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The Windmill: Not an exercise in spinal torsion, it's a simultaneous hip hinging and spine rotation. Promotes strength and flexibility of the shoulders hips and back.
- The movement is spine rotation plus hip flexion rather than spine torsion
- The back leg is straight
- Most of the weight is on the back leg
- The front knee is soft and tracks the foot
- There is no spine flexion or torsion
- The elbow stays locked, the shoulders stay packed


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Transport Wheelchair, T-2000 – 26 lbs,T-2019
The T-2000 Series by Karman Healthcare is a lightweight compact transport wheelchair with fixed full length armrests & footrest with Velcro mount leg strap. The frame folds for easy traveling and/or storage and weighs only 23 lbs with the footrest.
The breathable nylon upholstery is high-grade, flame retardant and easy to clean. With 8" rubber casters you will have a smooth ride on any surface. This transport chair offers seat width options and has a weight capacity of 250 lbs.
Product Features
•Lightweight Steel Frame
•Folding backrest for travel or storage
•Fixed armrest & footrest with velcro mount leg strap
•8″ flat free front casters
•High-grade flame retardant, breathable nylon upholstery
•Weight: Only 26 lbs with footrest
•Foldable backrests for easy storage
•Folding aluminum frame with powder coat finish in optional colors
•Frame Color: Black
•Rear caster toggle wheel locks
Product Measurements
HCPCS Code E1038*
Seat Width 17 inch., 19 inch.
Seat Depth 16 inch.
Seat Height 19 inch.
Back Height 19 inch.
Overall Height 40 inch.
Overall Open Width 22 1/2 inch., 23 1/2 inch.
Weight Without Riggings 26 lbs.
Weight Capacity 250 lbs.
Shipping Dimensions 25″ L x 32″ H x 11″ W
T-2000 – Steel Transport Wheelchair UPC#

subset: commoncrawl


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Eric OrtonAll plans by this Coach
20 Weeks
5 Run, 2 Day Off
22 miles
running marathon
This plan is protected by our Refund Policy and may, with the author's approval, be exchanged for a plan of equal value from the same author.Still have questions about this plan?
Every training plan is built specifically to use within the TrainingPeaks desktop apps, iOS app, and Android app. During purchase you will be asked to login or create a free account to start your training.
This 20-week 50K Trail Ultra Marathon training plan requires the use of a heart rate monitor. It was designed by Eric Orton, using his proven training principles developed from 21 years of coaching experience. It works well for seasoned runners and following this plan will prepare you for your race by including all of the elements used by Eric in training his personal coached ultra runners.
To start this plan you should have completed a 90 minute long run or more and have an experienced background in running, including marathons. The workouts included in most weeks alllow you to customize the plan to your capacity for weekly volume. Weekends are very specific, with a focus on "quality" back to back runs. The exception is in R&R weeks every fourth week when training is greatly reduced for 4-5 days. These R&R weeks will allow for adaptation and improved performance.
BT: WU: 20 min. at an easy to moderate effort + 5 X 30 sec. building speed. TEST: The test is best done on flat terrain or track. TEST - After your WU, run ONE mile as fast as you can. Focus on being steady and not going out too hard. CD: 5-10 minutes nice and easy.
Data RECORD: Capture your average heart rate for the one mile test and follow the directions below to create your HR training zones.
WU: 5-10 min. in zone 1 working on good mid foot strike and quick turnover. MS: Steady in zone 2 with a focus on cadence. Count how many times your right foot hits the ground in 15 second. Look to hit 23 per 15 seconds. CD: Zone 1.
WU: 5-10 min. in zone 1-2 working on quick turnover and driving knees forward. MS: Zone in zone 2 with a 10-20 second moderately hard pick-up every 8-10 min. during the run. CD: Zone 1.
WU: 20 min. in zone 1-3 + 5 X 30 sec. building speed. MS: 6 X 15 sec. steep hill repeats with 2-3 min. RI. These should be done at a strong, progressive effort. Focus on starting out fairly easy and ending hard. Go by what feels hard for you. These should not be a max effort. Train, don''t strain. This means that the focus should be on consistency. Have a goal to be consistent with all of these at the same quality. CD: Zone 1-2.
WU: 15 min. in zone 1-2. MS: Fluctuate your efforts between zone 2-3 as you feel. Avoid running steady for very long, change it up often. Great on a hilly course. CD: Zone 1.
WU: 20 min. in zone 1-2. MS: Steady in zone 3. CD: Zone 1.
WU: 5-10 min. in zone 1 working on good mid foot strike and quick turnover. MS: Steady in zone 2 with a focus on cadence. Count how many times your right foot hits the ground in 15 second. Look to hit 23 per 15 seconds. CD: Zone 1.


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We are so proud of this girl!
Tia graduated from ASU with her degree in Theraputic Recreation.
Her final semester was spent doing an internship in downtown Phoenix
at St. Joseph's Hospital in the Neuro-Rehabilitative Department.
In just a couple of weeks, Cassidy will graduate from Mountain View.
We had to get a picture of our TWO graduates...
a TORO and a SUNDEVIL!
Another project Tia has been working on...
BABY BOY ALLRED due September 16th!
Her 21 week baby bump!
Life is good!


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If you are looking for great dental care without a high price, you don't need to look any further. We offer payment plans and accept most major insurance plans to help keep your out of pocket costs low.
With a combined 22 years of experience, you can trust our dentists to handle you with the ultimate care.
Speak one on one with our dentists to ensure you get everything you need.
From cosmetic dentistry to general dentistry, we provide a wide range of dental services for your entire family.
We even welcome special need patients so everyone receives great care.


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Visual tales of NY fashion week / fall 2014 / first impressions
Some of you who know me might have heard me at least once, in the past two years, complaining about how nowadays I cannot find time to fully connect to…Read more
Some of you who know me might have heard me at least once, in the past two years, complaining about how nowadays I cannot find time to fully connect to…Read more
Saturday, January 11th What do people do, after a short vacation, when they come to the end of a week that picks up where the day of Christmas eve left…Read more
'In my childhood / teen-ish days, I remember how I had to search for' … and that's what's left of my 450 words article for this post ( damn WordPress…Read more
Milan Fashion Week always provides the most glitter & gold you can usually get for one season, and an extra dose of fully confident sex-appeal. It also sets the stakes…Read more
The color & shape exploding (well, a lot less color than usual, truth be told) fashion twirl is just about to be wrapped up and filed as 'reasons I will…Read more
In an ideal world, my ideal self would be happily, rapidly browsing through each and every collection to appear on the internet during fashion week, then jotting down ideas and…Read more
Here we go again, breathlessly zig-zagging through the latest updates of our tireless, self-reinventing muse – Fashion! In other words, the pre-fall collections are breaking through, some of which present themselves as…Read more
For me, the best months of the year are September and February, and the reason is rather easy to guess: Fashion Week! The much anticipated change in season works for…Read more


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Technology ecosystems are product platforms outlined by core components made by the platform proprietor and complemented by applications made by autonomous firms in the periphery. These ecosystems offer solutions comprising a bigger system of use than the original platform proprietor created and solve an necessary technical issues within in an industry. They perceive the geographical changes produced by the increasing use of know-how. There is additionally the problem of air pollution and the depletion of pure assets on account of processes that make the most of expertise.
The event of technology might draw upon many fields of information, including scientific, engineering, mathematical , linguistic , and historic data, to realize some sensible outcome. Complete works similar to Vitruvius' De architectura (first century BC) and Agricola's De re metallica (1556) paid much consideration to practical aspects of expertise however little to philosophy.
The predominant place of science in the philosophical sight view made it troublesome for philosophers to recognize that expertise merits special consideration for involving issues that do not emerge in science. Specifically, they use their ICT functionality to entry information; gather, analyse and symbolize information; mannequin and interpret concepts and relationships; and communicate science concepts, processes and knowledge.
Third, expertise is the information that makes the technological course of potential. This tempo of know-how and battle for codecs is racing even quicker than the development of the display devices. This does not necessarily mean that technology itself is pointed out because the direct trigger of those negative developments.
Beneath I have detailed points on the advantage and disadvantage of know-how in enterprise, classroom or training. According to Bunge, theories in expertise come in two types: substantive theories, which provide knowledge in regards to the object of motion, and operative theories, which are concerned with action itself.


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Visit my online store
We have new products for every crafter to love!
New Annual Stampin' Up!
I am so excited to share the launch of the new Annual Stampin' Up! catalog with you today. It has over 200 pages of crafting ideas and supplies and every time I look at it, I see something new that I just have to have.
Stampin' Up! is committed to providing you with the highest quality products possible. That means you've got access to tons of new products—including some favorite items from previous catalogues that have carried over for the next year.
There are 5 beautiful new In Colours being introduced, 29 new bundled products and numerous all-inclusive kits just to name a few but the list goes on a on.
As your demonstrator, I can help you earn even more rewards when you host your own stamping event.
Visit the online store to start shopping now, or Contact me for more details


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I've attended many other courses and training courses ( non-academic) trying to learn android development, technical tutorials wasn't sufficient to get me up and running , I've attended (Creative , Playful Android ) which took about 8 weeks which I believe really prepare me for this course. but this course put me on the right track , right now am able to build an application from the ground even things I didn't take in the lecture.
am very thankful for Dr.Adam and every one how helped in this course.
Thanks , and keep moving forward.


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Guest Article by Alayna Pehrson – Digital Marketing Strategist at Best Company
Millions of people are striving to build credit to enjoy the benefits of a good credit score. Building credit, however, isn't as easy as it may seem. Even if you had a solid credit education, you might still make credit mistakes if you aren't paying attention. Here are a few common credit mistakes you should be aware of.
Overspending for rewards
Credit card rewards are a good motivation to use a credit card; however, many people are so motivated that they fail to realize how much they are actually spending. Regularly using a credit card can help build your credit, but overusing the card or using the card to make large purchases can be harmful to your credit and increase your debt. Having a rewards-based card can provide you with great benefits, but be aware of your overall credit card usage.
Using store credit cards
Store credit cards can appear attractive if you are looking for discounts and other rewards. What you may not realize before signing up for a store credit card, however, is that the interest rates can be extremely high if you choose to carry a balance on the card instead of paying it off monthly. Many retail stores will do everything in their power to get you to sign up for a store credit card. Even if you think you are credit savvy, you might not be able to keep up with store credit card interest rates.
Failing to check credit reports
This mistake is more common than you may think and can definitely harm your credit score. If you don't check your credit report, then you won't know if there are any credit report errors that need to be fixed or if there has been any suspicious activity that could lead to identity theft or fraud. Although you may be afraid to face potential mistakes on your report, knowledge is more powerful than ignorance. Overall, regularly checking your credit report can help you avoid a credit disaster.
Using credit cards to pay for things you can't afford
A common myth is that credit cards are useful when you want to purchase items you can't afford. Unfortunately, this is not the case. Credit cards aren't designed for out-of-budget purchases, rather they should be treated as tools to build credit and maintain a budget. Instead of buying things you can't afford, you should be using your card for smaller, recurring expenses that you could pay with cash or a debit card. After you make a payment with a credit card, pay off that bill as soon as possible to ensure you are avoiding late payments and rising debt.
Cosigning a loan
Although you may want to help someone get approved for a loan, cosigning isn't usually the best idea for your credit. Cosigning for loans puts you into the position of being responsible for the debt itself, almost as if you are the one who is taking out the loan. Once you cosign for a loan (or even a credit card), it will appear on your credit report relatively quickly. Many people regret cosigning when they realize the amount of responsibility they have taken on. If you or the borrower can't make the payments or handle this responsibility, then that's a good sign to stay away from cosigning.
Avoiding credit completely
The very idea of credit can be frightening, especially if you have bad credit experiences or know someone who has. Avoiding credit all together may seem like a good way to avoid credit card debt or low credit scores. However, avoiding credit usually causes more harm than good. When you avoid credit, you aren't actively raising your credit score or building good credit. Instead, your credit will suffer and you won't be able to enjoy any benefits that come with good credit. Credit history is important and the longer you avoid credit, the worse your credit history looks and the more opportunities you miss. If you are scared of credit, you can do your research to figure out how to start building credit as well as find out why having good credit is so important.
Carry on the conversation on our social media platforms. Like and follow us on Facebook and leave us a tweet on Twitter.
Questions about credit repair?
Chat with an expert: 1-800-255-0263
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Dripping in Style: Modern B + W Wedding in Marfa, TX
Sweet + Simple Fall Wedding Inspiration in a Modern Warehouse Venue
Texas Forever: Elegant Country Wedding Inspiration in Whitesboro
The Ultimate Bohemian Wedding at a Greenhouse
This Couple Brought all the Moody + Sexy Vibes to their Warehouse Wedding
Australian Design Meets Southern Hospitality: The Grace Loves Lace Showroom Comes to Dallas!
Bring the Boho Home: Their Backyard Wedding was Inspired by Marfa
Married in Marfa! A Bold, Art-Inspired West Texas Wedding
This Wedding Has All the Starry Out-of-this-World Design Details You'd Ever Want!
This Little White Chapel is Brimming with Bohemian-Inspired Southwestern Charm!
5 Tips to Throw the Ultimate Fall Dinner Party!
She Surprised Her Husband with the Wedding They Never Had…Seven Years Later!
How to Plan the Ultimate Trip to Marfa, Texas
Sunset in Texas: A Southwestern-Inspired Elopement with a Bit of Latin American Flair
Be Still Our Bohemian Hearts—It's an Ombre-Filled Coachella-Inspired Festival Wedding!
A Black + White Vogue-Inspired Bridal 'Lingerie' Shower… with Dalmatian Puppies!
Moody Wildflower Wedding in the Heart of Texas
Rain Didn't Stop this Industrial Meets California-Inspired Wedding in Texas
These Two Had a Colorful Smoke Bomb Exit for Their Wedding — And It Was AMAZING!
Pampas Grass, Patterned Rugs + Donkeys: An Eclectic Garden Party Wedding Inspired by Travels
Texas Goes Boho with Rich Hues for this Inspired Wedding
Rustic + Rad: Intimate Vow Renewal in the Desert of Marfa, Texas
Fun-Fueled Modern Wedding with Pops of Red + Balloons Galore
email email@example.com to advertise with gws


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The importance of influenza viruses as worldwide pathogens in humans, domestic animals, and poultry is well recognized. Discerning how influenza viruses interact with the host at a cellular level is crucial for a better understanding of viral pathogenesis. Influenza viruses induce apoptosis through mechanisms involving the interplay of cellular and viral factors that may depend on the cell type. However, it is unclear which viral genes induce apoptosis. In these studies, we show that the expression of the nonstructural (NS) gene of influenza A virus is sufficient to induce apoptosis in MDCK and HeLa cells. Further studies showed that the multimerization domain of the NS1 protein but not the effector domain is required for apoptosis. However, this mutation is not sufficient to inhibit apoptosis using whole virus.
Apoptosis is essential in many physiological processes, including tissue atrophy, development of the immune system, and tumor biology (19, 21, 28, 73). Apoptosis also plays an important role in the pathogenesis of many infectious diseases, including those caused by viruses (4, 27,46, 48). Many virus infections result in apoptosis of host cells, and several viruses have evolved mechanisms to inhibit apoptosis (52, 62). Although there is no obvious advantage for the induction of apoptosis by a cytopathogenic virus, influenza viruses induce apoptosis in numerous cell types both in vivo (29) and in vitro (6, 18, 24, 30, 39, 49, 50, 57).
Influenza viruses induce apoptosis in cells that are permissive for virus replication like macrophages, Madin-Darby Canine Kidney (MDCK) and mink lung epithelial (Mv1Lu) cells (18, 24, 30, 37), and cells which do not support viral replication, such as HeLa cells or lymphocytes. The mechanism of influenza virus-induced apoptosis is not known in detail. However, it appears to involve both cellular and viral factors and may depend on the cell type. Influenza virus-induced apoptosis is inhibited by bcl-2 (37), v-FLIP, and crmA (59) and involves caspase activation (59). There is also evidence for indirect activation of apoptosis during infection. In HeLa cells, Fas antigen, a transmembrane protein belonging to the tumor necrosis factor receptor superfamily (36), and the Fas ligand are upregulated during influenza virus infection and are partially responsible for apoptosis in infected cells (10, 54-56, 67). Through these studies, we have a better understanding of which cellular pathways may be involved in influenza virus-induced apoptosis. However, it is still unclear which viral genes induce apoptosis in cells that support productive viral replication.
It is possible that the expression of any of the individual influenza virus genes may induce apoptosis in the infected cell. The neuraminidase protein (NA) appears to induce apoptosis through indirect and direct mechanisms. Indirectly, NA activates transforming growth factor β (TGF-β) in vivo and in vitro (49). TGF-β is a multifunctional growth-regulatory protein that induces apoptosis in many cell types, including lymphocytes (23) and MDCK cells (45, 49). Neutralizing antibodies against TGF-β only partially inhibit influenza virus-induced apoptosis, suggesting that NA can also induce apoptosis directly. These findings were further supported by Morris et al. (30), who showed that NA induces apoptosis in different cell lines by a TGF-β-independent, virus-dependent mechanism.
In MDCK cells, apoptosis occurs early in the course of viral replication (18). Therefore, it is likely that viral genes expressed early in replication and that interfere with normal cellular processes or associate with cell proteins involved in apoptosis may induce apoptosis directly. In these studies, we focused on the role of the nonstructural (NS) gene.
The NS gene is the smallest segment of the influenza A virus genome and is transcribed into a colinear mRNA encoding two proteins, NS1 and NS2 (also called NEP) (22, 38). Unlike NEP, NS1 is found only in infected cells. NS1 regulates numerous cellular functions during influenza virus infection by binding to polyadenylated mRNAs, inhibiting nuclear export (3, 16, 26, 40, 43); binding to small nuclear RNAs (snRNA), specifically to key components of the spliceosome, blocking pre-mRNA splicing (2, 8, 25, 44, 69) and inhibiting the polyadenylation of host cell mRNA (31); and interacting with several host cell proteins (26, 31, 71,72). The RNA-binding activities of NS1 are based on the interaction of two functional domains: an RNA-binding domain at the amino end of the protein (amino acids 19 to 38) that binds to poly(A) sequences in mRNAs (43), and an effector domain (amino acids 134 to 161) that interacts with cellular proteins to inhibit mRNA nuclear export (40). These domains are highly conserved within the NS1 gene (20, 68), suggesting that NS1 is evolutionarily conserved.
Arguably, one of NS1's most important functions is inhibiting the activation of the double-stranded RNA (dsRNA) kinase (PKR), thus preventing the interferon (IFN)-mediated antiviral response (11,12, 17, 26). Takizawa et al. showed that a mutation in the catalytic domain of PKR partially suppresses influenza virus-induced cell death (58). Based on the ability of NS1 to interfere with host cell RNA functions and block the activation of PKR, we propose that NS1 is involved in influenza virus-induced apoptosis. These studies show that expression of NS1 in different cell types is sufficient to induce cell death. Further, using NS1 mutants, we show that the RNA-binding/dimerization domain but not the effector domain is required for NS1-induced apoptosis in cell culture.
Virus growth and cell culture.A/Turkey/Ontario/7732/66 (A/Ty/Ont/66) (H5N9; University of Wisconsin influenza virus repository) was propagated in the allantoic cavities of 10- or 11-day old embryonated chicken eggs for 48 h at 35°C. The allantoic fluid was harvested, centrifuged for clarification, and stored at −70°C.
MDCK and HeLa cells were grown in modified Eagle's medium (MEM; Life Technologies, Gaithersburg, Md.) supplemented with 10% fetal bovine serum (FBS; Life Technologies) and 2 mM glutamine. All cells were maintained at 37°C in 5% CO2.
Construction of plasmids.Full-length NS gene from A/Ty/Ont/66 was PCR amplified, ligated into the TA vector (Invitrogen, Carlsbad, Calif.), and then subcloned into the expression plasmid pUHD 10-3 (kindly provided by Hermann Bujard) at the EcoRI site. Expression vector pUHD 10-3 contains the heptamerized tetracycline repressor gene operators upstream of the cytomegalovirus promoter in two different orientation sites (15, 47, 51). Clones were screened for proper orientation by restriction enzyme digestion and sequence analysis.
All of the A/Udorn/72 NS1 genes described in this paper were expressed using an NS1 gene containing a 3′ splice site mutation (NS13′SS) ligated into the pBC12 vector via the BamHI site as described previously (2, 40, 68, 70). All mutations were confirmed by dideoxynucleotide sequencing. The cDNAs of NS13′SS (NS1), NS13′SS DM (no NS1 produced), NS1 M2 mutant (R19 and K20 changed to A [RK 19/20 AA]) and NS1Δ117-161 (Table1) were cloned into the BamHI site of pUHD 10-3. Plasmids were transformed into Escherichia coli DH5α competent cells (Life Technologies), amplified, and purified using a Qiagen (Valencia, Calif.) purification kit.
Reassortant virus.Two viruses containing a mutation in the NS1 RNA-binding domain (RK 19/20 AA or RK 19/20 AD) were constructed in an A/WSN/33 backbone by reverse genetics as described elsewhere (33, 34). Parental WSN and mutant viruses were propagated in MDCK cells grown in MEM containing 5% bovine serum albumin (BSA) and 1 μg of l-1-p-tosylamino-2-phenylethyl chloromethyl ketone–trypsin (Sigma Immunochemicals, St. Louis, Mo.) per ml. Viral titers were determined by 50% tissue culture infective dose.
Stable expression system.The pUHD 10-3 expression plasmid containing full-length NS, NS1, and NS1 mutants and the transcriptional transactivator (pUHD 15-1) expression plasmid containing the tetracycline repressor gene fused with the viral VP16 coding sequence containing the neomycin cassette (kindly provided by Wen-Hwa Lee) (51) were electroporated into MDCK or HeLa cells. Briefly, cells were electroporated with 10 μg of DNA of both plasmids, and G418-resistant cell lines expressing the protein of interest were selected. The cell lines were maintained in MEM containing 10% FBS in the presence of 2.5 μg of anhydrotetracycline per ml (14) and 400 μg of G418 per ml. Incubating the cells in tetracycline-free medium induced expression of the full-length or mutant NS gene.
DNA fragmentation assay.Fragmentation of cellular DNA into the characteristic apoptotic ladder was assessed as previously described (49), with minor modifications. Briefly, confluent monolayers of cells expressing pUHD 10-3 expression vector, NS gene, or NS1 mutants were washed with phosphate-buffered saline (PBS) and incubated for various times in tetracycline-free MEM containing 1% FBS. Prior to processing of the DNA, cell monolayers were trypsinized and cell numbers were determined. DNA was harvested by centrifuging the cells, resuspending the cell pellet in 300 μl of cold cell lysis buffer (10 mM Tris, 0.5% Triton X-100 [pH 7.5]), and incubating it on ice for 30 min. The lysates were centrifuged at 12,500 rpm for 10 min at 4°C, and the supernatants were extracted once with buffered phenol and once with chloroform. The DNA was precipitated with 300 mM NaCl and ethanol. DNA samples were resuspended in 15 μl of Tris-EDTA buffer (10 mM Tris, 1 mM EDTA [pH 7.5]) treated with RNase A (Life Technologies). Equal cell numbers were loaded and electrophoresed through a 2% SeaKem GTG agarose gel FMC Bioproducts, Rockland, Maine). The gel was stained with ethidium bromide to visualize DNA fragmentation. Cell viability was also assessed by trypan blue exclusion. Uninfected cells and cells infected with A/Ty/Ont/66 collected at identical times served as controls.
Western blot analysis.Infected or DNA-transfected cell monolayers were lysed, and total protein concentration was determined by the bicinchoninic acid assay (Pierce, Rockford, Ill.). Equal protein concentrations were heated for 3 min at 100°C in sample buffer containing β-mercaptoethanol and resolved by sodium dodecyl sulfate–5 to 20% gradient polyacrylamide gel electrophoresis (SDS-PAGE). After transfer to nitrocellulose, the proteins were blocked with 1% powdered milk in Tris-buffered saline with 0.1% Tween 20 (TTBS; Sigma Immunochemicals) for 30 min at room temperature. The nitrocellulose was probed for NS protein expression using mouse monoclonal or rabbit polyclonal antibodies diluted 1:1,000 in TTBS and incubated for 1 h at room temperature. Proteins were detected by incubation with a secondary antibody conjugated to horseradish peroxidase followed by enhanced chemiluminescence (Amersham, Arlington Heights, Ill.) according to the manufacturer's protocols.
Expression of NS proteins induces apoptosis.Previous studies showed that HeLa cells undergo apoptosis during influenza virus infection. To determine if the expression of NS1 and NS2 was sufficient to induce apoptosis, HeLa cells were transfected with the full-length NS gene from A/Ty/Ont/66 in a tetracycline-regulated system, and cells expressing NS proteins were selected and screened for protein expression by Western blot analysis. NS protein expression was evident 24 h after tetracycline withdrawal and increased slightly at 48 h. NS protein levels in the NS-expressing cells were much lower than levels in infected cells (Fig. 1A). In spite of low protein levels, DNA fragmentation was observed in NS-expressing cells within 8 h after the removal of tetracycline (Fig. 1B). DNA fragmentation was not observed in HeLa cells in the presence of tetracycline.
Similar studies were performed with MDCK cells. MDCK cells were transfected with the full-length NS gene from A/Ty/Ont/66 in a tetracycline-regulated system, and two clones (NS D1 and NS D5) expressing NS proteins were selected. Similar to the case for HeLa cells, the levels of NS protein were much lower in all clones tested than in infected cells (Fig. 2A). In spite of low protein levels, NS D1 and NS D5 were tested for DNA fragmentation after the removal of tetracycline. Increased fragmentation was observed in both NS D1 and NS D5 in a time-dependent manner (Fig. 2B). DNA fragmentation was observed as early as 5 h after the removal of tetracycline in clone D1; however, clone D5 had slower kinetics, and laddering was not evident until 24 h after tetracycline removal (Fig. 2B). No DNA fragmentation was observed in MDCK cells expressing only vector after the removal of tetracycline. Similar results were observed in mink lung epithelial and chicken embryo fibroblast (CEF) cells (data not shown). These results show that NS induces apoptosis in different cell types regardless of their ability to support productive viral replication.
NS1 induces apoptosis.The NS gene of influenza virus encodes two proteins, NS1 and NEP (NS2). Attempts to express NEP in the tetracycline system were unsuccessful. Therefore, we examined the induction of DNA laddering in two different MDCK clones expressing NS1. Similar to expression of the NS proteins, NS1 expression induced DNA laddering in a time-dependent manner (Fig.3A). Both clones (NS1 C4 and NS1 C9) showed clear apoptosis 24 h after the removal of tetracycline, with more intense laddering observed at 48 h. The expression of NS1 protein is required for apoptosis in this system. Two cellular clones expressing an NS1 splice site mutation containing two stop sites (E8 and G4), which makes no NS1 protein, failed to induce DNA laddering after tetracycline withdrawal (Fig. 3B). No fragmentation was observed in the MDCK cells expressing vector alone. Similar to the NS protein analysis, the clones expressing NS1 had significantly less NS1 protein than did infected cells.
The effector domain of NS1 is not required for apoptosis.NS1 has a number of described functional domains, including an RNA-binding/dimerization domain and an effector domain that interacts with cellular proteins (3, 25, 26, 32, 40-44, 53, 68). To determine if either of these domains is required for the induction of apoptosis, MDCK cells expressing NS1 proteins with a mutation in the functional RNA-binding domain/dimerization (amino acids 19 and 20 mutated from RK to AA [M2]) or a deletion of the effector domain (amino acids 117 to 161) were tested for DNA fragmentation. The deletion of the effector domain had no effect on DNA laddering (Fig.3B). Fragmentation was observed at 5 h and then increased through 48 h, similar to clones expressing full-length NS1. In contrast, a mutation in the RNA-binding/dimerization functional domain resulted in no DNA fragmentation even at 48 h after tetracycline removal (Fig.3B). This result could be explained by the loss of NS1 protein expression in cells expressing the RNA-binding/dimerization domain. However, Western blot analysis shows that this clone was expressing NS1 protein within 5 h after removal of tetracycline and that protein levels were still detectable at 48 h (Fig. 3C). These studies show that expression of the NS1 protein is sufficient to induce apoptosis in numerous cell types by a mechanism that is independent of the effector domain.
Reassortant WSN virus containing a mutation in the NS1 RNA-binding domain induces apoptosis.The generation of the plasmid-based reverse genetics system provides a powerful opportunity to understand the importance of single gene mutations within the context of whole virus (33, 34). Based on the results described above, the RNA-binding/dimerization region of the NS1 protein is required for NS-induced apoptosis in MDCK cells. To determine if this mutation is sufficient to delete influenza virus-induced apoptosis, we attempted to generate viruses whose NS1 proteins have mutations that abolish RNA-binding/dimerization activity. Two different mutations were generated, RK 19/20 AA and RK 19/20 AD. Both of the mutant viruses were infectious, although they were highly attenuated in MDCK cells compared to parental WSN virus, averaging a 3-log-lower virus titer. To determine if the mutant viruses could induce apoptosis in MDCK cells, cells were infected with a multiplicity of infection (MOI) of 2 and examined for DNA laddering at 24 and 48 h postinfection (p.i.). A high MOI was used to ensure maximum levels of apoptosis independent of replication differences between the parental strain and the mutant viruses. At 24 h p.i., the RK 19/20 AA mutant virus induced laddering similar to that observed with WSN virus (Fig.4). In contrast, no laddering was observed at 24 hr p.i. with the RK 19/20 AD virus; however, both viruses induced apoptosis by 48 h, similar to the WSN parental virus. Similar results were seen in mink lung epithelial and CEF cells. These results suggest that while the RNA-binding/dimerization domain is required for NS1-induced apoptosis, a mutation in this region is not sufficient to inhibit influenza virus-induced apoptosis.
The above results show that the expression of the NS1 protein of influenza virus in MDCK and HeLa cells is sufficient to induce apoptosis. Western blot analysis showed that very little NS1 protein was expressed in the NS clones compared to influenza virus-infected cells. MDCK cells are difficult to transfect, and even after electroporation, only 1 to 10% of the surviving cells expressed NS. Additionally, the NS1 protein proved to be very toxic to MDCK cells. We were unable to generate stable cell lines expressing NS1 protein even under the control of the tetracycline-regulated system. The system was slightly leaky even in the presence of high concentrations of anhydrotetracycline, a stable tetracycline derivative. During selection of clones, cells expressing high concentrations of NS died; therefore, the G418 selection time was shortened from 2 weeks to 1 week to allow analysis of NS-expressing clones. Attempts were also made to express NS1 in MDCK cells by using the ecdysone system, with similar results (data not shown). Similar problems were observed in mink lung epithelial and CEF cells but not HeLa cells. It is unclear why the HeLa cells were better able to support expression of the NS protein.
Further studies using well-described NS mutants showed that the RNA-binding domain, but not the effector domain, is essential for the induction of apoptosis. Previous studies showed that mutating amino acids R19 and K20 to alanine resulted in a loss of dsRNA binding and U6 snRNA binding (32). More recently, Wang et al. showed that R19 is essential for dimerization of the NS1 protein (70). These results suggest that RNA binding and/or dimerization of NS1 protein may be required for the induction of apoptosis by NS. The mutation of the effector domain would have no effect on dimerization or RNA binding. In support of these findings, a laboratory variant of A/Turkey/Oregon/71 virus, which encodes an NS1 protein that is only 125 amino acids long and lacks an effector domain (35), also induces apoptosis (data not shown).
Using a WSN backbone, influenza viruses containing mutations in the RNA-binding domain of the NS1 protein were generated and examined for apoptosis. The growth of the mutated viruses was highly attenuated compared to the WSN parental strain in MDCK cells (data not shown). However, the mutated and parental viruses grew to equal titers in Vero cells and CEF cells prepared from 6-day-old embryos (unpublished data). Similar results were shown with viruses containing long deletions in the NS1 protein or lacking the NS1 gene entirely (5, 12,17). These results suggest that mutating the RNA-binding/dimerization region of NS1 protein may inhibit NS1's ability to inhibit PKR activation and IFN response. Despite attenuation in MDCK cells, the mutated viruses induced apoptosis similarly to parental WSN virus when used at an MOI of 2. In addition, apoptosis was inhibited with caspase inhibitors (59), suggesting that the viruses used similar cellular pathways leading to cell death.
The induction of apoptosis in the NS1 mutant viruses may also be due to the activation of the IFN-induced PKR and IFN (10, 54-56, 58,67). During virus infection, PKR is activated by its interaction with dsRNA, resulting in a cascade of effects including activation of transcriptional factors leading to apoptosis (13). NS1 inhibits the activation of PKR through upregulation of a cellular PKR inhibitor (61), by binding directly to PKR (17), and by inhibiting IFN regulatory factor 3 (60). Takizawa et al. showed that PKR is involved in influenza virus-induced apoptosis (55, 58). The NS1 mutant viruses may be unable to inhibit PKR activation by dsRNA, leading to PKR autophosphorylation and increased IFN levels, resulting in cell death. Studies examining this hypothesis are under way. In the vector system, no dsRNA should be generated and PKR should remain inactive. However, it is possible that dsRNA is generated by the plasmid, and IFN levels may be elevated, resulting in apoptosis. Studies are under way to determine how expressed NS1 is inducing apoptosis and what cellular factors are involved.
We and others showed that NA induces apoptosis directly (30) and through the activation of TGF-β (49). It is probable that a portion of the apoptosis observed with the NS mutant viruses is due to NA, whether directly or through TGF-β activation. Finally, the expression of other viral proteins may induce apoptosis. During the NS studies, we also expressed the matrix (M) and nucleoprotein (NP) genes of A/Ty/Ont/66. Expression of the M gene in the tetracycline-regulated system had no effect on cell viability, and it was possible to make a stable cell line expressing M proteins. In contrast, NP also induced apoptosis in MDCK cells, although with different kinetics than NS1 (data not shown).
The question still remains as to whether virus-induced apoptosis is advantageous for viral spread or is advantageous to the host by possibly reducing viral titers. Depletion of lymphocytes in chickens infected with the highly virulent avian influenza Ty/Ont virus (18, 65, 66) and mice infected with the highly virulent human A/Hong Kong/483/97 virus (64) is associated with apoptosis. It has been suggested that influenza virus-induced apoptosis of lymphocytes may be important in viral pathogenesis in highly pathogenic influenza virus. In addition, cells undergoing influenza virus-induced apoptosis are taken up by dendritic cells, inducing a cytotoxic T-cell response (1). Similarly, macrophages phagocytose infected cells through an apoptosis-dependent mechanism (9). These results suggest that understanding the role of apoptosis in influenza virus pathogenesis will be complex and may be dependent on the cell type and environment. However, these studies will increase our understanding of viral pathogenesis and may lead to new therapies for influenza virus infection.
We are very appreciative to Robert Krug (University of Texas at Austin) for providing the NS1 and NS2 constructs used in these studies, for providing technical assistance in establishing the cell lines, and for critically reading and revising the manuscript. We are also grateful to Martha McGregor and Laura Kelley for expert technical assistance, to Hermann Bujard (University of Heidelberg) for the tetracycline-responsive system, to Robert Webster (St. Jude's Children's Hospital) for the monoclonal antibodies against NS proteins, and to Chris Olsen, Diane Larsen, Matthew Koci, Holly Sellers, and Terry Tumpey for critically reading and revising the manuscript.
This work was supported by Public Health Service research grants from the National Institute of Allergy and Infectious Diseases to V.S.H. and Y.K. S.S-C. was supported initially by a postdoctoral training fellowship in tumor virology through the McArdle Cancer Center at the University of Wisconsin followed by USDA CRIS project 661232000020.
- Received 2 April 2001.
- Accepted 24 May 2001.
↵* Corresponding author. Mailing address: Southeast Poultry Research Laboratory, USDA-ARS, 934 College Station Rd., Athens, GA 30605. Phone: (706) 546-3464. Fax: (706) 546-3161. E-mail:sschultz{at}seprl.usda.gov.
- Copyright © 2001 American Society for Microbiology


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Furnace Maintenance in Baltimore, Lutherville-Timonium, Ellicott City, MD and the Surrounding Areas
Furnace Maintenance Services in Baltimore, Lutherville-Timonium, Ellicott City, Columbia, Glen Burnie, Bowie, Towson, Dundalk, Catonsville, Laurel, Woodlawn, Nottingham, Randallstown, Abington, Essex, MD and Surrounding Areas.
Furnace maintenance in Baltimore, Lutherville-Timonium, Ellicott City, MD and the surrounding areas is a task that needs to be on your to-do list every single year. Your furnace's safe operation means more than just low bills and a warm house. It also means your family's well-being. Also, SuperTech HVAC Services provides affordable furnace maintenance options. So here is all you need to know!
Heater Maintenance Steps You Can Take
Furnace maintenance can be dealt with both by you and by the professionals. This means that there are some simpler tasks which you can take on your own. But there are also complicated procedures that require an HVAC professional to come to your house. Calling in a pro will save you a lot of time and effort.
What You Can Do
- Check the air filters every 30 days to make sure they are clean.
- Replace the batteries in your CO and smoke detectors every year or as often as it is needed.
- Test your CO and smoke detectors to make sure they are working properly.
- Seal all the air leaks in your house. Don't forget about the attic! If you have any air leaks, they will make your furnace work a lot harder than it should.
Call a Professional
- If you see any rust or soot around the furnace, leave it to a professional to deal with it.
- Should you notice that the furnace's flame is not blue, it may be a sign that the system is contaminated with debris and needs a deep cleaning. Call an HVAC Technician!
- Furnace maintenance should be performed once a year to make sure it's in top shape and safe to use. Reach out to your trusted expert at the beginning of each heating season to check everything for you!
Request An Estimate Today!


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MidAtlantic and Summit Drilling install deep ground water monitoring wells using sonic drilling technology in a complicated geologic system at this former urban industrial facility that is a … [Read More...]
Recent Projects
MidAtlantic Environmental Services Team Works to Install Monitoring Wells at Residential Redevelopment
Redevelopment at Fort Monmouth Now Preparing for First Wave of Homeowners
MidAtlantic Engineering was engaged for civil engineering, surveying, and permitting services in the effort to preserve and reuse the historic Officer's and Non-Commissioned Officer's Quarters at Fort … [Read More...]
MidAtlantic Provides Engineering and Dive Services for Glimmer Glass Bridge Rehab
MidAtlantic provided full time on-site Resident Engineer Dive Services during the course of construction for the timber pile rehabilitation of the approaches of the Historic Glimmer Glass Bridge. … [Read More...]
MidAtlantic Provides Services for Historic Restoration of Hartley Dodge Building
MidAtlantic Engineering was engaged for civil engineering services and surveying in support of exterior renovations to the historic Hartley Dodge Memorial building in Madison, NJ. MidAtlantic worked … [Read More...]
MidAtlantic's Waterfront Services Team Provide Dive Inspection Services to Aid in Site Rehabilitation
MidAtlantic's engineer divers are on-site today performing a design level inspection of a mooring dolphin to ascertain the dimension and quantify the exact repair areas to aid in the rehabilitation … [Read More...]
MidAtlantic Works with Thomas Edison State College and Design Team on New School of Nursing
MidAtlantic Engineering worked successfully with the school and design team providing civil engineering, surveying, and permitting services in support of the 28,000 SF School of Nursing Building, … [Read More...]


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The Big Five Oh!
50 years ago today, about 1:30 in the afternoon, Jan and I exchanged vows, rings and "I Do's" in a little chapel on Northington Campus, the married student's housing at the University of Alabama in Tuscaloosa, AL.
I was wearing a suit and my beautiful red-headed wife was wearing a wedding dress that she had made herself the week before.
Along the way we had two great kids, Christopher Andrew and Brandi Leigh, and two fantastic grandkids, Piper Jean and Landon Thomas.
Jan later said she was determined for us to stay together for at least the first five years just to spite my mother.
I made the Clear Lake run again this morning, with a quick segue to get a haircut (quick because it doesn't take long.) before getting to the office.
I did make a lot of progress today, finally getting into the tattoo shopping cart and resetting the passwords, so that means I can now update prices and make corrections.
I also made a big leap ahead on hacking into the Linux webserver, finally getting access to the Linux desktop on the machine. So now I can see where I need to get to, and to do that I need to get 'root' access to the system.
That will let me get into the mail server and add and update email addresses. In addition, it will help me get further along on moving the Zen Cart shopping carts to an off-site server, along with the mail server.
So now I've got to start going through all the possible passwords I've gleaned from scattered text files and scraps of paper laying around. But as of yesterday, I'm completely on my own as far as the password situation goes, with no possible additional input from the previous IT guy, as he died in the nursing home yesterday.
Although I only met him a few times, I was sorry to hear that.
The Word of the Day is: 'Tittle'
Thought for the Day:
"Nothing in all the world is more dangerous than sincere ignorance and conscientious stupidity." – Martin Luther King, Jr.
19 Responses to The Big Five Oh!
Happy Anniversary! I would love to Jan dress so please share pictures.
Jan and Greg….Happy 50th Anniversary. Lois is correct, pictures would be great. Karen made her dress 43 yrs ago, I wore a powder blue tux, that was big then, we walked down the isle together, and my Dad married us. It was different but her father had passed away 9 yrs earlier. After the 25th, her sister-in-law asked what we were going to do, Karen said we would give it another year.
Well that is special 50th I mean, not the PC hacking!
You both have some tales to tell.
HAPPY ANNIVERSARY guys!
Happy Anniversary you two with many more to follow.
Thought for the day could be applied to today's world leaders.
Be Safe and Enjoy!
It's about time.
I remember seeing photos in the neespapers of couples celebrating their 50th anniversary and they all looked so stiff, angry, sad, old and miserable. But look at you two!!! You are both young looking, active, engaged and living a lifestyle most would be envious to persue. Happy anniversary!
Happy Anniversary it only gets better.
Happy Anniversary Jan and Greg
Happy Anniversary to both you kids! ♥ Have a fun-filled day and a great dinner…
HAPPY ANNIVERSARY! You both look like you got lots more to go. Loved the comment about Jan and the "rub" with the mother-in-law. Did she ever come around?
Happy 50th Anniversary!
Happy Anniversary. Hope you have many more happy years together.
Happy Anniversary Jan & Greg! I cannot imagine a happier union, except maybe a lower case "j" and its tittle. LOL
Thought we shared the same anniversary date – 27th. However, ours is #65, When did we get so old. And we are still RVing on a limited basis. Started with pop-ups back in 1964!! Wishing you and Jan many more happy, healthy years together!!
Happy anniversary to you both.


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Help! I need to look my best, FAST!
So you have an event. You probably should have started prepping a while back but life got in the way and now it's go time. Beauty 911! What can you do over the next few months, even days, to make the biggest difference in your skin and show up at your event as the Belle of the Ball?
Check out the following minimally invasive options that require little or no downtime:
a.Benefits: Smooth, wrinkle-free skin and/or higher arched eyebrows (if requested).
b.When to start: Ideally begin six months prior, and repeat as recommended. Otherwise 3 weeks before will give you a boost just in the nick of time!
2. BT – HydroFacial
a.Benefits: Detoxified and rejuvenated skin, resulting in a smoother appearance.
b.When to start: Can be done up to the day before the event.
3. Latisse Eyelash Treatment
a.Benefits: Doubled eyelash fullness. Darker, thicker lashes.
b.When to start: Four months before the event.
4. Xtreme Eyelash Extensions
a. Incredible lashes within 2-3 hours!
b. Can be done the day before or even the morning of the big event
5. Fillers
a. Bring back the fullness to cheeks, hollow eye troughs, around the mouth, lips, even the temples can be given a little 'plump' youthfulness
b. To be done 4-6 weeks before the event.
6. Regular Facial Treatments
a.Benefits: Clearer, smoother, more even skin.
b.When to start: Ideally 6 months before event but even the day before can plump and smooth enough to give you a Red Carpet look!.
7. Detox/Ultimate Reset 21 Day plan
a.Benefits: Detoxes rid the body of toxins, clears skin, improves energy and can also aid weight loss, to help you achieve a slimmer look for the big day.
b.When to start: At least 21 days before your big day.
Now….go, Cinderella!
Botox, Mayfaire Towne Center


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news +
January 9, 2020
Welcome the new talent at WINTER HOLBEN
Weʻre thrilled to announce some new additions to the team at Winter Holben! Kelsey Wise has joined us as a Senior Experience Designer. Kelsey studied design and illustration at Maine College of Art and is a native to the seacoast region.
December 18, 2019
Foresight is 2020
The course of our business changed over the course of 2019.
November 15, 2019
Sponsoring Pecha Kucha
Pecha Kucha, which is the Japanese word for chit chat, is a storytelling platform where individuals present 20 images, with 20 seconds of commentary per slide.
September 3, 2019
WINTER HOLBEN wins Best of the Seacoast
With over 300,000 votes tallied for this year's Best of the Seacoast awards, WINTER HOLBEN was honored to be chosen as the as the 2019 First Place Winner for Best Architecture and Design Firm.
August 2, 2019
Take the WINTER HOLBEN brewery tour
It's August on the Seacoast, which means the garage doors are open, the umbrellas are out, and it's the perfect time for a brewery tour.
June 14, 2019
Point of No Return - Sponsoring TEDx
Attending last year's TEDx Portsmouth event[news/Top-takeaways-tedx-portsmouth/] at the Music Hall had us walking away inspired and engaged in our community and our work at WINTER HOLBEN. As a result, there was no hesitation for us to return as 2019 sponsors.
May 15, 2019
WINTER HOLBEN architecture + design Awarded for Excellence in Architecture
Merit Award winners recognized for their innovative approach to contemporary design KITTERY, ME, May 15, 2019 — WINTER HOLBEN was recently honored at the 2019 Excellence in Architecture Design Awards with the Unbuilt Architecture Merit Award in recognition of the team's Islington Station Remix, an innovative redesign that transforms an abandoned...
April 26, 2019
WINTER HOLBEN engaged to create the vision plan and expansion opportunities for Albacore Park
Originally formed as the Bring Back Albacore committee, the Portsmouth Submarine Memorial Association, custodians of the USS Albacore, are thinking about the future.
March 29, 2019
Islington Station Remix receives 2019 AIANH Excellence in Design Merit Award
WINTER HOLBEN recently received a 2019 Merit Award for their Islington Street Remix Design at the 35th Annual AIANH Excellence in Design Awards.
February 28, 2019
Designing an exterior touchscreen window pilot for Bank of America
The first locations of an exciting new exterior touchscreen application put forth by Bank of America were recently installed in Boston, MA and Washington D. C.
January 15, 2019
WINTER HOLBEN designs hotel, mixed-use development
WINTER HOLBEN architecture + design was recently engaged by property owners to complete a feasibility study and preliminary design for an exciting 117-room hotel and mixed use development in nearby Newburyport, Massachusetts.
December 1, 2018
Parker Street Mixed Use Development Unanimously Approved by Newburyport Zoning Board
79 Parker Street is currently an underutilized historic farm site located within Newburyport's Business and Industrial Park. Over the past few years, the identity of the industrial park has evolved from almost all manufacturing to the home of more diverse destinations like breweries, restaurants, and workplaces.
October 26, 2018
Elisa speaks about her Authentic Design Life at CreativeMornings
CreativeMornings is a global lecture series for the creative community that is brought to our seacoast region as Creative Mornings PKX by some very dedicated and talented local volunteers.
September 24, 2018
Our Top 3 Takeaways From TEDx Portsmouth
This year TEDx Portsmouth (formally known as TEDx PiscataquaRiver) upped its game.
August 31, 2018
Good Design is Good Business
Reflections on the 2 Year Anniversary of Great Rhythm.
June 1, 2018
Creating space for innovative learning
How can we create an educational space that allows students and teachers to explore unconventional curriculum? This was the question posed to WINTER HOLBEN by TRAIP Academy's leadership team.
May 2, 2018
Coming This Summer: York Beach Beer Co.
Just in time for your summer plans, construction has begun on the York Beach Beer Co. in York, ME.
March 12, 2018
The Press Room Third Floor Expansion Approved By Portsmouth HDC as Renovations Continue
Legendary Portsmouth hot spot, The Press Room, is about to get a much needed update - and we are thrilled to be designing and coordinating the renovation and expansion.
February 15, 2018
Sponsoring Our Local 'PechaKucha Night' Series
From gallery openings to local lectures, we're always looking for new ways to connect to our community and bring that inspiration back to our work.
February 13, 2018
WINTER HOLBEN Wins AIANH Excellence in Architecture Award for Islington Multi-family Streetscape
Winter Holben architecture + design of Kittery, Maine, received a 2018 AIANH Excellence in Architecture Award for its Islington Street multi-family streetscape project PORTSMOUTH, NH, February 2, 2018 — WINTER HOLBEN architecture + design of Kittery, Maine, announced the selection of its Islington Street multi-family streetscape project for a 2018 AIANH...
January 30, 2018
Planning the Transformation of a Railyard into a Vibrant Neighborhood Development
On January 30th WINTER HOLBEN, along with the project team, hosted a neighborhood meeting at Great Rhythm Brewing Co. to share the vision for transforming the adjacent railyard property into a vibrant neighborhood.
December 6, 2017
The Wilder, an Exciting Addition to the Local Restaurant Scene
Anju and the Wallingford Dram happen to be two of our favorite culinary establishments in Kittery so needless to say we were thrilled when owners Michael Pazdon and Julian Armstrong asked us to design the renovation for latest endeavor, The Wilder.
December 6, 2017
Designing The "Making Space" Donor Wall for 3S Artspace
We love designing donor recognition walls not only because they acknowledge the generosity of those who make our arts, cultural, and educational destinations possible, but because they can tell a story about the organization and improve the visitor experience.
November 19, 2017
Bank of America Architectural Feature Celebrates Boston
WINTER HOLBEN architecture + design recently unveiled a large custom sculptural installation at Bank of America's 100 Federal Street Boston headquarters.
September 26, 2017
Sharing Our Design Approach at AIANH's Archtoberfest
In the fall, we hosted the AIANH's annual Archtoberfest along with Scott Thornton, owner of Great Rhythm Brewing Company.
September 20, 2017
WINTER HOLBEN Wins Excellence in Architecture Award for Great Rhythm Brewing Co.
Landmark project in Portsmouth, NH — a growing hub of the New England beer community — is celebrated by AIANH, as the two year-old firm completes four brewery projects in the past year, and begins work on a fifth KITTERY, ME, September 20, 2017 — WINTER HOLBEN architecture + design, a...
September 12, 2017
Celebrating 25 Years Of Ocean Education
To commemorate the Seacoast Science Center's 25th birthday and Wendy Lull's 25 years of leadership, WINTER HOLBEN donated the design of "School of Fish". The playful installation consists of translucent fish (each carrying a donors name) that "swim" along the lobby windows along aluminum waves.
February 26, 2017
Husband, wife combine skills in WINTER HOLBEN architecture + design
Wife and husband team combine their skills to create WINTER HOLBEN architecture + design, located at 7 Wallingford Square in Kittery, Maine's Foreside. KITTERY, ME, February 26, 2017 — Brandon Holben and Elisa Winter are husband and wife.


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New York Sharks Off to 3-0 Start on Season
The New York Sharks are off to a 3-0 start on the season. They have been close and competitive games, but the Sharks have continued to find ways to pull off victories.
Jaws of Steel
In their first game against a very talented Baltimore Nighthawks team, they scored the game-winning touchdown with 7:10 left in the game. The defense was able to hold the Nighthawks scoreless for the final seven minutes of the game.
They showed that they can overcome adversity in their second game against the Philly Phantomz. After falling down 13-0 in the first quarter, they were able to outscore the Phantomz 21-6 in the remainder of the first half.
The two teams went back and forth in the second half, but the Sharks would prevail. They defeated the Phantomz by a final score of 28-25 to improve to 2-0.
After a Week 3 bye, the Sharks held their home opener against the Baltimore Nighthawks, who they defeated to open the season. After two close contests, the Sharks played dominant football. They jumped out to a 35-0 lead, 35-7 at halftime, and never looked back
New York went on to win by a final score of 49-26. The 23-point win is their largest win of the season thus far. They will be looking to advance to 4-0 next Saturday when they travel to take on the Maine Mayhem.
The Sharks are looking to bounce back in 2018 after falling in the second round of the 2017 Women's Football Alliance (WFA) Playoffs to the Montreal Blitz. IF they can continue their stellar performance, they could see themselves back in the postseason.
Round 1 of the 2018 WFA playoffs will be played the weekend of June 30. The second and third rounds will be played the weekends of July 14 and July 21. The 2018 Women's Football Alliance championship game will be played on Saturday, July 28 in Atlanta, GA.
Stephen Ur
Latest posts by Stephen Ur (see all)
- Darnold is the issue with Jets, not Gase - November 13, 2019
- Jersey Flight Join National Arena League for 2020 Season - October 25, 2019
- Jersey Flight: 2019 Season in Review - June 11, 2019
- New York Jets Defeated by Miami Dolphins, 20-12 - September 16, 2018
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The Catholic University of America's four-year, 120-credit-hour undergraduate program in city and regional studies is an interdisciplinary, non-professional degree program leading to the Bachelor of Science in City and Regional Studies (B.S.C.R.S.). It prepares students to understand the complex issues that impact the human environment by addressing social, political, economic, environmental, and physical forces. Students develop skills to explore and evaluate not only the physical patterns of cities and their surrounding regions (i.e., the buildings, street networks, open spaces, etc.), but also gain a more holistic insight into the complex challenges of contemporary urban life. They will better understand diverse populations and the forces that impact development.
Students pursue knowledge in a range of disciplines, develop significant writing skills, qualitative and quantitative analytical skills, and gain the capacity to think critically about urbanized places and their stakeholders. Armed with this knowledge graduates can better advocate for social equity and justice in communities in the United States or abroad. Coupled with a minor in sustainability, history, sociology, or politics, the graduate of this program could envision new and innovative alternatives to community challenges thereby improving quality of life. They might work at the scale of the individual or the region in public, private, or non-governmental organizations that focus on community or economic development as well as public policy, public administration, and law, among other areas. A person with the B.S.C.R.S. degree might pursue graduate work in city planning, law, sustainability, social work, and public policy or administration.


text: The island country of The Bahamas is a popular destination for beach vacations in the Caribbean. It is home to the top rated Caribbean beaches. From developed family-friendly beaches to secluded spots ideal for romantic escapades, there are beaches to match every temperament. For adventure sport enthusiasts, there are ample facilities for diverse water sports in the popular beach areas of the Bahamas. To help visitors to the scenic Caribbean Island find the beach of their choice, the website caribbeanlogue.com has compiled a list of the best beaches in Bahamas. The resorts overlooking the beaches are the perfect places for indulging in luxury. As Bahamas attracts all types of visitors, accommodations catering to different budgets are easily available in the beach areas.


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Our best selling bags. With enough confetti for one person in each they're a perfect choice.
They can be presented in crates or pop them with the order of service on each chair before the ceremony.
Bags are sent out with enough petals and sticker(s). We don't want your bags bursting in transit. We'll always try to make up at least one to show you how they should look.
When your pink parcel arrives pop in a call to your Bridesmaids, any excuse to have a girls night – Grab a bottle, some grub and pack your wedding confetti.
Packs can be made up on request at a cost of £1.00 each.


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NYC offers an endless list of attractions for visitors to enjoy, so a few days won't suffice. The best way to get the most out of New York sightseeing is to narrow your focus to a few major tourist spots in New York's five boroughs. There are distinct sites and attractions in each of the five boroughs you won't want to miss. Get ready to experience the excitement that awaits you right here in the Big Apple!
Here's a list of main tourist attractions in each of the five boroughs:
The Bronx
The innermost NYC borough of the Bronx is full of historical landmarks and sights. The late 18th century Bronx Zoo is perhaps one of the most popular attractions and home to some 5,000 species of animals. Sports fans can't miss visiting Yankee Stadium–the Mecca of baseball. The New York Botanical Garden, The Lillian and Amy Goldman Stone Mill, Enid A. Haupt Conservatory and Rockefeller Fountain are a few infamous sites. No trip would be complete without a visit to famed Arthur Avenue, the heart of Little Italy, where old-world Italian delicacies abound. Once you've had your fill of cannolis and cappuccinos, take a stroll through the beautiful campus at Fordham University.
NYC Map Photo Gallery
Begin at iconic Central Park and explore 843 acres of serene gardens filled with rich history. Stand in the middle of Grand Central Station or Penn Station to get the feel of rush hour commuter traffic. See Time's Square lit up at night and take in a Broadway show. Pay a visit to Lady Liberty and Ellis Island's Immigration Museum. Experience famous works of art up close and personal at the Solomon R. Guggenheim Museum and Metropolitan Museum of Art. Don't forget to catch the New York Public Library's free exhibits!
Queens is home to vast Flushing Meadows Corona Park, the famed site of two World's Fairs. You will want to check out the Queens Museum, the Queens Zoo, and the Queens Botanical Gardens. Make sure to include the Museum of the Moving Image and the contemporary wing of the Museum of Modern Art (MoMA PS1), both located in hip Long Island City, also home to Gantry State Park and Long Island City Flea and Food-an open air market with a giant array of food and booths.
Drive, bike or walk the mile-long 18th century Brooklyn Bridge, which connects Brooklyn with Manhattan, and capture unforgettable views of Manhattan's skyline. Ride the legendary Cyclone Rollercoaster at famed beachfront Coney Island, or just stroll the boardwalk and try a famous Nathan's hot dog. Check out hipster habitat, McCarren Park, and in the summer take a dip in its 1500-person capacity pool. Lose yourself in NYC's second largest museum, the Brooklyn Art Museum, and its neighboring Brooklyn Botanic Gardens.
Staten Island
Catch the Staten Island Ferry from Whitehall Terminal, once on board you'll see postcard-perfect views of New York City's skyline and The Statue of Liberty. Staten Island is the greenest borough with some 12,300 acres of parkland and don't miss its newest attraction, the New York Wheel, a 630-foot wheel, which will open shortly. Staten Island Zoo and Staten Island Children's Museum are great fun for the entire family. Don't miss the Snug Harbor Cultural Central, which includes six exciting attractions at one location.
Maybe You Like Them Too
- Beverly Hills Hotel, LOS ANGELES
- Palace Of Versailles Kingdom Of The Sun King
- Rio de Janeiro Help Disco
- Rio de Janeiro


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Scientists from Trinity have taken a giant stride towards solving a riddle that would provide the world with entirely renewable, clean energy from which water would be the only waste product... Read more
A team at Lehigh is the first to use a single enzyme biomineralization process to create a solar-driven water splitting catalyst that produces hydrogen with the potential to be manufactured... Read more
A cheap and effective new catalyst developed by researchers at the University of California, Berkeley, can generate hydrogen fuel from water just as efficiently as platinum, currently the be... Read more
A photoelectrode has been developed that converts light energy 11 times more efficiently than previous methods
Scientists have developed a photoelectrode that can harvest 85 percent of visible light in a 30 nanometers-thin semiconductor layer between gold layers, converting light energy 11 times more... Read more
Solar-powered water splitting is a promising means of generating clean and storable energy. A novel catalyst based on semiconductor nanoparticles has now been shown to facilitate all the rea... Read more
Rutgers study opens door to broader use of sunlight and advanced materials to combat climate change Star-shaped gold nanoparticles, coated with a semiconductor, can produce hydrogen from wat... Read more
Catalyst Uses Inexpensive Elements and Could Be Scaled Up for Commercial Use Researchers from the University of Houston and the California Institute of Technology have reported an inexpensiv... Read more
The quest to develop the 'Holy Grail' of affordable, viable and environmentally-friendly fuels using sunlight has taken an exciting new twist. A team of Renewable Energy experts from the Uni... Read more
2-in-1 device also uses supercapacitor to store energy that could power computers and smartphones UCLA researchers have designed a device that can use solar energy to inexpensively and effic... Read more
A new way to produce hydrogen from water uses no expensive metals and absorbs a wider range of sunlight
Hydrogen is the most abundant element in the universe, and is considered by many to be a potential clean fuel of the future. Water and fossil fuels contain large amounts of hydrogen, but unl... Read more
It's possible to produce hydrogen to power fuel cells by extracting the gas from seawater, but the electricity required to do it makes the process costly. UCF researcher Yang Yang has come u... Read more
New Molybdenum-Coated Catalyst Produces Hydrogen More Efficiently Hydrogen is one of the most promising clean fuels for use in cars, houses and portable generators. When produced from water... Read more


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Edward Ruskin was the Reverend in Beckindale from 1960 until 1975.
Edward Ruskin was born in 1919. Edward became a vicar and later married Liz Ruskin. Liz had 3 miscarriages, plus they had a stillborn son. In 1960, Edward was transferred to Beckindale as the parish vicar.
Edward Ruskin wanted Amos Brearly to employ Alison Gibbons as a barmaid at The Woolpack. Amos was reluctant but later agreed. Ruskin often was called to help over village matters. Ruskin pumped Annie Sugden for info about the death of the wife of Charlie Nelson, a destitute elderly villager. In 1974, Ruskin clashed with local churchwarden Wally Lumm when Wally saw Ruskin at a Catholic church in Hotten.
In May 1975, Edward was asked to take over as vicar of a nearby parish and left Beckindale that month. For the next 2 years, the village had a few temporary vicars to replace Ruskin until Donald Hinton took over permanently in late 1977.
In 1983, Edward was temporarily posted back to Beckindale when Donald Hinton was away. He let his dog loose on a field and was berated by Joe Sugden until Joe recognised him and was delighted to see him again. Ruskin helped Seth Armstrong overcome his marriage difficulties with his wife Meg Armstrong. Edward then left the village for the last time.
Notable dialogueEdit
"Well it's alright, I'm not a ghost and I'm human enough to get thirsty meself, though I daresay not as often as most of you. Hello Mr Brearly, how's business?" (first line)


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Only my love of life and my granddaughters could equal my love of education and working with students. I received my M.A. in Education through Regis University, and also hold a valid Colorado Professional Teacher License in the areas of Early Childhood Education, Secondary Social Studies, and Special Education- moderate needs. For the past 18 years, I was employed as a special needs educator at the high school level and taught Pre-algebra and Algebra 1 through individualized instruction, and... ... More
I graduated with a BSc from the internationally renowned University of Auckland in March. I am continuing education here in the States, ultimately to earn my doctorate.
My best science subjects were within the medical sciences, especially anatomy and physiology. I am solid in biology.
I rounded out with several arts courses, though mostly anthropology and philosophy. I'm a writer and have tutored English students; in fact, prior to going into the sciences I began my student career as ... ... More
Sections of ACT questions relate to environmental factors. My background/degrees are in Biology, Environmental science, Life Science and botany, which comes in very handy for the ACT. A number of my previous jobs have been in these fields, gaining years of hands-on knowledge that I now use to explain to students for their better understanding of events/situations. ... More
I have been creating art for 25 years. I am a Colorado licensed art teacher and I have been actively teaching high school art for the last 5 years; I am also a working freelance artist. I hold a Bachelor's degree in Fine Arts and Illustration from Marywood University; so needless to say, I have a lot of book knowledge about art, art history, studio techniques, and art philosophy. If you desire to learn more about art, or the techniques used to create art, look no further. I can tutor ea... ... More
Hi I am a Colorado Certified teacher that has many years teaching elementary age students in public schools. I took some time off to raise my four children and have returned back to the field of education. Two years ago I took a 40 hour class in Orton Gillingham which taught a very prescribed specific way to teach phonics. Orton Gillingham approach focuses on helping kids with dyslexia. I was excited to learn this method so that I could effectively help those struggling readers where tr... ... More
I am an experienced teacher of English and ESL as well as a Spanish tutor. My love of language and my experiences as both teacher and student give me insight into the process of learning. I have a Masters of Education in Curriculum and Instruction and bilingual certification at the elementary level. I've taught and tutored English from kindergarten to junior college level, and directed an English language school in Spain. I've coached TOEFL preparation, composition and reading comprehensi... ... More


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Clifford Burgoni wanted to sell his system for cleaning 86,000 solar panels, so he made a cool drone video of the gear in operation. Read the rest
Clifford Burgoni wanted to sell his system for cleaning 86,000 solar panels, so he made a cool drone video of the gear in operation. Read the rest
Britain went a full day without using coal to generate power, reports the BBC. It's the first 24-hour period of inactivity there since 1882, when the world's first public coal-fired power plant was stoked at Holborn Viaduct in London.
But Ms O'Hara says that while the country makes the transition to a low carbon system, coal remains an important source of energy. According to Gridwatch.co.uk, around half of British energy on Friday came from natural gas, with about a quarter coming from nuclear plants. Wind, biomass, and imported energy were also used.
As in the U.S., coal power's been squeezed out by natural gas, a cleaner fossil fuel, though the trend is now toward renewable sources. Britain will close its coal-fired power plants down for good in 2025, supposedly. Read the rest
Heather videoed this charming collection of solar-powered bobbleheads. Read the rest
Aeroacoustics expert Nigel Peake of Cambridge University leads a group of engineers mimicking owl wing feathers to reduce noise on wind turbines. Read the rest
The land speed record for a regular bus has been shat on. "Bus Hound," powered by biomethane derived from cow manure, clocked 76.785mph in speed trials in England.
Operated by Reading Buses, the vehicle was painted black and white in honor of the Frisian cows whose excrement powers its mighty engines. It was designed to advance the "power and credibility of buses fuelled by cow poo," reports the BBC.
"Most importantly we wanted to get the image of bus transport away from being dirty, smelly, and slow," Chief engineer John Bickerton told them ."We're modern, fast, and at the cutting edge of innovation."
Ars Technica's Sebastian Anthony writes that biomethane is a promising technology, far greener than natural gas, but close in performance: "not only are you leaving those fossil fuels in the ground, you're also combusting methane that would've otherwise ended up as an atmospheric greenhouse gas."
If you're wondering, the answer is yes: Britain has also invented a bus powered by human excrement.
GENeco general manager Mohammed Saddiq said: "Gas-powered vehicles have an important role to play in improving air quality in UK cities but the Bio-Bus goes further than that and is actually powered by people living in the local area, including quite possibly those on the bus itself."
One human's annual output would would fuel the Bio-Bus for 37 miles. And if you're all out, there's always chip fat. Read the rest
California may be the first US state to generate more than 5% of its electricity from utility solar, but runner-up North Carolina leads the four east coast states that comprised last year's top solar states. The top ten: Read the rest
IKEA has now started selling solar panels in the UK. According the Associated Press, "a standard, all-black 3.36 kilowatt system for a semi-detached home will cost 5,700 British pounds ($9,200) and will include an in-store consultation and design service as well as installation, maintenance and energy monitoring service." Feel free to suggest funny faux-Swedish product names in the comments. Read the rest
Producing power from the wind and sun isn't as simple as just swapping a wind turbine for a coal-fired power plant. Every source of power we use has to work with our electrical grid, an old, imperfect, complex system that wasn't put together with the needs of renewables in mind. For instance, because renewable generation is intermittent generation, using it goes hand-in-hand with ramping production from traditional generation up and down. When you don't have enough wind, you turn up the gas-fire generators. That kind of treatment can put stress on machinery and rack up costs in maintenance and repairs. But new research from the National Renewable Energy Laboratory suggests that, at least in monetary terms, those costs are dwarfed by the cost savings you get from using more wind and solar power and, thus, not having to pay for fuel sources. Read the rest
How much do you know about energy subsidies? National Geographic has a really interesting quiz that covers some of the basics, as well as a few interesting background details. Here's one freebie: The first fossil fuel subsidy in America was instituted by George Washington. It was a 10% tariff on imported coal, aimed at making American coal competitive in comparison to British coal. (Via Matt McDermott) Read the rest
The Watt? is an interactive energy primer aimed at making the complicated and completely non-intuitive world of energy use a bit more understandable to laypeople.
I wholeheartedly support any effort to make this stuff make more sense. In the course of researching my book, Before the Lights Go Out, I stumbled across tons of extremely important information that was basic "duh" knowledge to energy experts—but not to you, me, and everybody actually doing the decision making on energy issues.
I ended up focusing on the story of the electric grid, how it works today, and where it might be headed in the future. But there's no way I could cover everything. The Watt? promises to fill in some of those gaps—fleshing out the details on everything from physics and terminology, to economics and technology. There will be some really lovely-looking charts and graphics, guest "speakers" embedded into the e-book, and lots of other cool surprises.
The team behind this is trying to raise funds now through Kickstarter. Their deadline is in 18 hours. If you want to better understand energy systems (or you want to help other Americans better understand them) I suggest making a donation.
If you only have the vaguest notion of what a "smart grid" actually is, don't feel bad. This is one of those energy buzzwords that confuses a lot of people. Part of the problem is that utility companies don't often do a very good job of communicating this stuff. They tell you it's good. They say something hand-wavey about the Internet. And then they pretty much leave you to fend for yourself.
The other part of the problem: "Smart grid" is one word that refers to more than one thing. A smart grid is actually lots of different technologies. They're related. But they do different jobs in different ways, and even one tool might have different levels of functionality that apply to it. That fact is really clear when you visit a smart grid research laboratory, as I did earlier this week at the Colorado State University.
The school's Engines and Energy Conversion Laboratory houses a little micro-grid, where electricity can be generated, used, and stored in ways that model the workings of the real-life grid. The smart grid technologies the laboratory is used to study apply to every part of that system—smart grid is part of generation, it's part of how electricity is moved around, it's part of how we consume electricity, and it's part of how we balance supply and demand and avoid blackouts. In other words: This seemingly vague and esoteric concept is actually closely tied to practical, day-to-day realities.
Yesterday, I got to go on NPR's Marketplace Tech Report to talk about two smart grid technologies that you're likely to get some hands-on experience with in the near future. Read the rest


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Joseph T. Prete Esq.
Location: St. George, Utah
Phone: 435-628-1711
Fax: 435-628-3318
Email Me
Joseph was born in Kingston, Ontario, Canada. After serving a mission in Russia for the Church of Jesus Christ of Latter-day Saints, he attended BYU on scholarship. In August of 2002, he graduated from BYU with a bachelor's degree in international studies and a 3.8 GPA. Days later, Joseph started law school at BYU. In April, 2005, he graduated from BYU law school in the top third of his class.
While attending BYU law school, Joseph externed for the Chief Justice of the Utah Supreme Court, the Office of General Counsel for the LDS Church, and the Utah Attorney General's Office. He also served as a Senior Editor for BYU's Education Law Journal, co-authored multiple chapters for a student law/religion manual, and helped plan and orchestrate annual international law and religion symposia.
Between 2005 and 2015, Joseph practiced law in Las Vegas as a civil litigator. His primary areas of practice include estate planning, business law, litigation and real estate law.
While working in Las Vegas was a wonderful experience, Joseph and his wife, Haylee (Stout), yearned to move to Southern Utah, where they could raise their children closer to Haylee's family. Toward that end, while working full-time, Joseph took and passed the Utah bar exam in 2014. In July, 2015, Joseph joined Barney McKenna & Olmstead, P.C.
Joseph and his wife, Haylee, were married in St. George in March, 2001, and they are proud parents of seven children (five girls, followed by two boys). Joseph enjoys hiking, volleyball, piano, singing, oral history, and community service. He also enjoys languages and is conversant in Russian and French.
Areas of Practice
- Estate Planning
- Business Law
- Real Estate Law
- Estate Administration
- Civil Litigation
- Bankruptcy
- Probate
- Trust Administration
Brigham Young University, J. Reuben Clark Law School,
Provo, Utah
Law Journal: Education Law Journal, Senior Editor, 2003 - 2004
Brigham Young University,
Provo, Utah
Major: International Studies
Bar Admissions
Nevada, 2005
U.S. District Court District of Nevada
Utah, 2014
Professional Associations and Memberships
Nevada State Bar Association, Member, 2005 - Present
Clark County Bar Association, Member, 2005 - Present
American Bar Association, Member, 2005 - Present
Utah State Bar Association, Member, 2014 - Present
Southern Utah Bar Association, Member, 2015 - Present
Hurricane Valley Chamber of Commerce, Board of Directors
Honors and Awards
AV® Preeminent™ peer-review rating by Martindale-Hubbell
Past Employment Positions
Utah Supreme Court, Chief Justice, Extern
Office of General Counsel for the LDS Church, Extern
Utah Attorney General's Office, Extern
Smith Larsen & Wixom, Attorney, 2008 - 2015


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At Sheely's, we have been proactive by taking precautions for the health and safety of our employees, customers, vendors, and our community. On 3/17/2020, we self-imposed temporary closure due to the rapid spread of COVID-19.
Effective Monday, 3/23/2020 we will be closed through 4/30/2020 following Governor DeWine and Dr. Acton's Stay at Home Order.
None of this is easy and we appreciate your support and understanding at a difficult time for us all.
We look forward to seeing you, our employees, our customers, our vendors, and our community soon.
Please stay home, stay safe and God bless you all.
Pricing Info: Manufacturer online pricing restrictions
and ever changing selection makes it unfeasible
to list all prices. Contact us and we'll be happy
to give you a price on this item.
Toll Free: 877.549.9144
Bring comfort and style to your living space with this transitional sofa. It features tapered wood feet, decorative throw pillows, and nailhead trim for a tasteful design. Plus, this piece can be customized just for you, so you know you'll love it.
The 2877 Transitional Sofa with Nailhead Trim by Decor-Rest at Sheely's Furniture & Appliance in the Ohio, Youngstown, Cleveland, Pittsburgh, Pennsylvania area. Product availability may vary. Contact us for the most current availability on this product.
Give yourself the gift of high quality style with this living room collection. These seating pieces are made in Canada with care, featuring durable construction materials and techniques. They're the pinnacle of comfort too, ensuring you and your friends and family are always happy to hang out in your home.
The 2877 collection is a great option if you are looking for Transitional furniture in the Ohio, Youngstown, Cleveland, Pittsburgh, Pennsylvania area.
Browse other items in the 2877 collection from Sheely's Furniture & Appliance in the Ohio, Youngstown, Cleveland, Pittsburgh, Pennsylvania area.
This item has been tagged as: Sofa, Couch, Couches, Backless Sofas, Conversation Sofas, Conversational Sofas, Theater Seating, Theatre Seating, Home Theater Furniture, Angled Sofa, Davenport, Stationary Sofa, Stationary Couch, Home Theater Seating, Upholstered Sofa, Upholstered Furniture, Sofa Couch, Living Room Furniture, Furniture, Seating
Nothing on this page may be copied or reproduced without explicit permission.


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Country Babies Born in 2012: Hudson Lennon Jones
Eli Young Band member Jon Jones helped his wife deliver Hudson Lennon Jones naturally on Dec. 31. It was a week after the due date, but Jones tells People they were still able to stick to their birth plan. Mother and child are happy and healthy, but Jones had to miss a EYB show for just the second time ever. "They are truly great friends for letting Sarah and I share this wonderful experience together," he said of his band. "We were home within four hours of the birth to celebrate New Year's Eve as a family -- mostly holding Hudson in amazement." He'll soon be back on the road, eventually joining Kenny Chesney on the No Shoes Nation Tour in March.


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With nerdiness, duh.
The first weekend of December is quite possibly my favourite non-'Doctor Who's on' weekend of the year, which means putting up Christmas decorations (I do find it strange that my favourite weekend involves tedious manual labour and tinsel)! I saw these lovely tree decorations at the 50th Convention last weekend, so how could I not pick them up, right?
Time And Relative Decorations In Space!
I may have also built some Christmas lego to put on my desk:
I may have also built it whilst donned in a santa hat. The spirit of Christmas is strong with this one!
Anyone else got some nerdy Christmas stuff that was put out this weekend?


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Archive for July 2018
Barbecues in parks
As this very hot weather continues, we would urge people not to barbecue in Finsbury Park. London Fire Brigade has asked all boroughs to spread the message not to BBQ in parks due to a real risk of grass fires in this heat. Please follow the fire brigade's tips on preventing grass fires: Do not…Read More
Wireless Licence Review: How to make a representation – UPDATE
We have just received some more advice and clarification on some key points regarding licence review representations, from the Haringey Licensing Authority: All four licensing objectives are in consideration. The determination of the review will be based only on the four licensing objectives. Residents representations are not limited to the year specified by the FofFP…Read More


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This week's news: 11-15 January 2016Published on 15th January 2016 2016-01-15T11:57:03+00:00 - Last update on 15th December 2019 2019-12-15T00:06:41+00:00
The biggest stories this week
The biggest news for us this week was being shortlisted for two upcoming awards: the FSTech Awards, for FinTech Startup of the Year, and the Financial Director's Business Finance Awards, for Software Product of the Year. We're very proud of the work we've put in over the past few years – highlights include creating the first comprehensive map of the UK business finance market with Imperial College London, working with leading accountancy services provider 2020 Innovation, and our soon-to-be-announced progress with King's College London as we further fine-tune our matching algorithm – and we've got our fingers crossed for the ceremonies in March.
ICAEW critiqued HMRC for poor service, stating that taxpayers will have better luck writing a letter than making a phone call if they want a response to a question. As the Telegraph writes:
The news has emerged just days after Lin Homer, the chief executive of HMRC who is due to be questioned by MPs later on Wednesday, was given a damehood and said she was leaving in April with a £2.2million pension pot.
The MPs' questions didn't take this record lightly – see the Telegraph's full report here.
The World Economic Forum begins a few weeks from now, and fintech will be a big feature in the discussions. Innovate Finance writes that the forum will particularly focus on technological change in the financial sector as "the onset of the fourth industrial revolution"
The fourth revolution is envisioned to provide a change in the velocity, scope and impact technology will have on income inequality, informal economies and payment systems for billions across the globe. This is a daily reality for members of Innovate Finance who are providing solutions to the unbanked and underbanked and redefining the ways in which customers interact with money.
Tech City News gives us 6 reasons no one will fund your startup. It's good advice, but don't despair, founders – you've got a lot more options for business finance than angel investors.
More news from the fintech front: Britain's fintech regulator, Bob Ferguson of the FCA, warns that "innovation is not a licence to cut corners" and that regulation standards will be upheld. As Chris Toy pointed out on Twitter, though, just as technology adapts to regulation, regulation must adapt to technology.
The tax implications of peer-to-peer lending – where many investors lend small amounts of money to a business through an online platform – have been clarified by HMRC. In a nutshell, the investor, not the platform, will pay the tax bill. FT Adviser has the full story.
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Our goal is very simple - to help businesses find the right type of finance as quickly, transparently and painlessly as possible.Find Funding


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Defense Date
Document Type
Degree Name
Master of Fine Arts
First Advisor
Christiana Lafazani
Davida Rochlin said, "Nobody thought much about the front porch when most Americans had them and used them. The great American front porch was just there, open and sociable, an unassigned part of the house that belonged to everyone and no one, a place for family and friends to pass the time." The landscape in which those porches existed has changed. Our traditional views of housing and neighborhoods (single family homes with a cul-de-sac at the end) really aren't the norm anymore. In the last 10 years more Americans have moved to, and are living in cities than in the past (Lamber, Lisa 2012). Currently, 80.7% of Americans live in urban areas, up 1.7% from 2000 (Lamber, Lisa 2012). With this migration, there has been a surge in renovated, multi-family housing. While this does solve the problem of allowing more families to move back into urban areas, these buildings often have no sense of community or neighborhood. You don't have neighbors, you simply live next to people. The porch used to be a symbol of community, a sociable space. Neighbors would sit outside and watch kids play and catch up with each other. But both technology and our own self-imposed isolations have lead us to slowly loose touch with our physical neighbors. The intention of this project is to create a community, a neighborhood, within a single building housing multiple families through porches and their variations.
© The Author
Is Part Of
VCU University Archives
Is Part Of
VCU Theses and Dissertations
Date of Submission
May 2013


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Fixarim Detailing Extras
Air-Conditioning Anti-Bacterial Treatment
Overtime, your air conditioning system can start to fill with unwanted debris and smells. This can cause a number of health related issues if not cleaned out and deodorised. In just 30 minutes Fixarim can completely remove bad smells/embedded cigarette smells and completely clean your air-conditioning tunnels.
Cost: $75 +gst
Time: 20-30 minutes (Time dependent on size of vehicle)
Interior Spot Clean
Spilt a drink? Pet hair buildup? Nasty stains? Interior Spot cleaning is the way to go! Fixarim's Expert Detailing Technicians have you covered and will do everything possible to remove those tough marks in your interior.
Cost: $50 +gst
(Cost can increase depending on size of area)
Interior Detail
In need of an interior freshen up? Our Fixarim Detailing Technicians will make sure your interior is looking A1 and protected with the best products in the business. What's included? We will, vacuum your carpets, seats, mats, boot & parcel shelf, wipe over interior plastics and vinyls, mirrors and interior glass cleaned, rubbish thrown, food & drink fallout cleaned and fabrics deodorised.
Cost: $75 +gst
(30% surcharge for larger vehicles, ie, SUV's, 4×4's etc.)


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LUNA ECLIPSE; Cat print/poster
This variant is currently sold out
LUNA ECLIPSE Cat print
If I was an animal I would be a cat, what would you be? At Doodlemoo we absolutely love Cats, elegant, cool, independent creatures. We designed Luna Eclipse cat print inspired by our RussianBlue Miro. Puuuuurrrrrfect for the cat lovers and any room in the playful home.
Available in 5 different sizes
LUNA ECLIPSE art print is a Giclee print, printed on conservation 300gsm paper.
Mailed in a sturdy tube for protection.
(frame not included) They fit on Ikea frames or standard size frames.