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In a Perspectives article of 1985 in Cancer Research, I discussed evidence for a nonmutational origin of teratocarcinoma, and cited related claims in liver carcinogenesis, which I later broadened to include spontaneous transformation in cell culture. Further research on spontaneous transformation cast doubt on that interpretation, and motivated re-examination of the cases for teratocarcinomas and liver cancer. This re-examination led to the conclusion that mutation and selection underlie the development of neoplasia in all three cases. At the same time, it affirmed the primary role of hierarchical tissue structure and intercellular relations in maintaining homeostasis, which was the major theme of the 1985 article. Tumor promotion disrupts intercellular relations to allow progressively selective proliferation of initiated cells and accompanying clonal accumulation of genetic change. [Cancer Res 2009;69(6):2171–5]
- neoplastic development
- oncogenic mutation
- physiologic adaptation
In 1984, Peter Magee, the Editor of Cancer Research, asked me to write a Perspectives article on the cell biology of cancer. I wrote about hierarchical relations between cells and how disruption of those relations might result in neoplastic development. The resulting article ( 1) considered as a prime example of such relations the experimental induction of teratocarcinoma by the transplantation of early mouse embryos to the testis of adult mice ( 2), and the totipotent normalizing effect of cells from a euploid teratocarcinoma into the blastocyst of the developing embryo ( 3). The latter result, in particular, led to the conclusion of a nonmutational origin of the teratocarcinoma ( 3). A similar interpretation was cited for chemical carcinogenesis of the liver in an addendum to my article. More detailed support for this interpretation of liver carcinogenesis appeared in a 1991 Perspectives article, to which I contributed a section on spontaneous transformation in cell culture again suggesting a nonmutational origin of transformation ( 4). However, as more information became available and the data were more critically analyzed, it became apparent that the neoplastic transformation and its reversion in the three cases cited were more correctly described as special cases of genetic change and selection. At the same time, the results provided insights on hierarchical relations in tissues, which help to resolve the clonal and field theories of carcinogenesis.
Evidence Linked to a Nonmutational Origin of Cancer
Teratocarcinoma. The strongest case for a nonmutational origin of cancer in the 1985 article came from the transplantation of a small number of embryonal cancer cells from a euploid line of teratocarcinoma cells into the blastocyst of a genetically distinct strain of mice, and after development of the embryos to term ( 3). A few of the mice that developed from the injected blastocysts were genetic mosaics with substantial contributions of tumor-derived cells in many developmentally unrelated tissues, including the germline that formed reproductively functional spermatozoa. The results were interpreted as "an unequivocal example of a nonmutational basis for transformation to malignancy and reversal to normalcy." The origin of the teratocarcinoma from disorganized embryonic cells that had been transplanted to adult testis suggested that "malignancies of some other more specialized stem cells might arise comparably through tissue disorganization leading to developmental aberrations rather than changes in gene structure" ( 3).
Aneuploid sublines of the same teratocarcinoma lost their multipotentiality ( 5, 6). Another line of embryonal cancer cells that maintained its euploid karyotype maintained its multipotentiality ( 7). However, euploid embryonal cancer cells of different origin failed to develop beyond colonization of the yolk sac ( 8). Neither a high rate of colonization nor a normal karyotype ensures full reversion of embryonal cancer cells to normal behavior ( 9). It was conjectured that the normal karyotype of the cases that failed to develop fully could have masked genetic changes below the resolution of karyotyping ( 7). An opportunity to distinguish between reversible epigenetic-physiologic changes and mutation selection in the origin of teratocarcinomas was afforded by the development of the nuclear transfer technique to enucleated oocytes, which can reset the developmental state of the injected nucleus to that of the zygote.
The technique was applied to embryonal cancer nuclei from three teratocarcinomas that differed in their carcinogenicity and differentiative potential ( 10). Fresh teratocarcinomas were obtained by the injection of nuclear transfer embryonic stem cells from the three lines s.c. into mice. Embryonal cancer cells of each line and their respective nuclear transfer embryonic stem cells displayed exactly the same potential when tested for tumor formation and chimera development. Comparative genome hybridization identified the same genetic lesions in the embryonal cancer and nuclear transfer embryonic stem cells of each line, with the number of such lesions inversely proportional to the differentiative potential of each of the three lines. Although it could not be concluded that those lesions were directly responsible for the differing behavior of the cell lines, they were consistent with the idea that genetic changes that could not be reprogrammed determine the developmental potential of each line. Other results show that tumors of known genetic origin besides teratocarcinomas can produce a variety of normal differentiated cells that retain the genetic changes associated with tumorigenesis ( 11). It is noteworthy, however, that the nuclei of leukemia, lymphoma, and breast cancer cells failed to produce embryonic stem cells.
Liver cancer. Evidence for a nonmutational origin of experimental liver cancer was briefly cited in the addendum to my 1985 article ( 1). Liver cancer arises from hepatocyte nodules that are induced by chemical carcinogens ( 12). However, 95% of the nodules are remodeled into normal-appearing liver by a process thought to be redifferentiation ( 13). Farber thought of "the hepatocyte nodule as a physiological response to environmental perturbations… and not as aberration or a mutation" ( 1, 14). The nodules remodeled to the point that they could no longer be grossly distinguished from normal liver. The 5% of nodules that persisted were uniformly stained, kept the 2-cell-thick plates, and were precursors of hepatocarcinomas ( 15).
The remodeled nodules were considered redifferentiated, therefore essentially normal. Remodeling of the hepatocyte nodules was the linchpin of "the most telling evidence that points overwhelmingly to the physiological adaptive nature of the hepatocyte nodule" ( 4). However, the nodules arise from resistant hepatocytes that first form irreversibly altered microscopic foci that are promoted to nodules ( 16). The remodeled nodules exhibit the irregular, patchy staining for nodule-associated enzymes that is characteristic of unpromoted microscopic foci for at least 36 weeks ( 16). At 28 weeks, the remodeled nodules proliferate at one-fourth the rate of persistent nodules, but that is 4 times higher than normal hepatocytes ( 15). They are therefore clearly abnormal in several respects, which is consistent with their mutational origin; so is the one-hit nature of the dose response of hepatocyte focus formation to carcinogen application ( 17). Beginning at 6 months, nodules of characteristically malignant cells appear in a few of the persistent nodules ( 18), indicative of further mutations that drive progression to malignancy.
Farber himself frequently calls attention to similarities in the pathogenesis of liver and skin carcinogenesis, emphasizing the disappearance of nodules in the former and papillomas in the latter as examples of reversibility ( 14, 19). However, the incompleteness of reversion of papilloma is well-established, as is their mutational origin. Labeled papillomas that have fully regressed after cessation of repeated carcinogen treatment of rabbit skin recur when the carcinogen treatment is repeated, or promoting treatment is instituted ( 20). Papillomas of mouse skin that regress after cessation of promotional treatment of initiated skin appear as papillomas much faster than they do in initiated but previously nonpromoted skin when promoter is applied ( 21). The evidence for persistence of remodeled nodules and regressed papillomas is therefore consistent with their mutational origin.
Spontaneous Transformation of Cultured Cells
I wrote the second half of the 1991 Perspectives article in which I supported a physiologically adaptive origin for the neoplastic transformation of cells in culture ( 4). I was influenced by the arguments for a nonmutagenic initiation of teratocarcinomas and liver cancer described above. At that time, my laboratory had begun working on spontaneous transformation of NIH 3T3 cells ( 22), an aneuploid line of mouse fibroblasts that had come into prominence as the most responsive target for transformation by transfection of DNA from a line of cells derived from a human bladder cancer ( 23). Even without transfection, however, the NIH 3T3 cells spontaneously produced a few transformed foci when incubated to confluence ( 24, 25). Because spontaneous transformation was driven by reducing the growth rate of cells, either by confluence or low-density passage in low calf serum (CS), the possibility of classic point mutation as the causal agency seemed remote, and the idea of nonmutational physiologic adaptation became even more attractive than before.
The nature of spontaneous transformation was further explored by isolating cells from transformed foci and subculturing them in low-density passages with high CS to determine whether the transformation was reversible ( 26). The retrieval of the transformed cells was carried out by trypsinizing the foci that were set off from surrounding cells by a cloning cylinder. Repeated low-density passage of the isolated cells in high CS resulted in the apparent reversal of their transformed state. Further support for the physiologic adaptation model was sought in an experiment in which multiple cell lineages were prepared for a single round of confluence in either low or high CS ( 27). Each lineage was then separately cultured through further rounds of confluence in the low CS to determine the variance within each category for saturation density and transformed focus formation. There was no variation in the early increases in saturation density of lineages within each category without foci ( Fig. 1 ), which conformed to the physiologic adaptation model. However, the appearance of dense transformed foci in later rounds of confluence, originating from the first round in high CS for an extended period, showed a wide range of variation ( Fig. 2 ) consistent with a mutational origin. The overall results seemed to be consistent with Farber's view that the multiple early foci and nodules in liver carcinogenesis are physiologically adaptive in origin, but the later rare carcinomas are mutational ( 4).
The physiologic adaptation model began to unravel with the finding that the spontaneously transformed cells derived from foci in confluent cultures proliferated at a lower rate than nontransformed cells in low-density passages with high CS ( 28). This difference in growth rate raised the possibility that any normal cells included during the retrieval of cells from transformed foci would be selected in the subsequent low-density passages, and give the false impression of the reversal of the transformed state. Indeed, when nontransformed cells were excluded by isolation of single transformed cells on glass chips, the transformed state of their progeny proved to be irreversible and, therefore, characteristic of a genetic origin ( 29).
The final tipping point in the realization that even the early increases in saturation density were of genetic origin came from a more careful re-examination of the cultures in Fig. 2. What had been taken as smooth monolayers in the secondary assays in the lower left quadrant of the photograph actually consisted of many uniformly distributed, barely visible small foci. It was then realized that a selection had been made of cells in the first round of confluence with a capacity for proliferation at high density. If there were too many such selected cells, as in the third round of confluence, they formed a thicker but smooth sheet and, in the fourth round, led to further variant selection to produce the fully transformed dense foci seen in the lower right quadrant of Fig. 2 ( 30). The implication is that both the increases in saturation density without foci and the later appearance of foci arise by selection of genetic variants.
Given that the uniform, within-category increases in saturation density resulted from selection, there must have been a relatively high frequency in the starting material of genetic variants for capacity of cells to grow at high density. A high frequency source of such variants is provided by heterogeneity in capacity for development of transformed foci seen in Fig. 3 ( 31). A contribution to such frequent genetic variation is likely to be the chromosomal rearrangements and aneuploidy that were distinctive and unique for each of the NIH 3T3 cells that were examined karyotypically ( 32).
Cell-Cell Contact Interactions Conditionally Determine Suppression or Selection of the Neoplastic Phenotype
Re-examination of the experimental teratocarcinoma literature unearthed the early insight of Damjanóv and Solter ( 33) that the disorganization of mouse embryos transplanted to extrauterine sites in adults allows uncontrolled proliferation of embryonic stem cells, which then undergo a mutation-selection process resulting in teratocarcinomas. The authors suggested that "the clonal theory of cancer…should at least be supplemented with the field theory that emphasizes the intercellular relations as the crucial ones." Although this insight was largely forgotten in the excitement generated by the totipotency of a single subline of euploid teratocarcinoma cells shown a year later ( 3), that very demonstration should have highlighted the importance of intercellular relations in maintaining (and restoring) tissue homeostasis.
A largely forgotten illustration of the normalizing influence of hierarchical structure came from studies of mouse prostate in organ culture ( 34). Treatment of organotypic fragments of prostate with carcinogen produced histologic effects compatible with malignancy, including massive hyperplasia, anaplasia, abnormal mitoses, and invasion through the basement membrane. However, implantations of 872 of the transformed pieces into as many mice under a variety of conditions for extended periods of time failed to produce a single tumor. Indeed, all the implanted pieces recovered from the mice were highly differentiated, and resembled normal prostate. In contrast, disaggregation of cells from the carcinogen-treated prostate and their repeated passage in monolayer culture resulted in their multistep development into permanent cell lines that produced progressively growing transplantable tumors in mice ( 35).
A recent example of the transformation-suppressing role of tissue organization was seen in organotypic culture of mammary acinar structures ( 36). Activation of an oncogene in structurally unorganized acinar structures leads to their hyperproliferation and transformation. However, oncogene activation in mature, quiescent acini with established epithelial architecture does not reinitiate the cell cycle or transform these structures. The capacity of oncogene activation to reinitiate cell proliferation is restored by the loss of a cell polarity regulator protein. Such results may explain the estimate that the probability per cell cycle of carcinogen treatment in vivo giving rise to a tumor is many orders of magnitude lower than that observed for transformation of cells in monolayer culture ( 37).
Other examples of the normalizing effect of cell-cell interactions were given in my 1985 Perspectives article, but oddly enough, the most widely studied of such interactions were unintentionally omitted. "Oddly" because I had reported the first of these in the normalization of chicken fibroblasts transformed by infection with Rous sarcoma virus when seeded on a contact-inhibited monolayer of normal fibroblasts ( 38). There were other studies of such normalizing effects among fibroblasts ( 39), but the full significance of these observations was not appreciated until it was shown that normal epidermal cells suppress the growth of adjacent papilloma cells in culture ( 40) and in skin grafts on mice ( 41). Those findings of cell-cell contact suppression of potentially neoplastic cells provided a physical basis for the failure of carcinogen-initiated epidermal cells to produce tumors for the lifetime of the mouse unless treated repeatedly with a promoting agent ( 42, 43).
A particularly significant aspect of cell-cell interactions was discovered with the introduction of rat hepatocarcinoma cells into the normal liver of rats. Moderately malignant hepatocarcinoma cells injected into the liver of young rats differentiated into mature hepatocytes and failed to proliferate until the rat aged ( 44). Proliferation also occurred when the hepatocarcinoma cells were initially injected into aged rats. The normalization of the hepatocarcinoma cells was most effective when they were introduced into the liver as single cells, which allowed maximum surface contact with the surrounding hepatocytes ( 45). S.c. injection of the hepatocarcinoma cells allowed their maximal proliferation into malignant tumors ( 44). The increase in their proliferation in the liver with age of the recipient rats suggests that a decline in the normalizing capacity of tissue parenchyma contributes to the marked increase of solid epithelial cancers with age ( 46).
1. Reconsideration of the case for a nonmutational, physiologically adaptive origin of teratocarcinoma, hepatocarcinoma, and spontaneous transformation of cells in culture ( 1, 4) supports a process of mutation and selection as their underlying mechanism.
2. The postulated role of hierarchical structure of tissue in suppressing tumor development is reinforced. The primary mode of the suppression is adhesive contact between incipient neoplastic cells and their surrounding normal, homotypic cells. The teratocarcinogenic effect of disorganizing embryos ( 33) counsels caution in the use of disaggregated embryonic stem cells in regenerating normal function in defective adult tissue ( 47). The role of tissue organization in maintaining homeostasis is formalized in the biological principle of ordered heterogeneity, in which there can be regularity in the large where there is heterogeneity in the small ( 48).
3. The effectiveness of the NIH 3T3 cell line as a target for demonstrating the transforming capacity of oncogenes ( 23) depends on its partially transformed state, which needs only a nudge from an added oncogene to progress to more advanced transformation ( 24, 25).
4. Promotion allows selective clonal expansion of mutated cells with increased capacity for proliferation under physiologically inhibitory conditions. That expansion permits further mutations to accumulate. This enrichment step, rather than the initial mutation, is the crucial, numerically limiting factor in tumor development.
Disclosure of Potential Conflicts of Interest
No potential conflicts of interest were disclosed.
The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
I thank Dorothy M. Rubin for editing the manuscript and Drs. Richmond Prehn, Ralph Grundel, Douglas Brash, and George Klein for helpful suggestions for improving the manuscript.
- Received November 4, 2008.
- Revision received January 7, 2009.
- Accepted January 20, 2009.
- ©2009 American Association for Cancer Research.


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Website Designing services provides designing and development services in Orpington area of London. We are based in London and cover Orpington region and operates from our local office based in Greater London. We provide the following development and designing services in Orpington
We can offer you cheap website design services in Orpington. We provide freelance website designing and development services in Orpington region. We can provide you with a free consultation in Orpington on anything related with designing and development.

subset: commoncrawl


text:
Bike hire and -service, shop
in the center of Flachau next to the tourism office
Open from 27th May 2019 to 21st September 2019 from Monday - Fridayfrom 9 am to noon and 3 pm to 6 pm (closed on the 30th May and 10th and 20th June 20019)
Dorfstraße 130, 5542 Flachau
Info Hotline 0043 6457 33913
In July and August we are also open Sundays and Saturdays
Flachau is 70 km in the south of Salzburg. Go on the motorway (A10 Tauernautobahn) and leave at EXIT 66. After the exit you come to a roundabout – take the third exit and go direction center. After about 200 meters turn right. There is a tourism information sign and a parking space. Please leave your car there and follow the way across the field to the Zorb-site.
ATTENTION BY USING A NAVAGATION SYSTEM please do not put in our adress. You cannot park directly at the Zorbing site! The coordinates are: N 47°21'35.989" E 13°23'21.626"
Opening hours
from 1st June 2019 to 21st September 2019
Wednesday and Saturday from 10 am
Fridays from 2 pm
Infohotline: 0043 6457 33913


text:
V12 Telecom provide voice, data and mobile services to IT support companies in the UK. The A5 4pp booklet was sent out to business owners with a £3m+ turnover and needed to appeal to that market. We organised a database of names to add to the covers of the booklets to add a personal touch.
For more information on this project please contact me


text:
We use cookies to help improve your experience on our site. By continuing, we'll assume you are happy to receive all cookies from our website.
Visit our Cookie Policy for more information on the cookies we use and how to manage or remove them.
Pre-Mixed Flavour Boxes Available To Shop Across The Product Range For Delivery Direct To Your Door.
© Copyright 2020.
Blackfriars Bakery 185 Gloucester Crescent Wigston Leicester LE18 4YH


text:
BATTLE CREEK ENQUIRER / SEARCH: 7842 W M-68 , Unit C-5 Indian River, MI 49749
- 2 beds
- 1 baths
- $239,000 price
- 317817 mls id
- Square Feet: 1,160 sqft
- Year Built: 1989
The magnificent views of Burt Lake from this updated, ground floor condominium are unparalleled. Enjoy the benefits of maintenance-free lakefront living in this remodeled unit on Burt Lakes south shore. Offering a beautiful sand swimming area, community dock, two bedroom, 1 3/4 baths, fireplace, covered waterside screened porch and private garage. The remodeled interior and exterior make this a move-in ready showcase unit.
- Site Link
- Style Other Style
Courtesy of: Coldwell Banker Schmidt, Realtors
Office Phone: +12312389336
Listing Agent: Billy Andrew
Updated: 6th April, 2020 12:48 PM.
7842 W M-68 , Unit C-5 Indian River, MI
Real Estate | Battle Creek Enquirer Powered by Placester


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Our introduction to Machine Learning (click here) Blog
Before discussing what actually an AWS SageMaker is and what it does, it is essential to understand the concept and working of AWS. The Amazon Web Services (AWS) is a subsidiary of Amazon.com which offers individuals, businesses and governments access to on-demand cloud computing platforms on a paid subscription basis. AWS allows its users to acquire a virtual collection of computers that can be accessed through the Internet, these virtual computers imitate most functions of a physical computer. AWS performs various functions such as database storage, compute power, content delivery, machine learning and other functions. Certainly, Amazon Web Services provide reliable, flexible, affordable and scalable cloud computing services allowing its users to create sophisticated applications. The users pay according to the usage and number of virtual computers, and not for all the functions. Indeed, AWS offers a multitude of products relevant to machine learning, which is an algorithm designed to measure quality, develop the model, tune and integrate the application.
After understanding AWS, it will now be easier to understand the concept of AWS SageMaker in machine learning. An Amazon SageMaker is a platform tailor-made for workflows of Machine Learning. It is a fully-managed platform which permits the developers and data scientists to construct, manage, train and organize machine learning models of all scale quite speedily and easily. Amazon SageMaker is capable of eradicating barriers that slow down the usage of machine language for developers. Moreover, AWS SageMaker is designed with a mindset allowing the machine learning community to seamlessly adopt it as well as to stress-free deploy various trained models to production-ready hosted environments. It also offers Jupyter, which is an integrated authoring notebook instance designed to provide easy access to the data sources in order to perform proper exploration and analysis, without the management of several servers. Furthermore, it allows common and standard optimized machine learning algorithms to run effectively against large data within a distributed infrastructure. It definitely provides a flexible distributed training choices allowing its users to adjust their workflows through native support of algorithms and frameworks. Deployment of a machine learning model into an encrypted, scalable and secure environment through single click launch using the Amazon SageMaker.
Undeniably, most developers find machine learning harder than other languages due to the process of building and training models along with complex and slower deployment of it into the production function.
For using machine learning, it is essential to first collect and prepare the training data that highlight important data sets. Selecting the framework and algorithm to be used is the second phase. Once a decision has been made about the approach, the training of models to provide predictions begin, which is a daunting task as it involves a lot of compute. It is important to tune the model in order to gain the best possible forecast and predictions, which is a manual and tedious task. Once a fully trained model is developed, it is vital to integrate the model with the application and deploy it on the infrastructure which will conduct the scaling. Unquestionably, these steps are again quite tedious as it requires access to large compute & storage, time and specialized expertise in order to optimize every part of the model. Hence, Amazon SageMaker comes in handy as it eliminates the complexity for the developer. The Amazon SageMaker encompasses various modules which are compatible with other machine learning models along with having the capability to be used independently.
Amazon SageMaker works in a three step process of build, train and deploy. The first step is "build" where Amazon SageMaker makes easy to construct various machine language models and also gets them prepared for training by providing all the things needed. It also connects training data along with selecting and optimizing the framework and algorithm for the application. Furthermore, it helps its users to explore and visualize training data sets and connects them directly with the data in Amazon. Once you have completed the step build, the training begins, where the SageMaker allows single click training of the model through a management console. It definitely manages the entire infrastructure making the scaling and training an easy and fast task. Also, it automatically tunes the model in an attempt to achieve the highest possible accuracy. In the last step, Amazon SageMaker deploys the algorithm and model into production in order to generate real-time predictions. Amazon SageMaker takes away the heavy lifting of machine learning, so building, training, and deploying machine learning models become easy and faster.


text:
Tired of being repeatedly passed up for promotion and while others get ahead?
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- Best match
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text: To register your account on the NOITU portal for the FIRST TIME, please fill out the form below and click submit. If you have already registered, but have forgotten your password, you can request a new one here. If you are not receiving email from us, please make sure that you have whitelisted mail from firstname.lastname@example.com. If you have difficulty with this form, please contact us.


text:
The WWE House Show is a House show produced by World Wrestling Entertainment on July 28, 2012 at the Freedom Hall Civic Center in Johnson City, Tennessee.
Match Results
- (c) refers to the champion(s) heading into the match.
- Drew McIntyre & Ted DiBiase defeated Camacho & Hunico
- Jinder Mahal defeated Percy Watson
- World Heavyweight Title: Sheamus (c) defeated Alberto Del Rio in a Last Man Standing Match
- Justin Gabriel defeated Leo Kruger
- Chris Jericho & Christian defeated Cody Rhodes & Dolph Ziggler
- WWE Heavyweight Title: CM Punk (c) defeated Daniel Bryan and Kane in a Triple Threat Match
See also
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text:
Ibec/ISABC speaking event - Cancelled
Dublin 18 October 2018 Shelbourne Hotel
We are happy to announce that a collaboration has begun between ISABC
and Ibec. Marc Coleman, the Head of International Business
Development at Ibec, who has approved this message, made a
presentation to the ISABC Board at its meeting on Tuesday 11th
September on how the two organisations can cooperate for the benefit
of the members of both in Saudi Arabia. The ISABC Board responded
positively to what Mr Coleman proposed.
As a first step Ibec is going to host a joint Ibec/ISABC speaking event on
the opportunities that now exist in Saudi Arabia for Irish business.
This will take place on Thursday 18 October in Dublin from 11am and will be
attended by the Saudi Ambassador HE Mr Nail Al Jubeir and the CEO of
Ibec Mr Danny McCoy, and a Saudi speaker, with possible ministerial
representation. The venue is the Shelbourne Hotel.
Would members of ISABC who wish to attend please let Samiha at
not yet members but interested in business in Saudi are very welcome.
This collaboration with Ibec, with its 7500 members and wide range of
expertise and services, is a big step forward for ISABC and its role
for Irish business in Saudi Arabia and we encourage members not to
miss this networking event on 18 October. We shall inform you of the
programme and lunch arrangements shortly.


text:
- Idea Lounge
- The Coaching Habit
The Coaching Habit
This book on Amazon
The truth is, you can't work any harder than you are already. My guess is that you're feeling overconnected, overcommitted and overwhelmed … at least, some of the time. It's not about working harder, it's about having more impact.


text:
I know they are some who would consider themselves libertarians here which is fine as there is elements I and am sure many others can admire.
However one issue I have always been perplexed by and an accusation aimed at the movement is, Libertarians offers nothing for the poor and most vulnerable in the world. This thread was inspired by a chap who is aiming to represent the LP party in 2020 who is adamant the welfare state needs to die as obviously those that depend on it will all instantly go get well paid jobs.
Feedback appreciated.


text:
Lacie Sphere
The LaCie Sphere is as practical as it is beautiful. It features high-speed USB 3.0, which makes file transfers and backups nearly three times faster than with USB 2.0. Its 1TB of storage also gives you enough space for years of backups or an extensive photo, video, and music library. The LaCie Sphere is even powered through the USB cable, so no power cord is ever necessary.
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text:
No child should be exposed to violence, abuse or neglect. Yet in Cambodia the situation is dire for many. One in two children has experienced severe beating, one in four has suffered from emotional abuse, and one in 20 has been sexually assaulted. Many children are trafficked, forced to work, separated from their families and unnecessarily placed in residential care institutions.
Momentum is increasing for Cambodia to introduce laws to protect children, however there is no comprehensive, planned system in place. Developing a national vision on which to base a legal framework is the first step in realizing legal protection for children.
Children and adolescents remain at high risk of dropping out of school, teenage pregnancy, child marriage and violence. This is due partly to social attitudes that perpetrate violence, and partly to the limited number of services designed with children and adolescents in mind in key areas such as education, social work, health and justice.


text:
Providing cannabis plants a soil abundant in beneficial microbial life is the secret behind utilizing organic nutrient sources.
Nutrient Cycling in Nature
Nature decomposes material that increases the soil structure of soils and fosters microbes.
How does it work: A leaf falls down from a tree in a forest, covering the ground. Sitting there the dead leaf now starts to break down, being decomposed by the environment and microorganisms. This natural decomposition process creates food and habitat for microscopic fungi and bacteria, as well as larger organisms like earthworms.
Essentially this is how a forest grows itself. The dead leaves fall to the floor and enrich the soil from which it came. This natural process helps sustain and grow the forest without the need of human intervention. Most plants in the world already depend on this age-old process of working with microorganisms to obtain the nutrients required for growth from the soil.
Fungi and bacteria work together to break down organic material. In soil, speeding up the decomposition rate means that plants can utilize nutrients from organic material quicker.
Bone meal, blood meal, chicken manure, and nutrient-rich compost are all examples of organic matter that are not all readily available for your plants absorption. These are slow-release fertilizers. Some of the nutrients, are released and absorbed quickly, while others must be 'mined' down into smaller particles in order to be absorbed by a plant. This means the fertilizer needs to be broken down further in order for it's nutrients to become available for plant usage.
Best way to speed up this process?
Just maximize the beneficial fungi and bacteri
Dead material sources are full of nutrients, which is why increasing the fungi and bacterial levels in your soil is an effective way to help cannabis plants absorb more nutrients from the soil.
Try this experiment in a local forest:
- During fair weather, find a thick pile of fallen leaf litter underneath a tree.
- Dig into the leaf pile until the topsoil level is reached – you may see white saprophytic fungi on leaves as you get deeper.
- Pull back the topsoil and take a look at the plant's roots. If you see a white fuzzy fungi growing directly on roots then you've found mycorrhizal fungi, a naturally-occuring beneficial fungi that forms on plant roots.
While most of what is covering leaf litter, mulch and compost is actually Saprophytic fungi, the fungi that grows on plant roots is what's called Mycorrhizal Fungi and it helps plant absorb nutrients.
Beneficial Fungi
Mycorrhizal fungi has a symbiotic relationship with plants. What mycorrhizal fungi does is live as a host on your cannabis roots.
Why does it need a host? Because the roots contain much-needed carbohydrates for the fungi as well as a home.
So what do plants get in return? This beneficial fungi helps to feed the plant nutrients from the organic matter broken down in the soil. This plant-fungi association is in order to create a larger habitat for the fungi to live on – it's win-win situation for both the plants and fungi in most circumstances.
While saprophytic fungi are the main decomposers of the fungal kingdom, mycorrhizal fungi has been shown to be responsible, either directly or by association, for the creation of strong enzymes that break down dead material sources in the soil.
Benefits of mycorrhizal fungi plant associations include
- healthier plants
- quicker growth
- enhanced resistance to pests and diseases
- increased drought resistance
- reduced transplant shock
- higher yields
Creating an optimal soil environment for mycorrhizal fungi to flourish is the backbone of the True Living Organics method which is based off of this book written by the Rev.
True Living Organic practices are not strictly for outdoor growing. Fungus and bacteria will still be doing it's job indoors too 🙂
Organic Soil Mix Considerations
Mycorrhizal fungi is extremely delicate and can be wiped out easily. Be careful not to use any salt-containing fertilizers such as most readily available chemical fertilizers. Adding salt to fungus will simply dehydrate it, similar to putting table salt on a slug.
Keeping the soil's aerobic bacteria levels high is a key to success in True Living Organic growing method. Make sure your soil has a weath of aeration – TLO mixes generally consist of roughly 1/4 perlite. Using perlite in the soil is basically like having a bunch of artificial air pockets throughout your mix. Microbial life needs to breathe, and will flourish in air-filled environments, taking advantage of these air pockets.
Coco-coir is also a major addition, fluffy, airy and retaining 10 times its dry weight in water. Be sure to rinse the coco-coir out thoroughly: soak coco-coir in a bucket and draining out water out 2 or 3 times – being a coconut product, coco-coir more often than not contains salt.
Compost teas are extremely effective when done right, creating a type of microbial life explosion in the soil. Be sure to to aerate compost teas correctly, or you could be doing harm to integral micro-beasties instead of helping them. Read a compost tea how-to article here – http://www.finegardening.com/brewing-compost-tea
FoxFarm's Happy Frog fertilizer comes loaded with mycorrizal fungi as well as bat guano, kelp meal, alfalfa meal, fish meal and humic acid. A safe bet for True Living Organics soils, this cocktail of fertilizers is ideal for your plants. Happy Frog fertilizer is slow-released and can be applied mixing directly into your soil, sprinkling onto your topsoil or making 'spikes' (probe a hole into the root-zone soil, filling with the fertilizer). Happy Frog is a genuine wonder-product for organic growers.
For information about building an optimal soil-mix maximizing mycorrhizal fungi, check out SKUNK magazine & the Rev.
The Rev's book True Living Organics: The Ultimate Guide to Growing All-Natural Marijuana Indoors is essential reading for the organic grower, and certainly not just indoor growers. The Rev explains the delicate symphony of soil microlife in an easy-to-read format suitable for readers of all levels. You will learn how to create a healthy micro-beastie friendly enviornment in your soil and the dangers you must look out for. Worm farms, organic tea mixes and soil amendments are all covered in depth. The book also contains detailed instructions on creating your own 'TLO' (True Living Organic) soil mix, complete with a wide variety of nutrition for plant. Part of this system focuses on pumping up the aeration of your soil in order to create a better habitat for mycorrhizal fungi. Fungi needs air to grow, and will flourish in properly aerated soil.
For those interested in the science of True Living Organics, you should pick up Teaming with Microbes: The Organic Gardener's Guide to the Soil Food Web. Written in an entertaining style, this book explains the fundamentals of microorganisms in your soil, and how they can benefit your plants. It also explains why chemical fertilizers are detrimental to soil health, injuring the microbial life of the soil food web. You will learn about the science behind why feeding your soil will in-turn feed your plant and how pumping up your microlife will increase your plants performance and nutrient availability.
Read next: [USA] Before You Buy Pot Seeds


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Dr. Rohit Gulati is a Pain Management expert in Delhi, presently practicing at his private clinic The Centre of Pain Relief, Delhi. He has completed his MBBS, DA, DMS from Sri Siddhartha Medical College, Karnataka.
Dr. Rohit Gulati worked at Indraprastha Apollo Hospital, Mata Devi Hospital, Sri Balaji Action Medical Institute, Delhi. He also gained experience by working with the leading pain specialists at Sri Ganga Ram Hospital.
Dr. Rohit Gulati is an expert in dealing with patients who experience pain due to cancer, Sciatica, Backache, Cervical, Migraine, Joint Pain, General Body ache, Elbow pain, Heel pain, Anesthesiology and all other kinds of pain.
Request an online appointment with Dr. Rohit Gulati and consult him live on OyeHelp.com


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September is Seed Pricing
Egalitarian communities have trouble recruiting and holding members who have strong business management skills. There are a number of reasons for this. One is that these people are often not looking for us – if you really want to run a company or sell things, you don't think to yourself , "i'll move to the country and join a commune." Another is that the corporate world highly values these skills and the egalitarian compensation package (which is you get what everyone else gets) compares poorly to the mainstream one (corner office, secretary, fancy car, social status, real and imagined power, stock options and distinctly unegalitarian salary) .
So while these communities are relatively successful keeping the production lines running and churning out seed packets and hammocks and tofu and nut butters, we are regularly understaffed when it comes to people who actually want to run these businesses or sell our products.
At a community meeting a couple months back i freaked out. It was explained to me that there was no systematic review of most of the prices of our seed packets. While we have increased operating costs and insufficient payment to many of our growers, most of our seed packs have not changed prices in the last 5 years. In essence, while our total revenues have been increasing, our margin on almost every seed packet has been going down for at least half a decade now.
Okay, back to first principals, if i am going to complain about this (which i felt like i had little choice about), i better be willing to step up and do something about it. Which is why this month is called Seed Pricing.
The process of analysis has actually been quite fun; i am working with a great little group which includes Acorn intern Clay, Ingrid, GPaul and Margot (who is not even a member). We have a large google drive spreadsheet with our own current and historic prices, other companies in our niche prices for similar and identical seeds (sometimes they only sell non-organic versions, further complicating the analysis), normalized allied companies prices (since they have different packet sizes), calculated price differentials between our prices and the average normalized allies prices, recommended price increases that keep us below our allies and on and on. It has been great to see this spreadsheet grow as we have entered more and more data, building a stronger and more precise case for how much prices should go up for our most popular varieties.
An early significant realization is that so little has been done for so long that we are not going to try to start by doing a comprehensive analysis of our entire product line. Instead we are looking at our best sellers, and starting by fixing the prices of what we sell the most of. And building a methodology which can be used next year for a more complete analysis.
What is also clear is that our dozens of hours of work will result in tens of thousands of dollars more income for Acorn and improved compensation for our growers at LEF and Twin Oaks. It does not take an MBA to know that this is a good thing.
[Edited by Judy Youngquest]
7 responses to "September is Seed Pricing"
North Star says :
There are some egalitarian communities that have morphed into worker-owned coops or even transformed themselves into publicly traded corporations. Israeli kibbutzim come to mind, as do some NYC housing co-ops.
Someone with business management skills might want to live in a community like those.
I suppose it depends on what the goals of a community are. To enrich the lives of the founders? To grow and expand as egalitarian communities? Or to effect change in the broader society?
Makes me wonder where Twin Oaks or Acorn will be 20 or 40 years from now. Twin Oaks has certainly changed a lot from its founding.


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Shaklee was looking for a compensation platform to reduce the risk of existing systems and support their multi-level marketing strategy. Data readiness and changes in payment plans were top of mind in deciding to move forward with a faster, more automated system. With over half a million members spread across seven different countries, continuous improvement of their compensation structure for their multi-national distributorship was one of the most important factors to the Shaklee business.
Shaklee turned to CallidusCloud for a partnership that would to extend a best-in-class commissions system to meet their genealogy and real-time volume needs worldwide. The cloud-based multilevel marketing compensation strategy scales and supports member additions to complex hierarchies, assigns real-time transactional volume to each distributor, and pays based on target revenue attainment. Having fast and accurate incentives for distributors is critical and the lifeblood of Shaklee's business.
This Multi-Level marketing compensation strategy eliminated manual processes and maintenance costs while reducing the risk of legacy systems. The solution meets Shaklee's genealogy and real-time volume needs of the business.
In a Salesforce AppTalks Session, Shaklee CIO, Rich Libby, gives insight on why they chose CallidusCloud Commissions, the benefits they received, and provided peer advice on how to win big with multi-level marketing processes.
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Carla Standard
Cover with fixed aluminium structure composed of modules of 2.09 m in length between axles, each module is equipped with side hatches elevating type guillotine up to the ceiling, which allows the ventilation of the premises to 90%.
Independent high and low hatches manipulation allows a combination of the opening of the cover in function of the station and the climate.
Indoor fixed model is the only one that offers a true security barrier to prevent access by children and pets without the supervision of an adult.
- White RAL 9010
- Green RAL 6009
- Beige RAL 1015
Polycarbonate ribbed sheet transparent (polycarbonate compact transparent option).
Any other color of the RAL or finished wood.
- Two funds fixed transparent sliding doors with double stations.
- Height of step under trap doors of 1.95 m.


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A group of 12 design students from Art Center College of
Design in Pasadena, California conducted an experimental term
working unplugged, without computers and smartphones for the
first six weeks, using exclusively traditional analog methods
and techniques to create powerful communication.
Berlin: Unplugged
Study Abroad
While in Berlin, we explored how our sensibilities and skill sets could be expanded through working unplugged and analyzed how we could take that experience back into our normal digital working life. By stepping away from our digital dependence, even for a while, could we redefine a balance between technology and daily life? The result was an exhibition in Berlin and Los Angeles: Haupstadt Frottage, Urban Haiku & Low-Tech Parametrics.
The projects created during this time included: "Impressions of Berlin Newspaper," a "B" logo, Letterpress, Zines based on Berlin neighbourhoods, and posters inspired by the city of Berlin. All works were either completely analog or inspired by analog practices.


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Torino - Parma
Serie A - 18 March 2020
Serie A – Follow the Football match between Torino and Parma live with Eurosport. The match starts at 17:30 on 18 March 2020. Our live coverage lets you follow all the key moments as they happen.
Who will come out on top in the battle of the managers Nicolò Frustalupi or Roberto D'Aversa? Find out by following our live matchcast.
Have your say by voting on who will win between Torino and Parma? Enjoy some pre-match reading with related articles about these two Enjoy some pre-match reading with related articles about these two Football teams.
Head-to-head: see historical stats and visit our detailed profiles for Torino vs Parma. Get all the latest on Football: fixtures, results and tables.
No comments for this event.


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In this digital age, from making payments to saving documents, you can do almost everything with just a few taps on your mobile phone. Furthermore, there is one more productive feature which many people are still not aware that they can sign a document on their iPhone or iPad as well. Apple has added this function for those who usually do paperwork a lot, but in a certain scenario, if they could not able to attempt physically. At the time, this feature works like a stroke of a luck.
Now iOS users can easily use a digital signature on the scanned document and send them to the concerned parties. You can indeed sign a document on iPhone itself while you are on the move and away from your workplace. So, let find out how to sign a document on iPhone and iPad.
How to Sign a Document on iPhone or iPad
Step #1. Let us presume that you have received an email with an attached document, which needs your urgent signature. So open your mail app on your iPhone and then open email and tap on the attachment.
Step #2. Now, it will show you a preview of the document which needs to be signed. Now tap again, and that will open up some options for you. At the bottom right corner of your screen, you will see a Markup toolbox, tap on it.
Step #3. Next, it will automatically open reply option. First, if you wish to narrate a reply or to add something to the document you can do that before sending. Tap on the signature button at the bottom right of your screen.
Step #4. Now just use your finger and make your signature in the given space and tap on "done" at the top right of your iPhone screen. This will save your signature forever which you can use later as well. You may also change the signature if you wish to.
Note: You can sign that document in two different ways. 1. If you already have a signature in your phone you can use it, or 2. If you don't have a signature, you will be asked to create one. You can create a new signature on a landscape view which will open up when you tap the signature button.
Step #5. Return to the document for which you need to sign and place your signature at the desired place. Remember, you can also resize your signature by first dragging it to the spot and then using the blue corners.
You may also change the color of the signature by using colored circles given at the bottom. Tap the "Done" button at the top right of your screen.
Step #6. Now, You will be automatically returned to the reply email. The document now has your signature. You can add your comments on the email body and send the mail.
Please note that this process enables to open the reply email automatically, but you needn't do it each time if you have already saved your attachment on the iCloud. Whenever you wish to write another email and open the same attachment again from iCloud, you can just use the share option and select the email.
Once the email is opened just tap on the attachment and select "Markup" and then follow the guidelines given the same way.
You may also read some cool posts as well like How to Use Markup in Photos and Messages in iOS 10 on iPhone/iPad, How to Send iMessage Stickers Packs as Gift on iPhone or iPad, How to Find and Remove Other Documents & Data Files from iPhone and iPad.
Follow us on Facebook, Twitter, and Google Plus or even here in the comments boxes.


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Day 127 of 365:
{One Word Writing Prompt: Shadow}
Some shade and a welcome break:
…when you find refuge from the sun under the awning on a patio of a cafe on a busy street. Within this sheltered space, take a break, sip an iced tea and watch the city as it moves about…
…from your vantage point between the shadow and light.
-Janice 🙂


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The P88 isn't a bad tank.It's a pretty decent tank stuck in a bad situation.
Jryder, on Sep 11 2019 - 19:58, said:
No, that's just plain incorrect. It's a terrible tank.
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The New Way to Spy on Your Spouse | SpyFly Blog
The New Way to Spy on Your Spouse
Is there such a thing as privacy anymore? Let's be honest with ourselves, tracking someone's every move is a little weird. You never want to be "that" significant other looking obsessive or "crazy."
But what if the chances of you being caught were slim to none? Would you do it? In this day and age, people no longer have to snoop through their significant others' phone when they leave the room, are sleeping, or accidentally leave their phone at your house. With GPS systems constantly improving, there are now apps that do the dirty work for you.
In Horrible Bosses 2, viewers saw the power of "Find My iPhone" first hand. Dale's wife who was home with twins suspected her husband was up to no good. The app led her to a hotel room where she found her husband with his dolled up ex-boss, played by the one and only Jennifer Anniston.
So what are some ways to find out information, track text messages, and find out if your boyfriend is hiding his very own Jen behind the scenes? Not only are there applications that track location, but now there are apps that compile phone history and social media information. In a world that tracks everyone's every move, what will people do with this knowledge?
Apps for Spying on your Spouse
Find My Friendsallows you to track the whereabouts of your spouse, friends, children, etc. Users may share their locations which then appear on a map for others to view. This is a great device to see when your spouse leaves work or when your child heads home from school.
Connecttracks all social media sites in one place. This app follows anyone of your choice on sites like Facebook, Twitter, Instagram, and LinkedIn. Not only does the site track across all major social media platforms, but it does not require the consent of the person you are monitoring.
TopSpyis an undetectable app that monitors text messages, location, call history, social activity, phone conversations, browser history and more. TopSpy requires consent to begin with but essentially allows the person snooping to get a full look at what is going on inside of someone's mobile device.
Spy Sites
What is another way to find out secretive information? If you haven't already, it may be important to take a peek into your significant other's public records. SpyFly looks into your spouse's past and present information by gaining access to possible criminal record history, financial records, career information, and other important information you may not be aware of otherwise.
The Barriers
What are some barriers you may run into while searching? Apps such as Vault Stocks and Best Secret Folder allow a user to store confidential information, pictures, or videos in these safe locked folders. These folders require an extra password and are kept away in a person's smartphone. This is an extra precaution a significant other may take to make sure you are unable to reach this information. Although, just the presence of such an app on their phone should be a huge red flag.
Most of the apps require consent from the person you are attempting to track. There are certain functions that allow people to turn off the app or hide from certain followers. Also, if a person is aware he or she is being watched, they may be on their best behavior.
But remember…just as in the situation with Dale from Horrible Bosses, people forget they can be monitored 24⁄7. They forget their information is turned on or forget someone is watching them. In the case of Dale, his wife had his "Find My iPhone" information readily available, logged in, and was directed to his exact location.
The quickest way to get the most details about someone's secrets in one place is to perform a quick background check. You can make sure they aren't hiding any criminal records, phone numbers, or other dark secrets from you.
SpyFly was founded with the mission of making it safe and easy for people to find and learn the truth about each other online. By providing our members fast, easy and affordable access to public records, members can quickly make informed decisions about individuals they interact with. SpyFly provides searches for active warrants, driving records, arrest records, sexual predators and offenders, and several other public record information searches all in one place to keep you, your family, co-workers, and loved ones safe.


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Wearside furniture retailer ScS has been provided with a new £12m funding package by Lloyds Bank Commercial Banking to support its return to the stock market.
The Sunderland-headquartered firm – one of the UK's largest retailers of upholstered furniture and floorings – launched it first day of trading on the London Stock Exchange last week through its private equity owners Sun European Partners LLP.
The firm aims to raise £35m for its private equity owners, which acquired the business in 2008.
Lloyds Bank's North East-based mid markets and acquisition finance teams has delivered a revolving credit facility to the retailer, which ScS will use to support working capital as a newly-listed business.
Following Sun European Partner LLP's acquisition, the directors of ScS have implemented a strategy aimed at increasing sales through initiatives such as the introduction of flooring, operating House of Fraser's concession stores and the introduction of third party brands.
The strategy has resulted in ScS recording revenue growth of 23.6% in the last two years, while also growing its market share to 8.7%.
Founded in the 1890s, ScS operates 97 stores across the UK and 30 House of Fraser concessions, as well as online sales channels.
The vast majority of its sofas, chairs and corner units are made to order and sourced from UK-based suppliers.
Ron Turnbull, chief financial officer at ScS, said: "This new funding underpins the confidence felt throughout the business in recent years and further strengthens our financial position.
"With the support of Lloyds Bank post-IPO, we have a solid platform from which to capitalise on opportunities presented by the recovering economy."
Andrew Hopper, relationship director at Lloyds Bank Commercial Banking, said: "ScS has been on a steady upward trajectory in recent years, with economic confidence leading to increased consumer spending.
"An uptick in the housing market has also boosted ScS's fortunes and the positive reception from investors to the IPO shows a wider confidence in the business.
"We are pleased to be supporting ScS and its ambitious management team in this next stage of growth."
Credit and debit card acceptance facilities for ScS's retail estate and online store are being provided by Lloyds Bank Cardnet and legal advice is provided by Ashurst LLP.


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- 750g sweet potatoes, cut into chunks
- 25g sesame seeds
- 8 lamb cutlets
- Cooking oil spray
- Bunch of spring onions, trimmed and thinly sliced
- 2tsp grated fresh ginger
- 250g each sugar snap peas and green beans, steamed, to serve
- Cook the sweet potatoes chunks in a large pan of boiling water for 8–10 min until tender, then drain.
- Meanwhile, sprinkle the sesame seeds over a large plate. Firmly press both sides of each lamb cutlet into the seeds to coat. Spray a large frying pan with oil and put over a high heat, then cook the cutlets for 2 min on each side for medium or until cooked to your liking. Set aside to rest for 2 min.
- Spray the frying pan with a little more oil and put over a medium-high heat. Add the spring onions and ginger and cook, stirring, for 1–2 min. Add the cooked sweet potatoes and mash roughly.
- Divide the mash among 4 serving plates, then top each with 2 lamb cutlets. Serve with the steamed sugar snap peas and green beans.
Nutrition per serving
Read more on how we calculate nutrition.
370 23.4g 11.7g 3.6g 9.6g 15.2g 0.3g 163mg 46g 4.8mg


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My name is Bridgett McGowen, and as the founder and owner of BMcTALKS Academy, I help businesswomen be the most engaging, dynamic, incredible communicators ever!
I have spoken on programs alongside prominent figures such as Former President Barack Obama; Oprah Winfrey, Deepak Chopra; Major League Baseball sensation Alex Rodriguez (A-Rod); and Shonda Rhimes, American television producer, screenwriter, author, and the creator of ABC's primetime hit series "Scandal." (I should do a mic drop right now, but I'll continue.)
The prestigious University of Texas at Austin has identified me as a master presenter, and I have made hundreds of presentations all around the globe to thousands of professionals from all walks of life - presentations that have garnered serious applause and that have had event organizers contacting me to come back again and again.
Companies and organizations such as Vanguard Investments, LifeLock, Symantec, Kentucky Fried Chicken, McGraw-Hill Education, LinkedIn Local, and Society for Human Resource Management (SHRM) have sought after my presentations.
Forbes Coaches Council selected me as an official 2019-2020 member, I have been quoted by Transizion, and I have contributed to Thrive Global and Up Journey. I have appeared as a guest on The Training and Learning Development Company's TLDCast; Phoenix Business Radio; and on 2018 Miss Missouri USA and founder of Highlights 'n Heels, Tori Kruse's interview series to showcase my expertise in the professional speaking industry.
Award-winning diversity and inclusion strategist Simone Morris invited me to be a guest on her Power of Owning Your Career Podcast to discuss how to use your voice to own your career. I have also appeared on David Bryson's podcast "Why Can't You?" to discuss that very topic and the genius we all have. My work in professional speaking and public speaking coaching has been highlighted by VoyagePhoenix Magazine; award-winning branding and consulting agency Catalyst; The Startup Growth; and my alma mater, Prairie View A&M University.
In addition to being a professional speaker and presentation skills coach, I am a Forbes contributor and a published author with two books that both published in 2019, REAL TALK: What Other Experts Won't Tell You About How to Make Presentations That Sizzle and Rise and Sizzle: Daily Communication and Presentation Strategies for Sales, Business, and Higher Ed Pros. REAL TALK is listed as number 3 on the book blogger Boove's list of Savvy Books to Help You with Career Development. My next book, Own the Microphone, is an amazing collaboration with 50 successful professional speakers from around the globe and is slated for an early-2020 release.
Now my mission is to help as many businesswomen as possible get the tools and skills they need to master their messages so that they can turn their voices into powerhouses, inspire millions, and build serious skillsets and mindsets that will lead to more and more opportunities.


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Followed all these steps and my hair is almost past shoulder length. I have lost the edges of my hair and from reading your article, I feel that my hair follicles could be clogged. This item is returnable This item can be returned within 30 days in most cases. Page 1 of 1 Start over Page 1 of 1. GH Gwendolyn Harper Apr 26, Help answer questions Learn more. Mix one egg with a little bit of honey in a bowl.


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Power of Goodness collects stories from the lives of real people
that depict instructional moments in how to rely on the power of goodness in difficult situations and the amazing results of doing so. Our vision is to inspire readers, listeners, viewers, and participants to act with courage and to bring good into the lives around them.
The stories are written for children and illustrated by children
in ways compelling to people of any age, depicting the excitement of action, the joy of seeing from new perspectives and the encouragement of small acts that make big differences, through books, exhibitions, talks and short workshops.
We invite you to browse the titles and look at the accompanying artwork. When you find a story that catches your attention, read it through.
What did the story make you think about?
Has anything in the story challenged your ideas?
Is there anything in the story that might apply to your own life?
Story Collection
The Power of Goodness: Art and Stories for a Culture of Peace
is a short story book with children's art from Chechnya, Russia and around the world illustrating narratives of nonviolence, healing and reconciliation. Together, the words and images capture the excitement of action, joy of seeing from new perspectives, and encouragement of witnessing how small actions make big differences.
These stories are written for adults but with language that is accessible to any age. The captivating children's art illustrating these stories adds a unique and moving dimension to the reader's experience.
With forwards from Pete Seeger and Musa Akhmadov these stories will inspire a new audience of readers and children's art lovers. Scroll down to read excerpts from the Forwards.
Schedule the Exhibition
This traveling exhibition presents original artwork by young people ages 6 – 20 from Chechnya, Russia and around the world illustrating stories of nonviolence and reconciliation from the lives of real people. These works capture the excitement of action, the joy of seeing things from new perspectives and the encouragement of witnessing how small actions make big differences.
For any questions, please contact the Peace Ministries Committee.
Power of Goodness: Stories of Nonviolence and Reconciliation grew from a book, Lighting Candles in the Dark, originally collected in English and published in the U.S.A. by Philadelphia Yearly Meeting (PYM, 1964), which later turned the copyright over to Friends General Conference (FGC, 1992 and 2001).
That book included short stories about people who showed bravery and courage as they dealt nonviolently with dangerous or difficult situations and social issues. Friends International Library committee added a pool of inspiring stories from many countries and cultures based on universal themes—courage, nonviolence, justice, friendship, cooperation, and care for the earth—that spoke to Russians and Chechens.


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‹ Back to Past Screenings & Events
YFS Past Screenings & Events
This screening took place on
This energetic and surprising documentary about one of the most provocative pop artists of our time is drawn from a cache of personal video recordings from the past 22 years, director Steve Loveridge's Sundance award winning MATANGI / MAYA / M.I.A. is a startlingly personal profile of the critically acclaimed artist, chronicling her remarkable journey from refugee immigrant to pop star.
She began as Matangi. Daughter of the founder of Sri Lanka's armed Tamil resistance, she hid from the government in the face of a vicious and bloody civil war. When her family fled to the UK, she became Maya, a precocious and creative immigrant teenager in London. Finally, the world met her as M.I.A. when she emerged on the global stage, having created a mashup, cut-and-paste identity that pulled from every corner of her journey along the way; a sonic sketchbook that blended Tamil politics, art school punk, hip-hop beats and the unwavering, ultra-confident voice of a burgeoning multicultural youth.
Never one to compromise on her vision, Maya kept her camera rolling throughout. MATANGI / MAYA / M.I.A. provides unparalleled, intimate access to the artist in her battles with the music industry and mainstream media as her success and fame explodes, becoming one of the most recognizable, outspoken and provocative voices in music today.
Monday, October 15, 2018 at 6:00pm
Yukon Arts Centre
- Directed by Stephen Loveridge
- 2018, United Kingdom
- 97 minutes
Screening sponsor: Molotovs and Bricks Tattoo


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The mauve rice is very special type of rice that grows in Laos. We discovered it in a little ethnic ingredients store and I just had to buy a bag and try it. It tastes sweet, a bit chewy and it sticks together like arborio rice. All in all, it resembles Chinese red rice as far as consistency and mouth-feel go, but it's way prettier in my opinion :). We paired it with flavorful veggies and olives and nuts just as colorful as the rice and the result was very light and yummy :).
Of course, the result would be just as good with regular rice if you're looking for a nourishing detox dinner on the vegan side. Enjoy it with any rice you have :)
Last year: Spicy shrimp and wild rice soup (Chinese).
Ingredients (serves 2):
- 200 g mauve rice (from Laos)
- 1 tablespoon white balsamic vinegar (or condimento balsamico bianco)
- half a red, yellow and green bell pepper
- 1 carrot
- 1 handful of green olives
- 25 g pine nuts
- 2 tablespoons olive oil
- salt and pepper to taste
First of all, check out the pretty rice :)
Boil the rice according to package instructions (about 20-25 minutes). Finely chop the bell peppers and carrots and fry them in a little olive oil:
Stir in the veggies once in a while. They don't need to get really soft, just a little fried for extra flavor, so about 5 minutes will do, to get them to retain most crunchiness and vitamins. When the rice is boiled, add the vinegar to it and mix well (for extra tang, plain rice can be quite boring without it). Let aside. When the veggies are about done, also add the olives (sliced) and pine nuts:
Mix some more to get everything coated in the oil and leave on the heat for 1-2 minutes more for the pine nuts to catch some extra color and flavor. Meanwhile arrange the purple rice on plates, then top with the veggie-nut mix:
Season with extra salt and pepper if you want. It's done, dig in! :)


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Let the watching begin
I'm just here to pass along some information about two Auburn football players.
Linebacker Craig Stevens and offensive tackle Lee Ziemba have been named to award watch lists. It's a rite of passage for college seniors. These two players are, in my opinion, deserving.
Stevens has caught the attention of people who administrate the Nagurski Trophy. The senior-to-be was credited with 90 tackles last season. He also was one of the four players who participated in all 115 snaps of the Outback Bowl. They don't come tougher than that.
Ziemba is up for the Outland Trophy, which goes to the nation's top lineman -- on offense or defense. The Arkansas native is tall, strong, durable and generally good. What else can I say?
Photo credit: Todd Van Emst/Auburn University
Questions? Comments? Post directly to the blog below or email me at firstname.lastname@example.com.


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Chicago Style: It's the Big Book
This style is probably the one you are least familiar with. It is much more common to be used in publishing than student academics. That said, history and art majors, you may want to pay attention to this.
The Chicago Manual of Style
Chicago is the granddaddy of the style manuals. You'd recognize it by its two-inch spine proudly proclaiming the 16th edition. First published in 1906 by the University of Chicago Press, it was originally created as a way of standardizing not only style rules, but standards of typography and proofreading for the University. It soon grew beyond the University and became the standard style manual for many in the publishing industry.1
Unlike MLA and APA, both of which focus more on the writing and formatting of academic papers and research, Chicago has much broader uses. Chicago deals with all aspects of the publishing process according to both the author's and the publisher's needs. Because of this, it's going to have far, far more than you are going to need to just write your AH 110 class is going to ask for.
My best advice to you is do not get intimidated. The book may seem scary from the outside, but it has the best index of all of the style manuals. Whatever you need to find can be easily located either through its table of contents or the index. So don't get lost wading through the entire book, make it a surgical strike for the information you need.
Formatting a Paper
Because Chicago has become so important to the publishing industry, it doesn't provide a lot of guidelines specifically for students preparing a paper for class. It does offer standard manuscript preparation guidelines that you can find in our Chicago Style Guide, and we've also prepared a handy How to Format a Chicago Paper tutorial.
When it comes to title pages, Chicago doesn't really talk about it. If you look up title page in its index, it's going to tell you what the title page in a published book should have. A Pocket Style Manual offers an example of what students can do based off the Chicago guidelines,2 which can be found in How to Format a Chicago Paper. If you are unsure of what to do, you can always ask your teacher what he/she expects.
If you've been paying attention during these blog posts so far, you might have noticed I'm not using APA or MLA to cite my information. In fact, I've been using Chicago. Now you can scroll down and see how different it is. The reason I've been using Chicago is because it is less intrusive to the text. Instead of parenthetical citations, it uses either footnotes or endnotes. In a blog, endnotes are useful since it is read linearly. For a research paper, footnotes will be easier since they are seen at the end of each page.
So what should you know about Chicago citations? A complete listing can be found in our Chicago Style Guide, but for now, I'll give you the big ones.
- It's not as scary as you think!
- The reference/works cited page is titled Bibliography.
- You do not need both footnotes and endnotes. Choose one.
- You do need both the foot/endnotes and the bibliography.
- Footnotes and endnotes are complete citations. These are not simply author and date or page number. This has all the same information as what is listed in the bibliography.
- Foot/endnote entries are not the same as the bibliography entry. They may look the same at first glance, but there are major differences in punctuation. You must pay attention to the punctuation.
- Foot/endnotes have a first line indent, while bibliography entries have a hanging indent.
- Names in the foot/endnotes are written forward, while they are inverted in the bibliography.
1. The University of Chicago Press, "The History of The Chicago Manual of Style," University of Chicago Press, accessed August 4, 2014, http://www.chicagomanualofstyle.org/about16_history.html
2. Diana Hacker and Nancy Sommers, A Pocket Style Manual, 6th ed. (Boston: Bedford/ St. Martin's, 2012), 239.


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Exactly what is a Life InsuranceLife insurance is that ensures that your family members or dependents have got monetary protection in case there is your death. Essentially it is as vital an element of your long term planning as h2o is to fish. Based on the coverage period there are four types of existence insurance- term life whole life adjustable life and worldwide life insurance. So what type do you choose They both have its unique features thus read them very carefully and opt for the one that best meets your needs.
Insurance coverage Insurance
This is the simplest form of life insurance wherein a policy spans a specific period of time. In the event of death in this specific period starting from 10 to Three decades your beneficiary would likely receive the insurance benefit amounting for the face value amount of the policy. However in case you are alive at the time of the particular expiry of your plan you will not get back anything. Income insurance bupa So remember you cant consider this policy for an investment component.
Life insurance coverage Insurance
This insurance is a type of insurance when the term is your complete lifetime. Contrary to term insurance whole life insurance is money value insurance and monthly premiums remain consistent throughout the plan term. In this insurance your insurance company can devote a portion of your rates and might even share the proceeds from your time and money with you in the form of some sort of dividend.
Universal Lifestyle Insurance
Universal life is an advanced form of whole life insurance. Comparable to whole life insurance it is income value insurance and you avoid getting to choose how your premium money is being invested by the insurance company. As opposed to whole life insurance universal daily life insurance offers you flexibility due to the premium amount. You are free to decide the exact amount and time of this premium within the vast premium guidelines. According to financial circumstances also you can directly change the benefit of your policy once again within the policy some social norms. The changes to the quality amount however employ a direct impact on the growth of the cash value and maybe the dying benefit.
Variable Existence Insurance
Variable life insurance is really a another type of permanent life insurance. The only difference staying that this insurance gives you the pliability to choose the way your insurance company invests your hard earned money value. Under this insurance policy you can decide on having your money invested in a wide range of investment products including stock funds predetermined interest sub-accounts and highly-volatile worldwide growth sub-accounts.
If youre looking for existence insurance on the internet their tend to be tons of instant free quote websites not just for life insurance but for car health long term care and more. Several of the top rated term life insurance quote web-sites are accuquote.com selectquote.org reliaquote.com and ezinsurancequotes.net
Links Around the WebAuthority Resources-Wikipedia Insurance OverviewCNN3.org
Other Web-sites-What Smokers Want to know about Life Insurance
Income insurance bupa If youre an business owner you are liable for creating and maintaining an all-inclusive insurance portfolio. While fitness gyms can be a profitable opportunity they can also be incredibly risky establishments if you dont carry the right athletics and fitness insurance. That has a number of different exclusions recognition and coverage restrict options you must do your pursuit when you are quoting an exercise package insurance plan. Premium is very important in todays overall economy. With that being said premium is the final thing that should be considered when you are determining which commercial insurer is the best. Know what to search for when you are comparing gymnasium insurance packages and choose a reputable company offering a broad choice of coverages.


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There are few things more heart-warming than receiving feedback from a family whose baby or child is now sleeping… and not just sleeping, but sleeping well… and sleeping well independently!
I feel both blessed and privileged to have been welcomed into so many families lives and am honoured to share their thoughts about our experience together with you.
"Our toddler was experiencing multiple night wakings, early risings, taking 2 hours to go to bed and refusing naps. We had been living in a perpetual state of anxiety and stress since he was born. Our marriage was under strain. Our next child was due imminently and we were desperate for change. We couldn't continue on this way, let alone have things get worse when the baby came. Rather than file for divorce and drop the kids off on the nearest church doorstep, we contacted Kim. Kim was so professional and also like an old, trusted friend. She fixed ALL the problems immediately. We can't believe the complete transformation in our sleep and our family. Her greatest asset, apart from the know-how which we lacked, was being our cheerleader. We lacked support as we don't live near family and things had been so bad that we couldn't dump this on friends or a babysitter. We could now confidently say that we could get a friend to babysit without traumatizing them or our son. Our marriage and our sanity is restored. What an angel! Thank you Kim! We won't wait so long if baby has sleep issues!"
"As a new mom it can be scary & frustrating not knowing the reason or how to solve your child's sleeplessness. With Kim's guidance, vast knowledge, and full support, I was able to implement my sleep plan with confidence. I appreciate that she was flexible with scheduling, always transparent, and realistic with my sleep goals. Above all, Kim is a mom herself so she simply understands the challenges we moms go through. There were many other Sleep Consultants I could have selected, but I'm very glad I choose Kim because her support was as if she was present with me all along. Thank you kindly Kim."
"My friend said it all too well: you cannot keep doing this to yourself. You simply cannot be a good mother if you are always tired and as a result cranky! Let's get you some help! And help is what I sought to help manage my children's sleep. It became more and more taxing to face the hours and minutes and seconds during the day as my nights became a sheer gong show whereby I was running back and forth between my 6 month old and 3 year old preschooler. I then found Kim who was a blessing and an angel. Truly, I am in debt to her as her advice resonated with my family and her support was just infinite. It's been a few months now of steady sailing but had it been without Kim Pawlak, I could have easily drowned in 2 feet of water. Thank you Kim."
"I thought I had baby sleep figured out early – we had a "unicorn" baby who slept through the night starting at 8 weeks! Then around 9 months old, she started waking during the night more and more often, but it was always related to something (teething, crawling, sickness etc) and she would eventually return to sleeping through the night. Leading up to her first birthday, she was up 1-2 times a night, every single night. Things only got worse once I returned to work full time, she would wake anywhere from 2-5 times a night and often it would take 1 hour or more to get her back to sleep. Our life was miserable and neither of us could function at work, and our beautiful baby was a cranky tired mess. Life was pretty bleak. We had a unique sleeping arrangement (we shared a one bedroom suite so our baby was in our room) so that added an extra layer of complication. We called Kim after a particularly bad night and I am so so so glad I did. She was able to start working with us right away, and she tailored our sleep plan to fit out unique sleep situation perfectly. The first couple nights weren't the easiest, and if I had just been reading about sleep training through a book I wouldn't have felt confident enough to stick to the plan. But having Kim there to reassure us that we were doing everything right was immensely helpful. Our baby even got sick half way through the training and there was zero pressure from Kim to continue the training until our baby got better, which was much appreciated. Fast forward 3 weeks down the road and our baby girl is sleeping 12 hours a night and we have our life back! The only regret we have is we didn't call Kim sooner...."
"Both of my children woke every 2-3 hours as infants, lucky my first born turned into a unicorn and started sleeping through the night the week before I went back to work. I had an unrealistic expectation that my son would do the same, however, I soon realized that this was not going to be the case. After a particularly bad night, I told my husband (somewhat emotionally) that 'We are getting a sleep trainer! I cannot take this anymore!" I found Kim's website and contacted her, we chatted on the phone and we clicked. I knew I could be vulnerable with her and let her guide us through this nerve racking experience. I followed her recommendations to a T and my son did beautifully. It has been a month and a half since we started and the money I paid was the best gift I have ever given myself. My son now goes to sleep with little fuss and will sleep through until morning. Kim was awesome and I felt like she was really there for me through this process. Thanks so much Kim :)"
If you feel as though you are in survival mode and have been looking for a light at the end of the tunnel, know that you don't have to walk this precarious sleep journey alone.


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"It's time to purchase a new jewellery piece, it's time to increase my collection. Should I invest in the latest and trendiest silver jewellery?"
If you are thinking like this, go ahead because silver jewellery is the latest craze and worth an investment. In fact, jewellery made of silver is famous since ancient times. People sometimes, either because of personal choice or influenced by others, invest a lot in jewellery pieces made of gold or platinum. They regret their decision later because, in just a few weeks or months, their jewellery moves out of trend.
This is a time when fashion changes daily; every day something new is launched in the fashion world. That's why you should invest in silver jewellery. The silver jewellery is not very expensive and you can get new designs all through the year, whenever fashion changes.
The silver jewellery people wear is usually blended with tiny proportions of other metals because 100% silver is too soft for most types of jewellery. The most trusted form of such a blend is sterling silver (having 92.5% silver and 7.5% other metals). However, there are various reasons which prove jewellery made of silver is the best choice. Here are some of them:
- The first reason is that silver jewellery is durable. It has more strength than other metals such as gold. If you are looking for something to wear every day, go for silver jewellery.
- When it is about looking stylish without spending much, look no further than silver jewellery. This jewellery is always light on the pocket and because of this, you can purchase a jewellery piece in silver whenever you like or whenever fashion changes.
- Silver jewellery is known to enhance the looks of a person sporting it. The shine and spark silver jewellery presents are completely gorgeous and this is the reason why silver jewellery is the latest craze among women.
- Silver jewellery presents endless options. New designs of silver jewellery are constantly invented which means that you get ample options to choose from. Whether you are looking for a bracelet, necklace, pendant, or ring, there are numerous options.
- Silver jewellery is hypoallergenic. It is seen that jewellery made of metals like brass and other base metals irritates the skin of the person wearing them. The silver jewellery from renowned brands like Begna does not contain inclusion of any allergy-causing metals. So, if you are allergic to metals like brass and nickel, you can wear the silver jewellery without any worries.
- The maintenance of silver jewellery is quite easy. It is a well-known fact that silver jewellery when not used for a long time, tarnish. The good news is that if silver jewellery is worn frequently, tarnish can be prevented. The oils released by human skin clean this metal, so stop worrying about the dirty look. Even if the silver jewellery goes dull, there are many simple ways to get the original shine back.
So, these are some of the many reasons which prove silver jewellery is always the best choice.
If you are interested in getting the latest and trendiest silver jewellery straight from one of the biggest fashion capitals, click here.


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7 November 2018 - The State University of New York - SUNY Oswego (United States), a member institution of the United Nations Academic Impact (UNAI) is organizing for this Friday and Saturday, 9 and 10 November 2018, the 12th Global Awareness Conference, which is a day and a half on campus conference that gives students, faculty, staff, and members of the local community the opportunity to learn about other cultures and global issues as well as present on topics they are passionate about.
Presentations will cover issues such as education as a human right, immigration and refugees, and the 2030 Agenda for Sustainable Development, just to name a few, aside cultural and social key aspects of some countries and information about study abroad opportunities, academic exchanges and the role of global education to engage students with multiple perspectives and dimensions to enhance cultural competence, expand worldviews, and promote deep understandings of world events.
The keynote speaker will be Suki Kim, an investigative journalist and novelist, who will speak about the situation in the Democratic People's Republic of Korea. She has wrote quite extensively about the current political situation in such country and her many articles and essays have appeared in various U.S. newspapers and media outlets. For more information about the event please e-mail to firstname.lastname@example.com


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