text:
Hi everyone,
Hard to believe we're already more than a third of the way through the year, isn't it? Where has the time gone? Hope the new spring season at least is meeting all your expectations. My wife and I have both been enjoying Ore Monogatari (a.k.a. "My Love Story") lately. It's a shoujo love story with a male lead, and it's probably one of the most heartwarming anime we've seen in a long while.
Just a reminder that if you haven't already read the blog post I made about these things last year, "On submissions, approvals, and comments", you should really go do that. It includes important information regarding rules changes and updates here on AnimeShinbun. These issues can and will impact on your eligibility to win prizes. You can find the blog post at the following URL.
How many stories can you submit? Every news story you submit on AnimeShinbun during the month will get you 1 entry, and we'll be picking 3 winners at random from those entries. The more times you submit stories, the greater your chance to win!
Prize: 3 winners, receiving a $50 Amazon Gift Card each!
Pretty much self-explanatory this one. Each and every comment you make on AnimeShinbun (regardless of if that's in a news story or blog) during the month will net you an entry in this competition. And to make things interesting...we'll give you entries for every tip you contribute as well! So no excuses for not contributing those extra stories now when you hit your news submission limit. ;)
Prize: 1 winner, receiving a $50 Amazon Gift Card!
As usual with all of our contests, you'll be disqualified if you pick up a restriction of any kind during the contest period, or if it comes to our attention you've broken rules for posting and approving submissions that month (regardless of if that led to you being placed under a restriction or not). Comments with negative labels (Trolling, Off Topic, etc.), unresolved reported stories, etc, will not count to any competition.
In the interests of fairness, each entrant will only be eligible to win one prize per month. If your name comes up for multiple prizes, then we'll be awarding you the highest value one and redrawing the others.
Terms and Conditions
1. Competition is open to all AnimeShinbun users, except for employees of HAVAmedia and immediate relatives. Contests are NOT limited to the US/North America.
2. Closing date is 11:59 PM (American Pacific Standard Time), May 31st 2015.
3. In the event of unforeseen circumstances AnimeShinbun/HAVAmedia reserves the right to substitute prizes for alternatives of equal or greater value.
4. Prizes are not transferable.
5. The winners of the competition will be notified by AnimeShinbun ticket on or before June 7th, 2015.
6. Failure to reply to ticket notification within seven (7) days will result in forfeiture of prize.
April 2015 Contest Winners
Alxe, Alixithymia, HystericalGamez, paradigmfellow
Ore Monogatari, I'm unfamiliar with that one, I'll have to check it out!


text:
Great job lot of wedding decorations to help anyone decorate a DIY wedding at more half the price I paid for them originally. We had a very relaxed, bohemian marquee wedding and all the decorations worked together perfectly. Below I have listed everything you will receive in this job lot of wedding decorations. 8 handmade lace dream catchers in various sizes with pink and white ribbon and some with pink flowers.
These took me hours to make so I hope you love them as much as I do. 5 large glass cylinder pillar candle holders with glass bases.
5 outdoor battery operated pillar candles included. 2 large pale gold glass lanterns. 4 Gold recycled (were filled candles originally and I removed the leftover wax so they can hold a tea light or votive candles) candle holders. 15 decorated (by me) jars and candle holders. 8 colourful glass bottles with cork lids - could be used as bud vases for individual flower stems (new and unused).
Gold Mr & Mrs cake topper. Mr & Mrs chair plaques handmade made by me :- - ribbons attached for hanging. 19 clear glass t light holders (I think the 20th mustve got left behind at the venue).
2 rustic wooden standing hearts. White and mirror cake stand (new and unused) - the cake lady got her wires crossed and ended up making us a tiered cake so the cake stand was unsuitable which is why it is unused.
Small bunch of pink and white fake flowers. Set of 3 Sass & Belle floral suitcases - I used one as the card box and the two smaller ones to hold the confetti. 6 lengths of floral bunting - each length is 3.8 metres. 8 white honeycomb heart Pom Poms in 3 different sizes.
13 (11 shown in photo but there are 13 in total) Gold lantern candle holders with rope handles. Large white wicker heart with ribbon attached for hanging. 8 clear dome umbrellas (new and unused) - we were very lucky enough to get perfect weather on our big day so we didnt need them :.
Please let me know if you have any questions. The item "Wedding Decorations Job Lot Used Candle Holders Cake Topper Pom Poms Lanterns" is in sale since Wednesday, June 6, 2018. This item is in the category "Home, Furniture & DIY\Wedding Supplies\Venue Decorations".The seller is "shellc86" and is located in Crewe. This item can't be shipped, the buyer must pick up the item.

subset: commoncrawl


text:
New Week Quotes to Keep You Motivated
As soon as you make it to Friday, it seems like Monday rolls right back around. You dive directly into another 40 hours of answering emails, attempting to appease clients and gulping subpar coffee. It can be difficult to stay motivated in the midst of the daily hustle. You might even forget why you went into your field in the first place. That's where new week quotes come in handy.
Sometimes, the philosophy of "mind over matter" is a particularly helpful one. When you encounter another Monday and feel ill-equipped to make it through the week, turn to one of these new week quotes for inspiration.
1. "Don't count the days; make the days count." – Muhammad Ali
No one knew the sweet feeling of victory or the bitter taste of defeat quite like legendary boxer Muhammad Ali. Despite the fact that he didn't win every match, Ali recognized that he was still a winner when he approached every day as an opportunity to change the world for the better. That's why Muhammad Ali's personal mantra leads this list of new week quotes.
2. "Believe you can and you're halfway there." – Theodore Roosevelt
President Theodore Roosevelt didn't let his childhood, which was plagued with illness, keep him from achieving his ultimate goal of leading the nation. He believed he could attain any goal he set his mind to — and you can, too.
3. "Nothing can stop the man with the right mental attitude from achieving his goal. Nothing on earth can help the man with the wrong attitude." – Thomas Jefferson
Likewise, Founding Father Thomas Jefferson knew that the difference between a positive and a negative attitude could be the difference between conquering a goal and buckling under the pressure. Despite his massive responsibilities to the nation, Jefferson remained optimistic.
4. "Keep your face to the sunshine and you can never see the shadow." – Helen Keller
Just the fact that Helen Keller could speak a motivational quote is an inspiration in itself. It was Keller's perseverance and sunny disposition that allowed her to eventually learn to speak, and both aspects of her personality shine through in this uplifting quote.
5. "My mission in life is not merely to survive, but to thrive; and to do so with some passion, some compassion, some humor, and some style" – Maya Angelou
Maya Angelou reached millions of people with her poetry, essays and other written works before she passed away in 2014. This soundbite should help remind you that this week is your chance to find your passion and be kind to others, just as Angelou always strived to do.
Want to be more productive?
Learn how to be more with Productivity Theory's weekly newsletter!
Join 2,000 other subscribers now!
6. "Life is not easy for any of us. But what of that? We must have perseverance and above all confidence in ourselves. We must believe that we are gifted for something, and that this thing must be attained." – Marie Curie
Famed scientist Marie Curie didn't pull any punches. She recognized that life could be dreary at times, but she also knew that every day had a purpose, and she lived to fulfill that purpose. Can you say the same for yourself today?
7. "Whether you think you can or you think you can't, you're right." – Henry Ford
Another fan of the mind-over-matter approach, automotive mogul Henry Ford always operated under the belief that he could achieve any goal he created. His professional success indicates that he was onto something.
8. "Twenty years from now you will be more disappointed by the things that you didn't do than by the ones you did do, so throw off the bowlines, sail away from safe harbor, catch the trade winds in your sails. Explore, dream, discover." – Mark Twain
Mark Twain was a free spirit, and his well-known quote reflects that. Do you still seek to dream and discover on a daily basis?
9. "I would rather die of passion than of boredom." – Vincent van Gogh
Van Gogh was driven by a passion for his art, and innate passion probably drove you to pursue your vocation, too. Try to remember what landed you in your current position and reignite that passion at the beginning of this workweek.
10. "How wonderful it is that nobody need wait a single moment before starting to improve the world." – Anne Frank
Anne Frank had every reason to lament the state of the world, yet she found hope in every new morning. Her optimistic approach might just help put things in perspective for you this week.
Now that you have a few new nuggets of wisdom to inspire you, it's time to get to work. Jot down your favorite quote and hang it in your cubicle to remind yourself what you're working for when the Monday morning blues hit!
If you enjoyed this post, you'll also like these:
- 5 Ways Being Effective at Work Makes You Smarter
- 5 Business Productivity Softwares to Level Up Your Team's Efficiency
- How to Do Work When You're Tired
- Strategic Planning and Goal Setting Ideas for Businesses in 2020
- How to Automate Your Emails
- How Does Being Efficient in the Workplace Increase Your Effectiveness?
- How to Work While Traveling: 7 Productivity Hacks
- 16 Quotes from Successful People on How to Increase Your Productivity
- 7 Tips and Tricks for Getting Used to Working From Home
- How to Automate Repetitive Tasks in Windows
Latest posts by Kayla Matthews (see all)
- 15 Best Ways to Work From Home Part-Time - April 3, 2020
- Productivity Apps and Hacks for Your Android - March 29, 2020
- 5 Ways Being Effective at Work Makes You Smarter - January 29, 2020
Leave a Reply
This site uses Akismet to reduce spam. Learn how your comment data is processed.
This site uses Akismet to reduce spam. Learn how your comment data is processed.


text:
Year: 2018Genre: Talk-ShowDescription:
A monthly talk show in which legendary late-night host David Letterman interviews fascinating global figures in depth. Each 60-minute episode will feature conversations between Letterman and an iconic guest both inside and outside the studio setting, with field segments filmed at locations far and wide depending upon the featured guest.
|Seasons My Next Guest Needs No Introduction With David Letterman


text:
We at the lonebiker.com would like to sincerely apologize to everybody as there will be no beer review this week .
The lonebiker.com understands that this may cost the breweries millions of dollars in lost revenue but this is a choice they must make as it`s top reviewer is down with a severe cold . We hope to be back next week (God help us) if he makes it . Thelonebiker.com understands that in his poor condition he will make unfair and unruly decisions that may alter the face of beer forever !
Goodbye for now and pray for the lonebiker as it seems he is just one incredibly big pussy .


text:
IRIS. Documentary with Iris Apfel, Carl Apfel, and Albert Maysles. Directed by Albert Maysles. Rated M (Coarse language). 75 min.
Iris Apfel is a famous fashion icon, who is resident in New York and over 90 years of age. In this highly enjoyable and fascinating documentary, she is interviewed, photographed, and directed by Albert Maysles, who was over 80 at the time.
Iris has a huge zest for life ("when she is not busy, she gets depressed"), an unbelievable sense of high style (for me, Iris says, "it is not intellectual; it is all gut"), and she is liberally endowed with a curious mind and a witty, cheeky sense of humour. She lives with her ailing husband, Carl, who lovingly shares her "assorted madness".
Iris began life in the fashion industry as an interior designer. Born in 1921 to Jewish parents in Queens Borough, New York, she quickly developed an unique sense of style. She talks of a mother, "who worshipped at the altar of the accessory", and her style is captured in the movie by showing her wearing huge glasses, swept-back hair, massively chunky jewellery, and bizarre-looking clothes. Iris mixes clothes that she finds in thrift stores - including embroidered cloths, patterned shoes, religious vestments, and virtually anything else that appeals to her. For Iris, colour reigns supreme. She never dresses boringly, and is widely regarded as a legendary collector of fashion, who found fame late in life for outrageous dressing.
Iris became in her own words, a "geriatric starlet" when the Metropolitan Museum of Art in New York staged an exhibition of her work, titled "Rare Bird of Fashion: The Irreverent Iris Apfel", in 2005. She has been a consultant to various inhabitants of the White House, and is known for "having a problem" with Jackie Kennedy. Her work currently is featured in the White House, and in major collections around the world, and she helps students learn about the fashion industry.
In this documentary, Albert Maysles follows Iris everywhere - sharing her conversations with him and other people, celebrating her appearances on television, and being with her at home and while she is travelling and shopping for accessories. He is well known for other documentaries on eccentric people, such as "Gimme Shelter", 1970 (about the Rolling Stones), and "Grey Gardens", 1976 (about two of Jackie Kennedy's unusual relatives). He died in March, 2015, aged 88.
No one can make a movie about Iris, without becoming absorbed totally in the "statement" she chooses to make. Iris captures the viewer's imagination from the moment she first appears, and she holds it. In most scenes she is oblivious to those around her and to passers-by, and she always dresses in an extraordinary way.
The documentary is directed, photographed and arranged with an excellent eye for detail by Albert Maysles. He edits tightly and paints a vivid portrait of Iris as a complete eccentric. He composes his scenes thoughtfully, and chooses to let her flamboyance speak for itself. The documentary is a heart-felt, intimate display of Iris' total nonconformity. Maysles makes sure that the importance of "style" is always emphasised for the viewer, and there is never any doubt that he loves Iris's rare fashion sense, the complete oddity of her life, and her undisputed creative flair.
There are conversations in this documentary on weighty issues like the relationship of the clothing industry to politics, history and science, the impact of ageing, and the fickleness of high couture fashion. Maysles chooses to concentrate nearly all the time, however, on a flattering portrait of Iris. The film is a warm, deeply personal picture of a fascinating woman who has lived and aged well, and who obviously loves being celebrated as someone completely different from anyone else.
This documentary doesn't convey profound truths or earth-shattering ideas. Rather, it is a film that celebrates gloriously the eccentricity and individualism of Iris Apfel. Iris is ageing, immensely talented, funny, and intellectually alive. She may be too creative to be a role model for most, but she is an inspiration for those who strive to look, and be, very different.
Peter W. Sheehan is Associate of the Australian Catholic Office for Film and Broadcasting
Madman Entertainment
Released August 13th., 2015


text:
Rangdum to Lamayuru Trek
Ladakh | 10D/9N | 17,241 Ft.
July to October
(Above mentioned cost is for a fixed departure)
- Reviews 3934.9/5
- Vacation Style High Altitude Trek
- Activity Level Difficult
- Group Size Medium Group
All about the Rangdum to Lamayuru Trek.
The trek from Rangdum to Lamayuru follows the most offbeat trail in Ladakh, rendering it ideal for those who wish to avoid the beaten tracks. The trek plunges into the remotest valleys of Ladakh, and through three different mountain passes. Rangdum is a beautiful high altitude plateau that lies in one of the most isolated areas of Suru Valley, almost right between Kargil and Padum. Fenced by magnificent hills and glaciers, the elliptical plateau is the origin point of the trek. Owing to the isolation from the common regions of Ladakh, the trail is trodden by only handful trekkers, who wander here seeking out the haunting beauty of the untouched nooks of nature. Besides breathtaking beauty, you also get to visit some of the themes ancient and beautiful Buddhist monasteries. The splendour of Ladakhi villages magnifies your experience twofold.
Max. Altitude – 5,246 m
Duration – 10 days
Level – Difficult
1. The trek traces one of the most offbeat trails in Ladakh and offers you the kind of solitude, respite, and peace you need.
2. Be privy to the beautiful blend of Buddhist and Tibetan cultures that is exclusive to Ladakhi villages.
3. Traverse the remote but beautiful parts of Suru valley, carrying a backdrop of stunning glaciers and mountains.
Rangdum to Lamayuru Detailed Itinerary
Day 1 : Drive from Leh to Kargil
Day 2 : Drive from Kargil to Rangdum
Day 3 : Trek from Rangdum to Junction
We date a short detour to the beautiful Rangdum Monastery before actually beginning the trek. Then, we head towards the junction, following a gradual, easy trail that unfolds right beside a gurgling river. After about two hours, we reach the junction a beautiful campsite near the river, where we pitch our tents and camp for the night.
Distance: 13.5 km
Time Taken: 4 – 5 hrs
Day 4 : Trek from Junction to Kong Nala via Kanji La Pass
A splendor long trek today. We leave the campsite at junction, and trace the path flanking the left side of the gorge, which ascends to the Kanji La Pass. The climb to Kanji La is gradual, and once at the pass, you're treated to mind-boggling views of the surrounding Ladakhi Himalayas, dominated by the mighty Nun Kun peaks. Spend some time admiring the beauty, and drinking in the sweeping views of Ladakh, and start descending to the River Kong Nala. This will be our campsite for the night. Stay in tents.
Distance: 11 km
Time Taken: 6 – 7 hrs
Day 5 : Trek from Kong Nala to Kanji
We continue post a hearty breakfast. The trail unwinds beside yet another gurgling river, and massive rock walls and mountains loom into view. The view is strikingly different from the ones you've seen so far. Admire the beauty of the view as you approach Kanji, a quaint little village with beautiful views. Stay here will be in a homestay.
Distance: 13 km
Time Taken: 4 hrs
Day 6 : Trek from Kanji to Shillakong via Yokma La Pass
Like the first pass day, this one will also be a bit long. We begin after breakfast, and trek through a bridge that opens up along the river's left side. Follow the trail that hugs the gorge, and begin ascending to Yokma La Pass. The climb is gradual, and you are rewarded with spectacular views of the Himalayas, yet again. Explore around for a while, and start descending to Shillakong, our campsite for the night.
Distance: 12 km
Time Taken: 6 – 7 hours
Day 7 : Trek from Shillakong to Hanupatta via Nyigutse La Pass
The longest day of the trek. We begin early in the morning, as maintain a steady pace, as the altitude gain is considerable, and the trail is a bit challenging. The climb to Nyigutse La is a steep one, as well as a long one. But the pass leads to views magnificent enough to pale all your exhaustion. Admire the views for a bit, and then begin descending to the rustic village of Hanupatta. Overnight stay in a homestay.
Distance: 19 km
Time Taken: 9 hrs
Day 8 : Trek from Hanupatta to Wanla
A relatively short day today. We begin trekking along the river, and past the Phenjila village. Once we pass the village, we soon reach Wanla village, where we stay overnight in a homestay.
Distance: 18 km
Time Taken: 5 hrs
Day 9 : Trek from Wanla to Lamayuru via Prinkti La Pass
Last day of the trek today, and a short one. We stick to the trail tailing the gorge, and climb up to Prinkti La Pass, a window to mesmerising vistas of the landscape of Ladakh. After spending some time admiring and exploring around, we begin descending to the Lamayuru Monastery. This officially marks the end of your trek. Vehicles can be arranged from here to take you back to Leh.
Distance: 9.5 km
Time Taken: 4 – 5 hrs
Day 10 : Drive from Lamayuru to Leh
The tour package inclusions and exclusions at a glance.
- Accommodation: All accommodation on the trek will be on twin sharing basis in Tents or Homestays. Any accommodation in a hotel/guest house/hostel (if mentioned in the itinerary and not mentioned in exclusions) will be in a 2-3 star accommodation unless mentioned otherwise.
- Trek Leader and Guides: A team of an experienced and certified Trek Leader, as well as a professional guide, will accompany you for the trek.
- Services of a Professional Trekking Team: A team of an experienced Cook, Camp Staff, Porters/Mules will accompany you for all the arrangements on the trek.
- Meals: All Meals on the Trek are included. We will serve Vegetarian Indian food on the trek which will be cooked by our high altitude chefs. It will be a five meal plan including Morning Tea, Breakfast, Lunch, Snacks and Dinner. You will be provided with clean mountain water from the streams to drink. You can carry water purification tablets if you deem necessary but we advise otherwise.
- Trekking and Safety Equipment: All the camping equipment such as Tents, Sleeping bags, Toilet Tents, Dining Tent, Mattresses, and other things will be provided by us and we guarantee the quality. Safety Equipment including Medical kit, Oxygen Cylinder, Oximeter, Crampons & Gaiters(if required) will be provided by us. We recommend you to bring your own sleeping bags if possible.
- Permits and Forest Camping Charges: Only for Indian Clients, All the applicable trekking permits, Camping Charges, Forest Entry Fee etc will be paid by us. Foreigners have to pay these charges if not mentioned.
- A Life Changing Experience: We assure you that by trekking in the Himalayas you will have a life changing experience and we will do everything we can to provide you with the best services and make your venture in the wild an unforgettable one.
- GST and Other Taxes: The goods and services tax is not included in the price mentioned with the trek. They will be charged once you add the trek in your cart. They are subjected to change according to government rules of India.
- Accommodation and Food in Leh: Food and stay in Leh are not included in the package. You can book your hotels or homestays in Leh, we can recommend a few good options.
- Flights and Transportation: Flights or other means of transport is not included in the package. Transportation from home to Leh and vice versa is not included in the package. We can arrange a cab for you according to your requirements but you will be liable to pay for the same. Any expenses occurred during the journey are not included in the package cost.
- Personal Trekking Equipment: Your Rucksack, personal clothing, shoes, trek poles, and other personal trekking gear is not included in this package. You have to bring your own gear according to that weather and difficulty of the trek.
- Portage of Personal Bags(Offloading): We highly advise you to carry your own burden (your rucksack) but due to any reason if you wish to not carry your rucksack, we can arrange for a porter/mule to carry it. For this service, you will be charged over and above the trek cost. The charges for offloading vary with every trek.
- Travel Insurance: Travel Insurance is not included in this package. We recommend you to have travel insurance before opting for such adventures.
- Personal Expenses: Any personal expenses incurred (laundry, Bottled Water, Beverages, snacks, orders tea houses or dhabas, Tips for guides etc) are not included in the package.
- Emergency Expenses: Any costs arising out of unforeseen circumstances such as accidents, bad weather, landslides, road conditions and any other circumstances beyond our control are not included in the package.
- Anything not mentioned in Inclusions of the package.
FAQs and Reviews
Whom is the trek for?
The level of this trek leans more towards moderate level of difficulty, which naturally demands exceptional physical fitness, stamina and endurance. It is strongly advisable to have prior trekking experience of scaling at least 3,500 meters before you approach this trek, which means beginners should stay away. Also, proper acclimatization is key for successful completion of the trek.
When should the trek be attempted?
July to September is an ideal season for this trek, as the weather conditions are considerably more pleasant and stable, as opposed to harsh winters.
How to reach Leh?
By Air You can take a direct flight to Leh from Delhi, Mumbai and Srinagar. Take a cab to the base camp from Leh Airport. By Road You can reach Leh by road either from Srinagar or from Manali, although the Srinagar route is widely preferred over the Manali route. By Rail Jammu Tawi is the nearest railways station to Leh, and is well connected to most major cities like Delhi, Mumbai and Chennai.
What things are needed to be carried?
Rucksack, high ankle trekking shoes, one fleece jacket, one down feather / hollofil jacket, 3 pairs of quick dry T-shirts and trek pants, 5-6 pairs of socks, balaclava, a day pack, sunscreen SPF 50+, scarf, towel, lip balm, headlamp / torch, 2 water bottles of 1 litre, and personal medicines. For complete checklist, download the checklist from the footer.


text:
Project country: United States
Project location: New York City
Architect: Gensler / Diller Scofidio + Renfro
Structural engineer: Leslie E. Robertson Associates
Executing company: Sciami CM / Difama Concrete
The Columbia University Medical Center is a state-of-the-art medical and graduate education building that reflects how medicine is taught, learned, and practiced in the 21st century. Designed by Diller Scofidio + Renfro in collaboration with Gensler as the executive architect, this 14-story glass tower interweaves technologically advanced classrooms, collaboration spaces, and a modern simulation center.
The building's structural spine is a site-formed reinforced concrete vertical core, which provides shear capacity. In the cascade, there are reinforced architectural concrete columns with embedded steel-up girders. Post-tensioned, reinforced concrete slabs with embedded structural steel and Cobiax void formers enable the long spans and cantilevers of the south facade.
The building was awarded LEED Gold for sustainable construction. Environmental technology such as fixed and operable shading optimizes the regulation of daylight and sunlight and an innovative mechanical system that maximizes comfort, while at the same time reducing the energy and water consumption in the building. Green roof technologies reduce the heat-generating effects of urban asphalt and concrete, decrease building energy consumption, and recycle stormwater runoff. Native plantings adapted to the area's sun and wind conditions minimize irrigation requirements and produce year-round texture, color, and shelter. LEED, or Leadership in Energy and Environmental Design, certification is a globally recognized symbol of sustainability achievement.
Image 1: © Cobiax USA Inc. | Images 2, 3: © Pavel Bendov
The modular product line for international use, thanks to the half-shell technology. This line of products enables effective transport and easy assembly.Learn more.
Barmelweid is expanding in order to be able to accept all patients in the future.Learn more.
Improved: Assima Project – The largest commercial building in Kuwait CityLearn more.
The Cobiax history is one of safe, sustainable and profitable innovations in the building industry: it is rich in ideas and assertive, and it is being used extremely successfully, worldwide.
A story that is having a considerable effect on the building methods of the 21st Century.Learn more.
At the beginning of every pioneering development, there are visionaries who turn theoretical possibilities into reliable technology. And strong people who are able to draw their will to succeed in the practical implementation of ideas, from the powers of possibility.
Never miss out on any news again. Click on the button below to register for our newsletter.Cobiax Newsletter.


text:
From John Adams to James Searle, 26 December 1781
To James Searle
Amsterdam Decr 26. 17811
Dr Sir
Your two favours of Decr 3 and that of December 14, are before me.2 Mr Barclay is arrived, to my great Relief: His office and Character as well as your Recommendations entitle him to every Respect and Civility from me.
You favour from L'orient I answered, and transmitted under Cover to Mr Cummings, Some Dispatches from Gover Read. I condole with you, under the Loss of Mrs Searle:3 But Such is the Constitution of the World, and Under the Loss of Friends Fortunes, &c all We have to do is to Submit. Your Resolution to Spend the Remainder of your Days in Europe, may not prove to be a Law of the Medes,4 whether, however in Europe or America, I wish you success and Prosperity.
Mr Bondfield has acted hitherto, for the Public at Bourdeaux, and has ever behaved well, as far as I have known. I Suppose that he will expect to be continued in the Service and to be Vice Consul or Consul, if Congress should appoint Such an officer for that Place. But perhaps Congress will, not appoint any but the Consul General and leave him to employ Such Persons as his Agents in other Cities as he pleases.
The Secretaryship for the Mission to Versailles, I am convinced will never be filled up, while the present Minister lives, unless it should be with the young Gentleman.5 The Commission for Peace is new modelled. The Ministers to Versailles and Madrid, Mr Laurens in the Tower and Mr Jefferson in America, are added in the new Commission: and there is no Secretary appointed. Mr Dana, is Still at Liberty to Act in it, in certain Circumstances, which however will not happen, because the Commission itself will not be called to Act a long time.
Portugal is but an English Colony, and never in my opinion will have any Thing to do with america while the War lasts. Thus you See, that I have no great Expectations, of your Succeeding in any Thing of a public Nature in Europe at present. Your Wish to be Vice Consul or Consul in Case another Should be appointed, is modest enough to be sure but you know that Congress have always many applications, and they weigh the Pretensions of all, very carefully. Your appointment would be very agreable to me, but all I can do in it, is to mention it to some of my friends. <
But you know that my particular Friends in Congress are influenced by nobody, and no Consideration but the public good.>
As to your Sic Vos non Vobis Vellera fertis oves.6 It is true that I am a sheep and that I have been fleeced, but it gives me some Pleasure to reflect that my wool makes others warm. No I had rather Say I am a Bird, that my feathers have been plucked and worn as ornaments by others. Let them have the Plumage if they will it is but a Geugaw. However away with all this. It would be more just to say that We are all too much Addicted to disputing for the Feathers before We are quite in Possession of the Bird.
What do you mean by Ebenezer Kennersley?7 I dont Understand you. Your Sprightly Wit is a Proof to me that your Health is better, and it has a friendly effect upon mine.
I am with much Esteem, your Frd & hul sert
LbC (Adams Papers).
1. The recipient's copy of this letter was intercepted when the brig Betsey, bound from Nantes to Philadelphia, was captured and taken into New York (New York Royal Gazette, 3 July 1782). The letter was printed in the Royal Gazette of 10 July. A copy of the letter as reprinted in the Philadelphia Freeman's Journal, 7 Aug., is in the Adams Papers (filmed at 30 April 1782, Adams Papers, Microfilms, Reel No. 356). When JA published this letter in the Boston Patriot, 12 Sept. 1810, he noted, "this insignificant letter was intercepted by the enemy, and the ministry thought fit to print it in the newspapers; no doubt with the generous design of exciting miffs among Americans. Among those seized at St. Eustatia were some of more importance, but those they carefully suppressed."
2. Neither of these letters has been found.
3. Ann Smith Searle died on 23 Sept. (Pennsylvania Gazette, 17 Oct.).
4. JA may be referring to Daniel, 6:15, "Know, O king, that the law of the Medes and Persians is, That no decree or statute which the king establisheth may be changed"; but similar statements appear in Daniel, 6:8, 12, and Esther, 1:19.
5. William Temple Franklin.
6. That is, you sheep have fleeces not for yourselves (attributed to Virgil).
7. Presumably Rev. Ebenezer Kinnersley, Baptist minister and Franklin's friend and associate in his electrical experiments (DAB description begins Allen Johnson and Dumas Malone, eds., Dictionary of American Biography, New York, 1928–1936; 20 vols. plus index and supplements. description ends ; Franklin, Papers description begins The Papers of Benjamin Franklin, ed. Leonard W. Labaree, William B. Willcox (from vol. 15), Claude A. Lopez (vol. 27), Barbara B. Oberg (from vol. 28), Ellen R. Cohn (from vol. 36), and others, New Haven, 1959– . description ends , 4:192). Without Searle's letter, the meaning remains unclear.


text:
About Us
Coronavirus Update
- Sprays
- Hand tied Bouquets
- Container arrangements
- Funeral tributes
- Full wedding service
- Seasonal gifts
With over 30 years of experience in both retail and wholesale floristry, Sam and Lorraine always puts the emphasis firmly on quality, design and originality.
New Beginnings Florist personal delivery service covers a wide area of Norfolk and Suffolk. For deliveries further afield their registered Teleflorist UK membership is able to meet all your UK and worldwide delivery requirements. New Beginnings also provide an extensive range of funeral tributes and home visits to the recently bereaved are also available.
You can order online by clicking on shop above or by looking at any of our collections or if you have any questions then please contact in the shop on 01986 896404 or 0800 542659
Please get in touch or Call Now on 01986 896404 or 0800 542659


text:
Card #1:
Card #2:
Card #3:
A new blog has hit the streets- A Blog Named Hero. It's a challenge site dedicated to all things Hero Arts. SO far, it seems like a really fun site, and I created this little card set for their first challenge!
this stamp, Mr. Huey's - Piglet, Sunshine and Bonny Blue, Black StazOn Ink
Thanks for stopping by, talk to you soon! M.


text:
These tips are for the work place, but they work at home too!
1. Send a little present
A bit disappointing when you have not received anything from your significant other, isn't it? Make sure you meet your expectations, or better, exceed them! Flowers for when you started a big project together or a present at a lustrum party can do a lot!
2. Keep showing attention
Remember that fantastic project you had last year with that customer? And how often do you speak with them now? Even when you do not work close together anymore, make time for a call or a cup of coffee.
3. Surprise
Be thoughtful and give a small gift. Not only when you have to fix something or at special occasion, but just because you can. A smile or compliment work well too.
4. Make eye contact
Truly be there for your customer. Do not think about what you want to say or how your solutions fit in the story of your customer. Just listen. Try this at home too.
5. Personal preferences
Remember your customer's preferences: his favorite coffee or the way you send your information: email or hard copy via snail mail. A little test: how many preferences can you mention about your key clients?
6. "How was your day, sweetie?"
But then the business equivalent of it. Show interest in the personal life. How are your kids, did you win your soccer match last weekend? Where are you going on your holidays? When you see your client the next time, ask: how was little Timmy's first school day? You recovered from that aching knee already? How was Italy?
7. Mixtape
Play music your client recognizes, show their corporate movie or get products in their company color, or even from their brand.
8. Match
It's important for your client to feel that there is a match between himself and the organization. Go ahead and find simular interest, same opinions about matters in your business and learn from each other.
9. Flirt
Without getting corny (or scary): flirt a little! Make compliments, show interest, laugh together. It's nice. What will you do to make your colleagues and clients feel special? Share your thoughts in the comments!


text:
Resolution (f16)
Performance at f16 (Zone A: centre frame)
|Canon 24mm L / f16 centre frame
|Zeiss ZF 25mm / f16 centre frame
0 points
1 point
Allowing for both lenses being well over the hill at f16 for centre frame sharpness, both designs are commendably delivering most of the f8 goodness still. The very pernickety may agree that the ZF25 still looks cleaner.
Performance at f16 (Zone B: upper right)
|Canon 24mm L / f16 mid frame
|Zeiss ZF 25mm / f16 mid frame
0 points
1 point
Barring subtly different styles of presentation, these are now very similar. The slightly higher contrast levels of the Zeiss are clarifying details in the brickwork not evident in the Canon shot, so it just deserves the extra point.
Performance at 24mm: f16 (Zone C: upper left corner)
|Canon 24mm L / f16 corner
|Zeiss ZF 25mm / f16 corner
|Canon 24mm L / f16 corner
|Zeiss ZF 25mm / f16 corner
0 points
1 point
Though the margin is very slight, at f16 there's little doubt in my mind that the Zeiss ZF 25mm is better across the frame and only at this aperture does it outperform the Canon L's corners.


text:
Bio-Chemist Formulated
Shead creates transformative, organic, essential-oil infused shea butter products free of preservatives or cruelty that can be trusted by families of all skin-tones.
"We're Not Your Average Shea Butter!"
Imagine living in a place where you leave home with hats, boots, and gloves, and come back wearing shorts, T-shirts, and sandals. Well, that's the reality of Michigan! Our co-founders Geren and Melissa, endured harsh winters and excruciating summers, finding it is extremely difficult to find a year-round product that gave their skin the protection it deserved. On top of that, there was just too much "junk" in their previous skincare products. Leaving their skin either dried out and reacting adversely. This is why Shead exists.
Started by bio-chemist Momma Coco, Shead has been perfected over 3 generations. Shead handcrafts non-whipped, organic & essential-oil infused shea butter dedicated to carter to you, the little ones and whole family. We take the junk out of skincare! Our products are free of preservatives, cruelty and committed to sustainable practices. We're not your average shea buttter! Join our team, become sheadkeeter and help us fight against dry-skin and over usage of plastics.
Questions & Concerns? Email us at firstname.lastname@example.com
Click the link below to view our entire organic collection!


text:
TPD's MO has traditionally been to arrest him a couple days later. I can't believe the city court can't find a way to get these cases over. I can't believe Ron Zack can't find a way off the case.
> Reply-To:
> From: "ROY WARDEN"
> To: "ROBERT GAFFNEY"
> Subject: FW: GAFFNEY RE TRO ORDER.doc
> Date: Fri, 25 Sep 2009 15:58:07 -0700
> From: ROY WARDEN [mailto:email@example.com]
> Sent: Friday, September 25, 2009 3:40 PM
> To: 'email@example.com'
> Subject: RE: GAFFNEY RE TRO ORDER.doc
> I just re-read my commentary to you.
> Please don't take it as a reflection on your services performed to date. Simply speaking; every time they have to provide me with an attorney for some alleged violation the story gets bigger. Now, I have three court appointed attorneys working on Roy Warden Cases. Maybe when they employ ½ the lawyers in town to provide for my defense their resources will be stretched too thin and they'll stop arresting and prosecuting me.
> Sort of a scorched earth war of attrition, a common enough strategy don't you think?
> From: ROY WARDEN [mailto:email@example.com]
> Sent: Friday, September 25, 2009 12:31 PM
> To: 'Robert Gaffney'
> Subject: RE: GAFFNEY RE TRO ORDER.doc
> Thanks Mr. Gaffney:
> Within the last two hours I re-violated the 1,000 feet order and burned two Mexican Flags in front of the Pima County Courthouse, the Brown Berets, 100 assorted protestors/counter protestors, 50 or more sheriff deputies and TPD officers, etc.
> If they arrest me, please make them get another lawyer, unless you REALLY, REALLY want to spend significant time litigating the constitutional issues.
> From: Robert Gaffney [REDACTED--BSK]
> Sent: Friday, September 25, 2009 12:15 PM
> To: email@example.com
> Subject: Re: GAFFNEY RE TRO ORDER.doc
> Attached, please find the court's orders re: not going within 1000 feet of 33 N. Stone or going to the Library, etc. If you need anything else, let me know.
> Bob Gaffney
> -----Original Message-----
> From: "ROY WARDEN"
> Sent 9/22/2009 5:25:20 PM
> To: "'Robert Gaffney'"
> Subject: RE: GAFFNEY RE TRO ORDER.doc
> Scan and email it. It can be an attached file. Thanks!!
> From: Robert Gaffney [REDACTED--BSK]
> Sent: Tuesday, September 22, 2009 5:23 PM
> To: firstname.lastname@example.com
> Subject: Re: GAFFNEY RE TRO ORDER.doc
> I am now able to send you the court order prohibiting you from going within 1000 feet of 33 N. Stone. Do you want me to fax it to you or scan and email. Let me know. If you want a fax, give me your fax number.
> Bob Gaffney
> -----Original Message-----
> From: "ROY WARDEN"
> Sent 9/16/2009 5:04:22 PM
> To: "'Robert Gaffney'"
> Subject: RE: GAFFNEY RE TRO ORDER.doc
> Thanks Robert. Unfortunately the City Court has a 1 week delay in getting the file. So, we'll just have to do the best we can…
> From: Robert Gaffney [REDACTED--BSK]
> Sent: Wednesday, September 16, 2009 3:46 PM
> To: firstname.lastname@example.com
> Subject: Re: GAFFNEY RE TRO ORDER.doc
> I am out of the State right now and won't return until next week. I'll get it to you as soon as possible. If you need it sooner, you can get copies from your file in Tucson City Court.
> -----Original Message-----
> From: "ROY WARDEN"
> Sent 9/16/2009 10:20:49 AM
> To: "ROBERT GAFFNEY"
> Subject: GAFFNEY RE TRO ORDER.doc
> []
> September 16, 2009
> Robert Gaffney
> Attorney at Law
> Re: Arizona v Warden
> Dear Mr. Gaffney:
> I am about to undertake a course of action which will impact our case(s) and your representation, I hope in a positive way.
> In spite of the various orders against me, over the past several months I've participated in and spoken at a series of political rallies associated with Smart Girl Politics, the Tucson Tea Party, Anti OmamaCare, etc., all without response from the Tucson Police Department.
> I am now organizing a Counter Protest rally for 9 am Friday September 25, 2009 in front of the Pima County Superior Courthouse, where various groups will gather in opposition to the Brown Berets, a militant, "Pro Raza" activist group promulgating, among other things, a racist, open border viewpoint.
> At this point I intend to speak out against Pima County Open Border Policy, the Tucson City and Pima County Superior Court judges who have protected such policy, and to Burn a Mexican Flag. Of course this activity will (1) piss off the local judges and (2) directly put me in violation of several Municipal Court orders prohibiting my political speech, which I contend, are beyond the jurisdiction of the Court to issue.
> Prior to the event I plan to move the federal court for a TRO enjoining the Tucson Police Department from interfering with my activity. Since I've never done one before I presume I will have significant research to do, etc.
> As an exhibit I need a copy of whatever paperwork you now have which proves there is currently an Order of the Court which prohibits me from coming within 1,000 feet of the corner of Pennington and Stone, or whatever it says, and the fact that I am now being prosecuted for being in violation of such order.
> Would you be so kind as to scan in whatever material you now have and email it to me? You shouldn't need any more than a page or two.
> Thank you for your help!
> Roy Warden
> CC Ronald Zack
A few remarks:
- No, I did not receive this from Bob Gaffney.
- Warden's actually relatively well-behaved. He's known for turning on his counsel (and sabotaging his own case) at the slightest provocation.
- An indigent with no visible means of support, Warden actually, briefly, had ACLU as counsel a few years ago, and has since then made use of services of the public defender's office.
- He's back on
NutzeroNetzero. Back in 2005, he was banned. I wonder if he slipped under the radar. I'm terribly busy but should send them an e-mail.
- Warden may have a legitimate civil liberties complaint--centered on what to my non-lawyerly eyes is a very interesting question--but the chances of him doing what needs to be done for relief are slim.
- Characters like this are very common in Southern Arizona politics and public life. Two of them--Joe Sweeney and Russ Dove--have run for Congress, Sweeney as a major party nominee. Lumping Dove in with those two is probably not fair, either, as he reputedly earns a living.
- The Left and the libertarians both have their share of nuts down here, too, but none whose antics are this protracted, or who are this loud.


text:
Hair extensions are becoming one of the most popular methods for a new hairstyle. In APOHAIR, bulk straight dark brown VD1 is considered to attract lots of customers these recent years.
Product description
It is the hair extensions in which the hair is tied in a bundle. Bulk hair is easy to apply, which helps you to save time for many other purposes.
Main features of hair products
Hair quality
- We use to produce is 100% Vietnamese women hair. It is long, black, and natural. That is really wonderful.
- No chemical or synthetic hair in any hair products. You do not need to worry about the quality of the hair extensions you like.
SEE MORE: Bulk straight dark brown hair VS2
Hair standards
Here, the standard we provide you is VD1. It is double drawn quality type 1.
Other hair standards for bulk hair are also attractive. You will certainly like our:
- bulk straight dark brown VS1
- bulk straight dark brown VS2
- bulk straight dark brown VD2.
You can choose natural straight, kinky straight of yaki straight for you bulk hair.
Colors and lengths
Dark brown color includes #2, #3, #4, #6 and #8. You can look at it clearly in the chart below:
The length of hair in our products varies from 6 inches to 32 inches. You can comfortably choose any of these lengths, depending on your own preference.
Apohair promises to provide you hair extensions with the best quality.
Testing bulk hair from APOHAIR:
Safe and guarantee
All the hair products provided by APO are 100% Vietnamese human hair. Hair remains in natural state as it is collected from Vietnamese women. Due to the fact that each bundle comes from one individuals, we cannot ensure hair textures and colors for all the hairstyles. However, we promise to try our best to supply customers with the best hair which helps to meets your demands.
Refund/ Exchange policyIn case you're unsatisfied with the hair products you purchased from APO, you can return them, meeting some criteria outlined below:
- Contact our customer service within 7 days of purchase to initiate a refund / exchange request.
- Hair is NOT installed, stained, cut or altered in any way
- Please note: If the item is removed from the package and used in any visible way, all return and exchange policies become invalid
- Hair must be in its original bundle and must not be tied at its top
- Hair must be in the original packaging
- Returned packages must include a copy of the original invoice
- Shipping and handling belong to the customer's responsibility
- Goods must be received at our company office before the refund can be issued
- Products must be returned at your expense. We recommend using a shipping service provider with a signature and / or insurance confirmation service to protect your package
- Please do not return unauthorized. We are not responsible for lost items, unauthorized returns or items sent to the incorrect address.
7 days products guarantee
You must contact us within 7 days of receiving your order.Based on the actual situation, we may ask you to send photos of your hair problem. If the problems can be resolved through maintenance regimen, then we may offer what product(s) may help to resolve your problem. If the problems cannot be resolved through maintenance, the hair must be sent back to us and received before we can take further action. As we want to determine if your purchase warrants replacement, the entire purchased amount of hair must be removed and mailed back to our office. Customers take responsibilities for all the costs of hair removal and mailing the products back. Also, we do not offer returns/exchanges for customized hair products.


text:
Tarantula paperweight-LG
Why, you say? Why not! Not everyone is an arachnophobe. Some may say they're cute. Some may say they're cuddly, okay...maybe not. Well for those who do enjoy spiders and the like, this is definitely for you. Measures 7 inches tall x 6 inches wide x 1.5 inches thick. Tarantula is approximately 4 inches long and 4 inches wide.
Made in China.


text:
Hi I'm very new to python and I'm still struggling with this problem. For the problem, I already created a function called reverse_complement, which computes the reverse complement of the input DNA sequence given.
Problem 3 (Virtual PCR):
You will write a program that performs "Virtual PCR" using pairs of PCR primers and a template sequence, much in the manner of UCSC's In-Silico PCR tool (http://genome.ucsc.edu/cgi-bin/hgPcr?command=start).
Your program (call it your_last_name_virtual_pcr.py) will load and assemble the pBR322 plasmid DNA sequence contained in hw_input\pBR322.txt - this will serve as your large target sequence. Your program will also load pairs of PCR primer sequences contained in hw_input\pBR322_PCR_products.txt. Note that each line consists of a forward primer sequence and a reverse primer sequence separated by a comma. You will use the unaltered forward primer sequence and the reverse-complemented reverse primer sequence to find the start and end positions of the predicted PCR product and then extract its sequence. Remember to import your reverse_complement function that you created in Problem 2 and use it to alter the reverse primer sequences.
Create an output file named hw_output\pBR322_PCR_products.txt and on each line write the forward primer, the reverse-complemented reverse primer and the predicted PCR product. Separate the fields with commas.
pBR322 primers.txt- I read it in as one long string
My pseudo code I've written is: 1. read the input file/import the function 2. create a for loop in order to obtain the complement sequence 3. Then I 'cleaned' the list by turning it into a list of lists so now it looks like this
4. Now I have to use my reverse_complement function to change the reverse sequences (I bolded them for clarity) into reverse_complement reverse sequences but Im having trouble doing this
fwd_and_rsvcomp_rsv_primers = []
for pair in cleaned_primer_list:
if pair[0]:
t = pair[0]
s = pair[1]
my output values on python shell gave me this (first string-foward sequence in each of the lists):
Next I have to use the forward and reverse complemented reverse sequences and use to find the start and end positions of the predicted PCR product and then extract its sequence. But Im stuck at the step where I have to use the reverse complement function though. I have no idea how to solve the next step. Can anyone help?


text:
And another one bites the dust: Charles Freeman out
Just breaking…
I wrote five days ago about the gathering firestorm over Saudi/China water carrier Charles Freeman's crappy nomination to serve as chairman of the group that prepares the U.S. intelligence community's most sensitive assessments.
Well, he's gone.
Director of National Intelligence Dennis C. Blair announced today that Ambassador Charles W. Freeman Jr. has requested that his selection to be Chairman of the National Intelligence Council not proceed. Director Blair accepted Ambassador Freeman's decision with regret.
Way to go again, Obama vetters!
More from The Hill:
harles Freeman, Director of National Intelligence Dennis Blair's choice to head the National Intelligence Council, has withdrawn from consideration for the post in the face of strong opposition from Senate Republicans.
Freeman is the latest in a string of Obama administration appointees and nominees to withdraw in the past few months.
Senate Select Committee on Intelligence chairwoman Dianne Feinstein (D-Calif.) told The Hill that Freeman has withdrawn his nomination and that Blair agreed to accept the decision.
Freeman had been scheduled to appear before the Senate intelligence panel on Thursday to answer senators questions.
Earlier on Tuesday Feinstein told The HIll she was keeping an open mind on Freeman's appointment.
"I've talked to director Blair about it. Director Blair feels this is not a policy job, that he's well qualified for what he wants him to do," Feinstein said. "I feel presidents should have their choice if possible of appointments. I've read Mr. Freeman characterized in a number of different of ways. We'd like an opportunity to talk with him and get our own fix on these views. How strongly their held, whether in fact there is bias."
Feinstein said she did not have any concerns over Freeman as of lunchtime Tuesday but that she might change her mind depending on his answers before the intelligence panel.
Republicans, however, were staunchly opposed to Freeman's nomination.
Marie Harf: Hey, Trump couldn't be defeating ISIS without Obama doing so little about it
December 28, 2017 05:07 PM by Doug Powers
Confirmed: Obama & his flacks need some self-awareness for Christmas
December 24, 2017 08:37 AM by Doug Powers
Anybody surprised? Susan Rice slams Trump's 'America First' approach
December 21, 2017 08:16 PM by Doug Powers
CNN sounds alarm about 26-year-olds falling off parents' insurance, blames Trump
December 13, 2017 07:30 PM by Doug Powers
How can MSM prove they're making 'honest mistakes' about Trump? Simple
December 10, 2017 09:13 AM by Doug Powers
Categories: Barack Obama, Donald Trump, Media, Media Bias


text:
Hair flicks and stings as the wind gives gentle reminders not to push the luck, like a caring aunt. Wobble but no fall, the heart doesn't stop, it's a hazy day in a bramble sea whilst the grass waves on an appreciative marathon crowd. To tingle is effortless, to admire is hopeless, to aspire is pointless and The Future consists of one second. I've been twunted and menaced about the head six times today and there is blood forming a smile on the corners of my lips. We eat blackberries, and tunnel to Paris, popping up briefly in a bistro and causing a scene. Jumping from walls using carrier bags as parachutes, digging heels into the melting tarmac, skating under a cold day when the football stings the lips and we throw javelins at the church, because it's easy. I can hold fire and it doesn't burn my palms, it just goes up like a dove and it is saluted away.
Later, I lick sweat from the walls as my ears ring and everyone's eyes are glowing like laser beams. Teeth are green or blue depending on personal hygiene. Going low, amid the broken bottles. Reaching high to scratch initials into the ceiling. A girl did the same, winked and unzipped me, just in time for the song to finish.
It is easier to run at night. Perspective changes – you feel as though you are running faster and burning less energy. I regularly run, away from Jeep's filled with spiders, from balletic old men, from the smell of Old Spice and ghosts. I see them in the bowling alley, leaning and smoking against the pool table in the lobby, in front of a gold room where I had my first drink surrounded by frowning Dads.
Picking away at bubble gum stuck to a bench that doesn't exist. She wore the same bellbottoms for seven years, stiff with mud at the bottom. She could still see where he spat on her knee, just one of thousands of gestures designed to denigrate her and for which she loved him more. Even now, she sits and hovers her palm over the spot, terrified to remove what isn't there.
I remember it is seven years ago to the day since I kicked the shit out of a television on a piece of waste land near the shell of a supermarket. To celebrate, I drive a shopping trolley hard into a parked car and sprint away as the alarm sounds and dogs bark. It leaves a perfect silver grid on the blue driver's door. Kicking stones into imaginary goals, lifting up sewer drains and dragging shit out with an iron bar to smear on doors. I find an abandoned garage and sleep inside. When I wake up, there's a man asleep next to me, spooning me, with arms covered in dark red craters.
I suppose throwing the child's pram – with child – into the duck pond was the final straw. A man, so incandescent as to be illogical, threw bread at me before the group pounded me deep into the soil.
The man who ran the antique shop shouted at me for wearing a coat and scarf. Apparently, it wasn't cold enough to wear a coat and scarf. He shivered in Bermuda shorts, goose pimpled arms slithering out of a Hawaiian shirt. He returned his glasses to his face with the disappointment of someone retrieving their hated and long lost sibling at the airport.
The cigar box, made of a light wood – perhaps balsa, still had my name. It had been water damaged and my felt tip drawings were smeared into the picture of a disorganised artist's palette. Inside, the dried leaves were too fragile to touch, but the lighter still carried a puddle of gas. The note I had written to myself was missing.
I took out the empty miniature whiskey bottle, still with a thin line of tape stretched across the lid. I unscrewed it and had a deep sniff of old air. The man asked for twenty, I gave him double, and left as the other half of a book-end I'd been trying to find.


text:
For the convenience of users, this part of SINA has been divided into the seven items listed below. The first five items are briefly described, and each of the seven items can be accessed by clicking on its title. Once the item is viewed the user can peruse what is offered or simply return to this menu.
(1) Brief history of Ensifera holdings in FSCA
A two-page account of TJW's curatorship of the FSCA's Ensifera with the last half describing the development of the Walker Tape Library (WTL) and its systems of cataloguing tape recorded "cuts" of songs of known and unknown species.
(2) Finding specimens of crickets and katydids in FSCA
An introduction to the physical layout of the pinned and alcohol Ensifera holdings in the Doyle Conner Building, followed by details of how to use two online catalogs to find specimens of species of interest. (This includes how to find tape-recorded specimens and the MLNS catalog numbers of their recorded songs.)
(3) Tables from the GrylTett database
The origin, content, and history of the GrylTett database are summarized here. Of greatest importance to those interested in ensiferan songs is its tblRecordedSongs, which has links to ca. 6460 cuts from the Walker Tape Library that were digitized and archived by MLNS.
(4) Accessing 6460 cricket and katydid songs from SINA's FSCA section
Illustrated steps to finding, exploring, and downloading ensiferan songs from Cornell's Macaulay Library of Natural Sounds.
(5) Relevant websites and their interrelations
A quick review of these sites and their interrelations: SINA, OSFO, MLNS, WTL, and IR@UF.
(6) Suggestions for those in need of help regarding the FSCA section of SINA
(7) Features of the rest of SINA that may benefit those primarily interested in the FSCA section
Return to FSCA Ensifera Topics


text:
Come on in!
68, High street, Lindfield, West Sussex, RH16 2HL
01444, 482393
Foxy Feet Shoe Boutique is a ladies shoe, clothing and accessories shop situated on the beautiful High Street in Lindfield village, near Haywards Heath, West Sussex selling on trend shoes, ankle boots, knee high boots, trainers, sandals, court shoes and now a fabulous range of clothing. We offer a wide range of brands and styles, including Moda in Pelle, Tamaris, Lunar, Alpe, Woden, Caprice, Fitflop, S Oliver, Jana, Toni Pons, Lilly & Me, Sugarhill Brighton, Numph, Studio and others. We are always introducing new brands each season. We also stock a range of handbags, hosiery and shoe care products including Clean Heels and Euroleathers.
Our brands are all hand-picked for their quality and affordability. New stock comes in regularly so do pop in, have a browse and chat to our friendly staff who are always happy to lend a helping hand in your search for the perfect shoe or top! Xx
How to find us
Contact us
Returns Policy


text:
Cousin Camp continues
with Day 3 bringing
"moving indoors"
kinds of activities.
(After yesterday's Zoo Trip,
I needed to spend some time in the
air conditioning...) ;0)
We began our day with a trip to...
This pic is of us looking into the mirror above us
while we wait in line to buy tickets.
...the movies.
Many theaters out there have great
CHEAP summer movie programs
to participate in.
We chose a Regal Cinema Theater
and went to see...
...Dolphin Tale.
We had seen this movie before,
but our cousin hadn't,
and I am always up for a heart-warming story...
In fact,
I really surprised myself and teared up
a couple of times during the movie.
(Trust me-
I hardly EVER cry in movies...)
You can still see Winter the Dolphin
(star of the movie)
by clicking HERE.
After the movie,
we ran a few errands and then came home
for some crafty fun...
Crafty fun, you say?
I have several craft kits stowed away
that the kiddos and I have received over the years,
for afternoons like this one.
Little Wild Man got to try out his...
while the girls worked on
something else more "girlie."
He drew several pictures
and then promptly tested them out...
...in our bathroom.
While Little Wild Man was drawing away...
...the girls created bracelets and rings using this
Their creations have to dry for 24 hours,
so we will have to wait to see the final results...
all the kiddos worked together to make...
...a Suncatchers Bouquet.
Don't you just love Cousin K-K's face in this picture?
to be 11 again...
The results of the Suncaters
is rather pretty,
don't ya think?
So what is up next for this group of...
...Crazy Cousins?
I do believe we will be venturing back
into the Great Outdoors...


text:
Recommended Stories
Large Queens Multifamily Property Trades
The 32,184-square-foot multifamily property closed at $4.7 million, or approximately $149 per square foot.
Imperial Dade Signs Nearly 29,000 SF Lease in North Bergen
The new space will house Imperial Dade's executive team as well as office operations, including finance, human resources and customer service. The firm's current Jersey City facility will serve as its largest distribution center.
ABS Altman Warwick Closes $13M Loan for Plaza District Property
ABS Altman Warwick, a New York City-based capital market advisory firm and division of ABS Partners Real Estate, has closed a $13.5 million loan for an office building located at 425-427 Madison Ave. in the Plaza District.
Resource Center
White Paper
Sponsored by RealPage
The Four Success Pillars of Commercial Real Estate
These four pillars of success will help you leverage the strength of the CRE market in 2020; while navigating unexpected industry challenges to thrive and separate yourself from the competition.
GlobeSt. NET LEASE 2020Event
Get More Information
GlobeSt. NET LEASE 2020Event
Get More Information
GlobeSt. Apartments 2020Event
Get More Information
Don't miss crucial news and insights you need to make informed commercial real estate decisions. Join GlobeSt.com now!
- Free unlimited access to GlobeSt.com's trusted and independent team of experts who provide commercial real estate owners, investors, developers, brokers and finance professionals with comprehensive coverage, analysis and best practices necessary to innovate and build business.
- Exclusive discounts on ALM and GlobeSt events.
- Access to other award-winning ALM websites including ThinkAdvisor.com and Law.com.
Copyright © 2020 ALM Media Properties, LLC. All Rights Reserved.


text:
HIV stands for human immunodeficiency virus. The virus attacks the immune system, and weakens your ability to fight infections and disease.
HIV is a virus most commonly caught by having sex without a condom.
It can also be passed on by sharing infected needles and other injecting equipment, and from an HIV-positive mother to her child during pregnancy, birth and breastfeeding.
There is no cure for HIV, but there are treatments to enable most people with the virus to live a long and healthy life.
AIDS is the final stage of HIV infection, when your body can no longer fight life-threatening infections. With early diagnosis and effective treatment, most people with HIV will not go on to develop AIDS.
How is HIV spread?
HIV is found in the body fluids of an infected person, which includes semen, vaginal and anal fluids, blood and breast milk. It is a fragile virus and does not live very long outside the body.
HIV cannot be transmitted through sweat or urine.
The most common way of getting HIV in the UK is by anal or vaginal sex without a condom.
Other ways of getting HIV include:
- using a contaminated needle, syringe or other injecting equipment
- transmission from mother to baby during pregnancy, birth or breastfeeding
- through oral sex or sharing sex toys (although the risk is significantly lower than for anal and vaginal sex)
Read more about how is HIV spread
Causes of HIV
In the UK, most cases of HIV are caused by having sex without a condom with a person who has HIV.
A person with HIV can pass the virus to others whether or not they have any symptoms. People with HIV are more infectious in the weeks following infection.
HIV treatment significantly reduces the risk of someone with HIV passing it on.
According to the Health Protection Agency, 95% of people diagnosed with HIV in the UK in 2011 acquired HIV through sexual contact.
The main routes of transmission are unprotected vaginal and anal sex. It is also possible to catch HIV through unprotected oral sex, but the risk is much lower.
The risk of HIV transmission through oral sex will be higher if the person giving oral sex has mouth ulcers, sores or bleeding gums and/or if the person receiving oral sex has been recently infected with HIV (and has a lot of the virus in their body) or another sexually transmitted infection.
The type of sex also makes a difference to the level of risk:
- performing oral sex on a man with HIV carries some risk, particularly if he ejaculates (comes) in your mouth
- it is possible to catch HIV by performing oral sex on a woman with HIV, particularly if she is having a period, although this is considered to be extremely low risk
- receiving oral sex from someone who has HIV is also extremely low risk as HIV is not transmitted through saliva
Other ways of getting HIV include:
- healthcare workers accidentally pricking themselves with an infected needle (this risk is extremely low)
- blood transfusion (now very rare in the UK, but still a problem in developing countries)
How common is HIV?
At the end of 2012, there were an estimated 98,400 people in the UK living with HIV. The majority were infected through sex (41,000 gay and bisexual men and 53,000 heterosexuals).
More than 1 in 5 people with HIV (over 20,000) do not know they are infected.
Around 1 in every 650 people in the UK has HIV but the two groups with highest rates of HIV are gay and bisexual men and African men and women, where the rates are approximately 1 in 20 and 1 in 25 respectively.
The World Health Organization estimates that around 34 million people in the world are living with HIV.
The virus is particularly widespread in sub-Saharan African countries, such as South Africa, Zimbabwe and Mozambique.
Symptoms of HIV
Most people who are infected with HIV experience a short, flu-like illness that occurs two to six weeks after infection. After this, HIV often causes no symptoms for several years.
The flu-like illness that often occurs a few weeks after HIV infection is also known as seroconversion illness. It's estimated that up to 80% of people who are infected with HIV experience this illness.
The most common symptoms are:
- fever (raised temperature)
- sore throat
- body rash
Other symptoms can include:
- tiredness
- joint pain
- muscle pain
- swollen glands (nodes)
Read more information about Getting tested
Living with HIV
Although there is no cure for HIV, treatmentsare now very effective, enabling people with HIV to live long and healthy lives.
Medication, known as antiretrovirals, works by slowing down the damage the virus does to the immune system. These medicines come in the form of tablets, which need to be taken every day.
You will be encouraged to take regular exercise, eat a healthy diet, stop smoking and have yearly flu jabs and five-yearly pneumococcal vaccinations to minimise the risk of getting serious illnesses.
Without treatment, a person with HIV's immune system will become seriously damaged and they will develop life-threatening illnesses such as cancer. This is known as late-stage HIV infection or AIDS.
Read more about Living with HIV
HIV and AIDS - Treatment
There is no cure for HIV, but there are treatments to enable most people with the virus to live a long and healthy life.
Emergency HIV Drugs
Antiretroviral Drugs
Missing a dose
Side effects
Preventing HIV
Anyone who has sex without a condom or shares needles is at risk of HIV infection.
The best way to prevent HIV is to use a condom for sex and to never share needles or other injecting equipment (including syringes, spoons and swabs).
Read more information about: Preventing HIV
How We Can Help
We offer a completely confidential service and our Pharmacists are available to speak with you either by phone or email. Call us today on 0844 247 0 365 or email email@example.com and see how by purchasing our Dispensing Card can save you money and help make life a little easier.
Medicines for HIV and AIDS
Supplements for HIV and AIDS


text:
Published on Jan 13th, 2017
The Consumer Electronics Show in Las Vegas wrapped up this week. From robots to Razer, we break down what everyone was buzzing about on social media.
A laundry-folding Robot? Sign us up! The bot called Laundriod , which can sort and fold clothes, was one of the most talked about products at CES, especially among women. "Robot" was a top keyword for both women and men, while "Razer," "laptop" and "smartphones" were most popular for men. Interestingly, men had 418 keywords compared to 201 from women.
The gaming company Razer was the most talked about brand at the show on social. Gamers went wild for the prototype of their gaming console , dubbed "Project Valerie," which is the first portable laptop with three built-in monitors. Razer also debuted "Project Ariana," in which depth-sensing cameras and projectors expand your TV on the wall for a virtual reality gaming experience. "Virtual Reality" and "Video Games" were also trending topics.
While the most comments on social came from the 25 to 34 age bracket, it was a product from the kids' toy company Lego that was most talked about among 35 to 44 year olds. Turns out both adults and kids enjoy playing with robots. Lego Boost allows you to build your own robots using an app where you drag and drop actions to control the bot.
Another buzz-worthy idea was the integration of Amazon Alexa into just about everything. Whether it's appliances, lighting, home security systems or phones, Alexa voice control can command most of your favorite gadgets – even your car. With a focus on autonomous driving and voice-assisted features, connected cars were another a big trend . Self-driving cars could be taking over the roads in the very near future.
It seems that more and more devices are being controlled by smartphones these days, so it's surprising that the top device used for posting about CES was the desktop, with iPhone and Android tying for second place. The top hashtags were #ces2017, #3Dprinting, #TeamEricsson, a community dedicated to the telecom company's content, and #zenfoneAR, which is the first augmented and virtual reality smartphone.
CES always gives us a fun peek into the future of technology. In looking at what was trending on social, it's clear that users are excited to see things that were once fanciful (Hello, robots!) are now becoming a reality.
If you want to compare what trended on social at CES in 2016, take a look at this post.


text: [vc_row][vc_column width=»1/1″][vc_single_image image=»4330″ style=»vc_box_rounded» border_color=»grey» img_link_target=»_self» img_size=»full»][/vc_column][/vc_row][vc_row][vc_column width=»1/1″][vc_column_text] Otros nombres: [/vc_column_text][/vc_column][/vc_row][vc_row][vc_column width=»1/1″][vc_separator color=»grey»][/vc_column][/vc_row][vc_row][vc_column width=»1/1″][vc_column_text]ORIGIN : Southeastern Europe. PATRONAGE : Romania and Serbia. DATE OF PUBLICATION OF THE OFFICIAL VALID STANDARD : 26.03.2009. UTILIZATION : Guardian for flocks and an excellent watchdog. FCI-CLASSIFICATION : Group 2 Pinscher & Schnauzer, Molossoids breeds, Swiss Mountain and Cattle dogs. Section 2.2 Mountain type Molossoids. Without working trial. BRIEF HISTORICAL SUMMARY : It is a natural breed with its origin in the Carpathian Mountains (Romania and Serbia) and the South of Danube (some regions of Bulgaria). Special attention for the development of the breed arose in the regions of northeastern Romania, the county of Bucovina as well as in the South of the Danube (Serbia) : the well-known transhumance areas of the shepherds since immemorial times. Selection and improvement have lead to the actual type. The breed is successfully used both for defending the flocks and herds and as watchdogs for households in the mentioned regions. GENERAL APPEARANCE : Large sized dog; commanding, haughty and proud. The breed has an obvious sexual dimorphism. IMPORTANT PROPORTIONS : The length of the body is slightly superior to the height at the withers. The length of the skull is equal to the length of the muzzle. FCI-St. N° 357 / 19.05.2009 3 BEHAVIOUR/CHARACTER : Balanced, calm and loyal, he likes children. It is a very good guardian for flocks, courageous and a real fighter against the possible animals of prey (bear, wolf, and lynx). It has a strong bark. When strangers or animals approach, its barking is very strong, with a low tonality. During the night, it patrols around the household or the flock/herd. HEAD : Massive but not heavy, slightly higher than the topline. CRANIAL REGION : Skull : Moderately wide, slightly domed. The upper profile of the skull and muzzle are slightly divergent. Viewed from the front, the skull is slightly domed, seen from the side it is almost flat. Skull width: males 16-18 cm, females 15-17 cm, zygomatic arches are moderately developed. Occipital protuberance is slightly evident. Stop : Slightly pronounced. FACIAL REGION : Nose : Large, well developed, black. Muzzle : Blunt, of the same length as the skull; well developed, narrowing progressively towards the nose but never pointed; strong mandible. Lips : Thick and tight, strong pigmentation. Jaws/Teeth : Strong jaws; complete dentition, strong, healthy and white teeth, well set; scissor bite. Pincer bite is tolerated. Cheeks : Not prominent. Eyes : Small related to the head; almond-shaped and obliquely, brown or slightly light but never yellow. Eyelids well pigmented. Ears : Relatively high set, "V" shaped with slightly rounded tip, pendent and carried close to cheeks. Cropping is prohibited. NECK : Medium length, large and strong, without dewlap. BODY : Good stamina. Topline : Horizontal. Withers : Slightly evident. Back : Strong and muscular. Loin : Muscular and strong. FCI-St. N° 357 / 19.05.2009 4 Croup : Muscular and moderately inclined towards base of tail. Chest : Broad and deep, descending to elbows, well sprung ribs. Underline : Slightly ascendant. TAIL : High set-on. At rest, it is pendent; reaching to or lower than the hock; when the dog is alert or in action the tail is raised up to the level of the back or slightly above it, with slight upward curve, but never curled over the back. Docking is prohibited. LIMBS : FOREQUARTERS : General appearance : Upright, seen from the front or the side. Shoulders : Long, oblique, well muscled and firmly attached to the body. Scapular-humeral angle approximately 100-110°. Upper Arm : Moderately long, muscular. Elbow : Close to the body, free movement. Forearm : Strong, not too long. Carpus (wrist) : Strong. Pastern : Short, slightly slanting. Forefeet : Oval, compact and massive, toes tight and arched, black or ashen nails. HINDQUARTERS : General appearance : Muscular and strong, normal in stance. Upper Thigh : Medium long, wide, very muscular. Stifle : Femoral-tibia angle is aprox. 110°. Lower thigh : Moderately long, muscular. Hock : Wide, viewed from the side, moderate angulation. Seen from behind, parallel to median plane of body. Metatarsus (Rear pastern) : Strong and upright. The presence of dewclaws should not be penalized. Hind feet : Oval, compact and strong, with black or ashen nails. GAIT/MOVEMENT : Harmonious, elastic, well coordinated, giving the impression of effortless power. Preferred gait is the trot. Crossover will be penalized. FCI-St. N° 357 / 19.05.2009 5 SKIN : Thick, close fitting, dark-ashen pigmentation. COAT HAIR : Head and the front part of the legs are covered with short hair. On the body, hair is abundant, long (6-9 cm), flat, straight and rough. Undercoat is shorter, very dense and supple, and of a lighter colour. At the neck region, hair is much longer forming a mane; on the backside of the forequarters, the hair forms fringes; on the backside of hindquarters, the hair is longer and forms culottes. The tail is bushy. COLOUR : Classical colour : Main colour of coat is a clear white or white-beige with distinct patches of grey, black or black with red-fawn reflections. Black or grey ticks can appear on the legs. Brindle aspect of patches to be rejected. Solid colours : Solid coloured subjects (without patches) are accepted but not encouraged: white, white-beige, ashen-grey or black. SIZE AND WEIGHT : Height at withers : Males : 68-78 cm, ideal 71-75 cm Females : 64-72 cm, ideal 66-68 cm Tolerance : – 4 cm Weight : In proportion to height FAULTS : Any departure from the foregoing points should be considered a fault and the seriousness with which the fault should be regarded should be in exact proportion to its degree and its effect on the health and welfare of the dog. · Lack of substance or too heavy. · Not sufficient sexual character. · Absence of 1 tooth other than P1. FCI-St. N° 357 / 19.05.2009 6 · Cropped ears. · Docked tail. · Overweight or weak subject. · Faulty hair or short hair (under 6 cm). · Hair too long (over 9 cm). · The absence of mane, or fringes on the legs. · Tail curled or carried in a ring. · Flabby toes, toeing in or out. · Elbows turning out. · Heavy gait. SERIOUS FAULTS : · Untypical expression. · Round, protruding eyes. · Erect ears. · Top line sagging or dipping. · Hair too short. · Curly coat or bad texture. · Yellow eyes. · Different colour of eyes (heterochromatic). · Cow hocked. ELIMINATING FAULTS : · Aggressive or overly shy. · Any dog clearly showing physical or behavioural abnormalities shall be disqualified. · Not typical subject. · Overshot or undershot bite. · Absence of incisors or canines. · Albinism. · Naturally absent or atrophic tail. · Height under 64 cm or over 82 cm (for males). · Height under 60 cm or over 78 cm (for females). FCI-St. N° 357 / 19.05.2009 7 N.B.: · Male animals should have two apparently normal testicles fully descended into the scrotum. · Only functionally and clinically healthy dogs, with breed typical conformation should be used for breeding.[/vc_column_text][/vc_column][/vc_row][vc_row][vc_column width=»1/1″][vc_separator color=»grey»][/vc_column][/vc_row]


text:
Beautiful day sailing in the harbour with Peter, Caroline and Graciela.
10 knot southerly winds, clear skies, calm sea.
Used Genoa 1 and Mainsail and sailed to Matiu/Somes Island. Put anchor down and had a swim and afternoon tea. Cleaned the outside of the hull with cloth and noticed the flange had fallen off and water had been getting into the stern locker. Peter and I bailed out the locker and did a temporary repair to the flange.
On return there was no wind at all so had to motor home. After a while suddenly noticed cabin was filling with smoke and fumes. Checked the engine but no visible problems. Later inspection by Travis on Monday revealed a leaking exhaust pipe. Will be repaired this week.
Cruising >


text:
A new, superior standard in advanced surfacing materials: DuPont™ Corian® introduces the DeepColour™ Technology*
There is an exciting new option available for industrial companies, architects, designers and consumers looking for solid surface solutions in dark colours offering high performance, elegance, reliability and hygiene.
Within its long-term growth initiative "Endless Evolution", DuPont is once again setting a new, superior standard in advanced surfacing materials for interior design and architecture: the research and development laboratories of DuPont have developed an innovative manufacturing solution called DeepColour™ Technology* (a patent pending invention, www.deepcolour.corian.com) enabling the creation of dark solid surfaces which offer deeper, more intense and durable colour, improved wear performance and easier thermoforming, seaming and finishing.
The DeepColour™ Technology has been used by DuPont to produce four black tones:
- DuPont™ Corian® Deep Nocturne, a classic, solid, super-versatile jet black;
- DuPont™ Corian® Deep Anthracite, a lustrous black immersed with minute flecks of silver.
- DuPont™ Corian® Deep Black Quartz, an infinite black landscape offset by a vivid array of ivory specks;
- DuPont™ Corian® Deep Night Sky, a midnight black with a galaxy of translucent particles.
The four colours of DuPont™ Corian® made with DeepColour™ Technology will be commercially available in Europe, Middle East and Africa as of 1st February 2014.
For further informations click here.
DuPont™, Corian®, the Endless Evolution logo and DeepColour™ are registered trademarks or trademarks or copyrighted material of E. I. du Pont de Nemours and Company or its affiliates. Other trademarks and registered trademarks are property of their respective owners. *Patent Pending


text:
Get a lot of money and get rid of ads in an amazing Word Across game by installing our unique VIP Mod.
Word Across is an addictive puzzle game on android where you have to guess words from a crossword puzzle. Guess words by composing them from letters located on your screen and travel to colorful places from the scenery. In total, this game features over 2000 funny words that you can solve using your smartness and ingenuity. Increase your vocabulary and pass exciting levels. Unlock more than 100 amazing landscapes such as flowers, lakes, mountains, forests, ocean, clouds and others.
Use our new VIP Mod to get the most out of Word Across.
Download Word Across : VIP Mod


text:
Principal Investigator: Dr Nicole Washington
HelixTags: 40436, genomic prediction, GWAS, health, Polygenic, risk-score, wellness
Helix is a personal genomics software platform, formed by Illumina and two venture capital firms in 2015, with the mission to empower every person to improve their life through DNA. Helix sequences our users' Exome+, a combination of clinical-grade exome sequencing plus sequences that overlap SNPs traditionally found in genotyping arrays. Helix enables every person to access interpretations from their germline genomes through third party partners such as National Geographic, Mayo Clinic, Mount Sinai Sema4, with products that cover a broad spectrum of traits and diseases including ancestry, nutrition and diet, familial hypercholesterolemia, carrier screening, among others.
Genome-wide association study (GWAS) is a standard method for identifying genetic risk factors for common traits and complex disease that hastens hypothesis generation and exploration of their biological underpinnings. However, individual variant-phenotype associations have limited personal utility. Genetic risk scores, a single predictive score for the overall genetic contribution to a trait that can be derived from GWAS analyses, are a powerful tool to stratify disease-risk populations for common traits and disease, including height, sleep, coronary-artery disease, and obesity. However, the catalog of these scores is limited and must be expanded and refined to maximize their utility.
Helix's research goals include improving analytical methods and interpretability of the genome, furthering the overall scientific knowledge and genetic mechanisms of health and disease while growing the global knowledge of genetic-phenotype associations. Therefore, we aim to (1) develop and validate risk scores for common health and wellness-related traits and (2) develop novel genomic prediction algorithms using advanced machine learning techniques for linking genotype to phenotype.
The UK Biobank (UKB) data is ideal for developing genetic risk scores and other prediction algorithms because of the large sample size and breadth of phenotypic data. Validation of association analysis from an independent cohort will strengthen findings and provide confidence in predictive models. With our population health study collaborations, such as with the Integrated Health Institute (IHI) and Renown Health, we will be able to perform validation studies in an effort to improve health outcomes. Together, the UK Biobank and Helix datasets will provide a rich analytical basis with which to discover and validate predictive models of health and wellness traits. We anticipate that this research effort will, in turn, enable more products to return actionable and individualized results, which we hope will increase the popularity, diversity, and impact of personal genomics.