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Chasing Shadows Moonlight Mystery
I mentioned yesterday there were no expectations heading into last night's game, and maybe that's why I came away with good vibrations from the loss in Boston. Edmonton won the 5-on-5 high danger scoring chances 7-4 (Natural Stat Trick), Cam Talbot stopped 26 of 27 at 5-on-5, McDavid hammered the sliver of a chance given for a goal, plus the Oilers had some great looks. That last item is the problem, ladies and men. Edmonton needs goals like Mars needs women. We're on to Manhattan.
The Athletic Edmonton is going to bring it all season long. Proud to be part of a lineup that is ready to cover the coming year. Outstanding coverage from a large group, including Daniel Nugent-Bowman and Jonathan Willis, Lowetide, Minnia Feng and Pat McLean. If you haven't subscribed yet, now's your chance. Special offer is here, less than $3 a month!
- New Lowetide: Panic storm on the horizon as Oilers remain a one-man show
- New Lowetide: Joel Persson's early season performance in the SHL.
- Lowetide: Practice lines in Boston, anger in Edmonton and Kailer Yamamoto remains on the No. 2 line.
- Jonathan Willis: At 34, is Kyle Brodziak just too old to help the Oilers?
- Jonathan Willis: Why Todd McLellan's name keeps showing up on those 'first coach fired in 2018-19' lists
- James Mirtle: Sizing up the NHL 2018-19 by age, height and age (Oilers content)
- Black Dog: Edmonton's future is bright, but there are all kinds of questions in the present.
- Lowetide: Evan Bouchard survives first game.
- Lowetide: Ryan McLeod takes demotion in stride, while a Condo of Condors impress on opening weekend.
- Jonathan Willis: On AHL opening night, Caleb Jones and friends make it clear they want NHL jobs.
- Lowetide: Orange, white and blue October: In 1979, the Oilers rocked the NHL.
- Daniel Nugent-Bowman: After the death of his father, Sweden trip holds special significance for Adam Larsson, and one of his opponents.
- Scott Wheeler: How the eye test fails to properly evaluate Evan Bouchard.
- Daniel Nugent-Bowman: Why the Nuge-McDavid-Rattie line has been so successful.
- Lowetide: The 2018-19 Oilers are in a period of transition.
- Nurse-Benning were 5-4 Corsi for 5-on-5 in 9:39, 1-0 goals, 4-1 scoring chances. Nurse was also 2-1 in 3:10 with Evan Bouchard and 4-3 in 2:25 with Adam Larsson, as Benning was the incredible shrinking man in terms of ice time at 5-on-5. Pairing was 4-3 Corsi in 3:46 against Bergeron's line (Marchand, Pastrnak). Matt Benning can't go fishing like he did against Pastrnak, that kind of thing is going to get him a night in the pressbox. Seriously.
- Klefbom-Larsson went 10-17 in 15:19, 0-1 goals and 4-10 shots. Larsson went 4-3 in 2:25 with Nurse, 5-4 in 4:04 with Kris Russell. Klefbom's best moment was intercepting a pass from the corner to the slot that was a sure goal. Larsson played the Nordstrom goal strangely, thought there might be an interference penalty but it played out. Klefbom was 4-7 in 5:39 against the Bergeron trio, Larsson was 5-10 in 7:10 against the big unit. I'm not sure if that was luck, happenstance, or McLellan just telling Larsson to jump on whenever that group entered the game, but it's an interesting wrinkle to answer.
- Russell-Bouchard finished 4-8 in 8:04 together, 0-2 in high danger. Bouchard has a giant brain, it's wonder he can carry that thing around all day. Honestly, he's impressive. Great passing, improves positioning shift by shift. Very nice. I don't think he plays past nine games but he's the best rookie on the team. Went 0-2 in 57 seconds against Bergeron, another wrinkle in head to head matchups. Is someone matching the defense to forwards? Bouchard needed to shoot the puck at the end of the second period on the power play with just seconds left, instead he sent an errant pass and that's all she wrote. I love his decision making though, he seems to know all available options as the puck arrives.
- Cam Talbot stopped 26 of 27, .963, at 5-on-5.
- NaturalStatTrick and NHL.com.
- Lucic-Draisaitl-Yamamoto were 6-9 (Lucic) and 6-6 (Yamamoto) all three on the ice for the GA. Draisaitl and Lucic both had one high danger chance, for me Leon turned it on from the second period on and played closer to expectations. I'll tell you there's some concern in this corner of the Al Gore over Yamamoto, he doesn't get to the puck much and that's his game. Quick, tight passes, give and go. Not seeing it much. Line went 4-2 in 2:22 against Chara-McAvoy. 1-0 high danger. I would like to see Rieder on RW Saturday.
- Nuge-McDavid-Rattie got the goal, nifty little pass from Rattie and the rest was 97. Were 11-12 in 14:18, 1-0GF, 1-1 high danger. Went 11-12 against Chara, that pairing marked McDavid 13:43, so all but three minutes. That was the matchup Boston pursued. McDavid made Chara look foolish a few times but the Bruins won the game. I wonder if we see a similar matchup back in Edmonton.
- Rieder-Khaira-Kassian went 3-4 in 7:10, Khaira missed quite a bit of time serving a fighting major. Rieder got some time with Draisaitl (good chance with 29) and McDavid at different points, also got a clean breakaway. 0-1 high danger. Khaira took a penalty after getting hammered earlier, you could call it selfish but for me it was barely a penalty and could easily have been a non-call.
- Caggiula-Strome-Puljujarvi were 4-10 in 8:28, 2-2 in high dangers. Caggiula did a lot to get noticed, he hit a lot of people and made some noise, including a high danger chance. There's a 100 percent chance the organization liked Caggiula's game over Pulju's. Strome was quiet offensively, Puljujarvi took another penalty that led to a goal. I don't think the coaching staff sees JP as a dynamic player. If I'm Carolina, I'd make an offer for the big Finn this morning. You never know.
- High Danger Chances: Rattie (2), Lucic (2), McDavid (1), Caggiula (1), Yamamoto (1), Draisaitl (1), Nuge (1).
- Oilers in October 2015: 0-2-0, goal differential -4
- Oilers in October 2016: 2-0-0, goal differential +5
- Oilers in October 2017: 1-1-0, goal differential +2
- Oilers in October 2018: 0-2-0, goal differential -6
This is the worst start of the McLellan/Chiarelli era, but it's two games and we knew the start of the season was going to be difficult. Edmonton is finding out about its roster and what might be needed, and that has value. Talbot's 5-on-5 performance, McDavid in flight, and I did think young Evan Bouchard showed another night of improving before our eyes.
- On the road to: Sweden to play NJD (Expected: 0-0-1) (Actual: 0-1-0)
- On the road to: Boston, NYR, Winnipeg (Expected 1-2-0) (Actual 0-1-0)
- At home to: Boston, Nashville, Pittsburgh, Washington (Expected 1-3-0) (Actual 0-0-0)
- On the road to: Nashville, Chicago (Expected 1-1-0) (Actual 0-0-0)
- At home to: Minnesota (Expected 0-0-1) (Actual 0-0-0)
- Overall expected result: 3-6-2, 8 points in 11 games
- Current results: 0-2-0, 0 points after two games
Edmonton lost twice to superior teams, the game last night on the road. I do these looks at the monthly schedule because it gives us a road map for expectations. You should expect the first win of the season on Saturday. If Edmonton can't win there, I expect the whispers about Todd McLellan become audible murmurs. This schedule is basically the path chosen by the Donner party. Gordon Lightfoot's a wreck. Holy hell boys I might have to use Van Morrison lyrics before Halloween.
A fun Friday on the show, of course we'll talk Oilers and Eskimos. At 10 this morning, scheduled to appear:
- Steve Lansky, BigMouthSports. Oilers slow start, Matthews mania.
- Andrew Peard, Oil Kings PBP. The team is still playing well but the results aren't coming since the quick start.
- Matt Iwanyk, TSN1260. Eskimos can still make the playoffs in the west, but the room for error is gone.
10-1260 text, @Lowetide on twitter. Talk soon!


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Senior Management Team
Peter Tilley | Executive Director
Peter Tilley has been the Executive Director of the Ottawa Mission since June 2013. The Mission is one of Ottawa's oldest yet most progressive homeless shelters, providing a full range of services to the less fortunate in our community. Working closely with the board of directors and the senior management team, Peter has steered the organization through an ambitious strategic planning process that has seen the organization enhance mental health supports, addiction and trauma services, housing outreach and palliative care for those who are homeless.
Prior to The Mission, Peter served for 14 years as the Executive Director of the Ottawa Food Bank, leading that organization to become recognized as one of Canada's most visible and respected food banks.
A graduate of the Business Administration Program at Algonquin College (1984), Peter was a 2012 and 2017 Ontario Premier's Award nominee and has also been recognized as one of Algonquin College's top 10 Alumnus. He has also taught the Introduction to Non Profit Management course at Algonquin College part-time.
Peter previously worked as a manager in the recruitment industry and as a senior manager in the hotel industry.
He currently sits as a board member on several key boards, such as Ottawa Public Health, the Alliance To End Homelessness, Ottawa Inner City Health and Soldiers Helping Soldiers.
Jo McLean | Director of Programs
Jo has close to 30 years experience in the Social Services and Youth Justice sector working with high risk and vulnerable youth. She has held several positions over the span of her career, the majority of them in management. Jo made the leap to leave the youth sector in January 2011 and came to The Ottawa Mission as the Manager of Frontline Services. Two years later she was promoted to The Mission's Director of Programs and now oversees Addiction Services, Front Line Services and Client Services.
Lesley Horne | Director of Human Resources
Lesley joined The Ottawa Mission as Director of Human Resources in January 2014. She began her career as a Human Resources Generalist over 17 years ago working as HR Manager for one of North America's largest retailers. After 10 years, she was offered a position with a rapidly expanding family owned business where she was tasked with building the HR Function from the ground up. Lesley is a member in good standing of the Human Resources Professional Association.
Lynn Landis | Director of Healthcare Services
Lynn spent many years working with high risk and vulnerable youth and joined The Ottawa Mission team in 2014 as Manager of Client Services. In June of 2017, she stepped into the role of Director of Health Services and now oversees health services in the shelter and works closely with medical staff at Ottawa Inner City Health.
Aileen Leo | Director of Communications
Aileen has worked within the not-for-profit sector for over 25 years within the domains of advocacy, communications, public policy development and government relations, including over 10 years in senior management positions of progressive responsibility. Past positions have included the Director of Communications for the Canadian Healthcare Association and Executive Director of Government Relations and Public Policy for the Canadian Diabetes Association. Aileen also has a long history as an active volunteer with several local community organizations.
Timothy Meisenheimer | Senior Manager of Chaplaincy Services
Timothy started as Chaplaincy Services Senior Manager for The Ottawa Mission in 2018. His passion comes from his prior engagement as founding executive director at Capital City Mission (CCM) from 1999 – 2018 and his relationships with the most vulnerable in Ottawa, which confirmed his conviction that God is merciful and loves each of us.
Timothy is grateful to support his Mission colleagues to build connection and nurture relationships with residents and community members with care and dignity. These occasions offer the opportunity to support people through faith, hope, love, and encouragement through a heart with ears.
Before founding CCM, Timothy worked as a Pastor in Ontario and Alberta. Out west, he studied the book of Acts with his congregation to learn to be attentive to God's work in communities. Timothy has always been motivated by Matthew 25:" As you do unto the least of these you do unto Me"; and James 2: "Mercy triumphs over Judgment". Timothy was also greatly influenced by his mother, who lived her life by these verses.
Timothy also became a Grief Recovery Method specialist to support people who have suffered losses to experience their feelings, and thereby lighten their burden.
Garth Roy | Senior Manager of Finance
Garth grew up in Buckingham, Quebec and attended Heritage College where he received a diploma in Business Administration. He joined the Ottawa Mission in 1991.
Executive Chef Ric Watson | Director of Food Services
Chef Ric Watson has worked at The Ottawa Mission since 2002. He holds a certificate in Hotel and Restaurant Management and received his Chef's Red Seal certification from Camosun College in Victoria, B.C.
Chef Ric is responsible for managing the staff, students and volunteers who serve over 1300 meals every day to our shelter clients and community residents.
Beyond this, Chef Ric developed and implemented The Mission's unique Food Services Training Program (FSTP) which has been operating since 2004 and helps people who are homeless or at risk of being homeless gain the skills they need to work in a commercial kitchen and the confidence to reintegrate into the community. Chef Ric is also an active community volunteer and has served on several community organizations, including the Algonquin College Student Advisory Board, the Board of Just Food, and the Board of the Ottawa Canadian Culinary Federation (CCFCC) Ottawa branch. He has also received many awards, including: Ottawa Chef of the Year (2014); Maury Carp award for Community Development (2015); and Ontario Medal for Good Citizenship (2016).
Above all, Chef Ric lives every day by his personal motto: "You have to eat well to be well."

subset: commoncrawl


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NEW YORK: Thomson Learning, a provider of learning solutions and the second largest division of Thomson, has signed Kwittken & Company (KCO) as AOR.
Kwittken & Company will pursue a trade and national media relations campaign for the client.
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Aaron Kwittken, founder and CEO of Kwittken & Company, previously worked with Thomson Learning when the division rebranded from International Thomson Publishing in the 1990s.
"KCO's resident knowledge of our business and our company… combined with top notch issues and crisis counsel, makes them the perfect partner for us," said Adam Gaber, Thomson Learning VP corporate communications and public affairs, in a release.


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The Pequot Football Conference is realigning for the third consecutive season. The 19-team league is moving back to a three division format with six teams in each division (West, East, South).
Enfield, which will be a co-op team with Fermi, will play one more year in the league but won't be in a division. Enfield will be merging with cross-town rival Fermi and is scheduled to join the Central Connecticut Conference in the fall of 2016.
The Pequot Conference used three divisions in 2013 but went back to two division (Uncas, Sassacus) in 2014 after Housatonic/Wamogo dropped its varsity program. Avon is leaving the league to begin playing in the CCC this fall.
The three divisions are very similar to what they were in 2013. The differences are that SMSA/University moves to the West Division, Coginchaug moves to the East Division, the absence of Avon and Housatonic and Enfield playing as an independent team within the league.
West Division: Canton, Granby, Gilbert/Northwestern, SMSA/University, Lewis Mills and Nonnewaug
South Division: Valley Regional/Old Lyme, Morgan, North Branford, Hyde, Haddam-Killingworth, Old Saybrook/Westbrook
East Division: Coginchaug, Ellington/Somers, Windsor Locks/Suffield, Cromwell, Coventry/Windham Tech and Stafford/East Windsor
Each team will play five teams in their division plus four games against teams from other divisions. Teams were ranked based upon their results in 2014.
Canton, which won the Uncas Division last fall and earned a spot in the CIAC playoffs for the first time, is the top seed in the West Division. The Warriors (10-2, 9-0 Uncas) will play their five divisional opponents along with the top seed from South (Valley Regional) and the East (Coginchaug) along with the No. 2 seeds from the South (Morgan) and East (Ellington/Somers). Valley Regional (12-0, 9-0) won the Class S Large Division title last fall while Ellington/Somers (9-3, 8-1 ) lost in the Class M Small Division semifinals.
Canton is also looking for a 10th game to add to its schedule.
The Warriors are one of three teams in the state still looking for a new head coach. Canton athletic director Craig DeAngelis said that a five-person committee will interview three candidates in the coming week for the position. He declined to identify the candidates.
Canton is looking to fill the coaching spot once held by Paul Philippon, who resigned in December after three seasons due to the uncertain future for the program. With the graduation of eight seniors, there are just 18 returning players – eight juniors, nine sophomores and a freshman. Philippon has since returned to coach at Bristol Eastern, where he works.
Granby, Lewis Mills, Nonnewaug and Gilbert do have 10 games on their schedule because they picked up games with Enfield. Like Canton, SMSA/University currently has nine games on their schedule.
West Division tentative schedules
Subject to change
Sept. 11/12: SMSA/University
Sept. 18/19: open
Sept. 25/26: at Nonnewaug
Oct. 2/3: Gilbert/Northwestern
Oct. 9/10: at Morgan
Oct. 16/17: open
Oct. 23/24: Coginchaug
Oct. 30/31: at Ellington/Somers
Nov. 6/7: Lewis Mills
Nov. 13/14: at Valley Regional/OL
Nov. 20/21: open
Thanksgiving, Nov. 26: at Granby
Sept. 11/12: at Gilbert
Sept. 18/19: Enfield
Sept. 25/26: SMSA/University
Oct. 2/3: at Lewis Mills
Oct. 9/10: at Valley Regional/OL
Oct. 16/17: open
Oct. 23/24: Ellington/Somers
Oct. 30/31: at Morgan
Nov. 6/7: Nonnewaug
Nov. 13/14: at Coginchaug
Nov. 20/21: open
Thanksgiving, Nov. 26: Canton
Lewis Mills
Sept. 11/12: open
Sept. 18/19: at SMSA/University
Sept. 25/26: Gilbert/Northwestern
Oct. 2/3: Granby
Oct. 9/10: at Haddam Killingworth
Oct. 16/17: at Enfield
Oct. 23/24: open
Oct. 30/31: Old Saybrook/Westbrook
Nov. 6/7: at Canton
Nov. 13/14: Coventry/Windham Tech
Nov. 20/21: at Stafford/East Windsor
Thanksgiving, Nov. 26: Nonnewaug
Sept. 11/12: Granby
Sept. 18/19: Nonnewaug
Sept. 25/26: at Lewis Mills
Oct. 2/3: at Canton
Oct. 9/10: Hyde
Oct. 16/17: open
Oct. 23/24: at Windsor Locks/Suffield
Oct. 30/31: Cromwell
Nov. 6/7: open
Nov. 13/14: North Branford
Nov. 20/21: at SMSA/University
Thanksgiving, Nov. 26: Coginchaug
Sept. 11/12: at Enfield
Sept. 18/19: at Gilbert/Northwestern
Sept. 25/26: Canton
Oct. 2/3: SMSA/University
Oct. 9/10: at Old Saybrook/Westbrook
Oct. 16/17: open
Oct. 23/24: Coventry/Windham Tech
Oct. 30/31: Stafford/East Windsor
Nov. 6/7: at Granby
Nov. 13/14: Haddam-Killingworth
Nov. 20/21: open
Thanksgiving, Nov. 26: at Lewis Mills
Sept. 11/12: at Canton
Sept. 18/19: Lewis Mills
Sept. 25/26: at Granby
Oct. 2/3: at Nonnewaug
Oct. 9/10: North Branford
Oct. 16/17: open
Oct. 23/24: at Cromwell
Oct. 30/31: at Hyde
Nov. 6/7: open
Nov. 13/14: Windsor Locks/Suffield
Nov. 20/21: Gilbert/Northwestern
Thanksgiving, Nov. 26: open


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Fight Aging! Newsletter, August 6th 2012
August 6th 2012
The Fight Aging! Newsletter is a weekly email containing news, opinions, and happenings for people interested in aging science and engineered longevity: making use of diet, lifestyle choices, technology, and proven medical advances to live healthy, longer lives. This newsletter is published under the Creative Commons Attribution 3.0 license. In short, this means that you are encouraged to republish and rewrite it in any way you see fit, the only requirements being that you provide attribution and a link to Fight Aging!
- New Organ: Up to $15,000 For Social Network Engagement
- What is Aging?
- Premature Considerations of Immortality
- From a Recent Symposium on Cryonics and Dementia
- Discussion
- Latest Headlines from Fight Aging!
- The Brain is Plastic For Life
- Yet Another Theory to Explain Gender Differences in Longevity
- Engineering Viruses to Make a Better Targeted Cancer Therapy
- Tracking and Identifying Cancer Stem Cells
- Increased Resistance to Cellular Stress Common to Many Forms of Induced Longevity
- SENS Foundation Seeking Lysosomal Biology Team Lead
- Measuring Impaired Autophagy With Aging in the Pancreas
- The Point of Slowing Aging
- A Comparative Cellular and Molecular Biology of Longevity Database
- Modest Success in a Cancer Vaccine Trial
The New Organ 100 initiative continues to attract matching funds:
"The New Organ Prize is a technology prize aimed at speeding development of tissue engineered complex organs, founded by the Methuselah Foundation. To win, a competitor must build a complex organ from a patient's own stem cells, transplant it, and have it function for two years - without making use of present stepping stone technologies such as decellularization that still require a donor organ. Start with cells and end up with patient-matched organs: that is the vision.
"One of the projects currently undertaken by the New Organ volunteers is the New Organ 100 initiative, focused on crowdsourcing the first stage of prize fundraising, raising awareness, and building support in the large community of organ donors, organ recipients, and their supporters.
"As matters proceed, the New Organ Prize continues to attract matching donations and incentives. The latest is an offer by investor Michael Matula: for every like or share on Facebook, or follower on Twitter, he will donate $1 to the prize fund - up to $15,000. In an ideal world, every reader here would think enough of the initiative to head on over and donate a modest amount, or start a fundraiser and talk a few friends into supporting the initative. If you're not up for that, however, then consider stretching your mouse fingers so far as to like the New Organ 100 page."
What is aging? Like art, we know it if we see it. But once down to the detail level of evolutionary fitness, population mortality rates, and biological mechanisms, a consistent definition becomes a little challenging:
"In 1991, the book Evolutionary Biology of Aging offered the following definition of aging: a persistent decline in the age-specific fitness components of an organism due to internal physiological deterioration (Rose, 1991). This definition has since been used by others a number of times. However, it was only a modest generalization of a definition proffered by Alex Comfort over three editions (1956-1979) of his key book The Biology of Senescence (Comfort, 1979): "a progressive increase throughout life, or after a given stadium, in the likelihood that a given individual will die, during the next succeeding unit of time, from randomly distributed causes." ... Yet a mere definition does not necessarily tell a scientist what causally underlies the phenomenon that is so defined. The latter issue is much broader, implicitly raising fundamental scientific questions regarding mechanisms."
It seems there has been a fair degree of discussion on the topic of immortality of late, more than is usual:
"For whatever reason, a number of public voices seem to be talking about immortality all of a sudden, largely meaning physical immortality in the sense of immunity to aging but vulnerability to fatal accidents. Topics ebb and flow like tides, I suppose, the signs of many hidden connections that underlie our culture - that grand conversation of innumerable threads held in the myriad communication channels available to us. ... Immortality can be a useful term - such as on the occasions on which you want to plant a flag a long way out in the discussion and make waves. It is, I think, becoming less useful with time, however. So many people use it without meaning or with so many varied and half-thought meanings that it is, like 'anti-aging', becoming more harmful than helpful. Too much baggage, too many charlatans of various types hitching their carts to the bandwagon.
"Putting in serious time and thought on physical immortality - $5 million here and $5 million there adds up pretty quickly - seems to me to be premature. There is a great deal of work that lies between here and first generation rejuvenation biotechnology, something that will allow us to live additional decades in good health, never mind what comes after that. The rise and rapid obsolescence of many massive industries in medicine will happen over the next fifty years in order to extend the outer limits of human health and life span far beyond the present century-and-a-bit. Each of those churning engines of progress will see millions of individuals working in hundreds of competing companies, a world of intricate detail.
"The result of all of that? Possibly humans that can live for two centuries or more before hitting as-yet unknown limits to presently envisaged biological repair technologies. This is a drop in the ocean of time. But that will give a hundred years of grace in which to work feverishly on the next generations of technology: replacements for biological systems, improving on the ways to repair and rebuild our cells, merging with our machines as those machines become ever smaller and more capable. The world of a century and a half from now will be as distant and strange and capable to us as our tools and society would seem to a 18th century peasant.
"My point is that many transformative, world-sweeping changes brought by advancing technology will occur in the decades between now and even a mere hard-fought doubling of the human life span. We'll be starting in earnest to settle the Moon and Mars by then. Our machines will be able to think for themselves. Desktop and motile nanofactories will be capable of fabricating everything from houses to gene therapies from raw materials. A sea of historical and cultural manuscripts will be written on those changes, and still fail to easily capture the scope of the way in which the world changes.
"And then it starts over again, ever building new and greater edifices as we push on to overcome the next set of limits to the human condition. All of this grand and complex near future of increasing longevity and massive change seems far more worthy of thought than immortality, given the length of the road between here and there, and how much has to be done to even start talking seriously about lives of tens of thousands of years."
The folk of the Institute for Evidence Based Cryonics hosted a symposium on cryonics and dementia last month, and some of the presentation materials are available online:
"Cryonics is the low-temperature preservation of the deceased, as rapidly as possible after death so as to preserve the fine structure of the brain before it can be damaged or decay. The body, or at least the head, are also preserved - but that is largely incidental to the real purpose, which is to store the mind encoded in the structure of neural tissue. For so long as that mind exists in low-temperature storage it has time to wait out progress in technology, the dawn of an age of medical molecular nanotechnology, and advanced tissue engineering capable of restoring that brain to live in a new body. If you have the technology to de-vitrify a brain whilst maintaining its mind, so the thinking goes, then building a body from stem cells is pretty straightforward by comparison.
"In any case, my point here is the the focus of cryonics is the brain, its structure, and the mind. Threats to the fabric of the mind are of greater importance than threats to the rest of the body in this way of looking at the world, as there exist a range medical conditions that can destroy your mind well prior to death, placing you just as far beyond help as if you burned to death, were lost at sea, or simply buried."
The highlights and headlines from the past week follow below. Remember - if you like this newsletter, the chances are that your friends will find it useful too. Forward it on, or post a copy to your favorite online communities. Encourage the people you know to pitch in and make a difference to the future of health and longevity!
Friday, August 3, 2012
We have a great deal more control over the age-related decline of the brain than was once thought - "use it or lose it", and the ability to affect change through challenging the mind. Yet it remains the case that new biotechnology and medicine will be required to get to where we want to be, a world without the risk of dementia, fuzzy memory, and slow cognition. Still, the plasticity of the aging brain is encouraging: "There is growing evidence that, beyond what was previously believed, the adult human brain is remarkably malleable and capable of new feats - even in the last decades of life. In fact, new experiences can trigger major physical changes in the brain within just a few days, and certain conditions can accelerate this physical, chemical and functional remodeling of the brain. ... We used to think that the brain was completely formed by development and its basic structure didn't change much in adults, but as research went on we discovered that wasn't true, at least in the cerebral cortex. We now know that an underlying portion of the brain called the thalamus, which feeds the cortex information from our senses, is also remarkably plastic. ... There is no evidence that there is any part of the adult brain that is not plastic. But studies indicate that some aspects of musical training, such as the ability to perceive temporal patterns, require the brain to be trained during early developmental periods when its primed for certain types of stimuli. For other aspects of musical development, such as the ability to perceive and repeat a sequence of tones, it's irrelevant whether you've had that experience and training early in life. ... The brain is plastic for life. The fundamental thing that determines how much [persons with brain disorders] will improve is the level of their initial impairment, but not their age."
Friday, August 3, 2012
There is no shortage of theories as to why women live longer than men - an apparently simple question, but one balanced on such a mountain of complex data and partial knowledge that it cannot be definitively answered at the present time. Here is another theory for the stack: "Mitochondria are inherited only from mothers, never from fathers, so there is no way to weed out mutations that damage a male's prospects. ... [Researchers] analysed the mitochondria of 13 different groups of male and female fruit flies. Mitochondria, which exist in almost all animal cells, convert food into the energy that powers the body. ... the results point to numerous mutations within mitochondrial DNA that affect how long males live, and the speed at which they age. ... Intriguingly, these same mutations have no effects on patterns of ageing in females. All animals possess mitochondria, and the tendency for females to outlive males is common to many different species. Our results therefore suggest that the mitochondrial mutations we have uncovered will generally cause faster male ageing across the animal kingdom. ... They suggest this is because there is no evolutionary reason for the faults that affect males to be picked up - because mitochondria are passed down by females. ... If a mitochondrial mutation occurs that harms fathers, but has no effect on mothers, this mutation will slip through the gaze of natural selection, unnoticed. Over thousands of generations, many such mutations have accumulated that harm only males, while leaving females unscathed."
Thursday, August 2, 2012
Some viruses show promise in terms of preferentially attacking cancer cells - but they can be engineered to be far more effective in the role of therapeutic agent: "Parvoviruses specifically kill cancer cells and are already in the clinical trial stage for treating malignant brain tumors. However, they can also infect normal cells - without doing any harm to them - so a large portion of viruses is lost during therapy. [Researchers] have now modified parvoviruses in such a way that they initially lose their ability to infect cells. In a second step, they equipped the viruses with a molecular key for infecting cancer cells. ... the researchers chose H1 parvoviruses, which normally infect rodents but are also infectious for human cells. H1 viruses kill tumor cells on the basis of their natural properties, i.e., their genetic material does not need to be modified for them to do so. ... The viruses exclusively destroy cancer cells. But with the same efficiency that they infect cancer cells, they also infect healthy cells. There they do not cause any damage and cannot replicate, but we lose a large portion of therapeutic viruses every time ... To solve this problem, the researchers [first] modified the genetic material of the virus in such a way that it loses its ability to infect cells. In a second step, this non-infectious virus was equipped with a molecular key for cancer cells. ... This is first evidence that it is basically possible to modify properties of H1 according to a plan. We will surely need several more attempts in order to target the viruses more specifically to cancer cells in the second step. We also already have ideas how to further enhance the infectious capacity and the potential to destroy cancer cells."
Thursday, August 2, 2012
Any commonality in present in varied types of cancer is important, as it provides a potential path to a comparatively low-cost, robust suite of therapies that work for many cancers - and a robust cancer cure is an important component of any future rejuvenation biotechnology toolkit. Here researchers add some weight to the cancer stem cell hypothesis: "Cancer researchers can sequence tumour cells' genomes, scan them for strange gene activity, profile their contents for telltale proteins and study their growth in laboratory dishes. What they have not been able to do is track errant cells doing what is more relevant to patients: forming tumours. Now three groups studying tumours in mice have done exactly that. Their results support the ideas that a small subset of cells drives tumour growth and that curing cancer may require those cells to be eliminated. It is too soon to know whether these results - obtained for tumours of the brain, the gut and the skin - will apply to other cancers, [but if they do], there is going to be a paradigm shift in the way that chemotherapy efficacy is evaluated and how therapeutics are developed. ... Underlying this scenario is the compelling but controversial hypothesis that many tumours are fuelled by 'cancer stem cells' that produce the other types of cancer cell, just as ordinary stem cells produce normal tissues. ... The papers provide clear experimental evidence that cancer stem cells exist ... They have made a major contribution to validating the concept of cancer stem cells. ... Researchers are already busy hunting for ways to kill these cells; now they have more tools to tell whether such a strategy will work."
Wednesday, August 1, 2012
An open access paper, and an example of the way in which researchers are closing in on common mechanisms that explain the operation of many diverse ways found to extend healthy life in laboratory animals: "Many mutations that increase animal lifespan also confer stress tolerance, suggesting that cytoprotective mechanisms underpin the regulation of longevity. It has not been established, however, whether the induction of individual cytoprotective pathways is essential for lifespan extension, or merely correlated. To establish whether the regulatory pathways for the induction of cytoprotective responses are key in the extension of lifespan, we performed an RNAi screen for gene inactivations that decouple the activation of cytoprotective pathways from xenobiotic stimuli that normally induce them. The screen identified 29 genes that constitute the regulatory cascades of the unfolded protein response, oxidative stress response, and detoxification. ... If cytoprotective responses contribute directly to lifespan extension, inactivation of these genes would be expected to compromise the extension of lifespan conferred by decreased insulin/IGF-1 signaling, disruption of mitochondrial function, or caloric restriction ... We find that inactivation of 25 of 29 cytoprotection-regulatory genes shortens the extension of longevity normally induced by decreased insulin/IGF-1 signaling, disruption of mitochondrial function, or caloric restriction, without disrupting normal longevity nearly as dramatically. These data demonstrate that induction of cytoprotective pathways is central to longevity extension."
Wednesday, August 1, 2012
A research position is open at the SENS Foundation: "SENS Foundation is hiring for our research center located in Mountain View, CA. We are seeking a team lead for our LysoSENS group to work both on established projects and new independent lysosomal-based research geared towards the SENS mission ... Qualified candidates will have a Ph.D. in the chemical/biological sciences and at least 5 years of work experience that must include prior project management experience. Duties will include bench work, management of a small team of lab researchers, the preparation of grant proposals, internal and external progress reports, individual and collaborative publication. The project lead will develop, interpret and implement standards, procedures, and protocols for the LysoSENS research program and may collaborate on determining strategic directions in the research program. Bench experience should include standard laboratory techniques, including but not limited to standard cell biology/biochemistry/molecular biology techniques. Good fundamental laboratory skills to include safety, microbial and mammalian cell culture. Experiments may include cell culture, transfection, organelle (lysosomal) purification and imaging, microscopy, protein production and analysis in addition to supervisory duties. As a project lead, candidates must have the ability to design, develop and direct experiments that establish the viability of the SENS mission and chosen therapeutic goals."
Tuesday, July 31, 2012
Autophagy is the important collection of processes that break down damaged cellular components and unwanted metabolic byproducts. More autophagy improves the health of the organism and extends longevity, while less autophagy leads to the reverse. Boosted autophagy appears to contribute strongly to a number of life-extending interventions, including calorie restriction, and researchers have achieved such goals as reverting aged liver function to youthful levels by increasing the effectiveness of autophagic processes. Unfortunately, autophagy declines with age as the cellular components that carry out the process become damaged and overwhelmed by metabolic waste products. Here researchers measure the impact of reduced autophagy with age in the pancreas: "Type 2 diabetes is characterized by a deficit in β-cell function and mass, and its incidence increases with age. ... Impaired or deficient autophagy is believed to cause or contribute to aging and age-related disease. Autophagy may be necessary to maintain structure, mass, and function of pancreatic β-cells. In this study, we investigated the effects of age on β-cell function and autophagy in pancreatic islets of 4-month-old (young), 14-month-old (adult), and 24-month-old (old) male Wistar rats. We found that islet β-cell function decreased gradually with age. Protein expression of [autophagy markers] exhibited a marked decline in aged islets. The expression of Lamp-2, a good indicator of autophagic degradation rate, was significantly reduced in the islets of old rats, suggesting that autophagic degradation is decreased in the islets of aged rats. [Markers] of mitochondrial and nuclear DNA oxidative damage exhibited strong immunostaining in old islets. Analysis by electron microscopy demonstrated swelling and disintegration of cristae in the mitochondria of aged islets. These results suggest that β-cell and autophagic function in islets decline simultaneously with increasing age in Wistar rats, and that impaired autophagy in the islets of older rats may cause accumulation of misfolded and aggregated proteins and reduce the removal of abnormal mitochondria in β-cells, leading to reduced β-cell function. Dysfunctional autophagy in islets during the aging process may be an important mechanism leading to the development of type 2 diabetes." Reversing the decline in autophagy by restoring lysosomal function is a part of the SENS vision for rejuvenation biotechnology.
Tuesday, July 31, 2012
This abstract encapsulates the point made by advocates of slowing aging through metabolic manipulation by drugs or other means - that it is a far better approach than the present dominant methodologies of treating various end-stages of aging separately, and by patching over the symptoms rather than treating root causes: "Atherosclerosis, hypertension, obesity, diabetic complications, cancer, benign prostate hyperplasia, Alzheimer and Parkinson diseases, age-related macular degeneration, osteoarthritis, osteoporosis, and seborrheic keratosis are strongly associated with aging, implying a common underlying process. Each disease is treated separately and, in most cases, symptomatically. Suppression of aging itself should delay or treat all age-related diseases, thus increasing healthy life span and maximal longevity. But, is it possible to slow down aging? Recent evidence indicates that the target of rapamycin signaling pathway is involved in cellular senescence and organismal aging. Preclinical and clinical studies demonstrated the therapeutic effects of rapamycin in diverse age-related diseases. One simple reason why a single drug is indicated for so many age-related diseases is that it inhibits the aging process."
Monday, July 30, 2012
Researchers recently announced a database of interesting material on the biology of longevity - one of a growing number of publicly available online databases in this field: "Discovering key cellular and molecular traits that promote longevity is a major goal of aging and longevity research. One experimental strategy is to determine which traits have been selected during the evolution of longevity in naturally long-lived animal species. This comparative approach has been applied to lifespan research for nearly four decades, yielding hundreds of datasets describing aspects of cell and molecular biology hypothesized to relate to animal longevity. Here, we introduce a Comparative Cellular and Molecular Biology of Longevity Database [as] a compendium of comparative cell and molecular data presented in the context of longevity. This open access database will facilitate the meta-analysis of amalgamated datasets using standardized maximum lifespan (MLSP) data (from AnAge). The first edition contains over 800 data records describing experimental measurements of cellular stress resistance, reactive oxygen species metabolism, membrane composition, protein homeostasis, and genome homeostasis as they relate to vertebrate species MLSP."
Monday, July 30, 2012
German researchers trialing a generally applicable cancer vaccine technology find that it improves on chemotherapy, but remains a long way from a cure. Still, this is generally how matters proceed: first results are only first results, and much improvement lies ahead. "Researchers [have] published the results of two clinical studies using the kidney-cancer vaccine IMA901 ... It is composed of ten synthetic tumor-associated peptides (TUMAPs), which activate the body's own killer T-cells against the tumor. Unlike chemotherapy, this process targets the body's immune responses and mobilizes them to attack the cancer. The studies show that this active immunization against cancer can be successful and extend the life of a patient for longer than even the latest chemotherapy techniques - with far fewer side-effects. ... All of the medications previously used have brought about a clear improvement in reducing tumor growth in cancer of the kidneys, but they did not lead to the desired extension of the patient's life and certainly did not cure the patient. ... The study shows that in kidney-cancer patients with documented T-cell reactions against two or more tumor-associated peptides, the immune reaction and clinical progress were clearly linked. That confirms the hypothesis that cancer treatments can be further developed by broadly activating the immune system against various target structures on the surface of the tumor. ... The principle applied here - of active immunization against cancer antigens previously identified in cancer cells - can be used against practically all types of cancer. ... researchers have published similarly successful clinical studies in the case of bowel cancer [and] prostate cancer. Immatics is currently carrying out studies on treatments for glioblastoma [a common and malignant brain tumor] and further studies for treating liver cancer and ovarian carcinoma are in the pipeline."


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Tony Lee
March 5, 2014
At a bilingual elementary school in Washington, D.C. on Tuesday, President Barack Obama unveiled his $3.9 trillion budget that calls for Congress to pass amnesty. The budget, which is already a month late, calls for immigration reform that provides a pathway to earned citizenship for the nation's illegal immigrants.
"The Senate has acted to pass a bipartisan immigration reform bill that is worthy of support," Obama wrote in his introductory budget message. "It is time for the House of Representatives to finish the job."
Obama delivered his remarks at Powell Elementary School, which is described as a "small, community-based school" that is a "finalist for Dual Language School of the Year."
Read more
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The confinement in our homes is forcing millions to stop abruptly, cancel all our plans, and take time to look in the mirror.
Media commentator Tony Watkins introduces new website EngagingMedia.info. "We need to encourage more talented Christians to embark on media careers."
Are Christians understanding the underlying messages of our media-saturated world? How good are they at analysing films and series or using the social networks?
"Christians were quick to make use of the printing press and radio and television, but on the whole we were rather slower making good use of the internet", thinks Tony Watkins, a speaker and writer about media based in the UK.
Alongside Norwegian Journalism professor Lars Dahle, he is coordinating EngagingMedia.info, a new online platform which brings together resources to help Christians engage with all kind of media.
Video, blog posts and specialised guides help users to analyse messages of films, tv programmes and social networks. These resources come from experts from all over the world.
The idea was born within the Lausanne Movement: "At the Cape Town Congress in 2010, we were acutely aware of a huge global need for Christians to be equipped to engage with the media." That was followed-up with international consultations in the following years.
So who can profit from the project? "Christians from all over the world who have some involvement in media", the coordinators say. "That could be people who work in the mainstream media, or in some kind of Christian media ministry", but the project is not just for the 'professionals'.
"Any Christian who ever watches a film or TV should want to engage with the messages, many Christians are on social media, so there's a sense in which we all have some involvement in both secular media and media ministry", argues Watkins.
Watkins responded some other questions in this interview with Evangelical Focus.
Question. The project seems to encourage three main areas of reflection: media awareness, media presence and media ministries. Why these three approaches?
Answer. Western society has been saturated with media for a long time, and that's increasingly true in the global south, too.
India, for example, is in the middle of a project to take broadband to all 750,000 villages. That will bring much more media, including western media, into the lives of rural people. But Christians have not always very good at responding to the mainstream media very constructively – our tendency is to either be unthinkingly critical of it or unthinkingly accepting. Both approaches are very flawed.
So there's an enormous need, right around the world, for Christians to think much more deeply about the media we encounter every day. We long for Christians to be able to really understand the media messages they encounter. It will help us in our discipleship – so that we're not conformed to the pattern of this world (Romans 12:2) – and it will help us in our evangelism, because it's the media which shapes the thinking of the people we meet every day. That's 'media awareness'.
'Media presence' is about a Christian presence within the mainstream media, which in the west, at least, is profoundly secular. Christians who go into the media often feel very isolated: their colleagues are suspicious of them because they're Christians, and other Christians are suspicious because they work in such an apparently 'godless' arena. So we need to learn to support and disciple such people, who are in a very strategic situation, and we need to encourage more talented Christians to embark on such careers. One day we will have more people like Pete Docter at Pixar making fantastically positive contributions to the culture. We also need to equip Christian leaders to be able to deal with the media and to have a voice within the media.
'Media ministries' are more obvious in many ways. Christians have always used whatever media were available to communicate the good news of Jesus Christ. We were quick to make use of the printing press and radio and television, but on the whole we were rather slower making good use of the internet. But now the technology to make high quality media is cheap and easily available, and social media has opened up lots of new channels for us to communicate our message.
So now we're at a point where we need to do some good thinking about how we make best use of the opportunities we have, not just within established media ministries, but within every Christian organisation and every church. Now we all have a media ministry, so how can we do it well?
Q. More and more young Christians are becoming trained journalists, media content producers, etc, in Europe and other continents. Do you think they are prepared to connect their biblical faith and their daily work, in a context in which secularism and very liberal ideologies are predominant?
A. Some are, but it is very hard – at least in the secular western world – partly because there are not many of them. If we could encourage more people into the area, and find ways for them to develop supportive networks, it would get somewhat easier. But the challenges to Christian faith would still be significant.
At the moment, there seems to be an enormous appetite in the west for entertainment and factual media which go right against a historically orthodox understanding of the Bible. So it is hard. But Christians who are right in the heart of the journalism world or the entertainment industry can give a different perspective and help their colleagues to question the assumptions that they're working with.
It is so important that we pray for such people, and find ways to equip them to de distinctively Christian in what is often a hostile environment. I long for more talented Christians to see their work in missional terms and choose to go into the mainstream, rather than automatically trying to find a Christian organisation to work with.
Q. Is it somewhere in your future plans to help create a big cooperative network of Christian Communicators working in different fields and countries?
A. Absolutely! The Lausanne Media Engagement Network is already connecting people in media ministry with Christians in the mainstream media and with those who have expertise in media awareness. Christians in each of the three areas need to at least know about each other and pray for each other.
But if we're really going to be effective, we need to develop partnerships which allow us to share our resources, gifts, ideas, best practice, and so on. A network which connects up all three strands, as we're trying to do, will enable us to learn and grow and innovate in ways that wouldn't have happened otherwise. It's still a small network at the moment, but now that EngagingMedia.info is up and running, we're growing quite fast.
Q. Finally, do you think most Christians know what the Lausanne Movement is? How would you describe it briefly to someone who has not heard about it yet?
A. It's a global missions movement which started with the first International Congress on World Evangelization, led by Billy Graham and John Stott, in Lausanne, Switzerland, in 1974.
There have been two more international congresses since then: in Manila in 1989 and in Cape Town in 2010. The influence on the evangelical church in general, and the mission world in particular, is enormous. Its aim is to 'connect influencers and ideas for global mission, with a vision of the gospel for every person, an evangelical church for every people, Christ-like leaders for every church, and kingdom impact in every sphere of society.' It's an exciting vision to be part of.
If you want to comment, or
The Director of the Jubilee Centre (Cambridge) analyses the impact of the financial crises on families, and the future of the workplace in a connected world, from a Christian perspective.
Jim Memory analyses the main issues that have changed Europe in the 2010-2019 decade. How should Christians live in a continent that has lost its soul?
An interview with the socio-political representative of the European Evangelical Alliance about how evangelical Christians work at the heart of the European Union.
Are Christians called to make a difference in environmental care? What has creation care to do with "loving our neighbours"? An interview with the Global Advocacy and Influencing Director of Tearfund.
Christians joined the Evangelical Alliance Week of Prayer in dozens of European cities as local churches came together to worship God.
Photos of the student conference that brought together 3,000 European Christians in Germany. 'Revive our hearts, revive our universities, revive Europe'.
Dave Patty shares about the notion of parenting children on God's behalf.
"Prayer is like a fire. One spark that someone prays should ignite a passion in someone else". Mike Betts leads the network of churches Relational Mission.
A video summary of the student conference that gathered 3,000 in Karlsruhe, Germany. 6 days in 6 minutes.
Opinions expressed are those of their respective contributors and do not necessarily represent the views of Evangelical Focus.


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Delhi, the national capital of India, is a major tourist spot for tourists for Indians and people of other countries as well. The places to visit while in Delhi with friends or family include the historical monuments, the gardens, market places, the huge malls for shopping, museums etc.
A proper trip to Delhi should not be less than a week and still, there will be a lot left to experience and see. In a place where one can visit alone, with a group of friends or with family. There are different tourist attractions for any type of visitors. Besides the numerous tourist attractions in Delhi, a tourist should also try out the many cuisines and famous restaurants famous for different kinds of meals and snacks. It is such a wonderful place to shop as there are so many numerous options for shopping whether it is in malls or the local markets. A common feature that has come up in malls nowadays is to have to have a haunted house in it. This can commonly be seen in many of Delhi malls. Few names are :
- Scary House in City Square Mall in Rajouri Garden
- Hidden House – Escape Rooms in Hauz Kauz
- City Centre Mall in Rohini
India, a place where many haunted places are believed to be there. Few of these haunted places in India are mentioned below:
- Bhangarh Fort: The first on any piece was written on a travel blog of haunted palaces in India would be the Bhangarh Fort. Its located at Alwar in Rajasthan. It's a popular belief that this fort is haunted. Tourists are forbidden to be inside the fort post sunset.
- Shaniwarwada Fort: The belief goes that a ghost of a 13-year-old haunts this fort in Pune, Maharashtra. The story goes that, this boy was Prince Narayan who was killed as he was the heir to the throne of the Peshwa dynasty.
As the stories go, there are few places which are considered as haunted places in Delhi. Lothian Cemetery is considered to be the most haunted place in Delhi. Many stories by many people are the reason for this. One of the scariest stories of this haunted place is that British soldier walks around with his head in his hand. Another, a house in Lajpat Nagar – Part 3 is said to be isolated for a long time because of a fight between the two brothers who are joint owners. Being isolated for many years now, stories of it been haunted come into being. Few of the other places to be considered haunted in Delhi are mentioned below:
- Malcha Mahal: This is a hunting lodge from during the Tuglaq years in Delhi. It is located in present-day Chanakyapuri. Also, known as Wilayat Mahal named after Begum Wilayat Mahal of Awadh. The Begum committed suicide in September of 1993 and visitors to this place they that they have a sensation of some energy hitting them. The property had been handed over to the Government of India in the year 1985
- Jamali Kamali: This is the tomb of two Sufi saints from the 16th century namely Jamali and Kamali. It is located in the Mehrauli Archaeological Park. According to reports, voices are heard inside the central dome
- Sanjay Van: This place is the burial place for many of the Sufi saints and also a cremation place. People have felt both negative and positive energy while taking a walk there. The location of Sanjay Van is Qutub Institutional Area.
- Feroz Shah Kotla Fort: This fort date backs to the Tughlaq era. It has many shrines inside it. Visitors paste letters in the walls in this place as it popularly believed that djinns/genies visit this fort and wishes written in the letter are fulfilled. Some people also leave milk and light diyas for the djinns.
- Dwarka Sector 9: The metro station: Among the more recent places to be considered haunted in Delhi is the metro station at Sector 9, Dwarka. Many people have claimed that they have seen a woman come and go. They claim that she just appears and disappears. Some people also have claimed that she is dressed in a white saree and follows a car. Others say that they while they are walking there, they feel the presence of someone walking with them.
- Delhi Cantt: It's quite strange but many people have claimed to have seen a woman in a white dress in Delhi Cantt area who tries to ask lift from cars that pass by and some also say they have seen the woman sitting in their car.
Noida, a satellite city of Delhi is now a developed area with so many existent and upcoming commercial and residential places. But people do claim that there are some haunted places in Noida. Few of these are:
- The place where the well-known Arushi and Hemraj murders had taken place is said to be haunted. The place is in Noida Sector -35. People say that they have seen a hooded figure standing on the roof of the apartment. Many of the flat owners have also left their flats and gone to live somewhere.
- The Hindon river in Noida is another place which has tales of being haunted. Old people of the village have said that they have felt odd and spooky feelings in the area near the river. Especially, after sunset, hardly anyone can be seen at the river bank.
- In the Noida expressway which is considered a marvel in the roadways sector, many people say that they have seen a lady crossing the expressway but they just pass through her and nothing happens to her and when they look again, she is not there.
- A shoe factory named as the Phoenix Shoe factory is next in our list of places considered haunted in Noida. It is in Sector 60 in Noida. Some years ago, there was a large fire in the premises of the factory and some people could not escape from the fire as they were not able to come out of the factory. Around 200 people were declared dead in the incident which included women and children. Now, the place has iEnergizer. But now, people claim to have listened to screams of women and children in the premises.
Read More: Things you must do when you are visiting Bali


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Introducing A New Novel
By Conrad Bishop and Elizabeth Fuller
June 10th 4:00 pm
Main Stage West is proud to host a book launch of Conrad Bishop and Elizabeth Fuller's novel Galahad's Fool. They will read from their novel, present a short comedy sketch, and talk about their work.
Admission is $10
Admission may be credited against a $15 book purchase.
THE STORY, "Galahad's Fool"
A year after his co-creator Lainie's death, an acerbic veteran puppeteer struggles to build a solo show. But what Albert Fisher intends as a lightweight spoof turns sharply personal, and he births a raw myth of loss. His aging Galahad, bereft of youthful vision, launches a second mad quest for the Holy Grail. To follow, his wife secretly disguies herself as their frail, androgynous Fool. As the show evolves, Albert finds kinship with his grieving hero and risks new love.
THE AUTHORS, Conrad Bishop and Elizabeth Fuller
Leaving college teaching 47 years ago to go on the road with two kids bouncing in the back of a van, Bishop & Fuller know their grizzled puppeteer hero well. As playwright/actors since 1969, they have criss-crossed the USA-over 3,500 performances-and their plays have been produced Off-Broadway and with regional theatres, plus countless tours by their ensemble, The Independent Eye. Their books include a novel, a memoir, and two anthologies of their plays. In June'17, they completed a two-year national tour of their puppet/actor KING LEAR with a run at Main Stage West.


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Threads reviews McCall's Pattern 6656. This unlined jacket with four views and two length variations has front princess seams, lower sleeve bands, and a dramatic shawl collar exposing the fabric's…
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Just a bit of refreshing, crisp mint to keep your palate cool while you enjoy 100% hemp-derived CBD. With the Glacier CBD Tincture by Nu-X, you can savor a satisfying CBD experience along with a light frosting of mint flavor on your tongue, all in a natural, versatile product that is potentially perfect for your CBD goals. Enjoy full spectrum CBD with a hint of mountain freshness, and grab the Glacier CBD Tincture by Nu-X today!
DISCLAIMER NOTICE: PLEASE READ CAREFULLY. This product is being distributed in U.S. interstate commerce in accordance with the 2018 Agricultural Improvement Act applicable to hemp-derived products. The product(s) accompanying this order are being sold to you at your request. BUYER ASSUMES ALL RESPONSIBILITY FOR COMPLIANCE WITH STATE OR LOCAL LAWS, ORDINANCES, TAX OBLIGATIONS, OR LICENSING REGULATIONS OR PROHIBITIONS. Seller is encouraged to seek legal advice if unsure as to the status of state or local laws relating to further distribution or retail sale of these products.
BUYER ASSUMES ALL RISK. SELLER MAKES NO WARRANTY, WHETHER EXPRESS OR IMPLIED, INCLUDING WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. These products are sold exclusively for adult use as a recreational product. These products are not intended by Seller for use in the diagnosis, cure, mitigation, treatment or prevention of any disease or medical condition. These products are not intended by Seller to affect the structure or function in the body (whether human or animal). Seller makes no claims regarding any therapeutic benefits associated with use of these products. Buyer understands that these products are manufactured by an independent third party (or parties) and Buyer agrees that Seller is not responsible for any marketing, advertising, promotion or labeling of any third-party products, including any express or implied claims allegedly made by any third-party manufacturer of such products.
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Cooks are discovering that agave nectar, Indian jaggery and other natural sweeteners have nuanced flavors that white sugar doesn't; plus, unprocessed sweeteners may be richer in minerals and less likely to cause spikes in blood-sugar levels. In Mani Niall's cookbook, Sweet!, he champions these ingredients. His pleasantly dense cranberry-studded scones, for instance, get a toffee like flavor from light brown turbinado sugar, which has large, crunchy crystals. Sugar in the Raw is a good brand. Great Breakfast Dishes
How to Make It
Preheat the oven to 425° and line a baking sheet with parchment paper. In a bowl, whisk the flour, oats, baking powder, salt and 3 tablespoons of the sugar. Using a pastry blender or 2 knives, cut in the butter until the mixture resembles coarse meal. Mix in the cranberries and orange zest. Stir in the 1/2 cup of buttermilk until a stiff dough forms; knead until it just comes together.
On a floured surface, pat the dough into a 3/4-inch-thick round and cut into 8 wedges. Brush with buttermilk. Sprinkle the remaining sugar on top. Transfer to the baking sheet and bake in the center of the oven for 17 minutes, until lightly browned. Transfer the scones to a rack and let cool slightly. Serve warm or at room temperature.


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Mayor of Montreal (where the stage is disputed), Gérald Tremblay, is confident it can convince the manager to continue with the trial. To do so, had a two-hour meeting with Ecclestone, outlining his views on the subject. It was not disclosed the content of the conversation, but Tremblay returned with great hope that the Canadian stage remains in the category.
"We had a better understanding of the problems that were way. We still have much work to be done to evaluate all options, but it is still possible to have a GP in Montreal in 2009 and subsequent years, "said local mayor
I knew Bernie Ecclestone is doing the possible and impossible for the GP of Canada back ...... Eclestone Bernie is the "common sense of Formula 1 has always fought for the category grow ... with no class always fights ... united all teams have a lot of respect and affection by Bernie Eclestone


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I find it so difficult to make room for just some post in time during the semester and the holiday came and it was kind of "geek" just to stick with the computer to do all the assignment left with some review on the last semester. That is why I decided to relax a bit before head back to the game!
Enough of going around the bush, here is my last semester reviews:
– Finally I could understand some about French culture, lifestyle and its elegance. Social life is appreciated and people tend to enjoy the time talking, enjoying the food, appreciate the art and fashion, which is very distinct from all Western countries. Normally, the concept "Time is money" usually refers to the developed Western culture, where life is so busy and people tend to be workaholic and deal-oriented. I found French is a great mixture of Western and some Eastern culture from this perspective, who treasure the social time and have a sense of life enjoyment.
– About the language, I did attempt to speak French. At first, it was so frsutrating to learn while I have difficulties in daily life and social attitude pressure towards my terrible French is so high that I felt lost for a short while. However, after trying harder and harder, I realize that despite the difficulty, it was so fun while learning a new language, especially in its own native-speaking-country. People tend to become more open and friendly to you and become so helpful, that's what encourage me to learn by myself the language everyday.
– While Finland seems to be a bit far up North, La Rochelle has such an advantage location. It definitely attracts a great more people from different countries, which offers me a golden opportunity to have new experience working with new colleagues like: the Swiss, German, French, Indian, Chinese, Afghan, so on and so forth.
– It would be a lost if I did not mention the great Business Game course I had at the beginning week of the semester. Basically, it is a simulation business environment working in the same universe and each team is a entire company. We have General Manager, Marketing Manager, Financial Manager, Human Resource Manager, etc. and we have to make real business decisions, prepare strategic plans, take care of projects during "8 years". After every year, there will be a report (in real life called "competitor surveys") on how each business doing and their sales and profits in order to learn from success as well as failure to make the right decisions for the coming year. Lucky and pressure enough, I was appointed as General Manager. Our business lost the most in the first few year and at the end of the game, we are the second in profits, sales and market shares! In short, it was a very exciting course that I hope JAMK will include in the future curriculum (as my friend studying business in Saimaa UAS also had this course last semester).
– I also had such a hard time with Yield Management course! In fact, most my classmates did. A lot of forecast tools and formula, and numbers and we barely had enough time to go into details with enough practices for them. There came the exam! I sweat like a pig during the exam, try to finish everything with my basic instinct! Everybody went out of the examination room with such frustration, afraid that exchange students like us would have to take re-sit exam, which will be in June 2014!! Hearing from my classmates, I checked the exam results last week and it turned out that it is the course I earned the highest grade! Some friends told me half the class scored 15 to 19 out of 20 while the rest could not make it to 5/20. Such a mysterious case!
– It seems that I found out personal interest in Marketing, Relational Marketing, Customer Service etc. When I came to college I still wonder what exactly the path for me is, eventually there is some hints for me, which I feel so happy about and cannot wait to try out for internships. Maybe after the surprise for the Yield Management, I would also want to try some for some hotel I think haha.
– Thanks to the French, I can see there are so much more to learn about the place ones live in and realize the importance of knowing the surroundings, facts, figures to look out for opportunities. In addition, I understand how ambition can lead you somewhere great thanks to a very ambitious and "hardcore professional" (who introduce herself like that rather than being a college teacher). Now I read the news everyday and thanks to that I enrich my conscious about the world really fast and effective. Awesome!
– I had a chance to make new lovely friends and awesome trip to Cognac. It is a small city renowned for tourists to visit brewery and wine making tour. We visited Martell, famous for its Cognac in France though it was such a pity that Remy Martin did not open that day.
– It captured my attention that many French has come to Vietnam for internships, and many of them have great interest in he country and culture. It is understandable that just half a century Vietnam was colonized by the French, but thanks to its, more and more French people nowadays know a lot about Vietnam, which is very interesting to share the cultures.
– Realize many the opportunity in the field of study, especially in touristic country like France- it's critical to try your best in the field with some faith! There would be a potential investment!
– The sad thing: Study from 9am til 6pm, sometimes as early as 7.30am and lasts until 8pm makes me really tired. Therefore, I have no time to participate in favorite sport – TKD – like in Finland, which makes me feel so distressed and desperate. Health going down a bit for sure.
– Good thing: Sunny almost all the time! The weather is just perfect with its moderate temperature even in winter. Awesome choice in food, cheese and obviously wine! The price of wine is lovely as well. Cannot ask for more! My studio is right at the train station so I can see everyday how many people come and leave La Rochelle, and I have to admit this is such a popular place to visit for the French people!


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Do people go through a metamorphosis?
If you have been following my journey let me share. If you haven't and are new – welcome!
Of late things are going crazy. My paper notepad is all used up and I'm on pad 2 and a voice inside my head whispers.. "
"You need folders and a filing cabinet.." This sounds extreme but I'm starting to get a glimpse why…
In earlier posts I've mentioned this year I'd like to do things that scare me.. And let me share with you since I've said that how a whole can of whoop worms are coming out..
So here's what I've done so far.. They may not seem major to you but huge milestones n millstones…
Looking at bank statements – Yep I never used to do this. Not only am I doing this I'm also starting budgeting and saving. I used to hide and fear these. Now I am better but it is a hard mindset to change
Giving blood – fear of blood and needles
Planning for the future.. Never done it.. Live for today but I'm actually thinking about planning for the future and excited about raising money to put into these pots.
Reading.. I hate it.. Find it boring -Now I'm reading blogs articles books on business creating a reading list.
Goal setting. Goal setting.. Just repeating it sends shivers of scariness yet today I'm writing myself goals, short term, long term, goals around goals and these goals make sense and it's like I actually look forward to doing these and by doing these I'll get a sense of achievement answerable only to myself.
These are all only in the last couple of weeks and I'm just getting started.
I really couldn't have done this without you readers, so thank you from the bottom of my heart.
Maybe if I get the hang of it and you need help with anything perhaps one day I can return the favor.
Grab a coffee or drink and Come follow me on my journey
Need support on your journey or move forward with your life, Are you wondering how to stop being scared or want to do something scary but…
Drop me a line – let's chat.
Peace n love


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Join Us In Guatemala
Our Guatemala retreat is for surfers of all levels, from pure beginner to advanced. We chose this destination for it's laidback spirit, consistent swell and untouched black sand beaches. We're confident you'll love the all around good vibes in Guatemala.
The Surf
Because the beaches in Guatemala face directly South, they pick up just about every swell that rolls along the Pacific and over to Guatemala. You will be surfing mostly beach breaks and river mouths with some opportunities to surf secret point breaks if the swell is right. The break works on anything from knee high to double overhead and not a day goes by where the waves are not surfable. We surf in small groups to ensure that you work closely with your coach all week and maximize your experience in and out of the water.
Yoga & Activities
Yoga is an integral part of our days at Rise Up and is scheduled to compliment the daily surf sessions. When you're not surfing or practicing yoga, you can participate in the following organized activities:
- A boat cruise through an estuary
- Take a cooking class with a local family
- Dinner out at a local restaurant
- An afternoon volunteering at a local NGO
Optional activities (not included) are a day trip to the colonial city of Antigua and extra yoga classes.
What makes this package so unique?
Not Included
- International flight to Guatemala City
- Travel Insurance
- Massages
- Photos taken by our professional photographer
- Alcoholic drinks, souvenirs and tips


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Medicolegal Issues in Obstetrics and Gynaecology pp 329-332 | Cite as
First Online:
- 376 Downloads
This is one of the commonest procedures performed in the UK. It is classed as a permanent and irreversible method of contraception. During consent alternatives to this method should be discussed in addition to the risks associated with it. This is usually performed laparoscopically by the application of Filshie clips on the isthmus of the tube. When a failure occurs there is a high risk of an ectopic pregnancy and this should be a differential diagnosis in women presenting with amenorrhoea following a sterilisation.
KeywordsSterilisation Contraception Permanent contraception Essure Hysteroscopic sterilisation
- 1.Faculty of Sexual and Reproductive Healthcare (FSRH) Clinical Effectiveness Unit guideline. Male and female sterilisation; 2014. http://www.fsrh.org/pdfs/MaleFemaleSterilisationSummary.pdf.
- 2.NICE Clinical Knowledge Summaries. Contraception – sterilisation. https://cks.nice.org.uk/contraception-sterilization#!scenario:1.
- 3.Varma R, Gupta JK. Failed sterilisation - evidence-based review and medico-legal ramifications. BJOG. 2004;111:1322–32.CrossRefGoogle Scholar
- 4.Antoun L, Smith P, Gupta JK, Clark TJ. The feasibility, safety, and effectiveness of hysteroscopic sterilization compared with laparoscopic sterilization. Am J Obstet Gynecol. 2017;217(5):570.e1–6. https://doi.org/10.1016/j.ajog.2017.07.011. pii: S0002-9378(17)30853-0.CrossRefGoogle Scholar
- 5.Mao J, Pfeifer S, Schlegel P, Sedrakyan A. Safety and efficacy of hysteroscopic sterilization compared with laparoscopic sterilization: an observational cohort study. BMJ. 2015;351:h5162.CrossRefGoogle Scholar
- 6.Perkins RB, Morgan JR, Awosogba TP, Ramanadhan S, Paasche-Orlow MK. Gynecologic Outcomes After Hysteroscopic and Laparoscopic Sterilization Procedures. Obstet Gynecol. 2016;128(4):843–52.CrossRefGoogle Scholar
- 7.Dhruva SS, Ross JS, Gariepy AM. Revisiting essure - toward safe and effective sterilization. N Engl J Med. 2015;373:e17.CrossRefGoogle Scholar
- 8.Varma R, Gupta JK. Predicting negligence in female sterilization failure using time interval to sterilization failure: analysis of 131 cases. Hum Reprod. 2007;22:2437–244.CrossRefGoogle Scholar
Copyright information
© Springer International Publishing AG, part of Springer Nature 2018


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MEXICO CITY -- Bryson DeChambeau kept making so many birdies in the Mexico Championship that when he rolled in his ninth one from 45 feet, all he could do was throw his hands in the air in pure wonder.
He wasn't alone Friday in making birdies, although Rory McIlroy would have liked to join the party.
DeChambeau made seven birdies in an eight-hole stretch at Chapultepec Golf Club for an 8-under 63, giving him a one-shot lead over Erik van Rooyen of South Africa and Patrick Reed at the halfway point of this World Golf Championship. DeChambeau was at 11-under 131.
Van Rooyen, who played college golf at Minnesota, celebrated his 30th birthday by making nine birdies to tie the course record with a 62. Reed made five birdies on the back nine for a 63.
Justin Thomas ran off four straight birdies to end the back nine, and then he holed a 35-foot eagle putt to build a three-shot lead through 10 holes. That was gone in a matter of four holes as player after player kept rolling in putts on a day with much less wind and far better scoring. The average score was 70.28, more than two shots better than Thursday.
Hideki Matsuyama was 9 under for his round through 15 holes and had a 20-footer birdie attempt from the fringe on the par-3 seventh. He missed that 3 feet to the left, then missed the next one. He bogeyed the next hole, too, and had to settle for a 64. That left him at 9-under 133, along with Thomas, who settled for a 66.
McIlroy wasn't so fortunate. Staked to a two-shot lead at the start of the day, he opened with eight straight pars, didn't make a birdie until his 12th hole and fell six shots behind at one point. Two birdies at the end gave him a 69, and the world's No. 1 player was only three shots behind.
"I made eight pars in a row, and then it's like, 'OK, you're either going to make a birdie or a bogey. What's going to come first?' And I ended up making bogey," McIlroy said. "There's a long way to go."
DeChambeau can use all the science he wants with calculations for altitude and air density. The difference for him on this day wasn't that difficult to figure out.
"I just made a lot of putts today," he said.
His big run began on the 18th hole with a 15-foot birdie putt. He got up-and-down from short of the green on the reachable par-4 first hole, made a 15-footer on the net hole, added a few birdies inside 6 feet, and then he made a 25-foot birdie. That apparently wasn't enough.
His tee shot on the 223-yard seventh hole with a green fronted by water went toward the back of the putting surface, leaving DeChambeau a downhill putt that was tough to lag. His putt was a perfect pace, and a perfect line, as it turned out.
"I just threw my hands up in the air. I mean, come on. Who thinks I'm going to make this one?" DeChambeau said. "Matt [Fitzpatrick] just looked at me and he was like, 'What are you doing? Go get a lottery ticket or something.'"
Reed seems to play his best with a chip on his shoulder, and his 63 comes after a week in which Brooks Koepka and ex-CBS broadcaster Peter Kostis brought up his rules violation in the Bahamas, stirring more bad memories.
"I'm not going to lie, just the whole thing on the outside distracts us from our ultimate goal, and that's to go out and play great golf and continue to try to improve every day on and off the golf course," Reed said. "As long as you're doing that, then you're living the right way. So at the end of the day, you can't please everybody, and I feel like I'm doing everything I need to be doing to continue to strive in the game of golf, hopefully on and off the golf course."
Most intriguing of the lot is van Rooyen, who finished the year among the top 50 to earn his first trip to the Masters.
Now it's about building a schedule on the road to Augusta. He has a sponsor exemption to the Honda Classic -- van Rooyen moved to the area last summer -- and needs to be in the top 50 each of the next two weeks to get into the Arnold Palmer Invitational and The Players Championship. He stands at No. 52.
"I think at a tournament like this and a field like this, if you can play well, you can play well anywhere," van Rooyen said. "So if I continue the way I'm going, it'll be a big confidence booster."
Defending champion Dustin Johnson continued to struggle. A two-time winner in Mexico, Johnson has made only three birdies in two days. He shot 71 on Friday and was 16 shots behind.


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dtr shares the win - May 2015Alice Buchanan May 31, 2015 : 0
dtr recently ran a national competition for under 16 rugby league teams to win a training session with the Vodafone Warriors. The battle for top spot was fierce with teams sending nearly 3000 keen voters into local dtr stores to vote for their teams.
The Manurewa U9 Marlins, Marist U12 Saints and the Papakura U8 Tui's all came so close it was heartbreaking but at the end of the day the Glenora U11 Ewoks triumphed with over 800 votes, an incredible effort.
There can only be one winner but we wanted to acknowledge the Marlins, Saints and Tui's so dtr invited them plus their coaches and parents to attend the Vodafone Warriors vs Knights home game. We presented all the kids with gear bags, drink bottles, posters and actual Vodafone Warriors mouth guards as a reminder of the day. The clubs didn't miss out either with each coach being presented with 5 dtr/Warriors branded rugby balls.
It was a great chance to meet the coaches and the kids and give these kids a day out. Unfortunately the weather was atrocious but judging by the shining eyes and smiles I don't think the kids cared! The Vodafone Warriors also turned in a very tense win as well which was the icing on a slightly damp cake for everyone!
The Glenora U11 Ewoks will be enjoying their prize in July and we will be sure to cover in detail their day so keep your eye on our blog.


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Kim Kardashian has denied rumours of an affair with Scott Disick, the husband of her sister Kourtney.
Despite branding her brother-in-law as "stylish and smooth", the 30-year-old reality star determined during an appearance on Jimmy Kimmel Live that Disick would be too much for her to handle.
She insisted: "I get why everyone thinks he's such a douchelord. But don't you think he looks so stylish and smooth? It's his personality, it goes with him. To me it's, like, stylish.
"I guess I shouldn't say this because on the cover of one of the tabloids it says Scott and I are having an affair and we are in love, or something ridiculous."
She sarcastically added: "I really wanted to confess that."
Kardashian recently described Disick as "a great guy" and thanked him for supporting her during an infamous bar confrontation last year.