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The UCMP has one of the best collections of multituberculates, a small mammal from the Cretaceous characterized by their very interesting and very bumpy teeth. Luke Weaver, a PhD candidate from the Wilson Lab at the University of Washington visited the museum in Summer of 2018 to check out the collection and further his own research into these interesting creatures. His visit was supported in part by the Doris O. and Samuel P. Welles Research Fund. Check out the video for more on these … [Read more...] about Fossil Feature: Multituberculates
Are There Dinosaur Bones in UC Berkeley's Campanile?
KQED's Bay Curious asks: are there dinosaur bones in UC Berkeley's Campanile? UCMP's Pat Holroyd and Leslea Hlusko answer this question. … [Read more...] about Are There Dinosaur Bones in UC Berkeley's Campanile?
25 years of the UCMP website
Forgive us. We nearly didn't notice until late 2018 that the year marked the 25th anniversary of the UCMP website! We decided that early 2019 was a good time to celebrate that milestone since the site is undergoing a somewhat radical redesign, only the fourth big design change in its history. We felt that this was also a good time to look back at those 25 years and pick out some of the highlights. I contacted website founders Rob Guralnick, currently Associate Curator of Biodiversity … [Read more...] about 25 years of the UCMP website
Reading between the rocks: Reinterpreting the Late Ordovician mass extinction
This past summer, I had the opportunity to conduct my first field season on Anticosti Island (Québec, Canada). Located in the subarctic of Canada, Anticosti Island preserves a 200 kilometer-long transect of ancient seafloor. Late Ordovician tropical reefs and fossils are beautifully preserved across the island in towering coastal cliffs and river canyons. The sheer size of the island is astounding, and the insight its fossil record could provide into early Paleozoic marine communities is … [Read more...] about Reading between the rocks: Reinterpreting the Late Ordovician mass extinction
Science and the arts are not incompatible
Working in a paleontology prep lab as an Anthropology major who leans towards cultural analysis was something that seemed out of left field for me. I was sitting in the corner of a lab that was strewn with rocks and fossils that I didn't know yet were fossils for my job interview, and I was asked to give more detail on my experience in art. I didn't really expect it to be something that would be so important to my job here at the Museum of Paleontology, but my experience outside of the "hard … [Read more...] about Science and the arts are not incompatible
Working in the UCMP fossil prep lab
Throughout my whole life I have known that I would make my passion my career someday. However, the road to success in vertebrate paleontology can be a rocky one (no pun intended), sometimes without direction or opportunity. Fortunately, the University of California Museum of Paleontology seeks to help aspiring scientists, such as myself, obtain hands-on experience in the field of paleontology! My name is Julia Anderson, and I am a senior undergraduate student, actively seeking my place amongst … [Read more...] about Working in the UCMP fossil prep lab
The Tale of Sandbox Whale
One of the exciting projects we worked on in the prep lab was the assembly of the remains of a whale skull, known as "Sandbox Whale". The project, from its plaster jacket beginnings to the finished product, relied on various skills that we have learned in the prep lab. I find that most of our projects, like the Sandbox Whale, require creativity and patience. The opening of the rigid plaster jacket required the use of wet rags to loosen the jacket so we could rip it open. This is a clever … [Read more...] about The Tale of Sandbox Whale
How often does extreme competition occur between species on the ocean floor?
Look around in nature or even in the city and you will see that organisms are not static entities, but interact with one another. Think of a robin with a worm in its beak, a tick crawling on your leg looking for a spot to puncture your skin, or two bucks fighting during the rutting season for the right to mate. The sea floor is also a place where animals search or fight for food to stay alive. On the continents, food is not unlimited; every individual tries to collect a piece of the pie (Fig. … [Read more...] about How often does extreme competition occur between species on the ocean floor?
2018 Spring Break Field Trip
Four states, nine days, 2,850 miles, 48 hours cumulative driving and enumerable sponges. The Field Methods in Paleobiology Course, also known as the 2018 Spring Break Field Trip, from March 24, 2018 to April 1, 2018, was a whirlwind tour of the Southwest with IB Faculty/UCMP Curators Cindy Looy, Ivo Duijnstee and Seth Finnegan leading a group of students, a professor on sabbatical and one staff member to West Texas to the explore the ancient Capitan Reef formation in and around Guadalupe … [Read more...] about 2018 Spring Break Field Trip
UCMP now has over 100,000 cataloged invertebrate specimens
Thanks to our recent digitization projects, UCMP now has topped 100,000 cataloged invertebrate specimens! At least 6500 of these are fossil insects, millipedes and spiders digitized by Dr. Diane Erwin and undergraduate students under Berkeley's Fossil Insect PEN. Helping make all this possible was the work by the following participants: Dr. Marwa Wafeeq Abdelkhaliq Ibraheem (Ain Shams University, Egypt; volunteer), graduate students Winnie Hsiung and Rosemary Romero, as well as undergraduate … [Read more...] about UCMP now has over 100,000 cataloged invertebrate specimens
Russell Waines' stromatoporoid collection
Russell H. Waines was a geologist who dedicated most of his life to ancient sponges, the stromatoporoids, which were one of the most important reef builders during the Paleozoic. When I was a graduate student researcher at the UCMP in 2013, I had the pleasure of organizing this collection (Figure 1), which includes approximately 2000 fossil specimens (566 of which are registered in the UCMP database) mainly from the Devonian of Nevada, but also from Alaska, Arizona, California, New York, Utah, … [Read more...] about Russell Waines' stromatoporoid collection
Exploring Annie Alexander's Saurian Expedition of 1905
In 1905 UCMP benefactress Annie Alexander financed and took part in an expedition to the West Humboldt Mountains of Nevada to collect vertebrate fossils in the Triassic limestones. The crew came home with portions of some 25 ichthyosaur skeletons. Alexander put together a scrapbook containing her chronicle of the trip and many photographs; the scrapbook was given to UCMP following Alexander's death in 1950 and is one of the most treasured items in the museum's archives. Up until now, the … [Read more...] about Exploring Annie Alexander's Saurian Expedition of 1905
Guest lecturing at Los Medanos Community College
Roughly 10 million students attend American community colleges each academic year, accounting for more than a third of all American undergraduates. Relative to their peers at four-year institutions, community college students are much more likely to come from lower income households, much more likely to be members of an underrepresented minority group, and much more likely to be a first-generation college student. I was lucky enough to spend three years as a faculty member of a Denver-area … [Read more...] about Guest lecturing at Los Medanos Community College
2017 Fossil Treasures Calendar Available Now!
Revealing the collections at Regatta The 2017 Fossil Treasures Calendar is a bit of a 'behind-the-scenes' look at the work done at UCMP and celebrates some impressive fossil specimens we hold at the Regatta Facility in Richmond, CA. We have both fossils large in size and large in number and featured in this calendar are the large antlers from the giant elk, hundreds of vials of microfossils and even dinosaur fossils formerly on display at Cal Academy, namely the legs of the Allosaurus. So get … [Read more...] about 2017 Fossil Treasures Calendar Available Now!
Hiep Nguyen's UCMP undergraduate research experience: "Scentless in Nevada"
This past year, I've been working with UCMP Senior Museum Scientist Diane M. Erwin to identify a new fossil species of scentless plant bug (family Rhopalidae) from a Miocene lakebed deposit in Stewart Valley, Nevada. The study developed as a result of my participation as an Undergraduate Research Apprentice (URAP) in UC Berkeley's Fossil Insect Digitization PEN project (BFIP) funded by the National Science Foundation. The BFIP project is part of the Fossil Insect Collaborative Thematic … [Read more...] about Hiep Nguyen's UCMP undergraduate research experience: "Scentless in Nevada"
Meschelle Thatcher's UCMP undergraduate research experience: Beetles in Brea!
As an English major, I didn't really know what to expect when I first started my URAP (Undergraduate Research Apprenticeship Program) appointment for the UC Museum of Paleontology Fossil Insect PEN (Partner to an Existing Network) funded by the National Science Foundation. All I knew was that I'd be handling fossils, and that struck the scientific chord in my imagination in perfect harmony. The Pleistocene Rancho La Brea tar pits in southern California are best known for their extinct exotic … [Read more...] about Meschelle Thatcher's UCMP undergraduate research experience: Beetles in Brea!
Our journey from the UCMP to South Africa to study fossil monkeys
At the time we got involved in what has now become for us - the South Africa project - one of us (Tesla) was soon-to-be a second year graduate student, and the other (Marianne) was about to start her senior year as an undergraduate student here at UC Berkeley. We began working together in the UC Museum of Paleontology (UCMP) during the summer of 2013, making our way through a massive project and cataloguing exceptional fossil material collected during the UC Africa Expedition of 1947 and 1948. … [Read more...] about Our journey from the UCMP to South Africa to study fossil monkeys
A first: Sauropod bones found in Ethiopia!
Assistant Director Mark Goodwin and his project collaborators (see Feb. 1 blog post) made a surprising discovery while collecting microvertebrates, turtles, and fish. Within a small area of exposure in the Late Jurassic Agula Shale in the Tigray Province, just south of Mekele, Ethiopia, were the first sauropod dinosaurs ever reported from Ethiopia! The team found mostly partial bones and bone fragments, and the local school kids delighted in holding Ethiopia's first sauropod dinosaur bones. … [Read more...] about A first: Sauropod bones found in Ethiopia!
Bones in the Belltower, a Berkeley Science Review feature by Sara ElShafie
The Fall 2015 issue of the Berkeley Science Review features an article by Sara ElShafie, a UCMP graduate student in the Padian Lab, on the McKittrick tar seep fossils that have been stored in the Campanile since the 1930s. The convergence of an Institute of Museum and Library Services grant to the UCMP to clean and catalogue more the 12,000 specimens in the collection and the centennial celebration of the Campanile in 2015 shined a spotlight on these unique fossils. In interviews with UCMP … [Read more...] about Bones in the Belltower, a Berkeley Science Review feature by Sara ElShafie
The 2016 Fossil Treasures Calendar is now available at UCMP
Sharing the Collections at UCMP The new year's calendar focuses on the collections and the unique specimens that can be found here. UCMP is a research museum, which means that access is limited to researchers, our students, and affiliates. The 2016 calendar allows us to bring the collections to our supporters and the general public. Grants from the National Science Foundation and the Institute of Museum and Library Sciences enabled us to restore, catalog and digitize new specimens more rapidly … [Read more...] about The 2016 Fossil Treasures Calendar is now available at UCMP
UCMP volunteers discover important specimen
UCMP volunteers Kathy Zoehfeld and Don Pecko recently discovered a type specimen from the Smithsonian National Museum of Natural History among the hundreds of thousands of fossils in the former USGS Menlo Park collection. This type specimen, a tiny gastropod called Ceratia nixilia, was discovered in a drawer of fossils they were rehousing into new archival boxes. Don and Kathy not only noticed the less than a centimeter long gastropod, but brought it to my attention because they noticed the … [Read more...] about UCMP volunteers discover important specimen
Fossils in the Campanile? It's true!
If you have taken the elevator to the top of Sather Tower, aka the Campanile, perhaps you've heard that some of the floors of the tower are filled with fossils. This is not a campus myth, it's fact! The Campanile is celebrating its 100th anniversary this year and its very first occupants — moving in before the tower was even completed — were fossils. At that time, the museum and Department of Paleontology were in Bacon Hall, just east of the Campanile, so as a storage facility, the … [Read more...] about Fossils in the Campanile? It's true!
Encounters in the field: UCMP and the US Geological Survey
Hundreds of specimens from the former USGS Menlo Park Collection, now housed in the UC Museum of Paleontology, were collected in the pioneering days of geological and paleontological exploration of California. This includes fossils collected by Charles A. White, Timothy W. Stanton, Joseph S. Diller and other legendary figures at the US Geological Survey. The newly founded Department of Paleontology at UC Berkeley also led numerous expeditions and excavations of vertebrates in California in the … [Read more...] about Encounters in the field: UCMP and the US Geological Survey
Cataloging the archives: Paleontology specimen exchange
How do natural history museums build their collections? The UCMP's fossil collection is largely a product of decades of field work by past and present researchers. As the State's fossil repository, the museum also receives a large number of fossil finds from construction sites in California (for example, the Caldecott Tunnel). Another, perhaps less appreciated means of acquiring scientifically valuable specimens, is specimen exchange between institutions — it's a bit like a holiday gift exchange … [Read more...] about Cataloging the archives: Paleontology specimen exchange
Finding forams in the Caldecott Tunnel
Day after day, over the course of two years, the massive tunnel borer worked its way through the sedimentary rock layers of the Berkeley Hills during the construction of the fourth bore of the Caldecott Tunnel, grinding up the rocks in the process into fist-size pieces that were later deposited outside the entrance of the tunnel. At the end of each work day, paleontologists sifted through these piles, referred to as the day's "spoils." They were not only on the lookout for fossils of plants and … [Read more...] about Finding forams in the Caldecott Tunnel
Prepping the fossils from the Caldecott Tunnel
For the last semester I have been lucky enough to work as the GSR (graduate student researcher) for the spring semester at the UC Museum of Paleontology fossil preparation lab (prep lab) under the supervision of our new lab manager, Jason Carr. It has been fun getting back into the preparation role, something that I did as a job after college. The material we have to work on varies a lot which keeps the work interesting. It requires a variety of techniques, so I get to do something different … [Read more...] about Prepping the fossils from the Caldecott Tunnel
Reports from Regatta: Two Cal Alumni and the USGS Menlo Park Collection
As undergraduate work-study students recataloging the United States Geological Survery (USGS) Menlo Park Invertebrate collection at the UCMP, we've come across the names Nelson and Addicott time and time again in extensive database entries or on the original, yellowing locality cards paired with each specimen. The names of the paleontologists and geologists responsible for collecting these fossils in the Menlo Park collection are largely unknown to us, but found immersed within the aging drawers … [Read more...] about Reports from Regatta: Two Cal Alumni and the USGS Menlo Park Collection
Cataloging the Archives: Three Fine Trikes
Another in a series of blog posts relating to the museum's "cataloging the archives" project Ask children what their favorite dinosaurs are, and it's almost guaranteed that Triceratops (refer to them by their nickname, Trikes, and you'll earn tons of street cred) will be on the list. The three-horned, frilled wonder is one of the most recognizable creatures of the Cretaceous. Many a visitor has walked by the Triceratops display here in the Valley Life Sciences Building's Marian Koshland … [Read more...] about Cataloging the Archives: Three Fine Trikes
The Arrival of the Fossils
The UCMP houses one of the largest fossil collections associated with a university in the world, so it is no wonder that some of the fossils need to be stored off-campus at the UC Regatta facility, located nearby in Richmond. This large warehouse is home to multiple campus-wide museum collections, including a variety of enormous whale skulls, huge ichthyosaur skeletons, and cyclopean bones of mammoths and dinosaurs from the Museum of Paleontology. The Regatta facility is also the current … [Read more...] about The Arrival of the Fossils
Fossil neighbors
About once a month, I drive from Berkeley to Walnut Creek to pick up specimens for my thesis (dead birds for a study of the evolution of development in Aves), which necessitates a pass through the Caldecott Tunnel. Each time, I heave a sigh and try to shore up my patience as traffic before the tunnels slows to a stop. However, this bane has recently metamorphosed into an object of great interest, for it has come to my attention that the construction here is also uncovering of one of Earth's most … [Read more...] about Fossil neighbors
Cataloging the archives: Chaney, the Emperor and Metasequoia
Another in a series of blog posts relating to the museum's "cataloging the archives" project The UCMP archives contain five large scrapbooks containing museum-related newspaper clippings dating from 1948 to 1989. The earliest clippings in the oldest scrapbook concern UCMP paleobotanist Ralph Chaney's 1948 trip to central China to see for himself, Metasequoia, a tree thought to have been extinct since the Miocene. The existence of this living fossil had just been publicized in a paper by Hu and … [Read more...] about Cataloging the archives: Chaney, the Emperor and Metasequoia
A special night at UCMP
Cal Day is the one day of the year when lucky members of the public can tour UCMP's collection. But this year, on the night before Cal Day, UCMP hosted a special event to take some of our closest friends behind the scenes. This invitation-only event included sneak previews of Cal Day exhibits, tours of the collection, the paleo art of William Gordan Huff, and fossils recovered during the construction of the Caldecott Tunnel's fourth bore. UCMP-affiliated faculty curators, scientists, … [Read more...] about A special night at UCMP
Cataloging the archives: Geology camp 100 years ago
Looking at UCMP's modern offices and collections space, one might not appreciate that the paleontology tradition at Berkeley stretches back more than one hundred years. But now the CLIR/UCMP Archive Project is bringing this history to light. Some of the oldest supplemental locality files I have come across this semester contain class reports and geologic maps prepared by a Cal field geology class in the summer of 1911. Led by Bruce L. Clark, who eventually became the first director of the … [Read more...] about Cataloging the archives: Geology camp 100 years ago
Photo shoots for UCMP science
This semester, the UCMP has been excited to host a visiting photographer, UC alum Dave Strauss. A self-described "computer guy" for the last 42 years, he is also an avid naturalist, hiker, and mountain biker. Dave finds inspiration at the UCMP through the opportunity to use his talents to communicate evolutionary and historical knowledge to the broader community. Collaboration with Dave has provided many opportunities to contribute to science. He has confronted technical challenges … [Read more...] about Photo shoots for UCMP science
Cataloging the archives: Unearthing a type
This semester, one of the foci of the CLIR/UCMP Archive Project has been cataloging what are called "supplemental locality files." These files contain materials (other than field notes) that are relevant to UCMP collections, such as polaroid pictures of fossil sites, letters of correspondence involving UCMP scientists, and environmental impact reports for land development proposed in areas with known fossil sites. As such, they are unique records of how collections came to be, and how … [Read more...] about Cataloging the archives: Unearthing a type
The Amber Files: Words from the University Explorer
"More than 300 years ago, Sir Francis Bacon spoke of amber as 'a more than royal tomb' for tiny insects. Twentieth century scientists may quite agree." But how do insects end up as amber fossils? What else is found in amber? How are these amber fossils prepared for study? The answers to these questions can be found in one of the hidden collections of UCMP's archives — the 1561st broadcast of "The University Explorer." This show was narrated by Hale Sparks, former head of broadcasting … [Read more...] about The Amber Files: Words from the University Explorer
Relicts of the Bug-men
What are bug-men and how did their existence benefit UCMP? Watch and listen to this slideshow about an obscure link recently discovered by UCMP micropaleontologist Ken Finger. Click cover page below to download the full article. … [Read more...] about Relicts of the Bug-men
The Amber Files
Unbeknownst to some, UCMP is home to a large collection of amber-encased insect specimens. While some of the most famous amber fossils come from the region south of the Baltic Sea, the majority of UCMP's amber collection hails from the Chiapas region of Mexico, illuminating never before captured environments of the Western Hemisphere. Spanning nearly two decades from the mid-1950s through the 1970s, efforts to collect and study these specimens were spearheaded through collaboration between the … [Read more...] about The Amber Files
"Field Notes": Devonian liverworts and Permian conifers
On a cold Berkeley morning late in March paleobotanist Cindy Looy and grad student Susan Tremblay hopped on a plane to Washington DC. Their goal was not to enjoy the gorgeous spring weather and peaking cherry blossoms, but instead to search for clues to the early evolution of plants in the collections of the National Museum of Natural History (NMNH). Devonian liverworts and Permian conifers were on the menu. Pallaviciniites devonicus, described by Francis Hueber in 1961, is one of the oldest … [Read more...] about "Field Notes": Devonian liverworts and Permian conifers
Cal Day 2011 is here!
It's that time of year we've all been waiting for: Cal Day! This Saturday marks the one day a year UCMP opens its doors to the public and plays host to a number of events aimed to expose all those who are interested to the fascinating world of fossils. Stop by the Valley Life Sciences Building for festivities that range from digging for bones to learning about climate change. Found a fossil you need identified? Our experts have set up shop to help you out with just that. Don't forget to … [Read more...] about Cal Day 2011 is here!
National Fossil Day at UCMP
Yesterday was the first ever National Fossil Day and UCMP pulled out all the stops! Come check out the new online exhibit, Fossils in our parklands: Examples of UCMP service and stewardship, featuring fossils in UCMP's collection from national and state parks in California, Nevada, Oregon, and Montana. The museum played a pivotal role in the creation of some of the featured parks and we're happy to highlight our shared histories. Additionally, the 2011 UCMP Fossil Treasures Calendar is now … [Read more...] about National Fossil Day at UCMP
Museum nomads
For many paleobiologists summer is that part of the year during which data is gathered in its purest form: fossils. Such summers may take you in diametrically opposite directions, though. Some bring broadly boasted outdoor adventures of fieldwork. Others, however, take you deeper and deeper into the collection labyrinths in the dark bowls of natural history museums around the globe. Despite what others may let you believe - and don't tell anyone we told you - fieldwork is often boring, tedious … [Read more...] about Museum nomads
X-ray analysis of fossil whale baleen
Two years ago I approached UCMP Assistant Director Mark Goodwin and asked if he had any room for some student help in his research. I had no previous experience in paleontology, just a passion for learning about dinosaurs and biology. Now, as a third-year graduate student in the Department of Materials Science and Engineering, I work on a variety of projects with Mark and the UCMP. For my own research, I study the micro- and nano-scale features in fossil bone with electron microscopy. I have … [Read more...] about X-ray analysis of fossil whale baleen
No backbones allowed
The UCMP Invertebrates Collection includes over 31,000 catalogued specimens! Corals, crabs, bivalves, snails, ammonites… both fossil and recent — if it doesn't have a backbone, it's in this collection. I am a UCMP and Integrative Biology graduate student and have been assisting with curation of the Invertebrate Collection. I catalogue and label specimens, process loan requests, manage the Invertebrates Collection database, curate private collections that are donated to the UCMP, and do numerous … [Read more...] about No backbones allowed
Flat Stanley visits the UCMP
The UCMP has hosted several Flat Stanleys this year, as part of the Year of Science 2009. Flat Stanley is a fictional character from a children's book, written by Jeff Brown in 1964. In the original story, Stanley is a little boy who is flattened when a bulletin board above his bed falls on top of him. He finds that, in his new flattened state, he is able to have many great adventures by being mailed from place to place in an envelope. Inspired by this story, the Flat Stanley project began as a … [Read more...] about Flat Stanley visits the UCMP
T. rex gets a manicure
A few months ago, the UCMP's Tyrannosaurus rex broke a nail. The right claw mysteriously went missing. We needed to replace it, but obviously the standard-issue drugstore press-on nail just wouldn't do. We had to re-construct a new right claw by making a copy of the intact left claw. Danny Anduza, a UCMP volunteer, carried out the claw restoration. First, he mixed up a rubbery substance and painted it over the T. rex's left claw, to make a mold. Once the rubber hardened, he carefully sliced it … [Read more...] about T. rex gets a manicure
Lupé's story: A mammoth's journey from the ground to a museum
In 2005, Roger Castillo found the fossilized bones of a juvenile mammoth in the Guadalupe River near San Jose. Roger was walking his dog along the river, which he did frequently as a volunteer for the Guadalupe-Coyote Resource Conservation District, when he saw the tusks of the mammoth's skull poking out of the soil along the riverbank. At the time he wasn't exactly sure what he was looking at but recognized their importance and contacted the UCMP. The fossilized mammoth has been named Lupé, … [Read more...] about Lupé's story: A mammoth's journey from the ground to a museum
Cal Day at the UCMP
The UCMP is open to the public just one day a year — Cal Day. Watch this video to see the UCMP's exhibits from Cal Day 2009. [flv:http://www.ucmp.berkeley.edu/images/video/CalDay20090828_1.flv 360 264] … [Read more...] about Cal Day at the UCMP


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Not really homesick but I thought it would be fitting to quote Bob Dylan... So I had an awesome adventure taking the Subte- or Subway... As I headed into the underground to try the Subte for the first time I got a rush of adrenaline. Not only did I not grow up with a subway, but I've never lived anywhere with one either and really only been in one in Boston years ago and wasn't in charge of the negotiation.
Earlier today I saw the entrance to the Subte around the corner from my hostal so I knew the name of the station where I was headed- Avenida de Mayo. So I figured how hard can it be? Look at the map and follow it to where I need to go. I wanted to get from Palermo, where I was visiting Ana before she left for Chile, to the center of the city, where my hostel is. It started out good... I got from Palermo to close to the center, switched trains, got on the wrong direction and the switch, got off at the next stop and managed to get on the right direction. I thought I was home free with only two stops to go. At the stop before I needed to exit about 50 people piled in and the train was smashed full. I mean sardines... an understatement. So the train gets to my stop and no one moves. I'm stuck. The doors close and we're off. Damn. So I figure I'll just get out at the next stop and switch to the train going the other direction. As we approach the next stop, I start making eye contact with the people between me and the door. I get some sort of acknowledgement. The train stops, the doors open and no one moves. "Screw it!" I think, and just push for the door, not sure if I'll make it or not. But I seem to slip through inch by inch... I hear the alarm sound for the doors to close... with a mini panic I thrust for the opening and with a whoosh I'm out on the platform and the train is already zipping away.
After a quick breath, I check myself. I seem to have all my belongings, at least I think. I still got my pack on, with Johnson's several thousand dollars worth of camera gear in it. Well all I have to do is get on the train going back the other way. I think... Easy enough. But when I go up a level to cross to the other side my ticket won't work. Instead of paying another 70 centavos, roughly 25 cents, I decide to walk. I exit this underground wormhole, check my bearings and start heading for the hostel. I walk about a half mile and realize I'm nowhere I've ever seen before. Dreading ending up in the rough Italian district of Boca, or really anywhere now that it is dark, I head for the nearest Subte entrance and consult the map, trying not to look lost. Turns out that this subterranean adventure has entirely confused my internal compass and left me heading in exactly the wrong direction.
I made an about face and started my 3/4 mile walk in the "right" direction. Bummed about my underground escapades, I shun the Subte, grab my packstraps and start hoofing it down the sidewalk. 20 minutes later I'm at the hostel. Sweaty, sucking down a 32 oz. Heineken to the tune of two bucks, laughing to myself knowing full well without these "adventures in err" I'd have no story.
So with unparalled consensus, I understand no one wants to hear about the color, consistency or quantity of my snot. I apologize. I just wanted to keep it real. But you'll all be happy to know that every minute there is less. And now it is clear. Soon I'll be back to healthy and then who knows what will limit me? My limp? Still noticeable, is getting better everyday too. Hope you are all well. Drop a note, comment or anything else. With much love and aloha, -g.
P.S. Sorry no pictures lately. The computers have been a little shady lately. I'll post some soon. Stay tuned and keep commenting.
My 2019: Day In Review
3 months ago

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Safety Issues With Gilenya
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Specific Precautions and Warnings With GilenyaSome warnings and precautions to be aware of prior to taking this drug include the following:
- Gilenya has a tendency to lower the heart rate, especially after the first dose. Because this can occasionally be dangerous in some individuals, you will begin Gilenya treatment in a medical facility. Your healthcare provider will check the electrical activity of your heart, with an electrocardiogram (ECG), before you start Gilenya, and then monitor your heart rate and blood pressure every hour for at least six hours after you take your first dose. Six hours after your first dose, you will have another ECG.
If you experience serious side effects, you will need to be monitored overnight, and again for at least six hours after you take your second Gilenya dose. People with certain types of heart problems or who take certain medications that affect the heart will automatically be monitored overnight after taking their first Gilenya dose.
Typically, your heart rate will return to normal within the first month while taking Gilenya. You will need to follow these same first-dose precautions again if you stop taking this medicine for more than a day during your first two weeks of treatment, more than seven days during your second or third weeks of treatment, or two weeks or longer any time thereafter.
- Gilenya decreases the body's ability to fight infections. In rare cases, this can result in life-threatening infections. You should contact your healthcare provider right away if you develop any signs or symptoms of an infection (such as a fever).
- If you have never had chickenpox and have not had the chickenpox vaccine, your healthcare provider should run a blood test to see if you are susceptible to this infection. You may need to receive the chickenpox vaccine and wait one month before starting Gilenya. Getting chickenpox while on Gilenya can be quite serious.
- Gilenya can cause swelling of the macula of the eye (macular edema). If you have diabetes or uveitis, you have a higher risk for this side effect of Gilenya. Your healthcare provider should test your vision before you start this medication and again three to four months later. Let your healthcare provider know if you develop any vision changes.
- Gilenya can decrease your lung capacity and cause shortness of breath. Let your healthcare provider know if you develop any breathing difficulties.
- Gilenya can cause high liver enzymes (found using a blood test). Because your healthcare provider will need to know your "baseline" levels (in case you develop possible liver problems), your liver enzymes should be tested before you start this medication. This is a simple and common blood test. Let your healthcare provider know if you develop signs of liver problems, such as abdominal pain, nausea and vomiting, fatigue, loss of appetite, dark urine, or yellowing of the skin or whites of the eyes (jaundice).
- Gilenya can raise blood pressure. Your healthcare provider should monitor your blood pressure regularly.
- Gilenya can interact with a number of other medications (see Gilenya Drug Interactions).
- Gilenya is considered a pregnancy Category C medication. This means that it may not be safe for use during pregnancy, although the full risks are unknown (see Gilenya and Pregnancy).
- It is unknown if Gilenya passes through breast milk. Therefore, if you are breastfeeding or plan to start breastfeeding, discuss this with your healthcare provider prior to taking the drug (see Gilenya and Breastfeeding).
Gilenya Medication Information
Gilenya [package insert]. East Hanover, NJ: Novartis Pharmaceuticals Corporation;2012 May.
Food and Drug Administration (FDA) news release. FDA Drug Safety Communication: Revised recommendations for cardiovascular monitoring and use of multiple sclerosis drug Gilenya (fingolimod). May 14, 2012. Available at: http://www.fda.gov/Drugs/DrugSafety/ucm303192.htm. Accessed May 28, 2012.


text: Monthly Archives: August 2015 Free Five Points Pizza and our favorite on-the-go East Nashville eats Sure, you may only be saving four or five bucks, but there's something about the allure of free pizza that makes East Nashville restaurant Five Points Pizza's birthday celebrations something… Written by Ashley Dugger August 28, 2015 No Comments Enter to win tickets to September's 3st of the Month! Whiskey fanatics: September is your month (it's Bourbon Heritage Month, specifically), and 3st of the Month has your ideal celebration plans taken care of. Well, "taken care of" isn't… Written by Ashley Dugger August 24, 2015 2 Comments Be a kid again (with grown-up perks) at Camp No Counselors Bunking up in cabins, scavenger hunts, arts and crafts, swimming, making new friends that you'll share summer memories with for years to come… all sounds like the stuff of sleepaway… Written by Ashley Dugger August 19, 2015 No Comments Franklin's Pilgrimage Music & Cultural Festival kicks off its first year If you tend to feel somewhat lost during the months between each annual Bonnaroo Music and Arts Festival, 2015 brings you a welcome new friend: the Pilgrimage Music & Cultural Festival, kicking… Written by Ashley Dugger August 18, 2015 2 Comments Music City Hot Wing Festival, by the numbers Sorting out your mid-August weekend plans? We put together a recent rundown of festivals happening in and around Nashville this month and next, but let's go a little deeper into… Written by Ashley Dugger August 12, 2015 No Comments Home design trends of 2015, and finding them in Nashville PureWow recently shared its picks for the Top 10 Home Design Trends of 2015, and there are definitely some good looks in the mix — aesthetics we see popping up… Written by Ashley Dugger August 11, 2015 No Comments The Gulch Gives Back helps fund Make-A-Wish wishes in Nashville area We all know about the wonderful work the Make-A-Wish Foundation does, granting the wishes of children with life-threatening medical conditions, spreading a bit of happiness and goodness in the face… Written by Ashley Dugger August 4, 2015 No Comments Thinking about moving to Midtown? The Nashville TV series has been bringing people to set roots in Nashville in indirect and very direct ways. The Tennessean shared a tidbit this week about director Michael Lohmann,… Written by Ashley Dugger August 4, 2015 No Comments About our blog Our agents write often to give you the latest insights on owning a home or property in the local area. Recent Posts Nashville Neighborhood Spotlight: 12 South ACRE Client Spotlight: Lauren Beasley of MOVE Inclusive Dance Is owning a short-term rental in Nashville in your future? You're too late to buy Carrie Underwood and Mike Fisher's Brentwood home Grow a rainbow in your Nashville garden Archives April 2019 February 2019 January 2019 December 2018 November 2018 October 2018 September 2018 August 2018 July 2018 June 2018 May 2018 April 2018 March 2018 February 2018 January 2018 December 2017 November 2017 October 2017 September 2017 August 2017 July 2017 June 2017 May 2017 April 2017 March 2017 February 2017 January 2017 December 2016 November 2016 October 2016 September 2016 August 2016 July 2016 June 2016 May 2016 April 2016 March 2016 February 2016 January 2016 December 2015 November 2015 October 2015 September 2015 August 2015 July 2015 June 2015 May 2015 April 2015 March 2015 February 2015 October 2014 September 2014 August 2014 July 2014 June 2014


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See The Hazel Wood in our catalogue
"17-year-old Alice and her mother have spent most of Alice's life on the road, always a step ahead of the strange bad luck biting at their heels.
"But when Alice's grandmother, the reclusive author of a book of pitch-dark fairy tales, dies alone on her estate - the Hazel Wood - Alice learns how bad her luck can really get. Her mother is stolen away - by a figure who claims to come from the cruel supernatural world where her grandmother's stories are set.
"Alice's only lead is the message her mother left behind: 'Stay away from the Hazel Wood'. To retrieve her mother, Alice must venture first to the Hazel Wood, then into the world where her grandmother's tales began."
Fairytales just got darker. These aren't the saccharine Disney versions of your childhood; these are dark, creepy and bizarre.
My favourite parts of The Hazel Wood are definitely the extracts from Alice's grandmother's book, Tales from the Hinterland. The author plans to publish a full collection of the tales in 2020, and I can't wait. The stories are just so intoxicatingly creepy and dark.
The Hazel Wood is a mesmerizing, intriguing debut that will sweep you off your feet.


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Wednesday, November 28, 2018
Doomsday Clock #6
30 comments:
Wait -- didn't the Comedian die on about page three of Watchmen?ReplyDelete
"Who killed the Comedian" was kind of the whole story.ReplyDelete
But in this version, Doctor Manhattan caught him before he hit the ground and transferred him to DC earth,ReplyDelete
Silly me.ReplyDelete
Because that's exactly the kind of thing Dr. Manhattan would do.
Is the Marvel Universe the most complicated fictional invention ever (and if it isn't, what is)?ReplyDelete
If, by complicated you mean "the most number of characters and settings developed over the largest amount of time, and with the most detailed 'theology' underlying it" then that would be the DC Multiverse. (Marvel has lots of characters and settings, but has on the whole avoided multi-dimensional Crisis). The Doctor Who Universe probably comes a close second, although I prefer Elisabeth Sandifer's concept of "sentient metafiction".ReplyDelete
(If by "complicated" you mean "hard to understand" or inaccessible to the newcomer, then not so much. Very little of this stuff matters in the actual comics, at any rate not the good ones. e.g Ms Marvel works brilliantly as a story about teenagers in New Jersey one of whom has Amazing Powers. Any Marvel Universe Stuff you need to know gets explained as you go along.)ReplyDelete
The Doctor Who Universe probably comes a close second, although I prefer Elisabeth Sandifer's concept of "sentient metafiction"ReplyDelete
Those are both wrong (although one's significantly more mad). Doctor Who is an anthology series with shared characters, that occasionally contains sequels to earlier stories; it isn't and was never intended to be one continuous fictional reality like, say, Middle-Earth. And even the sequels aren't supposed to really be in the same reality: The Dalek Invasion of Earth is 'another story with Daleks in it', it's not supposed to be in any way taking place in the same universe as The Dead Mutants. Terry Nation certainly never considered that it might be taking place in the same universe; his perfunctory addressing of the issue is almost deliberately nonsensical. He was just asked to write another story with Daleks in and, because they were paying him for it, he did.
There's no more a 'Doctor Who Universe' than there is a, I don't know, 'Robin Hood Universe' where somehow all the different stories ever told about Robin Hood are simultaneously true and all happened to the same fictional character.
[I dont know enough about comics to speculate on how this applies to them, but I know far more about Doctor Who than any adult reasonably should]
Agreed. Taron Egerton can no more say "I remember that time I was a fox" than Jodie Whitaker can say "I remember that time I was Matt Smith."ReplyDelete
Ah, that's a different thing. There's an implied continuity of the Doctor, but not the universe. Really the best way to think of it is that every time the Doctor steps out of the TARDIS it's into a totally different story, with its own universe (and, sometimes, its own story-physics — certainly usually its own time-travel-physics, as time-travel rarely works the same way in two different Doctor Who stories).ReplyDelete
And when the Doctor steps back into the TARDIS, the story ends and the world just much as, say, Europe disappears at the end of Casablanca, unless it's needed for a sequel (and even then usually it makes more sense to assume the sequel takes place in a different universe, not a continuation of the same one: see all the Dalek and Cyberman stories, for example, which make no sense at all if you try to put them into a coherent continuity with each other, let alone try to put both sets together — as they were never intended to).
From your Spider-Man articles I gather that there was an intent to create the impression that there was a fictional universe in which Spider-Man might be walking down the street and bump into the Hulk. But the idea that the Ice Warriors might be wandering around in a starship and bump into the Wheel in Space was never intended and is frankly just nonsensical.
[Sorry, I have a bee in my bonnet about this ever since I was in the Canon Wars. I saw NAs on fire off the shoulder of Zagreus; I watched the Crystal Bucephalus glitter in the dark near Faction Paradox. And it was all for nothing, all for an illusion of a universe that never existed and was never intended to exist.]
"And when the Doctor steps back into the TARDIS, the story ends and the world just much as, say, Europe disappears at the end of Casablanca".ReplyDelete
I think that's true of some seasons. It's certainly not true of Seasons 5 and 6 (the first two with Matt Smith), which each have their own continuity. But you can argue that season 6 happens in a different universe from season 5.
What about the idea that the Ice Warriors might be present at peace conference on Peladon?ReplyDelete
What about the idea that there might be specimen Daleks in the space museum?
What about the idea that the Doctor might cite "Daleks, Cybermen, Ice Warriors" when arguing his case at a trial?
What about the idea that the Master can be engineering a war between the Humans and the Draconians and the Daleks can turn out to be behind it (kind of).
What about the idea that the Brigadier can refer to "that business with the Yeti" and "that business with the Cybermen" during a story about the Autons?
What about the idea that Captain Yates has to spend some time in a Buddhist Monastery to make up for trying to destroy human civilization with time traveling dinosaurs.
What about the Doctor bringing about a blue crystal from Metabelis III at the end of Season 9 and the giant spiders coming after it in Season 11.
What about every story with Davros in it.
What about Jo Grant being Jo Smith when she turns up in the Sarah Jane Adventures; or Cole Hill School having a governor called Chesterton...
Andrew, there is a difference between fan-service and universe-building.ReplyDelete
Also: Big Finish, Virgin and the New Adventures are part of Doctor Who, and they certainly developed their own canon and their own continuity. You may say that they ought not to have done, but they certainly did.ReplyDelete
It is, of course, trivially true that if you treat the bits of Doctor Who which were interested in universe building and continuity as "non canonical" than nothing in the Doctor Who canon is interested in universe building and continuity.
There is. But the sheer amount of internal referencing going on in old Who makes the claim "no-one thought that it was all going on in one setting" quite hard to sustain.ReplyDelete
I think it is quite obvious that the writers of old Who did think that it was all taking place in one universe, but thought that the universe was so vast that they didn't go to any great trouble to keep it consistent.
I do of course agree that the aesthetic of pre-Nathan Turner Who is such that anyone who spends much time trying to understand the back story and the continuity has probably missed the point.
But the sheer amount of internal referencing going on in old Who makes the claim "no-one thought that it was all going on in one setting" quite hard to sustain.ReplyDelete
If there had been any attempt to keep that 'internal referencing' consistent, then I'd agree — but there wasn't. The Dalek turning up in the space museum, for example, is, as Mike Taylor says, simply service for the fans: it doesn't make sense on any logical 'consistent universe' level, and nor is it meant to. It's just set dressing for the audience.
Most of your examples are what I have called above 'sequels' (the UNIT stories are all kind of sequels to each other, and anyway that era is rather atypical for Doctor Who and most of it's crap so it's probably best to ignore it) and, as I wrote above, considering them as part of a continuous universe usually actually makes them make less sense (The Ice Warriors turning up on Peladon, for example, when in The Ice Warriors they had been extinct since before the last ice age — yes, you can make up some fanwanky guff about some leaving Mars before it died and colonies and yadda yadda but you know, and I know, that that wasn't the intent, any more than there was an intent to make The Dalek Invasion of Earth consistent with The Mutant Planet and you're just papering over the cracks).
I think it is quite obvious that the writers of old Who did think that it was all taking place in one universe, but thought that the universe was so vast that they didn't go to any great trouble to keep it consistent.ReplyDelete
How many different, and totally irreconcilable, versions of the twenty-first century are there in seasons four, five and six alone? At least three, I think?
Don't you remember how The Terrestrial Index had to have humans abandoning spaceflight, re-embracing it, then abandoning it again, then the Earth nearly being destroyed by Salamander, then finally deciding spaceflight was the way to go after all, all within the space of about thirty years, and it stilldidn't quite work with how long the rockets were supposed to have been in that museum? And that was all stories made by the same production team! They clearly didn't give a fig about the peculiar fan idea that if the Doctor landed in 2067, and then a couple of stories later landed in 2068, the two should look at all similar or that, say, the second one couldn't say that aliens had laid waste the planet five years previously.
"the UNIT stories are all kind of sequels to each other, and anyway that era is rather atypical for Doctor Who and most of it's crap so it's probably best to ignore it)"ReplyDelete
Sounds dangerously like 'Let's ignore everything I don't think fits in with my idea'
But I don't think there's any contradiction between saying 'Doctor Jody is exactly the same person as Doctors William through to Peter C and has had all those adventures' and 'but the writers haven't been consistent as to the details of those adventures'
The ordinary viewer thinks, and is intended to think, that the Brigadier lives on a planet called Earth, which is one planet in a universe full of aliens and monsters; and that the Doctor has helped him at various times; and that the Doctor travels around that universe encountering monsters and aliens. The ordinary viewer isn't surprised that the Master can meet the Daleks (as they would be surprised if one of the medics from Casualty turned up in Eastenders). And he certainly doesn't perceive it as a weird narrative dissonance, as he would if, say, Inspector Morse had to investigate the murder of Ivor the Engine.ReplyDelete
"There is no consistency between the depiction of 2068 and 2069, ergo every Doctor Who story is a part of a separate and unrelated story world" is itself a terribly fan-centric way of looking at things.
The ordinary viewer isn't surprised that the Master can meet the Daleks (as they would be surprised if one of the medics from Casualty turned up in Eastenders).ReplyDelete
Actually, I don't think one of the medics from Casualty turning up in Eastenders would confuse casual viewers at all: they'd see it as an Easter Egg, a crossover, two usually-separate stories crashing into each other for a bit of fun. Same as when, like, Fox Mulder turns up in TV series that aren't The X Files.
They wouldn't see it as a sign that all these TV series are supposedly taking place inthe same fictional universe (apparently, via crossovers, you can connect the Law and Order franchise with The X Files).
And, I suggest, the casual viewer of Doctor Who sees the Master teaming up with the Daleks the same way. It's two separate story elements that don't usually belong in the same world crashing into each other for a bit of fun, and when it ends it has no larger ramifications than that it was a bit of fun.
It no more means that the Master could accidentally off-screen land his TARDIS on Skaro than it does that when I watch the detectives from Law and Order: SVU try to work out who raped a poor girl, there is a vast conspiracy to breed aliens happening just out of sight.
When a character from one soap opera turns up in another soap opera, the audience is not confused, but mildly surprised. "That's cute. I didn't expect that." But there is no problem in accepting or accommodating it. Eastenders takes place in a real city called London, in a real country called England, which also contains another city called Bristol. No reason a Bristol medic might not happen to be in London on the day of the road accident. They instantly, and without thinking about it, modify their mental picture of the story world so that it contains both "The Queen Vic" and "Holby City Hospital". They absolutely do not do any of the fannish stuff about working about chronologies and time tables and family trees. (There is nothing wrong with that kind of fannish stuff: but it has to be acknowledged as a game.)ReplyDelete
If one of the Tellytubbies turned up in Albert Square; or if Jessica Jones was called in to solve a crime in Westeros the audience would recognize that something weird was happening: two elements of two very different story worlds were being brought together. Some kind of explanation would be expected -- it's a dream, someone is taking drugs, it's actually the landlady in a Tinkywinky Costume. You couldn't accommodate Tellytubbyland and Albert Square into one universe.
That most of Doctor Who is more like the first case and less like the second case seems entirely self evident.
It is also quite true that Doctor Who never had a Roy Thomas or a Mark Grunewald writing short-back up strips or text pages to resolve contradictions and weave narratives together.
If we are going to repeat the argument about whether anything at all exists outside of the actual text we have in front of us then I will respectfully bow out.
That most of Doctor Who is more like the first case and less like the second case seems entirely self evidentReplyDelete
No, Doctor Who is much more like the second case than the first, because what you've noticed is that crossovers are more striking when they take place between different genres. A crossover between two soap operas is easily accomodated. A crossover between a soap opera and a medical show, or a cop show, is more jarring but still easily papered over.
A crossover between a soap opera and a sci-fi programme on the other hand is harder — but didn't the Red Dwarf crash into Coronation Street a fewyears ago? I didn't see it but I understand it happened.
Simlarly while it might be hard to imagine Jessica Jones crossing over with Throne Games, it's easy to imagine that character interacting with characters from some cop show set in New York, or vice versa. But if that happened, the audience would not then expect that if, next episode, aliens landed a big spaceship in the New York of Jessica Jones, that that would be reflected in the cop show. Though they may share characters, they do not exist in the same universe. Events in one story do not affect the other.
And this is indeed how Doctor Who works: when, in one story, the Daleks move the whole of Earth across the galaxy, or when the Master takes control of the planet and shoots the US President on live TV, or when alien gaolers take over every TV screen in the world, it is understood that those events, unless otherwise specified, occured only in that story and have no wider repercussions: the next time the Doctor lands on Earth, people will be just as surprised to find out that there are aliens, despite the fact that they all saw them last time, because -- just like we understand that even though Jessica Jones and Blue NYPD Cops of the City can cross over, they are still separate stories, we understand that each Doctor Who story is a separate story.
But that's a distraction from the main point, which is: we've established the issue is one of genre. And Doctor Who is a multi-genre anthology series. Its stories take place in different genres. It would be just as weird as Teletubbies turning up in Albert Square to have, for example, a Sensorite waddling into a fun comedy scene where Nero is trying to rape one of the Doctor's companions.
Therefore it is entirely self-evident that Doctor Who is actually much closer to your second case than your first.
Plus UNIT dating.ReplyDelete
UNIT dating is Godwin of Doctor Who discussions.ReplyDelete
So that means I lose?ReplyDelete
Instead of having to say you lose, I think we can just agree that the discussion is over :-)ReplyDelete
It's my fault, it's what I get for knowingly overplaying a strong hand.ReplyDelete


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ORAL 13 - Immunotherapy Biomarkers (ID 104)
- Event: WCLC 2015
- Type: Oral Session
- Track: Biology, Pathology, and Molecular Testing
- Presentations: 1
- Moderators:D. Kim, D. Grunenwald
- Coordinates: 9/07/2015, 16:45 - 18:15, Four Seasons Ballroom F3+F4
ORAL13.05 - Predictive Biomarker Testing for Programmed Cell Death 1 Inhibition in Non-Small Cell Lung Cancer (ID 1081)
16:45 - 18:15 | Author(s): S. Zachara-Szczakowski
- Abstract
- Presentation
- Slides
Lung cancer is the largest cause of cancer-related mortality in the developed world. Advances in molecular targeted therapies have led to improved survival in a subset of non-small cell lung cancer (NSCLC) patients. Recently, inhibitors of the programmed cell death receptor 1 (PD1) have proven clinical efficacy in NSCLC. Only a subset of patients respond to PD1 inhibitors, likely reflecting variation in tumor-expression of the PD1 ligand (PD-L1). Many clinical trials have evaluated PD-L1 as a possible predictive biomarker for immune therapy; however several parallel and uncoordinated efforts have led to a high amount of heterogeneity, uncertainty, and ambiguity in the literature around PD-L1 and its use as a biomarker. We aim to investigate the feasibility of PD-L1 biomarker testing in NSCLC using immunohistochemistry (IHC).
Cases of stage II, surgically resected NSCLC, adenocarcinoma were identified retrospectively from the archives of the British Columbia Cancer Agency. A tissue microarray (TMA) was constructed with matched primary and metastatic lung tumors. IHC directed towards PD-L1 was performed with 3 different primary antibody clones: E1L3N (Cell Signaling Technology), SP142 (Spring Bioscience), and 28-8 (Dako), each stain was prepared using a unique protocol. Additional cases of NSCLC with available whole-genome sequence were also stained. Staining results were reviewed and scored by intensity of staining and the percentage of positive tumor cells. Cases with positive staining of any intensity in greater than 1% of tumor cells were considered positive (H score > 1). Clinical, pathological, and genomic features of PD-L1 positive cases were reviewed.
Eighty cases of NSCLC were identified and used in TMA construction. 78 cases had matched lymph node metastases included in the TMA. 29 cases (36%) were positive by the SP142 clone, 19 (24%) by E1L3N, and 27 (34%) by the 28-8 clone. The 3 clones showed concordant results in 61 (76%) of cases, 15 (19%) discordant cases showed low level staining with SP142/28-8 and no staining with E1L3N, 2 (2.5%) cases showed no staining by 28-8 with moderate staining by SP142/E1L3N. Lymph node metastases showed a concordant PD-L1 score in 65 (83%) cases, with no detectable trend in the discordance. Comparison of primary antibodies showed a high rate of concordance (κ=0.68). Exploratory analysis of 6 additional cases with whole-genome and transcriptome data showed no statistical correlation between PD-L1 IHC and tobacco-induced hypermutation signature (p=0.22), or PD-L1 mRNA expression (R[2] = 0.35) by linear regression.
PD-L1 IHC is reproducible in the setting of an academic reference laboratory. There are small, but potentially clinically relevant, differences between commercially available PD-L1 diagnostic antibodies. Primary tumor PD-L1 status is generally reflective of metastatic tumor PD-L1 status. Molecular correlates of PD-L1 positive cases remain to be elucidated and warrant further investigation.
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P2.04 - Poster Session/ Biology, Pathology, and Molecular Testing (ID 234)
- Event: WCLC 2015
- Type: Poster
- Track: Biology, Pathology, and Molecular Testing
- Presentations: 1
- Moderators:
- Coordinates: 9/08/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
P2.04-067 - Clinical Characteristics Associated with PDL1 Positive Status in Resected NSCLC (ID 1077)
09:30 - 17:00 | Author(s): S. Zachara-Szczakowski
- Abstract
- Slides
Multiple different PD1 and PDL1 targeting antibodies have been developed for the treatment of NSCLC. Identifying the population most likely to benefit from PD1/PDL1 direct therapy has focused on PDL1 immunohistochemistry (IHC) of the tumor cells. However, each therapeutic agent has a different companion diagnostic test therefore it is difficult to consistently ascertain the PDL1 status of an individual patient. We proposed to evaluate clinical predictors of PDL1 positive status based on consensus PDL1 immunohistochemistry.
Patients with resected Stage II lung adenocarcinoma who underwent adjuvant chemotherapy at the BC Cancer Agency were selected for this study. A tissue microarray (TMA) with matched primary and lymph node was constructed. IHC directed towards PD-L1 was performed with 2 different primary antibody clones: E1L3N (Cell Signaling Technology) and SP142 (Spring Bioscience). PDL1 consensus score was considered positive if there was concordance with both antibodies. Clinical characteristics were abstracted by retrospective chart review.
Eighty cases of NSCLC were identified and used in TMA construction. 19 primary tumors (24%) were PD-L1 positive by consensus scoring. Lymph node metastases showed a concordant PD-L1 score in 92% cases. Patients were categorized as PDL1 positive based on consensus score of the primary tumor. Baseline characteristics based on PDL1 primary tumor status negative/positive: female 64%/47%, median age 61/65 (NS). Current smoker at the time of diagnosis 34%/58% (p=0.07). The 7 EGFR mutation positive and 2 ALK positive patients were PDL1 negative. PDL1 positivity was examined by pack years of smoking: >10 pk yrs 69%/90% (p=0.13), >20 pk yrs 62%/79% (p=0.26), >30 pk yrs 39/63% (p=0.11) and tumor differentiation: well 13%/5%, moderate 48%/21%, poorly 39%/74% (p=0.03).
PDL1 positive status is associated with poorly differentiated tumors and demonstrates a trend towards current smokers. This is consistent with the concept that smoking related malignancies and poorly differentiated tumors are more antigenic and therefore require immunosuppression via PDL1 to remain undetected by the immune system.
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Chop Shop Samples – Tech City Volume.1 (WAV) | 327 MB
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⢠20 Claps and Snares


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Simple tips for tracking progress
When you start using your psoriasis treatment, it is normal to want it to work quickly. It can be frustrating if this doesn't happen and it might make you think your treatment isn't working. However, you should be patient. It may take a few weeks or months before you start to see the effects of some psoriasis treatments.1,2 It is important to continue with your treatment as discussed with your doctor. Stopping your treatment can lead to a flare-up in your symptoms.3
Finding the right treatment can be hard. What works for other people may not work for you. Working with your doctor you should be able to find a treatment plan that works for you.4
Spot the difference
To help you judge whether your treatment is working, try to spot and record even the smallest changes in the way your skin looks and feels.
Rather than relying on sight alone, close your eyes and touch your psoriasis. It may be that you feel the difference in the thickness or roughness of your plaques.1,5
Keep a record
Writing a diary can help keep you on track with your treatment plan.6 Note down what your day was like, how you were feeling and also your diet and whether you had any flare-ups.6 This can help you identify triggers for your psoriasis and will help you notice small improvements you might otherwise have missed.
If you have many plaques, you might not notice gradual improvements in your skin. Including photos in your diary can be useful. Take a photo of your plaques before starting a new treatment and then again at regular intervals during the course of your treatment. This will create a visual record of your condition and may allow you and your doctor to see any benefits of your treatment more clearly.7
Regular reviews
If you have psoriasis you should seek regular review appointments with your healthcare professional - at least once a year.5 In these reviews you could show your doctor the record you have kept of your psoriasis. The record will help them determine if any changes should be made to your treatment plan.
Define your goals
Finally, it is worth thinking about what you want to get out of your treatment. Some people's main goal is to eliminate any signs of their psoriasis that are visible to others. Other people may be more interested in reducing the physical discomfort of their psoriasis. It is important to talk to your healthcare professional about what matters to you most. This can help to find the right treatment for you.8
This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your doctor or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.
UK/IE MAT-26899 Date of prep: July 2019
- www.nhs.uk/conditions/psoriasis/treatment/ (accessed July 2019).
- www.psoriasis.org/about-psoriasis/treatments/systemics/soriatane/ (accessed July 2019).
- NICE guidance. Psoriasis assessment and management. 2012.
- www.psoriasis.org/about-psoriasis/treatments (accessed July 2019).
- SIGN. Treating psoriasis and psoriatic arthritis. 2012.
- www.everydayhealth.com/psoriasis/treatment/tracking-psoriasis-symptoms (accessed July 2019).
- www.sharecare.com/health/psoriasis-skin/article/tracking-your-psoriasis-triggers (accessed July 2019).
- A Tuckman. Dermatol Ther 2017; 7(Suppl1): S53-7


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Make an Appointment
To make an appointment: Please call one of our offices.
If you have any questions regarding your diagnosis or treatment, or office policy and procedure, please feel free to call.
All calls will be returned during our normal business hours.
Saratoga Springs Office
Phone: 518-587-7746
31 Myrtle Street
Saratoga Springs, NY 12866
Glens Falls Office
Phone: 518-743-1010
7 Murray St.
Glens Falls, NY 12801
Plattsburg Office
Phone: 518-306-7255
16 DeGrandpre Way, Suite 100
Plattsburgh, NY 12901
If you are a new patient, for your convenience, you may download our new patient forms to bring with you.


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Geometric Lines – Red Ginger, Chrysanthemum & Typha Leaves
The clean lines in this floral arrangement was very eye catching! The trick was to create two separate and distinct set of lines using the typha leaves. Using foliage to create space and shapes could lead to very interesting designs.
The pop of colour from the red ginger with its interesting texture also gives the floral arrangement another focal point.


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What Is Gambling? Any wagering or betting for self or others…
What Is Gambling?
Any wagering or betting for self or others whether for loan or not and where the result is unsure or depends on possibility or likelihood makes up gaming. Betting comes in lots of types.
There is something called as compulsive gaming. It begins at the age of 20's for the majority of guys and at the late 30's for ladies as an amusing, tension eliminating and enjoyable activity which ultimately advances to end up being a regular gaming. Regardless of interruptions in household and expert life, the gaming goes on.
Compulsive gaming has 3 stages which consist of euphoria when winning, serious stress and anxiety when losing and severe stress and anxiety in between these 2 stages. Being a gaming addict not just triggers difficulty to the private however likewise to the individuals around the person. Gaming is constantly associated with physical signs like stress and anxiety, headaches, and anxiety leading to cigarette smoking and alcohol usage.
As it advances, the specific losses the task and the cost savings may be lost which might cause the specific to endeavor in criminal activities like taking loan from coworkers to acquire more funds for gaming. They likewise obtain big quantity of cash which is typically never ever be paid. They tend to neglect leas and other household expenditures.
Since of the simple gain access to and schedule of gambling establishments, heavy betting is done. People from the middle class household are more susceptible to betting since of the joblessness.
What is drug dependency?
Drug dependency is most likely understood as the imbalance state of an individual resulting in inappropriate performance of both his body and mind.
nicotine and so on,
Sedatives and Hypnotics Which Includes
clonazepam, temazepam
Methaqualone and the associated quinazolinone
Opiate and Opioid Analgesics Which Consists of
Morphine and Codeine
Semi-synthetic opiates such as Heroin
( Diacetylmorphine), Oxycodone, and Hydromorphone
What Is Marijuana?
Cannabis is a type of drug. It is a mix of different parts (leaves, stems, flowers and seeds) of a plant called the hemp plant. Cannabis has about 400 various types of chemical in it and some of them can trigger cancer, however the active and primary component is called as tetrahydrocannabinol which is much better understood as THC.
Cannabis is utilized in various methods. Some of users blend it with food, some brew it as tea however many of them smoke.
In olden days individuals choose to take tobacco, alcohol, heroine and so on, as a drug to nurture them. Nowadays it is casual to nurture them by utilizing particular drug injections which is an immediate procedure and likewise more efficient. There are lots of options it appears to be the time conserving technique.
Alcohol addiction
What do you suggest by the term alcohol addiction?
Individuals are stating lots of factors for the consumption of this sluggish toxin, despite of the health issues and unfavorable social series made by it. Some individuals state that the unexpected stop of specific alcoholic drinks will lead to a terrific issue in health.
Nowadays there are numerous modern-day medical diagnoses taken versus the drug dependency through utilizing contemporary innovations. It is possible to identify an individual by understanding the consumption of that specific drug.
In European nations they are having a hard time to reduce individuals who were impacted by drug dependency, however it is rather hard there. On other hand in USA they have actually accomplished.
What are the results of cannabis and other drugs?
When the drug goes into the brain, the THC present in it finds the nerve cells with particular receptors called cannabinoid receptors and binds to them. High use of the drug can trigger stress and anxiety and typically panic attacks.
When the THC binds to these parts it triggers studying and memory issues like remembering the current occasions ending up being tough. And another part of the brain called basal ganglia is likewise impacted by THC. It is risky to drive lorries when cannabis is utilized or it might lead to mishap.
Cigarette smoking Marijuana increases the opportunity of cardiac arrest. It might likewise result in lung cancer even rapidly than typical smoking since the Marijuana cigarette smoker tends to breathe in more deeply and hold his breath longer than a cigarette smoker does.
What are the alternative treatments offered for drug dependency?
A few of the medical specialists state that acupuncture is among the excellent option treatments for such dependency. There is some info about some alternative treatment, you can ask to understand which one is appropriate to you.
What do you understand about self medication?
Self medication called as the treatment which is produced us and made by us with no medical guidance. Then it is reasonable to discuss it as self medication, if a purchaser identifies himself utilizing particular drug.
Due to the fact that you might utilize the drug on incorrect ratio which leads to any other issues, it is not suggested to carry out self medication. We need to make sure about the nature and usage of that drug.
Lots of posts state about these drug dependencies and its rehab, it is not recommended to take specific drugs which leads to deadly outcomes. It is much better to conclude this essay by stating "avoidance is much better than remedy".
What is the treatment?
When addicted, it will be extremely tough to come out. The user should have pure decision to eliminate these drugs.
Does Marijuana have medical worths?
Cannabis has medical worths. THC, the active and primary active ingredient can produce impacts which can be possibly utilized for dealing with range of medical conditions.
Drug dependency is most likely understood as the imbalance state of an individual resulting in incorrect performance of both his body and mind. Cannabis is a type of drug. Nowadays it is casual to nurture them by utilizing particular drug injections which is an immediate procedure and likewise more efficient. Nowadays there are numerous modern-day medical diagnoses taken versus the drug dependency through utilizing contemporary innovations. Lots of short articles state about these drug dependencies and its rehab, it is not a good idea to take specific drugs which leads to deadly outcomes.


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News & Media
Welcome to The Daily Mile's News & Media Hub – here you will find news articles, videos and case studies completed by Daily Mile schools.
In the NewsVIEW ALL NEWS
Press Release: The Daily Mile founder awarded MBE in New Year Honours List31st December 2018
Press Release: Hit Children's Fitness Initiative Receives £1.5 Million Boost in biggest step taken to reach all schools in England17th December 2018
Over 13,000 Suffolk primary school children now benefitting from Daily Mile campaign14th December 2018
Sugar tax pays for running tracks13th December 2018
Press Release: The Daily Mile comes home to Scotland as children run at halftime at Murrayfield23rd November 2018
Press Release: Dr Rosena Allin-Khan MP launches The Daily Mile in Tooting22nd November 2018
Case studiesVIEW ALL CASE STUDIES
Listellick National School – Co. Kerry, Ireland25th April 2018
Listellick National School Fact File Where we're based: Listellick, Tralee, County Kerry, Ireland School Roll: 224 How many pupils take part in The Daily Mile: 224 Month/Year we started The Daily mile: November, 2017 Where do we do The Daily Mile? In our school playgrounds A brief description of your school? Our schol is an […]
St Brendan's N.S. – Co. Kerry, Ireland12th April 2018
St Brendan's N.S. Fact File Where we're based: Blennerville, Tralee in Republic of Ireland School roll: 181 students Month/Year we started The Daily Mile: October 2017 Mr Terry O'Sullivan, Principal, talks us through St. Brendan N.S. Primary School's experience of The Daily Mile, thus far. The Daily Mile initiative in our school has been supported […]


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Columbia, SC
Founded: 1994
Tel: (803) 744-0841
Website: http://www.godspeedresources.org
Top Leader: Mr. Curtis McGown
Donor Contact: Ms. Carey Hargis
Member Since: October 29, 2012
Godspeed Resources Connection (GRC) is a faith-based organization dedicated to enabling global workers to thrive! We exclusively serve those sent cross-culturally by providing preventative and restorative care to strengthen their well-being in life and work. We develop emotional, relational, and spiritual health in our clients through debriefing, spiritual direction, counseling, psychiatric care, check ups, and consulting. Our clients include individual global workers and families and their organizations. Delivery of services occur in person in our Columbia, SC office and on-site throughout Indonesia, as well as, online anywhere there is an internet connection overseas.


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Ishikari Shinko New Energy Hatsuden GK will build a biomass power plant in Ishikari City, Hokkaido, Japan.
Ishikari Shinko New Energy Hatsuden (Sapporo City) is a wholly-owned subsidiary of Okumura Corp (midsize general contractor). It had a ceremony to pray for safe construction of the plant and a ground-breaking ceremony Oct 7, 2019, aiming to start operation of the plant in August 2022.
The woody biomass power plant will have an output of 51.5MW (grid capacity: 45MW) and is expected to generate 360,000,000kWh of electricity, which is equivalent to the amount consumed by 121,000 households, per year. The FIT tariff set for the plant is ¥24/kWh.


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Membership: Restricted States
$ 30.00
Membership: Restricted States - Do you reside in a State that restricts the shipment of ammunition? Residents of CA, CT, IL, MA, NJ or NY can still get members-only discounts from Bone Frog Gun Club by purchasing a Membership! Please note we will still require valid credentials for membership if you reside in a restricted State; credentials will be verified before you can order at member prices.
The Annual Membership fee will be waived for Veterans, Active-Duty Military, First Responders and Law Enforcement (current/retired). Please see our Lifetime Membership registration page if you qualify.
Membership Benefits:
Exclusive, members pricing (up to 30% off)
A free gift on sign-up
$30 / year.
You are not required to purchase a membership. Account holders who are not MEMBERS may still shop with us at our standard, retail prices, but will not receive members-only pricing and deals.
Members must be logged in to view member pricing.
Please note we will still require valid credentials for members residing in restricted states and we will review your submission before approval. Once approved, you will receive an email from us. Check your junk mail/spam folder because the account activation emails are often filtered there.
States which restrict the sale of ammunition:
If you reside in a State which restricts the sale of ammunition, we require you to register with us BEFORE ordering. Please fill out this form if you live in the States of CA, CT, IL, MA, NY, NJ or if you are registering as a Licensed Ammunition Vendor. We do our best to review the information and approve accounts within 48 hours. Submissions that are sent on weekends may require additional time for review. Once your account has been activated, your account will remain active for as long as your credentials remain valid. Upon expiration of your credentials, you must resubmit updated information. Please refer to our Restricted States page for more detailed information. Once registered with us, you will be able to purchase all products on our store. You will receive an email once your account is activated. Please check your junk mail/spam folder because the account activation emails are often filtered there.
FFL Holders
Your shipping address must match the address on your FFL Certificate.


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Contact Supplier
Ms. Olive HeLeave a message
|Unit Price:
|USD 80 / Pair
|Payment Type:
|Min. Order:
|10 Pair
|Delivery Time:
|10 Days
Basic Info
Model No.: OEMFB03
Brand: Other
Applicable Gender: Men
Gear: Other
Wheel Size: Other
Foldable: Not Foldable
Frame Material: Steel
Color: Green
Fork: Steel
Tire: 650C*25C
Additional Info
Packaging: 1 pair per box
Productivity: 1200PCS PER Month
Brand: OEM
Transportation: Ocean,Land,Air,air express
Place of Origin: China Mainland
Supply Ability: 1200PCS PER Month
Port: NINGBO,SHANGHAI,TIANJI
Product Description
Detail Image
Other Product
Company Information
Our Product Range
style: Fixed Gear Bike, Road Bike , Chopper Bike, Mountain Bike,beach
cruiser bike,Freestyle Bike,Folding Bike,Tandem Bike ,gasoline bike,
City Bike , Kids Bike, BMX, Unicycle and parts.
1.Sample: samples can be offered
2.Wholesale: you can order in a small quantity and can mix
3.Quick delivery time: about ONE week after your payment
4.Payment: 100% paid by T/T or PayPal
Product Categories : Fixed Gear Bike > Hi-ten Fixed Gear Bike
Hot Products


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Upcoming Events and More. Get It Here.
https://i1.wp.com/shellylouslids.com/wp-content/uploads/2019/02/shelly-lous-lids-sewing.jpg?fit=1200%2C800&ssl=1 800 1200 DesignRefinery https://shellylouslids.com/wp-content/uploads/2019/01/Shelly-Lous-Lids-Logo-Final_03.png DesignRefinery2019-02-08 11:04:222019-03-15 10:40:35Shelly Lou's February News!
/0 Comments/by DesignRefinery
The BIG NEWS- I'm getting myself and my hats out of the house THIS SATURDAY and we are headed to the Grove City Brewing Co for Shelly Lou's Valentine's Sip & Shop. 10 of my favorite handmade brands will be set up with me. You'll find all kinds of unique items for your Valentine (or YOURSELF) […]


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Diane Rothman is the owner of The Sacred Sage, a Metaphysical shop in Farmington Michigan. She's also the Founder of The Church of the Human Spirit. Diane had so many wonderful things to share and discuss during the episode. Her Spiritual journey has led her to not only opening The Sacred Sage but also exploring the realm of Spirituality on a much deeper level. She shared her experience as a Certified Healing Touch practitioner and instructor. Diane also Channels an entity named "Pinky", which we discuss at great length during the interview. Enjoy!
Sacred Sage Website- http://thesacredsage.com/index.html
The Church of the Human Spirit Website- http://www.churchofthehumanspirit.org/
Sacred Sage on Facebook- https://www.facebook.com/TheSacredSage/


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Casino BlogStay connected for latest News,Blogs and Feeds
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2Can, 5 Dragons, 50 Lions and Big Ben, 4 of the Top Microgaming Pokies
New Zealand's most popular pokie machine games are a product of the giants Aristocrat Technologies and if we go by the reception that the Aristocrat pokies have received in the market, we would come to a decisive conclusion that they something worth checking. Aristocrat Technologies is a gaming company that has been in the industry for many years and this explains why they usually regarded as the best in the line of pokies online. Another unique feature about Aristocrat pokies is that they embrace the use of high technology.
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In this pokies, the Aristocrat are credited for the efforts that they put in place to ensure that it scores highly is all the key areas. It is a five-reel game that is accompanied with 25 paylines meaning that the pokie has quite a good number of multipliers, wild symbols and scatter symbols. You can also get free spin bonus which can go up to 20 free spins. When it comes to graphics, Aristocrat is credited for delivering high quality graphics that is characterized by real realistic audio-visio interaction. In the pokies, you will interact with amazing casts such as the blue tree frogs, leopards, monkeys, iguanas, butterflies and many others.
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This is a free Aristocrat pokies that gives players rare chances of experiencing luck of the dragons. It has been specially designed for New Zealand pokies fans. The pokies has 25 paylines which are accompanied by 243 different ways to win feature, something that is very popular among many popular online pokies . The jackpot payout can go to as high as 3200 credits and if you are a fan of the Japanese music, you will enjoy some from the game. The graphics are also fine and have been polished to match the game's theme. You are also likely to learn more about Japanese culture.
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Rounding up accomplices desperate to absolve themselves from debts and financial hardship, Tew Yee Jeng, a 40-year-old Malaysian, made several trips to Singapore between 2012 and 2014, where he would orchestrate scam traffic accidents to make insurance claims for property damage and bodily injuries. The drivers he recruited would abruptly slam their brakes on purpose, leading to collisions with vehicles behind them that could not be stopped in time to prevent a crash.
Tag: motor claim
Motor Insurance Claim Handling Process
I like this article that was written by one Ms Lim Ka Ea, on her recent experience trying to understand how the motor claims handling process works…. You can view it over at the malaysian insider. I can understand her…