text:
Discourse, Film
An event of the transcultural festival POSTWEST
With: Caspar Dohmen (journalist and author, Berlin), Michal Hába (theater director, Prague), Marta Kahancová (Central European Labour Studies Institute, Bratislava), Apolena Rychlíková (film director, Prague)
Moderation: Gabriele Freitag (German Association for East European Studies, Berlin)
They work in slaughterhouses and industrial laundries, as waste sorters, as cashiers, and on assembly lines. Unregulated working hours, night shifts, wages that barely cover the basics, work that is hazardous and dangerous to health—the everyday life of hundreds of thousands in Eastern Europe, and likewise of migrant workers in Germany. Right-wing populists, of all people, seek to capture votes by declaring themselves protectors of the poor. But what can really be done to improve the working and living conditions of those without whose labors modern societies would not function? What role is played by the making-visible of these abuses via journalistic and artistic means? The investigative journalist Saša Uhlová experienced the illegal working conditions faced by low-wage earners in the Czech Republic by working for several months in various companies while filming with a hidden camera. With her series of articles The Heroes of Capitalist Labour and the documentary The Limits of Work, she and collaborating director Apolena Rychlíková, brought the reality of life for workers to the attention of society. For the transcultural festival POSTWEST, the theatre director Michal Hába brings The Heroes of Capitalist Labour to the stage for the first time.
Following the panel discussion, the film The Limits of Work (Czech Republic 2017) will be shown in original language with English subtitles.
Caspar Dohmen is an economics journalist and author of numerous books about the dark sides of the global economy. His most recent books are Schattenwirtschaft. Die Macht der illegalen Märkte (The Shadow Economy: The Power of Illegal Markets, 2019), Das Prinzip Fair Trade (The Fair Trade Principle, 2017) and Proftigier ohne Grenzen. Wenn Arbeit nichts mehr wert ist und Menschenrechte auf der Strecke bleiben (Greed without Borders: When Work Isn't Worth It and Human Rights Fall by the Wayside, 2016).
Michal Hába is a Czech theatre director, working in both independent and state run-theatres. He focuses on political topics, using Brechtian principles. Michal graduated from the Academy of Performing Arts in Prague(direction) and is the artistic director of Lachende Bestien. Productions include Sezuan based Bertolt Brecht, Heiner Müller's Mission, An Enemy of the People based on Henrik Ibsen and Pornogeography by Werner Schwab for which he received the Josef Balvin Award in 2016 (Best German Language Play of the Year).
Marta Kahancová is the managing director of Central European Labour Studies Institute (CELSI) in Bratislava. Her research interests are in sociology of organizations and work: she studies work practices and social interaction in multinational firms, industrial relations and work-related migration.
Apolena Rychlíková is a Czech documentarist, publicist and journalist. She has long been interested in social issues, particularly inequality, poverty and social exclusion. As the author of several movies she cooperates with the Czech TV and Czech Radio. Her feature length debut The Limits of Work (2017) was awarded Czech Joy at IDFF Jihlava 2017, audience Award and the award of the Czech film critics in the category Best television title and it was screened at numerous international festivals.
Gabriele Freitag is executive director of the German Association for East European Studies (Deutsche Gesellschaft fuer Osteuropakunde / DGO) in Berlin. Previously she was as research associate at the Research Center for East European Studies, University of Bremen, programme director at the Foundation Remembrance, Responsibility and Future (Stiftung Erinnerung, Verantwortung und Zukunft) and managing director of the Berlin Graduate School Muslim Cultures and Societies at Freie Universität Berlin.
In cooperation with
Funded by the German Federal Cultural Foundation
Photo source: Pixabay. Credit: anaterate
Upcoming Activities:
Der Weg aus der Nische? Belarussische Literatur und ihre Zukunft, 18.02.
Platform East: An Unholy Alliance? "Christian Values" and Anti-Gender Politics in Central and Eastern Europe, 26.02.
Platform East: Fragmente meiner Heimaten. Russischsprachige Migration in Deutschland, 18.03.
An event of the transcultural festival POSTWEST
Panel I. Senka Maric (Mostar), Jeton Neziraj (Pristina)
Moderation: Doris Akrap (taz, Berlin)
Panel II. Lana Bastasic (Belgrade, Barcelona), Rumena Buzarovska (Skopje)
Moderation: Tino Schlench (literaturpalast, Vienna)
A buffer zone in tense times and a melting pot of various cultural and political influences? From the perspective of Southeastern Europe, the cultural and political notions of East and West have always been complex and in a constant state of flux. In a conversation about their literary works, four authors discuss different concepts of East and West—and the recurring question of belonging—from the perspective of Southeastern Europe. To what extent are the perceptions of East and West shaped by different regional, local, and individual contexts? For example, what is the role played by the historical narratives that are being increasingly exploited for political purposes during and after the wars in former Yugoslavia? To what extent are these perceptions influenced by experiences of migration or generational conflicts? Has language become a political issue as a result? Does gender play a role? And how is all of this reflected in literature? Ultimately, how do East and West position themselves in a geographical, political, and cultural space that belongs to both and neither at the same time?
The discussion is followed by a concert of Damir Avdić—a musician and lyricist whose distorted guitar riffs and haunting voice hit all the sore spots precisely and confronts the audience with their own prejudice, comfort and hipocrisy.
Lana Bastašić is a Yugoslav-born writer. She studied English Language and Literature and holds an MA degree in Cultural Studies. She has published two collections of short stories and one of poetry. Uhvati zeca (Catch the Rabbit), her first novel, was published in 2018. She co-founded Escola Bloom in Barcelona and she co-edits the school's literary magazine Carn de cap.
Rumena Bužarovska was born in 1981 in Skopje, Northern Macedonia. She has authored four short story collections, a booklet of flash fiction, as well as a study on humor in contemporary American and Macedonian short fiction. She is a literary translator from English into Macedonian and associate professor of American literature at the State University in Skopje. She is co-initiator and co-organizer of the PeachPreach women's storytelling event and hosts a radio show under the same name.
Senka Marić is a Bosnian poet, short stories writer, essayist, translator, and editor. She was born in 1972 and has published three books of poetry and her first novel Kintsugi tijela (Body Kintsugi) was awarded the Meša Selimović Prize in 2019. She is editor in chief of the online magazine for literature, art and culture Portal Strane (strane.ba).
Jeton Neziraj is a playwright and the Director of Qendra Multimedia. He has written over 25 plays that have been staged, translated and published widely in Europe and in the USA. The German theatre magazine Theater der Zeit and the German Radio Deutschlandfunk Kultur have described him as 'Kafka of the Balkans', while Los Angeles Times called him "a world- class playwright who challenges our complacency at every twist and turn".
Doris Akrap was born in 1974 Croatia and grew up in Flörsheim am Main. She studied cultural and religious studies in Berlin and works as a journalist and editor at taz. Her articles were also published in The Guardian and Die Zeit. Together with several other journalists, she founded the anti-racist reading show Hate Poetry.
Tino Schlench was Born in Uckermark/Brandenburg and holds a degree in cultural studies and modern German literature from the Humbold University in Berlin. After spending a year as visiting scholar at University of Berkley, Schlench started working as research associate at the Institute for Contemporary History in Vienna. In 2018, he started a literary blog @literaturpalast, focusing on literature from Eastern Europe.
In cooperation with
Funded by the German Federal Cultural Foundation
An event of the transcultural festival POSTWEST
I. Performance
Sarah Maria Sander: Die Geschichte meines Vaters (My Father's Story)
In 1946, Ibrahim Nadzhafow was born in Kharkov. His mother, a young Jewish woman, leaves her father, an Azerbaijani officer, after the birth and refuses him any contact with the son. He grows up longing for a father and gives himself the name Aleksander. In a distant country beyond the Soviet Union, he promises himself a future, a different, better world. Aleksander is stuck between eras and cultures, between searching and not-finding. Russia becomes alien, Germany remains unfamiliar even after years. Home becomes a utopia.
Many years later, Sarah grows up in Germany. She too is haunted by the question of home and identity. For her 18th birthday, her mother gives her an old wooden box. Inside are letters, postcards, and telegrams from Alexander's confidants, telling his story from their point of view.
II. Panel with Tatiana Golova (ZOiS), Svetlana Müller (PANDA Theater e.V.) and Sarah Maria Sander (Volksbühne Berlin)
Russian-speaking migrants in Germany are often perceived as a homogenous group. Their places of origin, their routes, and the status they received upon arrival in Germany differ considerably. Their stories and memories appear in artistic forms of expression. Are these passed on to the next generation as part of identity? What do cultural and meeting places mean for migrant communities? How do new cultural projects beyond nostalgia emerge and how far do they involve people outside the community? Building on the performance Die Geschichte meines Vaters by Volksbühne ensemble member Sarah Maria Sander, sociologist Tatiana Golova explores these questions in a conversation with the artist and with Svetlana Müller of PANDA Theater. In doing so, she examines the political dimension of migrant identity projects and the role that entanglements with countries of origin still play today.
Tatiana Golova is a sociologist at the Center for Eastern European and International Studies (ZOiS) and works on transnational migrant networks on social media.
Svetlana Müller chairs the non-profit association PANDA nicht nur russisches Theater e.V., which has developed into an interdisciplinary art, political, and cultural platform in recent years.
Sarah Maria Sander is an actress at the Volksbühne. She grew up in Germany and Russia. In 2015 she was a guest student in the master acting class at Semen Spivak Theatre Academy Saint Petersburg, Russian State Institute of Performing Arts. From 2015 to 2019 she studied at the Ernst Busch Drama School in Berlin.
In cooperation with
Funded by the German Federal Cultural Foundation
An event of the transcultural festival POSTWEST
With: Regina Elsner (ZOiS, Berlin), Radoslav Stoyanov (Bulgarian Helsinki Commitee, Sofia)
Moderation: Patricia Hecht (taz, Berlin)
Input: Elżbieta Korolczuk (Södertörn University, Stockholm), Kristina Stöckl (University of Innsbruck)
Today, right-wing populist movements and authoritarian governments worldwide use "Christian values" to promote conservative social policies. They proclaim to represent what is supposedly "real" civil society, as opposed to the elites. In countries such as Russia, Poland or Bulgaria in particular, the anti-gender and pro-family agenda of right-wing parties strengthens those who are nationalist and critical of Europe. However, these movements are also part of international ultraconservative Christian alliances that view Eastern Europe as a new bastion for the defense of their values. For instance, these links are clearly evident at the World Congress of Families (WCF), where ultraconservative Christian groups and individuals gather to defend a traditionalist understanding of the family.
What are the driving factors behind this "unholy alliance" of religion and politics, in which gender is equated with demoralization? What role do the Catholic and Orthodox Churches play in this process? How do the different denominations of the Christian church position themselves and engage in this conflict of values?
Regina Elsner is a theologian and a researcher at ZOiS. Through the project Morality instead of peace, Regina Elsner is investigating the dynamics of Russian Orthodox social ethics since the fall of the Soviet Union.
Elżbieta Korolczuk is a sociologist, commentator and women's and human rights activist. She works at Södertörn University in Stockholm and teaches at the American Studies Center at Warsaw University. Her research interests involve: gender, social movements and civil society. She published numerous texts, e.g. on the women's movement and its relation with neoliberalism, on new forms of citizenship, politicization of reproduction and anti-gender mobilization in Poland and abroad.
Radoslav Stoyanov is a Bulgarian human rights activist with a focus on LGBTI issues. As a gay activist, he litigated many cases before the national equality body regarding public hate speech against sexual minorities. He is acting as a watchdog for right-wing conservative activities in Bulgaria. He is currently working as an expert in the Bulgarian Helsinki Committee and is pursuing a master's degree in law.
Patricia Hecht worked for radio and print in Germany, Mexico and Colombia, before she joined taz in 2012. She was editor on the Berlin desk and for the front page and is now gender editor on the politics desk, working for example on reproductive rights and antifeminism. She was part of the international research team Europe's Far Right, reporting on strategies and networks of European far right politics.
In cooperation with
Funded by the German Federal Cultural Foundation
Russian with translation into German
An event of the transcultural festival POSTWEST
A way out of the niche? Belarusian literature and its future
With: Julia Cimafiejeva (poet and translator), Andrej Januškevič (historian and publisher)
Moderation: Alexander Chertenko
Since the 1990s, Belarusian writers who do not belong to the official, pro-government writers' union and write in Belarusian have found themselves in a precarious position: due to a lack of support and systematic marginalization in public discourse, they are destined to a niche existence, both culturally and linguistically. Belarusian is regarded as secondary to Russian by the state, which is the main reason why language is regarded by many Belarusian authors as a medium of resistance—even including those who write in Russian themselves, such as Nobel Prize winner Svetlana Alexievich. Publishers dedicated to Belarusian-language literature are also faced with a double challenge: they must hold their ground against the dominance of Russian-language publications, most of which come from Russia. In addition to this their work is also shaped by cultural, political, and administrative restrictions.
Set against this difficult situation, a lively literary scene has developed in Belarus over the last two decades, with its own publishing houses, journals, literary critics, and prizes, and it is even gaining recognition beyond national borders. What conditions are the independent authors and publishers working under there? Who are their readers and how do they market their publications in a (linguistically) Russian-dominated book market? If language is a political issue, what does it mean to write and read in Belarusian? And what ultimately needs to happen in order to liberate their literature from its niche?
Julia Cimafiejeva is a Belarusian poet and translator. She has published two volumes of poetry so far: Kniha pamylak (The Book of Errors, 2014) and Cyrk (Circus, 2016; German translation, 2019) . Cimafiejeva is the co-founder of the online literary magazine PrajdziSvet (discontinued in 2018). In 2017 she curated the Znak rounasci (Equal Sign) literature festival. She also presented the television programme Remarka (Commentary).
Andrej Januškevič is a historian and proprietor of the independent publishing house in Minsk of the same name. He is also the founder of kniharnia.by, a literature distributor that disseminates and promotes contemporary Belarusian literature.
Alexander Chertenko is a German-Ukrainian literary and cultural scholar, Slavist, and comparatist, and is currently working at the Justus Liebig University in Giessen. In 2019 he was a visiting scholar at ZOiS (Center for East European and International Studies).
In cooperation with
Funded by the German Federal Cultural Foundation
Upcoming Activities:
Platform East: An Unholy Alliance? "Christian Values" and Anti-Gender Politics in Central and Eastern Europe, 26.02.
Platform East: Fragmente meiner Heimaten. Russischsprachige Migration in Deutschland, 18.03.
Dead-end Jobs: Precarious Work in Central and Eastern Europe and Beyond, 31.03.
An event of the transcultural festival POSTWEST
With Alexander Formosov (Dekabristen e.V., Berlin), Zuzanna Hertzberg (artist and activist, Warsaw), Sasha Kurmaz (artist, Kyiv), Lela Rekviashvili (Leibniz-Institut für Länderkunde, Leipzig)
Moderation: Tsypylma Darieva (ZOiS, Berlin)
One often hears people speaking of weak civil societies in the Eastern European context. The image of citizens intimidated into political passivity still persists all too stubbornly. Yet anyone taking a closer look is bound to notice that resistance to neoliberal and authoritarian structures has been stirring up in many Eastern European cities. This resistance is expressed in creative forms of protest, artistic interventions, and the (re)appropriation of urban space. Using photos and video material, activists, artists, and social scientists will show how diverse and dynamic contemporary urban activism in Eastern Europe is: from grassroots actions in Russian Murmansk and the mobilisation of street protests against construction projects in Tbilisi, through to artistic interventions in Ukrainian and Polish cities. They will discuss the various forms and effects of urban activism in Eastern Europe, while also assessing their regional specificities and global connections.
Alexander Formozov studied History, European Ethnology and Political Science in Moscow and Berlin. Alexander's main focus is on transdisciplinary projects and international exchange in the areas of urbanism, culture, non-formal education and civil society in Eastern Europe. He is currently working at the Dekabristen e.V. as a project coordinator of the educational project ACT|UP.
Tsypylma Darieva is a social anthropologist and a senior researcher at ZOiS, Berlin. Together with Carola Neugebauer she edited the forthcoming volume Urban Activism in Eastern Europe and Eurasia. Practices and Strategies, DOM Publishers.
Zuzanna Hertzberg is a painter, author of installations, performative actions and artivist. She deals with subjects of memory and body, as well as issues related to a broad sense of identity and geopolitics. Zuzanna earned her PhD degree at the Warsaw Academy of Fine Arts (2018) and participated in a number of exhibitions in Poland and abroad. She is member of Antifascist Coalition as well as co-founder of Jewish Antifascist Block.
Sasha Kurmaz is a post-conceptual multi-disciplinary artist with a graffiti background. In his artistic practice, he uses photography, urban intervention, and performative situations through which he analyzes the social and political interrelationships that address themes both poetic and political. His work is at once direct and open to interpretation.
Lela Rekhviashvili is a post-doctoral researcher at Leibniz Institute for Regional Geography, Leipzig. She is interested in political economy of post-socialist transformation(s), urban informality and mobility, and social movements. Her publications theorise intersection of marketization, social embeddedness and informality. Her upcoming research project will look into counter-hegemonic thought and practice of civil societies in former Soviet peripheries.
Which forms of civic engagement exist in Eastern Europe? Which agents are participating in the restructuring of public space? How has collective memory changed in the post-Soviet era? The new series Platform East will raise these questions and many others as part of the transcultural festival POSTWEST. Academics, artists, and activists from Central and Eastern Europe as well as various experts on Eastern Europe will address the socially relevant issues that affect their everyday lives: the freedom of art and media, the politics of memory and the construction of identities, generational relationships and conflicts as well as protest against political systems. Bringing together these different professions will produce mental collages that expand epistemic horizons and serve as the starting point for diverse future scenarios and a collective utopia of POSTWEST.
The series Platform East is a collaboration between the Centre for East European and International Studies (ZOiS) and the Volksbühne Berlin. Through panel discussions, films, lecture performances, and other formats, the series will function as a platform in the truest sense: at the intersection of art and science, it moves past the existing homogenous images of Eastern Europe and offers space for political, societal, and cultural diversity.
In cooperation with
Funded by the German Federal Cultural Foundation
An event of the transcultural festival POSTWEST
As a prelude to POSTWEST Festival in May 2020, the ensemble will thoroughly yet sensitively explore the world of POSTWEST and present artistic contributions on (un)familiar subjects and figures, their own ideas and approaches to the festival's theme. Get to know our ensemble in a completely different way, and let this snapshot for your mind and senses guide you around the evening performance and to POSTWEST Festival.
Funded by the German Federal Cultural Foundation
An event of the transcultural festival POSTWEST
With: Alice Bota (ZEIT), Dóra Diseri (n-ost), Tamina Kutscher (dekoder), Dariya Orlova (Mohyla School of Journalism)
Moderation: Gesine Dornblüth
The media shapes our perception of political events, people, public debates, countries – and the stereotypes associated with them – within society. When we think about Eastern Europe our judgments are also inevitably influenced by imagery constructed by the media through pictures and texts. But how accurate are these images and between what tensions are they created?
This event focuses on the representation of Eastern Europe in Western European media outlets and vice versa: What ideas does Germany have about Eastern Europe and how do they view "us" there? To what extent do reports in the media influence our perception of East and West and the construction of the stereotypes associated with them? What role do political and economic factors play? What level of responsibility do foreign correspondents have with regard to the dissemination and maintenance of stereotypes and what new challenges are they facing?
In this discussion, journalists and media experts use these questions to approach the status quo of the media landscape in Europe. Against the background of a perceived East-West divide, they identify influential factors and talk about possible future scenarios and the conditions they would require: What would media coverage that's free of the continuous construction and reproduction of stereotypes look like?
Dóra Diseri is a Berlin-based Hungarian journalist and project lead of the European cross-border grant program "Reporters in the Field" at n-ost (Network for Reporting on Eastern Europe). Until October 2018, she was the Berlin correspondent of the Hungarian news channel HírTV. She studied journalism, cultural and Eastern-European studies in Budapest, Leipzig and Berlin. Before moving to Berlin in 2012, she worked as a multimedia journalist and reporter in the news department of the Hungarian Public Television (MTVA) in Budapest.
Gesine Dornblüth is a journalist and was the Moscow correspondent for Deutschlandradio from 2012 to 2017. With her doctorate in Slavic Studies, Dornblüth has reported primarily for radio reports and features from Russia and other former Soviet countries since the 90s.
Tamina Kutscher is a trained journalist, historian and Slavonic studies scholar. In 2016, she became dekoder's editor-in-chief. dekoder is an online platform that connects the public spheres in Russia and Germany: It publishes translations of articles and reports in the other country's language and also provides context and expertise from universities. For this combination of journalism and scholarship, dekoder was honoured with the 2016 Grimme Online Award.
Dariya Orlova is a Senior Lecturer and Deputy Director for Research at the Mohyla School of Journalism (National University of Kyiv-Mohyla Academy, Ukraine). She holds a PhD degree in Mass Communications from Autonomous University of Barcelona. Her major academic interests include: media transformations in transition countries, political communication, journalism culture, media and national identity. She has also served as an independent media expert and researcher with NGOs and international development agencies and worked as a journalist prior to her academic career.
In cooperation with
Funded by the German Federal Cultural Foundation
Book premiere
English with consecutive translation into German by Johannes Hampel
An event of the transcultural festival POSTWEST
Susan Neiman (director of the Einstein Forum, Potsdam) talks with author Ivan Kastev about sources for the current global crises, on the occasion of the German-language release of his book The Light that Failed - A Reckoning.
After the fall of the Berlin Wall and the collapse of the Soviet Union, the model of liberal democracy was supposed to be the only alternative. Today the liberal world is breaking apart before our very eyes. Populism, nationalism and a departure from liberal democratic values are accompanying its downfall. The West won the Cold War, and yet it has lost its political relevance. How could it come to this?
In the political analysis presented in The Light that Failed, Ivan Krastev and Stephen Holmes argue that the supposed "end of history" turned out to be the beginning of an "Age of Imitation". For almost three decades the imperative for the East was: "Imitate the West"! Through this imperative, the life of the imitators was increasingly dominated by feelings of inadequacy, inferiority, dependence, and the loss of identity.
Ivan Krastev, born 1965 in Bulgaria, is a political scientist. He is the chairman of the Centre for Liberal Strategies in Sofia and permanent fellow at the The Institute for Human Sciences in Vienna, where he is head of the Democracy in Questionprogramme. Krastev writes for the international edition of The New York Times. His essay After Europewas published in 2017.
"Ivan Krastev is one of the great European minds of today." Timothy Snyder
"Reading Krastev is a pleasure, because a love of literature, political realism and the beauty of thought all flow together in the art of his style." Elisabeth von Thadden, DIE ZEIT
"Ivan Krastev is one of Europe's leading intellectuals." Madeleine Albright
Funded by the German Federal Cultural Foundation


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West of England Joint Spatial Plan: Towards the Emerging Spatial Strategy
Towards the Emerging Spatial Strategy Document
Likely mitigations and infrastructure required to support the emerging spatial strategy
It is recognised that provision of necessary infrastructure up front or phased to support development is critical to the successful delivery of the spatial strategy. Our transport network has an increasing volume of travel and complex travel patterns. This has contributed to a network that is often at capacity at peak times, with increased journey times and congestion. These impacts have been perceived as a barrier to securing sustainable economic growth. This threatens not only the productivity of our businesses and workforce but our ability to meet wider sustainable objectives such as reducing carbon emissions and improving air quality in our urban areas.
Transport investment can be a major influence on where development is located and how to create high quality places in which people want to live and work. Influencing the location of development will not of itself be sufficient to address the issue.
Integrating housing and employment development with investment in reliable, high quality transport choices will reduce the length and number of journeys to work, encourage more sustainable travel modes such as cycling, walking and public transport and reduce the reliance on car based journeys.
To support the additional development required as a result of the spatial strategy the approach to infrastructure provision seeks to:
- maximise the effectiveness of sustainable travel choices and encourage mode shift (to rail, MetroBus, Park & Ride, bus, cycling, walking) across the plan area;
- maximise the effectiveness of non-car mode choices for both urban living and new development outside existing urban areas;
- then, mitigate impacts of additional traffic, including investigation of junction capacity improvements, upgrades, new highway connections and traffic restrictions.
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subset: commoncrawl


text:
Just do it!
Have an unshaken belief in yourself
After finishing high school in 2010 I went right to college at Baruch. I heard they had an International Business major and I had my mind set on that degree. I was living in the city, working part/full time as a waitress and attending school, I WAS LIVING THE LIFE!
On March 4th, 2012 I found out I was pregnant.
Initial reaction: HAPPY! (& I saw pink)
Secondary reaction: OMG WHAT THE HECK *%!$@ !!!!
I was excited to be bringing a little person into the world but uneasy in regards to what that would mean for my professional desires. I was fortunate enough to have a stay at home mom while growing up. So I promised myself that I would be as involved as a stay at home mom, as much as possible, while still fulfilling my professional desire. I feel that's important for child development, mentally, emotionally and physically. I found myself feeling conflicted. I wanted to be there 24/7 for my baby but I also enjoyed school and knew I had to secure some sort of future in order to provide. So after my daughter was born, I returned to school. I was attending twice a week (still matriculated as a full time student) all while being a single mother. I had my work cut out for me. I strived to:
-Be accepted into Baruch's Zicklin School of Business
-Be one of 50 students to be selected to pursue a BBA in International Business
-Obtain A's for grades
-Be elected for a leadership role in a school club
-Land an internship
-Network to expand my professional network
-Nurturing my precious baby
-Staying up all night
-Exclusively breastfeed
-Providing a positive, learning, engaging home for my baby
Now that it's been nearly three years, I am beyond proud of my accomplishments. I have achieved each goal I set forth for myself. When I share my stories, I'm always asked "how do you do it?" Well, I have an amazing support system! My parents, sisters and friends have stood by my side every step of the way. I stated my dreams clearly to all and what they could do in order to assist me in my endeavors. But above all, I had an unshaken belief in myself. Whenever all odds are against me and the road of least resistance is beaconing my name, I look inside myself. I listen to what my true intuition is. Even if it is absolutely absurd, nearly impossible or opposite of how I initially planned things out; I just listen to my intuition. I just do it. Moreover, I remember something my father told me. "Your a Cheek, and Cheek girls don't give up!" Don't give up on yourself. It's honestly never too late to do anything. Be it, starting a business, learning a new language, or picking up and moving; just do it! No amount of money, societal affirmation, or convincing can get you to your destination.
Solely your intuition.
I am honored and excited to be sharing my opinions, stories and experiences with all of you. I suggest feedback, commentary and dialogue, as that's the basis of entrepreneurship or as I put it, "the power of people." Please feel free to reach me at email@example.com. xo


text:
NJ Breeder of Chesapeake Bay
Retrievers, Labradors and Golden Retrievers
GCH Pennylane November Rain
OFA EL35872, OFA CA27806, OFA EYE5530/2018-51, DM clear, Ichthyosis clear, PRA1
clear, PRA2 clear, PRA-PRCD clear, Sensory Ataxic Neuropathy clear, OFACL5-766
Neuronal Ceroid Lipofuscinosis
MBISS GCH/Can CH Easthill Broxden Woodland Turnip The Volume
OS SDHF TDInc
Pennylane Yankee Just A Dream
3-24-18 great weekend for Gunner at the New Brunswick Kennel Club
Shows.Thursday BOS and Friday/Saturday back to back BOB and new Grand
Champion! Owner/Beryl Scaggs and Handler/Kristin Lyons
View Health info on the
OFA website
Redlion's Found In The Fourrest
EYE13410/2019-30, OFA CA32342 clear, DM clear, PRA-1 clear, PRA-2 clear, PRA-PRCD
clear, Ichthyosis clear
Hillock's Johnnie Walker
Can CH Redlion's
Bridlewold Shady Fourrest
This girl is a loving family member
with three small children and loves to swim and retrieve.
Print Pedigree
View Health info on the
OFA website
This litter will offer puppies
for show/breeding with great desire for basic field work and performance events.
sweet golden temperaments for family companions
Can CH Redlion's Bridlewold Lost In The Fourrest
OFA115559 Good, OFA EL35570 normal, OFA
EYE5047/2017-37, OFA CA29897 clear,
DM clear, PRA-1 clear,
PRA-2 clear, PRA-PRCD clear, Ichthyosis carrier
MBISS Am GCH/Can CH Pennylane
Yankee Renegade, OS
Can CH Redlion's
Bridlewold Shady Fourrest
"Lost" has a typical Golden personality
- sweet, enjoys playing endlessly, loves attention and the outdoors. She always
has something in her mouth to carry and she loves swimming and retrieving bumpers.
Lost boasts a great pedigree behind her and her puppies will offer very active,
talented, and trainable dogs. Lost has been in several show specialties and gotten placings in her class with 95+
golden entries. She has 5 show points (including a major) in the US and is a
Canadian show Champion including winning two Best of Breeds of champions.
12-27-16 Kitchener Ontario Canada Shows - "Lost" wins winners bitch/best of
winners all 4 shows and Best of Breed from the classes two shows to finish her
Canadian Show title.
12-23-17 "Lost" wins Winners Bitch & Best of Winners at Big Apple
Sporting Dog show for a 3 point major.
Print Pedigree
View Health info on the
OFA website
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Email Us
Jane Pappler, 7 Easton Way, Southampton, NJ, 08088 - 609 859-3570 -
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text: Bloodwitch Susan Dennard Ages 12+ Ebook PaperbackHardback Buy Audible eBooks.com Google Play iBooks Indie eBook Shop Kindle Kobo See more book details 10 January 2019 9781447288879 0 pages Synopsis Bloodwitch is the third book in the stunning Witchlands series by Susan Dennard, perfect for fans of Robin Hobb and Trudi Canavan.Loyalties will be tested as never before.The Raider King's plans to claim the Witchlands are underway. Now, his forces sow terror in the mountains, slaughtering innocents. After finding the slain, Aeduan and Iseult race for safety. And despite diverging goals, they've grown to trust one another in the fight to survive. Yet the Bloodwitch keeps a secret that could change everything. . .When Merik sacrifices himself to save his friends, he is captured by the Fury. However, Merik isn't one to give up easily, and he'll do whatever it takes to save those he loves. And in Marstok, Safi the Truthwitch agrees to help the empress uncover a rebellion. But those implicated are killed and Safi becomes desperate for freedom.War has come once more to the Witchlands. Perhaps if Safi and Iseult were united, their powers could bring peace. But chaos is not easily tamed. Truthwitch by Susan Dennard is like a cake stuffed full of your favorite fantasy treats: highway robbery, swordplay, deep friendships, treachery, magic, piracy on the high seas, and romance. If you like any or all of the above in the fantasy tales, this book will delight you Robin Hobb Truthwitch is an instant new classic. It reminded me of why I started reading fantasy in the first place: its fierce and vibrant world, richly-drawn characters, and dazzling intrigue harken to the best of Megan Whalen Turner, Robin Hobb, and Jacqueline Carey. And while it pays homage to the epic fantasies that have come before it, it also lays the foundation for a bright new chapter in the genre Sarah J. Maas Susan Dennard has worldbuilding after my own heart. It's so good it's intimidating Victoria Aveyard Books by Susan Dennard Windwitch Susan Dennard Paperback Truthwitch Susan Dennard Paperback Books in the The Witchlands Series series Truthwitch Susan Dennard Paperback Windwitch Susan Dennard Paperback Bloodwitch Susan Dennard Hardback Related blogs Science Fiction and Fantasy Guide to The Witchlands series 15/02/2019


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Houses for Tsunami affected will be distributed on Sep 29
Mysore, Sep 17 (UNI) As many 152 houses constructed by the Suttur Mutt, at Mudliarkuppan in Tamilnadu for those who have lost their houses in the devastating Tsunami in 2004 would be distributed on September 29.
In a press released issued here today it was stated that the Housing project for Tsunami displaced undertaken by the Suttur Mutt here has completed the work of constructing as many 152 houses at Mudliarkuppan in Tamilnadu and would be handed over to the affected on September 29.
The Mutt had constructed 92 houses earlier in its first phase at a cost of 225 lakhs and was distributed by Karnataka Chief Minister Mr H D Kumaraswamy in February 2006. The Karnataka Chief Minister also laid foundation stone for the second phase of housing project on the same day.
The mutt which took lead in providing housing facilities to those who lost their houses in the village in the devastating the tsunami had planned Rs 550 lakhs project to construct 244 houses and collected donations of Rs 225 lakhs from various mutts, industrialists, educational institutions, banks and philanthropies.
The state government also donated Rs 3.29 crores for the project.
Tamilnadu Chief Minister M Karunanidhi was expected to participate in the distribution of 152 houses in the II phase in which Karnataka Chief Minister Mr H D Kumaraswamy and other leaders from Karnataka also take part.
Seers Sri Shivarathri Deshkendra Swamiji, Pejawar Sri Vishwesha Theertha Swamiji and Ganapathi Sachghidananda Swamiji of Avadoota Datta Peeta would also grace the occasion the release added.


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Myrtle, Greystone's Newest Development, Surpasses 70 Percent Leasing at Lighting Fast Pace
April 19, 2017
Category: Corporate
Greystone Development announced that Myrtle, the first of a pair of luxury rental homes known as Myrtle & Steuben, is over 70 percent leased in less than two months. Dave Maundrell of Citi Habitats is exclusively leasing Myrtle and Steuben.
Myrtle features studio, one-, and two-bedroom units ranging from approximately 400 to 895 square feet, many with private outdoor space. Envisioned by AB Architekten, the building includes floor-to-ceiling double-glazed windows, with great light and air flowing into each unit and a fitness center offering soaring views of the Manhattan skyline. Other amenities include a rooftop terrace with lounge and BBQ area, virtual doorman, bike storage and laundry in each unit. Prices for available units start at $2,850.
The second phase of the development, Steuben, is located around the corner at 100 Steuben Street and will launch in the upcoming weeks. Steuben offers 43 residences consisting of studios to three bedrooms ranging from approximately 460 to 1,140 square feet. Steuben amenities will include a resident lounge, game room and co-working space as well as a fitness center, virtual doorman, rooftop terrace, bike and resident storage.
"We set out to create modern homes that pleasantly surprised local residents, effectively elevating the housing options in Clinton Hill. We harnessed AB Architekten's vision, which was a marriage of their signature minimalist style and cool palette of blues and grays to create a unique space that resonated with the local marketplace.
It has been such a huge success, and we are thrilled to have set new benchmarks for velocity of absorption in Clinton Hill," said Jeffrey Simpson, head of Greystone Development. "Clinton Hill is currently experiencing a residential renaissance, and we are excited to be contributing not only one, but two high-quality additions to this neighborhood."
Located on the resurgent Myrtle Avenue corridor of Clinton Hill, this prime location is within walking distance of several major public transportation routes. Additionally, the property boasts 9,000 square feet of retail space which has already attracted two premier retail tenants, European Wax Center and The Commissary Kitchen.
"Clinton Hill is quickly becoming a destination for residents, as the neighborhood's central location is extremely appealing to New Yorkers and its mix of independently-owned businesses immersed within the Pratt campus gives the area a true neighborhood feel," said Maundrell. "There is a very strong marketplace in NYC today for premium boutique properties like Myrtle & Steuben and when matched up with a location like we have, it's basically the best of both worlds."
For more information, visit www.myrtleandsteuben.com.


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I'm a young music blogger from Sydney, Australia who enjoys typing stuff up on a computer and pretending that she's actually connecting with people around the world.
I blog alternative and indie music, including new releases, weird songs, good songs and album reviews.
There's Songs of the Week (it sounds lame when you say it like that), Music Hauls, Cover Fests, Reeling Stones (movie reviews) and a bunch of random posts.
It would be wonderful (for both of us) if you could stop by and take a look at the blog.
So if you enjoy discovering new music, reliving old music or reading the blog posts of a lunatic, stop on by.
The link is here.
Also, if you are a blogger and interested in doing a collab or guest post, you can contact me at firstname.lastname@example.com.
Thanks for actually taking the time to read and get to this line. You rock, mate.


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Apple CEO Tim Cook highlighted a self-portrait created by 13-year-old Özgün Asya, who made the image on an iPad with Apple Pencil.
It's Children's Day in Turkey! 🇹🇷 Thanks to 13-year-old Özgün Asya from Istanbul for this colorful self-portrait, created on iPad using Apple Pencil. pic.twitter.com/N5EzH11F1x— Tim Cook (@tim_cook) April 23, 2018
Following the first video, Apple published six more short, 15-second clips where kids from Turkey explained the art that they created using iPad. Ali G. explained that he drew seven-and-a-half versions of himself due to his own age, Ece S. described her nature-focused portrait, and Defne A. showed off an image of her and her dog.
In the most recent video, shared over the weekend, Apple combined all of the self portrait videos into one 30-second ad.
The power of the iPad, the ease of use of Apple Pencil, and the unlimited creativity of children came together, and these extraordinary self-portraits came out.Apple's Children's Day videos showcase the latest 9.7-inch iPad, which was announced at an education-focused event in late March. The sixth-generation device includes Apple Pencil support with sensors that measure pressure and tilt so that users can take notes or illustrate in supported apps. The tablet has a reduced education price and multiple accessories that are particularly aimed at kids in school.
Discuss this article in our forums


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Complement your hosted environment with managed hosting services.
Under the Dedicated Server model, Clarity will be responsible for all hardware components on the server. Incorporating managed hosting services, will provide an additional layer of support for your server. We will manage the OS (Operating System) and monitor the system's health. Your server will be proactively updated to prevent attacks by patching vulnerabilities and monitored to mitigate outages. The single most important benefit for managed hosting is free upgrades for your Operating System (OS) version. Hardware is also upgraded at no extra cost if the OS is not supported on older technology. Under these circumstances, clients will benefit from updated equipment on faster platforms. Adding these services provide the most complete protection and support for your environment so that you can focus on your application and services.
Under the Virtualization solutions model, Clarity will manage the Virtual Infrastructure and is responsible for administration on Virtual Hosts. Adding managed hosting eliminates hardware and network overhead on your Virtual Infrastructure. Virtual Machine provisioning and decommissioning will be our responsibility. Allocating Virtual Machine resources and networking also falls under the managed hosting services profile. Clients can customize a redundant HA environment with Custom Solutions using backup and replication strategies. We take away the complex management of a Virtual environment so that you can focus on the individual Virtual Machines to effectively serve up the services for your applications.
Take a look at the following Hosting Services under the Managed Model:
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*Free Operating System Upgrades: Free hardware upgrade if newer architecture is needed for OS upgrade


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A Flow Chart for Success: Connecting Assessment to Instruction
by Fritz Geissler, M.Ed., and Donni Stickney, M.Ed.
Teachers throughout the nation are mandated to use research-based instructional strategies. According to the U.S. Department of Education (2004), No Child Left Behind (NCLB) emphasizes the implementation of educational programs and practices that have been scientifically researched and clearly yield high results. NCLB requires that educators use these research-based strategies as they are shown to aid students in learning and accessing the curriculum. Selecting the appropriate strategy to address each student concern is a crucial component to ensure student progress.
The first step in choosing an appropriate strategy is to clarify the student's needs through assessment. Pretests identify the student's prior knowledge and mastery of the necessary sub-skills in the curriculum. Classroom-based instructional assessments identify what students know, what they can do, and how they approach new material (Gravois & Gickling, 2002). A common mistake is to implement a research-based strategy that does not correctly match the student's need. An example would be using a strategy to increase a student's fluency by rereading passages and timing improvement (Instructional Consultation Teams: Training Manual, 2006, p. F8). However, if the underlying cause for poor fluency is a decoding deficit, the mistake could result in limited achievement gains for the student. This example highlights the importance of using assessments that will accurately inform instruction, target interventions, and monitor progress. Teachers effectively meet their students' needs through high-quality instruction that includes ongoing embedded assessment (see Figure 1).
After teachers have clarified the student concern and implemented an instructional strategy, the next step is to analyze the student's progress. When done correctly, this analysis provides the information necessary to determine the success of the strategy being used. Progress monitoring begins with collecting baseline data that shows where the student is performing prior to the intervention. Then short-term, intermediate, and long-term goals are developed. Data continues to be collected frequently to monitor student progress and to determine if the intervention is successful. An important component of this continuous assessment is providing the student with specific, corrective, and timely feedback regarding progress toward the goals (Marzano, Pickering, & Pollock, 2001). If the student makes expected gains, the strategy is continued until the goal is attained. However, if the student is not reaching goals, the teacher must determine if the instructional strategy has been implemented with fidelity. Next, the educator decides if additional assessment is required to ensure that the student concern has been correctly identified. If additional assessment concludes that the strategy does match the student concern, then the teacher may add additional strategies or increase the frequency with which the current strategy is being used. On the other hand, if assessment indicates a different student concern, then a new research-based strategy needs to be implemented. This continuous cycle of assessment, data collection, and analysis is crucial to determining proper instructional strategies and ensuring student success.
According to a study by Black and William (1998), low achievers benefit from the use of improved formative assessments more than other students. This reduces the range of achievement while raising achievement overall. Using formative assessments to guide classroom instruction has direct implications for districts seeking to reduce achievement gaps by students with disabilities and other subgroups targeted by NCLB (Chappuis, Stiggins, Arter & Chappuis, 2004). Assessment is no longer viewed as the narrow measurement process of aggregating scores for grading purposes, or for comparing one student to another across different intellectual and achievement domains. Instead, it is viewed as a means of determining how a student is actually learning and thinking about what is being taught. Assessment is about asking relevant questions and gathering relevant data to identify what a student knows and needs, and about matching and managing curriculum and instruction to ensure ongoing student success (Instructional Consultation Teams: Training Manual, 2006, p. 12).
Black, P., & William, D. (1998). Inside the black box: Raising
standards through classroom assessment. Phi Delta Kappan, 80(2),
Chappuis, S., Stiggins, R.J., Arter, J., & Chappuis, J. (2004). Assessment for learning: An action guide for school leaders. Portland, OR: Assessment Training Institute.
Gravois,T., & Gickling, E. (2002). Best practices in curriculum-based assessment. In A.Thomas & J. Grimes (Eds.), Best practices in school psychology (pp.1-13). Washington, DC: National Association of School Psychologists.
Instructional Consultation Teams: Training manual. (2006). College Park, MD: Instructional Consultation Labs.
Marzano, R.J., Pickering, D.J., & Pollock, J.E. (2001). Classroom instruction that works: Research-based strategies for increasing student achievement. Alexandria, VA: Association for Supervision and Curriculum Development.
U.S. Department of Education. (2004). No Child Left Behind: A toolkit for teachers. Jessup, MD: Education Publications Center.
Additional Resources
Instructional Assessment: An Essential Tool for Designing Effective Instruction (Considerations Packet) may be requested from the T/TAC website at http://www.wm.edu/ttac/packets/consideration.html.
The Forgotten Art of Formative Assessment, by Christopher R. Gareis, Ed. D. February/March 2006, T/TAC Newsletter, http://www.wm.edu/ttac/corner/2006febmar.html.


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Case 5
Joseph Coleman & Richard Luckett v. Clive Barker, Trans Atlantic Films, Fifth Avenue Productions, Paramount Pictures, Nostradamas Pictures, & Miramax Films
U.S. District Court, Southern District of New York – May 10, 1993 (Case No. 93 Civ 3127)
The case was dismissed upon filing a notice of dismissal prior to service of defendant's answer or motion for summary judgment.
On May 10, 1993, Gale Elston, attorney for plaintiffs Coleman and Luckett, brought an action in the USDC, Southern District of NY, against defendants Nostradamas Pictures, Trans Atlantic pictures, Miramax Films, Paramount Pictures, Fifth Avenue Productions, and Clive Barker for copyright infringement of Coleman's artwork "Portrait of Professor Mombozoo" in the film Clive Barker's Hellraiser III: Hell on Earth. Plaintiff alleged also breach of Luckett's contract rights set forth in an agreement dated 9.24.91. Particularly, it occurred that defendants have failed to perform the conditions on the contract by failing to give Luckett on-screen Consultation Credit in Clive Barker's movie. Copyright infringement occurred with the release of the film on 11.1.1992. In light of the release of the home video version of the film, Plaintiff sought in the same action a temporary restraining order.
Plaintiff Coleman is a significant is a significant original artist with a national and international following whose reputation in the art world was seriously damaged by the release of the film with the reproduction of his famous "The portrait of Professor Momboozoo"Plaintiff sought damages and injunctive relief that would require defendants to refrain from producing, marketing, distributing or selling or otherwise disposing of any copies of Clieve Barker's Hellraiser III.OutcomeThe case was voluntary dismissed with prejudice because a Plaintiff filed a notice of dismissal. The Court granted the motion on October 12, 1993.
Nature of the Suit: Property Rights - Copyright; Contract Rights
Key Nature of the Suit: Intellectual Property; Copyright; Contract Law
Cause: 17 USC 501


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**** PM O'Neill Blasts Namah for Interference Following Supreme Court Decision on Regional Processing Centre, Interference Could Lead to More Deaths at Sea ****
May 16, 2016
The Prime Minister, Hon. Peter O'Neill CMG MP, has called on Belden Namah to stop grandstanding over the Supreme Court Decision on the Manus Regional Processing Centre, and to let the governments of Papua New Guinea and Australia go about getting on with the process of adhering to court orders.
"Closure of the Centre will require co-ordinate effort and our officials from both countries are working on this at the moment," PM O'Neill said.
"Just standing on a soapbox and beating your chest does nothing to change the processes involved in adhering to this decision.
"The centre will not close overnight as it is a significant scale of operation and this process has to be done properly.
"The essential part in all of this is the adhere to the decision of the court in a timeframe that is acceptable to the court.
"Belden Namah should focus on his own legal issues before trying to tell anyone else how to interpret court decisions."
The Prime MInister was scathing over the risk Belden Namah's comments had at stimulating further people trafficking which could only lead to additional loss of life.
"Namah's grandstanding is going to play right into the hands of people smugglers and will be the trigger for more deaths at sea.
"He has to try and understand the complexities of this issue.
"The people smugglers take news stories from people like Nama to try and convince families to attempt to travel to Australia, and because of this many children, women and men will die.
"Ultimately the people smugglers will use Namah's words to suggest that trafficking routes are open, which of course is not true.
"Papua New Guinea played an important role in preventing deaths at sea at the hands of people smugglers, we can be proud that we have been part of this international operation that has saved lives."
Prime Minister O'Neill said discussion was ongoing between officials from Papua New Guinea and Australia, and further announcements would be made at the appropriate time.


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Join hosts Mike and Didi as they bring you news and discussion about everything fun, including theme parks, video games, television, movies, music and more. [Read more…]
Free PlayStation My Road To Greatness tour stops in Orlando November 5
Video game fans can glimpse the future of PlayStation for free during the My Road to Greatness tour stop
at The Plaza Live in Orlando on November 5. [Read more…]


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Most already know the story of Abraham-Louis Breguet's ascension to watchmaking royalty whilst delivering timepieces to actual royalty. Somewhat less told is Breguet's delivery of flyback chronographs to the French air force (the foundation for the current Type XX, XXI & XXII collections) or his work with marine chronometers for their naval forces. The marine chronometers are of particular importance as they would be relied upon in harsh conditions to keep near perfect timing. Released in the early 1990's, the current Marine family from Breguet bear the traits of their forefathers but with lovely modern twists.
The entry level model, if it can be described as such, for this family is the automatic version with oversized date at 6 o'clock. The 39mm steel case is perhaps not quite as large as its peers but offers a nice solid case fit for purpose with a sapphire glass caseback to showcase Breguet's well finished automatic movement. THe guilloche dials carry an evocative but subtle pattern while an oversize date window at 6 o'clock marries pretty with practical. All the Marine family enjoy the tubular finish to the side of the case. It is this extra detail that Breguet originally innovated moving a new technology at the time from the realm of offering functionality to also being a piece of art in itself. The steel model on rubber strap begins at £11,100.00 and is also offered in gold.
Next up in the collection is perhaps the most popular too; the Marine Chronograph. Within the last two years, the exact layout of the chronograph totalisers has become more asymmetric but the overall balance of the watch is not affected. The quality and feel of the flyback chronograph is as one would expect from a brand like Breguet and the case is specifically made to feel weighty so the owner can feel the substance. One of my personal favourite elements within this family is the rubber strap. Too often, the designers place so much emphasis on the case and dial, the straps become an afterthought, especially when rubber is concerned.
Breguet have chosen to pattern the rubber strap giving it a depth and character all of its own. Add that to a very very solid gold folding clasp, also exquisitely finished…one has a very well thought out high end sports watch at a very competitive price point given who we would consider to be Breguet's competition. This particular version retails at £22,500.00 but is also available in White Gold & now Platinum too. Each of the Marine Chronograph models carries a spare alligator strap as standard.
The latest addition in terms of complication to the Marine collection is the Dual Time model. Fulfilled in Rose Gold or steel as shown here, the sub dial at 6 o'clock acts as either a second timezone or home time if you prefer with the user able to manipulate the main hour hand alone. The sub dial at 2 o'clock is a 24 hour counter confirming whether it is AM or PM on your second time whichever way you choose to set it up. At 42mm, the case is larger in width & depth than the previous two models but does not necessarily feel oversized. The one area I cannot praise highly enough is the dial. As one would expect from Breguet, the dial is finished to level not even attempted by most brands but in this case, even the 24 hour register has been detailed not just differently to the main dial but in two formats to help the reader assess day & night easily! a quite frankly astound tool watch for the seasoned traveller. £16,900.00 in steel…
The Marine Royale is a strange fit in what is a sporty but ultimately elegant family of watches. At 46mm, it is a big, big watch but also being only delivered in precious metal, it is also a substantial timepiece. The unidirectional bezel is quite rugged and the various pushers only add to the overall heavy weight impression! The additional complication here is a mechanical & waterproof alarm feature that like the flagship Reveil du tsar model, can be turned on & off via the large button at 8 o'clock. The screw down crowns at 2 & 4 o'clock manage the date, time & setting the alarm hand. Though the actual watch is automatic, the alarm is powered by a hand wound barrel whose power reserve is indicated on the dial at 11 o'clock. Now…given how many crowns, buttons & indicators are involved, it still remain a reasonably clean & very legible timepiece.
The mixture of brushed & polished edges have been carefully devised while the alarm gives a solid sonorous sound whilst also reverberating throughout the case so the user can feel the buzz underwater if required. I personally feel this model sits a little ill at ease with the rest of the collection, which are fundamentally quite elegant in size, even the fully gem set models. That said, as a modern sports model…the size is totally in keeping with the trend for larger watches, and Breguet's level of finishing speaks for itself as well as the very cool rubber strap. The Marine Royale in Rose Gold retails at £33,100.00 but is also available in White Gold.
Finally, what Breguet collection would be complete without his eponymous Tourbillon! When I began working with Breguet, this was definitely my grail watch from this brand. Tourbillon's had yet to become the mainstream complication that they are now, especially within a sports medium. This model is simply beautiful…42mm in diameter with a suspended Tourbillon carriage at 12 o'clock. The detailing to the case is as I have described above but out of all the Marine family, this is by far my favourite as seeing the Tourbillon oscillating away is a very emotive experience. Retailing at £113,800.00 in Rose Gold, it is not cheap by any means but should you choose to purchase a model of this nature, you would definitely not be disappointed by the Breguet Marine Tourbillon Chronograph.
New Cavendish Jewellers has been an official partner for Breguet for over a decade now, please feel free to visit our Boutique or contact us for further details.


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News Release
to Perform at Evergreen House
Third Concert of 2006-2007 Season
The Evergreen Concert Series — one of Baltimore's longest-running chamber music programs — continues with the Adaskin String Trio and guest oboist Thomas Gallant at 8 p.m. on Friday, March 23. The musicians will perform Druschetzky's Quartet in G Minor for oboe and strings, Beethoven's String Trio in D Major, Taneyev's String Trio in B Minor, and Mozart's Quartet for oboe and strings in F Major. This will be the first appearance of this internationally-recognized ensemble on Evergreen's concert series. The performance, to be held in Evergreen's Bakst Theatre at 4545 N. Charles St. in Baltimore, will be followed by a reception with the musicians. Tickets are $15 for members and $20 for non-members; $5 student rush tickets will be available one hour prior to performance (limit two tickets per valid student ID). Due to limited seating, reservations are recommended. Advance tickets can be obtained by visiting this Web site: www.missiontix.com; or by calling 410-516-0341. Complete concert information is available online at www.jhu.edu/evrgreen/concerts.
The Adaskin String Trio, praised by WGBH-Boston for having "stretched the musical boundaries of what is possible," is the premiere ensemble of its kind in North America. Founded in 1994, the trio has performed extensively throughout Canada and the United States. They have become renowned for their interpretations of a vast repertoire ranging from works by Haydn, Mozart, Beethoven, and Schubert, to rarely-heard treasures by 20th-century giants such as Heitor Villa-Lobos and Alfred Schnittke. Their commanding performances of string trios by Sergei Taneiev, Lennox Berkeley, and Miklós Rózsa have been revelations to both novice and seasoned chamber music enthusiasts. The trio also has numerous premieres to its credit, including works by Murray Adaskin and Robert Carl (recipient of both the Charles Ives and Aaron Copland Fellowships). In 1998 the Adaskin String Trio was a finalist for the prestigious Walter W. Naumburg Foundation chamber music award in New York. The trio's concerts have been recorded for CBC Radio, Radio-Canada (CBC's French- language counterpart) and National Public Radio. In 2003 they released on the Musica Omnia label a recording of the complete string trios of Beethoven, described by American Record Guide as "masterly." Future recording projects include works by Haydn, Carl and Fauré. They also have commissioned works by Raymond Luedeke and Ana Sokolovic for a special collaboration with accordion virtuoso Joseph Petric. Publicity photos may be found online at www.adaskinstringtrio.com.
Virtuoso oboist Thomas Gallant, praised by the New Yorker magazine as "a player who unites technical mastery with intentness, charm and wit," is a First Prize Winner of the Concert Artists Guild International New York Competition. He has performed as both soloist and chamber musician in prestigious halls around the world with such artists as Jean-Pierre Rampal and the Kronos Quartet. After studying at the Indiana University School of Music, he performed with the New Orleans Symphony and the Santa Fe Opera Orchestra. Known for his unique performance style, which combines the American and European traditions of oboe playing, Gallant plays on an "Evoluzione" oboe made by the Italian maker Fratelli Patricola.
Evergreen is at once an intimate collection of fine and decorative art and a vibrant, innovative venue for contemporary artists, musicians and scholars. Since 1952, the museum's concert series has presented over 200 performances by renowned musicians and outstanding emerging artists in Evergreen's intimate Bakst Theatre — designed by avant-garde Russian-born artist Léon Bakst — and in its 1870s Carriage House. Audiences mingle with performers at a post-concert reception and enjoy a shared experience they won't find anywhere else.
Funded in large part by the Evergreen House Foundation, Evergreen's chamber music program continues Alice Warder Garrett's legacy of supporting established and emerging musicians, and inviting audiences to interact with them.
The final concert this season is:
Classical and cool. Cellist prodigy Matt Haimovitz is one of classical music's most adventurous artists, with a repertoire spanning from J.S. Bach to Led Zeppelin. The program, including György Ligeti's Sonata for Violoncello Solo and selections from J.S. Bach's Suites for solo cello and Ned Rorem's After reading Shakespeare: suite in 9 movements for cello solo, will speak to music enthusiasts of every persuasion. This not-to-be-missed concert will be held at the Carriage House.
Go to Headlines@HopkinsHome Page


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Flat and Low Slope Florida Roofs
Reliant Roofing, Inc. is a commercial and industrial roofing specialist committed to providing quality roofing in Jacksonville, Florida. Behind every quality roofing service, whether it is re-roofing, new construction, or roof coating systems, Reliant Roofing, Inc. strives to provide excellence in commercial roofing solutions. Reliant Roofing, Inc. pledge is to offer the highest quality in commercial roofing production standards, timely performance, along with providing the knowledge and resources necessary to achieve the appropriate and most cost-effective roofing solutions possible.
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Working at PRMR Inc., I have come to love the work that I do for the first time. Not only do I want to come to work in the morning but also I actually wake early enough to make breakfast and eat it before leaving home. This has never happened before.
PRMR Inc. Communications Blog
Topics: love what you do, Bridgetown, blog, barbados, Perspectives, love for my job
Organizations should strive to have a culture that embraces change. This is important so that when change comes, as it always does, employees would not sabotage the organization because they already operate in a culture that is dynamic. In situations like mergers and acquisitions for example, managers can be sure that employees would be less resistant and would make a smooth transition into new cultures and territories if the culture already promotes development.
Topics: Bridgetown, blog, sharing information, barbados, Perspectives, organization culture
A serious sports enthusiast, I was an Olympic Games junkie. I sat for hours in front of the television and watched sport after sport, living vicariously through the athletes. Appreciating fully the sacrifice, dedication and discipline that each athlete at the games had to endure to reach, let alone medal in the games.
Topics: Perspectives
There was a show on television which highlighted the fact that humans respond to what they think they are going to hear without even listening to the question. They gave a series of questions. All of the participants in the surveyed failed at answering the questions, including me, the at home participant.
Topics: Bridgetown, blog, effective listening skills, listening, barbados, Perspectives


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SmartMud® No Mess Mud Detox Sheet Mask - Single Sachet
Rid your skin of impurities in one clean step with SmartMud® No Mess Mud Masques. They make mud easy to apply and remove. It's the neatest way to clear up your complexion and dispose of pore-clogging debris.
Our mineral-rich volcanic ash removes impurities and renews your skin's clarity. Sourced from Jeju Island in South Korea, it also helps tighten pores so they appear less visible. You're left with a youthful glow that's healthy and debris-free.
How to Use
Our SmartMud No Mess Mud Masque comes in two pieces (one for the upper portion of your face and one for the lower). Detoxifying but never drying, our mud masque should be used once a week or as often as needed.
Step 1: Unfold both sections.
Step 2: Remove the white backing and place mud mask over face.
Step 3: Remove the clear backing and press snugly into facial contours.
Step 4: Leave on for 10 minutes or longer if desired.
Step 5: Remove, discard masque and rinse with warm water.
Water (Aqua), Kaolin, Butylene Glycol, Bentonite, Polysorbate 80, Glycerin, Magnesium Aluminum Silicate, Volcanic Ash, Stearic Acid, Xanthan Gum, Mica, Bismuth Oxychloride, Iron Oxides, Charcoal Powder, Hydrolyzed Collagen, Allantoin, Panthenol, Portulaca Oleracea Extract, Morus Alba Leaf Extract, Morus Alba Fruit Extract, Phenoxyethanol, Tromethamine, Dipotassium Glycyrrhizate, Disodium EDTA, Methylparaben, Fragrance (Parfum)


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'Jet Pass' product design for new and existing vehicles are differentiated from Dash Cams and all the other "new avoidance technology" because they focus on eliminating everyday road hazards and accident prevention.
"Jet Pass System"
The Jet Pass System which is a Life Saving, Accident Prevention Car Safety System that dramatically reduces the exposure to the following daily hazards:
Avoid the frustration of trying to pass when your view is obstructed by a group of slow moving vehicles.
Pulling or backing out of parking spaces, garages or driveways into a roadway when your view is impaired.
Who hasn't experienced the fear and anxiety of backing out blindly from a parking space or driveway!
There are three systems available for Trucks, buses and heavy commercial vehicles :
A: Basic 2 camera unit provides: visibility of vehicles in oncoming and peripheral lanes when attempting to pass.
B:The ultra 4 camera unit provides visibility when passing and Pulling or backing out of parking spaces, garages or driveways into a roadway when your view is impaired.
C: The deluxe system has four cameras, two on the mirrors and two on the rear bumper that allows drivers to see approaching vehicles on both sides when entering intersections, backing up or pulling out of parking spaces or driveways.
We focus on eliminating obstructed views because most major accidents occurring while passing. Exterior mounted cameras connected to a split screen monitor mounted the dashboard displays blind spots.
Imagine the life and cost saving from this disruptive safety system from reduced: Claims; law suits; legal defense fees; Doctor's fees; long & short term medical cost; claims staff; claims investigators; damage to surrounding property, loss of productivity etc.
50% of all accidents involve parking!
Twenty five percent of all parking lot accidents are caused by vehicles backing up.
The Vehicle Safety System is a revolutionary patented system for large trucks, buses and vans which often find themselves trapped and blinded behind a line of large vehicles. Also, they do not have the maneuverability to pull out of their lane to see and return without exposing themselves to head-on collisions with oncoming vehicles.
Tosheka Products Introduces our Jet Pass Accident Prevention Systems with Fleet Monitoring and Management Capability


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A team of researchers, led by Serge Przedborski, at Columbia University in New York, have demonstrated that infusion of D-beta-hydroxybutyrate (D-beta-HB) to mice suffering from Parkinson disease restored impaired brain function and protected against neurodegeneration and motor skill abnormalities. D-beta-HB, already utilized in the treatment of epilepsy, may represent a cheap and easy way to treat Parkinson disease.
Parkinson disease is the second most common neurodegenerative disorder after Alzheimer disease. Sufferers experience motor skill abnormalities including tremor, muscle stiffness, and unstable voluntary movements and posture. The main pathological feature of the Parkinson brain is the loss of dopaminergic neurons.
Reported in an article in the September 15 issue of the Journal of Clinical Investigation, Przedborski and colleagues administered the neurotoxin MPTP to mice, which caused dopaminergic neurodegeneration and deficits in the mitochondrial electron transport chain reminiscent of Parkinson disease. Using this model of disease, the authors showed that the infusion of the ketone body D-beta-HB restored mitochondrial respiration and protected against MPTP-induced neurodegeneration and motor deficits. The study supports a critical role for mitochondrial defect in Parkinson disease.
Ketone bodies are already successfully used in the treatment of epilepsy. They are also able to penetrate the blood-brain barrier that often prevents potentially beneficial drugs from entering the brain.
D-beta-HB may therefore be considered as a novel form of neuroprotective therapy in the treatment of Parksinson disease.
TITLE: D-beta-Hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson disease
Serge Przedborski
Columbia University, New York, New York, USA.
Phone: (212) 305-1540
Fax: (212) 305-5450
E-mail: firstname.lastname@example.com
View the PDF of this article at: https:/
T cell lifespan during HIV infection
Scientists have long held the prevailing view that during HIV infection the depletion of T cells is the result of direct HIV virus-mediated killing. In the September 15 issue of the Journal of Clinical Investigation, Marc Hellerstein and colleagues at the University of California in Berkeley report that it is the chronic activation of the host immune system in response to HIV infection that primarily contributes to T cell loss.
A series of influential studies published in the mid-1990s described the rapid decay of viral load following administration of highly active antiretroviral therapy (HAART), and proposed that HIV infection was associated with a high rate of virus turnover and short lifespan of infected cells. This suggested that HIV infection of susceptible CD4+ T cells led to such high rates of cell death, that compensatory T cell proliferation was inadequate to maintain sufficient T cell numbers and therefore compromised the ability of the immune system to fight the virus.
This view was recently challenged by observations that not only were virus-infected cells dying, but a greater number of uninfected bystander T cells underwent programmed cell death that was not a direct result of HIV infection. Therefore, a new theory has been proposed in which high levels of T cell proliferation reflects a state of chronic immune activation following HIV infection as opposed to simple compensatory proliferation.
Hellerstein and colleagues used a highly innovative technique for measuring the dynamics of T cell turnover in 3 groups of individuals: (i) HIV-infected; (ii) HIV-infected HAART-treated; and (iii) uninfected. They authors found that most of the increased T cell turnover during HIV infection involved a subset of memory T cells - those cells which have encountered prior infection and can rapidly mobilize and clone themselves should the same foreign antigen be encountered during a subsequent infection. The authors concluded that the increased degree of proliferation of this T cell subset was the result of chronic immune activation and not the result of a mechanism striving to compensate for the loss of T cells directly killed by the virus. The increased degree of memory T cell turnover results in a lack of long-lived memory T cells available to assist newly infected cells. The authors did however demonstrate that HAART was able to ameliorate the defect in the production of these long-lived cells.
This identification of this fast-replicating but short-lived subset of T cells aids our understanding of how the body reacts to HIV infection and how HIV wields its destructive power. In an accompanying commentary Guido Silvestri and Mark Feinberg from the Emory Vaccine Center in Atlanta, Georgia, discuss how the dynamics of the T cell population effects the progression of HIV disease. These authors add that the present study "provides important clues as to how HIV infection leads to CD4+ T cell depletion and AIDS". It is still not clear how HIV induces this chronic state of immune activation and why this is so disruptive to the proper overall functioning of the host immune system. Silvestri and Feinberg continue, "some of these questions can be resolved with future application of the innovative and informative labeling techniques pioneered by Hellerstein and colleagues".
TITLE: Subpopulations of long-lived and short-lived T cells in advanced HIV-1 infection
Marc Hellerstein
University of California, Berkeley, California, USA.
Phone: (510) 642-0646
Fax: (510) 642-0535
E-mail: firstname.lastname@example.com
View the PDF of this article at: https:/
Turnover of lymphocytes and conceptual paradigms in HIV infection
Mark B. Feinberg
Emory Vaccine Center, Atlanta, Georgia, USA.
Phone: (404) 727-4374
Fax: (404) 727-8199
E-mail: firstname.lastname@example.com
View the PDF of this commentary at: https:/
BMPs and bone loss: get it through your noggin
A study by Etsuko Abe and colleagues at Mount Sinai School of Medicine in New York has revealed that the balance between the expression of the bone-building protein BMP, and the BMP inhibitor noggin, plays a crucial role in regulating bone formation and loss. The overproduction of noggin may ultimately result in the net bone loss associated with conditions such as osteoporosis. The study suggests that recombinant BMP may prove useful in reversing age-related bone loss.
Bone morphogenetic proteins (BMPs) 2 and 4 are known to regulate hair follicle growth and skeletal development. These effects are inhibited by a protein called noggin, yet little was known about the role of noggin in the differentiation of bone-building cells (osteoblasts) and adult skeletal remodeling. In an article in the September 15 issue of the Journal of Clinical Investigation, Abe and colleagues have found that noggin is expressed in osteoblasts, chondrocytes, and macrophages. Infection of preosteoblastic cells with a retrovirus containing noggin inhibited osteoblast differentiation. A transgenic mouse that overexpressed noggin in mature osteoblasts displayed dramatic osteoporosis, decreased trabecular and calvarial bone, diminished bone formation rates, and reduced osteoblast differentiation.
These studies provide strong evidence that the balance between the expression of BMPs and noggin may determine the extent of bone building and breakdown, and ultimately bone mass in adult mice. The overproduction of noggin during aging may result in impaired bone building and function and hence, net bone loss.
Following the recent FDA approval of recombinant BMP2 for specific uses, there remains great clinical interest in the role of BMPs and noggin in the regulation of bone formation and repair in a variety of conditions, including osteoporosis. Abe and colleagues suggest that recombinant BMP may prove useful in reversing age-related bone loss.
TITLE: Impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis in noggin-overexpressing mice
Etsuko Abe
Mount Sinai School of Medicine, New York, New York, USA.
Phone: (212) 241-8735
Fax: (212) 534-4820
E-mail: email@example.com
View the PDF of this article at: https:/
Tracking autoimmune T cells in diabetes
Insulin-dependent diabetes mellitus is usually caused by autoimmune destruction of pancreatic beta cells by T cells. Methodologies to track the development, migration, and functional activation of one class of such T cells (CD4 T cells) have been limited. This is an important issue for studies designed to monitor the efficacy of potential intervention protocols. Luc Teyton and colleagues at The Scripps Research Institute in California, introduce an exciting new tetramer technology that allows a particular set of diabetogenic CD4 T cells to be quantified and tracked.
In an accompanying commentary, Edward Leiter from The Jackson Laboratory in Bar Harbor, Maine, discusses the potential uses of this technology that may help researchers design appropriate intervention protocols that may inhibit progression to overt insulin-dependent diabetes in humans at risk for this debilitating disease.
TITLE: Susceptible MHC alleles, not background genes, select an autoimmune T cell reactivity
Luc Teyton
The Scripps Research Institute, La Jolla, California, USA.
Phone: (858) 784-2728
Fax: (858) 784-8166
E-mail: email@example.com
View the PDF of this article at: https:/
Tracking autoimmune T cells in diabetes
Edward H. Leiter
Jackson Laboratory, Bar Harbor, Maine, USA.
Phone: (207) 288-6370
Fax: (207) 288-6079
E-mail: email@example.com
View the PDF of this commentary at: https:/
Antioxidants play a crucial role in estrogen-deficiency bone loss
Osteoporosis is an enormous clinical problem, yet the mechanisms through which estrogen-deficiency causes bone hyper-resorption remain controversial. A report by Timothy Chambers and colleagues at St. George's Hospital Medical School, London, may resolve these controversies by demonstrating that estrogen-deficiency sensitizes cells to oxidant signaling and stress by lowering thiol antioxidants in bone resorbing cells. This mechanism provides novel opportunities for the development of potential osteoporosis therapies.
TITLE: A crucial role for thiol antioxidants in estrogen-deficiency bone loss
Timothy J. Chambers
St. George's Hospital Medical School, London, United Kingdom
Phone: 44-20-8725-5270
Fax: 44-20-8725-0064
E-mail: email@example.com
View the PDF of this article at: https:/
Cancer and Trousseau syndrome: the missing link revealed
Ajit Varki and colleagues from the University of California, San Diego, have revealed why individuals presenting with Trousseau syndrome also mysteriously suffer from mucin-producing carcinomas and why the anti-clotting agent heparin, but not other antithrombotic agents, is capable of ameliorating Trousseau syndrome.
Trousseau syndrome involves the formation of platelet-rich aggregates (microthrombi) in small blood vessels, in individuals with mucin-rich adenocarcinomas. However, no molecular link between carcinoma mucins and thrombosis previously existed. Adenocarcinomas secrete abnormally glycosylated mucins into the bloodstream that present pathological binding sites for P- and L-selectins.
Hypothesizing that selectin interactions with circulating mucins might trigger the syndrome, Varki and colleagues injected purified carcinoma mucin preparations into mice, rapidly inducing platelet-rich microthrombi. These were diminished in P- and L-selectin-deficient mice and by the anticoagulant heparin. Inhibition of endogenous thrombin did not block platelet aggregation. The authors therefore deduced that Trousseau syndrome is likely triggered by interactions of circulating carcinoma mucins with leukocyte L-selectin and platelet P-selectin without requiring accompanying thrombin generation. The authors also suggest that heparin was likely working by directly inhibiting P- and L-selectin interactions. This may also explain why Trousseau syndrome is ameliorated by heparin but not by other antithrombotic agents.
TITLE: Selectin-mucin interactions as a probable molecular explanation for the association of Trousseau syndrome with mucinous adenocarcinomas
Ajit Varki
University of California, San Diego, La Jolla, California, USA.
Phone: (858) 534-2214
Fax: (858) 534-5611
E-mail: email@example.com
View the PDF of this article at: https:/
Tracking T cells in Hepatitis C
The characterization of CD4 T cells populations specific for microbial antigens or self-proteins represents a major challenge in human immunology. The characterization of these populations is relevant to the outcome of chronic viral infections, such a Hepatitis C. Kai Wucherpfennig and colleagues at the Dana-Farber Cancer Institute in Boston, Massachusetts, have created fully functional MHC class II molecules for tetramer-based analysis of T cell populations. Using these MHC class II tetramers the authors were able to characterize CD4 T cell populations present at very low frequencies in subjects infected with Hepatitis C virus (HCV). The authors demonstrate that HCV-specific CD4 T cells can be isolated from subjects who resolved viremia, but not in patients suffering from chronic progressive infection, and that these T cells have a distinctive memory phenotype. This technique affords researchers the ability to study rare populations of memory CD4 T cells in human diseases.
TITLE: Ex vivo analysis of human memory CD4 T cells specific for hepatitis C virus using MHC class II tetramers
Kai W. Wucherpfennig
Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Phone (617) 632-3086
Fax: (617) 632-2662
E-mail: email@example.com
View the PDF of this commentary at: https:/
Liver enzyme, PKC-lambda, mediates insulin sensitivity
Individuals with type 2 diabetes often exhibit impairment of insulin action in the liver. Masato Kasuga and colleagues at Kobe University, Japan, have found that mice deficient in the hepatic enzyme PKC-lambda have increased overall insulin sensitivity, yet their blood glucose concentration remained within normal limits. The authors demonstrated a link between the altered expression of the sterol regulatory element-binding protein SREBP-1c gene and its target genes, and defective PKC-lambda signaling. Restoration of PKCl expression in the liver restored SREBP-1c expression and insulin sensitivity to normal. This study suggests that reagents that block PKC-lambda signaling specifically in the liver might consequently ameliorate insulin resistance.
TITLE: PKC-lambda in liver mediates insulin-induced SREBP-1c expression and determines both hepatic liver content and overall insulin sensitivity
Masato Kasuga
Division of Diabetes and Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe, Japan.
Phone: 81-78-382-5861
Fax: 81-78-382-2080
E-mail: firstname.lastname@example.com
View the PDF of this article at: https:/
HATs off to Hop in cardiac hypertrophy
Histone acetylation, regulated by two antagonistic enzymes - histone acetyltransferases (HATs) and histone deacetylases (HDACs) - results in transcriptional changes and also plays a critical role in cardiac development and disease. A new study by Jonathan Epstein and colleagues from the University of Pennsylvania shows that overexpression of the atypical transcriptional co-repressor homeodomain-only protein (Hop) causes cardiac hypertrophy via recruitment of a class I HDAC. In contrast to the body of work on transcriptional mechanisms that drive cardiac hypertrophy, including class II HDACs, this report elucidates a novel growth-suppressing transcriptional pathway in cardiac muscle that opposes hypertrophic growth.
In an accompanying commentary, Yasuo Hamamori and Michael Schneider from Baylor College of Medicine in Houston, Texas, further discuss the roles of HDACs and Hop in cardiac hypertrophy.
TITLE: Cardiac hypertrophy and histone deacetylase-dependent transcriptional repression mediated by the atypical homeodomain protein Hop
Jonathan A. Epstein
University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Phone: (215) 898-8731
Fax: (215) 573-2094
E-mail: firstname.lastname@example.com
View the PDF of this article at: https:/
ACCOMPANYING COMMENTARY HATs off to HOP: recruitment of a class I histone deacetylase incriminates a novel transcriptional pathway that opposes cardiac hypertrophy
Michael D. Schneider
Center for Cardiovascular Development, Baylor College of Medicine, Houston, Texas, USA.
Phone: (713) 798-6683
Fax: (713) 798-7437
E-mail: email@example.com
View the PDF of this commentary at: https:/
Activation of adenosine receptors protects the kidney
Mark Okusa and colleagues from the University of Virginia have investigated the contribution of A2A adenosine receptors expressed on bone marrow--derived cells to the protection of renal tissue against ischemia-reperfusion injury (IRI). The authors determined that activation of these receptors expressed on bone marrow--derived cells is necessary for tissue protection in a mouse model of IRI.
TITLE: Renal protection from ischemia mediated by A2A adenosine receptors on bone marrow-derived cells
Mark D. Okusa
University of Virginia Health Sciences Center, Charlottesville, Virginia, USA.
Phone: (434) 924-2187
Fax: (434) 924-5848
E-mail: firstname.lastname@example.com
View the PDF of this article at: https:/
CD69 and TGF-beta: double trouble in arthritis
Francisco Sánchez-Madrid and colleagues from Hospital de La Princesa in Madrid, Spain explored the role of the cytokine CD69 in a mouse model of collagen-induced arthritis (CIA). Their results strongly suggest that CD69 is a negative regulator of autoimmune reactivity and agonistic anti-CD69 antibodies may be useful in the treatment of chronic inflammation in diseases such as arthritis.
The CD69 receptor is induced following activation of leukocytes at inflammatory sites, but its physiological role during inflammation remains unknown. Sánchez-Madrid and colleagues explored the role of CD69 in autoimmune reactivity by analyzing a model of CIA in CD69-deficient mice. CD69-/- mice showed increased CIA, with exacerbated T and B cell immune responses to type II collagen. Transforming growth factor (TGF) -beta1 and TGF- beta2, which are protective in CIA, were reduced in the inflamed joints of CD69-/- mice, correlating with the increase in other proinflammatory cytokines. Local injection of blocking anti-TGF-beta antibodies increased CIA severity and proinflammatory cytokines in control but not CD69-/- mice. These results show that CD69 is a negative modulator of autoimmune reactivity and inflammation through synthesis of TGF-beta, a cytokine that in turn downregulates the production of various proinflammatory mediators.
TITLE: CD69 downregulates autoimmune reactivity through active transforming growth factor-beta production in collagen-induced arthritis
Francisco Sánchez-Madrid
Hospital de La Princesa, Madrid, Spain.
Phone: 34-91-5202370
Fax: 34-91-5202374
E-mail: email@example.com
View the PDF of this article at: https:/
15d-PGJ2 revealed as imposter PPAR-gamma ligand
Over the past several years there has been increasing interest in the prostaglandin D2-derived product 15d-PGJ2. In 1995, evidence was reported that suggested that 15d-PGJ2 was capable of activating the transcription factor PPAR-gamma. At the time, the finding was of considerable interest because the endogenous ligand for PPAR-gamma was unknown. Since then, 15d-PGJ2 has often been referred to as the endogenous PPAR-gamma ligand. Garrett FitzGerald and colleagues at the University of Pennsylvania used a highly sensitive and specific assay to demonstrate that in vivo 15d-PGJ2 levels are actually several orders of magnitude below the levels required to induce many of the biological effects attributed to this molecule.
TITLE: Biosynthesis of 15-deoxy-?12,14-PGJ2 and the ligation of PPAR-gamma
Garret A. FitzGerald
Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Phone: (215) 898-1184
Fax: (215) 573-9135
E-mail: email@example.com
View the PDF of this article at: https:/
15-deoxy-?12,14-PGJ2: endogenous PPAR-gamma ligand or minor eicosanoid degradation product?
William S. Powell
Meakins-Christie Laboratories and Department of Medicine, McGill University, Montreal, Quebec, Canada.
Phone: (514) 398-3864 ext. 094071
Fax: (514) 398-7483
E-mail: email@example.com
View the PDF of this commentary at: https:/
JunD protects the kidney
Fabiola Terzi and colleagues at INSERM, Paris, have defined the role of the protein JunD in preventing renal lesions and renal failure, a devastating consequence of a loss of kidney mass.
The partial loss of kidney mass triggers the compensatory growth of remaining nephrons. In some cases, this compensatory growth becomes excessive, resulting in renal lesions and end-stage renal failure. The transcription factor AP-1 is composed of Jun and Fos proteins and plays a crucial role in the fine-tuning of cell proliferation. Terzi and colleagues used JunD-/- mice to define a key role for this transcription factor in preventing renal lesions following nephron reduction.
The model showed that nephron reduction induced a bimodal proliferative response. JunD was dispensable for the initial proliferative phase but essential for preventing a late phase that leads to kidney lesions. The regulation by JunD was found to involve upregulation of the paracrine mitogen, TGF-alpha. Expression of a transgene encoding a dominant-negative isoform of the epidermal growth factor receptor prevented hyperplasia and development of renal lesions in JunD-/- mice. Dissection of these regulatory networks opens avenues for identifying genes involved in the susceptibility to renal disease.
TITLE: JunD protects against chronic kidney disease by regulating paracrine mitogens
Fabiola Terzi
INSERM U426, Paris, France.
Phone: 33-1-44-85-62-70
Fax: 33-1-42-28-15-64 E-mail: firstname.lastname@example.com
View the PDF of this article at: https:/
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Warning: This document and the Journal of Clinical Investigation papers to which it refers, may contain information that is price sensitive with respect to publicly quoted companies. Anyone dealing in securities using information contained within this document or within advance copies of the JCI, may be guilty of insider trading under the US Securities Exchange Act of 1934.