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According to Wikipedia, an energy drink is a type of beverage containing stimulant drugs, chiefly caffeine, which is marketed as providing mental and physical stimulation. Key word: marketed. The energy drink industry markets or advertises their products to bring in the money, but do you really know what's inside those cans?
Energy drink sales are higher than ever and have been predicted to continue rising, making the market expand towards $21 billion in sales by 2017. Energy drink companies such as Red Bull, 5-Hour Energy and Monster are becoming billionaires because they know how to manipulate their easy targets, and that includes gaming communities. "Companies say these products are safe to market and sell to children as young as 12, but the evidence says otherwise," says Jennifer Harris, director of marketing initiatives at the Rudd Center for Food Policy and Obesity at the University of Connecticut.
New energy drinks are also on the rise, such as G-Fuel and GungHo, along with "deaths and hospitalizations due to overconsumption of caffeine and sugar-laden beverages." The energy drink industries are actually targeting the gaming communities with their new labels, such as Mountain Dew Game Fuel and Nintendo Power Up Energy Drink, but don't buy into their cheap tricks. Aside from their colorful, attractive, and gamer-oriented online advertisements, they are also trying to influence you through television. A study done in 2012 results that energy drink manufacturers advertise their products primarily on TV channels that has the most adolescents in their base audience.
Energy drinks can harm your body because of the dangerous amount of caffeine consumed. It may cause short-term effects, like anxiety, irritability, and withdrawal symptoms, or cause long-term effects like chronic heart conditions. It also affects with your sleeping patterns, which may affect your brain development in the long run. Understand that feeling tired and sleepy is your body's natural way of telling you that it needs to rest, and once you chug down an energy drink you are disrupting and masking that signal with the use of harmful chemicals. However, if you need that extra energy to game on for a little while longer there are plenty of natural, healthy, and harmless ways to get some quick energy, like as a handful of almonds!
Read on: Selling the Young on 'Gaming Fuel'
Written by: Amairani Aleman
Edited by: Alex Miller
Don't Just Be Fit. Be Gamer Fit.


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MaxEx, Inc is currently seeking to fill an entry level position within our organization. Candidates need to be ambitious, self-motivated, and responsible, as to assume a variety of duties. Candidate will need to possess at minimum the following: a good working knowledge of Microsoft Office; the ability to interface both directly as well as indirectly with customers and vendors, providing an above average level of customer service in all work environments; have the availability to travel as well as work nights and weekends when necessary and the ability to meet deadlines and follow up with time sensitive issues.
Duties to include yet not limited to:
Inventory control of client product and properties
Company as well as customer service ordering
Assist in client property preparation for venues
Onsite assistance with installation and dismantle
In house fabrication
Shipping and receiving
General office responsibilities (phone, maintenance, etc.)
Please submit resume and salary requirements to: email@example.com
We provide a complete turnkey solution!

subset: commoncrawl


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By: Eric Sommers
Welcome back to Little E's Commander Archive, home to all things related to Commander. As we move forward here on the Questionable Endeavor Network, we will branch out from time to other areas of Magic: the Gathering, from casual to competitive formats and events that impact the game as a whole. This brings us to our topic this, which has been all the buzz since it was announced.
Recently, Wizards announced the Masterpiece Series to much fanfare. Going forward there will be a collection of cards included in booster packs that will highlight a thematic element of the block by reprinting a variety of cards from throughout Magic's history. This series technically started in the original Zendikar block in the form of Priceless Treasures. In order to highlight the adventure and treasure hunting theme of the popular set, Wizards randomly placed Power Nine cards, dual lands, and an assortment of reserved list cards. These weren't reprints so much as old cards mixed in with the new. In order to capture this flavor and excitement, WIzards included the Expeditions in the Battle for Zendikar block.
This proved to be a huge success. In order to collect these full art lands that Magic players bought up boxes of booster packs in order to grab these fancy fetchlands, shock lands, and other famous cycles. It was a clever way to get players excited about the set. It was a chance for newer players to get their hands on hard to get or expensive cards. It gave collectors some cards to chase after.
All in all, the community was hyped about these Expeditions, and it led to an increase of sales. It also begged the question, why doesn't Wizards do this more often? Flash forward a year to the soon to be release Kaladesh and the inclusion of the Inventions and the announced Masterpiece series.
The Masterpiece Series looks to put those older cards in newer players' hands while keeping them out of standard. The cards selected for the series will be tied thematically to the block. So with Battle for Zendikar we got lands, Kaladesh gives us artifacts, and we anxiously await what the series holds for us.
So far, the cards selected for the series have been big successes. As said earlier, shock land, fetchlands, as well as filter lands from Oath of the Gatewatch were popular choices. Looking at Kaladesh, we will get Mana Crypt, Crucible of Worlds, as well as many famous artifacts. Both blocks seem to be delivering on their hype. It almost seems like each set has a built in From the Vault. So what do we have to look forward to with these awesome gifts from Wizards?
In order to figure out what to expect of the Masterpiece Series, we need to look at past blocks and see what options there could be for their own Expeditions. Each block has its own identity, so it should be easy to assign some Masterpiece level cards to them. Lands and artifacts seem like such obvious choices to start this series. Both are major facets of the game and make up some of the most valuable cards in the history of the game. The cards types also highlighted a major theme of the block. When look at other blocks in history, we can start to see what the Masterpiece Series has in store.
Looking back into the not so distant past, we will find the Tarkir block. Now, the block kicked off with Khans of Tarkir, which introduced us to the wedge tribes, so it would be hard to shine the spotlight here. But Fate Reforged and Dragons of Tarkir were heavy with Dragons. It seems like a Masterpiece collection of dragons would be perfect for this block. Dragon is one of if not the most popular creature type and there are plenty of choice dragons that could be highlighted.
However, can Dragons hold their own against the value of cards featured as Expeditions? I didn't believe so at first, but was proven wrong when I checked out this article. It seems the right choice of dragons with the correct art could see some value as high as the Expeditions. With dragons being such a popular creature type, it is only a matter of time before we get them in the form of masterpieces.
Theros block was twofold in its theme. First, it was a Greek inspired block, and secondly it was an attempt at an enchantment block. It might be hard to do a Masterpiece series on Greek inspired cards, but enchantments is something that everyone can get behind. The card type has always been popular and the history of Magic gives us many fine selections to choose from. A search of expensive enchantment proves that there is plenty of value in this card type. We will likely get a return to Theros as some point, and Masterpiece enchantment series is inevitable.
Our next block is Return to Ravnica, and this is where things start to get a little murky with our selections. Ravnica is defined by its guilds and is highlighted by multi colored cards. I suppose the theme of the Masterpieces could be organizations in Magic's history, but the more obvious choice here is gold cards. Although there is quite the selection of cards that can be highlighted for the series, the value of these cards pale in comparison to those previously listed. Wizards would really have to find some hidden gems and spruce them up with some new artwork to get players excited for this series as they would be about Inventions.
All in all, I am excited about the Masterpiece Series. It will create a great deal of speculation for each new set. It was a great addition in order to get reprints into the hands of new players without disrupting competitive formats, gets collectors excited about buying new sets, and will spice up some limited games (since the cards are legal if opened during booster drafts and sealed events). Sure, not all series will be considered equal, but I am confident that Wizards will use the Masterpiece Series to make as many players happy as possible with their selections in the years to come.
Let me know what cards you would like to see as Inventions in Aether Revolt or what kind of themes you would want to see on other planes or in past sets. Thanks for joining us on the Questionable Endeavor Network for Little E's Commander Archive. Keep coming back each week for more Magic: the Gathering content. Happy Commandering!
By: Eric Sommers
Welcome to Little E's Commander Archive, the "semi"-weekly article where we discuss our favorite Magic: the Gathering format. This week's topic extends beyond the realm of Commander and looks at a tradition of Magic that goes back to the very first printing: cycles.
A cycle is a group of cards that are related in flavor or abilities. It can be a vertical cycle; one that appears at common, uncommon, and rare or mythic. More commonly we see horizontal cycles that appear across all five of the colors.
Cycles are used quite often by designers to highlight themes and to generate buzz about certain cards. Many players get excited about these cycles, and they tend to be popular cards. Some cards don't start as cycles, but because of popularity, R&D will create the cards needed to make a full cycle in later sets. Sometimes we have to wait quite some time for these cycles to be completed, or in the case of our focus today, still waiting…
Commander players love cycles. Quite often we will make room for complete cycles to be in our decks if our color identity allows it. But what happens when we get to those incomplete cycles? It is not much fun to see other colors get fun cards that are a part of a cycle that doesn't represent the one we are playing.
Often times in earlier designs, certain color combinations weren't represented in cycles. When this happens, we Commander players are left waiting for day the cycle is completed so we can quickly add them to our decks
So which cycles are Commander players the most anxious to see completed? Here are my picks for the cards we are impatiently waiting for.
The Morphing Cycle
Morphling sure didn't start as a cycle. Printed in 1998, the art was originally commissioned for a reprint of Clone. It was only later in development that R&D felt that Clone was too confusing for players. They opted to instead create the card that would be known as Superman. Morphling can do it all and for sometime was considered the most powerful creature in Magic.
In 2007, Magic released the set Planar Chaos, which warped the color wheel. There were several cards in the set that were meant to be variations of popular cards in different colors. Most players enjoyed the call back to the original blue shapeshifter.
It wasn't until 2009 when Conflux brought us Thornling that the cycle conversation began. My original thought was that we would see the white or black variation every other year. Well, we have yet to see a Grave-ling or an Angel-ling (I like one of those more than the other). We did get something close back in Dissension, but that even predated our red counterpart. Players have been waiting for the other variations of this shapeshifter for last seven years. It is only a matter of time before this cycle is completed.
The Missing Leyline
Back during the Ravnica block, we got a cycle of nearly free enchantments. Although they ended up fairly popular, Leyline of the Void proved particularly valuable on the tournament scene. It was used widely in the Modern format since it was a powerful sideboard card against Dredge and other top decks at the time.
In order to make the card more accessible to players entering the format, Wizards decided to reprint the card in M11. Instead of reprinting the whole cycle, however, we were given a whole new batch of leylines for the other colors. So now while red players can enjoy two leylines, there's a void for the black players who missed out on the second wave. It would be unlikely that we will see another leyline printed though outside a supplemental.
Gold Clones
I spoke briefly about Clone earlier. After R&D figured out the rules baggage, it was a constant reprint thereafter, along with a large number of variants. It took quite some time (from 1993 to 2011), but those variants started crossing into multi-colored territory. These gold clones have been quite popular amongst the Commander crowd.
Though I don't think this was originally meant to be a cycle, the fact that we have three of the five allied color pairs has a lot of players buzzing for the other two. Blue-white seems to be the one getting the most demand, but I feel like a red-white clone will be a great addition to the cycle.
This is a series of cards that is likely to be completed, but it will take quite some time. Once we have these two clones, the crowd will change it's tune and start looking for the enemy colored clones. Sit back, we will get them in time.
The Missing X Guild Spell
Return to Ravnica was a block that put a lot of pressure on Wizards to produce. The original trip to the plane was one of, if not the most, popular blocks in the game's history. The sequel brought a lot of new legends and reinforced some of the most popular commanders and deck builds. Cycles were used to help flesh out each of the guilds with each getting guild leaders and charms.
Overall, the block was a success. One shortfall though was the missing X spell for the Selesnya guild. Each of the other nine guilds were given a X spell except our token making brethren. When the community questioned the decision to leave green and white out in this cycle, Mark Rosewater claimed that it was not done intentionally. The fact that each of the other guilds had an X spell was merely coincidental.
Of all the cycles I list in this article, this is the one I believe to most likely be completed. It will likely be in a supplemental set in order to preserve the flavor of Ravnica.
Magus of the Spells
The Time Spiral block was pure nostalgia overload. Each set focused on either the past, alternate reality, or future of some of Magic's favorite characters and cards. It was in this block that we were given the super-cycle of cards known as the Magus Cycle. Each set had its own cycle of creatures who had the abilities of a famous card that was previously a different card type; Time Spiral had artifacts, Planar Chaos lands, and Future Sight enchantments. It seemed like the perfect cycle was complete.
However, Commander 2015 gave us the new Magus of the Wheel and changed everything. We now had a Magus that represented a famous spell from Magic's history. It made a great deal of sense and was exciting to see. Most players got excited about the other four cards that would fill the cycle. It was an obvious conclusion since there were five decks in the series and there would be room for one in each. However, we were left scratching our heads and given just the one new Magus. This is another cycle I feel will be completed over time, perhaps one in each of the yearly Commander sets. Still, it would have been nice to just give them all to us at once.
As you can see, unfinished cycles are as big of a part of Magic's history as any other element of the game. Players look for these cycles to be completed rather sooner than later. Which cycle did I miss? Which cycle would you like to see completed for you Commander decks? Come back and check out our future articles about the Commander format here on the Questionable Endeavour network. Happy Commandering.
By: Eric Sommers
Welcome to the first ever installment of the newest addition to the Questionable Endeavor, Little E's Commander Archive. I am Little E, and I will be your host every week as we look at various deck ideas, share some stories and experiences, and do our best to keep up with current events, mostly within the realm of the Commander format for Magic the Gathering.
It is an exciting time for Commander players. This Summer's releases and the recent announcements from Wizards about upcoming products has given the Commander community a lot to look forward to. Upon the release of each of these products, I will review them within the context of my favorite format. So without further ado, I give you…
Back in 2014, Wizards released Conspiracy, the first ever Magic: the Gathering set designed for multiplayer drafting. No one knew what to expect from such a design, but the set was an overwhelming success. The set was full of gems for multiplayer formats making it incredibly popular among Commander players. Two years later we now have the second installment in the Conspiracy line. With it we have some new legendary creatures to choose as Commanders, some fun new planeswalkers, and an assortment of new mechanics to spice up our games.
Feel free to read the entire article, or if you'd like, follow the links below to jump to each section:
TV & Movies
Troy Boesen
Sal D
Henry Huge Pecs
Andrew Lister
Coard Lowery
Adam Salzer
Eric Sommers
Jason Stuart
Ray Williams III
Contribute your own writing today!
January 2019


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Terrain.org recently received:
Strategy for Sustainability: A Business Manifesto
by Adam Werbach
Harvard Business Press
by Adam Werbach
Harvard Business Press
From Harvard Business Press:
One June 1st, General Motors and Citibank were kicked off the Down Jones stock index. Just five years ago, we thought that these companies — and other institutions like Circuit City and Lehman Brothers — were the heart and soul of American capitalism. We were wrong. They were not sustainable.
It's time for a business strategy framework that matches the turbulence of the 21st Century. From Adam Werbach, one of the world's leading business advisors to companies such as Wal-Mart, NBC-Universal, and Frito-Lay and a recognized though leader on sustainability issues, the new book Strategy for Sustainability: A Business Manifesto outlines a plan for integrated and long-term business success.
"Companies are creating a strategy for sustainability becuse they know the world will change, and they need to build an organization that's nimble, flexible, and connected in order to succeed," says Werbach. "Any company that hasn't rethought its business plan in the last year is operating on an outdated playbook."
According to Werbach, sustainability has four key components: social, economic, environmental, and cultural. Companies that successfully engage all four components improve their bottom line and simultaneously drive new business opportunities.
Werbach calls on business to move past the old Jim Collins' BHAG (Big Harry Audacious Goal) mentality and instead adopt "North Star Goals" — aspirational business goals that aim to solve a global human challenge as well. North Star goals, already adopted by the likes of Dell and Starbucks, not only help businesses stay profitable but they help companies engage their employees to navigate the turbulent waters ahead.
Learn more at http://www.strategyforsustainability.com/.
Terrain.org will not be reviewing this book in a future issue.


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Overdriven Reloaded is a game that took me back to the days of top down space shooters of old and upon starting the game I instantly went back in time. With only my Atari ST and Pro 5000 joystick missing, instead replaced with an a Xbox One X and Xbox Elite controller, I had flashbacks of the insanely busy levels and varied difficulty that these type of games had back in the early nineties and the rage I used to feel while trying to defeat the same boss for the 27th time. Overdriven has the charm of a retro shoot 'em up with a modern sharpness to it, but be warned, it's a very busy game and when I say busy, I mean there is so much going on on screen at once that it might just make your eyes hurt.
With its very retro look and feel, Overdriven does a good job of capturing the essence that made games like this one of the most played genres of the late 80's to early 90's and with its simplistic approach to its controls it certainly comes close to looking and feeling like a top down shooter of old. Consisting of up, down, left, right, fire, special, shield and mines, there isn't much to master in terms of its controls but rather how you deal with what is going on on screen determines how well you will do overall. As mentioned earlier, the on screen action gets very busy, so busy in fact that it's almost impossible to see any of the level design due to the amount of enemies, neon missiles, lasers and bombs flying around the screen at any one time.
The hectic action going on throughout feels very distracting and you won't have any clue as to what's happening, almost firing blind in to space, hoping that you shoot something of importance. It doesn't ease up either as the further in to the levels you go the more manic things get. While the overall gameplay is responsive and simple to master, it's somewhat overshadowed by the overly busy goings on within the levels. I felt as if luck was what I was relying on rather than actually mastering the game which lead to some regular occurring frustrating moments. The difficulty of this game is so up and down and lacks the consistency needed to enjoy the overall experience and the fiddly frustrating boss fights don't help things either. The key to the success of these shoot 'em up games way back when was the progressive difficulty levels that needed mastering, but unfortunately here, Overdriven suffers with a lack of continuity.
While it plays fairly well overall, it is sadly let down by its dull level design and overly hectic action happening on screen all at once. There is very little story to follow and the audio, while it's not particularly bad, is however somewhat underwhelming at best. Visually, Overdriven looks sharp and vibrant, with the multicoloured neon bombs, lasers and missiles all popping out of the screen. It is an accurate representation of the top down shooter games of old and the overall look has been faithfully recreated. The issues with the visuals though come with some concerns and what this visual style and manic on screen action can also bring is some potential issues to anyone sensitive to bright flashing images and lighting effects on screen. There is so much going on that it may be somewhat of an unenjoyable experience for anybody with sensitive eyes or somebody who is unable to look at constant flashing images for a prolonged amount of time.
There are various modes and difficulty levels to choose and as this game was originally a PC release, Overdriven Reloaded on Xbox One comes packed with all the additional DLC added after the base release on PC, so everything is included for one fairly small price point. There is certainly enough to keep players busy here and at just short of £7 on the Xbox Store, it offers pretty good value for your money. I will say though that Overdriven Reloaded in its current form is a very niche game and will only appeal to fanatics of this genre and who love a challenge that tests their patience and durability of their controllers. While it ticks all the boxes of a nostalgic trip, it unfortunately falls short with too many little issues getting in the way of what could of been a more enjoyable experience than it ended up being.


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San Diego is one of the major cities in California. Also, it is the eight-largest city in the US. This place is famous for its mild-year round climate, extensive beaches, and natural deep water harbor. As there are not much fluctuations in the climate, the garage door owners in this place do not encounter much glitches on account of climatic conditions. This doesn't mean that they do not come across any problem in their garage doors. Technical issues are something that is unavoidable in a garage door. With so many garage door repair service providers in Alpine California, it becomes difficult for people to choose the best one. At San Diego Garage Door Experts, Alpine California, you be rest assured that you get quality garage door repair services in Alpine California.
San Diego Garage Door Experts has both experience as well as offers superb work. Our reputation is built on our dedication towards our customer service and our passion for resolving the issue as soon as possible. We hope that you will take some time to browse our site out in order to discover what sets us apart from other service providers. Meanwhile read below to know about our various garage door repair services in Alpine California:
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Brand Introduction
The EC SENSE R & D center is located in Munich, Germany. The core team members are all senior experts which have had the research and development
experience of electrochemical gas sensors for several decades. The core R & D targets are gas sensors, oxygen sensors, flammable gas sensors, and VOC sensors.
The EC SENSE team has successfully developed a new "polymer electrochemical gas sensor" based on the principle of electrochemistry for many years. The technology is currently the leading technology in the world. Our products have been improved in both technical performance and production technology, and
the product has many characteristic, like good stability, high resolution, high precision, the whole range of pure linear, long lifespan, low temperature, ultra
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integration of R & D, production, packaging and testing. The product conformance reached over 95%, and the product pass rate reached over 99.9%.
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intelligence, practicality, high quality, low cost, and provide high quality, low cost and easy to use for global intelligent environmental protection, industrial
safety, life health safety monitoring emergency rescue monitoring and toxic gas monitoring. Intelligent gas sensor products


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Department of Imperial Embrace
A new way to look at American Empire, from a Czech friend of mine (extracted from a longer text and only slightly edited):
I have less and less problems with the fact that we all live in an era of American empire. After all, who could be sure that a different world empire (let's say, Chinese) would be much better. I think it is wise to accept the empire as a reality. Yet where I see the real problem is rather in the fact that despite being the most powerful empire in human history, America behaves not as an empire but as a nation-state. This is the frustrating thing. American majority opinion continues to live in a denial of the fact that America is an empire and, as such, the country should behave accordingly. As much as the Brits once did when voting their government in the time of British Empire, Americans, too, should learn to take into account what impact their vote will have upon *both* domestic and international reality. This is difficult, but if the Brits managed (as Henry Kissinger pointed out in the Washington Times some two years ago), why can't the Americans? One has to have the hope that this will happen one day. (So far, no sign of it.)
Thus we need more American imperialism (this is no joke, Alex), i.e., more conscious awareness in American minds of the fact that, yes, the U.S. is an empire, and therefore its voters should behave accordingly. (However, they cannot do that unless the media teach them so. And it seems to me that the New York Times, at least, has been recently going in that positive direction; not always, yet there are some signs of change; of awareness that this kind of self-contained American politics hurts both the world and America.)
So far, despite the omnipresent boasting of the "America-is-the-best-country-in-the-world" type, most regular Americans still live in denial of the fact that "empire -- that's us."
I do not love any imperialism but, realistically speaking, there will always be some kind of hegemony structure of the world. It's better to accept it than to fight it; what makes me worried, though, is that most Americans have not yet fully accepted the fact.
Yes, there is some wisdom to the proud-to-be-the-empire movement that started in D.C. some time after 9/11. It is a very conservative wisdom, yet I start to believe it may be the only way in which to make Americans more realistic and, by the same token, less dangerous for the world and for themselves. Americans need to turn into adult, i.e. responsible, imperialists.
I believe it is more realistic to expect that Americans (despite their own past as a British colony) may warmly embrace their imperialism -- more realistic than to expect they may reduce their proud patriotism. The heated patriotism is responsible for the lack of realism in the exercise of American global dominance (see, for instance, the way of fighting the recent enemies). Despite many examples to the contrary, America has been -- at times -- quite wise when dealing with domestic issues. Yet its way of dealing with international issues since the time of Germany's reunification (perhaps the last major international event in which the U.S. acted wisely, i.e., both in its own and the world's interrests, by supporting it and pushing it forward even against Gorbachev's and Mitterrand's mild opposition to the idea uf united Germany) is increasingly, and after 9/11 painfully, awkward and often even based on a lack of understanding the world.
So, long live American imperialism -- if and only if it is consciously and responsibly embraced by its very agent: the American political elite AND the American people.


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Podcast: Play in new window | Download
Michelle Wolf roasts politicians at the White House Correspondence Dinner, then gets roasted. NY's Attorney General tries to evade double jeopardy laws in order to hold Trump's team accountable. And, we break down the IDC: Independent Democratic Coalition. How are they ruining NY State politics for us all?


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We Need To Look At the Big Picture When It Comes to Environmental Reviews
Changes to a bedrock conservation law threaten to put blinders on federal decision-makers.
Changes to a bedrock conservation law threaten to put blinders on federal decision-makers.
A look back at why EPA's rollback doesn't hold water.
Watch the video and sign up to stay informed on issues that affect outdoor recreation in the Colorado River Basin.
Western states take another important step toward stabilizing the Colorado River.
A brief history of the Clean Water Act and how an EPA rule could strip many streams and wetlands of its protection.
There's tremendous demand for landscape-scale water conservation projects that involve farmers, ranchers, urban communities, and sportsmen—now, the program that makes these projects possible could see a boost in the 2018 Farm Bill.
Restoration work on waterfront habitat did almost as much to revive the community as it did to improve conditions for fishing.
It may be "America's hardest working river," but the drought-hammered Colorado River can't support current demand from cities, farms, and fisheries without collaborative conservation.
The precipitous drop in hunter participation should be a call to action for all sportsmen and women, because it will have a significant ripple effect on key conservation funding models.Learn More


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How To Be Happy person and happy life 40 Different Ways
How To Be Happy person and happy life 40 Different Ways
There are a lot of ways to find how to be happy 40 different ways in your daily life ? in this tips i am trying to highlight some solutions which you can follow to make yourself happy. Well this is easy to become happy and to find happiness. If you facing trouble life then read below happy ways and how you can be a happy person again. This article is helpful for those people too who want to be happy all the time in their life. You will find that how you can become happier and positive person that everyone loves you.
Well this is the simple thing but unfortunately we have never focused on our lives and we never understand the strategy of life we never understand the rules of life. Happiness is an art of life, but this is the myth that "when anyone laugh too much he or she have to cry the most afterwards" and because of this thing people have fear and this is why they don't share their happiness and they even don't live happily.
how to be happy Many people have fear that if they will share their happiness with anyone their happiness will be afflicted by the evil eye and this is why they don't share their happiness it's because our mind have accepted the negativity. Everyone is frightened inside. Everyone doubt on the people who do anything right for them. This is the fear that is built inside ourselves and just because of this fear we don't believe on anyone. Just try to find happiness everywhere by excluding negativity from your mind.
Face Expression – for how to be happy
1st tip how to be happy Your face is an open book and your face expressions can show that what's going on your mind. Face have 125 muscles excluding tongue, it doesn't matter that you have to express anything from your tongue. You can express your feelings by your face. So try to make happy face or smiley face. It will be helpful for you. So try to keep yourself happy by making smiley faces.
Happy on your fate – for how to be happy
2nd tip how to be happy The most important thing is to be happy on your fate. Some people aren't happy on their fate and they blame their fate for everything so first of all stop blaming your fate. And some people start comparing their fate with others fate, this is why people don't get happy so don't try to compare your fate with anyone else just try to be happy in every situation. These situations can be in any form even if you are poor or rich you need to find happiness in your life, your happiness doesn't depend on the money.
Feeling of gratitude – for how to be happy
3rd tip how to be happyYou should have feeling of gratitude and this means that you should try to be thankful for everything. Just make yourself happy in every single situation. Many people we met say that they have this issue or problem with their life this is why they are not thankful for what they are and for what they have. When you have feeling of gratitude automatically you accept your fate and you find yourself the happiest person.
Relations – for how to be happy
The most important thing that will help you to be happy is to value and respect your relations either it is of blood of friendship just try to value them. Try to make you relatives happy for the sake of your own happiness. You will surely find happiness when you will indulge yourself in the blood relations. You should try finding ways to make your relationship strong by doing something for them.
Happy marital life
5th tip how to be happy For your own happiness you should have happy marital life and you can have happy marital life when you respect your wife or husband and when you will value each other. This is so important for every person to have a good relation with wife or husband. Try to express your love for your wife or husband. By saying few words of love you can give happiness to your partner and this will be helpful for the fruitful relationship.
When you love to gather information and you love to search and seek information then automatically you will find happiness because when you try to seek knowledge you come close towards the nature and your love for nature become more and more so try to learn as much as you can. Learning is very important thing for happiness.
7th tip how to be happy The most important thing that will make you happy is in forgiving people. When you forgive someone it means that you have a great heart that is full of love. You should know that by forgiving someone you will come closer to your Lord. He will be happy that you have done something good for His creature. Forgiveness is something that Lord likes the most. So by forgiving someone you will also feel happy.
8th tip how to be happy Travelling is something that will help you to get yourself attached with the nature and will make you happy. When you have love for nature then you will travel and you will want to find the beauty around. This will give you motivation and this is best way to make yourself happy and to get indulge in the natural happiness. Travelling is so important for everyone if you really want to make yourself happy.
Believe in Lord
You should have believe in your Lord that whatever the situation is He will never leave you alone in any situation as He is your best companion of life so trust Him and you should have fate in Him. Don't say it by your tongue that yes you believe in God try to practically believe Him. Your life will become easier then.
Don't hurt anyone
10 tip how to be happy Just try to make everyone happy and this doesn't mean that you need money to make anyone happy. No, you should have positive feelings for everyone. Don't make fun of people and don't hurt anyone because when you will hurt someone internally you won't feel good too and you will not be happy so don't hurt anyone just because you are hurt.
Unconditional love
When you give someone love or when you do something good for others so don't except anything from them because this is will not worthy for your own self. You won't feel good when you start excepting from people. Just try to give unconditional love and do it for your own self then you will be happy. Do it for your own happiness for your own sake.
Set an intention
Everyone have some intentions in their lives and they follow their dreams by working day and night for it but have you ever heard or ever did that anyone have the intention to make themselves happier person or love themselves? Well you should have this aim in your life that you will enjoy your life no matter what ever the situation you are facing or whatever you are going through.
Find reasons to be happy
You can find happiness by doing something good for people around you. By sharing love you can have the happiness and by helping someone by not accepting it from them can make you feel happy. So try to love everyone and help everyone even they are strangers or your relatives. Once you will do something good for people you will find freshness and happiness in your heart and soul.
Exercise more
Lots of studies showed that doing exercises or involvement in games can change your mood and can make you feel good. No matter how much you have worries or how much you have tensions when you do exercise your mood will change automatically. Try to do work out and make yourself easy and relax.
15th tip how to be happy You should have positive thinking because positive thinking will let you love people and bring happiness for them. So try to think positive as much as you can and try to exclude negativity from your mind because negativity is the main root of sadness. When you see the faults in someone's life you automatically start hating them and that's why your perception for the world remains the same that everyone is mean.
Try to make yourself perfect
Don't compare yourself with other people because when you compare yourself with someone than automatically you will be degrading yourself and this will make you sadder. This is why you need to think that you can do better than anyone and you have the same ability as other have. You only need to search good things inside yourself.
Don't let things just to pass on easily from your life, try to practice mindfulness and it means that you need to concentrate and pay full attention towards the current moment and try to accept it in a non-decisions movement. Don't judge anyone. And don't label someone that they are bad or they have something that you hate the most try to find positive thing in the people.
Sleep well
tip how to be happy You should need to get the healthy sleep for the sake of reducing negativity from your life because when you sleep well then your mind will be able to get fresh vibes from everyone and you will try to accept the people's behaviour with everyone. Mostly students have this issue that they don't sleep well because of the pressure they have from their family and studies too. So they lead towards depression.
Help others
You need to take out of some time for the people to whom you can help and this will be very helpful for your own happiness. Because by helping others you will be able to make yourself mentally happier. When you dedicate some time and money for the needy people this will affect on your own happiness.
Live your own life
20th tip how to be happy You should live your own life by focusing on the thing that you will not get life again and again once you are dead everything will be finished. So try to focus on the happiness of your life. But not hurting anyone other for your happiness.
Reduce complications
Life is so simple and it have no rules but you have make your life complicated by so many thoughts so just try to be positive and don't think so much. Over thinking can give your life a stressful phase so try to live a healthy life without having depression and without making your life much complex.
Balancing is best
You should know that how you can balance your life. If you are facing problems then don't let them involve that much in your life that you won't be able to get out of it. Try to be happy with your problems because once you will able to learn to overcome the problems by living happy you can become the happiest person.
Make new friends
You should make new friends and try to share your feelings with them try to share your happiness and give them all of your love and attention you will then find that people who are near to you will help you in having happiness try to make those people your friends with whom you feel yourself comfortable and you think that they are exactly of the same nature like yours. So make new friends and add them to your happiness.
sharing doesn't means that you have to share your money or your wealth it means that you should share your love with people with your friends and family so that you can proof yourself relaxed and tension free. By doing something good for the people who are in your surroundings will help you to get inner peace.
Don't put yourself in race
It means that you don't have to think about people around you is having a great job but you don't have a good job so you start working hard and start giving tensions to yourself and your family to achieve the same thing as you have seen in other person. Don't put yourself in the race otherwise you won't be able to get the happiness in your life.
Extra activities
Try to take out some time from your busy schedule and try to involve yourself in the extra activities so that you will be able to relax your mind and soul. This is so compulsory for all of us to make ourselves mentally relax. So involve yourself in the activities like outing, watching different programs, reading or writing and many more.
Make your hobbies
If you are interested in doing something like if you are interested in reading books so make it your hobby so that when you have a free time you can read books like novels magazines extra. So make some hobbies to make yourself calm and peaceful. This is indeed necessary for everyone to indulge themselves in hobbies.
Watch tv shows
You can also watch some tv shows you can watch some dramas or if you don'twant to be depressed than you may watch some funny movies or shows. All you need to relax your mind and not to think on the unnecessary things so for that purpose you can go for watching TV and this is the best idea to make yourself happy.
Share your feelings
It become more difficult when you start ignoring your feelings by thinking that what will others think about you or what other people will say about you. So don't hesitate while sharing your feelings or thoughts. Mostly people think that now they are grown up so they don't express their feelings like if they want to cry or sometimes they want to behave like a child they don't do so because they have fear of the society. Don't hesitate don't shy don't think and don't fear about what people will say just share your feelings.
Spend time
Sometimes people are so busy in following their dreams that they don't even bother that they have a family with whom they can spend their time so for those people just to get out of the world of race and to get out of the tensions you really have to spend some time with people around you like spend time with your family and old people of your home. When you will listen to them you will find happiness inside yourself.
Don't live alone. Be in gathering, try to involve yourself in gatherings because when you are alone you are surrounded by different negative thoughts that harms you alot. So try to indulge yourself in your family. Visit to relatives and friends. Share your thoughts with them you will going to feel much better by doing this thing.
You shouldn't think so much or worry about your future that what will happen next. How, when, why, where are the questions that are the main root of sadness. You should believe on God and you should thanks him for everything just try to think good so that you will have good. Don't over think it will make you mentally ill and physical ill too.
Don't degrade
When you start comparing yourself or your children with others children or with other people, you then degrade yourself and this is why you can't even get out of negativity around you. Don't compare your childres don't compare yourself. Nature has given a power to everyone so you just need to utilize that power in a good manner without degrading yourself or your children.
Don't doubt
Don't doubt on anyone even they are from your family or friends or anyone don't doubt on them because doubting is one of the great negative factor inside a human that ruin him badly. When you doubt someone you are full of negativity and that's why you become mentally unstable because of keep on doubting people.
Set your achievements
When you are free from everything like you don't have something to do so start setting a goal or ambition in your life that you have to do this thing and you have to work hard for this thing because when you set a goal automatically you start utilizing your thoughts and power in fulfilling your goals of life.
Reading books is a very good hobby or activity for everyone. When you read books you comes close towards the people. You came to know about the world around you. That world is full of mystery and when you start reading books magazines or any encyclopedia book your mind is then able to solve those mysteries. So read as many books as you can.
Don't give up
Sometimes in fact mostly people don't get what they dream for and sometimes when they are working hard they don't achieve those things that they wanted to achieve so in that case they give up. They shouldn't give up they should keep on trying and make it their own destination or fate. So stop giving your dreams up and work more hard to achieve what you want to achieve.
Healyour traumas
Sometimes people don't heal their past traumas and they start living their lives under that traumas. And this lead them towards depression and that is why they are unable to live an happy life. So you shouldn't make your self a depressing person to gain sympathy. Just make yourself an happy person by getting out of the traumas.
It means that when you start excepting yourself the way you are then you will be able to get happier life. Don't compare your personality your body your face or your achievements with anyone else. Just try to accept yourself the way you are the way you live the way you look.
Have deep meaningful conversations
Talk to your friends discuss about the issues or discuss about the things that are going on these days. By debating and by talking about meaning-ful things you can share your thoughts and feelings. That will be helpful for you because things you will share with your friends and family will relax your mind and will make you able to have patience and acceptance.


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Jewellery Bags & Accessories Prints Tea Towels and Pillow Cases
Clothing Flat Pets Books Fridge Magnets
Heavy Petting Zoo Book
A digitally printed and hand made book featuring illustrations of some of the happier and heftier pets commonly found in petting zoos.
8 pages, (7 illustrations). 160 mm x 140 mm (closed). 1255 mm long unfolded
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Tool- and clamping technology
We are partners of the machine tool industry. Together with an experienced team we deliver support and advice all about tool technology. Do you have any questions? Then just give us a call and you will learn more about our mechanical program for machinery.
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Whirling tools from GLOOR
GLOOR whirl heads are used for your machine resp. Whirl unit designed. The heads are equipped with 3, 4 or 5 circular blades.


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If you follow this blog and you've followed our renovation journey, you probably noticed that we took a little break from projects. My husband and I needed a breather to get refocused and ready for some spring projects coming our way. Well, to get our feet wet once again, we took on a small but impactful project in our master bedroom.
Have you ever seen something that took your breathe away and you knew that you HAD to have it in your own home?? Well, meet this dreamy wallpaper from Photowall that has completed our bedroom! Photowall has just launched a unique wallpaper collection with Swedish artist and fashion designer Martin Bergström. The wallpaper collection, Flora Hysterica, consists of five patterns that Martin made out of dried 19th century flowers. I chose one that has deep green tones, which I always find myself attracted to.
I like keeping my home looking clean and minimal, but I also love adding contrast and drama. When I first saw this wallpaper, I could immediately imagine it behind our bed, acting as a large piece of art, or an extension of our headboard. The mural reminds me of something that you would see while visiting an art gallery in Paris or Milan. It's simply beautiful!
It was a super easy process hanging the wallpaper. Photowall included a glue packet, which intimidated me at first, but then proved to be easier than even adhesive wallpaper. Not even joking. All in all it took us 3 hours from start to finish. Which, for something with this much impact, that's nothing!
I mean, look at those colors!! You can pair so many color options with this design. As well as the other four designs that Martin Bergström designed.
Below is a beautiful video that illustrates Martin's inspiration for this collection.
Shop this wallpaper at Photowall.
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The 27th annual Suncoast Jazz Classic was held over the weekend of November 17-19, 2017 in sunny Clearwater Beach along the Gulf Coast of southern Florida. The festival featured 18 bands and personalities, playing all genres of jazz including traditional, swing, big band, zydeco, and Latin. A high school jazz ensemble inspired the audience with their young talents, and informal jam sessions entertained late night listeners and allowed amateur instrumentalists the chance the play with the pros.
First a disclaimer: I love the beach, so any concert venue located right on the ocean's edge instantly appeals to me. The Sheraton Sand Key Resort, key venue for the Suncoast Jazz Classic, boasts 10 acres of private shoreline, and I enjoyed taking a break from the music one afternoon to walk along the beach and even take go swimming in the ocean.
This was my second year at this jazz festival, which is held the weekend before Thanksgiving (see my review of the 2016 festival here). The concerts were held in various rooms in the Sheraton and nearby Marriott hotels as well as a few other locations around Clearwater Beach. Often there were bands playing in the bar areas which also serve food.
A few of the great bands which played during this weekend included (in alphabetical order):
Al Downing All Stars with Synia Carroll. From St. Petersburg, FL, this group carries on the jazz tradition of the late Tampa Bay musician Al Downing. www.aldowningjazz.com
Allred-Vache Florida All Stars. Co-leader and trombone player Bill Allred celebrated his 81th birthday on Sunday during the festival and proved what I've often thought, that playing music keeps one young. http://billallred.com/
Cornet Chop Suey. Hailing from St. Louis, MO this group presented a special set about Louis Armstrong. http://cornetchopsuey.com/
This video features the group's trombone player, Brett Stamps:
Dave Bennett Quartet. From Michigan, Dave Bennett on clarinet/vocals/piano and his musicians perform Benny Goodman standards mixed with lively Jerry Lee Lewis Rockabilly tunes and modern ballads. http://davebennett.com/
Here the quartet performs an original composition, "Heavy Heart":
High Sierra Jazz Band. From California, this group has been around for 40 years with various musicians and plays traditional jazz. http://www.highsierrajazzband.com/index.html
Professor Cunningham and His Old School. This group from New York City made its initial appearance at the Suncoast fest to great audience approval. They play originals and jazz standards. https://adriancunningham.com/professor-cunningham-and-his-old-school
Here the septet performs a class rock 'n' roll number:
Tom Rigney & Flambeau. Also from California, this group features Tom Rigney on violin/vocals, and plays a mixture of zydeco, boogie woogie, originals, and waltzes. http://tomrigney.com/home/flambeau/
Wally's Warehouse Waifs. From Michigan and other parts of the Midwest, this group plays Big Band and Swing favorites. http://wallysjazz.com/
My Takeaway…
This festival offers a great opportunity to hear a variety of music styles performed by world-class musicians in an informal setting. The Sheraton Sand Key Resort is an easy-to-navigate hotel with spacious rooms and several eating venues. If you want to explore the city of Clearwater Beach, there is a free trolley service that stops at the Sheraton, Marriott, and other city locations. The sunny and warm weather during November is a definite plus in my book. Finally, the volunteers who make this festival possible (along with the business and individual sponsors) are friendly and have the running of the festival operations down to a science. If you're considering dipping your toe into the jazz festival circuit, this is a great place to start!


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The Tromsø Arctic-Alpine Botanical Garden is home to thousands of plants and species from all parts of the world. Here you'll find tough little plants from the polar regions or the high mountains, which have difficulties surviving in the milder climates where most botanical gardens are located. We will take the whole family on a guided tour through the Botanical Garden, while keeping the kids interest with small assignments and quiz games through the walk.
We will also take you all to the Science Centre, which is located right above the Botanical Garden. It offers plenty of educational fun and close to a hundred interactive exhibits within the following topics: The sky above, Climate and weather, Energy and environment and Body and brain. A visit to the Science Centre is definitely for the curious-minds of all ages.
At the Science Center you also find Norway's largest all-dome full digital planetarium. Under the 360° planetarium dome, breathtaking shows come alive. The topics of the shows vary from the origin of life, stars and the universe, to our living climate and spectacular rides through the cells of the human body.
Practical information
All year
Departure time not set.
2.5 hours
Contact us for prices.
Activity level
People with disabilities need to notify is if special transport needs is required. Such requirements will be subject to the availability of suitable transport.
On request.
No meal.
Dress for changeable weather. Wear comfortable shoes.


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Measuring what we do
Our twenty-one mobile offices have empowered 173,193 people across South Africa.
Among others, some of the services offered by the mobile offices currently include unemployment registration, liquor license applications, business registration in informal economies, housing applications, land claims, builders registration and consumer protection.
We aim to empower the most vulnerable individuals who often lack funds to reach offices in economic hubs and ensure that they are not left behind. Our systemic approach promotes continual innovation and improvement to reach more people more effectively every year.
In line with our goal of inclusive development for all, we aim to reach 2.8 million South Africans over the next five years. Thanks to our on-board software, our service delivery is completely measurable and transparent and offers real-time updates, which allow us to obtain data at ground level. At any given time, investors can login to monitor project progress and the reach of their services – ensuring the success of projects co-created with MPS.


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ah, hope
A couple of weeks ago I returned to acupuncture. My fourth acupuncturist in as many years. To be fair, I like the first one, but she's moved so far north in my city, I can't get there. The two in between weren't right for me. They maintain that all I need(ed) is/was acupuncture – forget that Western crap. But I knew there was no acupuncture needle that was going to open my cervix.
I have mixed feelings about this. I'm very weary of people telling me what's wrong with me.
Yes, I've noticed that I can't get pregnant. Yes, I've tried ____.
She requested that I use OPKs this cycle. You know, to make sure we're trying when we should be.
I know I ovulate. I know my body really well at this point. Trust me.
So I had my surge. We timed it well.
And that opens the door to my faithful friend, HOPE.
So because a stick tells me timed it right, and I've been faithfully taking my bizarre (but well researched) passel of vitamins each day, and because I'm subjecting myself to another barrage of needles, I'll spend the next 10 or 12 days thinking maybe.
Without the stick and the needles, I don't expect anything. And I don't really expect anything different this time, either. Then again, I sort of do.
8 Responses to "ah, hope"
I've never gone back on birth control since having O. And I'll tell you something. EVERY cycle, there's a moment where I think "I'm pregnant." It's so stupid, because our chances are SO low. But there IS a chance.
So I know the feeling.
Hope can be such a persistent thing, but that is the point, right? Hoping right along with you that that "crazier thing that has happened" lands squarely on your doorstep.
hoping right along with you.
I think Acupuncture can work miracles. I am so happy to hear you are actively trying! I will keep the Hope family in my prayers…
Hope right along with you!
You know, hope creeping in like that makes me grumpy. I've been dragging my *** to my RE for blood draws and U/S to do a FET, and at times I forget that the thaw will probably just fail, again. That's when hope sneaks in, and in a way it makes the disappointment that much greater.
So yes, encouraging hope, thanks a lot acupuncturist.
I know exactly what you are talking about, we decided to give up on fertility medication because we each month there was that expectation that I would be pregnant and the disappointment was too much for me. I'm praying for you.
Yes, hope…
I think it is wonderful you have so much of it. I know can be both the fuel for your fire and what burns you. And I'm throwing another log onto the flames. As for hoping, I'm in, too.


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I don't do 'normal'.I've found that the more I write, the more I like being different to other authors. I write in first person, and I love to challenge a reader.I take the normal and switch it around.For me, I really enjoy getting a reaction from a reader. So if I can evoke an emotion (regardless of if it's the emotion the reader wants) then I figure that I've done my job as an author I want to be.I really quite revel in taking people out of their comfort zones and pushing them to read something different.My genre of writing is, well quite frankly, where ever my mind goes. I won't label myself because I don't like sticking to one genre.My goal with writing is just to take people away from whatever is going on in their lives, even if it's only for a split second.I'm a go with the flow sort of person and don't really take a course of action to get where I am going. I live in the moment and don't usually worry about tomorrow because whatever life is due to bring me, I'll be happy to accept.I love my family and friends and will help anyway I can if someone needs it. I really don't like people that are nasty just because they can be, I don't believe that's necessary, I mean life's hard enough as it is!I hope you enjoy my books, I've had a hoot writing them. There's more to come.....Til next time.M xx
Facebook | Twitter: @MargaretMAuthor
RELEASE DATE: September 3rd
Jaeger Dalton wants the land that was promised to him.Phoenix Ward isn't about to let anyone take Freedom Run away from her.He'll protect what's his.She'll protect what's hers.Jaeger is an arrogant ass, but he wants nothing more than Phoenix.Phoenix is stubborn and headstrong, and she wants Jaeger out of her life.Her father lost the family farm to gambling debts, but Jaeger isn't the only one who has a claim to the property.Sometimes it's best to let things go.But sometimes it's better to fight until the very end.
Raw, bloody, and uncensored, Grit is everything I expect from Margaret McHeyzer. There are just a few authors I know of that can spin a tale of the lives of motorcycle club members and still have them remain human, charming, and people to root for despite their uncontainable violence and unconventional lifestyle. In short, she's got a gift.
When the book opened, I had a bit of trouble guessing which main character was in the scene. It was only after I'd gone a few more pages when I realized that it was Jaeger's character speaking and I was totally appalled at what kind of life he had been forced to live.
Pheonix was a surprise, although I did guess that was her in the fight scene. How they got together, however, was something I didn't expect. Gotta love a woman who knows her way around a shotgun, I tell you. Her pigheadedness gets her into trouble but she can own up to her mistakes and tries to make up for them.
The only thing they both can't understand is why they're attracted to each other. While Nix is convinced her brain is malfunctioning, J is well on the way to calling his feelings an addiction. Can't help but adore this couple.
Although J is much wanting in the gentleman area, there is no doubt that what he feels for Nix is real and he'd risk everything for her. This to me is what makes a relationship work; he didn't even need to prove it to show her what he feels and it shines through. That she'd do the same for him speaks volumes as well.
With its alternating POVs, there was no problem finding out what was in Jaeger's and Pheonix's heads. I especially loved being able to root around in Jaeger's brain. This is truly a man who grew up in the streets, with no luxury of manners, concern for feelings, or filters. He speaks both his minds, both the main one and the appendage's. There were times I thought he loved his second head more than his primary one!
Grit, as Margaret McHeyzer wrote it, is a story that shows there's more to life than what you're initially given. Sometimes you just have to make your own way and find it out.
Sarge walks into the kitchen and looks between the coffee all over the fridge door, the smashed porcelain on the ground and me, chuckling.
"That went well," he says and lets his own laughter rip from his lips. "Heard her shrieking like a banshee out in the yard."
"She wants to go home." I rub my hands over my eyes and try to relax, but knowing she's pissed isn't great for me."
"Women are different," Sarge says with a shrug.
"Tell me about it."
"Sometimes it's best to shut the fuck up and not fight 'em." Sarge sits in the chair that Nix was sitting in.
"You pussy-whipped?" I ask as I feel my eyebrows draw together in question.
"Hmmm." He reverts back to normal Sarge. "Women wanna be told what to do, but you need to make it look like it's their idea."
"That's fucked. She should just do what I say and be happy with it."
Sarge shakes his head. "She's right, you're a dick."


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This can often be viewed as a daunting task for most woman, or something that is time consuming and achievable only with the skills of professional make up artists, therefore we have eliminated the confusion that presents itself with 'large pro palettes' and have created a product which is easy to use, travel friendly and most importantly effective for the everyday woman.
Our launch palette works over a wide range of skin tones, up to a mac shade NC45.
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Khaled A Hassan
Author of
MA 11 - Emerging Diagnostic/Biomarkers in NSCLC (ID 668)
- Event: WCLC 2017
- Type: Mini Oral
- Track: Advanced NSCLC
- Presentations: 1
- Moderators:M.I. Abdul Wahid, Martin Reck
- Coordinates: 10/17/2017, 11:00 - 12:30, Room 313 + 314
MA 11.10 - EGFR TKI Treatment Induces Active Deamination of 5-Methylcytosine and Leads to Acquired T790M Resistant Mutation (ID 9056)
11:00 - 12:30 | Presenting Author(s): Khaled A Hassan
- Abstract
- Presentation
- Slides
Epidermal growth factor receptor (EGFR) activation mutations occur in 10-50% of lung adenocarcinoma patients of Caucasian ethnicity and in 50% of Asian descent. Currently, EGFR tyrosine kinase inhibitors (TKIs) are first line therapy for stage IV non-small cell lung cancer (NSCLC) patients with EGFR mutations. Despite initial significant response to TKIs, most tumors develop resistance. The main mechanism of resistance detected in 50-60% of cases is a cytosine to thymine (C>T) single nucleotide transition mutation at position 2369. This leads to a threonine to methionine amino acid change at position 790 (i.e. T790M). Interestingly, a similar mechanism of C>T mutation is seen in imatinib treated CML and GIST tumors. Our data suggests that the C>T mutation is an acquired event secondary to 5-methylcytosine deamination with Activation Induced Cytosine Deamination enzyme (AICDA).
PC9 is a lung adenocarcinoma cell line known to have an EGFR del19 activation mutation and can acquire T790M mutation from T790M-negative clone. We utilized droplet digital PCR (ddPCR) to detect T790M mutations. In addition, qPCR was used to assess the expression of AICDA and NFκB pathway before and after TKI exposure.
Sub clones of PC9 cell line with no evidence of T790M mutation by ddPCR at baseline, were treated with EGFR TKI. After serially increasing the treatment dose, T790M mutation was detected by ddPCR associated with a significant increase in AICDA expression. Furthermore, using a UDG assay, we show that AICDA recognizes a CAC motif and can deaminate cytosine at position 2369. By mass spectrometry we established that 2369 cytosine is methylated. Deamination of 5-methylcytosine leads to thymine directly rather than uracil, explaining the C>T mutation. In addition, using ChIP assay and pharmacological inhibition we confirmed that NFκB binds AICDA promoter and induces its expression. Similarly, using a mouse xenograft model, EGFR TKI increases the expression of NFκB and AICDA; this is abrogated by concurrent use of an IKKα inhibitor. Knocking down AICDA by shRNA, decreases the rate of T790M development in PC9 cell lines after TKI exposure. Assessing AICDA expression in patients at baseline (n=4) and upon T790M mutation progression (n=4), there was a significant 20-fold increase in its expression.
Our data suggest that upon exposure to EGFR TKI, AICDA is overexpressed through an NFκB dependent pathway, causing the deamination of 5-methylcytosine to thymine, manifesting as T790M mutation and leading to TKI resistance. This indicates that T790M is acquired and its development could be targeted.
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The idea for this post actually started in my bedroom. We have a sign made from vinyl a friend gave us years ago and I've since remade for several wedding gifts. It says on it, "All Because Two People Fell in Love." So I started to think about my bulging calendar of weddings coming up in August and thought I would go on the hunt for cute ideas using vinyl for weddings. I decided to limit to 5 though to keep the post short…there are some many more ideas out there.
Mr. & Mrs. Bedroom Vinyl
I instantly fell in love with his ideas for over the bed. It might only be fun for about the first year while you're still getting use to it, but that's the great part about vinyl…it comes off and you can replace it without another new quote or piece of art that inspires you.
Available through Play on Walls Etsy Shop
Monogram Cake Plate Wedding Gift
I created one of these for a quick and simple wedding gift recently. Sadly I did not take any photos of the finished project. So I went in search of one that inspired me. I simply added the Bride & Grooms Monogram to a cake plate/cover that I picked up at Dollar Tree. I kept mine all white and added white tulle to the handle. Then I filled the inside with a cake mix, frosting, darling cupcake liners, sprinkles and a gift card for dinner (before or after they eat the cupcakes is up to them).
Create by Jessica Rocks and posted to Cricut Message Board
Personalized Wedding Party Cups
Stay hydrated on that special day with these darling personalized cups. Create one for the bride and her brides maids. Not only useful but also a fun keepsakes after that special day.
Purchase these through LylaBugDesign Etsy Shop
Reception Decor or Dance Floor Vinyl
Loved this idea!! I would love to see it applied at an actual wedding, wouldn't you. Added to the doors of a reception center would be such a great way to personalize a typically very impersonal space. And an even better idea…the reception dance floor, love it.
Available through Open Heart Creations Etsy Shop
Just Married Car Vinyl
Now I think applying vinyl to the window of a car is just sweet and something they could leave on there for more then one night. I think personalizing it would be darling too…even adding a stick bride and groom to the window would be super cute too!!


text: While working at Society, the (then) social media agency within King James Advertising, I had the pleasure of working on the always quirky Steri Stumpie brand. These illustrations were created for a competition where participants could win R10 000 every week, by describing what they would do with their Fun Fund. The looney-er the ideas the better. We created a few crazy inventions and illustrated them to advertise the competition and get the imaginations going.


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Adaptation mainstreaming and M&E training courses
Read more
Garama 3C is offering short training courses on adaptation mainstreaming and M&E. The next set of courses will run from 19-23 June 2017 in Norwich, UK.
Routes to resilience: Lessons from monitoring BRACED
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This paper shares insights, reflections and lessons learned from designing, implementing and reporting against the BRACED Monitoring and Evaluation framework.


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It is true that for "dig a well in the desert with a needle…" must be "very weird" and I do not think it could have any similarity with being "arénophile", passionate about the sands of the world. All this is humorous and has amused me. The first sentence of this report writing OGOULBIBI AMANNIYAZOVA Marias in the online journal RUSSIAN OBSERVER of 15 December instant, obviously calls to read the rest of the article.
This report has been made in Cavalaire during my show last summer and so my thanks go to the author of course I also for Ms. Elena Iakounine Editor and Mr. Mikhail Iakounine publishing director for' have published what is sure to interest our readers.
A link will give you access to the end of the article in the online journal. A translation is possible by clicking on the French flag at the top right.
In the world of sand
15 December 2013
"Dig a well in the desert with a needle" - this expression does not go out of my head, while I was talking to Bernard Remo (Bernard Remaud), sand collector. Collecting stamps, Cards, kalendariki, Bells, Cameras - all this is now clear. But collecting sand? What a whim? Who can that come to mind?
It turns, there are people, and their passion called arénophilie. To tell the truth, this arenofilov around the world is not so much. Bernard Remo with his collection of several thousand types of sand from around the world proved, it insanely interesting occupation. Recently in Cavalaire-sur-Mer (Cavalaire-sur-Mer, Var) ended with an exhibition of his collection. For three months, that lasted exposure arenofila from Hyères (Hyères), it caused great interest and became a sensation for many. I was lucky, I went to the library Cavalera, where the collection was exhibited, on the day, when Bernard Remo was present and answered questions from visitors.
In the spacious hall were everywhere glass cabinets, stands with transparent tanks of various shapes: tube, cup, vessels were filled with sand of different colors and configurations. It was still possible to admire the magnificent desert landscapes photos, beaches. There were also various objects out of the sand, shells, sandy rose, volcanic stones. You could even see through the big magnifier on the sand and scanty foraminifera, so called protozoa, living on the seabed. The most amazing thing - it photographs of different sands, increased if a giant magnifying glass. Thanks so convinced snapshots, as a handful of sand is different from all other. Grains of sand under a microscope look incredibly picturesque, sometimes, I would even say, appetizing.
Waiting, that all visitors have departed from Bernard Remo, I began to ask him your questions:
- Tell, please, how it all began? What sense is there for you, your collection?
- Began, like everyone else - traveling in the Algerian desert, wanted to take a souvenir, took with him a handful of sand. Of the next trip again brings sand. Then, watching him closely, see, how handsome he, thin, elegant, sometimes sensual. And then you start to collect because of its beauty. It so happened, that each of my trip, and I loved to go on holiday in deserts by jeep, began to bring the sand, puts it in a bottle, to label with the name of the place, date. Gradually simple admiration turned into a passion. Here you see 3 700 types of sand, and at home I have twice. And when I retired years 10 back, I had time to really do a collection, issue, stands and do the most important thing to photograph. That, shortly before retirement one of my friends told me about the association arenofilov. Through this association, AFA, I was able to collect almost sands from around the world. I liked the basic principle of association - the sand can not be sold, only exchange. When collecting stamps, Cameras or champagne corks, they have rates, and the sand belongs to all. Collection helps me to travel around the world, of course, only in dreams, Sands eyeing from different countries. When I get someone from the sand, I know, whence, of what exactly the place he came - from the sea or the beach from the ocean floor, from the river bank or from the desert. With the help of the internet I'm looking for this point in the world, and with the help of Google Earth, you can even see this place exactly. More, when you collect, you meet with people, who are interested in the same, and that you. For example, I met a man from Germany, Now we've been friends for several years, and he gave me his entire collection of sand, because it is no longer able to do this. Its sand is also exhibited here.
- The exhibition - it's all your pictures - very beautiful scenery, But the most striking photos grains, increased a hundred times. How do you manage?
- Photographer I'm doing for a long time. Collection I had to build special equipment, look here. - Bernard leads me to a picture with his fancy "multi-storey" device. - This is my own invention of the old apparatus for printing. Digital camera mounted on top, and under it a concertina magnifying lenses, below is the original "lift" with a transparent platform, where the object is: sand or foraminefery, I advance carefully selected under the microscope and washed. When shooting even need to breathe quietly, not to sdunut grains. Understand, such an increase is impossible to obtain clarity evenly everywhere. I make up one shot, then lift the five-hundredths of a millimeter area with sand, rented more, move the pad again and again rented. So, I make 25-30 shots of sand or foraminifera, then a special computer program selects all clear parts and gives one shot. Per photo takes me 3 o'clock…
- And how is your wife reacted at the beginning for your gathering?
- Do you know, this collection is cheaper, than to keep a horse or a mistress, Bernard laughs.
- Yet, first you did not know, This will result in what is your passion. Every time you bring home sand, have a seat, clutter up, so to speak, rooms…
- As, I'm retired, do not go to work, home all day. What to do? Care for the garden, the house? And then what? It is better to sit in the lab, engaged in business, than going to the bar, playing cards, drink beer. I must say, I was lucky - I live in the village, in a large farmhouse. We had a garage, now our machines are "asleep" in the yard under the open sky, and in the garage I arranged laboratory, built shelves, stands for a collection, I can show my guests Sands.
- I've been in the desert, on the beaches. I always thought, the sand is everywhere uniform and monotonous. Examining your sands in tubes, in jars, in pictures, impression, the sand in each place unique…
Bernard leaps and silently leads me to one stand:
- Here are three types of sand from the beach in the cavalry Bonporto, they were taken at a distance 30 meters apart. Look, how they are different.
— Why?
- Each species was brought over different. In the desert the same - one dune sand brought from the north wind for, and on the nearby sand Barkhan formed through air masses on the other hand, Sands and turned out different. Various forms of, measurements, Colour…
Bernard excitedly tells and shows me a stand with dozens of species of sand from Algeria, lists intricate geographical names, passes to the stand with the volcanic sands of Libya…
- Honestly, I first heard the word "foraminifera", — I translate my interlocutor to another topic, - As you explained here, You can only get them from the bottom of the sea, they do not exist in the rivers, nor in the ocean, nor in the desert. When you dive and get them, they are still alive?
- No, they are inanimate. Science knows 50 thousands of species of these mikrozhivotnyh, 10 There are thousands and to this day. Foraminifera are known for a very long time, they were known by the ancient Greeks, Plato, Strabo mentioned them in his writings. Science of them began to develop the most with the 1920s in connection with the search for oil. Them determined specific geological layer. For example, when laying the tunnel under the English Channel, with all modern technology corridor builders determined necessary under the layer, where lie foraminifera, a layer of blue limestone…
- On the show I saw one stand, where there is one test tube with sand from Russia, Kazakhstan, Armenia, Turkmenistan…
- Yes, it stand with sand from around the world, I received from each country. Later, I received and other sands of these countries, but these - the first. This stand is represented by approximately 160 countries, whereas in the world 172 country. But, honest, of your countries have very little sand. I have no ties to your country, difficult to establish contact; I, unfortunately, do not speak in English. But, if you know the sand collectors, I'm happy to get acquainted with them, I have a lot of sand on the exchange…
Then his eyes lit Bernard Remo special shine, like all collectors of the world, when it touches an object of their passion. And I say goodbye to him.
Ogulbibi Mary
" The' RUSSIAN OBSERVER " online :


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Crystals can be used as tools to help heal, focus, transmute and channel energy. Each crystal has its own vibration and when used with intention can assist in personal development. Crystal Clearing Spray is included for cleansing the stones before working with them.
The Kit ContainsBloodstone – helps with decision making Carnelian – encourages determination Garnet – helps with dream manifestation Red Jasper – grounds and stabilizes energy Tiger's Eye – brings luck to new endeavorsCrystal Clearing Spray – to cleanse the stones
Additional details— Handmade in our Brooklyn, NY shop / studio— Makes a great gift!


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Improving Efficiency = Higher Quality Audit
Challenge: Denise C. Dampier CPA, PLLC needed audit software that would provide a higher quality audit and ensure that all risks were addressed and help the firm reduce time spent on audits.
Solution: Since switching to Wolters Kluwer's Integrated Audit Approach, the firm has saved an average of 25 percent in time on every audit, improved accuracy and a quality audit, and increased profit margins by 10 to 12 percent.
Focused on Quality and Efficiency
Denise C. Dampier CPA, PLLC is a certified public accountant practice based in Charlotte, North Carolina. The small firm assists businesses and individuals with tax preparation, planning, bookkeeping, audit and accounting. Working with non profits is one of the firm's specialties.
Denise Dampier, CPA, became an expert in non profit audit work because a friend starting a church needed financial statements to attain financing. The church's brokerage firm enjoyed working with her firm and referred other non profits.
"I'm so pleased with Wolters Kluwer for my non profit audit work and for my comp and review work. My first use of the solution was a small audit on a church, and I was able to set up the audit program specific to this client in less than an hour."
— Denise C. Dampier CPA, Owner, Denise C. Dampier CPA, PLLC
An #AuditorProud Moment
The Wolters Kluwer Integrated Audit Approach is an end-to-end audit methodology that produces higher quality audits. Additionally, this approach improves efficiency through dynamic, iterative processes, and tools that encourage auditor judgment and helps auditors make informed decisions.
Denise says, "Using [my previous vendor's software] drove me crazy because I had to go through a lot of unnecessary steps to make sure I wasn't missing anything. At this level, you're having system peer reviews, and if that's the one they pick to look at, you would be doomed. I love that Wolters Kluwer tailors questions in the software — and leaves an audit trail to help ensure that you don't miss anything."
The integration of the software makes switching back and forth between the programs a thing of the past, which significantly improves efficiency so that firms can do more with fewer resources. That's certainly the case with Denise Dampier CPAs.
Major Time Savings
Dampier reports a 15 to 25 percent time savings on average on every quality audit, and often even more time.
"On some items, it saves even more because everything in Knowledge Coach is easy to use and customize."
Dampier now does the same amount of work in less time, boosting her profit margins by 10 to 12 percent. Check out the video below and see for yourself how the future of auditing demands an evolution!
Better Customer Service
Taking less time per audit means that your firm can provide more thorough guidance to clients.
"I'm always trying to educate because that will make my work easier, too. Thanks to Wolters Kluwer's Integrated Audit Approach, I have more time and not feel so stressed out about a deadline. I like this software a lot. It's really easy to use."
It's important to become an expert in the industry in which you work and stay up on regulations and trends. Dampier has this advice specific to non profits.
"Remember that the client is running a non profit for reasons other than profit, and so they're different from a corporate situation that's about the business and profits. So, you have to have a different mindset. It can't just be about money. It has to be how this benefits the organization and the people the organization helps."
Now, Wolters Kluwer's Integrated Audit Approach has expanded to include TeamMate® Analytics, so that you can perform data analytics work that traditionally, is impossible. Additionally, CCH® Audit Accelerator has been added, so you can gain as much as 40-48 hours per engagement, depending on the size of the audit.
"Adding the CCH Audit Accelerator and TeamMate Analytics solutions to our audit workflow has changed our world, though. What use to take as much as 180 hours in years past now takes as little as 1-hour. That is an amazing amount of time saved. With it, our auditors can now deliver deeper insights to the client, thus enhancing the client's experience. We are looking forward to moving toward "continuous auditing" throughout the entire year."
— Muhammad Hussain, Senior Audit Manager, EOS Accountants LLP
See for yourself how you can create higher quality audits with a complimentary demo of all or any one of the Integrated Audit Approach solutions.


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Questions about your booking? Contact us
Property Facilities
Green Nature Resort has all the facilities you expect from holidays to Turkey. Highlights include: three swimming pools, sun terraces, sunbeds, parasols, four water slides, two children's pools, two restaurants, snack bar, four bars, and amphitheatre.
There's also: beach shuttle, children's club, fitness centre with indoor pool, laundry facilities, Wi-Fi connection in lobby, jewellery shop, and mini-market. The 24-hour reception offers luggage storage, doctor on request, babysitting service, and pool towels.
The Green Spa features: face and body treatments, Turkish bath with foam massages, and sauna. The animation programme includes: volleyball, darts, aerobics, step and water gymnastics, table tennis, tennis, basketball, football, billiards, and computer games. Water sports and PADI diving courses are on offer at the beach.
Room Facilities
This Marmaris hotel has 630 modern guest rooms, consisting of Club Standard, Resort Standard, Club Family, and Resort Family Rooms. Highlights include: bathroom with shower, minibar, air-conditioning, telephone, safe, hairdryer, satellite TV, and balcony with pool or forest view.


text: HomeNewsWatch This: GREFF Shares Music Video For Brand New Single, 'Rain' Rajrishi Murthi December 11, 2018 News, Video Ever since making his debut back in 2013, Nagpur-born producer Yugesh Madhwani has gone on to become a staple part of the Indian dance music scene in recent years. After garnering significant success with his previous alias The Unknown, 2018 witnessed the birth of his newest project, GREFF. Having shared the stage with some of dance music's biggest stars in recent years including Martin Garrix, Alan Walker, W&W, David Guetta amongst others, GREFF delivered his debut single, 'Rain' earlier this November which has now received a brand new music video. Right off the bat, the track begins on a pop-friendly note as a chilled out, tropical-influenced production work breaks into a vibrant, yet conveniently catchy drop. Led by Arizona-based singer/songwriter Nino Lucarelli's mellifluous vocals which turns out to be one of the track's bigger highlight, the newly released effort is also accompanied by equally fun visuals which manage to capture the original vibe of 'Rain'. Watch the music video for 'Rain' below.


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This fabric is from the Cherie Collection. 100% cotton. High density. Thin.
This fabric is sold in 1 yard , 1/2 yard. and fat 1/4 precuts and a 33" remnant from the bolt. please, choose below.
Machine washable.
Width: 43-44"
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Situated on 1/2 mile of Nueces & French Creek riverfront, wildlife includes axis, fallow, whitetail, hogs, turkey, dove & quail. 3 Edwards wells/game fencing. Lots of Indian mounds, elevation, and a great combo of game brush and senderos. Large barn & working pens, goat shed & chicken coop, and detached garage & workshop. An RV area includes 14 hookups and a clubhouse w/2 ba & kitchen. The 3 bdr, 2 ba, lodge style home has walk up access to the river. Vaulted ceilings, tongue in groove pine walls, and unique tile and hardwood patterned floor give the home an elegant hill country look, and there is a large loft on each side of the living room. An expansive porch affords great views and sounds of the flowing river. Farm implements are negotiable. Call today for an exclusive showing!
Click here for a printable flyer.