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What exactly is SEO?
SEO, also known as Search Engine Optimisation in full definition, is referring to one of the many marketing software tools that are being utilised in modern recent days, as technology advances.
The importance of SEO
SEO is one of the easiest and best marketing methods to search for leads, hunt down potential business deals, eventually in the hope of closing the potential deals and working with them on long-term partnerships. Not only that, but SEO Melbourne also helps companies to understand their marketing loopholes via the reports generated from SEO and adjust the content to target to the customer segmentation that the companies always want to attract.
SEO Strategy Types
There are many different steps to having an effective and efficient SEO for a marketer to understand and portray their marketing campaigns, though some of these strategies may not be as principled as they seem to be. For instance:
• Website Optimization
There are several factors to consider for marketers to check if the website portraying to their customers are appealing and can optimise the customers' experience while searching for their required information online. They can check on factors like:
o The mobile-friendliness of the website
o Technical bugs that have yet to be debugged or resolved on the site
o User-friendly website domain links that can be easily understandable by people
o The information on a website being augmented to its best to be searchable on search engines
• Constant Content Creation Updates
Readers and customers visit websites that are interesting and have constant information updates, especially for search engines. Whenever information is input in the search engine to be searched on the entire Internet, the search engines tend to boost up the site pages which are on a constant update of content creation.
• Website Glocalization
Marketers also like to localise their websites according to many different factors, like geographical, language, etc. This is to provide a personalised and closer-bonded customer experience for their readers, visitors or customers to browse and read through their sites. Not only that, but marketers also realise that with their websites being localised on a globalised platform, the attracted customer bases are drawn and filtered according to their nearest locations, hence the word glocalization is used by marketers often.
• Links Structure
This is a long-term SEO strategy which needs marketers to constantly implement backend links to ensure the strong brand positioning of the website on the search engines. These backend links are used to learn about new websites and increase your site's branding position as well.
• Content Branding
This content branding is to promote SEO by marketers through the information searched online. To ensure the content branding stays efficient and effective for their marketing campaigns, marketers must make sure that their content branding is affiliated to their SEO strategy. They are required to decide their customer segmentation, the best and useful methodology to reach to their customer segmentation and even measure their marketing results via quantifiable units to check on their marketing statuses online.
The popularity of SEO Usage
SEO is getting relatively popular to be implemented by marketers, especially in Melbourne. This popularity surge is also due to the effective response for marketers to understand their marketing campaigns strengths and loopholes, and the simplicity on how the marketers can implement these SEO strategies to improve and showcase their products and services to the right customer segmentation that they will like to target on.
SEO in Melbourne
Melbourne marketers have researched and are convinced that regardless of which SEO strategy types they use to cultivate their campaigns on, there is no one-size-fits-all SEO strategy. It will be ideal that the marketers, especially in Melbourne, implement all SEO strategies and combine to customise into a unique marketing strategy to fit their campaigns.
Rising SEO Marketers in Melbourne
Since the past decade, there is an increasing number of marketers shifting its traditional marketing methodologies to the modern and state-of-the-art SEO and SEM practices to help their products and services to make known to more people in their customer bases. SEO marketers, with the help of SEO, will be able to find more prospective business deals, customer leads and maybe even increasing their online profits to a heightened level that may be doubled or tripled from their existing profit amounts.
Rising Customer Bases in Melbourne via SEO
Not only that, but the customers also have the information searching made easier for them via SEO. With their information input in the search engines, the results reflected from the search engines can be filtered according to their locations, to the most viewed websites related to the information required. Customers will be able to reach out to the marketers easier, with just a click away. This also applies to those customer segmentations that are in Melbourne as well.
SEO marketing in Melbourne can be deemed to have more linkages with the Google search engine platform. Though there are other search engines like Bing, Yahoo or Baidu, Google search engine platform is the most commonly used by customers to have their information input and to be searched online; and SEO marketers in Melbourne have a clear understanding on this fact after much research. Hence, they usually will focus their SEO strategies to be optimised for Google search engine platform, with the combination of the other above mentioned strategies like links building to reach out to their customer bases on a long-term basis, to provide a stable amount of leads in their customer pools, so as to ensure their profits will maintain or increase tremendously with their prospective customers. As time passes with the marketers' SEO marketing foundation, their websites will get better each day and their website ranking on Google search engine platform will also increase over time. Not only that, but marketers in Melbourne are also able to churn out various reporting charts to show how well their SEO marketing methods are working for their campaigns on their websites in promoting their services and products online.


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La Festa di Roma is the official new year event organized by Comune di Roma, so…
…happy new year to all of you!
We started this 2019 in a great way, in a beautiful location with the right people.
We joined FLxER Team, Flyer Communication, and Palaexpo to realize an audio visual interactive installation.
La Festa di Roma was a great chance to work on the spin off of ONN Frame and we decided to give birth to "ONN People", an interactive audiovisual installation based on the contents of our live performance.
ONN People interactive installation was placed in Basamento Aventino which is under Giardino degli Aranci, one of the most beautiful places in the hearth of Rome.
Basamento Aventino usually is closed during the year and opens only on special occasions.
More info about ONN People here.
Have a shiny interactive 2019!

subset: commoncrawl


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Our Mission
Our mission is to connect youth to the arts by way of professional artists of all disciplines in order to encourage peace and healing through the arts. In this expressive learning environment, we integrate concepts in conflict resolution into our art projects and develop real Peacemakers in the process.
Program Overview
We integrate elements of music, poetry, painting, theater, dance, sculpting, and cooking into our activities to stimulate the children and help them express themselves, as well as retain our general message of peace and cooperation. Our activities focus on creativity, stress relief, community building, health, and conflict resolution. We encourage the children to avoid violent conflict by defusing the situation or seeking mediation. This is accomplished by using creative conflict resolution as a consistent theme in our projects. Our programs foster an open creative atmosphere complimented by professional instruction and guidance. Meaningful art projects are central to our mission.
M-F EST: 9am - 5pm


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We don't get time to discuss the full #CPV2018 survey report but manage to discuss some of the key features such as the significance in the change from CPV to CCVAB, definition, underlying causes, sibling violence and strategies for supporting. You can read a summary of the survey here or but the full report here.
As the discussion progresses we get onto World Mental Health Day, National Adoption Week and banter.
Again, thanks for listening, sharing and downloading. If you're inclined a wee review on iTunes is always welcome.


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Orchestra of the Southern Finger Lakes
- 52 W Market St
- Corning, NY 14830
- (607) 936-2873
- Visit Site
The Orchestra of the Southern Finger Lakes (OSFL) is the area's only professional orchestra. Under the baton of conductor Toshiyuki Shimada, its musicians come from across central New York to perform four full orchestral concerts a year at the Corning Museum of Glass or the Clemens Center in Elmira. The OSFL organizes a three concert chamber music series at Corning's Rockwell Museum. The OSFL also oversees a Junior String Ensemble, a Youth Orchestra & the Chorus of the Southern Finger Lakes.
Cookies are used for measurement, ads, and optimization. By continuing to use our site you agree to our privacy policy.


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For gentle FACE exfoliation: Silk Sea Sponges responsibly harvested from the coast of the Philippines. Use the wet sponge on soapy skin to gently buff away dead skin cells and dirt. The minerals contained in sea sponges nourish and benefit the skin. These include, but are not limited to: calcium, magnesium, sodium, iron, zinc, and potassium. Simply rinse and hydrate. All Natural Sea Sponges are a renewable resource. 1 sponge per bag [2.5-3"]
Payment & Security
Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.


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Regular price
PREORDERS HAVE NOW CLOSEDAVAILABLE BY SPECIAL ORDER ONLYPlease Contact Us For Availability Before Ordering
Please choose your road name and cab numbers from the selection provided below and we'll do the rest!
Please choose your road name and cab numbers from the selection provided below and we'll do the rest!
When new EPA regulations took effect in 1980, the radiator fans were replaced by quieter Q-fans creating the Phase 3 version of the F40PH. Phase 3 F40s share other spotting features with the Phase 2b F40. Many Phase 3 units were built for commuter agencies as well, but without dynamic brakes.
Amtrak's F40PH units were eventually fitted with nose ditch lights. Around the same time the cab side steps and door were modified. Several F40PH units were sold to second-hand owners for use in regional and tourist services.
Rapido will offer both versions of the Phase 2b – original and ditch light-equipped with modified cab details – as well as a non-dynamic brake Phase 3 commuter unit.
Our new HO scale F40PH models continue the unprecedented level of detail offered on our Phase 1 F40PH model.
Following on the success of our HO scale Amtrak Phase 1 models, Rapido Trains Inc. is pleased to announce the Phase 2 Amtrak F40PH in HO scale. Our model has been scaled from original Amtrak and EMD blueprints and has been designed with the help of F40PH fans and current members of the Amtrak team who are themselves model railroaders. Customers can thus rest assured that the locomotive is dimensionally accurate from nose to tail.
Amtrak's second F40PH order incorporated several changes to the original Phase 1 design. Phase 2a and 2b units (230-279, 280-328) received larger 1800-gallon fuel tanks mounted toward the front of the frame. The air reservoirs were shifted toward the rear and to the engineer's side, while the battery boxes were located on the fireman's side. Newer and wider Nathan K5LA horns were specified, requiring a wider horn notch on the cab roof. Units 280-328 (termed Phase 2b) had four vertical ribs at the rear of each side.
Model Features:


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The code of ethics is an institutional reference of personal and professional conduct that should guide the Directives, Collaborators, Contractors and suppliers of an organization, regardless of the position or function they occupy, and functions as a pattern that regulates the relationships between different groups of interest as partners, beneficiaries, communities, society and state so that as a group in their social interactions the Foundation advances towards the success of its mission.
2.1 Ethic
Ethics is the argumentative discipline that seeks to rationally base what we must do to achieve the perfection of each human being, of each organization and of society as a whole.
Ethics does not deal with what one "can" or "could" do from a technical, legal, economic, social, cultural, etc. point of view, but has as a goal to base what we must do to make the person respected in its dignity and the organization achieves the purposes proper to its identity, contributing to the good of itself and the whole of society.
Ethics is concerned with formulating the values, principles and norms that guarantee that both the human being and the organizations in which he or she works achieve the maximum possible welfare and minimize any damage that may be caused to the person, to the organizations or the whole of society.
2.2 Ethical values
Are those behaviors that improve the individual as a person, the company as an organization of people, and society as a community of people.
2.3. Care
It is the courage that drives us to do things well, or to treat others well to keep them in optimum condition.
2.4. Values
Statements that describe the expected behaviors of each one in the development of the activities, both inside and outside the Organization.
2.5. Ethics of care
"Ethical care involves the interaction and moral contact between two people, in which there is an application, in which there is a union between people, as part of the human relationship. From the above we can deduce that the ethics of care is the discipline that deals with responsible actions and moral relationships between people, motivated by an application, and whose ultimate goal is to achieve the care of their peers, their own or the environment.
The ethic of care has to do with real situations, as real as the needs of others, the desire to avoid harm, the circumstance of being responsible for another ... "
Alvarado, A. (2.004). La ética del cuidado, Universidad de La Sabana, Colombia.
3.1. Why have a Code of Ethics?
- Because the mission and vision of the Foundation generates in all its members a commitment to the empowerment and education of the cannabis entrepreneurs of Colombia according to a behavior of participation and leadership.
- Because trust is built by demonstrating a behavior and integrity with our collaborators, and their families, contractors, beneficiaries, state, society and community.
- Because it defines what the Foundation expects from the development of its mission and its team, regardless of their place of work or their training.
- Because it represents a fundamental commitment of the Foundation in ensuring that in all behaviors of employees and other stakeholders always prevail values and ethical principles.
3.2. Who is invited to comply with this code?
All employees, members of the Board of Directors, contractors and suppliers, regardless of payroll, position or geographical location, are invited to understand, apply and ensure that the behaviors established here frame our interaction and performance.
3.3. So we commit ourselves to:
- Encourage compliance with the Code through daily action, our behavior should be a model of what it means to act with responsibility, integrity and respect.
- Ensure that all the work team knows, understands and applies the Code.
- Guide the collaborators and contractors so that in case they have knowledge of a fact that deserves a complaint or ethical dilemma, inform the competent instance.
- To our contractors and suppliers, know, understand and act in accordance with established principles and values.
4.1. Principios
- La Verdad, que está por encima en todas las acciones y relaciones de la Fundación y su entorno.
- El Cumplimiento, que se evidencia frente a los compromisos, normas y procedimientos; y guía nuestras acciones de mejoramiento.
- La Rendición de Cuentas, que permite demostrar la transparencia, calidad de la gestión y uso responsable de los recursos, prevaleciendo el bien común por encima de los intereses particulares.
- El Trabajo en Equipo, que influye en los colaboradores de forma positiva porque facilita prácticas de compañerismo, aprendizaje mediante el actuar cotidiano y garantiza excelentes niveles de comunicación.
- El Trabajo con Profesionalismo, Nos da la capacidad y preparación que caracteriza al equipo humano para el desarrollo de las tareas y proyectos con altos estándares de calidad e impacto.
- La Exigencia y Compromiso, nos permite mantener y aumentar la viabilidad económica de la Fundación, mediante el control de los resultados y sus consecuencias.
- La Consideración y el Cuidado, que sin exclusiones ni discriminaciones ofrecemos a las personas, comunidades y sus entornos donde la Fundación realiza actividades.
4.2. Valores
The actions of the collaborators and contractors of the Network Foundation of Cannabis Entrepreneurs of Colombia, are framed within the following values:
- Believers of inclusion, since diversity allows us to generate better solutions and a global impact.
- Social equality, since discrimination with respect to race, socioeconomic status and gender only brings delays in the quality of human life for all.
Peacebuilders, since sustainable peace is the right of all.
- Fighters of poverty, since poverty is the root of social injustice.
- Global teamwork, since cooperation facilitates the sustainable development of the emerging global business ecosystem.
- Gender equality, since a diverse group of leaders makes better assertive decisions
- Protectors of the planet, since we recognize the implications of unsustainable agriculture for the planet and its latent effect on climate change.
- Opponents of biopiracy, since we oppose the illegal, irregular and / or inequitable access, use and / or use of biological resources and their derivatives, as well as the traditional knowledge of the indigenous peoples associated with them.
- Comprehensive thinkers, since we base our management and leadership practices on integral theories and D3D.
Every person, community and its surroundings, deserve from us the highest consideration and care, without exclusions or discriminations.
Behavior is the reflection of who we are. All the people who, in one way or another, have links or represent the Network of Cannabis Entrepreneurs of Colombia must take into account the following behaviors that reflect our values and principles:
- Each of the actions of the members of the Foundation will be guided by the practices of care.
- I am aware that I know and therefore fulfill and reason for the fulfillment of the duties and prohibitions contained in the legal and regulatory framework that govern me and that govern the contractual links with the Foundation and with the Financing entities; in addition to complying with the internal controls that the Foundation has established.
- I am aware that, as a manager, collaborator or contractor of the Foundation, I represent it at all times, so I always strive to maintain and project an adequate image that involves a careful language and behavior, avoiding any work or personal behavior that deteriorate the good name and reputation of the organization. My actions respond to the dignity and responsibility of my position.
- I actively collaborate in the work groups in which I participate and my actions are testimony for others.
- I comply and I answer for the actions and omissions made in the exercise of my position.
- I am recursive in the search for solutions and in the creation of opportunities for improvement.
- I learn from my mistakes and work on their causes to avoid repeating them, promoting them as a lesson learned.
- I share my knowledge and experiences with my colleagues, in order to promote joint growth and leave a legacy to new generations.
- It facilitated adaptation and helped overcome obstacles to new team members.
- I welcome and promote a safe environment, responsibly expressing my disagreements. I am concerned about the improvement of interpersonal communication and the work environment and I avoid accepting or generating inaccurate and unfortunate comments that affect the people with whom I relate or who violate the good name of the Foundation.
- I refrain from giving concepts or making judgments of a personal nature, which go against the image of the Foundation or of any of its officials.
- I know and I adopt the intellectual property policies that the Foundation manages inside.
- I promote the security of information and therefore I prevent the leakage of strategic or confidential information. I do not disclose by any means whether electronic, printed or audiovisual, improper, illegal, pornographic or racist information.
- I am concerned about having the required competencies so that all my processes respond with the best possible quality to the needs of the beneficiaries and other stakeholders.
- I present in a truthful, timely and verifiable manner the information and products of my management, as well as that of my area and that of the Foundation when it is required within the attributions assigned to me.
- I conserve, protect and use the resources assigned to me in an austere, efficient and transparent manner, including compliance with the times and hours of the working day and their exclusive use in work or management related to my duties.
- I promote and work for self-care and the care of others, avoiding situations that affect or endanger health, life and the environment.
- I comply with and promote compliance with the Fundamental Safety and Health at Work Rules.
- I try that my actions preserve and improve the environment and the social environment that surrounds me.
This Code does not frame all possible situations to which a person may be confronted; therefore, circumstances and common sense in each case must be taken into account.
All queries, complaints or ethical dilemmas that arise must be treated under strict parameters of: Confidentiality, Objectivity, Respect and without allowing any type of reprisals.


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We are very much aware of the importance of continuing training for our technicians.
This way we guarantee a quick and efficient service in all our areas of expertise.
Servycat's permanent objective is to guarantee the health and safety of our workers and we implement all the necessary preventive measures and tools required to comply with Workplace Health and Safety Legislation.


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The best CMS in 2016
Many things change over the years. Others don't.
Many things change over the years. Others don't.
This week, we've relaunched our website with a refreshed design courtesy of our friends at the Palasthotel. When I launched freistil IT back in 2010, I hired Markus (who later joined me as my business partner) to build me a Drupal website. Later, we switched to WordPress. This latest incarnation now is based on Middleman, a static website generator. All the pages are generated locally, uploaded to the web server and delivered as-is. Why did we make this radical change?
There's a single reason: content creation workflow.
We're DevOps experts and we're used to efficient tools and clear worflows. We use our favourite text editors to write code and documentation. We use Git to put everything under version control, to propose changes as pull requests, and to review code before it is released. We use testing frameworks like RSpec and a Continuous Integration process to make sure our work meets our quality standards.
When we encountered Middleman, we asked ourselves: What if we applied the same tools and workflows to our work on web content?
This is the result of this thought process. Our website with all its content is now in a Git repository and every change is reviewed in a pull request before it goes live. This applies to all kinds of changes:
Merging a pull request automatically triggers a CI run which runs RSpec tests on
the website source code. These tests make sure we adhere to basic rules and
quality standards like
Do all important pages have meta descriptions and
keywords? and
Do all Markdown documents adhere to our style guide? Only if
integration tests are successful, the static site content is deployed to
the web for public consumption.
Being able to use the same basic workflow we've been using for years in DevOps
now also for content generation makes us much more efficient. No more pasting
HTML code into web forms; just a simple
git push. In a tiny team with heavy
time constraints such as ours, improved efficiency means a lot. Enough to ditch
the powerful dynamic content management systems for something lean and nimble.
We've put a lot of work into this relaunch and we're so happy with the design support we got from Palasthotel (separation of concerns FTW!). The new website will be the platform for many product campaigns, some of which are already in the works. And now that we've reduced friction to a minimum, we are determined to crank up the helpful-articles machine. So make sure to watch this space!
We're at a critical fork in the road in terms of data protection for EU
businesses and citizens. Yesterday, the European Parliament debated, and today
will vote on, the proposed
Privacy Shield agreement between the EU and US.
Privacy Shield is heavily contested and by many experts regarded as more a fig
leaf than a steel piece of armor. In her article in today's Irish Times, Karlin
Lillington calls Privacy Shield a
clumsy replacement for the Safe Harbour
One of the most criticised aspects of Privacy Shield is how it addresses the protection of data from secret law enforcement scrutiny in the US, a key issue highlighted in the Schrems case before the European Court of Justice. In this matter, Privacy Shield relies only on US government letters of assurance, which are far distinct from actual changes to law.
Equally weak are the foundations provided for the independence of the proposed US-based ombudsman, who would report to the same US State Department that oversees the US surveillance agencies. Lillington cites European ombudsman Emily O'Reilly expressing her concern in a letter to the EU commissioner responsible for Privacy Shield:
It would be useful at this stage if you might outline, or reflect on, how these criteria might be reconciled with the fact that the office foreseen in the 'EU-US Privacy Shield' would be part of a government department that supervises government agencies… European citizens… have legitimate expectations of the credentials as to the impartiality and independence of such an office.
A similar concern was raised by the Working Party of EU data protection
authorities, which said in April that Privacy Shield still needed considerable
work. In
Opinion 01/2016 on the EU–U.S. Privacy Shield draft adequacy decision, the Working Party (
WP29) welcomes the establishment of
an Ombudsperson as a new redress mechanism but then adds:
The WP29 is concerned that this new institution is not sufficiently independent and is not vested with adequate powers to effectively exercise its duty and does not guarantee a satisfactory remedy in case of disagreement.
This has significant consequences on the fundamental rights of EU citizens with regard to data protection:
Finally, although the WP29 notes the additional recourses made available to individuals to exercise their rights, it is concerned that the new redress mechanism in practice may prove to be too complex, difficult to use for EU individuals and therefore ineffective.
The Working Party also finds that key data protection principles as outlined in European law are not adequately addressed in Privacy Shield. This especially applies to the collection of personal data:
The WP29 however notes that the representations of the U.S. Office of the Director of National Intelligence (ODNI) do not exclude massive and indiscriminate collection of personal data originating from the EU. The WP29 recalls its long-standing position that massive and indiscriminate surveillance of individuals can never be considered as proportionate and strictly necessary in a democratic society, as is required under the protection offered by the applicable fundamental rights.
Businesses who process protected customer data, for example in their web applications, require a solid legal foundation on which they can operate securely. In its current state, Privacy Shield does not seem to provide an adequate implementation.
As a company with the internet at the core of our business model, we at freistil IT believe that raising the bar for data protection will benefit both businesses and individual citizens in the long run. With adequate data protection measures in place, they will be able to navigate, use and expand the digital space with peace of mind. As Lillinton concludes:
In an age replete with evidence of easy digital surveillance, poor digital security protections for citizen data and enthusiastic bulk data gathering by both businesses and governments, [regulatory barriers] are also essential protections to a vulnerable citizenry.
Nothing comes for free, though. Putting these protections in place requires a significant effort on both the organisational and the technology level.
In this regard, running your websites on our managed hosting platform freistilbox can become the cornerstone of your data protection strategy. As a PaaS company, we can leverage economies of scale to minimise the cost of these efforts for our customers. That's why we can offer you world-class hosting for Drupal and WordPress at affordable rates. And this includes full data sovereignty: Our business, our staff and our IT infrastructure are based 100% in the EU, with no ties to US-based entities.
So if you, as a web agency or a website owner, have concerns about providing proper data protection at economically viable cost, you should talk to us.
The ImageMagick tool suite is a popular solution for the processing and modification of image files in web applications. Many Drupal and WordPress websites use it behind the scenes. On freistilbox, ImageMagick is installed on both the web application and shell login boxes.
On 3 May 2016, a whole list of vulnerabilities in ImageMagick, nicknamed
[ImageTragick](https://imagetragick.com), was published. Due to an
insufficient sanitisation of command arguments, these vulnerabilities allow
attackers to execute arbitrary commands and connect to remote websites.
Immediately after the publication of ImageTragick, the freistilbox operations team implemented a workaround that blocks these exploits. Thanks to our automated system management, this workaround has been installed consistently on all servers that use ImageMagick.
The security of our customers' websites is our first concern, and we're doing our best to make sure that you can work efficiently and sleep peacefully.
New customers often ask us how they can deal with email using their website's domain. The short answer is: There are a lot of options outside of freistilbox that solve this issue much better than we can.
With freistilbox, we focus on delivering world-class web hosting. Operating an email service is a completely different area of expertise. While we have experience in the setup of email infrastructure, running an email service at the same level of quality as our web hosting platform would require changes that we're not going to make for the time being.
Just as freistilbox offers a much better web hosting solution than our customers
could get by
just setting up a server, we decided that our customers deserve a
better email solution than us
just setting up a server. That's why we
recommend using third-party services that make email their business focus.
All freistilbox application and shell login boxes are equipped with a Mail Transfer Agent (MTA) that allows your web application to send email. This alone doesn't guarantee that your emails will be accepted by their recipients, though. If our servers aren't formally authorised to deliver email in your (domain) name, there's a high risk they'll quickly get blacklisted as potential spam sources.
Additional measures like including our servers in your domain's SPF record can lower that risk. But often still more effort is necessary to ensure your messages will reach their recipients.
That's why we recommend using a specialised email delivery service in the first place, especially if you're going to send more email than the occasional registration notice. Here are a few well-known options for transactional and marketing email delivery:
There are Drupal modules and WordPress plugins available that make the integration of these services into your web application easy. If you need any help in setting up email delivery in Drupal or WordPress, just get in touch with our support team.
Despite all the attempts to kill it, email still is much too critical for business communication to just provide it as an add-on service without giving it the focus it deserves. That's why we don't support receiving email on freistilbox at all. Instead, we recommend using an email provider such as the following:
Our customers choose freistilbox because we're good at what we do. It just makes sense to take the same approach with regard to email service providers.


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Pharmacometrics in Drug Development
Pharmacometrics in Drug Development
Pharmacometrics uses models based on pharmacology, physiology and disease for quantitative analysis of interactions between drugs and patients. This involves Pharmacokinetics (PK), Pharmacodynamics (PD) and disease progression with a focus on populations and variability.
Pharmacometrics is emerging as a science that quantifies drug, disease and trial information to support efficient drug development and regulatory decisions. Drug models describe the relationship between exposure (PK), response (PD) for both desired and undesired effects, and individual patient characteristics.
Disease models describe the relationship between biomarkers and clinical outcomes, time course of disease and placebo effects. The trial models describe the inclusion/exclusion criteria, patient discontinuation and adherence. Typical focus of Pharmacometrics has been on drug models, also referred to by terms such as: concentration-effect, dose-response, PKPD relationships.
Dose Response Relationship
The PK/PD and/or dose-response relationship describes the change in effect (response) on individuals caused by differing levels of exposure (or doses) after a certain exposure time. Studying dose response, and developing dose response models, is central to determining "safe" and "hazardous" levels and dosages for drugs. This information can help identify an appropriate starting dose, the best way to adjust dosage to the needs of a particular patient, and a dose beyond which increases would be unlikely to provide added benefit or would produce unacceptable side effects. Dose-concentration, concentration- and/or dose-response information are used to prepare dosage and administration instructions in product labeling. In general, useful dose-response information is best obtained from trials specifically designed to compare several doses. Conducting dose-response studies at an early stage of clinical development may reduce the number of failed Phase 3 trials, speeding the drug development process and conserving development resources. It is important to choose as wide a range of doses as is practical and safe for patients to evaluate clinically. A widely used, successful, and acceptable design, but not the only study design for obtaining population average dose-response data is the randomized parallel, dose-response study with three or more dosage levels, one of which may be zero (placebo). From such a trial, if dose levels are well chosen, the relationship of drug dosage, or drug concentration, to clinical beneficial or undesirable effects can be defined. Note that a single dose level of drug versus placebo allows a test of the null hypothesis of no difference between drug and placebo, but cannot define accurately the dose-response relationship.
FDA perspective of Pharmacometrics
The Pharmacometric division at the FDA reviews a variety of Pharmacometric analyses types including population PK, exposure-response (or PK/PD), biomarker-clinical outcome modeling, and simulations to determine optimal dosing based on benefit-risk assessment and therefore it has been emphasized for the need for early interaction between the FDA and sponsors to plan the development more efficiently. FDA review was performed in 2006. They surveyed fiscal years 1995 and 1996 and found 23% of NDA submissions contained population pharmacokinetics and/or pharmacodynamic reports(1). The use of the population approach (population pharmacokinetics/ pharmacodynamics) provided useful information for the drug label in 83% of the 47 submissions on safety, efficacy and dosage optimization. However, in 17% of the 47 applications, the use of the approach did not yield any positive impact because the population approach was not integrated into the original plan of the drug development program.
Another review was performed by V. A. Bhattaram where he assessed the role of Pharmacometrics in making drug approval and labeling decisions. Cardio-renal, Oncology, and Neuropharmacology drug products divisions were surveyed from 2000 to 2004. About 20% of the studies included a pharmacometric component from which about 50% had their Pharmacometric analyses being pivotal in regulatory decision making.
The overall conclusion was that Population pharmacokinetics should, therefore, be integrated into drug development.
When should we perform Pharmacometric Analysis?
Pharmacometric analyses are designed, conducted and presented in the context of drug development, therapeutic and regulatory decisions. The single-most important strength of such analyses is its ability to integrate knowledge across the entire development program and compounds, and biology. In drug development, the population approach can help increase knowledge of the quantitative relationships between drug input patterns, patient characteristics, drug disposition, and responses. The population approach may be used to estimate population parameters of a response surface model in phases 1 and 2B of clinical drug development, where information is gathered on how the drug will be used in subsequent stages of drug development and after release (through the use of estimated population dose response relationship). The population approach may increase the efficiency and specificity of drug development by suggesting more informative designs and analyses of experiments. The population approach can also be applied to phases 2A and 3 of drug development to gain information on drug safety (efficacy) and to gather additional information on drug pharmacokinetics (and pharmacodynamics) in special populations, such as the elderly. It is also useful in post-marketing surveillance (phase 4) studies.
Pharmacoemtrics at Bioforum
Bioforum provides Pharmacometrics services to projects of preclinical, early clinical Phase and late clinical phase product development. These include Pharmacokinetics (PK), Pharmacodynamics (PD) and disease progression with a focus on populations and variability.
The Pharmacometric group works in parallel with multi-disciplinary Bioforum clinical development teams, specifically biostatistics, clinical data management and medical writing aimed at producing the highest-quality and informative documents.


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Webcasts & Speaking Engagements
Buckley Sandler Webcast: Automotive Add-On Products - The Regulatory Landscape and the Road Ahead
Within the last 18 months, automotive industry participants have increasingly come under scrutiny from government regulators, including the CFPB, the Department of Justice, and state Attorneys General. On a parallel track, there has been a multi-year focus on the marketing, sale, and servicing of add-on products that can be sold in connection with a financial transaction across a number of industries.
Of late, regulatory focus is moving toward the intersection between auto and add-on products. From extended warranties to GAP insurance, regulators are now focusing on the marketing, sale, and servicing of products that may be sold in connection with transactions involving automobiles. The first enforcement actions are emerging and these actions hold the potential to have implications for lenders, dealers, and product manufactures alike.
Please join us for a panel discussion among Jonice Gray Tucker, John Redding, and Kris Knabe, who regularly advise clients on auto finance matters.
Panelists will discuss:
- CFPB, FTC, and AG Jurisdiction and Powers
- Recent Enforcement Actions Involving Add-On Products
- Implications for Automotive Industry Participants
- Tips for Managing Risk in View of Increasing Scrutiny
Who Should Attend: This webinar will be of particular interest to in-house legal, compliance, and risk management personnel in the automotive industry.
When: Tuesday, March 3, 2015 from 2:00 to 3:15 pm ET
Registration required. Please no outside law firms, government agency personnel, consulting firms, or media. After registering and being approved, you will receive a confirmation email containing instructions for joining the webinar.


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Decided to take a half day trip with my 2 boys for bass out of Kennebunkport. The fishing was so good we kept the boat for a full day! After filling the live well with mackerel, we anchored up in some key spots in the ocean and in the river. Steady pick of fish all day from 28" to 38.5". I guess we had about 15 fish landed with probably as many dropped. Here is a picture of my 9 year old fishing buddy Danny with his largest bass yet at 38.5"!!! He managed this fish on his own despite 3 drag peeling runs. He even said half way through the fight "I am going to get this fish on my own". Nice day. Way better than we expected.
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Terms under which this service is provided to you.


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Off Road 32 Inch C3 Series Curved LED Light Bar
Powerful 32 inch Combo Curved LED Light Bar
Power: 135W---(13500lm)
LED Quantity: 135pcs high intensity LED chips(99LED@spot beam,36 LED@flood beam)
Operating Voltage: DC 10-30V (Fit 12V/24V vehicle)
Beam Angle: 10 degree(spot beam) & 150 degree (flood beam) combo
Color Temperature: Pure White 6000K
Working Temperature:-40-85 degree Celsius
Dimension(without bracket): approx 820mm(32")*80mm(3.15")*65mm(2.5")
Dimension(with bracket): approx 880m(34.6")*90mm(3.5")*65mm(2.5")
IP67 water and dust seal,about 50000 hours life time
Material: Black Die-cast Aluminum profile,PC lens,metal side brackets
Certified by CE & RoHs
Subversive spot & flood optic system,high density light spread makes dark night become daytime
Tri-row LED spot beam configuration,nest reflector cup encircled pushes light efficiency to max, little unused light
Broad reflective plate allows multi wide angle refraction,ideal for ambient lighting
Designed to project maximum pure white light to the road,no dark zone or foggy light in close quarters
Oversized grooved heat sink fins extends cooling surface for quick heat elimination
Full die-cast aluminum profile,wear & corrosion resistant enough to withstand any harsh environment,also doubling as heat sink
Off-Road vehicles-ATVs,SUV,truck,Fork lift,trains, boat
Specialized vehicles-Fire engine,police cars,rescue vehicle,communication vehicle, military command vehicle etc.
Engineering vehicles-Excavator,dozer,road roller,bulldozer,crane and mining truck etc.
Package Included:
1x 135W C3 curved LED light bar
2x side brackets


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BPO Companies in India
Posted by Eiffel tower Facts on Jun.23, 2016, under BPO Companies in India
Allsec Technologies, One among the renowned BPO Companies in India and they have highly qualified professionals.
They help Companies by taking the full Responsibility over the Project, adding the Value to the Business with their Personalized Back Office Solutions.
We are fully trained to handle all types of media channels including Email, Voice, Chat and social media.
See also: Call Quality Monitoring | Back Office Support
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Pentecost 14.18 "Hypocrisy" Mark 7:1-13 "Why don't You wash Your hands before You eat, Jesus!? And why don't You say the "Come, Lord Jesus" (like all good Lutherans!) before you eat, Man?" (NIV translation). It's not only kind of rude, but it breaks with centuries oldRead more →
Pentecost 13.18 "Real Food" John 6:51-69 We live in an age of a lot of fake stuff: fake news, fake empires, fake wealth, fake history, fake leaders—spiritual and political. And though the fraud is exposed time and again, we seem to have an appetite, a preference even,Read more →
Pentecost 12.18 "Runaway Food" John 6:35-51 I think I was about 5 or 6 years old. My mother told me the story when I was "grown up". Apparently, I'd had enough. Too many chores around the house. Not enough cartoon time. Too many time outs. General lackRead more →
11 Pentecost 11.18 "On Feasting, Not Dieting" John 6:22-35 A good diet is so important, don't you think? Lots of people tell me so. My head spins when I hear all the different diets friends and family are on these days. There's low carb, high carb, SouthRead more →


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Goblinquest: A Book ReviewLeave a comment
September 7, 2014 by JImbo
Goblinquest Book Review
While it won't be confused for "serious literature", this was more fun to read than Dante's Inferno or Melville's Moby Dick.
A LOT more fun.
Essentially the whole theme of the book is to show what an "epic adventure" is like from the point of view of an average lowly goblin. Alright well not exactly. MOST goblins would be hacked to pieces on page 7 by the adventurers. Obviously "Jig" the Goblin is not an ORDINARY goblin.
He does bring a different perspective to the action however. For example to him a kitchen knife without rust on it is a treasured weapon. His greatest threat isn't some undead necromancer. It's the old fat cook who runs the kitchen. And running away is a perfectly INTELLIGENT way to respond to a dragon!
The book (well series now) is a send-up to many well-worn tropes we simply accept in our adventure takes. For example, why is it a GOOD thing to go out and fight a dragon? Isn't it smarter to stay home and not probably die?
Why is there always an elf, a dwarf and a human in the party?
Why is there always a thief, a cleric, a magician and a fighter in every party?
Why is everyone always after treasure?
And why isn't it considered impolite to barge into an occupied dungeon and start breaking and stealing things? That's sorta racist isn't it? Are we just cheering on racist bullies and thieves?
Not that Jig is himself a paragon of virtue. He's all for stealing and such. He just thinks it's hypocritical to not be HONEST about it. Gobins don't pretend to be noble and "good" while looting the bodies of people they kill.
It's a thought provoking as well as funny book. It helps if you're read or seen some fantasy books and movies.
I look forward to finding the next installment. My only concern is if Jig starts to get too "un-Goblin." The Goblins are portrayed as a sort of "noble savage" who are kept down by "the man." For example the Goblins learn English ("Common") as the language of the world, but no one bothers to learn Goblin. So, having Jig adopt the manners and lifestyle of the adventurers seems a bit too much like the whole idea that "The Bloody Africans would be okay if they'd just act like Englishmen!"
Or maybe I'm reading WAY too much into it as usual.
Anyone else read it?
Am I way off base here?


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Roughly 77% of companies in the United States offer their employees some form of online training today. As organizations grow and scale across geographic bounds, offering online training to new and existing staff, as well as providing virtual meeting portals, generates great efficiency. Here are four ways that e-learning can provide your business a powerful competitive advantage.
Remote Working
A major perk for employees today is the possibility to work from home. Particularly if personal responsibilities make it difficult to maintain regular office hours, the convenience of completing training or other requirements virtually can be a unique benefit that attracts top talent. Adding the flexibility to complete online training with a self-study approach also enables employees to autonomously make the most of their time.
For companies that thrive on brainstorming and collaboration, a virtual classroom or meeting space for employees can be just the ticket for generating new ideas. Everyone knows the challenges of jam-packed schedules and how hard it can be to schedule meetings for multiple parties, particularly face-to-face. The ability to meet online helps to alleviate this calendar conundrum for all parties.
Clarity & Consistency
Even the best instructors and trainers can struggle to keep students engaged. An LMS can distribute content in a methodical, gated way to help guide learners with checks and balances along the way. Instructors or facilitators can monitor completion and adherence as well as control the information that is disseminated to protect brand standards.
While on-site or off-site events can include training sessions or special events, the cost of running these physical gatherings can be significant. By leveraging the power of digital, e-learning proves to be a cost-effective and scalable way to teach and connect. All that's required is an Internet connection and quality content - no smoke machines or strobe lights.
A platform that facilitates virtual meetings, training and collaboration can be just the thing to maximize productivity and company culture. While it may be impossible to arrange in-person meetings or professional development sessions, using an online tool like ScholarLMS offers companies an unparalleled way to communicate and connect.
Be sure to check out the full range of features available with ScholarLMS. Our paid plans have access to the full range of options to help give you the best e-learning experience. Talk to us to find out more!


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Independence Day means many things to many people. For the sweaty, half-soused, sun burnt throngs congregated at the corner of Surf and Stillwell Avenues on Coney Island, it's about a display of unparalleled gluttony and over-indulgence that no other country in the world could dare replicate.
For those not willing to sweat it out in the 90-degree steam bath provided by the island, the expert, borderline Peabody Award-winning coverage by ESPN provided even more joy than the contest itself—as was the revelation that Takeru Kobayashi sat the contest out due to a "labor impasse with Major League Eating" and was later arrested for struggling with police on stage.
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While the astronomical gastronomical deeds of the eaters outside the hot dog ring are too numerous (and quite frankly, too ludicrous) for me to list here, I've broken ESPN's coverage into its two major categories of hyperbole. First, there's the asinine introduction of the eaters, which ranges from the allegedly athletic to the tragically melodramatic to the downright Biblical. Then there are the graphics comparing eaters to real athletes, a serious affront to any fan of sports.
So first, the introductions by announcer George Shea:
Crazy Legs Conti: He was buried alive under 60 cubic feet of popcorn and he ate his way out to survival, and he learned the mysteries of beyond in the process. The David Blaine of the bowel; the Houdini of cuisine-i.Tim "Gravy" Brown: Even as a suckling child, it was apparent that he was a competitive eating savant, one who can see the truth behind the truth, behind the truth. It is said that he can smell the flavor of a touch, taste the color of a sound. His understanding of food goes beyond anything we could ever imagine. Ga-Ga-Ga-Ga-Gravy Brown.
Juliet Lee: Heaven must have rusted through on the bottom because angels have fallen in among us.
Eric "Badlands" Booker: The top gurgitator extraordinaire; the one who eats to the beat of the flash and flare. (Also, the 400-pound Booker is a subway conductor on the 7 train in New York. So if you're on the train and it's a little sluggish, it's probably because of the continent that's steering the train. He's joined in the interesting occupations category by Ben Munson, a dietary nutrionist by trade whose lessons hopefully don't include the merits of eating 29.5 burritos in 10 minutes.)
Sonya "The Black Widow" Thomas: Some say she is the absence of beauty, the shadow under the lotus petal. Others are less charitable. They say she is a living sign of the apocalypse, a force of evil who eats with a cloven tongue, a daughter of Cain locked in battle with the Sons of Abel.
Patrick "Deep Dish" Bertoletti: He is not an athlete. He says he is more of an exotic pet owner, because his intestine is an anaconda that tightens until it twists the life from the small animals he feeds it.
Bob "Notorious B.O.B." Shoudt: His obligations smother him like the heavy wet earth of a premature grave. And the makeshift crosses on the shoulder of the highway remind him of his own mortality and his failure to create a lasting legacy for himself and his family.
Tim "Eater X" Janus: He's a solitary man who keeps his own counsel. Inscrutable behind a painted mask. Perhaps he conceals his face to hide from crimes committed in another nation. Perhaps he hides from crimes he has yet to commit.
Joey Chestnut: What does he mean? Americaaaaaa! America is a dream forged in the minds of its heroes, a fragile reality made possible only by those who understand greatness and the way to achieve it. Before you stands just such a man, ladies and gentleman. His figure is crafted from clay by the fingers of the Almighty himself to stand in a position of honor in the permanent collection of the museum of all time. The eater of the free world.
Now for the indictment of the ESPN graphics department:
Takeru Kobayashi's innovation of dunking the buns and separating dog from bun (groundbreaking, I know!) is equated with Candy Cummings development of the curveball, Eddie Cochem's institution of the forward pass, and George Mikan's introduction of the slam dunk.
Michael Phelps diet of around 12,000 calories a day is compared to the almost 21,000 calories Chestnut devoured in 10 minutes last year with his 68 hot dogs and buns. I'd like to see it compared to the number of refugees in third world countries that could be fed for a day. I'm just assuming the hot dogs scarfed down in the contest could have fed Darfur for a week.
"Passing of the Fork: From one Diner-sty to the Next", which compared Kobayashi's six-year reign followed by Chestnut's now four straight titles to the transition from Pete Sampras to Roger Federer, Cheers to Frasier, and the Ming Dynasty of 1368-1644 to the Manchu Dynasty of 1644-1912.
"Rookie Monsters" like Wilt Chamberlain, Eric Dickerson, Teemu Selanne, and Munson are also compared. One averaged 37.6 points per game, one rushed for 1,800 yards and 18 touchdowns, one scored 76 goals, and one defeated Chestnut in a flautas eating contest. All equivalent honors.
Graphic comparing "Notable women in a men's world", relating Thomas' rise to the number five in the world eater rankings to such accomplishments as Billie Jean King's win in the Battle of the Sexes over Bobby Riggs.


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ELLESSE FROM JDNovember 10, 2017
JD have lots of new Ellesse clothing in at the moment and it's so nice. You can find camo leggings, a bright orange crew neck jumper, red hoodie, bright yellow long sleeved t-shirt and lots of cute pink stuff.
I am wearing the grey joggers with Ellesse tape detailing and the long sleeved crop polo top with Ellesse tape detailing. They look really cute together and could be worn as a two piece as they have the matching tape details. They're also soo comfy.
I paired them with some all black Air Max 97s, I've wanted a pair of all black trainers for ages so these ones are perfect for me as 97s are my favourite at the moment!
Ellesse Collection
Ellesse Long Sleeve Polo Top
Ellese Tape Fleece Pants
Black Air Max 97s


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Monitor All Your IT Assets with Our Network Operation Center Services
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Gift Voucher
Regular price
Or 10 interest free payments from $ 7.00 NZD with What's this?
Cant quite decide on what to give? Have you left it to late for the big day?
A physical gift certificate with envelope can be couriered out to your shipping address.
If you would like to gift a specific piece but are unsure of the names, artwork or baby's birthdate. We are able to make the voucher out for completed piece. If the piece is from our handprint collection, we will also include a ink-less printing kit which can be given along side the voucher. Please email - email@example.com to request a invoice.
The finner points
- Shipping includes standard NZ courier shipping of the finished piece to the recipient
- Gift vouchers are available in set amounts starting from $70
- All gift cards have a 12 month export from purchase date
- Gift vouchers are not redeemable for cash


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Durham School Services will host the hiring event and job fair Saturday, January 14 from 8:30am – 12:30pm at 1384 Farmville Rd., Memphis, TN 38122. Durham is looking for Drivers and Bus Assistants. For more information please contact Roderick Woody at 901.636.7953.
- Recruiters will conduct on-site interviews
- Applicants need to bring current driver's license and social security card.


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Men's luxury watches are becoming one of the most invested accessories on the market. Here at Laings, we pride ourselves on our fantastic collection of men's watches. We have carefully chosen only the finest brands including Omega, Longines, IWC and many more with the highest quality pieces to add to our selection. Watches for men are a rite of passage, a symbol of special occasions and are one of the most popular gifted items for gents. We have a variety of styles that include everything from men's automatic watches to men's dress watches, a timepiece to suit every style and occasion.
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5 Items


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We get lots of questions about what the difference is between our Original Silent Feet (in the green package) and our Anti-Walk Silent Feet (in the red package). The answer is very simple. But let me start by saying that there is no "better" product, they both absorb the same amount of vibration and provide exactly the same amount of protection for your home. In fact, there are only two things that are different between the two products (three, if you count the color of the packaging). Those two things are the style of the two rear pads in each set.
Why are the rear pads different? Because when we first invented Silent Feet washing machine pads, we wanted them to be the easiest pads to install on your washing machine and dryer. So we covered the bottom of the rear pads with felt to allow them to slide. This allows you to pull the machine away from the wall so that you can easily place the rear pads under the washer. Then you simply slide the washer back into place and insert the two sticky front washer pads under the front feet. Poof! You're done and the two anti-walk front feet hold the washer in place preventing minor to moderate walking.
But then one day we had a customer call us up and ask if they could have a set of Silent Feet with 4 of the sticky pads? We said sure! And Anti-Walk Silent Feet washing machine pads were born. To make installing Anti-Walk Silent Feet easier, we recommend wetting the bottom of the two rear pads with a 50/50 water and liquid dish washing detergent mixture. This will allow the pads to slide slightly while you adjust the position of your washing machine. Then place the two front feet, allow about an hour for the water to evaporate off the rear pads and you're all set.
We hope that answered your questions about the differences between our award winning washer pads. For over 5 years now, Silent Feet have been the most effective washer pad on the market. Try them in your laundry room today!