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WHAT: The second annual Hulakai Stand Up Paddle Race To Fitness
WHEN: Saturday, Sept. 29. Participant briefing at 7:30 a.m. Race at 10 a.m.
WHERE: Kohala Coast. Meet at Hulakai store at The Shops at Mauna Lani. 68-1300 Mauna Lani Drive.
Race finish at the Mauna Lani Bay Hotel & Bungalows. Complimentary parking.
BRING: Your own board or canoe or hire in advance from Hulakai
Mauna Lani Bay Hotel & Bungalows is teaming up with local stand up paddle board and ocean sports company, Hulakai, to present the second annual Stand Up Paddle (SUP) Race To Fitness on Saturday, Sept. 29 along the Kohala Coast.
The race is Hawaii Island's biggest SUP fitness event for all ages and levels. It's about celebrating the heritage of SUP in Hawaii and its evolution as one of the fastest growing water sports and fitness workouts in the world.
One and two person outrigger canoes, surf skis and prone paddleboard enthusiasts are also invited to join in the fun.
The race will start from either Kiholo Bay or Kawaihae Harbor depending on the wind direction on race morning. The finish line is at Mauna Lani Bay.
The distance from Kiholo Bay is 7.2 miles and from Kawaihae, it's 7.4 miles. The start location will be announced at a pre-race briefing held at Hulakai's store at The Shops at Mauna Lani. Each participant will have their race time recorded.
The Mauna Lani Bay will host an oceanfront after-race BBQ and awards ceremony featuring DJ Hype 808 and fun activities for children.
Prizes will be awarded for the top three finishers along with category winners.
To enter SUP For Fitness and for further information, contact 808-887-1091 or visit www.hulakai.com


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Order Systems
Mobile Apps
MarineM's Marine Scheduler application schedules Pilots, Tugboats and Pilot Boats to marine jobs and berth assignments.
Forget about paper-based forms and manual monitoring. marineM Apps eliminates tedious processes that manually manage marine operations. marineM Apps provide a critical link between the marine back office planning and marine operations.
MarineM provides a top to end ERP platform that covers the scope of marine business processes and operations.
MarineM Billing automatically generates bills considering billing parameters including job types, vessel, tariff and service duration and customers.
We had been on the hunt for an enterprise grade maritime software to handle our towage operations and we found the best solution with marineM. A thorough evaluation process proved marineM to be the answer to all our operational needs.
David Tan
Head of IT, POSH Semco
We had been on the hunt for an enterprise grade maritime software to handle our towage operations and we found the best solution with marineM. A thorough evaluation process proved marineM to be the answer to all our operational needs.
David Tan
Head of IT, POSH Semco
From marine ordering process and planning and scheduling of resources for approved orders to fulfilment of orders (i.e. Towage, pilotage operations) and marine billing, MarineM provides the technology to manage and monitor all critical aspects of the operations.
marineM's Marine Ordering System provides a user friendly web based interface for registering and capturing order details for pilotage and towage resources.
Marine Ordering System also provides the capability to manage demand for pilot and tugboat resources, as well as track financial status and credit limit of customers.
marineM Planner features an intuitive graphical interface based on Gantt Chart design. Each task provides a realtime update of the actual status of the event.
The application considers routes, suitable tugboats based on power versus ship size, ship vessel size, experience of pilot, and many other things.
Provides features for assignment of ship to berth upon considering various constraints such as ship fitting to berth, assignment based on recurrence or a one off event, and clash checking unique assignments.
marineM Apps ensures instantaneous status updates for every allocated task including pilotage and towage services for better planning.
marineM Apps delivers a live capture of key and critical job progress status and other important inputs for operational updates and accurate billing.
The real time data is transmitted wirelessly over existing 3G or 4G telecommunication networks, which provides detailed and timely updates for every deployed resource.
Key billing parameters such as duration spent in delivering pilotage and towage services are electronically captured during the job.
Marine bills are generated automatically upon completion of pilotage and towage services. Billing considers job types, customer specific billing schemes are used for the final calculation of bills.
With pricing schemes, marine services charges are computed based on a combination of various inputs including customer service agreements, time of the day, job performed, duration of pilotage, duration of towage, tariff rates, job types and others.
Data Manager
Manages key data records such as Pilot, Vessel, Location, Berth, Job Types.
Customer Manager
Manage customer records, customer contacts and accounts information held in each record.
Bill Manager
Tracks generated bills as well as provision features to override bills actions and statuses.
Job Order
Registers and record orders details for towage, pilot services with each arriving or departing ship vessel.
Service Management
Manage the status of pilotage and towage service records.
Automated constraint based planner that assigns tugboats, pilot to marine jobs as well as arrange transport logistics for pilots.
User and Roles Manager
Manage users access to the system based on permissions assigned to user and roles.
System Audit
Tracks and review every change made in the system by any user. In particular all bill details and changes are recorded in System Audit.
Singapore Head Office
51 Goldhill Plaza #10-09
Singapore 308900
Wisma Mampang Building 5th floor Jl. Mampang Prapatan Raya No. 1 Jakarta Selatan DKI Jakarta Raya 12790
180 Piccadilly, London, W1J 9HF United Kingdom

subset: commoncrawl


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Sunday, 26 October
Monday, 27 October
Tuesday, 28 October
Wednesday, 29 October
Thursday, 30 October
Software product lines have emerged as a new and very important software development paradigm. A software product line is a set of software-intensive systems sharing a common, managed set of features, and that are developed in a disciplined fashion using a common set of core assets. Organizations developing their family of products as a software product line are experiencing order-of-magnitude improvements in cost, time to market, staff productivity, and quality of the deployed products. This tutorial covers the basic concepts of software product lines, the essential software engineering and management practices, and product line practice patterns that let an organization apply the practices in a way best suited to their individual needs. The concepts are illustrated with one or more detailed case studies of actual organizations' experiences with the software product line approach. The tutorial contents are based on the book "Software Product Lines: Practices and Patterns."
Attendee background
Prerequisites: Participants should have experience in designing and developing software-intensive systems and some familiarity with modern software engineering concepts and management practices.
Lecture (65%) with discussion (20%) and short exercises (15%)
Linda Northrop is currently director of the Product Line Systems Program at the Software Engineering Institute (SEI). She is co-author of the book, "Software Product Lines: Practices and Patterns." She received the 2001 Carnegie Science Center Award for Excellence in Information technology, was a keynote speaker at ICSE 2001 and AOSD 2002, OOPSLA Program Chair in 1999, OOPSLA Conference Chair in 2001, and the Conference Chair of the first and second international Software Product Line Conference (SPLC1 and SPLC2). She chaired the first Software Product Line Conference and is the current OOPSLA Steering Committee Chair.
Paul C. Clements is a Senior Member of the Technical Staff at Carnegie Mellon University's Software Engineering Institute. He is co-author of four books on architecture and product lines: "Software Product Lines: Practices and Patterns," "Software Architecture in Practice," "Evaluating Software Architectures: Methods and Case Studies," and "Documenting Software Architectures: Views and Beyond."
Today, domain-specific visual languages provide a viable solution to raise the level of abstraction beyond coding. Industrial experience has shown productivity improvements of 5-10 times. We believe that it is time to start talking about Domain-Specific Modeling as the new paradigm for developing applications and product families for a given domain/platform.
In domain-specific modeling the models are constructed using concepts that represent things in the application domain, not concepts of a given programming language. The modeling language follows the domain abstractions and semantics, allowing developers to perceive themselves as working directly with domain concepts. Together with generators and components DSM can automate a large portion of software production.
Workshop topics:
Industry/academic experience reports
Product-line architectures promise better productivity and less maintenance costs for families of related software systems. A strong product-line architecture is one of the keys to a successful deployment of both product lines and any system destined to go through multiple releases. However, specifying high-quality product-line architectures is a surprisingly difficult task.
Commonality and variability analysis is a powerful domain analysis tool for the specification of product lines. It can help designers produce systems that are robust in the face of change, and that can be easily customized. Additionally, it feeds naturally into OO design. This combination provides a proactive, systematic approach to accomodating changes in software.
This tutorial introduces commonality and variability analysis in a real-world setting. Topics include: underlying principles, methodology, and synthesis with OO design. By the end of the tutorial, you will understand how to use commonality and variability analysis in your OO projects to specify a stable, yet flexible, software architecture.
Attendee background
This tutorial is aimed at architects and designers of systems that have many variations, such as product families and systems with multiple releases.
Prerequisites: Attendees should have solid background in OO principles, and some OO design experience. Experience in specification or analysis is helpful but not required.
Lecture with exercises
Neil Harrison is a researcher at Avaya Labs, where he consults with software projects in architecture, process, organizations, estimation, and product line engineering. He has been involved in software patterns since 1994. He has organized pattern conferences and has taught many courses on patterns. He is a member of the Hillside Group board of directors. He has published patterns and chapters in pattern books, and was lead editor of Pattern Languages of Program Design, Volume 4.
Frank Buschmann is senior principal engineer at Siemens Corporate Technology in Munich, Germany. His interests include Object Technology, Software Architecture, and Patterns. Frank has been involved in many software development projects. He is leading Siemens' software architecture research activities. Frank is co-author of "Pattern-Oriented Software Architecture -- A System of Patterns" and "Pattern-Oriented Software Architecture -- Patterns for Concurrent and Networked Objects".
The main goals of software reuse are to increase quality, reduce cost, and shorten development cycles. The interesting question in this context is: How to achieve reuse in constrained environments? In desktop and enterprise systems, object-orientation, components, frameworks, service-oriented architectures and, most recently, model-driven development are proposed as cornerstones for efficient reuse. In constrained environments (i.e. embedded and real time systems, PDAs, smart phones, settop boxes) reuse is not as simple, because most reuse techniques imply some kind of overhead: memory, performance, or determinism.
This workshop explores practical reuse techniques for constrained environments. Potential topics include, but are not limited to:
Model Driven Architecture (MDA) is an initiative by the OMG to leverage UML-based modeling techniques to insulate abstract software system specifications from implementation dependencies. The workshop focuses on generative techniques that can be used to realize MDA. We aim to bring together practitioners, researchers, academics, and students to discuss the state-of-the-art of generative techniques in the context of MDA. The OOPSLA'02 workshop on this topic was highly successful and led to the launch of the Generative Model Transformer (GMT) open source initiative.
Topics of interest include:
The goal is to share experience, consolidate successful techniques, and identify the most promising application areas and open issues for future work.
Large information systems need a domain model. Development teams know this, yet they often end up with little more than data schemas. This tutorial delves into how a team, developers and domain experts together, can engage in progressively deeper exploration of their problem domain while making that understanding tangible as a practical software design. This model is not just a diagram or an analysis artifact. It provides the very foundation of the design, the driving force of analysis, even the basis of the language spoken on the project.
The tutorial will focus on three topics:
The tutorial will include group reading and discussion of selected patterns from the book "Domain-Driven Design," Addison-Wesley 2003, and reenactments of domain modeling scenarios.
Attendee background
Prerequisites: Attendees must have a basic understanding of object-oriented modeling and the ability to read UML. Some involvement, past or present, in a complex software development project is helpful in seeing the applicability of the material, but is not essential. Familiarity with the practices of Agile Methods and/or Extreme Programming is helpful, but not essential.
Interactive reading/discussion session, and simulations of the activities and processes that go into making domain design decisions.
Eric Evans is a specialist in domain modeling and design in large business systems. Since the early 1990s, he has worked on many projects developing large business systems with objects and, since 1999, has been deeply involved in three projects committed to the Extreme Programming process (XP), and has trained teams in the Extreme Programming process. Out of this range of experiences have emerged the synthesis of principles and techniques shared in the book "Domain-Driven Design," Addison-Wesley 2003.
Ralph Johnson is a co-author of the now-legendary book, "Design Patterns" (Addison-Wesley, 1995). He is on the faculty of the Department of Computer Science at the University of Illinois. He is the leader of the UIUC patterns/Software Architecture Group and the coordinator of the senior projects program for the department. His professional interests cover nearly all things object-oriented, especially frameworks, patterns, business objects, Smalltalk, COM and refactoring.
This tutorial presents an introduction to the interlocking business, organizational and technical issues that influence large-scale software reuse and asset-based software engineering. Asset reuse is one of the most significant enablers for productivity improvements; it appears simple at first glance, yet is difficult to execute. Most organizations do not know how to effectively structure a reuse program to match their business and software goals. We describe three primary flavors of reuse: Facilitated, Managed and Designed. An organization selects and practices one or more of these flavors of reuse by varying the amount of proactive management of assets and process; proactive design and architecture of assets to enhance reuse, and amount of top-down, pre-work, versus bottom up incremental reengineering. Particularly important is how it encourages or enforces use of these assets, how it invests in the people, process and technology to support the reuse program, and how it structures and manages the organization to provide, support and utilize the assets. Topics covered include: Business and economic issues; reuse experience; flavors of reuse; architecture, components, frameworks and product lines; reuse process and design methods, domain engineering; reuse governance and organization; and technology and tools such as templates, aspects, generators and repositories.
Attendee background
Prerequisites: This tutorial is geared towards managers, architects and senior developers who have some software engineering, programming and modeling experience, and who are eager to establish or refine an asset reuse program.
Lecture and interactive discussion
Martin Griss is one of the world's leading authorities on software reuse. He spent nearly two decades as Principal Laboratory Scientist and Laboratory Director at Hewlett-Packard Laboratories. Known as HP's "Reuse Rabbi," he created and led a corporate-wide software reuse program. His research has covered software reuse processes and tools, software engineering tools and methods, and software agents. He is co-author of "Software Reuse: Architecture, Process and Organization for Business Success," and author of over 60 book chapters, papers, columns and reports. He is an Adjunct Professor of Computer Science at the University of California at Santa Cruz, a consultant, and member of Flashline's Software Development Productivity Council.
The Generic Modeling Environment (GME) is a metaprogrammable, domain specific, graphical editor supporting the design, analysis and synthesis of complex, software-intensive systems. It is closely related to metaCASE tools such as MetaEdit+ or Dome. Over a decade of research in model integrated computing has led to the development of GME. The toolset has been applied to modeling and synthesizing several real world applications for both government and industry organizations.
GME has an architecture based on MS COM technology and is implemented in C++. The Core component exposes the domain-specific language specification through a set of COM interfaces. It has another set of interfaces for model access. All the other components, (GUI, browser, OCL constraint manager, software generators, etc.) are built independently around the Core. Model persistence is supported via standard database technology and XML persistence. The technologies applied throughout GME (UML, OCL, COM, XML) make it easily applicable and extensible.
The demonstration will focus on using GME to develop an integrated simulation framework for embedded systems. The UML and OCL based metamodels specifying the domain-specific visual modeling language will be examined. We'll demonstrate how the domain-specific environment is automatically generated from these metamodels. We'll emphasize how the target visual language supports such OO concepts as type inheritance and multiple aspects. The automatic extension of the model access interface will be shown. This interface makes extensive use of OO techniques such as inheritance. We'll show an example application, including its complex models and the automatically synthesized simulation and C code.
Feature-Oriented Programming (FOP) is both a design methodology and supporting tools for program synthesis. The goal is to specify a target program in terms of the features that it offers, and to synthesize an efficient program that meets these specifications. FOP has been used successfully to develop product lines in widely varying real-world domains, including compilers for extensible Java dialects, fire support simulators for the U.S. Army, network protocols, and program verification tools.
AHEAD is a simple mathematical model of FOP that is based on step-wise refinement, a methodology for building programs by adding one feature at a time. The incremental units of implementation/design are refinements that encapsulate the implementation of an individual feature. AHEAD models of product lines treat base programs as constants and program refinements as functions (that add a specified feature to the input program). Application designs are thus equations--compositions of functions and constants--that are amenable to optimization and analysis.
This tutorial reviews basic results on FOP, including general models and tools for synthesizing a consistent set of code and non-code artifacts by composing refinements (cross-cuts), automatic algorithms for validating refinement compositions, synthesizing product-lines of product-families (e.g., tool suites), and automatic algorithms for optimizing application designs (equations).
Attendee background
Prerequisites: Participants should understand basic concepts of object orientation, but no other special background is necessary.
Don Batory holds the David Bruton Centennial Professorship at The University of Texas at Austin. He received a B.S. (1975) and M.Sc. (1977) degrees from Case Institute of Technology, and a Ph.D. (1980) from the University of Toronto. He was a faculty member at the University of Florida in 1981 before he joined the Department of Computer Sciences at the University of Texas in 1983.
He was an Associate Editor of IEEE Transactions on Software Engineering (1999-2002), Associate Editor of ACM Transactions on Database Systems (1986-1992), a member of the ACM Software Systems Award Committee (1989-1993; Committee Chairman in 1992), Program Co-Chair for the 2002 Generative Programming and Component Engineering Conference, the Program Chair for the 1995 International Conference on Software Reuse, and the 1999 Workshop on Software Reuse. He has given numerous lectures and tutorials on product-line architectures, generators, and reuse, and is an industry consultant on product lines.
Program generation has been used for a long time to facilitate the development of enterprise and embedded systems. More recently, its potential for improving object-oriented software development in general has been realized through the use of program generation techniques such as generative programming, product line engineering, and model-driven architectures (MDA).
This tutorial introduces the most important kinds of code generation, such as model transformations, source code generation, source code transformation, byte code rewriting and reflection. We will introduce different code generation technologies, such as template-based generators, frame technology, aspect weaving and AST-based approaches; illustrate when to use them; discuss benefits and drawbacks of each approach; and look at representative tools that support each kind of program generation. Some of these tools will also be demonstrated.
Attendee background
Prerequisites: Attendees should be experienced OO developers or architects and must understand an OO programming language, such as Java, C++ or C#. Familiarity with UML is also required. Previous experience with code generation is not necessary.
Lecture and live demonstrations
Markus works as an independent consultant in software technology and engineering. He focuses on the architecture of large, distributed systems. Markus is the author of several magazine articles and patterns, a regular speaker at conferences, and co-author of Wiley's "Server Component Patterns." Over the last couple of years, Markus has architected and implemented several large enterprise systems in banking, diagnostics and automotive, on various scales. He has used code generation in the context of enterprise and embedded systems. Markus can be reached at email@example.com or via http://www.voelter.de.
The Generative Model Transformer (GMT) project is an Open Source initiative to build a Model Driven Architecture™ tool that allows fully customisable Platform Independent Models, Platform Description Models, Mappings, and Refinement Transformations. The project should result in:
GMT resides as a technology project on Eclipse.org.
The demo intends to show the state of the tool at the time of OOPSLA.
The software is designed using UML modeling and implemented using generative techniques. It will be implemented mainly in Java. Links will be provided to other existing tools that can fill in some of the functionality required.
GMT will provide a related set of components that can be used by other MDA tool components, and will consist of four main components:
MetaEdit+ is an environment that allows building modeling tools and generators fitting to application domains, without having to write a single line of code. The capability to define modeling tools and generators is relevant as it provides the ability to raise the abstraction of design work from code to domain concepts, and a raise in abstraction leads to an imminent raise in productivity, as illustrated by the past years' experiences.
In domain-specific modeling and MetaEdit+, one expert defines a domain-specific language as a metamodel containing the domain concepts and rules, and specifies the mapping from that to code in a domain-specific code generator. For the method implementation, MetaEdit+ provides a metamodeling language and tool suite for defining the method concepts, their properties, associated rules, symbols, checking reports, and generators.
Once the expert defines a modeling method, or even a partial prototype, the rest of the team can start to use it in MetaEdit+ to make models with the modeling language and the required code is automatically generated from those models. Based on the metamodel, MetaEdit+ automatically provides CASE tool functionality: diagramming editors, browsers, generators, multi-user/project/platform support, etc. MetaEdit+ is implemented in Smalltalk.
The MetaEdit+ demo will focus on showing how the domain-specific languages and generators are made; complete with several examples of domain-specific methods and related code generators.
Keywords: metamodel; domain-specific modeling languages; code generators
In most business software systems the time dimension of business objects plays a significant role. Time is a crosscutting concern that is hard to separate from other business logic. We have developed a toolkit that allows existing business application systems to be extended with "time-conscious" behavior in a non-intrusive way by factoring out all aspects of time-related behavior into a framework and a set of classes that is distinct from the existing code base. The Time Conscious Objects™ (TCO) toolkit is currently implemented in Java™, but through the use of generation technology the toolkit can easily be made available in any language that supports polymorphism.
The TCO toolkit has been explicitly designed to allow non-intrusive and incremental integration into existing systems. Time-conscious objects can have a major impact on the quality and maintainability of applications by eliminating the complexity of dealing with the time dimension. This is the case for example in time-based billing systems, in the insurance industry, and in the modeling of "parts" in ERP and manufacturing systems.
The demonstration provides an overview of the architecture and the APIs that TCO uses to integrate with existing application system environments. Beyond that, the demonstration shows on the basis of one or more small example applications, how TCO can be used to raise the level of abstraction in platform independent models and in business application code.
TCO product development is work-in-progress and the demonstration is intended to be highly interactive, giving the audience opportunity to raise and discuss their specific time-dimension-related requirements.
Software for embedded systems faces some special constraints not found in other domains. One of these constraints is a hard limitation on available RAM/ROM, processing power, and other resources. To cope with these limitations without losing the reusability of the software components, product line technologies are a promising approach. However, adequate tools for variant management are still rare.
In the demonstration we will apply Pure::Consul, a tool which supports the description of problem and solution domains of product lines, software families, or other variable artifacts in a highly flexible manner, to a realistic application scenario: a weather station product line running on a small 8 bit microcontroller with only a few KBytes of memory.
Problem domain modeling with Pure::Consul is based on extended feature models. The tool allows for integration of many different variability realization techniques through its customizable transformation backend. Thus, it is able to incorporate frame processors, code generators, or arbitrary other tools.
The implementation of the presented product line is based on AspectC++, an aspect-oriented extension to C++. We will demonstrate that by applying aspect-oriented software development, the number of configuration points in the code can be reduced. Both tools together form an ideal tool chain for embedded software product line development as one reduces the configuration complexity on the source code level, while the other helps to manage the variability on the abstract feature level and provides a mapping of features to aspects, classes, or other modularization units.
Model Driven Architecture (MDA) is a technology that has been in the process of evolution for many years. Today, many vendors are now producing products that support MDA. We are hearing more and more success stories that indicate that this technology is the "real deal". But, with the failed promises of CASE in the late 1980's, many people still have questions about how much of an application can be generated from models and constraint languages. Is MDA really capable of generating enterprise applications? What are the technologies are available to implement MDA? Here is your opportunity to ask the experts the questions that are necessary to convince you of the validity of this new technology. Each of these panelists has been intricately involved in building the underlying foundations of Model Driven Architecture and its implementation.
Today, application development remains a laborious process, with relatively little reuse or automation. Application programmers must manually map their high-level analysis models to target platform architectures, such as J2EE and .NET, and eventually, to code. Rather than focusing on the problem domain, they have to deal with the complex details of the target platforms. The analysis and design models - being just additional documentation artifacts - are often not properly maintained in the face of approaching deadlines. This makes the applications hard to evolve later. Retargeting an application to a new platform is almost as difficult as writing it from scratch. Model-Driven Architecture (MDA) is a framework for model-based development being standardized by the Object Management Group (OMG) that addresses these problems. In MDA, models are the primary source of an application. All other artifacts, such as code, tests, and documentation, are (mostly) automatically derived from models.
In this tutorial, we will take a critical look at the promises made by MDA and clearly distinguish what is possible today from the visions of tomorrow. After explaining basic MDA concepts, such as metamodeling and model transformations, we'll discuss tool requirements and review some existing MDA tools. We'll round up the tutorial with a demonstration of generating a complete J2EE and .NET application from the same high-level UML model.
Attendee background
Prerequisites: Attendees should have basic knowledge of UML.
Lectures and demonstrations
Dr. Krzysztof Czarnecki is an Assistant Professor at the University of Waterloo, Canada. Before coming to Waterloo, he spent 8 years at DaimlerChrysler Research working on the practical applications of generative programming (GP). He is co-author of the book "Generative Programming" (Addison-Wesley, 2000), which is regarded as seminal work of the area and is used as a graduate text at universities around the world. He is General Chair of the 2003 International Conference on Generative Programming and Component Engineering (GPCE). His current research focuses on realizing the synergies between GP and model-driven architectures.
Petter Graff is Vice President of InferData Corporation. He has developed object-oriented systems for more than 20 years. At InferData, his focus is in object-oriented component development, software architectures and advanced implementation techniques for enterprise applications. He created one of the first model transformation tools (MCC) and is currently responsible for the development of InferData's next generation agent-based model transformation tool. Petter is also coauthoring an upcoming book on Model Driven Development (estimated to be published fall 2003).


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Financial Planning for Football Clubs
Planning what you want to do in your club is an important part of making it a success.
A business plan is your roadmap, guiding the direction your business takes, and helping to keep you on track and measure your success.
This Business Wales website can help you produce a plan template and takes you step-by-step through the process.CLICK HERE FOR MORE
Sign up now
To get access to the latest FAW Trust news, courses and coaching.


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The "modern" era of hepatitis C virus (HCV) treatment began in 2014 with FDA approval of the direct acting antiviral agent (DAA) Harvoni for use in HCV monoinfected patients. Since then, the FDA-approved indication of Harvoni has been expanded to include the HCV/HIV co-infected population and the FDA has approved 5 more DAAs or combinations of DAAs.
Treatment Regimens Target Proteins
The development of multiple DAAs, which target specific steps within the HCV life cycle, has been facilitated by knowledge of the HCV genome and proteins. The current treatment regimens target proteins that are involved in HCV replication and assembly, such as NS3/4A protease, NS5B polymerase, and the NS5A protein. Combination therapy is used to optimize HCV treatment response rates and reduce the likelihood of developing treatment-emergent resistance-associated variants.
Following are the 4 classes of DAAs:
1. NS3/4A protease inhibitors: grazoprevir (a component of Zepatier™), paritaprevir (a component of Technivie™ and Viekira Pak™), and simeprevir (Olysio™).
2. NS5A inhibitors: daclatasvir (Daklinza™), elbasvir (a component of Zepatier™), ledipasvir (a component of Harvoni™), ombitasvir (a component of Technivie™ and Viekira Pak™), and velpatasvir (a component of Epclusa™).
3. NS5B nucleot(s)ide polymerase inhibitors: sofosbuvir (Solvaldi™ and a component of Harvoni™).
4. NS5B non-nucleoside polymerase inhibitors: dasabuvir (a component of Viekira Pak™).
Compensated or Decompensated Cirrhosis?
Duration of treatment is based on genotype, prior treatment history, and the presence of compensated or decompensated cirrhosis. These types of cirrhosis may be distinguished by noting that persons with compensated cirrhosis do not have hepatic encephalopathy, ascites, variceal bleeding, or jaundice. Treatment of patients with decompensated cirrhosis or those with hepatocellular carcinoma should be deferred to a specialist.
Persons who are co-infected with HIV and hepatitis B virus probably should be referred to an infectious diseases specialist or to a hepatologist.
Next: Currently Approved Treatment Regimens
American Association for the Study of Liver Diseases and Infectious Diseases Society of America. Recommendations for Testing, Managing, and Treating Hepatitis C.


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According to Nike trainer Alex Silver-Fagan, squats are the best way to get your buttocks and legs in shape. Squats can be done on their own, but they work even better when combined with other exercises. They are pretty simple to perform at home and won't take much of your free time.
Here's a week-long training plan including variations of squats that will help you get in form just in time for summer:
Basic Squat
Start the program with basic squats. When doing them, make sure your feet are flat on the ground.
Squats With Kickbacks
The kickbacks will really engage your buttock muscles and shape it.
Sumo Squats
These squats will reinforce your buttocks, legs and torso as well.
Reaching Sumo Squats
They are similar to the sumo squats but add cardio in the equation.
Oblique Squats
The oblique squats will reduce your waist size.
Jump Squats
This exercise will tone your arms and other muscles as well.
Narrow Squats
These squats are a warm up to pistol squats.
Pistol Squats
The so-called pistol squats are a bit tougher than the rest of the program and require a lot of knee work. When starting, hold on to something and make sure you're not going too low.
Curtsey Squats
The curtsey squats will engage and tone many muscle groups.
Split Squats
These squats will target your hips, buttocks and calves.
Isometric Squats With Toe Taps
According to Silver-Fagan, this exercise will burn fat from your booty and tighten those muscles.
Pop Squats
This exercise will help your muscles rest and flush out the lactic acid from your muscles.
Here's the plan for the whole week:


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Bronze Packageup to 4 hours
- Our Bronze package will cover your ceremony only. We will arrive 30 minutes before and look to leave 30-60 minutes after. During this time we will both be on hand to capture pictures of your guests as they arrive, along with the groom and best man, and of course the bridal party as they arrive.
- One of us will photograph the ceremony from the front whilst the other will be at the back, ensuring all angles are covered.
- After the ceremony we will take any posed shots required, along with confetti and group shots, and of course lots of natural shots too.
- You get a USB drive with your high-resolution images on
Silver Package4 - 6 hours
- As Bronze package but also including EITHER getting ready shots OR reception pictures
Gold Package6 - 8 hours
- As Silver package but can be flexible, i.e. could include getting ready shots, ceremony and reception, or ceremony, reception and evening up to 1st dance
Platimum8 - 10 hours
- As Gold package and usually sufficient time to cover your whole day, from getting ready to 1st dance
Platinum Plus Package10 hours plus
- This ultimate package will ensure nothing from your day will be missed and will tell the full story of your day.
- We will be with you for both Bride and Groom getting ready shots, the ceremony, reception and evening reception right up to the 1st dance
Photo Printing
We offer a photo printing service, whether you want your images printed on quality photographic paper or onto canvas. Please get in touch with us for a competitive quote.
Photo Book – variable cost
We can prepare a photo book for you.
The choice of which pictures you have in your album will be yours. We will discuss with you any preferences eg gloss or matte, lay flat pages, full page pictures, cover pictures etc, and will then do everything else for you.
As a guide only, a 48 page photo book will cost in the region of £150, which will include our fee of £100. The less pages or extras you have, the cheaper it will be and vice versa. Get in touch for more details.


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Observatory at a glance
Named after the historic Royal Observatory, the area is now home to the South African Astronomical Observatory headquarters which sits comfortably beside the South African National Circus School and famous Groote Schuur Hospital where the world's first heart transplant took place.
Observatory offers the perfect lifestyle to anyone seeking to become part of a warm and spirited community. Regarded by many as Cape Town's creative hub, trendy "Obs", as it is affectionately known, is a rich and vibrant neighbourhood characterised by a creative and bohemian community. The social hub on Lower Main Road presents an energetic blend of lively restaurants and eclectic bars, laid-back meeting places and quirky shops, bookstores and art galleries.
At nearby St Peter's Square Mall several retail shops and businesses are located in one convenient location.
Disclaimer: While every effort will be made to ensure that the information contained within the Berman Brothers website is accurate and up to date, Berman Brothers makes no warranty, representation or undertaking whether expressed or implied, nor do we assume any legal liability, whether direct or indirect, or responsibility for the accuracy, completeness, or usefulness of any information. Prospective purchasers and tenants should make their own enquiries to verify the information contained herein.


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There are lots of reasons as to why you should choose a bus charter for their needs in transportation
This may include things like sports team transportations on the street, higher school trips, family functions Such as reunions and weddings and even excursions for seniors. There are many different reasons as to why you may need such services. Choosing the ideal bus charter isn't a simple thing, but a thing that needs to be produced by the group leader. There are many bus charter businesses that it is possible to select but you have to compare these to end up with just the very best.
Among the most important mistakes that we make is calling for a company and getting a quote
In most cases, people end up selecting the company that has the lowest porkies without contemplating very important facets. As much as the price is an important aspect, particularly with the economy, there are others like the condition of the bus, the condition of the driver, the dependability of the company and the safety of the bus. Other items to be considered include
- Contracts
- Cancellations
- Usage
Accepting an interest in each of the facets can help save a great deal of headaches throughout your tour.
Physical affirmation
You have to ask the company to let you see the bus that they're offering for charter. Most companies will have a website at which buses are on screen. You should take the time to observe the buses physically to guarantee that they're really what exactly are on the website. Ensure that they're in good shape. Check the:
- Tires
- The windshields
- Other items about the bus
Do not concentrate too much on age, more about the condition. Ensure that the bus has certificate and has been serviced recently.
Satisfied customers
This is just another way of finding the very best bus charter. When they have a great record of achievement of customers who are satisfied, they should do just fine. You should go to the website and look at the testimonials. It is also possible to request some references. Find out how breakdowns are handled. Being a member of any professional associations or other businesses can guarantee that they're indeed in a good place to handle any eventualities. You may ask about any previous incidence and how it had been treated.
The driver
He/she is an important part of the bus charter encounter. They ought to be educated, friendly and as professional as you can in all the coach operations. You ought to get a driver that will match the group. By way of example, if it is a group with school-age passengers, be sure that the driver isn't grumpy and that he loves being around children and so forth.
Price is also significant. Bus businesses tend to fight with the economy just like the other business. Find out what is significant to you and when the purchase price makes any difference in any way. If you search the internet, make certain you are handling a bus charter company right and not a broker. Do not settle for the first result you run into.


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Ford Castle is a real medieval castle near Berwick upon Tweed, in the Northumberland countryside. A historical site, we are located near to the Tweed River, close to the market town of Berwick and not far from the city of Newcastle upon Tyne.
The castle itself has been around for centuries, and is nestled in the picturesque northern English countryside, at the foot of the Cheviot Hills and close to the Scottish border. We have huge private grounds and on-site adventure activities;ours is a camp like no other, and a beautiful place to stay.
We are close to the A1 motorway, so we have easy access to international airports in Newcastle and Edinburgh to collect our young visitors, and run day trips to loads of exciting places throughout their stay.


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Guest artists Cammie Griffin, Randi Strong, Matt Mixon and B-Free bring their talent to Kintsugi
May 10, 2019
Each year we invite guest artists to help us create the art for our annual performance and to participate onstage as well. This year we were fortunate enough to have the talent of:
- Cammie Griffin, dancer, choreographer, member of STOMP! and long-time friend to Express Yourself Milwaukee. In fact, 2019 is her eleventh show with us!
- Randi Strong, dancer and choreographer who is best known for being a Top 5 Female Dancer on Season 5 of "So You Think You Can Dance" and the accompanying 40 city national arena tour.
- Matt Mixon, filmmaker and director, who worked with Express Yourself Milwaukee youth in detention to create an especially moving short film that played near the end of the stage show, and
- B-Free, singer, instrumentalist, composer and producer (and aka Britney Freeman-Farr), who performed with our house band and led our final number, "Livin' My Life Like It's Golden."
Guest artists add richness and texture to the show and also offer youth additional ways of envisioning their future. We're grateful to Cammie, Randi, Matt, and B-Free for sharing their gifts with us this year.


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This session, oh goodness, so many heart flutters. A beautiful day from start to sunset, beautiful details including this gorgeous dip dyed wedding skirt, a beautiful couple inside and out, and such a beautiful love. I feel so lucky to get to photograph this kind of connection time and time again.
Bride + Groom: Allie + Weston
Skirt/Top: Sweet Caroline Styles
HMUA: Hannah Elisabeth Beauty
Florals: Kristin Smith Floral Concepts


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Fight Aging! Newsletter, November 5th 2012
November 5th 2012
The Fight Aging! Newsletter is a weekly email containing news, opinions, and happenings for people interested in aging science and engineered longevity: making use of diet, lifestyle choices, technology, and proven medical advances to live healthy, longer lives. This newsletter is published under the Creative Commons Attribution 3.0 license. In short, this means that you are encouraged to republish and rewrite it in any way you see fit, the only requirements being that you provide attribution and a link to Fight Aging!
- Considering Strategy in Aging Research
- A Review of "The Singularity"
- Not All Longevity Manipulations Play Nice Together
- A Possible Metabolic Signature of Biological Age in Mice
- Discussion
- Latest Headlines from Fight Aging!
- Investigating the Mechanisms of Cellular Senescence
- Creating Myelin-Producing Cells to Order
- Promoting Remyelination by Blocking Hyaluronidase
- Deepening the Puzzle
- Considering Antagonistic Pleiotropy
- More Mitochondrially Targeted Antioxidant Results
- Exercise Improves Cognitive Function
- Cartilage From Induced Pluripotent Stem Cells
- Commenting on the Utility of AGE-Breakers
- Histone Deacetylase Inhibitors Preserve Function in Aging Axons
The research community has as many opinions as researchers when it comes to how best to proceed with lengthening healthy human life spans. There are some clearly identifiable camps, however, such as slowing aging by manipulating metabolism versus reversing aging by repairing the damage that causes degeneration. Here are some thoughts on these camps and some of their subdivisions from Aubrey de Grey of the SENS Foundation:
The September 2012 issue of Scientific American includes a commentary contrasting two approaches to combating aging. Like almost all general-audience piece, and despite the best efforts of most experts in the field, it highlights the goal of life extension rather than stressing that any longevity benefits will be a side effect of health benefits ... The value of the article, though diminished thereby, is still substantial, in that it provides a clear description of the contrast between the "combat one disease at a time" approach generally taken by geriatricians and the holistic "combat aging itself" approach favored by most biogerontologists.
As those readers familiar with my work will know, I view both such approaches as highly unlikely to deliver substantial postponement of age-related ill health in the remotely foreseeable future, but not for the reasons generally given by the proponents of the other approach. Geriatricians reject combating of "aging itself" because they don't generally view aging as a medical condition at all, but instead merely view chronological age as a risk factor for various types of ill health. Biogerontologists, conversely, reject the "one disease at a time" approach because they believe that there will always be something - the very same "aging itself," of course - that will be a source of exponentially accelerating ill health however many specifics are defeated.
The SENS perspective is that it is inaccurate and misleading to draw a sharp distinction between "aging itself" and the specific aspects of age-related ill health, first because where one draws that distinction is arbitrary - Are foam cells atherosclerosis yet, for example? Are fatty streaks? - and second because the lifelong changes that drive ill health, and thus hold the the only logical claim to be lumped under the term "aging," are themselves not aspects of any meaningful unitary process, but are instead relatively independent processes occurring as side-effects of different aspects of metabolism.
A documentary film entitled The Singularity is the latest in a line of works from recent years to examine the near future of technology and its implications: a convergence of biotechnology, ever-increasing computing power, and molecular nanotechnology means that we will become capable of engineering ourselves to much the same degree as we presently choose to engineer our surroundings. Why would we stick with the flaky, error-prone, and short-lived evolved version of human biology when far better and more cost-effective replacements can be built? Here is a short review:
Doug Wolens' latest documentary captures the argument between the two sides. The Singularity takes the form of a series of intercut interviews, with animations illustrating various points ... Wolens' subjects include, unsurprisingly, people like Kurzweil himself, roboticist Cynthia Breazeal, and gerontologist Aubrey de Grey. But Wolens also interviews people not normally associated with the speculative edge of artificial intelligence and biomolecular engineering, such as Richard A. Clarke, the former chief counterterrorism advisor to the U.S. National Security Council, and the current U.S. secretary of defense, Leon Panetta.
While The Singularity doesn't cover a great deal of ground that's new to anyone already familiar with the concept, it does provide crisp snapshots of the current state of the debate and many of the main players.
One of the pleasant aspects of the repair approach to intervention in aging, such as that proposed in the Strategies for Engineered Negligible Senescence (SENS), is that all distinct forms of repair therapy can reasonably be expected to complement one another. Undergo a procedure to fix mitochondrial damage or break down an AGE such as glucospane, for example, and you are better off. Undergo both therapies and you will gain a commensurately greater benefit.
Unfortunately, this expectation of complementary therapies is very much not the case when it comes to attempts to slow down aging by genetic, epigenetic, or other metabolic manipulation. Metabolism is enormously complex, and even the well-studied phenomenon of calorie restriction isn't yet fully understood in terms of how the machinery of genes, proteins, and controlling signals all ties together to increase life span and improve health. Varied methods of extending life by slowing aging often turn out to operate on different portions of the same mechanism, or to be harmful when used together even though they are beneficial on their own.
One thing often tried by research groups that discover a novel way of slowing aging in laboratory animals is to try out the new method in calorie restricted animals: will the effects on life span complement one another and thus lead to a greater extension of life than is the case for either method on its own? Few presently known genetic alterations or other methods of slowing aging produce more than a 30% life extension in mice, and the standing record is 60-70% for growth hormone deficient mice - so at this point in time, it seems unlikely that any new life span record will be set through slowing aging without employing some complementary combination of techniques.
That this hasn't yet happened suggests that we shouldn't hold out much hope for the next five to seven years - there has, after all, been a lot of experimentation in mice over the past decade, and especially since the record set using growth hormone deficient mice. Unfortunately purely negative results don't tend to be published as often as positive results, so it's not a straightforward matter to find out which combinations of the various known methods to slow aging in mice have been tried only to fail.
A low-cost, reliable method of measuring biological age is greatly sought after by the research community. People and laboratory animals age at different rates - by which I mean that they accumulate damage and changes characteristic of aging at different rates. Thus two individuals of the same species and same chronological age might have different biological ages thanks to life style, environment, access to medicine, and so forth.
Some interventions, such as calorie restriction, can slow the pace at which an individual ages, but measuring this slowing is a challenging process. Biological age is a simple concept at the high level, but finding a quick and reliable way to actually measure it has yet to happen. Thus while researchers would like to have rapid answers as to how effective any given method of slowing aging might be, they must wait and run long-lasting studies. The bottom line measure for any slowing of aging is to wait for the individuals in question to live out their lives and thus measure by effect on life span. Even in short-lived mice this can require years and thus a great deal of money. In longer-lived animals, ourselves included, it is simply impractical to run the necessary studies.
When it comes to the forthcoming generation of therapies capable of limited rejuvenation - by repairing some of the damage that causes degenerative aging - the situation is much the same, as is the need for a quick and easy measure of biological age. A therapy that actually produces some degree of rejuvenation should make a laboratory animal biologically younger than peers with the same chronological age. But how to measure that change without employing the lengthy and expensive wait-and-see approach?
Given the present state of affairs, any quick measure of biological age will speed research, making it very much faster and cheaper to assess varied means of extending healthy life. Some experiments that would presently require a year or more could be conducted in a few weeks or months: apply the therapy and evaluate the resulting changes in measures of biological age.
Several lines of research look promising when it comes to yielding a way to reliably and consistently evaluate biological age. One involves measurement of DNA methylation levels, and despite initial setbacks it may yet prove possible to tease out a useful measure from changes in the dynamics of telomere length. There are others. Here, for example, is a recent paper in which researchers present a method based on measurement of metabolite levels.
The highlights and headlines from the past week follow below. Remember - if you like this newsletter, the chances are that your friends will find it useful too. Forward it on, or post a copy to your favorite online communities. Encourage the people you know to pitch in and make a difference to the future of health and longevity!
Friday, November 2, 2012
Senescent cells are those that have left the cell cycle without being destroyed, either by the immune system or by one of the processes of programmed cell death. They remain active, however, exhibiting what is termed a senescence-associated secretory phenotype (SASP): these cells secrete all sorts of chemical signals that prove harmful to surrounding tissues and the body as a whole - through promotion of chronic inflammation, for example. The number of senescent cells in tissue grows with age, and this increase in numbers is one of the root causes of aging. Researchers have demonstrated benefits in mice through destroying senescent cells without harming other cells. Regular targeted destruction of senescent cells could be the basis for therapies that remove this contribution to degenerative aging. Any other approach would require understanding more about SASP and how to control or reverse the unpleasant effects of senescence - and here is an example of this sort of research, aimed at identifying controlling mechanisms with an eye to building therapies to reduce SASP: "With advancing age, senescent cells accumulate in tissues and the SASP-elicited proinflammatory state is believed to have a complex influence on age-related conditions. For example, two major SASP factors, IL-6 and IL-8, together with other SASP factors, attract immune cells to the tissue in which senescent cells reside; depending on the tissue context, this immune surveillance can promote processes such as wound healing, the resolution of fibrosis, and tumor regression. At the same time, SASP factors can compromise the integrity of the ECM, thus facilitating cancer cell migration. In addition, the systemic proinflammatory phenotype seen in the elderly is believed to affect a broad range of age-related pathologies, including diabetes, cancer, neurodegeneration and cardiovascular disease and contributes to an age-related decline of the adaptive immune system (immunosenescence). Despite the great potential impact of the SASP on the biology of senescence and aging, the mechanisms that regulate SASP are poorly understood. ... Here, we report the identification of NF90 as an RNA-binding protein that binds to numerous mRNAs encoding SASP factors (collectively named SASP mRNAs) and coordinately influences their post-transcriptional fate in a senescence-dependent manner. In young, early-passage, proliferating fibroblasts, high NF90 levels contributed to the repression of SASP factor production. This repression was elicited mainly via reduction in SASP factor translation ... By contrast, in senescent cells NF90 levels were markedly reduced, which allowed increased expression of numerous SASP factors. Our results are consistent with a role for NF90 as a coordinator of the inhibition of SASP factor production in early-passage, proliferating fibroblasts; in senescent cells, the lower levels of NF90 lead to SASP de-repression, permitting higher expression of SASP factors"
Friday, November 2, 2012
Myelin sheaths the axons of nerve cells, but the integrity of this sheathing degrades with age. Transplants of neural stem cells can be used to encourage myelin formation, and researchers are exploring this approach as a therapy for conditions involving more profound myelin loss. There is always a demand in this sort of research for better and cheaper ways to obtain cells that have the desired effect. It is not trivial, for example, to isolate the right sort of neural stem cell, or establish a protocol for producing these cells from embryonic or induced pluripotent stem cells. A great deal of stem cell research these days involves the discovery of chemical signals, growth environments, and other necessary items to guide the growth of specific cell types. Here is an example for myelin-forming cells, which will no doubt contribute to the next round of research and development of cell therapies aimed at regrowth of myelin: "Researchers have unlocked the complex cellular mechanics that instruct specific brain cells to continue to divide. This discovery overcomes a significant technical hurdle to potential human stem cell therapies; ensuring that an abundant supply of cells is available to study and ultimately treat people with diseases. "One of the major factors that will determine the viability of stem cell therapies is access to a safe and reliable supply of cells. This study demonstrates that - in the case of certain populations of brain cells - we now understand the cell biology and the mechanisms necessary to control cell division and generate an almost endless supply of cells." The study focuses on cells called glial progenitor cells (GPCs) that are found in the white matter of the human brain. These stem cells give rise to two cells found in the central nervous system: oligodendrocytes, which produce myelin, the fatty tissue that insulates the connections between cells; and astrocytes, cells that are critical to the health and signaling function of oligodendrocytes as well as neurons. One of the barriers to moving forward with human treatments for myelin disease has been the difficulty of creating a plentiful supply of necessary cells, in this case GPCs. Scientists have been successful at getting these cells to divide and multiply in the lab, but only for limited periods of time, resulting in the generation of limited numbers of usable cells. ... Overcoming this problem required that [researchers] master the precise chemical symphony that occurs within stem cells, and which instructs them when to divide and multiply, and when to stop this process and become oligodendrocytes and astrocytes."
Thursday, November 1, 2012
Myelin is the material sheathing axons in nerve cells. A number of conditions involve loss of myelin, such as multiple sclerosis (MS), but loss of myelin integrity occurs to a lesser degree for all of us as we age, and is thought to contribute to the characteristic cognitive decline of later years. Thus research into ways to regenerate myelin sheathing has broad potential application and is worth keeping an eye on: "We have identified a whole new target for drugs that might promote repair of the damaged brain in any disorder in which demyelination occurs. Any kind of therapy that can promote remyelination could be an absolute life-changer for the millions of people suffering from MS and other related disorders. In 2005, [researchers] discovered that a sugar molecule, called hyaluronic acid, accumulates in areas of damage in the brains of humans and animals with demyelinating brain and spinal cord lesions. Their findings at the time [suggested] that hyaluronic acid itself prevented remyelination by preventing cells that form myelin from differentiating in areas of brain damage. The new study shows that the hyaluronic acid itself does not prevent the differentiation of myelin-forming cells. Rather, breakdown products generated by a specific enzyme that chews up hyaluronic acid - called a hyaluronidase - contribute to the remyelination failure. This enzyme is highly elevated in MS patient brain lesions and in the nervous systems of animals with an MS-like disease. The research team [found] that by blocking hyaluronidase activity, they could promote myelin-forming cell differentiation and remyelination in the mice with the MS-like disease. Most significantly, the drug that blocked hyaluronidase activity led to improved nerve cell function. The next step is to develop drugs that specifically target this enzyme."
Thursday, November 1, 2012
One of the many oddities in the way in which the public at large approaches aging is captured by the existence of a thriving "anti-aging" marketplace, full of people selling fake silver bullets and fraudulent potions, alongside a pervasive lack of interest in scientific research aimed at extending human life, and outright rejection of the goal of extending human life in many quarters. One would think that a market claiming to sell ways to turn back the clock - or at least disguise the fact that the clock is ticking - could not thrive without interest in the supposed goal of their products, yet there is little manifestation of that interest when it comes to actually, really doing something about slowing or reversing aging, rather than just throwing money at faking it. Here is another data point to add to the existence of the "anti-aging" marketplace when trying to understand what is going on here: "A study [finds] that in 2011 spending on medications for aging conditions - such as mental alertness, sexual dysfunction, menopause, aging skin and hair loss - ranked third in annual prescription-drug costs of the commercially insured, surpassed only by the cost of treating diabetes and high cholesterol. The research found that among these insured individuals use of drugs to treat the physical impact associated with normal aging was up 18.5 percent and costs increased nearly 46 percent from 2006 to 2011. Increased use of these drugs was even more pronounced for the Medicare population (age 65+), up 32 percent from 2007 to 2011. The largest utilization jump among Medicare beneficiaries was from 2010 to 2011, up more than 13 percent and outpacing increases in the use of drugs for diabetes, high cholesterol and high blood pressure combined."
Wednesday, October 31, 2012
Antagonistic pleiotropy describes a situation in which a gene provides both benefit and drawback under different circumstances. In evolutionary considerations of aging the usual context for this situation is that a gene is selected because it provides competitive advantages in youth, when reproduction is taking place, and then becomes harmful later in life when evolutionary pressure is much reduced. Here researchers take a measure of the prevalence of this phenomenon in yeast: "The genes responsible for inherited diseases are clearly bad for us, so why hasn't evolution, over time, weeded them out and eliminated them from the human genome altogether? Part of the reason seems to be that genes that can harm us at one stage of our lives are necessary and beneficial to us at other points in our development. [Researchers now] report that antagonistic pleiotropy is very common in yeast, a single-celled organism used by scientists to provide insights about genetics and cell biology. "In any given environment, yeast expresses hundreds of genes that harm rather than benefit the organism, demonstrating widespread antagonistic pleiotropy. The surprising finding is the sheer number of such genes in the yeast genome that have such properties. From our yeast data we can predict that humans should have even more antagonistic pleiotropy than yeast." Yeast has about 6,000 genes, about 1,000 of which are essential - eliminate any of them and the organism dies. [Researchers] worked with a set of 5,000 laboratory strains of yeast in which one non-essential gene had been deleted from each strain. [They] grew all 5,000 strains together in a single test tube and compared the growth rates of each strain. This side-by-side comparison allowed them to determine which genes were beneficial (increased growth rate) and which ones were harmful (decreased growth rate) under the six environmental conditions. The researchers found that for each of the six conditions, on average, the yeasts expressed about 300 genes that slowed their growth and were therefore classified as harmful. Deleting those genes resulted in more rapid growth. But many of the genes that were harmful under one set of environmental conditions proved to be beneficial under another, demonstrating widespread antagonistic pleiotropy."
Wednesday, October 31, 2012
The mitochondria in our cells generate damaging oxidative byproducts as a result of their operation, and that is the first step in a long process that contributes to degenerative aging. Researchers have shown that localizing antioxidants to the mitochondria can reduce this damage and thus modestly slow aging and extend life in laboratory animals. Most antioxidants do not find their way to mitochondria, however, and have no effect on long term health or aging. Thus there has been some interest in recent years in designing compounds that do localize to mitochondria. One research group works on the mitochondrially targeted antioxidant SkQ1 and related compounds, and these scientists continue to conduct a range of studies in laboratory animals: "Here we evaluated the effect of the mitochondria-targeted antioxidant SkQ1 on markers of aging in the old OXYS rats, a unique animal model of accelerated senescence and age-related diseases, as well as normal Wistar rats. ... we compared effects of SkQ1 [on] age-dependent decline in blood levels of leukocytes, growth hormone (GH), insulin-like growth factor-1 (IGF-1), testosterone, dehydroepiandrosterone (DHEA). Our results indicate that when started late in life, treatment with SkQ1 [not] only prevented age-associated hormonal alterations but partially reversed them. These results suggest that supplementation with low doses of SkQ1, even in chronologically and biologically aged subjects seem to be a promising strategy to maintain health and retard the aging process."
Tuesday, October 30, 2012
Following on from a recent post on exercise and the aging brain, here is yet another study to show that improvements in cognitive function can be brought about by regular exercise and its consequent effects on body composition, metabolism, and other line items. Use it or lose it, as they say: "A regular exercise routine can make you fitter than ever - mentally fit. In a new study, previously sedentary adults were put through four months of high-intensity interval training. At the end, their cognitive functions - the ability to think, recall and make quick decisions - had improved significantly. Blood flow to the brain increases during exercise. The more fit you are, the more that increases. The pilot [study] looked at adults, average age 49, who were overweight and inactive. [Researchers] measured their cognitive function with neuropsychological testing, as well as their body composition, blood flow to the brain, cardiac output and their maximum ability to tolerate exercise. The subjects then began a twice-a-week routine with an exercise bike and circuit weight training. After four months - not surprising - their weight, body mass index, fat mass and waist circumference were all significantly lower. Meanwhile, their capacity to exercise (measured by VO2 max) was up 15 per cent. Most exciting, [cognitive function] had also increased, based on follow-up testing. These improvements were proportional to the changes in exercise capacity and body weight. Essentially, the more people could exercise, and the more weight they lost, the sharper they became."
Tuesday, October 30, 2012
Induced pluripotent stem cells (IPSCs) are reprogrammed cells - such as those obtained from a skin sample - and are similar to embryonic stem cells in the sense that it should be possible to generate any form of cell from them. They offer the capacity to easily generate unlimited numbers of patient-specific cells, or build tissue and organ structures from scratch. Each type of tissue or cell requires different chemical instructions, growth environments, and technical strategies to be discovered and then refined, however - and there are a few hundred types of cell in the human body. Here, researchers report on progress on generating cartilage from IPSCs: "[Researchers have] engineered cartilage from induced pluripotent stem cells that were successfully grown and sorted for use in tissue repair and studies into cartilage injury and osteoarthritis. ... [This] suggests that induced pluripotent stem cells, or iPSCs, may be a viable source of patient-specific articular cartilage tissue. Articular cartilage is the shock absorber tissue in joints that makes it possible to walk, climb stairs, jump and perform daily activities without pain. But ordinary wear-and-tear or an injury can diminish its effectiveness and progress to osteoarthritis. Because articular cartilage has a poor capacity for repair, damage and osteoarthritis are leading causes of impairment in older people and often requires joint replacement. One challenge the researchers sought to overcome was developing a uniformly differentiated population of chondrocytes, cells that produce collagen and maintain cartilage, while culling other types of cells that the powerful iPSCs could form. To achieve that, the researchers induced chondrocyte differentiation in iPSCs derived from adult mouse fibroblasts by treating cultures with a growth medium. They also tailored the cells to express green fluorescent protein only when the cells successfully became chondrocytes. As the iPSCs differentiated, the chondrocyte cells that glowed with the green fluorescent protein were easily identified and sorted from the undesired cells. The tailored cells also produced greater amounts of cartilage components, including collagen, and showed the characteristic stiffness of native cartilage, suggesting they would work well repairing cartilage defects in the body."
Monday, October 29, 2012
Advanced glycation endproducts (AGEs) are a class of undesirable metabolic byproduct. The level of AGEs in the body rises with age and causes harm through a variety of mechanisms, such as by excessively triggering certain cellular receptors or gluing together pieces of protein machinery by forming crosslinks, thus preventing them from carrying out their proper function. In past years a number of efforts were undertaken to develop drugs that can safely break down at least some forms of AGE. Early promising candidates in laboratory animals failed in humans because the most harmful forms of AGE are different for short-lived versus long-lived mammals - so what benefits a rat isn't of much utility for we humans. So far little progress has been made towards a therapy for the dominant type of AGE in humans, glucosepane, sad to say, as there is comparatively little interest in this field of research. Here is a recent paper commenting on the potential utility of AGE-beaker drugs: "Reducing sugars can react nonenzymatically with the amino groups of proteins to form Amadori products. These early glycation products undergo further complex reactions, such as rearrangement, dehydration, and condensation, to become irreversibly cross-linked, heterogeneous fluorescent derivatives, termed advanced glycation end products (AGEs). The formation and accumulation of AGEs have been known to progress in a normal aging process and at an accelerated rate under diabetes. Nonenzymatic glycation and cross-linking of proteins not only leads to an increase in vascular and myocardial stiffness, but also deteriorates structural integrity and physiological function of multiple organ systems. Furthermore, there is accumulating evidence that interaction of AGEs with a cell-surface receptor, receptor for AGEs (RAGE), elicits oxidative stress generation and subsequently evokes inflammatory, thrombogenic, and fibrotic reactions, thereby being involved in atherosclerosis, diabetic microvascular complications, erectile dysfunction, and pancreatic β-cell apoptosis. Recently, AGE cross-link breakers have been discovered. Therefore, removal of the preexisting AGEs by the breakers has emerged as a novel therapeutic approach to various types of diseases that develop with aging. This article summarizes the potential clinical utility of AGE cross-link breakers in the prevention and management of age- and diabetes-associated disorders."
Monday, October 29, 2012
Epigenetics has become an important component of the study of aging: how genetic regulation changes in response to cellular and molecular damage. One of the mechanisms of this regulation is the acetylation of histones: researchers evaluate the way in which this changes with aging, leading to changes in gene expression, altered levels of key protein machinery in tissues, and changes in the operation of biological systems in the body. Some research groups are in search of epigenetic alterations that might be reversed through therapy to produce beneficial effects: "Aging increases the vulnerability of aging white matter to ischemic injury. Histone deacetylase (HDAC) inhibitors preserve young adult white matter structure and function during ischemia by conserving ATP and reducing excitotoxicity. In isolated optic nerve from 12-month-old mice, deprived of oxygen and glucose, we show that pan- and Class I-specific HDAC inhibitors promote functional recovery of axons. This protection correlates with preservation of axonal mitochondria. The cellular expression of HDAC 3 in the central nervous system (CNS), and HDAC 2 in optic nerve considerably changed with age, expanding to more cytoplasmic domains from nuclear compartments, suggesting that changes in glial cell protein acetylation may confer protection to aging axons. Our results indicate that manipulation of HDAC activities in glial cells may have a universal potential for stroke therapy across age groups."


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What do a former navy reservist, a one-time sportswriter, and a Brit with creaky joints have in common? They're the hottest pop stars who should be on constant shuffle this season
Has EDM had a bigger year than 2014? Whether it was Arcade Fire's Win Butler shit-talking the genre's artists, the over-saturation of electronic-oriented music festivals, Daft Punk taking home the Grammy for Album of the Year in January, or—hell—Lil Jon's EDM-biting anthem getting used in a PSA for Rock the Vote this month, "Electronic Dance Music" (as it's misleadingly titled) is the sound that's undeniably defined the year. But what goes up must come down—that high from Electric Daisy included. Still, there are batch of artists who are crafting compelling electronic sounds that fall outside of the whole wub-wub-wub terrain. Here are 13 to check out.
From rock anthems to woozy hip-hop to pop-steeped merengue (seriously!), the must-hear tracks of the season
From Beyonce's insanely sexy show-opener to Pharrell's insane hat, we're handing out our own awards for the 2014 telecast
Snubs! Tone-deaf collaborations! Kanye rants! Certain elements of Music's Biggest Night are as predictable as Taylor Swift cleaning up (and dancing awkwardly in the aisles). Here are thirteen sure-shots for this year's telecast.
Miley wrecked it, Daft Punk got lucky, Gaga got applause and Beyonce shut everyone up—but there were plenty of tracks that didn't get enough love in 2013. Here are 50 of them.


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Yesterday I had something of a Charlie Brown moment. In the brief space of time I was afforded to breathe during my daughter's nap, I allowed a slow moment for my emotions to catch up to my brain and become thoughts. They sounded something like this:
"It doesn't feel like Christmas. I was so looking forward to Christmastime, and now that it's here I just feel drained."
Every year, more and more, Christmas becomes a to-do list that I rush through in hopes of finishing early so I can put my feet up, bake some cookies (which I don't even eat any more, who am I kidding?), and somehow feel Christmasy. This is my first Christmas season with a child and I'm learning that the relentless nature of motherhood does not slow down or cease as holidays approach. There is no Christmas vacation for moms. If anything, I feel squeezed even harder as nap times and evenings are spent writing Christmas cards, wrapping gifts, and making sure every family member is accounted for. (Not that I don't delight in gift giving. There are a few gifts this year I'm counting down the days to give, I'm so excited about them.)
The highlight of my merriment comes when I turn on our Christmas tree lights and my increasingly vocal daughter Ooo's and Ah's and Wow's with wide eyed wonder at the glittering spectacle before her. This is her first Christmas and for her it has no meaning beyond visual sensory pleasure.
For me, this time means far more than cozying in to my hygge RV, looking even more Scandinavian these days now that the white paint is dry and the Christmas greens have been hung. Advent has always been a season of slow, steady contemplation, anticipation, of waiting for Christ.
Maybe this year more than most, the waiting means more. I'm weary this Advent season, just as the Jews were waiting for their Messiah when He graced them with his tiny presence two Millennia ago. Theirs was not a merry waiting, filled with eggnog, greenery, and lights. Theirs was a hungry waiting, oppressed and tired, but still a waiting filled with hope. Hope doesn't need to be filled with energy and smiles to stay in tact. Hope is determined choice. Its clothes are tattered and eyes have bags but its knuckles are white with determination.
I need that hope as the injustice of the world makes me feel drunk with anguish and the weariness of my life stretches me thin. This year I need to sink into Advent, even though I don't feel like it. My flesh feels like tuning out and binge watching cooking shows on Netflix while my daughter sleeps. My soul needs to breathe in the waiting hope of Advent. To sit in stillness, listening to the grace-filled whispers of the Holy Spirit reminding me that Christ is coming again and that coming is one of justice. I need to soak in the Scriptures that preach peace and joy and freedom to my soul. I need to gaze at a crèche and contemplate how incredibly inaccurate most of them are (let's be real: that hay would have been covered in blood and Mary would have been asleep when the shepherds arrived. I'd love to see a probably-way-closer-to-real-life manger scene). It's my first Christmas after having a baby and Mary's act of sacrifice and pain to bring us our Savior is now one that brings me to tears and slight cynicism at nearly every single Nativity scene.
If the only thing I get out of Christmas this year is a few minutes of communion with the Savior whom we celebrate and contemplation on His coming, then I can count it a success. In the immortal words of Linus, "That's what Christmas is all about, Charlie Brown."


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Corporate Governance
In fulfilling its obligations and responsibilities to its various stakeholders, the Board of ResApp Health Ltd is a strong advocate of corporate governance. The Board has adopted corporate governance policies and practices consistent with the ASX Corporate Governance Council's "Corporate Governance Principles and Recommendations 3rd edition" where considered appropriate for a company of the Company's size and nature.
Download Corporate Governance Statement
ResApp Health Limited
Level 12, 100 Creek St, Brisbane, QLD 4000
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ResAppDx-US is pending review of a request for De Novo classification and is not available for sale in the United States.
© 2020 ResApp Health Limited. All rights reserved. US Patent No. 10,098,569, Australian Patent No. 2013239327, Japanese Patent No. 6,435,257 and Patents Pending. ResApp Health®, the ResApp Health logo and ResAppDx® are registered trademarks of ResApp Health Limited in the United States and other countries.


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Android Tablets
Android Tablets: check out Android Store's carefully selected line of Android Tablets. These are the latest tablet computers and laptop PCs giving you awesome mobile computing convenience, ready to run and install PC Apps of your choice. All the products you see here should work in any country and are very easy for anyone to start using. There is also a range of Windows Tablet PCs aimed at the productivity users, keen to take advantage of the Microsoft tools on a large screen mobile device for work on the go. As a retailer, these tablet computers are a super hot category for you to profit from, either in wholesale bulk orders or single item dropship deliveries.
Android Store is an online retailer of Electronics, Phone accessories, Android phones, Android tablets, Android TV Box / Stick, Car accessories, Car DVD players, Car Video, Computer accessories, Electronics gadgets, Health and Lifestyle, 3D Printers, Home audio/video, IP cameras, LED lights, LED projectors, Mobile phones, Smartwatches, Sports and Outdoors, Sports action cameras, Surveillance and Security and everything else. Whether you're shopping for yourself, a school, a university, or a business. Computers and Electronics – Thousands of products to buy. Also offers free shipping, discounts on special occasions and gives out discount coupons. Has an easy user interface as well. Visit our online store at: www.androidstore.shop


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JS Home JS Basics Basic Maths Functions
Basic Maths Functions
In this lesson we look at some of the basic maths and assignment operators. Basic mathematical operations are supported in JavaScript using symbols as follows:
- Addition uses the + symbol as in 10 + 10
- Subtraction uses the - symbol as in 10 - 10
- Division uses the / symbol as in 10 / 10
- Multiplication uses the * symbol as in 10 * 10
- Modulus uses the % symbol as in 17 % 5
You can also assign numbers to variables and apply maths to them.
// Create some variables and add them together.
var firstNumber = 10;
var secondNumber = 10;
alert(firstNumber + secondNumber);
Operation Order.
There are certain rules to follow when performing several mathematical operations in the same statement.
- Use parentheses to group operations you want performed first.
- Orders (also known as indices and exponents) which are powers and square roots etc. are appplied next.
- Division and Multiplication take precedence over Addition and Subtraction.
- After these precedences are applied maths is worked out from left to right.
* No Parentheses so multiplication will be done first.
* Result is 32 not 50
alert(2 + 3 * 10) + ' NO Parentheses so multiplication will be done first';
// Parentheses will be done first.
alert((2 + 3) * 10) + ' Maths in Parentheses will be done first';
Maths Shortcut Assignments For Variables
There are several shortcuts available when performing maths on a variable.
- += will add the value on the right of the equal sign to the variable of the left.
- -= will subtract the value on the right of the equal sign from the variable on the left.
- *= will multiply the value on the right of the equal sign by the variable on the left.
- /= Divides the variable by value on the right of the equal sign.
- ++ Placed after a variable will add 1 to the variable.
- -- Placed after a variable will subtract 1 from the variable.
aTotal = 0;
aTotal = aTotal + 10;
aTotal += 10; // Same as above
aTotal = aTotal * 10;
aTotal *= 10; // Same as above
aTotal = 0;
aTotal++; // aTotal equals 1
Lesson 5 Complete
In this lesson we looked at some of the basic mathematical functions, precedence and assignment shortcuts.
All the arithmetic operators are discussed in JavaScript Reference - Arithmetic Operators and the assignment operators are discussed in JavaScript Reference - Assignment Operators. So any operators not covered here will be discussed in those references.
Related Tutorials
JavaScript Intermediate Tutorials - Lesson 6 - More Maths Functions
JavaScript Advanced Tutorials - Lesson 3 - Number
JavaScript Advanced Tutorials - Lesson 4 - Math
What's Next?
In the next lesson we look at variable usage in JavaScript.
JavaScript Reference -
Arithmetic operators
JavaScript Reference -
Assignment operators


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Modular Matrix w/Inbuilt Video Wall Processor
Smart-e are proud to announce the first in our new 'Jupiter' matrix range, the MDX-8x8+ 'Io'. The MDX-8x8+ 'Io' is a marked improvement over the original MDX-8x8, boasting improved control functionality through Web Browser support, Front Panel control and the 'mix and match' of matrix and Video Wall processing. By combining Seamless video switching with modular input and output modules Smart-e sets a new benchmark for complete integrated AV solutions, all of which can be controlled either via our new Front Panel display and internal web browser, or via the traditional IP and RS232 control systems.
4K KVM/CAT 6/Fibre Extender
More than 10 years ago Smart-e released the world's first multipurpose transmitter/receiver Cat 5 extender pair, the SLX-111. Known as the "Swiss Army Knife" of AV products on account of its multitude of features, it became a true classic of the analogue age.
We at Smart-e have built upon this legacy, and are proud to announce the 4K-5W155 'Deimos', our digital successor to the SLX-111.
Modular HDMI/HDBaseT Distribution Unit
Smart-e are delighted to introduce the first in Smart-e's new 'Neptune' range, the 4K 9:9 'Neso'. The Neso is a modular channel distribution unit, built with ease of installation and maintenance in mind.
Smart-e's many years of experience designing for and working alongside some of the best installers in the business has given us a unique perspective on the installation process, and we believe this new product is perfect for the installation and upkeep of medium to large scale AV projects.
Video Processing
Smart-e is proud to present the first product in our new 'Pluto' Video Processing range, the SDS-2500 'Hydra'.
Like its namesake, the Hydra is multi-faceted, able to act as a 2x2 video wall processor, a 4x4 seamless switching and scaling matrix and includes the ability to act as a quad-split PIP/POP processor with multiple user select layouts.
HDBaseT Matrix Switcher
With the introduction of the 4K-8x8-L, Smart-e reclaims its place as a provider of quality, all in one HDBaseT matrix solutions. The 4K-8x8-L is a multipoint to multipoint HDBaseT matrix switcher, supporting eight HDMI inputs with eight HDBaseT/HDMI mirrored outputs, in addition to eight audio inputs/outputs and ten infra-red inputs/outputs.


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Detyens Shipyards, Inc., located in Charleston, SC has supported commercial shipowners, domestic and abroad, with an experienced team that emphasizes quality, safety and competitive prices. Our facility, with 3 graving and 1 floating dock ranging from 122m x 24m up to 229m x 33.5m, deep water access and location, provide owners with the finest dry-docking experience in the United States East Coast. During our 55 years in the marine industry, Detyens has worked on a wide array of projects. From large commercial repair & conversion projects to simple routine dry-dockings, Detyens works to make sure that all of their customers leave the shipyard satisfied and on time. Come by our booth 219 to see how Detyens Shipyards can be of service to you and your vessel.
Dry Docking and Repair Services
Detyens Shipyards is a full service, one stop shop for ship repair located in Charleston, South Carolina.
Boat Building / Repair
Electrical Systems & Components
Propulsion / Power


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We are one the renowned manufacturers, exporters and suppliers of highly nutritious Yellow Turmeric Powder that comes in rich yellow color. This powder is processed by our professionals in utmost hygienic conditions using high tech technologies. The offered Yellow Turmeric Powder is known for high nutritional value, freshness, purity, safe packaging and longer shelf life. To ensure quality, this is stringently tested on various parameters. It is available in different packaging options as per the requirements of the clients.
Shalimar Chemical Works Private Ltd. All Rights Reserved.(Terms of Use)
Developed and Managed by Infocom Network Ltd.


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We ask that you choose your items carefully before placing your order – we will not offer exchanges or returns if you simply change your mind.
You may return your items provided the below are met
Original proof of purchase, a receipt, is supplied
Goods are in unworn/unused original condition with swing tags still attached
Goods are returned within 30 days of purchase.
We do not offer exchanges to change your size. Should you wish to change your size we will refund your order once your goods have been returned. Another order will need to be placed through the store
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text: Looking for a new home in a new city, perhaps away from the support of friends and family, can make even the most independent person nervous. If you are a person with a disability, this anxiety can be compounded by a list of factors. People who are disabled often have to consider not just public transportation, but the accessibility of facilities, service providers, career opportunities, and even more diverse or specially equipped entertainment options.Read More