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How do I apply for the NYSF Year 12 Program?
Please read all the information below before you start the application process. Applications are open from early March to June 14 each year.
There are five steps to applying for the NYSF Year 12 Program:
1. Start your application for the NYSF Year 12 Program
Follow the link below to start your application. First, you'll be prompted to check your eligibility. If you meet the eligibility criteria, you will start by entering your basic details. When you hit next, you will receive an email confirming that you're on your way! The email will include a link that you can use to return to your application, which you'll need if you're not able to complete it in the one sitting.
2. Complete all the application questions
There are several questions in the application, including some that will require longer answers that you might like to draft first. These include:
Please Tell Us About Yourself - your hobbies, interests and achievements and information on any extracurricular activities (up to 3000 characters)
Motivation - Why do you want to attend the NYSF Year 12 Program (up to 3000 characters)
Role of STEM - Why do you think STEM (Science, Technology, Engineering and Maths) is important? What role do you think STEM can play in helping us address current and future challenges? (up to 3000 characters)
Career Goals - What career do you currently intend to pursue? How do you plan to achieve this career goal? If you're not sure at this point that's fine, just write what you are currently most interested in. (up to 3000 characters)
Post Year 12 Intentions - What are your intentions for after Year 12? i.e. do you plan to attend university straight away, take a gap year and travel, look for employment, or something else? (up to 3000 characters)
University Study - If you are thinking about studying at university after finishing Year 12, please give details about the degree and institution you're most interested in at the moment. (up to 3000 characters)
3. Determine the fee option you will take
In 2019, certain Rotary Districts introduced a new option that applicants can choose with regards to payment of the program fee. For applicants who would not require funding assistance to cover their program fee, should they be selected to attend the program, the step of obtaining endorsement from a Rotary Club to proceed with your application will no longer be required. If choosing this self-funded option, applicants can progress directly to payment of the application fee and submission of your application without needing to contact a Rotary Club. You will only see this self-funded option in your application, if you are in a Rotary District currently offering this option.
Option to seek Rotary Endorsement. This option involves finding a local Rotary Club to endorse your application. Once you've started your application, you will have access to download the endorsement form once you reach this step. Alternatively, you can download a copy here.
Applicants will need to contact local clubs in your area, to find a club to endorse your application and complete the form. Each Rotary Club may have different endorsement procedures. They may require a formal interview, or further details from you, such as copies of your school reports, teacher references, and/or a printed or electronic copy of the information provided in your NYSF Application. You can read about the role of Rotary Clubs here and check for your local club using the Rotary Club Finder tool.
This option is best for those who may experience difficulties paying the $3,250 program fee. Please note, however, while Rotary Clubs can often offer support in this regard, Rotary Clubs have no obligation to offer any funding towards the fee for you to attend the program. Endorsement does not necessarily mean you will receive any financial support from your Rotary Club. You will need to negotiate this as part of your discussion and ensure that you and your family understand what, if any, level of financial support is available from your Rotary Club. At the least, your club may be able to offer some assistance with fund-raising efforts in your community.
Once you have secured the endorsement of a Rotary Club, ask a member of the club to complete the Rotary Endorsement Form. Once complete, upload your form to your application. You'll then be ready to review and submit your application. If you are having any difficulties at all with this process, please contact the NYSF Office via our contact form.
Option to be self-funded. This option is for those who are able to self-fund, and don't require any assistance to cover the full fee to attend the program, should they be successful. In this instance, once the application questions are completed you will be able to move directly to paying the $65 application fee and submitting your application.
4. Pay your application fee
Once you have finalised how you will progress your application, you can then progress to the 'Payment' tab where you will be prompted to pay the $65 application fee. Once paid, your application will be complete and you will receive a confirmation email. Please note that the application fee is non-refundable, even for applicants not selected to attend the NYSF Year 12 Program.
Applications for the NYSF Year 12 Program 2021 close on 14 June, midnight AEST. Please ensure you have completed the above steps before this date as we are unable to accept late applications.
5. Participate in District Selections
Once your application is submitted, the next step will be to attend the NYSF District Selection for your local Rotary District. At selections, the NYSF District Chair will run a panel interview process or similar that will consider all of the district's applicants on their merit. Please note that at this stage of the process, whether you are self-funded or Rotary endorsed, this will not be part of the consideration and all applicants will be assessed on the same criteria.
Your local NYSF District Chair will advise you on the process involved and the dates of your local selections. You will need to keep checking your emails to see whether further information is required from you before proceeding to District Selections.
If you have any questions about this process please contact the NYSF office or call 02 61252777.
More information about the NYSF Year 12 program can be found here.


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OBJECTIVE: Treatment effects to binary endpoints using time-to-event data in randomised controlled trials are typically summarised by reporting HRs derived with Cox proportional hazard models. Alternative and complementary methods include summarising the between-treatment differences on the metric time scale, quantifying the effect as delay of the event (DoE). The aim of this study was to reassess data from the PLATO study expressing the effects as the time by which the main outcomes are delayed or hastened due to treatment.
METHODS: PLATO was a randomised controlled double-blind multicentre study (n=18,624), conducted between 2006 and 2008, which demonstrated superiority of the antiplatelet treatment ticagrelor over clopidogrel in reducing risk of several cardiovascular events. In the present study, four of the main PLATO outcomes were reassessed by calculating the time by which an event may be delayed due to the treatment.
RESULTS: The effects of ticagrelor, as compared with clopidogrel, consisted of a substantial delay of the evaluated outcomes, ranging from 83 to 98 days over 400-day follow-up. The Delay of Events Curves showed that the effects progressively increased over time, and the significant findings were concordant with those presented in the original PLATO study.
CONCLUSIONS: This study confirmed evidence of a beneficial effect of ticagrelor over clopidogrel, and provided the magnitude of such effects in terms of delayed event time. Investigating time-to-event data with a percentile approach allows presenting treatment effects from randomised controlled studies as absolute measures of the time by which an event may be delayed due to the treatment.
TRIAL REGISTRATION NUMBER: PLATO (www.clinicaltrials.gov; NCT00391872); Results.
IMPORTANCE Vitamin K antagonist (eg, warfarin) use is nowadays challenged by the non-vitamin K antagonist oral anticoagulants (NOACs) for stroke prevention in atrial fibrillation (AF). NOAC studies were based on comparisons with warfarin arms with times in therapeutic range (TTRs) of 55.2% to 64.9%, making the results less credible in health care systems with higher TTRs. OBJECTIVES To evaluate the efficacy and safety of well-managed warfarin therapy in patients with nonvalvular AF, the risk of complications, especially intracranial bleeding, in patients with concomitant use of aspirin, and the impact of international normalized ratio (INR) control. DESIGN, SETTING, AND PARTICIPANTS A retrospective, multicenter cohort study based on Swedish registries, especially AuriculA, a quality register for AF and oral anticoagulation, was conducted. The register contains nationwide data, including that from specialized anticoagulation clinics and primary health care centers. A total of 40 449 patients starting warfarin therapy owing to nonvalvular AF during the study period were monitored until treatment cessation, death, or the end of the study. The study was conducted from January 1, 2006, to December 31, 2011, and data were analyzed between February 1 and November 15, 2015. Associating complications with risk factors and individual INR control, we evaluated the efficacy and safety of warfarin treatment in patients with concomitant aspirin therapy and those with no additional antiplatelet medications. EXPOSURES Use of warfarin with and without concomitant therapy with aspirin. MAIN OUTCOMES AND MEASURES Annual incidence of complications in association with individual TTR (iTTR), INR variability, and aspirin use and identification of factors indicating the probability of intracranial bleeding. RESULTS Of the 40 449 patients included in the study, 16 201 (40.0%) were women; mean (SD) age of the cohort was 72.5 (10.1) years, and the mean CHA(2)DS(2)-VASc (cardiac failure or dysfunction, hypertension, age >= 75 years [doubled], diabetes mellitus, stroke [doubled]-vascular disease, age 65-74 years, and sex category [female]) score was 3.3 at baseline. The annual incidence, reported as percentage (95% CI) of all-cause mortality was 2.19% (2.07-2.31) and, for intracranial bleeding, 0.44%(0.39-0.49). Patients receiving concomitant aspirin had annual rates of any major bleeding of 3.07%(2.70-3.44) and thromboembolism of 4.90% (4.43-5.37), and those with renal failure were at higher risk of intracranial bleeding (hazard ratio, 2.25; 95% CI, 1.32-3.82). Annual rates of any major bleeding and any thromboembolism in iTTR less than 70% were 3.81% (3.51-4.11) and 4.41% (4.09-4.73), respectively, and, in high INR variability, were 3.04%(2.85-3.24) and 3.48% (3.27-3.69), respectively. For patients with iTTR 70% or greater, the level of INR variability did not alter event rates. CONCLUSIONS AND RELEVANCE Well-managed warfarin therapy is associated with a low risk of complications and is still a valid alternative for prophylaxis of AF-associated stroke. Therapy should be closely monitored for patients with renal failure, concomitant aspirin use, and poor INR control.
Background: Warfarin treatment in Sweden holds a high standard with time in therapeutic range (TTR) over 75%. Internationally, specialized anticoagulation clinics (ACC) have shown higher TTR compared to primary health care centres (PHCC). Objectives: To compare warfarin treatment quality in Sweden for ACC versus PHCC, thereby clarifying whether centralization is for the better. Patients/methods: In total 77.058 patients corresponding to 217.058 treatment years with warfarin in the Swedish national quality register AuriculA from 1. Jan 2006 to 31. Dec 2011. Information regarding TTR was calculated from AuriculA, while patient characteristics and complications were retrieved from the Swedish National Patient Register. Results: Of the 100.554 treatment periods examined, 78.7% were monitored at ACC. Mean TTR for INR 2-3 for all patients irrespective of intended target range was 76.5% with an annual risk of bleeding or thrombotic events of 2.24% and 2.66%, respectively. TTR was significantly higher in PHCC compared to ACC (79.6% vs. 75.7%, p < 0.001), with no significant difference in overall risk of complications. Treatment periods for atrial fibrillation, except intended direct current conversion, showed similar results between ACC and PHCC without significant difference in annual risk of bleeding (2.50% vs. 2.51%) or thrombosis (3.09% vs. 3.16%). After propensity score matching there was still no significant difference in complication risk found. Conclusions: Warfarin treatment quality is consistently high in both ACC and PHCC when monitored through AuriculA in Sweden, both measured as TTR and as risk of complications. In this setting, centralized warfarin monitoring is not likely to improve the results.
Introduction: Warfarin treatment discontinuation is significant among patients with atrial fibrillation (AF). For AF patients with stroke a warfarin persistence rate of 0.45 after 2 years has previously been reported. No consistent predictors for discontinuation have been established. Aims: Evaluation of warfarin persistence and variables associated with discontinuation, in a large Swedish cohort with unselected stroke/TIA patients with AF treated with warfarin. Materials and methods: 4 583 patients with stroke/TIA and AF in the Swedish National Patient Register (NPR), from 1. Jan 2006 to 31. Dec 2011, were matched with the Swedish national quality register AuriculA. They were followed until treatment cessation, death or end of study. Baseline characteristics and CHA(2)DS(2)VASc score were retrieved from NPR. Treatment-time was retrieved from AuriculA. Results: Overall proportion of warfarin persistence was 0.78 (95% confidence interval (CI) 0.76 to 0.80) after one year, 0.69 (95% CI 0.67 to 0.71) after 2 years and 0.47 (95% CI 0.43 to 0.51) after 5 years. Variables clearly associated with higher discontinuation were dementia (hazard ratio (HR) 2.22, CI 1.51-3.27) and alcohol abuse (HR 1.66, CI 1.19-2.33). Chronic obstructive pulmonary disease (COPD), cancer and chronic heart failure (CHF) were each associated with over 20% increased risk of treatment discontinuation. Higher CHA(2)DS(2)VASc score and start-age lead to lower persistence (p < 0.001). Conclusions: Persistence to warfarin in unselected stroke/TIA patients with AF is in Sweden greater than previously reported. Lower persistence is found among patients with high treatment start-age, incidence of dementia, alcohol abuse, cancer, CHF, COPD and/or high CHA(2)DS(2)VASc score.
Objectives We aimed to analyse outcomes of ticagrelor and clopidogrel stratified by estimated glomerular filtration rate (eGFR) in a large unselected cohort of patients with acute myocardial infarction (MI). Methods We used follow-up data in MI survivors discharged on ticagrelor or clopidogrel enrolled in the Swedish Web-System for Enhancement and Development of Evidence-Based Care in Heart Disease Evaluated According to Recommended Therapies registry. The association between ticagrelor versus clopidogrel and the primary composite outcome of death, MI or stroke and the secondary outcome rehospitalisation with bleeding diagnosis at 1year, was studied using adjusted Cox proportional hazards models, stratifying after eGFR levels. Results In total, 45 206 patients with MI discharged on clopidogrel (n=33472) or ticagrelor (n=11734) were included. The unadjusted 1-year event rate for the composite endpoint of death, MI or stroke was 7.0%, 18.0% and 48.0% for ticagrelor treatment and 11.0%, 33.0% and 64.0% for clopidogrel treatment in patients with eGFR(>60) (n=33668), eGFR(30-60) (n=9803) and eGFR(<30) (n=1735), respectively. After adjustment, ticagrelor as compared with clopidogrel was associated with a lower 1-year risk of the composite outcome (eGFR(>60): HR 0.87, 95%CI 0.76 to 99, eGFR(30-60): 0.82 (0.70 to 0.97), eGFR(<30): 0.95 (0.69 to 1.29), P for interaction=0.55) and a higher risk of bleeding (eGFR(>60): HR 1.10, 95%CI 0.90 to 1.35, eGFR(30-60): 1.13 (0.84 to 1.51), eGFR(<30): 1.79 (1.00 to 3.21), P for interaction=0.30) across the eGFR strata. Conclusions Treatment with ticagrelor as compared with clopidogrel in patients with MI was associated with lower risk for the composite of death, MI or stroke and a higher bleeding risk across all strata of eGFR. Of caution, bleeding events were more abundant in patients with eGFR(<30).
Introduction Warfarin treatment with a high time in therapeutic range (TTR) is correlated to fewer complications. The TTR in Sweden is generally high but varies partly depending on local expertise and traditions. A dosing algorithm could minimize variations and increase treatment quality. Here we evaluate the performance of a computerized dosing algorithm. Materials and methods 53.779 warfarin treated patients from 125 centers using the Swedish national quality registry AuriculA. If certain criteria are met, the algorithm gives one of seven possible dose suggestions, which can be unchanged, decreased or increased weekly dose by 5, 10 or 15%. The outcome evaluated by the resulting INR value was compared between dose suggestions arising from the algorithm that were accepted and those that were manually changed. There were no randomization, and outcomes were retrospectively analyzed. Results Both the algorithm-based and the manually changed doses had worse outcome if only two instead of three previous INR values were available. The algorithm suggestions were superior to manual dosing regarding percent samples within the target range 2-3 (hit-rate) or deviation from INR 2.5 (mean error). Of the seven possible outcomes from the algorithm, six were significantly superior and one equal to the manually changed doses when three previous INR:s were present. Conclusions The algorithm-based dosing suggestions show better outcome in most cases. This can make dosing of warfarin easier and more efficient. There are however cases where manual dosing fares better. Here the algorithm will be improved to further enhance its dosing performance in the future.
Objectives To study the impact of time in therapeutic range (TTR) and international normalised ratio (INR) variability on the risk of thromboembolic events, major bleeding complications and death after mechanical heart valve (MHV) implantation. Additionally, the importance of different target INR levels was elucidated. Methods A retrospective, non-randomised multicentre cohort study including all patients with mechanical heart valve (MVH) prosthesis registered in the Swedish National Quality Registry Auricula from 2006 to 2011. Data were merged with the Swedish National Patient Registry, SWEDEHEART and Cause of Death Registry. Results In total 4687 ordination periods, corresponding to 18 022 patient-years on warfarin, were included. High INR variability (above mean >= 0.40) or lower TTR (<= 70%) was associated with a higher risk of bleeding (rate per 100 years 4.33 (95% CI 3.87 to 4.82) vs 2.08 (1.78 to 2.41); HR 2.15 (1.75 to 2.61) and 5.13 (4.51 to 5.82) vs 2.30 (2.03 to 2.60); HR 2.43 (2.02 to 2.89)), respectively. High variability and low TTR combined was associated with an even higher risk of bleedings (rate per 100 years 4.12 (95% CI 3.68 to 4.51) vs 2.02 (1.71 to 2.30); HR 2.16 (1.71 to 2.58) and 4.99 (4.38 to 5.52) vs 2.36 (2.06 to 2.60); HR 2.38 (2.05 to 2.85)) compared with the best group. Higher treatment intensity (mean INR 2.8-3.2 vs 2.2-2.7) was associated with higher rate of bleedings (2.92 (2.39 to 3.47) vs 2.48 (2.21 to 2.77); HR 1.29 (1.06 to 1.58)), death (3.36 (2.79 to 4.02) vs 1.89 (1.64 to 2.17), HR 1.65 (1.31 to 2.06)) and complications in total (6.61 (5.74 to 7.46) vs 5.65 (5.20 to 6.06); HR 1.24 (1.06 to 1.41)) after adjustment for MHV position, age and comorbidity. Conclusions A high warfarin treatment quality improves outcome after MHV implantation, both measured with TTR and INR variability. No benefit was found with higher treatment intensity (mean INR 2.8-3.2 vs 2.2-2.7).
Introduction: Direct oral anticoagulants (DOACs) have been proven non-inferior or superior to warfarin in preventing stroke and systemic embolism, with a lower risk of major hemorrhage, in patients with non-valvular atrial fibrillation (NVAF). We sought to investigate whether effectiveness and safety differs among apixaban, rivaroxaban and dabigatran.
Materials and methods: Patients with newly initiated DOAC treatment were identified from the Swedish anticoagulation quality registry, ranging from January 1, 2013 to December 31, 2015. Patients were assigned to apixaban, dabigatran or rivaroxaban cohorts based on initiated DOAC and dose (standard or reduced). Baseline characteristics and endpoints were retrieved from validated Swedish quality registers and the National Patient Registry. Cohorts were matched using full optimal matching and directly compared.
Results: A total of 25,843 NVAF patients were included. Patients treated with standard dose apixaban or dabigatran had lower risk of major bleeding than patients treated with rivaroxaban, HR 0.69 (95% CI 0.54-0.88) and HR 0.64 (95% CI 0.48-0.87). Regarding reduced dose, patients treated with apixaban had lower risk of major bleeding than those treated with dabigatran or rivaroxaban, HR 0.62 (95% CI 0.44-0.88) and HR 0.45 (95% CI 0.33-0.61). In reduced dose, patients treated with dabigatran had the lowest all-cause mortality. No differences in effectiveness were found.
Conclusions: In this large real-world NVAF cohort, direct comparisons show a favorable bleeding risk profile for dabigatran and apixaban in standard dose, and for apixaban in reduced dose. No differences in effectiveness were found. This study confirms previous indirect DOAC comparisons. Further studies are needed.
The aim of this study was to compare the prognoses of patients with ST-segment elevation myocardial infarction (STEMI) and those with non-ST-segment elevation myocardial infarction (NSTEMI) without obstructive coronary artery disease (CAD) and the risk associated with gender for future cardiovascular events. The study population was selected from 95,849 patients who underwent coronary angiography for myocardial infarction from 2005 to 2010 and registered in the Swedish Coronary Angiography and Angioplasty Registry (SCAAR). Outcome analyses, including all-cause death, myocardial infarction, congestive heart failure, stroke, and revascularization, were performed in 2,268 patients with STEMI and 10,904 with NSTEMI without obstructive CAD (<50% stenosis). Hazard ratios and 95% confidence intervals comparing women with men were calculated for events, adjusting for cardiovascular risk factors and age. Nonobstructive CAD was found in 7% of patients with STEMI (6% men, 10% women) and in 17% of those with NSTEMI (11% men, 28% women). During a median follow-up of 2.6 years, 8% of patients with STEMI and 5% of those with NSTEMI died. Gender-associated differences in risk were observed in patients with NSTEMI, with adjusted hazard ratios lower in women than men for mortality (hazard ratio 0.90, 95% confidence interval 0.50 to 0.73) and congestive heart failure (hazard ratio 0.61, 95% confidence interval 0.52 to 0.72). In the 2 groups, women underwent less revascularization. In conclusion, nonobstructive CAD was more common in patients with NSTEMI than those with STEMI, as well as in women compared with men. Long-term mortality in patients with nonobstructive CAD was higher after STEMI than NSTEMI. The gender differences in outcomes suggest gender differences in the underlying pathogenesis of myocardial infarction without obstructive CAD.
BACKGROUND: Thrombus aspiration during percutaneous coronary intervention (PCI) for the treatment of ST-segment-elevation myocardial infarction (STEMI) has been widely used; however, recent trials have questioned its value and safety. In this meta-analysis, we, the trial investigators, aimed to pool the individual patient data from these trials to determine the benefits and risks of thrombus aspiration during PCI in patients with ST-segment-elevation myocardial infarction. METHODS: Included were large (n >= 1000), randomized, controlled trials comparing manual thrombectomy and PCI alone in patients with ST-segment-elevation myocardial infarction. Individual patient data were provided by the leadership of each trial. The prespecified primary efficacy outcome was cardiovascular mortality within 30 days, and the primary safety outcome was stroke or transient ischemic attack within 30 days. RESULTS: The 3 eligible randomized trials (TAPAS [Thrombus Aspiration During Percutaneous Coronary Intervention in Acute Myocardial Infarction], TASTE [Thrombus Aspiration in ST-Elevation Myocardial Infarction in Scandinavia], and TOTAL [Trial of Routine Aspiration Thrombectomy With PCI Versus PCI Alone in Patients With STEMI]) enrolled 19 047 patients, of whom 18 306 underwent PCI and were included in the primary analysis. Cardiovascular death at 30 days occurred in 221 of 9155 patients (2.4%) randomized to thrombus aspiration and 262 of 9151 (2.9%) randomized to PCI alone (hazard ratio, 0.84; 95% confidence interval, 0.70-1.01; P=0.06). Stroke or transient ischemic attack occurred in 66 (0.8%) randomized to thrombus aspiration and 46 (0.5%) randomized to PCI alone (odds ratio, 1.43; 95% confidence interval, 0.98-2.10; P=0.06). There were no significant differences in recurrent myocardial infarction, stent thrombosis, heart failure, or target vessel revascularization. In the subgroup with high thrombus burden (TIMI [Thrombolysis in Myocardial Infarction] thrombus grade >= 3), thrombus aspiration was associated with fewer cardiovascular deaths (170 [2.5%] versus 205 [3.1%]; hazard ratio, 0.80; 95% confidence interval, 0.65-0.98; P=0.03) and with more strokes or transient ischemic attacks (55 [0.9%] versus 34 [0.5%]; odds ratio, 1.56; 95% confidence interval, 1.02-2.42, P=0.04). However, the interaction P values were 0.32 and 0.34, respectively. CONCLUSIONS: Routine thrombus aspiration during PCI for ST-segment-elevation myocardial infarction did not improve clinical outcomes. In the high thrombus burden group, the trends toward reduced cardiovascular death and increased stroke or transient ischemic attack provide a rationale for future trials of improved thrombus aspiration technologies in this high-risk subgroup.
Although routine invasive management is recommended in NSTEMI patients, the optimal timing of the procedure is not defined. The aim of this study was to assess outcomes in relation to timing of PCI in NSTEMI patients.
Methods and results
This was an observational, prospective, multicentre cohort study from the SWEDEHEART registry including all Swedish PCI centres. We included 40 494 consecutive PCI-treated patients who were admitted to any coronary care unit from 2006 to 2013. The primary outcome was all-cause death, and secondary outcomes were recurrent myocardial infarction (MI), stent thrombosis, and severe in-hospital bleeding. Outcomes were assessed within 1 year from admission in relation to pre-specified cut-offs to define early PCI: within 1, 2, or 3 days. Patients who received delayed PCI, compared with those who did not, were older, and had a higher prevalence of comorbidities (hypertension, hyperlipidaemia, diabetes, and prior stroke) but showed similar angiographic findings. Cox mixed-effects models showed a lower risk of all-cause death with early PCI across all three cut-offs: HR (95% CI) of 0.88 (0.80–0.98), 0.78 (0.71–0.86), and 0.75 (0.68–0.84), for the 1-, 2-, and 3-day cut-offs, respectively. Early PCI was associated with lower risk of recurrent MI for the 2- and 3-day cut-offs, but not for the 1-day cut-off. The reported rates of severe in-hospital bleeding were low, but tended to be higher in patients receiving delayed PCI.
In patients undergoing PCI for NSTEMI, early invasive treatment is associated with lower risk of ischaemic outcomes.
BACKGROUND: Routinely collected laboratory biomarkers could improve control of confounding from disease severity in non-interventional studies of general intensive care unit (ICU) patients. Their ability to predict both short- and long-term mortality was evaluated.
METHODS: The performance of age, sex, Charlson co-morbidity index, and baseline values of ten predefined blood biomarkers as predictors of 30-day and 1-year mortality was evaluated in 5505 general ICU stays.
RESULTS: Regression models based on age, sex, Charlson index, and biomarkers were somewhat less accurate in predicting 30-day mortality (c-index 0.83, Brier score 0.27) compared to the SAPS II score (c-index = 0.88, Brier score = 0.09) and in predicting 1-year mortality (c-index = 0.82, Brier score = 0.31) compared to the SAPS II score (c-index = 0.85, Brier score = 0.13). Cystatin C improved predictive ability slightly compared to creatinine, but age and Charlson comorbidity index were more important predictors. Using multiple imputation to replace missing biomarker values notably improved predictive ability of the models.
CONCLUSIONS: Automatically collected baseline variables are almost as predictive of both short- and long-term mortality in general ICU patients, as the SAPS II score. This can facilitate internal control of confounding in non-interventional studies of mortality using administrative data.
Aims Preliminary studies suggest that direct stenting (DS) during percutaneous coronary intervention (PCI) may reduce microvascular obstruction and improve clinical outcome. Thrombus aspiration may facilitate DS. We assessed the impact of DS on clinical outcome and myocardial reperfusion and its interaction with thrombus aspiration among ST-segment elevation myocardial infarction (STEMI) patients undergoing PCI. Methods and results Patient-level data from the three largest randomized trials on routine manual thrombus aspiration vs. PCI only were merged. A 1:1 propensity matched population was created to compare DS and conventional stenting. Synergy between DS and thrombus aspiration was assessed with interaction P-values in the final models. In the unmatched population (n= 17329), 32% underwent DS and 68% underwent conventional stenting. Direct stenting rates were higher in patients randomized to thrombus aspiration as compared with PCI only (41% vs. 22%; P < 0.001). Patients undergoing DS required less contrast (162 mL vs. 172 mL; P < 0.001) and had shorter fluoroscopy time (11.1 min vs. 13.3 min; P < 0.001). After propensity matching (n = 10944), no significant differences were seen between DS and conventional stenting with respect to 30-day cardiovascular death [1.7% vs. 1.9%; hazard ratio 0.88, 95% confidence interval (CI) 0.55-1.41; P=0.60; P-interaction = 0.96) and 30-day stroke or transient ischaemic attack (0.6% vs. 0.4%; odds ratio 1.02; 95% CI 0.14-7.54; P= 0.99; P-interaction = 0.81). One-year results were similar. No significant differences were seen in electrocardiographic and angiographic myocardial reperfusion measures. Conclusion Direct stenting rates were higher in patients randomized to thrombus aspiration. Clinical outcomes and myocardial reperfusion measures did not differ significantly between DS and conventional stenting and there was no interaction with thrombus aspiration.
We determine the asymptotic speed of the first-passage percolation process on some ladder-like graphs (or width-2 stretches) when the times associated with different edges are independent and exponentially distributed but not necessarily all with the same mean. The method uses a particular Markov chain associated with the first-passage percolation process and properties of its stationary distribution.
We prove a central limit theorem applicable to one dimensional stochastic approximation algorithms that converge to a point where the error terms of the algorithm do not vanish. We show how this applies to a certain class of these algorithms that in particular covers a generalized Pólya urn model, which is also discussed. In addition, we show how to scale these algorithms in some cases where we cannot determine the limiting distribution but expect it to be non-normal.
This PhD thesis consists of a summary and four papers which deal with stochastic approximation algorithms and first-passage percolation.
Paper I deals with the a.s. limiting properties of bounded stochastic approximation algorithms in relation to the equilibrium points of the drift function. Applications are given to some generalized Pólya urn processes.
Paper II continues the work of Paper I and investigates under what circumstances one gets asymptotic normality from a properly scaled algorithm. The algorithms are shown to converge in some other circumstances, although the limiting distribution is not identified.
Paper III deals with the asymptotic speed of first-passage percolation on a graph called the ladder when the times associated to the edges are independent, exponentially distributed with the same intensity.
Paper IV generalizes the work of Paper III in allowing more edges in the graph as well as not having all intensities equal.
We consider first-passage percolation on a ladder, i.e., the graph N x {0, 1}, where nodes at distance 1 are joined by an edge, and the times are exponentially i.i.d. with mean 1. We find an appropriate Markov chain to calculate an explicit expression for the time constant whose numerical value is approximate to 0.6827. This time constant is the long-term average inverse speed of the process. We also calculate the average residual time.
Aims Ticagrelor reduces ischaemic events and mortality in acute coronary syndrome (ACS) vs. clopidogrel. We wished to study clinical outcomes in a large real-world population post-ACS. Methods and results We performed a prospective cohort study in 45 073 ACS patients enrolled into SwedishWeb system for Enhancement and Development of Evidence-based care in Heart Disease Evaluated According to Recommended Therapies who were discharged on ticagrelor (N = 11 954) or clopidogrel (N = 33 119) between 1 January 2010 and 31 December 2013. The primary outcome was a composite of all-cause death, re-admission with myocardial infarction (MI) or stroke, secondary outcomes as the individual components of the primary outcome, and re-admission with bleeding. The risk of the primary outcome with ticagrelor vs. clopidogrel was 11.7 vs. 22.3% (adjusted hazard ratio (HR) 0.85 [95% confidence interval: 0.78-0.93]), risk of death 5.8 vs. 12.9% (adjusted HR 0.83 [0.75-0.92]), and risk of MI 6.1 vs. 10.8% (adjusted HR 0.89 [0.78-1.01]) at 24 months. Re-admission with bleeding with ticagrelor vs. clopidogrel occurred in 5.5 vs. 5.2% (adjusted HR 1.20 [1.04-1.40]). In a subset of patients undergoing percutaneous coronary intervention (PCI) on ticagrelor vs. clopidogrel the PCI-related in-hospital bleeding was 3.7 vs. 2.7% (adjusted odds ratio, OR, 1.57 [1.30-1.90]). Conclusion Ticagrelor vs. clopidogrel post-ACS was associated with a lower risk of death, MI, or stroke, as well as death alone. Risk of bleeding was higher with ticagrelor. These real-world outcomes are consistent with randomized trial results.
High quality of warfarin treatment is important to prevent recurrence of venous thromboembolism (VTE) without bleeding complications. The aim of this study was to examine the effect of individual time in therapeutic range (iTTR) and International Normalised Ratio (INR) variability on bleeding risk and mortality in a large cohort of well managed patients with warfarin due to VTE. A cohort of 16612 patients corresponding to 19502 treatment periods with warfarin due to VTE between January 1, 2006 and December 31, 2011 was retrieved from the Swedish national quality register AuriculA and matched with the Swedish National Patient Register for bleeding complications and background characteristics and the Cause of death register for occurrence and date of death. The rate of bleeding was 1.79 (confidence interval (CI) 95 % 1.66-1.93) per 100 treatment years among all patients. Those with poor warfarin treatment quality had a higher rate of clinically relevant bleeding, both when measured as iTTR below 70%, 2.91 (CI 95% 2.61-3.21) or as INR variability over the mean value 0.85, 2.61 (CI 95% 2.36-2.86). Among those with both high INR variability and low iTTR the risk of clinically relevant bleeding was clearly increased hazard ratio (HR) 3.47 (CI 95 % 2.89-4.17). A similar result was found for all-cause mortality with a HR of 3.67 (CI 95 % 3.02-4.47). Both a low iTTR and a high INR variability increase the risk of bleeding complications or mortality. When combining the two treatment quality indicators patients at particular high risk of bleeding or death can be identified.
Background: The mean time in target range for each centre, cTTR, has previously been shown to correlate to the rate of complications in poorly managed warfarin treatment. However less is known about the correlation when warfarin treatment is well managed. Objectives: The aim of this study was to examine the correlation between cTTR and the rate of complications in a real life setting with cTTR above 70%, with focus on patients with warfarin due to atrial fibrillation or secondary prevention of a VTE. Patients/methods: In total 66,605 patients with 89,293 treatment periods, corresponding to 179,624 treatment years, with warfarin treatment due to VTE or AF between January 1st 2006 and December 31th 2011, was retrieved from the national quality register AuriculA. The cohort was matched with the National Patient Register in Sweden for complications and background characteristics. Results: We found 172 centres and 68,797 treatment periods for AF and 166 centres and 20,496 treatment periods for VTE. Over 90% of the patients had a target range between INR 2-3. We found no correlation between increasing cTTR and reduction in the rate of complications for the AF patients. However, for VTE patients we saw a correlation between increasing cTTR and a reduced complication rate. Conclusions: Our results show that at very high cTTR levels, above 70%, further improvements in cTTR do not correlate to less treatment complications at least for patients with AF.
Anticoagulation treatment is effective in preventing both death and recurrence in patients with venous thromboembolism (VTE), but at the same time confers a substantial risk of bleeding complications. The aim of this study was to examine the rate of and predictors for bleeding complications in VTE patients on warfarin with high treatment quality. In total 13,859 patients on warfarin for VTE between January 1st 2006 and December 31th 2011 were retrieved from the national quality register Auricula. The cohort was matched with the Swedish National Patient Register for complications and background characteristics, the Cause of Death Register for date and cause of death and the Swedish Prescribed Drug Register for retrieved medication. The rate of major bleeding was 2.36 per 100 treatment years, increasing with age from 1.25 to 4.33 for those under 60 or over 80 years of age, respectively. Factors found to independently increase the risk of bleeding complications were increasing age HR 1.02, cardiac failure HR 1.39, Chronic pulmonary disease HR 1.41, alcohol abuse HR 3.33, anaemia HR 1.75, hypertension HR 1.29 and a history of major bleeding HR 1.69. Warfarin as treatment for VTE is safe with a low rate of bleeding complications at least for the younger patient. In an era of NOAK, warfarin has a comparable safety profile among VTE patients and is still a valid treatment option.
The safety and efficacy of warfarin in a large, unselected cohort of warfarin-treated patients with high quality of care is comparable to that reported for non-vitamin K antagonists. Warfarin is commonly used for stroke prevention in atrial fibrillation, as well as for treatment and prevention of venous thromboembolism. While reducing risk of thrombotic/embolic incidents, warfarin increases the risk of bleeding. The aim of this study was to elucidate risks of bleeding and thromboembolism for patients on warfarin treatment in a large, unselected cohort with rigorously controlled treatment. This was a retrospective, registry-based study, covering all patients treated with warfarin in the Swedish national anticoagulation register Auricula, which records both primary and specialised care. The study included 77,423 unselected patients with 100,952 treatment periods of warfarin, constituting 217,804 treatment years. Study period was January 1, 2006 to December 31, 2011. Atrial fibrillation was the most common indication (68%). The mean time in therapeutic range of the international normalised ratio (INR) 2.0-3.0 was 76.5%. The annual incidence of I severe bleeding was 2.24% and of thromboembolism 2.65%. The incidence of intracranial bleeding was 0.37% per treatment year in the whole population, and 0.38% among patients with atrial fibrillation. In conclusion, warfarin treatment where patients spend a high proportion of time in the therapeutic range is safe and effective, and will continue to be a valid treatment option in the era of newer oral anticoagulants.
Introduction: New oral anticoagulants are non-inferior compared with warfarin regarding stroke prevention in atrial fibrillation, with similar or decreased risk of bleeding. However, it is unclear whether high TTR warfarin is as effective and safe as NOACs. Our objective was to investigate efficacy and safety of apixaban, dabigatran or rivaroxaban compared with warfarin in clinical practice. Materials and methods: Nationwide retrospective cohort study based on Swedish quality registries. Atrial fibrillation patients initiated on apixaban, dabigatran, rivaroxaban or warfarin between 2013-01-01 and 2015-1231 were included. Main outcome measures were all-cause stroke and systemic embolism, all-cause stroke, ischemic stroke, hemorrhagic stroke; major bleeding, intracranial bleeding, gastrointestinal bleeding, other bleeding (fatal or requiring hospital care); all-cause mortality; myocardial infarction. Results: The study included 64,382 patients corresponding to 81,176 treatment years. Of these, 37,174 patients were instituted on warfarin, 6574 on dabigatran, 8323 on rivaroxaban and 12,311 on apixaban. In warfarin treated patients, the time in therapeutic range was 71.4%. After propensity score matching, there was no significant difference in risk of stroke or systemic embolism between NOAC and warfarin treated patients. Hazard ratios for major bleeding events were 0.63(95% CI 0.52-0.75) for apixaban, 0.74(0.62-0.87) for dabigatran and 1.06(0.92-1.23) for rivaroxaban, compared with warfarin. Conclusions: This study showed no difference between apixaban, dabigatran, or rivaroxaban compared to high TTR warfarin treatment regarding stroke prevention. However, fewer bleeding events were seen for apixaban and dabigatran, but not for rivaroxaban. Further studies are needed on the comparability of individual NOACs with respect to bleeding risks.
Background For patients with atrial fibrillation, non-vitamin K oral anticoagulants, or NOACs (dabigatran, rivaroxaban, edoxaban, and apixaban) have been proven non-inferior or superior to warfarin in preventing stroke and systemic embolism, and in risk of haemorrhage. In the pivotal NOAC studies, quality of warfarin treatment was poor with mean time in therapeutic range (TTR) 55-65%, compared with >= 70% in Swedish clinical practice. Methods We compared NOACs (as a group) to warfarin in non-valvular atrial fibrillation, studying all 12,694 patients starting NOAC treatment within the Swedish clinical register and dosing system Auricula, from July 1, 2011 to December 31, 2014, and matching them to 36,317 patients starting warfarin using propensity scoring. Endpoints were thromboembolic events and major bleedings that were fatal or required hospital care. Outcome data were collected from validated Swedish hospital administrative and clinical registers. Results Mean age was 72.2 vs 72.3 years, proportion of males 58.2% vs 57.0%, and mean follow-up time 299 vs 283 days for NOACs and warfarin. Distribution of NOACs was: dabigatran 40.3%, rivaroxaban 31.2%, and apixaban 28.5%. Mean TTR was 70%. There were no significant differences in rates of thromboembolic/thrombotic events or gastrointestinal bleeding. NOAC treated patients had lower rates of major bleeding overall, hazard ratio 0.78 (95% confidence interval 0.67-0.92), intracranial bleeding 0.59 (0.40-0.87), haemorrhagic stroke 0.49 (0.28-0.86), and other major bleeding 0.71 (0.57-0.89). Conclusion For patients with atrial fibrillation, NOACs are as effective for stroke prevention as well-managed warfarin but cause fewer major bleedings.
Low-molecular-weight heparin (LMWH) is often recommended as a bridging therapy during temporary interruptions in warfarin treatment, despite lack of evidence. The aim of this study was to see whether we could find benefit from LMWH bridging. We studied all planned interruptions of warfarin within the Swedish anticoagulation register Auricula during 2006 to 2011. Low-molecular-weight heparin bridging was compared to nonbridging (control) after propensity score matching. Complications were identified in national clinical registers for 30 days following warfarin cessation, and defined as all-cause mortality, bleeding (intracranial, gastrointestinal, or other), or thrombosis (ischemic stroke or systemic embolism, venous thromboembolism, or myocardial infarction) that was fatal or required hospital care. Of the 14 556 identified warfarin interruptions, 12 659 with a known medical background had a mean age of 69 years, 61% were males, mean CHADS(2) (1 point for each of congestive heart failure, hypertension, age 75 years, diabetes, and 2 points for stroke or transient ischemic attack) score was 1.7, and CHA(2)DS(2)-VASc score was 3.4. The total number of LMWH bridgings was 7021. Major indications for anticoagulation were mechanical heart valve prostheses 4331, atrial fibrillation 1097, and venous thromboembolism 1331. Bridging patients had a higher rate of thrombotic events overall. Total risk of any complication did not differ significantly between bridging (1.5%) and nonbridging (1.2%). Regardless of indication for warfarin treatment, we found no benefit from bridging. The type of procedure prompting bridging was not known, and the likely reason for the observed higher risk of thrombosis with LMWH bridging is that low-risk procedures more often meant no bridging. Results from randomized trials are needed, especially for patients with mechanical heart valves.


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Kevin Jeong
Paramus Office
Kevin Jeong has been in the Financial Services Industry for nearly 10 years and has been with CFS since 2015. He focuses on working within the Korean American community to help educate them on unique strategies and opportunities that can help maximize their future wealth and security. Kevin enjoys constantly meeting and working with new people because it allows for new experiences as everyone comes from different walks of life.
He is a member of Neighbor Plus and Family Touch Organizations of NJ, Pilgrim Mission Church, and NJ Korean Association.
Kevin is lucky enough to build a career with his wife, Ellen, who also works as a Financial Professional. In his down time, Kevin enjoys being outdoors going on hikes, playing tennis, bike riding, and traveling. Most of all, he loves spending time with Ellen and their four children.
- Life & Health
Financial Representative of Guardian


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Lowes 10% off coupon
Are you looking to remodel your home or just need some repairs done? As a Realtor I am able to offer my clients 10% off coupons from Lowes hardware store (maximum discount is $1000)! All I need is your name, address and email address.
Call or email me your information today!
Mike Carlucci 702-461-4422


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To deploy a virtual server, access your Cloud IaaS availability zone (see this article).
To create your new server, select vApps > Deploy New vApp from the left navigation menu.
vApp Template
Provide a name for your new vApp, for example 'Web Server', then select the vApp template you wish to use and click next. For more information about templates, see LINK
NB: vApp templates are split into availability zones - please choose the template that corresponds to your AZ. You can search for all templates in your AZ by entering the 3 letter short code (ADL/BNE/PER)
VS Resources
Click the name of the template to expand the options. Here you set the desired resources for your server. Set the label for your virtual server (within the vApp), assign the desired number of CPU cores and RAM, then select the data store for your VM. Default data store dictates the default location for your VM, including configuration files, and you can use the Data store for Hard disk 1 box to select the tier you wish to store the vm's root disk on (C: or sda).
Note that when selecting disk sizes, this can't be set below the recommended minimum by the software provider.
Select the network connection (if required) from the NIC 0 Connection field. Depending on your screen resolution, you may need to scroll down after clicking this box to see the list of options.
Guest Customisation
Guest customisation allows you to set several operating system parameters when the VM is deployed. To do so, click the name of the virtual server, then set the OS host name, ensure enabled is set to yes, select whether to automatically reboot to apply changes (generally yes), whether to allow the local admin account, and whether to use a generated or user-specified password.
Selecting Change SID will also allow the server to join a domain, if required.
To automate the installation of several applications, you can select from a list of recipes. At this stage, these only work on Linux based virtual servers.
To apply a recipe, drag it to the 'assigned for provisioning' section. To remove a recipe from the right pane, click the trash can.
As recipes are OS dependant, please ensure you select the correct recipe for your chosen operating system.
To review your configuration, click the vApp title to expand the details. At this point, we recommend disabling 'Disable guest customization after run', as this will allow you to quickly reset the administrator password, change networking parameters, etc. after the vApp is deployed. If you have left this enabled, you can disable it later through VM Settings (see LINK)
Once complete, click Deploy vApp. This will begin the process, first creating the vApp, deploying the virtual server, then running guest customisation and applying any recipes. Once all steps are complete, the vApp will be ready to use.


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Shop For Perfect Honeymoon Planning Items
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At midnight when fireworks will light up the sky upon Venice and the lagoon, you should be in St. Mark's Square to make your secret wishes, about love of course!
On that night Venice won't be the usual, there will be a magical and unforgettable atmosphere where everything is possible.
Stay in a romantic villa in the Riviera del Brenta, enjoy a special dinner in Venice and immerse yourself in the magical atmosphere of the fireworks in St. Mark's square. Private shuttle from the hotel to Fusina port will leave before dinner and after the fireworks a boat will wait for you at 1.30 pm.
Next morning you won't have to worry about the clock: you can enjoy breakfast in your room until 11 am.
A romantic stay longer than just one day!
The package includes:
2 nights in Junior Suite with Jacuzzi tub with chromo and ozone therapy
- Transportation to and from Venice by shuttle service, one-way 20:00 return at 02:00
Romantic dinner in Venice
Late breakfast in room (guaranteed until 10.30 am)
- New Year's day buffet brunch
City map
Late check-out (guaranteed until 1.30 pm)
Price per Person
Additional night €39 per Person
Discover all our proposals for the new year's eve
New year's eve 2020: experience the Venetian Villas atmosphere!HotelManager
A Candlelit dinner at a famous restaurant of the Brenta Riviera, Venice, will turn your new year's eve celebration into an occasion of romance and pleasure
New year's eve 2020: two nights accommodation, dinner in Venice and BrunchHotelManager
New Year's Eve 2020: Hotel package including 2 nights accomodations, dinner in Venice and... Fireworks in St. Mark's square!
New year's eve 2020: Romance, Relax & VeniceHotelManager
New year's eve 2020: Romance, Relax and... Venice!
New year's eve 2020: reaching Venice by boat to enjoy traditional fireworks!HotelManager
A magical and unforgettable atmosphere, the perfect background to make your wishes for the future.


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I'd do nothing but reading if I could (ok, maybe eat some great food, buy some fancy shoes between two books...oh, and spend some quality time with the gorgeous guy I married while I am on reading-break anyway...)
I like that this is a bit different from the usual PNR.
For example, the heroine has a hot, sex-based relationship with a guy who definitely won't be her long-term mate/partner.
And the heroine herself - she is kind of powerful, but not all-powerful.
She is rightly doubtful that she will be strong enough to battle the evil queen.
The world-building is original as there is a "human world" kind of beyond - so that this is like an alternative universe, but embedded in this world.
Kind of hard to explain. But it was good :-)
So far I really like this.


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To find books, DVDs, maps, sound recordings, manuscripts, and much more - everything except articles - use a library catalog.
OskiCat = most UC Berkeley libraries
MELVYL = all UC campus libraries, including all UC Berkeley libraries
What's the difference? more details here
For each item make sure you know the name of the physical library, call number, and whether or not it's checked out, library use only, etc.
Call numbers are on the spine of the book; learn how to read them so you can find what you need on the shelves.
No time to go hunting around the library stacks to find the books you need? Use OskiCat's request feature. Once you find the book you want, click (this button will only appear when an item can be requested). Authenticate yourself with CalNet, and follow the prompts. OskiCat will ask you where you want the book(s) delivered to. You will get an email when the books are ready to be picked up (usually within 1-3 days).
You can also use this button to:
The Northern Regional Library Facility (NRLF) is an off-campus storage facility for some library collections. NRLF materials are available to request in OskiCat.


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Founded by Dr. Priscilla Chan and Mark Zuckerberg in 2015, the Chan Zuckerberg Initiative (CZI) is a new kind of philanthropy that's leveraging technology to help solve some of the world's toughest challenges – from eradicating disease, to improving education, to reforming the criminal justice system. Across three core Initiative focus areas of Science, Education and Justice and Opportunity, we're pairing engineering with grantmaking, impact investing, policy work, and movement building, to help build an inclusive, just and healthy future for everyone.
We believe we can help build a future for everyone.
Our success is dependent on building teams that include people from different backgrounds and experiences who can challenge each other's assumptions with fresh perspectives. To that end, we look for a diverse pool of applicants including those from historically marginalized groups — women, people with disabilities, people of color, formerly incarcerated people, people who are lesbian, gay, bisexual, transgender, and/or gender nonconforming, first and second generation immigrants, veterans, and people from different socioeconomic backgrounds.
We are looking for CZI's first Investment Counsel to be part of CZI's Legal and Grants Team and an integral partner with our Investment Team. CZI's investment function is a new effort within the organization. The goal is to build a world-class investment portfolio that will deliver superior risk-adjusted returns to fund CZI's ongoing philanthropic operations over the long-term. The investment program pursues a "manager of managers" approach, scouring the globe to find extraordinary investment organizations that invest across a wide spectrum of styles and asset classes.
You will be responsible for both day-to-day management of legal issues related to CZI's investing and management of global funds, including its Donor Advised Fund and Private Foundation, as well as building CZI's legal systems, processes, and tools to support our Investment Team. You also will partner with CZI's Impact Investing Team and assist with CZI's general governance matters so that we have the systems in place to ensure everything is ticked and tied. The successful candidate will be someone with a long-term strategic and systemic approach as CZI is building for the long-term, while also possessing a proactive, entrepreneurial attitude, who rolls up his or her sleeves to build a world-class investment function form a legal perspective. If you are a mission-oriented, systems-driven thinker who enjoys creative problem solving and getting things done, and collaborating across multiple functions, you will fit right in. You will be part of the growing Legal and Grants Team working with educators, scientists, criminal justice reformers, and changemakers to help CZI achieve its ambitious mission of creating a future for everyone. Come help us reimagine technology-focused philanthropy! We can't wait to hear from you.
© 2018 Society for Corporate Governance. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
52 Vanderbilt Ave Suite 903, New York, NY 10017 Phone: 212.681.2000 | Fax: 212.681.2005


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Plot Outline:
In 1949, Julia Child is in Paris, the wife of a diplomat, wondering how
to spend her days. She tries hat making, bridge, and then cooking
lessons at Cordon Bleu. There she discovers her passion. In 2002, Julie
Powell, about to turn 30 and underemployed with an unpublished novel,
decides to cook her way through "Mastering the Art of French Cooking"
in a year and to blog about it. We go back and forth between these
stories of two women learning to cook and finding success. Sympathetic,
loving husbands support them both, and friendships, too, add zest. (courtesy
Won a Golden Globe, nominated for Oscar and BAFTA.
Another 8 wins
12 nominations.
Movie Website:
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In order to prioritise interventions for micronutrient deficiencies in China, the populations affected by iron and zinc deficiencies were assessed based on data from the 2002 China National Nutrition and Health Survey. The costs and cost-effectiveness of supplementation, food diversification and food fortification were estimated using the standard World Health Organization ingredients approach. Results indicated that 30% of children (<2 years), adults (>60 years), pregnant and lactating women, and 20% of women of reproductive age were anaemic, some 245 million people. Approximately 100 million people were affected by zinc deficiency (zinc intake inadequacy and stunting), the majority living in rural areas. Among interventions on iron and zinc deficiency, biofortification showed the lowest costs per capita, I$0.01 (international dollars), while dietary diversification through health education represented the highest costs at I$1148. The cost-effectiveness of supplementation, food fortification and dietary diversification for iron deficiency alone was I$179, I$66 and I$103 per disability-adjusted life-year (DALY), respectively. Data for biofortification were not available. For zinc deficiency, the corresponding figures were I$399, I$153 and I$103 per DALY, respectively. In conclusion, iron and zinc deficiencies are of great public health concern in China. Of the two long-term intervention strategies, i.e. dietary diversification and biofortification with improved varieties, the latter is especially feasible and cost-effective for rural populations. Supplementation and fortification can be used as short-term strategies for specific groups.
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The General Atomics Sciences Education Foundation (GASEF) provides funding to support K- 12 science education efforts that have countywide or at least multiple school district impact, predominantly in San Diego County where most employees of General Atomics and Affiliates work. Here science broadly encompasses Science, Technology, Engineering, and Mathematics (STEM) education. The Foundation favors support of programs that directly and immediately improve the STEM education of students, particularly those from traditionally underserved backgrounds. Funding decisions are made throughout the year, approximately every 3 - 6 months. Awards tend to range from $1,000 to $10,000; there are generally 6 - 15 awards per year. Please note that the GASEF does not fund for-profit entities.
In very rare instances, the Foundation may support individual schools or districts, but only if the opportunity is unique and sufficiently compelling. Prior to submitting a full proposal for a school or district, please send a short summary of the request to email@example.com.
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On June 18, 2007, I made a track that I originally called "Ignore me; I'm building an army." It has been through half a dozen modifications since then. When I discovered in seminary that the word Satan in Hebrew means "the accuser," I put some of my words over the track and called it Satan, which is actually on this site. But I think I've found a better application for the track by coupling it with a sermon Greg Boyd preached almost exactly 5 years after I made my track. On June 10th, 2012, he preached "The Sting," in which he laid out a compelling Christus Victor vision of the cross as a "sting" operation against Satan. So here then is "The Sting," track 3 of Danceable Homiletics featuring Greg Boyd:
Tag Archives: Christian music
Danceable Homiletics #2: "Don't Stand Up For Jesus" (featuring Jonathan Martin)
All right here's the second one. I just kind of got in the zone tonight. This is from Jonathan Martin's sermon "Don't Stand Up For Jesus" which he preached at the height of the Chik-Fil-A drama last summer. Jonathan's point is that we should stand with Jesus as He stands up for sinners against the people who want to stone them. So here it is:
Danceable Homiletics #1: Ring Them Bells (featuring Brian Zahnd)
My friend Bram gave me an epiphany today. I asked him what I should do to a trance track I made last night since he's from Europe and they actually listen to trance over there. He said why don't you overlay it with vocals from a Pentecostal preacher's sermon. And that was how the new genre of danceable homiletics was born. We'll see if it goes anywhere. Let me know if you have any favorite sermons you'd like me to trance-late into danceable form. Track #1 was created from an awesome sermon by one of my favorite preachers Brian Zahnd of Word of Life Church in St. Joseph, Missouri. It's called "Ring Them Bells."
Kayal ta-arog (Psalm 42 in hip-hop)
Kayal ta-arog al afike mayim is how you write "As the deer panteth for the water" phonetically in Hebrew. That familiar heartwarming hymn has its place to be sure, but if you read the remainder of Psalm 42 from which it draws the first line, then you see that its tone is off. The psalmist says tears have been his food and his enemies' taunts are crushing his bones. Those sorts of images call for a hip-hop song rather than a churchy sounding hymn. I'm preaching on this psalm this weekend. I will be rapping my own adaptation of it too. Lyrics are below. Here's the recording: Continue reading
Looking Back on 2012: Hip-hop and Piano Ballads
I wrote some songs this past year and posted recordings of some of the songs I've written in the past. I could use some encouragement if you think that any of this stuff is worth pursuing further. Because of the lack of response I've gotten, it's remained on the back-burner as a sort of lonely hobby. My honest concern is with not wasting God's talent and I haven't yet made peace with what I've made not going anywhere. I did the wannabe rock star thing about 8 years ago, and it was exhausting trying to "make it" in the secular music world. Had a band, played out in clubs, made an album, and I've still got 980 or so of the 1000 copies that were produced. We actually got 4 reviews in college and regional magazines, but our band broke up soon after the CD release party. If my music doesn't need to go anywhere, that's fine; I just wish I had some closure. My problem is that I've written songs that I thought God gave to me for a prophetic purpose, so to play them in the privacy of my living room honestly feels like I'm letting God down. I realize that sounds diva-ish but it's genuinely how I feel. I told God that if He wants me to reprioritize my life in order to pursue my music more aggressively, then I need some kind of sign. Anyway, here is a post in which I shared an album's worth of hip-hop and electronica tracks. And here is a post in which I shared videos of some piano songs I recorded at Goodson Chapel during the Duke pastor's convocation this past fall.
Jesus come back ('cause we've gotten off track)
This is Advent translated into hip-hop for Christians who are able to admit that we don't always do a good job of taking up our cross to follow Jesus and want to try again to serve our king by marching for His kingdom. Lyrics are below.
Crossing my arms at the Chris Tomlin show
About two-thirds of the way through Chris Tomlin's Fairfax, VA show last Friday, he joked that there was probably somebody in the crowd who was still standing with his arms crossed despite the overwhelming presence of the Holy Spirit in the room, etc. Well I was that guy. I tried to clap for at least some of the time, but a lot of the time I had my arms crossed because it was crowded and I didn't have any other place to put them. I also wasn't really feeling it. Continue reading


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Students of Grade 4 B conducted the morning assembly on the learner profile attribute "Principled". It began with a prayer seeking God's blessings. It was followed by a short skit, which depicted how honesty and integrity can help us lead a better and fruitful life. A short speech highlighted the fact that being principled can help us to be an honourable person who gets respect from others. This was followed by a melodious and inspiring song that sought to motivate the students to be principled in life. The thought for the day summed up the theme stressing on the fact that all that we do is ultimately a self portrait of ourselves and so we should autograph our work with excellence.
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Stay on target
Game of Thrones is back for another season, and the return to Westeros has been pretty great so far. And given how beautifully the show is shot, some might want to immerse themselves completely in the Seven Kingdoms. Sadly, we can't step inside our TVs yet, but there are other ways to dive deeper into Game of Thrones' world. The latest comes from Duolingo. The popular language-learning app recently added a High Valerian lesson. If you've ever wanted to warn someone of approaching dragons (or just complain about your drunk uncle while he's in the room with you), you can now do it in the most appropriate language possible.
The lesson is structured like all Duolingo lessons. You start with the basics, a few nouns and maybe a basic verb, and build up to more complicated sentences. If you spend five minutes a day with the app, you'll go from simple sentences like "I am" to complex ideas like "the dragon is eating my daughter." (It's a common problem among native High Valyrian speakers.) And make no mistake, Valyrian isn't a simple code or cipher. It's not a just matter of switching out English words for Valyrian ones. Valyrian is a real language with its own unique grammar and gender system.
Valyrian was created by linguist David J. Peterson, who also created the Dothraki language for the show. Peterson is the person who designed the High Valyrian lesson for Duolingo. I got a chance to talk to him about the lesson plan and how he built the new language. When we spoke, he was still finishing up the course. He said creating a High Valyrian course was a rigorous process, but no different from creating one for any other language.
The way Duolingo works is the language is broken up into a skill tree. You start out with some very basic skills (like present tense verbs), and work your way up to things like semantics. When you, as the learner, correctly translate a sentence from High Valyrian into English, the app adds the words in that sentence to your skill level. That's how it determines your command over the language. On his side, he has to pick the words he wants each lesson to teach, and turn them into sentences the student will be able to work with at that point in the course.
Sometimes the hardest part, he said is coming up with things to say. With countless words at his disposal, stringing them together into a meaningful sentence can prove difficult. "I have a lot of sentences about turtles," Peterson said. It might be a while before you start speaking lines from the show. At first, the most complex sentences you'll learn are "the man is sleepy" and "the woman is sleepy." In the final lesson, you're saying things like "Valyrian is my mother tongue."
So how do you teach a language that no one on Earth natively speaks (or ever spoke)? Peterson has studied language for yeas, and points out that languages are just systems. Creating a new system is entirely possible, you just have to define what the rules are. By studying human languages, Peterson has a good idea of what people like to do with language and what they're capable of. "All language on Earth are equally capable of expressing any thought that a human being can express. They are equally capable of translating an idea from one language to another." Peterson said that grammatical structures and emphases changes from language to language, and some may have to use more words, but they can still communicate the same idea.
Creating a language, he says, is all about deciding how you want to say everything that needs to be said. If done right, it shouldn't match any other language system that's ever existed. It can correspond for a sentence here and there, but it should be it's own thing. To create Valyrian, he had to decide how descriptive he wanted single nouns to be, and when adjectives should be added. He then did the same for verbs and adverbs, and all other parts of speech. Peterson compared creating a language to starting a game of Minecraft. You start with nothing and build a little bit at a time until you have something recognizable.
What's it like to speak High Valyrian? Unlike many western Earth languages, the most important part of the sentence is at the end. Adjectives come first, as do relative clauses, with nouns and verbs at the end. Peterson gave an example. "The man I talked to yesterday has a nice cat," in Valyrian would be literally translated as "The yesterday I talked to man a nice cat has." For an English-speaker, that may take some getting used to, but someone who speaks Japanese or Turkish will pick it up easily.
"It's a highly inflectional language," Peterson said. "Which means that it's got a lot more tenses and aspects that are expressed on the verb than English does… it also has a lot of cases that are inflected on the noun. In English, all the cases that High Valyrian has are replaced with prepositional phrases. So in English, if we're talking about a mountain, "mountain" stays the same whether it's the subject ('the mountain is big') or the object ('I see a mountain'). Valyrian would have a different form for that." Valyrian also has different forms for prepositional phrases. So "to the mountain" has a different noun form than "of the mountain." There could also be a single word for hitting someone with a mountain (using it as a weapon) in Valyrian. That may be the best case for learning High Valyrian I've ever heard. In what other language can you hit someone with a mountain?
In that way, Russian and Turkish speakers will feel at home with High Valyrian. I asked if there's an Earth language High Valyrian is closest to, and he said probably Latin. "Valyrian has more cases than Latin, but it has the same number of verb forms. And neither language has articles. I guess that's a closer correspondence than anything I can think of offhand."
Peterson created both Dothraki and High Valyrian for the show. Dothraki was created as part of a linguistic competition. Whoever created the best Dothraki language got to work on the show. That was their application process. Peterson had about 50 Dothraki words to work with from the books. He was able to build out from those into an entire language. With Valyrian, though he was now officially working on the show, he had even less to go on.
"There were really only two phrases. Valar Morghulis and Valar Dohaeris. Those were the only phrases. After that, there was one or two words here and there, like 'valonqar,' which we know means 'little brother,'" Peterson said. The only other clues he had to work with were the Valyrian derived names, like Daenyres and Illyrio. The names informed him as to what Valyrian words sound like, and how they're gendered. The two phrases allowed him to create the verb system. "Those two phrases were my sole inspiration for the rest of the Valyrian language… It was specifically because those two phrases were translated as 'all men must serve' and 'all men must die. It wasn't just a simple use of the present tense or something there. What that indicated to me was if there's some sort of inflection there that gave you a tense form modality that translated as 'must die' and 'must serve,' then there must be other modalities and tenses as well… I used that information then, to generate the rest of the verb forms."
The most interesting part of High Valyrian to me was the gender system. In High Valyrian, a noun's gender isn't tied to sex (like it is in Spanish, with its masculine and feminine nouns.) The gender system grew out of the fact that "Valar" was translated as "all men." That gave Peterson the idea that High Valyrian has different gender forms for definite and indefinite plurals (meaning things that can be counted vs. things that can't). That led to the Valyrian language having four genders. The countable nouns have solar and lunar genders, while the mass nouns have aquatic and terrestrial genders. The lunar and aquatic genders are essentially the same, but they refer to different types of nouns. Same with solar and terrestrial. Peterson was very clear that none of the genders are meant to be taken as masculine or feminine. In fact, man, woman, boy and girl are all expressed in the lunar gender. Peterson said he loves playing around with gender in languages, but he's not a fan of the sex-based genders you see in European languages.
So what's the goal here? Why have an entire language course for a fictional language that won't help you at all if you travel abroad? According to Peterson, the answer is simple: Language is fun. That's why he says people should learn bits of other languages and play around with them.
"Even if your end goal is not to be fluent, it's fun to dip into a new language and learn a bunch of stuff for a year or a half year or something," he said. "I think people think of it as entirely utilitarian, as a tool, or they think of it as an obstacle or chore. What it really is, is human beings' greatest invention of all time. Nothing that human beings have ever accomplished has been done without language. And I think it's cool to celebrate that." Peterson says that even if someone dabbles around in High Valyrian once and never touch it again, he just wants them to have some fun with it. "If they come away with a better appreciation of what language can be, or just a sense that it can be fun, that makes me happy.
You can learn High Valyrian now on Duolingo's website, and it's coming to the app once its beta concludes.
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Rhinoceros Hornbill
Buceros rhinoceros
The Rhinocerous Hornbill is not just the national bird of Malaysia but also the state bird of Sarawak, a Malaysian state on the island of Borneo.
The Bornean Dayak people believe it to be the 'chief of the worldly birds'.
It is the largest of all the hornbill family, around the size of a swan – 36cm to 48cm in length.
During mating season, the female needs to find a male she can trust completely. This is because when she lays her egg she will retreat to a hollowed out crevice in a tree and locks herself in by sealing up the hole with a paste of fruit, mud and faeces. She will stay in there for the entire incubation and rearing period and her mate will be responsible for bringing both her and the young food. The rhinoceros hornbill eats fruit, insects, small reptiles, rodents and smaller birds.
The large ornamentation on top of the Hornbill's beak is called it's casque and is made from the same stuff that makes our fingernails – keratin. The structure of the casque is mostly hollow, and is thought to amplify the hornbill's calls so they can be heard all throughout the rainforest. It faces threat from humans hunting it for it's meat, casque and feathers.


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How to Start a Dragon Fruit Cactus From Seed
The cactus germinates with two leaves -- the only true leaves it ever has.
Dragon fruit is the edible fruit from the Pitaya cactus, a member of the Hylocereus genus. It is called dragon fruit for the scales on the outside of the fruit, which remind people of a dragon. While the cactus must be protected from freezing, it makes an attractive climbing houseplant in colder areas. It is easy to start from seed.
Look online for seeds. If you can't find seeds, buy a dragon fruit, which can be found at many Asian markets. They come in yellow, red and magenta colors.
Cut the fruit in half. Scoop out a teaspoon of pulp, making sure you get some of the black seeds. Mash the pulp in a small amount of water to separate the seeds.
Clean the gelatinous pulp from the seeds. You won't need many seeds, because the germination rate is high. Enjoy the rest of the dragon fruit as a snack.
Fill a shallow container with a planting medium made from equal parts seed-starting mix and sand. Moisten the mixture. Sprinkle the seeds on the top of the medium and barely cover them with sand. Seeds need light to germinate.
Place the container in a plastic bag to retain moisture. Set it in a warm spot that gets plenty of light. Check daily; seeds start germinating anywhere from one to 14 days after planting. After germination, remove the plastic bag.
Do not overwater the young cacti. After several months of growth, pot each small plant in its own container.


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Some sneakers become so great through time that it travels beyond a generation. Along the way, they bring drastic changes to the likeness of the mass. The birth of Nike Air Max 95 was such a story. It has been two decades since Nike debuted the Nike Air Max 95. But the sneaker is still running strong when it comes to rule the street style even in today's standard. A sneaker that is so great that so many myths and meanings have been circling it in diverse subcultures. It paved a new era for performance running sneaker. The success of the sneaker later gave birth to many famous Air Max sneakers like the Air Max 97, Air Max 98 and others. The Nike Air Max 95 is to some to desire and to some to deride.
Nike has always been a very promising when it comes to patching up with and cultivating the influential designer minds of every era. Nike's sneaker design proves that the boundaries do not restrict its design associates. Back in the past, designers like Tinker Hatfield, Bruce Kilgore and many other top names were working with Nike. This culture continues to today's era as the talent like Virgil Abloh, and Samuel Ross is now the front line of fashionable sneaker design with whom Nike has created a good bond. And it has benefitted Nike in as their sneaker lines are getting more excited attention with growth in quality also. Nike has always been supportive of young designer and open to their ideas. One such celebrated name is Sergio Lozano, who started working with Nike back in the '90s. Nike allowed him to venture his ideas on a new sneaker and thus the legendary Nike Air Max 95 born.
Lozano was working on the ACG before the Air Max 95. His office had a lake facing the window, and while one day relaxing during work, a new sneaker concept came to him that he described the shoe would be resulted by erosion. At the time when basketball shoes were the ruling the fashion era, Sergio Lozano's brilliance and confident design paid off Nike's plan to reinvigorate their running shoe lines. The 1995 release Nike Air Max 95 OG was inspired by human anatomy. The outsole reflects on the human body's spine structure while the lacing system takes inspiring notes from the ribs. The upper has a layered synthetic suede construction with compression moulded that will give maximum support for a long time. With the grey hue and the neon yellow, the colour palette represented Nike's racing heritage. The sneaker was so strong and bold in design that even with the minimal Swoosh logo Nike Air Max 95 mens announced that only Nike could be this much innovative in the sneaker world. The ladies also embraced the fashion with the Nike Air Max 95 womens. The mesh overlays delivered the right amount of ventilation on the entire top of the foot.
Nike Air Max 95 has been heavily embraced by hip-hop society. Rappers like Eminem, Gucci Mane and many more were a fan of the sneaker, and some even mentioned it on their hit numbers. The sneaker also made into the world of comics. As demand changes over time, Nike brought a new view on the AM 95. With Nike's desire to break new boundaries, they slightly altered the classic AM 95 and created a more slim looking Nike Air Max 95 Ultra SE still featuring the traditional two Air Unit system but in a more sleek design. Among all of the 95's the Ultra SE gives you the most lightweight and cushioned experience you will ever get.
Over the Nike revisited their legendary Nike Air Max 95 in many iterations with the difference in contrast. We have seen Nike Air Max 95 black and Nike Air Max 95 green to the important ones. But for those who crave the OG vibe, the Nike Air Max 95 Essential pair is the ultimate one that stays true to the 90's first drop. This sneaker doesn't touch a stitch but keeps Lozano's vision to the purest.
Nike Air Max 95 has become an age-old fine wine. The sneaker's design, innovation, aspiration; all of them have placed it to another level. What started released in 1995 now set to live long more than two decades. So, don't forget to race the mile with your favourite pair of Nike Air Max 95.
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Heart Health
Typically, we live a rushed life and our health takes a back seat to our daily routine. We don't have time to prepare healthy meals and we ignore risk symptoms, even those associated with heart disease. As a pharmacist, I can testify to seeing an alarming amount of patients daily with either an expired prescription, uncollected repeats of cardiovascular medication and simply patients who try to reduce medical expenses. In reality there are many articles and campaigns on being healthy but we would like to not only promote heart health this month but to encourage and assist our community in knowing their score and living a quality life without everyday hassles. In co-operation with South Africa's leading cardiovascular generic medication provider, Pharma-Dynamics, we would like to show patients how to look after their hearts in the easiest possible way. We need to create awareness not only of heart disease but the related health risks and how to possibly prevent it. Having an imbalanced lifestyle, being stressed, not getting enough nutrients and even not taking medication correctly; are all factors contributing to a decrease in health.
Firstly, we need to look at our family history. Diabetes, high or low blood pressure and past cardiovascular disease all have a risk since some of these could be inherited. Secondly, we need to look at current health. If we have underlying conditions already, we need to focus on how to keep it under control at all times. When you have high blood pressure, cardiovascular disease or cardiomyopathy; you could experience various symptoms such as: possible nausea, irregular sweating, chest pains, shortness of breath and dizziness. Lastly, we need to look at our lifestyle. Identifying all possible factors that could lead to a decrease in heart health is imperative. Heart diseases are commonly caused by poor lifestyle choices and typically not knowing whether you are at risk.
There are various ways to ensure that you take good care of your heart. – Avoid smoking and second-hand smoking. Cigarettes contain harmful chemicals that can damage your heart and lungs. Smoking around children could have a long-term effect on their health as well. – Exercise regularly. We simply do not have the time to go to the gym anymore. We all live in the fast lane and we compromise wherever possible. Making small changes in the ways we do things could assist in ensuring we get the most out of our days such as taking the stairs; taking your pets for a walk and even quickly sweeping a room. – Avoid eating fatty foods as much as possible. There is no need to buy all your meals ready-made. Simply adjust your portions, reduce your salt levels, including all of the food groups and avoiding take-away meals is already a good start! Make sure to snack between smaller meals and avoid overeating. Eat before 7pm and avoid sparkling soda drinks. Drink more water. – Have a screening test at least once a year to know your scores. Most medical aids allow for one test per anum per member. Make the most of your money's worth and get tested every year for cholesterol, blood pressure and diabetes. – Take your medication correctly. Most patients on cardiovascular medication do not adhere to the stipulated doses and do not collect their medication on the correct days. Check in with your health care practitioner every six months to ensure your current medication is still working. – Limit alcohol intake. – A healthy mind is very important. Depression and anxiety also have negative effects on our health. Stress causes release of stress hormones and prolonged exposure to these elevated levels puts a strain on the heart. Having a good support system is important when it comes to everyday life. Engage in relaxing activities at least twice a month. – Diabetes increases the risk for a stroke or heart attack by two to four times. Take special care if you are diabetic. Heart disease is the leading cause of death in diabetes patients.
Some interesting facts provided by Pharma-Dynamics: Cardiovascular disease is the leading cause of deaths in SA after HIV/AIDS. One in five deaths in SA are heart disease and stroke related and over 200 deaths occur daily in this category meaning there are over 82000 deaths per year related to heart and cardiovascular disease.. Only about 40% of patients have their blood pressure under control with medication. There are over 6 million people in South Africa with High blood pressure. Four out of ten adults older than 25 have high blood pressure with 50% of them unaware. Up to 70% of women and one third of men are overweight and obese leading to diabetes and increasing the risk for heart disease. The risk of a stroke doubles every decade after the age of 55. People who don't get enough exercise have a 50% increased chance of heart disease and stroke.
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