text:
- Name
- Rituximab
- Accession Number
- Type
- Biotech
- Groups
- Approved
- Biologic Classification
- Protein Based Therapies
Monoclonal antibody (mAb)
- Description
Rituximab is a genetically engineered chimeric murine/human monoclonal antibody directed against the CD20 antigen found on the surface of normal and malignant B lymphocytes. The antibody is an IgG1 kappa immunoglobulin containing murine light and heavy-chain variable region sequences and human constant region sequences 6, Label. It was originally approved by the U.S. FDA in 1997 as a single agent to treat patients with B-cell Non-Hodgkin's Lymphoma (NHL) 8, however, has now been approved for a variety of conditions Label. On November 28, 2018, the US FDA approved Truxima, the first biosimilar to Rituxan (Rituximab) 7.
- Protein structure
- Protein chemical formula
- Protein average weight
- 143859.7 Da
- Sequences
>Rituximab heavy chain chimeric QVQLQQPGAELVKPGASVKMSCKASGYTFTSYNMHWVKQTPGRGLEWIGAIYPGNGDTSY NQKFKGKATLTADKSSSTAYMQLSSLTSEDSAVYYCARSTYYGGDWYFNVWGAGTTVTVS AASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQS SGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKAEPKSCDKTHTCPPCPAPELLG GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQY NSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRD ELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSR WQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
>Rituximab light chain chimeric QIVLSQSPAILSASPGEKVTMTCRASSSVSYIHWFQQKPGSSPKPWIYATSNLASGVPVR FSGSGSGTSYSLTISRVEAEDAATYYCQQWTSNPPTFGGGTKLEIKRTVAAPSVFIFPPS DEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTL SKADYEKHKVYACEVTHQGLSSPVTKSFNRGECDownload FASTA Format
- Rituximab - CAS 174722-31-7 [Link]
- Synonyms
- rituximab-abbs
- rituximab-pvvr
- External IDs
- Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing EndUnlock Additional Data Rituxan Solution 10 mg Intravenous Hoffmann La Roche 2000-03-20 Not applicable Rituxan Injection, solution 10 mg/1mL Intravenous Genentech, Inc. 1997-11-26 Not applicable Rituxan Injection, solution 10 mg/1mL Intravenous Genentech, Inc. 1997-11-26 Not applicable Rituxan Sc Solution Subcutaneous Hoffmann La Roche 2016-11-22 Not applicable Rituxan Sc Solution Subcutaneous Hoffmann La Roche 2018-04-24 Not applicable Ruxience Injection, solution 500 mg/50mL Intravenous Pfizer Laboratories Div Pfizer Inc 2020-01-23 Not applicable Ruxience Injection, solution 100 mg/10mL Intravenous Pfizer Laboratories Div Pfizer Inc 2020-01-23 Not applicable Truxima Injection, solution 10 mg/1mL Intravenous Cephalon, Inc. 2020-05-04 Not applicable Truxima Injection, solution 10 mg/1mL Intravenous Cephalon, Inc. 2020-05-04 Not applicable Truxima Solution 500 mg Intravenous Celltrion 2019-12-11 Not applicableAdditional Data Available
- Application NumberApplication Number
A unique ID assigned by the FDA when a product is submitted for approval by the labeller.Learn more
- Product CodeProduct Code
A governmentally-recognized ID which uniquely identifies the product within its regulatory market.Learn more
- Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Rituxan Hycela Rituximab (120 mg/1mL) + Hyaluronidase (2000 U/1mL) Injection, solution Subcutaneous Genentech, Inc. 2017-06-22 Not applicable Rituxan Hycela Rituximab (120 mg/1mL) + Hyaluronidase (2000 U/1mL) Injection, solution Subcutaneous Genentech, Inc. 2017-06-22 Not applicable
- International/Other Brands
- MabThera (Roche)
- Categories
- Amino Acids, Peptides, and Proteins
- Antibodies
- Antibodies, Monoclonal
- Antibodies, Monoclonal, Murine-Derived
- Antineoplastic Agents
- Antineoplastic Agents, Immunological
- Antirheumatic Agents
- Biologics for Rheumatoid Arthritis Treatment
- Blood Proteins
- CD20-directed Antibody Interactions
- CD20-directed Cytolytic Antibody
- Globulins
- Immunoglobulins
- Immunologic Factors
- Immunoproteins
- Immunosuppressive Agents
- Myelosuppressive Agents
- Narrow Therapeutic Index Drugs
- Proteins
- Serum Globulins
- CAS number
- 174722-31-7
- Indication
Rituximab is indicated in the following conditions Label:
Non–Hodgkin's Lymphoma (NHL)
Chronic Lymphocytic Leukemia (CLL)
Rheumatoid Arthritis (RA) in combination with methotrexate in adult patients with moderately-to severely-active RA
Granulomatosis with Polyangiitis (GPA) (Wegener's Granulomatosis) and Microscopic Polyangiitis (MPA)
Moderate to severe Pemphigus Vulgaris (PV) in adult patients
The biosimilar (approved in November 2018), Truxima, is indicated For the treatment of adult patients with CD20-positive, B-cell non-Hodgkin's lymphoma (NHL) to be used as a single agent or in combination with chemotherapy 7.
In September 2019, the rituximab injection was approved along with glucocorticoids to manage granulomatosis with polyangiitis (GPA) in addition to microscopic polyangiitis (MPA) in children of at least 2 years of age 9.
- Associated Conditions
- Chronic Lymphocytic Leukaemia (CLL)
- Granulomatosis With Polyangiitis
- Granulomatosis With Polyangiitis (GPA)
- Microscopic Polyangiitis
- Microscopic Polyangiitis (MPA)
- Non-Hodgkin's Lymphoma (NHL)
- Pemphigus Vulgaris (PV)
- Moderate Rheumatoid arthritis
- Moderate to severe pemphigus vulgaris
- Severe Rheumatoid arthritis
- Pharmacodynamics
Rituximab binds to the CD20 antigen, which is predominantly expressed on mature B cells and on >90% of B-cell non-Hodgkin's lymphomas 1. The antibody leads to selective killing of B-cells. The following are the pharmacodynamic outcomes for various conditions, including non- Hodgkin's Lymphoma Label:
Non-Hodgkin's Lymphoma (NHL) In Non-Hodgkin's Lymphoma patients, the administration of rituximab led to the depletion of circulating and tissue-based B cells. Among 166 patients in Study 1, circulating CD19-positive B cells were depleted within the first three weeks, showing sustained depletion for up to 6-9 months post-treatment in 83% of treated patients. B-cell recovery began at approximately 6 months and median B-cell levels returned to normal by 12 months following the completion of treatment Label. There were sustained and statistically significant decreases in serum IgM and IgG levels measured from 5-11 months following rituximab administration; 14% of patients showed IgM and/or IgG serum levels below the normal range Label.
Rheumatoid Arthritis In rheumatoid arthritis (RA) patients, treatment with rituximab induced the depletion of peripheral B lymphocytes, with the majority of patients showing near complete depletion (CD19 counts below the lower limit of quantification, 20 c-lls/μl) within 2 weeks after the first dose of rituximab. The majority of treated patients showed peripheral B-cell depletion, sustained for a minimum of 6 months. A small percentage of patients (~4%) had peripheral B-cell depletion that was sustained for more than 3 years after one course of treatment. Total serum immunoglobulin levels, IgM, IgG, and IgA were decreased at 6 months with the greatest change observed in IgM. At Week 24 of the first cycle of rituximab treatment, small percentages of patients experienced decreases in IgM (10%), IgG (2.8%), and IgA (0.8%) levels below the lower limit of normal (LLN). When rituximab was administered to RA patients during repeated rituximab treatment, 23.3%, 5.5%, and 0.5% of patients experienced decreases in IgM, IgG, and IgA concentrations below LLN at any time after receiving rituximab, respectively. The clinical consequences of decreases in immunoglobulin levels in RA patients treated with rituximab are not clear at this time. Treatment with rituximab in patients with RA was associated with a decreased level of several biologic markers of inflammation such as interleukin-6 (IL-6), C-reactive protein (CRP), serum amyloid protein (SAA), S100 A8/S100 A9 heterodimer complex (S100 A8/9), anti-citrullinated peptide (anti-CCP), and RF Label and was found to decrease disease symptoms 2.
Granulomatosis with Polyangiitis (GPA) (Wegener's Granulomatosis) and Microscopic Polyangiitis In GPA and MPA patients, peripheral blood CD19 B-cells were depleted to less than 10 cells/μl after the first two infusions of rituximab, and remained at the same level in most (84%) patients through Month 6 of the treatment. By Month 12, most patients (81%) demonstrated signs of B-cell return with counts >10 cells/μL. By Month 18, the majority of patients (87%) had counts >10 cells/μL Label.
- Mechanism of action
Rituximab is a monoclonal antibody that targets the CD20 antigen, which is expressed on the surface of pre-B and mature B-lymphocytes 1, 2, 3, Label. After binding to CD20, rituximab mediates B-cell lysis (or breakdown). The possible mechanisms of cell lysis include complement dependent cytotoxicity (CDC) and antibody dependent cell-mediated cytotoxicity (ADCC) Label.
Rituximab belongs to the immunoglobulin G1 (IgG1) sub-class, consisting of a murine variable region (Fab region) and a human constant region (Fc region). The Fab region has variable sections that define a specific target antigen, allowing the antibody to attract and secure its exclusive antigen, specifically the binding of rituximab (IgG1) to CD20 on pre-B and mature B lymphocytes. The Fc region is the tail end of the antibody that communicates with cell surface receptors to activate the immune system, in this case, a sequence of events leading to the depletion of circulating B lymphocytes by complement-dependent cell lysis, antibody-dependent cellular cytotoxicity, as well as apoptosis 6.
In regards to the mechanism of action in rheumatoid arthritis, B cells are thought to play a role in the pathogenesis of rheumatoid arthritis (RA) and the associated condition of chronic synovitis. B cells may act at various sites in the autoimmune/inflammatory process, including through production of rheumatoid factor (RF) and other autoantibodies, antigen presentation, T-cell activation, and/or the production of proinflammatory cytokines Label. The administration of rituximab in this condition has been shown to result in significant clinical and symptomatic improvements 2, Label.
Target Actions Organism AB-lymphocyte antigen CD20antibody Humans
- Absorption
Following the administration of 2 doses of rituximab in patients with rheumatoid arthritis (RA), the mean (± S.D.; % CV) concentrations after the first infusion (Cmax first) and second infusion (Cmax second) were : 157 ( ± 46; 29%) and 183 ( ± 55; 30%) mcg/mL, and 318 ( ± 86; 27%) and 381 ( ± 98; 26%) mcg/mL for the 2 × 500 mg and 2 × 1000 mg doses, respectively Label.
- Volume of distribution
3.1 L in Rheumatoid Arthritis Label
4.5 L in Granulomatosis with polyangitis and microscopic polyangitis Label
- Protein binding
- Not Available
- Metabolism
Most likely removed by opsonization via the reticuloendothelial system 5.
- Route of elimination
Likely eliminated through the reticuloendothelial system 5.
- Half life
Non-Hodgkin's Lymphoma: Based on a population pharmacokinetic analysis of data from 298 Non-Hodgkin's Lymphoma (NHL) patients who received rituximab once weekly or once every three weeks, the estimated median terminal elimination half-life was 22 days (range, 6.1 to 52 days) Label.
Rheumatoid Arthritis: Mean terminal elimination half-life was 18.0 days in patients with rheumatoid arthritis Label Based on a population pharmacokinetic analysis of data from 2005 RA patients who received rituximab Label.
Chronic Lymphocytic Leukemia (CLL): Pharmacokinetics were studied in 21 patients with CLL receiving rituximab according to the recommended dose and schedule. The estimated median terminal half-life of rituximab was 32 days (range, 14-62 days) Label.
Granulomatosis with Polyangitis and Microscopic Polyangitis: Based on the population pharmacokinetic analysis of data in 97 GPA and MPA patients who received 375 mg/m2 rituximab once weekly by intravenous infusion for four weeks, the estimated median terminal elimination half-life was 23 days (range, 9 to 49 days) Label.
- Clearance
Rheumatoid Arthritis: 0.335 L/day Label
Granulomatosis with Polyangitis and Microscopic Polyangitis: 0. 312 L/day Label
Patients with higher CD19-positive cell counts or larger measurable tumor lesions at pretreatment had a higher clearance Label.
- Toxicity
Oral LD50: 27 mg/kg (mouse and rat) MSDS
Inhalation LD50: 32 mg/m3 (mouse) and 37 mg/m3 (rat) MSDS
Skin LD50: 20 mg/kg (rabbit) and 50 mg/kg (rat) MSDS
Carcinogenesis, Mutagenesis, Impairment of Fertility No long-term animal studies have been performed to establish the carcinogenic or mutagenic potential of rituximab or to determine potential effects on fertility in males or females Label.
Embryo-Fetal toxicity: Can cause neonatal harm. Advise of potential risk to neonates and use of effective contraception Label.
- Affected organisms
- Humans and other mammals
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
Interacting Gene/Enzyme Allele name Genotype(s) Defining Change(s) Type(s) Description Details Low affinity immunoglobulin gamma Fc region receptor III-A FCGR3A (G;G) / (G;T) T > G Effect Directly Studied Patients with this genotype have increased frequency of anti-tumor response when using rituximab to treat diffuse large B-cell lymphoma, follicular lymphoma, or [follicular non-Hodgkin lymphoma]. Details
Comprehensive structured data on known drug adverse effects with statistical prevalence. MedDRA and ICD10 ids are provided for adverse effect conditions and symptoms.Learn more
Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.Learn more
Structured data representing warnings from the black box section of drug labels. These warnings cover important and dangerous risks, contraindications, or adverse effects.Learn more
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug InteractionUnlock Additional Data (R)-warfarin The risk or severity of bleeding can be increased when (R)-warfarin is combined with Rituximab. (S)-Warfarin The risk or severity of bleeding can be increased when (S)-Warfarin is combined with Rituximab. 2-Methoxyethanol The risk or severity of adverse effects can be increased when Rituximab is combined with 2-Methoxyethanol. 4-hydroxycoumarin The risk or severity of bleeding can be increased when 4-hydroxycoumarin is combined with Rituximab. 9-(N-methyl-L-isoleucine)-cyclosporin A The risk or severity of adverse effects can be increased when Rituximab is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A. Abatacept Rituximab may increase the immunosuppressive activities of Abatacept. Abciximab The risk or severity of adverse effects can be increased when Abciximab is combined with Rituximab. Abetimus The risk or severity of adverse effects can be increased when Rituximab is combined with Abetimus. Abituzumab The risk or severity of adverse effects can be increased when Rituximab is combined with Abituzumab. Abrilumab The risk or severity of adverse effects can be increased when Rituximab is combined with Abrilumab.Additional Data Available
- Extended DescriptionExtended Description
Extended description of the mechanism of action and particular properties of each drug interaction.Learn more
- SeveritySeverity
A severity rating for each drug interaction, from minor to major.Learn more
- Evidence LevelEvidence Level
A rating for the strength of the evidence supporting each drug interaction.Learn more
- ActionAction
An effect category for each drug interaction. Know how this interaction affects the subject drug.Learn more
- Food Interactions
- Not Available
- General References
- McLaughlin P, Grillo-Lopez AJ, Link BK, Levy R, Czuczman MS, Williams ME, Heyman MR, Bence-Bruckler I, White CA, Cabanillas F, Jain V, Ho AD, Lister J, Wey K, Shen D, Dallaire BK: Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: half of patients respond to a four-dose treatment program. J Clin Oncol. 1998 Aug;16(8):2825-33. [PubMed:9704735]
- Edwards JC, Szczepanski L, Szechinski J, Filipowicz-Sosnowska A, Emery P, Close DR, Stevens RM, Shaw T: Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis. N Engl J Med. 2004 Jun 17;350(25):2572-81. [PubMed:15201414]
- Braendstrup P, Bjerrum OW, Nielsen OJ, Jensen BA, Clausen NT, Hansen PB, Andersen I, Schmidt K, Andersen TM, Peterslund NA, Birgens HS, Plesner T, Pedersen BB, Hasselbalch HC: Rituximab chimeric anti-CD20 monoclonal antibody treatment for adult refractory idiopathic thrombocytopenic purpura. Am J Hematol. 2005 Apr;78(4):275-80. [PubMed:15795920]
- Binder M, Otto F, Mertelsmann R, Veelken H, Trepel M: The epitope recognized by rituximab. Blood. 2006 Sep 15;108(6):1975-8. Epub 2006 May 16. [PubMed:16705086]
- Ryman JT, Meibohm B: Pharmacokinetics of Monoclonal Antibodies. CPT Pharmacometrics Syst Pharmacol. 2017 Sep;6(9):576-588. doi: 10.1002/psp4.12224. Epub 2017 Jul 29. [PubMed:28653357]
- Emer JJ, Claire W: Rituximab: a review of dermatological applications. J Clin Aesthet Dermatol. 2009 May;2(5):29-37. [PubMed:20729962]
- FDA approves first biosimilar for treatment of adult patients with non-Hodgkin's lymphoma [Link]
- FDA Approves Two New Indications for Rituxan in Patients With Non-Hodgkin's Lymphoma [Link]
- FDA approves first treatment for children with rare diseases that cause inflammation of small blood vessels [Link]
- External Links
- UniProt
- Genbank
- PubChem Substance
- 46505820
- RxNav
- 121191
- ChEMBL
- Therapeutic Targets Database
- PharmGKB
- RxList
- RxList Drug Page
- Drugs.com
- Drugs.com Drug Page
- Wikipedia
- Rituximab
- ATC Codes
- L01XC02 — Rituximab
- AHFS Codes
- 10:00.00 — Antineoplastic Agents
- FDA label
- Download (257 KB)
- Download (117 KB)
Clinical Trials
- Clinical Trials
- Manufacturers
- Roche
- Packagers
- Biogen Idec Inc.
- F Hoffmann-La Roche Ltd.
- Genentech Inc.
- Dosage forms
Form Route Strength Injection, solution Intravenous 10 mg/1mL Solution Intravenous 10 mg Injection, solution Subcutaneous Solution Subcutaneous Injection, solution Intravenous 100 mg/10mL Injection, solution Intravenous 500 mg/50mL Solution Intravenous 100 mg Solution Intravenous 500 mg
- Prices
Unit description Cost Unit Rituxan 10 mg/ml Concentrate 10ml Vial 708.17USD vial Rituxan 10 mg/ml vial 68.09USD mlDrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
- Patents
Patent Number Pediatric Extension Approved Expires (estimated)Unlock Additional Data CA2149329 No 2008-07-15 2013-11-12 CA1336826 No 1995-08-29 2012-08-29 US5736137 No 1998-04-07 2015-04-07Additional Data Available
- Filed OnFiled On
The date on which a patent was filed with the relevant government.Learn more
- State
- Liquid
- Experimental Properties
Property Value Source melting point (°C) 61 °C (FAB fragment) http://crdd.osdd.net/raghava/thpdb/display_thppid_sub.php?details=Th1062 hydrophobicity -0.414 http://crdd.osdd.net/raghava/thpdb/display_thppid_sub.php?details=Th1062 isoelectric point 8.68 http://crdd.osdd.net/raghava/thpdb/display_thppid_sub.php?details=Th1062
- Description
- Not Available
- Kingdom
- Organic Compounds
- Super Class
- Organic Acids
- Class
- Carboxylic Acids and Derivatives
- Sub Class
- Amino Acids, Peptides, and Analogues
- Direct Parent
- Peptides
- Alternative Parents
- Not Available
- Substituents
- Not Available
- Molecular Framework
- Not Available
- External Descriptors
- Not Available
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- Antibody
- General Function
- Mhc class ii protein complex binding
- Specific Function
- This protein may be involved in the regulation of B-cell activation and proliferation.
- Gene Name
- Uniprot ID
- Uniprot Name
- B-lymphocyte antigen CD20
- Molecular Weight
- 33076.99 Da
- Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352]
- van Meerten T, Hagenbeek A: CD20-targeted therapy: the next generation of antibodies. Semin Hematol. 2010 Apr;47(2):199-210. doi: 10.1053/j.seminhematol.2010.01.007. [PubMed:20350667]
- Jaglowski SM, Byrd JC: Rituximab in chronic lymphocytic leukemia. Semin Hematol. 2010 Apr;47(2):156-69. doi: 10.1053/j.seminhematol.2010.01.005. [PubMed:20350663]
- McLaughlin P, Grillo-Lopez AJ, Link BK, Levy R, Czuczman MS, Williams ME, Heyman MR, Bence-Bruckler I, White CA, Cabanillas F, Jain V, Ho AD, Lister J, Wey K, Shen D, Dallaire BK: Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: half of patients respond to a four-dose treatment program. J Clin Oncol. 1998 Aug;16(8):2825-33. [PubMed:9704735]
- Rituxan FDA label [File]
Drug created on June 13, 2005 07:24 / Updated on May 28, 2020 03:59


text:
So I gotta write 2014 on these things now? What's up with THAT?
I would have just killed him.
But then again, I'm not very patient. Kill the dude, get a pizza. That's my motto.
It's a good motto.
I gotta say, this was less complicated for BitchRayVal than I expected.
Perhaps will introduce some difficulty to the sitch.
Stupid SQL injection defense: super effective vs literary license.
"Perhaps "hulk smash" will introduce some difficulty to the sitch."

subset: commoncrawl


text:
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text:
Intervention was not politically beneficial for anyone in the US government, while the invasions in the Middle East/bombings elsewhere etc. were. While people framed the invasions as humanitarian, if that were true, the Darfur situation was far more important and dire than the ones in the Middle East, though nobody wanted to help.
Unfortunatley, the United States failed Darfur and didn't provide enough support to the region. The tragedies that occurred in Darfur could have been avoided if we had taken a more proactive approach to preventing such tragedies. With that in mind, the U.S. should be severely reprimanded for its inaction today.
Yes, the U.S. should have done more for Darfur, because the situation was drastic. In Darfur, there was a great loss of human life, including non-militant women, children, and even men. The U.S. probably did not intervene because we do not have natural resource interests in the region. But it was a human tragedy that deserved our intervention.
Helping Darfur was not politically beneficial to the US, so there had been no reason to help the country - even though the Iraq issue was done, ostensibly, for moral reasons. While the moral case for helping the Iraqi people is sound, certainly, the same argument can be made for Darfur, there just wasn't enough to go around.
Although the genocide at Dafur was a tragedy, the US was not responsible for stopping it. The former colonial powers of Europe who cause the ethnic conflict in Africa should have intervened to stop the violence. The United States was not responsible for Darfur, and we were not required to do anything.


text:
Fall Indie Film Preview
Posted by Stephen Saito on
Prepare to see stars in your local arthouse as the summer turns to fall. Brad Pitt, Charlize Theron, Drew Barrymore will all grace celluloid in the coming months. There are new films from star directors — Tarantino! Campion! Soderbergh! Coen brothers! Even the new documentaries are driven by stars — Michael Moore's "Capitalism: A Love Story," LeBron James' "More Than a Game" and Anna Wintour's "The September Issue." And then, as Matt Singer will tell you, there are breakout stars who you should start catching up with now. In between, there's epic animation ("Ponyo" and "9"), an astounding array of asskicking ("Ong Bak 2" and "Black Dynamite") and Lars von Trier's "Antichrist," proving there's there's just about something for everyone this fall at the multiplex. (And if not there, make sure to check out what films you can catch in the comfort of your own home on demand, online, and on DVD and at your local repertory theater.)
August 7
The Cast: Charlyne Yi, Jake Johnson, Michael Cera
Director: Nicholas Jasenovec
Fest Cred: Sundance, Seattle, Los Angeles
The Gist: As hard as it is to define Yi's unique brand of humor (which she deftly applied as the lone female in the "Knocked Up" animal house), it might be even harder to describe the romantic comedy in which she plays herself as a woman who doesn't believe in love, featuring real woman-on-the-street interviews with successful couples while she starts a relationship with her (maybe) real-life boyfriend Michael Cera. The hybrid of woman-on-the street interviews, handmade dioramas and injections of narrative interludes earned Yi and co-writer/director Jasenovec the Waldo Salt screenwriting prize at this year's Sundance.
The Cast: Maggie Hatcher, Tilly Hatcher, Alex Karpovsky, Katy O'Connor
Writer/Director: Andrew Bujalski
Fest Cred: Berlinale, SXSW, Buenos Aires
The Gist: "Mutual Appreciation" director Bujalski continues to make a personal travelogue of places he's lived with this Austin-set story of twin sisters who find themselves simultaneously in a rut in their professional and personal lives.
The Cast: Talat Bulut, Özgü Namal, Murat Han, Mustafa Avkiran
Director: Abdullah Oguz
Fest Cred: Copenhagen, Vancouver, Cleveland
The Gist: Based on Zülfü Livaneli's novel of the same name, this Turkish thriller stars Namal as a 17-year-old girl whose family approves an honor killing after fearing her chastity's been taken and recruits a distant cousin to carry out the act during a long boat trip, only things get complicated when the cousin starts to have feelings for her.
"By the People: The Election of Barack Obama"
Directors: Amy Rice and Alicia Sams
The Gist: Rice and Sams started rolling their cameras on the then-Illinois senator in 2006 before he announced his candidacy for the presidency and subsequently got hundreds of hours of behind the scenes footage from the historic campaign. Bankrolled by Edward Norton, Sony and HBO are taking the doc out for a one-week awards qualifying run in Los Angeles before a full theatrical release later this fall.
"Cloud 9"
The Cast: Ursula Werner, Horst Rehberg, Horst Westphal
Director: Andreas Dresen
Fest Cred: Cannes, Munich, Karlovy Vary, Toronto, Berlinale
The Gist: Fitting alongside nicely with Paul Cox's 2000 sexually charged septuagenarian romance "Innocence," Dresen's drama stars Werner as a 67-year-old clothier who finds her passion reignited during a torrid affair with an 76-year-old widower. The film arrives in America after winning a slew of awards abroad, beginning with its Un Certain Regard Prize at Cannes in 2008 and German Film Awards for Werner as best actress and Dresen as best director.
"Cold Souls"
The Cast: Paul Giamatti, Dina Korzun, Emily Watson, David Strathairn, Katheryn Winnick, Lauren Ambrose
Writer/Director: Sophie Barthes
Fest Cred: Sundance, Cannes, Seattle, Los Angeles, Sydney
The Gist: Don't call it a Charlie Kaufman movie, but Sophie Barthes' feature directorial debut enters into some similar metaphysical territory with Giamatti starring as a self-important version of himself who discovers a doctor (Straithairn) that can remove and store souls for safe keeping.
"El Tinte De La Fama"
The Cast: Elaiza Gil, Alberto Alifa, Mirtha Borges, Miguel Ferrari
Director: Alejandro Bellame Palacios
The Gist: Last year's Venezuelan Oscar entry is Palacios' feature debut, a surrealist plunge into the intoxicating waters of stardom, following a blond beauty who's egged on by husband to enter a televised Marilyn Monroe look-a-like contest. Her fragile psyche begins to fracture as events in her life begin to oddly mirror those of the real Monroe.
"I Sell the Dead"
The Cast: Dominic Monaghan, Ron Perlman, Larry Fessenden, Angus Scrimm
Writer/Director: Glenn McQuaid
Fest Cred: Sitges, Slamdance, Glasgow, Rotterdam, Glasgow, Seattle
The Gist: A throwback to the Hammer films of the '60s that opened this year's Slamdance Film Festival, this black comedy stars Fessenden and Monaghan as a pair of grave robbers whose adventures with shovels are chronicled shortly before they get the axe.
"12 in a Box"
The Cast: Brian Mitchell, Anjella Mackintosh, Kenneth Collard, Katy Wix, Paul Williamson, Clare Welch
Writer/Director: John McKenzie
Fest Cred: Berlinale, Boston, Zurich
The Gist: Though it's advertised as a comedy, this British import might seem more like a terrifying version of "Big Brother" where a dozen former classmates reunite for a weekend in the country and are propositioned to stay 96 hours without leaving the premises in order to win a million pounds. Enough hijinks ensue to make the guests think about changing their friends on Facebook.


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festivals tagged posts
It can be a gamble whipping out your camera or phone during Songkran but these people were prepared to risk the ruination of their photography equipment to capture the watery madness that is New Year in Thailand. We in turn jeopardised damaging our third camera in Southeast Asia to photograph them doing so.Read More
We have mixed feelings about Songkran, in that one of us loves charging about town squirting water into the faces of old women and children, while the other loathes it and won't venture outside for the duration.Read More
Generator's Summer of Festivals is back for a second year. They are offering the chance to win a job as their Summer of Festivals Reporter and spend the summer travelling around Europe covering music festivals and documenting them on Generator's blog and social channels.Read More
There's a festival out there now for everyone and everything, from cheese rolling to high-end fashion to conventions celebrating everything geeky. So which ones should you be putting in your diary this year and waking up at 6am on ticket sale day to get into? These are five festivals you absolutely must go to!Read More
Applications for volunteering with Croatia's Outlook Festival are now open. In return for helping out volunteers will receive a free festival ticket (normally £140), food tokens and four nights' refunded camping.Read More
You're armed to the teeth with the biggest water gun you could find and ready for some watery mayhem but want to make the most of what might be a once in life time experience. The great thing about Songkran is it is for everyone: young and old, male or female, Thai or tourist, everyone has a laugh and enjoys themselves. Here is our guide to the polite mayhem Thais call Songkran. Read More
For myself and most other farang Songkran is about running around town assaulting old women and children - and everyone in between - with the biggest water gun money can buy. Read More
After the mayhem of Songkran I started to look around for another crazy festival to attend and the rocket festival celebrated by Lao peoples in Laos and northeastern Thailand fitted the bill perfectly.Read More
If you have kept up with our Facebook updates you will know we have spent the past few days charging around Chiang Mai with a water gun, randomly or deliberately squirting people - young and old alike - in the face.Read More
I'm sitting in a pink towel (actually, it's puce; yes, definitely puce) listening to the whoops and cheers as our neighbours soak each other and passing scooters with water. On the bed are laid out various items of clothing. What does one choose from our limited wardrobe for charging about town like a maniac squirting people in the face?Read More


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|Kenneth Shelley, Ashley Kung, J.M. Frey, Me
A short one for today, but no less fabulous. I realise that the internet is international, but I thought I should share some links for my fellow Canadians who were beginning to get interested in Steampunk.
When I was manning the Steampunk table at FanExpo a lot of people were curious exactly how one met other Steampunk people. What one did with the Steampunk. Granted yes, people make Steampunk things and sell Steampunk things, but there are also social gatherings of Steampunkers that happen on a regular basis. Again, I can only speak to some of the Canadian ones, but if anyone has knowledge of any others in other parts of the world please do share in the comments section below.
Steampunk Canada
Probably the most comprehensive listing for Steampunk activities across Canada.
Toronto Steampunk Society
Specifically for those Steampunkers in Toronto, there are many scheduled events in the city - walks, photoshoots, pub gatherings - and this page is actively updated every day.
Steampunk Ottawa
Similar to the TSS. Only if you, you know, live in Ottawa.
And don't forget about MeetUp.com, where you can search for any events happening in your region, and can totally use the keyword "Steampunk".


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by Natasha Preston
Narrated by : Dawn Murphy, Nicholas Camm, Richard Dadd
Series: The Cellar #1
Published by Audible Studios Release date : March 28th 2014
Genres: Young Adult
Source: Purchased | Format: Audiobook
Purchase at: Amazon (Affiliate Link) • Audible • Barnes & Noble
When sixteen-year-old Summer Robinson goes missing one night, her family, friends and boyfriend are devastated. Nothing ever happens in Long Thorpe, so the disappearance of a school girl shocks the whole community. The police waste no time in launching a search and investigation, but with nothing to go on and no trace of Summer, hopes of finding her quickly fade.
Colin Brown, is a thirty-year-old solicitor living alone after the death of his mother. He suffered a traumatic and abusive childhood, and is left with no sense of right or wrong. Desperate for the perfect family, Colin, referring to himself as Clover, turns to drastic measures to get what he wants.
My Thoughts
I snagged up The Cellar while browsing for something different on Audible. It seems like I get stuck in a pattern with my audiobooks and I wanted to branch out and read something different. The Cellar, is my kind of book, so it was an easy decision to make.
Told in multiple POVs and with flash backs, The Cellar followers Summer from the moment she is kidnapped and placed in a cellar with three other girls. We get flashbacks scenes with her and her boyfriend, Lewis; Lewis' POV as he searches for Summer and we even get a good look inside the mind of the one who kidnapped Summer, Colin/Clover.
Summer was a fighter until the end. Sometimes, it's hard to understand why people do and say the things they do in certain situations and I had to remind myself that her situation was well, scary, horrific and disturbing, and I had no way of knowing how I personally would react. The other girls in the cellar had been there for a while, and their co-dependency was hard to witness. What they are put through is horrible.
I thought the book pieced itself together well. For a lot of the book, we don't know what Colin/Clover motivation for what he does and it slowly comes together as the book progresses; with more scenes from his POV.
The Narrator
I am so happy that there were three different narrators for each POV. Sometimes, it can work with just one narrator but it was necessary for The Cellar and I am glad it was executed that way. All three are new-to-me narrators and I thought they did a great job. One one small peeve was how SLOW Dawn read. There were times when the flow was choppy because of it.
I didn't realize that The Cellar had a sequel and while I really liked it, I won't be reading it. I love where The Cellar ended. Overall, I really liked it!
[divider]Now That You're Here
by Amy K. Nichols
Series: Duplexity #1
Published by Knopf Books for Young Readers Release date : December 9th 2014
Genres: Romance, Young Adult, Science Fiction
Format: Hardcover
In a parallel universe, the classic bad boy falls for the class science geek.
One minute Danny was running from the cops, and the next, he jolted awake in an unfamiliar body - his own, but different. Somehow, he's crossed into a parallel universe. Now his friends are his enemies, his parents are long dead, and studious Eevee is not the mysterious femme fatale he once kissed back home. Then again, this Eevee - a girl who'd rather land an internship at NASA than a date to the prom--may be his only hope of getting home.
Eevee tells herself she's only helping him in the name of quantum physics, but there's something undeniably fascinating about this boy from another dimension... a boy who makes her question who she is, and who she might be in another place and time.
My Thoughts
Quite honestly, I hadn't heard of this one until I was asked to review the second book, While You Were Gone. Which is a shame, because I would have snagged this one up right away before!
Alternate dimensions/parallel universes has always been a fascination of mine. I don't/can't follow the ALL science aspects in most of them, mainly because it goes straight over my head. So I loved how light Now That You're Here was. Meaning, she did an amazing job weaving together the story and the science without having
the reader, ME, scratching my head in confusion.
Imagine finding yourself in a different world, where your parents are dead, your friends aren't what they seem and the world around you is completely different? That is what happens to Danny. Thrown from his universe to Eevee's.
While this was on the shorter side, it packed a thought-provoking punch and never let up on the action. Eevee questions who she is in her world and what she would/could be like in another, while Danny's thoughts are consumed with his undecided thoughts on if he wants to return to his own universe.
The romance is on the lighter side – but it drives both characters. It's enjoyable and sweet, and I loved its development. I appreciate the ending, because well.. spoiler. ha!
All in all – I liked it!
Tell me your thoughts
- Have you read either of these books? If so, what did you think?
- If not, do either one sound like something you'd enjoy?
Tonyalee is an avid reader, gym junkie, coffee addicted workaholic, and blogger. Be sure to follow on Twitter, Facebook & Instagram for random shenanigans.


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Number 6 in a series
A Facebook friend from time to time posts links to the Discovery Institute's Evolution News blog. Much thanks. I need to keep up.
Evolution News has a number of authors, mostly notable creationists. These would include Stephen C. Meyer, Michael Behe, John West, and Jonathan Wells. This item was posted by Ann Gauger:
Ann Gauger is a zoologist with a BS in biology from MIT and a 1989 PhD from the University of Washington. As a post-doctoral fellow at Harvard she cloned and characterized the Drosophila kinesin light chain. Her research has been published in Nature, Development, and the Journal of Biological Chemistry. She also has a number of years of experience as a homeschool teacher.
From Evolution News:
Is There a First Human Couple in Our Past? New Evidence and Arguments
Dennis Venema is associate professor at Trinity Western University. His book Adam and the Genome is under active discussion here and over at BioLogos. The central question implied in the title of that book is: does our genome rule out Adam? Could humanity have had its origin in a first pair, or did it have to come from a population of at least several thousand?
This question has been addressed by numerous scientists in the past, ever since human genetic data began to roll in. And all of them, as far as I know, have said that yes, our genome rules out Adam. We are the product of common descent. We are descended from an ape-like population of at least several thousand. This we have heard before.
Now here's where it gets interesting. There has been a debate going on over at BioLogos for a number of months that was triggered by Venema's book. The debate is about whether there could have been a bottleneck of two at some time in the human past. This discussion was started when Richard Buggs, Senior Research Leader (Plant Health) at Royal Botanic Gardens Kew, and Reader in Evolutionary Genomics at Queen Mary, University of London, challenged Dennis Venema about what Venema wrote in Adam and the Genome. Venema had argued:
As our methodology becomes more sophisticated and more data are examined, we will likely further refine our estimates [of human population size] in the future. That said, we can be confident that finding evidence that we were created independently of other animals or that we descend from only two people just isn't going to happen. Some ideas in science are so well supported that it is highly unlikely new evidence will substantially modify them, and these are among them. The sun is at the center of our solar system, humans evolved, and we evolved as a population.
Put most simply, DNA evidence indicates that humans descend from a large population because we, as a species, are so genetically diverse in the present day that a large ancestral population is needed to transmit that diversity to us. To date, every genetic analysis estimating ancestral population sizes has agreed that we descend from a population of thousands, not a single ancestral couple. Even though many of these methods are independent of each other, all methods employed to date agree that the human lineage has not dipped below several thousand individuals for the last three million years or more — long before our lineage was even remotely close to what we would call "human." Thus the hypothesis that humans descend solely from one ancestral couple has not yet found any experimental support — and it is therefore not one that geneticists view as viable. [Emphasis added.]
The image above appears at the head of Gauger's Evolution News posting. It's a painting from centuries ago titled "Adam and Eve" or something close to that.
I have previously reviewed the book Adam and the Genome by Dennis R. Venema and Scot McKnight. The summary of the book is that the creationists have it all wrong, the human species did not descend from a single pair of humans, but is the most recent of a lineage stretching back billions of years. However, God does exist, and God is responsible for all this.
Update: I am adding some material of interest.
Gauger mentions she has previously discussed this point.
So TSP is not validated for these highly polymorphic genes, HLA-DRB1 in particular, and convergent evolution (or original diversity) is validated. I addressed, by the way, the question of HLA-DRB1's polymorphism and TSP, and a first human pair, in the book Science and Human Origins (2012). That book was written after I discovered that Francisco Ayala's argument against the possibility of a first pair based on HLA-DRB1 did not stand up. My hypothesis about a first pair was based on what I saw in papers about HLA-DRB1, most notably this and this, but the hypothesis was more suggested than demonstrated. I am glad to see that some of what I wrote has been substantiated.
See below for an expansion of TSP. The book in question has five parts, written separately by Gauger, Douglas Axe, and Casey Luskin. Gauger contributed chapters 1 and 5. Chapter 5 relates to the topic of her posting:
Ann Gauger
Using population genetics, some scientists have argued that there is too much genetic diversity to have passed through a bottleneck of just two individuals. But that turns out not to be true.
IN CHAPTER 1, I ARGUED THAT OUR SIMILAR ANATOMY AND DNA sequences are not sufficient to demonstrate that we share a common ancestor with chimps. Using peer-reviewed scientific literature about transitional fossils, and what is known about current chimp and human anatomy, I concluded that there are too many anatomical changes and too little time for neo-Darwinian processes to have accomplished the supposed transition from our last common ancestor with chimps to us.
But the current challenge concerning our origins involves more than fossils, anatomy, and improbable Darwinian scenarios. Now that DNA sequencing has become relatively simple and cheap, researchers are gathering vast amounts of human sequence data. They use the genetic variation they find to reconstruct past events in our genetic history. They derive evolutionary trees, estimate ancestral population sizes, and even calculate when and where our ancestors migrated out of Africa. Based on this kind of work, some have argued that we cannot have come from just two first parents.
[Location 2102 in the Kindle edition]
Gauger wants to take exception to the first part. Evidence that points to human origins from a collection of a few thousand individuals is not conclusive. The original pair of humans is not ruled out by modern research. The sum total of the piece is a glaring heap of wishful thinking, as would be evident to people knowledgeable of the subject and taking time to run down all Gauger's arguments. And that I will leave to others, since it is beyond the scope of my expertise to critically evaluate the opposing arguments. I will just get to Gauger's concluding statement:
So let me restate: the best explanation for the similarity among alleles is convergent evolution (or possibly original diversity), and not TSP. Finally, this analysis is strong evidence that TSP does not rule out a bottleneck of two.
To sum up, it's very simple.
- A bottleneck of two that is older than 500,000 years ago cannot be ruled out. That does not mean such a bottleneck ever existed, but rather that the possibility cannot be excluded. Future models may change that number of 500,000 years, up or down.
- This is based on an analysis of the genetic data run by Drs. Schaffner and Swamidass, themselves evolutionary biologists and not ID supporters.
- In addition, the bottleneck hypothesis stood up to a test using TSP (trans-species polymorphism). The test showed TSP was due to convergent evolution. This was a surprise to Dr. Swamidass.
- A bottleneck of two, or a first pair at our origin older than 500,000 years, is possible.
- Evolutionary biologists, including Dennis Venema, can no longer say we had to come from a population of 10,000 at any time over the last 3 million years.
Obviously, there is no rigorous science being argued here. This amounts to a special pleading for religious belief, particularly for biblical truth. Along that line, Gauger is not attempting to sell the full load. The Bible recounts the origin of the human race from two people. Gauger stops there. She lets slide the remainder of the story—that all this happened little more than 6000 years ago. Lady, if you're in for a penny, you need to be in for a pound.
It's an interesting twist we are observing. In days gone by—actually, in decades gone by—those people at the Discovery Institute sought to sell Intelligent Design as legitimate science, devoid of religious indoctrination. They seem to have thrown that notion over and have now gone full Monty pushing for the Abrahamic religions, particularly Christianity. At times the openness can be refreshing.


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Sam is basically right, he's just cranky.
No, no, he did. In the everything else section, at least. Officially, this makes him king.
Will the original game work with this? I still have this and Conquers installed. I even play it now and then. Its still very fun.
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News £2.7 million bid to save Pieter Brueghel the Younger's Procession to Calvary ends in triumphA National Heritage Memorial Fund award of more than £1 million keeps the painting at Nostell Priory, capping a three-month campaign.06 January 2011
News £5.5 million new institute for Spanish art in Bishop Auckland to "stand up against any museum in world"Curators say a new £5.5 million institute of Spanish and Hispanic Art in County Durham, planned as part of the restoration of Auckland Castle. will "stand up against any museum in the world".09 November 2015
News Ancient texts from Bodleian and Vatican Libraries available to view onlineA four-year agreement will allow treasures from the Bodleian and Vatican Libraries' collections of Greek, Hebrew and early printed biblical texts to be viewed free online.03 December 2013
Association or society County: Greater London Blue Badge Guides: First World War Walks London
News British Library joins collections from seven countries for Europeana World War I projectMore than 400,000 resources from World War I will be made available to the public online as part of an ambitious alliance to mark the centenary of the outbreak of the conflict.15 November 2011
Curator's Choice Curator's Choice: A classic 19th century trombone made by saxophone forefather Adolphe Sax in ParisWe head to Brussels to hear about a trombone from 1876 with six independent valves and seven bells, as seen by Jo Santy, of the Musical Instruments Museum.24 May 2016
Interview Curator's Choice: Ann Bukantas on Henri Matisse's rabbits at the Walker Art GalleryA double spread by Matisse in the major show of his work at Liverpool's Walker, featuring fleurs-de-lys and rabbits – a Medieval symbol of love and fertility.24 October 2011
C24 Feature Curator's Choice: The Moving Word: French Medieval Manuscripts at Cambridge UniversityProfessor Bill Burgwinkle on the legends of Arthur, Lancelot and the Round Table, strangulation and a period of language sometimes written out of literary history.22 January 2014
Interview Curator's Choice: The Pre-Raphaelites and Italy unites rare pair at Oxford's Ashmolean MuseumCurator Colin Harrison tells us about two paintings from a major 2010 show on the Pre-Raphaelites at the Ashmolean.20 September 2010
Interview Curator's Choice: The striking image linking Henri Matisse's jazz and love of art at the WalkerCollection curator Emma Baudey on Sword Swallower, a piece linking jazz and the circus on through pieces of coloured card at the Walker Art Gallery in Liverpool.24 October 2011
C24 Feature Curator's Choice: The unseen literature of the cataclysmic Liberation of Paris in 1945Charles Chadwyck-Healey's collection of the extraordinary publishing spree following the liberation of World War II is about to go on display in Cambridge.06 May 2014
C24 Feature Curators, the artist and our verdict on Anselm Kiefer at the Royal AcademyCurator Kathleen Soriano, the Royal Academy of Arts' Tim Marlow, our reviewer Nick Stockman and Anselm Kiefer himself on the moving new exhibition in London.02 October 2014
News Depression, despair, love and parties: Iris Murdoch's letters go on show at KingstonKingston University has bought a series of letters laying bare the troubled private life of 20th century writer Iris Murdoch.28 April 2010
Digital devisers take to British Library for Europeana online cultural challengeDozens of developers have descended on the British Library in a bid to work out new ways of presenting collections online.13 June 2011
Campaign or initiative: Association or society County: Surrey DropBy Godalming
News Elmgreen & Dragset's Powerless Structure and Katharina Fritsch's giant cockerel hit Fourth PlinthScandinavian duo Michael Elmgreen and Ingar Dragset will bring a child hero cast in bronze to Trafalgar Square next year, followed by a hallucinatory giant blue cockerel by German sculptor Katharina Fritsch.14 January 2011
News Emigrant's Story Is Told Online By Ulster American Folk ParkOver the coming months Ulster American Folk Park will be telling the story of an Irish emigrant's journey across the Atlantic through extracts from a diary he kept on the way.21 June 2004
Preview Erik Van Lieshout's stories from the shadows: How Can I Help You? at the Hayward GalleryThe Dutch absurdist explores marginalised communities via an abandoned shopping mall unit in his first UK solo show.10 January 2011
In Pictures French Portrait Drawings: Ten works from the British Museum's upcoming exhibitionTaken from a collection of French portrait drawings, next month's exhibition at the British Museum illustrates the power of the medium between the Renaissance and the 19th century.08 August 2016


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Clive Parkman appointed as new MD for Daikin Applied UK
As of Tuesday 3rd January 2017 Clive Parkman took on the role of Managing Director of Daikin Applied (UK) Ltd and with it the overall responsibility for the day to day running of the business.
Clive has significant experience of the UK Chiller and Air Handling Unit market, having led Airedale International and Barkell successfully over a period of growth for a number of years. His appointment will provide the company with additional insight and experience, focusing on delivering innovative project design through to delivery and further developing exceptional customer service and support.
'I believe this is a great opportunity for me to continue the positive work undertaken over the past few years and I am pleased to have joined the business at this time' says Clive. 'It is clear, there is a great team in place and hopefully I will be able to guide and assist them in delivering further improvements through product innovation and improved customer service. We will be looking at all aspects of the business and implementing positive changes that will continue Daikin Applied's growth and further establish its UK operations.
Daikin is a world leader in the HVAC space and they continue to develop products focused on improving energy efficiency and exceeding environmental targets; our job here in the UK is to continue to provide our clients with market leading Chiller, AHU and Service & Maintenance solutions, designed specifically to meet their needs. With a strong portfolio of products and services and a wealth of knowledge within the organisation, I look forward to taking Daikin Applied UK in the next stage of its growth'.


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Gear Review: Kelty Light Year XP 20 Sleeping Bag
Want a quality shoulder-season bag for a song? Get this sack. The Climashield XP insulation kept our tester cozy on chilly Icelandic nights, plus several late-fall New England outings when she camped sans tent in lows that neared 20°F. The mummy cut is thermally efficient: no excess space to heat, just enough room for squirming. The three-quarter-length zipper never snagged during cold-finger fumbling, thanks to stiffened channels that run along both sides of the zipper, plus a wide swath of ribbon along the draft tube.
And the foot vent increases comfort on warmer nights. The simple hood is deeply pocketed (read: warm) and its single, one-handed adjustment was easy to operate in the dark. We also liked the clean draft collar, which hangs freely from the top of the bag and requires no cords or Velcro. Tradeoffs? The bag is a bit on the heavy side, though it packs down to soccer ball-size and comes with a compression sack. $130; 2 lbs. 14 oz. (w's reg); 4 sizes (two men's, two women's); kelty.com


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Lirong Xia, Vincent Conitzer
Usually a voting rule or correspondence requires agents to give their preferences as linear orders. However, in some cases it is impractical for an agent to give a linear order over all the alternatives. It has been suggested to let agents submit partial orders instead. Then, given a profile of partial orders and a candidate c, two important questions arise: first, is c guaranteed to win, and second, is it still possible for c to win? These are the necessary winner and possible winner problems, respectively.
We consider the setting where the number of alternatives is unbounded and the votes are unweighted. We prove that for Copeland, maximin, Bucklin, and ranked pairs, the possible winner problem is NP-complete; also, we give a sufficient condition on scoring rules for the possible winner problem to be NP-complete (Borda satisfies this condition). We also prove that for Copeland and ranked pairs, the necessary winner problem is coNP-complete. All the hardness results hold even when the number of undetermined pairs in each vote is no more than a constant. We also present polynomial-time algorithms for the necessary winner problem for scoring rules, maximin, and Bucklin.
Subjects: 7.1 Multi-Agent Systems; 9.2 Computational Complexity
Submitted: Apr 15, 2008
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Jonavan Roux's and Bear
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- Nickolaus Moormann - Sept 15, '08
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The UC Berkeley Graduate School of Journalism will be well represented at this year's News and Documentary Emmy Awards, with six alumni and several lecturers nominated for more than a dozen awards.
Tommy Nguyen, part of UC Berkeley's Class of 2005, is up for three awards for his work as a video journalist and producer on NBC Dateline's "A Bronx Tale." Nguyen was nominated for outstanding video journalism, best report in a news magazine, and outstanding feature in a news magazine. "A Bronx Tale" relates the story of a man who proved his innocence after nearly two decades in prison for murder.
While completing his master's degree at the Journalism School, Nguyen also wrote, produced and edited Boom Town, Vietnam – a 2005 film series that won a student Emmy.
Nguyen's classmate Jonathan Richard Jones, who also graduated in 2005, is up for two awards – alongside journalism lecturer T. Christian Miller – for Firestone and the Warlord, a collaboration between ProPublica and Frontline. The story is a groundbreaking investigation into the role of the American corporation Firestone in Liberia's brutal civil war. Jones and Miller are nominated both for outstanding research and outstanding long-form investigative journalism.
Jason Spingarn-Koff, who graduated with the Class of 2001, has been nominated in the "new approaches: arts, lifestyle, culture category," for work as executive producer on Notes on Blindness, a New York Times Op-Doc film series following one man's social and emotional experience of going blind. Spingarn-Koff took home an Emmy last year.
Daffodil Altan of the Class of 2004 is also up for new approaches award, in the current news category, for her reporting work on the Center for Investigative Reporting project "The Box: Teens in Solitary Confinement in U.S. Jails, Prisons and Juvenile Halls."
Bret Sigler, a 2003 graduate, has been nominated for the outstanding editing award for his "Go or No Go: The Challenger Legacy," a New York Times report revisiting the 1986 Challenger tragedy. And Sweta Vohra of the Class of 2010 is up for outstanding coverage of breaking news in a news magazine, for her work producing "Ferguson: City Under Siege," on Al Jazeera America's weekly investigative program Fault Lines.
The list of Emmy nominees also includes journalism lecturers and former lecturers, including Josh Williams, Shan Carter, Kevin Quealy and Sharon Tiller.
"It brings a thrilling sense of pride when students and faculty receive awards for good work," said Joan Bieder, associate dean and professor at the Graduate School of Journalism.
The awards will be presented Sept. 28 in a ceremony at Lincoln Center in New York City.


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A guide to shooting like Bailey
By Alex on 28th Sep, 2012
We know great photography when we see it. Now discover some of the tricks that have helped our David Baileys capture some amazing shots.
There is no formula to taking great photography, but there are a few tips that our David Baileys truly believe helped them in their pursuit for professional photos.
Some may work for you, some may not. The most important thing to remember is that the following tips are meant only as a guide, not as a set of rules.
1. Trust your instincts
Your photographs are about you. So follow your instincts. Shoot what you find interesting and curious. There is no right or wrong. So feel free to play and experiment. Find your own way and you can't go wrong.
2. Your camera is your friend
Photo opportunities come when you least expect them. Very often a great shot is about being able to respond quickly. So keep your camera with you. If you don't have your camera by your side you won't get the shot.
With features like Smart Auto 2.0, which automatically selects the best setting for you, it feels as though every moment is an opportunity.
3. Capture stories
A photograph has the ability to convey emotion, mood, narrative, ideas and messages – all of which are important elements of storytelling. Leave the viewer of your photograph wondering what's just about to happen or what's just happened. And don't forget the new Remote Viewfinder App. This allows you to put yourself in the picture and still maintain creative control.
4. Be patient
In photography, it's true that good things come to those who wait. Whether you're waiting for the sun to rise or reappear from behind a cloud, your child to run past on their sports day or a geyser to blow, five minutes can make the difference between an okay picture and an amazing one.
5. Never say cheese
If you are taking a portrait or group shot, shoot before and after the subjects think you have taken the shot. You'll often get a more natural image when they think you're fiddling with your settings.
6. It's all about light
Photography is all about light. So play with it. Look at how light and shade create forms in your images. A commonly held belief is that shooting into the sun is a bad idea, but try experimenting with lens flares, shadows and silhouettes. You will be surprised at some of the amazing things you capture. And with features like the enhanced ISOS, which lets you take photos with minimal light, you'll be producing wonderful images that you thought weren't possible.
7. Shoot movement
Movement can bring your pictures to life. So play with speed. You might want to try panning your camera in time with a moving subject. The subject ends up relatively sharp and the background blurred. This gives focus to your subject and also a feeling of movement.
8. And lastly, but most importantly... Have fun
With features like built-in Wi-Fi for sharing with friends and family, this shouldn't be too hard.
Get to know the Samsung NX cameras with the help of our David Baileys. When looking for that great shot, their handy tips could make all the difference.
Inspired to get creative?
If reading this has inspired you to get creative, take a look at the Samsung NX Range of smart cameras and find one that is perfect for you. It could be the start of something great.


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My heart tells me there is only one authentically Jewish response to the immigration debate raging in our country. The story of the immigrant, the stranger, the "other," is our own story. As Jews, we can do nothing less than champion the needs of the immigrants in our midst with the full force of our spiritual and political power.
Do not oppress the stranger; you know the soul of the stranger, for you were slaves in the land of Egypt. (Exodus 23:9)
You shall not wrong or oppress a stranger, for you were strangers in the land of Egypt. You shall not ill-treat any widow or orphan. If you do mistreat them, I will heed their outcry as soon as they cry out to Me . . . . (Exodus 22:21-4)
My father was a fugitive Aramean . . . (Deut. 26:5)
When a stranger resides with you in your land, you shall not wrong him. The stranger who resides with you shall be to you as one of your citizens; you shall love her as yourself, for you were strangers in the land of Egypt: I the Lord am your God. (Leviticus, 19:33-34)
More often than any other mitzvah in the Torah, we are commanded to champion the needs of the vulnerable in society, including the "stranger," the immigrant, and the foreigner, for we know deep in our collective being what it is to be the persecuted minority, the outsider subject to prejudice and oppression.
Our story as a people began when our homeland was beset by famine and economic hardship. We migrated to the land of Egypt, where skillful governance had created more prosperity. Like the desperate immigrants of today, we were willing to suffer the loss of home and dignity, to risk everything by crossing into a foreign land, for our lives and the lives of our children depended on it.
The Torah commands us with resounding power not to turn our backs on these formative experiences. Rather, we are called to live out our empathy with the immigrants and strangers of the times and places in which we live.
Of course, our experience as a nation of immigrants did not end with our exodus from Egypt, but came to characterize much of our history. History relentlessly reinforced the lesson that God had commanded: We know the soul of the oppressed, the vulnerable, the "other." This call to champion the needs of the victimized is central to who we are as Jews.
More broadly, a Jewish response to immigration must take account of Jewish sources on the central verse of the Torah, "Ve'ahavta lerei'acha kamocha," "Love your neighbor as yourself." (Leviticus 19:18) Our exegetical tradition contains different views on the scope of this commandment. According to one view, the verse applies only to one's fellow Jews. But the strand of the tradition that resonates most deeply in today's global reality declares with persuasive clarity that we are to love all people as our neighbors and fellow travelers on this earth.
Similarly, some commentators see the Torah's command, "Do not hate your brother in your heart," (Leviticus 19:17) as applying only to the Jewish family. In today's world, many of us understand that the sacred call is to embrace every member of the human family as our own kin. Thus, the Torah expressly forbids the kind of hatred, prejudice, and racism that too often enliven the punitive voices in the immigration debate.
Surely, good people can and will disagree about how to translate the Torah's broad ethical principles into wise contemporary public policy. Yet for me, the core truth of Jewish teaching is clear, as articulated in this remarkable midrash:
God gathered the dust [of the first human] from the four corners of the world — red, black, white, and green. Red is for the blood; black is for the innards; and green is for the body. Why from the four corners of the earth? So that if one comes from the East to the West as he nears the end of his life, it will not be said to him, "This land is not the dust of your body; it's of mine. Go back to where you were created." Rather, every place that a person walks, from there he was created and from there he will return. (Yalkut Shimoni, Genesis 1:13)
Reprinted with permission from Sh'ma: A Journal of Jewish Responsibility (shma.com), Vol. 52, No. 672.


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Behind the Decks at Vinyl Club
We got behind the decks with Carlos from Vinyl Club to find out all about this new event springing up in the east end.
The concept is to invite new and undiscovered talent to showcase their music, exchange records, guide them on technical skills and invite well known DJ's to come and show others how they perform. There will also be talks and presentations from different areas in the music industry, and guidance on many subjects, from how to put you music out there, starting a label, producing tips, marketing, branding yourself as an artist, and other subjects in the music industry.
Check out our interview with Carlos to hear more about Vinyl Club.
To get involved email your 30 minute house mix to firstname.lastname@example.com
WHEN: The next event is on Thursday January 30th at Ground 281


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Can you guess which one is me?
Excuses are like long term personal contracts that freeze a person's ability to make change, take action, move forward. One of the worst excuses I often hear people expound upon is the fact that blogging and social media networking is just too time consuming, not effective enough, or over their heads technologically. Bull_hit! It is all about your willingness to learn, expand your knowledge base, dedicate yourself to the task, and remain steadfast on course through dedication.
Back in 1978, there was very little technology that allowed a person or business to network themselves and build their brand. How did I arrive at this subject?
My 30 year high school reunion, Terra Linda High School in San Rafael, CA, is being held tonight and it sparks many memories. One of the biggest memories is how our world used to be and how technology has changed what we can do, where we can go, and who we can ultimately become due to the advances.
In order to appreciate the Web 2.0 world of Social Networking tools, blogging, and the global conversation that is inspiring a seachange in the media and information industry, lets take a look back at where we used to reside: 1978.
You have NO excuse not to network, connect, and utilize the tools of blogging and Web 2.0 to your advantage. Here is what you would have faced 30 years ago:
Technology in 1978: Or what I used to do, what I could not do, and what I never knew I wanted to do
1. Remote Control: I was my father's remote as I sat by the TV while he pointed and "clicked"
2. Cable TV: We had 4 channels 2-4-5-7; ESPN did not exist, cable TV did not exist
3. VCR-Video: VCR's were invented but not in the market in my area, Video stores did not exist
4. No MTV: Music videos did not exist
5. Microwave Ovens: no microwaves, no Hotpockets!
6. "Partyline": no not some 900 number. My grandparents phone service was a party line where 6 families shared the same phone line!
7. No Internet: ?????????????
8. No Personal Computers
9. No Video games: Pong was just around the corner
10. No Cellphones
11. No Answering machines: if you missed the call you were left wondering
12. No Voicemail: same thing but now you could screen calls without screwing up!
13. No Social Media Networking: Facebook, twitter
14. No Niche Media Networking: Linkedin, Plaxo
15. No PDA
16. No Video Cameras: none that were small and affordable only the mass media behemoths
17. Microcomponents: Sterio components and speakers were HUGE
18. CB Radios: They were a national phenom and since technology have gone back to their intended use
19. Ham Radio: Same thing Hamm Operators are a dying breed with the internet, skype, and other technologies
20. Networking: Back in 1978 it was through your family, Chamber of Commerce, Barbershop, or the local rag newspaper
21. Sadly No Active Rain: Are there words to express my gratitude?
Where can you find me if not in the picture above:
1. Active Rain profile
2. Innerarchitect.com/about
3. Linkedin.com profile
4. Facebook.com profile
5. Collegeplanningspecialist.wordpress.com author
6. Plaxo.com me
7. twitter.com deansguide
If you can't get find me to network with me–you ain't tryin!


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Our History
In the spring of 1983, a small group of men supported by their wives talked about starting a new Presbyterian church in the Seven Oaks/Irmo area that should have two goals: to stand for biblical truth and to be mission-minded.
On a Sunday evening in June of 1983, a group of people gathered at Leaphart Elementary School on Piney Grove Road for the purpose of worshiping God. Hymnbooks were borrowed from First Presbyterian Church of Columbia and buckets from Kentucky Fried Chicken were used for the offering baskets. The next Sunday, it was announced that there would be a regular worship service and Sunday school held at that location.
In the fall of 1983, the church authorized the purchase of 6.75 acres on St. Andrews Road across the street from what is now called CrossRoads Intermediate School to be its official 'home'.
Since 1983, Saint Andrews Presbyterian Church has been a part of the Presbyterian Church in America (PCA).
During Christmas of 1984, the first worship service was held. In 1988, a three story building was completed to house our Family Center and adult and youth education classrooms. In 2002, SAPC "had a baby"—a church plant in Chapin to reach out with the gospel to those in that community. Dr. Dale Welden was called as the third Senior Pastor of SAPC in August of 2006. The Great Hall, Youth Area, Worship & Arts Suite, and extensive renovations to the Sanctuary, Children's Ministry area and staff offices were completed in August of 2012.
To this day, Saint Andrews Presbyterian Church continues with the goals that the first members put forth: to stand for biblical truth and to be mission-minded.


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MWC 15 Special
Silent Circle and Geeksphone today announced a new Switzerland-based joint venture and its inaugural product - the Blackphone - which is said to be the world's first smartphone placing privacy and control directly in the hands of its users. While the press release stays pretty mum about technical details and features, it's said that the Blackphone is powered by a security-oriented Android build named PrivatOS. The target of Blackphone is a carrier- and vendor-independent smartphone giving individuals and organizations the ability to make and receive secure phone calls, exchange secure texts, transfer and store files and video chat without compromising user privacy on the device.
The Blackphone is the culmination of several careers' including well known Phil Zimmermann, creator of PGP; Javier Agüera and Rodrigo Silva-Ramos co-founders of Geeksphone; Jon Callas, co-founder of PGP Inc. and CTO of Silent Circle and Geeksphone; and Mike Janke, CEO of Silent Circle and former US Navy SEAL.
The Blackphone will be available for pre-order beginning February 24, 2014, at Mobile World Congress but before anyone is going to order one, Silent Circle and Geeksphone might want to put the full specs on the table first. So far, Blackphone's web site is only showing the video above which doesn't tell us too much what potential customers can expect.
Anyway, whatever the Blackphone is or will be, the current discussions in Europe about the NSA activities here might help Blackphone to find its market and who knows, maybe it's even Chancellor Merkel's next business mobile phone?
Cheers ~ Arne
Article Source
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Calculate! Health (12 months) Subscription
This is a 12 month subscription (365 days) to the Calculate! Health products. Anytime there is an update or upgrade you will have access to it as long as you are an active member.
Please provide us with the information below to sign up and pay for the subscription. Upon payment, an email will be sent to the one specified, and your account will need to be activated before you can login and access your downloads.
Thank you.


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White Mirrored Dresser And Bedroom Furniture
When choosing the furniture for the bedroom with white mirrored dresser. You should definitely explore the many mirrored furniture parts available. The furniture with front mirror visually expands the appearance of each bed. Mirror that reflects the light of the sun that illuminates the room. Including some waxing your décor, you can create a relaxing atmosphere in a room with a mirror. Flickering candle light reflecting in the mirror is the latest in romantic design.
The cupboard with the mirror at the front door is an awesome addition to any room. This will not only add beauty to the room. It will also provide a series of additional storage space for clothes or sheets. The style that touches the table with the mirror is virtually unlimited. Its range of antique dresser options ultra modern white espresso color sideboards. Vanity is a great addition to the room. Their styles vary just like the mirror style that accompanies them. Vanity Mirror is a very elegant for a guest room or a suite. The reflective quality of the whole table creates an imposing focal point for your bedroom.
24 Photos Gallery of: White Mirrored Dresser And Bedroom Furniture
In addition to the usual combination of cabinets and mirrors, cupboards, sideboards, or there is an accent mirror table also can be included in the design of your bedroom. Reflected writing desk will add elegance to your bedroom décor. The mirrored side table or accent table can be placed next to the chair in your bedroom to create a reading area or relaxation. A bedside table or night stand with the mirror surface adds to the beauty of modern sparkle style rooms. The combination of chrome furniture with mirror is add to give the bedroom a very open and spacious quality. The length of mirror floor dressing is a beautiful and useful addition to your bedroom. You can find this mirror will look in a style that suits any decorating style.


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1. Facilities
Included in the price:
• Free delivery and collection in the whole island.
• All taxes (24% VAT and 0,5% local tax) for online reservations.
• Child seat free of charge, given that there is reservation and availability.
• For motorbikes and ATV's oil for the fuel, helmets and top case or binding rubbers.
• Unlimited kilometres
• Road map, useful information
• Simple insurance (for material damages and bodily injuries) of third parties. In case of accident , the Lessee is charged with the damages of the leased vehicle and the cost of the days that it will take for the vehicle to be repaired.
2. Driver
• Driver's age The minimum age limit is 23 years for category S , 23 years for all category vehicles, except for categories D,E,F for which it is 25 years.
• Driver's license Greek, European (for EU countries) or International (for countries not belonging to the EU), issued at least before 3 years for vehicle categories: D,E,F and for the rest categories a year ago at least.
3. Fuel
The vehicle shall be returned with the fuel level same as upon delivery. Otherwise, the Lessee shall be charged with the cost of missing fuel. There is no refund in the event of return of a vehicle with fuel level higher than its initial one.
4. Minimum Lease Term
One (1) day (24-hour day). Every additional hour is charged with 1/5 of the daily charge. Vehicle possession exceeding 3 hours shall be charged an additional day.
5. Extension or Shortening of Lease Term
The Lessee has the right to extend the lease term by notifying the Lessor and receiving his written consent. In the event of return of the vehicle prior to the expiry of the agreed lease term, there is no refund.
6. Fines / Penalties
All fines and administrative penalties incurred during the lease term are born by the Lessee.
7. Insurance
In the rental price ,simple insurance(for material damages and bodily injuries) of third parties is included . In case of accident the Lessee will be charged with the damages of the leased vehicle and the cost of the days that it will take for the vehicle to be repaired.
8. Coverage for Non-insured Amounts
The Lessee may minimize his responsibility for loss or damage caused to the leased vehicle through the purchase of Partial Collision Damage Waiver (CDW) whereby he legally participates in damage repair of the vehicle:
A. For vehicle categories A,B,C,E, the Lessee can minimize his responsibility for his legal share in any damage of the vehicle to 750 € by paying the amount of 12 € per rental day.
B. For vehicle categories D, F to 900 € by paying the amount of 16 € per rental day.
C. For vehicle category S to 300 € by paying the amount of 6 € per rental day.
D. For vehicle category G1 to 400 € by paying the amount of 7 € per rental day.
E. For vehicle categories M1, M2 to 400 € by paying the amount of 8 € per rental day.
F. For vehicle categories M3, M4, G2, G3 to 400 € by paying the amount of 10 € per rental day.
If the Lessee wishes to purchase Full Collision Damage Waiver (FDW), he is subject to an extra daily charge of 7 € for vehicle categories A,B,C,E and a charge of 9 € for vehicle categories D, F.
CDW and FDW insurance does not provide any coverage for damages provoked during the transportation of the vehicle by ship, partial or total theft, loss of its parts / accessories or personal property on or inside the vehicle, damages caused to it due to negligence, intent, natural disaster, terrorist act, breach of terms and conditions of this lease Agreement or violation of the provisions of the Greek Driving Code (KOK), damages caused to the vehicle keys, tires, mirrors, lower / upper part of cabin, inside the vehicle, loss of vehicle documents or registration plates.
9. Cancelation policy
In case of cancelation, up to 7 days before the delivery of the vehicle, the Lessee is charged only with 10 euro cancelation fine and from 7 up to 2 days with the 50 % of the deposit. In case of no show the arranged day and time for the delivery of the vehicle, without prior written or phone notice, the reservation will be cancelled after an hour and the full amount of the deposit will be held.
10. Reservations - Payment
Reservations are made with deposit into a bank account or with use of credit cards Visa, Maestro, American Express, Diners Club. The balance is possible also with cash.
11. Vehicle Transportation
Transporting the vehicle by rail, ship or another mode of transportation is prohibited without the prior written consent of the Lessor.
12. Price revaluation
The terms and prices of the pricelist may be modified without warning after relevant permission by the EOT.


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Who knew that a Summer Shrimp & Corn Salad, sans any red meat, could impress us "boneheaded meat lovers"?
Well, I should have!
My goddaughter is a good writer, knows her food and is très amusing in how she expresses herself in her recipes.
I recommended WordPress to her but she went with Google's Blogger instead, so I was amused to read a recent recipe start out with "Dear God, Blogger was giving me such shit last night. I meant to write this yesterday evening whilst I was leisurely enjoying a glass of good-for-me red wine (to celebrate some good news I received about my health, lulz) but no, Google was not having it. Damn you Google and your salad sabotaging ways!"
P.S. It must be the optional extra bacon which makes us bonehead meat lovers interested. Our intrepid foodie writes "I don't give a flying fart in space if you want to use 8 slices of bacon instead of 6". Right you are, I'll definitely have 8 … or more. Good read, even if you don't cook. Enjoy!
Photo credit: SouthAfricanBokkie


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The following websites provide information, help, and guidance in resisting pornography.
NOTE: These sites are not affiliated with the Family Life/Respect Life Office of the Archdiocese of New York. We provide this information solely for your information. We are not responsible for, nor do we endorse, their policies, the views they express, the products and services they offer, or the content of their materials or websites.
Catholic Websites
Christian Websites
Non-Religious-Affiliated Websites
Internet filters, Accountability Software, and Media Safety
Men's Groups
- The King's Men: www.thekingsmen.org
- Promise Keepers: www.promisekeepers.org
Self-Help Groups
- Sexaholics Anonymous: www.sa.org
- S-Anon International: www.sanon.org
Bishops' Statements
- Bishops Approve Formal Statement, 'Create In Me A Clean Heart: A Pastoral Response to Pornography' (Nov. 17, 2015)
- Blessed Are the Pure In Heart. A Pastoral Letter on the Dignity of the Human Person and the Dangers of Pornography by Bishop Finn, Diocese of Kansas
- Bought with a Price by Bishop Loverde, Diocese of Arlington, VA
Recommended Articles
- The Weight of Smut by Mary Eberstadt
- Thanks A Lot, Oprah by Ed Mechmann, Director of Public Policy and the Safe Environment Office, Archdiocese of New York
- Pornography: What's the Problem by Mark J. Houck
- The Effects of Pornography on Individuals, Marriage, Family and Community by Patrick F. Fagan, Ph.D.
- Safeguarding the Heart of Marriage by Theresa Notare


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Hey 3.5 readers.
Came across this interesting PR Newswire press release.
99 Designs has been providing authors with the ability to hold book cover design contests for a long time. Now they're branching out into book layout, typesetting, interior book design, basically.
Could be a boon for self-publishers. I know I tried Adobe one time, gave up on trying to figure it out, and came to the conclusion that if the inside of my book was ever going to look good I was going to have to hire someone to do it.
What say you, 3.5 readers?


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Some elements of a great video are obvious. These are things like a focused and well told story, appealing visual elements, well laid out design, etc. That said, the most underrated – yet crucial element – is the quality of the script and voiceover.
What is the most important part of a baseball pitcher's pitch? The follow through. That's the same thing with video. It will be ruined if it doesn't make sense or sound great. We want to help you with two aspects of this activity:
Script Writing Editing
We will help you write and edit your script until it's ready for production. The script will be the foundation for the entire video, so it needs to be well thought out – and you shouldn't go it alone.
Voiceover Artist Recording And Editing
Yep, that's right. We will professionally record one of our voiceover artists with top-of-the-line equipment. We'll record each sentence four or five times, then edit the whole thing back using the most animated, entertaining, and well articulated sections.
To order a voiceover, the first step is to start a casual email conversation with someone from our team. So fill out the contact form below and we'll get back to you ASAP.


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Dragoncloud888 on Jul 18, 2014 wrote:I have one Grandmaster and that's pretty much all. My other characters are level 14 or less. So I'm only level 50 and I've been playing this game for almost a year. Is that weird? People on the forums say, "Oh, yeah, I completed that world in seven hours." How do you complete a whole world in seven hours Let me just say I do all the side-quests and although I play almost every day, I really take my time in doing stuff. Should I try to speed up the process of leveling up and be awesome really quick or just sit back and enjoy the game? Myrna Dragoncloud, Grandmaster
RavenLady777 on Jul 18, 2014 wrote:You don't complete any world in 7 hours except possible Wizard City. You are doing things exactly right... enjoying the game (not speeding through to 'beat' someone's level or something as ridiculous) and doing your side quests. You will have a much easier time in higher worlds and levels by doing all this. Ignore the jealous and liars... just have fun! Isn't that the point of a game?
DanTheTerrible2 on Jul 19, 2014 wrote:This is a game. The point of a game is to have fun. If you are having fun playing then by definition you are doing it right. If you feel pressured to grind out levels faster than the next guy, you are in danger of turning W101 into monotonous job, not fun. That would be playing it wrong.
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Check em out
Sitka bivy - I liked it. It was slim and light weight. No real issues except a lack of space for other stuff
AGC cub - so far I LOVE this thing. By far the best of the 3. Lots of room and great fit.
I prefer simplicity. So I've gone back to the basics and love it! Crooked horn strap with the bino shield for protection. I walk miles with my 10x42 Zeiss Victory HT with no issues.
1. Sitka 2. Outdoor Vision 3. AGC KISS Max
I've used most of them on the market, these are my favorites.
I am looking at some of the others mentioned here
I have an Outdoor Vision on the way after lots of research. Really liked the new Sitka bivy too.
My favorite in the way they work and comfort is the cheap Allen bino shield. I swear I like them. Would never have tried the other three brands if this one wasn't so noisy when cold. They work well.
My advice is if you aren't going for a magnetic closure, just get the alps x bino pack. It works great considering it is loop closed and open toward the user. Both negatives for me.
I'm with Pav on this one. Kuiu with separate top straps would be just about close to perfect. As is- it's frustratingly serviceable, but still better than most of the rest.
I will be in Africa for the next couple of weeks but can send photos when I get back.
Please PM if you are interested.
FULL DISCLOSURE: At the moment, we are extremely busy, building as fast as we can. Shipment could be 2-3 weeks (depends on size & color - some could ship same day). Also, please feel free to let me know if you have any questions. Thanks, Geoff
I wonder how much the back piece breathes.
ohiohunter's Link
geoffp's Link
The Outdoor Vision seems very similar to the Marsupial Gear harness that I own. Both are magnetic and open to the front. The OV fully contains the binos. The Marsupial contains them about 3/4, which allows the binos to be pulled out and put back a little easier/quieter but may allow dust/moisture to get in. They are nearly identical in weight. Their rangefinder pouches also seem to be nearly identical.
On my range finder I had used the pouch that came with my Nikon. It was fine but my god is the OV holster and tether slick. Effortless to use fast and quietly without looking both in and out, really love that thing.
So far, a good company to deal with.
The harness is really well-laid out, generally speaking the best I have tested - similar to the AGC but in a more streamlined package. Quality hardware all around. The top and bottom straps are connected to the body so it will no droop when the binoculars are out of the pocket a la the Kuiu bino harness - my biggest complaint and one shared by others. The unit ships with straps to connect the binoculars to the harness. The lid opens forwards (like Kuiu/opposite of AGC) but I can't envision it interfering with the bowstring. It is held in place - both open or closed - by magnets. The grab handle on the lid is large and easy to locate - big enough for gloved hands. The outward facing material (front/sides) is similar of that of the Kuiu, so pretty quiet. It has a zippered pocket on the front w/ included minimalist first aid kit where you could carry your license, tag, lighter. etc. There is a small zippered pouch on the bottom which contains a cleverly laid out rain cover which is attached (though removable) with room for a bit more.
For those who ride ATV's or have dust issues, coverage of the binoculars is almost complete with only tiny gaps on either side (the lenses should still be fully covered top and bottom). Coverage is not as good as the Badlands and perhaps AGC, but much better than Kuiu and some others.
Unfortunately, due to my personal physiology (an issue I have not read of others having) - I had the same issue with this product as I did with the AGC. My eyes are rather close together so when properly adjusted my binoculars are "tall and narrow", and the depth of the pocket - call it the front to rear dimension of ~ 1.5" - was not ample enough for me to be able to easily replace my binocs with one hand when done using them. As a comparison, my Kuiu harness is about 2.5" deep and I can just drop my binoculars right in with one hand and then close the lid.
I'm not a fan of the magnet closure either given the potential for unintended noise, but this unit is much quieter than Badlands as an example.
In my opinion, this is the best designed bino harness I have used (have not tried the Marsupial Gear unit, which looks very similar - appears to have a sleeker lid but poorer dust protection), but the dimensions unfortunately do not work for me. Unless you have a need for carrying a bunch of odd's and end's, I personally would choose the OV over the AGC based on its more streamlined and thoughtful design.
I didn't like how they both opened to the back and while the AGC was one hand operable just didn't like how bulky it felt(I had to get their largest model because of the binoculars I have). So I decided I would try my hand at frankensteining my KUIU harness to fix some of the problems. Especially the one handed operation. I think it turned out pretty good. Just have to do some more testing but so far it seems to be working well.


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Sweeney Todd: The Demon Barber of Fleet Street.
Evil Judge Turpin lusts for the beautiful wife of a London barber and transports him to Australia for a crime he did not commit. Returning after 15 years and calling himself Sweeney Todd, the now-mad man vows revenge, applying his razor to unlucky customers and shuttling the bodies down to Mrs. Lovett, who uses them in her meat-pie shop. Though many fall to his blade, he will not be satisfied until he slits Turpin's throat.
Please park in the Rushworth Road car park and arrive at least 5 minutes before the show starts.


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Thank you for your interest in becoming a VIP with APRC. We have varied and exciting volunteer opportunities to choose from, including working in parks and trails, the North Mountain Park Nature Center, Senior Center, special events, seasonal options and student projects. There is a volunteer opportunity for everyone! To learn more about the many volunteer options, click here.
Please complete the online application, or you can download the application (PDF format) and deliver it to the APRC Rec Division at The Grove, 1195 E Main St, Ashland OR, 97520.
You can complete the Adult waiver (online) or download the PDF version, Adult waiver.
For volunteers under 18 years old, the parent/guardian must complete a Youth waiver(online) or download the PDF version, Youth waiver.
Learn more about us...
Volunteers make amazing things happen! Share your time, brawn and talents with the APRC. Volunteer opportunities exist out-and-about in Ashland Parks, at organized events or on-going experiences at North Mountain Park Nature Center or the Ashland Senior Center Program.
Visit the APRC home page or contact our Volunteer & Event Coordinator, Sulaiman Shelton, at 541.552.2264 or email for more information. VIP - Volunteer in Parks, "It's the Natural Thing to Do!"