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2015 Dalhousie Medical Education Institute
In conjunction with the 38th Annual Dr. Paul Cudmore Memorial Activities
About the Institute
In response to changing accreditation requirements and advances in assessment espoused by thought leaders in Medical Education, Dean Marrie convened the Assessment Unit Working Group (AUWG) in 2014 to advise on and ensure a high quality, sustainable assessment program spanning the medical school continuum .
To support faculty in this transition, the 2015 inaugural Medical Education Institute (which follows on the heels of the Cudmore lecture with Dr. Cees Van der Vleuten) will focus on current paradigms in assessment and the preliminary recommendations of the AUWG.
At the Institute you will learn:
- Characteristics and advantages of programmatic assessment
- Principles of effective assessment, applied to the evaluation of learners
- How to incorporate programmatic assessment into your learning context
The Institute is intended for:
- Clinical, basic, and health science faculty members
- Medical educators
- Health professionals
- Learners
As an accredited provider, Dalhousie University, CPD designates this continuing medical education activity for up to 5.75 credit hour for MAINPRO M-1 of the College of Family Physicians of Canada and as an accredited group learning Section 1 activity as defined by the Maintenance of Certification Program of the Royal College of Physicians and Surgeons of Canada. Through an agreement between the Royal College of Physicians and Surgeons of Canada and the American Medical Association, physicians may convert Royal College MOC credits to AMA PRA Category 1 Credits™. Information on the process to convert Royal College MOC credit to AMA credit can be found at www.ama-assn.org/go/internationalcme
Presenting Location
Theatre A, Sir Charles Tupper Medical Building (Link)
5850 College Street
Halifax, NS
Videoconference Locations
for the morning presentations only
|Dalhousie Medicine New Brunswick | Saint John, NB
|Rm. 218
|Dr. Everett Chalmers Regional Hospital | Fredericton, NB
|Rm. 208
|Moncton Hospital | Moncton, NB
|Rm. 1712
|Upper River Valley Hospital | Waterville, NB
|Rm. 14-020A
|Saint John Regional Hospital | Saint John, NB
|Rm. 1D South
|Colchester Regional Hospital | Truro, NS
|Rm. D1750
|Miramichi Regional Hospital | Miramichi, NB
|Rm. 3112
The Lord Nelson Hotel is offering a special rate for May 20 – 21. To make a reservation, call toll-free (1-800-565-2020) or locally (1-902-423-6331) and ask for the Education Institute rate/room block. Room are on hold until April 22.
On the agenda
|Welcome & Introductions
|Programmatic Assessment (PA): Reimagining Assessment at Dalhousie Medical School (Town Hall Discussion)
|Assessment Unit Working Group with
Dr. Cees van der Vleuten, Maastricht University
|Break (refreshments provided)
|Engaging Faculty in the Assessment of Learners
|Dr. Dale Dauphinee
|Using 360 Degree Assessment from School to Practice
|Dr. Joan Sargeant
|Break (lunch on your own)
|Concurrent Workshops Block 1
|How to Create Excellent Multiple-Choice Questions
|Dr. Keith Wilson
|Assessments in Competency-Based Education: Putting them Together & Coaching for Change
|Drs. Janice Chisholm &
Joan Sargeant
|Clinical Evaluation & the Failure to Fail
|Dr. Mary-Lynn Watson
|Concurrrent Workshops Block 2
|The Dalhousie Medicine Assessment Unit Working Group (AUWG) Recommendations: What do they mean for you?
|Assessment Unit Working Group
|How to Remediate for Issues of Professionalism
|Drs. Pam Forsythe & Michael Teehan
|Choosing Wisely: Collaboration, Communication and More
|Dr. Constance LeBlanc
|Reception (refreshments provided)
About the speakers
Click on the speakers for more information.
Dr. Cees van der Vleuten, MA, PhD | Professor, Dept. Educational Development and Research; Scientific Director, School of Health Professions Education, University of Maastricht
Cees van der Vleuten has been at the University of Maastricht in The Netherlands since 1982. In 1996, he was appointed Professor of Education and Chair (until 2014) of the Department of Educational Development and Research in the Faculty of Health, Medicine and Life Sciences and he has been the Scientific Director of the School of Health Professions Education since 2005. He mentors many researchers in medical education and has supervised more than 70 doctoral graduate students.
Dr. van der Vleuten has been published widely in his primary area of expertise, evaluation and assessment, and holds numerous academic and career awards. In 2005 he received the John P. Hubbard Award for a significant contribution to research and development of assessment of medical competence from the National Board of Medical Examiners in the US. In 2010, he received a Dutch royal decoration for the societal impact of his work and in 2012 the Karolinska Prize for Research in Medical Education.
He frequently serves as a consultant and holds honorary academic appointments in the Department of Surgery and Internal Medicine, University of Copenhagen in Denmark, Department of General Practice, Radboud University Nijmegen in The Netherlands, Northumbria University, Newcastle upon Tyne, in the United Kingdom, School of Medicine, Flinders University, Adelaide in Australia, University of the Witwatersrand, Johannesburg in South-Africa and Curtin University, 2014-2015, Perth in Australia.
Dr. Dale Dauphinee, MD | Adjunct Professor, Division of Clinical Epidemiology, Faculty of Medicine, McGill University; Senior Scholar, Foundation for Advancement of International Medical Education & Research; Senior Advisor, World Federation for Medical Education
Dr. Dale Dauphinee, former Chair and Professor in the Department of Medicine at McGill University, also served as the founding Director of the Division of Clinical Epidemiology at the Royal Victoria Hospital, the Associate Dean of Medicine (Medical Education), and the Director of the McGill Center for Medical Education Research.
From 1993-2006 he was the Executive Director of the Medical Council of Canada where he established its first in-house research program, an external research grants program, directed their pioneering move to adaptive on-line assessment methods, and created the national physician identifier and physician credential verification services. During that time, he was a Trustee of the American Board of Internal Medicine and received many awards for distinguished service, including the John Hubbard Award from the National Board of Medical Examiners for excellence in contributions to medical assessment and evaluation, an Honorary Membership in the College of Family Physicians of Canada, and a Fellow of the Canadian Academy of Health Sciences.
He currently sits on several editorial and international advisory boards and continues to conduct research into workforce production, developing informatics infrastructure and assessment outcomes strategies, as well as consulting and advising universities, national professional bodies, governments, and health sciences educational programs internationally.
Dr. Joan Sargeant, PhD | Professor & Head, Division of Medical Education; Education Researcher, Continuing Professional Development, Dalhousie University
Joan Sargeant is a Professor and Head, Division of Medical Education, Dalhousie University. She is an educator and researcher in medical education, with a particular interest in the assessment of learners and practitioners. Her current research explores how to facilitate feedback to learners in a way that will increase its acceptance and usefulness.
Dr. Keith Wilson, BA, MD, PhD, CCFP | Assistant Professor, Dept. Family Medicine, Dalhousie University
Dr. Keith Wilson is an Assistant Professor in the Department of Family Medicine and teaches at both the undergraduate (at DMNB) and postgraduate levels at Dalhousie. He has a keen interest in the assessment of learners in medical education and has had a number of opportunities to learn from experts in assessment worldwide. Dr. Wilson is currently applying his knowledge in the undergraduate Professional Competencies course to enhance assessment for and of learning.
Dr. Janice Chisholm, BSc, MD, FRCPC | Associate Professor, Dept. Anesthesia & Critical Care & Program Director - Postgraduate, Dalhousie University
Dr. Janice Chisholm is an Associate Professor and the Residency Director in the Department of Anesthesia, and Chair of the Critical Care Simulation Program at Dalhousie. She is also a staff anesthesiologist at the QEII Health Sciences Centre.
Dr. Chisholm has earned a number of teaching awards including: Anesthesia Undergraduate Teacher of the Year (2007), Critical Care Educator of the Year (2007 & 2010), Clinical Teaching Recognition Award (2006 - 2007), and Resident Mentor of the Year (2013). Her love of teaching extends beyond Dalhousie and the QEII, having participated in a teaching mission to Rwanda in 2009, 2011, and 2013.
Dr. Mary-Lynn Watson, MD, CCFP(EM) | Associate Professor, Dept. Emergency Medicine, Dalhousie University
Dr. Watson is an active staff member of the Emergency Department at the Queen Elizabeth II Health Sciences Center in Halifax and an Associate Professor of Emergency Medicine. She holds a cross appointment in Family Medicine and Continuing Medical Education at Dalhousie University. She is also a member and former Chair of the Progress and Promotion Committee at Dalhousie University Medical School.
Dr. Watson is the former Residency Director for the CFPC(EM) program at Dalhousie University and former President of the Canadian Association of Emergency Physicians.
Dr. Pam Forsythe, MD, FRCPC, DFCPA | Assistant Professor, Dept. Psychiatry, Dalhousie University; Assistant Professor, Dept. Psychiatry, Memorial University; Director of Student Affairs, Dalhousie Medicine New Brunswick
Throughout her rather eclectic career as a general psychiatrist, medical administrator, and educator, Dr. Forsythe has seen the best and worst of professionalism behaviors. As the Chair of the Professionalism Committee for the Faculty of Medicine at Dalhousie, she is keenly aware of the complexities of teaching and modeling professionalism excellence, and remediating professionalism lapses within medicine. As a psychiatrist, she has had a longstanding interest in physician health matters and through the Student Affairs portfolio she sees opportunities to encourage the next generation to be both committed and resilient.
Dr. Michael D. Teehan, MD, FRCPC | Associate Professor, Dept. Psychiatry & Assistant Dean, Student Affairs, Faculty of Medicine, Dalhousie University
Dr. Teehan completed his specialty training at Dalhousie, and joined the faculty in 1985 upon graduation. He has served in senior leadership roles, including Residency Training Director, from 1994 - 1999.
In 2010, he was appointed to the newly created post of Assistant Dean for Student Affairs. In that capacity, he has dealt with issues of professionalism in medical students, and the consequences for breaches of professional behaviour.
Dr. Constance LeBlanc, MD, CCFP(EM), FCFP, MEd | Associate Dean, Continuing Professional Development & Professor, Dept. Emergency Medicine, Dalhousie University
Dr. LeBlanc has had the privilege of providing clinical care in the Emergency Department at the QEII for over 26 years. Throughout this time, she has also assumed academic responsibilities as Director for Undergraduate Medical Education in Emergency Medicine, Director of Postgraduate Medical Education in Emergency Medicine, Program Director for the CCFP(EM) Medicine program at Dalhousie, and currently as Associate Dean of Continuing Professional Development (CPD).
During the eight years she was Chair of Continuing Medical Education for the Canadian Association of Emergency Physicians (CAEP), Dr. LeBlanc developed the Risky Business Roadshow [funded by, and in collaboration with, the Canadian Medical Protective Association (CMPA)], the Musculoskeletal Injuries in Adults & Children Roadshow (funded by CAEP), and the Infectious Disease Roadshow (funded by CAEP). She was also a developer and speaker for the first iteration of the ED STAT Roadshow and is currently a speaker in the CAEP Review Series.
Currently she serves as the CAEP representative for the International Federation of Emergency Medicine representing Canada on both the Education and CPD Committees, and sits on the CAEP Academic Emergency Medicine Committee.


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|Kenji Mitsuura
|Character Info
|Mitsuura Kenji
|Voice Actor(s)
| Shinya Fukumatsu
Chris Cason[1]
|Professional Status
|Awakening Lab
|Chapter 20
|Episode 6
|Image Gallery
Kenji Mitsuura (密裏賢治, Mitsuura Kenji) is the founder of the Awakening Lab.
Kenji is a tall young man who has light brown hair, a goatee, light brown eyebrows, short sideburns, and small eyes with black pupils. His hair is styled into a small afro.
Kenji wears a pair of white penny loafers; orange socks; red trousers; a black belt with a silver buckle; a one-button blazer jacket with a light beige collar and a checkered red-white pattern; and a dark red shirt with several images of open eyes on the front.
Kenji is friendly and sociable, a nice guy all around, though he is a bit eccentric. Despite his vast wealth, he is not interested in money or its many perks - his goal in life is to become an esper, and has been pooling all of his resources into psychic research so he can make his dream come true. He is very optimistic and determined to rise to his own standards, which is sympathized by Ritsu, who had similar desires.
He has a cordial relationship with the esper children of the Awakening Lab, and is rather disturbed when Ritsu's questions for them imply he was doing illegal experiments on the children. After the esper children were kidnapped by Claw, Kenji became very distraught at his inability to protect them.
Kenji hailed from a local wealthy family. At one point, he used his family's money to create the Awakening Lab for the purpose of researching psychic abilities so he can find out how to awaken them in normal people such as himself. Along the way, he recruited Takeshi Hoshino, Go Asahi, Rei Kurosaki, and the twin brothers Daichi and Kaito Shiratori. These children were revealed to be espers, and have been staying with him to develop their budding powers.
Big Cleanup Arc
Shortly after Mob's psychic fight with Teruki Hanazawa occurred, Kenji met Ritsu Kageyama, mistaking him for his older brother, and gave him a business card that contained the location of the Awakening Lab. Ritsu, who had been resenting Mob for possessing the psychic powers he wants, decided to check out the place.
After Ritsu arrived at the Awakening Lab, Kenji gave him a tour and introduced him to the esper children learning there. All of the children displayed very weak abilities, which failed to impress Ritsu. Ritsu later asked the children if Kenji did anything to them to make their powers awaken, which Kenji was disturbed by. Takeshi assured Ritsu that Kenji is just interested in psychic powers. Kenji reveals that his dream is to become an esper, and created the Awakening Lab to make it happen. Ritsu thought it to be a foolish dream, but sympathizes with the man's desire to rise to his own standards.
Later, as Ritsu attempts to bend a spoon in a psychic development room, Kenji notices Ritsu's darkening mood, unaware of the boy's growing feelings of guilt. Ritsu finally reveals to Kenji that he's just a normal human unlike his powerful psychic brother Mob, and throws away the spoon in frustration before storming out. While an amused Takeshi expressed doubts over Ritsu actually having psychic potential, Kenji finds Ritsu's discarded spoon and is surprised to see it severely twisted out of shape.
After Ritsu is possessed by Dimple, he displays his increased psychic powers to a shocked Takeshi and Kenji by bending many spoons at once. Ritsu then offers to do more by snapping Kenji's car in two. Kenji is disturbed to see Ritsu's personality take a malicious turn.
7th Branch Arc
During Claw's attack on the Awakening Lab, Kenji along with the neuro scientists he hired for the research facility were knocked unconscious, while Takeshi, Rei, Go, Daichi and Kaito were bound and kidnapped by Sakurai. He was later revived by Mob and Teruki, who suspected him for having ties to Claw. Kenji's distraught feelings towards the kidnapped esper children revealed that he actually didn't know Claw. During a discussion over how to take on Claw, Kenji suggests letting him go with Mob and Teruki, but is turned down.
Suddenly the trio are confronted by Terada, who seeks to kill Mob so his power won't surpass his if he joins Claw. Using their psychic powers, both Mob and Teruki easily subdued Terada and his henchmen and interrogate him for information. Despite Terada giving all that he could, Teruki doesn't believe he would be so willing to expose his Claw employers.
While Mob and Teruki go off to rescue the esper children and Ritsu (who was kidnapped by Koyama), Kenji was left behind due to being a normal human.
He reveals that Teruki has joined the Awakening Lab.
World Domination Arc
Kenji allows Reigen to use the Awakening Lab as a place to gather for those who plan on fighting against Claw. He stays there with Reigen while all the espers go out to put a stop to the chaos, but the lab is soon found and breached by Claw soldiers. In an omake he is shown to have hid inside a cupboard while Reigen hid in a broom closet with Dimple and the unconscious Mob, and appears to have stayed there for the battle which ensued when Shibata arrived.
???% Arc
He is seen watching ???% destroying the city on his phone, wondering if it is a natural disaster.
Powers & Abilities
Other than his great wealth, Kenji does not possess any psychic abilities.
- "I'm the son of a wealthy family, but I'm not special. I don't believe in doing anything to make advancement in society or science. I just want to become an esper."[2]
- ↑ https://twitter.com/Casonworld/status/821465219180306432
- ↑ Mob Psycho 100 Manga and Anime — Vol. 3 Chapter 22 (page 27-29) and Episode 6. Kenji explaining his desire to Ritsu Kageyama.

subset: commoncrawl


text: CRAIGIE AITCHISON Craigie Aitchison A truly great colourist, Craigie Aitchison's skill translated so well into silkscreen printmaking. Click on the Gallery image to find out more. BIOGRAPHY Craigie Aitchison Craigie Aitchison (1926-2009) was a Scottish painter best known for his rich, colour-stained canvases. His work displays a fascination for crucifixion scenes, small dogs and horses, and still lifes, all set within sparse, luminous landscapes that have an overall transparent glow. Similar to painters as varied as Piero Della Francesca, Milton Avery and William Blake Aitchison's paintings have a mystical quality. Born on January 13, 1926 in Edinburgh, United Kingdom, he studied law at Edinburgh University before attending the Slade School of Fine Art in London. Like Henri Matisse, Aitchison preferred painting to law and possessed an innate understanding of colour and the objects around him. The artist became an Associate of the Royal Academy in 1978 and had several retrospectives of his work exhibited during his lifetime at the Serpentine Gallery in London, Harewood House in Leeds, and the Gallery of Modern Art in Glasgow, among others. The artist died on December 21, 2009 in London, United Kingdom. His works are in the collections of the National Galleries of Scotland, the Tate Gallery in London, and the National Museum Wales in Cardiff, among others. GALLERY Lemon and Birds 2002 MORE DETAILS


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Plywood QC Inspection Checklist : Part 12 things you may not know about CORE structure Types and Quality,
When inspect the plywood ,accordingto the buyers's request ,normally should check the core structure types first ,because the Plywood core structure type plays an important role in the final applications of the plywood .
But this is not a simple work to distinguish the inside plywood core structure . Sometimes, due to the closure or treatment of the plywood edge , it is difficult to distinguish the inner core structure from the edge of the plywood. This requires the QC to use their professional experience and skills to distinguish.
Now, according to some of my personal quality inspection and production experience, do some simple introduction, hoping to provide some help to buyers or consumers.
1.Traditional Fresh veneer core structure
Why I use the two words of Traditional ,and Fresh ?
First ,traditional means always from the beginning of the plywood industry manufacturing ,always use veneer .Why I used the fresh here ,because fresh veneer is from the logs directly ,actually the fresh veneer is like virgin or Male virgin, the first time used for plywood manufacturing .
7 years ago ,when I inspected some film faced plywood in linyi ,I have one principle that before any finished plywood inspection ,I must check their whole production line .So I requested the factory's boss to show me their production line and how they made the plywood .But the boss refused to show me and explained too much that their platform were produced in their new factory ,and the factory is very far away from the hot pressing factory .So I gave up then .
But when I inspected the plywood,I always try to check the long span loading capacity of the plywood ,I found the structure of the film faced plywood was notgood ,then requested the factory to cut the whole piece and show me why .After they cut the plywood,I found the plywood core I HAVE never seen such core ,like lumber blockboard core .Finally they explained to me this is a new type of plywood core to make plywood,they called it The second generation core plywood ,now we called them recycled joint core blockboard .
FYI :Tilt the plywood 45 degrees, then stand on the board and jump to test whether the structure of the board is reasonable, load-bearing performance and so on. If it is a plywood of furniture grade, a person of 50 to 60 kilograms usually jumps on the board for a few times. If there is no clicking sound coming from the inside of the board, the structure of the board can be simply judged to be very good. If there is a click sound inside the board, it indicates that the structure of the board or the materials used are not qualified. If it's a film faced plywood or construction grade plywood, it takes 60 to 80 kilograms of people to jump on the board, usually tilting the board 40 degrees.
2.Recycled joint core
The recycled joint core ,also called The second generation core ,like prostitute or Dancing male ,used many times .These second generation core are recycled from the construction sites or other applications .Cut these recycled plywood to long strips or small piece of blocks ,then glued together to make the platform for low quality film faced plywood production .
The quality is low ,but cheapest core .
Now ,we even saw some manufacturers using this kind of recycled core to make furniture for exporting ,even for domestic , It's a retrogression of history. Because of the loading capacity is weak ,formaldehyde emission rate is too high .It is very dangerous .
But one most important factory affect the final plywood quality ,the recycled core film faced plywood have a very good and better improved surface ,flat and smoothness .just like two times hot pressing ,or sometimes three times hot pressing film faced plywood .
Advantage : Flat and smoothness
Disadvantage : weak ,and high formaldehyde emission
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Ashley Manor
- 3660 Main Street, Barnstable, MA, 02630
- (508) 362-8044
DetailsAshley Manor, a charming romantic Inn, is located in the heart of Cape Cod's historic district, minutes from Barnstable Village and Barnstable Harbor. The Inn is surrounded by two acres of park like grounds and tennis court. Six beautifully appointed guest rooms, including four luxury suites offering wood-burning fireplaces, full private bath and separate two-person Jacuzzi tub. A full gourmet breakfast is served outdoors in the warm weather on the patio overlooking the garden and tennis court. In cooler months, enjoy your breakfast in front of a roaring fire in the formal dining room.


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Fintech is booming around the world and Victoria is proving to be extremely fertile ground for innovation.
Fintech is the revolution which is sweeping the financial world. A new generation of innovative companies is offering new ways for consumers to engage with the financial world. Whether it's making overseas transactions safely and affordably, raising funds or playing the stock market, this entrepreneurial sector is changing the game – and many of the most exciting companies are to be found right here in Australia.
A recent Frost & Sullivan report predicts the Australian fintech sector to grow at a staggering compound annual growth rate (CAGR) of 76.36 per cent, reaching A$4.2 billion by 2020. Demand is being pushed by a wealthy demographic between the 13 to 34-year-old age bracket that is cash-rich and looking for new services the banks currently do not, or cannot, offer.
Several global fintech players have expressed a keen interest in Australia's fintech landscape, seeing the market as ripe for expansion. Acorns, the US company which allows its customers to invest spare change, says it targeted Australia as the next stage for expansion, thanks to its deep mobile penetration and tech-savvy population.
The startup boom
However, it's the domestic Australian fintech startup scene which is causing a stir. Currently, FinTech Australia estimates there are 250 of these companies in Australia, with Victoria and New South Wales proving particularly attractive. This number is growing and fintech businesses are extremely bullish about the future.
The EY FinTech Australia Census 2016 report revealed that 82 per cent expect to see their revenue grow over the next 12 months, with 72 per cent taking on more employees and 38 per cent planning to expand overseas.
Victoria is working hard to become a major fintech hub. Last year, LaunchVic injected A$300 million into FinTech Australia as it geared up for the inaugural FinTech Summit. It's all part of a wider strategy, which the government hopes will make Victoria a major player in the boom. The aim is to become a location of choice for startups across the Asia Pacific region and help young companies turn good ideas into thriving enterprises.
The government has also run meetups in which a selection of the most viable startups from across the state got the chance to meet a collection of heavyweight US investors. They have good reason to be enthusiastic. The Frost & Sullivan report on the state of the fintech sector suggests A$1 billion of the A$4.2 billion market will be a new value for the economy.
It's a market of rapid growth and innovation with enormous potential for expansion. It's offered up faster, more affordable ways to transfer money overseas, delivered a range of financial management services for individuals and businesses and seen the growth of new sectors such as crowdfunding. These opportunities have not only offered new ways for investors and savers to make money, but also open up new sources of capital for small and businesses, which might previously have been ill served by the banks.
Filling gaps
Indeed, for many people, a sense of disruption and innovation is key to the sector, one which addresses gaps left by conventional methods of finance and challenges the existing order. Certainly, many of the exciting companies exhibiting at the FinTech Australia Summit 2016 exist because they are filling hole—something conventional financial institutions have not covered, as Aris Allegos of small business finance provider Moula Money acknowledges.
"The opportunity has arisen because the big four are predominantly balance sheet and secured lenders," Aris Allegos says. "By virtue of being a secured lender, it's a very different investment decision to the assessment we make. That's not to say the banks aren't servicing the small business segment, but there is a large part of the small business sector which is left untouched by virtue of the fact that small businesses don't all have security or cash to put on deposit."
Victorian company Timelio is another example that is plugging a gap the major banks often overlook. Their niche is invoice financing, which enables small businesses to get paid on time rather than waiting 30 to 90 days.
"This is a niche product that is not understood… and thereby, those customers are not serviced," Charlotte Petris, Founder and CEO of Timelio, says. "Two of the Big Four banks pulled out of this market after 2008, so there is a large gap there."
Other startups offer exciting new ways for people to get involved with finance. FirstStep works to change the way we invest by allowing you to invest with your loose change. Any purchase you make is rounded up to the next dollar and the spare cash pumped into an investment fund. For example, if you buy a coffee for $3.80 it would invest the space 20 cents into the fund. Over time this would build up without thinking about it. Their aim is to allow small change to turn you into a millionaire.
The old and the new
However, this is not just about doing things the banks can't. Almost half of respondents to FinTech Australia's survey said that collaborating with existing players was a key part of their forward strategy. Westpac, one of Australia's oldest institutions, organised an event in 2016, in which a group of young entrepreneurs pitched their ideas at a "Shark Tank" styled event. National Australia Bank (NAB) has recently launched a A$50 million innovation fund which is turning its attention to fintech startups.
This is, then, a market which is open for new players and attractive to larger existing funds. It's one in startups can potentially trigger rapid growth in and become big names in their own right. Victoria, with its tech-savvy population, fertile entrepreneurial scene and support from the government, represents an ideal location for this transformative market of the future.


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- By Amy Herzog
- Directed by Lila Neugebauer
Emma Joseph is young, ambitious, talented, and about to put the ideals of her politically leftist, New York family into action. But a long-buried secret about her much-loved blacklisted grandfather threatens her work and throws her principles—and loyalties—into question. As the family, including grandmother Vera, wrestle with their legacy, Emma must chart her own course forward.
The Amy Herzog Festival: 4000 Miles and After the Revolution
Center Stage introduces Baltimore to playwright Amy Herzog, one of the most exciting voices in American theater, through two of her hit plays—staged in repertory for the first time ever. Featuring three generations of one New York family, After the Revolution and 4000 Miles are gripping and surprising examinations of the unending power of family to shape our identities and our lives.
Learn More
Creative Team
Set Designer
Costume Designer
Lighting Designer
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Casting Director
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In the Press
For all other press related information please go to our Press Room or contact:
Robyn Murphy at 410.986.4016 or email@example.com.
In the News
- 03.21.15
- The Baltimore Sun—Amy Herzog blends family history in two acclaimed plays
- 03.18.15
- The Baltimore Sun—Ashton Heyl on the emotional impact of Center Stage's 'After the Revolution'
- 02.24.15
- Baltimore STYLE—Amy Herzog examines her politically charged family history without apology...
- 03.24.15
- City Paper—'After the Revolution' and '4000 Miles,' two plays at Center Stage, focus on a family...


text: Help Delhi Maintain its Hygiene! by Bikram K. Singh | SOCIETYIt was November morning and wintery (just on paper like everything else in India). The day was not as cold as it had to be. Regardless, I rode toward Gurgaon, feeling empowered, on my 350cc beast. The sweet sound of engine and the rustling of air through my helmet are...Read Full Article


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Barr started shipping its "morning after" birth-control pill to US pharmacies to begin over-the-counter (OTC) sales for the first time.
Barr Pharmaceuticals Inc. won US regulatory approval on August 24 to sell the drug without a doctor's prescription to women ages 18 and older. The drug, called Plan B, will be available in pharmacies across the country by mid-November, the Woodcliff Lake, New Jersey-based company said yesterday in a statement. Plan B, which is designed to prevent pregnancy when taken within 72 hours after sex, was cleared in 1999 for US sales with a prescription. Barr's application to sell the pills over the counter ignited a three-year political debate between people who wanted more timely access to the drug and those who argued that it might promote sexual promiscuity among teenagers.
"Patient demand is going to warrant that it is going to be stocked by lots of retail outlets," Will Sawyer, an analyst at Leerink Swann & Co. in New York, said yesterday in a telephone interview. OTC availability may help Barr triple annual sales of Plan B to as much as $90 million within three to four years, Sawyer said. Barr's CEO, Bruce Downey, said in August that Plan B made about $30 million last year, or about 3% of the company's sales. Shares of Barr rose $1.47, or 3%, to $51.36 at 4 p.m. on Monday in New York Stock Exchange composite trading. The stock has dropped 18% this year.
The US Food and Drug Administration granted Barr three years of exclusivity to sell the OTC pills without generic competition until August 2009, the company said yesterday. Women ages 17 and younger will still need a prescription. Sawyer said Barr's timing of the OTC shipments and its marketing plans have met analysts' projections so far. Pharmacies will pay about $27.95 per treatment when the pills are purchased wholesale, Barr spokeswoman Carol Cox said yesterday in an e-mail. Prescription-only versions of the drug were less expensive to make and were sold to pharmacies for $18.89 per treatment, she said.
The price that consumers pay will vary depending on what stores charge. Barr buys Plan B as a finished product from Budapest-based Gedeon Richter Nyrt, Eastern Europe's biggest maker of gynecological drugs. Cox declined to comment about how the two companies split profit from the drug. Richter shares rose Ft 1,095, or 2.6%, to 42,595 forint in Budapest. About 250 Barr sales representatives who had been responsible for marketing the prescription pills will promote Plan B to doctors and pharmacists as an over-the-counter drug as well, the company said.
Barr has also started an information campaign for consumers and health-care providers about the drug and the federal age restrictions. Barr derives about two-thirds of its revenue from selling cheaper copies of brand-name medications. The company bought Croatian drugmaker Pliva d.d. last month to become the second-largest US maker of generic drugs. Corona, California-based Watson Pharmaceuticals Inc., which completed its acquisition of Andrx Corp. on Sunday, ranks first by 2005 revenue. (Bloomberg)


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Our PolyLevel® Dealers Serving Kansas
Papillion, NE 68046
Thrasher was founded in 1975 by Greg Thrasher. Today, they are one of the largest foundation repair contractors in Nebraska, Kansas, Western Iowa and Northwestern Missouri.
Conditions where outdoor concrete has already begun to sink is not uncommon in Kansas and is often the result of shifting or a weak soil base or erosion. It causes driveways, sidewalks, walkways, concrete steps or patio areas to become tripping hazards and can effect property value.
Kansas, also known as The Sunflower State, hosts a variety of soil types, ranging in density and load-bearing capacities. The topography ranges from flat in the west to hills and forests to the east.
Soil in any environment can change, however. When the weight above the soil exceeds the soil below, the soil will compact and settle. Clay and silt can also cause soil to compact when it becomes dry. Regardless of the reason, once soil becomes compact, heavy concrete above the soil will sink and crack. It's a gravity thing!
While it is a very noticeable problem, with the right contractor, it can have a very simple solution.
Previously, sinking concrete was repaired by a technique called "mud jacking" that uses a thick slurry to fill in the gap underneath the sunken concrete. While effective, it is not the most efficient way to solve the problem, and adds more weight above the compacting soil.
Today, select contractors in Kansas are trained and to provide a better alternative to mud jacking. PolyLevel is a less intrusive, lighter weight solution that doesn't add more weight to the problem.
If you are seeing signs of sinking concrete on your property, have a contractor to provide the PolyLevel alternative to mud jacking take a look at it. The following Kansas contractors are trained and to provide a free estimate to solve your sinking concrete problem.
Recent job requests for PolyLevel in KS:
Project Location: W 70th St, Prairie Village, KS 66208
Comment: I have a section of my patio and driveway that need to be raised and leveled
Project Location: W 194th St, Stilwell, KS 66085
Comment: Sinking driveway pad near garage
Project Location: West Locust, Troy, KS 66087
Comment: I have a building approach into a building needing a quote of lifting it up
Project Location: Baldwin City, Baldwin City, KS 66006
Comment: Driveway needs leveled, it is sloping towards the house, causing water to run towards foundation
Project Location: Holly Lane, Junction City, KS 66441
Comment: Looking for estimate for polylevel. Driveway has sunk along with soil from water gutter which drained under the driveway.
Project Location: 6TH ST, Wakefield, KS 67487
Comment: I have a driveway that is sinking and cracking. About 12yr old drive.
Project Location: Lulu, Augusta, KS 67010


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Intensifiers in English
Intensifiers are adverbs which are used with gradable adjectives, adverbs and some verbs. They normally strengthen the meaning.
Your presentation is good.
Your presentation is very good. (the meaning is strengthened by the intensifier: very)
Your presentation is quite good. (the meaning is weakened by the adverb of degree: quite)
ExercisesGrammar exercises - Adverbs
- Grammar explanations
- Grammar exercises
- Vocabulary
- Idioms
- Phrasal verbs
- Prepositions
- Opposites
- Synonyms
- British vs. American
- English proverbs
- Word formation
- English abbreviations
- Download


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Duchinni Quest Adventure Boot Black
Availability: In Stock£129.99
Ex Tax: £108.33
As the South West's Weise stockist we are able to supply any item from the Weise range and if you cant see what you require please get in touch and we will always get it in for you at the best prices
For non-stock items, we have two deliveries per week from Weise so if they have it in stock we can normally get it in a few days, any enquiries please call us at 01392-467700 or email Roland: firstname.lastname@example.com
Kick it up a notch with the Duchinni Quest adventure boot which is new for 2018! A sporty boot with full-grain leather for touring and performance and it is breathable and waterproof.
Full grain leather upper
Waterproof and breathable internal liner
Oil resistant non-slip rubber sole
Shin, tow, heel cup and shift zone reinforcement
Adjustment of the ankle with buckles
Reflective heel panel.
Write a reviewYour Name:
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text: Dosa, the one true South Indian dish made with various toppings, just cannot go wrong. If you're tired of always cooking Dosas the traditional way, here's a healthy Spring Dosa Recipe that will change the way you make Dosas forever. Looking forward to learning how to make Spring Dosa? Follow this recipe that we've put together for you.


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Grow Your Gift Conservatory of Music
939 Beal Pkwy NW
Fort Walton Beach, FL 32547
(850) 483-0800
Fort Walton Beach's newest community music institution dedicated to performance education. We offer private lessons on many instruments, voice, and sound engineering. Throughout the year we offer group lessons, summer camps, master classes, and clinics!


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The Mission
Develop 150 apartments within College Town in Rochester, NY, a mixed-use project located at the entrance to the University of Rochester and immediately adjacent to the University of Rochester Medical Center (URMC).
The Solution
College Town Rochester is an exciting close-knit district providing the neighboring community, University of Rochester and URMC students, faculty and staff a one-of-a-kind, vibrant place to live, learn, dine, shop, work and play. Mount Hope Lofts, located directly above retail and dining at College Town, offers a variety of stylishly designed Studio, 1 and 2 bedroom apartments.
The Details
Apartment amenities include Silestone Blanco Norte Quartz counters, large walk-in closets, stainless steel GE appliances, washer/ dryer in each unit, wood finished flooring & plush carpeting, glass tile backsplashes, Moen pull out faucets and central air conditioning. Community amenities feature state-of-the-art fitness center and on-site management.


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THIS IS A FICTIONAL STORY set in "Atlantic Republic" setting, which is jointly developed in Russian-speaking Livejournal community "Atlantic Republic - A Dieselpunk Legend". All circumstances and events here are fictional, although many of them are based on real events which happened in our world. Also many people and organizations mentioned here were (or still are, in one case) real, although their…Continue
Added by Ignat Solovey on November 8, 2012 at 12:30am — No Comments
© 2020 Created by Tome Wilson. Powered by


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Condo Corner
Welcome to Condo Corner. A list of great condo buildings in Toronto with full Walk Score functionality so you can see what's in the surrounding community.
Select Condo:
Adelaide Square
330 Adelaide Street East
St. Lawrence Condos & Lofts – Adelaide Square – Toronto
Purchasers of suites in this extremely affordable fashion district building have the Midas Touch. 88 units and 6 townhomes offer exceptional value and location, with easy access to Queen and King Streets, a myriad of interesting stores, and the TTC. The suites range in size from 550 sq ft to 1100 sq ft. and all have balconies and storage lockers. With secure underground parking, a gym, a party room and concierge, these amenities make up for the 9-storey buildings lack of architectural grandeur.


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Learn the power of positive thoughts and your life will change for the better.
Think positively and positive things will happen to you.
This is the Law of Attraction in its simplest form.
Humans love negativity. We are pre-disposed to it. We engage and pay more attention to sadness, anger, disappointment, and pain than we do joy, happiness and contentment. We seem to regard these happy things as things we do when we need to celebrate something specific rather than live our lives in joy, in happiness and contentment.
We spend too little time appreciating our happiness and even though these positive thoughts are so much nicer, our negativity is addictive.
Ironically as I am writing this post it is 21 January. Deemed to be 'Blue Monday' as it is claimed to be the most depressing day of the year. The day most people are likely to give up on their new year's resolutions, the day when credit card bills start coming through the letterbox, cold, dark nights and post – Christmas blues.
How have you been feeling today?
Decide for yourself, that today will be the start of you being happy!
Give thanks and appreciate all that you do have in your life rather than complaining or stressing about what you don't have.
When you look for something good in another person's words and actions, you will almost always find something as most people are trying to do the best they know how. Resolve to be cheerful every day, no matter what happens and challenge yourself to look for good in every person you meet on a daily basis.
Thinking positive thoughts doesn't leave any room in your mind (both consciously and sub-consciously) to entertain any negativity or doubt. Once you have learnt positive thinking, you will feel lighter and happier. Your brain will be excreting those feel-good hormones called endorphins. You will also notice an increase in your self-confidence, and it will also have a positive outcome on your health and your whole life.
But this positivity has to be practiced until it becomes second nature, remember earlier I said that we are pre-disposed to negativity?
You have to believe you can change your thinking and reaffirm these new thoughts to yourself daily, weekly until it becomes an unbreakable habit. When you have reached the point of complete belief in you positive thinking, you will get a rush of positive energy throughout your body. Remember this rush and use it as a gauge as to whether or not you are in true belief and positivity at any moment in time, each and every day.
Remember the quote from Henry Ford?
"If you think you can do a thing or think you can't do a thing, you're right."
Chose to 'do the thing' and learn the power of positive thoughts.
I would appreciate your comments. If you would like to learn more about my work, then please get in touch.


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What is the length of the parachute
section in inches ?
How many PSI of pressure do you
need ?
This calculator is meant to
give you an idea of how much BP to use in your ground tests. You should
always start ground testing with the smallest amount that you feel might work.
Also, note that PML "Piston Ejection Systems" require even less pressure than
traditional systems. To calculate how much PSI your rocket requires, see
You need Grams of FFFFG Black Powder
10 to 15 PSI is a good range for safe parachute ejection for a 4 inch
diameter rocket.
How much PSI will my rocket need ?
What is the diameter of the
parachute section in inches ?
Use between
PSI for a lose
fitting parachute
PSI for a
tighter fitting parachute in my calculator above.
For more information about PSI recommendations and to see what my PSI
calculations are based
read this article
at Rocketry online.
Email me your


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GAS and OIL does not pay! You got:
Hello Edvard Napoleon.
$165.00 has been successfully sent to your LibertyReserve account n/a.
Transaction batch is n/a.
gas-and oil me estafaron ellos yo tenia un retiro pendiente y segun ellos mandaron el dinero a mi LR pero nunca aparesio en mi balance
By this time we have no reasons to think that Gas and Oil program doesn't pay. Reportedly the payments are made properly day-to-day. We will apply to the project administration for the clarifications. In case the situation won't be clarified please contact us once more. We'll try to help.


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Anniversaries are sometimes difficult to forget, eleven days ago (May 18th ), outside the Crimea's capital, Simferopol, 10,000 people participated in a rally, carrying placards calling for "self-determination" and commemorated the 70th anniversary of Stalin's 1944 deportation of the Crimean Tartars. Many of the 200,000 deportees suffered and perhaps 25% died - some during deportation and others in exile. The Mejlis, the Crimean Tatars' main representative body, has adopted a resolution calling for "territorial autonomy" for the community, Tatar representatives in the Crimean government, and "an end to discrimination against and the repression of the Tatars of Crimea."
There was a heavy police presence in Simferopol, and military helicopters flying low over the rally. Earlier dozens of people gathered at a memorial near Simferopol's railway station, the deportation point for thousands of Tatars sent into internal exile. President Putin (who is admired by Nigel Farage) met with Crimean Tartar representatives in Sochi (on May 17th) and stated that Russia would improve the lives of Crimean Tartars. Simultaneously several hundred people also marched in support and remember the deportations in Ukraine's capital, Kyiv. Incidentally the rally had been banned by the pro Moscow Crimean authorities.


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I Can Reach You (From One to Many)
October 3, 2015 – February 28, 2016
OPENING: Saturday, October 3, 2015, 4-7:30pm
Artists: Bianco-Valente, Claudia Losi, Valerio Rocco Orlando
Curated by: Daria Filardo, Pietro Gaglianò, Angel Moya Garcia
I can reach you (from one to many) is a project that reflects on the idea of 'meeting', observed on linguistic, emotional, relational and political levels.
In an exchange of gestures, forms, actions, responsibilities and perspectives, the artists' pathways intersect for a project that will develop between October 2015 and March 2016 through work created during several periods of residence at the Tenuta Dello Scompiglio. The interventions, all closely linked to the context in which they are presented, yet projected towards an expanded horizon, were born from a reflection on place, the perception of belonging, and the physical, mental and imagined crossing of spaces.
In line with the broader dynamics of the three artists' research, the projects presented in I can reach you (from one to many) seek to develop the function of artistic practice into an open and interrogative process.
I can reach you is a collective meditation developed between the artists and curators questioning a possible position and the relations of exchange with surroundings, people, things. Bianco-Valente present an environmental installation centered on the resonances that all entities have between them and how these interact or influence our relationships. Claudia Losi, on the other hand, works on sensory places (landmarks) encountered along a walk to Scompiglio, places that become, either due to their own physical characteristics or due to events taking place, including distant landmarks, points of geographical-emotional density. "The idea is that the landmark is often created by us from scratch, in the experience that we have of a place, of passing through it". Lastly, Valerio Rocco Orlando, following a workshop focused on the idea of the wandering pilgrim and hospitality as a relational moment, creates an itinerant structure that moves along different stages of the Via Francigena, giving rise to, and in turn, leaving traces of its passage.
On October 3rd, an inaugural event will present the current state of these reflections, which will be further articulated over the following months with contributions from artists of other disciplines, to create an expanded, organic, heterogeneous fabric. The space of the exhibition will expand geographically, according to the program, which combines curatorial design with concerns of the artists, expanding beyond the confines of the Dello Scompiglio estate and multiplying with time, requiring new updates to the public. A calendar of these events will be announced later.
Giovanna Bianco was born in Latronico (Potenza) in 1962; Pino Valente was born in Napoli in 1967. They live in Napoli. Active since 1995, they work mainly with new media. Their research investigates issues that arise in the relationship between art and science: the human body in its entirety (mental-intangible/corporeal-biological molecular), human perception and space-time, memory.
Claudia Losi
Born in Piacenza in 1971, she studied at the Bologna Fine Arts Accademy and at the Faculty of Foreign Language and Literature. She participates in workshops and study courses in Italy and overseas. Her research focuses on the relationship of man to his surroundings, and between the individual and the community.
Valerio Rocco Orlando
Born in Milano in 1978, graduated in Dramaturgy at the Catholic University of Milan followed by a Master's Degree in Directing at Queen Mary University of London. He began his artistic career composing articulated installations, videos, films, photography and artists' books that, balancing choral dialogue and intimist painting, present the relationship between the individual and the community, in order to explore and rethink the sense of belonging to contemporary society.
Two of the curators are instructors at SACI: Daria Filardo and Pietro Gaglianò.
Associazione Culturale Dello Scompiglio
Via di Vorno, 67 – Vorno, Capannori (LUCCA)


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I was wondering if anyone has any experience with already designed qPCR primers? I've only ever designed my own ones when I was working with zebrafish and the process of testing and validating the primers before I can even use them for the real assay was very laborious and time consuming. I'm currently working with human samples now and OriGene offers predesigned, and I'm going to assume pre-tested, qPCR primers so I'm hoping it will cut down on the time I would need to test and validate the primers.
Does anyone have any experience with this kind of thing? If so, how was your experience?
Many thanks.


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Dec 7, 2018
Music selected by Twit One & FloFilz, recorded live at Carhartt WIP Store in Cologne.
From time to time we partner up with Carhartt WIP for live broadcasts from their stores or similar endeavours, and here's the place for the recordings of those sessions. Enjoy!
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The European Union's Constitutional Mosaic: Big 'C' or Small 'C', is that the Question?
EUROPE'S CONSTITUTIONAL MOSAIC, N. Walker, J. Shaw, S. Tierney, eds., Oxford: Hart, 2011
29 Pages Posted: 26 Oct 2010
Date Written: October 25, 2010
This paper examines Europe's Constitutional mosaic by focusing on the constitutional mosaic which makes up European Union constitutional discourse. It identifies the current state of EU constitutional discourse as a mosaic of different trends, the contours of which are briefly traced. It then argues that trends in EU constitutional discourse have ignored or suppressed the idea of sovereignty (hence the small 'c' adjective) and that this has resulted in difficulties both with relation to the conceptual coherence of constitutionalism and affects its usefulness as a way of understanding the polity. It argues that the constitutional idea is incorrigibly linked to the concept of sovereignty and that any constitutional discourse, even at the EU level, must entail sovereignty. It goes on to provide a sovereignty-inspired reading of EU constitutionalism through a particular reading of the European Court of Justice's constitutionalization of the Treaties and in its recent Kadi decision.
Keywords: Constitutionalism, Sovereignty, European Union, European Integration, Political Theory, Legal Theory, Philosophy,
Suggested Citation: Suggested Citation


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Dinner with a difference is back! After last year's resounding success, JRS Malta is once again organizing a series of east African meals at Selam Restaurant, Hamrun. For the prize of €15.00 per person, you can get choose from a variety of tradiational east African dishes, including: The traditional Injera, Doro Wat (Chicken stew), Berbere and Bersin (lentil stew). At the end of the evening, a traditional coffee ceremony will be held.
JRS in now taking bookings for the month of February and March. Dates available include Saturdays 28th Feb, 7th, 14th, 21st and 28th March. Space is limited, so book early to avoid disappointment!
For enquiries and reservation please call 21442751 or email email@example.com.
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Axis AX-XHH Hi-Hat Cymbal Stand
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6-Month* financing available.
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The Axis AX-XHH Hi-Hat Stand means you can play your hi-hat cymbals with the same precision and accuracy that is demanded from a second bass drum ped...Click To Read More About This Product
Brings new meaning to the term '4-way coordination.'
The Axis AX-XHH Hi-Hat Stand means you can play your hi-hat cymbals with the same precision and accuracy that is demanded from a second bass drum pedal thanks to the new "precision-pull" roller bearing design.
Precise spring tension is easily attained through the use of the 6-way "Set and Forget" pedal tension adjustment. Now you can quickly change and remember the pedal tension that is needed for different musical styles.
The AX-XHH is made of lightweight yet tough solid aluminum. The innovative new Vortex leg design is both strong and durable. The leg assembly on the AX-XHH was designed so that it can be freely rotated into any position for easier double pedal placement and tilts in any direction.
- "Precision-pull" roller bearing design
- 6-way "Set and Forget" pedal tension adjustment Quickly change and remember pedal tension settings for different musical styles
- Lightweight, yet tough, solid aluminum
- Leg assembly freely rotates and tilts for optimal placement
Position and play your hats with precision! Order your stand today.
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Gold Coverage goes above and beyond the manufacturer's warranty to protect your gear from unexpected breakdowns, accidental damage from handling and failures. This plan covers your product for one, two, three or up to five years from your date of purchase, costs just pennies per day and gives you a complete "no-worry" solution for protecting your investment.
Gold Coverage Includes:
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- For products over $200, No Lemon Policy applies. If it fails for the same defect 3 times, it is replaced on the 4th breakdown. (Does not apply to failures due to drops, spills, and cracks)
- For products under $200 experiencing the above failures, a Musician's Friend gift card will be issued for the full price of the product + tax.
- Shipping fees covered if required for repair or replacement
- Plans are transferable in the event merchandise is sold
- Plans are renewable on new gear
*Limitations and exclusions apply. See terms and conditions (Opens in new window) for program details
Term for New Gear begins on date of purchase but does not replace the store return policy or manufacturer coverage.


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Born Again Losers — Dr. Rick Hoover
Now that I have your attention I hope you will join me in this venture learning about losing and winning for born again Christians. This is my story about life and learning to live the Christian life that God desires.
Everyone has their 'ups and downs'. Our lives are somewhat defined by these events. But even more so, our lives are defined by how we handle these events. We can't choose what life throws at us but, we can choose what we do with it. The good, the bad, the pretty and the not so pretty will come. I can tell you that the best winning formula is the losing formula: the loss of self, the loss of pride, the loss of ego, and any other sin that besets us. The winning formula is to become a born-again loser!
Some people seem to be born winners. Everything they do seems to turn out just right. Have you ever noticed that and wondered why? It seems so unfair. They always make good decisions. They always come out ahead. They make good deals and prosper. But, of course I am speaking in terms the non-Christian world relates to.
But, clearly for the Biblical Christian, there is a distinct difference in how we describe winning and losing. The world's winners do prosper. They often gain the upper hand. They often come out ahead. In a strang
e way this is often not the way the Christian prospers.
Jesus said, "what would it profit a man if he gains the whole world and loses his soul"? Obviously that is a thought provoking question. Somehow, for the Christian, gaining and forfeiting, winning and losing have to be defined differently. If I play a game and win, but I cheat in the process, have I really won? If I win a contract in a business deal, but I twisted and doctored the figures to manipulate and confuse my client, have I really won?
There are obviously different ways to define winning. Most people would say I won and too bad for the other guy. But, in the Christian economy of doing things we simply must lose this kind of thinking. Thus, we have the Christian loser. As the Bible says, "the first shall be last and the last shall be first." (Mt. 20:16)
What I want to talk about is how to win by losing. It is a strange way of looking at life, but I believe it is the Biblical way and the way that all Christians need to follow in order to get to Heaven. My point is simple; the only way to winning in the Christian life is through losing. We must become born-again losers!


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Sandra Dickinson is an American actress and the mother of Georgia Moffett, the former wife of Peter Davison and the mother-in-law of David Tennant. In 1996, she appeared as Maggie in the audio serial The Ghosts of N-Space. She is known for her role as Trillian in the TV series adaptation of The Hitchhiker's Guide to the Galaxy.
External links Edit
Community content is available under CC-BY-SA unless otherwise noted.


text: Driving, mainly in the city, during hurry hour, or driving to some place that's unfamiliar can with a trying task. There's a couple of what exactly you need to bear in mind to be able to possess a more enjoyable driving experience. To begin with, when driving within the city, …Read More »


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A series of photos starring a female model wearing little to no clothing at Beijing's historic Forbidden City has lit up social media, much to the photographer's delight we're sure.
A viral image of the panty-less woman straddling the head of an ancient marble dragon at the formal imperial palace did not go over well with many Chinese web users. Neither did the picture of the model flashing her bare ass at the camera as she leaned over some stone handrails to enjoy a view of the iconic site.
"I was only doing my work and did not affect anyone," photographer Wang Dong reportedly said after web users accused him of 'profaning' cultural relics.
Palace Museum officials haven't yet commented on the seXXXy photo shoot, but a tourism expert cited in an SCMP report suggested that Wang would've been much better off taking the photos when the museum was closed to the public (and when young children weren't there to catch a surprise glance up the woman's not-so-forbidden nether regions).
Of course, this isn't the first time web users have gotten worked up over people using China's illustrious scenery as a backdrop for their nudie pics. Naked wedding photos taken by a couple at a Hunan scenic spot in December became something of a cause celebre after netizens called the Avatar-inspired shoot "immoral" and "distasteful".
The uncensored photos and more of the artist's work can be found here.
[Images via Weibo]


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Afterschool Club
Wondering what to do on these dark and wintry afternoons when the kids come home from school? Why not bring them down to the Treehouse and take advantage of our fantastic after-school deal! Unlimited play, and any kids meal & cordial for only £10! And we have daily after-school club activities for no extra charge! Wednesdays is Slime Time, Thursdays is Make Your Own Pizza, and every Friday there's a Superhero Glow in the Dark Disco in the party room! No booking required although you can book in advance for Slime Time and Superhero Glo Disco to secure your place as spaces are limited.
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Advantages of using solar power for your home
In the recent age solar power is the mostly used alternative fuel all around the world. People are choosing this source of energy for their electricity needs. Before shifting to solar power for your home you must be well aware about the solar energy pros and cons so that you can utilizeRead more


text: Donna was destined to be a writer - in the 4th grade she took her toy typewriter and painstakingly typed out the neighborhood news, one copy at a time, and sold it to the neighbors for ten cents. But writing would take a back seat to 30+ years in the IT industry. A late in life lover of adventure, she learned to ride a motorcycle at age 55, traveled the US solo on her Harley-Davidson at age 58 (42 states and 27k miles), selling her home and everything she owned to become a full-time RVer eventually where she met her current husband. They continued traveling in their 41' fifth wheel trailer (with room for their two motorcycles). In 2012 she decided to give fiction writing a try. Her first book, "Home Again" was a romance, quickly followed by the first two books in her Klondike Mystery series, "Not a Whisper" and "Barely a Spark".


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Weblog of Connie Vines, who resides deep within the suburbs of SoCal, with her hubby and a sassy toy poodle.
Friday, January 30, 2009
All Good Things Must End
As Bring a Character to Blog Week dies down, I'd like to thank all my guests. I'm sure you agree that my fellow authors who posted here this week have done a stellar job. I'm so pleased to host each and every one of them. To add to the fun, I'll be picking some lucky prize winners from among those who commented.
The first person will receive Witches Brew by Tabitha Shay. Tab is always a best-selling author at Eternal Press, and I see from the comments here, she's a big draw wherever she goes. I've had the pleasure of reading her work and becoming her friend, and both have been my pleasure. You can find out more about her and her work at Tabitha Shay
The second name drawn will receive Privy to Murder by Carol Shenold, another valued friend and colleague. Trust me when I tell you that Carol has a captivating style in mystery writing. To find out more about Carol and her books, please visit Carol's Website .
And last, but certainly not least, the third name drawn will receive The Cross of Tarlis by Julie D'Arcy. Without Julie, I would never have found Eternal Press. I owe a lot to her. Her book is listed as a paranormal sci/fi, packed with action and adventure. Julie has taken a respite from writing, but you can find more about her books at All Romance Ebooks
I thank these three ladies for donating their hard work for your free enjoyment. I'll be drawing names on Sunday and announcing the winners on Monday, here on the blog. Please check back and see if you happen to be one of the lucky visitors. *smile*
2 comments:
- LuAnn said...
You certainly have had some great columns this week! Thanks.
- January 30, 2009 at 8:00 PM
- Unknown said...
Yes, I have! This 'topic' greatly exceeded my expectations. What a talented group. :)
- January 31, 2009 at 3:10 PM
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Submit Search
Set of 2
Add Powerful Hydrotherapy jets including dual adjustable air intakes for added pressure control. You have 4 jets with most of our heating systems. You can add jets to a total of 6 or 8. They need to be ordered in sets of 2 because the pumps are automatically adjusted at the time of purchase.
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Reactoonz is a Play 'N Go slot playable on a 7x7 grid; this alien-themed title uses the cascading game engine that is becoming fast popular where players can win again from a second attempt on the same spin.
With every win, players charge up the meters to randomly activate one of five Quantum round which gives them wild icon transformations, low-value symbol transformations, low-value icon destructions, intersecting wilds and an oddly-named Gargantoon that adds either 1x1, 2x2 or 3x3 wilds on the reels.
There are also random wilds, x2 wins on four matching icons resembling a 2x2 shape and fluctuating symbols that give players more wilds. Highly volatile, players can win up to a whopping 4,570 times their bet stake on every cascade.
Players must aim to collect clusters of energetic extra-terrestrials characters. These cutesy, alien theme-cartoon style symbols on the reels include four lower paying aliens, four higher-paying aliens and the vortex wild. The highest-value symbol is the pink alien who awards players 750 times their stake for accumulating five across a payline. The vortex wild substitutes all other icons to help generate more winning combinations.
As mentioned above, Reactoonz uses a cascading game engine with icons cascading down into the 7x7 grid where players will aim to form winning combinations for getting five of a kind in one cluster, either vertically or horizontally.
Once players obtain a win, the contributing icons are then removed with newer symbols filling up their empty spaces and form new wins, so, seriously boosting a players winnings. The cascading symbols continue to drop until either all the empty spaces are filled or players are not able to create more winning formations.
With every win obtained, players increase the five Quantum Leap charge meters one by one – when a meter is charged, one of the quantum features is randomly added to the queue:
Implosion feature – three to six icons are transformed into wilds with adjoining symbols also being destroyed.
Alteration feature – one random low-value icon is chosen with all instances of that symbol converting into another icon. If there's no low-value symbol on the grid, a high-value alien will be selected.
Demotion feature – all cases of low-value icons are destroyed and excluded from the gird.
Incision feature – a wild is made into the centre that then creates two intersecting diagonal lines through the grid. This then displays the same randomly selected icon.
When all five charge meters are fully charged, the Gargantoon feature is attached to the queue; the Gargantoon will add a 3x3 wild on the grid. With each cascade, the Gargantoon splits to become two 2x2 wilds. With the next cascade, it splits again into nine 1x1 wilds.
However, players should note that the Gargantoon can randomly drop four to eight wild icons onto the grid if players have a non-winning spin – this is known as the Instability round. Reactoonz benefits from a Giantoonz round – this is played when four matching icons next to each other in a square shape 2x2 surface. This will form Giantoonz, meaning that wins are doubled (i.e. x2 multiplier) in any winning combo.
Finally, there is a Fluctuation round – one random low-value icon is marked as the fluctuating symbol on each spin. This round will leave two wilds behind the grid should it form part of a winning combination.
Reactoonz may sound rather complicated; however its rather easy once players get playing – its fast-paced, fun and has very high variance as players win up to 4,570 times their bet stake on every cascade or spin.
Words: David Bailey-Lauring
Images: Bitcasino
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The Union Hotel is a retro brick building in Newtown, New South Wales, just north of Sydney Park. You can find it right off A36. The Union Hotel is true to its roots. It keeps the front bar as homely as it's ever been. It is a large open space with two pool tables and a music venue. It is the kind of place you'd like to spend a lazy afternoon with friends drinking beer. Then you can settle in for a night of live and local music. The front bar has a very welcoming and local atmosphere. This hotel has been renovated in recent years and all the renovations were focused on the back bar and restaurant. The restaurant now has an industrial chic feel. The menu draws influences from diners in America, mainly in Chicago and New York. It is full of Australian and American sandwiches and burgers. There is a lovely little outdoor area where you can enjoy a meal and a drink. Romantic lighting fixtures hang low and there's plenty of greenery. It's the perfect spot to enjoy a daily special at the Union Hotel. Monday and Tuesday draw the younger crowd with free pool and Nintendo 64. Monday is for discounted burgers and Tuesday gets you discounted schnitzel. Trivia is on Wednesday nights and there is a raffle on Thursday nights. And Thursday through Sunday is for live and local music. This is a great hotel to get social with locals and to grab a good meal.
Sun 10:00 - 22:00
Mon 10:00 - 00:00
Tue 10:00 - 00:00
Wed 10:00 - 00:00
Thu 10:00 - 02:00
Fri 10:00 - 02:00
Sat 10:00 - 02:00
Address: 576 King Street, Newtown NSW 2042


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Sweat the Small Stuff: Teeniest Aβ Oligomers Wreak Most Havoc
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As anyone who has rinsed off after frolicing on a beach knows, tiny particles weasel their way into tight spaces and are far more troublesome than larger ones. The same seems true of soluble aggregates of Aβ, according to a study published January 4 in the Journal of Neuroscience. Researchers led by Dennis Selkoe and Dominic Walsh at Brigham and Women's Hospital in Boston reported that large soluble oligomers make up the vast majority of soluble Aβ aggregates in the AD brain, yet have minimal cytotoxic power. However, when the researchers let those larger aggregates dissociate, they liberated tiny Aβ clusters that packed an outsized punch—dampening synaptic activity in hippocampal neurons and instigating inflammatory microglial responses in the mouse brain. Conditions that destabilize high molecular weight oligomers or prevent the sequestration of smaller ones could contribute to Aβ toxicity, the researchers concluded.
By virtue of their size, and possibly other biochemical characteristics, these smallest aggregates may cause the most damage by deftly squeezing into cramped spaces like synapses and interacting with cellular membranes, Selkoe told Alzforum. "The smaller an aggregate is, the more likely it is to cause trouble," he said.
Most researchers agree that soluble Aβ oligomers can exact a toxic toll on neurons, but efforts to examine these pesky Aβ species have been complicated by the very attributes that might make them so toxic: The hydrophobic aggregates readily cling to plastic tubes and pipettes, and interact with each other to shape-shift. Recently, researchers led by David Brody and colleagues at Washington University in St. Louis developed a detailed protocol to isolate soluble aggregates of Aβ from postmortem AD brain extracts, and reported that a majority of aggregates were of high molecular weight (see May 2016 news). However, previous studies led by Selkoe and colleagues reported that while scarce, small oligomers—dimers in particular—caused the most cellular damage (see Jun 2008 news; Nov 2007 conference news).
For the current study, first author Ting Yang and colleagues wanted to directly compare the toxicity of small and large oligomers and determine whether the latter serve as a reservoir for tinier, more noxious species. The researchers prepared postmortem brain extracts from the frontal cortices of six AD patients and five non-AD controls. After a centrifugation to remove insoluble and membrane-associated material, they obtained a mixture containing soluble Aβ species that they then probed with antibodies specific for either monomeric (mAβ 266) or oligomeric (mAβ 1C22) Aβ. They found that in extracts from AD patients, the majority of Aβ existed as oligomeric species. In contrast, monomeric Aβ dominated extracts from healthy controls.
To assess the size of oligomers, the researchers ran the AD brain extracts on size-exclusion chromatography columns followed by western blotting. They found that most soluble Aβ weighed between 150 kDa and 600 kDa. Denaturing these larger conglomerates with detergent yielded both monomers (~4 kDa) and dimers (~7.5 kDa). Yang and colleagues next asked whether dissociating the larger oligomers in non-denaturing conditions might yield smaller oligomers that could contain neurotoxic species. They eluted larger oligomers (greater than 150 kDa) from the size-exclusion column using an alkaline buffer, and left them to marinate in this basic solution at 37° for two days. They found that the alkaline bath caused most oligomers to dissociate, raising levels of monomers and dimers. While a substantial amount of total Aβ was lost between the pre- and post-incubation samples, Selkoe told Alzforum this was at least partly due to oligomers' infamous stickiness to tubes and pipettes.
Which size oligomer would most aggravate cells in the brain? The researchers first addressed this question by adding the larger oligomers (>150 kDa), either with or without a two-day dissociation in alkaline buffer, to hippocampal slice cultures to measure effects on long-term potentiation (LTP), a cardinal proxy of neural plasticity. The large oligomers had minimal effects on LTP, but the dissociated, smaller oligomers suppressed it. On average, neurons exposed to large oligomers prepared from any of the six AD brain samples had a 48 percent potentiation of excitatory postsynaptic potential in response to electrical stimulation, while neurons exposed to small oligomers mustered only a 29 percent uptick. LTP was unimpeded when the researchers immunodepleted Aβ first. Small, but not large, oligomers also reduced the expression of β2-adrenergic receptor on the neuronal surface by 40 percent, in keeping with previous reports that oligomers trigger the internalization and degradation of these and other receptors (see Wang et al., 2011; Li et al., 2013).
Selkoe and colleagues had previously reported that Aβ oligomers activated microglia and ramped up their expression of pro-inflammatory cytokines, but what size of oligomers did this was unknown (see Xu et al., 2016). To address this, the researchers injected either large or dissociated/small oligomer mixtures from AD brain extracts directly into the ventricles of healthy, wild-type mice, then examined the activation state of the microglia in the hippocampal and perihippocampal regions after two days. Compared to microglia in mice injected with large oligomers, those in animals treated with small oligomers were rounder and had fewer branches, and expressed higher levels of the activation marker CD68. The researchers concluded that small oligomers fired up microglia, which could trigger damaging neuroinflammatory responses in the brain.
Tiny Terrors. Microglia (expressing P2ry12, red) in the cornu ammonis (top panel) and the dentate gyrus (bottom panel) of the hippocampus round up retract their processes, and express CD68 (white) in response to small, dissociated oligomers (middle). They did not respond to large oligomers (left), or extracts of immonodepleted of Aβ (right). [Courtesy of Yang et al., The Journal of Neuroscience, 2017.]
Overall, the findings paint small oligomers, not their larger forebears, as cerebral agitators, Selkoe told Alzforum. "They also support the conclusion that a huge proportion of soluble Aβ oligomers have no bioactivity," he added. He thinks a continuous release of small oligomers from larger forms explains why oligomer-specific antibodies detect Aβ around plaques, and why synapses wither in their vicinity (see Feb 2009 news). Selkoe believes that the Aβ dimers released by detergent or alkali represent a particularly toxic, covalently bonded form of oligomer.
Lars Lannfelt of Uppsala University in Sweden questioned how the dissociation of large oligomers in alkaline solution would relate to conditions in the AD brain. "During 48 hours at 37°C, many things can happen, including protease activity changing the nature of the oligomers," he wrote in a joint comment with Dag Sehlin of Uppsala and Pär Gellerfors, Hanna Laudon, and Linda Söderberg of BioArctic in Stockholm. Selkoe acknowledged that these dissociation conditions are not entirely physiological, however he speculated that similar dissociation likely happens under neutral pH conditions in the brain, albeit over a much longer timescale.
Dietmar Thal of KU Leuven in Belgium said that artificial conditions are a necessary evil in any study making use of postmortem brain extracts or modeling potentially pathological events, but that Yang and colleagues did an excellent job at controlling them. He added that the preponderance of large oligomers in the AD brain agrees with findings from his previous study, which used different methods to come to the same conclusion (see Upadhaya et al., 2011). Lannfelt's previous work also found a preponderance of large oligomers in the brain. However, using synthetic oligomers, Lannfelt and colleagues came to the conclusion that both large and small species were cytotoxic (see Sehlin et al., 2012).
Thal added that it will be crucial to address how the dissociation of these large oligomers into smaller, toxic forms is influenced by other proteins in the brain, and by post-translational modifications of Aβ such as phosphorylation and pyroglutamate modification. Erik Portelius of the University of Gothenburg in Sweden echoed Thal, pointing out that researchers will need to determine what characteristics—beyond size—distinguish neuroactive from benign Aβ aggregates. He added that if detectable in cerebrospinal fluid, these small oligomers would likely serve as very early markers of AD.
How might these findings inform therapeutic efforts to target Aβ? Selkoe said that targeting either small oligomers or their more abundant reservoirs of large oligomers could hold promise of slowing neuronal damage. He added that perhaps antibodies raised specifically against small oligomers dissociated from larger ones might directly target the most troublesome aggregates.
Lannfelt and colleagues have targeted the larger oligomers, also dubbed "protofibrils," with a monoclonal antibody, BAN2401, that is now in Phase 2 clinical trials for AD. Other antibodies raised to Aβ epitopes also recognize oligomers and larger fibrils (see May 2015 news).
"The hot debate at the moment is which of the current antibodies (and other compounds targeting Aβ oligomers) in clinical development have the best chance of either neutralizing the toxic effects, binding and activating microglial clearance pathways, or simply shifting the equilibrium between the different Aβ conformers," commented Colin Masters of the University of Melbourne in Australia. Selkoe said his lab seeks to address that question by comparing the size of oligomers engaged by different therapeutic antibodies.—Jessica Shugart
The experience from genetic findings in the early 1990s strongly point to Aβ as the culprit in Alzheimer's disease. However, we still do not understand how Aβ confers cognitive dysfunctions and neuronal atrophy. For several years we have witnessed an increased interest in soluble Aβ oligomers as being the important pathogenic form of Aβ (Liu et al., 2015; Esparza et al., 2016). This paper by Yang et al. demonstrates that the predominant forms of soluble Aβ in human Alzheimer brain are higher molecular weight (HMW) oligomers. HMW oligomers eluted in the void volume of a size exclusion chromatography Superdex 75 column. The investigators then incubate these species in an alkaline buffer for 48 hours at 37°C, which leads to degradation into lower molecular weight (LMW) oligomers. The authors claim that toxicity of Aβ is mainly conferred by the small oligomers and not by the HMW oligomers, as demonstrated by effects by in vitro methods such as hippocampal LTP, activation of microglia and effect on neuronal levels of β2-adrenergic receptors.
We have made a similar observation that the major soluble Aβ species in Alzheimer brain were HMW oligomers, but used ultracentrifugation. However, toxicity between synthetic HMW and LMW oligomers were approximately similar (Sehlin et al., 2012). By using synthetic Aβ we had previously found a fraction eluting in the void of a Superdex 75 column. This pool of oligomeric Aβ, of different sizes, we named protofibrils (Nilsberth et al., 2001). This name had been used previously (Walsh et al., 1997), and we found it appropriate to use the nomenclature of previous authors. The propensity to form protofibrils was greatly enhanced by the Arctic APP (E693G) mutation inside Aβ leading to early onset Alzheimer's disease. We later developed an antibody against Aβ protofibrils, mAβ158 (Englund et al., 2007). The humanized version of the antibody, BAN2401, is now in a large clinical trial against Alzheimer's disease, run by Eisai and BioArctic (Lannfelt et al., 2015). We have also used this antibody to visualize Aβ protofibrils in two AβPP-transgenic mouse models with PET (Sehlin et al., 2016), clearly demonstrating that these Aβ species are formed in vivo and are accessible to antibodies penetrating the brain.
It is very difficult to study what is actually ongoing in the brains of Alzheimer patients. All our efforts and methods are indirect, as we at present are unable to monitor the biochemical processes that are taking place in vivo in the human brain. Thus, it is not certain that the in vitro studies used in the present paper mimic the disease processes in Alzheimer brains. Furthermore, it is unclear why the experiment was performed where the HMW material eluting in the void volume of the SEC column was subjected to degradation in alkaline conditions during 48 hours at 37°C. Is this something that reflects processes in the human Alzheimer brain? During 48 hours at 37°C many things can happen, including protease activity changing the nature of the oligomers.
Solanezumab, a monoclonal antibody targeting the monomer of Aβ, recently failed to show clinical efficacy (see Dec 2016 conference news). However, aducanumab, an antibody with a very different Aβ-binding profile than solaneuzumab, has demonstrated a clinical effect on cognition and also reduction of Aβ plaque load as measured by amyloid PET (Sevigny et al., 2016). In contrast to solanezumab, the Aβ-binding profile of aducanumab is shifted to the "right," i. e., toward HMW Aβ oligomers and fibrils. Sevigny et al. demonstrated that aducanumab mainly binds to Aβ fibrils and oligomers, with no monomer binding. If, as the authors suggest, the toxic effect of Aβ is caused by LMW oligomers in vivo, targeting HMW oligomers will still be beneficial since it will remove the proposed precursor of the LMW oligomers.
With this in mind it is uncertain if the in vitro experiments in Yang et al. reflect the biochemical processes of Aβ aggregation in the brains of patients with Alzheimer's disease. However, it is very important to understand that our scientific efforts are hampered by our lack of basic knowledge of the in vivo pathogenic processes in the human Alzheimer brain. Our conclusion is that our knowledge at present is limited, but there are certain evidences that soluble aggregated forms of Aβ are a main player in toxicity and confer neurodegeneration in Alzheimer's disease. In previous papers some of these authors have strongly claimed that the Aβ dimer is the main cause of neurotoxicity (Shankar et al., 2008). Our position is that we do not fully understand the nature of what is killing neurons in Alzheimer's disease, although soluble aggregated forms of Aβ are a prime suspect.
Pär Gellerfors of BioArctic are also co-authors of this comment.
Englund H, Sehlin D, Johansson AS, Nilsson LN, Gellerfors P, Paulie S, Lannfelt L, Pettersson FE. Sensitive ELISA detection of amyloid-beta protofibrils in biological samples. J Neurochem. 2007 Oct;103(1):334-45. PubMed.
Esparza TJ, Wildburger NC, Jiang H, Gangolli M, Cairns NJ, Bateman RJ, Brody DL. Soluble Amyloid-beta Aggregates from Human Alzheimer's Disease Brains. Sci Rep. 2016 Dec 5;6:38187. PubMed.
Lannfelt L, Möller C, Basun H, Osswald G, Sehlin D, Satlin A, Logovinsky V, Gellerfors P. Perspectives on future Alzheimer therapies: amyloid-β protofibrils - a new target for immunotherapy with BAN2401 in Alzheimer's disease. Alzheimers Res Ther. 2014;6(2):16. Epub 2014 Mar 24 PubMed.
Liu P, Reed MN, Kotilinek LA, Grant MK, Forster CL, Qiang W, Shapiro SL, Reichl JH, Chiang AC, Jankowsky JL, Wilmot CM, Cleary JP, Zahs KR, Ashe KH. Quaternary Structure Defines a Large Class of Amyloid-β Oligomers Neutralized by Sequestration. Cell Rep. 2015 Jun 23;11(11):1760-71. Epub 2015 Jun 4 PubMed.
Nilsberth C, Westlind-Danielsson A, Eckman CB, Condron MM, Axelman K, Forsell C, Stenh C, Luthman J, Teplow DB, Younkin SG, Näslund J, Lannfelt L. The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation. Nat Neurosci. 2001 Sep;4(9):887-93. PubMed.
Sehlin D, Englund H, Simu B, Karlsson M, Ingelsson M, Nikolajeff F, Lannfelt L, Pettersson FE. Large aggregates are the major soluble Aβ species in AD brain fractionated with density gradient ultracentrifugation. PLoS One. 2012;7(2):e32014. PubMed.
Sehlin D, Fang XT, Cato L, Antoni G, Lannfelt L, Syvänen S. Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer's disease. Nat Commun. 2016 Feb 19;7:10759. PubMed.
Sevigny J, Chiao P, Bussière T, Weinreb PH, Williams L, Maier M, Dunstan R, Salloway S, Chen T, Ling Y, O'Gorman J, Qian F, Arastu M, Li M, Chollate S, Brennan MS, Quintero-Monzon O, Scannevin RH, Arnold HM, Engber T, Rhodes K, Ferrero J, Hang Y, Mikulskis A, Grimm J, Hock C, Nitsch RM, Sandrock A. The antibody aducanumab reduces Aβ plaques in Alzheimer's disease. Nature. 2016 Aug 31;537(7618):50-6. PubMed.
Shankar GM, Li S, Mehta TH, Garcia-Munoz A, Shepardson NE, Smith I, Brett FM, Farrell MA, Rowan MJ, Lemere CA, Regan CM, Walsh DM, Sabatini BL, Selkoe DJ. Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat Med. 2008 Aug;14(8):837-42. PubMed.
Walsh DM, Lomakin A, Benedek GB, Condron MM, Teplow DB. Amyloid beta-protein fibrillogenesis. Detection of a protofibrillar intermediate. J Biol Chem. 1997 Aug 29;272(35):22364-72. PubMed.
Make a Comment
News Citations
- Aβ Oligomers Purified from Human Brain
- Paper Alert: Patient Aβ Dimers Impair Plasticity, Memory
- San Diego: Oligomers Live Up to Bad Reputation, Part 1
- Spine Shrinkers: Aβ Oligomers Caught in the Act
- Shape of a Hug: How the Embrace of a Therapeutic Aβ Antibody Really Matters
Antibody Citations
Therapeutics Citations
Paper Citations
- Wang D, Yuen EY, Zhou Y, Yan Z, Xiang YK. Amyloid beta peptide-(1-42) induces internalization and degradation of beta2 adrenergic receptors in prefrontal cortical neurons. J Biol Chem. 2011 Sep 9;286(36):31852-63. PubMed.
- Li S, Jin M, Zhang D, Yang T, Koeglsperger T, Fu H, Selkoe DJ. Environmental novelty activates β2-adrenergic signaling to prevent the impairment of hippocampal LTP by Aβ oligomers. Neuron. 2013 Mar 6;77(5):929-41. PubMed.
- Xu H, Gelyana E, Rajsombath M, Yang T, Li S, Selkoe D. Environmental Enrichment Potently Prevents Microglia-Mediated Neuroinflammation by Human Amyloid β-Protein Oligomers. J Neurosci. 2016 Aug 31;36(35):9041-56. PubMed.
- Upadhaya AR, Lungrin I, Yamaguchi H, Fändrich M, Thal DR. High-molecular weight Aβ-oligomers and protofibrils are the predominant Aβ-species in the native soluble protein fraction of the AD brain. J Cell Mol Med. 2011 Mar 21; PubMed.
- Sehlin D, Englund H, Simu B, Karlsson M, Ingelsson M, Nikolajeff F, Lannfelt L, Pettersson FE. Large aggregates are the major soluble Aβ species in AD brain fractionated with density gradient ultracentrifugation. PLoS One. 2012;7(2):e32014. PubMed.
Further Reading
No Available Further Reading
Primary Papers
- Yang T, Li S, Xu H, Walsh DM, Selkoe DJ. Large Soluble Oligomers of Amyloid β-Protein from Alzheimer Brain Are Far Less Neuroactive Than the Smaller Oligomers to Which They Dissociate. J Neurosci. 2017 Jan 4;37(1):152-163. PubMed.
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Further Reading
- Inventing the Professor
- Jeana Jorgensen, PhD Folklore and Dance
- The Ambulant Scholar
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text:
So my Mom called last night and asked for a wedding card...last minute. Of course I said I'd make her one, so off to my room I go.
Over at Splitcoaststampers, last weeks CAS challenge was to make a wedding card. I didn't have a need for a wedding card so I thought I'd skip that one and wait for the next. Well, who knew?!
Anyway, this card uses PTI cardstocks, Stampin' Up stamps, chalk inks, and Nesties in the Cuttlebug.
Friday, September 25, 2009
Colorado Wedding
Labels: Splitcoaststampers, Stampin' Up
4 comments:
- Heather Schlatter said...
This card turned out really pretty!!! Just wanted to get by and make sure to give you a Proper welcome to the Character Cafe DT!!!
Looking forward to working with you and getting to know you!!!
I see you design for Ai Factory two of the girls that I design with on the Etsy Inspired DT are on that team Ashley and De???
- September 26, 2009 at 1:17 PM
- Heather Schlatter said...
Ooops forgot to say I got you added to my followers list so I can come back often and keep up with your very cute creations!!! I looked through the last couple of pages CUTE stuff!!!
- September 26, 2009 at 1:19 PM
- de said...
Lola, this is so pretty! It's sure to be a smash for the wedding!
- September 27, 2009 at 9:44 AM
- Sara said...
ooooooh, this is so pretty! Love the white with the blue!
- September 27, 2009 at 7:05 PM
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