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Small Groups
Can you imagine being part of a church home where almost every single person is in a loving circle of friends with a trained leader that provides nurture and care? Where the communities of believers really do love deeply and forgive deeply and open their faults and problems up to each other and hold each other accountable? Wouldn't that be something?
At River of Life, small groups are great places to connect and to grow. As a matter of fact, you are a little out of step if you're not in one! For the past few years, over 85% of all regular attendees have been connected to a group of some kind.
What does a typical cell group meeting look like? It is modeled after Acts 2 so it will usually include a study, fellowship, food, and prayer. As groups do life together, they often are involved in service projects, outreach events, and celebrating milestones such as the births of babies and baptisms.
If you are new to our church or have never experienced group life, you can attend one or more to help you in the exploration process. The best way to begin is to contact our Lead Pastor, Carter MacFarlane, at 651-483-1970 or by e-mail: email@example.com, and he will help you find a group that is right for you.


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- I'd like to determine a summer's worth of dates, locations and routes before the first event so that participants can plan ahead and spread the word. We're looking at hosting a monthly event May-September. Where would you like to ride?
- We will need volunteers to help at the start-finish location during the ride (clean-up/prep), and also a few folks to help stop traffic at any busy crossings. Most of these routes will be through neighborhoods, but we'll have to cross an arterial somewhere along the way no matter where we go. And someone must bring up the rear, a sweeper. Can you do one of these tasks? Could your spouse do it while you're on the ride?
- I'm handling logistics with the City (liability insurance is required if they are promoting the event as part of Bike Month), and also doing some preliminary searching for potential sponsors as we move through the summer. Would you or your business like to be a sponsor? This could be snacks, beverages, bike decorating materials, helmets, money for event insurance, etc.
22 February 2013
Kidical Mass Tacoma - Coming Soon!
I've been talking to parents around town for at least a year, gauging interest in a monthly family-oriented bike ride. The interest is there. Parents want to find more opportunities to ride with their kids.
Inspired by the folks in Eugene, Oregon, who started Kidical Mass, and then spurred on by groups in Portland and Seattle, TBR will be organizing Tacoma's first Kidical Mass ride to take place Saturday May 4th, 2013, as part of Bike Month. (Go mark your calendar right now!)
What is Kidical Mass? It's a casual bike ride for people of all ages and abilities that gives kids an opportunity to share the road. Kids are traffic, too! The goal is to introduce children to cycling in a fun, safe, and low-key atmosphere. We'll ride in a group and leave no one behind, use quiet side streets, have volunteers stationed at arterial crossings, have snacks at the end (and maybe before), and hopefully have some sort of theme that makes the whole thing more exciting. Rides will likely be out-and-back loops at first, starting and ending somewhere fun: a playground, a donut shop, or even a beach. The rides also give parents a chance to share ideas on what works when it comes to family biking setups (cargobikes, and trailers and trail-a-bikes, oh my!), share tips on teaching kids to ride, and create a support network or riders who are willing to nurture everyone's enjoyment of cycling. Obviously there's a tongue-in-cheek reference to Critical Mass, but really this is all about having a good time.
I'm posting this announcement early because I will need some help.
Posted by Matt in Tacoma at 9:38:00 PM
Labels: family, Kidical Mass, kids, Tacoma
2 comments:
- amocat said...
Some ideas for rides: Jefferson park to Proctor for treats (Sugar Candy Shop, Frozen Yogurt) or a movie (maybe we could coordinate something with the Blue Mouse, Pee Wee's Big Adventure!) or Jefferson Park to Legendary Donuts on 6th Ave. I'm so glad you're doing this, my son and I ride home from school every day, but it's always just his lone bike in the bike rack, it'll be so much fun for him to get a chance to ride with other kids, can't wait.
- February 22, 2013 at 11:17 PM
- Matt in Tacoma said...
Those are great ideas, Amocat. I look forward to meeting you on the ride, but feel free to reach out via email if you want to talk about getting more kids biking to your school. I'm hopeful that this summer ride series will blossom into an increase in bike-to-school traffic in the fall.
- February 24, 2013 at 11:48 AM
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From stimulation to control - using Bone Morphogenetic Proteins for controlled regeneration under compromised condition.
The aim of this focus area will be to understand the complex mechanisms of BMP signalling in vitro and in vivo and derive strategies for controlled delivery of these potent cytokines to compromised patients in clinical settings.
BMP signalling plays a crucial role in bone development, homeostasis and regeneration. Further investigation of BMP signalling is necessary to determine the optimal release conditions for the stimulation of healing. Specifically for aged or compromised individuals, an effective treatment strategy using BMP signalling is still lacking. Furthermore, in vitro and in vivo analyses have demonstrated that biomechanical loading may influence BMP signalling, but an understanding of the molecular mechanisms underlying these processes remains unclear and will be a central aspect of interdisciplinary research within the BSRT. The basic principles of BMP signal transduction will be further analysed (Knaus' lab). RNA-Seq technology (Mundlos' lab) will be integrated into these studies for a molecular understanding of the bone defect healing after BMP stimulation. The bioinformatics and molecular modelling labs (Schütte's lab) will perform integrative analysis of genomics data including RNA-Seq in order to improve understanding of bone defect healing on a genomic scale and to identify promising candidates for targeted research. BMP mutations involved in human diseases will be investigated and new BMP variants will be developed for more effective stimulation of endogenous repair (Seemann's lab). Promising BMP variants will be evaluated in human MSC's from compromised patients (Perka's lab). Further analysis of BMP variants will be performed in vivo using bone defect models in order to understand how BMP stimulation is influenced by physical constraints (Duda's lab). These studies will be complemented by the development of specific drug release systems based on degradable multifunctional polymers (Lendlein's lab) to facilitate specific and sequential BMP release at the site of injury.


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Future Favorites is an awesome blog feature created by Alex over at Electrifying Reviews. I post about a book that is yet-to-be-released that I can't wait to read!
Styxx by Sherrilyn Kenyon
Release Date: September 3, 2013 by St. Martin's Press
Just when you thought doomsday was over...
Centuries ago Acheron saved the human race by imprisoning an ancient evil bent on absolute destruction. Now that evil has been unleashed and it is out for revenge.
As the twin to Acheron, Styxx hasn't always been on his brother's side. They've spent more centuries going at each other's throats than protecting their backs. Now Styxx has a chance to prove his loyalty to his brother, but only if he's willing to trade his life and future for Acheron's.
The Atlantean goddess of Wrath and Misery, Bethany was born to right wrongs. But it was never a task she relished. Until now. She owes Acheron a debt that she vows to repay, no matter what it takes. He will join their fellow gods in hell and nothing is going to stop her.
But things are never what they seem, and Acheron is no longer the last of his line. Styxx and Acheron must put aside their past and learn to trust each other or more will suffer.
Yet it's hard to risk your own life for someone who once tried to take yours, even when it's your own twin, and when loyalties are skewed and no one can be trusted, not even yourself, how do you find a way back from the darkness that wants to consume the entire world? One that wants to start by devouring your very soul?


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Please use this identifier to cite or link to this item:
|Testimony, trauma and performance: Some examples from Southeast Asian theatre
|Waterson, R.
|Issue Date:
|Waterson, R. (2010-10). Testimony, trauma and performance: Some examples from Southeast Asian theatre. Journal of Southeast Asian Studies 41 (3) : 509-528. ScholarBank@NUS Repository. https://doi.org/10.1017/S0022463410000287
|This paper is a reflection on a number of theatre performances held in Singapore, each of which probed problematic or traumatic historical events occurring either in Singapore itself or in other parts of Southeast Asia. These avant-garde performances were inspired by or built around actual testimonies of individuals in ways which, for this author, suggest a striking fluidity in the boundaries between testimony and performance, one that raises difficult questions about performance ethics and the processes by which collective memories are shaped. The plays also made use of visual media: one had been recorded on video while others incorporated photographic and video materials into the actual performance. At the time I witnessed these plays, I had already become interested in the way that, over the course of the twentieth century, documentary films had come to play an increasingly important role in the recording of testimony concerning traumatic events. 1 Testimony on film, I have argued, functions simultaneously as evidential trace, and as performative event. Films of testimony develop their own trajectories as they enter into the realms of public remembering. They preserve and extend the record of personal experiences, thereby adding them to the pool of collective memory about an event. Theatrical performances, too, develop their own trajectories through repetition, as Marvin Carlson's statement (cited above) suggests. But what exactly might be different when testimony is performed as drama before a live audience? What are the purposes of such performances, and what might be their possible effects upon both participants and audiences? Is the trace left by a live theatre performance inevitably more ephemeral than those captured on film, or might it be in some respects even more powerful? These are some of the questions I raise - without necessarily being able to present definitive answers - in what follows. I conclude by arguing that in the Singapore context, because censorship laws place very specific constraints on the making of documentary films with openly political content, in recent years theatre has been able to offer a slightly greater space than film as a medium for critical reflection. How theatre directors and actors have tried to use this space is a subject correspondingly deserving of our close attention. Copyright © The National University of Singapore 2010.
|Source Title:
|Journal of Southeast Asian Studies
|Appears in Collections:
|Staff Publications
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The door to her apartment loomed before her. Screaming for Dennis, she didn't stop running knowing he'd open it and close it behind her. She dropped her purse and peeled off her wet clothes. By the time she reached the bathroom, she was naked.
"Cold. So cold." Her teeth chattered and her entire body shook as she turned on the hot water and stepped into the steaming jet. She turned in circles trying to warm all of her skin as quickly as possible. The face of the earsplitting banshee broke her blank thoughts and sent a new wave of crawling flesh up her arms.
She opened her eyes to stop the image but the face played like a movie on the rippled shower curtain. "No, no, no," she screamed as she yanked the plastic curtain aside and saw nothing but tile and steam on the other side. Backing up under the water again, afraid to close her eyes, she rubbed her pebbled skin urging the blood to warm and course again and stop the endless quaking in the pit of her stomach.
Slowly her body absorbed the heat of the shower. The trembling subsided when the dying woman failed to reappear. Her back to the flow, she arched her spine and allowed the heat to wash out the chill from her tresses. Still too scared to close her eyes for long, she blinked furiously to keep the water from splashing and burning them. Finally, calmed and breathing without effort, Cordy wrapped a thick towel around her body and stepped from the tub.
Her bedroom was dark. A spear of dread kept her from entering.
"Dennis. Lights please." Her bedside lamp glowed, but there were too many shadowed corners to afford her comfort. "More. All the lights, please." Obediently, Dennis turned on every light in the apartment. "Thank you, Dennis."
She rubbed her skin raw with the deep-piled towel and then dabbed her hair with it to catch any drips. Slipping on a heavy sweatshirt and pants, she didn't feel normal until she wrapped her feet in thick, fuzzy socks. Warm and relaxed at last, she sighed and sat on her bed to comb out the tangles. The teeth of her comb scraped on the back of her neck and she hissed from the pain.
"Ow! What the hell?" Scooting off the bed, she went to her mirror, turned and lifted her hair. There from her nape to just below her collar were four jagged scratches. "How…when did that happen?"
She touched them gingerly and found they were dry and swollen, but not scabbing yet. Must have scratched myself in my sleep or maybe during the vision. She shrugged. Something as normal as scratching herself made her feel all was right in her world again. This was typical and real and reminded her that freaky as the day had been, this was her life.
She laughed at her earlier behavior. Running through the streets like a hunted animal. Running from a dream. That's all it had been. A daydream caused by the vision. She was tired and had just dozed off and picked up the vision where it left off. That's all.
And now that she'd analyzed what had happened, she realized her head was pounding. "Thank, God. Vision headache alive and kicking." She took ten minutes to dry her hair and then slid under her comforter. "Dennis, you can turn off the lights now." Fear yanked at her chest as the darkness surrounded her, but when nothing jumped from the shadows she chuckled at her stupidity and shut her eyes.
She was bloody and smelled delicious. His mouth watered, his fangs bared and his tongue swept the air to capture more of the delectable aroma. She wasn't far ahead of him. The rapid drumming of her heart and her labored panting were music carried on the mist to his sensitive ears. Then he was on all fours sprinting through the thick, damp underbrush, his nostrils guiding him like an arrow toward his prey.
The rough bristly fur that covered him shimmered when it met moonlight and looked like folded silk. Pride in his strength and power surged from his chest and energized his muscled limbs to pump harder. She was only yards ahead, her feet stumbling, her arms grasping for a savior made of more than fog or wood. Her terror titillated him making his hunger boil up into a deafening roar that shattered the deathly stillness.
She screamed in response, a mistake that slowed her just enough for him to close the gap. Leaves and dirt kicked up from her running feet slapped his face. He leaped and pushed her down ending the chase. He growled in victory and roughly smacked her shoulder rolling her over. Pouncing on her, he pulled back his lips to bear his razor sharp fangs and raised his talons to slash her throat. As his hand arced through the air toward her, he recognized the crazed frightened hazel orbs just before…
"Cordelia!" Angel shot up in his bed, shock and delight warring in his body. "Holy shit. What was that?" He gulped for air and clarity. His eyes searched the room for anything lurking, not certain he was fully awake.
As his body unwound from its defensive mode, he began to scrutinize the dream. For sure that *thing* wasn't him. At least it wasn't his body. Whatever he had hopped a ride inside of was strong, malevolent and nothing he'd ever seen or felt before. But he knew what it wanted and it made him tremble with familiar yearning.
The red liquid crystal display blinked 5:34 a.m. He reached for the phone needing to assure himself that she was fine. Fingers pressed three numbers and then hung up. It was just a dream. She's sleeping and needs to rest.
Settling back under the sheets, he stared at the ceiling going through the events in his mind again and again. Finally convincing himself it was just a dream, he slipped back into comforting darkness hoping this time Cordy would be chasing him.
The Rains – Day 12
Cordelia lugged her drenched body from the nightmare bed and weaved toward the bathroom. Sweat beaded her forehead; her throat raspy and raw. With great effort, she lifted her face to the mirror and stared at her haggard image. Hair tangled wildly in the air, dark circles that reached mid cheek, washed out skin that hung from her bones and more scratches on her neck.
Her worn out eyes scanned the marks and her fingertips lightly stroked their length until the burning stopped her.
"I've either got to declaw myself or start wearing gloves to bed." She opened the cabinet pulling out antiseptic cream for the scratches and aspirin for her still throbbing brain.
As she applied the cream, she ran through the dream. Another chase one. This time she looked into the black eyes of the beast before… God, what the hell was she afraid of? "Whatever it is, I'd better get over it soon. I need some uninterrupted sleep, goddamn it."
She shook two tablets onto her palm, picked up the glass and turned on the faucet. The cool water fell and coiled around the drain and slithered into the black void of the pipes. Cordy stared at the sluicing liquid for a long time expecting…something. Something was coming. She waited and waited, every muscle tensed ready to react when whatever it was appeared.
A breeze blew through her hair slamming the cabinet door loudly. Cordy gasped dropping the aspirin in the sink. She blinked away the haze and slowly refocused her eyes on her reflection.
Panting like an 80 year old through chapped lips, her heart stopped with a fresh panic. No matter how hard she tried, she couldn't swallow. The saliva drooled from the corners of her mouth and streamed over her chin. Get a grip, Chase. Breathe and swallow. Babies do it all the time. She took three deep breaths, closed her mouth and stretched her neck. It wasn't very natural, but she concentrated and forced her muscles to contract and suck down the spit.
"God, what's up with that? No way am I going to try to swallow pills that could choke a small country." Turning off the water she padded back to the bedroom to sleep off the pain instead.
She shucked off the heavy sweats and socks, pulled on a tank and boxers and shoved the comforter onto the floor. She was burning up and even the normally smooth cotton sheets irritated her overly sensitive skin.
It was already past ten, but she wasn't giving up on going to work just yet. If she could just get some sleep, she would probably feel well enough to trudge in sometime in the afternoon. She had just pinned her hopes on that thought when the vision hit again.
Her back vaulted and her fingers dug deep into the mattress, sheets twisting in her gnarled grasp. As the woman sank deeper into the wet depths, pulled by some unseen evil, Cordy experienced not only the victim's terror but also something she'd never felt in a vision before…her own fear.
Horror-filled green orbs begged Cordy for help. She knew merely reaching for her could save the woman. Her arm muscles ached to lunge forward. Her fingers burned to break the water's surface and entwine with the delicate ones just below. Nothing stopped her from helping except that worm of dread in her mind that slithered, tunneled and twisted around her courage rendering her powerless. Cordy could only stare in shock as the jewel-colored eyes disappeared behind an inky veil.
A second after she vanished, the last air pushed through the woman's dead lips and drifted upward. The bubbles caught in a whirlpool and started to curl, coalesce and transform from gas to solid. Faster it twirled filtering air from the water molecules and increasing its mass.
Cordy became hypnotized by the beauty and impossibility of it. As it grew its speed became blinding until it was a blurred circle just beneath the water's edge. Her mouth dropped open in awe and her arm stretched forward haltingly, curious but afraid at the same time. Somehow she knew that to touch it would be to give it life.
She started to draw back her hand when a wave crested and wet her fingertip. Instantly the once whirling circle broke form and burst through the surface flying into her mouth and sliding down her throat. Ice-cold fire began strangling her. She felt her pink lungs darken as the fluid form replaced the air with water. She beat at her chest to try to expel the invader but only felt it slide down further. Tendrils of cold began to radiate from her center and loop around her spine…
Her eyes shot open to the sounds of her own choking gasps and high-pitched ringing. A sharp, hot pain ran up her arm from her clenched fists and forced her to focus on the effort of uncurling her cramped fingers.
Still breathing raggedly, she slowly massaged one hand with the other until she could use them to help her sit. Hauling her limp legs over the side of the bed, she drooped from the exertion it took. She splayed a palm on her heaving chest and used the other to dampen down the ringing in her throbbing temple.
When the ringing only got louder, she finally connected the sound to the phone next to her and sighed. "Jesus, enough of the goddamn misery already." Her hand shook as she picked it up angrily and asked, "What?"
"Cordelia? Are you okay?" Angel's voice was clearly concerned which for some reason only pissed her off.
"I'm peachy."
"Are you sure? It took you a long time to answer."
"I said I'm fine." She ground out the last word through locked jaws.
The silence from Angel made her more tense and frustrated. She didn't even have the comfort of being able to hear him breathe.
"Well, gee, Angel, this has been fun, but I've got to get back to dying now. Bye."
"Wait, Cordy! I thought you said you were fine."
She so wished he was there so she could shove a cross down his throat. "Angel, how's your head?"
"My head? It's fine."
"Good! Being my champion and all, I want you to give me your head and you can have mine. Could we do that, huh?" She rubbed her temple and her forehead wrinkled with the piercing waves of pain.
"I guess that means you're head isn't okay? Does it still hurt from the vision yesterday?"
"Actually, that would be the good scenario. But in addition to yesterday's pain, I now have twice the doubly hot poker fun due to the yummy vision I just had."
"I'm…uh…sorry. About the hot pokers. Can you tell me about it?"
"Well, they're long iron rods that you stick in a fire until…"
"I meant the vision, Cordelia. Tell me about the vision."
"Sure, because why would you need to hear about my pain?" In an instant she decided she wouldn't tell him anything about the weird, personal part of the vision. Until she knew what the fuck had happened, she didn't have the energy or good health right now to hammer it out with him.
"Umm, it was the same vision as yesterday. The same drowning woman, except today there was definitely something pulling her down. I still didn't see what it was but it felt…ghost like. Ethereal, non-corporeal, gone with the wind kinda feeling."
"A non-corporeal demon of some kind. Anything else like where or when?"
"Not exactly. It felt really deep and dark so it's either a lake or maybe the ocean." She concentrated on the taste of the water rushing into her mouth and filling her lungs and began to shake violently at the memory.
Angel heard her rapid breaths and heartbeat speed up. He could practically smell her fear through the phone. "Cordy, what's wrong?"
"Oh, uh, the water…it wasn't salty. It's a lake in the hills maybe…the Hollywood Reservoir!"
"Good, that's good. Do you know when?"
"I'm not sure." Frustrated and terrified at the thought of having to go through this again, she let her feelings out. "Damn it! I don't want to have to waste another vision on this."
"Cordelia? What the hell does that mean?" Angel's shock came through loud and clear.
"It means I'm tired of having to go through the hot poker rumba for the same vision over and over again. One vision per victim. That's the rule! What makes this bitch so special?" Her voice hitched and she sniffed back a tear that threatened to ruin her facade.
"Cordelia!" She hated that daddy tone in his voice.
"What? It's the truth. We could be saving three people for the searing pain I'm having because of one. Where's the justice in that? Ya know, don't answer that. Get Wesley on the see-through demon search, and I'll see you later assuming my head doesn't fall off."
Slamming the phone down only made her head pound more. She fell back on the bed and using all the strength she had left pulled her legs up and under the sheets. Clasping the thin fabric tightly around her shoulders, she tried to stave off the chills taking over her body.
"Dennis, the comforter, please."
The tufted cover drifted over her and was tucked in around her in seconds. "Thank you," she murmured as her jaw relaxed under the added warmth and she began to doze at last.


text: ijustlovemath 0 Report post Posted November 13, 2015 I just recently had a need for XY chart functionality in my application. The example NI has on its website was a little too simple, as I needed support for multiple curves. I've attached the VI and some examples, would love to hear any critiques you have. XYChart.zip Quote Share this post Link to post Share on other sites


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Shonky tablet supplier taken to court
ACCC acts on alleged consumer law breaches in Aboriginal communities
ACCC acts on alleged consumer law breaches in Aboriginal communities
Tablet sales decreased by 20 per cent in 2014 according to technology analyst firm Telsyte, and without needing to replace or upgrade a tablet, consumers are turning to wearables with a similar price point as entry-level tablets.
The 2-in-1 laptop tablet hybrid has become a mainstream category, which is good news for the PC category overall, says Asus regional director Portia Chang.
Acer Australia has officially announced the local availability of its unique Aspire R13 convertible Windows tablet/PC, which was recently honoured with a 2015 CES Innovation Award
Australian manufacturer and importer Viano is looking forward to another round of meetings with dealers from around the world when it sets up its stall at the Hong Kong Electronics Fair next month.


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Cinema is often a distorting mirror of society, accentuating its controversies or fooling us by making the phenomenal look ordinary. Yorgos Lanthimos' Dogtooth (2009), is a film of rare, disturbing beauty – so uncomfortably bizarre, actually, that injects you for days after with a relentless feeling of discontent. The film – among others – also marked the so-called 'Greek weird wave', a cinematic label known mostly for its uncanny, off-kilter aesthetics and extreme stylisation of language which became, for movie culture in Greece, an omen for a traumatising period of austerity and precariousness.
Indeed, Dogtooth combines the unvarnished cruelty of Michael Haneke's films with the stylised, social critique of Pasolini's Teorema. It places us in a middle-class household, only to make it look, some scenes later, like a morbid playground of patriarchy. A family with three children, who have been raised within the confines of their home, is living what appears to be an ordinary life. However, no sooner does a crack appear in their polished mundanity than we see the house turned into a microcosmic dystopia: an unforgiving and dispassionate father, a mother both compliant with and complicit in his deeds, and three children – a boy and two girls – who seem existentially unprepared for the troubles of their adolescence.
The children struggle to express themselves, and to settle in the world their parents have constructed for them. In their language everything is distorted: the words, their way of being in the world, of being themselves, with themselves and with the others. These teens have nothing in common with the usual, effervescent youth depicted in the movies: their bodies are clumsy, deprived of their sexuality – or suspended in a sexuality that looks abnormally innocent. Their movements occupy space but seem untuned, misplaced, contrasting even more with the orchestrated environment of their home. Caught between the hilarious and the authentically vulnerable, all three of them convey the opposite of what society would like them to be: normal, and captive in their own bodies. This is most evident in the scene of a manic ballet performed by the two girls to celebrate their parents' anniversary.


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Ozy and Millie: #5 dream
on October 2, 2007 at 12:01 am
Chapter: Comics
Any one else notice that her subconscious kinda looks like ozy in drag
No, regard the tail one can see in the previous strip. I think that she looks more like Millie, dressed up all girly (or her mom as a kid).
You can tell it isn't Ozy by the color of her feet, ears, and the end of her tail. You can only see the ears in this strip but the other signs are visible elsewhere. You would probably also be able to tell by the hands if she wasn't wearing gloves.
i can relate to this
Millie's subconscious dropped her rubber duck hat.
It is just really thin. The Speech Bubble hides it.
Millie's tail is going at #5.
This should be good going forward.


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Start downloading Sea Legends: Phantasmal Light for PC
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$ 19.50 $ 78.00
Check this out ladies! Adorable and unique jumpsuit is striking and such a sophisticated look that can be effortlessly layered for a casual or more upscale style. This is sure to be a go-to staple this season with features like shoulder straps that tie at the back, side slash pockets, and wide legs. Runs true to size and has a relaxed fit.
FREE SHIPPING on orders over $99


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Koch Brothers Believe National Parks Should Be Privatized. While many were celebrating with their families and enjoying festivities this weekend, an op-ed was published in the New York Times that made the case that the nation need not make any new parks. His reason: we cannot maintain the parks we have now. . . . It appears that, in order to address this growing problem, the Koch brothers are interested in privatizing the park systems. The author and co-author of the Times op-ed piece both work for the Property and Environment Research Center (PERC). PERC is an organization interested in "property rights and environmental organization" and funded by none other than the Kochs. Ring of Fire
IL: Chicago Skyway up for sale: Report. Looking to buy a toll road? The long-term lease of the Chicago Skyway has gone up for sale, according to Reuters. The news agency reports that Spanish toll road investor Ferrovial and Australian investor Macquarie are offering their stakes in the toll road for sale to the highest bidder. Ferrovial is the parent company of Cintra. Cintra and Macquarie leased the 8-mile toll road in 2005, paying the city of Chicago $1.83 billion for the right to collect tolls and maintain the roadway through 2104. The Chicago Skyway was profitable in 2014 with revenue exceeding expenses by about $8 million. Land Line Magazine
FL: Fewer of tomorrow's freeways will be free. Fewer of tomorrow's freeways will be free. In exchange, drivers willing and able to pay to avoid the traffic congestion that bedevils everyone else. Toll lanes are an increasingly common solution in metropolitan regions with limited public space or money to widen highways. One increasingly popular idea is to convert carpool lanes to let solo drivers pay for a faster ride. In the future, non-carpool lanes might also be tolled. Florida Times-Union
LA: Legislative auditor: Medicaid privatization savings hard to nail down. Gov. Bobby Jindal's signature Medicaid privatization program may be saving the state money, but it's hard to tell for sure, the legislative auditor said Monday. . . The auditor recommended that the state health agency work with the Legislature to determine whether an independent actuary should be hired to determine if Bayou Health is saving the state money when compared with traditional Medicaid. Purpera's office found flaws in some of the cost-savings reports the state health agency provided the Legislature. . . .Legislators have questioned cost savings in the past. The legislative auditor also has been critical of the information the health agency has provided, including an initial report largely based on data provided by the insurance companies involved in Bayou Health. The Advocate
NJ: Christie and his enablers jeopardize Liberty State Park – Editorial. When we last left the clash over Liberty State Park and its right to exist without some hideous commercial eyesore vandalizing its 600 pristine acres, it was trending unfavorably for the five million annual visitors who enjoy this hallowed ground in its present form. . . . Sweeney and Speaker Vincent Prieto have surrendered, essentially, with another bill that does not remove the Park from Christie's crosshairs. No doubt, it makes significant improvements to the present law (environmental impact mandates, a public bidding process, and one measly day of public hearings), but it still gives authority to the MRC to "implement any plans" for development under the DEP. And that, indeed, has outraged park stewards and environmentalists who have made Liberty State Park an urban monolith without the help of some shopping mall architect… But this plan creates a legitimate fear that development could face few restraints. And now that the legislative fight seems lost, the public deserves to weigh in on projects, even if they're not as large-scale as an amphitheater. Because the way this all started, the inherent distrust – in the process, in the governor, and in the lawmakers who enabled him – is wholly justified. The Star-Ledger


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Meena Creations
Handcrafted sterling silver fine jewelry with natural semi precious gemstones .
The chic and one of a kind designs are for daily wear and should last forever.This is accomplished through clean ,simple design and superb quality.
The jewelry is crafted with love that underlines your personality and sets your best side in scene.
The high quality jewelry comes with a fair and friendly price.
We are proud all our jewelry is made in the USA.
Creation of the Week
This champagne citrine with pyrite brings in an aura of beauty and mystery .
We strive to creating and build a strong community relationships by actively participating in various fundraising and charity events in the North East.
January Birthstone: Garnet February Birthstone: Amethyst March Birthstone: Aquamarine April Birthstone: Diamond May Birthstone: Emerald June Birthstone: Pearl or Alexandrite July Birthstone: Ruby August Birthstone: Peridot September Birthstone: Sapphire October...


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Participants at the July DBE networking luncheon learned more about the 2018 tax changes. Held on July 20, 2018, at the Blue Moose Bar & Grille in Lenexa, guest speaker Angela Motsinger of Motsinger CPA Tax & Accounting LLC previewed the new federal tax changes for 2018 and how the changes might affect DBE businesses. She discussed how to understand and fill out tax forms, maximize deductions, and avoid common errors. She also offered tips and resources to help make tax time go smoothly.
Helpful Tax Planning Tips
- To maximize your tax-saving strategies, be sure to meet with your accountant early to allow time for tax planning.
- If you're not sure how to adjust withholding, check out the IRS's online withholding calculator.
- Ask employees to fill out a new W4 every year so that you are always up-to-date.
- Make sure that you notify your accountant and/or the IRS of any name or address changes as soon as possible to avoid missed notices.
If you couldn't make it to the July DBE networking luncheon, you can watch Motsinger's presentation on our YouTube channel.
Motsinger also announced two upcoming DBE events.
Upcoming Events
- DBE supportive services is hosting a free website building workshop on August 23 from 9:00 a.m. – 4:00 p.m. in Topeka. Spaces are limited so RSVP soon to hold your spot.
- Booths are still available for this year's Construction Career Expo. The event will be held September 25, 2018, at the Kansas Expo Center in Topeka. DBEs are encouraged to participate, and KDOT funds will be available to pay the booth fee. Please contact us for more information.
Planned for the third Friday of each month, the DBE networking luncheons are held at various locations across Kansas. Each event features a topic and guest speaker as well as ample time to network with fellow participants. In August, the website workshop will be held in lieu of a luncheon. Check back for the September luncheon details and guest speaker.


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Sunday 8th June
94 for 3
Harris Aslam 47, Angus Hinton 34*
93 for 6
Chayank Gosain 2 for 11
It was a wet outfield due to the heavy sustained downpour the night before so playing on the Astro was the best option to get a positive game in. This meant that fielding wouldn't be easy with many players sporting their brightly coloured trainers with their whites as Carlton fielded first. Gav and Rory opened up bowling tidily upfront combining well to build pressure until the opener, Savage, was stumped courtesy of quick glove work by Keshav. Rory bowled through and finished with figures of 1-7 off his 4 while Gav changed ends to allow Harris to turn his arm over. The two also bowled well getting wickets to fall at regular intervals with good shots being hit from the odd loose ball. Harris got his man, Sharkey, LBW in the 6th over when we was looking good on 14 after having hit a six up the hill off Gav's bowling previously. From then on wickets fell quickly with bowlers bowling very straight lines forcing the batsmen to hit, this was coupled with some good out-fielding too, the highlight of which was a direct hit run out from Ruari off his own bowling. Cheeky operated well bowling his four overs at the death conceding just 11 runs and picking up 2 good wickets. SMRH finished well with a quick 14 from Kapoor with good shots all around the wicket. The highlight of the batting innings was a well made 25 from Scott Blain that eventually came to an end in the 19th over when he was cleaned up by Cheeky. The visitors ended on 93/6 with all bowlers picking up wickets and keeping it tight.
After a quick turnaround Carlton's openers, Harris and Angus, walked out looking to knock off the below par 93 that had been set. Harris began hitting from ball one with ease as the ball was coming on well off the astro. They made a flying start and a solid base as Harris raced along hitting many boundaries including sixes while Angus rotated the strike from the other end picking up singles. The first wicket, of the set Harris on 47, fell after 10 overs. With the score already on 66 it meant others could go in and knock off the last few. Ruari was the first to try this but unfortunately was bowled having only scored 1 run, this brought the skipper to the crease who too failed to reach double figures as he was stumped by a standing back keeper on 8. While these wickets fell at the other end Angus kept a cool head and delivered some killer blows towards the end to put the game to bed including a huge six, giving the man on the moon a job to do, as it sailed over the far boundary still rising as it hit the tree 3 quarters of the way up. This saw the game won with Angus on an unbeaten 34 having anchored the innings.
Overall it was positive that a game was played given the heavy rain of the day and night before so all credit goes to the ground staff for that. It was a strong and positive start to the Under 18s title defence but still with improvements to be made. Onwards and upwards to the next round against Kelso!
Friday 4th July
126 for 3
Harris Aslam 47, Angus Hinton 46, Ruari Macpherson 22
98 all out
Harris Aslam 3 for 20, Chayank Gosain 2 for 5, Gavin Rittoo 2 for 23
Sunday 10th August, 9.45
69 for 4
Angus Hinton 31, Harris Aslam 22
67 for 7
Gavin Rittoo 3 for 12
The logistics of trying to fix up a match between two sides so far apart meant that both teams were keen to get this game played on a damp and overcast Sunday morning. With a horrendous forecast for later, both coaches agreed to a 15 over a side match with a start at 9.30.
The early start seemed to catch the Arbroath batsmen napping, with 4 wickets falling in the first three overs - three to Gavin and one to Rory. Some big hitting from Arbroath number 3 Goodfellow had the visitors back in the game and it took a good catch on the boundary by Rory off Cheeky to see the back of the big batsmen for a fine 32. A good spell from Harris kept the lid on things and a final maiden by Angus saw Arbroath finish on 67 for 7 – an excellent recovery after such a difficult start.
The established opening pairing of Harris and Angus (below) got the reply off to a sound start with both batsmen mixing watchful defence with some attractive strokes. For the third successive round the pair put on a 50 partnership and thoughts on the boundary turned to the prospect of a 10 wicket win. However, Angus perished trying to hit Waller off the top – a classy 31 from him. Next ball, Harris looked to have got a solid defensive stroke in only to see the ball spin back and roll on to his stumps.
The following over saw Ruari bowled by Robb, before Waller earned a third wicket beating the advance of Craig. However, Matt looked solid and a couple of well struck boundaries took Carlton over the line and on to Finals Day in Linlithgow on the 31st August.
Sunday 31st August
106 for 7
Chayank Gosain 2 for 18
131 for 6
Harris Aslam 35, Ruari Macpherson 24, Angus Hinton 21


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"Various types of partnership with Korean game publishers are already in the making behind closed doors," said China's Tencent about the Chinese government's ban on the import of Korean games. "We are not very concerned about it."
"We are contacting various Korean companies for business ties under the table," said an official of Tencent Korea at the G-Star 2017 held at BEXCO, Busan on November 16. "In addition to Korean game imports, we are making various business ties such as the export of Tencent games to Korea."
"About 100 employees including the vice-chairman from Tencent Headquarters already visited the venue of the G-Star," he said. "We are also having meetings with senior officials from Korean game companies such as Nexon, Netmarble and Bluehole. He said he did not worry much about the ban on the import of Korean games.
"Tencent Korea has about 30 employees. Korea is a very important market for Tencent Headquarters, too," he said. "We cannot disclose business ties with Korean game companies as they are in the making in secret. Various types of alliance with Korean game companies will soon be made public."


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'A World Without:' Antibiotics
We continue Worldview's limited series, "A World Without", with a discussion on the medicine we all need to live. The U.S. Food and Drug Administration stated that they want to actively combat medical drug shortages. FDA Commissioner, Scott Gottlieb said in a FDA press release that, "drug shortages have steadily declined since a peak in 2011 owing to the work of the FDA, industry and other groups." Despite those efforts there has been a continuous shortage of medical products including antibiotics. This phenomenon has trickled overseas as well. Dr. Donald Graham, infectious disease specialist at the Springfield Clinic is the co-author of a study called, "Antimicrobial Agent Shortages: The New Norm for Infectious Diseases Physicians." The study explores the persistent shortage of antimicrobial agents reported by physicians.


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My name is Jake, I am an ASE Master Certified Automotive Technician with more than a decade in the auto repair organization. Fuel pump failure need to be diagnosed and confirmed by a specialist automotive technician before a pump is replaced, given that other car difficulties can mimic a fuel pump failure. Now vocational instruction applications are a lot more popular and apprenticeships are much less frequent. Discover to diagnose equipment employing many scan tools, order components, fill out work orders and shop info for future testing.
The aluminum shell supplies huge amounts of protection against something that you can throw it. As a mobile mechanic that is continually crawling under automobiles, the concentrate lens genuinely aids me pin point where I am looking enabling me to do a a lot more thorough job. You are going to use the latest technology and diagnostic equipment to operate on true vehicles for real buyers in NMC's 13-bay auto shop. The number of jobs for automotive service technicians and mechanics is projected to grow more rapidly than typical for all occupations more than the next decade. The backlit LCD screen isn't something specific, but it has a low power draw and gets the job done. Peneha, J, human resources co-ordinator, Rutherford and Bond Toyota, Careers New Zealand interview, August 2016.
And with the outsourcing of jobs selecting up steam – initial manufacturing jobs, now computer programming, consumer call-center perform, and accounting solutions all going overseas – it should be comforting to know that automotive service and repair is relatively immune to such moves. Students can also take part in a secondary college automotive education programme, called StartUp, to understand far more about the automotive business. Just like any other incentive primarily based job that is not directly supervised, there is always going to be a handful of bad apples.
Substantial information of laptop controls, the capability to diagnose electrical and hydraulic difficulties, and other specialized skills are required to operate on these complicated components, which employ some of the most sophisticated technology employed in cars. There is perform in parts, parts distribution and wholesaling collision repair, painting, and harm estimating vehicle upkeep, repair, and performance upgrades and motorsports. These who hope to one day operate as a vehicle mechanic are anticipated to have excellent GCSE final results in Mathematics, Science, Design Technology and English. Repairing vehicles often means messy function circumstances because of the grease linked with repair operate. A job with a low tension level, excellent function-life balance and strong prospects to improve, get promoted and earn a larger salary would make many personnel pleased.
Automotive service technicians are employed by automotive repair shops, specialty repair shops, service facilities, auto and truck dealerships, and by big organizations that own fleets of autos. Note: Students who are enrolled in the Motive Energy Technician program could be chosen for admission to this selection. It is the beneficial insight and advice that can be gained only by speaking with a person who has gone via the actions necessary to become and held a position as an Automotive Technician.


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The defining feature of the Briar Hill-Belgravia, also know as Fairbank, neighbourhood is its topography. Demographics in this neighbourhood include a large number of families of Italian, Portuguese, and the West Indian heritage living in modestly priced homes with convenient access to transit and highways.
This neighbourhood is bounded by Rogers Road -Dufferin Street - Eglinton Avenue West on the South, Marlee Avenue and Allen Road on the East, Briar Hill Avenue on the North, and the CPR Railway Line on the West.
1. Schools and Education: F H Miller Junior Public School, Fairbank Memorial Community School, Fairbank Middle School, Briar Hill Junior Public School, Joyce Public School, Regina Mundi Elementary, Dante Alighieri Academy Secondary, St. Charles Elementary, Sts. Cosmas & Damian Elementary, St. John Bosco Elementary, Lycée Français de Toronto Nursery (Coed).
2. Food and Restaurants: La Paloma Gelateria & Cafe, Randy's Take-Out (Caribbean), Emma's Country Kitchen (Breakfast & Brunch), Agio (Italian), Raps Authentic Jamaican, Tre Mari Bakery, Pho Ga Banh Cuon (Vietnamese), King's Tacos(Mexican).
3. Shopping, Leisure and Recreation: Eglinton Avenue West is a multi-cultural shopping strip that has been coined "the Avenue to the world", local shops on Dufferin Street, the Castlefield Design and Decor district along Castlefield Road at Caledonia, and the Fairbank Memorial Community Centre at 2213 Dufferin Street.
Eglinton Avenue West Station on the YUS Subway Line - 32 on Eglinton Avenue W - 29 and 329 on Dufferin Street - 161 Rogers Road -


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Where are you from?
Greece – Igoumenitsa
Before being a photographer, tell us what you wanted to be?
When I was young I wanted to become a football player… And I did..I still do though but more as a hobby than anything else.
Tell me about the moment you decided to become a photographer?
I remember that at the age of 12 I held my grandfather's camera and I took a blurry picture of my sister… That was the moment I realised how much I loved this even if I couldn't see clearly what I shot nor I understood what I did…
What was the best advise you received when you started your photographer carrier?
The best advice for me was that, above all I have to do my job with love. Not to care if it will bring me money but only if it fulfils me as a person.. And I do this since day one.
Can you define photography?
Well.. I am not sure I can. The only thing I can say is that photography is a kind of passion and a love that provides you with a variety of feelings. Every time you look a photo is as if you at the eyes of a person you love very much.
For you, what makes a good photographer?
For me a person to become a good photographer needs to have love, loyalty, passion, sentiment, perspective, respect and values.
For you, what makes a good photograph?
A good photo for me always is the one that captures an emotion. When a picture gets to you and leaves you with a good sentiment and a message then you reached your goal.
What is your biggest challenge today?
The fact that I love photography as an idea, a principle and as a story. Plus getting the reassurance from my customers. Their smiles when they see my shots and their persistence to keep me in their lives. I love having good relations with all my clients and exchange our news every so often.
Tell us about the day you felt most proud about your work?
Nice things you hear everyday… My proudest moment was when I picked up the phone and one of my customers kept thanikng me for capturing her dad smiling in a picture which was a rare thing for him to do. She also told me that she was very please that had chosen me to be her wedding photographer. Honestly the joy I felt was indescribable.
Tell us about the relationship you have with other photographers? How important you feel that is.
Maintaining a good relation with other photographers is something very important to me as a person. I have kept close with all the people that I have worked with not only because they taught me things but also because they helped me and chose me as a partner. The competition though is a healthy thing and exists. This way you become better in all aspects of your personal and professional life but most of all better for all the ones you love. To be fair though when I can I also help younger and new photographers with their work. As long as they love what they do.
Can you tell us an advise - photography or business tip - that somehow made your career evolve at any point?
My tip is to love what you do as hard as you can… Appreciate whoever chooses you and when you travel for work enjoy every last second of it. You need to become one with them and get moved when they do. Then all your pictures will not need any form of a retouch because they will be perfect. You will have met the pick of inspiration and good photography.
All in all, I would like to thank the community for your incredible dedication and help that you give to all professionals. I am so glad I can call myself a rocker from now on…!
See More THE ROCKER'S STORIES
Lauren White
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Ricardo Meira
Be Ready To Make Things Different! I´m a Wedding photographer wich started my activity in the world of photography in the year of 2002 in Barcelos, where…
Fernando Garcia
BE Ready to make thinks different! Born and raised in México. At the age of 18 i studied graphic design, then i left it because i was involved…
The Costa Sister
BEFORE BEING A PHOTOGRAPHER, TELL US WHAT YOU WANTED TO BE? We never thought we'd fall into doing wedding videography. We've always been go with the…
Holly Wallace
BEFORE BEING A PHOTOGRAPHER, TELL US WHAT YOU WANTED TO BE? Before I was a full time photographer I worked as a journalist both in print and…
Juan Trujillo (4Events)
BEFORE BEING A PHOTOGRAPHER, TELL US WHAT YOU WANTED TO BE? My first contact with photography was during the university. I studied Advertisement and i always…
Jader Morais
WHERE ARE YOU FROM? Brazil Before being a photographer, tell us what you wanted to be? As a child, I wanted to be an actor. Act in…
Twin Lens Photography
Before being a photographer, tell us what you wanted to be? Isa wanted to work with image and film editing, Gabe wanted to be a fashion /…
Mike Rodriguez
BE READY TO MAKE THINKS DIFFERENT! Mike Rodriguez is a wedding photographer, with a style consisting of colorful, artistic, emotional and energetic imagery. Running a client-friendly, service-oriented…
INSTAGRAM @yourockphotographers


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Mothod and composition for treatment of ischemic neuronal reperfusion injury
Methods and compositions for treatment of, or protection from, neuropathy resulting from reperfusion injury upon reversal of an ischemic condition, comprising treatment or prophylactic treatment of the patient with an antagonist of the type 3 ryanodine receptor, such that a rise in cytosolic Ca2+ concentration is prevented. Therapeutic compositions containing dantrolene or aminodantrolene are administered to the patient to prevent a rise in cytosolic Ca2+ that would otherwise result in Ca2+-mediated neuronal damage. Treatment of ischemic optic neuropathy by this method is shown, and the methods and compositions presented are also applicable to other ischemic reperfusion neuropathies, such as stroke, reperfusion injury after TPA treatment/carotid endarterectomy, seizures, and excitotoxic retinal damage in glaucoma.
[0001] This invention relates to the treatment of neuropathy resulting from ischemic reperfusion injury in a mammal. Such neuropathies include, but are not limited to, optic ischemic neuropathy, stroke, reperfusion injury after TPA treatment or other lytic treatments/carotid endarterectomy, seizures, and excitotoxic retinal damage in glaucoma.BACKGROUND OF THE INVENTION
[0002] When the blood supply to neural tissues such as brain or retina is interrupted, a complex series of biochemical changes begins which may result in neuronal cell damage. At the cellular level, it is known in the art that damage is mediated by opening of the N-methyl-D-aspartate channels in the membrane. Ischemia begins when the blood supply stops or is significantly slowed, and this phase may be followed by restoration of the blood supply during a reperfusion phase. It is well established that cellular damage may occur during both phases, though by different mechanisms. These processes and the mechanisms for damage are described in "Clinical Challenges, Retinal Artery Occlusion" H. S. Mangat, Survey of Ophthalmology 40, 145-156 (1995), which is incorporated in its entirety by reference herein.
[0003] The complex series of events known in the art to contribute to cell death during ischemia/reperfusion are summarized in FIG. 1 in diagrammatic form. FIG. 1 shows six substances that accumulate during ischemia: excitatory amino acids (1), intracellular calcium (2), arachidonic and other free fatty acids (3), hypoxanthine (4), xanthine oxidase (5), and platelet activating factor (6).
[0004] Ischemia triggers at least three pathways deleterious to the cell. Firstly, a lack of oxygen depletes energy stores (principally ATP), which disrupts homeostatic mechanisms, most importantly the membrane pump mechanism that maintains intracellular calcium at a low level. The resulting rise in intracellular calcium (2), which occurs principally because of the opening of the N-methyl-D-aspartate (NMDA) channels in the membrane, increases release of glutamic acid, activates destructive proteases and lipases (7), and indirectly converts the enzyme xanthine dehydrogenase (8) to the potentially harmful xanthine oxidase (5). Secondly, excitatory amino acids (1) ("excitotoxins"), principally glutamic and aspartic acids, are released, which activate calcium channels, further increasing intracellular calcium through a positive feedback mechanism, and allowing entry into the cell of excess water, sodium and chloride. Thirdly, acidosis enhances destructive lipid peroxidation and the release of damaging free radicals (9).
[0005] Upon restoration of the blood supply the reperfusion phase begins. The increased intracellular calcium level (2), a result of opened NMDA channels during ischemia, may now trigger a more destructive cascade. The initial calcium impulse causes a cascade that results in the release of intracellular calcium stores from the intravesicular calcium deposit. The release of intracellular calcium is mediated via the ryanodine receptor, principally the type 3 ryanodine receptor. The net result is a thirtyfold rise in intracellular calcium and cell death. Attempts have been made to reperfuse as soon as possible after the onset of ischemia, but it is important to note that the reperfusion itself causes the cascade, therefore the neurodestructive phases of ischemia and reperfusion are distinct.
[0006] Neurophysiologists now view reperfusion injury as a cascade process that leads to excitotoxic cell death. The rise in intracellular calcium during reperfusion causes vasoconstriction of neighboring blood vessels. In addition, it causes the release of free oxygen radicals (9), in part from the action of xanthine oxidase (5). The net result is excitotoxic neuronal cell death (10).
[0007] Ryanodine Receptor Antagonists
[0008] Increased cytosolic Ca2+ concentration contributes significantly to neuronal cell damage during ischemic reperfusion. It is desirable to prevent or minimize ischemic neuronal reperfusion injury; that is, to prevent or minimize neuronal cell damage that occurs during the reperfusion phase of an ischemic episode.
[0009] Dantrolene is an antagonist of the type 3 ryanodine receptor and is commonly given as the sodium salt (sodium dantrium), which is hydrated 1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidinedione sodium salt. Dantrolene is prescribed in the treatment of clinical spasticity resulting from upper motor neuron disorders such as spinal chord injury, cerebral palsy, stroke, or multiple sclerosis. Dantrolene is also effective in reversing the hypermetabolic process of malignant hyperthermia, a genetic disorder of skeletal muscle that is triggered by exposure to anesthetics and certain relaxants.
[0010] Other therapeutic uses for dantrolene are known in the art. For example, Dreyer, U.S. Pat. No. 5,597,809, teaches the use of NMDA-receptor antagonists, and also dantrolene, for the treatment of optic neuritis. U.S. Pat. No. 5,506,231 to Lipton teaches the use of dantrolene for the treatment of three conditions specifically associated with AIDS: dementia, myelopathy, and blindness. Dantrolene has been used clinically to treat malignant hypothermia, as it is known to reduce cellular energy requirements, creating a hypothermic environment. Kiyoshi (Patent Abstracts of Japan (1994), publication number 06263636) discloses the use of dantrolene for treatment of cerebral nerve diseases such as geriatric dementia, Parkinsons disease and Huntingtons disease.
[0011] Non-therapeutic uses for dantrolene include cryopreservation of blood vessels. See U.S. Pat. Nos. 5,158,867; 5,149,621; 5,145,769 and 5,122,110.
[0012] Ischemic Optic Neuropathy
[0013] Ischemic optic neuropathy (ION) is a distinct condition from optic neuritis (ON), and ION is distinguished from ON by several diagnostic criteria. Typically, ION patients are 60 years or older, while ON affects younger patients for whom 40 years is the typical age of onset. A key event in the development of ION pathology is ischemia, whereas inflammation is essential to the pathology of ON. In the majority of cases, ION is a painless condition. In contrast, ON is reported to be very painful. Finally, and most significantly to the present invention, the visual acuity lost by a patient having ON is recovered in the majority (71%) of cases. In contrast, for the vast majority of ION patients, loss of visual acuity is permanent and spontaneous recovery is very rare. See American Academy of Ophthalmology (1994) pp. 76-83. It is therefore desirable to prevent or minimize the loss of visual acuity.DESCRIPTION OF THE FIGURES
[0014] FIG. 1 is a schematic representation of metabolic pathways involved in ischemic and reperfusion injury to neurons. The six boxes (1-6) immediately above the broken line represent increased concentrations of metabolites, which are formed during the ischemic period but do not cause their damaging effects until they are metabolized during the period of reperfusion injury. Metabolic events during reperfusion are depicted below the broken line, and may lead to cell death.
[0015] FIG. 2 illustrates left- and right-eye optical fields, examined post-operatively in the patient of Example 1.
[0016] FIG. 3A illustrate the confrontational visual fields, 24 hours postoperatively, of the patient of Example 1.
[0017] FIG. 3B illustrates the right eye confrontational visual field, 24 hours postoperatively, in response to a red top.
[0018] FIG. 4 illustrates progression of the visual field of the left eye of the patient of Example 1.
[0019] FIG. 5 shows visual field test results approximately four months postoperatively for the right eye of the patient of Example 1.
[0020] FIG. 6 shows visual field test results approximately four months postoperatively for the left eye of the patient of Example 1.
[0021] FIG. 7 illustrates progression of the visual fields of both eyes of the patient of Example 2.BRIEF SUMMARY OF THE INVENTION
[0022] It is therefore an object of the present invention to provide a method and compositions for the treatment of patients with an ischemic neuropathy, including, for example, ischemic optic neuropathy, ischemic retinopathy, stroke, reperfusion injury after TPA treatment, reperfusion injury after carotid endoarterectomy, seizures, or excitotoxic retinal damage in glaucoma.
[0023] It is a further object of the invention to provide methods and compositions for inhibiting the rise in intracellular Ca2+ concentration that occurs upon reperfusion following an ischemic event. In one embodiment, antagonists of the type 3 ryanodine receptor, including but not limited to pharmaceutically acceptable salts of dantrolene, aminodantrolene, and mixtures of same, are administered to block cytoplasmic influx of Ca2+, and thereby prevent or minimize neuronal reperfusion injury.
[0024] It is a still further object of the present invention to prevent ischemic reperfusion injury in a mammal by the administration of pharmaceutically acceptable salts of dantrolene, aminodantrolene, and mixtures of same.
[0025] In further embodiments, azumolene, cyclopiazonic acid, 2,5-di(tert butyl)-1,4-benzohydroquinone, or mixtures thereof, are used to prevent ischemic reperfusion injury in a mammal.
[0026] Another object of the present invention is to prevent ischemic retinopathy in a non-human mammal or a human patient by administering a compound that inhibits intracellular calcium-mediated retinal cell damage, including pharmaceutically acceptable salts of dantrolene, aminodantrolene, and mixtures of same.
[0027] Dantrolene, aminodantrolene, or an equivalent antagonist of the ryanodine receptor, preferably an inhibitor of the type 3 ryanodine receptor, is used, alone or in combination, to prevent or treat neuropathy resulting from reperfusion of ischemic neuronal tissue in a mammal. Treatment prevents intracellular release of Ca2+ stores, which prevents or ameliorates neuronal damage that otherwise may occur upon reperfusion.
[0028] These and other objects of the present invention will become obvious to those skilled in the art upon review of the following disclosureDETAILED DESCRIPTION OF THE INVENTION
[0029] It is desirable to treat neuronal reperfusion injury by blocking the calcium-triggered cascade that releases intracellular calcium stores. This is accomplished in the present invention by blocking the cascade at a point that is different from that of the so-called NMDA-blockers, such as memantine, that are currently used or in development to treat the ischemic phase of neuropathy. Ryanodine type 3 receptor antagonists such as dantrolene or aminodantrolene, or their functional equivalents, are instead used to block the release of intracellular calcium stores during reperfusion.
[0030] Drugs that can be used in the present invention include dantrolene, aminodantrolene, and azumolene. Other compounds that also inhibit intracellular calcium release, and which may be used in the present invention, are cyclopiazonic acid (thapsaigargin), and BHQ [2,5-di(tert butyl)-1,4-benzohydroquinone].
[0031] The following two examples illustrate the preferred embodiment of the instant invention, in which dantrolene is used to successfully treat two patients with optic ischemic neuropathy caused by anesthesia.
[0032] Methods
[0033] The compounds of the present invention are drugs that prevent release of intracellular calcium by antagonism of the ryanodine receptor. These drugs are administered and dosed in accordance with good medical practice, taking into account the clinical condition of the individual patient, the site and method of administration, scheduling of administration, patient age, sex, body weight and other factors known to medical practitioners. The pharmaceutically "effective amount" for purposes herein is thus determined by such considerations as are known in the art. The amount must be effective to achieve improvement including, but not limited to, improved survival rate, or more rapid recovery, or improvement or elimination of symptoms and other indicators as are selected as appropriate measures by those skilled in the art.
[0034] In the method of the present invention, the compound of the present invention can be administered in various ways. It should be noted that it can be administered as the compound or as a pharmaceutically acceptable salt and can be administered alone or as an active ingredient in combination with pharmaceutically acceptable carriers, diluents, adjuvants and vehicles. The compounds can be administered orally, subcutaneously, parenterally, intravenously, intraarterialy, intramuscularly, intraperitoneally, intranasally, intrathecally and via infusion techniques. Inplants of the compound are also useful. The patient being treated is a mammal and, in particular, mammals including man. The pharmaceutically acceptable carriers, diluents, adjuvants and vehicles, as well as implant carriers generally refer to inert, non-toxic solid or liquid fillers, diluents or encapsulating material not reacting with the active ingredients of the invention.
[0035] The doses may be single doses or multiple doses over a period of several days. The treatment generally has a length dependent upon the length of the disease process, drug effectiveness and the patient species being treated.
[0036] When administering the compound of the present invention parenterally, it will generally be formulated in a unit dosage injectable form (solution, suspension or emulsion). The pharmaceutical formulations suitable for injection include sterile aqueous solutions or dispersions, and sterile powders for reconstitution into sterile injectable solutions or dispersions. The carrier can be a solvent or dispersing medium containing, for example, water, ethanol, polyol (for example glycerol, propylene, glycol, liquid polyethylene glycol, and the like), suitable mixtures thereof, and vegetable oils.
[0037] Proper fluidity can be maintained, for example, by the use of a coating such as lecithin, by the maintenance of the required particle size in the case of a dispersion, and by the use of surfactants. Non-aqueous vehicles such as cottonseed oil, sesame oil, olive oil, soybean oil, corn oil, sunflower oil, or peanut oil and esters, and isopropyl myristate, may also be used as solvent systems for compound compositions. Additionally, various additives which enhance the stability, sterility, and isotonicity of the compositions, including antimicrobial preservatives, antioxidants, chelating agents, and buffers, can be added. Contamination by microorganisms can be avoided by the use of various antibacterial and antifungal agents, for example parabens, chlorobutanol, phenol, sorbic acid, and the like. In many cases, it will be desirable to include isotonic agents, for example sugars, sodium chloride, and the like. Prolonged absorbtion of the injectable pharmaceutical form can be brought about by the use of agents delaying absorbtion, for example, aluminum monostearate and gelatin. Any vehicle, diluent, or additive selected is compatible with the compounds.
[0038] Sterile injectable solutions can be prepared by incorporating the compounds utilized in practicing the present invention in the required amount of the appropriate solvent with various other ingredients as desired.
[0039] A pharmacological formulation of the present invention can be administered to the patient in an injectable formulation containing any compatible carrier, such as various vehicles, adjuvants, additives, and diluents. Alternatively, the compound utilized in the present invention can be administered parenterally to the patient in the form of slow-release subcutaneous implants or targeted delivery systems, such as monoclonal antibodies, vectored delivery, iontopheric delivery, polymer matrices, liposomes, and microspheres. Examples of delivery systems useful in the present invention include: U.S. Pat. Nos. 5,225,182; 5,169,383; 5,167,616; 4,959,217; 4,925,678; 4,487,603; 4,486,194; 4,447,233; 4,447,224; and 4,439,196, each herein incorporated in its respective entirety. Many alternative implants, delivery systems, and modules are well known to those of skill in the art.
[0040] A pharmacological formulation of the compound utilized in the present invention can be administered orally to the patient. Conventional methods, such as administering the compounds in tablets, suspensions, solutions, emulsions, capsules, powders, syrups, and the like are usable. Known techniques, which deliver the compound orally or intravenously and retain the biological activity, are preferred.
[0041] In one embodiment, the compound of the present invention can be administered initially by intravenous injection to bring blood levels to a suitable level. The patient's blood levels are than maintained by an oral dosage form, although other forms of administration, dependent upon the patient's condition and as indicated above, can be used. The quantity to be administered will vary for the patient being treated, and will vary from about 100 ng/kg of body weight to 100 mg/kg of body weight per day, and preferably will be from 10 &mgr;g/kg to 10 mg/kg per day. However, as shown in Example 1, the 1-2 mg/kg body weight as a loading dose is preferred, followed by 1-2 mg/kg every two hours three times, then every 8 hours until the ischemic condition resolves. For glaucoma, neuroprotective daily doses of approximately 0.1 mg/kg can be used. In general, sub-toxic doses as set forth in Physicians Desk Reference, 42nd edition (1988), are preferred. Methodology to determine dosing as set forth in U.S. Pat. No. 5,597,809 can also be used.EXAMPLE 1
[0042] A female patient undergoes back surgery lasting 8 hours and, upon awakening after 16 hours, complains of not being able to see from her left eye. The surgery had lasted 8 hours, and 1 unit of blood had been lost. During surgery, her systolic blood pressure had dropped to 80 mm Hg. She has a long-standing history of hypertension, and subsequent evaluation reveals that she has sustained a myocardial infarction. She is a contact lens wearer, previously having a corrected visual acuity of {fraction (20/20)} bilaterally.
[0043] Post-operative opthalmic examination reveals an uncorrected visual field of {fraction (20/70)} in the right eye, and no perception of light in the left eye. There is a relative afferent pupillary defect on the left. She has a sizeable loss of her right visual field, which is illustrated in FIG. 2. Dilated fundus examination shows bilateral pale optic discs with venous pulsations on the right. Both pupils are reactive, varying in diameter from 3.0 to 3.5 mm. The confrontational visual fields on initial exam are shown in FIG. 2.
[0044] Her extra-ocular muscle movements, intraocular pressures, and anterior segment exam, are within normal limits. Fundus exam shows a pale optic disc with a cup-to-disc ratio of 0.4 in the left eye. The right optic disc is of normal color. However, the superior opthalmic vein is loose from its fibrous attachments to the optic disc. It is pulsatile, and each time a pulse occurs, it jumps away from the optic disc. This can be clearly seen with a 90 diopter lens and a portable Kowa slit lamp, or with a 20 diopter lens and a Keeler indirect opthalmoscope. The retina appears normal in both eyes. A clinical diagnosis in the left eye of posterior ischemic optic neuropathy resulting in no light perception is made. A clinical diagnosis of posterior ischemic optic neuropathy with resultant field defect and pending loss of vision in the right eye is also made. MRI of the optic nerves confirms these diagnoses. Bilateral swelling of the optic nerves is seen behind the optic discs. The swelling is more marked in the left optic nerve than in the right. MRI confirms that she has a swollen optic left nerve. A diagnosis of bilateral ischemic optic neuropathy is made: the blood supply to the left eye has been occluded, and the same process is occurring in the right eye. Just prior to discovering her loss of sight, her serum calcium is low, and the nurse administers intravenous calcium.
[0045] To prevent compression of the blood supply in the right eye, the patient is given high dosed pulsed steroids. However, excitotoxic damage of the retina from reperfusion injury is almost certain in the absence of the treatment of the present invention. Therefore, to prevent reperfusion injury dantrolene is administered as per the present invention, since it is known that dantrolene prevents excitotoxic damage in an animal seizure model.
[0046] The patient is administered 2 gm solumedrol, and then 1 gm every 6 hours. Dantrolene is administered at 2 mg/kg every 2 hours for three treatments, and then 1 mg/kg every 8 hours. She is re-examined 24 hours later and her corrected visual acuity in the right eye is {fraction (20/30)}, while the left eye has light perception. Her confrontational visual fields are shown in FIG. 3A.
[0047] Her confrontational visual fields at 24 hours, in response to a red top in the right eye, are shown in FIG. 3B, and show a significant scotoma to red top.
[0048] A scotoma to fingers (initial scotoma at 24 hours) reflects impending neuronal death of the visual pathway that detects that field. At this time, the scotoma is in the inferotemporal field only, indicating that the neural pathway of the superior nasal retina to the brain is affected. The red top scotoma matched the scotoma at the initiation of treatment.
[0049] Example 1 illustrates the action of dantrolene acts as a neuroprotective agent against reperfusion injury. The inferior field loss lessens 48 hours after starting treatment and continues until there is none at the fifth day. However, the scotoma to red top remains, indicating that an ischemic insult has occurred to the corresponding neurons. Her uncorrected visual acuity returns to {fraction (20/50)} in the right eye by the fifth day.
[0050] The initial restoration of light perception in the left eye 24 hours after initiation of treatment continues to improve. At 72 hours after treatment she starts to perceive hand movement. Her progressive visual field movements are documented in FIG. 4.
[0051] The fields show that dantrolene prevents reperfusion injury. As reperfusion of the left optic nerve is established, the visual acuity and quality of the field improves from no light perception to hand movement. This illustrates that intervention at a time of no light perception helps to protect those neurons that have not yet been damaged, so that they are functional to produce hand-movement vision.
[0052] Two months after discharge, the woman is re-examined. She states that she sees "beautiful colors in orange light" with her right eye. She continues to have a direct relative afferent pupillary defect in her left eye. Her corrected visual acuity in the left eye is counting fingers at distance and {fraction (20/800)} at near distance. Her optic disc photographs and visual fields to both white and red test objects are shown. She maintains her scotoma to red light as described above. This scotoma is absent in the white object visual field.
[0053] FIGS. 5 and 6 show subsequent visual field test results (Macular Field Test: Central 30-2 Threshold Test) for the left and right eyes, respectively, showing the results of the therapy and the return of the patient's visual fields, and thus illustrating the efficacy of the present invention.EXAMPLE 2
[0054] A 64-year-old white male awakes, after an L2-S1 posterior fusion with laminectomy operation, with no light perception in either eye. His past medical history is significant for an episode of hyperglycemia approximately 45 years previously. He has been a non-smoker for the last 20 years, and prior to that he was a heavy smoker.
[0055] The operation lasts for approximately 10 hours. He is under general anesthesia for the duration of the operation. The estimated blood loss is 2200 mL during the operation, of which 1200 mL is replaced via a cell saver, and an additional 2 units of blood is given along with crystalloids. His blood pressure drops once during the operation to 89 mm Hg. Before the surgery he is able to read with glasses. Opthalmic examination, subsequent to the operation, reveals no light perception in either eye, normal versions and ductions with pupils varying from 2 to 5 mm with no relative afferent pupilary defect in either eye. Anterior segment examination is normal, posterior segment examination reveals bilateral pale optic dics that are more marked on the left than the right. Strong venous pulsations are seen at the optic disc of the left eye. A diagnosis of bilateral ischemic optic neuropathy is made.
[0056] He is placed on intravenous dantrolene, 2 mg/kg body weight q 2 hourly×3 followed q 8 hourly. In addition, he is placed on solumedrol, 250 mg q 6 hourly. When he is reviewed 16 hours postoperatively, the visual acuity with glasses is counting fingers OU in the superior visual fields. His visual acuity fields are recorded on a daily basis. On day 3 his dantrolene treatment is changed from intravenous to oral 500 mg po tid. On day 4 color vision is restored and on day 5 all treatment is stopped.
[0057] The progression of his visual fields for both eyes is illustrated in FIG. 7.
[0058] The serum level of dantrolene is 14×10−6 gm/mL on day 4, and 15×10−6 gm/mL on day 2.
[0059] Example 2 illustrates that dantrolene serves as a neuroprotective agent, preventing visual loss once ischemia has set in, as exemplified by restoration of the superior visual fields and count fingers vision in both eyes.
[0060] Dantrolene treatment also prevents the effects of reperfusion injury as demonstrated by maintenance of the visual field and restoration of the color vision.
[0061] Throughout this application, various publications, including United States patents, have been referred to. The disclosures of these publications and patents in their entireties are hereby incorporated by reference into this application to more fully describe the state of the art to which this invention pertains.
[0062] While the invention has been described in terms of various preferred embodiments, those skilled in the art will recognize that various modifications, substitutions, omissions, and changes may be made without departing from the spirit of the present invention. Accordingly, it is intended that the scope of the present invention be limited solely by the scope of the following claims.
1. A method of treatment of neuronal reperfusion injury in a patient with ischemic neuropathy, said method comprising:
- administering to said patient an effective amount of a therapeutic composition comprising a compound that decreases cytosolic Ca2+ concentration caused by said reperfusion injury, and a pharmaceutically acceptable carrier.
2. The method of
- claim 1, in which said compound is an antagonist of type 3 ryanodine receptor.
3. The method of
- claim 2, wherein said compound is dantroline, aminodantroline, pharmaceutically acceptable salts thereof, or mixtures thereof.
4. The method of
- claim 1, wherein said neuropathy is ischemic optic neuropathy, ischemic retinopathy, stroke, reperfusion injury after TPA treatment, reperfusion injury after carotid endoarterectomy, seizures, excitotoxic retinal damage in glaucoma, or a combination thereof.
5. A method for decreasing reperfusion damage to the retina of a patient, said method comprising:
- administering to said patient an effective amount of a therapeutic composition comprising a pharmaceutically acceptable carrier and a pharmaceutically acceptable salt of a compound, wherein said compound is an antagonist of type 3 ryanodine receptor and wherein said compound reduces the increase in cytosolic Ca2+ concentration incident to said reperfusion injury.
6. The method of
- claim 5, in which said receptor antagonist is a pharmaceutically acceptable salt of dantrolene, aminodantrolene, or a mixture thereof.
7. A method of treatment of ischemic retinopathy reperfusion injury in a mammal, said method comprising: administering to said mammal a protective agent which inhibits intracellular calcium-mediated retinal cell damage, in a pharmaceutically acceptable carrier.
8. The method of
- claim 7, in which said protective agent is a pharmaceutically acceptable salt of dantrolene, aminodantrolene, or a mixture thereof.
9. A method of preventing ischemic neuropathy reperfusion injury in a mammal, said method comprising:
- administering to said mammal a pharmaceutically acceptable salt of dantrolene, aminodantrolene, or a mixture thereof.
10. A method of reducing reperfusion damage in a patient suffering from, or at risk of, ischemia, comprising:
- administering to said patient an effective amount of a therapeutic composition comprising a pharmaceutically acceptable carrier and a pharmaceutically acceptable salt of a compound, wherein said compound inhibits the intracellular release of calcium ions.
11. The method of
- claim 10, in which said compound is dantrolene, aminodantrolene, or a mixture thereof.
12. The method as in
- claim 1 in which said compound is azumolene, cyclopiazonic acid, 2,5-di(tert butyl)-1,4-benzohydroquinone, or mixtures thereof.
13. The method as in
- claim 2, in which said compound is azumolene, cyclopiazonic acid, 2,5-di(tert butyl)-1,4-benzohydroquinone, or mixtures thereof.
14. The method as in
- claim 5, in which said compound is azumolene, cyclopiazonic acid, 2,5-di(tert butyl)-1,4-benzohydroquinone, or mixtures thereof.
15. The method as in
- claim 10, in which said compound is azumolene, cyclopiazonic acid, 2,5-di(tert butyl)-1,4-benzohydroquinone, or mixtures thereof.
16. The method as in
- claim 7, wherein said protective agent is azumolene, cyclopiazonic acid, 2,5-di(tert butyl)-1,4-benzohydroquinone, or mixtures thereof.
Type: Application
Filed: Dec 4, 2000
Publication Date: Dec 20, 2001
Patent Grant number: 6462066
Inventors: Harpal S. Mangat (Bala Cynwyt, PA), Gerry Bullough (Drexel Hill, PA), Gary Brown (Floustown, PA)
Application Number: 09727707
International Classification: A61K031/4166; A61K031/05;


text:
Songwriters worldwide are invited to enter the 2018 Vanda & Young Songwriting Competition to go into the running for a first place cash prize of A$50,000, courtesy of APRA AMCOS, Alberts and BMG.
Melbourne singer-songwriter Gretta Ray earned top honours in last year's competition for her beguiling song Drive. "The Vanda & Young prize made a huge impact on what I have achieved in the last year. It assisted me in being able to travel overseas to America, write and work on new music there with amazing people, and provided me with the time to wholly focus on my music. That in itself is a gift," said Ray.
Two runners-up cash prizes are also on offer with second place receiving A$10,000 thanks to AMPAL (Australasian Music Publishers Association) and third place taking home A$5,000 courtesy of media sponsor, Seventh Street Media. An exciting addition to the prize slate this year is A$5,000 for the best 'Unpublished' work.
Since the prestigious competition began, it has not only boosted the careers of winners Megan Washington (2009), Kimbra (2011), The Preatures (2013), Husky Gawenda (2014) and Gretta Ray (2016), but to date has raised over A$800,000 for Nordoff-Robbins Music Therapy Australia (NRMTA).
The 2018 competition is set to take total funds raised past A$1million, with the full A$50 entry fee per song going directly towards the work of NRMTA, which uses music therapy to help people cope with the struggles of living with a wide range of needs. These include children and adults with physical and intellectual disabilities, autism, trauma, illness, dementia, behaviour disorders and learning difficulties.
This year's judging panel features some of the best ears in the business with over 40 songwriters, producers, media and industry professionals confirmed to take part. They include three-time APRA Songwriter of the Year Daniel Johns, electronic artist and triple j host KLP, ARIA-winner Montaigne, and The Bamboos' Lance Ferguson, co-writer on the Kungs vs Cookin' On 3 Burners global smash, This Girl.
Daniel Johns said, "Vanda & Young took Australian songwriting to the world and blazed a trail for the rest of us to follow. I'm pleased to be involved as a judge for the first time and I am looking forward to hearing some new music."
Named after the iconic songwriters and founding members of The Easybeats, Harry Vanda and the late George Young, the competition launch coincides with a month of celebrating one of Australia's most loved bands with a vinyl reissue, a two part mini-series Friday On My Mind on the ABC, and a tribute EP, Rebeat.
David Albert, Managing Director of Alberts said: "Alberts is thrilled to continue its long-term association with APRA AMCOS and also partner for the first time with BMG for the 2018 Vanda & Young Songwriting Competition. This competition recognises the significance Harry Vanda and the late George Young have to the music community through their legendary songwriting partnership, and provides a great opportunity to support Nordoff-Robbins Music Therapy Australia."
Heath Johns, Managing Director of BMG Australia said: "BMG is very proud to partner with our friends at Alberts and APRA AMCOS for the 2018 Vanda & Young Songwriting Competition. The competition provides a unique platform for songwriters to have their music heard by some of the country's finest songwriters and also contribute to an important cause. The prize money on offer should also make a meaningful difference to the eventual winner's career and we are very happy to get behind that."
Matthew O'Sullivan, General Manager of AMPAL said: "AMPAL is very proud to support the Vanda & Young Songwriting Competition. It is a fantastic competition that provides a great opportunity for songwriters, while at the same time contributing to the life-changing work of Nordoff-Robbins Music Therapy Australia."
Entries close 11.59pm (AEDT) 17 January 2018.
Facebook.com/vandayoungcomp (https://www.facebook.com/vandayoungcomp/)
Twitter.com/VandaYoungComp (https://twitter.com/vandayoungcomp/)
2018 Vanda & Young Songwriting Competition Judging Panel
Andrew Mast – themusic.com.au
Bernard Zuel
Bryget Chrisfield – The Music
Cameron Adams – News Corp
Chit Chat
Christie Eliezer – Pollstar
Dan Hill – SCA
Danielle McGrane – AAP
Jake Challenor – Jaden Social
Kathy McCabe – News Corp
Irene Hulme – SCA
Larry Heath – theaureview.com
Lars Brandle – Billboard
Lindsay McDougall
Lisa Rockman – Newcastle Herald
Mickey Maher – SCA
Nathan Davies – News Corp
Noel Mengel
Poppy Reid – The Industry Observer
Richard Wilkins – Nine Network
Rod Yates – Rolling Stone
Shannon Fong – Foxtel Music
Andrew Stone – Chugg Entertainment
Becc Bates – Arts SA
Cathy Oates – Original Matters
Daniel Johns – Singer, Songwriter
Daniel Nall – Rabble Records
Dave MacGregor – Macsta Management
Greg Carey – Grow Yourself Up
Jenny Morris – APRA Chair, Songwriter
Lance Ferguson – Musician, Songwriter, Producer
Michael Taylor – Universal Music Group
Nicole Millar – Singer, Songwriter
Peter Karpin – Sony Music
Rowan Brand – RedGreenBlueCo
Andrew Mackay – Composer
David Ryan Harris – Songwriter
Greg Haver – Producer
Amanda Brown
Brendan Gallagher
Eric Chapus
Grant Windsor
James Blundell
Les Gock
Nordoff-Robbins Music Therapy Australia use creative music therapy to deliver significant and quantifiable benefits to children and adults with physical and intellectual disabilities, trauma, mental health problems, depression and medical illnesses, as well as learning, emotional and behavioural difficulties.
Using improvised live music to build a relationship between the music therapist and the participant where they interact and communicate in a participatory form of therapy, the power of music acts as the agent for change and healing. Nordoff-Robbins Music Therapy Australia receives no government funding yet assist some of the most disadvantaged in our community so fundraisers like Art of Music play an essential and vital role in assisting to continue the great work. For more information: www.noro.org.au
Founded in 1885, Alberts is an independent Australian company which has been managed by the Albert family for five generations. Its history has intertwined with the evolution of Australia's media and popular culture from its early days of sheet music and music publishing through to commercial radio and television and helping establish and develop Australia's music industry.
Alberts has been a longstanding supporter of Nordoff-Robbins Music Therapy Australia through its mission to transform lives through the provision of music therapy. Alberts collaborated with APRA AMCOS in 2009 to establish the Vanda & Young Songwriting Competition, named after the iconic songwriters Harry Vanda and the late George Young, to support and raise the profile of the non-profit organisation, Nordoff-Robbins Australia, and the work it does to change the lives of many.
facebook.com/albertsaustralia/ (https://www.facebook.com/albertsaustralia/)
BMG is a new kind of media company. Our mission is clear; to help artists and songwriters make the very most of their songs and recordings in the digital age. BMG. The New Music Company.
bmg.com/au (http://www.bmg.com/au/)
APRA AMCOS is a key business partner to Australasian music creators. We represent 95,000 members who are songwriters, composers and music publishers. We license organisations to play, perform, copy or record our members' music, and we distribute the royalties to our members.
As a world-leading organisation invested in the future of music, APRA AMCOS enables music creators and customers to maximise the value music brings to business and life. We achieve this through a simple and effective licensing framework, and providing holistic industry support – from education, to live music, export, creators' rights advocacy and recognition through our high profile awards and events program. apraamcos.com.au (http://www.apraamcos.com.au)
AMPAL The Australasian Music Publishers Association Limited (AMPAL) works on behalf of its members to promote a better understanding of the value of music, both culturally and economically. AMPAL has more than 50 music publisher members in Australia and New Zealand who invest in songwriters across all genres of music. They nurture talent, promote the works of their writers and find avenues for their work to be heard. They are a vital part of an industry that contributes to the cultural and economic future of Australia and New Zealand. AMPAL members represent over 90% of the economic value of the music publishing sector.
SEVENTH STREET MEDIA is Australia's largest music publisher overseeing brands and platforms that are a catalyst for conversation and a vehicle to capture the hearts and minds of music fans.
Its titles include The Industry Observer, Tone Deaf, The Brag, Don't Bore Us and J Play.
seventhstreetmedia.com.au (http://seventhstreetmedia.com.au/)