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Fight Aging! Newsletter, September 3rd 2012
September 3rd 2012
The Fight Aging! Newsletter is a weekly email containing news, opinions, and happenings for people interested in aging science and engineered longevity: making use of diet, lifestyle choices, technology, and proven medical advances to live healthy, longer lives. This newsletter is published under the Creative Commons Attribution 3.0 license. In short, this means that you are encouraged to republish and rewrite it in any way you see fit, the only requirements being that you provide attribution and a link to Fight Aging!
- A Perspective on Progress in Longevity Science
- What's Really Delaying the Defeat of Aging?
- Absent Optimism
- Everyone Has a Plan to Save Medicare
- Discussion
- Latest Headlines from Fight Aging!
- SIRT6 Overexpression Reverses DNA Repair Decline in Aging Mice
- A Good Lifestyle Makes a Difference Even Late in Life
- Impact of Mid-Life Fitness on Later Risk of Age-Related Disease
- No Extension of Average Lifespan in Primate Study of Calorie Restriction
- A View of Diet and Aging
- Work on Blocking Damage in Brain Injury
- More on DNA Methylation and Human Longevity
- Cytomegalovirus and Type 2 Diabetes Risk
- How Long Do You Want to Live?
- Wiring Up Engineered Tissue
Here is an overview of some of what I see when looking out on the world of research and development relating to engineered longevity, spurred by someone who asked whether it was plausible for aging to be defeated by 2029:
"The bottom line is that the research community and state of the field today is very different from that of even a mere ten years ago. This is a time of rapid change and progress: far more is known and far more impressive feats of medicine can be performed in the lab and the clinic. There is every reason to believe that ten years from now we'll be able to say the same thing. Costs in biotechnology and life science research are falling rapidly, and with that trend more research can be accomplished in each new year.
"That said, however, the only way that we'll see significant inroads into the defeat of aging by 2029 is for the SENS Foundation and its attendant research community to undergo the same sort of growth over the next decade as has been exhibited in recent years by regenerative medicine, calorie restriction research, or study of the genetics of longevity. A growth to billions in funding and thousands of researchers, in other words. It will require at least that and a decade of time in order to have a 50/50 shot at reversing aging in old mice in the lab - which is to say something that can make them live at least twice as long as they otherwise would have done.
"Of all the items covered in this post, only SENS provides a path towards achieving this end. Even regenerative medicine and complete control over stem cells can't offer the possibility of reversing aging in and of itself - it is only the way to reverse one component of aging, the decline of tissue maintenance and frailty that results from stem cells shutting down. You will still get nailed by your own mitochondria and the build up of metabolic byproducts even if your stem cells are perfectly restored.
"[So], no, there is no plausible road to the defeat of aging by 2029. But there is a plausible road to the first laboratory demonstrations of real, meaningful, but partial age reversal by then, ways to actually repair the root biological causes of aging rather than just slow it down. Whether that happens or not depends absolutely on funding - there are more than enough scientists and research groups out there who would work on the SENS vision for rejuvenation biotechnology if given a budget, but as of yet not enough funding sources to make it a reality."
Aubrey de Grey of the SENS Foundation answers this question in an open access editorial from the Rejuvenation Research journal:
"In the mid-1990s, when I decided to switch from computer science to gerontology, I recognized that the creation of a credible assault on aging would require solving three basic problems: (1) Creating a credible plan; (2) getting the people best placed to implement it to be interested in doing so; and (3) giving them the financial resources to get on with the job.
"I broke the back of the first problem in mid-2000, when I realized that regenerative medicine - repairing the accumulating damage of aging - will probably be far simpler and easier to implement than the alternative followed by most biogerontologists, namely slowing the creation of that damage. By that time, I had also done most of the heavy lifting of item 2 (as I continued to do thereafter), by connecting with leading researchers worldwide, mostly face to face at conferences, and improving their understanding of how their expertise could be productively applied to aging. By way of illustration, quite a few of the most prestigious such people are named on the front cover of this journal as associate editors, and they accepted such a position for that reason. But what about item 3?
"Unfortunately, I cannot tell so positive a story with respect to financial resources. Nearly a decade ago, I began to make public predictions of how soon we would achieve success in our crusade. I did so, as I still do, in the manner that (for better or worse) preoccupies the general public, namely in terms of longevity, but I have always been careful to incorporate two key caveats: (1) The level of uncertainty of the time frames, even if only scientific uncertainty is considered, and (2) the reliance of such estimates on adequate funding.
"The first of these caveats is often elided, but it is simple: I estimate that we have a 50% chance of achieving the milestone of "robust human rejuvenation" (essentially, the rejuvenation of 60 year olds comprehensively enough that they won't be biologically 60 again until they're chronologically 90) within 25 years, but I also estimate that we have at least a 10% chance of not getting there in 100 years. But...that is all subject to the second caveat, namely funding.
"Tragically, the level of funding that has been forthcoming during the past decade is only a few percent (at most) of what is necessary. The rate of progress in research to defeat aging has been quite amazing in view of that, but nonetheless, I estimate that it has been only about one-third of what could have been achieved with 10-20 times more money."
Our culture is far too short-sighted, focused on what is, and pessimistic, and that harms the prospects for progress:
"For a society in the midst of accelerating, rapid, and evident technological progress, public discussion and attitudes show a surprising lack of optimism for the future. Optimism of course exists, but nowhere near as widely as it should. It seems self-evident at this point that a golden era lies ahead in which we defeat disease and aging, colonize the solar system, and expand the limits of what it means to be human. We and our descendants will discard pain and suffering along the way, just as we have already discarded so much of the pain and suffering that our ancestors bore. ... The upward ramp of the necessary underlying technology is within our grasp. But you wouldn't think this from listening to the public. Much of the world seems convinced that nothing but collapse and catastrophe lies ahead: their view of the future is the ever-mistaken Malthusian collection of beliefs revolving around static resources that are exhausted. They fail to see the dynamism of resource generation and progress that proved past Mathusians just as wrong as the present crop."
There are any number of people out there putting forward their proposals:
"Having a plan to save Medicare is somewhat like wearing a tie or cufflinks, in that it is somewhat de reigueur in some parts of society - but ultimately a cultural signal of belonging, of little value otherwise. The economic future of the US is somewhat grim; the decline of an empire is inevitable as its increasingly unaccountable elite class debauch the currency, centralize power, and regulate all aspects of a citizen's life. They tax and waste ever more of the flow of resources whilst destroying the freedom and competition needed for the creation of those resources - in much the same way as a cancer is parasitic to its host but ultimately destroys both host and itself. This is an inexorable progression of society, built upon the foundation of human nature and the individual actions and interactions of millions of people. It has happened over and again and is just about as likely as the tide to be turned aside.
"So having a plan to save Medicare is rather like having a plan to save a part of your cancer. That portion in the lower left, perhaps. Medicare is but one part of the network of regulation, perverse incentives, and regulatory capture that causes medicine in the US to be ever more expensive, wasteful, and poor in quality. It's large enough to be considered in the context of the more general economic decline across the board, which occurs for roughly the same set of reasons, and is just as hard to turn back. Medicine is in a more advanced state of socialist decrepitude than most other US industries, but the same process operates throughout society.
"From there let me segue into a discussion of responses to shortage. Regulation inevitably creates shortage and rationing: we see this in the provision of medicine in countries like Canada and the UK, where regulators set up waiting systems or simply forbid treatment, especially to the old. Much of the public discussion that results from this state of affairs looks at what to do about the shortages - though of course without a great deal of reflection on how they came to exist in the first place, sad to say. There are two broad lines of thinking here: firstly, use less of whatever is rationed; secondly try to create more of whatever is in short supply.
"One of the defining and frankly rather sorry aspects of our age is that public debates veer towards cutting back on use far more often than towards creating abundance. See the bulk of the environmentalist or other Malthusian movements for example - they have little to say about building more of whatever it is they think is in short supply.
"When it comes to Medicare, and given that very few people are calling to get rid of the whole system and let freedom and free markets rule the day, the two sides of the coin look much like (a) a call for increased rationing of services to ensure that people use less in the way of medicine, and (b) a call for ways to create greater health such that people use less in the way of medicine. There are of course many different approaches to either of these paths, but both ultimately sidestep the real issue, the real cause of the problem - and this again is absolutely characteristic of debate over societal organization and politics in our age."
The highlights and headlines from the past week follow below. Remember - if you like this newsletter, the chances are that your friends will find it useful too. Forward it on, or post a copy to your favorite online communities. Encourage the people you know to pitch in and make a difference to the future of health and longevity!
Friday, August 31, 2012
This interesting research result adds a little more to the debate over whether nuclear DNA damage is relevant to aging beyond its effects on cancer risk - though I think it's still a bit early to point to differences in DNA repair as the definitive cause of SIRT6-related longevity in mice: researchers "found that the decline in a cell's ability to repair DNA during aging coincided with a global reduction in the levels of proteins involved in the repair process. [They] tried to reverse the age-related decline in DNA repair efficiency by restoring the proteins to their original levels and found only one protein, SIRT6, did the trick. ... [Other research results have shown] that overexpressing the SIRT6 protein extended the lifespans of mice. Our research looked at DNA repair and found a reason for the increased longevity, and that is SIRT6's role in promoting more efficient DNA repair. ... The next step [is] to study the factors that regulate SIRT6, in an effort to learn more about the early stages of the DNA repair process. ... multiple groups are trying to develop drugs that activate SIRT6, and [researchers hope] that this research will one day lead to therapies that help extend a person's lifespan and treat cancer. ... SIRT6 plays a critical role in repairing the most dangerous type of DNA damage: double-strand breaks. DNA is a two-stranded molecule, and breaks can occur to one strand of the molecule or to both. In the case of single-strand breaks, the unbroken strand guides the repair process and the DNA molecule is typically restored to its original state. However, double-strand breaks, in which both strands are severed, are particularly hazardous because they are more difficult to repair and can lead to a rearrangement of the cell's genetic material."
Friday, August 31, 2012
Keeping up on the health basics makes a difference even in the last years of life: "It is well known that lifestyle factors, like being overweight, smoking and heavy drinking, predict death among elderly people. But is it uncertain whether these associations are applicable to people aged 75 years or more. So a team of researchers based in Sweden measured the differences in survival among adults aged 75 and older based on modifiable factors such as lifestyle behaviours, leisure activities, and social networks. The study involved just over 1,800 individuals who were followed for 18 years (1987-2005). Data on age, sex, occupation, education, lifestyle behaviours, social network and leisure activities were recorded. During the follow-up period 92% of participants died. Half of the participants lived longer than 90 years. Survivors were more likely to be women, be highly educated, have healthy lifestyle behaviours, have a better social network, and participate in more leisure activities than non-survivors. The results show that smokers died one year earlier than non-smokers. Former smokers had a similar pattern of survival to never smokers, suggesting that quitting smoking in middle age reduces the effect on mortality. Of the leisure activities, physical activity was most strongly associated with survival. The average age at death of participants who regularly swam, walked or did gymnastics was two years greater than those who did not. Overall, the average survival of people with a low risk profile (healthy lifestyle behaviours, participation in at least one leisure activity, and a rich or moderate social network) was 5.4 years longer than those with a high risk profile (unhealthy lifestyle behaviours, no participation in leisure activities, and a limited or poor social network). Even among those aged 85 years or older and people with chronic conditions, the average age at death was four years higher for those with a low risk profile compared with those with a high risk profile. In summary, the associations between leisure activity, not smoking, and increased survival still existed in those aged 75 years or more, with women's lives prolonged by five years and men's by six years, say the authors. These associations, although attenuated, were still present among people aged 85 or more and in those with chronic conditions."
Thursday, August 30, 2012
How you manage your health in earlier parts of your life will have an effect further down the line: "To examine the association between midlife fitness and chronic disease outcomes in later life, participant data from the Cooper Center Longitudinal Study were linked with Medicare claims. We studied 18,670 healthy participants (21.1% women; median age, 49 years) who survived to receive Medicare coverage from January 1, 1999, to December 31, 2009. Fitness estimated by Balke treadmill time was analyzed [according] to age- and sex-specific quintiles. Eight common chronic conditions were defined [and] associations between midlife fitness and the number of conditions were assessed. ... After 120,780 person-years of Medicare exposure with a median follow-up of 26 years, the highest quintile of fitness [was] associated with a lower incidence of chronic conditions [in men and women]. After multivariate adjustment, higher fitness [was] associated with a lower risk of developing chronic conditions in [men and women]. ... In this cohort of healthy middle-aged adults, fitness was significantly associated with a lower risk of developing chronic disease outcomes during 26 years of follow-up. These findings suggest that higher midlife fitness may be associated with the compression of morbidity in older age."
Thursday, August 30, 2012
A discussion on published results from this primate study suggest that both it and a comparison study are different in ways that make it harder to pull rigorous conclusions from the data - beyond the fact that diet clearly has influence, and the effects of calorie restriction on life span (average and maximum) are expected to be smaller in longer-lived species versus shorter-lived speces: "Scientists have found that calorie restriction - a diet composed of approximately 30 percent fewer calories but with the same nutrients of a standard diet - does not extend years of life or reduce age-related deaths in a 23-year study of rhesus monkeys. However, calorie restriction did extend certain aspects of health. ... The survival results in the study reported [by] NIA researchers differ from those published in 2009 by NIA-supported investigators at the University of Wisconsin-Madison. The Wisconsin study followed two groups of rhesus monkeys for 20 years and found that monkeys on a calorie-restricted diet lived longer than those on a standard diet. Beyond longevity, the parallel NIA and Wisconsin studies have reported similar beneficial health effects of calorie-restriction. Both studies found that certain age-related diseases - including diabetes, arthritis, diverticulosis and cardiovascular problems - occurred at an earlier age in monkeys on the standard diet compared to those on calorie restriction. However, this observation was not statistically significant in the NIA study. NIA researchers did find that monkeys started on calorie restriction at an early age had a statistically significant reduction in cancer incidence. NIA researchers also found that while calorie restriction had a beneficial effect on several measures of metabolic health and function in monkeys who were started on the special diet regimen during old age (at 16 to 23 years), it did not have the same positive outcome for monkeys started on calorie restriction at a young age (less than 14 years). In the Wisconsin study, all the monkeys were 7 to 14 years when started on calorie restriction. ... Differences in the monkeys' meal and other nutritional factors were cited as possible explanations for NIA's and Wisconsin's different outcomes. Both studies used a similar percentage of calorie restriction with their intervention groups; however, the Wisconsin monkeys in both the calorie restricted and control groups were eating more and weighed more than the matched NIA monkeys. ... NIA researchers cited genetics as another possible reason for their differing results. NIA monkeys had a greater genetic diversity, originating from China and India. Wisconsin's monkeys came only from an Indian colony."
Wednesday, August 29, 2012
A review paper: "Nutrition has important long-term consequences for health that are not only limited to the individual but can be passed on to the next generation. It can contribute to the development and progression of chronic diseases thus effecting life span. Caloric restriction (CR) can extend the average and maximum life span and delay the onset of age-associated changes in many organisms. CR elicits coordinated and adaptive stress responses at the cellular and whole-organism level by modulating epigenetic mechanisms (e.g., DNA methylation, posttranslational histone modifications), signaling pathways that regulate cell growth and aging (e.g., TOR, AMPK, p53, and FOXO), and cell-to-cell signaling molecules (e.g., adiponectin). The overall effect of these adaptive stress responses is an increased resistance to subsequent stress, thus delaying age-related changes and promoting longevity. In human, CR could delay many diseases associated with aging including cancer, diabetes, atherosclerosis, cardiovascular disease, and neurodegenerative diseases."
Wednesday, August 29, 2012
Some of the damage that occurs in brain injury is secondary to the initial trauma and takes place at the level of cellular components. Researchers here demonstrate a possible way to stop that from happening: "Treatment with an agent that blocks the oxidation of an important component of the mitochondrial membrane prevented the secondary damage of severe traumatic brain injury (TBI) and preserved function that would otherwise have been impaired. ... For the study, the research team conducted a global assessment of all the phospholipids in rat brain cells. This revealed that damage from TBI was nonrandom and mostly involved cardiolipin, a phospholipid that is found in the membranes that form mitochondria, the cell's powerhouse. They noted that in the healthy animal, only 10 of the 190 cardiolipin species were modified by oxygen, but after a brain injury, the number of oxidized species rose many-fold. The researchers then developed an agent, called XJB-5-131, which can cross the blood-brain barrier and prevent the oxidation of cardiolipin. Using an established research model of severe TBI, the agent or a placebo was injected into the bloodstream of rats five minutes and again 24 hours after head injury. In the weeks that followed, treated animals performed akin to normal on tests of balance, agility and motor coordination, learning, and object recognition, while placebo-treated animals showed significant impairment. The results indicate that blocking cardiolipin oxidation by XJB-5-131 protected the brain from cell death. ... a targeted oxidation-blocker might also be beneficial in the treatment of other neurological disorders, such as Parkinson's disease, amyotrophic lateral sclerosis, or ALS, and stroke."
Tuesday, August 28, 2012
A great deal of data is being generated on patterns of DNA methylation, aging, and variations in human longevity: "(1) we evaluated the DNA methylation from peripheral leukocytes of 21 female centenarians, their 21 female offspring, 21 offspring of both non-long-lived parents, and 21 young women ... (2) we compared the DNA methylation profiles of these populations ... We observed an age-related decrease in global DNA methylation and a delay of this process in centenarians' offspring. Interestingly, literature data suggest a link between the loss of DNA methylation observed during aging and the development of age-associated diseases. Genome-wide methylation analysis evidenced DNA methylation profiles specific for aging and longevity: (1) aging-associated DNA hypermethylation occurs predominantly in genes involved in the development of anatomical structures, organs, and multicellular organisms and in the regulation of transcription; (2) genes involved in nucleotide biosynthesis, metabolism, and control of signal transmission are differently methylated between centenarians' offspring and offspring of both non-long-lived parents, hypothesizing a role for these genes in human longevity. Our results suggest that a better preservation of DNA methylation status, a slower cell growing/metabolism, and a better control in signal transmission through epigenetic mechanisms may be involved in the process of human longevity. These data fit well with the observations related to the beneficial effects of mild hypothyroidism and insulin-like growth factor I system impairment on the modulation of human lifespan."
Tuesday, August 28, 2012
Cytomegalovirus (CMV) is a persistent and very common herpesvirus that is thought to be a major contributor to the age-related decline of the immune system, due to an ever increasing portion of its limited number of cells becoming specialized to CMV and thus unavailable for other duties. Various past studies have linked CMV with forms of age-related frailty, but here the researchers find an association with type 2 diabetes - which is interesting and perhaps somewhat unexpected, given that type 2 diabetes is essentially a lifestyle disease: "Cytomegalovirus (CMV) infection has been reported to contribute to the pathogenesis of type 1 diabetes and post-transplantation diabetes. However, CMV infection has not been evaluated as a possible risk factor for type 2 diabetes. Our aim was to investigate potential associations between CMV seropositivity, CMV IgG antibody level and glucose regulation in the oldest old. ... CMV seropositive subjects were more likely to have type 2 diabetes (17.2% vs 7.9%), had a higher level of HbA1c and higher non-fasting glucose in the oldest olds. These associations remained significant after adjustment for possible confounders. CMV IgG antibody level was not significantly associated with glucose regulation ... In the oldest old, CMV seropositivity is significantly associated with various indicators of glucose regulation. This finding suggests that CMV infection might be a risk factor for the development of type 2 diabetes in the elderly."
Monday, August 27, 2012
Here is an example to show that the urge to conform is somewhat stronger than the urge to live, and never mind the urge to think critically. People will tend to say that they want to be in the majority position now, no matter what that might be, and depending on how you phrase the question, the vast majority will tell you that they want to age to death and have a life that is no longer than that of their parents. Yet if longer lives were already common, those very same people would answer that they wanted to live those longer lives. It is frustrating, to say the least, the degree to which people live in the moment and blind themselves to what might be created: "How many years might be added to a life? A few longevity enthusiasts suggest a possible increase of decades. Most others believe in more modest gains. And when will they come? Are we a decade away? Twenty years? Fifty years? Even without a new high-tech 'fix' for aging, the United Nations estimates that life expectancy over the next century will approach 100 years for women in the developed world and over 90 years for women in the developing world. (Men lag behind by three or four years.) Whatever actually happens, this seems like a good time to ask a very basic question: How long do you want to live? Over the past three years I have posed this query to nearly 30,000 people at the start of talks and lectures on future trends in bioscience, taking an informal poll as a show of hands. To make it easier to tabulate responses I provided four possible answers: 80 years, currently the average life span in the West; 120 years, close to the maximum anyone has lived; 150 years, which would require a biotech breakthrough; and forever, which rejects the idea that life span has to have any limit at all. I made it clear that participants should not assume that science will come up with dramatic new anti-aging technologies, though people were free to imagine that breakthroughs might occur - or not. The results: some 60 percent opted for a life span of 80 years. Another 30 percent chose 120 years, and almost 10 percent chose 150 years. Less than 1 percent embraced the idea that people might avoid death altogether. These percentages have held up as I've spoken to people from many walks of life in libraries and bookstores; teenagers in high schools; physicians in medical centers; and investors and entrepreneurs at business conferences. I've popped the question at meetings of futurists and techno-optimists and gotten perhaps a doubling of people who want to live to 150 - less than I would have thought for these groups. Rarely, however, does anyone want to live forever, although abolishing disease and death from biological causes is a fervent hope for a small scattering of would-be immortals."
Monday, August 27, 2012
This is interesting, the early stirrings of something that may change the tenor of future tissue engineering if carried through to its logical conclusions. Why build a plain heart if you can build a sensor-laden heart with its own embedded network for monitoring and medical intervention? From the release: "A multi-institutional research team has developed a method for embedding networks of biocompatible nanoscale wires within engineered tissues. These networks - which mark the first time that electronics and tissue have been truly merged in 3D - allow direct tissue sensing and potentially stimulation, a potential boon for development of engineered tissues that incorporate capabilities for monitoring and stimulation, and of devices for screening new drugs. ... One of the major challenges in developing bioengineered tissues is creating systems to sense what is going on (e.g., chemically, electrically) within a tissue after it has been grown and/or implanted. Similarly, researchers have struggled to develop methods to directly stimulate engineered tissues and measure cellular reactions. ... In the body, the autonomic nervous system keeps track of pH, chemistry, oxygen and other factors, and triggers responses as needed. We need to be able to mimic the kind of intrinsic feedback loops the body has evolved in order to maintain fine control at the cellular and tissue level. ... With the autonomic nervous system as inspiration, [scientists] built mesh-like networks of nanoscale silicon wires - about 80 nm in diameter - shaped like flat planes or in a 'cotton-candy'-like reticular conformation. The networks were porous enough to allow the team to seed them with cells and encourage those cells to grow in 3D cultures. ... Previous efforts to create bioengineered sensing networks have focused on 2D layouts, where culture cells grow on top of electronic components, or on conformal layouts where probes are placed on tissue surfaces. It is desirable to have an accurate picture of cellular behavior within the 3D structure of a tissue, and it is also important to have nanoscale probes to avoid disruption of either cellular or tissue architecture."


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Three in serious condition after being thrown from SUV
Three people are in serious condition after they were ejected from their SUV, which drifted off Interstate 10 Sunday morning.
At about 11:30 a.m., the Chevy Tahoe of 23-year-old Kevin Billa of Charlotte, N.C., ran off the road in Jefferson County, according to the Florida Highway Patrol. The vehicle hit a guard rail, sending it back across the westbound lanes and into a stand of trees.
Billa, Edy Ramos-Andra, 26 of Fort Walton Beach, and Alwin Buesco-Cardona, 24, were all thrown from the vehicle.
None of them were wearing a seat belt.
Billa faces charges of fraud and driving without a license.
Read or Share this story: https://www.tallahassee.com/story/news/2018/08/13/three-serious-condition-after-being-thrown-suv/975024002/

subset: commoncrawl


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RobotWorx Celebrates 25 Years!
RobotWorx is so incredibly thrilled and grateful to be celebrating its 25th anniversary!
RobotWorx was created out of the genius (and garage!) of Keith Wanner. Keith had a fierce passion for robots and building things, so he did just that; he built a robotic company!
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Aritco Home Lift
Here at Morgan Ellis Lifts we are pleased to offer our completely bespoke and fully customisable Aritco Home Lift range. Every aspect of our exclsuive Home Lifts are fully customisable from the lift shaft to the carpet you walk on.
All of our Aritco Home Lifts are capable of up to an 15m vertical rise over as many as six floors. The customisable design of our Aritco Home Lifts are a perfect choice for any construction project and will enhance the value of your home.


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Product Description
It smells so good our customers want to eat it!
Nadia: "Such a fresh, beautiful soap!! I especially look forward to showers when this soap is waiting for me because the smell is just so yummy and it feels great and moisturising on the skin. I have to remind myself that tasting it would only ruin the experience." (Review)
Who for? Refreshes and moisturises mature, dry, oily and normal skin types. Especially good for hands and feet.
Our happy customers have come up with their own unique uses for this versatile soap:
Anna: "It smells fresh and zingy, lovely in hot weather. I order in bulk and keep them in my drawers to make my clothes smell nice until I'm ready to use them." (Review)
Sally: "This soap is fantastic! Both my boyfriend and I used this soap and it's left our skins wonderfully soft and scented. It's a unisex smelling soap so anyone can use it! I can't wait to try the other soaps." (Review)
What is it? A moisturising face and body soap that has the fresh herbaceous scent of mint from the Peppermint & Spearmint essential oils.
More information
Read about our Simple Pleasures Tasmanian herb and honey soaps


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Allegheny County is named for the Allegheny River.
Created: September 24, 1788
County Seat:
Pittsburgh 1788 – present
County Courthouse – Pittsburgh
Location: 415 Grant Street / 5th Avenue
Built: 1886 – 1888
Style: Richardsonian Romanesque
Architect: Henry Hobson Richardson
Contractor: Norcross Brothers and Booth and Flinn.
Description: The building faces west and is a four story brown colored stone structure. The building is built around an interior courtyard. A tower rises five stories from the courtyard's open side. The entire complex was built of large rusticated blocks of granite, with the entrance ways and windows topped with wide arches. The northwest and southwest corners have large square towers with steep roofs. The roof is steep with dormers placed at all the corners.
Note: The first courthouse was built in 1794. The second courthouse was designed by John Chislett and built in 1836 to 1841.
County Administration – Pittsburgh
Location: 415 Grant Street / 5th Avenue
Built: 1915 – 1917
Style: Neo-Classical
Architect: Henry Hornbosytel
Contractor: James L Stewart
Description: The building faces west and is a seven story gray colored stone and concrete structure. The building is built around an interior courtyard. The west front has three large arches rising to the third story. The main hall is surrounded by gilded classical columns 47 feet high, supporting a vaulted ceiling of Gustavino terra cotta tile. Architectural sculpture on the building was created by Charles Keck..On the seventh floor of the building is a massive mural completed in 1940 entitled "Justice" by award winning artist Harry Scheuch. The building is named as the City-County Building.
N – Butler County
W – Beaver County
Photos taken 2015


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Price drop on Westport superyacht Vango at Northrop & Johnson
by Malcolm MacLean
News just in from Kevin Merrigan and Wes Sanford at Northrop & Johnson of a $4,050,000 price cut on their listing for sale, the 50 metre motor yacht Vango.
Built in GRP by US superyacht yard Westport to ABS class and MCA compliant, Vango was launched in 2006 as the first in the yard's 164 series. A custom Donald Starkey interior is in mahogany wood and rich, upholstered fabric panels. She accommodates 12 guests in five staterooms plus 12 crew members. The VIP suite is on the bridge deck while the master suite and two large saloons are on the main deck. Below, there are a further three staterooms, a double and two twins, and all have entertainment systems and full en suite bathroom facilities.
Other features include a helicopter deck and an elevator, while twin 3,650 MTU engines give her a range of 5,000 nautical miles at 12 knots. Reportedly, the name Vango comes from the owner's keen admiration for Dutch artist Vincent Van Gogh.
Vango is now down from $24.5 million to $19,950,000.


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ADP panel+Pro v2 by Aaron Dowling
This is a very intuitive and easy to use panel. The look is very clean and it is divided in three different tabs. The first one is for creating and tweaking the muminosity masks. You can restrict or expand the masks and create selections you can then apply with a brush, instantly create curves layers and even create masks based on color range. The second tab is for adjusting precisely your selections and the third tab is to control some of the most used Photoshop functionalities.
I was pleasantly surprised by this panel, and I can highly recommend to users of all skill levels. The panel is not quite as powerful as the TK Panel, but it will make it for most of us photographers. Aaron is constantly making new excellent training material you can find on his website not only for Luminosity masking but also on how to use his panel as a basic work flow tool..
I have read on another website a great tip to make the panel work much fasteby, keeping the properties window closed. As the panel runs through a bunch of adjustment layers during mask creation, it has to refresh the properties window each time which slows it down massively.
The extension is built with 3 different panels. The first one id dedicated to the luminosity masks creation. Once you have selected wich tones or color you want to select, you get a preview of the masks and it creates three adjustment layers. A curves layer, a levels layer, and a black & white conversion layer you can adjust anyway you want.. It also provides one click actions to create all the adjustment layers, and in the last part another set of available selection tools.
The Auto Adjust panel is a very interesting one as you can work directly on Darks, Highlights ot contrast of the image by using sliders. It is a very easy and intuitive way to visualize what you are doing on the image. It is great when you begin as it it way more intuitive than using the luminosity masks that can be a little intimidating when you start..
Note that each panel provides some direct help and description of each function.
The thirs panel is for the finishing touch of your image. You have a fantastic detail extractor with a tonal range selection. Next you have some cool effects such as Soft Glow, the Orton effect and the Frequency separation very useful for both portraits and landscapes photographers.. And finally the resizing and sharpening tools, perfect for exporting to social medias.
This is the final image after
1. Basic processing in Lightroom to get a neutral balanced image.
2. Applying a luminosity mask to get a right midtones selection and getting a curves layer to build up the contrast.
3. Adding one more Camera Raw layer to further enhance the contrast.
This is a very fast and easy process made even easier by creating selections using the ADP Panel from Aaron Dowling..
You can get the Panel by visiting Aaron's website
Here is the image after the basic processing in Lightroom. I like to start with a neutral image that allows building up the light.
As the sky was very flat, I used a replacement sky. To place this new sky, I created a selection of the white sky, created a mak and placed the new one. I made a mistake as themask did not cover the bottom right part and I had to fix this by painting some white on the mask to reveal the missing part of the sky.
Then I clicked on "Create mask as curves" on the panel.
The next step was to draw a S curve to get the correct luminance for the shadows and highlights.
Final thoughts
Probably one of the best panels around.. I would say it comes on top alongside Greg Benz's Lumenzia for both performance and price considering that once you bought it, you get unlimited free updates. I need to mention that Aaron Dowling provides an excellent support if you need. He also provides quite a lot of tutorials.
He is already announcing the version 3 of this panel and it will provide a lot of improvments both in speed and functionality. For sure a 5 stars product.


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We all know chocolate is the food of the gods. The Mesoamerican ancients taught us this. And thank Quetzalcoatl they did because it's delicious. Especially raw. That's why I've been working on a raw truffle recipe so I can enjoy that rich, dark, bitter goodness in its unadulterated form. That and my toddler adores chocolate. While I'm not anti-candy in anyway (believe me–there are days I wake up and just want a handful of Sour Patch Kids for breakfast), I do like the idea of her eating raw homemade cacao treats with more frequency than anything manufactured by Cadbury. Below is my recipe. Please let me know what you think.
200 grams of pitted medjool dates
1/2 cup raw cacao powder (plus a little extra for dusting)
1/4 cup raw cacao nibs
1/4 cup toasted slivered almonds (save a few to top the truffles)
2 teaspoons maca powder
2 tablespoons shredded coconut (raw is fantastic but dessicated also works)
1 teaspoon vanilla bean paste
4 tablespoons light agave syrup
1 tablespoon coconut oil


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Dakota Ridge Real Estate - Steamboat
Search all Dakota Ridge homes for sale in Steamboat Springs, Colorado below. Located just on the other side of the Yampa river, homes in Dakota Ridge are only a short 5 minute drive to downtown or the ski mountain. The views driving around town and back to your home are only going to be rivaled by the views when you reach home. Home sites sit in locations with views of the South Valley, Downtown and the Mountain - giving you the perfect vantage point for watching beautiful early morning sunrises.
- Secluded Subdivision but only 2 miles from the base of the ski mountain
- Beautiful views of the Valley and Mountain
- Larger Home Lots ranging from 2.6-11.5 acres
Living in Dakota Ridge the home lots are much larger on average than other similar subdivisions around Steamboat. This extra space gives you the area to plant that garden you've always dreamed of or a place your kids to stretch their legs and play outside.
Properties For Sale in Dakota Ridge
Homes For Sale in Dakota Ridge Steamboat Springs
No listings were found matching your search criteria.
Terms and Conditions: The content relating to real estate for sale in this Web site comes in part from the Internet Data eXchange ("IDX") program of METROLIST, INC., DBA RECOLORADO® Real estate listings held by brokers other than The Steamboat Group are marked with the IDX Logo. This information is being provided for the consumers personal, non-commercial use and may not be used for any other purpose. All information subject to change and should be independently verified.
Copyright 2020 METROLIST, INC., DBA RECOLORADO® -- All Rights Reserved 6455 S. Yosemite St., Suite 500 Greenwood Village, CO 80111 USA
Listing information last updated on April 7th, 2020 at 7:46pm MDT.


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Thank you for visiting ExploreOrlandoFlorida.com!
Your online guide to everything pertaining to the Orlando lifestyle. If you would like to list your business on our website, please click here to contact us for advertising information.
Orlando Golf Tee Times
Book your tee times online and save money at local Orlando golf courses and country clubs in the central Florida region.
Click here for available tee times in Orlando.
Shopping in Orlando, Florida, Orlando Shops, Outlets, Outlet Malls in Orlando, Clothing Stores and Boutiques
Aside from the attractions, shopping is definitely the favorite past-time of visitors to Orlando! The main tourist areas have a staggering range of shops and stores. Here are a few suggestions when it comes to picking up a few bargains!
International Drive
Prime Outlets Mall is at the north end of International Drive. It's huge and easy to get lost, so keep checking where you are. An excellent selection of factory outlet stores offering good savings (check out the Disney Character Warehouse).
Festival Bay is also at the north end of International Drive with some good stores. Of note are the enormous Bass Pro outdoor shop and the ever-popular Ron Jon's Surf Shop.
Prime Outlets Designer Center bills itself as more upscale than the main Prime Outlets Mall. You'll find the likes of Donna Karan in residence.
Mercado Mediterranean Village is midway down International Drive. It's an eclectic collection of gift and curio shops to wander around and you can enjoy live entertainment in the evening.
Pointe Orlando is also midway down International Drive with shopping featuring designer stores and a huge FAO Schwarz toy store!
Orlando Premium Outlets is the newest addition to the Orlando outlet shopping scene and already wildly popular. Located off South International Drive.
Lake Buena Vista & DOWNTOWN DISNEY
Lake Buena Vista Factory Outlet is a very smart collection of name brand factory stores like Reebok, Gap Outlet, and Adidas. You'll find some good buys and it's easy to get around.
DOWNTOWN DISNEY Marketplace features acres of quality Disney Merchandise, much of which you won't find in the parks. The LEGO Imagination Center® has a great play area and the World of Disney is every Disney buff's dream come true!
DOWNTOWN DISNEY West Side sports a huge Virgin Megastore as the main focal point, along with specialty stores selling cigars, candy, and antique gas pumps!
Kissimmee (Hwy 192)
The Shops At Celebration in Disney's showcase community spend a lot of time trying to attract outside business. They are somewhat more upscale than most with a very pleasant waterfront setting.
Old Town is situated on Hwy 192 in Kissimmee. This collection of gift shops also offers amusements and thrill rides. Dads can seek relief from shopping at the 'Saturday Night Cruise' featuring all kinds of classic cars.
Kissimmee Manufacturers Mall is located on Hwy 192. This complex offers discount stores like London Fog and Nike.
Osceola Square Mall is closer to downtown Kissimmee and has 50 or so stores including Calvin Klein, Gap and Tommy Hilfiger.
Downtown Orlando
Fashion Square Mall is where the locals go to find good department stores, national chains and a good mix of everything else.
North Orange Avenue is where you'll find the city's biggest collection of antique and curio shops, just along from Lake Ivanhoe.
Altamonte Mall is located in Altamonte Springs. It's very popular with locals and offers an assortment of big department stores and smaller shops.
Seminole Towne Center is located 15 minutes north of Downtown Orlando. This relatively new mall is in Seminole County and is ideal to combine with a visit to historic Sanford.
Flea World is located on Hwy 17-92 in Sanford. It's a huge flea market that offers everything under the sun so be prepared to rummage!
Shops Of Note
Florida Mall is very popular with Europeans and conveniently located to Orlando International Airport at the junction of Sand Lake and Hwy 441. It features Saks 5th Ave.
West Oaks Mall is popular with visitors and locals alike. Iit's not as crowded as some shopping destinations and offers a good selection of stores.
Winter Park offers upscale shopping along Park Ave. It's not cheap, but this is as chic as it gets! It's definitely the in-place to window shop, promenade, and do lunch.
The Mall at Millenia features the biggest and ritziest names in department stores, specialty shops and restaurants for connoisseurs of fine shopping.
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Press releases:Thirrje për aplikime November 7, 2018Tirana Centre for Journalistic Excellence (TCJE), me mbështetjen e Ambasadës Amerikane në Shqipëri, po hap një thirrje për gazetarë të rinj në kuadër të projektit "Food Safety Investigation: can we trust what we eat?" ('Siguria Ushqimore: mund të kemi besim në çfarë hamë?')
Aplikantët e zgjedhur do mësojnë si të përpilojnë dhe të përgatisin raporte investigative mbi ...more This entry was posted in Njoftime, Notices by tcje10. Bookmark the permalink.TCJE: Series of lectures on human rights reporting launched February 26, 2014The Tirana Centre for Journalistic Excellence (TCJE) has launched a series of lectures on human rights journalism for representatives of the media and civil society.
The series, open to journalists and civil society representatives participating in TCJE's Reporting on Human Rights Project, includes lectures from experts in the field, human rights activists and experienced journalists that ...more This entry was posted in Notices by TCJE. Bookmark the permalink.TCJE.org launches elections platform May 22, 2013New bilingual media platform to offer English and Albanian election coverage
The Tirana Centre for Journalistic Excellence, a nonprofit organization, officially launched its elections coverage program on May 22 at an event with the participation of representatives from the country's international community, media and civil society.
TCJE.org's program, Providing Bias-Free Media Coverage During the 2013 Elections in ...more This entry was posted in Njoftime, Notices and tagged Press Releases by TCJE. Bookmark the permalink.


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Sold Out
The Rockschool Ukulele syllabus is an ideal introduction to developing stringed instrument technique in a contemporary music setting, whilst introducing students to Rockschool's world renowned range of stylistically appropriate and relevant supporting tests. Each grade includes full ensemble backing tracks and duet arrangements, providing students with the opportunity to perform as both accompanists and soloists.
Rockschool Ukulele Grade 1 course will take reference from the Rockschool Ukulele Grade 1 book which contains everything you need to pass your exam. Featuring a truly diverse range of contemporary repertoire from some of the world's most iconic artists, including Adele, Radiohead and Cat Stevens. Play along to a backing track either on lead on rhythm or play in a band setting if you are in a group class.
Suitable for:
Fees & Format:
All classes will be held at Upstairs by UM (2, Kitchener Road, #02-87, Singapore 200002) unless stated otherwise.
Upstairs by UM Google map here.
The huge array of ever-evolving styles in contemporary music can often seem as daunting as it is appealing. The Ukulele syllabus is a perfect introduction to popular songwriting and composition in a variety of styles and genres
Featuring repertoire from artists such as Taylor Swift, Adele, Pharrell Williams, Bob Dylan, U2, David Bowie, Bill Withers, The Who, Pearl Jam, Radiohead, Coldplay, The Killers, Biffy Clyro, Bruno Mars, Jess Glynne, Jason Mraz, George Ezra and James Bay
The Ukulele syllabus incorporates duet arrangements, at every grade, that allow each candidate to perform in a duet or ensemble setting, either with their teacher or fellow students
The professionally produced accompanying audio at each grade features performances from renowned session musicians and a guest appearance at Grade 3 from global rock star, Ryan Fletcher from the UK band Lawson.
In addition to the 6 pieces on offer in each of our Grade Books, you are also able to choose two Free Choice Pieces. Learn more
Instantly download your Ukulele book, individual tracks or supporting tests. The RSL shop allows student and instructor to use their favourite Rockschool titles on their desktop, tablet or smartphone.


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In 2009 we described an outbreak caused by extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli in southern Sweden that occurred during 2005–2006. An important finding from the investigation was the long carriage times of the ESBL-producing E. coli in several of the patients, which in some cases exceeded 30 months. Here we report findings from the continued follow-up of bacterial carriage. In September 2010, 5 of the 42 patients still carried the bacteria after a median of 58 months (range 41–59 months), 18 had had repeatedly negative cultures after shedding bacteria for a median of 7.5 months (range 0–39 months), 16 had died while still shedding the bacteria for a median of 9 months (range 0–38 months), and 3 had been lost to follow-up.
During the fall of 2005 and the spring of 2006, there was a nosocomial infection outbreak caused by a multiresistant Escherichia coli producing Extended-Spectrum Beta-Lactamase (ESBL) in a unit at the Central Hospital in Kristianstad. The bacteria were believed to be transmitted through patient contact with the hands of staff members. Since five of the cases of ESBL-producing E. coli were found in wounds of patients from the unit, wounds in other units needed to analyzed. In Sweden, patients with wounds are treated in hospitals as well as in municipal health care settings. The aim of this study was to investigate, improve and evaluate hygiene routines among the hospitals' and municipal health care facilities' staff members. In addition, a screening for the microbial flora, including multi antibiotic resistance, in patients' wounds in these facilities was carried out.
The study used a cross-sectional pre- and postintervention design. The data collection was designed as naturalistic observational study with participant observations and interviews. The study was performed at two central general hospitals, three general hospitals and six counties municipal health care settings in Sweden. The coverage area were 370 000 inhabitants. The data from the investigation in 2006 were analyzed and presented in individually written reports for each unit. The national regulations on basic hygiene were implemented in 2007. A poster was distributed to all participating units and displayed for patients and visitors. The message of the poster stated: "[We respect patient hygiene safety by: wearing short sleeves; long hair wearing up; have short unpainted nails; not wearing jewellery on our hands or arms; disinfect our hands before and after every patient and care procedure. Please remind us if we forget!]". In 2006, 214 units, 2541 staff members in a patient care situation and 218 staff members were observed when treating wounds. In 2008, 221 units, 2339 staff members in a patient care situation and 142 staff members were observed when treating wounds.
The working clothes provided by the employer significantly increased for municipal staff members (from 39% to 62%) as did the use of plastic aprons also (from 53% to 75%). Staff members with either short hair or long hair wearing it up was significantly decreased for municipality staff members (from 94% to 88%). The correct absence of jewellery increased significantly (from 53% to 69%), as did the correct absence of nail polish, build up nails, and infected cuticles (from 74% to 77%)). The use of gloves increased significantly for all staff members (from 83% to 89%). The staff members were observed during a wound treatment situation, and the correct absence of jewellery increased for hospital staff members (from 75% to 89%). The use of gloves decreased (from 91% to 80%). The use of plastic apron significantly increased (from 27% to 52%). In the microbiology screening study, a total of 394 patients with 438 wounds were included. The most frequent microbe was Gram-positive cocci, which was found in 458 (60%) of the 760 isolates and in 353 (81%) of the wounds. Two ESBL-producing isolates were found, one Escherichia coli and one Enterobacter aerogenes.
The findings suggest that the combined interventions and the method used with multidisciplinary teams as well as multiple strategies for interventions might have a positive effect on focusing on hygiene routines. Knowledge of the local bacteria flora and their antibiotic resistance as well as the type of wounds, is of importance when deci ing what antimicrobial treatment to suggest, and the monitoring needs to be continuing.


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Three wishes
- 23 May 2019 at 11:03
Photo courtesy of Walt Disney (Thailand)
"Get audio & vocabulary bubbles for this article, touch here."
Aladdin is back in an exciting new movie
The streets of Agrabah are home to Aladdin (Mena Massoud), a lovable street kid who wants to leave his life of crime behind. Across town, the Sultan's daughter, Princess Jasmine (Naomi Scott), has dreams of her own. She dreams of experiencing life beyond the palace walls and help the people of Agrabah, but her father is very protective. The Sultan wants to choose a husband for his daughter, while Jafar, his advisor and a powerful sorcerer, is frustrated with the Sultan's ideas on Agrabah's future and is devising a plan to take the throne himself.
Aladdin comes to Jasmine's rescue when she visits the market. Following her back to the palace, he gets caught up in Jafar's evil scheme and comes into possession of a magic oil lamp intended for Jafar and accidentally conjures up the Genie (Will Smith) inside. The Genie grants Aladdin's wish to become Prince Ali, so he can make the princess fall in love with him. Aladdin, the Genie and Jasmine start a dangerous and exciting adventure that will test their faith in themselves and their love for one another.
Aladdin is at a cinema near you now.


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Medellín, Colombia, calle vectorial imprimible mapa Plan de la ciudad, lleno, Adobe Illustrator editable, vector completo, y editables, nombres de calles de formato de texto, escalables, 3,6 mb ZIP
Todas las calles, algunos edificios más. Mapa de diseño, impresión, artes, proyectos, presentaciones, para los arquitectos, diseñadores y constructores.
PDF, DXF, DWG, CDR y otros formatos – a petición, el mismo precio, por favor, póngase en contacto
Medellin, Colombia, printable vector street City Plan map, full editable, Adobe illustrator, full vector, scalable, editable, text format street names, 3,6 mb ZIP
All streets, some more buildings. Map for design, print, arts, projects, presentations,
for architects, designers and builders.
PDF, DXF, DWG, CDR and other formats – on request, same price, please, contact
Medellin, Colombia.
This vector map of Medellin is used as a basis for design, editing, and further printing.
This is the most detailed, exact map of Medellin for high-quality printing and polygraphy. You can always clarify the map development date by contacting us.
For your convenience, all objects on Medellin vector map are divided into layers. And the editing is very easy – colors, lines, etc.
You can easily add any objects needed (e.g. shops, salons, sale points, gas station or attraction) on any layer of Medellin vector map.
Medellín is the second-largest city in Colombia and the capital of the department of Antioquia. It is located in the Aburrá Valley, a central region of the Andes Mountains in South America. According to the National Administrative Department of Statistics, the city has an estimated population of 2.5 million as of 2017. With its surrounding area that includes nine other cities, the metropolitan area of Medellín is the second-largest urban agglomeration in Colombia in terms of population and economy, with more than 3.7 million people.
One of the advantages of Medellin vector maps of our production is the relevance of cartographic data, we constantly update all our products.
This vector map of Medellin is used by:
designers, layout designers, printers, advertisers and architects. Our product – vector maps – is designed for further editing and printing in large formats – from @Wall format (a few meters) to A-0 and A-1, A-2, A-3.
Medellin map in vector format is used for design, urban planning, presentations and media visualizations.
Advertising and presentation map of Medellin (usually the final designer marks the routes, and puts the client's objects (shops, saloons, gas stations etc.)
The undoubted advantage is that people will NEVER throw out this advertising product – the map. In fact, as an advertising medium, a map is the most "long-playing" of the well-known polygraphic advertising media, with the longest lifespan, and the maximum number of interactions with the customer.
For travelers, maps are sold at the airports and gas stations around the world. Often the source is our vector maps.
Take a look, who purchases our vector maps of Medellin in "Our Clients and Friends" page – these are large and small companies, from super-brands like Volvo and Starbucks, to small design studios and printing houses.
It's very easy to work with vector maps of Medellin, even for a not very experienced designer who can turn on and off the map layers, add new objects, change the colors of fill and lines according to customer requirements.
The undoubted advantage of Medellin vector maps in printing is an excellent and detailed visualization, when customer can expand a large paper map and instantly define his location, find a landmark, an object or address on map, unlike using the popular electronic formats of Google and Yandex maps for example.
Printable vector maps of Medellin are much more convenient and efficient than any electronic maps on your smartphone, because ALL DETAILS are displayed in the entire space of Medellin map.
Useful tips on working with vector maps of cities and countries in Adobe Illustrator.
«V» – launches the Selection tool (cursor, black arrow), which makes active any vector line.
«А» – launches the Direct Selection tool (white cursor), allows you to select curve elements and drag them to the desired place.
«R» – activates the Rotate tool, which helps you rotating selected objects around the center point by 360 degrees.
«E» – gives you the opportunity to use the Eraser tool and erase unnecessary parts.
«X» – switches between Fill and Stroke in the Tools section. Try to get used to this hot key and
you will quickly understand that you can't live and work without it.
Guides are not limited to vertical and horizontal in Adobe Illustrator. You can also create a diagonal guide for example. Moreover, you can turn any contours into guides. Select the outline and go to View > Guides > Make Guides (Create Guides), or simply press Cmd/Ctrl + 5. You can also turn the guides back into an editable object. Go to menu, View > Guides > Unlock Guides (Release Guides), select the guide you want to edit and select View > Guides > Release Guides (Reset Guides), or just press Cmd/Ctrl + Option / Alt + 5).
You will probably want to change the color scheme used on our Medellin vector map.
To quickly and effectively play with colors.
Of course, you can do it manually, all objects in our Medellin vector map are divided according to types and layers, and you can easily change the color gamma of vector objects in groups and layers.
But there is more effective way of working with the whole VECTOR MAP of Medellin and all layers:
The overview dialog «Edit colors»/«Repaint Graphic Object» (this dialog box name can change depending on the context):
If you have selected a part or a layer of Medellin vector map and open the dialog box by clicking the icon in the Control panel, on the Samples palette or the Color Catalog, or if you choose Edit > Edit Colors> Repaint Graphic Object, then the «Repaint Graphic Object» dialog box appears, and you get access to «Assign» and «Edit» tabs.
If a picture or a map fragment is not selected, and you open the dialog box by clicking the icon in the Control panel, on the Samples palette or in the Color Catalog, the «Edit Colors» dialog box appears and you can only access the «Edit» tab.
Regardless of the name at the top of the dialog box, the right-hand side always displays the color group of the current document, as well as two default color groups: Print Color and Grayscale. These color groups can be selected and used any time.
In 1616 the Spaniard Francisco Herrera Campuzano erected a small indigenous village ("poblado") known as "Saint Lawrence of Aburrá" (San Lorenzo de Aburrá), located in the present-day El Poblado commune. On 2 November 1675, the queen consort Mariana of Austria founded the "Town of Our Lady of Candelaria of Medellín" (Villa de Nuestra Señora de la Candelaria de Medellín) in the Aná region, which today corresponds to the center of the city (east-central zone) and first describes the region as "Medellín". In 1826, the city was named the capital of the Department of Antioquia by the National Congress of the nascent Republic of Gran Colombia, comprised by present-day Colombia, Venezuela, Ecuador and Panama. After Colombia won its independence from Spain, Medellín became the capital of the Federal State of Antioquia until 1888, with the proclamation of the Colombian Constitution of 1886. During the 19th century, Medellín was a dynamic commercial center, first exporting gold, then producing and exporting coffee.
Create and edit color groups of Medellin vector map, and also assign colors using the «Edit Colors»/ а «Repaint Graphic Object» dialog box.
A. Creating and editing of a color group on the «Edit» tab
B. Assigning colors on the «Assign» tab
C. Select a group of colors from the «Color groups» list
The option «Repaint a graphic object» in the lower part of the dialog box allows you to preview the colors on a selected layer of Vector map, or a group of elements, and specify whether its colors will be redefined when the dialog box is closed.
The main areas of the dialog box are:
The «Edit» tab is designed to create a new or edit the existing color groups.
The harmony rules Menu and the Color Wheel are used to conduct experiments with color harmonies. The color wheel shows how colors are related in color harmony, and the color bars allow you to view and manipulate an individual color values. In addition, you can adjust the brightness, add and remove colors, save color groups and view colors on the selected Vector Map of Medellin or a separated layers.
The «Assign» tab is used to view and control on how the original colors are replaced with colors from the color group like your corporate colors in the Vector Map of Medellin.
The assign color ability is provided only if the entire map, layer or fragment is selected in the document. You can specify which of new colors replace the current colors, whether the spot colors should be preserved and how colors are replaced (for example, you can replace colors completely or changing the color tone while maintaining the brightness). The «Assign» tab allows you to redefine colors in the Vector Map of Medellin, or in separate layers and fragments using the current color group or reducing the number of colors in the current Vector Map.
Color groups
Is a list of all saved color groups for current document (the same groups appear in the «Samples» palette). You can edit and delete the existing color groups, as well as creating a new ones using the list of "Color Groups" in the dialog box. All changes appear in the «Samples» palette.
The highlighted color group shows, which color group is currently edited.
Any color group can be selected and edited, or used to redefine the colors in the selected vector map of Medellin, its fragments or elements.
Saving a color group adds this group to the specified list.
Opening the «Edit Colors»/«Repaint Graphic Object» dialog box.
Open the «Edit Colors»/«Repaint Graphic Object» dialog box using one of the following methods:
«Edit»> «Edit Colors»> «Repaint Graphic object» or «Repaint With Style».
Use these commands if you need to edit the colors in the selected vector map of Medellin.
«Repaint Graphic object» button on the «Control» panel.
Use this button if you need to adjust colors of Medellin vector map using the а «Repaint graphic object» dialog box.
The specified button is available if the selected vector map or its fragment contains two or more colors.
Note. This color editing method is convenient for global color adjustment in a vector map, if global colors were not used when creating a Map of Medellin.
The «Edit colors» button or «Edit or apply colors» on the «Color Catalog» palette
Click this button if you need to edit colors on the «Color Catalog» palette or edit and then apply them to the selected Vector Map of Medellin or its fragment.
The «Edit color group» button or «Edit or apply color group» on the «Samples» palette.
Click this button if you need to edit the colors in the specific color group or edit and apply them to the selected Vector Map of Medellin or a group of its elements, for example, the whole layer "Streets and lines". You can also double-click the color group in the Samples panel to open the dialog box.
If the map file is too large and your computer freezes or even can't open it quickly:
1. Try to reduce the color resolution of the video card (display) to 256 colors while working with a large map.
2. Using Windows Task Manager, select all the application you don't need, while working with map, just turn them off.
3. Launch Adobe Illustrator. (DO NOT OPEN the vector map file)
4. Start the Windows Task Manager using administrator rights > Find the "Illustrator" process > set the «real time» priority,
5. Open the file. When you see the LEGACY FONT popup window – click "OK" (do not update). You can restore the TEXT later.
6. Can also be useful: When file is opened – Edit > Settings > Basic Settings > disable smoothing. /// It looks scary, but works quickly)))
We recommend saving the file in Adobe Illustrator 10 version. It's much more stable when working with VERY BIG size files.
At the beginning of the 21st century the city regained industrial dynamism, with the construction of the Medellín Metro commuter rail, liberalized development policies, improved security and improved education. Researchers at the Overseas Development Institute have lauded the city as a pioneer of a post-Washington consensus "local development state" model of economic development. The city is promoted internationally as a tourist destination and is considered a global city type "Gamma -" by GaWC.
The Medellín Metropolitan Area produces 67% of the Department of Antioquia's GDP and 11% of the economy of Colombia. Medellín is important to the region for its universities, academies, commerce, industry, science, health services, flower-growing and festivals.
In February 2013, the Urban Land Institute chose Medellín as the most innovative city in the world due to its recent advances in politics, education and social development. In the same year, Medellín won the Verónica Rudge Urbanism Award conferred by Harvard University to the Urban Development Enterprise, mainly due to the North-Western Integral Development Project in the city. In September 2013, the United Nations ratified Colombia's petition to host UN-Habitat's 7th World Urban Forum in Medellín, from April 5–11, 2014.
Medellín won the Lee Kuan Yew World City Prize 2016. The award seeks to recognize and celebrate efforts in furthering innovation in urban solutions and sustainable urban development.
Medellín has 16 comunas (districts), 5 corregimientos (townships), and 271 barrios (neighborhoods). The metropolitan area of Medellín lies within the Aburrá valley at an elevation of 1,500 metres (4,900 feet) above sea level and is bisected by the Medellín River (also called Porce), which flows northward. North of the valley are the towns of Bello, Copacabana, Girardota and Barbosa. To the south of the valley lie Itagüí, Envigado, Sabaneta, La Estrella and Caldas.
Small guide: How to work with the vector map?
You can: Mass select objects by type and color – for example, the objects type "building" (they are usually dark gray) – and remove them from the map, if you do not need them in your print or design project. You can also easily change the thickness of lines (streets), just bulk selection the road by the line color.
The streets are separated by type, for example, type "residential road" are usually white with a gray stroke. Highway usually orange with a brown or dark gray stroke.
It is easy to change the font of inscriptions, all or each individually. Also, just can be make and any other manipulation of objects on the vector map in Adobe illustrator format.
Important: All the proportions on the map are true, that is, the relative sizes of the objects are true, because Map is based on an accurate GPS projection, and It transated into the (usual for all) the Mercator projection.
You can easily change the color, stroke and fill of any object on the map, zoom without loss of quality Image Verification.
Select object
Bulk selection the same objects on the vector map
See the bulk selected objects on the vector map
Bulk delete buildungs from the vector map
Select residencial road (small street) on the vector map
Bulk selection the same lines (streets, roads) on the full map
Create fat lines of the streets on the vector maps (bulk action) 1
Create fat lines of the streets on the vector maps (bulk action) 2
Create fat lines of the streets on the vector maps (bulk action) 3
You can easily change the color, stroke and fill of any object on the map, zoom without loss of quality Image Verification.
Tips/Tricks/Tutorials & News about vector maps.
Tangram Patterns is an eye dazzling demonstration of a Tangram vector map incorporating patterns from texture.js.
Mapzen's Tangram mapping platform is a library for creating 2D & 3D maps using WebGL. Tangram Patterns uses Textures.js, a d3.js based library for creating SVG patterns, with the Tagram map library. The SVG patterns created by Textures.js are designed to be used in data visualizations.
The effect isn't exactly easy on the eyes when you apply so many of the textures on one map like this. Hopefully if you ever create a mapped visualization of your data using Textures.js you will be a little more selective in the choice and number of patterns.
A number of other great experimental maps have been created with Tangram. This Day / Night Map shows how colors and building footprints can be updated in real-time in the browser. The Tron Map shows how you can apply animation to map tiles (in this case to create the effect of moving vehicles on roads and streets).
My favorite style so far is this Cross Hatch map (pictured). I'm also rather fond of the Lego Style map,
made out of colored plastic brick textures. When panning around on
these maps notice how the perspective on the 3d buildings changes with your point of view. Source.
See more Vector city Maps here.


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There are many factors that can alter the way you attack your day. The best way to set up your chances for success is to make sure that you are charged, rested, and refreshed. This way you will have the appropriate amount of energy to head towards your dreams! Getting out of bed in the right mood and mentality is the first step! If you are looking to have productive energy throughout the day, read this article today to learn how your bedroom can inspire your energy!
Read the full article here: Transform Your Bedroom to Make It Easier to Wake Up Early


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Cellular app development is a excessive grossing industry as we speak and due to this fact most software designers engage within the creation of apps for mobile devices and platforms. The creator holds a content material writer position with an enterprise apps improvement firms that provides mobility solutions with its highly devoted crew of iPhone developer Dallas Texas The one and cross platform app development firms Dallas is best identified for the highly innovation options and its inexpensive utility development cost. For the remainder of this blog, some tips for choosing and utilizing a Mobile Utility Improvement Platform are offered. In his role of Enterprise Head at Techugo, a top cellular app development company in India , Ankit affords a helping hand to those, who need to construct apps. He dedicates his passion in committing the vision of clients and purpose of the mission simultaneously and he loves to share his writing abilities by means of weblog and article writing.
Pockets by ICICI Financial institution is a singular 'Digital Financial institution'. Its first providing is a pockets – a digital place to retailer your money and use it for varied transactions like cell recharge, ship money, ship gifts, pay bills and lots of extra. What's extra, the cool user app interface will be personalised as you like and it helps you to transact in a snap. Moreover, there is also an option of getting a zero balance financial savings account. and customers get to strive more than 100 providers making it a must have mobile banking app.
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Buyer perceptions are subjective assessments of precise service experiences; customer expectations are the standards of, or reference factors for, performance against which service experiences are in contrast. The sources of buyer expectations encompass market-controlled components, reminiscent of advertising, as well as elements that the marketer has limited means to affect, akin to innate private needs. Ideally, expectations and perceptions are an identical: prospects understand that they suppose they are going to and should. In observe, a buyer hole sometimes exists. Good marketing methods reduces this gap.


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Hartelijk welkom
"But I suppose it's often that way. The brave things in the old tales and songs, Mr. Frodo: adventures, as I used to call them. I used to think that they were things the wonderful folk of the stories went out and looked for, because they wanted them, because they were exciting and life was a bit dull, a kind of a sport, as you might say. But that's not the way of it with the tales that really mattered, or the ones that stay in the mind."
–Samwise Gamgee, The Two Towers
Darkest Night, by designer Jeremy Lennert, is a fully-cooperative board game for up to four players, set in a kingdom broken under a Necromancer's shadow. Each player takes on the role of one of the kingdom's last heroes, each with a unique set of special abilities, just as they hatch a plan to save the realm.
"...I saw the world battling against blackness; against the waves of destruction from ultimate space; whirling, churning; struggling around the dimming, cooling sun. Then the sparks played amazingly around the heads of the spectators, and hair stood up on end whilst shadows more grotesque than I can tell came out and squatted on the heads."
–H.P. Lovecraft, Nyarlathotep
Can you infect the world? In the strategic board game Plague Inc, 1-4 players evolve deadly plagues and battle to be first to wipe out humanity!
"Assuming that I was sane and awake, my experience on that night was such as has befallen no man before. It was, moreover, a frightful confirmation of all I had sought to dismiss as myth and dream."
–H. P. Lovecraft, The Shadow Out of Time


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Expanding Horizons at the Survey Ireland Conference 2016
Murphy Surveys will be exhibiting at this year's Survey Ireland Conference. This year's conference looks to explore the theme of 'Expanding Horizons' and Murphy Surveys is set to do just that as we prepare to introduce those in attendance to our new MurphyUAV division.
We will have our Falcon 8 UAV [Unmanned Aerial Vehicle] on display at our stand with Director of MurphyUAV, Julian Deeks, on hand to answer any questions and to introduce the capabilities of the new division and our reasons for implementing this innovative technology.
The Survey Ireland Conference takes place Thursday, May 19th at the Red Cow Hotel, Dublin 22. According to the SCSI, the title of 'Expanding Horizons' reflects an invigorated Geomatics profession in Ireland now represented by a single professional body. The programme has been designed to offer insight from geospatial information providers, and stakeholders, under a range of themes reflecting the breadth of modern Geomatics activity.
Make sure you come along and visit Murphy Surveys at our exhibition stand, 8 & 9, this Thursday. You can Register to Attend via SCSI.
For any enquiries, you can contact us today:
t. 045 484 040


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May 22, 2018
In this podcast, recorded live at Figure Eight's TRAIN AI 2018 conference in San Francisco, Garry Kasparov and Sam Charrington of This Week in Machine Learning (TWiML) discuss Garry's bouts with chess-playing computer Deep Blue–which became the first computer system to defeat a reigning world champion in their 1997 rematch–and how that experience has helped shape his thinking on artificially intelligent systems. They also explore Garry's perspective on the evolution of AI, the ways in which chess and Deep Blue differ from Go and Alpha Go, and the significance of DeepMind's Alpha Go Zero. They also talk through his views on the relationship between humans and machines, and how he expects it to change over time.


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Rebecca Catching
Fudan University, 2001, Chinese language
Art, music, film, dance, theatre, cultural trends in China and Middle Eastern art
Editor, freelance writer, copy editor, art critic and lecturer based in China and the Middle East
Deputy Features Editor Oct 2008-Feb 2008
The National (www.thenational.ae) Abu Dhabi, UAE
• commissioned, edited and proofed the 45-page arts & life section of an English broadsheet in Abu Dhabi, with a circulation of 70,000
Deputy Editor June 2008-Sept 2008
that's Shanghai (www.urbanatomy.com) Shanghai, China
•subbed articles, managed production and ran the arts & entertainment section
Arts and Entertainment Editor November 2003-May 2008
that's Shanghai (www.urbanatomy.com) Shanghai, China
• managed a 20-page arts and entertainment section in Shanghai's premiere
English language monthly ¬- a lifestyle magazine modeled on Time Out with in-depth arts coverage and a circulation of 62,000
• wrote 5-7 articles a month, sourced all images and managed an internship program.
Shanghai Correspondent
Art Asia Pacific
• contributed regular articles October 2006-May 2008
Shanghai, China
Shanghai Correspondent
Billboard Magazine
• contributed articles and reporting to Billboard October 2007-January 2008 Shanghai, China
Consultant Editor March 2007-August 2007
Time Out Guide: Shanghai Shanghai, China
• subbed copy, fact checked articles and provided additional research
• contributed to Galleries, Performing Arts, Festivals and regional sections of the guide
Freelance Writer November 2004-present
Shanghai, China
The Guardian (UK), The Far Eastern Economic Review (Hong Kong), Newsweek (Chinese edition), Swindle (LA), BudgetTravel (NY), South China Morning Post (Hong Kong), H&M Magazine (Sweden), Vice Magazine (NY) and Rodeo Magazine (Sweden)
• contributed articles on the Chinese art market, innovation in China and India, Live Earth Shanghai, mass production in Chinese art, Chinese designers, the Shanghai Concert Hall and Shanghai's cutting edge design and urban culture.
Art Critic November 2004-present
Shanghai, China
•contributes reviews and news pieces for Flash Art, Art Review and Broadsheet (Australian art magazine)
• Speaker: gave talks at Creek Art and 1918 Space (Shanghai-based galleries) and has participated in conferences: "URBAN CHANGE: Urban Transformation in Twenty-first Century China" held by the Architectural Association's Architecture School in London and "Under Construction: strategies-models-links" at Shanghai's Zendai Museum
• gives tours to tourists and art professionals visiting Shanghai
Deputy Editor November 2003-2004
Metrozine (monthly lifestyle magazine) Shanghai, China
• wrote features, reviews, took photos, copy-edited and proofread
Vice Magazine (Urban culture magazine) August 1997 - April 1999
• responsible for streeters and portraits Montreal, Canada
Chinese Language Major (Economics class) September 2001-July 2002
Fudan University, International Cultural Exchange School Shanghai, China
Bachelor of Arts
McGill University 1996 - 2001
Concentration: Art History and East Asian Studies Montreal, Canada
• Canada China Scholarship: a full-year, all-expenses-paid scholarship to study in China in 2001
• second place in 2001 Montreal Chinese Language Speech Contest
English (Fluent spoken and written), French (fluent spoken, intermediate written) and Mandarin (fluent spoken, intermediate written)
• 2007-2008 Media Representative of the Shanghai Foreign Correspondents Club (organizer and moderator)
• Interests: Chinese cooking, cinema and Indian literature
• Founder of a volunteer English teaching program for underprivileged children in Shanghai
• Has traveled extensively in China and has visited other destinations in Asia, the Indian Subcontinent and the Middle East
The website will be permanently closed shortly, so please retrieve any content you wish to save.


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"Show Me Where To Walk" Photo by Judy Royal Glenn
Click on the photo for a closer view!
I loved watching this Marbled Godwit walk on the beach. This photo was taken a long time ago, but I think I took it on St. Simons Island, Georgia.
"Let me hear of your unfailing love each morning, for I am trusting you. Show me where to walk, for I give myself to you." (NLT, Psalm 143.8)


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One of the things that is most admired about Volvos – and a primary reason why consumers flock to them – is that they are incredibly well built. Volvos withstand the daily wear and tear of driving far better than the average vehicle, which is hugely beneficial for two reasons: it allows them to have a longer life, and it drastically decreases the frequency and cost of auto repairs.
But, as impressive as Volvos are when it comes to being built to last, they are not invincible. No... read more
Few cars have undergone the transformation that the station wagon has. The sports car has always been the sports car, built for those who love the pleasure of driving; the minivan has always been the minivan, built for those with families in need of space for traveling; and the truck has always been the truck, built for those who need its hauling capabilities.
But perceptions of the station wagon have changed over the years. And no car company has embodied the station wagon – an... read more
A BMW is a much sought after automobile because of its sheer performance, supreme luxury, extreme reliability, smooth handling, and a fine example of German engineering. Under the circumstances it needs state-of-the-art repair and service. And if you happen to own a BMW and live in or around Chilliwack, there are indeed a few such BMW Repair Shops, for your convenience, and Collins Automotive is one of them. Our repair service stands ready to serve all BMW owners hailing from... read more
The Mercedes-Benz car has long been known for its safety, quality engineering and durability. However, the Mercedes-Benz car requires a lot of upkeep. For example, the repair costs or the cost of replacing parts is very high. Typically, Mercedes-Benz mechanics have lengthy wait lists. Thus, if you have a Mercedes-Benz car, it is in your best interest to learn how to keep the car in good condition so that it can last for many years. The following are six things that can be done to facilita... read more
So you just bought a new Subaru vehicle, but do you know how to keep up with the maintenance? Subaru's are some of the best vehicles on the planet and can give you many years of quality driving experience. You need to ensure that your vehicle is on the road for as long as possible so that you can get the most out of your investment. At Collins Auto we will be there for you to help ensure that the maintenance on your vehicle is handled properly. From oil changes to keeping up with the fluid... read more