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Hair Loss Holistic Treatments Ebook
Peruvian Hair Loss Treatment
Peruvian Hair loss treatment is a natural product, best for hair loss restoration. The hair product works well because its composition is free from chemical impurities. Hair loss is a life-changing occurrence in the lives of many people. As much as people may make fun of a bald head individual, but they fail to understand that this individual is very frustrated as it is already. Hair loss impacts on the overall personality build of an individual. For some, it is what makes them feel less pretty while others have lost their self-esteem to hair loss. Even so, Peruvian Hair loss is not only a powerful anti-hair loss formula, but it also strengthens the hair. Biologically, the leading cause of hair loss is high production of hormone DHT which weakens the hair, and it begins falling off. The hormone DHT is a version of testosterone, but it is more active. The Peruvian Hair loss treatment, however, offers smooth, soothing sensation on the human scalp, thereby increasing the blood flow. Moreover, the hair formulae prevent the conversion of testosterone into DHT. Peruvian hair loss treatment is not only useful in restoring hairlines, but it also makes the hair bulky and shiny. Peruvian hair loss treatment works by stimulating the growth of the hair, thereby making it long and healthy. Read more here...
Peruvian Hair Loss Treatment Summary
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Hair Loss Black Book
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Laserassisted Hair Transplantation
Concurrent with resurfacing technology was the suggestion that a narrow band of thermally damaged tissue should be hemostatic and might allow for rapid and bloodless hair transplantation by insertion of thin slits of hair-bearing skin or individual follicular units into slits or holes made by one of these lasers. Although with the CO2 laser a bloodless wound can be produced by either an UltraPulse laser or laser with rapid scanning, the amount of oxygen diffusion through this area and the rapidity of establishment of a vascular supply to the hair matrix was questionable and so, yet another controversy (363-366) began in the mid-1990s. Walter Unger (367-370), a prominent hair transplant surgeon, first reported his experience in 1994 with the UltraPulse laser. He thought that laser-recipient sites had good hair growth but that it was delayed compared to control cold steel grafts. Fitzpatrick
Example from the literature
Slevin et al. (1990) asked 106 consecutive patients with solid tumours to complete questionnaires about their willingness to receive chemotherapy. They were told that the more-intensive regimen was likely to have considerable side-effects and drawbacks, such as severe nausea and vomiting, hair loss, frequent tiredness and weakness, frequent use of drips and needles, admission to hospital, decreased sexual interest, and possible infertility. They were given different scenarios, such as (a) small (1 ) chance of cure, (b) no cure, but chance of prolonging life by three months, and (c) 1 chance of symptom relief only. All patients knew they were about to commence chemotherapy, and thus considered the questions seriously. Cancer nurses, general practitioners, radiotherapists, oncologists and sociodemographicallv matched controls were asked the same questions.
Insulin Resistance associated but not required for diagnosis
The most distinctive feature is that of clinical androgen excess. Hirsutism is usually present and can range from mild to severe. Usually hair growth is present on the face and chin as well as the lower abdomen. It is also not uncommon to see frontal hair loss and thinning of scalp hair.
C Role of the Wnt Pathway in Regulating EpSC Quiescence and Activation
The choice between quiescence and activation of EpSCs, whether in the interfollicular epidermis or the hair follicle bulge, involves the Wnt signal transduction pathway ending in Tcf Lef1, which also operates in the embryonic development of epidermal structures (Gat et al., 1998 Zhu and Watt, 1999 Das Gupta and Fuchs, 1999). The Wnt3 gene is expressed in developing and mature hair follicles and its receptor, Disheveled 2 (Dvl2) is expressed in a subset of cells in the outer root sheath and in precursor cells of the hair shaft (Millar et al., 1999). Overexpression of both Wnt3 and Dvl2 give a short-hair and cyclical balding phenotype in mice resulting from structural defects and an abnormal profile of protein expression in the hair shaft. In quiescent telogen hair follicles, Lef-1 represses the activity of EpSCs, because active GSK-3P prevents P-catenin from dissociating from the APC protein, which degrades P-catenin. At anagen, Wnt proteins activate EpSCs by inhibiting the enzyme...
Conditioning for bone marrow transplantation
Cyclophosphamide is given intravenously, usually in 250500 mL of saline over 0.5-1.0 h. Side-effects include nausea and vomiting (usually relatively mild), haemorrhagic cystitis, cardiomyopathy, fluid retention and alopecia. The haemorrhagic cystitis may be prevented or greatly modified by giving mesna (2-mercapto-ethane sulphonate) intravenously to neutralize the effects of metabolites of cyclophosphamide in the urine. Mesna (40 of the daily cyclophosphamide dose) is given intravenously 30 min before each cyclophosphamide infusion and the same dose is given at 3, 6, 9, 12, 16 and 20 h after each cyclophosphamide dose. This regimen is repeated on each day that the cyclophosphamide is given and the day after the last dose. The cardiotoxicity of cyclophosphamide is not usually a problem at the doses quoted unless there is already cardiac damage. Late haemorrhagic cystitis (after 20 days) may occur in transplant patients but is usually caused by virus infections (particularly adenovirus)...
Searching For New Indications
Once a drug is approved for an indication, many years of its patent life have usually expired. Information gathered from Phase III clinical trials or from use of the drug under normal conditions (postmarketing) may suggest alternative indications that may extend the patent life. For an invention to be patented in the USA, it must be a new and useful improvement and not obvious (see also Chapter 35). Patentable categories in drug development include pharmaceutically active compounds, processes for making compounds, and compositions comprising an active compound and a pharmaceutical carrier (Hammer 1990). New formulations may satisfy these criteria and extend the patent life, e.g. minoxidil (originally used orally as an antihypertensive agent) as a topical preparation for the treatment of hair loss. New indications also help to keep up the 'noise level' for the product, enabling the marketing team to capitalize on new information that could potentially expand the market for existing...
Etiology of erectile dysfunction after radical retropubic prostatectomy
Miller et al. examined whether changes in serum hormone levels influenced erectile dysfunction after radical prostatec-tomy.30 They found a statistically significant increase in serum testosterone, free testosterone, estradiol, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) as well as a decrease in dihydrotestosterone (DHT).30 This implies erectile dysfunction after radical prostatectomy can not be explained by androgen deficiency.
Direct brow lift browplasty
The extent of tissue excision is marked with the patient sitting upright aiming to position the scar within the upper row of brow hairs. The lower skin incision is made with the scalpel blade bevelled such that the incision is parallel to the hair shafts. This obviates transverse sectioning of the hair follicles thus minimising brow hair loss. Skin and subcutaneous tissue, with underlying orbicularis muscle as necessary, are excised taking care to identify and therefore avoid damage to the supraorbital neurovascular bundle. If surgery is undertaken for seventh nerve palsy then tissue excision down to the periosteum with deep fixation of brow tissue to periosteum using interrupted 4 0 Prolene sutures is necessary. The deeper tissues are closed with 4 0 or 5 0 Vicryl taking care to evert the skin edges prior to skin closure using a subcuticular 5 0 Prolene suture which is removed after five to seven days. This layered skin closure approach facilitates a thin flat scar.
Compare Alexithymia And Coping Style Between People With Ms And Other People
Picardi, A., Pasquini, P., Cattaruzza, M.S., Gaetano, P., Baliva, G., Melchi, C.F., Papi, M., Camaioni, D., Tiago, A., Gobello, T., & Biondi, M. (2003d). Psychosomatic factors in first onset alopecia areata. Psychosomatics, 44, 374-380. British Journal of Health Psychology, 7,213-225. Van der Donk, J., Hunfield, J., Passcher, J., Knegt-Junk, K., & Nieber, C. (1994). Quality of life and maladjustment associated with hair loss in women with alopecia androgenetica. Social Science and Medicine, 38, 159-163. Wahl, A.K., Gjengedal, E., & Hanestad, B.R. (2002). The bodily suffering of living with severe psoriasis in depth interviews with 22 hospitalised patients with psoriasis. Qualitative Health Research, 12,250-261.
Physiological Evidence of the Disease Process in the Brain
Many persons with schizophrenia and their families attribute the illness to psychological stress alone, a conclusion that is inconsistent with psychiatric research (Holzinger, Kilian, Lindenbach, Petscheleit, & Angermeyer, 2003). However, why would we assume that individuals who experience or observe a condition would necessarily know its origins Does being bald give you insight into the hormonal changes that have taken place to bring about hair loss Certainly not.
Psychological Model of Adjustment to Cancer
According to Moorey and Greer's cognitive model of adjustment, the personal meaning of cancer, based on an idiosyncratic appraisal of the threat to survival and the threat to the self, is an important determinant of an individual's adaptation to their disease. Moorey and Greer's model helps to explain why any two individuals with the same disease may react very differently to a diagnosis of cancer. For someone who has relied heavily on their appearance for self-esteem, treatment associated with hair loss or scarring may be devastating. Someone else who
Cell and molecular biology
As the DKC1 -encoded protein dyskerin and hTR are both components of the telomerase complex (Figure 12.5), it now appears that DC arises principally from an abnormality in telomerase activity. Affected tissues are those that need constant renewal, consistent with a basic deficiency in stem cell activity due to defective telomerase activity. The demonstration of DKC1 and hTR mutations in DC families provides an accurate diagnostic test, including antenatal diagnosis, in a significant subset of cases (Table 12.6). For DC patients, this now also provides the basis for designing new treatments. For the wider community it provides the first direct genetic link between a human disease that is characterized by features of premature ageing (premature grey hair hair loss, early dental loss, abnormalities of skin pigmentation, nail dystrophy, bone marrow failure,
Ischaemic lower limb Chronic
E Examine the cardiovascular system, looking for signs of hyperlipidaemia, carotid bruits, signs of ischaemic heart disease, abdominal aortic aneurysm. If ischaemia is severe in lower limbs, there is shiny atrophic skin with hair loss or atrophic nails, ulcers tend to be painful and have a 'punched out' appearance (e.g. under toes or classically over lateral malleolus). Peripheries cool to the touch with prolonged capillary return time, weak or absent pulses. Listen for bruits. Buerger's test Elevation of the leg results in pallor, venous guttering, followed by dependent rubor.
Telomeres and Premature Aging
Among the first mouse models to show multiple signs of accelerated aging was the telomerase knockout mouse. These mice completely lack telomerase activity owing to a germ-line disruption in the gene encoding the essential telomerase RNA component, mTR (147). Interestingly, mTR- - mice are asymptomatic for the first three to four generations. Subsequent generations, however, are shorter lived and prematurely develop hair loss and graying, ulcerative skin lesions, delayed wound healing, reduced fertility, reduced stress resistance, and increased cancer. As noted earlier, mice have telomeres that are much longer than humans. It is notable, then, that the reduced longevity and fitness of mTR- - mice were not manifest until the mouse telomeres had substantially shortened to lengths more typical of those found in aged human tissues. Thus, this model demonstrates a critical role for telomere function not only in suppressing cancer, but also in ensuring many other aspects of organismal...
Prostate Epithelial Stem Cells
The hierarchical relation between the cell types is schematically illustrated in Fig. 1. The exocrine lineage, resulting in the tall columnar prostate-specific antigen-producing cells, is critically dependent on the hormone, dihydrotestosterone. After castration, more than 90 of epithelial cells die
Structure Of The Skin
The basal layer also contains melanocytes which produce the pigment melanin, which imparts colour to the skin and also protects it from the effects of ultraviolet radiation. Other cells found in the epidermis include Langerhans cells, which play a role in the body's immune defences, and Merkel cells, which are involved in sensory reception. Structures such as hair follicles, nails, and sweat and sebaceous (oil-producing) glands are appendages that develop from the epidermis and extend into the dermis. The dermis contains blood vessels, nerves, hair follicles, sebum and sweat glands. A deep plexus of arteries and veins is found in the subcutaneous tissue, and this sends out branches to the hair follicles and various glands. A second network of capillaries is located on the sub-papillary region of the dermis. From this plexus, small branches are sent towards the surface layers of the skin. The capillaries do not enter the epidermis, but they come within 150 to 200 pm from the outer...
Top Hair Solution Medicine In World
Regenerative therapies are available for acute and chronic skin wounds, hair loss, periodontal injuries and disease, and diseases and injuries of the cornea. thickness skin grafts. They suffer several problems, however. First, lacking blood vessels, they are slow to vascularize if the underlying wound bed is severely damaged thus, ways are being sought to seed endothe-lial cells into the construct that will form blood vessels. Second, they do no better than MSTSGs alone in restoring cosmetic appearance, sensation, or skin functions such as thermal regulation, because the repaired skin has no hair follicles, sebaceous glands, or sweat glands. Third, they are cryopreserved until use, which reduces their cellularity. Thus, it is cheaper to use an acellular dermal regeneration matrix covered with keratinocytes or MSTSGs to treat wounds with deep dermal damage. The matrix slowly degrades as it is invaded by host fibroblasts, which repair the dermis. Male pattern baldness is a genetic...
Steroid Hormone Regulation Of Telomerase In The Prostate
The overall picture for the normal prostate is that telomerase is actively repressed in an androgen-dependent manner, and that activity is upregulated after androgen withdrawal. In sharp contrast, this normal regulation of telomerase is lost in prostate cancer, because the majority of primary tumors display robust telomerase activity despite the presence of normal levels of circulating androgens. In fact, with respect to telomerase regulation, the response of prostate cancer cells to androgen seems to be exactly the opposite that of normal cells. Not only are cancer cells telomerase positive in the presence of androgen but telomerase activity is suppressed after androgen withdrawal (Fig. 4) (201). For example, Guo et al. found that hTERT mRNA levels increased in the hormone-responsive prostate cancer cell line, LNCaP, when treated with the nonmetabolizable synthetic androgen, R1881 (202). This effect was considered to be indirect, based on the kinetics of the response and also the...
Psychological Aspects of Thyroid Cancer
Thyroid cancer patients who had been treated with radiation were almost twice as likely to report an overall effect on their health as those who had not received radiation. Almost a quarter of the sample described symptoms that could be associated with thyroid dysregulation, for example dry skin hair loss poor concentration sleep disturbance fatigue weight change palpitations heat cold intolerance diarrhea constipation depression anxiety. Thyroid cancer survivors reported psychological problems, memory loss, and migraine headaches more frequently than survivors of other types of cancer. The authors conclude that the morbidity associated with a diagnosis of thyroid cancer is significantly more pronounced than generally understood 13 .
Clinical Findings and Diagnosis
Toe-web involvement is commonly bilateral, presenting with erythema, a burning sensation, pruritus and scaling, particularly of the fourth interdigital toe web space. Severe acute forms present with painful erythema and blistering in a similar pattern to that found in cases of acute eczema or pompholix. Patients with a history of atopy are predisposed to superficial infections by dermatophytes, and in these cases erythematous inflammatory fungal lesions coexist with patches of ecze-matous skin (Figure 9.18). Chronic plantar lesions develop asymptomatic large hyperkeratotic plaques and a particular form of toenail infection by T.rubrum manifests clinically as a subungual white onychomycosis. Varying degrees of temporary disability may result from severe infections. Children manifest scalp infections under the kerion clinical form with patches of nonscarring alopecia and boggy inflammation of the skin (Figure 9.19). Less commonly, adult travellers manifest...
Ar Structure And Function In The Prostate
The androgen hormone dihydrotestosterone (DHT) is the principal regulator of prostate development and growth during embryonal development and puberty (5). In the adult prostate, it is required for maintenance of tissue homeostasis and secretory function. The circulating steroid hormone, testosterone, diffuses into the cells and is there converted by the 5-a reductase enzymes to the more potent androgen, DHT (6). DHT and other androgen hormones present in the prostate cells bind to a high-affinity binding protein required for mediating their effects, the AR. It is a member of the superfamily of nuclear receptors, its closest relatives are the progesterone, glucocorticoid, and the other steroid hormone receptors (7,8). Binding of androgen hormones triggers activation of the receptor to a transcription factor that interacts with and regulates the activity of gene promoters containing androgen-responsive elements (AREs). Activation involves a cascade of activation processes and the...
Cognitive factors personality characteristics and core beliefs
Predisposing developmental factors are clearly linked to the development of several personality characteristics that are emerging as having predictive power in explaining some of the variability in adjustment. Whilst disrupted attachments in childhood have been discussed as having the potential to lead to stable attachment styles in adulthood, few studies have actually explored the role of attachment, and those that have, were unable to relate this directly back to early experiences. Picardi et al. (2003b, c, d) found higher levels of insecure and avoidant attachment styles in a small sample of people with newly diagnosed or recently exacerbated vitiligo and alopecia areata. Interestingly, their participants also had poorer levels of social support and it was hypothesised that this might result from difficulties in accessing social support as a result of the underlying attachment style. Two other cognitive factors have recently attracted attention in this area, alex-ithymia and...
Major depressive disorder
Depression is encountered in a wide range of other dermatological disorders (Panconesi, 1984 Gupta & Gupta, 1996 Woodruff et al., 1997 Picardi et al., 2000 Gupta & Gupta, 2003 Picardi et al., 2004 Sampogna et al., 2004). Depression may modulate pruritus perception in other pruritic skin disorders such as atopic dermatitis and chronic idiopathic urticaria in addition to psoriasis (Gupta et al., 1994). Higher anxiety and depressive symptoms (Ullman et al., 1977 Hashiro & Okumura, 1998 Kiebert et al., 2002 Zachariae et al., 2004) have been reported in patients with atopic dermatitis. The anxiety may be the feature of an underlying depressive illness in some of these patients. Chronic intractable eczema during childhood may be a sign of a disturbed parent child relationship (Koblenzer & Koblenzer, 1988) however, a major depressive disorder should be ruled out before a disturbance in the family dynamics is implicated (Allen, 1989). Chronic idiopathic urticaria has been associated with a...
Stimulation Of Hair Regeneration
Androgenetic alopecia, or male pattern baldness, is a genetic predisposition in which there is thinning and loss of the hair on the temples and crown of the scalp in an M -shaped pattern (Springer et al., 2003). The cause is sensitivity of hair follicles in these regions to the hormone dihydrotestosterone (DHT), which is formed in scalp cells from testosterone by the action of the enzyme 5-a-reductase. DHT acts to progressively shorten the anagen stage of hair growth while lengthening telogen, resulting in smaller hair follicles, thinner and shorter hairs and ultimately, many empty and involuted hair follicles. The follicles on the sides and back of the scalp are not responsive to DHT and so are spared. The standard treatment for pattern baldness is the transplantation of clusters of 1-4 follicles from the sides and back of the scalp to the temples and crown, very close together, a time-consuming and expensive process. Two over-the-counter medications, minoxidil (marketed as Rogaine...
Side Effects Of Selenium And Vitamin E
Excess levels of selenium ingestion can be quite toxic. Selenium supplements have been associated with gastrointestinal problems, pathologic nailbed changes and the loss of fingernails, temporary hair loss and even fatigue.62 However, at 200 g day these side effects, apart from some gastrointestinal upset were not observed in a past trial,3 but for the patient who believes in the 'more is better' theory, this could represent a potential problem. Clinicians need to advise patients on the potential harm that could result from taking too much supplemental selenium. A CDC report from 1983 highlights the dangers of high selenium intake.62 Individuals were taking a selenium supplement that actually contained hundreds of more micrograms and milligrams than was reported on the purchased bottle. This resulted in temporary and permanent nail and hair loss, and fatigue that was mentioned earlier.
Cutaneous Lupus Erythematosus
All forms of cutaneous lupus may manifest photosensitivity. Cases with acute SLE may present with the characteristic butterfly facial rash in addition to constitutional symptoms, whereas subacute cutaneous lupus occurs in about 10 of patients with lupus erythematosus. Common skin presentations include an annular scaly erythematous, psoriasiform rash involving light-exposed areas, which may present abruptly, extensor surfaces of arms, dorsa of hands, V of chest and upper back and face. Patients may also manifest a diffuse nonscarring alopecia. The treatment of choice is topical steroids in mild cases but systemic therapy with antimalarials, corticosteroids, and immunosupressants is usually required. Chronic forms of discoid LE present with weeks-to-months history of erythematous papules and plaques with follicular plugging and atrophy, with subsequent scar formation. The rash tends to occur on habitually exposed areas of the face, scalp, external ears, and hands. Scalp involvement...
Development of QoL research in dermatology
A 21-question format was suggested in 1970 to record, in a standard way, the impact of skin disease on QoL (Whitmore, 1970). Other suggestions concerning criteria for assessing the impact of permanent skin impairment (Committee, 1970) and systems for wider assessment of disability (Robinson, 1973) were also proposed. The first dermatology disease-specific instrument, the Psoriasis Disability Index (PDI) (Finlay & Kelly, 1985 Kelly & Finlay, 1987) was initially used to assess the impact of hospital admission on disability in patients with psoriasis and has subsequently been used widely (Lewis & Finlay, 2004). The use of validated, standardised general health measures in dermatology, such as the UK Sickness Impact Profile (Finlay et al., 1990) and the Short Form-36 (SF-36) (Nichol et al., 1996) followed in the early 1990s. Several dermatology disease-specific QoL measures for use in acne, psoriasis, atopic dermatitis, alopecia, leg ulcers and others were described during the 1990s and...
BDD and other body image pathologies
BDD presents as a preoccupation with an imagined defect in appearance or if a slight anomaly is present, the individual's concern is excessive (American Psychiatric Association, 1994). BDD is also referred to as dysmorphophobia and 'dermatological non-disease' (Cotterill, 1981) in the dermatological literature. In one study 8.8 of patients with mild acne had BDD (Uzun et al., 2003). The complaints in BDD commonly involve imagined or slight flaws of the face or head such as thinning hair, acne, wrinkles, scars, vascular markings, paleness or redness of the complexion, swelling, facial disproportion or asymmetry, or excessive facial hair. The most common areas of concern involve the skin and hair. Some associated features of BDD include repetitive behaviours such as excessive grooming behaviour. This may manifest as excessive hair combing, hair removal, hair picking or picking of the skin, or ritualised make-up application. The main purpose of the repetitive behaviour is to improve or...
The AR and Androgens
Strategies for hormonal therapy. LH-RH Luteinizing hormone-releasing hormone CRH corticotropin-releasing hormone LH luteinizing hormone ACTH adrenocorticotropic hormone T testosterone 5a-R 5a-reductase DHT 5a-dihydrotestosterone AR androgen receptor. Fig. 1. Strategies for hormonal therapy. LH-RH Luteinizing hormone-releasing hormone CRH corticotropin-releasing hormone LH luteinizing hormone ACTH adrenocorticotropic hormone T testosterone 5a-R 5a-reductase DHT 5a-dihydrotestosterone AR androgen receptor.
Genetic Theories
Another avenue of interest in the study of prostate cancer has been the effect of circulating androgens. Testosterone and its most active metabolite, dihydrotestosterone, are the principal steroid hormones involved in the growth and development of the prostate gland. Serum levels of these hormones have
Risk Factors
For prostate cancer, the most important risk factor is also prolonged exposure to steroid hormones, i.e. androgens. Early castration or genetic defects blocking androgen synthesis essentially eliminate the risk of prostate cancer, while more subtle abnormalities, such as qualitative differences in the levels of circulating androgens or qualitative differences in androgen receptor function or related signal transduction pathways due to various genetic polymorphisms may also alter the risk of prostate cancer in certain subpopulations.9 For example, genetic variations of 5a-reducatase may create more productive enzymatic conversion of testosterone to dihydrotestosterone (DHT), which has been suggested as one mechanism of increased prostate cancer risk.10 Studies have looked at the potential role of vitamin D receptor (VDR) polymorphisms in prostate cancer risk, particularly in African American men.11 It has also been noted that Black men of college age have 13 higher serum free...
Causal Models
This model assumes that a poor QoL is likely to be manifested by psychological distress, and that psychological distress is a latent variable that tends to result in anxiety, depression, despair, irritability and similar signs of distress. This much does seem a plausible model. However, a patient with poor QoL need not necessarily have high levels of all treatment-related symptoms. For example, a patient receiving chemotherapy may well suffer from hair loss, nausea, vomiting, and other treatment-related side-effects that cause deterioration in QoL. However, other cancer patients receiving non-chemotherapy treatments could be suffering from a completely different set of symptoms and side-effects that cause poor QoL for other reasons.
FIGURE 3.7 Diagram showing how Wnt proteins activate quiescent EpSCs of the hair follicle to become transit amplifying (TA) cells. At telogen, Lef-1 acts as a transcriptional repressor in the absence of P-catenin (P-C), which is degraded by GSK-3p. At anagen, Wnt activates the Disheveled 2 (Dvl-2) protein, which inactivates GSK-3p. P-C is stabilized and translocates to the nucleus, where it forms a complex with Lef-1 that stimulates gene transcription characteristic of TA cells. FIGURE 3.7 Diagram showing how Wnt proteins activate quiescent EpSCs of the hair follicle to become transit amplifying (TA) cells. At telogen, Lef-1 acts as a transcriptional repressor in the absence of P-catenin (P-C), which is degraded by GSK-3p. At anagen, Wnt activates the Disheveled 2 (Dvl-2) protein, which inactivates GSK-3p. P-C is stabilized and translocates to the nucleus, where it forms a complex with Lef-1 that stimulates gene transcription characteristic of TA cells. P-catenin to dissociate from...
All of the personality and cognitive factors described above have clear links to the types of coping strategies deployed by individuals. Shame-proneness, alex-ithymia, and avoidant-attachment style have all been linked to avoidant-coping strategies. For example, vitiligo and alopecia areata participants with higher levels of insecure and avoidant-attachment styles also had poorer levels of social support and it was hypothesised that this might result from difficulties in being able to access social support (Picardi et al., 2003b, c, d).
Vitamin D Action
1,25-VD, the bioactive form of vitamin D, was identified as a nutrient a century ago, and is the major regulator of calcium and phosphate homeostasis, responsible for maintenance of bone integrity, and also plays an important role in hair follicle cycling and mammary gland development. The biological effects of 1,25-VD are mainly mediated through the VDR, a member of the nuclear receptor superfamily, which heterodimerizes with the retinoid X receptor (RXR) and binds to response elements located in the promoters of target genes in various tissues, such as bone (osteocalcin, osteopontin, and beta 3 integrin), kidney (24-hydroxylase), and intestine (calbindin).6,7 Like other nuclear receptors, VDR contains an amino-terminal activation function 1 (AF-1) domain, a DNA binding domain (DBD), composed of two hexameric half-sites organized as direct repeats that recognize specific DNA response elements, and a ligand binding domain (LBD) that contains a ligand-regulated transcriptional...
Genetic Factors
Results for the androgen receptor (AR), which is involved in androgen binding and transport, are fairly consistent, showing that shorter CAG repeat lengths are associated with increased risk in most, but not all, pop-ulations.100-119 For the type II steroid 5a-reductase (SRD5A2), which converts testosterone to the more active androgen dihydrotestosterone, the results are mixed,110,119-133 with a recent meta-analysis showing modest
Sebaceous cysts
T B D Epithelium-lined, keratinous, debris-filled cyst arising from a blocked hair follicle. More correctly known as epidermal cyst. iP Despite their name, these cysts are not derived from sebaceous glands. Sebaceous cysts result from the cystic proliferation of epidermal cells within the dermis. The source of this epidermis is often the infundibulum of the hair follicle. Inflammation is usually a foreign body, granulomatous reaction to material contained within the cysts.
Hormonal Therapy
Finasteride and flutamide combined as androgen ablative therapy for advanced prostate adenocarcinoma have been studied. Finasteride inhibits 5a-reductase, decreases the conversion of testosterone to 5a-dihydrotestosterone and provides a more complete intraprostatic androgen block-ade.104 Combined therapy with these agents decreased serum prostate specific antigen (PSA) greater than either agent alone and accounted for an overall potency rate of 82 -with potency defined as the ability to maintain an erection satisfactory for sexual intercourse.104 Combined hormonal therapy has the promise of delivering sufficient androgen blockade while maintaining adequate erectile dysfunction. Greenstein et al. found that surgical castration with orchi-ectomy reduced serum testosterone to a level not statistically different than that with hormonal castration.108 Orchiectomy is associated with decreased potency and sexual activity.
Cancer Chemotherapy
Cancer chemotherapy, first experimented with in 1943 by employing mustard gas alkylating agents (DeVita et al., 1997), is typically associated with severe side effects because highly toxic compounds are used. This can be explained by the fact that most chemotherapeutic agents interfere with the cell division process. Not only cancer cells but also dividing healthy cells are tackled by the agent, with undesired side effects such as nausea, vomiting, diarrhea, hair loss, and serious infection as a consequence (Boyle and Costello, 1998).
Coronal brow lift
A bevelled high coronal incision is made within the hairline following the shape of the latter far enough posterior to position the subsequent scar 3-4cm posterior to the anterior hairline. The incision is angled to run parallel with the axis of the hair follicles down Post operative haematoma leading to flap necrosis, localised sensory and motor nerve damage, hair loss and unacceptable scarring are all recognised complications, the majority of which can be avoided with careful surgical technique.
Colon, E.A., Popkin, M.K., Callies, A.L., Dessert, N.J., & Hordinsky, M.K. (1991). Lifetime prevalence of psychiatric disorders in patients with alopecia areata. Comprehensive Psychiatry, 32, 245-251. Gulec, A.T., Tanriverdi, N., Duru, C., Saray, Y., & Akcali, C. (2004). The role of psychological factors in alopecia areata and the impact of the disease on the quality of life. International Journal of Dermatology, 43, 352-356. Gupta, M.A., & Gupta, A.K. (1998). Depression and suicidal ideation in dermatology patients with acne, alopecia areata, atopic dermatitis and psoriasis. British Journal of Dermatology, 139(5), 846-850. Gupta, M.A., Gupta, A.K., & Watteel, G.N. (1997). Stress and alopecia areata a psychodermato-logic study. Acta Dermato-Venereologica (Stockholm), 77, 296-298. Koo, J.Y.M., Shellow, W.V., Hallman, C.P., & Edwards, J.E. (1994). Alopecia areata and increased prevalence of psychiatric disorders. International Journal of Dermatology, 33, 849-850. Ruiz-Doblado, S.,...
Saw palmetto
The biochemical basis for the activity of saw palmetto against benign enlargement of the prostate almost certainly includes inhibition of the formation of dihydrotestosterone (DHT) within the prostate gland. Interestingly, saw palmetto inhibits formation of DHT in the prostate gland, but not in many other tissues and may not alter blood levels of this hormone.48,49 The action of testosterone and dihydrotestosterone on the prostate gland is markedly stimulated by the hormone, prolactin. Saw palmetto is reported to block the response of prostate cells to prolactin.50
Laser Hair Removal
Thermally nonselective but effective destruction of hair follicles in hair-bearing grafts, or for trichiasis, had been reported as early as the 1970s (393 -396) but hair removal by thermal damage confined to the hair follicle governed by the principle of selective photothermolysis had not been attempted. The first FDA-approved laser for hair removal did not depend on the pigmented hair as a target but instead a patented mineral oil lotion was used containing carbon-based material, which was presumed to seep into the follicles after waxing immediately prior to massaging of the lotion and thus provide a target for the laser. Presumably, the mechanico-acoustic wave appearing after the laser impact would then disrupt the base of the follicle so that the loosened hair would fall out and the damaged follicle would no longer produce hair. In 1995 Goldberg and coworkers (397,398) presented the first studies showing very short-term efficacy. Hyperbole from the mass media was unfortunately not...
Acute Pancreatitis
HUMAN HAIR GROWTH CONTROL (ALOPECIA) AND DERMATOLOGIC DISORDERS Functional TRPV1 is expressed in keratinocytes, hair follicles, sebocytes and sweat gland cells 151, 152 . In organ cultures, activation by capsaicin of TRPV1 results in premature hair follicle regression and apoptosis 153 . This finding confers a therapeutic potential for TRPV1 antagonists in the treatment of alopecia. In prurigo nodularis, enhanced TRPV1 expression was found that normalized during capsaicin treatment 154 .
Anti Androgens
Spironolactone is an anti-mineralocorticoid agent that also acts as an anti-androgen. It is a potassium sparing diuretic that in high doses (100-200 mg day) demonstrates significant anti-androgenic properties. Spironolactone interferes with testosterone biosynthesis by reducing 17-hydroxylase activity and thus lowers plasma testosterone. It also inhibits dihydrotestosterone's binding to the androgen receptor. It is not FDA-approved for treatment of androgenic symptoms but in many studies has been shown to be an effective agent in this regard. It is often combined with oral contraceptives to reduce testosterone action and production. is a nonsteroidal, nonhormonal antiandrogenic drug, which has been demonstrated to block the action of dihydrotestosterone (DHT) on androgen receptors. It has been associated with hepatocellular dysfunction. Finasteride is a 4-aza analog of testosterone and is a competitive inhibitor of both tissue and hepatic 5-alpha reductase. This results in inhibition...
The proliferation and differentiation of prostate tissue are modulated by growth factors15,16 as well as hormonal androgen therapy.17,18 Evidence of hormonal impact on the prostate is seen in atrophy of the prostate following castration,4 as well as treatment of BPH samples with a 5a-reductase inhibitor. When this inhibitor is given to patients, there is a regression of dihydrotestosterone (DHT) levels and a reduction in prostate volume.19,20 Recent data suggests that mutations in RNase L predispose men to an increased incidence of prostate cancer, which in some cases reflect more aggressive disease and or decreased age of onset compared with
Hormonal activity
Dihydrotestosterone (DHT), the 5a-reduced product of testosterone, binds to androgen receptors with 2.5-fold higher affinity than testosterone itself, and serves as the major regulator of prostatic tumor growth. Androgen-mediated cancer proliferation occurs by direct effects of androgens, indirectly by
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Modular evolutionary algorithms
Project description
This package contains the S-metric selection evolutionary multi-objective optimization algorithm (SMS-EMOA) and the non-dominated sorting genetic algorithm 2 (NSGA2) for multiobjective optimization. For single-objective optimization, classical evolution strategies and the rather unknown CMSA-ES (covariance matrix self-adaptation evolution strategy) are provided. Variation for real-valued and binary search spaces is included and new variation operators can be easily added thanks to the modular concept.
The package is geared to work with optimization problems as defined in the package optproblems. The whole package assumes minimization problems throughout!
The documentation is located at https://ls11-www.cs.tu-dortmund.de/people/swessing/evoalgos/doc/
Project details
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subset: commoncrawl


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Please allow 7 to 10 days plus post time for delivery
If you want to sleep at night not worrying about your horses shoulders rubbing then this is the rug for you.
The front has a large section of pleating which is also fully satin lined.
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If you want the very best for your horse then this is the rug for you.
Thank you to my beautiful models Amber MI and Mystica Amaria


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California judge rules law enforcement can't force suspects to unlock their iPhone using Face ID or Touch ID
Law enforcement officials can't force smartphone users to unlock their devices using fingerprints or other biometric features such as facial recognition, according to a Northern California court ruling from last week.
In this particular case, being heard in the U.S. District Court for Northern California, police were seeking a search warrant as part of a Facebook extortion case. The victim in the case was being asked to pay a sum of money to avoid having an "embarrassing" video released to the public.
Law enforcement wanted to use the search warrant to raid the property of people whom they believed to be suspects in the case. Through that raid, they also sought to unlock any phone on the premises with Face ID and Touch ID.
The court said that there was indeed probable cause to grant a search warrant, but that it was denied because the request to force the suspects to unlock their devices using biometric authentication "funs afoul of the Fourth and Fifth Amendments." From the ruling:
The Government, however, also seeks the authority to compel any individual present at the time of the search to press a finger (including a thumb) or utilize other biometric features, such as facial or iris recognition, for the purposes of unlocking the digital devices found in order to permit a search of the contents as authorized by the search warrant.
For the reasons set forth below, the Court finds that the Government's request funs afoul of the Fourth and Fifth Amendments and the search warrant application must be DENIED.
In further analysis, the court equated biometric authentication to a passcode rather than something like submitting to a DNA swab. It has been previously established that under the Fifth Amendment, a suspect cannot be compelled to provide the passcode of a device.


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Need a flight connection during the week or on the weekend? idealo has the information you need to find the perfect flight from Miami to Orlando. We've searched through the flight database and found that the lowest prices for the connection start at $69. Users choose American Airlines most of the time when flying this route. Find a direct flight to Orlando every day with American Airlines. For direct flights at the most affordable prices, book with US Airways. The cheapest tickets for that airline start at $69. The most affordable ticket prices for flights with stopovers start at $104 and for direct flights at as little as $69. Only 10 % of our users prefer stopover connections and 71 % prefer direct flights. The most popular stopover flights are those with stops in Washington DC or Key West. With a flight time of 4 hours and 3 minutes, flights that land in Key West are the fastest connections with a stopover. This connection is only 3 hours and 8 minutes longer than a direct flight. Whether you are looking for a stopover or a direct flight – find the right connection with our help.


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Pit Bull owners may be the only people who understand how cuddly the breed is, but they do have an intense need to chew. Without bones to chew on, they're liable to go for furniture, shoes, or anything else they can get their jaws around.
Thanks to their powerful jaws, not just any bones will stand up to a Pit Bull's chewing. Some bones are also more dangerous than others, as we'll discuss. That's why we've come up with this list of the top 5 best bones for Pit Bulls.
We'll discuss raw vs. cooked bones and other bone alternatives that may be safer for your Pit Bull as well as what to look for when choosing bones.
First, here's a quick rundown of our picks for the top dog bones for Pit Bulls.
Pawstruck 12″ Braided Bully Sticks for Dogs
Benebone Maplestick Real Wood Durable Dog Stick Chew Toy
Blue Buffalo Wilderness Wild Bones Grain-Free Dental Chews Dog Treats
Not all dog bones were created equal. Some types of dog bones can actually be quite dangerous for dogs, especially for Pit Bulls. Let's discuss the different types of bones and which types we chose for the best bones for a Pit Bull.
You may already know that you should never give your dog cooked bones from your dinner because they can splinter and hurt your Pit Bull's mouth or cause injury or obstruction in your dog's digestive tract. But did you know that those bones you get from the pet store can cause the same issue?
Those bones are also considered cooked. Not only can they splinter, but they can break your dog's teeth because they don't have enough give, and if they aren't big enough, your Pit Bull could easily break them into chunks that are small enough to swallow but big enough to block their digestive tract, potentially leading to a costly surgery.
These reasons are why we haven't included any traditional bones in our list of the best dog bones for Pit Bulls.
Many vets are now recommending raw bones for dogs as a healthy alternative to traditional bones. Raw bones are softer than cooked bones and are less likely to splinter or break teeth, but they pose the same risk of blocking a dog's digestive tract. Additionally, raw bones may contain bacteria that could sicken your dog or your family.
Only you can decide if raw bones are the right choice for your dog. Due to their potential risks, we've decided not to include them on our list.
Luckily, there are lots of alternatives to traditional dog bones that are much safer for Pit Bulls. Here are some of the more common types of other bones you may be thinking about giving your dog.
Rawhide is not the healthy dog chew that you've been led to believe. It's a byproduct of the leather industry and is made with toxic chemicals and can't be digested by your dog. They pose a choking risk to your dog, and if they make it into your dog's intestines, they can't be digested and can cause blockages that may require surgery. Additionally, rawhide may be contaminated with Salmonella.
It's so dangerous that both the ASPCA and the Humane Society of the United States list rawhide as one of the most dangerous products for pets. Luckily, there are plenty of chews and bone alternatives to rawhide that is much safer for your Pit Bull.
A great alternative to rawhide, bully sticks are made from dehydrated beef pizzle, which is meat rather than processed hide. Since they're made from meat rather than leather, they're more likely to be digested if your dog swallows a piece. Since the sticks are narrow, they're also less likely to caused intestinal blockages.
The only downside to bully sticks is that they tend not to be a long-lasting chew for intense chewers like Pit Bulls. Luckily, braided bully sticks are 3 sticks wrapped around each other for a longer-lasting chew than a traditional bully stick.
Generally, the safest type of bone for dogs, chew toys can be long-lasting with less chance of splintering or breaking off in large chunks than other types of dog bones. Some dogs don't like them due to their plastic texture, but many Pit Bulls and other dog breeds will happily spend hours chewing on their favorite chew toy. We've picked a couple of the most-durable chew toys that are Pit Bull approved.
Yak chews are essentially hardened cheese made from yak milk. They have enough give not to cause much risk of breaking a dog's teeth, but they last longer than just about any other type of edible bone for dogs.
The best part about yak chews is that the last little bit can be microwaved and turned into a cheese puff that's safer for your dog than the last bit of any other chew – no more wasting the last bits of a chew to keep your dog safe.
For dogs with strong jaws like Pit Bulls, dental chews are more of a quick treat rather than a long-lasting chew, but their texture is specifically designed to help clean your dog's teeth, and they often have ingredients that help freshen your Pit Bull's teeth. If your Pit Bull won't let you brush their teeth, it's a good idea to give them dental chews on a regular basis to help clean their teeth.
While we've given you some good types of dog bones to choose from and a few specific examples, there are some things you should look for if you choose to find a dog bone for your Pit Bull on your own. Here are some things you should look out for:
Wild dog species like wolves have to work hard to get food, so they eat as much of their prey as possible. That often means gnawing on leg bones once the rest of the meat is gone to get the last little bit of nutrition from the outside of the bone. Once they crack the leg bone open, there's healthy marrow inside that provides crucial minerals.
While today's domesticated dogs get all their nutrition from their food (which they don't need to catch and kill first), they still have that instinctual need to chew. Without bones or bone alternatives to chew on, Pitbulls, like other dogs, will chew on whatever they can, from table legs to your favorite pair of shoes.
Since you can't train out a dog's natural instincts to chew, you need to provide safe items for your Pit Bull to chew on.
While we haven't included any actual bones in this list, these are the best bone alternatives for Pit Bulls that are likely to last longer than other chews when preyed upon by the strong jaws of a Pit Bull. Here are the 5 best bones for Pit Bulls.
About: Bully sticks are one of the best long-lasting chews you can get for a dog, and these long, braided bully sticks will outlast any other kind for your Pit Bull.
Notable Qualities and Features:
User Reviews: While there are occasional quality control problems with stinky sticks or ones that are skinnier than usual, most dogs and people love these sticks. While they still won't last a power chewer forever, they are one of the longest-lasting chews you can get for a Pit Bull that won't break their teeth.
Bottom Line: Don't expect this chew to last more than a few hours, but it's still probably the longest-lasting natural chew you'll find that's soft enough not to risk splintering or injuring your Pit Bull's mouth.
About: For truly long-lasting bones for Pit Bulls, you need to go with something synthetic rather than edible. This chew toy is the best of both worlds, with real maple wood embedded in the nylon chew toy.
Notable Qualities and Features:
User Reviews: Due to its hard plastic texture, some dogs are not interested in this bone. Most dogs, however, love it and it generally lasts a long time. Some dogs are able to break it apart easily, but for most dogs, it lasts quite a while.
Bottom Line: Between its durability and its unique wood flavor, this is one of the best bones for Pit Bulls that love to chew sticks.
About: For a digestible long-lasting chew that isn't meat-based, yak chews are the way to go. Basically a hardened cheese, these simple chews will keep your Pit Bull busy without wrecking their teeth.
Notable Qualities and Features:
User Reviews: While there are occasional reports of quality control issues with bones that are moldy or splinter, most owners rave about these bones. Dogs love them, they last a long time, and they usually don't splinter.
Bottom Line: This is one of the best edible bones you can buy for your Pit Bull. They usually don't splinter, and they typically last longer than other edible chews.
About: Nylabone has been one of the biggest names in durable chew toys for many years, and the Big Chew is no exception to their standard of quality. Designed specifically for extreme chewers, the Big Chew is one of the best bones for Pit Bulls.
Notable Qualities and Features:
User Reviews: Some dogs aren't interested in these hard nylon bones, but other dogs love them, and owners report that the bones are extremely durable. If you have a power chewer, this chew toy is probably the best choice for a Pit Bull.
Bottom Line: If your dog likes hard plastic bones, this is one of the best bones for Pit Bulls on the market. It lasts a long time and generally stands up to even the most powerful chewers.
About: Sometimes you don't want a long-lasting bone for your Pit Bull, but one specifically designed to help clean their teeth. This product fits that bill and is one of the larger dental chews you'll find.
Notable Qualities and Features:
User Reviews: This isn't a long-lasting bone, but dogs love it, and owners report that their dogs have whiter, healthy teeth.
Bottom Line: If you're looking for a dental treat for your Pit Bull, this is one of the best you can get. Just don't expect it to last forever.
Depending on the type of bone or chew, you'll want to give them to your dog anywhere from once a week to once a day. Chew toys are safe to leave out all the time, while bully sticks tend not to last more than a few hours, and dental bones may have a lot of calories. Use your judgment about how frequently to give your dog a bone.
Hopefully, this article has given you some ideas about the best bones for Pit Bulls that will keep your dog safe and happy. Choosing the best bone for your dog may be trickier than you expected, but we've tried to give you all the tools you need to find the best ways to keep your Pit Bull's jaws happy – and your furniture and other valuables safe from their need to chew!
5 Best Safe Dog Bones and Chews for Aggressive Chewers
5 Best Indestructible Dog Toys for Aggressive Chewers
5 Best Dog Foods for Pitbulls (Comparison and Reviews)
Red Nose Pitbull: Breed Facts, History and Differences
Blue Nose Pitbull: A Beautiful Dog with a Mixed Reputation


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- All members should read the Riders Manual - please contact a member of your Executive to get a copy.
1. Biggest rule is to treat all others as though you are their target and act accordingly;
2. Always obey the traffic rules and stop, yield, obey red lights etc, because I can almost guarantee that the other driver is looking at running the red, not yielding, or doing a rolling stop, the only exceptions to this are when there is a Police car clearly evident monitoring the intersection, and sometimes even that is not a guarantee;
3. Beware the left turner, even though they may be looking right at you, for some reason they do not equate the big glaring headlight with a moving vehicle;
4. Always signal when making lane changes and I cannot emphasize enough to do a shoulder check as well;
5. Read the Riders Handbook that was put out by the CAV Road Captain, lots of good tips in it that don't only pertain to group riding.;
6. Treat your ride like it is your second wife, pamper it accordingly, unlike the first wife though, do regular oil level checks, tire inflation and wear checks, and also what a lot DON'T do, light checks, especially turn signal and brake lights;
7. Carry a spare headlight bulb and fuses, but if you do get a failure, try to figure out the reason first, nothing like putting a new fuse in only to have it go again, you run out of fuses quickly, ask me how I know;
8. If you have spotlights on your bike, wire them into their own circuit, that way if the headlight does go out, you will still have the spotlights;
9. Remember it is Spring, and the other drivers are light headed due to the return of warmer weather, they are thinking of the beach, the camping, the cottage, and in some cases the men or women on the beach in all their glory, or in some cases, gory. So their brains are not accustomed to seeing that small object get bigger at a high rate of speed, plus we sometimes tend to get lost in the headlights of the vehicle behind us, so pay attention out there, it hurts when you go sliding down the road or hit hard objects when moving, done both so I know first hand;
10. A couple of tips I have learned from being a Chief Instructor for the Canada Safety Council,
- a. When approaching a vehicle attempting to enter the roadway from your right, move to the right of the centerline if you are not already there, on a multilane highway or road way, move to the left lane if safe to do so, that will give you extra time to react just in case the other driver gets impatient or "fails to see you" ( I hate that phrase);
- b. The same can apply when approaching a vehicle waiting to make a left turn across your lane, this time I would go to the right side of the road, this gives me the extra room to use the roadway as an escape, the chances are that the other vehicle will see you at the last minute and brake, if you are in the part of the lane closest to the centre line, you may have no room or time to maneuver, if you are in the right of the lane you may have time to accelerate and swerve around to your right.
- c. Another point which some will disagree with, is that the first reaction is to grab a handful of brake when faced with a collision situation, that is sometimes your only alternative if you have nowhere else to go, the best method is (if safe to do so) accelerate and go around the vehicle. That is why it is always prudent, if possible, to make sure you do not have a vehicle directly beside you on a multi lane highway, or to take the shoulder if possible on a single lane highway.
- d. Always scan ahead, I try to scan ahead at least 300 metres when traffic permits, while maintaining awareness of what is around you;
- e. Watch oncoming traffic, and don't always think that just because it indicates no passing, that some twit coming at you won't do it, or for that matter someone behind you as well.
- f. Emergency sirens are not a reason to panic, remember the rules is to pull over to the right and stop IF SAFE TO DO SO, I have often not had that option but have slowed down and pulled as far to the right as possible and waved the emergency vehicle past. The wave indicates to the emergency operator that you have seen him and are aware of his presence.
- g. Lastly, have fun out there and don't be paranoid but do be aware, if you are tired, pull over and take a stretch break or stop at a timmies, if you still have a long way to go, consider stopping for the night, better to be rest in a hotel or motel, than a hospital bed.
11. Put together a tool kit and a first aid kit if you can, chances are if you have them you will never use them, whereas if you don't have them, I can guarantee that at some point you will be wishing you had heeded this post and had them.
12. Loose gravel - especially dangerous after winter, like sliding on ice. Also look out for gravel that is thown out into the road by farm vehicles that often will use the shoulder in the country areas. I have also found that country junctions are bad as vehicles will often cut the corner which results in gravel and sand being thrown out into the road, the graders also make a mess. Curves are also a place to watch for.
13. Road kill, always a sign that spring is coming, some of that road kill can be quite big, and remember, as disgusting as it sounds, blood and entrails can be be very slippery and dangerous, especially on corners.


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Mutsumi Toyoshima – A Blueprint for Success
Top Toho Special Effects Designer has Died
Authors: Ed Godziszewski with Oki Miyano
Special Thanks to Yasuyuki Inoue
Mutsumi Toyoshima, widely regarded as one of the best production designers on Toho special effects movies from the 1960s through the 1980s, died November 17.
As a key member of Toho's special effects art department, Toyoshima designed and created blueprints for many of the most famous vehicles, props, and machines seen in the studio's monster, science fiction, and war films. Among his designs are the popular Maser Cannon (introduced in THE WAR OF THE GARGANTUAS in 1966), the Solgell Island silver iodide towers from SON OF GODZILLA (Gojira no Mosuko, 1967), the UN submarine Explorer from KING KONG ESCAPES (Kingu Kongu no Gyakushu, 1967), the Moonlight SY-3 from DESTROY ALL MONSTERS (Kaiju Soshingeki, 1968), the Black Shark from LATITUDE ZERO (Ido Zero Daisakusen,1969), and the Super-X from THE RETURN OF GODZILLA (Gojira, a.k.a. GODZILLA 1985, 1984).
He left Toho in the early 1980s and joined a tourism company called Oriental Land to build Tokyo Disneyland, the first and the most successful Disneyland outside of the US. Toho and Tokyo Disneyland had a very strong connection, and Toyoshima was not the only Toho designer who worked for TDL. After he started work on Tokyo Disneyland, Toyoshima was invited to Anaheim, CA to study the designs of the original Disneyland. Toyoshima stayed with Oriental Land until he completed his work for DisneySea, a new Disney theme park, in 2003.
SciFi Japan is honored to present a tribute to Mutsumi Toyoshima by Ed Godziszewski and Oki Miyano, who knew Mr. Toyoshima and had visited with him in recent years. "I called him while on the train to the airport when I left Tokyo in late October," Oki said. "That was the last time I talked to him. Although I knew him only for four years, he treated me as if I was his nephew. For me, he was like my uncle."
Mutsumi Toyoshima was one of many talented members of the Toho special effects art department who worked on the films of the Golden Age under the tutelage of Yasuyuki Inoue. He attended Musashino Art College in the mid-50s, majoring in art. He entered Toho Studio in 1959, starting out as one of the staff members who took care of sets.
One day, Yasuyuki Inoue offered him the chance to utilize his drawing skills and advance to the position of designer. Toyoshima had experience as a student in drawing blueprints of models, and the Toho staff had a shortage of people who could make good blueprints at that time.
He started out fixing up the blueprints of others, but quickly got the chance to do his own, debuting as a designer on I BOMBED PEARL HARBOR (Taiheiyo no Arashi, a.ka. STORM OF THE PACIFIC, 1960). "To design, you really need to know and understand the 3D view of your subject. For making models of things like ships, it's very different than doing buildings. At that time, Toho had some huge model ships…they were like 10 and 13 meters long, and we would have to modify them or dress them up to pass for the Yamato, Akagi, and so on. For reference, I would go to Kanda [the book center of Tokyo] to find used books and look at the old blueprints in them." It wasn't really possible to use the blueprints of both ships and aircraft from these books since they were shrunken down in size so much, but they provided a useful guideline for Toyoshima.
Toyoshima's philosophy in making blueprints was simple: "Every detail of an object should be put into a blueprint, and you must envision the objects from three sides and then combine them into a single image. It has to be coherent and full of details. The blueprints which we made for models needed to be much more meticulous and detailed than what someone would make for a real building." For Toyoshima, the crucial pieces of equipment for his job were pens. "I had to use pens with a tip diameter of 0.1mm and 0.3mm. If you are not careful enough with your pens, and you draw the lines too thick, the miniatures made from these blueprints would take on a very different and softer look."
Toyoshima often looked to the real world for enhancing his designs and adding details that would be realistic. "One of my most challenging jobs was to design the SY-3 for DESTROY ALL MONSTERS. I would often refer to NASA designs for making my blueprints more realistic. It was my practice to gather a lot of information whenever I had something new to design. One of my favorite reference sources was Popular Science magazine."
"I think that the SY-3 is probably the best work that I have ever done. For that, I used the image of a US military airship as a basis, the kind of plane which was launched from an aircraft carrier. And for the booster engine, I used one of NASA's ideas for that. Thinking of this ship, I thought that to propel it to the moon, the booster section would have to be around 3 times the length of the SY-3 itself. NASA still uses that concept [a booster] today with the space shuttle. The SY-3 was my first assignment after a long absence due to a severe stomach ailment from which I suffered. I wound up designing it in my apartment just after taking a new year's vacation."
As a young man, Toyoshima grew up marveling at the mechanical designs of the famed illustrator Shigeru Komatsuzaki, who also would serve as mechanical designer for Eiji Tsuburaya from time to time. Having a chance to create his own vehicles and mechanisms was a kind of dream job for him. "Ever since I was a kid, I was always interested in mechanical things like bicycles, cars, motorcycles, and so on. I would draw them in detail, and sometimes make my own variations. When I think about designing miniatures for films, it was always a challenge no matter what I was making. If it was something that did not exist, I had to figure out a way to make it look real. If I had to design something that really existed, I would have to be sure to add enough detail so it would look real. Both assignments were really tough."
Although he is credited with designing the Maser Cannon, arguably Toho's greatest and most popular mecha design, Toyoshima actually had less than fond memories of the experience. "First of all, I had to keep the lamp in mind when I designed this. It was the key point of the weapon, so I had to think about how to make it look good. Since the base of this vehicle was someone else's design [the trailer base and barrel were to be recycled from Shigeru Komatsuzaki's designs for the A-Cycle Light Ray for MONSTER ZERO], this job wasn't so enjoyable. I just put the dish on top of someone else's work. I understand it was a budgetary consideration. I wish I could say something better about it or that I liked it, but it's not my favorite. But it did make Takagi [assistant art director Akinori Takagi, who was in charge of engineering the practical mechanical effects] happy since he had to make it functional."
"People might look at it as just a made-up weapon in a monster movie, but we put our hearts into building it. When it worked perfectly on the set it was an emotionally satisfying moment for us."
For LATITUDE ZERO, Toyoshima was pitted against his mentor and boss, Yasuyuki Inoue with dueling submarine designs. Inoue was in charge of creating the Alpha, and Toyoshima got to design the nemesis of the Alpha, Malec's Black Shark. It was an intimidating task for Toyoshima. "The Alpha was very sophisticated, and in comparison the Black Shark looked kind of rough. As an apprentice of Mr Inoue, I wanted to show my talent to my mentor. Hobby Japan commented that it was a match-up of 'mentor vs. apprentice'. And yes, I did have the image of a real killer shark in mind when I made this vehicle."
Mr. Toyoshima took ill shortly after retiring in 2003. He was happier than anyone else when Mr. Inoue was invited to Hollywood in 2004 to celebrate Godzilla's 50th Anniversary at the American Cinematheque and had hoped to come to the States with his mentor. But he couldn't travel overseas due to his poor health.
Toyoshima's creative spirit remained strong throughout his life. "I just love the design process, and I really love all types of vehicles. But making something that does not exist, well that was really the most enjoyable thing of all. In some ways, I am just like a kid. I still call my office the Hobby Studio because I want to keep that dream, just like when I was a kid." Toyoshima was quite proud of his work in the Toho special effects art department, and he felt that working on science fiction films was a real plus. "To make a good design, you have to be interested in the assignment. I loved to create things, make the impossible, create things that no one had seen before. I think this was the key to my success."


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ADF&PCD New York Welcomes Karen Huger of "The Real Housewives of Potomac"
Wednesday, September 05, 2018
Press release from the issuing company
Karen Huger from The Real Housewives of Potomac will be using ADF&PCD New York 2018, North America's only dedicated event for the aerosol, dispensing, perfume & cosmetic packaging and design community, to announce the partnership for her new perfume – 'La' Dame Fragrance by Karen Huger'.
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SOFT99 Neutral Shampoo (Creamy Type)
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If you have created an account and are signed in, you will earn 1 point per whole £ you spend (e.g. spending £9.50 earns 9 points). The redemption value of each point you earn will vary between £0.05 and £0.15 depending on your rolling annual spend; see our loyalty points page for details.


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Status: Open
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At Cynthia's School of Dance & Music, we offer your child more than just a combination of steps to a song. Your children will acquire poise and discipline, but more importantly, confidence in themselves that will carry over into all other aspects of their life. We are your educational dance & music experts. Our teachers make the difference. Come and meet us today. Building confidence in our...
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Why Choose Us Over the past 20 years we at Cynthia's have had the pleasure to teach more than 5, 000 students age 2-92! Our observation windows allow you to watch your child during his/her dance, voice or piano lessons. Our goal as dance and music educators is to bring laughter, fun, music and dance into the lives of young children, teens and adults. An education at Cynthia's builds: * a...
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Cynthia's School of Dance & Music can be found at Mcknight Rd 4721. The following is offered: Dance Studios. The entry is present with us since Sep 7, 2010 and was last updated on Nov 12, 2013. In Pittsburgh there are 32 other Dance Studios. An overview can be found here.
Since 1990, Cynthia's School of Dance & Music have taught more than 5,000 students form age 2 to age 92. The studio's goal as dance and music educators is to bring music, dance, fun and confidence into the lives of children and adults. There are 12 dance classes to choose from and several music programs.


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The most cost effective way to capitalise on open banking
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Sorry, this product is temporarily unavailable or out of season
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Capital works as a cushion against losses and provides protection for members when a credit union is experiencing financial trouble. It follows then that when it comes to measuring an a credit union's financial fortitude, capital is valuable. When looking at safety and soundness, the more capital, the better.
MEDISYS EMPLOYEES received a score of 10 out of a possible 30 points on our test to measure the adequacy of a credit union's capital, falling short of the national average of 15.65.
MEDISYS EMPLOYEES appears to be less well prepared for financial trouble than its peers in this area, with a capitalization ratio of 10.00 percent in our test, less than the average for all credit unions.
Bankrate uses this test to estimate the effect of troubled assets, such as past-due loans, on the credit union's loan loss reserves and overall capitalization.
Having large numbers of these types of assets may eventually force a credit union to use capital to absorb losses, cutting down on its buffer of equity. It also means that there are likely to be many assets that are in non-accrual status and thus aren't earning money, resulting in lower earnings and potentially more risk of a future failure.
MEDISYS EMPLOYEES scored 32 out of a possible 40 points on Bankrate's asset quality test, lower than the national average of 38.09.
The credit union's ratio of problem assets was 0.00 percent in our test, less than the national average and suggestive of greater financial strength than other credit unions.
How successful a credit union is at making money has an effect on its safety and soundness. A credit union can retain its earnings, expanding its capital cushion, or put them to work addressing problematic loans, potentially making the credit union better able to withstand financial trouble. Losses, on the other hand, take away from a credit union's ability to do those things.
MEDISYS EMPLOYEES underperformed the average on Bankrate's test of earnings, achieving a score of 0 out of a possible 30.
MEDISYS EMPLOYEES had an earnings ratio of 0.00 percent in our test, above the average for all credit unions, an indication that it's doing better than its peers in this area.
Bankrate.com's Safe & Sound Ratings provide a star rating system to evaluate the current financial status of financial institutions. The information gathered about banks, credit unions and thrifts is updated as set forth in the Terms of Use of Safe & Sound Ratings and Reports. The Safe & Sound Ratings information is grouped by categories of banks, thrifts and credit unions.
Bankrate.com evaluates the financial condition of institutions and assigns a one- to five-star rating for each with five stars representing the highest rating. Institutions with satisfactory performance will generally receive a rating of three or more stars. The majority of institutions fall into the three- to four-star range. An institution with an "NR" rating may be too new to rate or may have limited the publicly available information in their regulatory filings. The "NR" is not an indication of financial strength or weakness. The Safe & Sound rating is believed to be reliable, but the information is not guaranteed. In addition, events since the information was collected may have altered the institution's financial condition.


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Of all the April Fools jokes I spotted yesterday, this one was the best:
Thinkgeek.com's tauntaun sleeping bag
I wanted one badly! But my mother has already informed me that she cannot buy it for me for my birthday. Why? 1) It isn't real. 2) It's not in my size.
Apparently, the e-reception for the fictitious product was so good that thinkgeek.com is actually considering producing it. Though I doubt they'll really put intestines on the bad-smelling insides.


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Today's Fraud News from around the world: Jury begins deliberations in Paul Manafort's tax- and bank-fraud trial: Jurors began deliberations Thursday in the trial of President Trump's former campaign chairman Paul Manafort, who faces 18 counts of bank fraud and …: Google Alert – Fraud Fraud Has Become the Latest Hurdle for Music Streaming: Fraud is […]
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The City of Ekurhuleni has distanced itself from the bogus 240 litre wheelie bin tender scam scamming people of their hard-earned money. "This is a scam and the city distances itself from it. An investigation is currently ongoing to establish if there is any involvement of the city's officials in this scam. "Entrepreneurship is highly […]


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Philips drives growth in Africa by introducing innovative healthcare and lighting solutions for local markets
Amsterdam, The Netherlands - Royal Philips Electronics (AEX: PHI, NYSE: PHG) announces its third pan-African Cairo to Cape Town road show (from 14th May to 16th August, 2012) to raise awareness on how healthcare and lighting solutions can enhance life in Africa. Philips has been active in Africa for over a century, and has committed to an aggressive multiyear investment plan to significantly increase its business footprint in the coming years based upon locally relevant products and innovations that address the needs of the growing African population.
"We are committed to building a long-term sustainable business footprint in Africa", states Ronald de Jong, Executive Vice President and Chief Market Leader at Philips. "Growth in sub-Saharan Africa is projected to be around 6% in 2012¹ and our ambition is to gain a strong presence in this continent by building on local talent and organizations, setting up distribution and route to market and above all, by developing solutions and innovations which are relevant for the local needs."
In 2010 Philips organized the first Cairo to Cape Town road show. The 2012 version covers 12,000 kilometers across eleven countries and seventeen cities across the continent. During the road show the Philips team will be showcasing its innovations and continues to engage with customers, governments, NGOs and media on topics relating to key challenges facing Africa today: Mother and Child Care, Women's Healthcare, energy efficient LED and solar lighting solutions.
Woman and Child Care focus supporting Millennium Development Goals
The road show continues to build on Mother and Child Care and Women's Healthcare, supporting the UN Millennium Development Goals (MDGs) Goals 4 and 5 aimed at reducing child mortality rates and improving maternal health. Philips provides a broad range of ultrasound, monitoring, clinical informatics and patient care solutions needed to care for mothers and children: from pregnancy, labor and delivery, to postnatal, neonatal and pediatric care, and the transition to home.
Clinical education strengthens success of the road show
Philips is delivering customized training modules around Mother and Child Care in all markets during the road show. "Education is really key, and that's why we have a strong emphasis on clinical training throughout this road show", says Juan van Dongen, Vice President and CEO Philips Africa. "It's one thing having the equipment, but we are also committed to enabling clinicians to use it, through dedicated clinical education. While we work to develop the most intuitive systems possible, clinicians may still require tools that will help them better interpret fetal heart traces for example."
Philips LED lighting offering key benefits to Africa
During the road show Philips also highlights the benefits of LED lighting, which offers solutions to some of the key issues and opportunities Africa faces today: energy efficiency, climate change, resource scarcity, safety in cities, productivity in offices, and an enhanced sense of health and well-being. New LED technology, when combined with the latest solar and battery developments, can also provide good quality practical light for rural areas where more than 500 million Africans currently live without electricity. Philips will be promoting its new solar powered LED Street and Area lighting solutions which offer cost effective and reliable illumination. A Pan-African soccer tour under solar-powered LED floodlights is also planned to highlight these developments.
"We have already been in Africa for many years and have a strong installed base of our equipment, but we strongly acknowledge the benefits of dialogue during this road show and the need for our company to listen to the local market and understand how we can adapt our products to better serve this continent", Ronald de Jong summarized.
The road show kicks-off in Cairo on 14th May and will make its next stop in Alexandria on 17th May 2012, and ends in South Africa on 16th August.
For more information please follow the Cairo to Cape Town roadshow on:www.philips.com/africaroadshow
Note to the editors:
Philips will participate in the World Economic Forum on Africa Meeting taking place 9th-11th May 2012, in Addis Ababa, Ethiopia. A delegation led by Juan van Dongen, Vice President and CEO of Philips Africa, will explore possibilities to improve the quality of healthcare, lighting and citizen's well-being in Africa through better access to innovative and sustainable solutions, infrastructure, education, sharing of best practices and improved collaboration between public and private stakeholders.
¹ The International Monetary Fund (IMF) - Regional Economic Outlook : Sub-Saharan African.http://www.imf.org/external/np/sec/pr/2011/pr11366.htm
For further information, please contact:
Radhika Choksey
Corporate Communications
Philips International B.V.
Tel: +31 62525 9000
E-mail: firstname.lastname@example.com
About Royal Philips Electronics
Royal Philips Electronics of the Netherlands (NYSE: PHG, AEX: PHI) is a diversified health and well-being company, focused on improving people's lives through meaningful innovation. As a world leader in healthcare, lifestyle and lighting, Philips integrates technologies and design into people-centric solutions, based on fundamental customer insights and the brand promise of "sense and simplicity." Headquartered in the Netherlands, Philips employs approximately 122,000 employees with sales and services in more than 100 countries worldwide. With sales of EUR 22.6 billion in 2011, the company is a market leader in cardiac care, acute care and home healthcare, energy efficient lighting solutions and new lighting applications, as well as lifestyle products for personal well-being and pleasure with strong leadership positions in male shaving and grooming, portable entertainment and oral healthcare.www.philips.com/newscenter.