text: Tuesday, November 06, 2012 New York Chapter Relief Fund Information Now Online As reported Friday in News Now, the New York and New Jersey chapters have set up relief funds for the physical therapy community affected by Hurricane Sandy, with APTA matching contributions up to $5,000. The New York Chapter's donation page now is live on the chapter's website. The New Jersey Chapter's donation page can be found at the chapter's website.


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The preproduction Intel Xeon Phi coprocessors based on the Knights Corner (KNC) chips can provide well over one teraflop of floating-point performance. Developers can reach this supercomputing level of number crunching power via one of several routes:
- Using pragmas to augment existing codes so they offload work from the host processor to the Intel Xeon Phi coprocessors(s)
- Recompiling source code to run directly on coprocessor as a separate many-core Linux SMP compute node
- Accessing the coprocessor as an accelerator through optimized libraries such as the Intel MKL (Math Kernel Library)
- Using each coprocessor as a node in an MPI cluster or, alternatively, as a device containing a cluster of MPI nodes.
From this list, experienced programmers will recognize that the Phi coprocessors support the full gamut of modern and legacy programming models. Most developers will quickly find that they can program the Phi in much the same manner that they program existing x86 systems. The challenge lies in expressing sufficient parallelism and vector capability to achieve high floating-point performance, as the Intel Xeon Phi coprocessors provide more than an order of magnitude increase in core count over the current generation quad-core processors. Massive vector parallelism is the path to realize that high performance.
The focus of this first article is to get up and running on Intel Xeon Phi as quickly as possible. Complete working examples will show that only a single offload pragma is required to adapt an OpenMP square-matrix multiplication example to run on a Phi coprocessor. Performance comparisons demonstrate that both the pragma-based offload model and using Intel Xeon Phi as an SMP processor compare favorably against the MKL library optimized for the host, and that the optimized Phi MKL library can easily deliver over a teraflop. A second installment, next week, will discuss how programming the Phi compares with CUDA programming.
The Xeon Phi Hardware Model from a Software Perspective
The Intel Xeon Phi KNC processor is essentially a 60-core SMP chip where each core has a dedicated 512-bit wide SSE (Streaming SIMD Extensions) vector unit. All the cores are connected via a 512-bit bidirectional ring interconnect (Figure 1). Currently, the Phi coprocessor is packaged as a separate PCIe device, external to the host processor. Each Phi contains 8 GB of RAM that provides all the memory and file-system storage that every user process, the Linux operating system, and ancillary daemon processes will use. The Phi can mount an external host file-system, which should be used for all file-based activity to conserve device memory for user applications. Even though Linux on Intel Xeon Phi provides a conventional SMP virtual memory environment, the coprocessor cards do not support paging to an external device.
Figure 1: Knights Corner microarchitecture.
A preproduction card using a Knights Corner chip achieved a score of 189 GB/s on the streams triad benchmark with ECC (Error Correcting Code) enabled. It is expected the production Intel cards shipping next month will deliver higher performance. The theoretical maximum bandwidth of the Intel Xeon Phi memory system is 352 GB/s (5.5GTransfers/s * 16 channels * 4B/Transfer), but internal bandwidth limitations inside the KNC chips (specifically the ring interconnect) plus the overhead of ECC memory limit achievable performance to 200 GB/s or less.
Each Intel Xeon Phi core is based on a modified Pentium processor design that supports hyperthreading and some new x86 instructions created for the wide vector unit. As illustrated in Figure 2, developers need to utilize both parallelism and vector processing to achieve high performance. Programmers are free to work with their preferred programming languages and parallelism models so long as the application can scale to match Phi capabilities.
Figure 2: High-performance Xeon Phi applications exploit both parallelism and vector processing.
Per the analysis presented earlier in my Dr. Dobb's Journal article, "Intel's 50+ Core MIC Architecture," memory capacity will likely be the main limitation for the current generation of Phi devices (previously called "MIC") especially for those who wish to run native SMP or MPI applications directly on the device.
The current PCIe packaging complicates the offload programming model as external data breaks an assumption made by the SMP execution model that any thread can access any data in a shared memory system without paying a significant performance penalty. As can be seen in Figure 3, the PCIe bandwidth is significantly lower than that of the on-board memory.
Figure 3: PCIe and memory bandwidths.
So achieving high offload computational performance with external coprocessors requires that developers:
- Transfer the data across the PCIe bus to the coprocessor and keep it there
- Give the coprocessor enough work to do
- Focus on data reuse within the coprocessor(s) to avoid memory bandwidth bottlenecks and moving data back and forth to the host processor.
Be aware that the preproduction Intel Xeon Phi cards have only one DMA engine, so any communications (network file-system, MPI, sockets, ssh, and so forth) between the coprocessor and host can interfere with offload data transfers and thereby w application performance.
While the aggregate Intel Xeon Phi computational performance is high, each core is slow and has limited floating-point performance when compared with a modern Sandy Bridge processor. High performance can be achieved only when a large number of parallel threads (minimum 120) are utilized, and they issue instructions to the wide vector units quickly enough to keep the vector pipeline full. The current generation of coprocessor cores support up to four concurrent threads of execution via hyperthreading. Most developers will rely on the compiler to recognize when the Intel Xeon Phi special wide vector instructions can be issued to the per core vector units. (More-adventurous programmers can utilize compiler intrinsic operations or assembly language to access the vector units.) This means that existing libraries and applications must be recompiled to run well on the Phi. In general, the best floating-point performance will be realized when each core is running two threads that actively issue instructions to the vector unit. For a 61-core coprocessor, this means that the programmer must be able to effectively utilize 120 threads (two times of the number of cores minus one core reserved for the operating system) inside their application.
Empirically, it appears that the internal Pentium cores are not fast enough to keep their associated per core vector unit busy when running only one thread. Running with two threads per core appears to be the generic minimum thread count, best performance sweet spot. This is only a general rule of thumb, as much depends on the type and amount of work performed by each thread before it issues a vector operation. (Note that future Intel Xeon Phi products will likely support greater parallelism, so the ability to support higher application thread counts is highly encouraged.)
The key to Intel Xeon Phi floating-point performance is the efficient use of the per core vector unit. To access the vector unit, the compiler must be able to recognize SSE-compatible constructs so it can generate the special Intel Xeon Phi vector instructions. Developers with legacy code can test if their applications will benefit from Xeon Phi floating-point capability by simply telling the compiler to utilize the SSE instructions on the current x86 processor (through the GNU
–msse or other compiler switch). Applications that run faster with SSE (or conversely slow down when the use of SSE instructions is disabled) will likely benefit from the Intel Xeon Phi wide vector unit. Applications that don't benefit from the SSE instruction set will be limited to the performance of the individual Pentium-based cores. Although this means Intel Xeon Phi will probably not be a performance star for non-vector applications, these coprocessors can still be used as support devices that provide many-core parallelism and high memory bandwidth.

subset: commoncrawl


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Invensis Learning's CAPM® Exam Prep Training Course in Konya is delivered by highly qualified trainers with extensive Project Management experience. This PMI's Certified Associate in Project Management is an entry-level project management certification for project managers and project practitioners worldwide. This CAPM Certification Course in Konya is ideal for individuals and enterprises who are looking to gain a fundamental understanding of project management.
The main takeaways from this CAPM Certification course in Konya are that one will gain a formal understanding of A Guide to the Project Management Body of Knowledge, (PMBOK Guide 6th Edition). Participants will also receive a hard copy of the PMBOK Guide 6th Edition and 23 PMI PDUs.
We deliver CAPM Exam Prep Training in Konya through classroom and live online virtual modes. Attend this CAPM course from various available weekday and weekend schedules. Enroll now and gain this CAPM certification in Konya today.
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- PMBOK® Guide processes and knowledge areas
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To be eligible for the CAPM certification exam, you must meet certain educational and professional requirements:
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The CAPM Exam fees for PMI Members are $225 and for non-members is $300.
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Many of our participants in Konya become a CAPM certified professional in just 4 to 6 weeks. Our unique training methodology coupled with high-quality CAPM courseware enables our participants to achieve their CAPM certification goal. With a careful assessment of each participant, we assign a trainer who creates a structured approach to the training that helps in achieving desired CAPM results.
At Invensis Learning, we create a 'Study Smart' approach for participants taking up CAPM training in Konya. As a training organization, our main objective is to achieve over 95% passing success for participants who take up CAPM exam prep training with us. The trainer will devise a smart study approach by understanding each participant carefully and devise measures during the training to understand the areas that you are struggling with and create a teaching plan accordingly. At the end of the training, the trainer will share a detailed report and help in creating a customized plan that helps in clearing your CAPM certification exam in Konya.
At Invensis Learning, we believe in holistic learning that encompasses a clear understanding of the concepts rather than memorizing and using flash cards to clear the exam. These short-cuts only help you to a certain extent, but a proper understanding of the concepts helps participants to answer questions of various difficulty levels and ensures it stays with them which help in the real-world application as well. Moreover, the entire training is focused on showcasing minute details of project scenarios and mapping it to PMI's project management way of thinking.
This introductory module discusses what PMI is and about CAPM in general where it talks about the route to CAPM certification, CAPM exam syllabus, CAPM exam format, exam tips and strategies, an overview of ITTOs, and CAPM Exam Fee Structure
This module focuses on what is a project, project management, project constraints, program management, portfolio and organizational project management, the role of PMO, managing stakeholders and more.
This module discusses PMI processes, project lifecycle, 5 project management process groups, tailoring, and mapping the knowledge areas, process groups, and processes
This module focuses on project integration management. This knowledge area of integration management distinguishes that the profession of project management does not work in isolation, and there is a higher dependency between different knowledge areas of project management
This module helps in understanding processes in planning, defining, managing, and controlling changes as per the project requirements, scope and work breakdown structure. Overall, there are six processes in scope management.
This module helps a participant to gain a comprehensive understanding of project time management. This module is all about planning that helps in creating a robust schedule management plan for a project. This whole planning is iterative that helps in regularly updating the project schedule.
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This module focuses on the critical aspect of project quality management. Project Quality Management sheds light on having a quality management plan, performing quality assurance that defines and keeps a check on the quality of the all the processes in the project.
This module focuses on understanding Project Resource Management. Once again, this module starts with creating a resource management plan. There are three other processes that involve carrying out the resource management plan in acquiring, developing, and managing the project team.
This module focuses on understanding Project Resource Management. Once again, this module starts with creating a resource management plan. There are three other processes that involve carrying out the resource management plan in acquiring, developing, and managing the project team.
This module focuses on one of the significant topics in the PMBOK Guide that is Project Risk Management. This knowledge area begins with creating a project risk management plan, identify risks, and perform qualitative and quantitative risk analysis, plan, implement and control risk responses throughout the project.
This module focuses on project procurement management. It starts with planning procurement, conducting procurement, and controlling procurement. Closing procurement process has been removed from the new PMP 6th edition.
This module is the final frontier to your overall understanding of project management as per the PMBOK Guide 6th Edition. This module does not start with planning stakeholder engagement but with identifying who the stakeholders are and then managing and monitoring stakeholder engage throughout the project.
The daily agenda of the 4-day CAPM Training is detailed below:
As part of your CAPM training, you will receive:
CAPM can be applied to all sorts of projects in construction, oil and gas, energy, banking, financial services, ICT, engineering and in various other industries as well.
Yes, PMP usage is universal and can be used for any project of any size.
No, the course fee does not include the exam fee, and it is only for earning the required number of contact hours (23 contact hours) to appear for the CAPM certification exam.
US $225 is the CAPM exam cost for PMI membership holders and US $300 for non-members
The CAPM examination blueprint identifies the proportion of questions from each chapter of the PMBOK® Guide that will appear on the examination. The questions are derived by combining the overall evaluations of importance, criticality, and frequency, and by converting the results into percentages.
The percentages are used to determine the number of questions related to each chapter that appear on the examination.
|PMBOK® Guide - Fifth Edition Chapter
|Percentage of Questions
You have 90 days to complete and submit the CAPM application once you start filling it. If the application is selected by PMI for an audit, then you have to submit the audit materials within 90 days.
You can take the CAPM exam up to 3 times, within the 1-year validity period from the date of your application approval. But, you have to pay the re-examination fee.
The CAPM certificate is valid for 5 years.
Individuals and Enterprises can make payment for the training through 3 different modes such as –
For more information on payment details, please contact us at email@example.com
In order to renew your CAPM credential, you have to schedule, sit for and pass the re-certification examination. You must apply for re-certification and take the examination during the fifth year of your certification cycle.
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text: Friday, January 04, 2013 One Year After Stroke, Sen Kirk Climbs Capitol Steps On Thursday, Sen Mark Kirk (R-IL) returned to Capitol Hill for the first time since having a stroke in January 2012 that paralyzed the left side of his body. Kirk climbed the steps to the Capitol using a 4-prong cane and assisted by Vice President Joe Biden and Sen Joe Manchin (D-WV) while his colleagues in the 113th Congress cheered. Kirk was scheduled to hold a press conference Thursday with physicians and researchers from the Rehabilitation Institute of Chicago and Northwestern Memorial Hospital to discuss the treatment he underwent. APTA member Michael Klonowski, PT, DPT, PCS, who was Kirk's primary physical therapist in Chicago, told USA Today that he was "more emotional" than he thought he would be as he watched his former patient make the climb. "Seeing what he's done is absolutely inspiring," Klonowski said. "I've seen him go up tons of stairs. ... It was really something to see him do what he did today." In an interview published Wednesday in the Chicago Sun-Times Kirk said that his experience with the health care system has given him a new perspective. He said that he plans to take a look at the Illinois Medicaid program, which he noted allows 11 rehab visits for patients with stroke. "Had I been limited to that, I would have had no chance to recover like I did," Kirk said. "So unlike before suffering the stroke, I'm much more focused on Medicaid and what my fellow citizens face." Watch this NBC video of Kirk's "45 monumental steps." To view photos of Kirk in rehabilitation, visit the Huffington Post. Comments I don't know if you saw this but this is an interesting follow up to that. http://articles.chicagotribune.com/2013-01-04/news/ct-met-mark-kirk-health-care-0104-20130104_1_speech-therapy-occupational-therapy-health-insurance Posted by Laura OConnor on 1/8/2013 12:49 PM Maybe Senator Kirk can help persuade the rest of his colleagues that physical therapy has real value, that undermining our payment is in nobody's best interest and that significant reductions in visit allowances are harmful. By the way, if his insurance used a 3rd party administrator to oversee the utilization of his care, he might have only made it 15 steps and been left to work on the remaining 30 independently!! Posted by Gregory Given -> =HTcEM on 1/9/2013 10:59 PM


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With its CA World event just a few days away, CA Technologies has detailed software engineering advancements that resulted in a new SaaS-based Application Performance Management (APM) solution.
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This APM-as-a-Service (APMaaS) offering will be capable of shouldering the transactional processing challenge of coping with billions of events across data centers as well as across public, private, and hybrid clouds.
This is essentially a multi-tenant highly scalable set of services and is described as full featured enough to be capable of proactively monitoring the transactions of all users in a defined network or space. CA says that this is deep application diagnostics in a 24x7 delivery environment.
CA further asserts that its APMaaS technologies are capable of proactively identifying, diagnosing, and resolving performance problems before they affect end users and disrupt revenue-generating services.
The firm points out that its APMaaS solution will proatively monitor components of web applications, websites, and cloud services including components delivered by third parties. It will also achieve visibility not just to understand but optimize the end user experience.
The CA product management team noted that this software will employ on-demand dashboards, public status pages, and reports. "[CA APMaaS] tracks and optimizes critical API integration points and reliability, whether your organization provides APIs to third parties, or relies on other organizations' APIs to view existing CA APM solution results augmented with essential synthetic performance metrics for integrated performance views from inside and outside the firewall."


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Greg Wyshynski
Hearing 2 other NHL teams have staff called back or on stand by. That's 4 total. Again, could be precaution. Sh*t'll move fast after that.
Ok, more players showing up for player run practices. Players returning from Europe (ok, a lot of teams in Europe are on break). Teams calling staff back.
Is the end near? And I don't mean Mayan end... although that's 11 days away...


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States struggling with unfunded pension liabilities could come up with tens of billions fairly quickly by simply cutting Wall Street out of their fat pension management contracts.
That is the oft-stated conclusion of a new study by the Maryland Public Policy Institute which, though filled with unflattering statistical comparisons between actively managed portfolios and passively managed index funds, reads at times like a personal feud with Wall Street professionals.
The paper's authors, affiliated with the free-enterprise-oriented state policy nonprofit and also the Maryland Tax Education Foundation, bemoan their state's "opportunity cost" of $2 billion to $3 billion as a result of Maryland pension system's 10-year underperformance despite their previous written reports and public testimony.
"The response of the system to these facts has been to 'shoot the messenger' rather than to acknowledge the problem, admit a mistake and institute reforms," write report authors Jeff Hooke and John J. Walters. "The response of the governor and Legislature has been to do nothing. This 'head in the sand' tactic is mirrored by Maryland's underperforming peers despite the huge dollars involved."
The authors analyze 46 of the 50 states, excluding four states whose data lacked comparability. They found that, net of fees, the top 10 states paying the highest pension management fees to Wall Street (averaging 0.6%%) had five-year returns (ending June 30, 2012) of 0.34%, compared with a 2.38% return for the 10 states paying the lowest fees (averaging 0.22%) over the same time period.
"State pension funds should consider indexing," the report advises. "Indexing fees cost a state pension fund about 3 basis points yearly on invested capital vs. 39 basis points for active management fees (or 92% less)."
That difference could save the surveyed 46 funds $6 billion in fees annually while delivering similar or superior returns. Comparing 5-year median pension performance to a benchmark that mimics the asset allocation of state pension funds, the authors find a 0.69% annualized return advantage to the index fund.
"Although 0.69% doesn't sound like much, on a $30 billion portfolio, it represents $207 million per year, or over $2 billion for ten years, when compounding is used," the authors write.
They add that were states to expand the small proportion of their pensions that are passively managed to 80% or 90% of their portfolios, "the annual savings, at a seven percent liability discount rate, reduces unfunded pension liability by $80 billion," thereby improving results for both taxpayers and public sector employees.
The paper's authors argue that state pension systems routinely fall for a Wall Street "sales pitch" that says fund professionals can outperform the market with their investment savvy. Yet they cite S&P Dow Jones data to show that over the five years ended December 31, 69% of domestic equity funds failed to beat the S&P benchmark while fully 13 out of 14 bond benchmarks beat actively managed fixed-income funds.
They decry what they view as a lack of accountability on the part of state pension system managers, who fall for the "sales pitch," add to costs by monitoring performance with the help of outside "Wall Street-type" investment consultants, yet take no action in response to underperformance.
Maryland, for example, has seen little money manager turnover. "In fiscal 2009," the authors write," "the market crash caused the system to lose billions. None of the high-priced money managers saw the crash coming, yet they kept their system contracts. This non-accountability is not specific to Maryland, but endemic to the public pension fund sector."
Hooke and Walters' solution — noting the classic investment exposé "Where are the Customers' Yachts?" — is to fire Wall Street, which they argue should not be politically difficult to accomplish:
"Fee cuts will impact principally the incomes of public stock and bond money managers, hedge fund managers, and private equity fund managers, who are concentrated in just a few states."
The authors are vocal in their encouragement of a transition to indexing, going through details of the process:
"Indexing is easy for states to implement, as index firms respond to state requests for proposals (RFPs) just like active managers. A state can liquidate most of its active manager portfolios within a few months, and provide the cash to index firms, which can then invest the money in the underlying securities of an index within a few weeks."
The authors also reserve some choice words for Wall Street trends such as alternative investments, which they call "old wine in a new bottle," and private equity funds, whose portfolio valuations by independent CPAs they describe as "less than rigorous."
Check out Will Indexing Kill the Market? on AdvisorOne.


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FitBall USA Core Strength Products
When it comes to rehabilitation products, FitBall USA sets the standard. FitBall USA exercise balls, FitBall USA therapy balls, and FitBall USA stability balls offer the ultimate products for resistance work. Easy to grip and fun to use, FitBall USA products get the job done. We have balls in various sizes, along with air cushions, seating discs and flexibility pads. Why settle for second best when you can use FitBall USA products? Read More Read Less
5 Items
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Undergraduate Degrees, Majors and Concentrations
FINA4100 - Real Estate Investmnt Analysis
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This course examines the unique valuation and financing problems associated with income-producing real property. Real estate is not fungible, i.e., each unit is unique and has no perfect substitute. Real property is further distinguished from other investment vehicles by the fact that its value is a function of how an investor plans to use it. Students receive an insight into the complexities of real estate investment and financing including property selection, taxes, various ownership forms, and insurance. The course emphasizes the financial aspects of real estate including appraisal, feasibility analysis, and the markets for income producing properties. It provides an opportunity to apply valuation principles learned in other finance courses.
Prerequisites: FINA3100 and 90 credits
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Prerequisites: FINA3100 and 90 credits
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Vintage Clock Blue Butterfly Paris Eiffel Tower FashionMade from a fine microfiber material, this glasses cloth will clear any dirt and smudges from your spectacles in no time. The soft fabric will allow you to remove fingerprints and dust off your lenses without damaging the surface, making this a useful accessory to take with you. Measures approximately 7"(w) x 6"(h).
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The administration and congressional Democrats agree on the need to update the FISA statute to reflect the realities of 21st-century telecommunications, including the ever-expanding digital world of e-mail, podcasts and text messages.The vote was 60-28, so it's clear that Democrats, much as they'd like to put their mark on the legislation, cannot bear to look as though they accept a greater risk of terrorist attacks.
White House and intelligence officials have sought a broad overhaul of the act to allow spy agencies to listen in on terrorism suspects quickly, without having to apply for a court order, as is required for surveillance that targets U.S. residents. But Democratic leaders say the administration's proposals could lead to broad searches of phone calls and e-mails by ordinary Americans without judicial review....
White House officials complained that Democratic proposals do not give them a crucial tool: the ability to begin wiretapping without having to go to a court. "Every day we don't have [this wiretap authority], we don't know what's going on outside the country," a senior White House official said. "All you need is one communication from, say, Pakistan to Afghanistan that's routed through Seattle that tells you 'I'm about to do a truck bomb in New York City' or 'about to do a truck bomb in Iraq,' and it's too late."
Marty Lederman gives some detail on the failed Democratic proposal, which "the communications privacy community" considered "too conciliatory... going well beyond authorization to exclude purely foreign-to-foreign communications from FISA, i.e., far beyond what is necessary to address the problem that the Administration has described."
Joe Gandelman writes:
... Bush held out for the strongest deal he could get, went on TV and seemingly scared some Democrats to go along with him (some other Democrats clearly agreed the law update was needed) since his TV talk centered on how critical it was to give government these new updated tools to protect the U.S. And it worked — indicating a) he still has a lot of clout since he can peel off wavering or sympathetic Democrats so they join in coalition with GOPers and b) if it worked this time chances are this tactic will be used on other high-stakes measures....The Talking Dog barks:
Harry Reid voted against it in every way except the one way that mattered: he had the power to keep this piece of shit off of the Senate floor altogether, and to tell the President that when the President started respecting the Constitution and the rights of the American people, then he could start suggesting legislation of this kind... and not dictating to another branch of government what it should pass or when it should recess. And instead, on this, we get "an up or down vote". Jebus.The Dog is reading Digby, who writes:
... [W]e can presume that the D.C. cocktail party circuit is all abuzz about fear of terrrrrrrrrorists attacking Washington any God damned moment... and, unbelievably, Democrats believe that they would be blamed for it. And again, methinks, why was it I worked so hard to get this party in the majority again, so we could get exactly the same results as if they weren't?
I have the niggling feeling that there has been some pretty heavy cocktail and bar-b-que chatter in the capital this summer with the elders warning everyone that something is afoot, but they can't talk about the details. Suddenly the villagers are all acting like nervous cats on a hot tin roof and dancing around like it's the hot summer of 2002 again for no discernable rason [sic].Americablog:
If that's so and little birdies are whispering in ears, the congress should stay in town and hash this thing out for real instead of signing off on something they haven't read. And if that's so, the president also needs to stay in town instead of rushing off to clear that poor brush again on his "ranchette" set in Waco and negotiate in good faith to protect the American people. The fact that nobody is doing this suggests to me that if there is some fear mongering going on, everyone involved knows it's typical Bushian nonsense but they are afraid to take a chance just in case he gets lucky and hits another trifecta.
No. More. Executive. Power. Period. It's their job to figure out how to track terrorists without trampling on the constitution. If that means staying in town for the month August in that sweltering heat, well, that's what they're paid for.
So much for that "one of the people being listened to needs to be a terrorist" line that Bush kept selling us. Apparently, he never intended that to be the case, and now it isn't. And the more congress permits itself to be rolled, the more Bush knows he can roll them. The man is at 28% in the polls and the Democrats are scared to death of him. Pathetic.
Yes, and how has Congress been doing in the polls?


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Clinical Trials
A Safety and Efficacy Trial of Dapivirine Vaginal Ring in Africa
International Partnership for Microbicides, Inc.
Information provided by (Responsible Party)
International Partnership for Microbicides, Inc.
First received: April 13, 2011
Last updated: June 8, 2012
Last Verified: June 2012
History of Changes
This is a double-blind, randomized, placebo-controlled Phase III study to asses the safety and efficacy of a silicone elastomer vaginal ring containing 25mg of dapivirine.
HIV Infections
Other : Dapivirine
Other : Placebo
Drug : Dapivirine
Phase 3
|Study Type:
|Study Design:
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Prevention
|Official Title:
|A Multi-Centre, Randomised, Double-Blind, Placebo-Controlled Phase III Safety and Efficacy Trial of a Vaginal Matrix Ring With Dapivirine for the Prevention of HIV-1 Infection in Women
Further study details as provided by International Partnership for Microbicides, Inc.:
Primary Outcome Measures
Efficacy as determined by HIV-1 seroconversion rate per person-years of product use, measured at the end of the investigational product use period.
[ Time Frame: 15 months ]
The primary endpoint is HIV-1 seroconversion measured by rapid and specialized laboratory tests according to a comprehensive HIV testing algorithm. This algorithm employs a series of high specificity and high sensitivity immunoassay-based HIV blood tests that minimize the chance of false positive results to determine if a subject is positive for HIV. Endpoint confirmation of HIV infection is by Western blot.
Safety as determined by grade 3 and 4 AE's, clinically significant grade 2 laboratory findings (based on DAIDS grading) and all serious AE's.
[ Time Frame: 15 months ]
This will be measured by self-reports, physical examination, safety laboratory tests and other specialised investigations.
- Adherence to the protocol-specific product regimen as determined by self-reported diary cards and questionnaires. [ Time Frame: 15 months ]
- The incidence of curable STI's or pregnancy as determined by STI testing and pregnancy testing. [ Time Frame: 15 months ]
|Study Start Date:
|July 2011
|Estimated Study Completion Date:
|July 2014
|Estimated Primary Completion Date:
|July 2014 (Final data collection date for primary outcome measure)
|Assigned Interventions
Vaginal ring containing 25mg of dapivirine
Vaginal ring containing 25mg dapivirine; one ring inserted every 28 days for at least 15 months
Drug: Dapivirine
Placebo Comparator:
Placebo Ring
Vaginal ring containing no drug substance
Vaginal Ring containing no drug substance
|Ages Eligible for Study:
|18 Years to 40 Years
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Women >18 and <40 years of age who can provide informed consent
- Available for all visits and consent to follow all procedures scheduled for the trial
- Generally healthy and self-reported sexually active (defined as an average of at least one penetrative penile vaginal coital act per month for the last 3 months prior to enrolment)
- HIV-negative as determined by the HIV algorithm applied at screening and enrolment
- On a stable form of contraception and willing to continue on stable contraception for the duration of the clinical trial;
- Asymptomatic for genital infections at the time of enrolment (if a woman is diagnosed with any clinically significant treatable STI, she must have initiated treatment at least 1 week prior to enrolment and have completed the full course of treatment)
- Willing to answer questions about adherence, sexual behaviour, vaginal practices and ring acceptability;
- Willing to provide adequate locator information for trial retention purposes and be reachable per local standard procedures (e.g., by home visit or telephone; or via family or close neighbour contacts [confidentiality to be maintained])
- Willing to refrain from participation in another research trial using drugs, vaccines, medical devices, microbicides or oral pre-exposure prophylaxis investigational drugs for the duration of the IPM 009B trial;
- In the absence of the use of exogenous hormone(s), have a self-reported regular menstrual cycle defined as having a minimum of 21 days and a maximum of 35 days between menses;
- Willing to refrain from use of vaginal products or objects including spermicides, tampons, female condoms, cotton wool, rags, diaphragms, cervical caps (or any other vaginal barrier method), douches and drying agents within 14 days from enrolment and for the duration of the trial.
Exclusion Criteria:
- Currently pregnant or last pregnancy within 3 months prior to screening;
- Currently breast-feeding
- Participated in another research trial using drugs, medical devices, microbicides or oral pre-exposure prophylaxis agents within 60 days prior to screening
- Previously participated or currently participating in any HIV vaccine trial
- Untreated, clinically significant urogenital infections (either symptomatic or asymptomatic), e.g., urinary tract or other sexually transmitted infections, or other gynaecological symptoms within 1 week prior to enrolment
- History of significant urogenital or uterine prolapse, undiagnosed vaginal bleeding, urethral obstruction, incontinence or urge incontinence
- Any gynaecological surgery within 90 days prior to enrolment
- Any Grade 3 or 4 baseline haematology, chemistry or urinalysis laboratory value according to the DAIDS Table for Grading Adverse Experiences, or clinically significant Grade 2 findings
- Any history of anaphylaxis or severe allergy resulting in angioedema; or a history of sensitivity/allergy to latex or a silicone elastomer
- Any history of diabetes mellitus and chronic use of oral steroid therapy and any uncontrolled serious chronic or progressive disease
- Cervical cytology at screening that requires cryotherapy, biopsy, treatment (other than for infection), or further evaluation [this includes any findings of atypical squamous cells of undetermined significance (ASCUS)]
- Any condition(s) that, in the opinion of the investigator, might put the participant
Contacts and LocationsChoosing to participate in a study is an important personal decision.Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01337583
Locations Show More
|Suba District Hospital
|Mbita, Kenya
|University of North Carolina Project
|Lilongwe, Malawi
|South Africa
|Desmond Tutu HIV Foundation, Nyanga (DTHF)
|Nyanga, Cape Town, South Africa
|Prevention of HIV / AIDS (PHIVA) Project
|Pinetown, KwaZulu Natal, South Africa, 3610
|Maternal, Adolescent and Child Health (MatCH)
|Plessislaer, South Africa, 3216
Sponsors and CollaboratorsInternational Partnership for Microbicides, Inc.
|Study Director:
|Annalene Nel
More Information
|Responsible Party:
|Annalene Nel, MBChB, PhD, International Partnership for Microbicides, Inc.
|ClinicalTrials.gov Identifier:
|NCT01337583 History of Changes
|Other Study ID Numbers:
|Study First Received:
|April 13, 2011
|Last Updated:
|June 8, 2012
Keywords provided by International Partnership for Microbicides, Inc.:HIV Infections
Anti-HIV agents
Additional relevant MeSH terms:
HIV Infections
ClinicalTrials.gov processed this data on May 24, 2020
This information is provided by ClinicalTrials.gov.


text:
256 0065
Lotus Touch Introductory Aromatherapy Package
New to aromatherapy? Looking to expand your offering or perhaps you're an experience professional looking for new oils and supplies.
This basic aromatherapy package provides you with the essentials to provide aromatherapy services to your clients.
Package includes premium, therapeutic grade Lotus Touch Essential Oils. A variety of single notes, such as lavender and peppermint and our most popular blended oils are included. Whether a single note or a blend, these pure aromatherapy oils are 100% pure. No fillers, preservatives or additives.
(*Click on the Kit Content links above to learn more about these products)
|Brand Name
|Lotus Touch®
Sort By:


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A new investment commentary from Rob Arnott's firm, Research Affilliates, proposes investment firms do their part to cultivate budding financial geniuses in their midst.
The unusual topic choice for its May newsletter may be par for the course for Research Affiliates. The firm is recognized for its outside-the-box approach to index construction.
Indeed, the firm has even been granted a patent for its methodology of weighting its indexes on the basis of investment fundamentals (as opposed to conventional weighting according to market capitalization).
So perhaps it is not suprising that the firm's vice president of brand management, Phillip Lawton, would delve into a topic that reinforces the niche research firm's market position and identity.
Lawton notes that financial geniuses are no more common than scientific geniuses like Einstein and Edison.
When a Harry Markowitz comes along and proposes modern portfolio theory and efficient markets hypothesis, or a William Sharpe develops his capital asset pricing model, their conceptual frameworks "have equipped several generations of investment professionals to…vastly increase the range of available strategies and instruments for taking on and laying off risk."
But Lawton worries that the pace of financial genius could be mirroring a slowdown in the natural sciences, where the vast amount of knowledge required to reach the conceptual frontier has become harder than ever to attain.
Cracks are appearing in the prevalent view that markets are efficient, with much evidence, coming particularly from behavioral finance, that "flesh-and-blood investors are at best imperfectly rational."
Progress in behavioral finance, "emotional finance" and neuroeconomics may eventually lead to new and improved valuation models.
But how can the industry help when some lack the time and energy to appraise new ideas and others eschew the career risk of nonconformist thinking?
"Can investment research teams accommodate inventors and iconoclasts? Can truly original thinkers function as members of a team?" Lawton asks.
The tendency of brainstorming sessions to lead to conformist thinking, the tendency of others to defer to higher-ups as well as inhibitions about sounding foolish in voicing novel ideas area all barriers to finding new patterns of mispricing.
Lawton proposes that investment managers counter these tendencies with a collegial atmosphere that incentivizes the critical evaluation of ideas, even seemingly outlandish ones.
The Research Affiliates exec—maybe because he works at Research Affililates—says he is optimistic that "a new, principles-based investment theory…is in the offing," and predicts "it will emerge from the collective efforts of many gifted, accomplished, arguementative, sleep-deprived thinkers."
Read 'Modern Portfolio Theory Is Dead': Sierra's David Wright on AdvisorOne.


text: About this CapOur adjustable, 100% brushed cotton Cap is unstructured and an ideal way to beat the heat. Wear it anytime you want to keep the sun off or cover up a bad hair day. It features a sturdy low profile brim, sweatband, and adjustable closure, as well as Premium Printing for images that last.Adjusts from 20 to 24 inches (approximately 51 to 61 cm). Available in Khaki or white.


text:
Raymond James Financial (RJF) said early Thursday that it tapped Kevin Monaco, a former Morgan Stanley manager and recruiter, to help it grow its employee advisor channel, Raymond James & Associates, in the San Diego area.
Monaco will join the eight existing employee advisor branch managers in California, along with the recently hired Seattle manager, David Wright.
"As Raymond James looks to deliver on our objective of establishing a number of new RJA offices in the western part of the country, we are delighted to have hired such a proven talent as Kevin to represent us in Southern California, and more specifically in the San Diego area our tenth California location," said Tash Elwyn, president of Raymond James & Associates, Private Client Group, in a press release. "His experience in building and developing teams of advisors is just what we are looking for as we build out this market."
Monaco started his work in the business in 1993 as an advisor trainee with Merrill Lynch (BAC) in Cleveland. He moved to Morgan Stanley (MS) in 1997 and worked as an advisor until 2003, when he relocated to Chicago as a nonproducing sales manager with Smith Barney.
In 2006, Monaco was tapped as a nonproducing branch manager in Glendale, Calif., supervising 40 professionals and later the local Morgan Stanley/Smith Barney integration. Monaco later served as an executive director and business-development manager for Morgan Stanley Wealth Management in Los Angeles.
"I joined Raymond James to get back to what I enjoy most building an office from scratch and being a high-energy advocate for advisors who are motivated to succeed and dedicated to their craft," said Monaco, in a statement. "I understand the challenges facing today's financial professionals, and I'm passionate about helping top-producing advisors in the San Diego area serve their clients' best interests, advance their careers and establish succession plans that give them total control of their businesses.
Financial Results
Late Wednesday, Raymond James said its advisors had total securities commissions and fees of $245 million in August, up 1.3% from July but down 2% from August 2012.
Client assets under administration were $410 billion, a drop of 2% from July and a jump of 8% over last August. Meanwhile, financial assets under management of $54 billion were down 1.8% from July but up 29% from a year ago.
The S&P 500 index was down 3.13% in August 2013 vs. July 2013 and up 16.1% from last year.
"August posted solid results given a decline of over 3% in the S&P 500 and continued volatility in longer term interest rates," said CEO Paul Reilly in a statement.
"We have essentially completed the Morgan Keegan integration and remain focused on serving our clients and advisors, our growth initiatives and cost structure," Reilly added.
As of June, 30, Raymond James had 5,428 advisors in the United States and 6,301 reps worldwide, including those in its independent, employee, bank and other channels.
Check out the latest blogs on ThinkAdvisor.


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text:
The quarterback job at Florida comes with high expectations and plenty of scrutiny.
A few days after a shaky performance in a lackluster win over Maryland and Boomer Esiason in 1981, Wayne Peace decided he needed to get away from all the pressure and attention that come with being the starting quarterback at Florida.
Peace and his girlfriend made their escape to a youth football team's practice in northwest Gainesville, way out near Santa Fe Community College, where Peace figured watching a bunch of young kids playing the game for fun would be good therapy and give him perspective.
The peace did not last long.
"The folks behind us apparently didn't recognize me," Peace said. "The guy brought up the Maryland game to his wife and he started talking about, 'What a crappy game Peace played on Saturday.' He went on and on.
"I never said a word to him. There was nothing I could say or do. I just sat there."
Such is life for the starting quarterback at Florida.
Being the Florida quarterback is a coveted title, one that can bring glory and fame (and maybe even a fat NFL contract). It also comes with lots of pressure, scrutiny and almost certain criticism.
It is a life lived, and a game played, under a microscope.
There is no escape.
"It's something that comes with the job description," Shane Matthews said. "Whether you're at Florida or Alabama or Ball State, you're going to be the big man on campus. You've got to act the right way on and off the field. The attention is always focused on the quarterback.
"I'm a firm believer that the quarterback gets too much credit when a team wins and too much blame when it loses. It comes with the quarterback position. It's tough. It's a little tougher nowadays with cell phones and the social media."
Matthews is one of UF's great quarterback success stories. He rose from the bottom of the depth chart to become Steve Spurrier's first starting quarterback at Florida. He led the Gators to their first SEC title, was the league's most valuable offensive player and a three-time All-SEC pick.
But he was not above the criticism that can come with the position.
"There were times (when I heard the criticism)," Matthews said. "You've got to have thick skin to be a quarterback. I don't think any quarterback has ever played a perfect game. You're going to get criticized."
No Florida quarterback has been immune from it. Not Matthews. Not Peace. Not Spurrier. Not Kerwin Bell. Not Danny Wuerffel. Not Doug Johnson. Not even Tim Tebow (although some might debate that).
Bell, the former walk-on from Mayo who emerged as a Heisman Trophy candidate in the mid-1980s, knows all about the pressure that comes with the job. And he knows how fickle the fans can be.
"In my first year (1984), the pressure didn't really hit me. I was just trying to hold on by the seat of my pants," said Bell, now the head coach at Jacksonville University. "Each year is different. As you head into your second year (as the starter) there are a lot more expectations.
"My first two years were great. We were 9-1-1 (in '84 and '85) and could do no wrong. When we were walking to or from practice, we didn't have to stop to cross the street (at what was then North South Drive). Fans would honk their horn letting you know it was OK to cross. Everyone loved the Gators.
"In my second two years (when UF went 6-5 and 6-6 under severe NCAA sanctions), when someone honked their horn at you it was to tell you to get out of the way. They were trying to hit a Gator. There is a lot of pressure when you start losing."
Win or lose, the pressure is always present if you're the Florida quarterback.
"That's a fact you accept when you come to a place like Florida," said Johnson, the former Buchholz High School star. "That's the reality. If you have confidence in yourself and in your ability, you welcome that."
The guy in the breach now is Jeff Driskel, the true junior who is coming off his first season as the Gators' starting quarterback.
He already knows about the heat and the pressure that come with the territory.
Despite helping lead the Gators to a big rebound season (11-2) in coach Will Muschamp's second second year, Driskel has taken all sorts of hits in the social media. Many have criticized his inconsistent play and questioned if he has what it takes to make the Gators championship material again.
To those critics, four former Florida quarterbacks (Peace, Bell, Matthews and Johnson) have a message: hold on, it's way too early to judge Driskel, a quarterback with a big arm and maybe even a bigger upside. Be patient, they say.
"I'm a huge Jeff Driskel fan," Peace said. "His tools as a quarterback are phenomenal. I think we're going to see some amazing things out of him as he continues to develop. Just look at his skill set. He has great size, runs a 4.5 40 and has one of the prettiest throwing motions you'll ever see. The guy can be phenomenal."
Peace said Driskel has already passed one major test. He's shown he can handle the pressure and criticism.
"He's kept his composure and he's always comes off as very intelligent in interviews," Peace said. "He doesn't lose his cool. I'm really impressed with how he's handled all that.
"The way he's handled criticism has been remarkable for a young quarterback. I can't say enough about Jeff Driskel and the situation he's in."
Matthews said he also likes Driskel's mental makeup.
"Most successful quarterbacks are mentally tough," Matthews said. "They don't care what the people on the outside are saying as long as they know they are the leader of the football team.
"Jeff is mentally tough. He's physically tough as well. He's got all the ability in the world, no question about that. He has a chance to be a heck of a quarterback. He's still learning the passing game. It's learning process and he'll get better over time."
Johnson said Driskel did what he was asked to do last year by Muschamp and offensive coordinator Brent Pease. He managed games well and put the Gators in a position to win games in the fourth quarter.
Now that he has a year of experience, Driskel's role likely will expand in the offense, Johnson said.
"I think he has the best head coach he could possibly have and an offensive coordinator that has a tremendous mind for calling plays," Johnson said. "I think he should be excited about where he's at.
"He's got tremendous athletic ability and obviously a strong arm. He's got a coach and a coordinator who will get the most out of him, and that will be fun to watch this season."
Bell said the dynamics will change for Driskel in his second year as the starter.
"Last year, they had a lot of young guys and a new offensive coordinator," Bell said. "They were doing what they had to do to win games: run and not go down the field that much (in the passing game). They always tried to put him in the best position. They protected him very well.
"In year two, more will be expected of him.The dynamic of the team will change. I think you're going to see him continue to improve. He's got the physical ability. You want to see if he can make reads a little quicker and anticipate a little better."
Bell said Driskel has a chance to evolve into a big-time quarterback.
"He's got a big arm and can move," Bell said. "He can avoid the rush, which is something you have to have at quarterback now. He has the ability to be a guy you can win championships with.
"The other things have to come, just be more instinctive playing the position. Those things have to be a little more natural. As you play and evolve, those things will come for him. I hope that's what Gator fans will see this season.
"Jeff has the ability to be a championship quarterback."
Contact Robbie Andreu at 352-374-5022 or email@example.com. Also check out Andreu's blog at Gatorsports.com.


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Talc is a naturally occurring substance that is used in cosmetic and baby powders as a filler material because of its consistency. It is an inert mineral with no inherent toxicity. Pure talc does not cause any skin reactions or irritations.
Concern over talc safety originated due to its association with asbestos which can occur in some talc deposits. Low grade talc used in the past by some companies were contaminated by asbestos, which is a known carcinogen.
Since 1972, government mandated testing and certification has ensured that ALL COSMETIC GRADE TALC is asbestos free. The FDA has approved cosmetic grade talc as safe. All talc used in products should be pharmaceutical grade, which is used in prescription tablets as filler, and is considered the purest form of talc.
Talc used in cosmetic products should be asbestos free.. Companies should choose to use talc instead of its substitute, corn starch, which has a high likelihood of being cross-contaminated with GMO corn.


text:
Enjoying Hot air balloon rides is something the entire family can participate in, but it is also a very popular way to celebrate an anniversary! When you speak with the pilot you are thinking about booking with, be sure to ask how many passengers will be in the basket.
When it is time for your ride, your pilot will offer to let you help with the assembly and inflation of the balloon. Go ahead and do it - it adds to the entire experience!
Can we fly at a balloon festival?
Check with your local balloon company to see if you can get your balloon ride during a nearby festival. Flying at a festival is a unique experience, and is one that you don't want to miss if possible.
Each festival has their own rules, and many do not allow paid passenger rides for several reasons, including FAA restrictions or insurance concerns. Some festivals, however, not only allow passenger flights but encourage spectators to fly by selling balloon rides at the festival.
Preplanning is the key - you'll want to know well in advance if you can fly at the balloon festival you plan to attend.
Famous Balloon Quote:


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New products introduced over the last week include a new high-yield bond ETF from Proshares and a partnership between Smarsh and NASDAQ OMX to offer offer Smarsh archiving and compliance solutions on the SMARTS platform.
In addition, S&P Capital IQ announced that it is expanding its ETF research offerings.
Here are the latest developments of interest to advisors:
1) ProShares Launches New High-Yield Bond ETF
ProShares announced Thursday the launch of ProShares High Yield-Interest Rate Hedged (HYHG), a new high-yield bond ETF that uses Treasury futures to provide a built-in hedge against rising interest rates.
HYHG maintains short positions in 2-, 5- and 10-year U.S. Treasury futures contracts to hedge its portfolio against possible rate increases.
It seeks to track the performance of the Citi High Yield (Treasury Rate-Hedged) Index, which aims to provide diversified exposure to a liquid portfolio of high-yield bonds while seeking to mitigate the impact of interest rate movements.
To be included in the index, bonds must have a minimum issue size of $1 billion, be issued within the past five years and have at least one year remaining until maturity. No more than two issues from one issuer are allowed, and no more than 2% of the index is allocated to a single issuer.
(The index does not attempt to mitigate other factors influencing the price of high-yield bonds, such as credit risk, which may have a greater impact on high-yield bond prices than changes in interest rates.)
2) NASDAQ OMX and Smarsh Establish Partnership
Smarsh announced at FINRA's 2013 annual conference a new partnership with NASDAQ OMX to offer Smarsh archiving and compliance solutions to corporations, broker-dealers, exchanges and regulators alongside NASDAQ OMX's SMARTS market surveillance and compliance solutions.
By combining the Smarsh archiving and compliance solutions with the SMARTS platform, customers globally will be able to fine-tune compliance and risk-management activities, the company says. The combined solution aims to provide users with the ability to extrapolate additional value through the correlation of trading data with employee and customer communication, such as e-mail, instant messages, mobile messages and social-media posts.
The Smarsh archiving and compliance platform features "granular search" (or data mining), review, supervision and reporting capabilities, leveraging a proprietary policy engine that strengthens risk-management processes and minimizes review workload by helping firms automate message supervision and other routine tasks traditionally done by compliance personnel.
3) S&P Capital IQ Expands ETF Research Offerings
S&P Capital IQ says it's added research coverage on hundreds of additional ETFs to its MarketScope Advisor platform. Reports and rankings are being made available on approximately 180 fixed-income ETFs, with reports offering asset class analysis also offered on more than 60 ETFs focused on commodities and currencies.
About half of the fixed-income ETF reports being added to S&P Capital IQ's research offering have a live history of less than three years, with roughly 50% of those having more than $100 million in AUM.
S&P Capital IQ will be using a holdings-based approach for the fixed-income ETFs, similar to that created by the company for equity ETFs, which will result in rankings of overweight, marketweight, or underweight. Factors that are considered in this approach include credit quality, interest-rate sensitivity, expense ratio and trading characteristics.
The research reports will also include credit default swap data and commentary and insights from S&P Capital IQ's experienced fixed income and ETF analytical teams.
Read the May 17 Portfolio Products Roundup at AdvisorOne.


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Hello Sexy! A stylish and sexy bandeau style top with laser cut details is one of the most popular tops from L Space collection.
With proper care, you will be able to enjoy your new swimsuit for many years to come.
For better results, follow these tips:
Although all our swimsuits are water safe, prolonged exposure to chlorinated water or sunlight may cause damage. An excessive amount of chlorine can break down the spandex of the swimwear. To avoid fading, you may want to soak the brand new swimsuit in water mixed with a little vinegar (about one tablespoon vinegar to a quart of water). This process helps the colors to set in and may delay fading.
Product care is entirely customer's responsibility and Elite Fashion Swimwear will not replace any product due to fading, discoloration, or other damage caused during wear.
We hope you enjoy your beautiful swimsuit for many years.
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Full Price merchandise is eligible for refund. Refunds incur a 5% restocking fee.
Discounted products (marked down, "On Sale", or discounted via promotions/coupons/deals) may be returned for exchange or store credit. No Refunds.
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text: Single malt whisky offers the greatest variation and depth of flavour of all spirits, despite being made from just barley, yeast and water. A single malt whisky must be produced at a single distillery, distilled from malted barley and water. The mash must be processed at the distillery and converted into a fermentable substrate using only endogenous enzyme systems and fermented only with the addition of yeast. The spirit must be aged for at least three years and one day and have nothing added to it save for water and spirit caramel. Whisky must be distilled to no more than 94.8% alcohol by volume and bottled at no less than 40%.


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The price for this vehicle as equipped does not include charges such as: License, Title, Registration Fees, State or Local Taxes, Finance Charges, Credit Investigation, Optional Credit Insurance, Physical Damage or Liability Insurance, Delivery Fees, or a negotiable $150 Documentary Fee. Any and all differences must be addressed prior to the sale of this vehicle.
Find a great sale price on this 2017 Buick Enclave Leather at Skagit Auto Center in Washington State. This 2017 Buick Enclave is located at our dealership in Burlington. We also serve the cities of Bellingham, Anacortes, and Mount Vernon. So if you're looking for a great price on this 2017 Buick Enclave Leather or just looking to get an auto loan for the vehicle you want... you've come to the right place! Skagit Auto Center.


text: Luxurious underwater living – Tunku Abdul Rahman Marine Park, Sabah ADD TO TRIP PLANNER REMOVE FROM TRIP PLANNER Named after Malaysia's first Prime Minister, this cluster of five islands – Gaya, Manukan, Mamutik, Sapi and Sulug – was gazetted as Sabah's second national park in 1974. Popular among divers and ecotourists, the park's relatively shallow waters are filled with an abundance of corals and aquatic species – perfect for snorkelling and diving for beginners. Each island features a different collection of flora and fauna, with Pulau Gaya being the largest and most colourful of the five. Must Do Go swimming, snorkelling or diving in the clear turquoise waters Indulge in a variety of watersports, such as parasailing and jet skiing Go island-hopping Who To Contact Phone: +6088-553 500 / 523 500 Fax: +6088-486 434 Visit website


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Texas Longhorns clogging the streets of Denver can only mean one thing: It's the kick-off parade for the annual National Western Stock Show & Rodeo.
The cattle joined with cowpokes, horses, floats, and marching bands from Union Station to amble 15 blocks down 17th Street on Thursday.
Mayor Michael Hancock is the grand marshal for the 2013 parade.
Holly Farmer, 45, of Denver, brought 9-year-old Avery and 7-year-old Daniel downtown to see the spectacle. The Farmer children attend Graland Country Day School.
"We are so excited," Farmer said. "Last year we came and we were a little late and we missed the longhorns. Today we came and we are going to be very excited. It's not too cold out here."
Avery was especially anxious to see the longhorns Thursday. "I like their horns," she said.
The show officially opens Saturday and runs through Jan. 27 at the National Western Complex at Interstate 70 and Brighton Boulevard.
More than 15,000 head of horses, cattle, sheep, swine, goats, llamas, alpacas, bison, yak, poultry and rabbits will make the grounds home during the show.
Overall attendance in 2012 was 636,663. The attendance record was set during the stock show's 100th anniversary in 2006 at 726,972.
Tom McGhee: 303-954-1671, email@example.com or twitter.com/dpmcghee


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JOB TITLE: Animal Care Assessor
LOCATION: Greater Manchester
SALARY: £16:00 – £18:00 per hour + statutory holiday pay
Exciting part time temporary opportunity – 1 day per week.
Are you ready for your next challenge in Further Education? Do you have a passion for education with plenty of enthusiasm to develop and inspire the next generation?
Protocol Assessment Services is pleased to be working alongside a leading Further Education provider to recruit for an experienced Animal Care Assessor.
This is a fantastic opportunity to pass on your skills at Further Education level and inspire the next generation. Working in a vibrant and positive learning environment, you will be responsible for assessing Animal Care up to level 3.
We are keen to hear from candidates that use innovative techniques to motivate and inspire learners.
Suitable candidates will meet the following criteria:
*Hold a relevant assessing qualification (Level 3 Assessing Certificate, TAQA or A1)
*Hold a minimum level 3 qualification in Animal Care
*Have experience assessing Animal Care up to level 3
*Have good organisational and planning skills.
*Plenty of enthusiasm and the ability to motivate learners.
*Willingness to provide outstanding support for learners
*Extensive knowledge of your subject area.
*Be flexible and self-motivated with a dedication to learner achievement and quality.
As a valued Protocol Assessment Services candidate, you will receive:
*The support of a highly experienced and dedicated Recruitment Consultant.
*Competitive rates of pay with no admin charges or hidden surprises.
*Candidate referral scheme
*Secure online profile where you can access timesheets, payslips and assignment details.
*Wide range of permanent and temporary job opportunities in over 250 Colleges and FE Providers across the UK.
If you have the skills and experience we require and you are looking for a new challenge please email your CV today. Not on the lookout for work but you know someone who is? Ask them to send us their CV.
Protocol Assessment Services is the leading provider of examination and assessment services and Assessor recruitment to the further education and employability sector. Our team of qualified Assessors, Internal and External Quality Assurers and Invigilators are based throughout the UK and are ready to provide assessment services across a varied range of subjects.
Since 2009 Protocol Assessment services has delivered tailored assessment services and Assessor recruitment to the sector ensuring that quality and flexibility of provision go hand in hand to ensure quality and value for money provision across the sector.
FE Jobs & College Jobs & FE Jobs & College Jobs & FE Jobs & College Jobs & FE Jobs & College Jobs


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Ethoxylation is a chemical process in which ethylene oxide is added to fatty acids to make them more soluble in water. An example of this process is the ethoxylation of sodium dodecyl sulfate to form sodium laureth sulfate (SLES) , often used in shampoos and toothpastes as a foaming agent. The problem with Ethoxylation is its use of a petrochemical called Ethylene Oxide, which generates 1,4-Dioxane as a by-product "known to the State of
1,4-Dioxane is commonly found in many conventional shampoos, body washes, lotions and other personal care and household cleaning products but a recent study commission by the Organic Consumers Association found this substance in many popular "natural" and "organic" brands. This same study found products certified by the USDA National Organic Program and the European BDIH foundation to be FREE of 1,4-Dioxane.
A copy of the Organic Consumer Association Consumer Alert on 1,4-Dioxane can be found here.
In a study conducted by the Campaign for Safe Cosmetics, 32 out of 48 children's skin care products tested positive for 1,4 Dioxane at levels of 0.27 to 35 ppm.


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|22fstops | profile | all galleries >> Senoia Raceway 2012 >> Senoia 7-7-12
|tree view | thumbnails | slideshow
Images in all galleries are available for purchase.
The photographs will ship ready for framing and on Canon or Kodak Professional Paper which with this paper you don't worry about prints fading. The standard is 100 years in home display and 200 years in dark storage from Kodak. Simply e-mail me at firstname.lastname@example.com or click on my name below to send an email with the photo number(s) and your shipping address.
All the best,
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text: Thursday, July 12, 2012 OAAA Lunch and Learn Series: Findings from Audience Research Hear Terry Brady, PhD, senior behavioral scientist at the Centers for Disease Control and Prevention, discuss lessons learned from audience research from primary care practices on July 18, noon to 12:30 pm, ET. Hosted by the Osteoarthritis Action Alliance (OAAA) as part of its Lunch and Learn series, Brady's presentation will focus on how the research was conducted, the key findings, recommendations, and putting the findings into action. Dial-in information and Brady's Powerpoint are available in this invitation from OAAA. APTA is a member of OAAA.


text: Pulau Payar Marine Park, Langkawi ADD TO TRIP PLANNER REMOVE FROM TRIP PLANNER The sprinkling of jade green islands that make up Pulau Payar lie just 30km south- east of Langkawi. From here, it is a 1-hour boat ride out to the best marine park on Malaysia's West Coast, making it an ideal choice for a day outing. This well-preserved, uninhabited marine park extends over a number of islands, with Pulau Payar being the largest. Your base out here is the floating platform moored off Pulau Payar. But the real attraction of this platform lies below sea level. Step into the underwater observation chamber to view the marine life surrounding a reef. Want to get even closer to the swirl of fishes that make these corals their home? Grab a mask, a snorkel and fins and join the spectacle! If you're into scuba diving, the best diving is along the reef system that skirts the south, east and west of Pulau Payar. Please check with your dive operator what the visibility is while you're there, as conditions vary. There is no accommodation in Pulau Payar as it is a marine park, but Langkawi, with all its fine resorts and restaurants, is just a speedy boat-ride away. Getting Here By Boat & CatamaranPulau Payar is just 30km south-east of Langkawi Island. You can get there from Kuah Jetty in Langkawi by speed boat or catamaran. The journey takes about 1 hour. Who To Contact Langkawi Tourist Information Centre Phone: +604-966 7789/5271 Fax: +604-966 7889 Related Brochure View all brochure


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Tapas + Sangria
Thirty something Mom-in-heels living a merely impractical life, shuttling between Dubai and the World. Fluent in Food, Travel & Style - in no particular order! Chasing adventures, one city at a time. Beginning with my home, the beautiful sandpit that is Dubai.
Al Hambra
Posted by Majeigh Vartzbed at 4:16 PM
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