways do not use antibodies and are part of the innate immune defenses. The alternate pathway of complement activation is initiated by the interaction with certain polysaccharide molecules characteristic of bacterial surfaces. The lectin-mediated pathway is initiated following the binding of a mannose-binding protein to mannose-containing molecules commonly present on the surface of bacteria and yeast. The activation of the three pathways produces similar effects on C3 and subsequent complement proteins. Complement activation Immune Cells Nonspecific immune cells Phagocytes: Neutrophyles – bacteria Eosinophyles – enzymes that kills parasites Macrophages - "big eaters" Non phagocytic leukocytes: Basophiles – role in allergic response Mastocytes Natural killer lymphocytes – antiviral and anti-tumor activity Nonspecific immune cells Macrophages have important functions in both innate and antigenspecific immune responses. As phagocytic cells with antigen nonspecific activity, they help to contain infectious agents until specific immunity can be marshaled. In addition, early in the host response, the macrophage functions as an accessory cell to ensure amplification of the inflammatory response and initiation of specific immunity. Macrophages are activated by the presence of antigen to engulf and digest foreign particles. Activated macrophages act as antigen presenting cells (APCs) that break down complex antigens into peptide fragments that can associate with class I or II Major Histocompatibility Complex (MHC) molecules. Macrophages can then present these complexes to the helper T cell so that nonself-self recognition and activation of the immune response can occur. Presentation of antigen to helper T cell by an antigen-presenting cell (APC) NK cells The NK cell is a nonspecific effector cell that can kill tumor cells and virus-infected cells. They are called natural killer cells because, unlike T cytotoxic cells, they do not need to recognize a specific antigen before being activated. NK cells kill after contact with a target cell. The NK cell is programmed automatically to kill foreign cells. Programmed killing is inhibited if the NK cell membrane molecules contact MHC self-molecules on normal host cells. The mechanism of NK cytotoxicity depends on production of poreforming proteins (i.e., NK perforins), enzymes, and toxic cytokines. Specific Immunity Specific or acquired immunity develops during an individual's lifetime. It distinguishes self from nonself, and responds specifically to different pathogens and foreign molecules. Components: Lymphocytes are key players in the specific or acquired immune response: Lymphocytes represent 20% to 40% of blood leukocytes; T lymphocytes (also called T cells), which participate in cell-mediated immunity (60-70%); B lymphocytes (also called B cells), which participate in humoral immunity (10-20%); Cell-mediated immunity involves the production of cytotoxic T cells, which have the ability to destroy antigen-bearing cells. Humoral immunity is characterized by the transformation of B cells into plasma cells, which secrete immunoglobulins (antibodies) that have specific activity against the inciting antigen. T cells T cells are maturated in the thymus. There, they learn how to distinguish self from nonself. Only the T cells that ignore self antigen molecules are allowed to mature and leave the thymus. Without this training process, T cells could attack the body's cells and tissues. Mature T cells are stored in secondary lymphoid organs (lymph nodes, spleen, tonsils, appendix, and Peyer's patches in the small intestine). These cells circulate in the bloodstream and the lymphatic system. After they first encounter a foreign or abnormal cell, they are activated and search for those particular cells. Immune Cells Pathway for Tcell differentiation Types of T cells Helper T (CD4) cells help other immune cells. Some helper T cells help B cells produce antibodies against foreign antigens. Others help activate killer T cells to kill foreign or abnormal cells or help activate macrophages enabling them to ingest foreign or abnormal cells more efficiently. The Th1 response is characterized by the production of interferon gamma, which activates the bactericidal activities of macrophages, and induces B-cells to make opsonizing (coating) antibodies, and leads to cell mediated immunity. The Th2 response is characterized by the release of interleukin 4, which results in the activation of B-cells to make neutralizing (killing) antibodies, leading to humoral immunity. Generally, Th1 responses are more effective against intracellular pathogens (viruses and bacteria that are inside host cells), while Th2 responses are more effective against extracellular bacteria, parasites and toxins. Types of T cells Th1 cells: secrete IL-2, IL-12, IFN gamma, TNF-beta; activate macrophages, amplifying their cytokine secretion capacity and potential for presentation of antigens; activate synthesis of IgG but not IgE; are involved in delayed hypersensitivity reactions; are activated by signals from intracellular bacteria and viruses; Th2 cells: secrete IL-4, IL-5, IL-6, IL-10; activate the synthesis of IgE; stimulate proliferation and activation of eosinophils; are stimulated by allergens or parasite components. Types of T cells Killer (cytotoxic) T cells (CD8) attach to particular foreign or abnormal (for example infected) cells because they have encountered them before. Killer T cells may kill these cells by making holes in their cell membrane and injecting enzymes into the cells or by binding with certain sites on their surface called death receptors. Suppressor (regulatory) T cells produce substances that help end the immune response or sometimes prevent certain harmful responses from occurring. Sometimes T cells—for reasons that are not completely understood - do not distinguish self from nonself. This malfunction can result in an autoimmune disorder, in which the body attacks its own tissues. Types of T cells Γδ T cells (gamma delta T cells) represent a small subset of T cells, which possess a different receptor on the surface (TCR). Most T cells receptor consists of two chains α-and β-gp. Unlike T cells, γδ cells have a TCR composed of gamma and a delta chains. This group is more poorly represented than beta alpha cells. They are abundant in the intestinal mucosa. Natural killer T cells (NKT) are a heterogeneous group of T cells, which have properties of both NK cells and T cells and represents only 0.2% of all circulating T lymphocytes in the blood. The central role of Thelper cells (CD4) B cells B cells are formed in the bone marrow. B cells have particular sites (receptors) on their surface where antigens can attach. B cells are the major cells involved in the creation of antibodies that circulate in blood plasma and lymph, known as humoral immunity. In mammals there are five types of antibody IgA, IgD, IgE, IgG, and IgM, differing in biological properties. Each has evolved to handle different kinds of antigens. Upon activation, B cells produce antibodies, each of which recognizes a unique antigen, and neutralize specific pathogens. B cells The B-cell response to antigens has two stages: Primary immune response: When B cells first encounter an antigen, the antigen attaches to a receptor, stimulating the B cells. Some B cells change into memory cells, which remember that specific antigen, and others change into plasma cells. Helper T cells help B cells in this process. Plasma cells produce antibodies that are specific to the antigen that stimulated their production. After the first encounter with an antigen, production of enough of the specific antibody takes several days. Thus, the primary immune response is slow. Secondary immune response Whenever B cells encounter the antigen again, memory B cells very rapidly recognize the antigen, multiply, change into plasma cells, and produce antibodies. This response is quick and very effective. B cells Primary and secondary phases of the humoral immune response to the same antigen. Antigens Antigens or immunogens are substances foreign to the host that can stimulate an immune response. Most antigens are macromolecules such as proteins and polysaccharides, although lipids and nucleic acids occasionally can serve as antigens. Antigens include: bacteria fungi viruses protozoans parasitic worms substances such as pollen venom transplanted organs Antigens Antigens, which in general are large and complex, are biologically degraded into smaller chemical units or peptides. These discrete, immunologically active sites on antigens are called antigenic determinants or epitopes. It is the unique molecular shape of an epitope that is recognized by a specific receptor found on the surface of the lymphocyte or by the antigen-binding site of an antibody. A single antigen may contain several antigenic determinants; each can stimulate a distinct clone of lymphocytes to respond. Smaller substances (molecular masses <10,000 daltons) usually are unable to stimulate an adequate immune response. Low–molecular-weight compounds, known as haptens, combine with larger protein molecules they function as antigens. Antigens Multiple epitopes on a complex antigen being recognized by their respective (A, B, C) antibodies Immunoglobulins - structure Classes and Characteristics of Immunoglobulins Class Percentage of Total Characteristics Ig G 75% • Ig A 15% • Ig M 10% • Ig D 0.2% • Ig E 0.004% • Displays antiviral, antitoxin, and antibacterial properties • Only Ig G crosses the placenta • Responsible for protection of newborn • Activates complement and binds to macrophages Predominant in body secretions, such as saliva, nasal and respiratory secretions, and breast milk • Protects mucous membranes Forms the natural antibodies such as those for ABO blood • Antigens • Prominent in early immune responses • Activates complement Found on B lymphocytes • Needed for maturation of B cells Binds to mast cells and basophils • Involved in parasitic infections, allergic and hypersensitivity reactions Active Versus Passive Immunity Active or acquired immunity Can be achieved through exposure to a specific antigen. It is acquired through immunization or actually having a disease. Active immunity, although long lasting once established, requires a few days to weeks after a first exposure to become sufficiently developed to contribute to the destruction of the pathogen. Active Versus Passive Immunity Passive immunity Is immunity transferred from one source to another source. (e.g. An infant receives passive immunity naturally from the transfer of antibodies from its mother in utero and through a mother's breast milk.) Passive immunity also can be artificially provided by the transfer of antibodies produced by other people or animals. Some protection against infectious disease can be provided by the injection of hyperimmune serum, which contains high concentrations of antibodies for a specific disease, or immune serum or gamma globulin, which contains a pool of antibodies for many infectious agents. Passive immunity produces only short-term protection that lasts weeks to months.


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Silk Road
US Justice System Used Tactics Against Opponents That Are Considered Criminal
Ross Ulbricht, the creator of the Silk Road, an anonymous website known for selling drugs and using Bitcoin, was arrested and sentenced to two consecutive life sentences plus 40 years! Ulbricht was used to discourage other people from using private cryptocurrency. This interview with his mother is a cry of despair against politicians, prosecutors, and judges, who get away with falsifying evidence, withholding evidence, conspiracy to deny the right to a fair trial, and outright lying in order to punish those who become role models for the use of cryptocurrency instead of government-issued money.

subset: commoncrawl


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Here Are More Resources On Staying Healthy And Safe This Summer
Whether you are expecting a baby, protecting your kids during summer fun, monitoring your cardiovascular health, or seeking urologic surgery solutions, Los Robles Hospital & Medical Center can help. Visit the following links or call (805) 497-2727 for more information on staying healthy throughout life:
- Find out how the da Vinci Surgical System can help treat a variety of urologic conditions on this page from daVinciSurgery.com.
- Visit daVinciHysterectomy.com to learn about the different types of hysterectomy and how da Vinci surgery compares to other treatment methods.
- This article from the American Heart Association offers tips on incorporating healthy foods into each meal.
- Learn how to prevent obesity and maintain a healthy weight on this page from the National Heart Lung and Blood Institute.
- The American College of Obstetricians and Gynecologists explains how to stay physically active during pregnancy.
- For a comprehensive guide to remaining healthy throughout your pregnancy, visit WomensHealth.gov.
- Check out this page from ChooseMyPlate.gov to learn what nutritional choices are best for pregnant women.
- Learn what cholesterol is, which foods contain it, and why it is important for parents to monitor their children's cholesterol intake with this article from KidsHealth.org.
- This information sheet from RedCross.org provides tips on keeping children safe in and around water.
- Don't let a medical emergency ruin your summer fun—read this page from the Consumer Product Safety Commission to learn how to avoid accidents during outdoor activities.
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One of the many hats my husband wears is that of a magician. These pictures were taken at my middle sons third birthday when my husband put on a magic show for the "party" (just us and my brother-in-law were there.) The boys had a great time!
I didn't really start out with the intention of this page looking patriotic but I found that all of my sons were wearing red tops with white lines or figures and they all had on navy bottoms. And then to beat the band my husband had a red cape and jeans. I just couldn't ignore the colors, after all, they're what draws a page together. So, here the patriotic looking birthday pages.
On the left-hand page I stamped the snowflakes from Snow Swirled in Real Red and Night of Navy to add at a little pizazz. There are two clear buttons tied with Twine over the snowflakes in the journaling area for a little texture. I used Real Red wide grosgrain ribbon also on the journaling area and a Real Red piece of cardstock with the scallop punch below it. In the upper left corner I made a magicians wand and hat using some of our punches and then drew on little lines with a White Signo Gel Pen.
The White Signo Gel Pen was also used in conjunction with the Paper Piercer from the Crafter's Tool Kit to make it look like I sewed two lines around the outside edges of the pages. "Sozo the Magician" was cut out using the Big Shot and Go Go Boots dies.
I still need to add the journaling but there you have my scrapbook page. I wish I had taken a picture of the page I made at my party today that was based on the left-hand page of this layout. I used the same idea but with Flower Fancy stamp set and the colors of Regal Rose, Lovely Lilac and Gable Green. There wonderful colors for a bright little girl page! Since I don't have a little girl . . . .
I hope this has inspired you to do some of your own creating! Have a wonderful weekend!


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Punches are fun tools to use, but they can be a real pain to store. If you've got your punches dumped into a bin or tote, there's a good chance you're not using them because they're a pain to get to.
Remembering what you have can also be a challenge when your punches are piled up in a box or bin. Consider getting your punches organized and cagaloged. Once the catalog is complete, you're sure to use these expensive tools much more often.
Read my next post for tips and tricks on how to create a punch catalog.
Before you create a catalog you'll need to choose storage tools. Here are a few of the storage tools we offer and my recommendations for who should use them.
These handy little bags come in 3 depths - 1", 1.5" and 2".
Ideal for crafters who need to move their punches around - either off a shelf to a workspace or off the shelf to a crop tote.
One big benefit - these bags can be labeled down the side and then arranged on a shelf like a library.
Desk Maid Organizers
These are ideal for people who craft at home and have space available on a work space or shelf. The big benefit to these - visibility and accessibility, which means you'll use them more.
Don't have a lot of punches? Try storing them in something that is easy to carry to your work space but equally easy to put back on the shelf. Our Ditto Bag is a good example. This bag folds in half for carrying put opens on your desktop for easy access to everything.
Thanks so much for stopping by today. If you have questions about punch storage please feel free to use the comment box below. I'll get back to you as soon as I can.
Happy Crafting!


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This rich, velvety slow-cooked applesauce is perfect served chunky and warm. That's how I've eaten this dish since I was a kid every year around this time. There are a few things that really bring each new autumn home for me. One of those is the smell of baking apples. I could fill a book on all the things I love about this time of year, but I'll stick with apples for now!
There are many different ways to make applesauce. I've tested quite a few of them. I found that slow-cooking brings out a lovely richness and beautiful caramel color. The warm flavors of cinnamon and brown sugar that infuse this applesauce make it great to eat by itself or to add into a favorite dessert for a little extra punch.
How to use slow-cooked applesauce in other desserts
You can eat applesauce as a snack or a side, but what else can you do with it? Here are a few things you can add it to.
- Cake mix
- Oatmeal
- Ice cream topping
- Banana bread
- Brownie mix
Slow-cooked applesauce is super simple to throw together. Plus, you'll get that wonderful home-made taste that is a reward all by itself.
Start by peeling the apples and adding them to the pot. Next, toss in the sugars, cinnamon, lemon juice, and spiced apple cider. Stir that all together and cook on low for 3-4 hours. You can leave chunks of apples if you like, or use an emulsifier or blender to make it a bit smoother.
If you've ever been to London, you'll commonly get a side of warm, chunky applesauce with your burger and pub chips.
Slow-cooked Applesauce
- slow-cooker
- 3 lbs red apples
- 3 lbs green apples
- 1 cup apple cider
- 1 large lemon
- 1/2 cup brown sugar
- 1/4 cup granulated sugar
- 1 teaspoon cinnamon
- Peel, core, and slice all apples.
- Add apples, cider, lemon juice, sugars, and cinnamon to the slow-cooker.
- Stir this all together.
- Set the slow-cooker on low to 4 hours. Stop cooking after 3 hours.


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"PEOPLE ARE OUT of work, they're close together all day long, they have more time on their hands, they're drinking more, and they're taking out their anger and frustration on others." The words of Beth Casady, the executive director of the Women's Center in Marquette, warning us that domestic abuse will likely be on the ... Read More
It's Not a Cure for COVID-19, But….
"IT'S NOT A CURE--I'm not saying that--but it's most effective treatment we have out there now. There's not even a close runner-up, and it's certainly better than doing nothing." That's Spencer Stang, the CEO of Marquette's Stang Decision Systems, commenting on hydroxochloroquine (HC), the controversial anti-malarial ... Read More
The Bandanna Dilemma, Lakenen Love, Supermarket Adjustments, and Radio Deals with Reality and Remotes
To wear or not to wear SO NOW WE'RE hearing that it might be a good idea for all of us to wear masks--even makeshift, homemade ones--in public. Another way to flatten the curve. Dr. Kevin Piggott, the medical director of the Marquette County Health Department, gives the recommendation a qualified endorsement. "As ... Read More
Outward Calm, Inner Turmoil
SCENES FROM THE Queen City of the North, Springtime, early evening, forty degrees Light from the setting sun is filtering through the trees, Casting shadows. A j0gger, clad in NMU green, pounds the pavement, A father and daughter play catch on their front lawn, A solitary bicyclist pedals her way ... Read More
Where's Greg Trick Been? How Are the Restaurants Doing? And Has Spring Arrived?
A 14 day quarantine YOU MIGHT HAVE noticed that Greg Trick hasn't been anchoring the TV6 news for the last few weeks. True, he and his wife Aoy had been vacationing in Thailand, but there's more to the story than that. They shortened their trip when the COVID-19 threat became serious back in the States, and returned ... Read More


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Playgrounds of the world: Splash of colour in Bucharest
This photo is a courtesy of Ioana from The Happyholic. Ioana and her works are as colorful and positive as this little playground here. If you want to read more about her super-duper RO+MANIA project, jump over to Eastok Europe, you will see some cool stuff there. Beware, she will tell you NOT to go to Romania and you'll just want to go after.
See other Playgrounds here.


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We use a heuristic approach to speculate in which way the price is going to move during the next 60 seconds. He should be capable of good supervision and be able to train the pupils in a way that he himself becomes dispensable. This how to earn money using forex coordinates their physical and mental powers. Valeant was a stock held in the portfolios of many hedge fund managers. Merits of Heurism or Heuristic Method The following are some merits of heuristic method. That is, trial-by-error learning. Common Mistakes in Applying the Heuristic Method As stated earlier, the scientific method attempts to minimize the influence of the students bias on the outcome of an experiment.
The Heuristic Strategy
By following the instructions provided in the written form, students perform the experiment. (50, 100, etc.) Lastly, theres nothing particularly spectacular about the performances until we get to heuristic strategy trading the high 100s and the 200 day SMA, at which point, we see a stable region of configurations with high ranks in all categories. We also need an RSI reading below 20 to happen at the same time. In heuristic method, the entire task is completed in school. Heuristics are a flexibility technique for quick decisions, particularly when working with complex data. This creates scientific attitude in pupils. Hence, this method is not appropriate. On the other hand, if we believe the current value will go down in the near future, we buy a Put option. Learning by this method, pupils leave school with little or no scientific appreciation of their physical environment. V Decide on the method, techniques and tools to use v Explain the rationale of each vis-à-vis the statement of the problems v Describe the tool development process or use of existing one v Describe how you will gather data for the topic. Introduction and Theoretical Rationale, in an introduction, the teacher, create interest in the topic, lay the broad foundation for the problem that leads to the study, The objective is to test or verify theory. . Statement of the Topic, a good problem statement begins by introducing the broad area in which present learning is centred and then gradually leads to the more narrow questions. Here are the results for cumulative returns and Sharpe ratio: rankComparison(retsList).8485374 Basically, the interpretation is this: the outliers above and to the left of the main cluster can be interpreted as those having those few lucky months.
For success of this method a teacher should act like a guide and should provide only that much guidance as is rightly needed by the student. Whether it be commodities (Gold, Oil or Silver Forex exchange currencies (EUR/USD, GBP/USD or USD/JPY or stocks (Amazon, Tesla or Twitter). This method is successful if well-equipped libraries, laboratories and good textbook written in heuristic lines are available. Along with the RSI settings adjustments, we also played around with the overbought and oversold readings. The knowledge is gained by self- activity and hence it is retained for a longer time. Moving forward, its time to put the RSI indicator in use and spot if we have extreme oversold reading or not. The main reason were interested in learning about trade binary options is the fact that binaries simplify what were already doing in Forex.
INR ( Indian Rupee )
How to trade binary options depends on our trading skills. If you manage to count 50 candle low, obviously the starting candle point will be your 50 candle low. Heuristics are a problem-solving method that uses shortcuts to produce good-enough solutions given a limited heuristic strategy trading time frame or deadline. All you need to do is ask yourself a simple yes or no question. Here is a sequence of logical steps for planning and conducting research. In this method the teacher sets a problem for the students and then stands aside while they discover the answer.
Furthermore, the correlation.85 also lends credence that this is a robust strategy. By changing the RSI overbought and oversold line, we have eliminated the noise. The principle of logical thinking. Being wrong means you incur a loss. Sometimes common sense and logic tempt us into believing that no test is needed. Analysts in every industry use rules of thumb such as intelligent guesswork, trial and error, process of elimination, past heuristic strategy trading formulas and the analysis of historical data to solve a problem. The market can only go up or down. Definitions of Terminology/Concepts and terms used. Discovery of a thing needs hard work, patience, concentration, reasoning and thinking powers and creative abilities. This solves the problems of home work automatically. Hindsight BiasHindsight bias is the misconception, after the fact, that one "always knew" that they were right. You cant start hitting home runs right out the gate without making sure you have a binary options broker who wants you to succeed. Data Collection Data gathering includes consideration about what variables to investigate, Outline the general plan for collecting the data.
The hypothesis is a simple statement that defines what you think the outcome of your experiment will. The RSI default settings need a little bit of adjustment if you want to master the 1 minute time frame. The more confluence factors you have in your favor the more accurate the reversal signal. Objectives of Heuristic Strategy, the following are the main objectives of Heuristic strategy: To develop among students the ability of self-learning. A popular shortcut method in problem-solving is Representativeness Heuristics. Additional Resources, thank you for reading this CFI guide to the representativeness heuristic and its place in financial decision making. In this method teacher should avoid the temptation to tell the right answer to save time. In this demonstration, were going to look at the buying Calls.
What is, bitCoin, address - Get Bitcoin Address for Free - Tricks
Heres the process repeated with the annualized Sharpe ratio: rankComparison(retsList, perfAfun"nualized.8647353 In other words, an even clearer relationship here, and again, we see that the best performers overall are also the best monthly performers. We are also controlling the risk. It is a long and time consuming method and so it becomes difficult to cover the prescribed syllabus in time Hence, it is impossible to search out the knowledge as a result of pupils self-efforts for a period. The main feature of scientific work is that it springs from a desire to know from our own knowledge some definite thing concerning which curiosity has come to an end. It focuses on the fact that investors are not always rational. It may be suggested that at least a heuristic approach prevails for teaching of science in our schools. Ideally, the scatter plot would go from lower left to upper right in terms of ranks comparisons, with a correlation of 1, meaning that the strategy with the best overall return will have the best average monthly return rank, and so on down the list.
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Keep in mind that in order to move to the next step, we need the 50 candle low. But it is more responsive to the immediate price action. It develops scientific attitudes among students by making them truthful and honest for they learn how to arrive at decisions by actual experimentations. It creates clear understanding. A company may be excellent heuristic strategy trading at their own business, but a poor judge of other businesses. This post is motivated by a discussion that arose when I tested a strategy by Frank of, trading, the Odds (post here ).
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Power of observation and reasoning and drawing inference are heuristic strategy trading developed. . The final step in the scientific method is the conclusion. She majored in economics at university and, as a student, she was passionate about the issues of equality and discrimination. The crash of Valeant Pharmaceutical International was a shock to investors when the company saw its stock plunge to 2016. That is, when testing an hypothesis or a theory, the students may have a preference for one outcome or another, and it is important that this preference not bias the results or their interpretation. For this method, special books, devices and trained teachers are needed. An important thing to remember during this stage of the scientific method is that once you develop a hypothesis and a prediction, you shouldnt change it, even if the results of your experiment show that you were wrong.
Lets imagine the following scenario: Consider Laura Smith. This method insists on truth, whose foundation is based on reason and personal experiences. But walk away with 75, even 95 winning trades because we only needed to get the direction right. But that is incorrect. The teacher should be convinced that road to scientific thinking takes time. This example is an excerpt from CFIs. At the same time, we need the RSI indicator to move higher in the opposite direction.
This prepares them to solve any problem likely to arise in future life. Heuristic method is useful only for the pupils of higher classes and not for lower-class pupils. 2) Pertaining to the use of the general knowledge gained by experience, sometimes expressed as using a rule of-thumb. This is where our TSG team comes to the rescue. It also includes the subsequent effects on the markets. Will the price of the underlying asset be worth more than the strike price at the expiration date?
Best Forex School bestforexschool) Twitter
Txt format"Y-m-d sep headertrue) xiv - merge(xiv, ratio, join"inner vxx - merge(vxx, ratio, join"inner colnames(xiv)5 - colnames(vxx)5 - "ratio" xivRets - lculate(Cl(xiv) vxxRets - lculate(Cl(vxx) retsList - list count - 1 for(i in 10:200) ratioSMA - SMA(ratio, ni). The term seems to have two usages: 1) Describing an approach to learning by trying without necessarily having an organized hypothesis or way of proving that the results proved or disproved the hypothesis. It provides scope for individual attention to be paid by the establishing cordial relations between the teacher and the taught. An RSI reading below 20 shows that the market is in oversold territory and it can potentially reverse. At the same time, binary options also allow us to make more heuristic strategy trading money in the process. Teachers should be ready to accept any suggestion for the solution of problems regardless of how irrelevant it may seem to him, for this is really the true spirit of scientific problem solving. His shortcut approach, although it saved reviewing data for both companies, may not have been the best decision. Moving onto the 100-day SMA region, the annualized returns and Sharpe ratios are strong, but get the parameter estimation incorrect going forward, and theres a severe risk of incurring heavy drawdowns. Evaluation of learning through heuristic method can be quite tedious. According to him, the real spirit of heuristic method is placing the student in the position of original investigator which means involving his finding out instead of being merely told about things. This can also apply to the Sharpe ratio, and. She is 31, single, outspoken and very bright. . XYZ may have food that is not appealing to Indian consumers, which research would have revealed. .
The acceptance of and the quest for unique heuristic strategy trading solutions for the problem that the class is investigating should be a guiding principle in the teachers approach to his programme of science. The more one experiences losses, the more likely they are to become prone to loss aversion. Representativeness heuristic bias occurs when the similarity of objects or events confuses peoples thinking regarding the probability of an outcome. Whatever students do, they keep note of them in their note books. Our team at Trading Strategy Guides is ready to share with our beloved trading community our 60-second binary options strategy.
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The jump improvement in the drawdown metric is also interesting. So, the first thing you need to decide upon is to select the asset to trade. If you want to buy Put binary options, use the same binary options guide, but in reverse. When you count the 50 candle low, you should always start from the current candle. Four general purposes for conducting learning through heuristic method are to explore, describe, predict, or explain the relation between two or more educational variables. To develop among students the ability of critical thinking.
The expiration time will ultimately determine if youre making a profit or not. Now its time to highlight how to find the right entry point for the binary options trading strategy. We figured out the same thing that weve been doing in Forex can be done. Double Digit Numerics, the original author of the paper that. To develop among students the scientific thinking. Teacher keeps on guiding the students for conducting the experiment properly from time to time. If you have contract or full time roles available for proprietary research that could benefit from my skills, please contact me through my LinkedIn here. Explore an attempt to generate ideas about educational phenomenon Describe an attempt to describe the characteristics of educational phenomenon Predict an attempt to forecast an educational phenomenon Explain an attempt to show why and how an educational phenomenon operates. Lastly, on the nature of the strategy itself: while Trading The Odds presented a strategy functioning on a very short time frame, Im surprised that instead, we have a strategy whose parameters are on a much higher end of the numerical spectrum.
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The good news is that the best binary options strategy is exactly that system. If youre right on the market direction by the time of the expiration time, you earn a profit. Your forecast needs to be accurate during a certain time frame called the expiration time. The success of any method depends on unambiguity and clarity on each inherent aspect. An incorrect prediction does NOT mean that you failed. The students are immature and it is difficult for them to draw conclusions. This signals a potential reversal signal. Representativeness uses mental shortcuts to make decisions based on past events or traits that are representative of or similar to the current situation. New equity highs are followed by strong drawdowns, which are then followed by a recovery and new, higher equity highs.
Thank you for reading! It is designed to help you decide whether you like to trade binaries and learn about the trade binary options. The methods make them exact and bring them closer to truth. The heuristic I decided upon was to take some PerfA functions (nualized, nualized, for instance and compare the rank of the average of their monthly ranks (that is, a two-layer rank, very similar to the process in Flexible Asset Allocation). It is used to predict where the current value will be some time in the future. In this step, the pupils collect facts by experiments in favor of or against the hypothesis. If you prefer to play it safe over gambling, you need a strategy or tactic to help you master binary options and other trading activities. Heuristic, Hindsight Bias and Nave Diversification. In words of Professor Armstrong, Heuristic methods of teaching are methods which involve our placing students as far as possible in the altitude of the discoverer methods which involve their finding out instead of being merely told about things. . When we first discovered binaries, the light bulb in our heads turned. We recommend highlighting the starting point on your charts. In this method too much stress is placed on practical work which may lead a student to form a wrong idea of the nature of science as a whole. This is a psychological method as the student learns by e maxim learning by doing is involved.


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Arrived 3 p.m. I was to have tad tea with Kuchik Khan at Resht, but he cannot arrange before Wednesday [28th August] and I cannot wait so long – so I must again return without accomplishing this important work. Enzeli is looking very nice and clean. Bray is very ill and I sent him to hospital and taken on Lieutenant Grosvald of the Russian Army in his place – a good fellow, but not a patch on Bray.
1918 – August 7
The Port here is quiet, but although we have arrested and sent to Baghdad the Bolshevik leaders, we cannot yet get real control of the port and the shipping, as I have very few troops and cannot show force. In fact, the Bolsheviks or the Jangalis or both together might attack me at any time and knock me out. One has to take big risks but I must send all I can to Baku and keep only the minimum here.
I have had bad diarrhoea for some time and on the road down I felt as if I were going to die – I determined to eat nothing, but at the Nagober toll-gate I had to accept hospitality and I was hungry, so I gave in and drank tea and coffee and ate cheese and omelette. After that I nearly died again and gave up worrying, so when we got to the Resht toll-gate and I was again tempted, I ate everything I wanted. Bray suggested a Russian cure, vodka with pepper in it, so I drank three pepper vodkas which were very consoling! and from that moment to this I have been as fit as a fiddle – it was, I suppose, too much for the microbes.
When one arrives in a new town, one is deluged with interviews that tire one to death. Yesterday I had M. Hunin, head of customs. Khachikov and Senizavin, controlling the Caspian fleet, Gendre, the Social Revolutionary, Dr. Araratiantz, head of the Armenian National Council, Mr. Ogamiantz, Soc. Rev. Alkhari – Bicherakov's man; great schemes are propounded, but each is playing for his own hand. To-day I have already had heaps of time-wasters, mostly Russian and British refugees trying to get a job – (that is, money) out of me. Baku still holds up and I hope Bob will pull through, but my reinforcements are small and time flies.
[I cannot identify the location of Nagober but I believe it to be somewhere in Iran]
1918 – August 5
Passed through Resht and had lunch there at the tollgate and talked with Matthews and Moir who have done very well. We recently bombed by aeroplane all the Gilan towns and I do not think they will attack again. Resht is much damaged, but town seems quiet and no shots were fired at my convoy. The country was more beautiful than ever, the wonderful 20 miles of forest and the green rice-fields below. Arrived Enzeli 6 p.m., staying in the fisheries' same old house. We have just arrested the leaders of the Russian Revolutionary Committee and I think all will go well. 6 months ago Cheliapin was on the verge of arresting me and I had to flee in haste – to-day he is on his way to Baghdad and the Revolutionary Committee exists no more while I hold Enzeli. Bob is in Baku and the news from there is not so bad – we may be able to hold out.
1918 – August 4
Baku is on the verge of falling, but we may be able to save it – I have sent Bob on and leave myself to-day for Enzeli. Arrived Menzil, the little post-house there very uncomfortable with Baku and Resht refugees.
1918 – July 23-24
To Kasvin – a dreadful journey. 4 hours' engine trouble. 6 punctures at last ran in by moon-light on the rims to Kirk Bulak [place unidentified] and telephoned from there for another car which arrived at 3 a.m. and got us in by 6 a.m., on the 24th. Glad to be at home – sick of travelling. 780 miles in car and 220 in aeroplane. While I was away much has been doing. The Jangalis have recaptured Resht and we had 50 casualties.
1918 – July 1
Returned from Enzeli. The down journey was quite uneventful and the country looked very different to what it did in the winter. No shots were fired either out or on the return journey, though several battles took place on the road in between while.
Stayed the night at Menzil – next day passed through Resht and down to Enzeli. It was nice to see the sea again – lived in the same quarters as before. Next day sea-bathing on nice sandy beach and the Caspian was delightful. Long final interview with General Bicherakov and final settlement of plans in South and North Caucasus. Then long interview with Cheliapin the leader of the Revolutionary Committee who wanted to arrest me in Feb., and was responsible for my not reaching Baku – he is very stupid and not more amenable now than he was then. One can deal with anything except blank ignorance. Finally he said: "I cannot continue to talk with one who subjects himself to the domination of a King and a Crown!" Left Enzeli same afternoon, arrived Resht for dinner. Stayed next day interviewing new Governor, Sirdar-i-Kul*, pro-Turk and pro-German, but now pro-me (temporarily), arranged a great function for rehoisting of British flag. All consuls present – troops armoured cars, Persian official. I made speech, flag hoisted. Persian police marched past and saluted flag. Persian Commandant made apology.
Good fight at Iman-Zadeh-Hashem, on the road outside the town – Gurkhas captured and burnt a village and killed many of the enemy. Two officers took two Polish women out for a drive in motor-car – silly asses. Drove straight into the enemy. One officer 2 women killed, car captured. One officer escaped and now to be tried by Court-Martial.
* I cannot find anything out about this person but Sirdar-i-Kul means 'chief or commander of all', so it is likely to be an honorific rather than an actual name.
1918 – June 1
Arrived Kasvin with 22 Cars, 14 hours run, 140 miles, no incidents. Very nice house here, but hotter than Hamadan, still it is a beautiful place with Gardens and nightingales and it is nice to have a couple of blankets at night.
My troops are getting all over the place, as I have so many different situations to deal with. I have sent Wagstaff with 80 officers and men towards Tabriz to worry the Turks and raise the Shahsavan tribes – he can't get into Tabriz because the Turks are already there and I have no troops to drive them out with. I have another party of 60 gone to Bijar to raise the Kurds and raid the Turks. I have 20 of the Hants here, 1 Squadron of the 14th Hussars and 2 armoured cars: at Hamadan 140 miles away I have another 100 Hants, 4 Armoured Cars. At Kermanshah, 140 miles further away I have 8 armoured cars and 1000 infantry, travelling in 500 Ford cars as a mobile column, and I have 3 aeroplanes.
All this to run 350 miles of road – keep the Turks out of Azerbaijan, help Bicherakov to knock Kuchik Khan's revolutionary army off the Enzeli road and try to save Baku from the Germans. I am trying to run Bijar, 180 miles west of this, Hamadan 140 S.W. Tabriz, 300 miles N.W. Enzeli-Baku, 400 miles N. and Teheran 100 miles East. The Russian Officers that I take as refugees are a great source of trouble to me, as I cannot find employment for most of them and they cost Government a great deal of money. General Baratov, who commanded the 1st. Caucasian Corps, I sent down to Baghdad, but they are sending him back, also General Lastochkin. Colonel Baron Meden and wife go to Baghdad in a day or two, also Colonel Masoyedov – and I have 25 others here, younger officers, whom I can employ though they are not really of much use.
I am now planning to march to Enzeli with Bicherakov's 1000 Cossacks and 1 Squadron 14th Hussars – to capture the Menzil Bridge, Resht, and Enzeli and get over to Baku. I do not know if Kuchik Khan means to fight. I sent Colonel Stokes down two days ago with a flag of truce to see Kuchik Khan to tell him that I do not want to fight him, but I will have the road clear, and I will have the prisoners released and he can do what he likes about it. He will have to fight. I am anxiously awaiting Stokes' return.


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text: GEORGE Bowyer believes it was wrong for a rural school to block its children from watching a fox hunt. But as the joint master of the Fitzwilliam Hunt, based in Peterborough, you would expect him to put forward this view. Mr Bowyer believes children, including those at Ashbeach Primary School in Ramsey St Marys, whose trip to a hunt was cancelled following a complaint from a parent, need to experience both sides of the fox-hunting debate and be allowed to make up their own minds. Each side of the hunting debate is passionate, he said. Using a balanced approach in the classroom is a good thing. Actually going out to see a hunt for themselves isnt unbalanced, as long as the other side of the argument is also presented. Age should also not be a barrier to watching parts of a hunt. Mr Bowyer has been hunting since the age of six and said it was important for young people to gain an appreciation of the reasons behind fox-hunting which, he argued, was used largely as a means of fox-control. There are many different types of hunting, he added, but most of them are merely fox-control activities. By taking children on a trip to watch a hunt they would see the person riding ahead, dragging the scented rag along the ground. They would see the hounds and the huntsmen, but its highly unlikely they would actually see an animal dying. The Fitzwilliam Hunt is over 250 years old and its masters are regulars in Cambridgeshire primary schools, offering to educate children about the sport. The anti-hunt argument is very black and white, he told The Hunts Post. They say the foxes are frightened, that fox-hunting is cruel and should be banned. But we try to get people to see that every single fox dies a horrid, nasty death anyway most of them starve to death or are snared or trapped. Mr Bowyer added that the nature of hunting meant that most hunt riders seldom saw a fox being killed. Its not a case of the nasty hunters getting pleasure out of seeing the killing of a fox, he added. They are usually three or four fields away. The Hunts Post asked Ashbeach School whether it debated both sides of the fox-hunting argument with the Year 6 children who were scheduled to go on the trip on February 7, but staff declined to comment.


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The National Secondary Schools Sports Association (NSSSA) held its national high schools softball tournament on Friday and Saturday, March 11-12, in Punta Gorda, and the results indicate that the finals in both female and male matches were exciting indeed, as both were decided by 1 run only. The games were played at two venues, the Toledo Union Field and the Cattle Landing Field, and were hosted by Toledo Community College. Participating teams represented the 4 country zones – North, Central, West and South.
The tournament followed a simple knockout format, with Friday's losers playing on Saturday for 3rd place, while Friday's winners clashed for the championship on Saturday.
Both female games on Friday were decided by the "mercy rule", as Nazarene High (Central) blasted Belmopan Baptist (West), 18-8 (WP – Amber Wade; LP – Shanelly Ho); and Belize Rural High (North) trounced Stann Creek Ecumenical (South), 16-3 (WP – Kayle McFadzean; LP – Desiree Hulse).
The male games were different. The NSSSA report said that Belmopan Comprehensive (West) defeated SJC (Central), 7-0, by "forfeit", but then went on to say that umpires stopped the game "for safety reason". Our inquiries revealed that the umpire's decision to award the game to BCS was as a result of serious misconduct by an SJC player. The other male game was a 12-11 victory by Independence High (South) over San Pedro High (North) (WP – Keenan Moguel; LP – Konrad Gonzalez).
The pattern continued on Saturday, with the female 3rd place game ending by the mercy rule, 20-0, with Stann Creek Ecumenical winning over Belmopan Baptist (WP – Desiree Hulse; LP – Shanelly Ho); and the male 3rd place match being another "nail biter", with SJC edging San Pedro High, 8-7 (WP – Myric Marin; LP – Konrad Gonzalez).
The championship games, however, both went "down to the wire". Reports are that the female championship game went down to the bottom of the last inning, with Nazarene High emerging victorious, 15-14, over a game Belize Rural High (WP – Amber Wade; LP – Kayle McFadzean). And in the male championship game, with the game halted early due to darkness, Belmopan Comprehensive got the 4-3 win over Independence High (WP – Jose Hernandez; LP – Keenan Moguel).
Female MVP for the tournament was Nazarene's pitching ace Amber Wade who had 13 strikeouts in 2 victories; and male MVP was Compre's Jose Hernandez who had 10 strikeouts in 2 victories.
(Information courtesy of NSSSA release.)


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High Yield Bonds
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Zee Telugu'Äôs dance reality show Aata Juniors is making a comeback to the channel starting this weekend. It provides a platform for those who aspire to make their dreams come true in line with the channel'Äôs brand philosophy 'ÄúAarambham Okka Aduguthone'ÄĚ. From August 25, viewers will witness the talented little stars battle it out to win the title of Zee Telugu'Äôs Aata Junior. It will be telecast on Zee Telugu and Zee Telugu HD, between 9 pm and 10 pm, every Saturday and Sunday.
This time, it chose 12 out of thousands of children who participated in auditions that were conducted across Andhra Pradesh and Telangana, along with videos shared for online auditions from Bengaluru and Chennai.
Hosted by anchor Ravi, the popular host from Zee Telugu, the highlight of this season is the introduction of the new format that includes six choreographers, six super-dancers  and the 12 hand-picked contestants, where each contestant will be paired with a choreographer and super-dancer, to help each of them make the most of this platform. The teams will be judged by actress Lakshmi Manchu and Nataraj Master, the choreographer, dancer and actor. Nataraj will consider the stage presence of a performer, the entertainment quotient and dance technicalities, while a 12-member grand jury panel will mentor the contestants.
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The Shakeout Podcast: All's fair in love and running
This week we dive into the relationships of some of Canada's top runners
February 15th, 2019 by Kate Van Buskirk | Posted in The Shakeout Podcast | Tags: Featured, kate van buskirk, Matthew Hughes, melissa bishop, natasha wodak, Valentine's Day
This week on The Shakeout we dive into what it's like to be a runner's partner. We bring you the story of five different couples who are in a relationship with each other, but also with running.
RELATED: Melissa Bishop shares wedding day photo
RELATED: Get race-day ready with Natasha Wodak
This week's guests are Osi Nriagu, Alan Baggoo, Maddie Davidson, Jeremy Rae and Will Roumanis. All of these people are in a relationship with a runner. Some of our guests are, or were, runners in their own right and others have only discovered running through their partner. We gain their perspectives on the intricacies, frustrations and joys of being in a partnership with someone who's so invested in what they do.
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You can email the show at email@example.com | If you enjoy our podcast, leave a review and rating on iTunes!