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When you think of Menorca, you probably fit into one of three categories:
1 - You've never heard of it. (Don't you mean Majorca?)
2 - You've heard of it but never considered going.
3 - You've been to Menorca - and can't wait to go back again.
Whether it's tried to or not, Menorca's done a great job of keeping a relatively low profile as a holiday destination. While it's hard to find someone who hasn't heard of Majorca or Ibiza - true story: Ibiza is so well-known that my Jordanian friend thought it was a COUNTRY - saying you went to Menorca is often met with a blank stare.
Menorca is the overlooked island, the shy little sister to two of Europe's biggest party islands. And it also happens to be the Mediterranean's best kept secret. But don't overlook it just yet, because there's a surprising feast of places to explore and things to do in Menorca.
Menorca's a pretty unusual place to visit. The island is largely untouched and undeveloped, waiting to be discovered, yet already has so much to offer for the few who decide to explore.
It's a contrast that gives Menorca an irresistible charm and an air of nonchalance, like the quietly cool friend you secretly wanted to be. If Menorca were a person, you'd almost certainly like her and want to be her friend - but she wouldn't care if you didn't.
The island's not such a secret among older generations, it seems. One of the first things we noticed was that everyone seemed to be older than our group - by about 40 years or so. It surprised me at first, but it really shouldn't have: Menorca is the kind of place where there really is something for everyone, from the mother and daughter who have been visiting the same part of the island since 1981 to the adventure bloggers and twenty-somethings like me.
It has good food, beautiful views and a long list of sights to see, but what really caught me off guard me was the number of things to do in Menorca. So, here are some of the most surprising ones. Do any of them surprise you too?
1 - Kayak into darkness
Menorca's a strange place. Given how tranquil the island is, you wouldn't expect it to be a great destination for watersports and adventure. But you might be surprised: it turns out there are many things to in Menorca if you like to stay active, with hiking, boat trips, horse riding, snorkelling and diving all available.
My favourite Menorca day trip of the week has to be kayaking. It's the part I was looking forward to the most, but was SO much more fun than I expected. And that wasn't just because of the hilarious group of people I went out with...
We went out on a 3-hour tour around Cala Galdana, where the sea is the postcard-perfect colour you picture when you think of faraway islands and exotic. With 26-degree heat beating down as we took it all in, it was hard to believe we were still in Europe.
The best part, however, was paddling into "dragon's cave" - after my friend Emily and I initially started paddling into the wrong cave, oops! - with only head torches to see where we were going. Once inside, we all switched our lights off and sat in complete darkness. It was one of those special moments you know you'll remember forever and it was the moment my eyes were opened to just how magical Menorca can be.
2 - Sip cava in a cave
Menorca may be the non-party island, but that doesn't mean it doesn't have its own nightlife. In fact, it has a bar like no other: Cova d'en Xoroi.
If you've ever fancied sipping cava in a cave, Cova d'en Xoroi is the place to do it. Trek down a few flights of steps that look like they're leading you straight to Santorini and you'll find the entrance tunnel at the bottom. Enter through the tunnels and you'll find a bar built into the side of the cliffs, with areas to sit and mingle along the cliff face, inside the caves and everywhere in-between. And yes, it's every bit as cool as it sounds.
Did I mention that it has perfect views of the sunset?
3 - Explore the island in an electric car
Much of Menorca is still undeveloped. On the one hand, that means it's safe from the touch of non-stop tourism, but it also means it's not the easiest place to get around. Many of the best sights and views are hard to reach, so it's worth hiring a car for at least a day to explore some of the island's hidden spots - they're well worth the journey.
Even though Menorca is the smallest of the three main Balearic islands, it doesn't feel small at all. It took us just short of an hour to get to the lighthouse, and would have taken much longer to get to the western side of the island. Most of the best spots are tucked away up windy paths and barely-there roads, so going by car or moped is the only way to see them.
Nissan Electric ESP lent us one of their electric cars to take for a spin around the island for a day, so Emily, Emily, Scott and I did a speed tour of Favaritx ligthhouse and the Mola Fortress on the eastern coast. It started with the touch of a button and was almost silent to drive (although we may have been blasting out Dizzee Rascal's 'Bonkers' too loudly to have known...).
The car is part of a larger island-wide project to transform Menorca's energy sources. At the moment, 97% of energy is produced by fossil fuels, transported to the island by boat, so Menorca is moving towards using its natural resources as much as possible. Kinda geeky, but also pretty cool - and I'll take a green island over a party island any day.
4 - Visit a quarantine island
Just off the coast of Menorca's capital city, Mahón, sits el Llatzaret - one of the quarantine stations built in the 18th Century. These quarantine islands were an essential stop for people and boats passing through to Mahón's harbour, designed to stop the spread of the Plague. You can visit this island and it may just be one of the THE coolest things to do in Menorca - or even the whole of Spain!
We caught our first glimpse of the island on our first day in Menorca, when we took a catamaran along the eastern coast. It's a great way to see the island from above and glimpse into the super clear sea that surrounds it, but it's also well worth exploring el Llatzaret by foot.
Much like Menorca, it's surprisingly big and eerily deserted, and made a really unusual spot for the opening party of the #MustSeeMenorca conference! There's also a whispering arch to add to the eeriness of the island. If someone stands in the opposite corner and speaks to the wall, it sounds like they're right next to you - even though you can't hear the voices in the rest of the room.
The takeaway? A visit to Menorca can be whatever you want it to be. It can be fast or slow, as jam-packed or as peaceful as you like, a solo escape or fun for the whole family. One thing that's for sure is that this little spot of hidden paradise will surprise you.
Have you ever thought about visiting Menorca? What do you think of when you hear the name?
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Jodie Marie Dewberry
Jodie has been travelling the world full time since 2017, sharing the most unique places in the world along with tips for living as a digital nomad. She has worked with a number of prominent travel brands, including airlines, tourism boards, hotels and tour operators.
2 Comments
That is a great post :) You are so right, not even a lot of people in Europe know that island of Menorca exist :D I plan to go there next summer, so I am saving your post for future reference :) thank you, I would love to do the kayaking :)Reply
It's a must place to go :) great adventure to do. Nice pictures bdw :)Reply


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Aaron Norris is joined this week by Senator Bob Wieckowski on the radio show. This is our weekly radio broadcast. We recorded the show with Bob back in September and will be featuring him on the radio show starting this morning. If you're in the Inland Empire, tune in live to KTIE 590AM on Saturday morning. Or, you can listen to the show here on our website.
November 24, 2018 @ 10:00 am - 11:00 am
This week, Aaron Norris is joined by Senator Bob Wieckowski. He was elected in 2014, and he represents the 10th Senate District in the California State Legislature. The district stretches from Southern Alameda County into Santa Clara County. He serves on a number of Senate committees as well, including judiciary, budget and fiscal review, transportation and housing, and ethics. He has been one of the leading voices pushing for housing solutions, including legislation on accessory dwelling units. He hopes to help out with California's affordability issues and lack of new construction. His background is as a small business owner and bankruptcy attorney.


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A connected church can do more.
Bring people, ministry, and operations together in one place. Realm is our next-generation Web and mobile ChMS that equips your staff and connects your church.
Cathy Carpenter of Our Lady of Victory Parish discusses how Constant Contact, via PDS, has greatly improved the communications between her church and parishioners.


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Career Opportunities
Rhode Island
Treatment for children who are Deaf/HOH using ASL
Perspectives Corporation is seeking caring individuals with basic to proficient skills in ASL to work in the homes of Deaf/Hard-of-Hearing or hearing children with a variety of needs.
Behavior Specialists will work directly with the child with the involvement of a clinical team, with the goal of implementing and modeling strategies to parents, teachers, and care givers to foster independence in the child's home, school and community.
As part of the treatment team, this position will receive regular supervision and support from a licensed clinician.
Candidates must have at least one year of college level education or currently be enrolled in a minimum of 6 college credits; have a favorable criminal background check, favorable driving record, and DCYF clearance. Proficient users of American Sign Language (ASL) and bilingual Spanish/English candidates encouraged to apply.
Perspectives offers competitive pay, flexible schedules, a generous benefits package, tuition reimbursement, advancement opportunities and much more.
We provide a wide variety of training programs, on-line and in-person, including a comprehensive New Employee Orientation designed to accommodate those who have never worked with people with developmental disabilities.


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The Senate Education Committee, chaired by state Sen. Luther Olsen (R-Ripon), will hold a public hearing today (Jan. 21) on two bills dealing with schools collecting and reporting crime-related data:
Thursday, January 21, 2016
411 South
Senate Bill 492 Relating to: a student safety incident tracking pilot program for school districts and making an appropriation.
By Senators Lazich, Darling, Gudex and Wanggaard; cosponsored by Representatives Skowronski, Nerison, R. Brooks and Allen.
WASB is neutral on this bill but we prefer the approach of a voluntary pilot program to a statewide mandate. View our testimony here.
Senate Bill 470 Relating to: reporting crimes and other incidents that occur on school property, on school transportation, and at school sanctioned events and granting rule-making authority.
By Senators Wanggaard and Darling; cosponsored by Representatives Jagler, J. Ott, Sanfelippo, Murphy, Loudenbeck, Quinn, R. Brooks, Tittl, Allen, Vorpagel, Weatherston, Hutton, Knodl, Tranel, Ripp, Kerkman, Brandtjen, Nygren, T. Larson, Petersen, Born, Ballweg, E. Brooks, Gannon and Nerison.
WASB has many concerns and is opposed to this bill. See our testimony.


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Remixing the Book World
Christine Prefontaine breaks publishing boundaries.
Having spent years working in communications for international development projects, Christine Prefontaine had long suspected that there was more to be gained than lost from sharing ideas, or even from having them stolen. Not only did sharing seem to solve problems more quickly, but it also raised the profile of the idea's originator. And it wasn't ideas that ensured success, she reasoned, but the ability to come up with them—something nobody could steal.
After more than a decade working in the U.S. and pondering how open-source technologies and other forms of "open culture" might affect community, research, and personal success, Prefontaine returned to Montreal last year to find many of her thoughts had become established practice. Volunteers were making free internet increasingly available, freelance workers were sharing space and collaborating, and a local project called LibriVox had created the largest audio-library in the world, entirely drawn from the public domain and available for free.
Without missing a beat, Prefontaine launched a project of her own, Artefatica, which will publish openly-licensed books that anyone can take or use. What are such experiments in open culture accomplishing?
Sarah Colgrove: Why create books that will go directly into the public domain where they can be copied?
Christine Prefontaine: Remix has been done for songs and video and multimedia, and Artefatica aims to enable it with books. We want to create books with very open licenses—either with public domain or a Creative Commons attribution-sharealike license, where you have to cite what you take and allow others to do the same with your work. This could create a kind of chain where people can collaborate and add to each other's creations over time. It allows us to come together around ideas and issues.
I'm testing out whether we can make money creating books that people can take and republish, and my hunch is yes, since we will be selling signed and numbered versions of a work of art in book form. The other thing I'm testing is how to use the Creative Commons license. There are many contributors to our first book, and I'm trying to tell them all what it means to license their content so that other people can take it and use it themselves. How do I attribute it? Their name? The book's name? What does the person who takes it and uses it say? What about the person ten years down the line? Actually creating objects with this new licensing structure is complicated.
SC: Were you inspired by the success of the Montreal project LibriVox?
CP: I'm not a member of that community, but to me it's a really successful and fascinating example of how one person picks up on other people's ideas, adds their own spin, and quickly a community builds to contribute to the public good.
Basically, LibriVox takes items out of the Gutenberg project—which is putting all public domain work onto the internet—and gets people together to make mp3 files out of them. They've been wildly successful: it's the largest audio library in the world, with audio-books available in many languages. All these books are now accessible for the blind, and for people in their cars on long commutes, and they're free.
SC: You're also a member of Station C, a co-working space. How has it impacted your work?
CP: The concept of Artefatica was developed with other members of Station C. We are a bunch of freelancers or people with full-time jobs who can work remotely. It's not a non-profit, although our aim is just to be self-sustaining. Working in the same space allows people to share clients and resources if they want to. All the work I'm doing now has come to me through Station C.
We all work independently but close together, no cubicles, no hierarchy. What happens is that we end up sharing ideas and advice with one another. Even people who are competitors working in the same field can end up collaborating because one person can only handle so many projects. Also, we can come together to bid on a large project like an agency would. So you can be a small independent worker but quickly pull together an ad-hoc team of really high quality people.
Since there's no bureaucracy, you don't have to work with someone again if you don't like the quality of their work. Everyone has to be very good at what they do, because if you can't pay for your desk you have to leave. There's a certain insecurity to that, but perhaps that's not accurate: in this economic climate, Station C members are thriving while many large organizations are unloading people.
Pick up Issue 33 of Maisonneuve for Chris LaVigne's article on the coming revolution of open-source democracy.


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Effects of fatigue on human performance – Why the TSB investigates for fatigue in every occurrence
12 March 2015
Posted by: Missy Rudin-Brown
Despite the fact that most people need around 8 hours of sleep every night to feel well-rested, 30% of Canadians report getting fewer than 6 hours of sleep per night, and 60% report feeling tired "most of the time".Footnote 1 Historically, getting by on as little sleep as possible – especially in some industries such as commercial fishing, rail operations and aviation – was seen as a necessary part of operations rather than as something that needed to be discouraged. Insufficient or poor quality sleep due to long working hours, sleeping at a time of day when one is usually awake, or being awake at a time of day when one usually sleeps, are all factors that contribute to fatigue and the resulting feeling of tiredness. "Fatigue" is the feeling of tiredness that one experiences when not getting enough, or enough good quality, sleep. People working in today's 24/7, 'non-stop service' transportation industry, are particularly at risk of experiencing fatigue.
How fatigue affects performance
Fatigue can affect a person's performance in a variety of ways. People who are fatigued are more easily distracted, are less able to concentrate, tend to forget things more easily, take longer to solve problems, make more mistakes, have slower reaction times, and take more risks than they might otherwise. At the extreme, they might fall asleep while operating a vehicle! But the risks of fatigue in terms of transportation safety are not limited to vehicle operators. The performance of individuals in other roles, for example managers who schedule work and oversee operations, traffic control officers, mechanics, technicians, baggage handlers, and those providing customer service, can also negatively impact safety if it is impaired by fatigue. Being tired can also make a person feel angry or irritable, which can affect the performance of those around them.
Investigating for fatigue
Because fatigue is so common and accepted in our society today, it is necessary for investigations to consider it in every occurrence. As investigators, we need to rigorously collect sleep data as soon as possible during an investigation.
Did fatigue exist?
A first step is to request sleep-wake and work histories for all operational personnel involved in an occurrence. To help with this process, the TSB has developed an innovative tool for investigating fatigue that can be used to collect and analyse data. This tool is used to convincingly document the existence of fatigue in transportation accidents, as well as its influence on safety, so that those responsible for transportation safety management will be in a better position to implement effective solutions, such as fatigue risk management programs (FRMS). People's memory of their sleep patterns fade quickly. That's why interviews need to be conducted as soon as possible after an accident. Investigators will ask about a person's normal sleep habits – how long and at what time they usually sleep when they have every opportunity to get rest. They will also assess a person's physical characteristics, ask about medical conditions, the use of alcohol or drugs (including prescribed and over-the-counter medication), and the sleep environment. Obstructive sleep apnea, sleep walking, night terrors, and restless legs syndrome are other sleep-related conditions that can limit the quality and quantity of sleep a person obtains.
Did fatigue contribute to the occurrence?
Once it is determined that fatigue was present at the time of an accident, we need to determine whether it influenced safety and contributed to the occurrence. Just because someone was in a fatigued state during the lead-up to an accident does not necessarily mean that fatigue's effect on performance contributed to the accident. Understanding whether the causal or contributing performance impairments could have been due to fatigue is normally a matter of comparison of the observed behaviour(s) to the known, typical effects of fatigue, as well as other potential contributing factors. If a person's performance impairment was related to information processing, decision-making, attention, mood, or reaction time, then it is possible that fatigue played a role.
Regardless of its source, fatigue in individuals who are responsible for transportation safety is a risk that needs to be understood and mitigated. As many transportation industries operate around the clock, fatigue and its effects cannot be eliminated completely; however, it must be managed. A first step in this process is for TSB investigators to document the prevalence and role of fatigue in transportation accidents that occur. To assist, the TSB has just released the Guide to investigating sleep-related fatigue, which contains the fatigue data collection and analysis tool. Please contact us for more information on fatigue, or to request a copy of the Guide. You can email us at firstname.lastname@example.com or call 1-800-387-3557 (extension 2).
Christina (Missy) Rudin-Brown has been a Senior Human Factors Investigator with the TSB since 2012. She has been studying the effects of human factors issues – such as impairment from fatigue, distraction, drugs and alcohol – on operator behaviour in a variety of transportation modes for over 20 years. She lives in Ottawa with her husband and three daughters and, in her spare time, loves to travel and stay fit.
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An Interview With an Ex-Scientologist
Posted by Wickedpinto on November 4, 2010
Jason Beghe, who you might recognize, I mostly remember him as Tom Yinessa from 1st and 10, talks about his experience with scientology.
I really don't care about Scientology myself, don't judge the run of the mill Scientologist, even people like John Travolta and Tom Cruise. I guess they're happy and quirky and the average person doesn't have to deal with them, so fine. This interview, however, shows some strange stuff.
Language warning.
That is just part one, all 13 cuts, or the full unedited can be found if you go to Youtube. If bored and curious can also checkout Operation Clambake.
This entry was posted on November 4, 2010 at 12:13 pm and is filed under education, free speech, moonbats, moral authority, religion, video. You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.


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Engraved wedding ring in platinum. A smoothly conforming D-shape band, the full circumference engraved with stylised flower motifs with light ridged detail to the sides, approximately 2.4mm in width. Marked platinum and iridium, further engraved 'With all my heart Love Paul 10-26-46', American, circa 1946.


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Poems and Stories of Awakening
The poetry and stories in this book provide historical insight into how Buddhism became one of the first religions to welcome women and offers inspiration for anyone looking for spiritual role models. Diana Winston's moving introduction is a personal testament to the power of this book to change lives.
This book is not as significant as Great Disciples of the Buddha, but it is important.


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- Description
DetailsPCT Map -Northern Oregon - Map #8 Get the latest in the U.S. Forest Service award-winning Pacific Crest National Scenic Trail map series! This new map (#8) covers the PCT's approximately 240 miles in northern Oregon from Twin Peaks to the Oregon/Washington border. Informative and stunning, the map provides detailed topographic information, geographic coordinates, and elevation profiles. Access roads, trailheads and feeder trails are depicted. Text and photographs highlight ecologic, geologic, historic, and other features of the PCT in the region. Printed on lightweight water- and tear-resistant paper.
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zemplar (paricalcitol) injection, solution
[Abbott Laboratories]
Paricalcitol, USP, the active ingredient in Zemplar Injection, is a synthetically manufactured analog of calcitriol, the metabolically active form of vitamin D indicated for the prevention and treatment of secondary hyperparathyroidism associated with chronic kidney disease(CKD) Stage 5. Zemplar is available as a sterile, clear, colorless, aqueous solution for intravenous injection. Each mL contains paricalcitol, 2 mcg or 5 mcg; propylene glycol, 30% (v/v); and alcohol, 20% (v/v).
Paricalcitol is a white powder chemically designated as 19-nor-1α,3β,25-trihydroxy-9,10-secoergosta-5(Z),7(E),22(E)-triene and has the following structural formula:
Molecular formula is C27H44O3.
Molecular weight is 416.64.
Secondary hyperparathyroidism is characterized by an elevation in parathyroid hormone (PTH) associated with inadequate levels of active vitamin D hormone. The source of vitamin D in the body is from synthesis in the skin and from dietary intake. Vitamin D requires two sequential hydroxylations in the liver and the kidney to bind to and to activate the vitamin D receptor (VDR). The endogenous VDR activator, calcitriol [1,25(OH)2 D3], is a hormone that binds to VDRs that are present in the parathyroid gland, intestine, kidney, and bone to maintain parathyroid function and calcium and phosphorus homeostasis, and to VDRs found in many other tissues, including prostate, endothelium and immune cells. VDR activation is essential for the proper formation and maintenance of normal bone. In the diseased kidney, the activation of vitamin D is diminished, resulting in a rise of PTH, subsequently leading to secondary hyperparathyroidism, and disturbances in the calcium and phosphorus homeostasis.1 The decreased levels of 1,25(OH)2 D3 and resultant elevated PTH levels, both of which often precede abnormalities in serum calcium and phosphorus, affect bone turnover rate and may result in renal osteodystrophy.
Paricalcitol is a synthetic, biologically active vitamin D analog of calcitriol with modifications to the side chain (D2) and the A (19-nor) ring. Preclinical and in vitro studies have demonstrated that paricalcitol's biological actions are mediated through binding of the VDR, which results in the selective activation of vitamin D responsive pathways. Vitamin D and paricalcitol have been shown to reduce parathyroid hormone levels by inhibiting PTH synthesis and secretion.
Within two hours after administering Zemplar intravenous doses ranging from 0.04 to 0.24 mcg/kg, concentrations of paricalcitol decreased rapidly; thereafter, concentrations of paricalcitol declined log-linearly. No accumulation of paricalcitol was observed with multiple dosing.
Paricalcitol is extensively bound to plasma proteins (≥99.8%). In healthy subjects, the steady state volume of distribution is approximately 23.8 L. The mean apparent volume of distribution following a 0.24 mcg/kg dose of paricalcitol in CKD Stage 5 subjects requiring hemodialysis (HD) and peritoneal dialysis (PD) is between 31 and 35 L.
After IV administration of a 0.48 mcg/kg dose of 3H-paricalcitol, parent drug was extensively metabolized, with only about 2% of the dose eliminated unchanged in the feces and no parent drug found in the urine. Several metabolites were detected in both the urine and feces. Most of the systemic exposure was from the parent drug. Two minor metabolites, relative to paricalcitol, were detected in human plasma. One metabolite was identified as 24(R)-hydroxy paricalcitol, while the other metabolite was unidentified. The 24(R)-hydroxy paricalcitol is less active than paricalcitol in an in vivo rat model of PTH suppression.
In vitro data suggest that paricalcitol is metabolized by multiple hepatic and non-hepatic enzymes, including mitochondrial CYP24, as well as CYP3A4 and UGT1A4. The identified metabolites include the product of 24(R)-hydroxylation (present at low levels in plasma), as well as 24,26- and 24,28-dihydroxylation and direct glucuronidation.
Paricalcitol is excreted primarily by hepatobiliary excretion. Approximately 63% of the radioactivity was eliminated in the feces and 19% was recovered in the urine in healthy subjects. In healthy subjects, the mean elimination half-life of paricalcitol is about five to seven hours over the studied dose range of 0.04 to 0.16 mcg/kg. The pharmacokinetics of paricalcitol has been studied in CKD Stage 5 subjects requiring hemodialysis (HD) and peritoneal dialysis (PD). The mean elimination half-life of paricalcitol after administration of 0.24 mcg/kg paricalcitol IV bolus dose in CKD Stage 5 HD and PD patients is 13.9 and 15.4 hours, respectively (Table 1).
CKD Stage 5-HD
CKD Stage 5-PD
† harmonic mean± pseudo standard deviation, HD: hemodialysis, PD: peritoneal dialysis
|Cmax (ng/mL)
|1.680 ± 0.511
|1.832 ± 0.315
|AUC0-∞ (ng·h/mL)
|14.51 ± 4.12
|16.01 ± 5.98
|β (1/h)
|0.050 ± 0.023
|0.045 ± 0.026
|t1/2 (h) †
|13.9 ± 7.3
|15.4 ± 10.5
|CL (L/h)
|1.49 ± 0.60
|1.54 ± 0.95
|Vdβ (L)
|30.8 ± 7.5
|34.9 ± 9.5
The degree of accumulation was consistent with the half-life and dosing frequency.
The pharmacokinetics of paricalcitol have not been investigated in geriatric patients greater than 65 years.
The pharmacokinetics of paricalcitol have not been investigated in patients less than 18 years of age.
The pharmacokinetics of paricalcitol were gender independent.
The disposition of paricalcitol (0.24 mcg/kg) was compared in patients with mild (n=5) and moderate (n=5) hepatic impairment (as indicated by the Child-Pugh method) and subjects with normal hepatic function (n=10). The pharmacokinetics of unbound paricalcitol were similar across the range of hepatic function evaluated in this study. No dosing adjustment is required in patients with mild and moderate hepatic impairment. The influence of severe hepatic impairment on the pharmacokinetics of paricalcitol has not been evaluated.
The pharmacokinetics of paricalcitol have been studied in CKD Stage 5 subjects requiring hemodialysis (HD) and peritoneal dialysis (PD). Hemodialysis procedure has essentially no effect on paricalcitol elimination. However, compared to healthy subjects, CKD Stage 5 subjects showed a decreased CL and increased half-life (see Pharmacokinetics- Elimination).
An in vitro study indicates that paricalcitol is not an inhibitor of CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, or CYP3A at concentrations up to 50 nM (21 ng/mL) (approximately 20-fold greater than that obtained after highest tested dose). In fresh primary cultured hepatocytes, the induction observed at paricalcitol concentrations up to 50 nM was less than two-fold for CYP2B6, CYP2C9 or CYP3A, where the positive controls rendered a six- to nineteen-fold induction. Hence, paricalcitol is not expected to inhibit or induce the clearance of drugs metabolized by these enzymes.
Drug interactions with paricalcitol injection have not been studied.
The pharmacokinetic interaction between paricalcitol capsule (16 mcg) and omeprazole (40 mg; oral) was investigated in a single dose, crossover study in healthy subjects. The pharmacokinetics of paricalcitol were unaffected when omeprazole was administrated approximately 2 hours prior to the paricalcitol dose.
Although no data are available for the drug interaction between paricalcitol injection and ketoconazole, the effect of multiple doses of ketoconazole administered as 200 mg BID for 5 days on the pharmacokinetics of paricalcitol capsule has been studied in healthy subjects. The Cmax of paricalcitol was minimally affected, but AUC0-∞ approximately doubled in the presence of ketoconazole. The mean half-life of paricalcitol was 17.0 hours in the presence of ketoconazole as compared to 9.8 hours, when paricalcitol was administered alone (See PRECAUTIONS).
In three 12-week, placebo-controlled, phase 3 studies in chronic kidney disease Stage 5 patients on dialysis, the dose of Zemplar was started at 0.04 mcg/kg 3 times per week. The dose was increased by 0.04 mcg/kg every 2 weeks until intact parathyroid hormone (iPTH) levels were decreased at least 30% from baseline or a fifth escalation brought the dose to 0.24 mcg/kg, or iPTH fell to less than 100 pg/mL, or the Ca × P product was greater than 75 within any 2 week period, or serum calcium became greater than 11.5 mg/dL at any time.
Patients treated with Zemplar achieved a mean iPTH reduction of 30% within 6 weeks. In these studies, there was no significant difference in the incidence of hypercalcemia or hyperphosphatemia between Zemplar and placebo-treated patients. The results from these studies are as follows:
(No. of Pts.)
|Baseline Mean
|Mean (SE) Change From Baseline to Final Evaluation
|PTH (pg/mL)
|Zemplar (n = 40)
|783 (291 – 2076)
|-379 (43.7)
|placebo (n = 38)
|745 (320 –1671)
|-69.6 (44.8)
|Zemplar (n = 31)
|150 (40 – 600)
|-41.5 (10.6)
|Phosphatase (U/L)
|placebo (n = 34)
|169 (56 – 911)
|+2.6 (10.1)
|Calcium (mg/dL)
|Zemplar (n = 40)
|9.3 (7.2 – 10.4)
|+0.47 (0.1)
|placebo (n = 38)
|9.1 (7.8 – 10.7)
|+0.02 (0.1)
|Phosphorus (mg/dL)
|Zemplar (n = 40)
|5.8 (3.7 – 10.2)
|+0.47 (0.3)
|placebo (n = 38)
|6.0 (2.8 – 8.8)
|-0.47 (0.3)
|Calcium ×
|Zemplar (n = 40)
|54 (32 – 106)
|+7.9 (2.2)
|Phosphorus Product
|placebo (n = 38)
|54 (26 – 77)
|-3.9 (2.3)
A long-term, open-label safety study of 164 CKD Stage 5 patients (mean dose of 7.5 mcg three times per week), demonstrated that mean serum Ca, P, and Ca × P remained within clinically appropriate ranges with PTH reduction (mean decrease of 319 pg/mL at 13 months).
Zemplar is indicated for the prevention and treatment of secondary hyperparathyroidism associated with chronic kidney disease Stage 5.
Zemplar should not be given to patients with evidence of vitamin D toxicity, hypercalcemia, or hypersensitivity to any ingredient in this product (see WARNINGS).
Acute overdose of Zemplar may cause hypercalcemia, and require emergency attention. During dose adjustment, serum calcium and phosphorus levels should be monitored closely (e.g., twice weekly). If clinically significant hypercalcemia develops, the dose should be reduced or interrupted. Chronic administration of Zemplar may place patients at risk of hypercalcemia, elevated Ca × P product, and metastatic calcification.
Treatment of patients with clinically significant hypercalcemia consists of immediate dose reduction or interruption of Zemplar therapy and includes a low calcium diet, withdrawal of calcium supplements, patient mobilization, attention to fluid and electrolyte imbalances, assessment of electrocardiographic abnormalities (critical in patients receiving digitalis), hemodialysis or peritoneal dialysis against a calcium-free dialysate, as warranted. Serum calcium levels should be monitored frequently until normocalcemia ensues.
Phosphate or vitamin D-related compounds should not be taken concomitantly with Zemplar.
Digitalis toxicity is potentiated by hypercalcemia of any cause, so caution should be applied when digitalis compounds are prescribed concomitantly with Zemplar. Adynamic bone lesions may develop if PTH levels are suppressed to abnormal levels.
The patient should be instructed that, to ensure effectiveness of Zemplar therapy, it is important to adhere to a dietary regimen of calcium supplementation and phosphorus restriction. Appropriate types of phosphate-binding compounds may be needed to control serum phosphorus levels in patients with chronic kidney disease (CKD) Stage 5, but excessive use of aluminum containing compounds should be avoided. Patients should also be carefully informed about the symptoms of elevated calcium (see ADVERSE REACTIONS).
During the initial phase of medication, serum calcium and phosphorus should be determined frequently (e.g., twice weekly). Once dosage has been established, serum calcium and phosphorus should be measured at least monthly. Measurements of serum or plasma PTH are recommended every 3 months. An intact PTH (iPTH) assay is recommended for reliable detection of biologically active PTH in patients with CKD Stage 5. During dose adjustment of Zemplar, laboratory tests may be required more frequently.
Paricalcitol is not expected to inhibit the clearance of drugs metabolized by cytochrome P450 enzymes CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, or CYP3A nor induce the clearance of drug metabolized by CYP2B6, CYP2C9 or CYP3A.
Specific interaction studies were not performed with Zemplar Injection.
A multiple dose drug-drug interaction study with ketoconazole and paricalcitol capsule demonstrated that ketoconazole approximately doubled paricalcitol AUC0-∞ (see CLINICAL PHARMACOLOGY). Since paricalcitol is partially metabolized by CYP3A and ketoconazole is known to be a strong inhibitor of cytochrome P450 3A enzyme, care should be taken while dosing paricalcitol with ketoconazole and other strong P450 3A inhibitors including atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin or voriconazole.
Digitalis toxicity is potentiated by hypercalcemia of any cause, so caution should be applied when digitalis compounds are prescribed concomitantly with Zemplar.
In a 104-week carcinogenicity study in CD-1 mice, an increased incidence of uterine leiomyoma and leiomyosarcoma was observed at subcutaneous doses of 1, 3, 10 mcg/kg (2 to 15 times the AUC at a human dose of 14 mcg, equivalent to 0.24 mcg/kg based on AUC). The incidence rate of uterine leiomyoma was significantly different than the control group at the highest dose of 10 mcg/kg.
In a 104-week carcinogenicity study in rats, there was an increased incidence of benign adrenal pheochromocytoma at subcutaneous doses of 0.15, 0.5, 1.5 mcg/kg (< 1 to 7 times the exposure following a human dose of 14 mcg, equivalent to 0.24 mcg/kg based on AUC). The increased incidence of pheochromocytomas in rats may be related to the alteration of calcium homeostasis by paricalcitol.
Paricalcitol did not exhibit genetic toxicity in vitro with or without metabolic activation in the microbial mutagenesis assay (Ames Assay), mouse lymphoma mutagenesis assay (L5178Y), or a human lymphocyte cell chromosomal aberration assay. There was also no evidence of genetic toxicity in an in vivo mouse micronucleus assay. Zemplar had no effect on fertility (male or female) in rats at intravenous doses up to 20 mcg/kg/dose [equivalent to 13 times the highest recommended human dose (0.24 mcg/kg) based on surface area, mg/m2].
Paricalcitol has been shown to cause minimal decreases in fetal viability (5%) when administered daily to rabbits at a dose 0.5 times the 0.24 mcg/kg human dose (based on surface area, mg/m2) and when administered to rats at a dose 2 times the 0.24 mcg/kg human dose (based on plasma levels of exposure). At the highest dose tested (20 mcg/kg 3 times per week in rats, 13 times the 0.24 mcg/kg human dose based on surface area), there was a significant increase of the mortality of newborn rats at doses that were maternally toxic (hypercalcemia). No other effects on offspring development were observed. Paricalcitol was not teratogenic at the doses tested.
There are no adequate and well-controlled studies in pregnant women. Zemplar should be used during pregnancy only if the potential benefit to the mother justifies the potential risk to the fetus.
Studies in rats have shown that paricalcitol is present in the milk. It is not known whether paricalcitol is excreted in human milk. In the nursing patient, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
The safety and effectiveness of Zemplar were examined in a 12-week randomized, double-blind, placebo-controlled study of 29 pediatric patients, aged 5-19 years, with end-stage renal disease on hemodialysis and nearly all had received some form of vitamin D prior to the study. Seventy-six percent of the patients were male, 52% were Caucasian and 45% were African-American. The initial dose of Zemplar was 0.04 mcg/kg 3 times per week based on baseline iPTH level of less than 500 pg/mL, or 0.08 mcg/kg 3 times a week, based on baseline iPTH level of ≥ 500 pg/mL, respectively. The dose of Zemplar was adjusted in 0.04 mcg/kg increments based on the levels of serum iPTH, calcium and Ca x P. The mean baseline levels of iPTH were 841 pg/mL for the 15 Zemplar-treated patients and 740 pg/mL for the 14 placebo-treated subjects. The mean dose of Zemplar administered was 4.6 mcg (range: 0.8 mcg – 9.6 mcg). Ten of the 15 (67%) Zemplar-treated patients and 2 of the 14 (14%) placebo-treated patients completed the trial. Ten of the placebo patients (71%) were discontinued due to excessive elevations in iPTH levels as defined by 2 consecutive iPTH levels > 700 pg/mL and greater than baseline after 4 weeks of treatment.
In the primary efficacy analysis, 9 of 15 (60%) subjects in the Zemplar group had 2 consecutive 30% decreases from baseline iPTH compared with 3 of 14 (21%) patients in the placebo group (95% CI for the difference between groups –1%, 63%). Twenty-three percent of Zemplar vs. 31% of placebo patients had at least one serum calcium level > 10.3 mg/dL, and 40% vs. 14% of Zemplar vs. placebo subjects had at least one Ca x P ion product > 72 (mg/dL)2. The overall percentage of serum calcium measurements > 10.3 mg/dL was 7% in the Zemplar group and 7% in the placebo group; the overall percentage of patients with Ca x P product > 72 (mg/dL)2 was 8% in the Zemplar group and 7% in the placebo group. No subjects in either the Zemplar group or placebo group developed hypercalcemia (defined as at least one calcium value > 11.2 mg/dL) during the study.
Of the 40 patients receiving Zemplar in the three phase 3 placebo-controlled CKD Stage 5 studies, 10 patients were 65 years or over. In these studies, no overall differences in efficacy or safety were observed between patients 65 years or older and younger patients.
Zemplar has been evaluated for safety in clinical studies in 454 CKD Stage 5 patients. In four, placebo-controlled, double-blind, multicenter studies, discontinuation of therapy due to any adverse event occurred in 6.5% of 62 patients treated with Zemplar (dosage titrated as tolerated, see CLINICAL PHARMACOLOGY - Clinical Studies) and 2.0% of 51 patients treated with placebo for 1 to 3 months. Adverse events occurring with greater frequency in the Zemplar group at a frequency of 2% or greater, regardless of causality, are presented in the following table:
|Adverse Event
Zemplar (n = 62)
Placebo (n = 51)
|Body as a Whole
|Feeling unwell
|Cardiovascular System
|Digestive System
|Dry mouth
|Gastrointestinal bleeding
|Metabolic and Nutritional Disorders
|Nervous System
|Respiratory System
A patient who reported the same medical term more than once was counted only once for that medical term.
Safety parameters (changes in mean Ca, P, Ca × P) in an open-label safety study up to 13 months in duration support the long-term safety of Zemplar in this patient population.
Potential adverse events of Zemplar Injection are, in general, similar to those encountered with excessive vitamin D intake. Signs and symptoms of vitamin D intoxication associated with hypercalcemia include:
Weakness, headache, somnolence, nausea, vomiting, dry mouth, constipation, muscle pain, bone pain, and metallic taste.
Anorexia, weight loss, conjunctivitis (calcific), pancreatitis, photophobia, rhinorrhea, pruritus, hyperthermia, decreased libido, elevated BUN, hypercholesterolemia, elevated AST and ALT, ectopic calcification, hypertension, cardiac arrhythmias, somnolence, death, and rarely, overt psychosis.
Taste perversion, such as metallic taste, and allergic reactions, such as rash, urticaria, pruritus, facial and oral edema rarely have been reported.
Overdosage of Zemplar may lead to hypercalcemia, hypercalciuria, hyperphosphatemia, and over suppression of PTH. (see WARNINGS).
The treatment of acute overdosage should consist of general supportive measures. Serial serum electrolyte determinations (especially calcium), rate of urinary calcium excretion, and assessment of electrocardiographic abnormalities due to hypercalcemia should be obtained. Such monitoring is critical in patients receiving digitalis. Discontinuation of supplemental calcium and institution of a low calcium diet are also indicated in acute overdosage.
General treatment of hypercalcemia due to overdosage consists of immediate suspension of Zemplar therapy, institution of a low calcium diet, and withdrawal of calcium supplements. Serum calcium levels should be determined at least weekly until normocalcemia ensues. When serum calcium levels have returned to within normal limits, Zemplar may be reinitiated at a lower dose. If persistent and markedly elevated serum calcium levels occur, there are a variety of therapeutic alternatives that may be considered. These include the use of drugs such as phosphates and corticosteroids as well as measures to induce diuresis. Also, one may consider dialysis against a calcium-free dialysate.
The currently accepted target range for iPTH levels in CKD Stage 5 patients is no more than 1.5 to 3 times the non-uremic upper limit of normal.
The recommended initial dose of Zemplar is 0.04 mcg/kg to 0.1 mcg/kg (2.8 – 7 mcg) administered as a bolus dose no more frequently than every other day at any time during dialysis.
If a satisfactory response is not observed, the dose may be increased by 2 to 4 mcg at 2- to 4-week intervals. During any dose adjustment period, serum calcium and phosphorus levels should be monitored more frequently, and if an elevated calcium level or a Ca × P product greater than 75 is noted, the drug dosage should be immediately reduced or interrupted until these parameters are normalized. Then, Zemplar should be reinitiated at a lower dose. If a patient is on a calcium-based phosphate binder, the dose may be decreased or withheld, or the patient may be switched to a non-calcium-based phosphate binder. Zemplar doses may need to be decreased as the PTH levels decrease in response to therapy. Thus, incremental dosing must be individualized.
The following table is a suggested approach in dose titration:
|PTH Level
|Zemplar Dose
|the same or increasing
|decreasing by < 30%
|decreasing by > 30%, < 60%
|decreasing by > 60%
|one and one-half to three times upper limit of normal
The influence of mild to moderately impaired hepatic function on paricalcitol pharmacokinetics is sufficiently small that no dosing adjustment is required.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration whenever solution and container permit.
Discard unused portion.
Zemplar Injection is available as 2 mcg/mL (NDC 0074-4637-01) and 5 mcg/mL (NDC 0074-1658-01 and NDC 0074-1658-02).
|List No.
|Total Content
|1 mL/Fliptop Vial
|2 mcg/mL
|2 mcg
|1 mL/Fliptop Vial
|5 mcg/mL
|5 mcg
|2 mL/Fliptop Vial
|5 mcg/mL
|10 mcg
Store at 25°C (77°F). Excursions permitted between 15° - 30°C (59° - 86°F).
U.S. patents: 5,246,925; 5,587,497; 6,136,799; 6,361,758
© Abbott 2005
Manufactured by
Hospira, Inc.
Lake Forest, IL 60045 USA
Abbott Laboratories
North Chicago, IL 60064, U.S.A.
|ZEMPLAR (paricalcitol)
|ZEMPLAR (paricalcitol)
Data are from FDA and U.S. National Library of Medicine.


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Hello, It is an honor to have you here, in our creative home if you will. This website is only the beginning of what you will see produced by Machine & Emotion. As Machine, I've been asking myself what my goals are so I can … Continue readingHello from machine


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Whilst The Payments System Regulator announced it will consult on ways to compensate those who are duped into sending cash online to fraudsters it really does pay to try to be one step ahead.
Double checking the sort code and account number only with the intended recipient (that you know to be true) will help ensure you do not fall foul to a fraudster masquerading as the legitimate solicitor, builder, shop etc.
As I understand it the Sort Code and Account Number are only cross-checked by a bank when making a transfer and not routinely the name. So if you are planning on paying ABC Limited £20k for building works and you apparently receive an email or text from them asking you to make payment in their name but to a different sort code and account number this should send alarm bells ringing!
Making a big payment to a builder, solicitor or friend through online banking? Double-check the account number and sort code before you hit send, because you are still unlikely to get any money back if it goes straight into the hands of a criminal, despite moves by the regulator to crack down on what is known as push-payment fraud. The Payments System Regulator announced this week that it will consult on ways to compensate those who are duped into sending cash online to fraudsters. It also wants to make it harder for them to open bank accounts to collect their illegal earnings.


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It appears there are more controversial stories behind Ebony's trip and her tragic death than it has been currently thrown on Ghanaians.
READ ALSO: Ebony speaks about how female artists in the music industry hated her before her death(Video)
Newly gathered information available at Ghpage.com reveal that Ebony, a day before her deadly accident, informed her managers that she was embarking on a trip to the Northern Region.
This new information is in distinction to what has already been aired to the public that Ebony intentionally traveled to visit her mother in the Brong Ahafo Region before her death.
Speaking in an interview on GhOne TV as watched by Ghpage.com, Allen Kofi Anti, Deputy Manager of Ruff Town Records, Ebony's record label, made this shocking revelation.
According to the Deputy manager, on Wednesday, February 7, 2018, Ebony called him on the phone in the evening to tell him of her journey to the North.
READ ALSO: Ebony's 17 mysterious tattoos finally uncovered
Allen on his response to Ebony's farewell call said, considering the time Ebony called him, he tried to convince her not to go on that journey but she refused to listen and simply replied him "Don't worry, I will be fine."
Upon further narration, he disclosed that even on her way to the North, Kaywa, a sound engineer who declared to have predicted Ebony's death, also called her on the phone and warned her to return home but Ebony disregarded his warning too and continued her trip.
On the other hand, Bullet who was in the same interview with his Deputy Manager added that Ebony became so powerful that nothing could stop her from doing what pleases her whenever she wanted something.
READ ALSO: Video: Ebony was childless but was a mother for all, her presence fed some of us
So even though Allen informed him of Ebony's decision to visit the North at that sole hour, he could hardly do something about it, especially when he was out of the country and never got the message early due to the difference in timezone and internet problems.
READ ALSO: 'Angel' Obinim finally speaks about Ebony's death (Audio)
Per the two managers account, Kaywa had told them many months ago of an imminent accident ahead of Ebony and had also given them some directions to take to avoid that catastrophe and they heeded.
They added that upon all the warnings and revelations made about Ebony, and for her to disregard Kaywa's warning on her way to the North is something serious.
Their revelation also hints that Ebony had actually visited the Northern Region a day before her death for a reason no one knows till now, and upon her return from the North that she made a brief stop at her mother's house in Sunyani.
Another disclosure made by the managers is that they have no idea about Ebony's many tattoos, including her choice of designs and shape.
They also revealed that counter to claims by Ebony's father that the soldier, Lance Corporal Vondee Francis Atsu, who died with Ebony, was her personal bodyguard, they never knew of it, and didn't know the driver either, but only Franky Kuri, her personal assistant.


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At St Edward's College we continue to strive to create a positive school climate that values and accepts all students. Therefore the Learning Support Department continues to implement the policy of inclusive education for all, by supporting students with special learning needs in the context of their mainstream classroom. In addition to this approach, some special clinics are offered to small groups and individuals targeting particular skills. This includes reading intervention programs such as, Multilit, offered to small groups before school.
In Year 7, we are able to target a number of students by offering smaller classes that have teacher assistant support for subjects, such as, English and Mathematics. In addition, students can access online resources, such as, MathsOnline and Education Perfect, designed to independently improve students' specific academic skills.
Another initiative, provided by the Learning Support team, offers Homework Help in the library before school. Here students may work independently or seek teacher assistance with the completion of homework or more complex research tasks. The Learning Support team specifically run workshops during this time, such as, Multilit, and maths tutoring. Students are also provided with the opportunity to access computers, iPads and a range of other educational technologies. For many boys their academic achievement has improved with the increased confidence and self-esteem gained by this service.
Another support provided to eligible students for common assessment tasks, is the use of Disability Provisions, previously known as Special Provisions. This ensures that all students have equal access to realising their potential under test conditions. This role is ongoing and particularly important to those students sitting external NESA assessments during their Higher School Certificate. It is important to acknowledge the valued support and service that many of our more able students provide in acting as Readers and/or Writers for such common assessments. This program allows the volunteers to add these hours to their Waterford Projects through the service they provide to others.
At St Edward's College we are fortunate to have four very experienced teacher assistants who contribute to the ongoing individual and collective learning needs of students in the classroom. The learning support staff are very empathetic and considerate to the needs of all students and, under the direction of classroom teachers, our aim is to continually make appropriate adjustments in the classroom to suit the learning and personal needs of students.
Although the Learning Support Department specifically targets students with learning needs that require a range of adjustments, our presence in the College benefits all students, allowing teachers and assistants to work as a team to improve learning outcomes for all. The College relies on the ongoing support of parents and caregivers in this education process by endeavouring to maintain effective home-school links. This is based on mutual respect, recognition of equity of the differing roles of parents and educators and the sharing of relevant information. With this partnership we aim to provide the best learning gains for all students using the resources we have.


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Community, communication, collaboration: Scholarly practice in transformation
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The Next Wave of Collaboration: Educause Australasia 2005
April 5-8, 2005
Auckland, New Zealand.
This paper reports on the results of a survey and focus groups exploring the use of the Internet by academic staff and research students at Curtin University of Technology for the purposes of scholarly communication. The survey included questions regarding the respondents' formal and informal scholarly communication practices and the way in which these have changed as the result of access to the Internet. The survey also asked a range of questions regarding respondents' use of library services, the frequency of their use of these services, and the manner in which their use of the library had been impacted by the increasing availability of Internet based access to services and collections. Whilst focus group discussions suggested some ambivalence towards the enabling potential of ICTs on scholarly communication, the evidence gathered indicates the extent to which research and communicative practice is changing and the resultant impact on scholarly communities. The paper concludes with some preliminary observations about changes to scholarly communities and the opportunity this offers for academic librarians to enhance their role in the development of research literate communities.
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Presented as part of Carnegie Hall's Migrations: The Making of America Festival
Part of NYTF's Global Yiddish Theatre Restoration Project initiative, this concert brings history to life by reviving the lost and forgotten pieces of the Yiddish stage!
From the Yiddish Rialto to the Silver Screen features songs from jazz-infused Yiddish musicals, hits made popular on the Yiddish radio, and melodies accompanied by film clips (courtesy of National Center for Jewish Film) from the Yiddish musical cinema of the 1930s and 1940s. Songs will be performed in Yiddish with English supertitles.
The concert stars: Glenn Seven Allen ( Amerike – the Golden Land, The Golden Bride),Daniel Greenwood ( The Mikado), Maya Jacobson ( Fidler Afn Dakh, Amerike – The Golden Land), Joseph Mace ( The Golden Bride), Rachel Policar ( The Golden Bride),Daniella Rabbani ( The Golden Land), and Steve Sterner ( The Sorceress), and features the Uptown Downtown Orchestra conducted by Zalmen Mlotek.
VILNA the play – Get a 10% discount on advance sale tickets! Special Talk-Back Performances from March 12th – March 31st
Theatre at St. Clement's
423 West 46th Street in the theater district.
Click here to: Purchase Advance Sale VILNA Tickets for $54.00 and $69.50 tickets
VILNA tells the heroic story of Motke Zeidel and Yudi Farber, actual people, who come of age in the remarkable city of Vilna during its degradation in the Interwar years and destruction in World War II. As their world collapses they repeatedly face painful moral and life-threatening choices to save others.
For more information about the play go to www.vilna-the-play.org.


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With local elections taking place in just a few weeks, voters in West Lancashire are being urged to make sure they are registered to vote and are able to take part on polling day, Thursday 4 May.
The call for voters to sign up comes after the Electoral Commission launched a national voter registration campaign to encourage as many people as possible to register ahead of elections taking place this year across the country.
West Lancashire Borough Council is also reminding voters in the area that they need to register by the deadline of Thursday 13 April. Otherwise they won't be able to take part in the Lancashire County Council elections taking place on Thursday 4 May.
Kim Webber, Electoral Registration Officer for West Lancashire said: "Time is running out to make sure you can take part in elections this May, so I'd encourage everyone in West Lancashire to take action now if they're not already registered to vote. It's quick and easy to register, but after the deadline of 13 April, it will be too late."
Emma Hartley, Head of Campaigns at the Electoral Commission said: "Our research shows that young people, students and recent home movers are particularly less likely to be registered to vote. So if you have moved house recently, then make sure you're registered correctly. If you're not registered, you won't be able to have your say on issues that directly affect your day-to-day life in West Lancashire"
To register to vote, visit Register to vote or Register to vote (external link) before Thursday 13 April.


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GREAT BRIGHT. Mandrill Garage's 'Orange Shark' KTM Racer
Posted on October 11, 2018 by Andrew in Racer. No Comments
It's taken a lot longer than we'd like, but there's some cool custom bikes coming out of China. And with more money being thrown around in Beijing than at a bikie strip show there will be more. The custom bike scene will be huge there some day. And in the years to come they will look back at shops like Madrill Garage…


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About the Producer
The Mellot name has been associated with wine since 1513. César Mellot gained his reputation as wine advisor to Louis XIV, and was the head of a long dynasty of passionate winegrowers whose know-how has been passed from generation to generation. Today, Catherine oversees the Joseph Mellot estate's 90 hectares in all of the Centre-Loire region's appellations.
Today, Jospeh Mellot is at the fore front of environmentally friendly wine making. At the present time in France, there is a great deal of media coverage about the highly successful 10:10 campaign initiated by the photographer Yann Arthus Bertrand.
Joseph Mellot, a family-run estate that specializes in the production of Loire Valley wines from the Centre region, joined the campaign in the autumn of 2009. It was the first winery and the first French company to make the 10:10 commitment.
The estate decided to publicize its commitment to the campaign by featuring the 10:10 logo on its "green" bottle – an original way to communicate the 10:10 message with the first 10:10 wine! The Green Bottle, made out of PET (weighing 54 grams as opposed to 480 grams for a glass bottle), has already been launched in the English market. The 10:10 campaign naturally fits in with the estate's strong environmental position which has been acknowledged by ISO 14001 certification.
During this period, the winery considerably improved its ecological footprint with a 10.3% reduction in the emission of greenhouse gases resulting from packaging (the biggest source of CO2 emissions in the carbon footprint assessment). This was made possible by reducing the weight of glass bottles (the average weight of an empty bottle went from 473g in 2008 to 446g in 2009 and by launching the PET bottle.
This represents a savings of 19 tons of CO2, the equivalent of driving your car 94,000 miles.
Concurrently, all of the actions Joseph Mellot has taken have resulted in a considerable 25% reduction in fuel consumption (or the equivalent of driving 15,500 miles).
The winery has also chosen to improve upon the disposal of its waste (plastic, cardboard, glass) through specialized channels, allowing for better recycling and additional carbon savings.
All of the tours of the Joseph Mellot estates are conducted in small electric cars.Visit Producer's Website


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Icicle – Entropy LP (Shogun Audio)
Posted by Adam on 18th November 2014
The much anticipted new album from Icicle, Entropy, has landed.
3 years on from his debut LP 'Under The Ice' Icicle returns with a new, forward thinking album.
As well as including the massive lead singles Problem & The Edge the album is, from start to finish, filled with so many great tracks spanning multiple tempos and is a master class in production.
Here's a few words from the man himself…
"My first album 'Under The Ice', was an attempt to showcase my influences and where I came from musically, it was in a sense retrospective. This new album is more of a look into what I think the future of this sound could be. The term 'Entropy' means a 'state of disorder' or 'measure of chaos' which I felt was a great metaphor for how my production style has evolved, diversified and developed over the years." Icicle – www.shogunaudio.com


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We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
Australian Longhaired Sheepskin Chair Cushion - Champagne
Looking for a way to make your favourite dining chairs more comfortable and cosy? Our sheepskin cushions are the perfect accessory to add some warmth and extra padding to your seats, fitting perfectly on the majority of dining chairs and bar stools. These work particularly well on wooden, metal or plastic seats. Also available in mushroom.
Height: 50cm
Width: 42cm
UK Standard Parcel 2-4 Working Days - £5.50
UK Next Working Day - Order before 1pm - £7.50
UK Saturday or Sunday Delivery - £15
UK Click & Collect - from our Altrincham Showroom - Free
No hassle returns policy – just notify us within 14
days of delivery


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The structure of the Osinovaya Roshcha Logistic Park includes a container yard with area of 50000 sq m.
- The surface of container area made from reinforced concrete slab.
The surface load – 100 t/sq m.
Capacity of lump storage is 2500 40-feet containers.
The height of storage is 5 layers.
Electric light – 40LUX.
The safety is guaranteed is provided by 24-hours security system.
- storage of containers (including temperature controlled containers);
- handling of containers for custom clearance and veterinary control;
- pre-departure inspection;
- weighing.


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Adventure Film Makers 2020 on-line entry form
There are three steps in the entry process:
- Fill in and click on the Submit button on the online entry form below
- You will be sent a confirmation email with a Paypal link to pay the $25 entry fee. Note if you do not receive this confirmation email please contact us to see if we have received your entry -you may have made a mistake in your email address.
- Ensure you have sent us a link to download (preferred) or preview your movie.
|Please send the following items after you have submitted the form (before April 20):
Rules and Entry Details
- The Judges reserve the right to withhold prizes in any category they consider not to be of a sufficiently high standard. Their decision will be final and neither the judges nor the organisers will enter into any correspondence regarding their decisions.
- All cash prizes are in New Zealand and American dollars
- Awards may be presented to the director or the producer of the film.
- Special Jury Awards may be given to films deserving recognition.
- Entries are not limited to one award and many films could fit into a couple of categories.
- Please indicate if you are also entering the New Zealand filmmakers category.
- The dispatching of any entry to the festival implies acceptance of these procedures and regulations by the entrant.
- Entries can be of any duration, in either: narrative, story, animated or experimental art form, and can be submitted by professional or amateur filmmakers.
- Filmmakers from any country may enter the festival.
- The Best New Zealand made film prize must be collected by a New Zealand citizen or resident, but need not necessarily be filmed in New Zealand.
- The judges decision will be final.
- Entries with soundtracks in any language other than English MUST be accompanied by an English translation in sub titles and/or narrative.
- Entries MUST be accompanied by a summary of the film.
- Films must either be in English, or have English subtitles.
- An admission charge will be made to the public in order to defray the costs of the festival.
- Receipt of entries will be acknowledged by the festival organisers as long as the correct e-mail address is supplied and ONLY if a request made.
- Finalists will be notified by June 1st, 2020.
- The entrant acknowledges and agrees that all maters not covered by these Regulations, and questions arising from them, will be decided by festival organisers or the festival jury at their sole discretion.
Technical Requirements
We like all films to be supplied as .mov or .mp4 files with dimensions of 1920 x 1080. 1080p and h264 codec.
All entries will be viewed prior to the festival by a pre-selection committee chaired by the Festival Director. Finalists chosen by this committee will be screened by the public over the festival. Winners will be announced approximately 4 weeks prior to the festival. The jury reserves the right not to make an award, and its decision will be final.
Entries can be a DVD posted to us but we prefer to download a computer file via your FTP, our dropbox or from your Vimeo site. PAL standard preferred (but NTSC accepted). DVD's SHOULD NOT be copy protected as the films will be copied onto a hard drive for screening during the festival. All computer files and DVDs are destroyed after the festival and we take great pride in not sharing your hard work with ANYONE. We download all films for judging in April/May.
Promotional Material
Entries should be accompanied by two images from the film for the festival promotional use. Photos saved as jpegs can be posted or e-mailed.
Please include a compressed press kit and a brief director's CV, if available.
By entering into the festival, the entrant represents and warrants that:
i. It has the authority to enter the film in the festival.
ii. It owns all rights, title and interest, including the copyright and all intellectual property rights, in and to the film being submitted to the festival and has the rights to distribute, exhibit and promote the film in or through all media formats.
iii. No material in the film being submitted by the entrant to the festival is libellous or defamatory or violates and rights of privacy or publicity of any person and the full use of the rights in such film will not violate any rights, including copyright or moral rights, of any person, firm or corporation.
The entrant agrees to indemnity the NZ Mountain Film Festival, their respective successors, licensees, and their respective officers, directors, members, agents and employees and hold them harmless from and against any and all claims, liability, losses, damages, costs, expenses (including reasonable legal fees), and penalties arising out of, resulting from, based upon or incurred because of a breach by the entrant of any statement, representation or warranty made by the entrant in the entry form, these procedures and regulations.
Entry Instructions
- Entry forms (online), promotional images, along with two copies of the film (DVD) must be sent PREPAID by airmail, parcel post or courier in bubble packaging.
- DVDs can be returned if return freight cost is prepaid. Entries from outside of New Zealand will need a customs declaration. Please state GOODS FOR EXHIBITION AND RETURN and put a nominal value of US$10
- The greatest possible care will be taken to prevent loss or damage from occurring to the films, no responsibility for loss or damage will be accepted by the festival organisers.
NZ Mountain Film Festival
P.O.Box 563
Wanaka 9343
New Zealand
NZ Mountain Film Festival
17 Drake Place, Lake Hawea
RD2, Wanaka, 9382, New Zealand
Any other questions or inquires should be directed to the Festival Director, Mark Sedon. E-mail: firstname.lastname@example.com. Phone +64 27 490 9003.


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How will GDPR impact your business?
In this age of digital transformation, protecting privacy and security have become top of mind. On 25 May 2018, General Data Protection Regulation (GDPR) will come into effect, impacting organizations worldwide that have any dealings with consumers and businesses in European Union (EU) member states.
The truth is that many companies just don't understand what they have to do to comply with GDPR and how to start their journey. Therefore it is critical for Canadian organizations doing business in the EU to gain a deeper understanding of how the free flow of personal information must be maintained. To that end, these companies need to have an adequate privacy ecosystem in operation which is aligned to the requirements of the GDPR.
To learn more about the GDPR journey and its impact on your business, listen to the KPMG and Microsoft GDPR Virtual Conference recordings below.
Request for proposal


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Happy Stacking the Shelves day!
Stacking The Shelves is a weekly meme hosted by Tynga's Reviews. Be sure to check out her site where you can find the link to the others participating in this meme.
Mouse Scouts by Sarah Dillard (Knopf)
Mouse Scouts: Make a Difference by Sarah Dillard (Knopf)
Girl in the Blue Coat by Monica Hesse (Little Brown, BFYR)
Unhinge by Calia Read (Ballantine)
Lost Stars by Claudia Gray (Disney Lucasfilms Books)
Going Where It's Dark by Phillips Reynolds Naylor (Delacorte)
The Goblin's Puzzle by Andrew Chilton (Knopf)
The Cat Who Came in off the Roof by Annie Schmidt (Reprint/Delacorte)
Mr. Lemoncello's Library Olympics by Chris Grabenstein (Random House BFYR)
The Geek's Guide to Unrequited Love by Sarvenaz Tash (S&S BFYR)


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Spiritual Scientist
eike studied Biotechnology and received her Ph.D. in Freiburg, Germany. In 2014, she started to travel the world in search of a deeper meaning to life. It was the spirit of India, which led her to the discovery of Sacred Geometry and Metaphysics. She founded In 2 Infinity in 2017 together with Colin to spread this fascinating knowledge, combining her passion for science, spirituality, and art in one project.
Musician & Metaphysician
olin Power is a life long musician and workshop facilitator. Traveled extensively throughout his life, he has conversed with a large variety of spiritually minded people, particularly on the subject of Buddhism and Hinduism. His entry into the world of Metaphysics began when he became interested in creating alternative energy generation, based on Vedic mathematics of vortexes.


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Street Fighter 2 Pinball
Street Fighter 2 Pinball Game
Street Fighter II is a pinball machine designed by Premier/Gottlieb in cooperation with Capcom, and released in early 1993, based on the popular video game of the same name.
The object of the game is to defeat each of twelve opponents by making the appropriate shot when the white light with the opponent's name is on. In normal settings, before the first Champion Challenge, there are always 3 opponents lit at a time, starting with E.Honda, M.Bison, and Sagat. Every time you defeat an opponent, you get a choice of prizes, which is selectable by the flippers.
|27"W x 55"L x 76"H
|120v AC, 5amps
Share this game with your friends or colleagues:


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The chilli flakes make this hearty breakfast dish, adding depth and a lot of spice. It takes minutes to make and yet is impressive, healthy, and satisfying.
Makes 1
1 tablespoon olive oil
1 cup (packed) cleaned and roughly chopped kale
½ cup cooked quinoa
1 garlic clove, minced
1/2 teaspoon chilli flakes (more if you like spicy)
6 cherry tomatoes cut in half
2 shallots, thinly sliced
1 teaspoon red wine vinegar
2 tablespoons crumbled feta
1 poached / boiled or fried egg
1. Heat olive oil over medium-high heat in a medium sauté pan. Add kale, season with a pinch of salt, and sauté for about one minute. Add minced garlic clove and chilli flakes and sauté for another 30 seconds, or until the garlic becomes fragrant but hasn't turned brown. Add cooked quinoa, and sauté for one minute.
2. Add cherry tomatoes, shallots, and vinegar, and turn off heat. Toss to combine, and check for seasoning.
3. To serve, plate the mixture, garnish with feta cheese, and top with the egg
By Elle May


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The New York Times
The Big Idea
The New York Times has a yearly tradition of "Maker Week," a weeklong hackathon when people form teams across departments to work on a product idea.
Our team came up with the concept of localized news, which we called TLocal. And within a week—when we managed to find time away from our day-to-day work 🙂 —we built a standalone web app to demonstrate this idea in two ways:
1) News Near You: The app displays news based on users' GPS location.
2) News from elsewhere: Users choose a place on a map, and the app displays news from that location.
Ultimately, we believe this could be a feature of the NYT mobile and web app experience.
The app can also extend to additional features such as reviews and augmented reality (AR)


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Snack Review
Taste test: These large pretzel nuggets had a split top, with a light helping of salt on the sides.
Each nugget seemed to have a hollow area inside. The soughdough didn't have all that much taste, but the pretzels were crisp and had a good crunch. They sure packed a lot of pretzel nuggets into this 20-oz. bag.
Shop: Buy Pretzels on Amazon #ad
Smell test: Not much.
From the package: "From purified water" ... "A Cholesterol-Free Food" ... "Enjoy the Taste!" ... "The Pretzel Men"
Online store: Buy Pretzels on Amazon #ad
Company: Benzel's Bretzel Bakery, Inc.
Categories for this snack:
This snack was contributed to Taquitos.net by the manufacturer. Review published .
Most popular in previous months
Still hungry? Check out the 100 latest reviews


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The school day begins with everyone singing the national anthem, and all children should be in school from 7.30am and no later than 7.40am.
The times by years group are below.
Sunday to Wednesday
FS1 & FS2: 7.40am to 1.45pm
Year 1 to Year 6: 7.40am to 2.45pm
Year 7: 7.30am to 2.45pm
FS1 & FS2: 7.40am to 1.15pm
Year 1 to Year 6: 7.40am to 1.20pm
Year 7: 7.30am to 1.20pm
FS After School Care
To make life easier for families with children in FS1 and FS2 we are pleased to offer an after school care service for one hour every Sunday to Wednesday (1.45pm-2.45pm)
Whole School Breakfast and After School Club
From September 2019, we will be introducing additional options to support our working families. We will be offering breakfast and after school clubs. These will run on a paid basis with discounted rates for booking bulk in advance.
Breakfast club: 6.45am to 7.30am (Sunday to Thursday)
After school club: 2.45pm to 4.15pm (Sunday to Wednesday), 2.45pm to 3.15pm (Thursday)
During both breakfast and after school club the children will receive light refreshments and take part in a range of fun activities. For all of the above, the children will be supervised by school staff.
For details on rates, please speak to our finance team or refer to the family handbook.


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Welcome to Ms. Hardesty's US History Classroom
This is the place to keep up to date with the classroom's homework assignments, web resources and documents.
In your American History Class, we will explore history through the use of historical inquiry practices, primary source documents, political cartoons, films, literature and music. We will examine history as a record of where our country has been, and as an explanation for many of our traditions, customs, and present culture. We will consider what voices were trusted and which were silenced in the writing of our shared past. Although the class will primarily rely on interactive lecture, the real goal of this class is for students to hone their interpretive and analytical skills that will assist them in future social science endeavors as well as in other academic and social arenas.
If you have any comments, questions, or concerns please feel free to contact me.
Looking for your assignment instructions or a due date?
Check the Calendar page!