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S o I dropped out, In elementary school I was the peaceful nerdy one, I just liked to go home and play computer games, school was not bad though, and I had pretty good relations with everybody, but as I got older (like by 3rd grade) I didn't really have any close friends, but everyone liked me, I figured I was like the halflings of dungeons and dragons, everybody's second best friend and it was a role I took on proudly! I never really did work outside of school, because I could pass the tests and I understood the lessons so I didn't really understand why we were doing it, it just seemed like busy work. It would always come up when report cards came around and I would say I just forgot, I forgot my homework. I hated the feeling of guilt but it was never enough to actually get me to do the work. Luckily I had a teacher, in elementary school who saw a poem I wrote and was dumbfounded by it, and by the end of the year he just let me sit in back of the class and write stories for most of the day, he was the best teacher I ever had, just for his sheer audacity, I mean, wow looking back he really taught me a powerful lesson, that things could change, and people out there do understand.
By the time I got to high school I was mostly the same, I realized life was just a joke and very much into spirituality taoism, zen, and the oneness of all things, as far as I was concerned school was just a time to meditate and practice kindness and be around interesting people, my grades were bad because I did no homework and even though I passed most tests and did well in class it brought my grades down a lot. I didn't care though, I had gotten used to the cycle, i didn't need praise. I just tried to live in the moment. I took a yoga class which I really enjoyed, and also began smoking weed, which I was convinced was the path to enlightenment. I first really understood meditation after I got high for the first time, and realized the world is not at all what we think of it in everyday reality, my concepts of life were shattered, I felt like I had seen God, and that all the spiritual ideas I had come across where making sense in a whole new light, it seemed like secretly everyone knew these things and that the universe was just a conspiracy to get back to this point, I was kind of suprised when I came down, I thought I would be there forever. But I certained gained a renewed since of confidence in my approach. Yoga also helped, I was lucky to have a school which offered this class, the teacher saw I was a good student and even taught some kundalini yoga to me, which I did later alone and ended up having an experience equal to when I first got high and even more so because no drugs were involved. I spent a lot of time walking around in nature, trying to clear my mind of thoughts, and just see things as they really are. Some amazing things happened and I learned to really be in the moment, I had no real worries then, it was the happiest time of my life, everything made sense to me.
Around this time I met a really good friend of mine, I began skipping school because I realized it just wasn't for me, and wasnt neccesarily the only way and I would smoke weed with friends because we had a pretty big stoner community or go off alone and meditate, make art, play guitar or study zen koans. Zen always had a very big appeal to me, because the masters were so aloof and yet so alive seeming, they just seemed like great people in every aspect, I wanted to be like them. But yeah, the friend, he had very hippie-ish parents who smoked weed and used to trip, and we ended up spending a lot of time together, he showed me books about Don Juan and talked about shamanism and I decided maybe that was the way for me, it seemed to resonate in me ,even though I wasn't exactly sure was a shaman was. The books were very interesting though.
Finally one day, another friend randomly gave me a call and asked me if I wanted to trip acid with him and I said YES. I had been smoking weed for about a year and I read so much about acid and the insights that it gave and the beautiful experiences people had I wanted to experience it for myself. So we took it and once again, my foundations were shattered. I lay in bed that night unable to sleep observing the world that I lived in, how it all was a reflection of me, I saw how the universe was created, and everything referenced back to a singular point. I realized that anything was possible then, and that I shouldn't let fear hold me back. So the next day I arose with a totally new outlook. I felt as if reborn, I felt like I had reached enlightenment for real. I was ready to start living life in my own way, regardless of others opinions.
I told my parents I wanted to drop out but they said no, so I kept going to school. Finally there was a break, my parents were angry because of bad grades again, and they had caught me smoking weed and since they had no experience with it themselves over reacted hugely and were

subset: commoncrawl


text:
Terazzo Confetti Cups
$6.99 was $8.00
This product is currently sold out.
With a modern color palette and pattern, these paper party cups would be great for a birthday brunch or modern Flintstones party. The random confetti pattern would be a great touch to your existing birthday party decorations.
8 pack paper cups


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The Play Company develops and produces adventurous new plays, from the U.S. and around the world, to engage New Yorkers in a dynamic experience of contemporary theatre that reflects and responds to both our New York City home and today's interconnected world. We support ambition and experimentation in both form and content. We champion new and marginalized voices to expand the American repertoire, exploring the ideas, events and meaning of our time through live theatre experiences. PlayCo is committed to affordable access and collaborative community engagement, welcoming inclusive audiences to take part in our work.
Jennifer Lim and Louis Ozawa Changchien in Caught, 2016.
Photo by Carol Rosegg
Since 1999, our body of work includes 37 World, American, and New York premieres of new plays from Japan, Mexico, Chile, Russia, India, Palestine, Romania, Italy, Poland, Germany, France, Sweden, the UK and the U.S.
New Work/New World
Production Series
The Play Company's central activity is producing World, American, and New York Premieres of new plays from around the world. We work with both new and established artists, emphasizing support for emerging American writers and the discovery of outstanding contemporary writers from abroad.
PlayCo complements its production season with an eclectic series of stand-alone events, including reading presentations of plays and literature, evenings that examine a particular topic through the work of a variety of prose and poetry writers and/or other media, and panel discussions featuring theatre artists, writers, scholars and community leaders. These events may link to a production, or extend our programming to other ideas or issues of interest to our community.
PlayCo offers artists an arena for exploring ideas and generating new work. Developmental tools range from in-house readings to public lab productions. The Studio supports both the investigation of ideas for its own sake, and the preparation of work for full production in our New Work/New World Series.
Our commissioning program for both original works and new translations of plays from abroad.
The Play Company is an international theatre for new writing, collaborating with playwrights from the U.S. and all over the world. We host writers in New York City so they can play an active role in our productions of their work, and to introduce them to the local community through events such as artist roundtables, panel discussions and audience talk-backs. The Residency Program also offers local students unique educational opportunities by engaging with visiting playwrights in special classes and workshops. Students of theatre, literature and foreign studies see the work of visiting writers in production and interact directly with these artists in subsequent classes to learn about different artistic traditions, practices and points of view.
Kate Loewald
Founding Producer
Kate created The Play Company with her late partners, Mike Ockrent and Jack Temchin, in 1998. To date PlayCo has produced nineteen world, American and New York premieres of plays from Sweden, Poland, Japan, Romania, India, Germany, Russia, France, Britain and the United States. The company received a 2007 OBIE Award for its "unique contribution to the Off Broadway theatre community".
From 1990-99 Kate was head of the literary department at the Manhattan Theatre Club, overseeing programming and creative development. She collaborated with many playwrights and directors on new plays, including Terrence McNally, Jon Robin Baitz, Richard Greenberg, Donald Margulies, Elizabeth Swados, Cheryl West, Kia Corthron, Joe Mantello, Mark Brokaw and Nicholas Martin, among many others. She created the MTC Playwriting Fellowships for emerging writers. She was also Director of MTC's acclaimed Writers in Performance series in 1998 and '99, producing an innovative program of literary events featuring such writers and performers as Walter Mosley, Norman Mailer, James Baldwin, Gish Jen, Alec Baldwin, Bill Murray, Buck Henry, Anita Desai, Robert Pinsky, Sydney Schanberg, and Arnold Wesker. Prior to MTC, Kate was producing associate to Margo Lion on George C. Wolfe's Jelly's Last Jam, Martha Clarke's The Garden of Earthly Delights, and other plays on and off Broadway.
Kate is on the adjunct faculty of the New School for Drama MFA program and the Fordham College theatre department, and has also taught in the Dramatic Writing Program at New York University. She was a dramaturg at the O'Neill Playwrights Conference from 2000-2003. She serves on the board of Backbone Media, a San Francisco-based documentary film company. She is a graduate of Yale College. In addition to her work with The Play Company, she was the Guest Artistic Director for the Signature Theatre Company in the 2004/2005 season.
Robert G. Bradshaw
Managing Director
[email protected]
Melissa Hardy
Director of Producing & Artistic Development
[email protected]
Joey Nasta
Development Assistant
[email protected]
JūLondré Brown
Literary & Community Engagement Fellow
[email protected]
Danielle Gutierrez
Marketing Fellow
[email protected]
Blake Zidell & Associates
[email protected]
Linda Bartholomai
Literary Consultant
Trip Cullman
Associate Artist
Literary Wing Readers
John Brunner, Dan Dinero, Noa Egozi, Taylor Barrett Gaines, Hunter Gause, Xintong Han, Christina Roussos, Anisa Threlkeld, Jeremy Tiang, Austin Tooley, Cynthia Tong Lyto Triantafyllidou
Board of Directors
Carmine Boccuzzi & Victoria Reese
Michael Dweck
Kate Loewald
Kyra Tirana Barry
Trip Cullman
Bruce Geismar
Ruth Hendel
Lawrence Kaplen
Philip Levy*
George Sheanshang
Patricia Heaton
David Hunt
Susan Stroman
* Philip Levy died suddenly on Thursday, October 12, 2017. Philip was a devoted and lively member of our community. The founder of Bridge Street Books in Washington DC, he was passionate about ideas and generous with his support for causes he believed in. We will miss him so much and we celebrate his life.
The obituary from The Washington Post: Philip Levy
Work with us
Below is a list of current and upcoming opportunities to join the PlayCo team as staff, intern, artist, or volunteer.
The Play Company (PlayCo), an award-winning, New York City not-for-profit theatre, offers fellowships in our Marketing, General Management, and Literary departments. We invite prospective applicants to attend information sessions where you can learn more about these opportunities and PlayCo. PlayCo fellowships provide mentoring and hands-on training to emerging theatre professionals of color, in our Manhattan administrative office, rehearsal studios and performance venues around the city, and professional development opportunities in and out of New York City. In addition to their practical training with the PlayCo staff, fellows will also receive professional mentorship. The Fellowship Mentor will support Fellows throughout the process, to create focused goals and professional development plans during their tenure, advise on any questions or issues that arise during the fellowship, and facilitate monthly in-person meetings to review, assess, and revise these goals as needed.
We are no longer accepting applications for PlayCo fellows. Please visit this site for future opportunities.
The Play Company is accepts applications in the areas of Producing, Marketing, Literary, Development, and Special Events. Our Internships offer excellent opportunities for emerging arts professionals to gain practical, hands-on experience in a professional and inclusive theatre setting. With mentoring from our staff, interns will collaborate on a diverse array of projects, and our goal is to provide tools & resources that enable interns to grow into qualified professionals in the field.
We are no longer seeking applicants for our Spring 2020 internship program. Please revisit this page for more information on Summer 2020 internships.
- Knowledge of the performing arts industry
- Reliable and detail-oriented
- Superior time-management and organizational skills
- Excellent writing and communication skills
- Ability to thrive in a fast-paced work setting.
- Strong sense of initiative and autonomous work ethic.
About The Play Company
The Play Company, PlayCo, is an OBIE Award-winning Off-Broadway theatre production company. Now in its nineteenth season, PlayCo develops and produces adventurous new plays from the U.S. and around the world to engage New Yorkers in a dynamic global experience of contemporary theatre, and expand the American theatre repertoire.
As the only New York theatre regularly producing outstanding contemporary plays from abroad alongside new American work, PlayCo's distinctive international programming links American theatre with world theatre, American artists with the global creative community, and American audiences with a whole world of plays.
Learning Opportunities
PlayCo fosters a positive learning environment for interns and invests in systems to ensure your experience will yield invaluable experience and skills across all disciplines. We afford interns the following opportunities:
- Monthly check-ins with your dedicated supervisor to create and assess learning goals, work plans, challenges, successes, and discuss any other aspects of your internship.
- Dedicated time with all staff members outside your area (i.e. marketing intern will sit down with the Director of Producing) to create a holistic perspective on creating professional theatre.
- Most internships will offer training in systems crucial to your discipline. (i.e. the producing internship will learn or bolster existing skills in Quickbooks).
- Monthly check-ins with the full intern cohort and intern coordinator to share experiences, troubleshoot challenges, and foster new professional relationships with your peers.
- Dedicated projects in your area to provide a meaningful experience that will bolster your resume for future opportunities.
Time Commitments & Stipend
The Internship Program will begin at or near the start of each school semester, including summer. Start and end dates are flexible. We ask for a minimum commitment of 20 hours/week for all internships. Weekly schedules are flexible to navigate class schedules and other employment.
PlayCo offers a monthly travel stipend by pre-purchasing an unlimited monthly MetroCard for all interns who commit to a minimum of 20 hours/week. Academic credit is also available where applicable.
To Apply
Please send a cover letter and resume to Robert Bradshaw, Managing Director, at [email protected] Please specify your area(s) of interest (Development, Production etc.)
The Play Company is committed to diversity, equity, and inclusion at all levels: on our stage, in our audience, on our staff, and within our leadership. We strongly encourage candidates of color and from under-represented communities to apply.
We are also accepting applications for future semesters for applicants pursuing internships in advance.


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NEWS-PRESS / SEARCH: 55 Boca Chica Road #455 Big Coppitt, FL 33040
- 1 beds
- 1 baths
- $192,000 price
- 589133 mls id
- Square Feet: 435 sqft
- Year Built: 1993
1 bd/1 ba located on a quiet cul de sac, in the section of Seaside Resort known as ''Fantasy Island'' just 10 miles from Key West. This elevated home has partial water views from the living room and the patio along with off street parking for two cars. The resort offers two pools (one heated) a gym, library, 24hr security, marina with boat ramp as well as inexpensive boat storage. Great boating to the Atlantic and the Gulf. The shed has washer and dryer hook ups. Perfect Keys home or vacation rental income property.
- Site Link
- Style Other Style
Courtesy of: Coldwell Banker Schmitt Real Estate Co.
Office Phone: +13052967727
Listing Agent: Sean Farrer
Updated: 6th April, 2020 5:51 PM.
55 Boca Chica Road #455 Big Coppitt, FL
Real Estate | News-Press Powered by Placester


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32-Inch Peanuts Pre-Lit 2D Rotating Yard Art Skating Snoopy with Woodstock On Skates
OFFICIALLY LICENSED: 2D Peanuts rotating yard art statue Christmas decoration set for indoor or outdoor holiday décor. A great gift for fans of the beloved 1965 animated Christmas special
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DURABILITY: Constructed of a durable metal frame covered in a soft and colorful fabric for a festive look and feel
ILLUMINATED WITH LIGHTS: Statue is pre-lit from inside by 35 clear LED lights and is perfect to use during the day or night for a great display
MEASURES: 32″ x 14″ x 29″
There are no reviews yet.
Only logged in customers who have purchased this product may leave a review.


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Joseph Audio RM33le Floorstanding Speakers
Joseph Audio RM33le Floorstanding Speakers
[Sep 24, 2005]
Top to bottom coherence and musicality, more efficieint than the db rating would suggest.
Climbing at such high altitudes demands greater aerobic fitness in the heart and lungs! No weaknesses, just demands for more oxygen.
After listening for a few months I am still amazed by the enjoyable quality of the RM33le. My Naim series 5 gear is very compatible with the speakers and does a fine job however the speakers would clearly reveal any upgrades in the system. I am listening to many different types of music and find all to be well presented and exciting. A woofer on one side was not working after receiving the speakers via a UPS shipment. Jeff Joseph himself guided me by email and telephone and the problem was quickly solved with no reoccurance. Jeff's personal attention to customer service was outstanding.
Similar Products Used:
Audio Note AN-J spe Audio Note AN-K spe
[May 14, 2003]
So transparent it connects directly with your mind. Image size very stable regardless of volume. Excellent dispersion results in wide sweet spot that only gradually tapers. Easy to move around in "sweet zone". Reasonably efficient. Well designed for real world living spaces.
too soon to know. Probably needs real power to fill in lower octaves. Will definitely require you to rethink your recordings and your equipment. Any colorations will make themselves known in short order.
The 33LE is a recent addition to the Joseph line, having arrived on the retail scene only the briefest while ago, with little fanfare. Technically it fills the space between the well established RM33si and the flagship Pearl. However, my limited experience suggests that it is a thing unto itself, and shouldn't be merely thought of as a souped up 33si or a scaled down Pearl. I had the opportunity to hear the 33LE at Bob Visintainer's location at 24th street in Manhattan. Bob is an easy man to get along with, he never imposes himself, as I think he is confident that the goods will speak for themselves more eloquently than any sales pitch ever will. The showroom is of considerable size and liberally treated with damping panels which suggests that deep bass will come off differently than it will in a typical living room, especially in the typical Manhattan apartment. Bob matched up the 33LE with a single-ended amp, the Sophia, using one 845 output tube for 20 watts of power. If you haven't heard the best in SE amplification in the last 3 or 4 years, be prepared for a startle at how far this supposedly archaic technology has progressed. Set up under these conditions, Bob handed me the remote and left me at liberty to play what I was inclined to, with one admonition not to play too loudly during work hours. He has neighbors, a problem all too familiar to New Yorkers. Listening was one hour: Eduardo Eguez' Bach Lute; Glass/uakti Aguas de Amazona; Anner Bylsma, Bach cello suites performed on a Strad cello; and Allman Brothers at Fillmore East, ultradisk gold cd version. The immediate difference between the 33si and the 33LE was "that's a darned good represenation of music" to "this is your brain on music". The mid and the tweeter have been so finely mated that they sound like a single driver that is somewhere between a cone and a ribbon. From around 500 Hz and up, the sound is completely of a piece. I believe that the speaker was so new, and because of Bob's neighbors, the needed extended period of high volume blasting hadn't taken place yet, resulting in a midbass that needs time to open up and fill in. However, the parts of the sound that were coming into focus had a near overwhelming intensity and impulsive power. One often hears about low frequencies having a tactile, impactive sensation against the body. This was the first time in my listening that high frequencies felt like compact punches of air. The most impossibly complex overtones that Uakti music is loaded with, glass gongs, gourd instruments strung with steel wire, things I never dreamed could be reproduced by a cone driver, border on overwhelming. When Bob concluded with Louis' St. James Infirmary, I came close to falling out of my chair. You get Armstrong in a new way when you can hear him like that. At any rate, there is much work to be done. The speakers need a thorough break in, different amps will need to be tried out to find the optimal balance of power and finesse, and position will have to be fine tuned, how far apart, how much off the floor in at all, dgrees of toe in. My intuition is that I have heard only a percentage of what the 33LEs can deliver when ideal.
Similar Products Used:
have tried to listen to as many speakers as possible. Currently have modified Monitor and Sonus Faber. Generally prefer 2 way designs for coherence and simplicity.


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The latest seasonally adjusted figures from the Office for National Statistics shows that the UK trade deficit in the balance of trade in goods in August narrowed from July's £8.2 billion to £7.8 billion.
This will bring some welcome news to the Chancellor, George Osborne, when you consider that the economists' general consensus was that it would rise to £8.8 billion.
Overall, when taking services into account as well the total deficit in trade dropped from July's £2.3 billion to £1.9 billion in August. The surplus in services alone remained unchanged at £5.9 billion.
The £400 million narrowing in the overall deficit was driven by a fall of £600 million in the balance of trade in goods against the other EU countries but offset by an increase of £200 million in the balance of trade in goods with the rest of the world.
Total exports of goods rose in the month by 0.6% (£200 million) to £25.5 billion and total imports fell £200 million to £33.3 billion.
But however you look at these figures it still represents a net flow of money out of the UK. All that has happened is that outflow has reduced slightly and, interestingly, it has been in the trade of goods with the EU that the good news (albeit small) comes from.


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Popularity:#2 of 2 Public Schools in Topsfield#179 of 255 Public Schools in Essex County#1,435 of 2,075 Public Schools in Massachusetts#76,113 in Public Schools
View Address and Phone Number for Proctor Elementary, a Public School, at Main Street, Topsfield MA.
View map of Proctor Elementary, and get driving directions from your location.
Find 6 Public Schools within 4 miles of Proctor Elementary.
Find 2 external resources related to Proctor Elementary.
The Proctor Elementary, located in Topsfield, MA, is a publicly funded school district that educates children in Essex County. Public Schools offer K-12 education at elementary schools, middle schools, and high schools located in Essex County. The Public School system follows Massachusetts state public education policies, accepting all children living within the district boundaries for a tuition-free education.You may contact Public Schools for questions about:
Find Topsfield Public School Enrollment and Educational Attainment (Age 25+). Data Source: U.S. Census Bureau; American Community Survey, 2017 ACS 5-Year Estimates.
|Essex County
|Nursery & Preschool Enrollment
|28 (27.7%)
|6,238 (50.2%)
|Kindergarten Enrollment
|27 (64.3%)
|7,593 (87.9%)
|Elementary School Enrollment (Grades 1-4)
|170 (100.0%)
|33,317 (91.3%)
|Elementary School Enrollment (Grades 5-8)
|312 (88.4%)
|35,432 (89.5%)
|High School Enrollment (Grades 9-12)
|237 (94.4%)
|36,031 (85.1%)
|Essex County
|Less than 9th Grade Education
|10 (0.4%)
|30,081 (5.6%)
|9-12th Grade (No Diploma)
|72 (3.1%)
|26,635 (5.0%)
|High School Graduate (Including Equivalency)
|295 (12.9%)
|135,573 (25.4%)


text: On Mon, 18 Aug 2003, William Tai wrote: > When does hostsp start to support prism3 and > what's the difference between prism2.5 and prism3? Why do you think that Prism 3 is not supported? Can you give the source that led you to this conclusion? I don't have a Prism 3 card, but I believe it should work with the existing code. I remember a report that linux-wlan-ng worked with a Prism 3 card without any changes. As for the differences, look for your self at http://www.intersil.com/cda/application/0,1239,2,00.html Unfortunately, I don't see any side-by-side comparison. You may want to compare specifications of the integrates Baseband/MAC chips - they interact with the driver software. -- Regards, Pavel Roskin


text:
Drug and Alcohol Rehabilitation: Twenty-Four-Hour Ambulatory Blood Pressure Monitoring in Hypertension: An Evidence-Based Analysis.
Twenty-four-hour ambulatory blood pressure monitoring in hypertension: an evidence-based analysis.
Filed under: Drug and Alcohol Rehabilitation
Ont Health Technol Assess Ser. 2012; 12(15): 1-65
The objective of this health technology assessment was to determine the clinical effectiveness and cost-effectiveness of 24-hour ambulatory blood pressure monitoring (ABPM) for hypertension. CLINICAL NEED: CONDITION AND TARGET POPULATION Hypertension occurs when either systolic blood pressure, the pressure in the artery when the heart contracts, or diastolic blood pressure, the pressure in the artery when the heart relaxes between beats, are consistently high. Blood pressure (BP) that is consistently more than 140/90 mmHg (systolic/diastolic) is considered high. A lower threshold, greater than 130/80 mmHg (systolic/diastolic), is set for individuals with diabetes or chronic kidney disease. In 2006 and 2007, the age-standardized incidence rate of diagnosed hypertension in Canada was 25.8 per 1,000 (450,000 individuals were newly diagnosed). During the same time period, 22.7% of adult Canadians were living with diagnosed hypertension. A smaller proportion of Canadians are unaware they have hypertension; therefore, the estimated number of Canadians affected by this disease may be higher. Diagnosis and management of hypertension are important, since elevated BP levels are related to the risk of cardiovascular disease, including stroke. In Canada in 2003, the costs to the health care system related to the diagnosis, treatment, and management of hypertension were over $ 2.3 billion (Cdn). TECHNOLOGY: The 24-hour ABPM device consists of a standard inflatable cuff attached to a small computer weighing about 500 grams, which is worn over the shoulder or on a belt. The technology is noninvasive and fully automated. The device takes BP measurements every 15 to 30 minutes over a 24-to 28-hour time period, thus providing extended, continuous BP recordings even during a patient's normal daily activities. Information on the multiple BP measurements can be downloaded to a computer. The main detection methods used by the device are auscultation and oscillometry. The device avoids some of the pitfalls of conventional office or clinic blood pressure monitoring (CBPM) using a cuff and mercury sphygmomanometer such as observer bias (the phenomenon of measurement error when the observer overemphasizes expected results) and white coat hypertension (the phenomenon of elevated BP when measured in the office or clinic but normal BP when measured outside of the medical setting).Is there a difference in patient outcome and treatment protocol using 24-hour ABPM versus CBPM for uncomplicated hypertension?Is there a difference between the 2 technologies when white coat hypertension is taken into account?What is the cost-effectiveness and budget impact of 24-hour ABPM versus CBPM for uncomplicated hypertension?A literature search was performed on August 4, 2011 using OVID MEDLINE, MEDLINE In-Process and Other Non-Indexed Citations, EMBASE, the Cumulative Index to Nursing and Allied Health Literature (CINAHL), the Cochrane Library, and the International Agency for Health Technology Assessment (INAHTA) for studies published from January 1, 1997 to August 4, 2011. Abstracts were reviewed by a single reviewer. For those studies meeting the eligibility criteria, full-text articles were obtained. Reference lists were also examined for any additional relevant studies not identified through the search. Articles with unknown eligibility were reviewed with a second clinical epidemiologist and then a group of epidemiologists until consensus was established. The quality of evidence was assessed as high, moderate, low, or very low according to GRADE methodology.English language articles;published between January 1, 1997 and August 4, 2011;adults aged 18 years of age or older;journal articles reporting on the effectiveness, cost-effectiveness, or safety for the comparison of interest;clearly described study design and methods;health technology assessments, systematic reviews, meta-analyses, or randomized controlled trials.non-English papers;animal or in vitro studies;case reports, case series, or case-case studies;studies comparing different antihypertensive therapies and evaluating their antihypertensive effects using 24-hour ABPM;studies on home or self-monitoring of BP, and studies on automated office BP measurement;studies in high-risk subgroups (e.g. diabetes, pregnancy, kidney disease). OUTCOMES OF INTEREST: PATIENT OUTCOMES: MORTALITY: all cardiovascular events (e.g., myocardial infarction [MI], stroke);non-fatal: all cardiovascular events (e.g., MI, stroke);combined fatal and non-fatal: all cardiovascular events (e.g., MI, stroke);all non-cardiovascular events;control of BP (e.g. systolic and/or diastolic target level). DRUG-RELATED OUTCOMES: percentage of patients who show a reduction in, or stop, drug treatment;percentage of patients who begin multi-drug treatment;drug therapy use (e.g. number, intensity of drug use);drug-related adverse events.The quality of the body of evidence was assessed as high, moderate, low, or very low according to the GRADE Working Group criteria. As stated by the GRADE Working Group, the following definitions of quality were used in grading the quality of the evidence: HighFurther research is very unlikely to change confidence in the estimate of effect.ModerateFurther research is likely to have an important impact on confidence in the estimate of effect and may change the estimate.LowFurther research is very likely to have an important impact on confidence in the estimate of effect and is likely to change the estimate.Very LowAny estimate of effect is very uncertain.SHORT-TERM FOLLOW-UP STUDIES (LENGTH OF FOLLOW-UP OF #ENTITYSTARTX02264; 1 YEAR): Based on very low quality of evidence, there is no difference between technologies for non-fatal cardiovascular events.Based on moderate quality of evidence, ABPM resulted in improved BP control among patients with sustained hypertension compared to CBPM.Based on low quality of evidence, ABPM resulted in hypertensive patients being more likely to stop antihypertensive therapy and less likely to proceed to multi-drug therapy compared to CBPM.Based on low quality of evidence, there is a beneficial effect of ABPM on the intensity of antihypertensive drug use compared to CBPM.Based on moderate quality of evidence, there is no difference between technologies in the number of antihypertensive drugs used.Based on low to very low quality of evidence, there is no difference between technologies in the risk for a drug-related adverse event or noncardiovascular event. LONG-TERM FOLLOW-UP STUDY (MEAN LENGTH OF FOLLOW-UP OF 5 YEARS): Based on moderate quality of evidence, there is a beneficial effect of ABPM on total combined cardiovascular events compared to CBPM.Based on low quality of evidence, there is a lack of a beneficial effect of ABPM on nonfatal cardiovascular events compared to CBPM; however, the lack of a beneficial effect is based on a borderline result.Based on low quality of evidence, there is no beneficial effect of ABPM on fatal cardiovascular events compared to CBPM.Based on low quality of evidence, there is no difference between technologies for the number of patients who began multi-drug therapy.Based on low quality of evidence, there is a beneficial effect of CBPM on control of BP compared to ABPM. This result is in the opposite direction than expected.Based on moderate quality of evidence, there is no difference between technologies in the risk for a drug-related adverse event.
HubMed – drug
Cost-Effectiveness of Interventions for Chronic Obstructive Pulmonary Disease (COPD) Using an Ontario Policy Model.
Filed under: Drug and Alcohol Rehabilitation
Ont Health Technol Assess Ser. 2012; 12(12): 1-61
Chandra K, Blackhouse G, McCurdy B, Bornstein M, Campbell K, Costa V, Franek J, Kaulback K, Levin L, Sehatzadeh S, Sikich N, Thabane M, Goeree R
In July 2010, the Medical Advisory Secretariat (MAS) began work on a Chronic Obstructive Pulmonary Disease (COPD) evidentiary framework, an evidence-based review of the literature surrounding treatment strategies for patients with COPD. This project emerged from a request by the Health System Strategy Division of the Ministry of Health and Long-Term Care that MAS provide them with an evidentiary platform on the effectiveness and cost-effectiveness of COPD interventions.AFTER AN INITIAL REVIEW OF HEALTH TECHNOLOGY ASSESSMENTS AND SYSTEMATIC REVIEWS OF COPD LITERATURE, AND CONSULTATION WITH EXPERTS, MAS IDENTIFIED THE FOLLOWING TOPICS FOR ANALYSIS: vaccinations (influenza and pneumococcal), smoking cessation, multidisciplinary care, pulmonary rehabilitation, long-term oxygen therapy, noninvasive positive pressure ventilation for acute and chronic respiratory failure, hospital-at-home for acute exacerbations of COPD, and telehealth (including telemonitoring and telephone support). Evidence-based analyses were prepared for each of these topics. For each technology, an economic analysis was also completed where appropriate. In addition, a review of the qualitative literature on patient, caregiver, and provider perspectives on living and dying with COPD was conducted, as were reviews of the qualitative literature on each of the technologies included in these analyses.The Chronic Obstructive Pulmonary Disease Mega-Analysis series is made up of the following reports, which can be publicly accessed at the MAS website at: http://www.hqontario.ca/en/mas/mas_ohtas_mn.html.Chronic Obstructive Pulmonary Disease (COPD) Evidentiary FrameworkInfluenza and Pneumococcal Vaccinations for Patients With Chronic Obstructive Pulmonary Disease (COPD): An Evidence-Based AnalysisSmoking Cessation for Patients With Chronic Obstructive Pulmonary Disease (COPD): An Evidence-Based AnalysisCommunity-Based Multidisciplinary Care for Patients With Stable Chronic Obstructive Pulmonary Disease (COPD): An Evidence-Based AnalysisPulmonary Rehabilitation for Patients With Chronic Obstructive Pulmonary Disease (COPD): An Evidence-Based AnalysisLong-Term Oxygen Therapy for Patients With Chronic Obstructive Pulmonary Disease (COPD): An Evidence-Based AnalysisNoninvasive Positive Pressure Ventilation for Acute Respiratory Failure Patients With Chronic Obstructive Pulmonary Disease (COPD): An Evidence-Based AnalysisNoninvasive Positive Pressure Ventilation for Chronic Respiratory Failure Patients With Stable Chronic Obstructive Pulmonary Disease (COPD): An Evidence-Based AnalysisHospital-at-Home Programs for Patients With Acute Exacerbations of Chronic Obstructive Pulmonary Disease (COPD): An Evidence-Based AnalysisHome Telehealth for Patients With Chronic Obstructive Pulmonary Disease (COPD): An Evidence-Based AnalysisCost-Effectiveness of Interventions for Chronic Obstructive Pulmonary Disease Using an Ontario Policy ModelEXPERIENCES OF LIVING AND DYING WITH COPD: A Systematic Review and Synthesis of the Qualitative Empirical LiteratureFOR MORE INFORMATION ON THE QUALITATIVE REVIEW, PLEASE CONTACT MITA GIACOMINI AT: http://fhs.mcmaster.ca/ceb/faculty_member_giacomini.htm.FOR MORE INFORMATION ON THE ECONOMIC ANALYSIS, PLEASE VISIT THE PATH WEBSITE: http://www.path-hta.ca/About-Us/Contact-Us.aspx.The Toronto Health Economics and Technology Assessment (THETA) collaborative has produced an associated report on patient preference for mechanical ventilation. For more information, please visit the THETA website: http://theta.utoronto.ca/static/contact.Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation throughout the airways, parenchyma, and pulmonary vasculature. The inflammation causes repeated cycles of injury and repair in the airway wall- inflammatory cells release a variety of chemicals and lead to cellular damage. The inflammation process also contributes to the loss of elastic recoil pressure in the lung, thereby reducing the driving pressure for expiratory flow through narrowed and poorly supported airways, in which airflow resistance is significantly increased. Expiratory flow limitation is the pathophysiological hallmark of COPD. Exacerbations of COPD contribute considerably to morbidity and mortality, and impose a burden on the health care system. They are a leading cause of emergency room visits and hospitalizations, particularly in the winter. In Canada, the reported average cost for treating a moderate exacerbation is $ 641; for a major exacerbation, the cost is $ 10,086.The objective of this study was to evaluate the cost-effectiveness and budget impact of the following interventions in moderate to very severe COPD, investigated in the Medical Advisory Secretariat Chronic Obstructive Pulmonary Disease Mega-Analysis Series: smoking cessation programs in moderate COPD in an outpatient setting:- intensive counselling (IC) versus usual care (UC)- nicotine replacement therapy (NRT) versus UC- IC + NRT versus placebo- bupropion versus placebomultidisciplinary care (MDC) teams versus UC in moderate to severe COPD in an outpatient settingpulmonary rehabilitation (PR) versus UC following acute exacerbations in moderate to severe COPDlong-term oxygen therapy (LTOT) versus UC in severe hypoxemia in COPD in an outpatient settingventilation:- noninvasive positive pressure ventilation (NPPV) + usual medical care versus usual medical care in acute respiratory failure due to an acute exacerbation in severe COPD in an inpatient setting- weaning with NPPV versus weaning with invasive mechanical ventilation in acute respiratory failure due to an acute exacerbation in very severe COPD in an inpatient settingA cost-utility analysis was conducted using a Markov probabilistic model. The model consists of different health states based on the Global Initiative for Chronic Obstructive Lung Disease COPD severity classification. Patients were assigned different costs and utilities depending on their severity health state during each model cycle. In addition to moving between health states, patients were at risk of acute exacerbations of COPD in each model cycle. During each cycle, patients could have no acute exacerbation, a minor acute exacerbation, or a major exacerbation. For the purposes of the model, a major exacerbation was defined as one that required hospitalization. Patients were assigned different costs and utilities in each model cycle, depending on whether they experienced an exacerbation, and its severity. Starting cohorts reflected the various patient populations from the trials analyzed. Incremental cost-effectiveness ratios (ICERs)-that is, costs per quality-adjusted life-year (QALY)-were estimated for each intervention using clinical parameters and summary estimates of relative risks of (re)hospitalization, as well as mortality and abstinence rates, from the COPD mega-analysis evidence-based analyses. A budget impact analysis was also conducted to project incremental costs already being incurred or resources already in use in Ontario. Using provincial data, medical literature, and expert opinion, health system impacts were calculated for the strategies investigated. All costs are reported in Canadian dollars.All smoking cessation programs were dominant (i.e., less expensive and more effective overall). Assuming a base case cost of $ 1,041 and $ 1,527 per patient for MDC and PR, the ICER was calculated to be $ 14,123 per QALY and $ 17,938 per QALY, respectively. When the costs of MDC and PR were varied in a 1-way sensitivity analysis to reflect variation in resource utilization reported in the literature, the ICER increased to $ 55,322 per QALY and $ 56,270 per QALY, respectively. Assuming a base case cost of $ 2,261 per year per patient for LTOT as reported by data from the Ontario provincial program, the ICER was calculated to be $ 38,993 per QALY. Ventilation strategies were dominant (i.e., cheaper and more effective), as reflected by the clinical evidence of significant in-hospital days avoided in the study group. Ontario currently pays for IC through physician billing (translating to a current burden of $ 8 million) and bupropion through the Ontario Drug Benefit program (translating to a current burden of almost $ 2 million). The burden of NRT was projected to be $ 10 million, with future expenditures of up to $ 1 million in Years 1 to 3 for incident cases. Ontario currently pays for some chronic disease management programs. Based on the most recent Family Health Team data, the costs of MDC programs to manage COPD were estimated at $ 85 million in fiscal year 2010, with projected future expenditures of up to $ 51 million for incident cases, assuming the base case cost of the program. However, this estimate does not accurately reflect the current costs to the province because of lack of report by Family Health Teams, lack of capture of programs outside this model of care by any data set in the province, and because the resource utilization and frequency of visits/follow-up phone calls were based on the findings in the literature rather than the actual Family Health Team COPD management programs in place in Ontario. Therefore, MDC resources being utilized in the province are unknown and difficult to measure. Data on COPD-related hospitalizations were pulled from Ontario administrative data sets and based on consultation with experts. Half of hospitalized patients will access PR resources at least once, and half of these will repeat the therapy, translating to a potential burden of $ 17 million to $ 32 million, depending on the cost of the program. These resources are currently being absorbed, but since utilization is not being captured by any data set in the province, it is difficult to quantify and estimate. Provincial programs may be under-resourced, and patients may not be accessing these services effectively. (ABSTRACT TRUNCATED)
HubMed – drug
Internet-based device-assisted remote monitoring of cardiovascular implantable electronic devices: an evidence-based analysis.
Filed under: Drug and Alcohol Rehabilitation
Ont Health Technol Assess Ser. 2012; 12(1): 1-86
Pron G, Ieraci L, Kaulback K,
OBJECTIVE: The objective of this Medical Advisory Secretariat (MAS) report was to conduct a systematic review of the available published evidence on the safety, effectiveness, and cost-effectiveness of Internet-based device-assisted remote monitoring systems (RMSs) for therapeutic cardiac implantable electronic devices (CIEDs) such as pacemakers (PMs), implantable cardioverter-defibrillators (ICDs), and cardiac resynchronization therapy (CRT) devices. The MAS evidence-based review was performed to support public financing decisions. CLINICAL NEED: CONDITION AND TARGET POPULATION Sudden cardiac death (SCD) is a major cause of fatalities in developed countries. In the United States almost half a million people die of SCD annually, resulting in more deaths than stroke, lung cancer, breast cancer, and AIDS combined. In Canada each year more than 40,000 people die from a cardiovascular related cause; approximately half of these deaths are attributable to SCD. Most cases of SCD occur in the general population typically in those without a known history of heart disease. Most SCDs are caused by cardiac arrhythmia, an abnormal heart rhythm caused by malfunctions of the heart's electrical system. Up to half of patients with significant heart failure (HF) also have advanced conduction abnormalities. Cardiac arrhythmias are managed by a variety of drugs, ablative procedures, and therapeutic CIEDs. The range of CIEDs includes pacemakers (PMs), implantable cardioverter-defibrillators (ICDs), and cardiac resynchronization therapy (CRT) devices. Bradycardia is the main indication for PMs and individuals at high risk for SCD are often treated by ICDs. Heart failure (HF) is also a significant health problem and is the most frequent cause of hospitalization in those over 65 years of age. Patients with moderate to severe HF may also have cardiac arrhythmias, although the cause may be related more to heart pump or haemodynamic failure. The presence of HF, however, increases the risk of SCD five-fold, regardless of aetiology. Patients with HF who remain highly symptomatic despite optimal drug therapy are sometimes also treated with CRT devices. With an increasing prevalence of age-related conditions such as chronic HF and the expanding indications for ICD therapy, the rate of ICD placement has been dramatically increasing. The appropriate indications for ICD placement, as well as the rate of ICD placement, are increasingly an issue. In the United States, after the introduction of expanded coverage of ICDs, a national ICD registry was created in 2005 to track these devices. A recent survey based on this national ICD registry reported that 22.5% (25,145) of patients had received a non-evidence based ICD and that these patients experienced significantly higher in-hospital mortality and post-procedural complications. In addition to the increased ICD device placement and the upfront device costs, there is the need for lifelong follow-up or surveillance, placing a significant burden on patients and device clinics. In 2007, over 1.6 million CIEDs were implanted in Europe and the United States, which translates to over 5.5 million patient encounters per year if the recommended follow-up practices are considered. A safe and effective RMS could potentially improve the efficiency of long-term follow-up of patients and their CIEDs. TECHNOLOGY: In addition to being therapeutic devices, CIEDs have extensive diagnostic abilities. All CIEDs can be interrogated and reprogrammed during an in-clinic visit using an inductive programming wand. Remote monitoring would allow patients to transmit information recorded in their devices from the comfort of their own homes. Currently most ICD devices also have the potential to be remotely monitored. Remote monitoring (RM) can be used to check system integrity, to alert on arrhythmic episodes, and to potentially replace in-clinic follow-ups and manage disease remotely. They do not currently have the capability of being reprogrammed remotely, although this feature is being tested in pilot settings. Every RMS is specifically designed by a manufacturer for their cardiac implant devices. For Internet-based device-assisted RMSs, this customization includes details such as web application, multiplatform sensors, custom algorithms, programming information, and types and methods of alerting patients and/or physicians. The addition of peripherals for monitoring weight and pressure or communicating with patients through the onsite communicators also varies by manufacturer. Internet-based device-assisted RMSs for CIEDs are intended to function as a surveillance system rather than an emergency system. Health care providers therefore need to learn each application, and as more than one application may be used at one site, multiple applications may need to be reviewed for alarms. All RMSs deliver system integrity alerting; however, some systems seem to be better geared to fast arrhythmic alerting, whereas other systems appear to be more intended for remote follow-up or supplemental remote disease management. The different RMSs may therefore have different impacts on workflow organization because of their varying frequency of interrogation and methods of alerts. The integration of these proprietary RM web-based registry systems with hospital-based electronic health record systems has so far not been commonly implemented. Currently there are 2 general types of RMSs: those that transmit device diagnostic information automatically and without patient assistance to secure Internet-based registry systems, and those that require patient assistance to transmit information. Both systems employ the use of preprogrammed alerts that are either transmitted automatically or at regular scheduled intervals to patients and/or physicians. The current web applications, programming, and registry systems differ greatly between the manufacturers of transmitting cardiac devices. In Canada there are currently 4 manufacturers-Medtronic Inc., Biotronik, Boston Scientific Corp., and St Jude Medical Inc.-which have regulatory approval for remote transmitting CIEDs. Remote monitoring systems are proprietary to the manufacturer of the implant device. An RMS for one device will not work with another device, and the RMS may not work with all versions of the manufacturer's devices. All Internet-based device-assisted RMSs have common components. The implanted device is equipped with a micro-antenna that communicates with a small external device (at bedside or wearable) commonly known as the transmitter. Transmitters are able to interrogate programmed parameters and diagnostic data stored in the patients' implant device. The information transfer to the communicator can occur at preset time intervals with the participation of the patient (waving a wand over the device) or it can be sent automatically (wirelessly) without their participation. The encrypted data are then uploaded to an Internet-based database on a secure central server. The data processing facilities at the central database, depending on the clinical urgency, can trigger an alert for the physician(s) that can be sent via email, fax, text message, or phone. The details are also posted on the secure website for viewing by the physician (or their delegate) at their convenience. RESEARCH QUESTIONS: The research directions and specific research questions for this evidence review were as follows: To identify the Internet-based device-assisted RMSs available for follow-up of patients with therapeutic CIEDs such as PMs, ICDs, and CRT devices.To identify the potential risks, operational issues, or organizational issues related to Internet-based device-assisted RM for CIEDs.To evaluate the safety, acceptability, and effectiveness of Internet-based device-assisted RMSs for CIEDs such as PMs, ICDs, and CRT devices.To evaluate the safety, effectiveness, and cost-effectiveness of Internet-based device-assisted RMSs for CIEDs compared to usual outpatient in-office monitoring strategies.To evaluate the resource implications or budget impact of RMSs for CIEDs in Ontario, Canada. RESEARCH METHODS: LITERATURE SEARCH: The review included a systematic review of published scientific literature and consultations with experts and manufacturers of all 4 approved RMSs for CIEDs in Canada. Information on CIED cardiac implant clinics was also obtained from Provincial Programs, a division within the Ministry of Health and Long-Term Care with a mandate for cardiac implant specialty care. Various administrative databases and registries were used to outline the current clinical follow-up burden of CIEDs in Ontario. The provincial population-based ICD database developed and maintained by the Institute for Clinical Evaluative Sciences (ICES) was used to review the current follow-up practices with Ontario patients implanted with ICD devices. SEARCH STRATEGY: A literature search was performed on September 21, 2010 using OVID MEDLINE, MEDLINE In-Process and Other Non-Indexed Citations, EMBASE, the Cumulative Index to Nursing & Allied Health Literature (CINAHL), the Cochrane Library, and the International Agency for Health Technology Assessment (INAHTA) for studies published from 1950 to September 2010. Search alerts were generated and reviewed for additional relevant literature until December 31, 2010. Abstracts were reviewed by a single reviewer and, for those studies meeting the eligibility criteria full-text articles were obtained. Reference lists were also examined for any additional relevant studies not identified through the search. (ABSTRACT TRUNCATED)
HubMed – drug
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Preached by Rob Sturdy on Oct 30, 2011
Archive for October, 2011
Jonah 1.17-2.10Posted: October 31, 2011 by limabean03 in Uncategorized
Jonah 1.1-16Posted: October 31, 2011 by limabean03 in Uncategorized
Preached by Bruce Geary on Oct 23, 2011
Theses #62 by M. LutherPosted: October 31, 2011 by doulos tou Theou in Christianity, Reformation Theology, Reformed Theology
Starting point for Christian UnityPosted: October 31, 2011 by doulos tou Theou in Christianity, Discipleship, The Christian Life
A helpful little post by Kevin DeYoung in it he quotes Lloyd-Jones:
Martyn Lloyd-Jones, in his address to the Westminster Ministers' Fellowship in June 1962:
The starting point in considering the question of unity must always be regeneration and belief of the truth. Nothing else produces unity, and, as we have seen clearly, it is impossible apart from this.
An appearance or a facade of unity based on anything else, and at the expense of these two criteria, or which ignores them, is clearly a fraud and a lie. People are not one, nor in a state of unity, who disagree about fundamental questions such as:
(a) whether we submit ourselves utterly to revealed truth or rely ultimately upon our reason and human thinking;
(b) the historic fall, and man's present state and condition in sin, under the wrath of God, and in complete helplessness and hopelessness as regards salvation; and
(c) the person of our Lord Jesus Christ and the utter, absolute necessity, and sole sufficiency, of His substitutionary atoning work for sinners.
To give the impression that they are one simply because of a common outward organization is not only to mislead the world which is outside the church but to be guilty of a lie. (Knowing the Times, 160-61).
There is no Gospel where there is free willPosted: October 27, 2011 by doulos tou Theou in Christian Theology, Christianity, Reformed Theology, Uncategorized
A helpful article by Byron Yawn on freedom of the will. Here's a small bit of it, but the whole article is worth your time.
By proposing free will in salvation we may think we are defending the essence of the Gospel, but we are in fact denying it. Most who hold to free will assume they are preserving the quality of love between Savior and sinner, but are in fact diluting it. If you add free will to the equation it actually marginalizes the Gospel. The Gospel was necessary- exactly and specifically – because man did not have the capacity to bring himself to God. Such is God's love. Jesus died because we could not save ourselves in any sense of the word. The Gospel is about a rescue mission and not about lending man a helping hand in his search for God.
To state it completely, it was the absence of freewill (total depravity) which necessitated the incarnation, death, burial and resurrection of Jesus Christ. There is no Gospel where there is free will. He came into the world to save us principally because we lacked the free will to save ourselves, not because we possessed it. We were "dead in our trespasses." Free will does not assist in defending the Gospel it does away with the need for it.
read the whole article here
Debate Audio: "Can God become man?"Posted: October 26, 2011 by doulos tou Theou in Christian Theology, Christianity
Audio of a debate between a reformed apologist and a muslim apologist
"now that you have come to know God, or rather to be known by God" -Gal 4:9Posted: October 26, 2011 by doulos tou Theou in Christian Theology, Christianity, Discipleship, Uncategorized
"We do not make friends with God; God makes friends with us, bringing us to know him by making his love known to us… The word know, when used of God in this way, is a sovereign-grace word, pointing to God's initiative in loving, choosing, redeeming, calling and preserving."
– J. I. Packer


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The US was the favourite hotspot for Chinese buyers, followed by Australia, Canada and New Zealand during Q4 2015, says Juwai.com on Yahoo News (25 April 2016). Other countries that... Lire plus >
The recent seven percent stamp duty increase in Victoria for foreign home buyers will have a negative impact on foreign investment and foreign supply in Australia, reports the Australian (23... Lire plus >
Chinese buyers accounted for A$24 billion out of the total amount of A$96.9 billion worth of Australian real estate bought by foreign buyers in 2014-2015, reports Your Investment Property (13... Lire plus >
Experts from the real estate and investment industries have shown concerns over Chinese buyers facing obstacles in transferring money overseas for investment, reports The Australian (16 April 2016). However, Juwai... Lire plus >
Foreign investors have poured A$1 billion into Tasmanian property in 2014-15, up from merely A$30 million the year before, reports The Mercury (16 April 2016). According to Charles Pittar, CEO... Lire plus >
Chinese enquiries for Canadian real estate surged 134% in the Q1 2016 compared to last year on Juwai.com, reports Bloomberg (14 April 2016). Juwai Data shows that the total value... Lire plus >
Juwai.com has just partnered up with the JRD Group of Dubai to enable more Chinese buyers invest in UAE properties, reports The National (14 April 2016). According to Juwai.com, enquiries... Lire plus >
With the implementation of the new rules on asset management in China, the internal logic and development direction of China's wealth management industry have undergone major changes.
@juwailimited Twitter
Dernières nouvelles et analyses des tendances des acheteurs fonciers chinois.
Wuhan set to lift draconian restrictions in force for over two months, ending lockdown, as China gets people back to work On 24 March, China's Hubei province announced it will allow transportation...Lire plus >
China is a country rich with heritage and uses colours symbolically within every ceremony, festival, and ritual. Even at home, Chinese believe the use of colours that follow principles of feng shui can create...Lire plus >
Chinese buyers are now the fastest growing segment of real estate buyers globally as they seek out destinations that offer an attractive way of life, immigrant investment and educational opportunities. However, cross-border...Lire plus >
Malaysia is ticking all the right boxes for Chinese real estate buyers who have reacted to uncertainty and risk by investing in markets that are closer, require less capital, and offer better...Lire plus >


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Namakarana (Sanskrit: नामकरण, Nāmakaraṇa) is the naming ceremony in Hinduism and the fifth of the 16 saṃskāras performed by the Hindus to name the child. According to the Grhya Sutras, it should be performed on the tenth or the twelfth day after birth. But opinions of the later authorities range from the tenth day to the first day of the second year.
The Namkaran puja is either held at home or in a temple where the priest offers prayers to all the gods and to the Agni, the elements, and the spirits of the forefathers, and entreats them to bless and protect the child. The child`s horoscope if written is also placed in front of the image of the deity for blessings.
If the naming ceremony is not done on the 12th day, it can be done on the 101 day or on the first birthday. After the ceremony a feast is usually arranged to mark the holy occasion and vegetarian meals are prepared.
The mother is specially honored because she brought the child into the world. All the relatives and the guests who are present bless the child and offer gifts to the child and the parents. The blessings say that the child should grow into being a great person like his renowned forefathers. Though the infant, obviously, does not understand the meaning of the ceremony the parents do; and it helps them to understand the responsibility of bringing up and developing the child into a worthy human being. For others who are present it is a reassuring experience of understanding the dignity and value of human life!


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You stumble upon a random letter on the path. You read it. It affects you deeply, and you wish it could be returned to the person to which it's addressed. Write a story about this encounter.
Today's twist: Approach this post in as few words as possible.
A small rectangle blows before me. The paper is old and worn. Stooping to pick it up I read words old as my grandmother. Words of love dated June 6, 1944, fill the page and my heart. I glance around for the object of the affection and fidelity that may have lost this treasured missive. At first I see no one who fits the part. But there she is, a lady younger than me. Seeing the paper she rushes to me with hands open. Our eyes meet silently she takes it. Hers fill with tears as she tucks it away.
Author's Note: I chose to tell this story in 100 words. The date is a small nod to today's 70th anniversary of D-Day.


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Dingen om te doen in Cleveland
Beste aanbevelingen van locals
Ontdek bezienswaardigheden en verborgen pareltjes aan de hand van locals die de stad als hun broekzak kennen.
"The Rock and Roll Hall of Fame is a museum and hall of fame located in downtown Cleveland, Ohio, on the shore of Lake Erie. The museum documents the history of rock music and the artists, producers, engineers, and other notable figures who have influenced its development."
- Door 113 locals aangeraden
"An incredible selection of food stalls ranging from fresh meats and cheeses to candy! A must visit in Ohio City!"
- Door 148 locals aangeraden
Art Museum
"Museum featuring over 45,000 works covering 6,000 years plus films, music, lectures & a restaurant!"
- Door 124 locals aangeraden
Baseball Stadium
"Catch an Indians game (if in season) and root for the home team! Tickets are always reasonable. "
- Door 57 locals aangeraden
Performing Arts Venue
"Catch a play coming through town at Play House Square! It is a incredible venue. "
- Door 59 locals aangeraden
"This is one of the best micro brewery in the country!!! The food is amazing and tours are available. "
- Door 56 locals aangeraden
Amerikaans restaurant
"our favorite Cleveland restaurant with many Paleo options and a gorgeous outdoor patio!"
- Door 63 locals aangeraden
History Museum
"The Cleveland Museum of Natural History is a natural history museum located approximately five miles east of downtown Cleveland, Ohio in University Circle, a 550-acre concentration of educational, cultural and medical institutions."
- Door 43 locals aangeraden
Basketball Stadium
"Rocket Mortgage FieldHouse is a multi-purpose arena in downtown Cleveland, Ohio. The building is the home of the Cleveland Cavaliers of the National Basketball Association and the Cleveland Monsters of the American Hockey League."
- Door 48 locals aangeraden
"Cleveland Zoo is a great getaway/sightseeing event and is also one of my favorite places to visit here in Cleveland. "
- Door 36 locals aangeraden
"The Cleveland Botanical Garden, located in the University Circle neighborhood of Cleveland, Ohio, in the United States, was founded in 1930 as the Garden Center of Greater Cleveland. It was the first such organization in an American city."
- Door 42 locals aangeraden
" FirstEnergy Stadium is a multi-purpose stadium in Cleveland, Ohio, United States, primarily for American football. It is the home field of the Cleveland Browns of the National Football League (NFL), and serves as a venue for other events such as college and high school football, soccer, and concerts."
- Door 28 locals aangeraden
"Part of Cleveland's "Emerald Necklace" it offers some of the best views of downtown Cleveland from the west side. Features a fishing pier, picnic areas with grills, a playground, and a beach. Don't be surprised to see surfers in full-body suits riding the Lake Erie waves in the winter time (when the lake's not frozen.)"
- Door 47 locals aangeraden
"Jack Cleveland Casino is a casino in downtown Cleveland, Ohio, owned and operated by Jack Entertainment. Gaming venue with slots, table games, live music & several restaurants, including a buffet."
- Door 32 locals aangeraden
"Free since its opening, beautiful and recently updated. My favorite spot in Cleveland, 2nd ranked Museum in the US and still underrated. "
- Door 31 locals aangeraden
"Walk out on the pier to get a good view of the lake. Walk on the beach or grill out at the park. During warmer months they have an open concession stand."
- Door 42 locals aangeraden
Uitstekend beoordeelde ervaringen
"This is one of the best micro brewery in the country!!! The food is amazing and tours are available. "
- Door 56 locals aangeraden
Amerikaans restaurant
"our favorite Cleveland restaurant with many Paleo options and a gorgeous outdoor patio!"
- Door 63 locals aangeraden
"Start with a hot dog. Add whatever you could possibly think of on top. This local spot hosts a lot of events, including storytelling the first Wed of every month (think: The Moth podcast), as well as live music."
- Door 45 locals aangeraden
Nieuw Amerikaans restaurant
"Nighttown is the real deal. It's a real joint where, if you were lucky enough to be there, you could have sat in front of the Count Basie Orchestra so close that the trombone would've bopped you in the nose. Or maybe you saw Freddy Cole, Jane Monheit, John Pizzarelli, Brian Auger, Ann Hampton Callaway, Tommy Tune, Basia, Cyrille Aimee, Esperanza Spaulding, Dick Cavett, Dick Gregory, Eliane Elias, Renee Rosnes, Stevie Wonder or John Legend look you right in the eye as they sang or spoke from just a few feet away. "
- Door 31 locals aangeraden
"Great outdoor patio and bar during the summers. Upscale drink spot in Gordon Square on the west side."
- Door 32 locals aangeraden
Nieuw Amerikaans restaurant
"Amazing brunch and dinner menu. Located in Ohio City near Great Lake Brewery. "
- Door 21 locals aangeraden
" American gastropub with a patio, house beers, a distillery & a menu of creative sandwiches & tacos."
- Door 21 locals aangeraden
Vegetarisch/veganistisch restaurant
"Breakfast, Lunch and Dinner options. Extensive Veggie and Vegan menu plus traditional American offerings. Best milk shakes in Cleveland Heights!"
- Door 30 locals aangeraden


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I am trying to analyze mouse RNA-seq expression data but am getting the following error during cuffmerge:
8:119910359-124345724 Warning: Skipping large bundle
I'm using Ensemble m38.69 (Accession #GCA_000001635.2). It seems that there is a giant gene annotated in that interval, GM20388. I understand that the default bundle size in cufflinks (I'm using v2.0.2) is 3,500,000 so I tried increasing the bundle size using the following command:
--max-bundle-length 8000000
Even with the bundle length increased to 8,000,000 I am still getting the same "Skipping large bundle" error. The entire cufflinks command is shown here:
cufflinks --max-bundle-length 8000000 -u -b Mus_musculus.GRCm38.69.dna.toplevel.fa -p 11 -o cufflinks_out/Sample10831 tophat_out/Sample10831/accepted_hits.bam
Any thoughts as to why I'm still getting the error?
may be increase more, also check this post
Tried increasing to a bundle size of 100,000,000 and then 10,000,000,000. Neither one worked.
did you determine how to fix this error? I got the exact same problem in this genome coordinate.


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Blush Satchel
September 13, 2017
Earrings: BP Necklace: Metier Essentials c/o Tank: Harlowe & Graham Bag: Foley and Corinna c/o Denim: Abercrombie & Fitch (only $35!!) Shoes: Dolce Vita
Hiiiii!! So sorry about missing two posts, I've been in New York for Fashion Week then I came home and have been sick! I will be doing a full recap on my trip and it will be up Friday! Today I'm sharing with you guys a cute casual look and my new bag from Foley and Corinna. I love the blush color. I'm just obsessed with bags in general, they are my weakness. I saw soooooo many cute ones in New York. I'm going to a fun blogger event tomorrow so stay tuned on my instagram stories! xx
Photography: Photo 243
10 comments
This is such great outfit and I really love your bag, the colour is stunningReplyDelete
I love the look and I cannot wait for your recap gorgeous!!! XOReplyDelete
I love the color of this bag!ReplyDelete
I love this pretty bag! The color is gorgeous!ReplyDelete
Obsessing over this bag. it's such a great color and looks like the perfect size!ReplyDelete
I have been a big fan of Foley & Corinna since high school! Love their bags and they last so long!ReplyDelete
I always get sick after traveling too! Hope you're feeling better!!ReplyDelete
How 2 Wear It [] http://how2wearit.com
Love the color of your bag! So cute!ReplyDelete
You look gorgeous and I'm loving that bag! xoReplyDelete
You are a knockout in these photos, lady! Love everything about this look!ReplyDelete
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30 years on FM announce that they have decided to record a modern-day version of their now classic debut album INDISCREET. The band was asked many times to consider re-recording some of these tracks using today's modern technology and recording techniques and giving the songs the sound of FM as it is today.
The band realises what an iconic album this is to so many fans so they have always steered clear of tampering with it too much but whilst in the studio recording the follow-up to HEROES & VILLAINS one night at the end of a session FM decided to put down a backing track to "That Girl" to see how it would sound with the huge sounds they were getting at the time. It gave the song a new dynamic and power that it was not possibleto achieve in the 80's.
Whilst playing it again the following morning FM decided it would be great to hear all these classic songs with this new lease of life. "We are not trying to recreate the original but this is our interpretation played by FM as we are today with the sound of FM 2016" says FM's bass player Merv Goldsworthy.
In addition to the re-recording of the original album, INDISCREET 30 also features seven bonus tracks including brand new song "Running On Empty" and a new recording of "Let Love Be The Leader".
INDISCREET 30 was produced by FM, recorded at Tremolo Studios and Coal House Studios, Staffordshire and mixed by Jeff Knowler (METROPOLIS, ROCKVILLE and HEROES & VILLAINS).
Steve Overland - lead vocals, rhythm guitar
Merv Goldsworthy - bass, backing vocals
Pete Jupp - drums, backing vocals
Jem Davis – keyboards
Jim Kirkpatrick - lead guitar, backing vocals
Indiscreet 30 is released today.
Tracklisting : 1.That girl 2.The other side of midnight 3.Love lies dying 4.I belong to the night 5.American girls 6.Hotwired 7.Face to face 8.Frozen heart 9.Heart of the matter 10.Let love be the leader 11.Running on empty 12.Rainbow´s end 13.Shot in the dark 14.Bad that´s good in you 15.Love and hate 16.That girl (acoustic version)


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We Just Lived Through A Lost Decade (AAPL, VZ, GS)Tuesday, August 17, 2010 - 10:36am | 866
The talk on Wall Street, in academia and among policymakers has centered on whether or not America is entering a Japanese-style, deflationary "Lost Decade." But by many metrics — and for many Americans — this is old news. Take the stock market, for example. For the past generation, many investors...


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Pet Stories
Happy Anniversary, Max!
July 5th, anniversary for Max joining our family…we love him so much! —Holly H.J.
Remy (aka Luna)
Luna is settling in just fine. We've named her Remy (as in Remy Martin cognac)! She likes the cat a lot! And is learning about dog parks. She likes to hang with us in the office. Thanks again and take care. — Lisa D. & Family
Daisy's Forever Family!
Meet Daisy's Forever Family (well, most of them anyway)! Pictured are Evelyn, Tori, Clara, Kelly, and Jack with Daisy. Taffy and Wes will hopefully be included in future family photos!
Laney's New Family
Laney's new family!
Buddy – Livin' the Dream
Buddy is livin' the good life — in Florida and Illinois!


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It has been the source of much grief during the winter, as the periscopes usually fog up so badly that it becomes impossible to see through them. Particularly in the case of smaller asteroids, the primary delay driver will be the diversion process.
Among these are Fermat's conjecture Lagrange's theorem that every integer is the sum of four squares, and the following: Lastly, it is impossible to directly tell what gave a position away from a kinetic strike, but a ground raid is quite obvious. Given the use of 2E on the BMD-2, which was introduced inwe can assume that the BMP-2 upgraded to the 2E stabilizer complex aroundas that was the year when it was modernized for the first time into the BMP-2 obr.
He derived solutions to cubic equations using the intersection of conic sections with circles. But this charge is unfair; Aristotle himself stressed the importance of ovbservation and experimentation, and to be ready to reject old hypotheses and prepare new ones.
Using the commander's override, full control of the horizontal and vertical drives are handed over to the commander, who is then relieved from his regular duties and instead must take over as gunner, while the gunner does his best to take the place of the commander.
The flak towers went in the next, along with communications and sensors. This is because the light intensification tube operates on extremely high voltages to amplify ambient light to visible levels.
Euclid, Eudoxus and Archytas are other candidates for this honor. As a contingency, capabilities for physical inspection of spacecraft and facilities were evaluated. The first carved stone relief map of a Chinese district was sent to the Emperor in BC, and it was so impressive as to scale and detail that all administrators were commissioned to similarly survey and map their districts, until the entire Empire was represented.
Archimedes was a prolific inventor: The radio has a transmitting and receiving range of between 16km to 50km, depending on the antenna used and the type of terrain. The "only if" is easy but the difficult "if" part was finally proved by Lagrange in Heinlein in which the citizens of the Moon bombard the Earth with rocks wrapped in iron containers which are in turn fired from an electromagnetic launch system at Earth-based targets.
Not until the k-rods started falling, and then it was too late to help us. To be frank, the key word here is saturation. In order for a rod to fall straight toward the center of Earth it would need to be launched away from the station with a tangential velocity equal in magnitude and opposite in direction from the orbiting station.
The report estimates that the rod will impact with a force of The term Pythagorean was also adopted by many disciples who lived later; these disciples include Philolaus of Croton, the natural philosopher Empedocles, and several other famous Greeks.
The fact that this hunter-killer feature exists is of huge importance, as the commander is elevated from a simple observer to an active participant.
Although others solved the problem with other techniques, Archytas' solution for cube doubling was astounding because it wasn't achieved in the plane, but involved the intersection of three-dimensional bodies.
None of these seems difficult today, but it does seem remarkable that they were all first achieved by the same man. Eubulides of Miletus was another ancient Greek famous for paradoxes, e.
Its agents run global covert ops The virus hunters. Qin's textbook discusses various algebraic procedures, includes word problems requiring quartic or quintic equations, explains a version of Horner's Method for finding solutions to such equations, includes Heron's Formula for a triangle's area, and introduces the zero symbol and decimal fractions.
The weapon consisted of a modified R missile the RORB that placed a two- to three-megaton warhead into an orbital trajectory over the southern hemisphere in order to evade US early warning radar and possibly ABM systems by flying lower and approaching from the south, using a retrorocket to de-orbit itself.
Today, Egyptian fractions lead to challenging number theory problems with no practical applications, but they may have had practical value for the Egyptians.
To do this, he is provided with a 1PZ-3 high elevation sight, installed not in the rotating cupola but in the turret roof, forward of the cupola. After the section is transformed all calculations are made using the transformed cross section, just as they would be on a beam of one material.
The composite has a considerably higher shear stiffness to weight ratio than an equivalent beam made of only the core material or the face-sheet material. All howling to each other like the gods below. The spiders all marched back into a shuttle and left us alone, then, so we scavenged what we could, tried to stay alive.
Both the spotlight and the PL beamer can switch from active illumination to pulsed illumination, whereby the IR laser beam is modulated and pulsed. Interestingly, Ptolemy wrote that the fixed point in a model of planetary motion was arbitrary, but rejected the Earth spinning on its axis since he thought this would lead to powerful winds.
Please e-mail and tell me! Similarly, when a photon is created emittedit is occasionally useful to imagine that the photon has made a transition out of the vacuum state. The commander has his own hatch, which has an unusual clam shell shape to grant enough space to accommodate the extremely sparse array of periscopes.Scribd is the world's largest social reading and publishing site.
The most commonly used sandwich theory is linear and is an extension of first order beam theory. Linear sandwich theory is of importance for the design and analysis of sandwich panels, The total bending moment in the beam is Fire resistance of composite floor slabs using a model fire test facility.
From tothe factory now known as Kurganmashzavod produced about 14, BMP-2 models of all types. At the peak of production inbetween 1, to 1, units exited factory gates every year - triple the maximum annual rate of production of the M2 Bradley. To make interacting photons, the team shone a weak laser through a cloud of cold rubidium atoms.
Rather than emerging from this cloud separately, the photons. Theory of simple bending (assumptions) Moment of resistance N A y dy dA – Consider a composite beam made of metal cover plates on the top and bottom with a plastic foam core as shown by the cross sectional area of Figure – The design concept of this composite.
A simple scheme for writing Sinhala words with a standard English key board. englsih2sinhala map (e2s map) The sinhala words given at this website in English characters have not yet been systematically converted to this e2s-map format.Download


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A lot is happening in the world of Monster Hunter at the moment. Monster Hunter World Iceborne is being spoken about a lot, and looks brilliant. However, there is no signs of Monster Hunter World hitting the Nintendo Switch any time soon, I've dusted MHGU off and brought it out of the backlog!
Hopefully this will scratch the hunting itch until Dauntless is released on switch!
In this second hunt @Gcubepreacher is carried by some much more skilled hunters!
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nor cal mikePremium Lifetime Member
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nor cal mike started following New here, my experience so far, Christmas Decorations, My Little Filipina is growing up and and 4 others
My Little Filipina is growing up
nor cal mike replied to Jack Peterson's topic in The FilipinaA beautiful young lady Jack and your rightful pride shows in many of your post.
Million Peso Baby is on the way!!
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A week in the Philippines
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New here, my experience so far
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"Add more comment. And fixed a dangling participle" Thanks Tom, another inexpensive device that I will certainly consider. Glad to see you fixed that participle as you never want your participle to simply dangle:)
Yes Tom, the device cost $99 and the additional monitoring is $99 yearly. However you don't have to purchase the additional monitoring. If you send the ekg for additional scrutiny, I believe there is a charge of 9 or 10 bucks. I find the cost minimal compared to the potential for avoiding a problem such as Geff was able to do.
Thanks to all who are sharing their personal experiences and knowledge gained therefrom. This is one of the most beneficial and informative subjects I've read. I would like to add my personal experience in hopes someone may benefit. About 10 years ago during my annual check-up I was found to have mild afib. I was prescribed baby aspirin and thankfully have had no recurring episodes. A couple of years ago I came across a device called "Kardia mobile". This is a 30 second 1line ekg. It only cost $100 and there are additional monitoring services available at additional cost. I use mine 2 or more times daily. I also take a printout to my doctor for my annual checkups. So simple, so convenient and it provides me great peace of mind. I bought mine in the U.S. from amazon. Don't know if this device is useful in an emergency, but for those who have this rather common anomaly this can provide an early warning that might prevent an emergency.
Excellent post regarding an important subject. While I am only minutes away from the best hospital where I live, I am always concerned about evening and holiday staffing. I have seen 2 close friends suffer fatal heart attacks that may have been survivable had emergency care been available more quickly. I am eager to read what members have to offer.
Spam in the Philippines
nor cal mike replied to alicia t's topic in Philippines Related Off TopicsWhen it comes to spam, everyday is fryday.
My heart aches for this child. So sad 😭.
Sad Reality Of Death
nor cal mike replied to Jollygoodfellow's topic in CultureI've never seen a happier face on someone when we gave him the finished product. AK, you have certainly gained my respect and admiration. Don't stop being you.
Scammed man contact media!
nor cal mike replied to Viking's topic in Scams to be aware of in the PhilippinesRemember guys, "no free lunches" :)
Ponzi schemes shut down.
nor cal mike replied to sonjack2847's topic in Scams to be aware of in the PhilippinesYes I am although I didn't know this was one of his. Thanks for that bit of information.