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Can anyone identify this uniform? It is a photo of my great grandfather that a relative came across. I know he was in the US Army during WW1. He moved to the US from Italy sometime before that. Nobody is really sure what he was wearing in this photo. Thanks for any information you can provide.
Seems as if the Copricapo head gear gives it away:
black capercaillie feathers flowing from their wide-brimmed black hats. These feathers are also worn on Bersaglieri combat helmets. They once served a military purpose, acting as camouflage and as a sunshade for the marksman's shooting eye.
But note that Italian Wikipedia firmly contradicts the species used for the feathers, as real capercaillie seem to have been too rare even when the regiments were founded. Instead the feathers seem to black Capon. The hat itself is called vaira in honour of Giuseppe Vayra.
Making that a Bersaglieri uniiform:
singular Bersagliere, (Italian pronunciation: [bersaʎˈʎɛːri]) (Marksmen in English) are a speciality of the infantry corps of the Italian Army.
Historical Geography. 1900. Italy. Besides the ordinary regiments of the Italian army there are several bodies of troops recruited for special purposes. Chief among these are the Bersaglieri, or riflemen, extremely mobile soldiers, with small, agile frames admirably adapted for skirmishing and scouting. A regiment of Bersaglieri, consisting of three battalions of infantry and one of cyclists, is usually attached to each army corps. (Photo by: SeM/Universal Images Group via Getty Images)
–– src: GettyImages: Historical Geography. 1900. Italy. Privates of the Bersaglieri, a crack light infantry regiment.


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Electrical Repairs in Baton Rouge
When you encounter any problems with your electrical, you need them to be solved quickly, thoroughly, and accurately. You rely on your home's electrical system every day, so you need it to always be as functional and reliable as possible. Problems with your electrical system can also be very dangerous, and having them repaired quickly is the only way to ensure that your home is safe.
At MK Electric Man, our professional Baton Rouge electricians will always be able to determine the precise cause of any problems your electric and find the best ways to repair them. Our professionals will always be able to provide you with prompt electrical repairs to help you keep your home's electrical system in excellent condition. Our repairs will be totally thorough, accurate, and safe, and we'll get the job done as quickly as possible.
Outlet Repairs
If your electrical outlets are malfunctioning or broken, it can be very inconvenient and frustrating, but more importantly, it can also mean that those outlets are very unsafe. If you have any problems with the electrical outlets in your Baton Rouge home, contact our professional Baton Rouge electricians as soon as possible to have them repaired. We'll be able to ensure that your electrical outlets are not only totally functional, but also completely safe.
Electrical Troubleshooting
Whether it's circuit breakers that trip or flickering lights, there are some electrical problems that every homeowner will most likely encounter. As common as these problems are, however, it can still be difficult to find their root cause. Our electricians will be able to troubleshoot your electrical system and find the precise roots of any problems you're experience, then we'll determine the best way to move forward with repairs.
Electrical Safety Inspections
If your Baton Rouge home's electrical system hasn't been services by a professional electrician recently, or if you are buying or selling a home, our professionals recommend that you have an electrical safety inspection performed. During an inspection, we'll look at every part of your electrical system, make sure all of your electrical wiring is up to code, and provide you with a detailed report of any problems that we find. We'll discuss any problems that we find with you in plain English, then we'll recommend the best ways to move forward with electrical repairs.
Keeping your electrical system well-maintained and in good condition isn't just the best way to keep your home functional, but it's also a very important part of keeping it safe. Our electricians will do whatever it takes to make sure that your electrical system is always kept in great shape.
Recent Electrical Articles
Why Electrical Repairs Should Never Be a DIY Project
Electrical repairs aren't just difficult—they're also very dangerous. Without professional experience, you run the risk of damaging your property, and you can also seriously injure yourself or someone else. On top of that, you may be legally required to have a permit before you perform any electrical repairs on Baton Rouge home.
Read More
Prevent Electrical Fires
Electricity is one of the most convenient parts of modern life, but because it's so integral to our everyday lives, it's easy to forget just how dangerous it can be. Electrical systems are a huge part of the comfort and functionality of our homes, but if they're not kept in the best condition possible, they can become major hazards. Keeping your Baton Rouge home's electrical system in great condition needs to be one any homeowner's biggest priorities. Making sure that your electrical system is in the best condition possible can go a long way towards preventing an electrical fire.
Read More

subset: commoncrawl


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Hayley MatthewsDatingAdvice.comApril 4, 2020 at 7:56 pm FORUM ANNOUNCEMENT
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sslk0928ParticipantJune 22, 2019 at 1:18 pm #202614
My boyfriend lives at home with his parents. He moved back there probably 3 years ago after college. We've been dating 9 months. I live alone in my own house. I don't have much money. So I don't have cable or internet. I have 3 dogs and a cat. My house is clean but it is run down and I do the best I can with what I have. It's still a home and better than living in the streets. I couldn't move home if I wanted to. There is no room for me at my moms. And I want to live on my own. I have for the last 5 years. I am 22 and he is 28. I have stayed one time with him at his parents place when they went on vacation. He has only been to my house maybe 3 times in the whole 9 months to watch a movie , I go to his parents house almost everyday. I feel like he doesn't want to come to my house because of my dogs and because it's not a nice house. And he won't move out and get his own place even though he has plenty of money. I feel like this is straining our relationship. I don't know what to do.
dashingscorpioParticipantJune 23, 2019 at 9:39 pm #202650
There ae only two ways to experience joy and peace of mind in relationships.
We either get what we want or we learn to be happy with what we have.
Accept them (as is) or move on. The choice is up to us!
Suffering is optional.
There is no amount of work or communication which can overcome being with someone who does not want what you want.
Clearly if he loves staying with his parents, dislikes dogs, and your house, then he's probably not "the one" for (you).
Thankfully we live on a planet with over 7 Billion other people!
"..he has plenty of money" – He should! He's working and living at home with his parents!
If you are unhappy in a relationship and choose to stay then you are choosing to be unhappy.
The world may not owe you anything but (you) owe yourself the world!
Life is too short to be trying to change water into wine.
Move on!
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Participants are encouraged to reflect on their experience through an artistic piece on "Walking a Mile in my Shoes" – reflecting on the lives of different people they encounter throughout the Mission Immersion process.
I'm not as poor as they think.
They look upon me with pity, and they think I struggle. My family may not have as many cows, our plot of land may be a couple acres less than others, but it's not as bad as they think. I have heard of worse.
Okay, so maybe I do struggle a little bit. Maybe I do when mother is unwell and my sisters need to be cared for. I'm not as mature as I look, and it's a tough job. Who cares for me? Maybe I do when I am only able to go as far as grade 10 with my education. Maybe I do when the eyes of the men at the river port shamelessly follow the 17-18-19 rhythm of my buttocks as I walk past with my family's laundry on my hips. They all notice it, I know they do. And it's not just the men either. It's the wives who consider me competition for the attention of their husbands. It's the young boys who are looking for some fun or for a little wife to prove their manliness. It is the little girls who wish to look like me when they grow up. They say it is in my African blood: the wide hips, large thighs, the booty, the "coca-cola shape", they call it. But that is where my connection with my ancestors end.
I'm nothing like them. My present situation is nothing like theirs. Abuela said many many years ago they got stranded here, brought in on slave ships from West Africa to work these lands, but they escaped their masters, settled near the Onzole and built a home and a community. Well, I say, lucky them! lucky us! We are this new breed of never before existed Afro-Ecuadorians. One of a kind. Our home is rich in fruit trees of oranges, sugarcane, guanabana. We thrive on our rice and plantains and shrimp. Dare I say, we live quite the life. These Africans, the people of my ancestors, now they, they struggle. I've heard stories of their suffering from the radio in Luciano's house. It's not pretty.
Yesterday, the gringos came back. The one who speaks our language said he would return with more of their kind to help build the school for my sisters. Or at least that is what I understood. Because then I saw her, among the gringos, but she was not their kind. She was more my kind. Skin dark like the cacao beans mother lays out in the sun to dry, large brown eyes, lashes to the heavens, not quite the coca-cola shape, but African descent nonetheless. She even seemed to share my struggle, for it appeared the young boys and the old men at the river port had eyes for her as well. She stood on the desk, silently covering up the thin planks of wood in fresh white paint. I stared. Que es tu nombre? De donde eres? She stared back at me for a couple of seconds. She had not understood. The one who speaks our language came to our rescue. Our precious Spanish-English translator.
As we spoke my eyes dug straight through hers, ready to uncover what secrets she hid. For she admitted that that continent was her home, and she had lived there all her life. Yet, her belly bulged not, neither were her eyes sunken with fear and destitute. It made no sense to me that dark-skinned one eats my plantain in her Africa and squeezes the juice from her oranges straight to her mouth like my people. She even knows that the burnt bottom of the rice pot is the best part of the meal. Yet her last couple of years were spent in school in Canada! How is this ever possibly so?
It seems we are more alike than I thought. If there is one thing I know now it is this: Our people are not all like her, able to travel the world. But they are not all like Luciano's radio says either, hiking deserts and unable to afford a square meal. They are no lower than me, and I no lower than them. We both experience a poverty that is no fault of ours, but a product of corrupt leadership, unjust hearts, blind eyes and apathy. But we fight, oh do we fight! We fight for lives better than our ancestors'. We fight to be heard and to be educated and successful. We fight out of love and a desire for justice for our people to encourage, impassion and motivate them. To remind them that They Too Matter.


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This concert has already taken place!
Elbphilharmonie Hamburg Kleiner Saal
Nico and the Navigators
Winter Journeys
€ 42.00 | 26.00 | 17.00 | 9.00
In a cross-disciplinary performance, singers, performers and musicians set off on a journey of discovery to explore Schubert's treasure-trove of songs in the here and now. They do so using not only their voices, but their entire repertoire of feelings and movements. In between the opposing poles of intimacy and escape, between past and present, they evolve new forms of interpretation and thus find their own very individual and modern approach to the music of the past.Show complete text
Julla von Landsberg soprano
Sarah Laulan contra-alto
Ted Schmitz tenor
Nikolay Borchev baritone
Apollon Musagète Quartett
Paweł Zalejski violin
Bartosz Zachłod violin
Piotr Szumieł viola
Piotr Skweres violoncello
Tobias Weber guitar, bass
Matan Porat piano
Michael Shapira choreography and dance
Anna-Luise Recke choreography and dance
Yui Kawaguchi choreography and dance
Bodo Gottschalk camera, live video editing
Oliver Proske backdrop, video
Sonja Winkler stage set assistant
Holger Müller stage set assistant
Cristina Lelli costume design
Miriam Lellek costume assistant
Fabian Bleisch lights
Andreas Fuchs lights
David Rusitschka Ton
Tobias Weber musical adaption and arrangements
Philine Tiezel Dramaturgie und Regieassistenz
artistic director Nicola Hümpel
»Silent Songs into the Wild«
Estimated end time
Supporting programme
Fri, 5 Jan 2018 19:00 / Winterreise – Vorstudie für ein nomadisches Leben / A Preliminary Study for a Nomadic Life, Kulturschloss Wandsbek
Blog & Streams
Promoter: HamburgMusik
A production by Nico and the Navigators and Bozar Music Brussels. A coproduction with Niedersächsische Musiktage and Konzerthaus Berlin. In cooperation with Elbphilharmonie Hamburg.
Funded by Kulturstiftung des Bundes, Freundeskreis Elbphilharmonie + Laeiszhalle e.V. and the Rusch Foundation.
During Your Visit
Enjoy the View
Between the old Kaispeicher and the new glass structure is the Plaza, a public viewing platform on the 8th floor of the Elbphilharmonie. Tickets for concerts in the Grand and Recital Halls include a visit to the Plaza two hours before the start of the concert or event; all other visitors require a Plaza ticket.More about the Plaza
A Diverse Cuisine
Food & Drink
A total of six bars in the Grand Hall and Recital Hall foyers offer concertgoers a varied cuisine before the start of events and in the intervals. Restaurants, cafés, delis and further bars await visitors in the »Störtebeker Elbphilharmonie« and in »The Westin Hamburg« Hotel.More about Food & Drink
Elbphilharmonie Hamburg
Kleiner Saal
The Recital Hall, designed in contrast to the Grand Hall in the classic »shoebox« style, offers seating for up to 550 people.
Finding Your Seat
All visitors enter the building via the main entrance. Admission takes place in the entrance foyer and is by concert ticket only. The »Tube«, an 82-metre-long, curved escalator, leads visitors up to the Plaza following admission
The Recital Hall is situated on the 10th floor and can be accessed via a stairway or lift. A cloakroom is located in the Recital Hall foyer.
Seat Preview
Are you curious to find out what kind of view of the stage different seats have? To help select your favourite seat, use your mouse to activate the representative seat views.
A cloakroom for guests of the Recital Halll can be located in the foyer of the Recital Hall on floor 10.
Baby carriages, wheeled walkers, walking-stick umbrellas, handbags larger than DIN A3 (42 cm x 30 cm) as well as sport bags, backpacks and suitcases must be checked in at the cloakroom. If required, wheeled walkers can be parked in the immediate vicinity of the hall entrances. Our front of house staff is happy to assist you in this regard.
Cloakroom fee: €1.50
Getting Here
Elbphilharmonie Hamburg
Platz der Deutschen Einheit
20457 Hamburg
The Elbphilharmonie can be easily reached by bus, underground, bicycle and ferry.
Underground line U3: Baumwall (approx. 450 m from the Elbphilharmonie)
Underground line U4: Überseequartier (approx. 950 m from the Elbphilharmonie)
Bus 111: Am Kaiserkai (Elbphilharmonie) (approx. 150 m from the Elbphilharmonie)
City bicycle (Stadtrad) stations: Am Baumwall and Am Kaiserkai / Großer Grasbrook
There are sufficient bicycle stands available in front of the Elbphilharmonie.
Ferry 72 (from Landungsbrücken pier): »Elbphilharmonie« pier
There is limited parking available in the Elbphilharmonie and the HafenCity.
Multistorey car park in the Elbphilharmonie (open 24/7, 435 parking spaces):
Please note that visitors to the Elbphilharmonie should use the entrance marked »Elbphilharmonie«. The entrance »Elbphilharmonie Hotel« is reserved for »The Westin Hamburg« hotel guests.
The car park operator APCOA offers a flat rate of €10.00 for four hours of parking. Every further hour or part thereof costs €5.00 as per the regular parking charge. The flat rate is only valid online and must be booked at least two hours in advance. Book the flat rate online at www.apcoa.de.
APCOA answers frequently asked questions about advance booking here.
Multistorey car park »Speicherstadt«: Am Sandtorkai 6, 20457 Hamburg (722 parking spaces, approx. 750 m from the Elbphilharmonie)
Überseequartier underground car park: Überseeallee 3, 20457 Hamburg (420 parking spaces, approx. 850 m from the Elbphilharmonie)
All halls and spaces are accessible for visitors with disabilities. More information at www.elbphilharmonie.de/en/accessibility.
Arrival Time
The Elbphilharmonie is a special building situated in a special place. Allow for plenty of time for getting to the Elbphilharmonie and the way to the concert area. We suggest first-time Elbphilharmonie visitors arrive at the main entrance 30 minutes before the start of the concert or event. Late seating is not guaranteed and latecomers may not be admitted to the concert hall.
Concert tickets for the Grand and Recital Halls authorise a visit to the Plaza from two hours before the start of the concert or event. Visitors to the Kaistudios require a separate Plaza ticket to visit the Plaza.
The foyers of the Grand and Recital Halls open their doors 90 minutes before the start of the concert or event. The bars in each foyer open simultaneously.
Admission into the halls begins 30 minutes before the start of the concert or event; for events offering pre-concert talks, admission into the halls begins 60 minutes before the start of the concert.
Smoking Ban
Smoking is prohibited throughout the entire premises of the Elbphilharmonie.
Photography and Video Recordings
Photography is permitted at the Elbphilharmonie for private purposes only. Please respect the privacy of other visitors and help ensure an undisturbed concert experience for all guests and artists. Employees and artists may not be photographed.
Photography, audio or video recordings of concerts and events are strictly prohibited.
Event-related video recordings or photographs for editorial or commercial purposes must be authorised by the Press Office of the Elbphilharmonie.


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I've recently completed (well, almost completed) work on my own kitchen. Working unpaid for four weeks is not something I'm keen to do again anytime soon but overall I'm pleased with the result. Due to budget constraints most of the carcases were bought premade and then fitted with grey Valchromat (a coloured MDF) doors and panels and Blum soft close drawers. The worktops and upstands are a mixture of ash and concrete. One day, when I've worked my way through the list of finishing off tasks, I'll take some proper photographs.
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All White are one of the few stockists of world renowned Cake Boss specialist cookware and bakeware. We stock a wide and comprehensive range of Cake Boss merchandise and If we don't have the product you are after we will do our utmost to source it for you.
Stockists of Cake Boss
27 August, 2014


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New Homes by Gentoo Homes
Gentoo Homes has over 15 years' experience and expertise in property related activity ranging from regeneration and modernisation to new build schemes. Since 2001 they have built more than 3,000 new homes and are now one of the North East's most successful housing developers.
They are a responsible builder who understands that property development isn't just about constructing homes with a great specification in a sought-after location, but, creating modern, sustainable homes their customers and future generations will be proud to call their own. As a part of the Gentoo Group, they're a profit for purpose business and reinvest back into Gentoo's Affordable Housing Programme.


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The basal joint is the joint which allows you to move your thumb into all kinds of positions so that you can pick things up, button clothing, open lids and do many such activities. When this joint at the base of your thumb develops arthritis, causing severe pain and hindering
functionality it is known as Basal Joint Arthritis (disease which attacks or destroys a joint). In terms of Head, Shoulder and Hand Division, MAX Saket & Gurgaon, former Dr Gupta, Director 'The Hand & Upper Extremity Surgery' at The Medanta Institute of Bone & Joint Disease, Gurgaon, "Basal joint arthritis is a degenerative disease that wears down the cartilage (protective covering that surrounds the ends of the bones and allows them to glide and move smoothly) surrounding the joint. Without the cartilage, the bone ends rub against each other causing damage to both bones and the joint.
The patient should immediately consult our medical team >> click here for appointment
Arthritis at the base of the thumb is one of the most common locations and thus can be very disabling and pain from this condition may impede the most basic everyday tasks. Thus it needs to be treated diligently and efficiently.
Dr Gupta with an experience of 20 years and over 18000 successful surgeries to his credit coherently emphasizes that women should be extremely careful regarding this arthritis. He stresses that though the cause of this form of arthritis is unknown in most cases but usually some past injury, fracture or severe sprain or joint laxity increases the chance of developing this form of arthritis. Though it can affect any age and gender, women above 40 are usually the targets of this disease.
The most common symptom of thumb basal joint arthritis is a deep, aching pain at the base of the thumb. It often worsens with activities that involve pinch, including opening jars, turning door knobs or keys and writing. As the disease progresses, patients experience pain at rest and at night and often start to lose their pinch and strength in their grip, stresses Dr Vikas, an eminent surgeon who has been the first to bring many international techniques of treating complex hand and upper extremity problems in India.
The patient should immediately consult our medical team >> click here for appointment
For relief, your surgeon initially may suggest anti-inflammatory medications, ice, heat, cortisone injections, thumb exercises, nutritional supplements and even splints to support thumb during activities.
But if you do not respond to non-surgical treatment then your advanced arthritis will have to be treated by surgical techniques which might include removal of arthritic bone and joint reconstruction, bone fusion or realignment techniques.
Surgeons adopt the mode of treatment that is best applicable to the patient after complete appraisal and as regards surgery, Dr. Gupta says, "A variety of surgical techniques are available that can successfully reduce or eliminate pain and improve thumb position and
function but the degree of function and strength that is restored varies."
FAQ – Basal Thumb Arthriti
- Frozen Shoulder
- Shoulder Dislocation / Shoulder Instability
- Rotator Cuff Tears / Injuries
- Scapula Fractures
- Shoulder Replacement
- Impingement Syndrome
- Proximal Humeral Fractures
- Clavicle Fractures
- Loose Body Removal
- Synovial Biopsy / Synovectomy
- Slap Injury and Repair
- AC Joint Injury
- PASTA Lesion and Repair
- Hand and Wrist Fractures
- Carpal Tunnel Syndrome
- Basal Joint Thumb Arthritis
- Distal Radius Fracture
- Scaphoid Fractures
- Radial Club Hand
- Rheumatoid Arthritis
- Metacarpal Fractures
- Giant Cell Tumors (GCT) Tendon Sheath
- Phalangeal Fractures
- Congenital Trigger Thumb
- Radial Nerve Injury
- Median Nerve Injury
- Extensor Tendon Injuries
- Flexor Tendon Injuries
- Ulnar Nerve Injuries
- Nerve Injuries Finger
- Mallet Finger
- Thumb Extensor Tendon (EPL) Rupture
- Dupuytren's Contracture /Disease
The thumb easily moves in all directions with the help of basal joint which lies at the base of the thumb. When the basal joint of the thumb is marred by Arthritis it is known as Basal Thumb Arthritis.
Arthritis is a disease or a debilitating condition which destroys the joint by affecting or damaging the cartilage which surrounds the end of the bones which enables them to glide and move smoothly.
It is difficult to ascertain the exact reasons why Basal Thumb Arthritis strikes but among the probable reasons are growing age more so after 40, previous trauma or injury sustained by the thumb or joint laxity. Women more than 40 are more susceptible to this conditional trauma.
The most common sign that indicates basal thumb arthritis is a deep, aching pain at the base of the thumb while grasping, gripping or pinching an object and application of force by the thumb. Other visible signs are swelling, stiffness and lack of motion. Enlarged appearance of the joint at the base of the thumb is another significant sign.
Some factors which increase the risk are:
- Patient being female in gender and more so above 40
- Obesity
- Any hereditary disease regarding joints
- Prior fractures or injuries to the thumb
- Activities that put extreme repeated pressure on the thumb
- Presence of Rheumatoid arthritis/osteoarthritis
After a thorough physical examination and looking out for noticeable lumps and swelling the orthopedic might move the patient's thumb with pressure towards the wrist joint to look for a crackling kind of sound to determine the wearing down of cartilage. To further the prognosis imaging tests like X-rays are recommended to determine the exact nature and extent of damage.
Thumb arthritis is treated by both nonsurgical and surgical techniques depending on their severity.
Nonsurgical techniques comprise of oral medications, corticosteroid injections and splint to support the joint and immobilize it for a fixed period to limit its movements. When all conservative methods fail to provide relief to both enervating pain and mobility then the surgeon adheres to surgical techniques which might be any one of the following-
- Joint fusion (arthrodesis)
- Osteotomy
- Trapeziectomy
- Joint replacement (arthroplasty)
Once the surgery is performed, the orthopedic will put the thumb or wrist in splint for a few weeks to enable healing.


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Current online Specials
August- enjoy 10% off all August AC Room bookings when staying 2 or more nights- use promo code "AUG10"
October- enjoy early bird rates on bookings in self contained rooms (AC or ceiling fanned) when staying 2 or more nights- use promo code "OCTOBER''
November- stay 5 nights and pay only 4 in November by using our promo code online "STAY5NOV"
or just enjoy early bird savings when booking for november between now and September 19 - code "EARLYBIRDNOV''
*specials are valid only for new bookings . Can not be applied to existing bookings or ammended bookings. Concurrent specials can not be used together, specials can not be used to redeem cash or refund.
30th April
Our latest project is finally almost done! New Lounge area for a our guests to relax and enjoy the breeze and view has just been completed! Trying to make use of our great location and get our guests a little closer to the water! All that is left now is rennovating of the deck on either side of this lounge (bar deck and restaurant deck) so hoping this will all be complete within the next few weeks! Sneak preview below


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Centerbrook's Academic Design Recognized
CENTERBROOK, Conn. – Centerbrook has received an award for Best Sustainable Design from the Connecticut Real Estate Exchange for its work at Quinnipiac University's York Hill Campus in Hamden, Connecticut. Led by partner Jefferson B. Riley, FAIA, Centerbrook has been designing the various buildings and infrastructure at the new campus for more than five years. The Blue Ribbon Award was for the Crescent Residence Hall, Rocky Top Student Center, and parking garage.
Located on a hill with views to Long Island Sound, York Hill encompasses a 2000-bed student village, the TD Bank Sports Center for Division 1 hockey and basketball teams, the student center, a parking garage, and a wind terrace of 25 vertical-axis turbines that power site lighting while also serving as a kinetic sculpture gallery.
The campus is designed to teach students about responsible development by mitigating the environmental impact of a major expansion. Twenty percent of the power is provided through clean, on-site energy. In addition to wind power, Centerbrook designed an array of sustainable features into York Hill. Solar photovoltaic panels provide electricity, and a geothermal ground-source heat pump assists with heating and cooling. The new 85,000-square-foot Rocky Top Student Center houses a highly efficient, gas-fired cogeneration micro-turbine that produces both electricity and heat for the campus. Other green approaches include water- and maintenance-efficient landscaping and plumbing fixtures, maximum use of on site materials, and storm water management and treatment.
York Hill is one of three campuses at Quinnipiac University, which has a total enrollment of 5,700 undergraduates and 2,500 graduate and law school students. The award was presented at the organization's annual Blue Ribbon Awards Showcase, which honored six other recipients.


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ATLANTA -- Georgia State ace Hunter Gaddis was named to the All-Sun Belt Conference baseball team for the second straight year, earning second-team honors.
The junior right-hander leads the Sun Belt with 112 strikeouts, which ranks No. 14 in NCAA Division I and is the second-highest total in Georgia State history, just four behind the GSU record of 116. Gaddis struck out 10 or more in four games, including his last two starts against Louisiana (11) and Georgia Southern (10).
Although he was credited with only one win, he took a lead into the eighth inning in four games that GSU was unable to win, and he received two or fewer runs in seven of his 14 starts.
He was named Sun Belt Pitcher of the Week for the third time in his career after pitching eight scoreless innings with 10 strikeouts in a combined shutout of Appalachian State.
Through three seasons, Gaddis' career earned run average stands at 3.81, the lowest mark in Georgia State history, while his 277 career strikeouts rank second. He also ranks fourth in career innings pitched (266.2), sixth in games started and 10th in victories (14).
The Canton, Ga., native is expected to be drafted in next month's Major League Baseball First-Year Player Draft.


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Are your uPVC windows, doors or conservatory looking a bit tired, grubby and discoloured?
Would you like them to look like new again, adding considerable value to your property, for a fraction of the cost of replacement or maybe you would like a whole new colour scheme?
Class One Decorating provides a painting service for uPVC , PVC and other hard plastic such as ABS, polycarbonate, acrylic and polyester powder coatings.
Our service also covers the painting of GRP (eg. composite doors), powder-coated aluminium and glass.
We utilise the cutting-edge technology and products developed by Kolorbond Paints. With the lower-quality products from other manufacturers, the paint sits on the surface and is only held by a weak mechanical bond, which is prone to failure after a relatively short time. The Kolorbond Paints system forms a molecular cross-bond with the substrate and is guaranteed, with the correct preparation and application, against adhesion failure for ten years and colour fade for five years.
Using a combination of the high-tech XVLP spraying system and expert brushwork, we can paint architectural plastics, both domestic and commercial, in any colour from the standard ranges such as RAL, BS4800, etc. We also provide an expert colour-matching service to the Farrow and Ball, Dulux, NCS, etc, ranges. If the customer requires a bespoke colour, a provided sample can be accurately matched to significantly within industry-standard specifications.


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Jeffrey P. Compton Attorney at Law serves clients throughout Central Ohio and the surrounding areas.
Please fill out the form below and one of our attorneys will contact you.
Grove City Office
3894 Broadway
Grove City, Ohio 43123-2207
Phone: 614-875-7233
Fax: 614-875-7207
Office Hours:
M - F 9:00 a.m. to 5:00 p.m.


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Hi, Hej, Olá,
I'm Pat.
On this site, you'll find my writings on some of my favourite things:
Decentralized, Distributed and Federated systems | Open Source Software | Digital Privacy | Artificial Intelligence | Product Development | Software Development | Cryptocurrency | Data Science | Product Management | InfoSec | Leadership | Decentralized Governance | Supply Chains | Ethical Design | Economics | Economic Empowerment | Plant-Based Lifestyle | Yoga | Woodlands | Trees | Jogging | Venture Capital | Capital Markets | Startups | Mandarin
You can also find me on Twitter, Medium, Linkedin and Github. You should join my (infrequent) email Newsletter for more content not published here.
The best way to contact me is via Twitter. Otherwise, drop a note here.
I'm now busy with own projects. Most recently hen.ai and creatorstory.
Through ExperiencEconomy, I provide advisory services.
Past: A fifteen years' career of global technology and business experience at both multinational organizations and startups across 4 continents (including Taiwan, South Africa, Brazil, Finland, Sweden and United Kingdom).
I am curious about everything, dig making really complex stuff simple and am a massive product geek. Being an Engineer and an Economist, I predictably (yes, I know…) became fascinated by decentralization and federation (i.e., I'll probably read - or skim - your white paper if I come across it). I'm specially interested in initiatives that help boost economic empowerment.
Otherwise, you'll find me with ∞ tabs open in my browser, eating 🌱 food, practicing yoga, jogging or enjoying the outdoors.


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| 5.9°C Belfast
GBP The Great British pound took a dive against the euro in the second half of the week, as new data cast a shadow of doubt over economic growth in the UK following a volatile week for the currency.
It was revealed that UK retail sales have fallen faster than analysts predicted, sparking fears that the UK economy is beginning to cool down.
With the Bank of England desperate to keep interest rates low, markets are pushing the pound back in order to meet these interest rate situations.
These figures were particularly worrying given that the UK's recovery has been in part due to consumer spending.
The US dollar, meanwhile, has enjoyed relatively little movement over the past week due to a mixed bag of data.
The American asset has generally been trending lower, with futures traders paring bets regarding when a Federal Reserve rate hike will occur.
However, on Wednesday the Greenback saw gains against a number of currencies thanks to positive domestic data.
The year-on-year Consumer Price Index was expected to drop from 1.7 per cent to 1.6 per cent. However, September's result held at 1.7 per cent.
In addition, mortgage applications in the US rose from 5.6 per cent 11.6 per cent, boosting the USD further.
The euro edged higher against the US dollar on Friday after the release of upbeat German consumer climate data.
Sentiment improved after it was shown the GfK German consumer climate index had increased to 8.5 in October - up from September's figure of 8.4. This is despite analysts forecasting the index would fall to eight this month.
Meanwhile, research group Markit said its preliminary Eurozone manufacturing purchasing managers' index rose to 50.7 this month after reading just 50.3 in September. Meanwhile, the region's services PMI stayed at 52.4 - slightly higher than expectations of 52.
The yen pulled away from two-week lows against the dollar on Friday after news hit that a doctor in New York had tested positive for the Ebola virus after returning home from West Africa.
This threw the market into turmoil due to the possible repercussions of the virus on the global financial centre.
Kaneo Ogino, director at Global-info Co in Tokyo, told the Daily Mail: "The volatile move was a good chance for some to buy the dollar on dips.
"I think, next week the market will be more event-driven, with the FOMC and the Bank of Japan, so the downside should be limited."
Belfast Telegraph


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Cloning a project is useful to create a backup, fork, or to rapidly scaffold client work for an agency work. Cloning will duplicate the project plan (in trial mode if a paid plan) and the project content but will not duplicate any custom roles or assigned roles.
General Project Settings card, on the bottom right, click
name and
description (optional), you will choose whether or not to also clone content, and which region you'd like your API served from.
Create will then migrate the data you've just defined, and you're done! Project cloned!
Cloning via the mutation API is also a possibility. You need to define the
ID of the project you want to clone, the target region where the new project will be hosted and the name of the new/target project you want to create. You can optionally include a description and a boolean flag for whether or not to include the source content.
Cloning a project is only possible via the management API. For more information on how to work with the Management API, please read the Management API documentation.
mutation {
data: {
id: "9ea9dfaec82b4ab085788636b710195a"
name: "Bergen"
description: "The Mountains Project Clone"
region: "US East"
includeContent: true
) {


text:
"For Inspired Living"
"For Inspired Living"
Pure Heart Spiritual Center "For Inspired Living" has a simple goal and mission: To create, foster and maintain spiritual community and connection; attracting Pure Hearted people on a path of spiritual growth and discovery while we support, promote and provide heart centered events, retreats, blogs, articles, healers, products and books to help those on this journey towards peace, inclusion, wholeness and oneness.
Pure Heart Spiritual Center works, Locally, Regionally, Nationally and Globally to assist those who are seeking to commune with other like-minded (like-hearted) people and, also to foster compassion and, tolerance towards those who seem different. We believe that ultimately we are all "One" acting as different expressions of the "One" many of us call God.
"Never say I have found THE truth, but rather, that I have found A truth"...Kahlil Gibran~
At Pure Heart Spiritual Center, we do not adhere to any special doctrine, religion or faith. We see ourselves as all inclusive and can either serve as a spiritual path or an addition to the one you currently walk. We at Pure Heart Spiritual Center DO NOT exclude anyone from enjoying our content. If you are guided to this site, most likely there is something here for you.
We hope to lead you towards the expansion of your spiritual perspectives and growth in a supportive online and in-person environment.
Check out our site to familiarize yourself with happenings, meet-ups, retreats and events everywhere, so that you can meet like-minded people who are growing in meaningful spiritual ways. We offer a number of interesting options to help you stay on the Spiritual Path and to have fun and feel supported while doing so. We have new postings and events daily, weekly and monthly. To stay posted on what's new, you may want to check in often or sign-up for email notifications, it's up to you!
To submit a great resource like a favorite spiritual book, vegan recipe, meditation, daily meditation practice advice, favorite spiritual center near you, favorite rock/crystal shop, favorite healer, favorite alternative medicine or any other fun addition to our site, we are open as we are building a spiritual community globally and want to be as informative as possible.
Please submit your suggestion to: email@example.com
Include the most information about the product or place as possible including a link and why it is a favorite of yours. We will review it and consider it for posting, no guarantees, but all submissions are appreciated, thank you!
We at Pure Heart Spiritual Center "For Inspired Living" want to hear about your community organization be it large or small, how did you decide to make a difference for others where you live?
We want to publish your story on this site, to help others know that they can make a difference too, submit your story today! firstname.lastname@example.com
By our definition a social activist is someone who is "actively seeking social justice and equality among others". Does this sound like you? If so, please tell us how you are working to effect positive social changes in your community, nationally or globally.
Submit your story to:
Do you lend a hand and help others feel empowered? Are you a Mentor, Teacher, Minister, Healer, Leader? What you are doing and creating to empower yourself and others. Tell us how you are making a difference to inspire others.
Sign up to hear from us about specials, sales, and events.


text:
Half Angle Calculator
Half Angle Identity Formulas are those that express the trigonometric functions of half an angle in terms of trigonometric functions of the angle. Half Angle formulas are useful in finding the values of unknown trigonometric functions.
Half Angle Identity Calculator
Enter θ angle in degree:
Half Angle Formula
Equations used in Half Angle Formula calculator are below:
sin( θ / 2 ) = √ 1 - cosθ / 2
sin( θ / 2 ) = √ 1 + cosθ / 2
tan( θ / 2 ) = 1 - cosθ / sinθ
half angle identity calculator
Special cases of the sum and difference formulas for sine and cosine yields are known as half angle identities. The advanced online Half Angle Identity Calculator is used to calculate the exact value of half angle identities for the trigonometric values.
Related Calculator
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Bernoulli Inequality
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Trapezium Calculator
Hemisphere Calculator
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nTimer Web Solution Pvt. Ltd.
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text:
Fast fashion retailers have faced a difficulty in translating in-store experiences to online experiences. Although online shopping is increasing, the in-store shopping is still very important for a superior shopping experience. Technology has had a major impact in making multichanneling retail more consistent, although there are gaps that technology can not fill.
This study attempted to measure how consistent the customer experiences were online and in-store. Shopping experiences were measured with different concepts such as: flow, usability, interactivity, atmospherics and tactility. These concepts were measured separately in-store and online, in order to be compared. The purpose was to find out which concept is inconsistent so the authors could make recommendations for improvement to fast fashion retailers. The research approach was a mixed method approach and the chosen research design was cross sectional, using quantitative research to corroborate qualitative research findings.
The results from a quantitative questionnaire of 263 experienced fast fashion consumers in Sweden show that the consistency varies between the concepts. The qualitative study was done at two occasions on a sample of six interviewees in each focus group, and gave a deeper understanding for why the shopping experience was or wasn't consistent. The qualitative results varied amongst the individuals and show that reasons for being inconsistent are intrusive salesmen, insufficient size measuring tools, long queues, lack of tactility and the most interesting of all: making better return and ordering policies.
The future lies in making it easier to order online, in order for the consumer to be able to experience the product in real life, through staff-free fitting rooms and showrooms and such, rather than making the experience better online. The future seems to lie in solving the reverse of the start point of this study, namely translating online to in-store experiences.


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All eyes were on Brooklyn's game because a majority of the Isles starters were taking part in that game and it was their first real run-through in their new home. Here are few things we learned from Monday's game at Barclays Center...
- Brian Erni talked about it this morning, but it is worth again talking about Kirill Petrov's impressive night. The Russian forward made his presence known throughout the night and did not look out of place alongside Nikolay Kulemin and Mikhail Grabovski. It was only one game, but Petrov has looked better and better each day of camp. He had a sluggish start on day one, but if he can keep up strong, consistent efforts, like the one he had on Monday, he could work his way into the opening night roster conversation.
- The ice was a topic of conversation before and after the game. At the end of the day, the ice seemed to pass the first of many tests it will face this season. It did appear to get choppier as the game progressed -- something captain John Tavares mentioned after the game. Aside from it being the first game of the season in Brooklyn, the arena hosted a Madonna concert just two days before, which affected the ice quality. Again, the ice got a passing grade, but it will be a part of the narrative for the first few weeks of the regular season as Barclays Center continues to work out the kinks.
- Some habits die hard for the Islanders. They surrendered a late goal at the end of the second period to end their bid for a preseason shutout, with Taylor Leier scoring for the Flyers to cut the Islanders' lead to 3-1. New York won the game, so it was not entirely like last season, but it sure did give fans some nightmarish flashbacks.
- It was only the first preseason game, but the power play scored twice for the Islanders. Head coach Jack Capuano noted that the team shot pucks on net during the man-advantage, which capitalized twice during the evening. It was a positive to see the special teams work effectively, but again it's only the first preseason game.
- Brett Yormark has proven that he has taken notice to Islanders fans on twitter. During a chat with a small contingent of Islanders beat writers, Yormark told them that Barclays Center had originally intended to re-brand the team. However, he quickly realized it was the wrong decision after hearing from fans. It also likely played into the about-face they did with the team's divisional and conference championship banners that will now also hang in the rafters in Brooklyn.
- Two other notes from that meeting were the breakdown of ticket sales. Yormark told reporters 33 percent of ticket plan sales have come from Manhattan and Brooklyn, with another 30 percent coming from Nassau and Suffolk Counties. Yormark also mentioned that they will announce the team's new radio deal later this week.


text:
In area, a little smaller than Connecticut.
Main Languages
Arabic, French, English, Armenian
At 6:00 a.m. U.S. Central Standard Time, it is 2:00 p.m. in Lebanon.
Lebanon gained independence from France in 1943. A civil war from 1975 until 1990 destroyed many lives and much property. Tensions and violence have continued off and on.
In the 1940s, the majority of the people in Lebanon were Christians. By the 1970s, Muslims had become the majority. Muslims began to demand an equal part in running the country. When they did not think their demands were being met, a civil war began. Many thousands of people were killed during the war. Today more than half the people in Lebanon are Muslims.
The constitution of Lebanon says that citizens are free to follow the religion that they choose. Persecuted Christians from nearby countries sometimes seek sanctuary in Lebanon. The main danger to Christians is from radical Muslims among the citizens. In addition, Muslims who leave Islam to follow Jesus are persecuted by their families and other Muslims.


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Page 1 of 14 Drug Discovery Pipeline Brief Report 2011 Executive Summary The Drug Discovery Pipeline (DDP) was established in 2009 at the Guangzhou Institutes of Biomedicine and Health (GIBH). The mission of the DDP is to capture the best ideas developed within GIBH and translate those ideas into drug discovery projects. Prior to the creation of the DDP, there was no mechanism in place to transform concepts into drug discovery projects. However, after the formation of the DDP, GIBH now has the required expertise, platform technologies, centralization and necessary integration of disciplines to enable effective drug discovery research, which is not found at most institutes in China. Since its inception the DDP has achieved five important milestones, which include: (1) Centralization of key technology groups to support drug development; (2) Integration of project teams to enable the advancement of drugs; (3) Development of a sustainable pipeline of projects with novel intellectual property (IP); (4) Establishment of key international partnership for the co-development of drugs; and (5) Creation of new companies in Guangzhou using IP matured in the Pipeline. A 6th milestone, which includes advancing a new drug into clinical trials, is expected to be achieved in late 2012 /early 2013. I. Centralizing the key technology groups In order to effectively develop drugs at GIBH, it was necessary to first create and centralize several technology groups including High Throughput-Screening (HTS), Structural Biology, Pharmacokinetics (PK), Biomarkers, Medicinal Chemistry and BioTherapeutics. All of these groups have been established and are led by experienced senior scientists, many of who have strong drug discovery experience (Figure 1). Progress Report 2011 DDP Page 2 of 14 Figure 1: Structure of DDP Micky Tortorella (CTO) Administration 3 FTE* Chemistry Biology (Donghai Wu) (Zhengchao Tu) PK/ADME (Xiaorong Liu) Structure (Jinsong Liu) Biomarkers (Scott Spillman) 18 RA* 11 RA 5 RA 9 RA 1 RA 2 RA *FTE=Full Time Employee • HTS (Ding Ke) BioTherapeutics (Daiguan Yu) 2 RA RA=Research Associate HTS – This team is capable of screening thousands of compounds per week in various enzyme and cell based assays at a low price using new automated robotic equipment purchased in 2010. At this time the group has screened several thousand compounds and identified lead molecules for several drug discovery projects at GIBH in the areas of cancer, inflammation and infection (Table 1). Table 1: Productivity of High Throughput Screening. Targets(Related diseases) Protein Kinases ABL (CML) ABL (T315I) (CML) Abl(E255K)(CML) ABl(G250E)(CML) Abl(Y253F)(CML) ABl(Q252H)(CML) ABl(H396P)(CML) ABl(M351T)(CML) ALK(Cancer) Kit (GIST) (Cancer) EGFR (Breast and lung cancer) Progress Report Hits identified 351 351 231 231 231 231 231 231 5 231 347 2011 DDP Page 3 of 14 EGFR (T790M) (Breast cancer) EGFR(L858R)(Breast and lung cancer) EGFR(T790M&L868R)(Breast cancer) EGFR(L861Q)(Breast and lung cancer) Her2 (Breast cancer) AKT1(Cancer) AKT2 (Cancer) AKT3 (Cancer) Proteases DPPIV (Diabetes) DPP8 (Diabetes) DPP9 (Diabetes) NS3/4A (HCV) Furin (virous infection) Other molucular targets Neuraminidase S (Influenza) Neuraminidase S (Influenza) COX-1(Inflammation and RA) COX-2(Inflammation and RA) HDAC1(Cancer) HDAC7 (Cancer) Cell-based infectious diseases Influenza Ev71(Enterovirus infection) 347 305 305 305 84 35 35 35 50 17 38 1 1 32 32 1 1 15 15 62 1 • Structural Biology – The group is currently supporting the lead optimization of compounds for several drug discovery projects. The support they provide to the DDP include the expression of protein, crystallography, computer-aided drug design and high-throughput virtual screening. The team recently developed a new super computer platform, capable of virtually screening ~40M compounds per target. The team is enabling the design of inhibitors targeting ADAMTS4/5, p38 alpha, beta, delta, gamma, cKIT/AKT1/EGFR, Plasmepsin II/IV/V and G1B. • Pharmacokinetics/ADME – The team provides data regarding the drug metabolism, pharmacokinetics and acute safety of our lead compounds. These data are critical for the prioritization and development of new pharmaceutical drugs at GIBH. Currently the capabilities of the team include standard pharmacokinetics, blood brain barrier penetration, acute toxicity in rodents, metabolic stability of compounds, plasma protein binding of drugs, drug-drug interactions, Caco2 and Zebra fish toxicity. The team has analyzed over 100 compounds for the DDP, allowing the project teams to optimize and advance lead molecules in a timely manner. Progress Report 2011 DDP Page 4 of 14 Table 2: Productivity of Pharmacokinetics Analysis Number of Compounds Tested Pharmacokinetics 85 CNS penetration 7 Acute toxicity 10 Metabolic stability 35 Protein binding 28 Caco2 21 Drug drug interaction 81 Zebra Fish (Toxicity) 16 Rat air pouch inflammation model Drug toxicity in rat 2 Human hepatocyte culture 2 4 • Biomarkers - In collaboration with Plexera, novel biomarker based chips for rapid detection of thousands of proteins in the blood are being developed. The chips will be used as diagnostics to determine the safety and efficacy of our lead candidate drugs by monitoring the modulation of selected biomarkers in bodily fluids such as urine, synovial fluid and plasma. At this time the team has identified novel chip surfaces to reduce background and chip to chip variation . • Medicinal Chemistry – The newly integrated chemistry team has and is currently designing novel drugs in several different therapeutic indications. The group has made several hundred proprietary compounds targeting pathways in cancer, inflammation, infection, arthritis and metabolic diseases. Table 3: Productivity of Medicinal Chemistry Project/Traget Cancer Arthritis Alzheimer's Diabetes Flu Malaria Pain Progress Report Number of compounds made 300 100 200 100 120 6 6 2011 DDP Page 5 of 14 • BioTherapeutics – Protein based therapeutics with an ephasis on proteases are currently being developed for the treatment of various blood disorders. Proteases are naturally occurring peptide-cleaving enzymes that regulate a wide variety of biological functions. In the DDP we are using the potential of these enzymes as bio-therapeutics by directing them to cleave specific proteins in the blood that promote health. Unlike standard drugs, a single proteinase molecule can inactivate or activate thousands of target molecules, resulting in higher efficacy and lower dosing regimens compared to small molecules or antibodies. Currently, the team is expressing a more active species of ADAMTS-13 for the tratment of thrombocyopenic disorders. II. Integration of project teams to enable the advancement of drugs To effectively enable drug development at GIBH, the DDP has been organized using a very different model that is not traditionally found at other institutes in China. In the DDP, there are no individual principle investigators (PIs) working in isolation. In contrast, all senior staff and corresponding reseacrh associates work in teams supporting specific projects that are deemed high priority. The DDP operates under a "Project" rather than "PI" centric system. The integration of medicinal chemistry and biology has been successful and current project teams are able to provide the critical mass and expertise needed to advance drugs and cultivate new intellectual property (Figure 2). Figure 2: Model of the "Project Centric" system employed in the DDP Project Chemistry Leader Biology Leader Team Members Protein Screening Enzymology Biomarker validation Animal models PK/ADME Safety Progress Report Team Members Molecule design Synthesis Purity Crystallography Scale-up Formulations 2011 DDP Page 6 of 14 III. Development of a sustainable pipeline of projects with novel intellectual property After only one and a half years after its inception, the DDP has cultivated a porfolio of drug targets that enjoy strong intellectual property. Current programs are developing drugs to treat Alzheimer's disease, leukemia, inflammation and infectious diseases. Two projects are at candidate selection, one project is at lead optimization, three projects are at hit identification and several projects are at early exploration (Table 4). Table 4: Pipeline of projects and estimated time to IND filing. Disease Leukeumia Alzheimer's Target Mutant forms of the Bcr-Abl Kinase Neural Inflammation Aggrecanase Stage Candidate Selection Joint Inflammation Inflammatory Genes Candidate Selection Lead Optimization Lead Optimization Malaria Plasmepsin V Hit Identification Osteoarthritis Thrombocyopenic Disorders Pain and Cancer ADAMTS-13 Early Exploration (Protein Therapy) COX-2 Hit Identification IP Compound, D824, a new kinase inhibitor Compound, HWH-2-130 Carboxylate inhibitors AS001: siRNA/Particle conjugate New aspartyl protease inhibitors ADAMTS-13 protein constructs Novel chromene inhibitors Time to IND 2012 (Oral, Small Molecule) 2012 (Oral, Small Molecule) TBD (Oral, Small Molecule) 2013 (Local Injectable) TBD (Oral, Small Molecule) TBD (Protein, IV) TBD (Oral, Small Molecule) *TBD = To Be Determined Summary of DDP projects expected for IND filing in 2012/13 1. Research and Development of a New Drug for the Treatment of Drug-Resistant Leukemia (Project Leader is Dr. Ding Ke) Background and Medical Need: Chronic myelogenous leukemia (CML) has a high mortality rate of 20%-30%, two years after a confirmed diagnosis. Approximate 25% of patients with CML die every year and the average survival time is just 3 to 5 years. The age of onset ranges from 20 to 50 and in China, there are 30,000 new cases diagnosed each year. Gleevec therapy alone can alleviate the condition in many patients suffering from CML. However, because of extensive usage of Gleevec, it is becoming less effective. Some CML patients are inherently resistant to Gleevec, and some respond to Gleevec in the beginning, but acquire secondary resistance over the course of the treatment. Progress Report 2011 DDP Page 7 of 14 Rationale for the Approach: The major cause of resistance to Gleevec is a secondary mutation in the kinase domain of target gene expression products. Research indicates that the common point mutation sites related to Gleevec resistance include E255K, E255V, T315I and D276G of Bcr-Abl and D816 of c-KIT. The Bcr/Abl, T315I mutation, one of the obstinate drug-resistant mutations is the most common mutation, representing about 20-30% of all cases. The clinical drug resistance mediated by the T315I mutation of Bcr-Abl remains a significant medical problem and at this time there are no drugs targeting the T315I point mutation on the market. As a result, it is urgent to develop novel drugs for the treatment of this type of drug-resistant leukemia. Validation of Lead Chemistry: Using the principles of rational and computeraided drug design, the project team has successfully designed and synthesized a series of leading compounds with strong intellectual property. In vitro data show that the novel compound, D824 has an activity 1000 times more potent than Gleevec on chronic myloid leukemia cells containing no mutations, but more importantly exhibits excellent activities on all cell lines that are resistant to Gleevec treatment. This series of compounds has excellent activities against the T315I mutation found in the Bcr-Abl kinase active site, which cannot be treated with current drugs. Domestic and international data report that neither the first-line drug Gleevec or the second-line drugs Dasatinib or Nilotinib (approved by FDA for the treatment of CML) are effective in patients with the T315I mutation, because their IC50 values all exceed > 50 µM. The IC50 of D824 is <10 nM and its activity is 5,000 times more active than current clinical therapeutic drugs. D824 was found to be efficacious in a rodent model of leukemia as well as models that measure solid tumors. Toxicity and pharmacokinetic experiments indicate that D824 has a reasonable safety index with excellent pharmacokinetic properties such as oral bioavailability and a very lon half-life, all within range for the requirements of a new drug. 2. Research and Development of a New Drug for the Treatment of Alzheimer's Disease (Project Leaders are Wenhui Hu and Donghai Wu) Background and Medical Need: Alzheimer's disease (AD) is a major health and societal problem. It is extremely costly to the patients, their families and to society as a whole. In 2007, it was estimated that $100 billon was spent in the United States on health care expenses and lost wages for AD patients and their caregivers. Further estimates predict that $375 billion will be spent annually by 2050. Unfortunately, AD drug discovery has been disappointing as no disease modifying drugs are available. Current drugs used to treat AD only treat the symptoms of the disease. Rationale for the Approach: Alzheimer's disease is characterized pathologically by the deposition of amyloid fibrils and neurofibrillary tangles in the brain. Many biochemical and genetic evidence heavily favors the "amyloid-β hypothesis" (Figure 3) . However, new data suggest that neuroinflammaiton may play a bigger role than previously thought in the development of the disease. The goal of the DDP is to advance inhibitors that block neuroinflammation as a means for attenuating the Progress Report 2011 DDP Page 8 of 14 progression of AD. Minozac, discovered by Dr. Wenhui Hu was one of the first drug candidates designed for blocking neuroinflammation, representing a new class of compounds for the treatment of Alzheimer's disease. Recently, his team has discovered several new and highly potent inhibitors of neural inflammation with superior properties compared to the original lead molecule, Minozac. Validation of Lead Chemistry: The new series of compounds are thousands of times more potent than Minozac in variuos cell based assays of neural inflammation. The compounds are drug-like candidates as they possess excellent PK properties without apparent acute toxicity in rodents (safety index up to 1000x the efficaious dose). In addition, lead compound, HWH-2-130 has demostrated significant efficacy in several in vivo models of Alzheimers disease , stroke and rheaumatoid arthritis. IND filing is anticipated in 2012 pending chronic safety evaluation. Figure 3: Model of neural inflammation in AD. 3. Research and Development of Anti-Osteoarthritis and Anti-Rheumatoid Arthritis siRNA Drugs (Project Leader is Dr. Biliang Zhang) Background and Medical Need: Osteoarthritis (OA) is one of the leading causes of disability in the world, with more than 10% of the elderly population having symptomatic disease. Rheumatoid arthritis (RA) is a chronic, inflammatory disease that affects approximately 0.5 to 1 percent of adults worldwide and commonly results in joint destruction and significant impairment in the quality of life. Many pathogenic pathways of OA and RA have been revealed recently, which led to development of various novel therapies. During the past 20 years, most of the development of new therapies is in disease-modifying anti-rheumatic drugs (DMARDs) and disease modifying osteoarthritic drugs (DMOADs), especially biological DMARDs. With the discovery of new pathways and the application of drug delivery strategies, more growth is anticipated in this therapeutic field. Thus, significant opportunity exists for agents such as siRNAs that can stop or reverse disease progression and act as disease-modifying agents. Progress Report 2011 DDP Page 9 of 14 The current treatments of RA include 4 categories: non-steroidal antiinflammatory drugs (NSAIDs), glucocorticoids, non-biologic disease-modifying antirheumatic drugs (DMARDs) and biologic DMARDs. Till date, the pharmaceutical industry has failed to bring effective and safe disease modifying osteoarthritic drugs (DMOADs) to the millions of patients suffering from this serious and deliberating disease. RNA interference (RNAi) is a revolutionary discovery in life science and has become a powerful tool for studying the gene function, which mediates gene inactivation in organisms, mammalian cells and even animals. RNAi technology has the potential to create new therapies in humans including anti-OA and RA therapies. In this project, we are developing novel slow-releasing siRNA drugs as anti-OA and RA therapies. Rationale for the Approach: RNA interference has not only become a standard method of molecular biology—it has already made its way into the clinic. Around a dozen clinical studies based on RNAi are curently in progress and the initial results are promising. RNAi technology can be used against any disease in which a deleterious gene is over-expressed (for example, cancer, viral infections, inflammation). The advantage of employing RNAi in drug discovery is speed; progressing from target identification to preclinical evaluation can occur in as little as 6 to 9 months. However, the delivery of the siRNAs into cells presents one of the greatest challenges in the development of new RNAi therapies. The goal of this project is to develop a universal formulation for delivering anti-arthritic siRNAs locally via intra-articular injection into the joints of patients. Since articular cartilage and the surrounding synovial fluid (SF) is highly negatively charged, a formulation employing postively charged nano-partciles maybe an effective strategy for delivering anti-arthritic siRNAs selectively to the diseeased joints for a sustained period of time after only a single injection. Validated siRNA Targets and Delivery Formulation: A series of siRNAs have been made targeting key genes implicated in both osteoarthritis and rheumatoid arthritis including TNFα, ADAM-17, ADAMTS-5, PACE4, JAK3, CD44, CD36, NF-kB and RHAAM. The active siRNAs were screened against each gene in vitro. The IC50 has been determined for each individual active siRNA using synovial fibroblasts. The most active siRNA showed an IC50 as low as 10 pM. A proprietary formulation that uses positively charged particles to deliver the oligonucleotides has been identified. The major components of the formulation is a co-polymer with a low molecular weight polycation and a biodegradable polymer. The positively charged co-polymer can form nanoplexes or nanoparticles with siRNAs and these nanoplexed-siRNAs can effectively penetrate into synovial fibroblasts and supress the expression of inflammatory genes implicated in both OA and RA (Figure 4). IND filing is anticipated in 2013 pending chronic safety evaluation. Progress Report 2011 DDP Page 10 of 14 Figure 4: Bio-surgery concept for the treatment of inflammatory arthritis. IV. Establishment of key international partnership for the co-development of drugs In order to enhance the drug discovery efforts at GIBH, the DDP has established several international partnerships with premier scientists and institutions in the United States with the mission of co-developing drugs. Our international partners offer experience and innovation in drug discovery. In addition, these collaborations allow GIBH to share the risk and expenses associated with drug development. Currently, GIBH has two external partnerships with (1) The Center for World Health & Medicine at Saint Louis University to develop anti-malaria therapies and (2) Legacy Pfizer scientists to advance novel chromene based inhibitors of COX-2 that spare both the renal and cardiovascular risks associated with current celecoxibs (Figure 5). Progress Report 2011 DDP Page 11 of 14 Plasmepsin V Inhibitors for Malaria 3rd Gen. COX-2 Inhibitors for Dental Pain and Cancer The Center for World Health & Medicine, Saint Louis University Legacy Pfizer Scientists GIBH GIBH Washington University Figure 5: External partnerships at GIBH 1. Inhibitors of Plasmepsin V as Novel Anti-Malarial Agents (Project Leaders at GIBH are Xiaoping Chen and Ding Ke) Project Summary and Proposal Each year there are approximately 350-500 million cases of malaria, killing between one and three million people, the majority of whom are young children in subSaharan Africa, where ninety percent of malaria-related deaths occur. Although there are a number of drugs used to treat malaria, resistance to these drugs is becoming more widespread. Thus, therapies targeting novel modes of action are greatly needed. One promising new antimalarial target is the Plasmodium specific aspartyl protease, Plasmepsin V (PMV), recently discovered to be the key gate keeping protease responsible for the cleavage and translocation of several hundred PEXEL-containing proteins destined for export into the host erythrocyte. PMV and many of these downstream PEXEL-containing export proteins are essential for the survival of the parasite (Figure 6). The aim of this project is to identify potent inhibitors of PMV and demonstrate their therapeutic value for the treatment of malaria. Progress Report 2011 DDP Page 12 of 14 Figure 6: Life cycle of P. falciparum Project Progress HIV-1 aspartyl protease inhibitors lopinavir, ritonavir, saquinavir, and nelfinavir have been demonstrated to be weak inhibitors of PMV (~15-100 µM). This is not surprising, given the distant homology of PMV to other aspartyl proteases such as βsecretase and similarities between the PEXEL sequence in substrates for PMV and protein substrates of HIV-1 aspartyl protease. However, with molecular weights exceeding 700 and weak potencies, these HIV protease inhibitors are not good starting points for optimization towards an anti-malarial drug. Our approach to identifying a more suitable starting point for optimization involves screening collections of aspartyl protease inhibitors to be secured from commercial, literature, pharmaceutical donors, and our internal medicinal chemistry program . Recently a set of BACE-1 inhibitors has been identified as active agents against PMV and are being used as starting points for further optimization. The Center for World Health & Medicine, Saint Louis University (www.cwhm.org) The CWHM is a non-profit group whose expertise is the translation of basic science into the discovery and development of novel drugs for rare and neglected diseases. The CWHM consists of a highly skilled and successful team of former Pfizer drug discovery scientists. The scientists on this team have expertise at high throughput protease assay development, drug design and medicinal chemistry, in vivo pharmacology and pharmacokinetics, and preclinical development. 2. Chromene COX-2 Inhibitor Project (Project Leader at GIBH is Yanmei Zhang) Project Summary and Proposal The chromene pharmacophore represents a novel drug class of COX-2-selective inhibitors (coxibs) that have a carboxylate moiety and do not bind in the hydrophobic binding pocket of the COX-2 active site. As a class, they have been shown to confer Progress Report 2011 DDP Page 13 of 14 potency, efficacy, and selectivity on par with the diaryl heterocyclic coxibs (eg, celecoxib, valdecoxib, rofecoxib, and etoricoxib) in the standard rat models of inflammation and pain. The chromene coxib clinical candidate, SC-75416, was shown to be differentiated from the diaryl heterocyclic coxibs in that it conferred reduced tactile allodynia in a rat model of neurophathic pain. A testing scheme has been implemented and the synthesis of novel and potentially superior chromene coxib analogs has been initiated. The chromene pharmacophore may prove to provide advantages over the existing coxibs for the treatment of inflammation and pain, especially for those patients who are inadequately served by the analgesic medications available today. As a class, the chromene coxibs have the potential to be renal-sparing and thereby mitigate coxibinduced hypertension due to their intrinsic and distinct structural, pharmacological, and physiochemical properties. These combined properties, if borne out, could allow Chinese sFDA approval, as well as world-wide approval, including the United States, with first-in-class and best-in-class status. The overall goal is to (1) identify novel and potentially superior chromene coxibs for the treatment of acute and chronic pain/inflammation and, possibly, cancer. (2) The initial goal is to identify a chromene coxib clinical candidate within 18 months for the treatment of acute dental pain in China. Acute dosing (i.e., ≤7 days) will be targeted initially in order to avoid the cardiovascular side effects (i.e., hypertension, edema, myocardial infarction, and stroke) associated with chronic dosing of some coxibs (e.g., rofecoxib). (3) In parallel, the renal- and hypertension-sparing properties of the lead chromene coxibs will be evaluated. (4) Chronic indications of pain and inflammation (e.g., OA and RA) in China will be explored if the clinical chromene coxib candidate is renal- and hypertension-sparing. Project Status A testing scheme has been implemented to identify novel and potentially superior chromene coxib analogs. The chromene analogs, SC-75416 (R/S), 29b (R/S), and 34b (R/S), and celecoxib are being synthesized as comparator coxibs. The synthesis of novel and potentially superior chromene coxib analogs has been initiated. Distinguished scientists partnering with GIBH Dr. John Talley is an inventor and researcher with over 25 years experience with a broad background in organic and medicinal chemistry and an inventor of the COX-2 inhibitor, celecoxib (Celebrex™) and valdecoxib (Bextra™). Dr. Mark Obukowicz was a Senior Research Fellow at Pfizer Global Research and Development with >26 years experience in drug discovery and the discoverer of novel chromene, selective inhibitors of COX-2. V. Creation of new companies in Guangzhou In addition to drug development, a key mission of the Pipeline is to create spinoff companies based on intellectual property cultivated in the DDP. This will serve several purposes. First, it will ensure a focused effort on the development of lead drugs Progress Report 2011 DDP Page 14 of 14 into clinical trials; second, it will share the burden of drug discovery, cost and risk across GIBH and the new companies it creates; and third, stimulate the local economy in Guangzhou by employing people and investing in the local community. Establishment of local satellite companies will increase the scientific excellence within the city of Guangzhou and spur regional growth in the area of biotechnology. Currently the DDP has mediated the spin-off of two small companies in Guangzhou city including GZstem and Argo Biopharmaceuticals. 1. GZstem, Inc. GZstem, is a stem cell based company funded by the US Corporation, Sigma Aldrich. The product line of the company consists of 1. Induced pluripotent stem cells (iPSCs), derived from tissue of normal and diseased human specimens (25 lines currently available); 2. Protocols for directed differentiation of iPSCs, into different cell lineages; 3. human iPSCs containing reporter genes. GZstem employs 10 full time scientists with a total operating budget of ¥8.5M/yr. 2. Argo Biopharmaceuticals Argo Biopharmaceuticals is a technology based company funded by both a venture capital firm and the local government. The product line of the company is siRNA based therapeutics using novel nano-particle delivery systems. Argo Biopharmaceuticals employs 8 full time employees with a total operating budget of ¥6.5M/yr Progress Report 2011 DDP
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Oil, Gas & Industrial Projects
Safe project execution
Blue Water Houston has recently executed multiple RTG and Ship to Shore Crane Transport contracts
Part of the contracts covered the transport of eight RTGs (Rubber Tire Gantry) on one barge. This specific job included the passage of the Panama Canal. A lot of preparation had to be done prior to the actual transport. This included engineering work, route planning and much more.
Blue Water Houston offers a true turnkey solution, in competition with carriers and crane companies, for crane preparation, transportation and limited restoration to terminal owners and stevedoring companies throughout the USA. Our in-depth knowledge of US Jones Act compliance enables us to provide unique solutions with a variety of vessels and barges. We also have started quoting for international transports of these large units and are competing for salvage contracts as well.
Blue Water Houston is a key office, in Blue Water's global network of offices, providing transport and logistical services to projects in the Energy Sector. During recent years, the office has developed the competencies and services to customers not only in the US but worldwide.
"It is our subject matter experts who set us apart from the everyday forwarder. At Blue Water we are able to provide our customers with a wide range of expertise in project management, transportation engineering, shore base management and other verticals within Oil, Gas, Industrial Projects and Wind", states Senior VP Global Projects, Brent Patterson from Blue Water Houston.
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Image courtesy Ran Luo
College of Environmental Design alumnus Sben Korsh (M.S. Arch '16) was awarded the Emerging Curator Fellowship by the Canadian Centre for Architecture (CCA) in Montréal, Quebec. Korsh, who is currently pursuing his Master of Philosophy at the University of Hong Kong (HKU), will jointly hold the fellowship with his colleague at the University of Hong Kong, Maxime Decaudin, who is also a doctoral candidate at the Sorbonne University in Paris. Their appointment marks the first time the fellowship has been given to two people collaboratively.
Their project, titled "Natural Markets: Financial Architecture in the Capitalocene," will "examine contemporary landscaping of financial districts as a means to better understand the intersection between climate change and global finance." Over the course of the 2018-2019 year, Korsh and Decaudin plan to hold several residencies at the Canadian institution, and host a series of walking tours in both London's Canary Wharf and Hong Kong's Central District. "Entangled by histories of empire stretching from the early stages of industrial capitalism up to the present day, this project explores how seemingly mundane design features—like parks, plantings, and land works—reveal new frameworks to understand the inner workings of global financial markets and their wider planetary impact," Korsh and Decaudin write.
"The idea is to host a kind of 'live exhibition,'" Korsh explains, "with us as co-curators seeking to organise a conversation outside of the gallery and out in the streets. We'll feature objects about these financial districts that come from CCA's collection, and invite contributions from experts across architecture, finance, and environmental science."
"I became interested in financial spaces especially through writing my M.S. thesis at UC Berkeley, which looked at the corporate and urban history of the Transamerica Pyramid," Korsh says. "While popular architecture discourse tends to view skyscrapers as almost caricatures of capitalism, I found that there's actually a lot happening within these points in the skyline: They're essentially massive sites of elite corporate workspace, and looking at them historically can tell us a lot about how the city's economy functions and changes. I was staying in London during the summer I typed up that thesis, and found myself exploring Canary Wharf a lot, often just to people watch the huge number of financial workers."
"My collaborator Max, while a trained architect, has been working and teaching in HKU's landscape program for the past five years," Korsh says. "Since coming to HKU, [we] have been frequent interlocutors, and the project has come out of our overlapping interests of finance and landscape."
Korsh first visited Hong Kong with Berkeley's Global Urban Humanities' Art + Village + City research studio. He explains "I went a few days earlier to explore the city, especially the financial district, which I wrote a seminar paper on as an undergrad." Fast forward three years, and Korsh is now an M.Phil candidate at the University of Hong Kong, writing a thesis on the architectural history of the Hong Kong Stock Exchange, under the supervision of CED alumna Cecilia L. Chu (Ph.D. Architecture '12).


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2019 Mazda3 versus 2018 Mazda3
|2019 Mazda3 Sedan
|2018 Mazda3 Sedan
MPG (City/Highway)
|28/38 *
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|6-Speed Manual
2019 Mazda3 vs 2018 Mazda3
Serving Tuscaloosa, AL
Evaluating the soon to be released 2019 Mazda3 compared to it's popular 2018 predecessor is like trying to decide between your new favorite pair of jeans or the comfortable ones that have served you so well. There isn't a bad decision to be made. It just depends on what you are looking for. True, the 2019 Mazda 3 has retained much of what made its 2018 older brother a great choice. But, it has added some features and options that are sure to please both loyal Mazda customers and those who are open to a new driving experience. Or, as Mazda's new ad campaign puts it, are ready to "Feel Alive."
In 2018, Mazda offers two choices of SKYACTIVE®-G engines, 2.0 liter 155 hp 4 cylinder with 150 lb.-ft of torque, and a 2.5 liter with 184 hp and 185 lb.-ft of torque. The larger engine option in the 2018 is only available in the Touring and Grand Touring trim levels. For later in 2019, Mazda will offer a new powertrain with its new SKYACTIV®-X engine. Using compression ignition similar to diesel engines, this new setup offers gains in both fuel efficiency and torque. The supercharged 2.0-liter 4 cylinder boasts 190 hp (estimated) and 170 lb.-ft of torque. In conjunction with a mild-hybrid system, it is expected to enhance both performance and fuel efficiency. The 2.5 liter (SKYACTIV®-G) mentioned above will return, now as the base engine. A 1.8-liter Skyactiv-D is also an option. As before, the 2019 Mazda 3 offers the choice of 6 speed manual or automatic transmissions.
The Mazda3 has always been a hot little number, and the 2019 turns up the heat even more. As in 2018, you can select either sedan or hatchback designs, but now with a twist. In 2019, Mazda has incorporated its "Kodo design language", giving the sedan three more inches in length and a more elegant and sleeker look. For the hatchback, new body contours give it almost a mini-SUV style that sets it apart from the competition. Speaking of imitating SUVs, Mazda will offer i-Activ all-wheel drive on the 3 for the first time in 2019. Mazda's efficient AWD option features full-time front wheel drive until slippage is sensed, increasing fuel efficiency.
Interior & Safety Features
The 2018 Mazda3 earned high praise for its interior fit and finish, and infotainment system. In 2019 Mazda has taken its already significant advantage in this category to the next level. The clean simple design of the cockpit is fitted with an 8.8-inch color display that shows itself off just above the leather-wrapped dashboard. The updated MAZDA CONNECT ™ system with its patented controller is a new and improved version, even though the 2018 model was championed by reviewers as easy to use. The overall interior quality can compete with luxury cars costing much more.
As for safety, the 2018 Mazda3 achieved a 5-star NHTSA rating and was an IIHS Top Safety Pick. For 2019, added driver safety options available will include Mazda's i-ACTIVESENSE® suite. This will employ a brand-new Driver Monitor system. This new system is able to monitor the drivers' possible fatigue or drowsiness along with eye movements to assess whether they are distracted. Also included is a Cruising and Traffic Support feature providing assistance in the areas of braking, steering and accelerating during traffic jams.
If you are intrigued by the Mazda 3, there's much more to consider. Contact (or visit) the experts, your friends at Julio Jones Mazda. They look forward to hearing from you.
* Up to an EPA-estimated 28 city/37 highway MPG for 2018 Mazda3 4-Door Sport models with automatic transmission. Sport 4-Door models with manual transmission, 27 city/37 highway MPG. Actual results will vary.


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Jillian Michaels is Eating Her Words
Fans of The Biggest Loser have seen fitness trainer Jillian Michaels berate contestants about giving it their all. Her motto was, "If you're going to exercise, then you do it, and you do it 100 percent" but she has needed to change her attitude in the past year as she adjusts to being both a fitness professional and mother.
The fitness coach added two little blessings to her family within four days of each other in May of 2012. Michaels adopted a girl, named Lukensia from Haiti and her partner Heidi Rhoades delivered their son Phoenix. In a recent interview with Fitness magazine, she talks about how she has adjusted to being a parent while still maintaining her fitness schedule.
She says, "I get up at 7 a.m. — after being up all night with the baby — and run around trying to get both kids diaper-changed, dressed and fed. Finally I'll shower, and before I know it, I've got 50 emails to answer, and I need to leave for work. At the end of the day, I come home, and I'm like, 'Okay, let me bathe you, change you, feed you, read you books, put you to bed — wait, how am I supposed to do all this? Son of a b—-, this is hard!'" Michaels says she has resorted to answering emails while working out or waiting for Lukensia, who she calls "Lu" to put her clothes on by herself. While this whole motherhood thing has not worked out to be as simple as she thought, she gets through the day by remembering, "As long as I'm winning more than I'm losing, I'm still winning!"
I 100% get where she is coming from it is SO hard to take care of yourself when you are a parent. I cannot count the number of times I have started a fitness routine since having kids only to have it stop because I was exhausted or someone got sick and could not go to the gym daycare or a number of other reasons. I used to think I had to go to the gym to get in shape but have recently started some at home workout routines that have made staying on track so much easier. While I try to do it when my kids will not distract me, it does not always work out that way and that is ok. Besides what is cuter than turning around to see your 5-year old daughter trying to do a Brazilian dance move or attempt a downward dog at the same time as you?
Do you find time to work out as a parent?
Image via PR Photos


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The Stallions
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Each one more magnificent than the last... the Stallions...
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