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Order Form | Credit Application
Note: You can use Adobe Acrobat Reader to open the form. If you do not access to Adobe Acrobat Reader, you can download it now.
To access the order form, simply click on the button below.
To print the credit application form when you are in the open form, go to taskbar at the top of the page, click File, then Print and then OK in the window open print. So, you print the application credit.
You can return the form duly signed and completed, by fax or mail to Thermoform as indicated below.
Mail:970, rue Théophile-Saint-Laurent, Nicolet (Québec) J3T 1B4
819 293-4110


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Nos reunimos un año más con Celia Pulido, responsable del departamento de eventos de Albir Playa Hotel & Spa y organizadora de Enlázate, feria de bodas que celebra su 3ª edición en las instalaciones del hotel, los días 25 y 26 de noviembre de 2017. ...Leer mas »
Photography, the art of image
Audrey Lohkamp was born in Germany in 1991. Since she was 10 years old, she has been passionate about photography. Her beginnings in this world were really peculiar. Her father gave her a camera for her 10th birthday. She did not show any interest for this matter before, buy this ...Leer mas »
The Raconet of the Dansa
Her name is Eva Rodríguez Olmos, and she is the owner of a dancing clothes and complements store: El Raconet de la Dansa, located in Alfás del Pi, Ejércitos españoles street, 66, in front of the House of Culture. Eva, tell us about what led you to open your store. ...Leer mas »
7 tips for your Christmas decoration
The best way to welcome Christmas is to begin with your homes. Filling your homes with that incomparable celebration spirit, and every corner with the ornaments that suit the occasion is an important component of the celebration. Main entry The main entry is the best letter of recommendation of every ...Leer mas »
Sandos Mónaco improves its category to superior 4 star hotel
This Spanish chain of hotels works to improve their facilities, and now bets for new themes, and concepts like hotels for adults. Sandos Mónaco Beach Hotel & Spa from Benidorm has recently improved its category to a superior 4 stars hotel. This recognizes the excellent work done by the hotel ...Leer mas »
En Together cuidamos y mimamos a las mascotas
Diego Fernando Arboleda, a young Colombian entrepreneur, created and opened his own business thinking of his pet. How would you define your business Diego? For me, the concept is based on inclusion. A pet has to be a part, a member of the family, has to go with you everywhere ...Leer mas »
Interview with Celia Pulido
Celia Pulido, Albir Playa Hotel & Spa Events responsible Enlázate, 2016, is the new edition of one wedding fair in which more than 100 professionals of the sector participate. Celia Pulido, responsible of events of this hotel, tells us some information about a fair that has become a referent within ...Leer mas »
With the arrival of a new academic year, lots of happy moments are around the corner for our children. The really expected re-encounter with their beloved friends and teachers arrives. However, for some kids, this return means the beginning of a nightmare: bullying. Bullying is defined as: school harassment and ...Leer mas »
Complements and accessories to look always in fashion
The world of fashion offers us an unlimited variety of options to combine with our personal likes. The complements and accessories play an important role due to they provide our outfits with a lot more life and elegance. When it comes the time to choose them, you should take into ...Leer mas »
¿Quién es Victoria Secret? ¿Cuál es su secreto?
Who is Victoria Secret? What is her secret? Nowadays, Victoria´s Secret is one of the most recognized and famous fashion brands. Its great virtuosity and sensuality are its most valuable attributes. Victoria´s Secret was created in San Francisco in 1977 thanks to the shyness of a man, Roy Ramond, who ...Leer mas »

subset: commoncrawl


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Glandular fever is an infection usually caused by the Epstein-Barr virus.
Gladular fever spreads through saliva, which is why it is sometimes called "kissing disease."
- Infection can occur at any age, but is most commonly seen in 15 to 17-year olds.
- Symptoms can include fever, sore throat, sore glands and tiredness which last a few days to few weeks.
- Not everyone gets symptoms and many people have had it at some time, without knowing.
SymptomsThese can include:
- flu like symptoms such as fever and headache
- sore throat (often with white stuff on your tonsils)
- swollen lymph glands (such as in your neck)
- feeling generally unwell, joint pains
- tiredness, and loss of appetite.
If you have a sore throat and fever that has lasted for more than a few days, you should see your doctor/nurse for advice. If the symptoms and signs are typical, the diagnosis can be made based on your history and examination. If your doctor isn't so sure you may be asked to have a blood test to help confirm the diagnosis.
Treatment focuses on reducing symptoms and includes:
- medicines for pain and fever eg paracetamol or ibuprofen
- warm salt water gargles
- plenty of rest and fluids
- gradually increasing activity levels as you are able to.
What to expect
Most people get better in two to four weeks. However, it can cause tiredness and loss of energy for a longer period – even up to a few months.
- You can return to work, college or school as soon as you feel well enough.
- There is little risk of spreading the infection to others as long as you follow common sense precautions, such as not kissing other people or sharing utensils.
- You should avoid contact sports or activities that put you at risk of falling is because if you have a swollen spleen, a sudden knock could cause it to rupture.
- You also need to avoid alcohol as this could damage your liver, which is often affected by the infection.
NOTE: complete bed rest is no longer recommended, as it can make the symptoms of fatigue last longer.
If you think you or a family member may have glandular fever, you should see your doctor. This is important as there can be complications that can occur. These include:
- swollen or ruptured spleen, (rupture 1 in 1000, usually result of contact sport)
- neurological, (1 in 100)
- blood cells
- secondary infection
- prolonged fatigue (1 in 10)
- hepatitis
Self care
If you develop glandular fever, you should avoid kissing and sharing eating and drinking utensils for at least two months after your symptoms begin.
You also need to take extra care with washing your hands regularly, particularly after coughing or sneezing.
You do not need to be isolated from others, because most people will already be immune to the Epstein-Barr virus.
Learn more
The UK based NHS website has a useful section on glandular fever


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Laboratory practice is essential to get deep understanding of theoretical concepts with clarity. Department of Automobile Engineering is well equipped with laboratories like
• Automobile Engine
• Automobile Systems
• Automobile Electrical System
• Vehicle Maintenance and Garage Practice
• Material Science and Metallurgy
• Mechanical Measurement and Metrology
• Fluid Mechanics
• Dynamics of Machines
• Heat Transfer
• Refrigeration and Air Conditioning
• CAD/CAM Lab
Our Automobile Engine lab is well equipped with the 3 Cylinder Petrol Engine and 4 Cylinder Diesel Engine with an Eddy Current Dynamometer to perform practicals of Heat balance Sheet, Morse Test and Performance test on it. Through this testing facility, students are gaining enormous knowledge regarding performance of engine and functions of each of its component. Also they are able to know difference in the performance of both petrol and diesel engine.
Our Vehicle Maintenance and Garage Practice lab is currently equipped with
• 3D Wheel Alignment and Balancing Machine
• Tyre changer and
• Fuel Injector cleaner.
The above mentioned equipments are also used for commercial services. By hands on practice, students are going to learn how to use different testing equipments which they have studied theoretically.
Other integrated facilities included in Automobile Systems and Automobile Electrical System labs are
• Working model of motorized 4 cylinder 4 stroke S.I. Engine
• Sliding mesh and Synchromesh Gear Box
• Various types of Clutches
• Electrical Wiring System of a vehicle
• Cut section models of Single Cylinder 2 Stroke Petrol Engine for plotting port timing diagram
• Single Cylinder 4 Stroke Petrol and Diesel Engines for plotting valve timing diagram
• Various types Brake System
• Differential Rear Axle
• Various types Suspension System
• Steering Gears
• Power Steering
• Torque Converter and Automatic transmission to practice real time which is offering the clarity of understanding about function of various systems of automobile.
Other equipments we have include
• Multicylinder Engines with Dynamometers
• Ultrasonic Testing facility, Profile Projector
• Tool makers Microscope
• Surface Roughness Tester
• Universal Vibration Apparatus
• Cascade Refrigeration System
• CNC Milling Trainer,
• 3D-Printer


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This year's Annual Conference is approaching fast! Register today!
Use promo code BookSavings at checkout for 5% off all publications.
Meet Liam Duffield – Versaton Australia's IT Team Leader by day, adventurer by night.
Take your association with you on the go using our mobile-friendly website.
Launched in 2017, the Virtual Microscopy Database (VMD) is a centralized repository where a community of anatomy and histology scholars and researchers can share a large selection of virtual tissue slides for enhancing education, research, and scholarship. Learn more about the VMD.
The VMD is a free resource to members and nonmembers! As of November 2019, more than 1,100 VMD users hail from 84 different countries on six continents. Apply for your own VMD subscription.
The VMD is home to more than 3,500 virtual histology and pathology images in more than 20 collections! Interested donors may submit digital tissue slides for inclusion in the VMD.
Get occasional updates on the VMD. Follow @VMDatabase.


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Last updated: April 19, 2019 - 12:37 pm
Product Name: Nestlé Nesquik Chocolate Drink Mix, 2.6 lbs.
About This Item
NESQUIKChocolate Powder turns milk into an irresistibly delicious and nutritious drink for your family to enjoy and for you to feel good about, with 45% less sugar than the leading syrup brand. NESQUIKChocolate Powder provides calcium, 8 grams of protein, and 7 essential vitamins and minerals when combined with low-fat milk to help them start the day.
NESQUIK Chocolate Powder has 45% Less Sugar than the leading syrup brand. (11g vs. 20g sugar/svg. 23g total sugar when mixed with 1 cup of low fat milk.)
A good source of 7 essential vitamins and minerals.
>8 grams of protein when combined with low-fat milk.
No Artificial Colors or Flavors. Added Color from Natural Sources
No High Fructose Corn Syrup.
99.9% Caffeine Free. Kosher.
NESQUIK Powder is also available in delicious strawberry flavor.


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Jeff wilson provides housing solution with modular kasita living units. Apr 02, 2017 jeff wilson provides housing solution with modular kasita living units former professor/ current micro housing ceo jeff wilson and his team at kasita have developed a modular, versatile, and transportable living unit self titled- kasita. the idea for the project came about after he spent an entire year living in a 33 ft2 dumpster to experiment with the possibilities and challenges of living in an extremely constricted space and come up with solutions to increase its functionality without compromising comfort. the modular pods measuring roughly 31′ x 12′ can be fitted to serve almost any function- home, workspace, pop-up commercial space – and can be installed almost anywhere and on any terrain. the project provides a sustainable, cost and space efficient solution for a growing population and changing lifestyles. the concept could exist in just about any context around the worldimage by kasita (also first images) image by kasita image by kasita floor planimage by kasita Save.
Small Space Luxury: Three Modern Apartments Under 40 Square Metres That Ooze Class. Like Architecture & Interior Design?
Follow Us... Many people view small apartments with apprehension, thinking that they won't have enough space to fully unleash their design aspirations. But small doesn't have to mean cramped or limited. Small apartments are especially ideal for young couples who are just starting out in the world. VTN architects vertically stacks gardens inside binh house in vietnam. Apr 11, 2017 VTN architects vertically stacks gardens inside binh house in vietnam part of VTN architects' 'house for trees' series, the 'binh house' demonstrates their approach of integrating tropical gardens, open spaces and water within a high density neighborhood in vietnam. the dwelling is occupied by a family of three generations. therefore, the challenge was to establish a home that will give each inhabitant their own space, while encouraging interaction. all images © hiroyuki oki VTN architects (previously vo trong nghia architects) has gained recognition for their green-filled architecture and 'binh house' follows suit. a vertical stacking has been applied to the building, with the gardens and glass walls being sandwiched in-between the two main concrete walls. this strategy not only improves the microclimate by introducing natural ventilation and daylight into every room, but the alternating openings increase visibility and interaction between the family members.
Relaxing Color Schemes In 3 Efficient Single-Bedroom Apartments [With Floor Plans] Like Architecture & Interior Design?
Follow Us... Balancing efficiency with comfort is a constant challenge for designers – but these three single bedroom apartments serve as inspiring examples of success. Each one focuses on organization and openness as a first priority without sacrificing that all important sense of "home" thanks to their warm and welcoming natural neutral color schemes.
You'll also find ideas for storage and organization, streamlined furniture designs, minimalist decor motifs, and each apartment tour even includes a floor plan to help you visualize how the entire home comes together. An Upscale Ukrainian Apartment for the Classy Homeowner. Like Architecture & Interior Design?
Follow Us... Classic and timeless. These seem like two opposite concepts. Lines design reveals urban garden through mesh screen of cube house. Apr 19, 2017 lines design reveals urban garden through mesh screen of cube house 'the cube house' is a residential proposal by multidisciplinary firm: lines design creation and consultancy based in kuwait. the most distinctive feature of the project came from the challenge of incorporating an urban garden as part of the exterior into the courtyard within the scheme.
4 Bright Studio Apartments With Creative Bedroom Placement. Like Architecture & Interior Design?
Follow Us... Deciding how to handle the sleeping situation is one of the most challenging aspects of designing a studio apartment, requiring a lot of forethought to match the lifestyle preferences of the resident while working around any architectural or floor plan obstacles that can limit the available options. And that's even before taking decor into consideration! Delution architect hosts music and ballet studios inside the equalizer in indonesia. Apr 25, 2017 delution architect hosts music and ballet studios inside the equalizer in indonesia a production house, a music and ballet studio resides inside this red brick building called 'the equalizer' in bekasi, indonesia. music and rhythm were the main concepts that drove the organization of the scheme with the building mass divided into two parts; the juxtaposition of the high and lower volumes symbolic to the movement of a conductor's hand. all images © fernando gomulya delution architects used minimal glass to keep each of the internal spaces impermeable and less of a chance of leaking sound. the volumes create an area of shade and space for parking meanwhile, the studios and working spaces can be found on the first floors, and the 2nd and 3rd used for meeting rooms and outdoor areas integrated with greenery. the space in-between the two brick volumes are used as access routes and is shaped like a T to encourages a triple cross ventilation effect. the music studio concept.
3 Modern Studio Apartments With Glass-Walled Bedrooms. Like Architecture & Interior Design?
Follow Us... While some studio floor plans can accommodate bedroom privacy without the need for additional curtains or screens, this post looks at apartments that required a different approach. Each of these compact apartments separate the bedroom from the rest of the space with attractive glass walls – a lightweight solution that dampens unwanted noise and creates physical boundaries without looking too "closed off". If you're looking for ways to isolate the bedroom without disrupting the visual flow of your home, check out these three gorgeous apartments below. At 45 square meters in size, this compact apartment doesn't have much space to create a separate environment for each room – thankfully, the designers were able to use features like sliding curtains and frosted glass doors as flexible partitions where needed.
The decor is restrained but avoids full minimalism. Single Bedroom Apartments That Are Perfect For The Single Life [Includes Floor Plans] Like Architecture & Interior Design?
Follow Us... The single life is one of the best ways to live. You're the only person you have to take care of, and your space is all your own. Vincent parreira converts photography studio into apartments. In paris, architect vincent parreira has converted a 19th century photography studio into a pair of rooftop apartments. conceived as an 'inhabited observatory', the residences are situated at the top of an haussmannian building in the city's opéra-madeleine district. the two contiguous duplex apartments have been configured for short term rental use, with bedrooms and bathrooms on the lower levels and the reception area, with its drawing room and kitchen, on the storey above. the building's original glass roof has been completely replaced image © luc boegly (also main image) the rooftop residence has been conceived as an 'inhabited observatory' image © luc boegly built-in elements of furniture leave the space free of superfluous elements image © luc boegly 'the bedroom is placed behind a transparent glass wall,' explains the architect.
3 Fabulous Apartment Designs With Lofted Bedrooms. Like Architecture & Interior Design? Follow Us... Lofts are a versatile solution to a number of complicated interior design problems. In small apartments, they can expand usable space while putting vertical real estate to good use. Stu/D/O carves openings throughout the façade of bangkok house. Standing at four-storeys with rectangular masses and openings carved out from the vertical volume is the 'aperture house' in bangkok, thailand. residing the dwelling is a photographer and a landscape designer and taking cues from their occupations, Stu/D/O responded with a design that merges greenery and carefully arranged openings that display full-framed views of the surrounding vistas. all images © ketsiree wongwan / chaichoompol vathakanon aperture house captures the turnings of time through the interplay of lights and shadows, as daylight cascade through the architectural facade and openings. the largest void reveals an expansive vertical space, and becomes the main focal point the house.
5 Studio Apartments that Use Space Splendidly. Like Architecture & Interior Design? Follow Us... Living in a studio apartment is perhaps no one's dream. But for the urban professional or studio, it may be nearly impossible to find a place that is both affordable and spacious. A Compact Apartment in Kiev with a Glass-Enclosed Bedroom. Spanning a mere 45 square meters (approx. 484 square feet), this compact apartment in the center of Kiev was designed by MARTIN architects for clients who were looking to use it as a rental property.
Their requirements were for the space to be functional while also visually appealing to the masses that might seek to rent it out. While each necessary function gets its own designated place within the apartment, the open layout keeps it light and open so it appears larger. The bedroom was partitioned off with framed glass so light still passes thought while also offering the space privacy when the curtains are closed. The palette was kept fairly neutral with gray, black, and brown being the primary colors, while a blue/green was brought in for the accent color. The kitchen wall was outfitted with brick that was painted black to contrast the light wood floors. Studio MM Architect, TinkerBox - Modern Architect, Residential Design - NYC, Hudson Valley. 5 Beautiful Studio Apartments. 3 Small Studio Apartments That Exude Luxurious Space.
Transformers: 2 Beijing Houses Packed Full of Space-Maximizing Tricks. Think you've seen it all when it comes to ideas for saving space in small houses and apartments? Beijing's B.L.U.E. Architecture Studio is here to prove you wrong in the most delightful way, with a series of transforming elements and incredibly clever layouts in two tiny 'hutong' alley houses. 5 Innovative Apartment Designs That Make Small Areas Sing. Super Small Studio Apartment Under 50 Square Meters (Includes Floor Plan)
3 Small Apartments That Rock Uncommon Color Schemes [With Floor Plans] Vo trong nghia stacks terracotta brick façade for panasonic showroom. Nov 16, 2016 vo trong nghia stacks terracotta brick façade for panasonic showroom vietnamese firm vo trong nghia architects has shared their design of a gallery and showroom for panasonic. the vertical site located in the dong da district, hanoi features a seamless envelope constructed entirely from terracotta bricks displaying a floral pattern. images © hiroyuki oki / trieu chien.
4 Single Studio Apartment Designs under 100 Square Metres. Maximize Minimal Space With Robotic Furniture. The influx of young professionals into competitive markets like San Francisco, London, Seattle, New York City, and Los Angeles has led to a dearth of available housing accompanied with increasingly prohibitively expensive rents. Bold Decor In Small Spaces: 3 Homes Under 50 Square Meters. Four Small Studios That Explore Fun and Whimsical Styles. Two Takes On The Same Super-Small Apartment. An Industrial Loft in The Netherlands. A Modern Parisian Flat Atop a Department Store. 5 Small Studio Apartments With Beautiful Design. A Gorgeous Home Split By A Covered Garden Atrium. 4 Small Apartments Showcase The Flexibility Of Compact Design. 25 Stunning Bedroom Lighting Ideas.
5 Ideas For A One Bedroom Apartment With Study (Includes Floor Plans) 3 Luxury Homes Taking Different Approaches To Wall Art. Red and Blue: Two Colorful Apartments Under 75 Square Meters. 4 Super Tiny Apartments Under 30 Square Meters [Includes Floor Plans] Small Budapest Apartment Designed for Travelers. 4 Beautiful Dark Themed Homes. 3 Inspiring Homes With Concrete Ceilings and Wood Floors. 6 Beautiful Home Designs Under 30 Square Meters [With Floor Plans] Chic Scandinavian Loft Interior. Ultra Tiny Home Design: 4 Interiors Under 40 Square Meters. 40 More 1 Bedroom Home Floor Plans. 40 More 2 Bedroom Home Floor Plans. Small, Smart Studios with Slick, Simple Designs. Small, Smart Studios with Slick, Simple Designs.
4 Small Studio Apartments Decorated in 4 Different Styles. Apartment Designs For A Small Family, Young Couple And A Bachelor. Garage converted into apartment. A Super Small Apartment That Adapts To Its Owner's Needs. 3 Creative Top Floor Rooms with Wood Accents. 2 Creative Apartments Featuring Whimsical Art. 25 One Bedroom House/Apartment Plans. Minimalist 1 Bedroom Apartment Designed For A Young Man. Aviation Inspiration and Superhero Dreams in a Quirky Tainan Home. 25 Two Bedroom House/Apartment Floor Plans. Eclectic Single Bedroom Apartment With Open Floor Plan. 2 Super Small Apartments Under 30 Square Meters. Stylish St. Petersburg Apartment for an Artistic Professional Couple. Small house design for single people. Small Apartment Interior Design: Working With Just 40 Square Meter (431 Square Feet) 2 Simple, Super Beautiful Studio Apartment Concepts For A Young Couple [Includes Floor Plans] 3 Beautiful Homes Under 500 Square Feet.
Studio Apartment Floor Plans. Homes Under 400 Square Feet: 5 Apartments That Squeeze Utility Out Of Every Square Inch. 1 Bedroom Apartment/House Plans.


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Majestic Photographs of Zoo Animals by Manuela Kulpa
Photographer Manuela Kulpa takes the most majestic photographs of zoo animals you have ever seen.
Taking pictures in zoo's and wildlife parks, each photo captures an attentive & beautiful look into the lives of the animals she photographs, including lions, giraffes, tigers and monkeys. Each photograph is treated to a unique processing stage that can take weeks to complete.
The results however speak for themselves. Check out plenty more photographs by Kulpa over on 500px.
source: Facebook


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Field of Study
Game design and development involves the creation of video games, a topic residing primarily in the domain of computer science, with some coverage of digital arts.
Material Covered
This course is an introductory overview of video game design and development and the fundamentals of the game industry. Topics include a brief history of video games, the elements that define a video game, content creation strategies, the design and development process, industry professions, and game design and development techniques.
Student Expectations
Students will design and develop their own original games by using MIT's free Scratch web application and Unity, free software that is used widely by game industry professionals.
Additional Information
Girls and boys of all backgrounds are encouraged to take Intro to Game Design and Development. Students will understand the value of diversity in the video game industry and will gain a strong foundation to pursue further study in game design, game development, or related studies in computer science or digital arts.
- Pre-Algebra
- Prior programming knowledge is not required
Course Texts and Materials
- No textbook is required for this course.
- Scratch is a free, web-based application. Visit scratch.mit.edu/info/faq for system requirements.
- Unity Personal is a free application that may be downloaded for Windows, Mac, and Linux. Visit unity3d.com/unity/system-requirements for system requirements.


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Longevity Meme Newsletter, August 17 2009
August 17 2009
The Longevity Meme Newsletter is a weekly e-mail containing news, opinions, and happenings for people interested in healthy life extension: making use of diet, lifestyle choices, technology, and proven medical advances to live healthy, longer lives.
- On Skin Photoaging
- Aubrey de Grey and S. Jay Olshansky to Debate
- Cancer Stem Cell Theory Continues to Look Promising
- Discussion
- Latest Healthy Life Extension Headlines
Research into the (somewhat) accelerated aging of skin through exposure to UV light bears some resemblance to aging research in general, and some resemblance to research into accelerated aging conditions like progeria:
"Researchers are largely on the same page when it comes to how aged skin is different from young skin - questions revolve around the processes that lead to that point. As for aging research in general, you can see camps in any sub-field - such as skin aging here - emerge and center around known areas of interest such as mitochondrial damage, telomere shorting, or nuclear DNA damage.
"As in other parts of aging research, no great resolution has been reached as to how much each of these processes contribute to overall degeneration, and which processes might be cause or effect of other processes. All sides have indirect evidence to point to in support of their position, so this might continue for another decade before an evidence-backed consensus emerges."
Longevity science advocates Aubrey de Grey and S. Jay Olshansky will present their respective viewpoints at a September conference on life expectancy and actuarial risk. The conference - and debate - is aimed at those who invest vast sums of money into the longevity insurance and life insurance marketplace, such as hedge fund managers:
"Insofar as anyone gets to be appointed spokesperson, de Grey and Olshansky might be considered spokespeople for the two opposing viewpoints on research strategy in the pro-longevity gerontology community today. On the one hand we have the Strategies for Engineered Negligible Senescence that focus on repair of damage and circumventing incomplete understanding of our biochemistry, with the goal of reversing aging and rejuvenating the old as soon as possible. On the other hand, we have the Longevity Dividend and metabolic engineering, efforts with a focus on establishing complete understanding of our biochemistry and using that understanding to slow down the ongoing progression of aging.
"Note that there are ever fewer voices from the scientific community arguing that we should not or cannot significantly intervene in the aging process. The consensus is that we can, and the important debates are all now over methodology and timelines."
Cancer stem cell theory states that cancers are supported in their growth by a small and distinct population of errant stem cells. Remove the stem cells, such as with the next generation of targeted immune therapies or nanotechnology-based therapies, and the cancer will die:
"A vigorous scientific debate is presently underway. Are cancer stem cells damaged versions of normal stem cells, and do they exist in all cancers? Or are there characteristic ways in which normal cells become reprogrammed into cancer stem cells? After all, induced pluripotent stem cells show that normal cells can be altered in just a few ways to give them the characteristics of embryonic stem cells - such as unchecked growth. Or is it the case that cancers, mutating rapidly, will generate a huge variety of stem-like cells to support their growth, and thus there are few if any commonalities to target?
"All of these points of view presently have some experimental results to back them up. New results continue to be published at a pace that suggests it won't be too many more years before the contradictions are reconciled and the important question answered: are cancer stem cells a short cut to killing most or all cancers? At present it looks plausible that the answer is yes."
The highlights and headlines from the past week follow below.
Remember - if you like this newsletter, the chances are that your friends will find it useful too. Forward it on, or post a copy to your favorite online communities. Encourage the people you know to pitch in and make a difference to the future of health and longevity!
INVESTIGATING GENETICS IN THE OLDEST HEALTHY PEOPLE (August 14 2009)
This open access paper contains an interesting discussion of genetic investigations in the oldest of people who manage to avoid age-related disease and stay comparatively healthy: "Individuals who live to 85 and beyond without developing major age-related diseases may achieve this, in part, by lacking disease susceptibility factors, or by possessing resistance factors that enhance their ability to avoid disease and prolong lifespan. ... Besides genes that have been shown to affect lifespan in animal models, a limited number of genetic variants have been reported to be associated with long life in humans. These studies mainly evaluated genetic variation linked to extreme human life spans (e.g. centenarians) without focusing specifically on health. ... Controversy exists regarding the contribution of these and other gene variants to aging and longevity, because replication studies in different populations, as for replication studies in complex diseases, more often than not fail to confirm the initially reported associations. ... Healthy aging is a complex phenotype likely to be affected by both genetic and environmental factors. We sequenced 24 candidate healthy aging genes in DNA samples from 47 healthy individuals aged eighty-five years or older (the 'oldest-old'), to characterize genetic variation that is present in this exceptional group. These healthy seniors were never diagnosed with cancer, cardiovascular disease, pulmonary disease, diabetes, or Alzheimer disease."
REMINDER: AGING AND HEALTHY LIFESPAN CONFERENCE (August 14 2009)
A reminder that the Aging and Healthy Lifespan Conference will be held on September 23rd - next month - at Harvard Medical School. "Over the next 20 years, the population of Americans over age 65 is expected to double, and health care spending is projected to increase by 25%. With an aging society, it is crucial to understand the challenges and address the opportunities to target diseases of aging, such as cancer and type 2 diabetes, to allow people to live longer, healthier lives. ... Hear leading experts discuss emerging research into scientific and medical advances in aging, as well as lifestyle and demographic trends. This first-ever conference will feature two speaker tracks. One track will focus on new research and insights in the science of aging including updates on the exciting science behind sirtuins and resveratrol. The second track will feature emerging social trends in lifestyles, behaviors and activities of the aging population." Note that longevity science advocate Aubrey de Grey and a number of speakers from the Calorie Restriction Society will be there, alongside researchers whose names I'm sure you'll recognize.
CANCER MORTALITY RATES HAVE TRENDED DOWN (August 13 2009)
Cancer mortality rates have declined for decades now, a trend that we should expect to see continue and accelerate given the technology demonstrations emerging from the laboratories: "Our efforts against cancer, including prevention, early detection and better treatment, have resulted in profound gains, but these gains are often unappreciated by the public due to the way the data are usually reported ... Cancer mortality rates are usually reported as composite age-adjusted rates. These rates have been declining modestly since the 1990's. However, these statistics heavily emphasize the experience of the oldest Americans for whom mortality rates are the highest. As a result, trends emerging in younger Americans can be concealed. As an alternative to age-adjustment, Kort examined cancer mortality rates stratified by age and found that for individuals born since 1925, every age group has experienced a decline in cancer mortality. The youngest age groups have experienced the steepest decline at 25.9 percent per decade, but even the oldest groups have experienced a 6.8 percent per decade decline."
CAN REGENERATIVE MEDICINE DEFEAT AGING? (August 13 2009)
Here biomedical gerontologist Aubrey de Grey defines "regenerative medicine" somewhat more broadly than just stem cell therapies and enhanced healing: "The human body is, ultimately, a machine - an astronomically complex machine, of whose workings we remain pitifully ignorant - but still a machine. Like any machine, it accumulates 'damage' as a side-effect of its normal operation: molecular and cellular changes that occur throughout life are initially harmless, but eventually (when too abundant) increasingly impede the normal operation of the machine and eventually cause it to fail altogether. ... The relevance of nearly all biogerontology research to combating aging is restricted to the potential for slowing down the accumulation of molecular and cellular damage that eventually leads to age-related ill-health. Meanwhile, regenerative medicine has been progressing rapidly and is nearing clinical applicability to a wide range of specific conditions. My view is that we are approaching the point where regenerative medicine can be used against aging. This would entail not retarding but actually reversing the accumulation of damage. If successful, this would obviously be a far more valuable technology than mere slowing of aging. However, in order to be successful it must be comprehensive, and some aspects of aging may seem impossible to address in this way. In fact, however, it seems that all types of molecular and cellular damage which contribute to age-related ill-health are realistic targets of regenerative interventions."
CALORIE RESTRICTION, INTERMITTENT FASTING, AND CANCER RISK (August 12 2009)
FuturePundit looks at one of a number of studies showing calorie restriction to reduce the risk of cancer: "Previous studies have shown that intermittent calorie restriction provided greater protection from mammary tumor development than did the same overall degree of restriction, which was implemented in a chronic fashion. The researchers compared changes of a growth factor (IGF-1) in relationship to these two calorie restriction methods - chronic and intermittent - and tumor development beginning in 10-week old female mice at risk to develop mammary tumors. Their hope was to explain why intermittent restriction is more effective. The overall degree of restriction was 25 percent reduction compared to control mice. Mammary tumor incidence was 71 percent in the control mice who ate the amount of food they wanted, 35 percent among those who were chronically restricted and only nine percent in those who intermittently restricted calories." Which is further evidence for those who suspect that intermittent fasting operates through different biochemical mechanisms to calorie restriction, despite a similar outcome in terms of extended health and longevity.
VETERINARY USE OF STEM CELL THERAPIES (August 12 2009)
The widespread veterinary use of stem cell therapies in past years well demonstrates that there is no good reason for regulatory barriers blocking human application of these technologies: "Vet-Stem, a Poway, Calif.-based company, is developing the stem cell therapy and began treating horses in 2003. It derives stem cells from fat samples taken from dogs and horses across the country. The procedure has been used mainly to treat osteoarthritis, which involves loss of cartilage in the joints, but Vet-Stem is researching treatments for other diseases. Vet-Stem claims the therapy enables animals to replace cartilage and other tissue. Since 2003, the privately held company has treated 3,500 horses and 1,500 dogs and plans to begin treating cats later this year. More than 1,500 vets are licensed to use the procedure. ... Really, all we're doing is harnessing the existing repair machinery in the body, concentrating it, and putting it right where an injury occurs, where healing is needed, to heal naturally. ... One peer-reviewed [study] sponsored in part by Vet-Stem, found that tendinitis in horses was improved by injection of the adult stem cells. Two other studies published in Veterinary Therapeutics found that dogs with osteoarthritis showed improvements in lameness after stem cell injections. Those studies also were sponsored by Vet-Stem and conducted by Vet-Stem researchers and other veterinarians."
THEORIZING ON SIRT3 AND LONGEVITY MECHANISMS (August 11 2009)
This research group proposes that Sirt3 acts on longevity through increasing antioxidants - we should all be appropriately skeptical, given the very mixed evidence for links between cellular antioxidants and longevity. That said, Sirt3 is located in the mitochondria, and the demonstrations of extended life spans through increased antioxidants have involved targeting those antioxidants to the mitochondria. "Sirtuin 3 (SIRT3) is a member of the sirtuin family of proteins that promote longevity in many organisms. Increased expression of SIRT3 has been linked to an extended life span in humans. ... Of the 7 SIRT analogues, SIRT3 is the only member whose increased expression has been linked to the longevity of humans. Polymorphism in the SIRT3 gene promoter, which leads to gene activation, has been found to be associated with an extended life span of man. The molecular basis of SIRT3-dependent longevity is, however, not known. ... In primary cultures of cardiomyocytes, Sirt3 blocked cardiac hypertrophy by activating the forkhead box O3a–dependent (Foxo3a-dependent), antioxidant–encoding genes manganese superoxide dismutase (MnSOD) and catalase (Cat), thereby decreasing cellular levels of ROS. ... These results demonstrate that SIRT3 [protects] hearts by suppressing cellular levels of ROS."
CREATING BLOOD CELLS TO ORDER (August 11 2009)
Creating patient specific blood cells will enable many, many applications - especially in an era of immune therapies. Even the simple ability to greatly multiply the number of white blood cells in a patient's body for a short while can be profoundly beneficial. Here is an update on progress towards engineered blood cells made to order: "In an advance that could help transform embryonic stem cells into a multipurpose medical tool, [scientists] have transformed these versatile cells into progenitors of white blood cells and into six types of mature white blood and immune cells. While clinical use is some years away, the new technique could produce cells with enormous potential for studying the development and treatment of disease. The technique works equally well with stem cells grown from an embryo and with adult pluripotent stem cells, which are derived from adult cells that have been converted until they resemble embryonic stem cells. If the adult cells came from people with certain bone marrow diseases, the new technique could produce blood cells with specific defects. It could also be used to grow specific varieties of immune cells that could target specific infections or tumors."
WHAT CELL REPROGRAMMING TEACHES US ABOUT CANCER (August 10 2009)
As researchers continue to discover and manipulate the mechanisms of cell programming, the new knowledge generated will impact many other fields of medicine: "research links cancer development with difficulties in the new technology of reprogramming normal cells into becoming like embryonic stem cells ... Nearly all cancers have a disabled p53 gene. The gene causes cells that have experienced major genetic damage, which puts them at high risk of turning malignant, to self-destruct. While several mutated genes are implicated in cancer, p53 appears to be the most important one. ... When the p53 gene is removed, normal cells can be reprogrammed into stem cells with a tenfold greater success rate ... If the link is confirmed by other researchers, it would undermine a popular hypothesis that cancers arise from 'cancer stem cells,' caused by genetic changes in stem cells. [Instead] cancer could begin when normal cells spontaneously reprogram themselves, for reasons yet unknown, beginning the process that results in a cancerous tumor. ... A better understanding of how to cause reprogramming could provide clues about how this might arise spontaneously. And that knowledge could be useful in developing cancer-fighting therapies."
CANCER STEM CELLS IN BRAIN CANCER (August 10 2009)
More interesting cancer stem cell research: "researchers report that the STAT3 gene regulates cancer stem cells in brain cancer. Cancer stem cells have many characteristics of stem cells and are thought to be the cells that drive tumor formation. The researchers report that STAT3 could become a target for cancer therapy, specifically in Glioblastoma multiforme (GBM), a type of malignant and aggressive brain tumor. ... STAT3 has been shown to be activated in a number of human tumors. This study is one of the first to show, however, that STAT3 regulates cancer stem cells. It is one of the few genes linked to the propagation of cancer stem cells, and it appears to regulate processes involved in the six hallmarks of cancer: growth, metastasis, angiogenesis, evasion of apoptosis, tissue invasion, and cell immortalization. ... Current cancer therapies that prolong life do not specifically target cancer stem cells, and these cells are often resistant to traditional radiation and chemotherapies. ... When STAT3 is inhibited, cancer stem cells in glioblastomas lose their stem-cell characteristics permanently, suggesting that STAT3 regulates growth and self-renewal of stem cells within glioblastomas. Strikingly, a single, acute treatment with STAT3 inhibitors was effective, implying that a STAT3 inhibitor could stop tumor formation."


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gmp Architects von Gerkan, Marg and Partners wants to provide you with the best possible service. To do that, we store information about your visit using so-called cookies. By continuing to use this site, you agree to our use of these cookies. Detailed information about the use of cookies on this website can be found by clicking on "More information". There you can also disagree with the use of cookies and adjust your browser settings accordingly.
An ecologically designed city quarter for living and working is currently being developed in China's Qingdao, on the coast of the Yellow Sea, to plans by architects von Gerkan, Marg and Partners (gmp). The foundation stone will be laid on 6 December by Ernst Burgbacher, Parliamentary State Secretary of the Federal Ministry of Economics and Wang Chao, the Chinese Vice-Minister of Economics.
After a construction period of two and a half years, von Gerkan, Marg and Partners Architects (gmp) have completed the Tianjin West Railway Station in China. The new intersection, which is located about 130 kilometers south-west of Beijing, serves as a stop on the high-speed line between the Chinese capital and Shanghai.
The inauguration of the new Palacongressi di Rimini conference center will take place on 15 October 2011. The center, which was designed by von Gerkan, Marg and Partners Architects (gmp), who had already designed the Rimini exhibition center, was completed in 2010.
Following their success in winning first prize in an international competition, the architects von Gerkan, Marg and Partners (gmp) have been commissioned to realize a tower block complex of ten buildings in Nanjing. The design by gmp is or a financial enterprise center on a site of about 80,000 square meters in this large eastern Chinese metropolis.
To mark the occasion of the Universiade, which will take place from 12th to 23rd August 2011, the Universiade sports center and Bao'an stadium will be opened tomorrow in Shenzhen, southern China.
The twenty-storey Jiaming Center office block designed by Architects von Gerkan, Marg and Partners has been awarded gold-standard LEED certification by the U.S. Green Building Council (USGBC).
The sports complex was designed and built by architects von Gerkan, Marg and Partners (gmp), who won the competitive bidding in 2008, and constructed it in under two and a half years.
Architects von Gerkan, Marg and Partners will be represented by Cape Town Stadium/South Africa at the 2011 São Paulo Architecture Biennale, as part of the German contribution.
The German Lighting Design Prize 2011 was awarded in Cologne on 5th May 2011. The lighting design for the Moses Mabhida Stadium in Durban was awarded first prize in the International Project category. The lighting design was the work of the lighting-design firm Conceptlicht.
Four years after the foundation stone was laid, the Chinese National Museum in Beijing opens its doors to the public on 1st April 2011. The rebuilding and extension scheme to plans by architects von Gerkan, Marg and Partners (gmp) combines the former Chinese History Museum and Chinese Revolutionary Museum.
Architects von Gerkan, Marg & Partners (gmp), in consortium with landscape architects Bernard & Sattler, have won the competition for the reconstruction of the Federal Environmental Office building in Bismarckplatz in Berlin.
The planned utilization scheme for the building drawn up under the direction of Prof. Meinhard von Gerkan means that this special location will once again be accessible to public cultural life.
Worms's new Culture and Conference Center — designed and built by architects von Gerkan, Marg and Partners (gmp) — along with the efurbished Spiel- und Festhaus theater will open with a special festival week marking the end of nearly three years' construction.
In his lecture, gmp founding partner Meinhard von Gerkan is providing a look behind the scenes of his architectural project as well as the philosophy that has shaped his work since the beginning.
Markus Pfisterer and Bernd Gossmann will present the school campus Miquelallee Frankfurt am Main, designed in modular timber construction, on the second day of SCHULBAU.
On the occasion of the upcoming 100th anniversary of the Bauhaus, Christian Hellmund presents the Magdeburger Stadthalle at the theme evening of Saxony-Anhalt's Chamber of Architects.
In the context of his "Li Dehua & Luo Xiaowei Guest Professorship" Nikolaus Goetze deals in this lecture with gmp projects in Germany - from door handles to airports.
On 7 November, Nicolas Pomränke, associate partner at gmp, will give a lecture as part of the lecture series "Bauen im Kontext" at hochschule 21 in Buxtehude.
On November 2, Johann von Mansberg, Director at gmp, will give a lecture at the FENESTRATION BAU China 2018 trade fair workshop in Beijing on the sustainability aspect of prefabricated buildings.
On Friday, 2 November, Stephan Rewolle, associat partner at gmp, will give a lecture at the FENESTRATION BAU China 2018 trade fair, adressing the question of how high-quality working environments can be created in industrial areas.
On Wednesday, 24 October, gmp partner Nikolaus Goetze will give a lecture on mobility as part of the Master in Design Engineering program, a collaborative degree program between the Harvard University Graduate School of Design and the Harvard John A. Paulson School of Engineering and Applied Sciences.
In the winter semester 2018/2019 Nikolaus Goetze will take over the "Li Dehua & Luo Xiaowei Guest Professorship" as the Chair of Architectural Design at Tongji University in Shanghai. In his inaugural lecture on 10 October, he dealt with how museums can be designed in the future.
Every year, the international real estate industry meets in Munich: gmp will also be present at Expo Real, which takes place from 8 to 10 October 2018. For a personal appointment, contacts from the Hamburg and Berlin offices will be available in Hall B2, Stand 430 on both days of the fair.
When the 13th International Conference on Advanced Building Skins takes place in Bern (Switzerland) on 1 and 2 October, gmp will also be represented: Urs Wedekind, Associate Director at gmp, will talk about "Facade design in foreign markets - First double skin facade in Vietnam" at 10:45 am on 2 October.
"Contraction and Relaxation – New Spatial Concepts for Headquarters Architecture" – that is the title of the lecture on 27th September by gmp partner Stephan Schütz on the occasion of the 2nd Super Tall Building Industry International Summit, which is scheduled to be held on 27-28 September in Shenzhen, China.
The sixth edition of DETAIL's lecture series, "The Future of Building", on 20 September in Munich will focus on modular building. In his lecture at the symposium, Dipl.-Ing architect Christian Hellmund, Director at gmp, will talk about the Gasteig Interim, for which gmp has recently been awarded the contract.
On 13. September, Sara Taberner Bonastre (gmp) will be part of at the VII. Latin American Symposium on Tensile Architecture in the capital of Peru. Her presentation will showcase relevant projects from the gmp portfolio.
On 6 September, the 10th "Stiebel-Eltron Dialogue on the Evolution of Architecture" will take place in the space of BER Airport, at which Hans-Joachim Paap will give a lecture on the topic "Energy Efficiency in Transportation Structures - Demands and Reality".
The project Deutsches Haus by gmp in the heart of Ho Chi Minh City is the first DGNB-certified building in Vietnam. In a lecture by gmp partner Nikolaus Geotze next Saturday and a photo exhibition during the Vietnam Energy Efficiency Building Week 2018 taking place from 25 August to 1 September at the Goethe-Institut Hanoi, visitors can learn more about the building.
Under the headline "Building Bridges - Brücken bauen ", experts from all over the world will meet from 26 to 28 June for the International Baukultur Days 2018 in Venice. Markus Pfisterer, Associate Partner at gmp, will be presenting bridge constructions from the gmp portfolio in a Pecha Kucha format as part of closing panel on 27 June.
The recently reopened Kunsthalle Mannheim considers itself as a "museum in motion". The new building is conceived as a 'city in the city'. On the occasion of the synposium "The Museum of the Future", gmp partner Nikolaus Goetze will be giving a tour of the house on 21 June, explaining the architecture, together with the team of the Kunsthalle Mannheim.
On 14 June, Nicolas Pomränke, associate partner of gmp, will be part of the "Architecture and Acoustics" conference in Vilnius, Lithuania. His contribution focuses on the relationship between architectural appearance and the acoustic demands of a building based on the examples of the Kulturpalast Dresden, Neues Tempodrom Berlin and Qingdao Grand Theater (China).
SOHO Fuxing Plaza (Shanghai, China) by gmp was announced recently by CTBUH as a Finalist project for the Tall + Urban Innovation Conference Awards, in the category of Urban Habitat. Stephan Rewolle, associate partner of gmp, will give a presentation together with the director of design from SOHO China, Yang Yicheng, on the conference in Chicago on May 31st.
Magdalene Weiss, assoziierte Partnerin bei gmp, ist Teil des Panels beim International Forum on Sustainable Urban Development in Shanghai, welches am 15. Mai in den Räumlichkeiten der Tongji Universität in Shanghai stattfindet.
Markus Pfisterer, associate partner at gmp, will be speaking at the World Stadium Congress 2018 in Amsterdam, taking place from 7-9 May. The monumental stadium project by gmp in Krasnodar, Russia will be the focus of various panel discussions with other high profile speakers of the international architecture scene.
"Can architecture heal?" This question is the subject of a new exhibitionat the AIT-Architektursalon Hamburg from 9 to 31 May 2018, showing buildings from the fields of health, nursing, teaching, and research. The book "Healing Architecture" of the same name will be presented at the vernissage on 8 May, where gmp founding partner Volkwin Marg will be speaking about international projects by von Gerkan, Marg and Partners Architects.
The reconstruction of the Kulturpalast Dresden will soon be celebrating its first anniversary. In recognition thereof, the Industrieclub Sachsen has invited the gmp founding partner Meinhard von Gerkan to give a lecture on 24th April providing a look behind the scenes of this architectural project as well as the philosophy that has shaped his work since the beginning.
Smart Cities, innovative forms of mobility and the challenges of city planning in the future – these are the topics of the third edition of IGSI UrbanLab from 23 to 27 April in Berlin, which has extended an invitation to international experts. Once again, gmp is part of this conference, which provides a knowledge transfer and networking opportunities, especially between Germany and India.
In a lecture on 3 April at "The 14th International Conference on Green and Energy-Efficient Building & New Technologies and Products Expo", Wu Wei talks about Architecture and Sustainability. A number of projects are taken as example for the approach of gmp relating to the subject matter.
On Friday, (30 March) the NDR will be broadcasting a new episode of "Nordtour", including a feature with Volkwin Marg. Theme of the program is "Zurück in die 80er in Hamburg".
Magdalene Weiss, Associate Partner at gmp, will be speaking at the "2018 complicated façade innovative design and construction" conference in Shanghai. Other high profile speakers of the international architecture scene participating at the event are, among others, Peng Huijun (Norman Foster) and Zhu Yue (SOM).
As part of the Day of Action Communicating Architecture at Bücherbogen in Berlin on 14 March at 6 pm, the topic of brutalism and post-war modernism will be discussed in a panel debate. Participating in the panel discussion is gmp partner Stephan Schütz, who will be speaking about the Kulturpalast Dresden in a separate lecture beforehand.
At the symposium on building technology on 5 March 2018 at 7:30 pm at the Akademie der Künste in Berlin, it is all about the exchange of practical experience: By invitation of academy members Stefan Polónyi and Klaus Bolling, gmp's founding partner Volkwin Marg will report on the construction planning processes during major projects.
What does a good school building have to fulfill? The participants of the architects' slam will be asked about this question on 7 February as part of the trade fair SCHULBAU 2018 at the Hamburg Cruise Center Altona. The gmp architect Robert Friedrichs will illustrate his recent experience in the planning of a new building for the Gyula Trebitsch School in Hamburg-Tonndorf.
The term "Baukultur" (building culture) becomes the central concept of the discussion: On 1 February, starting at 6.30 pm, at the 13th edition of the JUNG Architekturgespräche in Munich, well-known speakers from the architecture scene will focus on the question of creating a livable environment. Among them is also Stephan Schütz, partner at gmp. A subsequent get-together invites you to a professional exchange.
In the last two decades a number of industrial architecture projects have been realized by gmp in China. They all are creating a whole new character for landscapes and urban areas. With the title "Industrial Buildings in an Urban Context", a new publication impressively illustrates this approach. The book launch on 26 January in Shanghai is accompanied by an exhibition, featuring the esthetics and functional design in architecture and fashion.
As part of a lecture at the NORDAKADEMIE, Hochschule der Wirtschaft in Elmshorn, Volkwin Marg will speak about the "Choreography of the Masses" on 25 January, starting at 5.30 pm. Thus, the gmp founding partner and architect of significant, international stadiums reflects on these from the fields of politics and business.
A review on Berlin after the fall of the wall: On 24 January at 8 pm, the Volksbühne at Rosa-Luxemburg-Platz in Berlin presents Hubert Siegert's documentary film "Berlin Babylon" as a digital premiere. Following the screening, Siegert will host a discussion with the film's protagonists, and dominant players in Berlin's urban redevelopment Meinhard von Gerkan and Hans Stimmann.
Nikolaus Goetze will illuminate contemporary architecture in Vietnam in the mirror of tradition and present on 24 January 2018. The lecture by gmp partner and manager of the offices Hamburg-Elbchaussee, Shanghai and Hanoi is part of a guest lecture for the Institute for Industrial Construction and Constructive Design of the Technical University Braunschweig, and will take place in the Architekturpavillon.
The KAP Forum in Cologne dedicates an "evening about architecture and life" to Volkwin Marg. On 23 January, at 7 pm, the gmp founding partner will speak about his multifaceted oeuvre. Andreas Grosz, curator and director of the KAP Forum, and the journalist Dr. Oliver Herwig will pose the question, which milestones have played a special role in Volkwin Marg's work. The event is already fully booked.
The Roundtable of the Urban Land Institute Switzerland on 16 January at the Zurich airport focuses on the development of AiportCities. Hans-Joachim Paap, associate partner at gmp, will be explaining in this context the challenges of large-scale projects. Using the example of the airport BER project, of which he was in charge for many years, he will be giving insights into the processes behind the scenes.
The Hamburger Denkmalverein extended an invitation for a discovery tour through the Hanseviertel, Hamburg's first shopping passage entirely made of brick. The response has been great: The two guided tours on 12th January, followed by a lecture by Volkwin Marg, are fully booked. There, the gmp founding partner and architect of the Hanseviertel will be providing insights into its design history.


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On a trip to Paris a screenwriter struggling to write a novel experiences a time shift that finds him meeting, being inspired by, and partying with, some of his "golden age" heroes.
Inside a light but funny story, larger than life characters spring up in abundance. Owen Wilson, as writer Gil, is perfectly fine in the lead, as is the resplendent Marion Cotillard. The host of other characters and their actors are a mixed bunch, however. Carla Bruni is marginally passable and Adrien Brody's superbly lunatic Salvador Dali is a highlight. At the other end of the scale, Michael Sheen is awkward and Rachel McAdams' Inez, Gil's fiancé, is such an extreme super-bitch there's no rhyme or reason why the hell the lead character would fall for her in the first place.
With this whimsical, romantic fairy tale, legendary and prolific writer-director Woody Allen is having even more fun than usual. There is always something to appreciate in his work but anyone saying this is a return to form (plenty are, it seems) perhaps needs to revisit Allen's back catalogue. Midnight in Paris lacks the razor-sharp dialogue of Allen's best but it is, without doubt, one of his better recent efforts.
13th Oct 2011 | Official site | On IMDb


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Do you long for a deeper connection with your partner?
Communication in a relationship seems like a simple concept, but it has so many complex layers. If you cannot communicate in a healthy and productive way then you'll encounter many hurdles and even roadblocks as you pursue a close relationship.
When you come in to see me I will actively listen to both of you to understand who you are as individuals and together as a couple, I will objectively look at your relationship from both sides. We will see what is working well for you and where the impediments and landmines are in your relationship. As a highly experienced clinical psychologist, I come to the session with a deep understanding of the various issues that couples face, the variety of potential reasons behind those difficulties and an arsenal of proven methods that can help you both move away from the difficulties and towards a healthier, happier relationship. Part of my job is to facilitate discussion and help guide you through conversations and show you how to dodge the communication landmines so that your communication is more productive and encouraging. You got married to be intimate, to build a life together and not to fight and be miserable. It gives me satisfaction to see couples recognize the roadblocks in their relationship and move forward towards renewed intimacy, with a sense of hope for the future.
Sexuality and Intimacy
I believe that mental and physical health are interwoven. As your psychologist I'm more than willing to roll up my sleeves and work side by side with you through issues like sex and intimacy. These are aspects of a relationship that are often filled with conflict, I'm not scared to ask the tough questions in order to get to the bottom of what you may be experiencing together.
Couples on the Brink
I have seen couples who have already set the wheels in motion for divorce proceedings come in for couples therapy sessions and find a path towards healing. I believe that healing and renewal is possible if both partners really desire it and are willing to work for it. If you feel your relationship is toxic, or beyond salvaging, I am willing to explore the situation with you. I have great compassion and respect for the difficulties that some relationships face, and I utilize many resources I've learned over the years to see that you get the help that you need.
A Safe & Positive Environment
My mission in couples work is to help you build resilience that will help you in all of your relationships in life. As your therapist, you will find me open, engaging, and straightforward. My office is conveniently located and has a quiet and professional atmosphere. You will feel at ease with the privacy and comfort it provides.
I am trained in a broad spectrum of therapy models that allow me to choose what approach will best fit your unique situation.
My experience includes but is not limited to:
You are welcome to check out my website by clicking on the link below. There is a reason that you are reading this profile, call me now to move towards that better relationship. I welcome your phone call so that we can see if we are a good fit, if not then I may have a referral for you that would be a good fit. Contact me now for a free phone consultation.


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Dr David Sykes
Dementia Australia
Director, Dementia Training Australia; Director, Dementia Australia Centre for Dementia Learning
Dr Sykes leads Dementia Australia's Centre for Dementia Learning which has been at the forefront of learning technologies including the multi award-winning Virtual Dementia Experience and the Educational Dementia Immersive Experience (EDIE). The team was recently awarded Victorian Small Training Provider of the Year.
Dr Sykes was involved in the establishment of the Victorian Disability Services Commissioner, worked for 10 years with the Office of the Public Advocate, is a graduate of the Williamson Community Leadership Program, and completed his doctorate on the development of a model of advocacy practice for working with people with a cognitive disability.
As Director of Dementia Training Australia, Dr Sykes is responsible for Dementia Essentials, DTA's nationally accredited course for workers who support people living with dementia.
Queensland University of Technology
Director, Dementia Training Australia; Director, Dementia Centre for Research Collaboration
La Trobe University, Victoria
Director, Dementia Training Australia; Senior Research Fellow, Australian Centre for Evidence Based Aged Care, La Trobe University
University of Wollongong
Executive Director, Dementia Training Australia; Professor, Faculty of Science, Medicine and Health, University of Wollongong


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You publish a 25Live® calendar to the Web when you want to make it available to the public. You then embed the published calendar spuds into your own website, giving site visitors all the benefits of your active Trumba calendar right on your site. subscribe to it or take other actions on events.Visitors to your calendar can
After you publish the calendar, the spud code is also served up on a rendered calendar that is hosted on a CollegeNET server and given a unique Web address (URL). While this URL is available to anyone who has access to the Web, it appears under the 25Live.com domain, such as in the following example, so is primarily a preview and test tool for internal use only:
Note If you've already worked with your Trumba Sales representative to get an event submission form, you may also be able to use it with your hosted calendar. For more information, go to Get an event submission form.
To publish your calendar and put it into your website, you complete two separate steps.
|When you're done entering events, go to the calendar you want to publish, click Publish, select a default view, select the calendars you want to mix in, and specify other publishing settings.
|Each publishing setting has a description of what it's for, along with additional help and tips that you can open by clicking the green Help buttons ().
|Paste code that 25Live Publisher generates for calendar spuds into your own web pages. Visitors get the benefits of a 25Live Publisher active calendar without leaving your site.
Views and spuds are terms you'll see referred to a lot in the context of publishing 25Live calendars.
When you publish your calendar, you select a default view. The view sets the calendar layout and other attributes that determine how events are presented on the main calendar. For example, for some views, you can change the number of events that appear on a page and how they're grouped within that page. You can also allow visitors to select multiple events to take action on, or disable update markers that appear when you make changes to your events. Each view has its own customization settings.
After you publish your calendar, 25Live Publisher makes your calendar available in a few standard views in addition to your default view. You can add, remove, and customize views in the Publishing Control Panel.
For every calendar you publish, 25Live Publisher creates calendar spuds, each of which presents your calendar data in a different way. Spuds behave like portals on your web pages, which draw calendar information directly from the 25Live server on which your calendar is hosted. Because they draw information from 25Live Publisher, spuds on your site immediately show updates you make to your calendar in 25Live Publisher.
Some examples of spuds are:
And more
In the Publishing Control Panel that appears after you publish your calendar, you can see the spuds that are available in each spud category on the various tabs.
The hosted view is a view of your published calendar that is hosted on the 25Live servers. Each hosted view has its own unique URL.
If you're not ready to embed your spuds and you want to preview and test your published calendar, you can take advantage of the hosted view.
For example, you can test event and calendar actions by setting reminders, adding events to your personal calendars, subscribing to the calendar, and more. You can test control spuds you have implemented by searching for events, switching between views, hiding and displaying mixed-in calendars, and more.
If you enable mobile view, you can narrow your browser window or use a mobile device to test how your calendar will look on smaller screens.
You have the option of customizing the hosted view settings (for example, which control spuds to display, whether or not to add a logo or enable mobile view) and styles (for example, page and sidebar background colors, text colors and sizes, and more). Keep in mind that while an Internet search might send an occasional visitor to the hosted view, the view is primarily a preview and test tool for your internal use.
The hosted view displays a selection of control spuds to the left of the calendar.
By default, in narrow browser windows (less than 735 pixels wide) and on mobile devices, the hosted view is set to automatically hide the control spuds. To display the spuds in narrower environments, you can click Show Controls above the calendar.
Tip If you set your calendar to automatically detect mobile, when you preview the hosted view on a mobile device, you see a mobile table view specifically configured for the narrower mobile environment. Learn more.
To preview a published calendar's hosted view and find the view's URL
If you want to provide a link to the hosted page, copy and paste the URL. Replace View My Calendar with whatever text you prefer.
To view the hosted page at any time, put the following URL into a browser's address bar:
Replace webname with the web name of your calendar.
If you want to brand the hosted page with a photo or logo, add the image. Provide a URL to link the image to a webpage.
On the Styles tab, set the colors and font sizes you prefer.
At the bottom of the form, click Preview to preview your customization choices. When you're satisfied with , click OK.
After you place calendar spuds into your site using the default settings, you might see that the design of the calendar doesn't exactly match the design of your site. In that case, you can take advantage of the flexibility 25Live Publisher provides in customizing the views you provide of your main calendar, as well as styles and other settings for any of the spuds you want to use.
In the Edit Publish Settings page, you select a default calendar view, the calendar name, mix-ins, and other settings that apply to the main calendar behavior. You can change these settings any time.
The topics listed here provide more information for selecing settings on the Edit Publish Settings page.
Default view
Publishing settings
Mix-in events: Mix other calendars into your published calendar
Event filters: Filter spuds
Email settings: Enable or disable the visitors' option to subscribe to your event email
If your published calendar is no longer relevant, or you change your mind about making it available on the Web, you can unpublish it to remove it from the Web and remove it from your website.
Note If you unpublish a calendar but do not remove spud code from your own web pages, the spud code will display a Calendar not available error message on your pages.
If your calendar was indexed by a search engine while it was published, even though the calendar no longer exists on the Web, its name, description, URL, and other searchable event information may still be listed in relevant search results until the search engine re-indexes the 25Live Publisher public calendar site.


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· Translate designs and wireframes into high quality code
· Design and build applications for the iOS platform
· Ensure the performance, quality, and responsiveness of applications
· Collaborate with a sports scientists and software development team to define, design, and ship new features
· Identify and correct bottlenecks and fix bugs
· Help maintain code quality, organization, and automatization
· Work in an Agile environment
About STATsports…
STATSports has grown from its humble origins in Ireland to be the world-leading provider of GPS player tracking and analysis equipment.
The STATSports APEX/Viper System is a customer driven platform. The unique, user-friendly interface was designed and shaped alongside some of the world's top strength coaches, medics and sports coaches. It is the only system to offer sports specific software for Football, Basketball, American Football, Rugby and Athletics.
Our Pods have been tried and tested by many of the top teams and research facilities the world over and time and again results prove our system to be the most accurate, reliable and consistent device on the market.
Check us out at www.statsports.com
About you….
· Degree in Computer Science, Engineering or related subject
· A minimum of 3 years' experience developing with iOS frameworks
· Expert knowledge of Swift and Objective C
· Experience with developing & consuming RESTful APIs
· Knowledge and experience of working with low-level C-based libraries
· Proficient understanding of code versioning tools (such as Git)
· Familiar with continuous integration
· Pro-active with the ability to work with little/no supervision
· Experience working with external devices over different wireless protocols
· Experience in real-time data applications.
· Knowledge of other mobile technologies (Native/hybrid) and UI/UX standards
· An interest in health and fitness and sports industry
· Familiarity with the use of additional sensors, such as gyroscopes and accelerometers
· Experience using cloud platforms such as AWS or Azure
· Familiarity with other object-oriented languages
Why work for STATSports….
Salary- competitive/ negotiable
28 days annual leave (including statutory holidays)
Pension Scheme
Life Cover
Critical Illness Protection
Income protection
Investment in our team -we are very focused on training our staff and providing the best CPD as we possibly can. Investment into our employees' development is key!
Our team- Each member of STATSports has been handpicked to the highest standard. Each staff member is passionate about STATSports and the work they do. We work hard but also have the best craic!
Join the success- read about our most recent success stories:


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A Way to Start a Spiritual Conversation
Words matter. With eyes of wonder, believers in Christ grasp on to the words of grace, redemption, and justification. These words define the Christian faith. The meaning behind these words appear obvious to the faithful but may have an entirely different connotation to an unbelieving world. And this chasm of misunderstanding is growing wider. It's …
God's Foolish Errand
God works through the power of his Word to bring salvation to all people. God commissions his church – his body of believers – to go out and spread his Word to the world. Is that God's foolish errand?!
Names recorded by God serve a purpose
The pages of Holy Scripture open and you read names. Names associated with acts of faith, devoted service, or a heinous response from unbelief. In God's inspired Word, names are recorded and preserved over the course of centuries. What about your name?
Four discoveries when Christians exercise their faith and proclaim the gospel
Chuckling in your face. Wincing in disapproval. Polite smiles with a faraway look in their eyes. God's Word has that effect on lost souls. When believers receive disappointing responses from proclaiming the gospel, it can cause us to think twice when opportunities arise again. What are ways that a Christian believer can continue to be …
Evangelists have the best seats in the house
There are box seats in baseball stadiums and prime seats on the 50-yard line. They are not only the best seats to see all of the action, but they are expensive and prestigious. What are the best seats in the kingdom of heaven?
The Lord is my caregiver… I lack nothing
If the Lord is my shepherd, can I really trust in him? The familiar words of the twenty-third psalm answer this question and can resonate during times of uncertainty. The Lord paints a portrait of what it's like to be wholly dependent on him. The Lord is not just my Shepherd; he is my caregiver.
Moving from being a Good to Great Samaritan
There are hurting people out in the world. Physical needs, emotional hurts, and loneliness are just some of the ills that infect our sinful world. In this busy world, we often don't see life's litter on the side of the road. Neighbors artfully disguise their problems and hungrily look for the world to ease their …
How Evangelists Use the Law Before Proclaiming the Gospel
The gospel is the Good News of what Jesus Christ has already done for us. Jesus was crucified, buried, and rose again on our behalf. It is the power of the Holy Spirit working through the message of the gospel that creates faith in an unbeliever's heart. The saving work of the Holy Spirit can …


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- women's tuxedo flare trousers in lavender blue - flared cut- zip closure, button and hook- ultra-comfortable fluid and stretch fabric, light blue- piped back pockets, buttons and side bands in sky blue satin- can be worn together with its original matching blue tuxedo jacket in japonese style embroidery
Composition: 96% polyester, 4% elastane.
Stefanie Renoma timeless collection borrowed from menswear, largely feminized by its cuts worked so highlight your major assets.
SHIPPING POLICY l TERMS AND CONDITIONS l RETURN POLICY I CUSTOMER SERVICE


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On last night's Bravo episode of "Millionaire Matchmaker," Patty Stanger was teaching a class of women how to flirt with a guy. She met with her staff and complained that chivalry is dead. Rachel told her they have a new millionaire client, and it is Denise Richards' father, Irv. Patty has been begging Irv to do this, and now it finally happened.
Irv has been a widower since he lost his wife to cancer. He is 62 years-old and a real estate investor. His wife died about three years ago, and he has been living with Denise to help out with the grandchildren. His celebrity crush is Felicity Huffman, but she is married to William H. Macy. Patty gets her staff to work looking for a woman who resembles Felicity. Irv is a sweetheart who Patty just loves. He is ready, willing and able to find his next soul mate. Irv will be sitting behind a two-way mirror with Denise as Patty interviews the candidates.
Next Patty visits Stephanie, a 30-year-old millionaire who has a distinctive voice; something like a cartoon character. She is looking for a mate, and she is worth big bucks. She has dated losers in the past, and needs Patty's help. Patty set the rules for Stephanie to follow and plans to introduce her to a few candidates, and she introduced Irv to Stephanie to watch the interviews. She wants Stephanie to treat Irv like her father and critique the candidates. Irv found the woman he liked the best and had to leave with Denise to pick up the kids from school. Des stood in with Stephanie to help her behind the two-way mirror.
As Patty interviewed the men, she asked pertinent questions. Patty pulls no punches when it came to her choices and did not want her to choose her previous douche bag types. Most men were losers, in Patty's estimation and she told them to their faces.
Stephanie went to the Wildlife Learning Center to meet Bradley. The both love animals and got to touch them as they got to know each other. Bradley seems to have a story relating to a movie about every animal he sees and is surprised that Stephanie is not very familiar with movies. She thinks he is a dork, but not a douche bag. They go to dinner next. Stephanie was not happy when he said that he was on over four hundred dates.
As Irv meets Sherilee at his home, where he hired a personal chef to make them a memorable meal. They got along very well and seemed to be a perfect match. Irv seemed very happy with his choice. The connection was made, and a future date will be in Yosemite, where neither of them have ever been.
Bradley called Patty the next day, and she quickly got off the phone with him because Stephanie was coming in. She did not make a match with Bradley, but Irv's match was awesome, and they are dating. Denise is thrilled that her father has found love again and so is Patty.
Stephanie will be looking for fewer dorky guys in the future, but ones who are gainfully employed thanks to the "Millionaire Matchmaker."


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Slovakia: austrian multinational bets on time against Slovakian workers
"They want to starve us out,"
"They want to starve us out,"
Dear collegues,
Neusiedler/Mondi bussiness paper SCP a.s. takes legal action against workers involved in setting up a trade union.
Workers and international socialists meet in Ruzomberok
Reply to a letter dated 22 November 2004, sent by the CEO of the company to all the employees.
The management of the Austrian based multinational Neusiedler in Ruzomberok, a town in central Slovakia, has decided to hand out redundancy notices to all workers who were involved in organising a new trade union.
A three-day national railway strike paralysed Slovakia from 1-3 February. The government clamped down on the strike using the High court to declare the action illegal.
CWI- Please inform us if you are reproducing any material from this site.


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We're excited to hold our first anniversary party, Summer Vibes, on August 17 (Sat) 8:30 – 10pm! The highlight of the party is our in-house showcase, which will feature 2 bungee and 2 dance acts, and we're inviting you to be part of the performance!
We're excited to hold our first anniversary party, Summer Vibes, on August 17 (Sat) 8:30 – 10pm! The highlight of the party is our in-house showcase, which will feature 2 bungee and 2 dance acts, and we're inviting you to be part of the performance!
On Sunday, Nov 25, Coreo is kicking-off a new era by adding yoga and Pilates classes to the lineup! To celebrate these new additions, we'll be offering these classes for FREE before Thanksgiving from Nov 18 - 2.
Did you have a strong fitness routine in the beginning of the new year? Are you losing momentum? It happens to the best of us. The beginning of the year is the easiest time to set goals as you're feeling renewed, refreshed and ready to take action. Don't let a small lapse in commitment and motivation get the best of you. With a few helpful tips you can stay committed to your workout, whether it's on or off the bungee.
Making a fitness a habit can be hard. So we'll make it easy for you in 2019: for every ten classes you take throughout January, we'll throw 2,000 Coreo Rewards points your way, which is equal to $40 in store credit!
We are often asked, "What should I wear in class?" Here are some recommendations based on our instructors' and clients' experiences.
Trick or treat-yo-self by celebrating Halloween at Coreo Fitness! From Thursday, Oct. 25 to Wednesday, Oct. 31, Coreo is offering unique Halloween-themed Bungee Workout classes for guests and members to take their Halloween getups to new heights.
Let me guess: you watched a video on social media about the Bungee Workout. People were flying through the air like Peter Pan-- it looks so exciting! You are eager to try the class and take pictures for the 'gram. But you may be wondering, "Is Bungee a real workout?" The answer is YES! The Bungee Workout is indeed a workout, and it is more than a novelty experience. While our location attracts visitors from out of town, Coreo Fitness classes are designed to be incorporated into a routine fitness regime.
A new workout has bounced its way into Seattle! Coreo Fitness in lower Queen Anne lets people leap their way into shape...while attached to a bungee cord.
One of the newest fitness trends in the country has made its way to the West Coast and landed in Seattle. Coreo Fitness will open in August of 2018 on First Avenue North in the Uptown neighborhood. A grand opening celebration will be held on August 18 and 19 from 10:00 am – 5:00 pm with two morning classes and demos throughout the afternoon.


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I saw this card layout on SplitCoastStampers.com but unfortunately I don't remember who made it. The original card had buttons where I have used flowers.
I was feeling totally uninspired to stamp so decided to set myself a challenge. I recently bought a book by Claudine Hellmuth which includes cards for colours and topics. She adapted the idea from something she did at art school, so as the topics don't really apply to cards I decided to make my own lists.
Here are some examples from the four lists I used:
Topics - wings, funny, places, background
Colour - black, red, pink, purple
Embellishments - brads, ribbon, designer paper
Company - ellusive images, bella,
I labelled them all 1 to 10 using excel and asked my hubby to choose a 4 digit number. The number he picked gave me Topic = Place, Colour = Autumnal, Embellishment = Flowers and Company = Bella. The Bella stamp I used is called Paris, so that is also the place. :-)
Why not write lists to suit your preferences. My lists also include use a new stamp/old stamp, use something from my desk and open a random box!
Have a lovely week, Anne
Paper - Stampin Up
Markers - Stampin Up and copics for the dog
Flowers - Prima with zoom dots
Sentiment - Kirsty Wiseman CD


text: Bridal Bouquets Victorian elegance in a bouquet of hydrangea, peach spray roses and hypercum Stock, Calla Lily and Lisianthus combine to make for a smooth and delightful bouquet Purple ranunculus, green cabbage and cymbidum orchids combine with seeded eucalyptus to make for a fall delight Creamy confection of Garden Roses, Stephanotis with pearl pins and calla lilies. Cascade of pink and white Purples combined with white English Garden Roses make for a dream come true. Pins of diamonds and a diamond wrap make this bouquet fit for Princess. Succulents are featured in this fabulous fall bride's bouquet. Shades of Orange make for a bright and colorful fall bouquet. The cascade is making a comeback! I love this one as the camera really captures the visual excitement of the llilies. Cool colors of lavender, blue and white combine to make for a romantic and a relaxed presentation. Roses, callas and queen anne's lace make for a Victorian styled bridal bouquet. Classic round clutch of all white roses. Pink Peonies, Garden Roses and Hydrangea, perfect for the Summer Bride! Pink Peonies, Garden Roses and Hydrangea, perfect for the Summer Bride! Perfection in Pink or is that "Confection"? Pale pink Peonies and Pale pink roses combine for a delicacy that makes the taste buds water. Fully Open White Roses and Deep Purple Vanda Rothschild orchids make this stunner simple and elegant. Peach, White and Champagne colored Roses combine with Mango Calla Lily to make this blinging cascade bouquet full of " fabulosity". The finest flowers from Holland. White Carolyn Tense Lily, Pink Astilbe, Bouvardia and Larkspur make for a Gourmet presentation. The The Classic All White Cascade. Always in Style. Casablanca lily, Vendela Roses and white dendrobian orchids combine to make a face front show the camera loves! Flowers are alive and this bouquet moves. As the bride walks, the seeds that cascade move with her.