text:
TruckingOffice or QuickBooks?
We've created a little test we call TruckingOffice or QuickBooks. Let's see which program is going to work best for you.
Is accounting the only thing an owner-operator needs a computer program to do?
Obviously not. In this 21st century, there's software to manage many aspects of a trucking business.
We know your accountant wants to use QuickBooks for trucking businesses, because it's the program that they know and love. QuickBooks fits their business. But does it fit ours?
Using an accountant for your billing, taxes, and other financial tasks is smart. We know that. In fact, we've got a way for you to export data to QuickBooks for your accountant. But you didn't become a trucker to push paper. But it's a necessary part of the work if you want to be paid. There's no question that QuickBooks is the standard for small business accounting. That it's the best out there. But is it the best for us?
We say no. It's not the best for us truckers. It may be best for an important part of our business, but it's not the only component of computer software we need. That's why trucking management solutions exist – because we need software specific to our business.
QuickBooks is not specific enough.
If you've worked with an accountant, chances are you've gotten a Profit and Loss Statement. If you've ever gone for a business loan to buy equipment, the banker probably asked for it.
All businesses have a set of reports that show critical information about the state of the business. Most industries have specific reports that indicate growth, loss, profits, etc. Trucking is the same.
Here's the problem with QuickBooks for trucking. It's simply not specific enough. There's no way for QuickBooks to report
- costs per mile
- expenses per mile
- revenue per mile
because QuickBooks doesn't track miles. There is an app that's called a Mileage Tracking App for QuickBooks, but it tracks trips. it doesn't track deadhead miles, it doesn't track bobtail miles, it doesn't track miles per state.
And let's talk state miles for a minute
Using QuickBooks for trucking ignores the biggest headaches we truckers face: the IFTA.
We've heard about some truckers who have tried to track their miles per state on QuickBooks. They now use TruckingOffice TMS because it's complicated on QuickBooks – complicated to enter and complicated to get correct results. This tax is one place you must be confident you've got the right numbers!
That IFTA sticker on your cab means you're paying taxes every quarter. Underpay and the government will fine you. Overpay and kiss that money goodbye. QuickBooks? It's not going to compute those numbers for you.
IFTA is too important to use a software that isn't programmed to compute it.
TruckingOffice or QuickBooks? TruckingOffice.
That's an easy choice.
TruckingOffice trucking management solution was designed with a trucker on the team. From the very beginning, the IFTA was as much a focus as the billing module. We've refined the IFTA report to help you be confident that the numbers are right. We update our databases of the jurisdictions tax rates as early as we can to let you know what you're going to pay. You can even use our report to figure out where you need to buy fuel to reduce those IFTA payments.
Is QuickBooks going to help you figure out your payments? No. Can it suck a lot of time that you could be using in more productive ways? Yes. If figuring out your IFTA taxes takes more than 20 minutes, you're spending too much time on it. With TruckingOffice, we have a specific report that will immediately tell you exactly what you owe. You can make those payments and get on with the business of trucking. Or your family. Or your dog. Or whatever you want.


text:
|The largest independent, non-commercial, consumer-oriented resource on the Internet for owners, collectors and enthusiasts of fine wristwatches. Online since 1998.
Vintage Heuer Discussion Forum
The place for discussing 1930-1985 Heuer wristwatches, chronographs and dash-mounted timepieces. Online since May 2003.
I agree.
I would have thought that reputation is absolutely everything in his business.
We are willing to part with significant sums of money for these parts because we know how difficult they are to obtain. It is often impossible, or at least extremely difficult, to determine whether the parts that are for sale are exactly as described and therefore it is necessary to rely on the reputation of the seller.
I bought some parts from this seller that I have yet to have my watchmaker fit and I am now a little anxious.
If this was not resolved, at least to the partial satisfaction of the buyer, then I would hesitate before buying anything from this seller again.
: Hello all,
: I had difficulties with that seller too.
: With the help of the forum (tanks to Jeff), hopefully I could have
: a refund.
: I understand that he can make mistake, but if he wants to hold his
: reputation, he has to refund the non Rindt parts.
: That is my point.
|Chronocentric and zOwie site design and contents (c) Copyright 1998-2005, Derek Ziglar; Copyright 2005-2008, Jeffrey M. Stein. All rights reserved. Use of this web site constitutes acceptance of the terms of use.

subset: commoncrawl


text:
Mdina Full Day Tour
Tour to the old capital of Mdina, walk through the silent city streets ,visit the imposing bastions to admire a panoramic view of the island. On leaving the city through the Greek gate stop at the catacombs. Proceeding to Dingli Cliffs. Then to Craft's Centre Ta'Qali, Mosta Church and finally to the botanic Gardens of San Anton.
|360 €
|175 €
|380 €
|185 €
|410 €
|225 €
|485 €
|300 €
|560 €
|375 €
Policies & Procedures
- 1. Unless otherwise indicated, the prices shown, cover transport to places of interest but do not include entrance fees and lunches.
- 2. All prices are inclusive of local taxes and are subject to change without notice.
- 3. Maltaairporttransfers is not responsible for any loss of property on its services or left behind on its coaches or vehicles. In spite of our staff's efforts, no guarantees can be made for recovery.
- 4. We reserve the right at our discretion to cancel a service, in which event you shall be refunded the price of your ticket.
- 5. Maltaairporttransfers shall not be liable for any default due to any act of God, lock-out, flood, police road blocks or operations, road accidents, industrial dispute by third parties, traffic delays due to local events taking place, natural disasters, road closures or hazards, demonstration or marches or any other event beyond our control.
- 6. All tours and excursions are to be accompanied by a Malta Tourism Authority Licensed Guide, as requested by the Maltese Law.


text:
Storm Troopers for Wendell
Dear Friends and Family,
I'm excited to tell you that on Sunday, September 15th, I will be participating in the Les Turner ALS Foundation's ALS Walk for Life. This is the 3rd year that our team "Storm Troopers for Wendell" has participated since I was diagnosed with ALS in 2016. As this disease has progressed, my family and I are continually grateful for all the support we receive from the Les Turner ALS Foundation. They provide a nurse that comes to our home, monthly support group, the clinic we attend, equipment we might need, research and so much more! They are committed to supporting people living with ALS and their family every step of the way in their difficult journey with the disease.
Just as the Foundation is committed to supporting people living with ALS, I'm committed to raising awareness and funds for this important cause.
But, I can't do it without you. There are three ways you can help me:
1. Join me at the Walk for Life.
2. Make a donation and help me reach my fundraising goal.
3. Spread the word! Share this email with your friends and family and ask them to join you in supporting me.
Thank you in advance,
Wendell, Theresa, Elizabeth, Ellen & Emily
(NOTE: If you need help signing in or donating online, please email Susan at email@example.com or call 630-347-8714.)


text:
BCV Financial Solutions is a respected financial services firm based in Frankston. We are holding a free Property Investment Seminar on March 23rd - where you have the opportunity to hear from our experts in Financial Planning, Accounting and Real Estate.
We will cover:
How to start investing in property
Buying property with your Superannuation
The best places to invest and "property hotspots"
Generating passive income through property
Investing for retirement
Negative gearing
...and much more.
Speaker Line Up:
Sean Limpens Director, BCV Financial Solutions
Sean is a CPA and Director at BCV Financial Solutions. He has extensive accounting and taxation experience and is also a qualified mortgage broker.
Michelle Roberts, Advisor, BCV Financial Solutions
A highly experienced Financial Adviser, Michelle possesses a wealth of knowledge on using your Superannuation to purchase an investment property, the importance of liquidity insurance and all matters relating to personal financial planning.
Andrew Gabriel, Property Invesment Advisor
Andrew has been successfully advising investment property clients since 1989. He has extensive experience in commercial and residential investment property portfolio management and has helped countless people achieve their goals with tailored property strategies that work for them and their individual circumstance.
Places are limited. Book online today or call (03) 9781 4533 to reserve your place.
**ATTENTION** The event location has been moved to the Best Western, Frankston International, 383-389 Nepean Highway, Frankston. The room is located on level one, which is accessible by stairs only.


text:
Responsive Web Designing in Chandigarh – Call: +91 9915 337 448
Latest and Most Popular CSS Frameworks Cover – Twitter Bootstrap 2, 3 versions, Foundation CSS, Pure CSS, HTML5, CSS3 and jQuery
Training Duration: 30 days, 45 days Training
Responsive Web Designing Training with Live Projects + Certifications
100% Practical, Personalized, Classroom Training and Assured Job.
Webtech Learning is the professional and advance institute for responsive web designing in Chandigarh, Mohali and Panchkula with live projects and 100% job placement guarantee. With my course you can start your career as a web designer Specialist as well as you can earn money online through freelance.
Webtech Learning brings you training in Responsive Web Design Programming . We offer full courses in Responsive Web Design through which we train students. Now you can attend these courses in the cities of Chandigarh, Mohali, and Panchkula.
Webtech Learning Provide Three type of Responsive Design Training:
1) Fully Responsive Web Designing (RWD) (Mobile First)
2) Simi Responsive Web Designing
3) Through Media Query
We also cover Responsive Web Design Through Advanced CSS Frameworks:
1) Twitter Bootstrap 3. 4 versions
2) Foundations CSS
3) Pure CSS
4) Base CSS
5) Responsive CSS Frameworks
6) LESS / SASS CSS Frameworks
many more..
Course Name
Responsive Web Designing Training CHD
30 days – 45 days, Crash Course
Batch Timing
7am to 9pm
html, css, html5, css3, SEO, javascript, Jquery, Advanced CSS media queries, responsive ux, responsive mobile web designing.
Who can join
Knowledge of a any programming language, students, BCA, MCA, Msc (IT),Bsc(IT), B-Tech etc
|Chandigarh, Panchkula and Mohali with near sector 34, 17, 15 IT PARK
Responsive Course Objectives
After attending our Responsive Web Design course, you will know:
- The current mobile market – mobile devices and mobile browsers
- Basic beginner's to the advanced professional level.
- Techniques for creating flexible, responsive web sites using media queries
- Best practice design for mobile devices
- How to use tools & resources for testing
Responsive Web design is the advance technique that recommends that design and development should react to the user's behavior, experience and environment based on screen size, platform and orientation means a design fits for all devices like Iphone, Ipad, Tab, Retina display. The practice consists of a mix of stretchy grids and layouts, images and an intelligent use of CSS3 media queries.
In receptive the user switches from their laptop to iPad, the website should automatically switch to accommodate for resolution, image size and scripting abilities. In other words, the website should have the technology to automatically respond to the user's preferences. This would eliminate the need for a different design and development phase for each new gadget on the market.
Responsive Web Design Training Course Syllabus:
- Mobile market overview: devices, operating systems and browsers
- One web vs. mobile web
- Mobile First
- Progressive enhancement
Getting started
- How mobile devices display web pages
- Screen resolution: CSS pixels vs. device pixels
- The viewport tag
- The Safari auto-zoom bug
- webkit-text-size-adjust
Responsive web design
- Flexible grids
- Flexible fonts
- Flexible images & background images
- Common screen sizes – resolution breakpoints
- Media queries
Content delivery – know your audience
- What content do people need?
- How people browse – mobile mindsets
- Browser dimensions, bandwidth & context
Design tips and best practice
- Displaying & hiding content
- Simplifying navigation
- Linearizing layouts
- White space
- Font sizes, faces & spacing
- Text readability
- Minimising input from user
- Making calls from links
- Linking the full version of a site
- Validation and markup
- In-browser testing
- Creating a suite of representative devices
- Online & offline emulators
- Testing services
Contact Details:
Surjeet Singh (14+ year industry experience) – view profile
Mobile Number
Online Email
Contact Place
Webtech Learning – Web Education Academy
SCO 177, 2ND FLOOR, Sector 37-C, Chandigarh, India
Related Courses
WebtechLearning - Web Education Academy
ISO 9001:2008 Certified Academy
Professional Training + with Live Projects + Certifications+ Job
Call for query: +91 9878 375 376, +91 9915 337 448 , Skype: webtechlearning
Note: you can meet your trainer, get demo class before joining the Course.


text:
When I was growing up, my parents made it a point to take a summer vacation somewhere around the country every year, but one place we never made it to was the Grand Canyon. I'm glad to say that I finally made it to this must-see national park with my own family (including my brother).
We had a terrific trip. Although it's no doubt a cliché, words and photos do little justice to the experience of actually being at the Grand Canyon. Viewing it in person is absolutely breathtaking and awe-inspiring.
Get Your Kicks on Route 66We opted to take a popular Grand Canyon Railway package, which starts in Williams, Arizona, a town that touts itself as "the last town to be bypassed by Route 66."*
Fred Harvey Company, one of the first chains of hotels and restaurants, famous for its "Harvey Girls.")
The operators have quite shrewdly also positioned the railway as a "green" alternative to driving and polluting the Grand Canyon, claiming that it is responsible for keeping 50,000 cars from the park. These efforts—which also encouraged the use of reusable water bottles—is in line with the park's efforts to promote green living and preserve the natural wonder of the Grand Canyon.
Though Williams is nearly a straight-line north-westerly drive from L.A., rather than take the 7.5-hour drive, we opted to fly to Las Vegas, stay there for a few days, then drive to Williams in a rented car. Vegas is about three-and-a-quarter hours from Williams and Phoenix is about an hour closer, being the closest major airports to Williams and the Grand Canyon.
Grand Canyon Village; and a return trip to Williams the following afternoon, with one final night at the Grand Canyon Railway Hotel. Given that the package included two breakfasts and dinners at the buffet restaurant at the Williams railway hotel, the train trip and entertainment, and a brief coach bus tour at the Grand Canyon, I have to say the cost of the trip was certainly very affordable. The company took care of our luggage the whole way, transporting them from one hotel room to the other the entire way, so we never had to worry about them. The package also included a cowboy gunfight at Williams and a "train robbery" on the way back–which featured the train robbers running alongside the train on their horses. All the employees on the tour were incredibly nice, welcoming and upbeat.
The Grand CanyonAs mentioned, our package included a coach bus tour of the Grand Canyon upon arrival. Frankly, now that I have a better understanding of the park, the bus tour was probably unnecessary, but it was nevertheless a good way for first-time visitors like ourselves to get oriented and learn about the park. After that, we were on our own.
The canyon is about 277 miles long, 18 miles wide at its widest, and about a mile deep. No doubt one reason the Southern Rim of the canyon is the most developed and visited is because of the trails you can take down to the bottom: the Bright Angel Trail and the South Kaibab Trail. They are about 9 miles down, taking you more than 4,000 feet (the canyon's elevation is about 7,000 feet). Hikers are not advised to attempt the hike in a day, especially since one has to remember the hike back is uphill. Hikers have the option of staying at a lodge called the Phantom Lodge at the bottom (or, presumably, camping). But you can certainly go as far down on the trail as you like and then turn around and come back.
The first day we stayed out long enough to watch the sunset—understandably a popular pastime as many people settled down around us to do the same. Returning back to the village, we found the "upscale" restaurants had 90-minute waits and decided to just hit the food court at our lodge. Not as good as a sit down restaurant meal, but at least we were able to order food quickly and replenish ourselves.
The next day we spent exploring the western side of the Canyon. It was at that time that my brother, son and I (while my wife and daughter slept in) discovered we were within walking distance of the rim and the main trail heads.
We visited at the perfect time—it was spring break for my kids and the weather was clear and comfortable, being neither too warm or too cold. While there were many people there, I wouldn't consider it crowded. I can only imagine what it's like in the summer at the height of tourist season—I overheard a bus driver say that the park had 17 permanent suttle drivers and, during the summer, employed as many as 54 to accommodate the crowds.
I've never had love of heights—while it's not debilitating and being at the Grand Canyon wasn't a particular problem for me, I certainly wasn't as brave as some folks who were able to rather non-chalantly go fairly close to the edge. Nevertheless, I have to admit, just starting down one of the trails was enough to bring my heart to my mouth—and in any case my son refused to start down anyway. (My daughter was more than game, but since no one else was willing, she was denied the chance—I told her she could do it on her own trip!)
While there are fences or walls at the main vista points, some of them would offer little protection for young children; and the main trails and other points have no such protection at all. But it's all a matter of common sense and a little bit of caution. (Googling such incidents, I found that the park averages about 3-4 deaths a year from falls, and another 8-12 or so a year from "environmental factors" like dehydration and sunstroke).
Hoover Dam
While there are several levels of tours visitors can take, we simply opted for the museum tour which includes a room that offers a nice overlook of the dam. And, of course, we made sure to walk across the dam that includes the state line dividing Arizona and Nevada.
The Hoover Dam was, in its way, as breathtaking and impressive as the Grand Canyon. Completed in the midst of the Great Depression, it is truly an engineering marvel (it was even completed two years ahead of schedule) that represents an apex of American ingenuity and industriousness that has stood the test of time.
Visiting the Hoover Dam also proved to be a nice bookend to our Grand Canyon trip since, of course, the Hoover Dam straddles the Colorado River, so it was a treat to point out to the kids that we were seeing the same river we saw at the Grand Canyon.
In all, our trip went smoothly and safely, and was a memorable vacation as American as apple pie!
* Historical Route 66, made famous by legend, song (and TV), was displaced with the rise of the Interstate Highway System and Route 66, which runs through the town, was the last leg to be replaced by the I-40 in 1984. Route 66 was officially decommissioned in 1985. My wife reminded me that Santa Monica, California, near where we live in West L.A., was the west coast terminus of Route 66. Signs and souvenirs at the Santa Monica boardwalk capitalize on this connection.)
Below are additional photos from our trip:
To see all the photos, visit the following links:
|You can see a mule train of riders in the center of this photo


text:
It's fascinating the way hair reinvents itself each decade. Just when we thought perms would never resurface, Olivia Munn and Julianne Hough made us consider getting modern, semi-permanent waves. And leave it to Alexander Wang to make claw clips a street style accessory again in 2018. Who knows? Perhaps even our worst middle school 'dos will one day grace the cover of Vogue. Hair is anything if not fleeting, and we deeply anticipate how styles that seem so far removed are reincarnated.
Yet there are those beauty trends that never again see the light of day. Perhaps they aren't safe for our strands or are simply unpractical, and to those, we call for a moratorium. Curious which of these trends celebrity hairstylists would rather leave in the past than make their way into 2019, we asked them for their honest opinions.
On its way out: Celebrity hairstylist Andrew Fitzsimons says that in 2019, he hopes people will be kinder to their strands. "I'd love to see more people embracing their natural textures versus putting their hair through hell trying to achieve a texture that isn't natural," he tells us. "We've seen every iteration from perms to toxic straightening treatments to over-bleaching… Let's take a break and let our follicles breathe."
What to try instead: "There are so many amazing styling products out on the market now. Play around with some new brands and products to help celebrate your natural texture," he says. Consider investing in curl cremes, wave sprays, and leave-in conditioners to enhance the beauty of your hair as-is.
On its way out: "Instagram is an incredible source of creative inspiration—I'm on it every day saving ideas—but sometimes it's a little overboard," says Fitzsimons. "Things like the glitter hair and glow-in-the-dark hair, which are trends clearly created exclusively for Instagram and not real life, are a bit much."
Celebrity stylist Marc Mena agrees. "I'm over the whole pastel, mermaid, and rainbow hair color trend. It was fun for a little while, but it's costumey and completely damages your hair. I'm all for self-expression, but you can add color to your look by playing with fashion. Damage your wallet, not your hair."
What to try instead: In place of fantastical social media bait, Fitzsimons proposes more elevated, natural styles. "I prefer hair that's done for the real world (and sometimes the red carpet!)," he explains. If you're personally still itching to give glitter or pastel a go, try something more understated (and less damaging) like IGK's Hair Strobing Glitter Spray or tint your hair with Overtone's pastel conditioners.
On its way out: Scrunchies recently saw a resurgence (and we at team Byrdie have definitely hopped on board), but just as quickly as they were ushered back in, Fitzsimons says he'd rather see them take a leave of absence this coming year. "I feel like every few years, we see a bunch of scrunchie marketing pushes, but I think it's safe to leave these in the past."
Another trend that was big in the '90s that stylists can't get on board with is zigzag hairbands, which had a quick moment at Wang S/S 18. "Like most trends, hair accessories are known to have evolved over the years," says celebrity stylist Sarah Potempa. "While some styles manage to resurface, one hair accessory that can become a thing of the past is the zigzag headband."
What to try instead: While Fitzsimons isn't pro-scrunchie for your daytime look in 2019, he doesn't want you to toss them just yet. "I fully endorse a silk scrunchie at bedtime. It keeps your hair out of your face while you sleep without aggressively pulling on your hair," he explains. For daytime, he says there are so many beautiful accessories available now to try in lieu of the fluffy hair fastener. Justine Marjan's collection of rhinestone bobby pins with Kitsch, for example, is a stunning way to dress up any style. Potempa recommends her metal hair cuffs to decorate a bun, pony, half pony, or braid.
On its way out: "I love a natural-looking ombré color, but severe ombrés should be done [with]," says Mena. "The drastic dark roots that fade into [brassy] ends look unfinished and not purposeful."
What to try instead: "Go for a subtler color shift that looks like you were on the beach all summer with sun-kissed ends," he says. Seeing a professional colorist for natural-looking balayage will help you achieve dimension without harsh lines.


text:
Black & Decker BDCIM18N Impact Driver 18V Bare Unit
The Black & Decker BDCIM18N Impact Driver has a durable metal gear casing and delivers up to 155Nm of Torque for effortless driving and removal of screws and bolts. The driver has a compact, lightweight design that makes the drill easy to use over long periods of time. Its anti-slip soft grip provides additional comfort. Spring loaded slide system is durable and prevents dust ingress.
Ideal for driving large bolts/screws without needing a pilot hole, removing rusty/old or damaged screws and driving self tapping screws straight into metal work.
Bare Unit, No Battery or Charger Supplied.
Bit Holder: 6.35mm (1/4in).
No Load Speed: 0-3,000/min.
Max Torque: 155Nm.
UK Delivery
We set ourselves apart with a rapid & reliable service and aim to deliver your goods as quickly as possible. To compliment our first class service, we offer FREE Standard Delivery for most orders over £75. For all other orders there is a delivery charge of £5 unless otherwise specified.
Exceptions for free delivery include heavy or palletised items which may incur an additional charge - this is calculated during checkout.
Some bulkier items (especially those delivered on pallets) may take longer to arrive and the carrier will contact you to arrange a suitable delivery date.
In most cases the standard service on orders received prior to 4:00pm for delivery to addresses in Mainland UK is that the goods will be delivered within two working days (i.e. If you place your order before 4:00pm on Monday your goods should be delivered on Wednesday). Please be aware that this will be extended over bank holidays.
Zarges Ladders will be delivered usually within three working days, direct from Zarges and are NOT available for Next Day Delivery. When placing your order for Zarges products you will contacted by Zarges or arrange delivery.
To ensure a next day delivery to an address in Mainland UK you should select the next day option.
Our Charges
Up to 30kg
- England, Scotland, Wales £5.00
- Scottish Highlands & Northern Ireland £10.00
- Channel Islands £10.00
- Scottish Islands & Isle Of Man £10.00
Pallet & Heavier Goods
- England, Scotland, Wales £POA
- Scottish Highlands & Northern Ireland £POA
- Channel Islands £POA
- Scottish Islands & Isle Of Man £POA
The cost for deliveries outside Mainland UK will be quoted upon receipt of order. We do not deliver to Ireland.
If you change your mind or it's not quite what you were looking for, please return it in its original condition ensuring you include your proof of purchase so we can exchange or refund. This does not affect your statutory rights.
In the first instance, you can notify us of a return by selecting the Return option in the Account Section.
- All items must be in their original packaging and unused. We are unable to accept return of a product which is not in its original, undamaged packaging or shows any evidence of use.
- We can offer to collect at a charge of £12.50 per collection. For heavier items or hazardous items, including all liquids, the collection fee will be priced on application.
- Once we receive your item back at the warehouse, we'll refund you within 5 working days.
In the unlikely event that your item is damaged or is incomplete, please contact us with 24 hours of receipt by mailing us at email@example.com or calling us during office hours on 01869 327123.
Rapid Engineering Supplies Ltd.
c/o WEBSHOP ORDER
Unit B8, Telford Road,
Bicester, OXON OX26 4LD


text:
AY Kids - Lesson 1 - Do Not Hold a Grudge
"I'm sorry, I was embarrassed to tell you I ripped your coat I borrowed and that's what took me so long to return it to you," she said. "I hope you'll forgive me."
Lessons designed specifically with kids in mind!
Ideal for 8-12 year olds with an adult or teen group leader.
"I'm sorry, I was embarrassed to tell you I ripped your coat I borrowed and that's what took me so long to return it to you," she said. "I hope you'll forgive me."
The Case Of The Stolen Bicycle I loved my brand new 10-speed bike, a shiny black Diamondback. I would ride around after school and visit my friends.
The Torah teaches us to not desire someone else's possessions. It says of a person who is envious 'His entire life is pain, and he will never be happy' (Sota 9).
Our Torah tells us that we must not to take revenge, Vayikra 19:18.
When we visit the sick, attend to their needs and daven for their recovery, we fulfill both of the positive mitzvos of V'ahavta L'Rayacha Kamocha - 'Love Your Fellow Jew as You Love Yourself' and Vehalachta Bidrachav - 'You should walk in H
The Torah expects us to give people the benefit of the doubt, Pirkay Avos (1:6).
The Torah tells us, "Do not be a gossipmonger", Vayikra 19:16, and "Do not accept a false report", Sh'mos 23:1.
Hurtful words are called "o'na'as d'varim," and the Torah forbids us from speaking them.
The Torah teaches us that we are not allowed to embarrass another, Lo sonu eesh es a'mi'so - "Do not hurt a fellow Jew" (Vayikra 25:17).
The Torah teaches us to be happy with our lot. This mitzva is found in "The Code of Jewish Law—Shulchan Oruch, Orach Chaim" (230:5) which requires each of us to believe that everything HaShem does is for the very best.
There may be a new one that is full of old wine, and an old flask that doesn't even have new wine in it. We learn from here that we shouldn't just look at the outside of a bottle, rather look deeper at the inside where we might find something valu


text:
Month: June 2016
Tips to Prevent Injury in Young Athletes
First Things First
The best way to determine whether your athlete is ready to tackle a new sport is to invest in a pre-season physical. An experienced medical professional will be most capable of examining your young athlete for pre-existing conditions. They will be able to distinguish minor aches and soreness from serious problems. Thus, this first step is incredibly important.
Don't let your young athlete push through pain. Talk to them to ensure that they are not just being tough, but that they are actually pain-free. If your child does seem to have soreness, an injury, or minor aches and pains frequently, consult a doctor before allowing them to enlist in a sport. Many times, children and teenagers can experience problems like scoliosis without realizing it. These types of conditions should be treated before they worsen from activity.
Staying Hydrated & Healthy is Key
Dehydration is the root of many illnesses, especially for athletes. On those hot summer days or cold winter nights, it is important that your young athlete drinks enough water before, during, and after the game. Fatigue and nausea are common signs of dehydration. If you start to see signs of weakness, pull your athlete out immediately and tend to them with an adequate amount of water before letting them get back in the game.
Hydration is only the start to preventing injury. Overall nutrition is important as well. You want to be sure that your athlete is eating a well-balanced diet everyday. Foods like meat and vegetables (which have protein), nuts (which have fiber), and milk (which has calcium and vitamins) help keep your kids healthy and stronger against injury. Make sure they are eating enough and that they are eating foods with nutritional value. It is also good to try to maintain a healthy eating schedule. If possible, feed your kids meals around the same times every day.
Cross Training Can Help
When your kids play one sport year round, they are putting strain and stress on the same muscles repeatedly. To make sure that different muscles are being used, see if they might be interested in playing more than one sport. Not only will they diversify their skills and make new friends, they will mix up their routine and ensure that certain muscles are not overused.
Stay Ahead of the Game with Blackwatch Sports
Blackwatch Sports is comprised of a dedicated, passionate staff that has competed at the highest levels of athletic performance. Our coaches, instructors, and medical advisory board are here to provide years of nutritional, medical, performance, strength, and conditioning experience to your young athlete and help prevent injury. Learn more from our experts. Contact us today!


text:
What Can Cognitive Science Say or Learn about Economic Crises?
Osman, M., Meder, B., Gigerenzer, G., Chater, N., Read, D., & Neth, H. (2012). What can Cognitive Science say or learn about economic crises? (Symposium). In N. Miyake, D. Peebles, & R. P. Cooper (Eds.), Proceedings of the 34th Annual Meeting of the Cognitive Science Society (pp. 48–49). Austin, TX: Cognitive Science Society.
Abstract: Economic crises bring to the fore deep issues for the economic profession: why are such crises often not foreseen, and what does this entail for economic theory? In this symposium we also adopt a self-critical analysis, by asking the following: what can the cognitive science community say or learn about cognition and behavior in the context of economic crises? After all, cognitive science shares one of its principle objectives with economics: to investigate and model the principles that underlie and govern human behavior.
Keywords: Cognitive Science, Economics, Decision making, Uncertainty, Behavioral Economics, Rationality, Heuristics
Resources: Download PDF | Google Scholar


text:
Around 100 sovereigns of gold jewellery along with diamonds and Rs. 3 lakh in cash have reportedly gone missing from a house belonging to an industrialist in Defence Colony in Nandambakkam.
The house owner, A. Jayaprakash, had filed a complaint with the Nandambakkam police on Friday night stating that he found the jewellery and cash missing after he returned from a trip to Tirupathi.
When he and his family returned from the temple town on Fridaythey found the back door of the house open. Nandambakkam police are investigating.


text:
Latitude: 53.4362 / 53°26'10"N
Longitude: -2.3365 / 2°20'11"W
Nearest Postcode: M33 5GT
OS Eastings: 377741
OS Northings: 393326
OS Grid: SJ777933
Mapcode National: GBR DX3P.YX
Mapcode Global: WH98H.2WNL
The nearest postcode is for approximate location purposes only (eg, sat-nav use), and is not necessarily the correct postal address postcode for this location.
The Street View image is of the nearest location (within 1km) that has imagery available. It isn't necessarily the precise location of this object. It's just there to give a general impression of what the surroundings are.
(Links open in a new window)


text:
Move over Cindy Crawford, there's a new model in town and he's BIG!! This week on IN YO MOUTH, Muñoz and Marie venture to Queens to bring you their first ever crossover episode with international super star, plus size model, and host of the Big Things podcast, Zach Miko! Together they proudly present BIG THINGS IN YO MOUTH! Two years ago, Zach made headlines when he was the first big and tall model to be signed by IMG models brand new Brawn division. Now he's super famous!! And Muñoz and Marie can't believe their luck that they got to spend a morning chowing down on bacon, egg and cheese bagels with the sexy (married) man. From dishing about modeling to body positivity to Instagram influencers to dog farts – these three cover it all! It's an ENORMOUSLY special episode that you don't want to miss! So put on something fancy, grab some wings (Zach's favorite) and tune in today!
Follow Zach on Instagram @ZachMiko
Twitter: @inyomouthpod
Instagram: @inyomouthpod
Email: [email protected]
Podcast: Play in new window | Download


text:
-older agents: streptomycin sulfate, dihydrostreptomycin, kanamycin, and neomycin,
-newer drugs: gentamicin, tobramycin, amikacin, and netilmicin (Matz, 1990)
Cochleotoxic: (ie: more effect on auditory system than vestibular system)
-Dihydrostreptomycin, neomycin, kanamycin, amikacin, sisomycin, livodomycin
Vestibulotoxic: (ie: more effects on vestibular system)
-streptomycin and gentamicin.
Nb: streptomycin selectivity has been used to advantage in the treatment of bilateral active Ménière's disease or to relieve disabling vertigo and preserve hearing in patients with one hearing ear.
Pharmacokinetics and biochemistry
-only 3% of orally administered dose is absorbed from GIT \ give IV.
-tissue concentrations of aminoglycosides are 1/3 of serum concentrations.
-BBB penetration of aminoglycosides is negligible, except in neonates.
-Can cross placenta, \ fetal ear is susceptible to their ototoxic effects.
-excreted almost exclusively by glomerular filtration Þ urinary concentrations may reach levels 10 x' > serum.
\ Impaired renal function reduces rate of excretion Þ accumulation in blood & inner ear toxicity.
Mechanism for inner ear loss due to ototoxic drugs:
a.-recent experiments Þ an ototoxic metabolite may be formed (Huang and Schacht, 1990).
b.-Henley and Schacht (1988) dispute the concept of perilymph accumulation of aminoglycosides.
-aminoglycoside do not accumulate in perilymph
-perilymph concentrations do not correlate with development of toxicity in experimental animals.
-aminoglycosides do not accumulate in inner ear fluids
-They report ratio of gentamicin in inner ear tissues is significantly lower compared to plasma levels.
c.-Williams (1987) biochemical molecular basis of aminoglycoside toxicity:
- a multistep mechanism of toxicity.
i. binding of aminoglycoside to outer plasma cell membrane.
(This binding is reversible and is antagonized by divalent cations calcium and magnesium).
ii. energy-dependent uptake into cell.
iii. inside the cell they interfere with I/C processes (eg synthesis of polyphosphoinositides).
d.-Anniko et al. (1982), ??? membrane phospholipids in coclea serve as aminoglycoside targets.
e.-energy metabolism may be target in aminoglycoside ototoxicity
f.-aminoglycosides may?? reduce transport of glucose into inner ear. (Garcia-Quiroga et al., 1978).
g.-Takada et al. (1983) Þ gentamicin ototoxicity is not related to glucose uptake or utilization.
h.-Kroese and Van den Bercken (1982)
Þ low concentrations of aminoglycosides may have a dual action on sensory hair cells.
(1) to increase spontaneous afferent nerve activity by affecting hair cell membrane
(2) to cause marked impairment of the mechano-electric transduction process.
i.-Takada and Schacht (1982) aminoglycoside ototoxicity occurs in two stages:
i. an initial effect, a membrane effect on phospholipids, (antagonized by calcium ii. second step that is noncompetitive and irreversible.
j.-role of phospholipids as a target for aminoglycoside ototoxicity:
-experiments have shown the presence of a specific phospholipid in isolated outer hair cells.
-genta has selective & high affinity for this phospholip(phosphatidyl inositol4,5,bisphosphat)
k.-Schacht proposed a molecular mechanism of consisting of several sequential stages:
(1)reversible binding of aminoglycoside to plasma memb, which can be antagonized by calcium ;
(2) energy-dependent uptake of aminoglycosides
(3) intracellular binding to phosphatidylinositol 4,5,-bisphosphate, preventing its hydrolysis and
preventing subsequent formation of the second messenger inositol trisphosphate and the
activation of protein kinase C.
Pharmacokinetics and ototoxicity
-half-life of gentamicin elimination from inner ear tissues increases significantly with chronic treatment.
-Ototoxicity is related to"area under the curve," (approximated by peak & trough levels)
-studies on animals Beaubien et al. (1989) Þ no relationship b/w ototoxicity and plasma level.
Rather the total dose or area under the curve was a much better predictor of amikacin ototoxicity.
-ototoxic effect might be ß if interval b/w doses is long enough for clearance from perilymph.
-delayed onset of ototoxicity
Þ ???redistribution of gentamicin into susceptible cells or cellular compartments.
Þ ???recent studies: toxic metabolite of aminoglycosides Þ ototoxicity.
-Delayed ototoxicity: continuing damage to sensory structures of organ of Corti after termination of treatment
-Degeneration of neurons may occur several years after loss of inner and outer hair cells caused by
kanamycin intoxication so that use of a cochlear implant not usable.
-even if cochlear neurons remain in large numbers, their dysfunction and delayed degeneration may limit the potential benefits of cochlear implants.
-high-affinity binding sites for gentamicin in the organ of Corti & vestibular maculae.
-dissociation constants Þ fourfold greater affinity of gentamicin for vestibule than cochlea,
Þ tendency for gentamicin to cause vestibular toxicity > auditory damage.
-No significant difference in binding of gentamicin to tissues in cochlear apex vs base.
nb: there is a predilection for damage to occur in the basal turn initially.
-potential targets for aminoglycosides are:
-enzyme ornithine decarboxylase.(found in kidney and cochlear.........both inhibited by neomycin)
-acidic glycosaminoglycans (
-nb glutathione pathway in the cochlea may also play a protective role against aminoglycoside ototoxicity
-route by which aminoglycosides reach hair cells from bloodstream is not known.
-Animal studieshave shown that:
(1)direct relationship between degree of aminoglycoside ototoxicity and level of drug reached in perilymph
(2)aminoglycosides perfused directly into perilymph space can induce toxic effects.
drug-induced damage to cochlea parts
Þ selective destruction of type I hair cells of crista ampullaris.
Þ type II hair cells are destroyed later,
Þ selective destruction of outer hair cells in the basal turn of cochlea,
-with greatest number of missing outer hair cells noted in first row facing tunnel of Corti
Þ with progression toward apex as the dose and duration of treatment are increased.
Þ supporting cells tend to remain intact.
Þ Some investigators noted apical inner hair cell injury & rarely supporting cells damage.
Þ damage to structures lining cochlear duct, (including spiral ligament, stria vascularis, vestib memb,
spiral prominence, and pericapillary tissues of the outer sulcus.
Þ stereocilia can change into giant hairs, balloon at base, fuse,& (F) intercellular bridges Þ degenerate Þ normal organs of Corti but had a reduction of cochlear ganglion cells (one third < N cochleas)
-raises possibility that the spiral ganglion may be the target for ototoxicity in some patients.
Þ early loss of hair cells in the basal turn of the cochlea.
Þ more severe damage, this loss extends towards the cochlear apex in an orderly fashion:
-first row of outer hair cells is most susceptible,
-followed by middle row of outer hair cells,
-last the outermost row (Lerner and Matz, 1980).
-Only after most of outer hair cells have been destroyed are changes seen in single row of inner hairs.
-inner hair cell damage is most severe in apex and progresses toward the base.
-Next the tunnel rods as well as other supporting cells of organ of Corti are destroyed.
Þ when auditory damage has progressed to the point at which hair cells are killed, there is no recovery b/c they do not regenerate(Brummett et al., 1978).
-Nb: hair cell damage and auditory dysfunction in patients may be asymmetric.
-histologic picture of drug-induced damage to vestibular parts:
-most obvious effect is loss of hair cells in the utricular, saccular macula & crista of the semicircular canals, which, do not regenerate.
- monitored for two reasons:
(1) to ensure adequate levels for therapy, and
(2) to detect elevated or rising levels that may be associated with ototoxicity and nephrotoxicity
-Renal function best index: creatinine clearance,
serum creatinine level is a good indirect estimate of GFR.
-Suggested schedules (Lerner and Matz, 1979):
1. For normal renal function:
-Peak level on first 1 or 2 days of therapy,
-trough determined within 1 week,
-peak-and-trough levels are determined weekly thereafter.
Nb: Peak levels:1 hour after administration
nb: Trough levels: 15 minutes before next dose.
2. For impaired but stable renal function:
-peak-and-trough levels within first 1 or 2 days of therapy.
-Serum levels daily if renal function remains unstable.
Nb: It has never been established conclusively if occasional Ý serum peak-and-trough levels Þ ototoxicity.
-Routine auditory monitoring of pts taking ototoxic drugs is unnecessary unless they are high-risk:
-impaired renal function, pts who have taken aminoglycoside in past, consistent Ý peak/trough levels -pts with past/present vestib/coch loss, pts in whom a vestib/cochl loss may be debilitating, eg pilots.
Clinical Toxicology
-Humans can hear up to 16,000 Hz, (most audiometers only test up to 8000 Hz).
-patient is not aware of hearing loss until it is >30-dB affecting frequencies as low as 3000-4000 Hz.-
Inc: In most prospective studies the incidence of aminoglycoside ototoxicity is about 10%.
Risk factors for ototoxicity ;
-bacteremia, elevated temperature, liver dysfunction, ratio of serum urea nitrogen to serum creatinine
longer duration of therapy, elevated serum peak and/or trough levels, advanced age, concomitant use of
other ototoxic medications, especially the loop diuretics furosemide and ethacrynic acid.
-nb All potential toxicities are most likely to occur in patients with compromised renal function.
-Acute damage to auditory syst is usually heralded by tinnitus (but ototoxic effects can occur without tinnitus).
-Deafness from these drugs initially affects hi frequ's but, as damage progresses, lower frequ are also affected.
-Once ototoxicity has been detected clinically, if aminoglycosides are discontinued, ototoxic effects cease.
At least some initial shifts are reversible.
-Ototoxic effects that present 2-3 wks after stopping A/B's are likely to be permanent (Lerner et al., 1984).
-10% to 15% of patients with aminoglycoside ototoxicity have reversal of the abnormal electronystagmograms and audiograms, thus indicating reversibility of toxicity.
Vertigo is a manifestation of vestibular toxicity.
-Symmetric loss of vestibular fnctn is seen in pts undergoing titrated streptomycin as rx for bilat Meniérè's.
-Some cases, the vestibular effects are reversible although permanent damage usually occurs.
-Rotational vestibular testing Þ initial and most severe vestibular effects to be in lowest frequency range,
with variable extension into higher frequencies.
-nb:Unilateral loss, either of the vestibular or the audiometric system, is possible in aminoglycoside ototoxicity.
Ototopical medications;
-commonly used for bacterial infections are:
neomycin, polymyxin B, and propylene glycol; chloramphenicol
-Morizono (1988) found ototoxic effects in guinea pig from topically used gentamicin eardrops in ME.
-further, propylene glycol (one of the most commonly used carriers of drug otic solutions) is ototoxic.
-ototoxic effect can be reduced in ME if there is profuse ear disease with pus & thick mucosa covering the RW.
-Solut'ns introduced into chronically infected ME of humans are ?? not absorbed into cochlea to significantly. -??due to oblique orientation of the human round window or
-?? due to poor penetration through the chronically infected middle ear mucosa.
\ neomycin and other eardrops should be used with caution in patients with TM perforation.
-Reports of ototoxicity following topical administration of neomycin to large surfaces (eg peritoneal cavities)
-Animal studies Þ cochlear damage by these various preparations (Leach et al., 1990; Morizono, 1988),
but there are anatomic and pathologic differences between the animal model and man.
-Podoshin Þ small (approx 6dB) but statistically significant worsening of hearing in pts treated for (COM)
-concentrated solutions of aminoglycosides (streptomycin, gentamicin) are introduced into ME cavities of pts
with Ménière's disease to unilaterally ablate peripheral vestibular function, Þ significant cochlear ototoxicity -use of otic preparations, esp with TM perforations, should be carefully monitored.
-Cochlear toxicity has been reportd foll top applicat'n of neomycin eardrops to RW memb in guinea pigs.
-Hair cell damage similar to that seen after IV administration of neomycin in guinea pigs has been noted.
-eardrops containing neomycin in humans does not appear to be associated with a high risk of ototoxicity.
-Marsh and Tom (1989), five antimycotic ear-drop preparations were studied.
-25% m-cresyl acetate,
-2% acetic acid,
-1% clotrimazole, and
-1% tolnaftate.
-All the agents studied were clearly ototoxic in guinea pigs.
-can Þ bilaterally symmetric SNHL, which may be sudden in onset (Arnold '81; Matz, 1990; Schuknt, 1974).
Pharmacokinetics and biochemistry
-act on the loop of Henle to inhibit the reabsorption of Na, K, & Cl ions by a Na-K-2Cl carrier (Greger, 1985).
-most cases of loop-diuretic ototoxicity are temporary and fully reversible
-reversing within 30 minutes to 24 hours of administration (Koegel, 1985).
Risk factors: renal failure, rapid rate of administration, and concomitant aminoglycoside administration
-excreted in the urine.
-half-life for renal elimination of 291 minutes (
-elimination decreases greatly in patients with advanced renal failure.
-plasma half-life is ~ 45 to 92 min in (N) but is prolonged to ~3 hours in pts with renal failure.
-gastrointestinal uptake is high; ( ~65% of an oral dose of furosemide is absorbed)
-Plasma levels > 50 mg/L frequently Þ hearing disturbances.
Biochemical mechanisms of the ototoxic effects of loop diuretics:
-not been fully characterized.
-furosemide is a potent inhibitor of adenylate cyclase isolated from stria,
but not Na-K ATPase at concentrations that inhibit the endocochlear potential.
-loop diuretics influence ion pumps in kidney and cochlear duct.
-loop diuretics block the system that transports potassium chloride out of marginal cells of stria vascularis. This would explain the shrinkage of marginal cell, which may lose water if ions continue to move into the endolymph from it.
-an organic acid transport uptake mechanism may play a role in ototoxicity of furosemide.
-furosemide has been shown to alter active processes in cochlea, Þ reversible alteration of basilar
membrane responses to acoustic stimuli (Ruggero and Rich, 1991).
Best avoided by:
-slow rate by intravenous infusion (less than 15 mg/min) (Matz, 1990),
-decreasing the dosage in the presence of renal failure,
-avoiding the concomitant use of aminoglycosides (Koegel, 1985).
Nb: Once ototoxicity from these agents is established, the only management is drug cessation.
-inner and outer hair cells of animals treated with high doses of furosemide did not show any damage.
-edema & cystic degeneration of stria vascularis has been noted in animals injected with ototoxic doses of both loop diuretics.
-No changes were observed in the cochlear nerve fibers or ganglion cells.
-furosemide Þ stereocilia of outer row of outer hair cells in guinea pig may be splayed.
Þ tip links b/w adjacent stereocilia of outer hair cells may be stretched/broken.
Pharmacokinetics and biochemistry
-Orally: absorbed very rapidly in gastrointestinal tract
-half-life of 6 to 15 minutes.
-Absorption is influenced by gastric emptying time and presence of food in stomach.
-Aspirin is hydrolyzed in body to salicylic acid.
-Once absorbed from the serum, salicylates are distributed mainly to the EC water compartments.
-Concentrations of salicylts are higher in liver&kidney VS serum, whereas brain concentn's are 10% of serum
-quickly enter perilymph after systemic administration.
-perilymph concentration after systemic administration is fourth to one third of blood level.
-concentration in perilymph reaches maximal value ~ 2 hrs after intraperitl injection in animals.
-Other study: relationship between serum and perilymph salicylate level was nearly linear.
-excreted mainly in the urine.
-Chinchillas receiving 450 mg/kg IP Þ Ý evoked response threshold of 30 dB, (esp at hi frequencies)
-Guinea pigs receiving salicylates at (450 mg/kg IP) Þ Ý spontaneous activity of neurons in inferior colliculus.
-Humans, serum salicylate concentrations of 20-50 mg/dL Þ hearing losses of up to 30 dB.
-Linear relationship between hearing loss and unbound salicylate concentrations (Day et al., 1989).
-or even below 20 mg/dL...(Day 89).
-salicylate concentrations of 11 mg/dL Þ hearing loss at any given frequency was 12 dB.
-tritium-labeled salicylate is detected quickly in blood vessels of stria vascularis & spiral ligament (Ishii 1967). -Within an hour label was found in:
-outer tunnel of organ of Corti
-around outer hair cells
-Rosenthal's canal around the spiral ganglion cells.
Pathog: (NB:most of below are animal studies)
-Salicylates suppress the AP at low but not at high sound intensities
suppress cochlear microphonics (but no effect on summating potential...Puel, 1990).
-??? prostaglandin.......Escoubet et al. (1985) & Jung et al. (1988a):
-controversy whether salicylate effects on cochlea are mediated by prostaglandin metabol..
-??? leukotrienes..... Jung et al. (1991):
-topical application of leukotrienes to RW membrane of chinchilla Þ HL..
-???? inhibition of transaminase and dehydrogenase systems ....Silverstein et al. (1967).
-sodium salicylate selectively reduces (CN VIII) action potential in experimental animals Mitchell (1973).
-??? cochlear blood flow:
-effect of salicylates on cochlear blood flow has been proposed....Hawkins (1973) (Malotte et al., 1990)
-vasoconstriction in capillaries of suprastrial spiral ligament, stria vascularis, tympanic lip & basi memb. but not sufficient to cause loss of sensory cells or changes in the stria vascularis.
Human studies
-no significant cellular alterations were found at the light-microscopic level.
-the site-of-lesion testing of the auditory system in patients suffering from salicylate-induced hearing loss suggests a cochlear pattern (McCabe and Day, 1965),
-histopathologic studies as yet have not pinpointed which cells are altered.
Pharmacokinetics and biochemistry
-Renal excretion by glomerular filtration.
-There is extensive and strong binding of cisplatin to serum proteins, and this cisplatin-protein complex is inactive against tumor cells.
-not known whether toxic metabolites of cisplatin are formed in inner ear oroutside.
Animal studies:
-cisplatin inhibits the activity of adenylate cyclase in the cochlear tissues.....Bagger-Sjöbäck et al. (1980)
-chinchillas: eightfold increase in prostaglandin levels in perilymph (Jung et al., 1988b).
-tendency for cisplatin to damage outer hair cells.
by initially blocking outer hair cell transduction channels (McAlpine and Johnstone, 1990) causing a reduction in hair cell receptor current and subsequent hearing loss.
-outer hair cells of the basal turn of the cochlea are damaged first, with damage to the more apical cells occurring when the dosage is continued (Fleischman et al., 1975; Stadnicki et al., 1975).
-first row of outer hair cells appears to suffer the greatest damage (Estrem et al., 1981; Moroso and Blair, 1983; Nakai et al., 1982, Schweitzer, 1984, 1986b).
-irregularity of surfaces of stereocilia of both inner and outer hair cells was noted, (esp in apical turns).
-stria vascularis damage only by high dose intravenous cisplatin.
-cisplatin ototoxicity is enhanced by aminoglycosides (Schweitzer and Olson, 1984),
by loop diuretics (Brummett, 1981; Komune and Snow, 1981; McAlpine and Johnstone, 1990), by aminooxyacetic acid (McAlpine and Johnstone, 1990), and by exposure to moderate or high levels of noise (85 to 100 dB SPL in chinchilla) (Boettcher et al., 1989a; Gratton et al., 1990).
-Symptoms that strongly suggest cisplatin ototoxicity: otalgia, tinnitus, subjective HL (Reddel et al., 1982). -Tinnitus in 2% to 36% of patients receiving cisplatin (Moroso and Blair, 1983)
-often transient, lasting from few hours to a week after cisplatin therapy (DeConti et al., 1973).
-Hearing loss:
-incidence in patients treated with cisplatin is b/w 9% (Higby 1974) & 91% (Helson 1978).
-usually bilateral and appears first at high frequencies (6000 and 8000 Hz)
-may experience some degree of reversibility, but when HL is profound, Þ permanent (Hayes 1977). -it may not be detected without audiometry.
-ototoxic critical cumulative dose of cisplatin is 3 to 4 mg/kg body weight
-worse by bolus injection.
-may be minimized by slow infusion and dividing the doses over several months.
-Vestibulotoxicity is especially likely to occur in pts with pre-existing abnormalities of vestibular function.
Nitrogen mustard....(Mechlorethamine)
-massive doses of nitrogen mustard (0.6 to 1.5 mg/kg) Þ mod to severe bilateral SNHL in most patients -generally permanent.
-Histopath in human Þ shrinkage of the organ of Corti without hair cell loss.
-an iron-chelating agent
-high-dose Þ acute onset SNHL, often associated with acute onset visual loss (Olivieri et al., 1986).
-mostly involves high frequencies, and usually is permanent (Gallant et al., 1987).
-Mintz 1973 Þ first clinical case of hearing loss related to erythromycin.
-Hi risk pts are elderly individuals with hepatic or renal failure or those with legionnaires' disease.
-Symptoms of ototoxicity include subjective hearing loss, "blowing" tinnitus, and occasionally, vertigo.
-Current recommendations, dose of erythromycin does not need to be altered in renal failure (Bennett 1980).
-hearing loss is usually reversible.
-Schweitzer &Olson 1984; (guidelines for prevention of erythromycin-induced ototoxicity:
1. daily dose should not >1.5 g if creatinine is > 180 mol/L.
2. Pre&post-treatment audiograms (esp in elderly and renal or hepatic insufficiency).
3. Caution in patients already receiving ototoxic drugs, such as furosemide, cisplatin, or an aminoglycoside
Pharmacokinetics and biochemistry
-nephrotoxic and ototoxic.
-It is important to specify from which phase of the pharmacokinetics curve a blood sample is obtained before meaningful statements that relate blood levels with toxicity can be made (Banner/Ray, 1984).
-Infusion rate can drastically affect "peak" concentrations (Banner and Ray, 1984).
-Elderly patients, (even with normal renal function), have reduced total systemic & renal clearance.
-In premature infants, vancomycin has a significantly longer half-life and volume of distribution.
-vancomycin given during 2nd &2rd trimester of pregnancy does not cause transplacental sensorineural hearing loss or nephrotoxicity in the fetus (Reyes et al., 1989).
-Hearing loss in humans occurs at blood levels of vancomycin >30-45 mg/L (Snavely and Hodges, 1984).
-Vancomycin to guinea pigs in near-lethal doses was found to be nonototoxic (Brummett et al., 1990). Therefore, Þ appears to have a very small probability of causing ototoxicity.
-Increased incidence of ototoxicity & nephrotoxicity has been observed in humans and animals receiving vancomycin and aminoglycosides in combination (Rybak and Boike, 1983).
-Positional nystagmus, previously reported as a sign of ototoxicity, is a sensitive sign of toxicity.
-all patients can be questioned regarding auditory and vestibular symptoms on daily records.
-whenever possible, baseline audiometric and vestibular testing should be obtained.
-In several special patient populations, periodic testing during treatment is advisable.
1. Patients with impaired renal function
2. Patients with elevated peak-and-trough serum levels of ototoxic drugs.
3. Patients with pre-existing SNHL, especially those resulting from ototoxic drugs.
4. Patients taking more than one ototoxic drug or those with a previous history of using ototoxic drugs.
5. Patients for whom a treatment course in excess of 14 days is planned.
6. Patients with symptoms suggestive of cochlear/vestibular toxicity that become evident during treatment.
7. Patients over the age of 65.
8. Patients taking any combination of an aminoglycoside antibiotic and a loop diuretic such.
Cummings, C. Otolaryngology. chapter 165
Gates Current Therapeutics
Scott Brown, , Otolaryngology
Schucknect, Pathology of the Ear


text:
I'm a computer scientist using machine learning to approach problems in biology and healthcare.
Currently a PhD student at Stanford and a product manager at Butterfly Network.
My experience as a software engineer, data scientist, and product manager helps me reframe complex problems in other fields as computational challenges, solve them, then translate the results back to the problem domain.
My research applies machine learning to immunology, genetics, experimental design, and high-dimensional optimization. Recently I've worked as a product manager and software engineer at a unicorn medical technology startup, diving into the world of medical imaging to build a completely new type of ultrasound machine.
Previously, I worked as a data scientist and software engineer at one of the nation's largest hospitals. Before focusing on healthcare, I interned as a data scientist at the New York Times and as a software engineer at Google Nest. I did my undergrad at Princeton, graduating at age 19.
As a full-stack software engineer, I'm recognized as one of the top 2% of users (by reputation points) and as a moderator of the Stack Overflow programming network. As a data scientist, I'm skilled at integrating prediction into the day-to-day business and making the output of predictive models interpretable to decision makers. As a product manager, I excel at diving into green field problems and at enabling teams to accomplish unreasonable things, having led teams of dozens of engineers to ship and grow products to tens of thousands of users.
In my free time, I play music — mostly jazz piano, these days. I love to travel and read.
Please get in touch. I live in the Bay Area and would love to meet.
I was the product manager holistically responsible for Butterfly's mobile ultrasound imaging software — determining what we build and how we build it. I reported directly to the head of product.
Butterfly iQ is the world's first whole-body imager. iQ fits in your pocket, connects to your iPhone, and lets you see inside the body, for $2000 — a fraction of the price of a traditional ultrasound machine.
Butterfly's mission is to make medical imaging more accessible, affordable, and intuitive. In the US, ultrasound is becoming a pillar of the physical examination. As for abroad, two thirds of the world has no access to even basic medical imaging. Handheld, simple-to-use ultrasound at a $2000 price point can help.
What makes Butterfly unique is that the piezoelectric crystals typically used in ultrasound have been replaced by custom-designed semiconductor chips, controlled entirely in software. Rather than swapping ultrasound probes to scan different parts of the body, a clinician scans with a single iQ probe and simply adjusts the scanning preset on their iPhone.
iQ is a medical device with the paradigms that make an iPhone app, an iPhone app. Connect your iQ and immediately start scanning. Swipe on the screen to adjust your image. Easily save to cloud storage and share with colleagues.
I was responsible for Butterfly's iPhone and iPad software, which programs the iQ device, reconstructs images from ultrasound data, uploads captured images and videos to Butterfly secure cloud storage, and enables sharing and commenting for groups of physicians.
I managed the iQ software product from several months before launch to approximately one year after launch. I shipped:
We won an Apple Design Award ("the Oscars of app development"), the SXSW Best In Show and Best in Health, Med, and Biotech awards, and other awards during my tenure.
Butterfly iQ was featured above the fold on the cover of the International New York Times, on the cover of the Science Times, and elsewhere.
I was also responsible for our software testing and release process along with my engineering partners, as we maintained a high-velocity release cadence, rare in medical devices.
Before I managed the core iQ product, my first assignment at Butterfly was to conceive of and build a way to empower non-ultrasound-trained clinicians with ultrasound insights for the first time, using telemedicine.
As a software engineer and product manager, I specced and built Butterfly Tele-Guidance, a green-field project combining ultrasound imaging with streaming video, computer vision, and augmented reality.
Imagine if any medical professional could unlock answers with ultrasound. Our technology emulates the feeling of an expert over your shoulder, guiding your hand as you scan. See press and footage from CES 2019.
Ultrasound is a game of millimeters. With Tele-Guidance, a novice scanner wouldn't need careful training to understand expert ultrasound terminology for maneuvering the probe. Instead, Tele-Guidance tracks the iQ probe's position in the novice scanner's iPhone camera feed. The remote expert can command precise adjustments in augmented reality, leading the novice scanner to the right image and insight.
Within my first 10 weeks, I built a fully functional iOS and web prototype to showcase at a national ultrasound trade show. Then I progressively refined the product through methodical user testing.
I worked as a solo engineer and product manager, with the help of a part-time product manager, pointers from several ultrasound software designers and engineers across the company, and guidance from the head of product and the chief medical officer.
Notable technologies used: Python, Typescript, React, WebRTC, Swift, SceneKit, Three.js, ArUco.
I ran the process to hire and onboard a tech lead to take over my day-to-day responsibilities, before I moved on to the core Butterfly iQ product.
I'm fascinated by immunology and novel therapeutics to treat cancer and autoimmune diseases. My research goal is to reframe biology questions as computational problems, address them using statistics and machine learning, and translate those results into medical insight and treatments.
RNA sequencing mixture deconvolution tool for quantifying immune infiltration: infino — first author.
Cancer researchers are investigating why only a fraction of patients benefit from the new wave of cancer immunotherapies. They believe the composition of the environment around a tumor — especially which immune cells live in the region — may play a role.
But figuring out what's in the "tumor microenvironment" is slow and expensive. Traditional methods (immunohistochemistry, flow cytometry, or mass cytometry) only measure up to a few dozen "markers" at a time — limiting the number of immune cell types identified.
To get a clearer picture, we can actually guess the abundances of different immune cell types. First, you'd measure overall gene expression in a messy mixture extracted from the microenvironment. Then you could computationally deconvolve that mixture into estimates of which components created that mixture. However, my analyses suggest that existing techniques have some notable shortcomings.
Some methods dial in on marker genes with such strict criteria that the biological function of the genes does not turn out to be related to the cell types they're supposed to identify. Others simply struggle to separate challenging mixtures containing cells of similar types, while reporting high confidence in their mistaken estimates.
A key fundamental problem seems to be that existing methods separate mixtures straight into their most granular subcomponents. These state of the art methods jump straight to estimating the abundances of very precise cell types that are actually so similar to each other.
In a messy mixture, that's difficult to get right. And after this risky jump to the most granular level of estimates, these methods don't provide a way to "roll up" those guesses into broader cell type categories, which could be informative even when it's challenging to make a determination at a finer level.
With Professor Jeff Hammerbacher and colleagues at the Icahn Institute at Mount Sinai, I developed a Bayesian hierarchical mixture deconvolution method tailored to the kind of RNA-seq gene expression data you would measure in the tumor microenvironment.
Here's the idea: to make better estimates of what's in a gene expression mixture, first we find and leverage the similarities between the gene expression profiles of different cell types. This approach forms a "hierarchy" of immune cell types.
We can understand the uncertainty of our predictions at every level of granularity in this hierarchical tree. In a real-world sample of all sorts of cells in a tumor microenvironment, our method might be too uncertain to separate a mixture into precise individual cell types, but confident enough to give an accurate answer at a higher level of abstraction — such as separating only into B cells, CD4 T cells, and CD8 T cells. A user can interrogate complex mixtures at increasingly fine levels of granularity to an acceptable level of uncertainty in the prediction.
We processed and analyzed genomic data to motivate and implement this new hierarchical approach. Once we learn the similarities between cell types from the data, our generative model simulates how these subcomponents could be added together to produce the mixtures in question. Our proof of concept produced significantly more accurate estimates of immune cell types in challenging mixtures.
Using the Cancer Genome Atlas clinical dataset, we're assessing the association between immune cell infiltration into the tumor microenvironment and a patient's response to immunotherapy. The results could shed light on a key mystery that prevents broader benefit from new cancer therapies.
My colleagues and I presented the work at a UPenn symposium in May 2017, at the International Cancer Immunotherapy Conference in Germany in September 2017, and at the Society for Immunotherapy of Cancer meeting in D.C. in November 2017. [Preprint, Code]
Tens of thousands of Princeton students rely on ReCal, the app that helps you create a schedule from the hundreds of courses offered every semester. I built and launched ReCal with two classmates.
Then we started a university-sponsored incubator to empower student developers with launch assistance, funding, and long-term maintenance.
A friend and I ran the 2014 Princeton Silicon Valley TigerTrek, the trip that brings 20 undergrads to Silicon Valley for a week of off-the-record Q&A with the legends of the Valley. We met with Peter Thiel, Meg Whitman, John Doerr, Sal Khan, and others. Now in its 9th year at Princeton, the trip community is steadily growing.
Sift is a git-inspired personal search utility that gives you full text search over hard-to-search files like Word, LaTeX, and PDFs. Sift also lets you fully index directories before you offload them to long-term cloud storage. Written to be portable and easily extensible to new file types.
Legato Network is my piano tracking and sharing project for helping traveling musicians find pianos to play on.
Every year or two, I write an update letter to stay in touch with old friends and mentors. I post them here because they're a chronicle of what I'm working on and thinking about now:
Finally, a clip from a recent jazz concert (I'm on piano):


text:
Save a doctor and build your
medical team Doctor is saved to your
medical team Saving a doctor is currently down.
Please try again later.
medical team Doctor is saved to your
medical team Saving a doctor is currently down.
Please try again later.
Dr. Nancy Fung, MD
Physical Medicine & Rehabilitation
1450 Chapel St New Haven , CT 06511
Get to Know Dr. Nancy Fung, MD
Accepting Patients
31 Years
- North Shore University Hospital 1999
- Shanghai Second Medical University 1989
Insurances Carriers Accepted
Always check with your healthcare provider for most up to date information
- Aetna
- Humana
Dr. Nancy Fung, MD's Experience
Physical Medicine & Rehabilitation
Board Certifications
- Physical Medicine & Rehabilitation American Board of Medical Specialties
Conditions Treated
- Ankylosing Spondylitis
- Arthritis
- Arthritis of the Elbow
- Ataxia
- Autoimmune Diseases
- Back Pain
- Benign Chronic Pain Syndrome
- Bone Disorders
- Brain Disorders
- Cancer Pain
- Cerebral Palsy
- Cervical Spine Myelopathy
- Chronic Neck Pain
- Chronic Pain
- Degenerative Disc Disease
- Elbow Injuries
- Enthesopathy of Hip (incl. Trochanteric Bursitis)
- Foot Conditions
- Fracture
- Gait Abnormality
- Intervertebral Disc Disease
- Knee Disorders
- Low Back Pain
- Myelopathy
- Nerve Root Injury and Plexus Disorders (incl. Pinched Nerve)
- Osteoarthritis of Ankle and Foot
- Osteoarthritis of Hip
- Osteoarthritis of Knee
- Osteoarthritis of Shoulder
- Osteoarthritis of Spine
- Patellofemoral Pain Syndrome or Knee Pain
- Peripheral Nerve Disorders
- Radiculopathy (Not Due to Disc Displacement)
- Sciatica (Not Due to Disc Displacement)
- Shoulder Disorders
- Spinal Muscular Atrophy (SMA)
- Spine Disorders
- Spondylitis
- Spondylosis
- Sprains and Strains (incl. Muscle Tear)
- Sternum Fracture
- Upper Back Pain
Awards and Recognitions
- Recognized Doctor
Dr. Nancy Fung, MD's Locations
1450 Chapel St, New Haven, CT 06511
(203) 789-3874 Fax: (203) 789-3222
375 Laguna Honda Blvd # B-200, San Francisco, CA 94116
(415) 759-2388 Fax: (415) 504-8322
Notice: "Find a Doctor" is provided by Dignity Health as a convenience to you. The information on each participating doctor is submitted to Dignity Health by each doctor and is not independently verified by Dignity Health. Each doctor is solely responsible for the completeness and accuracy of the information listed about him or her. Dignity Health is not responsible for any loss or damages caused by your reliance on the doctor information contained on Find a Doctor. You should telephone the doctor's office in advance to verify the accuracy of the information.


text:
When an accident victim files a Maryland personal injury case, the plaintiff must present some evidence of the injuries they sustained to satisfy the "damages" element of their claim. If a plaintiff cannot prove that they sustained damages, the court will dismiss the plaintiff's claim, even if the defendant admits that they were negligent in causing the accident.
Typically, a plaintiff will present evidence from either a treating physician or a physician who was seen for the specific purpose of obtaining a medical opinion for the case. Of course, the defendant may be skeptical about the plaintiff's claimed injuries, and they may seek to obtain an independent medical examination (IME) of the plaintiff. Like it or not, if the court orders an IME, a plaintiff must attend and cooperate with the examination. A recent case illustrates the consequences a plaintiff may face if he or she fails to cooperate with a court-ordered IME.
According to the court's opinion, the plaintiff, a railroad worker, was injured when he slipped after stepping in a puddle of oil. The plaintiff filed a personal injury lawsuit against his employer under the Federal Employer's Liability Act and was deposed shortly afterward. The defendant requested an IME, which the plaintiff contested, arguing that it was scheduled too far from his home. The court ordered the plaintiff to attend the IME, but it required the defendant to pay for the plaintiff's mileage.


text:
Commercial Meat Rabbit Cages for Sale
HighTop is a professional meat rabbit cage manufacturer and supplier, our commercial meat rabbit cage can help meat rabbit breeders improve their centralized management and meat rabbit production. We can offer 2 story rabbit cage and 3 tier rabbit cage for commercial rabbit meat production.
Why Choose Raising Meat Rabbit?
- Rabbit meat has high protein content, including eight essential amino acids that the human body cannot synthesize, especially high lysine content.
- Rabbit meat has less fat and low cholesterol.
- Rabbit meat is rich in vitamin B, especially niacin.
- Rabbit meat is rich in minerals, especially calcium.
- Rabbit meat is highly nutritious and low in calories.
Why Choose Commercial Meat Rabbit Cages?
- Commercial meat rabbit cages can save your floor space.
- Improve management efficiency
- Improve the meat production.
How Long is Your Meat Rabbit Cage Service Life?
Our commercial meat rabbit cages use quality steel wire made from low carbon steel Q235, and surface treatment is electro or hot dip galvanized, which is strong and durable, the survice life can be up to 7-10 years for electric galvanized, and 15-20 years for hot-dip galvanized.
Two Types of Rabbit Cage
Cage for Growth Period Rabbit
- Capacity: 3 tier, 18 nests, 18 rabbits.
- Installation size: 1.8m (L) x 0.5m (W) x 1.65m (H).
- Cage size of one line: 1.8m (L) x 0.5m (W) x 0.45m (H) for front, 0.2m (H) for back, including 6 nests.
- Nest size: 0.3m (L) x 0.5m (W) x 0.45m (H) for front, 0.2m (H) for back.
- Big slope making the manure easily roll down, and easy to clean.
- Keep the baby rabbit to 2.5 – 3kg.
Rabbit Breeding Cages
- Installation size: 1.4m long, 0.5m wide, 1.65m high.
- Cage size/strip: 1.4m (L) x 0.5m (W) x 0.45m (H) front x 0.25m (H) back, 2 nests.
- Nest size: 0.7m (L) x 0.5m (W) x 0.45 (H) front x 0.25m (H) back.
- Floor is bamboo board
- Big slope making the manure easily roll down, easy to clean.
- Keep the 2.5-3kg rabbit to 7.5kg as parent.
- The cage can hold the box for giving birth to baby rabbit.
Commercial Rabbit Cage Accessories
The accessories for our commercial rabbit cages including water tanks, pipes and drinkers, feeders, manure board and other rabbit cage accessories.


text:
BEIJING - Pakistan's Ambassador to China, Masood Khan has said that the momentum between China and Pakistan relations is very strong.
During an interview with China's biggest web portal, china.org.cn, the Ambassador said both the countries need to maintain this momentum and work harder to take their relationship to new heights.
He said economic cooperation, cultural exchanges and particularly the relations between the people of the two countries should be enhanced.
He said in the past few years, the two sides have maintained vigorous high-level political dialogue.
He said the newly elected Prime Minister Raja Pervaiz Ashraf, will visit China later this month to attend the World Economic Forum New Champions meeting taking place in Tianjin. But this visit is also very important because he will be able to meet the Chinese leadership and further strengthen bilateral ties, he added. Ambassador said that towards China there is continuity in Pakistan's foreign policy.
The new Prime Minister will build on the strong foundation we have, to consolidate what we have already achieved and to help move this relationship to new heights, he added.
China became Pakistan's largest trading partner in 2011, he said. Pakistan is currently China's second largest trade partner in South Asia. Both the countries have set a goal for US$15 billion in bilateral trade by 2015, he added.
He said that both sides are working to fully utilise their free trade agreements on goods, investment and services they signed between 2006 and 2009.
"We have requested the Chinese government and private sector to help us strengthen our capacity in processing and manufacturing, textiles, leather products, garments, and also in the light engineering sector," he added.
The Ambassador said that Karakoram Highway is being upgraded and plans are being considered to explore a rail link between Khunjerab and Havelian and to establish a fiber link. Asked about the recent strain in the Pakistan-US relations following attack on a Pakistani border post by US/NATO troops, he said our bilateral relations are back on track ,adding, that engagement is now taking place at all levels.
He maintained that Pakistan and the US have had a long history of close relations, despite ups and downs.
"It is important that Pakistan's sovereignty, territorial integrity and independence are respected. Best inter-State relations are based on the principles of mutual respect, mutual trust and mutual benefit," he said.
Turning to Afghanistan, he said that Pakistan supports Afghanistan's efforts to create conditions of peace, stability and prosperity.
He said Pakistan has been contributing to the economic reconstruction of Afghanistan.
He said the war against terrorism has caused devastation in Afghanistan and in the bordering Pak territory. International community's help in the reconstruction of these areas is very important, he said.
China is already playing a very constructive role by investing in Afghanistan and Pakistan, he added.
He said that Pakistan, Afghanistan, and other countries, particularly Afghanistan's neighbours, should work together to fight terrorism.


text:
Enjoy! … and you can leave a comment or send me by email of what do you want to see in the next pack!
For contacts and more information:
Steam – https://steamcommunity.com/id/u_crazyclown/
ArtStation – https://www.artstation.com/anotherluckyguy
Sketchfab – https://sketchfab.com/AnotherLuckyGuy/collections/
Site – https://quicksavant.blogspot.com/
|Game Dev Central Exclusive?
|Product Image
|Media Type(s)
|Read Me, Usage Instructions, Static / Skeletal Meshes, Textures / Materials
|Included File Types
|.fbx, .jpg, .uasset
|Product Category
|2D Assets, 3D Assets, Blueprints, CryEngine, Environments, Game Engine, Games, Materials, Props, Textures, Unity, Unreal Engine
|Product Tags
|Blueprints, Free, pack, PBR


text:
After getting married and having children, all while juggling a demanding job that was becoming less and less rewarding, I found myself very unhappy. I felt I should know what to do – all my life I had known what to do – but this time I just didn't. Then thankfully I found Fiona.
I remember feeling so much relief after our first session. Finally, I felt like someone understood what I was going through. And better still, Fiona had the objectivity and skill to help me find my way out of it all.
My sessions with Fiona have become a regular part of my life. The nature of our discussions has changed over the years, but the dedicated time spent reflecting on aspects of my life, and the insight and clarity I get from my sessions with Fiona, is still invaluable. I can't thank her enough for the impact she has had on myself and my family.


text:
3832 Dempster
Skokie IL
(847) 673-0100
Monday thru Saturday 10:30 AM - 8:00
Sunday 11 AM - 8:00 PM
Poochie's puts
together one of the most attractive hot dogs I've seen.
And they char-grill up one great cheeseburger. Two
out of four ain't all that bad. The fries were
stale and hard. Way too long under the heat light.
And the person at the counter, let's just say, not all
that welcoming. Maybe it was a bad day. I'm
hoping, because their dogs and burgers are outstanding.
July 2004


text:
We take care of our customers not only during the design or manufacturing, but also all throughout our product exploitation.
Our specialists will help you choose the most fitting solution – they will provide you will all of the relevant information in a simple and easy-to-understand manner.More
Once you've placed your order for windows, doors or sliding systems with us, we'll do all of the design work free of charge. Our technical consultants will accurately measure the openings meant for our products and will help you choose the best materials and structural parts for them.More
LURITZ specialists ensure that structures are delivered and installed quickly and professionally.More
LURITZ provides 5-year warranty for its products and mounting works. A 2-year manufacturer's warranty is provided for the fittings.More
By giving our customers unlimited freedom in choosing dimensions and shapes, we focus on quality. Customised products made of top-quality wood preserve their exceptional features, because of which customers choose products of LURITZ.More
Information will be available soon.


text:
"- – – – & – – – – -, Come out to play!"
April 7, 2011
Can you fill in the missing words in the title?
If not, turn up at Arnold Circus in the afternoon of Tuesday April 12th and Tuesday April 19th, and you'll get the picture.
Or just click on this link and the picture will tell you the story –
Tuesday holiday sessions April 2011
And this might give you a clue…..
One Comment leave one →


text:
BuriedTown kept me up until 4am. True story. It's creepy, atmospheric and addictive. A word of warning; you will die several times and go backRead more
Infectonator: Unleash the Zombie Plague
Infectonator – the music will grab you, and dare I say it – infectonate you! The characters are cutesy, the graphics are retro and infectingRead more


text:
Wherever u are..
When u truly wan to hv something
from him..
Pray for him..
He will give you
nt today nor tmrw..
U will hv wad u wan..
someday in ur life..
When u sad..
He might be the only one who always
be with you
Juz u don noe that he is beside you..
he care bout you..
he wan you to always be together with him..
he create this world and all of us..
Do we appreciate him?
Love him?
Remember Him?
EXAM days only two days left...
Engine started...
Took the key..
Opened my car and started the engine
studying mood on~ although quite weird to study in the time like this..but i went to shopping juz now. Cant blame me for this><
Well, they said study in the middle nite is very nice..then tonite i gonna to try it.
In order to watch the meteor rain. Parents went to sleep ler, leave me alone =D
Gonna lock myself to ROOM for next week..Haiz, don like exam either..
PAck my mood up and hv a nice blogging first^^
Today school was as usual, hv some decorating to class 2D1 and hv a nice school day because today was free!(i mean nt need study lar, juz do our revision). Enjoyed this morning a lot..maybe today was the last day for us to play..haiz >=<"
Well, water GAME again today and the one who kena water is me!! -.-''' soi nia..
Omg!! its 11pm now..i gonna go to study ler^^hehe
A very lame post i noe
P/s: I will give u that thing on Monday de..promise^^
Okay, tat's all
Goodnite, sweet dreams~
Enjoy ur day~


text:
Spiritual Direction Is an Invitation
What Does Spiritual Direction Look Like?
Who Is a Spiritual Director?
How Do I Begin Spiritual Direction?
Gød is inviting you into something deeper. Spiritual direction is the space of prayerful, reflective stillness where we notice those invitations—made personally to you in the place where you are today—and how you might respond. We do this through conversation, through listening and sometimes through periods of silence, to allow the Holy Spirit to emerge as the one sets the direction of your personal, spiritual growth.
Spiritual direction carries three main convictions:
1. God is already at work.
Long before the spiritual direction process begins, Gød's always been at work—even if you've never stepped inside a church, even if after 60 years Gød seems to have vanished. The goal of spiritual direction isn't to jumpstart the work of Gød in your life—it's to better notice where Gød is present in the place where you are and how you might nurture it.
2. God is self-communicating.
God is personal. So Gød communicates compassionately with us, speaking into the place where we are, whether we're listening or not. And when Gød communicates, Gød also communicates Gød's very self to be present with us—the way I might give my whole self to you by saying, "I love you."
3. God loves you well and deeply.
Both words are important here. It's one thing to be loved deeply but in ways that don't resonate with who we are. It's one thing to be loved well but in a casual or careful way. But being loved by one well and deeply is to be specially cared for by one who knows you (good, bad and upside down), knows how you're best-loved, and acts on it in every way that's for you.
What Does Spiritual Direction Look Like?
Conversations with a spiritual director usually last about an hour and occur usually about once a month—though that's that the norm, not the rule.
A spiritual director will ask questions. You don't have to have answers. There will be silence, and that's OK; a lot can happen in silence. There may be gentle observations; a spiritual director will help you notice things in the conversation. There won't be very much instruction or advice-giving or, for that matter, levitating. It may simply look like the most intent, focused, one-sided conversation you've ever had with a friend, because that's who your spiritual director is.
Who Is a Spiritual Director?
Spiritual directors are sometimes called a "spiritual friend" or a "soul companion." They're not always priests (though they can be); they're not always wizened old men and women (though they can be); they're not always professionals (though they can be). Whatever they are in fact, they are in spirit laymen, fellow travelers and amateurs in the truest sense (literally, "one who loves"). The spiritual director is invited to come alongside you, lovingly and attentively, to help witness your unique one-on-one relationship with Gød. They're the third wheel; direction is all about you and Gød.
One of the richest metaphors we can use for spiritual direction is that of midwifery. The role of the spiritual director is to support and encourage you, to be your advocate and your coach, through the travail of labor and in the joy of birth. Remember "Gød is already at work"? The spiritual director doesn't initiate the pregnancy; the Holy Spirit does. The spiritual director doesn't deliver the baby; you do. What Gød has begun in you—and even as you read this is developing in you—will come to term on its own, by nature, by design. A spiritual director holds your hand, ensures that you're safe, helps you to push through the breaths, reminds you how well you're doing and stays by your side as long as you need it.
How Do I Begin Spiritual Direction?
Spiritual direction always starts with a conversation. If you're interested in spiritual direction or have questions, just reach out. I'd truly love to hear from you.
At this time, spiritual direction conversations can be set with me locally in Cleveland, Ohio, or distance by video conferencing, Monday through Thursday evenings after 6pm (Eastern) or on weekends.


text:
The European Commission is consulting on draft rules for allocating funds from the EU's emissions trading scheme (ETS) to carbon capture and storage (CCS) and renewable energy projects. Member states will vote on the rules in February.
The commission wants to have the final say on which projects receive ETS funding, according to a draft decision sent to member states last week. This is already the case for projects receiving funds from the European economic recovery package.
Please enter your details
Having trouble signing in?
Contact Customer Support at
or call 020 8267 8120
Not a subscriber?
Take a free trial now to discover the critical insights and updates our coverage offers subscribers.


text:
Practice aerial anywhere with our portable, height-adjustable aerial rigs! Compatible with Aerial Yoga, Aerial Silks, Hoop, Static Trapeze & More.
We have two aerial rigs available, similar in size and shape. They are both high quality, sturdy rigs; both great for aerial hoop, aerial yoga, aerial silks, and static trapeze.
The Height Adjustable Aerial Rig includes top bar connectors, so you can clip your carabiners to it directly, allowing a few extra inches of practice space on Aerial Silks and Hoop. It is also height adjustable. (IN STOCK AND AVAILABLE NOW)
The X-Pole A-Frame includes sandbag covers and is height adjustable but does not have top bar connectors - it is a solid bar. You need either daisy chains or a round sling to choke over the top bar to rig - our Aerial Silks Set and Yoga Hammock Set include the equipment you need for this, you may already have some, or they are available on our website. (CURRENTLY OUT OF STOCK)


text:
(CNN)Elite UK universities Oxford and Cambridge are renowned for stringent admissions policies and student populations weighted in favor of private schools, but one state school has had remarkable success in bucking that trend.
Brampton Manor Academy has revealed that 41 of its students have received offers to study at Oxford or Cambridge, collectively known as Oxbridge, the highest number since its sixth-form college (teaching students in the final two years of high school) opened in 2012.
"We were delighted when last year we sent 20 students to Oxbridge, having seen the number increase gradually from just one offer in 2014," executive principal Dayo Olukoshi said in a press release. "For this to have more than doubled again is phenomenal."
The school is in the London borough of Newham, one of the most deprived in the British capital.
Almost all of the students in question are from ethnic minority backgrounds, according to the press release. Half of them receive free school meals as part of a government program designed to assist disadvantaged families, and two-thirds will become the first in their family to study at university.
State schools in the UK are funded by taxpayer money, and would be called public schools in the United States.
Just 7% of British schoolchildren are educated at independent (a.k.a. private) schools. Yet they still score about 40% of the places on Oxford and Cambridge undergrad programs. These children are generally from wealthy families — private school fees run to tens of thousands of pounds per year — and are primed for an Oxbridge education.
Original article from: https://edition.cnn.com/2019/01/17/uk/brampton-manor-oxbridge-admissions-scli-intl/index.html


text:
For Episode 24 of Heart Lessons I'm so excited to introduce you to Bonnie Nichols of Moms in Prayer International. Moms in Prayer International has a goal that every school in the world would be covered in prayer and I am just so awestruck that the Lord would orchestrate this interview to air just as so many of us around the country are in back-to-school mode and presented with a new school year for our kiddos. I know that Bonnie's words will challenge you to be more intentional about praying for your children and your child's school. But even if you don't have children in school I think Bonnie's passion for prayer will challenge and encourage you to "step up your game" when it comes to your prayer life. She has so many practical tips for building a great habit of prayer and I know you will come away with something great after listening today.
Essential oils, Justin Timberlake, and a for real blast from the past ...
In today's episode of the Heart Lessons Podcast you'll hear from Becky McCoy. Becky is a blogger, writer, and fellow podcaster whose mission is to encourage people to live bravely and authentically in life, especially during life's trials. As you listen to her story you'll find that Becky is certainly qualified to speak to this as she has faced her share of adversity. Becky experienced the loss of her husband Keith to cancer when she was eight months pregnant with their daughter. She talks about what life has been like as she rebuilds her new normal after Keith's passing, what her grief journey has been like, and what is has meant for her to live bravely and authentically. If you are going through a difficult time right now I know Becky's words will be a great source of encouragement for you.
My very special guest on today's episode of Heart Lessons is my son, Micah. A few weeks ago I was listening to one of my favorite podcasts in the car and he piped up from the back, "Mom, can I be a guest on your podcast sometime?" How could I say no to such a sweet request? So today I'm chatting with Micah. We answer the questions you all submitted including what he loves about being a big brother, what he's looking forward to about Kindergarten, and what animal he would like to be. True to podcast form, Micah even shares a heart lesson of his own. I hope you enjoy my conversation with my sweet guy and the additional little sound bytes from my other little cutie.


text:
It used to be that the only people interested in knowing idioms in Tagalog were Filipino or at least living in the Philippines. These days, things have changed considerably. The U.S. State Department reports that there are about four million Americans of Philippine ancestry in the United States. Most of these American speak English as well as their native Filipino dialect, which, in most cases is Tagalog. Learning a few idioms in Tagalog, is as great way to share some fun conversation with a Filipino.
Whether you're trying to connect with co-workers, get along with your fellow students, or find a common thread with your new neighbors, familiarizing yourself with some idioms in Tagalog can break the tension.
Here are some Tagalog idioms to get you started winning hearts and minds in your Filipino community.
These are just a few of the Tagalog idioms. A broader review of many of the most popular Filipino idioms is available here on YourDictionary. If you're interested in further expanding your vocabulary, many of the educational websites such as the Center for Southeast Asian Studies at Northern Illinois University also provide listings of Tagalog idioms.
Unlike the more positive idioms listed above, these are some of the more popular idioms for casting a negative impression about someone:
Insist that you're a magaan ang dugo when you hear these idioms and you might stand a better chance of making it through these slanderous idioms on a positive note.
If you keep an open mind, you'll find that people will meet your slight knowledge of Tagalog idioms with smiles. Everyone finds it charming when a non-native speaker knows a few idioms in their language. It could be the beginning of a beautiful lifelong friendship.
MLA Style
APA Style
By continuing, you agree to our Terms of Use and Privacy Policy.