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EFIE-DCP for Trucks
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Electronic Fuel Injection Enhancer
Digital Control Panel
Increase fuel savings in trucks
More details
Here you can view our last shipped orders.
16. This breaks the laws of thermodynamics. It should not work!
A common fallacy is that it takes more energy to produce the HHO than the energy it releases. This is true in part when we see only the electrolysis process but when the HHO gas is mixed with your usual fuel inside the engine it allows the fuel molecules to burn better and more efficiently thus releasing much more energy than before. This is why it works.
17. Do you have a reseller distribution program?
Yes, if you are interested in becoming our reseller please contact us by e-mail to email@example.com
18. Why do your kits costs less than others?
It's because we manufacture and produce all of our products. Due to the large volume of units produced we can buy materials in large quantities at the very best deal and streamline our production and pass the savings on to you. It would make no sense for us to have the best product out there if it were so expensive that the average consumer could not afford it.
19. Can I use a bigger HHO model in my car?
Yes, you can use the immediate above model for your car. The fuel savings will be not much higher but the life span of the generator will increase a lot. For the small price difference between models maybe it is a good investment.
20. What safety devices are in the kits?
We have included in the kit a bubbler and a non-return check valve to prevent any damages if the engine backfires. The bubbler will also wash any traces of electrolyte vapor out of the gas being sent into the engine.
21. Can I use any kind of water?
It is recommended that you use distilled or de-ionized water but you can use tap water if it does contain too much iron or limestone.
22. How often do I have to check the water level in the tank?
Check it about every time you fill your car with a full fuel tank.
23. Why do your kits costs less than others?
It's because we manufacture and produce all of our products. Due to the large volume of units produced we can buy materials in large quantities at the very best deal and streamline our production and pass the savings on to you. It would make no sense for us to have the best product out there if it were so expensive that the average consumer could not afford it.
24. Will installing an HHO kit void my vehicle warranty?
No. It is an add-on device that can be easily removed. Since you are not modifying the engine or computer your HHO kit does not void your warranty.
25. My car doesn't have much space under the hood. Where can I install the HHO System?
There is always some place a unit can be installed. Our Hydrogen generator is the smallest on the market, the size of a motorcycle battery. The best place is in front of the car under the bumper.
26. How much would it cost me to have a mechanic install this?
Installation to your vehicle can be easily done by any good mechanic, or by yourself. Mechanics normally like the idea and respond well once they see the installation instructions. Installation depends very much on your vehicle and the hourly rate of your mechanic. However we can estimate your installation will take between 1,5 hours up to 3 hours.
27. When do I get my instructions manual?
You get acess to the manuals download page immediately after you make your payment. After the transaction you will get instructions to continue to the download page. If you accidentally skip the page or close the browser, just send us an e-mail to email@example.com.
28. Does HHO injection work on vehicles with Turbo?
Yes. HHO works in turbocharged engines. Just make sure to inject the HHO gas before the turbocharger, not after.
Electronic Fuel Injection Enhancer
Digital Control Panel
Increase fuel savings in trucks
More details
In the early days of HHO technology, many trucks were unable to have fuel savings higher than 22,5% due to the strict parameters of their computer management systems. These trucks have electronic fuel injection with advanced ECUs (Engine Control Units with Euro modules IV and V) and some would simply not allow fuel economy to be improved beyond a certain programmed value.
As HHO technology advances, more trucks are now able to benefit despite these ECU limitations. The new Electronic Fuel Injection Enhancer EFIE-DCP is one of the newest products to address these problems and solve the limitations of many modern vehicle ECUs making possible now to have high fuel savings in the most modern trucks and cars.
The EFIE-DCP is the most advanced electronic fuel injection enhancer (EFIE) in the market. It uses OBD Scan Tools allowing the control in real-time of the MAF/MAP sensor (airflow sensor) and two oxygen sensors (lambda sensors). With de Digital Control Panel you will be able to check the engine performance by looking at several parameters available:
Any regulations made in the EFIE-DCP can be instantly monitored by looking at the panel and the effect on fuel consumption evaluated. You will no longer need to be making regulations "blindfold" like in others EFIEs available in the market. This means higher fuel savings in your car or truck.
Additionally normal EFIEs just allow one possible regulation point causing some problems because when we are driving we are constantly changing the speed of the vehicule and engine performance. This single regulation position will never match perfectly the performance of your car causing problems because sometimes the engine light to be turned ON or resulting in poor fuel saving results.
To solve this problem our new EFIE-DCP has 4 programs available (4 regulation points) that will automatically be activated depending on the speed of the vehicle:
This means that when you start driving, the first program will be activated and will regulate your MAP/MAF and Oxygen Sensors according to a certain ratio (ex: 10% of signal regulation). When you increase your speed, the next program will be activated and start regulation according to the new driving conditions (ex: 20% of signal regulation) - Automatic Speed Regulation
All these features makes our new EFIE-DCP the most advanced electronic fuel injection enhancer in the market allowing the highest fuel savings possible using hydrogen technology.
According to your installation configuration you need to activate the sensors in order to be able to regulate and change the electronic injection. You may work with the following options:
The EFIE Digital Control Panel package includes the following items:
• ISO 14230-4 (Keyword Protocol 2000)
• ISO 9141-2 (Asian, European, Chrysler vehicles)
• SAE J1850 VPW (GM vehicles)
• SAE J1850 PWM (Ford vehicles)
• ISO 11898 (raw CAN)
You will have the possibility to update the software on the EFIE-DCP according to the software releases of our team. You just need to download the last update and transfer it to a SD memory card. You just need to insert it in the embedded lateral SD Card Slot and reboot the EFIE-DCP. Simple and fast you will have from time to time new features available!
Together with the correct selection of the HHO Kit, we advise the installation of the MAF/MAP enhancer control box in all modern diesel common rail trucks, Euro IV and Euro V.
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1 . What are the fuel savings and advantages using our Hydrogen Technology?
Most users have savings from 20 to 30% in fuel consumption. There are cases of higher results with the HEC Chip in electronic fuel injected cars. Hydrogen reduces fuel consumption by carbom based on fuel to burn more completely and efficiently. Hydrogen also helps to clean the carbon deposits inside the engine. Hydrogen exhaust emissions are pure water. So, you save fuel, save money and save the environment.
2. Is a hybrid fuel system more prone to rust or corrosion?
No. The fossil fuel [gas or diesel] produces enough heat during combustion to vaporize the Hydrogen as it converts back to water and exits the exhaust system.
3. Can this system improve my performance?
Yes, the injection of Hydrogen into your internal combustion engine will assist in cleaning the internal parts as the engine runs. It will increase the torque and horsepower and reduce the hydrocarbon pollutants currently being released into the air through your exhaust. Hydrogen burns faster and cleaner than gas or diesel within your engine. This makes your vehicle run smoother, longer, cooler, and more efficiently than ever before.
4. Does it work with Diesel, Petrol or GPL vehicles?
Yes, it works with all vehicles with internal combustion engines.
5. Does the hydrogen generator cause any short or long term harm to my engine?
No, the hydrogen generator does not cause any problems to the engines.
6. What type of routine maintenance is involved?
Filling the water tank with distilled water as needed. Every 1000 km you will need 1 liter of water and add litle bit of electrolyte. Every siix months, depending on amount of use, it is recommended to drain and flush the system and replace with fresh distilled water and electrolyte catalyst.
7. What is the electrolyte used?
The best electrolyte is KOH (Potassium Hydroxide). Very cheap and easy to find.
8. Will the water in the unit freeze in winter?
No, if you add about 20-25% of isopropyl alcohol to the reservoir solution to avoid freezing in winter months.
9. What if I don't use Distilled water in my generator?
Distilled water is basically pure water. Other types of water like tap water, mineral water, pond water, sea water, etc., will work but they will also quickly cause the electrolyte to become "muddy" due to the minerals and impurities in the water. The muddy electrolyte will build up on the generator plates and act as an insulator causing Hudrogen gas production to suffer. The same is true with many other types catalyst, especially any catalyst containing sodium, like baking soda or sodium hydroxide. Sodium will quickly contaminate the electrolyzer plates and cause the unit to become ineffective.
10. Can the hydrogen generator explode?
No. The hydrogen production is made on demand. You will have hydrogen only when your car is moving. Unlike pressurized gas tanks, there is only a small amount of hydrogen pressure in the system.
11. If I have questions is there any tech support for my Hydrogen Generator?
Tech support is provided for your Hydrogen Generator (firstname.lastname@example.com).
12. Is there any kind of warranty that comes with my Hydrogen Generator?
Yes, 2 years 100% warranty for parts and unit repair or replacement.
13. In case of an accident will the Hydrogen Generator blow up?
Absolutely not, all you will have is water and electrolyte on the ground.
14. Can we use the Hydrogen Generator on a power generator?
The Generator can be used on any power generator.
15. What is the products life?
To date we have units sold for 2 years still operating.


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Zurich, 11 October 2018: FIATA Presidency Member and Rapporteur for Training and Education, Mr. Francesco Parisi, and Mr. Luc De Blieck, Deputy Director Procedures and Facilitation, World Customs Organization (WCO), signed a historical agreement aimed at enhancing collaboration in training and education. The agreement was signed at the FIATA World Congress 2018 in New Delhi, India.
Mr. De Blieck also attended and addressed the opening ceremony of 2018 FIATA World Congress. He reflected on the key drivers that are defining the global Customs agenda and are driving the discourse on the future of international Customs. Mr. De Blieck highlighted that trusted partnerships between Customs and businesses are the cornerstone for tacking future challenges.
The FIATA World Congress serves as an international platform where stakeholders in global logistics gather to voice their opinions and concerns and speak for their sector. It is the best place to discover and discuss the latest developments in international logistics and the freight forwarding industry, new legislations, technologies, and updated guidelines.
The agreement was signed on Thursday, September 27, 2018, during the session "FIATA Logistics Academy (FLA) & Advisory Body Vocational Training (ABVT). The purpose of the agreement is to initiate cooperation between WCO Academy and the FIATA Logistics Academy in the establishment of joint training courses. One of the main objectives is to cooperate towards disseminating Customs e-learning courses, offered by the WCO Academy, to the international logistics community through the network and the website of the FIATA Logistics Academy. A major part of the cooperation between WCO Academy and FIATA Logistics Academy will be directed towards providing Customs e-learning to FIATA's association members. Among others, there is also a mutual intention to organize joint webinars, as well as to offer joint certificates.
The 2018 FIATA World Congress theme was "The Future Starts Here" and this is also certainly valid for the newly established cooperation in training matters, between WCO and FIATA. We are looking forward to the 2019 World Congress in Cape Town, South Africa where you will hear about further developments in this area.
Media Contact:
Hans Gunther Kersten, Director General
Email: kersten(at)fiata.com
About FIATA
FIATA, the International Federation of Freight Forwarders Associations, was founded in Vienna, Austria on May 31st 1926. It is a non-governmental organisation that today represents an industry covering approximately 40,000 forwarding and logistics firms, employing around 10 million people in some 160 countries. FIATA has consultative status with the Economic and Social Council (ECOSOC) of the United Nations (inter alia ECE, ESCAP, ESCWA, etc.), the United Nations Conference on Trade and Development (UNCTAD), and the UN Commission on International Trade Law (UNCITRAL) as well as many other UN related bodies, e.g. the World Bank. It is recognised as representing the freight forwarding industry by many other governmental organisations, governmental authorities, private international organisations in the field of transport and logistics, such as the European Commission (through CLECAT), the International Chamber of Commerce (ICC), the International Air Transport Association (IATA), the International Union of Railways (UIC), the International Road Transport Union (IRU), the World Customs Organization (WCO), the World Trade Organization (WTO), etc.
For further information, please go to: www.fiata.com
Glattbrugg, 11 October 2018

subset: commoncrawl


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To the Honorable Board of Aldermen and Citizens of Dardenne Prairie, Missouri
November 30, 2018
November 30, 2018
To the Honorable Board of Aldermen and
Citizens of Dardenne Prairie, Missouri
In compliance with Section 67.010.1 of the Revised Statutes of Missouri and Section 130.020 of the Dardenne Prairie Municipal Code, I am pleased to present the 2019 Operating Budget for the City of Dardenne Prairie which will come before the Board of Aldermen for approval on December 5, 2018. This budget comprises estimates for revenue and expenditures necessary to operate city government, fund parks and recreation activities, invest in capital improvements, service public debt and maintain a sound unrestricted reserve.
We estimate that as of January 1, 2019, the City will have total reserves of $5.375 Million, of which $4.219 Million will be in the General Fund, $157,501 will be in the Special Revenue Fund, $27,349 will be in the Capital Improvements Sales Tax Fund, and $530,797 will be in the Parks & Storm Water Fund.
The Board of Aldermen adopted a formal policy in 2018 to guide the prudent investment of the City's substantial cash reserves. We will place a substantial portion of the general fund reserve in certificates of deposit and US Treasury instruments to earn much more interest than we accrued in bank accounts in the past.
Projected Revenues in 2019 from all sources are expected to total $4,679,590. Expenses for all activities, including $650,000 in street maintenance and repairs under the County Road Maintenance Contract are estimated to be $3,534,273 which leaves a surplus of $1,145,317 available for capital improvement projects. We have identified $1,193,450 worth of additional Capital Improvements for 2019 for which we will draw $48,133 from the General Fund Reserve.
The major sources of revenue for the City include: General Sales Tax (1%) of about $1.2 million; Capital Improvement Sales Tax (0.5%) of about $600,000; Motor Fuel Tax of about $461,000; Property Tax (10.54 cents per $100 of assessed valuation) of about $309,000; Road & Bridge Tax of about $275,000; Municipal Court Fines of about $190,000; the new Parks & Storm Water Sales Tax (0.05%) of about $600,000. Details are included in the attached budget.
The major expenditures, excluding capital improvements include: Debt Service of about $805,000 (principal & interest on Certificates of Participation; partial rebate of general sales taxes to the Dardenne Towne Center Transportation Development District; and Bryan Road Neighborhood Improvement District); personnel costs of about $806,000; Police Department Contract of $335,298; Road maintenance contract with St. Charles County of about $650,000. Details are included in the attached budget.
We plan to invest about $1,651,000 in capital improvement projects in 2019, to include $458,000 in the Road Maintenance Contract to replace concrete slabs in several subdivisions. In addition, we plan to continue the 10-year program of street maintenance and sidewalk replacements to comply with the Americans with Disabilities Act. We are also continuing the engineering work and right of way acquisition for the Hanley Road Improvement Project. With funds provided by St. Charles County we will engage an engineering firm to study the design and construction of a highway interchange on Route 364 at Technology Drive in Dardenne Prairie. Finally, we will address two chronic problems at the Barathaven Lake and trail which require changes to the way water drains from the lake to Dardenne Creek.
The City's recreation program will continue to expand in 2019. We will complete the Parks and Recreation Master Plan begun in 2018. We also expect to design and construct improvements to the Baseball fields next to City Hall, including an upgrade to the gravel parking lot. We will continue to engage the public in developing plans for additional parks and recreation facilities in furtherance of Proposition P, passed by the voters in November 2017.
The City is striving to save money where possible while still delivering services to the public and prudently investing in the maintenance of the public infrastructure.
ss// David C. Zucker


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Welcome to our website! As we have the ability to list over one million items on our website (our selection changes all of the time), it is not feasible for a company our size to record and playback the descriptions on every item on our website. However, if you have a disability we are here to help you. Please call our disability services phone line at 203-288-2943 during regular business hours and one of our kind and friendly personal shoppers will help you navigate through our website, help conduct advanced searches, help you choose the item you are looking for with the specifications you are seeking, read you the specifications of any item and consult with you about the products themselves. There is no charge for the help of this personal shopper for anyone with a disability. Finally, your personal shopper will explain our Privacy Policy and Terms of Service, and help you place an order if you so desire.
"We beat the big box stores everyday!"
Interior Full-extension Slide-out Drawer With Brackets for Use Inside Any Acr1717 or Acr1718 Refrigerator
Summit ACR17DRAWER
Summit KEY
Regular Price $5.51
Call for Our Best Price
Dual Tap System With Nitrogen Tank To Serve Both Nitro-infused Coffee and Flat Iced Coffee From Most Beer Dispensers
Summit KITCMTWIN
Regular Price $28.75
Call for Our Best Price
28 Bottle Fully Integrated Commercial Wine Cellar Designed for the Display and Refrigeration of Beverages, With Digital Controls and LED Lighting
Summit VC28S
Regular Price $933.80
Call for Our Best Price
51 Bottle Fully Integrated Dual Zone Commercial Wine Cellar Designed for the Display and Refrigeration of Beverages, With Digital Controls and LED Lighting
Summit VC60D
Regular Price $1,209.30
Call for Our Best Price
Basket holder for full or half size Gelato pans available for any flat glass slide top freezer.
Summit GELATOPANHOLDER
Regular Price $57.78
Call for Our Best Price
Summit SSK
Regular Price $62.06
Call for Our Best Price


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15 Minutes to Blu Port, 15 Minutes to the Center of Pranburi, 15 Minutes to Pak Nam Pran, 25 minutes to Sam Roi Yot and 10 Minutes to the beach at Khao Tao. Banyan Golf Course is 10 minutes and most others are within a 30 minute drive maximum.
This is a perfect retirement/Holiday/Rental Home.
Fully furnished, not in a development, very private and extremely secure.
Own water supply, electricity and no maintenance fees. TV via satellite and HSI (True), Broadband Internet (True).
Land approx 398 Sq Mtrs.
The Villa's indoor measurements are approx 120 Sq Mtrs. It has an outdoor covered lounge/dining area at an additional 28 Sq mtrs.
Separate Laundry Room off large Carport, 2.5 Bathrooms, 2 Bedrooms, Lounge and Kitchen.
Fully Equipped and furnished.
Available Freehold or Leasehold.
Priced for a quick sale at 4.490.000 Mil Bht


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PWCC Vault
Welcome to the PWCC Vault! This landmark service has been a vision three years in the making, now fully available to clients for all recent purchases as well as overall collections or portfolios.
The Vault was created to serve the investment-caliber trading card community and is focused on meeting the needs of the larger marketplace. Overseen by secure repository designer Chet Orloff who has extensive experience in the archival of fine art and other high-value collectibles, the PWCC Vault is UL Certified Class 3 and rivals any collectibles archival storage facility in the world. We are proud to offer the PWCC Vault to our clients and hope the experience is as useful as we've envisioned.
Clients of the PWCC Vault enjoy:
- Contents that are fully-insured for the actual portfolio value.
- A bank-style vault rated Class III by the Underwriters Laboratory with state-of-the-art security monitoring and rigorous access control.
- Digital archive of each asset using the finest digital imaging in the market.
- Custom software to securely view, share, fulfill, and sell assets with third parties.
- Sell your items stored in the Vault in our landmark retail offering, the Vault Marketplace.
- Full-scale fulfillment services for all assets in archival.
- Free PWCC Eye Appeal (Above Average, Exceptional, and Superior) evaluation. Applies to cards dated 1986 and older with a market value over $250.
- Free shipping on all purchases from PWCC Marketplace shipped to the Vault
- Waived Archival Fee for single graded cards purchased in a current PWCC Auction and shipped to the Vault
- A line-of-credit using graded items in your Vault portfolio as collateral up to 40% of the market value with competitive interest rates.
- Showcase your portfolio in Cooperstown through the exclusive partnership between the PWCC Vault and at the Baseball Hall of Fame.
- Sell your items stored in the Vault in our landmark retail offering, the Vault Marketplace.
- Easily share items in your Vault portfolio with family, friends, or potential buyer through a sharable link.
- The Vault is located in Oregon, a sales tax-free state. All active purchases shipped with a Vault delivery address will reflect Oregon's 0% sales tax rate. This is true for purchases from PWCC or any other venue.
Services Coming Soon
- Use the vault to house your portfolio as part of your overall estate plan using PWCC's estate management services.
- Leverage the Vault to store your items on the PSA Set Registry and PWCC will provide high-resolution digital images of your portfolio for display on the PSA Set Registry.
- Order a presentation-quality album of your portfolio.
- Compare completeness of sets, collections, and portfolios with other members of the trading card marketplace.
- Donate your collection to a non-profit organization and use the Vault to house the items.
- Archival Fee.
- Graded Cards – 1% of insurance value is charged at intake of assets (minimum fee of $2 per asset and a maximum fee of $100 per asset). Note: completely-graded sets, mixed-grading-company sets or sets registered with PSA, SGC, and/or Beckett use the same ingestion process as single graded cards.
- Ungraded Cards – 1% of insurance value is charged at intake of assets (minimum fee of $10 per asset and maximum fee of $100 per asset).
- First-Year Storage Fees. 0.5% of insurance value will be charged for the first full year, billed monthly. The remaining fees for this first year will charged if items are removed from the Vault during the first year, but it will be prorated if items are sold mid-year through a PWCC Marketplace.
- Long-Term Storage Fees. 0.25% of insurance value will be charged for the second and subsequent years of storage. These fees will be billed monthly and will be prorated for the actual duration of service.
New PWCC Headquarters and Vault Construction
Join the Marketplace
Create an account to join our mailing list and gain full access to our suite of investor tools, including the PWCC Indices, the Market Price Research tool, and Auction History sales database as well as full access to our Marketplaces.
Sell on the Auction Marketplace
PWCC manages the largest trading card auction venue in the world, comprising 12 annual auction events which run every month of the year. Each event consistently features some of the finest trading cards in the world in an easily-surveyed format that reaches both hobby and investment minded clients alike.


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Seattle Courthouse Wedding of KC and Ben
August 16th, 2016
They made it legal.
KC called and said she wanted to have a simple wedding and that is what she got. KC and Ben were married at the Seattle Municipal Courthouse on Friday July 15, and then went for dinner at Ray's Boathouse.
Their family were the only people in attendance and it was a wonderful wedding indeed. The weather was perfect and so was every detail. The dinner at Ray's Boathouse was delightful. Here are some of the pictures I chose to highlight the day. Best of luck to the happy couple.
Here is a link to the web gallery with all of KC and Ben's wedding pictures.
Here is a link to the web gallery with all of KC and Ben's wedding pictures.
Below is a slide show with a more complete set of wedding photographs from KC and Ben's wedding. Click on toggle thumbnails to hide them; to start just click on the right arrow on the image.
Amber and Christina Courthouse Wedding Photography Preview
August 14th, 2013
Christina and Amber have been together for 14 1/2 years and last weekend they went to the King County Courthouse in Seattle and made it legal in front of a judge. Here is a preview of some pictures from their wedding last weekend. More to come later.


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Upon the disestablishment of the 65th Aggressor Squadron from Nellis AFB, the F-15 aircraft attached to that squadron were transferred to various USAF ANG squadrons. The 144th FW of the California ANG acquired these aircraft as replacements for their F-16Cs.
A handful of these aircraft carried the aggressor paint scheme before waiting for their repaint to the traditional Mod Eagle scheme. We've captured two of these aircraft on this decal sheet.
There is one set of stencil data on this sheet.
Sized for the Tamiya F-15C kit.
Recommended Kits:


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What!? What about the obvious evidence presented with quality images? What's going on here?
The problems are so serious that Lee Smolin, a physicist at the Perimeter Institute in Canada, has written a book in which he makes it clear "The problems are rooted in the way the career and funding structures of the academy reward me-too science, lack of courage, entrenchment of failed research programs, legacy building, empire building, narrowness, defensive strategies and groupthink."
Meanwhile, this website
remains steadfastly dedicated to presenting
"Gateway" webpage to the game-changing evidence
—incontrovertible and devastating evidence:
–C. Ranzan (2015-10-15)
The World is changing. Witness the on-going social revolution, succinctly described as a full-blown orchestrated decline of Western nations. The devious and highly effective divide-and-conquer strategy of the New World Order continues to be implemented; and the predictable nightmare of Marxist multiculturalism continues to unfold.
Press Release (2017 December 30):
"Physics desperately needs not new ideas but new facts. Discoveries, not inventions. Ideally, physicists will stumble on something so startling that they abandon their pursuit of multiverses, strings and other fantasies and return to reality." –John Horgan, teacher and science writer. [Source]
Exactly. Facts are needed to return us to reality. And the new fact is that the Sachs-Wolfe effect has no foundation —it is not real.
The Sacks-Wolfe Effect has been disproved!
The last Pillar of the Big Bang has collapsed.
The Expanding-universe cosmology has no valid scientific support.
Here is the link to the Sacks-Wolfe-disproof article. ... This is simple enough for the layperson. So don't let the math discourage you. Some of it is merely basic algebraic addition and subtraction. Most of the math is not even necessary; it merely gives the presentation a scholarly flavor. Just know that the underlying logic is simple —a foolproof and compelling argument presented with the aid of various figures (14 in all).
Supplementary: A good description and illustration of the Sachs-Wolfe effect
may be found in the cover story of Scientific American (the 2016 August issue),
"The Emptiest Place in Space" by István Szapudi.
–C. Ranzan (2017- December)
Ref.#1. C. Ranzan, Sachs-Wolfe Effect Disproof –The fundamental
flaw in the spectral analysis of gravity wells, International Journal of
Astrophysics and Space Science,
Vol.6, No.1, 2018, pp.1-17 (Abstract
& links.)
(Doi: 10.11648/j.ijass.20180601.11 )
Ref.#2. C. Ranzan, Cosmic Redshift in the Nonexpanding Cellular Universe, American Journal of Astronomy & Astrophysics, Vol.2, No.5, 2014, pp.47-60. (Doi: 10.11648/j.ajaa.20140205.11)
Ref.#3. C. Ranzan, Olbers' Paradox Resolved for the Nonexpanding Infinite Universe, American Journal of Astronomy and Astrophysics Vol.4, No.1, 2016, pp1-14. (Doi: 10.11648/j.ajaa.20160401.11)
The Mechanism driving astrophysical jets has been discovered
The mystery behind the source of ultra-energy particles
has been resolved
Approved for journal publication, a new DSSU research paper addresses some long-standing questions:
What drives astrophysical jets? What process or mechanism generates the stupendous power of those spectacular emission jets associated with certain compact stars? Even the energies of the individual particles are mind-blowing. The emissions include gamma photons and neutrinos with energy equivalent to a million hydrogen atoms!! Imagine that much energy contained in a single gamma photon or a solitary neutrino!
The causal driver has been one of the biggest mysteries of the universe —one that has baffled the academic cognoscenti for decades.
The DSSU paradigm now brings to astrophysics a new mechanism by which a gravitationally collapsed body produces energy —the energy that feeds emission beams and then drives polar jets.
Traditionally, energy-extraction theories fall into two categories:
First category. The energy is extracted from external magnetic fields —generated by the rotation of an accretion disk diffused with charged particles. An example is something called the Blandford–Znajek process. Its major weakness is its inability to explain the presence of jets for objects that have no accreting mass.
Second category. The energy is extracted from the rotation of the collapsed body itself. The logic here is that the angular momentum (the energy of the rotation) of the black hole's mass is conveyed to the external world by way of frame dragging. Then the external environment responds by somehow producing jets. An example is the Penrose mechanism. The fatal weakness of this hypothesis is its inability to explain the presence of jets for objects that have negligible rotation.
Both extraction methods fail to explain the truly extreme energy, the ultra-energy particles.
Now there is a third way. While the traditional methods all require that radiant energy be generated in the external environment, the DSSU approach has radiant energy emanating from within!
|Table 1. There are only three basic ways to explain the energy source for the jets associated with critically-collapsed stars (commonly called stellar black holes).
Explanatory Theory
Source of Energy
Traditional view requiring an ACCRETION DISK:
Magnetic fields associated with the dynamics of an accretion disk surrounding a stellar black hole.
Various complex relativistic and electromagnetic effects involving the rotating disk and its charged particles.
Problem: FAILS to explain the jets of disk-free objects.
Traditional view requiring significant ROTATION:
Energy is derived from the rotation of a black hole. This would have to be the energy of the mass's angular momentum. The rotation causes frame dragging, which then somehow causes jets.
The frame dragging is caused by the rotation of the singular mass; but there is no plausible explanation of how a singularity —a point mass of zero dimensions— can possess angular momentum or rotational kinetic energy!
Superneutron Star
(DSSU theory):
Processes WITHIN the Superneutron Star; inside the "event horizon."
Generation mechanism: Velocity differential blueshift acting on photons and neutrinos.
Escape mechanism: via bipolar magnetic portals.
Most profoundly, the new approach is a mechanism whereby energy is released from INSIDE a totally collapsed gravitating body (misleadingly called a stellar black hole). The result of recent research into the DSSU, it is the only such mechanism ever devised without violating the laws of physics and without incurring infinities. DSSU theory offers the first and only method for powering jets that does not require rotation or an accretion disk.
The latest research paper under the DSSU paradigm delivers another devastating blow to conventional physics and astro-science.
■ First compelling explanation of the mechanism powering astrophysical jets.
■ First reality-based explanation of the energy source when there is no spin, no accretion, no disk —when conventional theories fail.
■ Details the mechanism for the generation of ultra-energy gamma particles and Peta-eV-energy neutrinos (neutrinos having 1,000,000,000,000,000 electron volts of energy!).
■ The first and only theory for the emission of energy from the inside of a totally collapsed (gravitationally collapsed) structure.
■ And as the followers of DSSU theory have come to expect, the explanations are perfectly natural; the concepts are straightforward, the arguments logical, the conclusions compelling, the implications profound.
The details are contained in the revolutionary article* —Natural Mechanism for the Generation and Emission of Extreme Energy Particles by C. Ranzan— published in Physics Essays Journal in the 2018 September issue. According to the PE Reviewer: "This is a scholarly and erudite article that deserves to be published in recognition of its tutorial nature and … the validity of the author's proposals."
DOI link: http://dx.doi.org/10.4006/0836-1398-31.3.358
FREE Reprint: Download PDF *
* Reprinted by permission of Physics Essays Publication, from Physics Essays, Vol.31, No.3, p358-376 (2018).
–C. Ranzan (2018-8) Back to Top
For the first time in history, the diverse manifestations of gravity are brought together by one surprisingly simple process.
The new research paper, entitled The Nature of Gravity –How One Factor Unifies Gravity's Convergent, Divergent, Vortex, and Wave Effects, details the unification of the various aspects of gravity. It also presents a remarkable new development in the theoretical nature of gravity waves and proves the existence of a strict limit on the centrifugal effect.
Ongoing research into DSSU Theory has uncovered a way, a perfectly natural way, to bring all four (five if the primary cause is included) manifestations of gravity together under the "aether" umbrella —under the distinct aether that serves as the foundation of DSSU theory and DSSU cosmology.* Unified by a simple factor (a two-sided process) are, two primary manifestations, and two secondary effects, and acoustic-like gravity waves.
Here is a brief description of the gravity effects:
(1) Convergence gravity. This is your normal everyday gravity. It includes Primary gravity associated directly with mass AND Secondary gravity associated only with the convergent gravity field.
(2) Divergence gravity. This is what Einstein called Lambda (the cosmological constant) and popularly known as cosmic antigravity.
(3) Vortex effect. This is best described as a spiral-motion amplification of gravity. It manifests in the region around significant rotating structures.
(4) Gravity waves. These are acoustic-like effects conducted by the universal space medium.
In each and every case, the energy involved can be linked to aether.*
Yes! Linked to the universal space medium —but not in the way that others have been attempting for centuries.
The Vortex effect, it turns out, has profound implications for understanding spiral galaxies —for making sense of their rotation curves. As noted in (3), the effect acts as a booster of gravity; this, in turn, makes it appear as if there is significantly more mass present than what astronomers actually observe, or estimate to be there. It is quite elementary to see how this gravity amplification makes the invoking of "dark matter" entirely redundant.
However, the strangest implication to emerge from the research into the Vortex effect must surely be the diminishment of the centrifugal effect. Here was yet another gravity-amplifying mechanism. Following the carefully constructed logic and taking the Vortex effect (often called the frame-dragging effect) to its ultimate conclusion, it was found that the centrifugal effect totally vanishes! It was a stunning conclusion. Under the given conditions, the rotation rate of a gravitating body has no upper limit!
--- The research reveals how, in the real world, the centrifugal "force" depends on the rotation speed through aether —and how Nature has a way of reducing that speed (via the mechanism of aether drag), even to the extent of entirely cancelling all centrifugal manifestation.
Last on the list is gravity's acoustic aspect. And here again the investigation revealed something unexpected but unavoidable. In a surprising development, it was found that gravity waves fall into two categories of waves —only one of which carries defined energy.
Summary Table of the major stresses to which the universal medium is subjected.
Primary stress
(Concentrated stress)
Secondary stress
(on surrounding aether)
Tertiary stress
(across cosmic Voids)
Torsion stress
(Shear stress)
Manifests as MASS (& energy particles) —the PRIMARY ABSORBER of aether
Manifests as negative aether strain:
Manifests as positive aether strain:
Manifests as negative aether strain:
More SELF-DISSIPATION
PRIMARY CAUSE of GRAVITY
A unique aether theory of gravity —based on DSSU's dynamic aether— has been developed to explain the several guises of gravity. The convergent, divergent, vortex, and wave effects all have one thing in common: They all result from the stress-induced change in quantity of aether.
The opportunity this presents is nothing less than revolutionary. It opens the door to a new level of understanding our Universe.
And, for the benefit of all the spectators and participants in the ongoing search for truth and reality …
For the benefit of all those still struggling with the preposterous big-bang hypothesis …
For the benefit of physicist Janna Levin who has been optimistically searching, since at least 2001, for an answer to the most pressing question dealing with gravity,
"Is there a theory beyond Einstein's that will avoid the ugliness of infinite singularities; a theory that can handle … black holes without becoming singular? … We're inspired by the predictions of relativity to look for an even greater theory, a theory that looks like Newtonian gravity when gravity is weak and looks like general relativity when gravity is strong, but may look entirely different when gravity is strongest."**
For the benefit of all those seeking to expose the foundationless big-bang hypothesis and other unscientific cosmologies …
… here is the icing on the cake:
DSSU gravity, based on a subquantum medium, encompasses a full range of manifestations —from autonomous cosmic-scale gravity domains, down to the maximum compaction and intensity of terminal-state neutron stars— without ever becoming singular. In other words, there is no black-hole paradox.
LINKS to the abstract and the full Article at the International Journal of Astrophysics and Space Science:
The Nature of Gravity –How One Factor Unifies Gravity's Convergent, Divergent, Vortex, and Wave Effects.
DOWNLOAD Reprint of Article: PDF file.
* Unfamiliar with DSSU aether? Here is a quick overview:
DSSU aether is a nonmaterial substrate consisting of discrete subquantum entities (pulsations). It possesses no energy when in a static state. Yet its presence is essential for manifesting energy —any and all forms of intrinsic energy. The energies associated with gravity are the most immediate examples in the context of this article.
** J. Levin, How the Universe Got Its Spots (Weidenfeld & Nicolson, London, U.K., 2002)
–C. Ranzan (2018-12) Back to Top
Awesome astrophysical mechanism for the amplification of energy has been uncovered.
Following several years of research, it is now understood how Nature is able to extract energy from the universal space medium (aether). What has been uncovered is a fundamental mechanism whereby limitless energy is extracted from nonmaterial aether. Sounds bizarre, but is supported unambiguously by the science. What is so remarkable about this process is the fact that it does not require the universal space medium to possess energy. Let me make this absolutely clear, energy is extracted from the aether, yet the aether itself contains NO energy! It is a stunning finding.
The process can be easily understood. Based on the spectral shift caused by a velocity differential of aether flow, it is as straightforward as changing the wavelength of light. It is just the opposite of what is familiarly known as redshift.
The process is enormously powerful. The profusion of the energy that emerges staggers the imagination … 1000 times more powerful than anything (mass or energy particles) produced by CERN or any other particle accelerator.
Then there is the considerable breadth of applicability: The process plays a crucial role in resolving five of the greatest mysteries in astrophysics.
■ The great mystery of stellar black holes. The energy-extraction Mechanism exposes the black hole singularity as an obsolete and untenable concept.
■ The mystery of electromagnetic radiation bursts. The Mechanism explains how energy extracted from aether contributes to the cosmic source of electromagnetic radiation bursts (ranging from radio to gamma frequencies).
■ The mystery of the ultra-energy neutrinos. This is resolved by revealing how ordinary neutrinos undergo a vast amplification, thereby generating the most potent energy particles in the universe.
■ The mystery behind astrophysical jets. This is resolved by providing the veritable source of the driving energy.
■ The greatest mystery of them all. The energy-extraction Mechanism solves the mystery of how Nature transfers energy from the interior of an end-state collapsed star —from the forbidden side of the lightspeed boundary (conventionally called the event horizon).
For the record, a totally revolutionary
feature: The energy is extracted from the space medium (aether) yet this
space medium itself has NO MASS and NO ENERGY! … Furthermore, the amount
of energy that can be extracted is limitless!
Published in Infinite Energy Magazine (2019 March/April) is the fascinating story [1] of how a totally collapsed (gravitationally collapsed) body —a type of neutron star best described as a terminal-state star— takes in comparatively low energy radiation particles and spews out high-energy and ultra-energy radiation particles, namely photons and neutrinos.
It is the story of the universe's most powerful, most prodigious, energy amplifier. The published article reveals how aether is able to generate and amplify energy. Described is a process whereby low-energy CBMR energy is converted to gamma radiation and ultra-energy photons —and neutrinos with energy far beyond anything ever produced by Man's particle accelerators.
Take a moment and reflect on the profound implications, both scientific and philosophical, of what has been uncovered [1] [2]: We are now able to recognize, at a fundamental level, what regenerates the energy of the Universe. We are now able to comprehend the mechanism by which the Universe perpetually regenerates its energy! —even to fathom how the Universe perpetually regenerates itself !
–C. Ranzan (2019-3)
Ref [1]: C. Ranzan, Nature's Supreme Mechanism for Energy Extraction from Nonmaterial Aether,
............. Infinite Energy Vol.25, Issue#144 (2019 March/April). Reprint PDF
Also see the related article:
Ref [2]: C. Ranzan, Natural Mechanism for the Generation and Emission of Extreme Energy Particles,
............. Physics Essays Vol.31, No.3, pp.358-376 (2018). (Doi: http://dx.doi.org/10.4006/0836-1398-31.3.358) Reprint PDF
Back to Top
The latest DSSU research extends Einstein's relativity theory in a way that makes possible the 100-percent conversion of mass to energy WITHOUT involving matter and antimatter annihilation.
Moreover, the easy-to-understand new (and more inclusive) interpretation of mass and motion resolves paradoxes associated with conventional black holes.
Essentially, this article† shows: How to use basic relativity equations to explain mass-to-energy conversion. It provides the mathematical support for the recently discovered astrophysical mechanism that powers Terminal-star jets (popularly called "black hole" jets). More specifically, it details the theoretical foundation of the total conversion of mass to energy without invoking matter-antimatter annihilation.
The proof: If you like mathematical arguments, a basic algebra proof is presented in step-by-step detail. If averse to mathematical reasoning, no problem; a straightforward graphic/diagrammatic sequence works just as well. Either way the logic is foolproof; the conclusions compelling. What this means is that we now have the theoretical underpinnings for the recently discovered mechanisms detailed in two previous articles:
■ Natural Mechanism for the Generation and Emission of Extreme Energy Particles, Physics Essays Vol.31, No.3, pp.358-376 (2018). [Reprint]
■ Nature's
Supreme Mechanism for Energy Extraction from Nonmaterial Aether, Infinite
Energy Vol.25, Issue#144 (2019 March/April). [Link to Issue#144]
A precedent for DSSU theory. For the first time, it is being published in a journal dedicated to high-energy physics. The periodical is the Journal of High Energy Physics, Gravitation and Cosmology. The article title is "Mass-to-Energy Conversion, the Astrophysical Mechanism."†
Highlights of the article detailing the new interpretation:
■ The presentation uses relativistic motion and mechanical energy equations, combined to form a simple energy triangle; and then the triangle is manipulated to explain mass-to-energy conversion. It's as simple as that. With a child's play manipulation of triangles the standard and new interpretations are clarified and compared.
■ Exploited is the enormously important distinction between apparent and intrinsic aspects: including motion, momentum, kinetic energy, and total energy.
■ Recalled is Sir James Jeans prescient insight from the 1920's into how the process of mass conversion (to energy) is merely that of "unbottling" imprisoned wave-energy and setting it free to travel through space.
■ Implemented is a three-part strategy to accomplished TOTAL
mass-to-energy conversion:
1. Make the motion relative to the universal space medium. This allows the introduction of the concept of intrinsic energy (total, kinetic, and mass energies) as counterpart to the apparent version.
2. Recognize that a particle's mass property diminishes with increase in speed. This means introducing the concept of intrinsic mass (which varies with intrinsic speed).
3. Impose a change in the particle's gravitational environment. Instead of applying an electromagnetic accelerating force/energy in order to alter the particle's total energy, there is simply an environmental change.
■ Explored is the remarkable consequence of this mass-to-energy conversion and the associated limitless energy-amplification process. When combined, the two processes lead to a compelling explanation of the mechanism driving astrophysical jets.
■ Followed is a conceptual trail that starts with "unorthodox"
relativity and "bottled" energy, takes the reader along a natural course
through to limitless power, and finally leads to stellar astrophysical
jets. All in all, another great success for DSSU theory.
And so, the revolution in cosmology continues …
–C. Ranzan (2019-4)
† C. Ranzan, Mass-to-Energy Conversion, the Astrophysical Mechanism, Journal of High Energy Physics, Gravitation and Cosmology Vol.5, No.2, pp.520-551 (2019). [Reprint]
Back to Top
First, some background into what led to a remarkable new feature of special relativity —a feature dealing with the nature of intrinsic-motion length contraction. It relates to a previous research paper, into DSSU theory, entitled Mass-to-Energy Conversion, the Astrophysical Mechanism (revolutionary in its own right). In the conclusions section of that work, it was stated,
"Unexpected implication. After completion of the main body of this article and the write-up of the various, mostly self-evident, implications, there emerged an additional ramification. At first it was just something incidental, then it became an annoyance. However, it could not be ignored. What it revealed was so unexpected, so logically inevitable, and so deeply profound, that a simple assertion of this implication would fail to do it justice and, in the absence of full and proper context, may risk sounding scarcely credible. Decidedly, it demands a proper exposition. It will be the subject of the next DSSU research documentation."
It turns out that while atoms undergo physical length contraction (as detailed in the Part 1 article from 2013) the subatomic particles, the electrons, protons, and neutrons actually undergo elongation! This is the stunning conclusion of the newly-published "Part 2" article. While the electron's atomic orbit contracts (as expected when there is significant motion), the electron itself elongates!
The new interpretation —the aether-referenced elongation of fundamental particles— provides a remarkable fit to the reality. (i) It facilitates the conservation of intrinsic energy. (ii) It incorporates the decrease of mass (intrinsic mass) with increased motion (with respect to aether). (iii) And provides the key element in the mechanism of mass-to-energy conversion. A noninteraction-hundred-percent conversion (i.e., no particle-antiparticle annihilations involved). (iv) Furthermore, it precludes the formation of singularity-type black holes.
The new interpretation solves the paradox inherent in black hole physics —the paradox of having infinitely dense mass inside an infinitely small domain.
The following Table summarizes the main points and the benefits to physics of incorporating the concept of elongation.
Arguments in support of elongation (of fundamental particles)
Why it is important
1. If elemental particles did not elongate and contracted instead, it would lead to a major problem —their mass (by definition) must increase. But such increase is contrary to the evidence.
■ Avoids the mass-increase pitfall (as detailed in Natural Mechanism for the Generation and Emission of Extreme Energy Particles, Physics Essays Vol.31, No.3, 2018; page 372).
■ Conformance to physical reality —mass simply does not increase with motion.
2. Conservation of total energy (mass + aether-referenced kinetic energy) requires elongation.
Conformance to the total intrinsic energy equation (for total mechanical energy).
3. Facilitates mass-to-energy conversion.
(Total conversion rooted in aether-referenced motion.)
■ Solves the paradox of stellar black holes.
■ Provides the driving energy/force behind astrophysical jets.
The new understanding of intrinsic motion resolves the textbook problem involving the energy of a particle or object undergoing extreme length contraction (due to extreme motion). … The problem can be expressed this way: Where within the orthodox picture does the energy go, if the particle, atom, or object becomes a cross-section of itself? Where does the mass-energy go when the thing has no volume, when it exists only as a cross-sectional area and no thickness dimension? Where indeed!
Under the traditional view combining unrestricted length contraction and energy conservation has always been problematic. Because of this, the long-standing rule has been that a mass particle/object can never attain lightspeed. And that rule, in turn, has led to a failure to understand the nature of the strangest objects of the Cosmos —Terminal neutron stars.
But now, by understanding the nature of aether-referenced motion, the conflict between mass energy and mass contraction vanishes. The problem of energy being squeezed within a "cross-section" simply does not arise.
The article also addresses this question: What happens to mass particles during a gravitational collapse and these same particles end-up within a no-escape zone —within the most extreme gravitational environment Nature has to offer? Within this extreme environment particles are subjected to the ultimate speed of aether flow.
The discussion focuses on the electron. The standard argument is that "for an electron, it is theoretically impossible to obtain the speed of light." But there is a situation where an electron finds itself being placed into a lightspeed environment —of a gravitational kind. So, what happens? An electron, of course, cannot travel at lightspeed; so therefore it must transform into a massless particle —it must transform into a pure energy state. … The new interpretation of length "contraction" explains how this comes about. □
Publication details and links:
C. Ranzan, Physical Nature of Length Contraction (Part 2) How the Electron Elongates While Its Orbit Contracts, International Journal of High Energy Physics Vol.6, No.1, pp.1-12 (2019).
Abstract & link to PDF document.
Link to Journal (IJHEP): http://www.sciencepublishinggroup.com/j/ijhep
–C. Ranzan (2019-6)
The year 2015 marked the 100th Anniversary of the founding of the theory of gravity called General Relativity —the theory upon which Universal-Expansion cosmology is based. In 1915 was born the theory that became, in 1917, the mathematical foundation of single-cell cosmology. And it was later modified to serve as the bedrock of the Big Bang hypothesis —the speculative idea that the Universe exploded in the past and is currently expanding!
In the milestone year of 2015 the Old and the New cosmologies collided. The New exposed the fatal flaws of the Old. It was the year in which all whole-universe expansion models —this means all General Relativity Universe models— became untenable. They lost their validity. The century-long experiment of extending Einstein's brilliant local-gravity theory to encompass the entire Cosmos had failed. … The unrestrained extrapolation of what was primarily a mathematical theory had flunked the test of reality.
With the publication of the definitive resolution of a long-standing mystery of our age —the greatest structural mystery in astronomy and astrophysics— the Expansion models have forever lost their scientific credibility.
Welcome to the nonexpanding Dynamic Steady State Universe!
–C. Ranzan (2015-12) Back to Top
NOTE: In the video, the Z-index (a redshift number) is being interpreted as a "time" parameter of an evolving universe in conformity with the big-bang expanding-universe paradigm. However, in actuality, the Z-index is essentially a cosmic-distance parameter. The objective reality is that the Universe does NOT expand (only regional space expands). The Universe does NOT evolve (only subsystems evolve). The Universe simply IS. As Heraclitus, some 2500 years ago, wisely taught, This Universe always has been, is now, and always will be … (Fragment #29)
As for the cell structure that manifests as The Cosmic Web: In the DSSU, the cosmic cell structure is NOT phenomenological. It is NOT a phenomenon of the evolution of the universe; rather, the cell structure is fundamental and intrinsic.
–C. Ranzan Back to Top
Conrad Ranzan (2008)
"We have to return to this foundation and start over again asking ancient but fundamental questions
hoping that today we are in a better position to answer them." –Dr. Johan Masreliez
"Beneath the apparently haphazard motions ... may lie a formative tendency
toward simplicity of form, order and regularity." –Lancelot Law Whyte
Finding that the case for cellularity is overwhelmingly convincing we are led to ponder why the astrophysicists and cosmologists of the 20th century failed to adopt the concept as a key feature of the Universe. Think about it: Intrinsic cellularity implies some sort of regularity, some sort of orderly arrangement; but if the opposite, chaos and randomness, is the guiding principle of one's cosmology then grand-scale order makes little sense. If the Big Bang is part of one's belief system, then entertaining the idea of systematic cosmic patterns is strictly heretical.
The experts of the 20th century blundered —badly. They knew the World was a cosmos of dynamic space; they knew that, since "space" is not nothingness, it has to be "filled" with a dynamic space medium; they knew these things on the acknowledged authority of Albert Einstein. In fact, these essentials were known as early as 1839 when when the French polymath Augustin Cauchy (1789-1857) proposed the very first dynamic space medium, an aether-like medium that had the ability to contract. And whatever has the ability to contract surely has the countering ability to expand (this was later confirmed by Einstein's theory of gravity).
In any case, the experts were faced with a basic choice: There were FIVE ways the space medium of the Universe could be dynamic. They extensively investigated four categories of "dynamics." In the end, they settled on one —the consensus was that there is a universal expansion of the space medium. And so, with the some extraordinary extrapolation the 20th century became the age of EXPANDING universe models. ... However, in making the choice, they missed the FIFTH way!
Yes they did. Unbelievable as it may sound, they failed to see what they could easily have seen. In fact, they failed to see what they should have seen because it is well within the domain of the foundation principle of all modern cosmology!
Now why does all this matter?
Well, it turns out that the expanding-universe models don't work. The steady-state expanding models don't work; and explosive expanding models (think Big Bang) don't work. All are problem plagued constructs.
It matters because the real Universe is cellular —it is innately, stably, provably, cellular.
It matters because the consequences are revolutionary.
LINK to the complete essay:
There are five possible combinations of vacuum expansion and contraction. Each combination defines a category of universe models. ... Only one leads to a consistently problem-free cosmology.
2014 10 www.CellularUniverse.org
Copyright © 2005-2020
All rights reserved.
|C. Ranzan
|Site updated: 20-02-29


text:
Data analytics in the cloud
Data analytics in the cloud
Data analytics in the cloud
Project goal
This project is testing and prototyping solutions that combine data engineering with machine-learning and deep-learning tools. These solutions are being run using cloud resources — in particular resources and tools from Oracle Cloud Infrastructure (OCI) — and address a number of use cases of interest to CERN's community. Notably, this activity will make it possible to compare the performance, maturity, and stability of solutions deployed on CERN's infrastructure with the deployment on the OCI.
Project background
Big-data tools — particularly related to data engineering and machine learning — are evolving rapidly. As these tools reach maturity and are adopted more broadly, new opportunities are arising for extracting value out of large data sets.
Recent years have seen growing interest from the physics community in machine learning and deep learning. One important activity in this area has been the development of pipelines for real-time classification of particle-collision events recorded by detectors of the LHC detectors. Filtering events using so-called "trigger" systems is set to become increasingly complex as upgrades to the LHC increase the rate of particle collisions.
Recent progress
The project launched at the end of 2018. We began by developing and porting data pipelines — related to data-analysis and machine-learning use cases of interest — to the cloud (Kubernetes). The workloads had originally been developed to run on CERN's Hadoop and Spark infrastructure.
Next steps
In 2019, the project will investigate two main use cases. Firstly, the replication of data-reduction systems employed at the CMS experiment, with a view to exploiting the scalability of OCI to improve upon current performance. Secondly, the deployment of specific training of the models on OCI using GPUs to test the performance limits of such models on cloud-native solutions. The training models in question are those detailed in the paper listed under publications.
- T. Nguyen et al., Topology classification with deep learning to improve real-time event selection at the LHC, 2018. http://cern.ch/go/8trZ


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Head of Hywind development, Equinor
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[Free Module]Revws - Product ReviewsRevws - Reviews module This topic is here to offer support for revws module. Continuation of this topic Links Download: you can download this module here Demo: you can test revws module on my demo account Front Office / Back Office Bugs and feature requests: if you find any problem, or if you would like to see some new functionality, please add it to issue tracker on github. Additional resources revwsrecent - very simple module to display recent reviews in tab on your homepage
block bannerYou know what I would like to see in the block banner module? Don't guess....I'll tell ya... 😉 I'd like the ability to upload multiple banners and the settings to go with it, and have the system randomly pick one to display.
Amazon Pay by Patworx - Error on Install
SeaSky posted a question in Module helpHey, I've been reading this post about Amazon Pay and thought to give it a go, but after the install when I try to open the module I get an error. I was wondering that if the module worked (post is from 2017), the problem may be with my specific installation or it may be a problem related with the new version of the module / TB? Module Version 2.3.0 for P.S 1.6 (https://addons.prestashop.com/en/payment-card-wallet/21293-amzpayments.html) TB Version 1.1.0 Any help or advice would be apreciated! Error:
[Free Module] Send Review RequestI don't know if anyone wants something like this, or if it will fit the bill or not. I added a module to the thirty bees store called Send Review Request. It will send an email to the customer, who bought an item on your store, asking for a review. You can set what order state you want this to happen at, and also now many product links it will send. So if you bought 12 items, but you have the module set to only show 6, it will only show them the first 6 items they bought. You can get it on github also, if you dont feel like getting it from the store for some reason.
[Free Module] Birthday GiftI dunno if anyone needs anything like this, but I just release another module, this one is called Birthday Gift. You can find it on the thirtybees store here, or on github directly here. It will send an email out to a customer who has a birthday today. You can also choose to make a discount voucher as well. You can run it as a cron job everyday, so it will be automatic, or you can run the link manually.
Login as customerHi everyone, I needed a way to log into my frontend as one of customers. Because I couldn't find any module that would work correctly on thirtybees, I've build my own. I have decided to release it as an open source / free module. So, if anyone need this functionality, you can download it on my store. url: https://store.getdatakick.com/en/modules/login-as-customer github: https://github.com/getdatakick/loginas
how to add some custom css to module?hi there i'm new to bhirtybees i come from prestashop how can i add some custom css without losing it during upgrade? i need to edit some cssinfo module and i don't want do loose it during upgrade is there any way to do it?
CloudFlare GeoIP moduleWhen visitors first come to your store, thirtybees tries to detect country and currency. It uses browser's language to do so, but this method is not very precise. Alternatively, you can enable build-in geoip functionality and use maxmind geoip database to detect country based on IP address. Unfortunately, thirtybees uses legacy (no longer supported) version of this database, so it has become outdated. If you are using Cloudflare in front of your server (as I do), you might know that cloudflare do GeoIP translation and sends this information to your thirtybees server in custom HTTP header. I don't know what database they are using, but I would it's some very expensive and up to date solution. It would be insane not to utilize this information. So I've developed a very simple module that uses this http header to set up customer's country and currency. It does so only on first pageview, when cookie does not exists yet If you are using cloudflare as well, you can download and use this module for free: Cloudflare GeoIP
stats module bug multistore
smarterweb posted a topic in EnglishIf you check best selling products in the stats module, it only shows stats for one store, does not give me any stats for another store. possibly a bug? can anyone confirm this?


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The Oaxaca coast is full of different cove beaches and towns. The unique thing about this coastline is that every Oaxaca beach and town has a totally different vibe, so you can find a place for any type of traveler or travel style. So this Oaxaca coast guide is going to break down the best beaches in Oaxaca so you can find the best fit for your next vacation.
If you are looking for an immersive and hands-on Oaxaca food experience – join our April retreat + food experience – Milpa + Mesa, April 9-13 in Oaxaca city.
We'll be learning from local food experts, participating in traditional methods of planting/preparing/cooking, touring my favorite mezcal palenque, observing local holiday parades, eating some of the best food in the city and much more. More details here! Early bird pricing until February 1st only! $200 off.
Puerto Escondido: Oaxaca Coast Guide
Puerto Escondido is a small city, so this is one of the most developed parts of the coast. However, it's also a real Mexican town, so it has tons of culture to mix in with your Oaxaca coast beach vacation.
Puerto Escondido also has some of the best beaches in Oaxaca, so you can get the best of both worlds – lots of amenities and action, but also beautiful Oaxaca beaches. Check out my full guide for what to do, where to eat and where to stay in Puerto Escondido.
The town has several beaches within it, so I'll break down each one below…
Playa Bacocho: Best Beaches in Oaxaca
Playa Bacocho is one of the best beaches in Oaxaca if you want to have a totally quiet relaxed vacation, but be only a couple minute taxi ride from all the action.
Playa Bacocho is famous for the turtle release that happens every evening during turtle season. This Oaxaca coast beach is beautiful, but not really safe for swimming – so you'll probably want to book a hotel with a pool.
Playa Carrizalillo: Best Beaches in Oaxaca
Playa Carrizalillo is hands down one of my favs and one of the best beaches in Oaxaca. It's a small, but gorgeous cove, filled with turquoise clear water, and an almost perfect and gentle wave.
You arrive at the top of the cliff, so you get an amazing birds eye view of the cove. You will have to descend and climb back up many steps – so this isn't an accessible Oaxaca beach for those with mobility limitations.
This Oaxaca coast beach is safe for swimming, and great for a long day of lounging around. You can also take beginner's surf lessons here, or do SUP.
There are only a couple hotels on the cliff overlooking the beach of Playa Carrizalillo, so most people stay in the little neighborhood just inland from the beach. There are several amenities here, but it's a quiet area, and very quiet at night.
This Oaxaca beach is best for those that want to relax on a beautiful beach all day and have a quiet night. Although it is very easy to take taxis to other parts of Puerto Escondido with more action.
Playa Puerto Angelito/Playa Manzanillo: Best Beaches in Oaxaca
These two Oaxaca beaches are actually in one cove, just separated by a jetty. They are both pretty beaches, safe for swimming, and often filled with locals.
These aren't my favorite beaches in Oaxaca because I think that Playa Carrizalillo is so much prettier, but they are worth a visit and give a glimpse into local life.
Zicatela: Best Beaches in Oaxaca
Zicatela is one of the best beaches in Oaxaca and even the world for surfing – it's famous for its giant and intimidating wave that can get huge during rainy season. They hold international surfing competitions here.
Because of this, there is a strong rip tide and it's not a safe place to swim (at all). But it is a pretty beach with a long stretch of sand and a fun place to enjoy the restaurants and bars.
We've stayed in Zicatela a few times, and I love this Oaxaca coast beach for the vibe. There are tons of great restaurants and bars here – the nightlife is full of energy. There are lots of great hotels here – from nicer hotels to mid-range to basic and very affordable. I have a full guide about what to do, eat and where to stay in Puerto Escondido, with an emphasis on Zicatela & La Punta (the beach below)
It feels part backpackery, part Mexican tourist, and a little bit of everything else mixed in.
Even though you can't swim at Zicatela, you can taxi or hop on a pasajero (the local transportation) to any of the other Puerto Escondido beaches in minutes. We were often paying around 40 pesos per taxi trip within Puerto last time we were there in early 2019.
La Punta/Brisas de Zicatela: Best Beaches in Oaxaca
La Punta is the very southeastern edge of Zicatela beach, but it has it's own vibe.
La Punta is becoming a hip place to stay, so lots of organic shops are popping up, boutiques, and restaurants. You can find some good food here and good nightlife, though it is a bit quieter than Zicatela.
The center of La Punta feels like it's own village, the roads are unpaved, and the feeling is very relaxed and barefoot.
The beach at La Punta is actually safe to swim, though with caution. You'll have to pay attention to the flags and be aware of the current. It can be stronger here than some of the very calm beaches, like Playa Carrizalillo.
La Punta is also one of the best beaches in Oaxaca for surfing, by far. There is a great consistent wave that crashes over the point (la punta), so it's great for intermediate surfers. Lots of surfing classes and surf board rentals are available at this Oaxaca coast beach.
Mazunte: Oaxaca Coast Guide
Mazunte is a little Mexican village on the Oaxaca coast that is famous for it's huge population of sea turtles. There is plenty of wildlife to see here – turtles, dolphins, crocodiles (in mangroves, not on the beach) and whales during the winter season.
Mazunte is one of the best beaches in Oaxaca for the people who like to get off-the-beaten path, but still want to have a few comforts and amenities.
There is one main beach in town that is pretty and has a calm area for swimming. There are also a couple of other pretty beaches within walking distance (Playa Cometa and Playa Mermejita). These beaches aren't safe for swimming but are beautiful and nice to explore.
The traveler type in Mazunte leans young and bohemian. But of course there is still a mix of many types of travelers.
One of my favorite things about Mazunte is the gorgeous park – Punta Cometa. This point jetties out as the southernmost point of the Oaxaca coast. There are easy trails to walk along the cliff and admire the waves crashing on the rocks below. There is a small remote beach here you can explore, and it's also the best place to watch the sunset in Mazunte…and maybe on the whole Oaxaca coast.
If you are heading to Mazunte, check out my full guide of what to do, where to eat, and where to stay.
San Agustinillo: Oaxaca Coast Guide
San Agustinillo is a little town directly adjacent to Mazunte and within 10-20 minutes walking distance, so most things that I've said about Mazunte apply to San Agustinillo too – the access to wildlife, the ability to hike Punta Cometa, etc..
San Agustinillo is even a bit smaller than Mazunte, so it has an even more relaxed and quiet vibe. The traveler type also skews slightly older – with the majority of people seeming to be in their 30s-40s. Lots of couples and young families. We met many creative young couples here from various countries who had interesting jobs or hobbies. Though, again, there is a little bit of everyone here.
There are lots of cove beaches on the San Agustinillo Oaxaca coast that wind around and have rock formations dotted here and there. This is nice because for its beauty but also because it makes lots of different wave and swimming environments – from calm areas to more aggressive waves.
San Agustinillo is one of the best beaches in Oaxaca because it gives you the best of both worlds – quiet and relaxation with lots of amenities close by. If you are heading to San Agustinillo – check out my full guide for the town.
Zipolite: Oaxaca Coast Guide
Zipolite is definitely the best beach in Oaxaca for people who enjoy nudist beaches – because that's just what it is!
But even if you prefer to visit the beach clothed, it's a beautiful beach and a cool little town.
The beach is quite long and guarded on both ends by big cliffs. It's picturesque and a beautiful place to watch the sunset on the Oaxaca coast.
The water extends out shallowly for a long time. It can be a little tricky to swim here, depending on the tide and currents, because the currents are strong. But it's definitely nice for wading, splashing, and enjoying the beach.
The town has a very laid-back feel, but with plenty of little restaurants. The type of traveler here tends to lean European, but I have seen a mix of all ages and backgrounds.
Puerto Angel: Oaxaca Coast Guide
I have only passed through Puerto Angel, but got a glimpse at the town and the beach and have read a bit about it. Puerto Angel is a traditional Mexican fishing village on the Oaxaca coast. The town beach is a good port, so you will see boats docked all around. Still it is picturesque with it's steep cliffs bordering the small cove.
Puerto Angel seems to have less tourism than some of the other towns, so would be a glimpse into traditional Mexican life on the Oaxaca coast.
Playa Estacahuite: Oaxaca Coast Guide
Playa Estacahuite is a tiny cove beach right next to Puerto Angel. I have never been, but have heard it's gorgeous. It's at the top of my list to see next time I visit the Oaxaca coast!
This Oaxaca beach is super quiet with almost no amenities. I believe there might be a couple of simple cabanas for rent and possibly some vacation home rentals. However, it does seem close enough to Puerto Angel that you could easily get back and forth for amenities.
This would be one of the best beaches in Oaxaca to disconnect and enjoy a remote vacation.
Huatulco: Oaxaca Coast Guide
Huatulco is a Oaxaca beach area known for it's big resorts. The town is actually a few minutes inland, and the coastline is dotted with resorts – many all-inclusive.
But the interesting thing about Huatulco is it's completely beautiful 7 Bays. It's a National Park consisting of 7 cove beaches. Some of them are pretty remote and completely empty. We visited one on a road trip once and literally had the beach completely to ourselves. We drove about a half hour down a bumpy dirt road and found a dramatic, beautiful and empty beach on the Oaxaca coast.
Huatulco is the best beach in Oaxaca for those who want a resort experience. But it can also be amazing as a day trip if you have a car. Or if you prefer not to stay in a resort, there are definitely some smaller hotels and more remote areas to stay/explore in this area.
I will keep this list of the best beaches in Oaxaca updated as I plan to return to the coast many more times. And even as our travel style changes I find myself attracted to different Oaxaca beaches on this coastline, which I find telling.
Moral of the story – the Oaxaca coast is super varied and has something for every travel style.
Have you been to any of the beaches in Oaxaca? Which do you prefer?
Tons more posts about the Oaxaca coast and Oaxaca city here, including mezcal, where to eat, where to stay and more.


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[NAME], i think i'm in love with you
I hope I didn't freak you out by my subject line, but I'm really in love with you. Don't worry, it's not in a creepy way. What I mean is I'm in love with your website [COMPANY].
You probably get tons of people everyday who are in love with [COMPANY], so I won't bore you with my reasons. Instead, I thought I could show you some appreciation by giving you some feedback on how you can improve your website.
And if you are wondering how you can repay your biggest fan, feel free to link to my website [MY_WEBSITE]. ;-)
Ah… just kidding, you've already done enough for me by making [COMPANY] so awesome!
Cheers, [MY_NAME]
PS: If you do happen to link to my website [MY_WEBSITE], it will seriously make my year! Maybe even decade!


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"He owns Valentines Day," remarked the lucky wife after her husband used BookVIP to reserve 5-nights at the exclusive Westgate Resort in Orlando. Check out one of the coolest review videos we have seen in a while. These guys know how to enjoy their #vacation.
@BookVIPCom WE were at the #westgateResortsOrlando….It was the bomb… Hope you guys enjoy the video 🙂 pic.twitter.com/tZyeoOHD0y
— Jah Jean-Noel (@JAwesoome) February 15, 2017


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September 16 – 18, 2018 (Schedule)
Learn the latest trends. Network with your peers. Have fun.
Join us at the ASHHRA Conference in Pittsburgh, PA. You won't want to miss our speaking session "Young and Healthy? Why Employers need Preventive Health Programs for Young Adult Workers", presented by Kate Wolin, Chief Science Officer with Interactive Health and Kathryn Foulser, Program Manager for Choose Health Wellness Program at Rush System for Health on Sunday, September 16th at 1:00 PM EST.
This event is full of knowledge, tools and resources to enhance HR success and offers a chance to qualify for CEUs. With over 50 specific health care HR learning sessions, you will return equipped with new ideas to share, cost savings to implement and connections to help streamline everyday operations. Stop by and see us at booth #321.
The ASHHRA 54th Annual Conference & Exposition will be held at the David L. Lawrence Convention Center. A block of rooms has been reserved at two hotels: the Westin Pittsburgh and the Omni William Penn Hotel.
For registration information please click here!
By becoming an Interactive Health member your company could save a yearly


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Congratulations on your admissions to San Jose City College! We are pleased that you will be continuing your educational journey at San Jose City College. Bellow is the Admissions Guide. Note you are required to complete online first and then in-person orientation, both are a requirement for an international student at SJCC!
Your next steps:
Program Specialist
(408) 288-3173
International Counselor
(408) 288-3751


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Xiaomi Launched Redmi 5A In Just Rs 4999 In Flipkart. Flipkart Has Promoting The Tag Line "Desh ka Smartphone" For Quite a Long Time & Now Finally Unveiled Desh ka Smartphone is Redmi 5A.
Xiaomi Launched Redmi 5A In Just Rs 4999 In Flipkart:
Buy All New #DeshKaSmartphone Mi Redmi 5A 2GB+16GB @ Rs.4999 Only And 3GB+32GB @ Rs.6999 Only. Phone Is Packed With 5 Inch HD Display, 13MP Rear Camera | 5MP Front Camera, 3000 MAh Li-polymer Battery, Qualcomm Snapdragon 425 Processor And More. First Sale Will Be On 7th December 12.PM.
Redmi 5A Will Be Available in 2 Variants:
Something New From Xiaomi here is The Cheapest Model With 2GB RAM is Available For Only First 5 Million Buyers In India. Both Devices Will Have Colour Varients Of GOLD & GREY.
Price Of The Xiaomi Redmi 5A:
This Will Be The Cheapest Of All Launched Xiaomi Device in India.
- Redmi 5A – 2GB RAM + 16 GB Storage – Priced Rs.4999
- Redmi 5A – 3 GB RAM + 32 GB Storage – Priced Rs.6999
Specifications Of Redmi 5A:
Though This Phone Has Lower Price Point But Redmi 5A Has A Decent 5 Inch HD Display. Xiaomi Called it "Fully Laminated Display". mi is Also Providing The Popular Reading Mode In This Phone Which We Are Seeing in OnePlus & Flagship Devices. Pixel density Will Be 296ppi In This 5-inch HD (720×1280 pixels) display.
Battery :
Xiaomi Advertised 8 Days Stand By Time in Phone in This 3000 mAH Powered Battery. Surely Some Marketing Gimmick. But With The Optimisations Of Newly Launched MIUI 9, Battery Will Surely Stays Up to Half Day in Higher Huge & 1 Day in Normal Use.
Also Read-mCent Browser-Earn Mobile Recharges By Just Surfing Internet
Xiaomi Redmi 5A Will Features Custom Skin Of MIUI 9 On Top Of Android 7.1.2 Nouget. Also Phone Will Features A Snapdragon 425 SoC, clocked at 1.4GHz.
With 2GB/3GB RAM You Will Surely Runs Most Of Games From Playstore But In High-End Games With Higher Frame-Rate, You Will Notice Some Lags & Frame-Drops.
Dual Camera? No.. LoL … But Xiaomi is Providing The Decent 13-megapixel rear camera with f/2.2 aperture & 5-megapixel front camera with f/2.0 aperture lens. It supports 1080p and 720p video recording.
Camera Will Also Features Some Traditional Xiaomi Specs-
- Burst mode
- panorama mode
- HDR mode
Camera/Pictures Quality Will Be Same as Redmi 4A & Redmi 4 Smartphones. So, Don't Expect Something Innovative Or New In Camera Pictures.
Also Read-Xiaomi Redmi Y1-Xiaomi Selfie Budget Smartphone Launched
Xiaomi Has Launched The MIUI 9 And Has Many Noticeable Features Over MIUI 8.
- Smart assistant
- Split screen multitasking
- Smart app launcher
- Notification management
- Image search
- Quick reply
- Home screen enhancements
- Lock screen enhancements
Also Read-MIUI 9 Update-MIUI 9 Eligible Device List & Features You Must Know
And Many More. Best Thing About Xiaomi is They Updates Their Old Devices Regularly With At least MIUI Versions. Redmi 1S The First Xiaomi Device In India Still Getting The MIUI Updates.
- Network Type – 4G, 4G VOLTE, 2G, 3G
- Audio Jack – 3.5 mm
- Expandable Storage – 128 GB
- Bluetooth Version – 4.1
- Sensors – Ambient Light Sensor, Proximity Sensor, E-compass, Accelerometer, Gyroscope.
Flash Sale Date Of Xiaomi Redmi 5A:
Redmi 5A Will Be Having First Ever Flash Sale on 7th December 12 Noon On Flipkart & Mi India Website. We Will Soon Provides The Flash Sale Script Trick To Buy The Redmi 5A Successfully On Flipkart.


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South Korea's World Cup hopes are still alive despite defeat to Mexico on Saturday but their coach Shin Tae-yong says there are problems with the country's domestic game that cannot be ignored.
Korea were beaten 2-1 by Mexico after goals from Carlos Vela and Javier Hernandez put the result beyond doubt in Rostov before Son Heung-min's stunning late strike.
Son was in tears after the match but his consolation goal could yet prove significant in Group F.
Germany's last-gasp win over Sweden later on Saturday means South Korea can still qualify if they overcome the world champions next week and the Swedes also lose to Mexico.
But that would mark an incredible turn-around given Tae-yong's side are yet to register a point from their opening two games in Russia.
"We have systemic problems," Tae-yong said. "We must think how we can improve our domestic league and work with young players. We lack experience. That doesn?t come overnight."
Son, the team's star player, was left with too much to do up front, often isolated, and without sufficient support to take on the Mexican defence.
But Korea had chances and the momentum of the game turned on another penalty, awarded against Jang Hyun-soo for a blatant handball and converted by Vela. It was the 14th spot-kick of the tournament.
"Our players, I think, played a game that they will not regret," Tae-yong added.
"All of the players became one and until the last minute they really did their utmost. I really am very grateful that they did their best until the very last minute."


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On Tuesday 6th June 2017, an Educational Session took place during the 2017 American Society of Clinical Oncology (ASCO) Annual Meeting discussing emerging treatment options for Acute Myeloid Leukemia (AML) subsets.
The first talk during this enthralling session was given by the chair Richard M. Stone, M.D., from the Dana-Farber Cancer Institute, USA. He discussed the biology of Fms-Like Tyrosine Kinase 3 (FLT3) mutations in AML and gave an overview of early and ongoing trials using novel therapeutic agents targeting FLT3 mutations in AML patients.1
Mutations in the FLT3 gene represent one of the most commonly encountered, and clinically challenging, classes of AML mutations and it is expressed in approximately 30% of patients. There are two types of FLT3 mutations, Internal Tandem Duplication (ITD) in or near the juxtamembrane domain of the receptor and point mutations resulting in single amino acid substitutions occurring within the activation loop of the Tyrosine Kinase Domain (TKD).2 Patients with FLT3-ITD mutations present with a very large disease burden and have a worse prognosis than patients with wild-type FLT3 mutations and thus a key focus for therapy development.
Early studies with single-agent FLT3 inhibitors including midostaurin, lestaurtinib, and tandutinib in patients with advanced FLT3 mutated AML revealed that these agents lacked efficacy possibly due to AML biology. Additionally, these first generation FLT3 inhibitors were protein bound and lacked potency and specificity.
As a result, there has been a vast clinical development of novel therapies for FLT3 mutated AML. Emerging therapy for FLT3 mutated AML in clinical development involves two major streams, including the use of highly specific and potent FLT3 inhibitors such as quizartinib and gliteritinb in advanced AML and the use of first-generation FLT3 inhibitors in combination with chemotherapy in newly diagnosed FLT3-positive AML.
2nd generation FLT3 inhibitors in AML
Quizartinib, which specifically inhibits FLT3-ITD, is currently being evaluated in comparison with salvage chemotherapy in the phase III QuANTUM-R study (NCT02039726) in Relapsed or Refractory (R/R) AML patients, with the primary outcome being Overall Survival (OS). Previously reported results from a phase II study with quizartinib were discussed during the talk. In this study, the safety and efficacy of quizartinib monotherapy was evaluated in a cohort of 134 R/R AML patients (median age = 70 years). Patients were either FLT3-ITD positive (n = 90) or FLT3-ITD negative (n = 42). The key results of the study were: 3
- Composite Complete Remission (CRc) in FLT3-ITD+ and FLT3-ITD- patients; 53% vs 36%
- Median CRc duration in FLT3-ITD+ and FLT3-ITD- patients; 10.4 vs 9.3 weeks
Conversely, the phase I/II Chrysalis study (NCT02014558) of gilteritinib, a potent, oral FLT3/AXL inhibitor, in R/R AML patients was discussed. In this study, the safety and efficacy of gilteritinib monotherapy was evaluated in R/R AML patients. The key results of this study were:4
- Overall Response Rate (ORR) in FLT3 mutated AML patients and wild-type FLT3 AML patients; 49% vs 12%
The AML Global Portal interviewed Professor Jessica Altman, Northwestern University, on the molecular response to gilteritinib. She highlighted that the median OS in patients that had achieved a molecular response to gilteritinib was significantly longer than patients that did not achieve a molecular response.
Gilteritinib is currently being evaluated in comparison with salvage chemotherapy in a phase III study (NCT02421939) in R/R AML patients, with the primary outcome of the study being OS.
Richard M Stone highlighted that, although quizartinib and gilteritinib have more specificity for FLT3-ITD, there are still very few true CRs and thus suggested that given the rarity of CR, it might be better to combine FLT3 inhibitors with chemotherapy.
FLT3 inhibitors plus chemotherapy
Multiple studies with sorafenib, a multi-targeted kinase inhibitor, in combination with chemotherapy were then discussed. One of the studies included a phase II trial, by The Alliance for Clinical Trials in Oncology, evaluated sorafenib in combination with 7+3 induction chemotherapy and modified high-dose cytarabine-based post-remission therapy in newly diagnosed FLT3 mutated AML patients over the age of 60. The results of this study showed that addition of sorafenib to chemotherapy for FLT3-ITD AML improves the survival of older adults, more than doubling the 1-year OS compared to historical controls (62% vs 30%, P < 0.0001).5
Then the phase II randomized SORAML trial (NCT00893373) was discussed. In this study, 267 AML patients were randomly assigned to receive standard induction and post-remission chemotherapy with or without sorafenib. The key results of the study were:6
- Median Event Free Survival (EFS) in patients administered sorafenib (n = 134) and placebo (n = 133); 21 vs 9 months
- Median Relapse Free Survival (RFS) in patients administered sorafenib and placebo; not reached vs 23 months
- 3-year OS in patients administered sorafenib and placebo; 63% vs 56%, P = 0.382
The spotlight was then turned to another FLT3 inhibitor, lestaurtinib, and Richard M Stone discussed the analysis of two trials: AML15 (ISRCTN17161961) and AML17 (ISRCTN55675535) performed by Knapper et al. In these studies, lestaurtinib was added to front-line chemotherapy in patients with previously untreated AML in order to investigate its effect on clinical outcome of patients. The primary endpoints of these studies were OS and RFS. It was shown that lestaurtinib in combination with first-line chemotherapy in previously untreated AML patients did not have an overall clinical benefit; however, it was a feasible therapeutic option. Additionally, patients with sustained FLT3 inhibitory activity and patients who received azole therapy and gemtuzumab ozogamicin had an improved OS and lower rates of relapse.7
Studies with the recently U.S Food and Drug Administration (FDA) approved FLT3 inhibitor midostaurin was discussed next. In particular, the phase III RATIFY trial (NCT00651261), which is a randomized trial in 717 newly diagnosed FLT3+ AML patients. In this study, patients were randomly assigned to receive either placebo or midostaurin 50mg orally twice daily on days 8–21 of each cycle of induction and consolidation chemotherapy followed by continuous daily midostaurin for up to 12 cycles. The key results of the study were:
- OS in patients receiving midostaurin and placebo; 74.4 vs 25.6 months, HR = 0.77, P = 0.0074
Additionally, when patients were censored for transplantation analysis, a benefit for midostaurin was observed, especially in patients who underwent transplant in First Complete Remission (CR1).8
Richard M Stone concluded his talk by highlighting other upfront FLT3 inhibitor clinical trials in AML patients including crenolanib in combination with 3+7 chemotherapy which has shown 88% CR in 32 evaluable AML patients.


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St. Aloysius' College Educational Community Presents SACFEST 2011
The 7th edition of SAC Fest will kick off with the official inauguration of the Inner Ground on Friday 27th at 4pm. Work has been going on for the past 9 months and now Form 1 and Form 2 students may enjoy the luxury of a re-surfaced inner ground and its excellent facilities!
As in previous years we have a varied programme to keep you entertained throughout the weekend. Attractions include:
We also welcome with us ex-alumni - especially for the opening match on Friday at 4.45pm between ex-Aloysians and Sixth Formers. Whilst hoping that you enjoy yourselves, we would like to greet you wholeheartedly on College premises to help you revive the memories of many years spent with us.
This past month has been especially hectic. We started off with committee meetings and meetings for parent helpers. Eventually students involved themselves - stage crew members from both the sixth form and the secondary school have worked really hard till the early hours of the morning to set up the stage and all that goes on with it, whereas others have been busy rehearsing for the evening variety shows. All this has led to a great sense of friendship and unity amongst all those involved.
May we take this opportunity to thank all those involved in the preparations. The funds collected from SAC Fest will go towards the refurbishment of the theatre. Works started two years ago and will hopefully be completed by next year. This would certainly not be possible without the contribution and involvement of so many generous people. The list is too long to include in this page so if you have contributed in any way, please receive these heartfelt thanks from both of us, on behalf of the College.
Fr. Patrick Magro sj Ms Vanessa Portanier MifsudRector SAC Fest Co-Ordinator
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My Grandparents were very proud of Dad's travels with the Merchant Navy. On the wall of their home was a world map, with pins to show all the different places he'd visited. I used to spend hours looking at those pins and wondering.
Since 2010 I've been using Foursquare and its later stablemate, Swarm. These two apps allow you to check in to places you visit, find new places, read and write reviews. They're a bit like a very detailed, user-led version of TripAdvisor. You'll find lots of your local high street businesses have been added by customers, as well as the tops of mountains, or beaches.
Swarm is gamified to encourage people to keep checking in and become the Mayor of different locations. That's always felt pretty worthless to me. Although for a while Whetherspoons were offering discounts to Mayors of their pubs.
Foursquare is incredibly useful and with independent reviews, ideal for finding places to eat and visit in strange cities. In 2012 we spent a whole weekend navigating the best tapas bars of Barcelona using only Foursquare. Foursquare didn't let us down.
I leave reviews (or tips as they're known), in the hope they'll prove useful to others and maybe help the business who owns the location. Users receive some interesting data back on how many times their tips have been viewed and liked.
Mapping your travels with Foursquare and Fusion Tables
Until recently I didn't have a way to look back at check-ins. My work and a honeymoon has meant some interesting travel in the past few years. I was fairly certain that a global map, like the one my Grandparents had, would tell an interesting story.
I stumbled across this blog, last week, describing how to export Foursquare data and present it in a Fusion table and Google map. This is dead simple and a great way to get you, family and friends thinking about where you've been or the areas of a country that you frequent the most (you can create heat maps, instead of pins).
I think it's also a nice example of how free data behind a fairly utilitarian social media app can be easily extracted and plotted to a map, thanks to fantastic tools like Fusion Tables.
Here are my travels from the past couple of years: