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EDTA Therapy for Vascular Disease
Chelation Natural Miracle For Protecting Your Heart
Chelation therapy has been conclusively shown to be up to 82 Percent Effective at dissolving the plaque that blocks arteries! In the ebook Chelation Natural Miracle For Protecting Your Heart you'll discover: The frustrating reason many doctors are ignoring Edta chelationor even openly rejecting it. The deadly heart surgeries even the American Heart Association admits are unnecessary. The hidden signs and symptoms of heart attacks and strokes? Are you in danger right now?. The average number of years stripped away by heart and vessel disease. Can you get them back?. The newest set of risk factors for heart disease (they'll likely surprise you!). Shady government practices that protect Big Pharma and keep Edta chelation out of the public eye. How the Roman Empire could have been savedif only they'd known about Edta chelation. Why Edta chelation is guaranteed to be safeeven in extremely high doses. (It puts aspirin to shame!). The shocking truth about plaque in young childrenand how to keep your little ones safer. Why dentists, artists and welders need Edta chelationand whether your workplace is dangerous too. The differences between IV and oral chelationand which kind of Edta is right for you. Other forms of chelationand how these little-known treatments can dramatically boost your health.
Chelation Natural Miracle For Protecting Your Heart Summary
Contents: Ebook
Author: Michael Cutler, M.D.
Price: $19.95
My Chelation Natural Miracle For Protecting Your Heart Review
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Iron Chelation Therapy
Iron chelation therapy inhibits erythrocytic Plasmodium parasites in vitro and in vivo (Mabeza et al. 1999). Ultrastructural studies show a stage specific effect on a trophozoite-to-schizont stage transition with an enlarged nucleus rather than an enlarged digestive vacuole as seen with the quinolines (Atkinson et al. 1991). Iron chelation also inhibits mouse malaria development in hepatocytes at appropriate concentrations (Loyevsky et al. 1999b). The mechanism of action with diverse groups of iron chelators can be grouped to either withholding of iron or by formation of a toxic complex with iron (Mabeza et al. 1999). Iron withholding has a direct effect on the ribonucleotide reductase necessary for DNA synthesis and or 6-aminolevulinate synthase for heme synthesis. Because of minimal effects on host cells and concurrent development of iron chelators as adjunctive cancer chemotherapy, several trials of iron chelators have been performed for both severe malaria and uncompli cated...
Endocannabinoid Uptake Studies In Vitro Assay of Endocannabinoid Uptake
COS cells (107) grown to confluence in flasks in DMEM (Life Technologies, Gaithersburg, MD) containing 10 FCS (Life Technologies) were split 1 2, harvested the next day using trypsin EDTA, centrifuged (200g) for 10 min at 4 C, washed with sterile HEBS (20 mM HEPES, 137 mM NaCl, 5 mM KCl, 0.7 mM Na2HPO4, and 6 mM dextrose), recentrifuged, and resuspended at 107 cells mL in 4 C HEBS. Then, 0.9 mL of suspended cells was transfectedby electroporation at 300 V and 1100 F in 400-mm Gene Pulser cuvettes (Bio-Rad) containing 20 g of plasmid DNA and 500 g of fish sperm DNA (Boehringer-Mannheim, Mannheim, Germany) using a geneZAPPER 450 2500 (IBI, New Haven, CT).
General Information
The use of calcitetracemate in the treatment of lead poisoning has been described (1). Between 1993 and 2000, 45 adult patients consulted the Poison Centre of Marseilles, France after lead exposure (9 women, 36 men, average age 44, range 22-76 years). In 22 patients, a calcitetracemate provocation test was negative. Six patients with a positive test refused to be treated the other 16 were treated with a total of 58 courses of calcitetracemate by infusion 500 mg bd for 5 days. The mean blood lead concentration in these 16 patients was 566, range 320-943 ng ml the mean urinary lead excretion was 3011, range 789-7229 mg day. The mean amount of lead eliminated in the urine during chelation therapy was 30 912 mg. In 12 patients in whom lead exposure ended after the diagnosis of lead poisoning, chelation therapy reduced the blood lead concentration by 69 . In four patients in whom exposure continued during treatment, the blood lead concentration fell by only 7 . In the 16 treated patients,...
Susceptibility Factors Age
Overload has been established and is associated with a significant reduction in mean body length (151,152). Impairment of growth is associated with a rickets-like syndrome and joint stiffness. Metabolic studies have shown reduced hair and leukocyte zinc concentrations and leukocyte alkaline phosphatase activity. Retardation of growth may be related to chelation of trace elements (for example zinc), to a direct toxic effect of unchelated deferoxamine by inhibiting critical iron-dependent enzymes, or to both. It is advised that in thalassemia major, treatment with deferoxamine be started only after iron accumulation is established, that is at around 3 years of age, after 20-30 blood transfusions, when ferritin concentrations are in the range 800-1000 ng ml. Deferoxamine doses should be established on the basis of studies of iron balance and dose-response curves, and longitudinal growth monitoring is warranted.
Other features of the patient
A possible relation has been suggested between toxicity and the ratio of metabolite B of deferoxamine to un-metabolized deferoxamine (SEDA-18, 250) and there is a relation between regular deferoxamine treatment in respect to the degree of iron overload, as defined by the therapeutic index, that is the daily dose of deferox-amine in mg kg day divided by the serum ferritin concentration in ng ml (SED-13, 621), and the ratio of metabolite B to total deferoxamine (deferoxamine plus ferrioxamine) in the plasma or urine (153). This is consistent with the hypothesis that metabolite B of deferox-amine, which is a product of the intercellular metabolism of iron-free but not iron-bound deferoxamine, inversely reflects the availability of iron in the plasma compartment. In patients who receive a high amount of chelation (measured as mean daily dose of deferoxamine in mg kg) in relation to iron stores (as reflected by serum ferritin in ng ml), the proportion of iron-free deferoxamine that is...
Calcineurin inhibitors
Oral absorption of Sandimmune is low (5-30 ) and highly variable, ranging from 4 to 89 in renal and liver transplant patients (33,34). Absorption of the microemulsion formulation is more consistent, averaging approximately 40 (35). Peak blood concentrations typically occur between 1-3 and 2-6 h following oral administration of Neoral and Sandimmune, respectively (33,36,37). Absorption can be delayed for several hours in a subgroup of patients. Because CsA is lipophilic, it crosses most biologic membranes and has a wide tissue distribution (38). CsA is highly bound to plasma proteins ( 90 to lipoproteins), with the majority of CsA localizing in erythrocytes. The distribution of CsA between plasma and erythrocytes is temperature-dependent and varies with changes in hematocrit (39). Because of the potential for artifactural redistribution of CsA during specimen processing because of ambient temperature fluctuations, ethylenediaminetetraacetic acid (EDTA)-anticoagulated whole blood should...
Preanalytic Variables
Plasma or serum can be used to measure MPA and free MPA blood concentrations (187). However, plasma from EDTA-anticoagulated whole blood is the recommended specimen of choice because the same sample can be used to measure whole blood CsA, tacrolimus, and sirolimus (196). MPA and MPAG are stable in whole blood and plasma samples at room temperature for at least 4h (197). Plasma samples are stable at 4 C for 4 days and at least 11 months when stored at 20 C (196). Free MPA is stable for at least 6 months when stored at 20 C (198). Thawing and re-freezing of plasma samples can be performed up to four times without significant loss of MPA (199). When monitoring MPA during intravenous infusion of mycophenolate mofetil, whole blood samples should be immediately placed in ice and the plasma separated within 30min (200,201). This is because mycophenolate mofetil is very unstable and rapidly undergoes temperature-dependent degradation to MPA in whole blood samples placed at room temperature...
Modulation of the Release of Endocannabinoids by Other Neurotransmitters
The essential finding that postsynaptic increases in intracellular Ca2+ can induce endocannabinoid release has also led many investigators to an important corollary hypothesis that activation of postsynaptic receptors known to be coupled to the mobilization of intracellular Ca2+ should also promote endocannabinoid release. At both GABAergic and glutamatergic synapses in the CNS, a number of G-protein-coupled receptor systems are known to be linked to Ca2+ mobilization, including metabotropic glutamate receptors (mGluRs Anwyl, 1999 De Blasi et al., 2001) and muscarinic cholinergic receptors (Kerlavage et al., 1987). Thus, several recent studies have investigated whether activation of these receptor systems can also facilitate endocannabinoid release. In hippocampal slices, Varma et al. (2001) showed that activation of group I mGluRs (mGluRl and or mGluR5) reduced GABA release onto CA1 pyramidal cells and that this effect was blocked by a CBj receptor antagonist (Varma et al., 2001)....
LTD at Glutamatergic Synapses in the Dorsal Striatum
The basal ganglia contain some of the highest densities of CBj receptors in the CNS (Herkenham et al., 1991 Herkenham, 1992). As was the case for other brain regions, pharmacological and electrophysiological techniques confirmed the presynaptic inhibitory effects of CBj receptors at both glutamatergic and GABAergic terminals within various basal ganglia nuclei (see Table 9.1). However, as was the case in the hippocampus and cerebellum, the fundamental link between the presence of these functional CB1 receptors and their endogenous ligands remained to be established. Anandamide release in the dorsolateral striatum, and its enhancement by dopamine D2 receptor agonists, was first demonstrated using microdialysis techniques (Giuffrida et al., 1999). Such an approach, although well-suited to addressing global or widespread activation of endocannabinoid systems, cannot assess endocannabinoid release and activity at the synaptic level. Thus, whole-cell and extracellular recording techniques...
Preparation of Cell Membrane Homogenates
The membrane homogenate preparation procedure isolates cell membranes and membrane-associated macromolecules and assures their homogeneity for assaying small fractions of the preparation in each of many test tubes. It removes the majority of soluble macromolecules, small molecules (including endogenous receptor ligands), and minerals via multiple centrifugation steps each followed by resuspension in fresh buffer containing the divalent ion chelator ethylenediamine tetraacetic acid (EDTA). Some prefer a P2 preparation, which involves discarding an initial pellet generated by a low-speed centrifugation step, but this appears to be unnecessary for these assays.
Treatment Of Toxic Element Poisoning
Removal of the poisoned individual from the environmental source (or vice versa) responsible for the toxic metal contamination and supportive care are generally all that is required for decontamination. In some cases, however, chelation therapy using organic compounds to bind and remove metals from the body may be warranted. Because chelation therapy may pose life-threatening side effects, due to the simultaneous chelation of essential elements such as calcium, care must be taken to manage the administration of chelation therapy (53-56). In any case, monitoring the elimination of toxic element exposure and confirmation of effective decontamination are useful when the appropriate laboratory specimen is utilized. For lead and iron, blood is a good specimen for monitoring decontamination, whereas urine is preferred for monitoring decontamination of mercury and most other toxic elements. Chelation therapy to treat children with blood lead concentrations of 20-44 g dL showed no benefit...
Preparation of Protein Extracts
Sonication buffer for quick and easy protocol (100 mL) 2 mL of 1 M N-(2-hydroxyethyl) piperazine-N'-(2-ethanesulfonic acid) (HEPES)-KOH buffer, pH 7.9 (20 mM), 25 mL of 100 glycerol (25 ), 25 mL of 2 M KCl (0.5 M), 150 L of 1 M MgCl2 (1.5 mM), and 40 L of 0.5 M sodium EDTA, pH 8.0 (0.2 mM). Bring to 100 mL with distilled water. Additives Before use add to an aliquot of sonication buffer (e.g., 1 mL) 1 L of 1 MDTT mL (1 mM) and 1X mammalian protease inhibitor cocktail (commercially available from Calbiochem cat. no. 539134) (see Note 1). If state of phosphorylation is important, add 1 L of 1 M NaF mL (1 mM), 1 L of 5 Mokadaic acid mL (5 nM), and 1 L of 100 mM Na3VO4 mL (100 M). 2. Buffer A for crude nuclear extract (100 mL) 1 mL of 1 MHEPES-KOH, pH 7.9 (10 mM), 150 L of 1 M MgCl2 (1.5 mM), 500 L of 2 M KCl (10 mM), 200 L of 0.5 M sodium EDTA, pH 8.0 (1 mM), and 25 mL of 100 glycerol (25 ). Bring to 100 mL with distilled water. Additives Before use add to an aliquot 1 L of 1 M DTT mL (1...
Photographicprinting chemicals
Many of these substances arc highly irritant and corrosive (see overview in Schardein 2000, Gilstrap 1998, Paul 1993). The most commonly used chemicals are acetic acid, ammonium sulfate, ammonium thiocyanate, ammonium thiosulfate, bromine potassium bromide, citric acid, diethylenetriaminepenta acetic acid (DTPA), ethylenediamine tetra acetic acid (EDTA ferric ammonium salt of EDTA), glycol ethers, hydrocarbon solvents, hydroxy-lamine, 3-phenylenediamine, 4 -phenylenediamine, potassium carbonate, sodium benzoate, sodium sulfite, and sulfur dioxide.
Phenoxyacetic acid derivatives and chlorinated dibenzodioxins
In general, maternal blood lead concentrations within the normal range (i.e. 5 ng dl. In adults, the blood lead concentrations regarded as toxic and requiring chelation therapy are in the range of 60pg dl. In pregnant women, blood lead concentrations 30 tg dl would be cause for concern. At concentrations which cause severe maternal toxicity ( 100 .ig dl), an increased risk of fetal loss may occur. In such circumstances, the uterine muscles relax and the fetus is expelled from the uterus. It is not known whether this is due entirely to the high concentrations of lead per se, or whether it is secondary to the maternal toxicity (see overview in Schardein 2000, Rabinowitz 1988, Barlow 1982, Scanlon 1975). In children with brain dysfunction following in utero exposure to lead, the blood concentrations of lead are usually 35 pg dl. Lead concentrations of 40 tg dl in children are regarded as toxic, and require chelation therapy. If indicated, dental amalgam fillings may be restored during...
Antioxidant Scavanger Action
In our own laboratory, we assessed the antioxidant activity of EGb761 in in vitro experiments. The formation of TBA reactive substances (TBARS) was used as an index of lipoperoxidation (LPO) in all forebrain membranes 34 . The degree of peroxidation (lipoperoxidation index LPO) increased gradually with increasing time (30 to 60 min) of incubation in the medium containing 0.1 mmol l FeSO4 EDTA plus 1 mmol l H2O2 mg of protein. The addition of 50 or 100 J.l ml EGb761 significantly protects the generation of LPO products in cerebral membranes. In addition, oxidative modifications in protein measured by the content of total sulfhydryl group level was protected up to 75 to 81 by the addition of 50 or 100 J.l ml EGb.
Other Therapies 1151 Razoxane
Razoxane is a cyclized analog of ethylenediaminetetraacetic acid (EDTA) that was first synthesized in the late 1960s (see Structure 11.5). It has limited activity in the leukemias and is now little used in the clinic. Not surprisingly, line EDTA, razoxane possesses intracellular iron-chelating activity.
Setting Up the RNA Workplace
RNA is very susceptible to hydrolysis by RNases. RNases are present not only in tissues, but on the skin of investigators, and can thus be reintroduced into the preparation at any time. RNases are very difficult to inactivate. They are resistant to metal chelating agents, are active over a wide pH range, and can survive prolonged boiling or autoclaving. Indeed, if autoclaved reagents contain microorganisms, their RNases can be set free during autoclaving. Fortunately, RNases rely on histidine residues for catalytic activity and they can be inactivated by the alkylating agent DEPC, by 3 hydrogen peroxide solutions, 1 SDS solutions, or 1 N sodium hydroxide solutions. Glassware can also be baked at 180 C for several hours. The following steps should be taken before starting to work with RNA
Common Household Chemicals as Urinary Adulterants
Schwarzhoff and Cody studied the effect of 16 different adulterating agents ammonia-based cleaner, L-ascorbic acid, Visine eye drops, Drano, Golden Seal root, lemon juice, lime solvent, Clorox, liquid hand soap, methanol, sodium chloride, tribasic potassium phosphate, toilet bowl cleaner (Vanish, Drackett Products), white vinegar, ionic detergent (Multi-Terge) and whole blood anticoagulated with EDTA on FPIA analysis of urine for abused drugs. The authors tested these adulterating agents at 10 by volume concentration of urine with the exception of Golden Seal because of the insolubility. For Golden Seal tea, one capsule was suspended in 60 mL urine. Out of six drugs tested (cocaine metabolites, amphetamines, opiates, phencyclidine, cannabinoid and barbiturates), the cannabinoid test was most susceptible to adulteration. Approximately half of the agents (ascorbic acid, vinegar, bleach, lime solvent, Visine eye drops and Golden Seal) tested caused false negatives. Both cannabinoid and...
Adverse Reactions and Toxicity
Toxicity of a contrast medium is attributed to its molecular structure, solution property, formulation, and the amount used as a dose. Toxicity may be further classified as chemotoxic-ity, osmotoxicity, and ion toxicity (407, 459). Chemotoxicity is related to a molecular structure that allows binding to proteins, leading to interaction with biomacromolecules such as enzymes, cell membranes, and cell components. Osmotoxicity is attributed to the hyper-osmolality of contrast media, and a marked difference exists between the osmolalities of ionic and nonionic contrast media. Ion toxicity refers to adverse reactions as a consequence of too high or too low ion concentrations in contrast media that interfere with cellular function. Contrast media formulations containing citrate and EDTA buffers can interfere with serum Ca2+ and affect myocardial contractility function. Contrast media are transported by the cardiovascular system and are excreted by the kidneys. Any reactions to contrast...
Plasmodium Iron Sources and Pathways
The Plasmodium parasite requires iron for DNA synthesis, glycolysis, pyrimi-dine synthesis, heme synthesis and electron transport. Debate continues on the critical source of iron for the intraerythrocytic parasite. An important paradox regarding iron is that millimolar desferrioxamine (DFO), an iron chelator, is cytostatic for mammalian cells and bacteria, while a 60-fold lower concentration of 15 M DFO is cytocidal for P. falciparum despite the availability of 20 mM heme iron in hemoglobin (Mabeza et al. 1999). Postulated available sources susceptible to chelation include (1) extracellular iron from transferrin or free iron in the media (2) intracellular iron bound to low molecular weight proteins, heme iron or erythrocyte ferritin iron. Lovesky has identified an intraerythrocytic labile pool of bioavailable iron with the fluorophore calcein (Loyevsky et al. 1999a). In the infected erythrocyte most of the labile pool of iron is in the parasite. In addition, uninfected erythrocytes...
Targeting Hiv Rna with Small Molecules
Far from being a passive carrier of genetic code, RNA is intimately involved in a wide range of biological processes including chemical catalysis and information storage. The vast majority of cellular RNAs form higher order structures with other cellular components to facilitate the exchange of biochemical information. Successful molecular recognition of RNA often precedes catalytic events that are essential to a wide range of cellular activities, including initiation of DNA replication 3 , extension of the telomeric regions of chromosomes 4 , splicing of pre-mRNA 5 , and iron chelation 6 . In addition, RNA serves as the primary genome of most pathogenic viruses 7J.
Organs and Systems Nervous system
There have been reports of taste disturbance in patients taking ACE inhibitors, tentatively attributed to chelation of metal ions. However, no mechanism for taste loss due to angiotensin-II receptor blockers has been proposed. Reversible loss of taste discrimination has been reported with losartan (6). In two cases dysgeusia occurred some time after switching from an ACE inhibitor to losartan (1 week in one case and 3 months in the other). In both cases the dysgeusia disappeared after withdrawal of losartan (timing not reported in one case, 1 week after in the other) (7). The authors referred to previously reported cases, one with losartan (8) and one with valsartan (9), and to a personal communication from the manufacturer of 12 other cases within a large safety monitoring program.
Therapeutic Drug Monitoring of Immunosuppressant Drugs
Whole blood (EDTA) Whole blood (EDTA) Whole blood (EDTA) Whole blood (EDTA) EDTA, ethylenediaminetetraacetic acid. a , 75 , 100 , 100 , 150 The costs are based on published charge for these tests in our hospital laboratory and reference laboratories. EDTA, ethylenediaminetetraacetic acid. a , 75 , 100 , 100 , 150 The costs are based on published charge for these tests in our hospital laboratory and reference laboratories.
Triplex Cleaving Agents
Addition of an EDTA moiety to a triplex-binding ligand can convert it into a triplex-specific cleavage agent in the presence of Fe2+ and a reducing agent. EDTA conjugates, attached to the alkyamino side chain, have been prepared for BePI, BgPI 26 and BQQ 130 . The ligands cleave DNA at sites to which a triplex-forming oligonucleotide is bound, though the background cleavage in non-targeted duplex DNA is greater than that produced by EDTA-tethered oligonucleotides 3 . BgPI and BQQ conjugates produce double-stranded cuts at triplex target sites, cleaving the purine and pyrimidine strands of the duplex with equal efficiency. As a result of their selectivity for triplex DNA these agents can be used to cleave plasmid DNA at a single site to which a triplex-forming oligonucleotide is bound. In contrast BePI-conjugates only cleave the duplex pyrimidine strand while the purine strand is actually protected from background cutting. As a result, this conjugate cannot be used to produce...
Oxidation chemistry of 5ht and da
A widely used HO-generating system consists of AA, traces of Fe2+-ethylenediaminetetraacetic acid (EDTA), H2O2, and molecular oxygen (Udenfriend et al. 1954). In this medium, HO - is formed by decomposition of H2O2 by the Fenton reaction (Walling 1975) and the resulting Fe3+ is reduced back to Fe2+ by AA (equation 1). Thus, as long as AA and H2O2 are available, HO- is formed by this cyclic reaction. When incubated with this HO-generating system, 5-HT is oxidized extremely rapidly (Wrona et al. 1995). The initial step in the reaction involves HO- attack on 5-HT to give the 4,5-(1), 2,5-(2) (1) and 5,6-(3)-dihydroxytryptamine radicals, which are then oxidized by a second molecule of HO- to give 2,5-DHT, 4,5-DHT, and 5,6-DHT in approximate yields of 60 percent, 24 percent, and 11 percent, respectively (figure 1). However, 4,5-DHT is not an isolatable product owing to its very facile oxidation by molecular oxygen to give tryptamine-4,5-dione (T-4,5-D) in a reaction that forms H2O2 as a...
Laboratory Analysis Of Tcas
It is important to stress the need to avoid serum or plasma separator tubes when collecting samples for analysis of TCAs. Nyberg and Martensson (18) studied several types of blood collection tubes for stability of amitriptyline, imipramine, clomipramine, and their mono-demethylated metabolites collected in these tubes. Ethylenediaminete-traacetic acid (EDTA) tubes were most suitable and serum separator gel tubes were unsuitable because of loss of more than 40 of drug concentrations on storage. The losses were not caused by redistribution between blood cells and plasma but occurred mainly because of sample contact with serum or plasma separator gel or the caps of the tubes. Dasgupta et al. (19) studied Greiner serum separator gel tubes for stability of TCAs and many other drugs, and concluded that these tubes are not suitable for blood collection for analysis of TCAs.
Cisplatin carboplatin and oxaliplatin
However, it is still debatable which method most accurately predicts individual values of GFR or creatinine clearance. Whereas the Cr-EDTA method is the most accurate method of estimating GFR, most clinicians do not use it routinely, preferring to collect urine for estimation of creatinine clearance. Alternatively, the use ofspecial formulae has been recommended. A new formula (Wright's formula) may provide a more accurate estimate of GFR than the formulae of Cockcroft & Gault or Jelliffe (27C, 28C, 29c). Furthermore, the formulae used for conventional carboplatin chemotherapy cannot translate into high-dose chemotherapy in terms of prediction of myelosuppression or of response rates, because there is a poor correlation between the calculated and the real serum concentrations ofcarboplatin.
Inhibition of mature osteoclast function, promotion of osteoclast apoptosis, and interference with osteoblast-mediated osteoclast activation. In patients with osteoporosis, pamidronate increased bone mineral density by 6.8 over 2.2 years (11). The frequently observed adverse effects with pamidronate therapy were gastrointestinal gastritis due to either a local reaction when a high concentration of the drug stays in the mucus or by chelation with calcium ions (12).
Specimen Types
Serum and plasma are the most common type of specimen used in TDM. These specimens may be interfered by all four types of interferents covered in this chapter. Additionally, collection tube additives for plasma or whole blood specimens, such as ethylene-diamino-tetra-acetate (EDTA), heparin, citrate, fluoride, and oxalate may chelate metal ions and thus interfere with label enzymes such as alkaline phosphatase and thus generating false-positive or false-negative results.
Several different mechanisms have been suggested to explain the biological activity of the anthracyclines, and controversy still exists about the relative importance of each. The first centers on the fact that the planar ring system inserts between two DNA base pairs perpendicular to the long axis of the double helix, with the amino sugar conferring stability on the adduct through hydrogen bonding interactions with the sugar phosphate backbone. It is known from in vitro experiments that the adduct formed is sufficiently stable to interfere with DNA processing, including transcription. Second, the anthracyclines are known to form complexes (i.e., ternary complexes) with topoisomerase enzymes and DNA, which can lead to strand breaks. Third, binding to cell membranes has been observed, and this may alter membrane fluidity and ion transport as well as disturb various biochemical equilibria in the cell. Lastly, generation of semiquinone species can lead to free radical or hydroxy radical...
10 mM Tris-HCl-1 mM EDTA buffer (TE buffer) 1 mL of 1 M Tris-HCl, pH 7.5, and 200 L of 0.5 MEDTA, pH 8.0, in 99 mL of dH2O. 8. Hybridization buffer 23.8 mL of formamide 0.95 mL of 1 M Tris-HCl, pH 7.4, 0.19 mL of 250 mM EDTA, pH 8.0, 3.75 mL of 4 M NaCl, 9.52 mL of 50 (w v) dextran sulfate, 0.95 mL of 50X Denhardt's solution. Add dH2O to 40 mL and store indefinitely at -20 C.
Ascorbic acid
There is a complex interaction between ascorbic acid, iron, and deferoxamine (157). Ascorbic acid appears to be essential for the mobilization of stored iron into a labile pool, available for chelation therapy. As a result, the administration of deferoxamine to patients with ascorbic acid deficiency will have a limited effect. On the other hand, ascorbic acid increases the toxic effects of iron, especially on the heart. In order to prevent serious cardiac dysrhyth-mias, ascorbic acid should only be given after deferoxamine infusion has been started and adequate serum concentrations of deferoxamine have been reached (SEDA-8, 239) (158). Ascorbic acid reduces ferric to ferrous iron, and it is the reduced iron that is responsible for the generation of highly reactive free radicals, causing tissue injury (157). Ascorbic acid up to 2 g day stimulates deferoxamine-mediated urinary iron excretion, probably without adverse cardiac results (159). However, a report of the precipitation of...
Reduced anticoagulation has been reported in a patient taking warfarin when he was given chelation therapy (25). A 64-year-old man with coronary artery disease taking atenolol, lisinopril, atorvastatin, glyceryl trinitrate, triamterene, hydrochlorothiazide, omeprazole, nizatidine, enteric-coated aspirin, and a liquid multivitamin formulation containing spinach and broccoli extracts was given warfarin for bilateral pulmonary embolism. About 3 weeks later he received chelation therapy with a cocktail including sodium edetate 3 g and heparin 2500 units. The next day his INR had fallen from 2.6 to 1.6. He denied having missed a dose of warfarin, having taken other drugs, or having made dietary changes. The dose of warfarin was increased and the INR reached the target range.
EDTA-anticoagulated whole blood is the recommended specimen matrix (132). This is because almost all of the sirolimus ( 95 ) is concentrated in erythrocytes, and plasma levels are too low for most analytical methods (134). Whole blood samples are stable for 10 days at ambient temperature (141), at least 1 week at 30-34 C (141, 142), 30 days at 4 C (143), and at least 2 months at -40 C (143). Whole blood samples can withstand three freeze-thaw cycles without altering measured sirolimus concentrations (141,142).
Alzheimers Disease
Accumulation of P-amyloid is associated with Alzheimer's disease development its toxicity in cultures of hippocampal neurons is mediated via ROS, lipid peroxidation, activation of the caspase cascade, and apoptosis. When such cells were co-exposed to EGCG, incidence of the latter three events decreased in a manner independent of p53, Bax, Bcl-xL, and cyclooxygenase (COX) 7 . The cytotoxicity of amyloid proteins appears to rely largely upon the formation of well-ordered fibrillar assemblies. Polyphenols inhibit this formation independently of their antioxidant activity 8 . Iron chelation by EGCG also reduces the aggregation of a major component of neurofibrillary tangles, hyperphosphorylated tau, in the brains of these patients 9 . ROS generation is partially dependent upon processes requiring intracellular iron, including the Fenton reaction. Dysregulation of cellular iron homeostasis, including uptake, distribution, transport, and storage, is a causal factor in the patho-genesis of...
Elevated toxic element concentrations in a specimen should always be confirmed with secondary testing to ensure that the elevated result was not due to external contamination. Sources of external contamination include collection materials, the specimen donor, the environment, transport containers, or assay reagents. As a result, certified trace element-free blood collection containers are available. Royal-blue top blood collection tubes, available with or without anticoagulant, are certified as trace element-free for most clinically important elements. Tan top tubes ethylene diamine tetra acetate (EDTA) anticoagulant are certified as lead-free, so can, in addition to the royal blue tubes, be used for lead testing. Laboratories that perform trace element testing are often physically isolated from other laboratory areas, and pay particular attention to sources of external contamination such as labware materials, dust control, and airflow dynamics. Certified trace metal-free reagents are...
Chelation therapy with intravenous desferoxamine is indicated if the serum iron level is 55 n mol l or if an overdose was clearly taken and the pregnant woman develops seizures, is unconscious, or presents with circulatory shock. In these cases, there is not time to wait for serum iron levels.
Carbomers are acrylic acid polymers that are used for a variety of purposes. They are used in pharmaceutical processes as suspending agents, gel bases, emulsifiers, and binding agents. They are also used as artificial tears. Carbomer 974P is a carbomer that is the major non-aqueous component (5 polymer, 94 water) of a proprietary formulation called BufferGel, which also contains dibasic potassium phosphate, magnesium sulfate, dibasic sodium phosphate, sorbic acid, monobasic sodium phosphate, and disodium EDTA. It is a buffering agent, a microbicide, and a spermicide. It is formulated in an aqueous gel at pH 3.9, which acidifies twice its volume of semen to a pH of 5 and maintains the protective acidity of the vagina. It is used vaginally as a spermicide that also protects against HIV infection and possibly other sexually transmitted diseases.
Detecting Monoamines
Twenty-minute samples were injected, without any purification, in a HPLC equipped with a reversed-phase ODS column (LC 18 DB Supelcosil, Supelco, Bellefonte, PA) and an electrochemical detector (BAS, Lafayette, IN) to quantitate DA, 3,4-dihydroxyphenylacetic acid (DOPAC), and homovanillic acid (HVA). The mobile phase was 0.23 M sodium acetate, 0.015 M citric acid, 100 mg L EDTA pH 5.5. The electrode used was a silicon carbon paste TL-3 working electrode with potential set at +0.65 V in oxidation, coupled with an Ag AgCl reference electrode. Experiments were always performed 24 h after probe implantation. Perfusion Ringer (147.2 mM NaCl, 3.4 mM Ca Cl2, and 4 mM KCl) flow was 2 L min (11). Dialysate samples (10 or 20 L) were injected without purification into an HPLC equipped with a reversed-phase column (LC-18 DB, 15 cm, 5 m particle size Supelco) and a coulometric detector with a 5014 A cell (ESA Coulochem II, Bedford, MA) to quantitate DA and NA. The first electrode of the detector...
Iron Fe
Fe is unavailable to plants when the pH of the water or soil is too high. If deficient, lower the pH to about 6.5 (for rockwool, about 5.7), and check that you're not adding too much P, which can lock up Fe. Use iron that's chelated for maximum availability. Read your fertilizer's ingredients - chelated iron might read something like iron EDTA . To much Fe without adding enough P can cause a P-deficiency.
Mercury contamination from dental amalgam does not lead to dramatic increases in heavy metal concentrations that would demand consequences such as weaning. Detoxification treatment is not indicated. In addition, chelating agents may mobilize heavy metals and in this way increase contamination of the mother's milk. On the other hand, amalgam fillings should only be removed in case of dental problems. Extensive restoration should be postponed until after the breastfeeding period. Wherever possible, amalgam should be avoided. However, at an individual level, the amalgam issue should not be stirred up into a toxicological crisis that puts an unjustifiable strain on the mother-child relationship.
For quantitation of tacrolimus, EDTA-anticoagulated whole blood is the specimen of choice for the same reasons provided for CsA. Whole blood samples are stable for 1 week when shipped by mail without coolant (98,99), 1-2 weeks at room temperature (99,100), 2 weeks at refrigerator temperatures (100), and almost 1 year at 70 C (100).
DNA strand cleavage
Oxidative stress by hydroxyl radical also causes direct DNA damage, mainly by strand cleavage and oxidation of pyrimidine and purine bases. DNA, because of the negative charge of its phosphate groups, acts as an anion and is therefore capable of binding many cations, including those required for Fenton chemistry, like Fe2+ and Cu+. Additionally, deoxyribose has also good iron-binding properties. This allows ''site-specific'' hydroxyl radical generation that cannot be countered by radical scavengers. Perhaps for this reason, antitumor compounds that act by DNA strand cleavage are also normally chelating agents.
Also, incubating 1 ml specimen with 10 l of alkaline phosphatase enzyme (Sigma Chemical Company, St. Louis, MO, USA) converts any fosphenytoin present in the specimen to phenytoin within 5 min at room temperature. This procedure eliminates interference of fosphenytoin in phenytoin immunoassays. The authors observed complete conversion of fosphenytoin to phenytoin by alkaline phosphatase in heparin, ethylenediaminetetraacetic acid (EDTA), and citrated plasma (16).
Parkinsons Disease
A number of polyphenols, including EGCG, function as antioxidants at low concentrations 5 . Some of their actions involve scavenging ROSs (discussed below) and induction of endogenous antioxidants via PKC 16 . ROS generation via iron dysregulation plays a role in Parkinson's disease. Toxic a-synuclein aggregates form after exposure to redox-active iron both occur within Lewy bodies, characteristic of Parkinson's disease 12 . As in Alzheimer's disease, iron also regulates degradation of IRP in Parkinson's disease. Decreased amounts of IRP lead to decreased transcription of the transferrin receptor, and thus increases in the iron transport protein, ferritin. Mice lacking the IRP gene accumulate iron in their substriatia and develop symptoms of Parkinson's disease, including tremor and bradykinesia. EGCG prevents accumulation of a-synuclein and decreases removal of IRP in murine models of Parkinson's disease 1 . Iron chelation may thus contribute to EGCG's neuropro-tective effects in...


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Department: Ecodata Management
Geographical information systems (GIS) play a central role in the management of spatial information. We master the full set of methods for collecting and archiving primary spatial data, from scanning and digitizing maps to the processing of GPS-data.
Our expertise includes the import of spatial data from external systems (e.g., geometry data from CAD and mapping systems, GIS data from various database systems, and remote sensing data from imaging systems). By applying special software, we can transform various national and international coordinate formats at high quality, with or without date changes. Using geostatistics and data mining, we can create statistically validated spatial extrapolations and habitat models.

subset: commoncrawl


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You are here
Sinanan denies ethnic cleansing claims
Works and Transport Minister Rohan Sinanan has denied claims of ethnic cleansing of T&T's East Indian community via the property tax.
He did so in response to questions from reporters when he attended the Sanatan Dharma Maha Sabha's (SDMS) Indian Arrival Day dinner at the Radisson Hotel, Port-of-Spain, on Saturday night.
Prof Dilip Dan, head of the Department of Clinical Sciences at The UWI, who was honoured at the event, had referred to ethnic cleansing and claims that the reintroduced property tax targeted East Indian when he spoke at the function.
However, Sinanan said ethnic cleansing had no place in T&T and was not a factor in any of Government's decisions. He added that traditionally East Indians have always been comfortable paying property taxes.
In his address, in which he focused on ethical leadership, Professor Dan said although the majority of T&T's scholars are of East Indian origin, they make up only 18 per cent of corporate T&T and major Government posts are not proportionately obtainable by that ethnic group.
He also said most cases of racial prejudice had been adjudicated by the courts and pointed out that Radio and TV Jagriti, media outlets operated by the SDMS, had faced many legal battles.
SDMS Secretary General Satnarayan Maharaj said the organisation's schools, which had once been described as cow sheds, are now the prefered schools in the country.
He said Lakshmi College had been called a "see through" college because at one time its administrators couldn't afford doors and windows but had broken every record in the Caribbean for three consecutive years by winning the President's medal.
Maharaj added that SDMS schools will not close down due to a lack of Government funding because they are self reliant and raise their own funds.
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Guardian Media Limited accepts no liability and will not be held accountable for user comments.
Guardian Media Limited reserves the right to remove, to edit or to censor any comments.
Any content which is considered unsuitable, unlawful or offensive, includes personal details, advertises or promotes products, services or websites or repeats previous comments will be removed.
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User profiles registered through fake social media accounts may be deleted without notice.


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Appen skickades inte till din enhet eftersom vi har problem med kommunikationen med våra servrar. Försök igen senare.
Den här appen kräver en uppdatering av din {0}. Använd Garmin Express för att uppdatera din {0}.
This App brings back the "Pace Datafield" like you know it from older Garmin products like the Forerunner 405.

The pace (min:sec per km or min:sec per mile, depending on the paceUnit settings) is displayed in 1 second steps (NOT in 5 second steps).

The Datafield shows the last measured speed value (no avarage, not smoothed).

Version SDF 1.7.0 brings support for new Garmin Devices available in 08/2019

Den här appen måste ha åtkomst till:
Simon Brewster
den 21 maj 2020 | Version SDF 1.7.1
Used for fenix 5 plus to replace pace which has been smoothed, perfect drop in for existing data screens - does exactly what it says
Simon Gough
den 4 november 2019 | Version SDF 1.7.1
Superb app. Does exactly what's expected and with a footpod brilliant for pacing
den 13 oktober 2019 | Version SDF 1.7.1
With my garmin fenix 5 it worked perfectly. But with the garmin fenix 6 zafire version it blocks the device and I have to shut it down. Then I have to remove this App, if I don´t do so the problem persist.
Svar från utvecklaren
den 13 oktober 2019, lohrm
Thanks for your information. At the moment I do not have a fenix 6 for physical testing (will bye a 6x Solar as soon as available) and can only use the simulation tool provided by garmin. There is no differnce in the data field coding between the devices. Maybe it's a bug in the Fenix 6 firmware or the IQ-runtime. Will try it out as soon as possible and if necessary I will adapt the coding. But have to wait for availability of Fenix 6x Solar. Will take a while. Sorry
Chris Hubbard
den 7 juni 2019 | Version SDF 1.6.2
I've been using this datafield on my 920XT for years - it's really helpful for intervals. I just upgraded to a 945 and forgot how annoying the default Garmin pace field is. Hoping I don't have to wait too long to get an update that supports the 945.
Mike Luke
den 2 april 2017 | Version SDF 1.4-upd1
This was the best app on my 920XT. I have just bought a 935 and am lost without it, I hope it is available for the 935 soon.
Giuliano Setzi
den 26 november 2015 | Version SDF 1.3-upd_J
den 4 oktober 2015 | Version SDF 1.3-upd_J
Works well on my vivo active. I like being able to look down and see what pace I'm running at that moment. The "current pace" on my Garmin 910 varies a lot. I've learned to ignore any readings that appear too fast or too slow for my perceived pace at that time. I've run with both the VA running the exact pace App, and my 910. The exact pace App appear to be more in line with what I am actually running at that moment. It will stay pretty steady, while my 910 will bump up and down quite significantly. Used the Exact Pace App on my VA for a 5k today and set a PR, in part, because I had the confidence to trust my pacing and didn't push harder needlessly because my 910 said I was running slower, or have a false sense of going fast enough when the 910 was running "fast".
Karl Watanabe
den 18 januari 2015 | Version ExactPace SDF v1.0
This worked pretty good. Actually shows the 5 sec default pace is also good because the 'exact' pace was just a few seconds +/- different. It does record the pace calculated from the 920 which has been filtered. Would be interesting to see gps calculated pace not filtered.
Det finns tyvärr ingen statistik tillgänglig ännu.


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Author : Cyph
in the following tutorial you will learn how to create Jordan Ruddess lead sounds for Korg synth with EDS synthesis (Korg M3/M50 and for our beloved Krome!)
It is a very long video but it deserves watching !
You will be able to create 4 programs and combination :
5:17 Program 1 - JR Lead Main
9:41 Program 2 - JR Pulse Sub Wave
13:17 Program 3 - JR Saw Sub Wave
15:33 Program 4 - JR Triangle Sub Wave
17:52 JR Lead Combi - Basic Setup
23:16 JR Lead Combi - Heavy Metal distortion (first IFX)
30:12 JR Lead Combi - Chorus (second IFX)
32:31 JR Lead Combi - Heavy Metal feedback (third IFX)
37:21 JR Lead Combi - Delay (MFX 1)
40:28 JR Lead Combi - Reverb (MFX 2)
You just need the Krome Editor to do the same on your PC / Mac...Many menu are quite similar on Krome editor, so just do it !!! and share your results with us !


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OKVHS Virtual View
April Newsletter
Inside This Issue
- Online Students Have Talent!
- Art Contest
- Your Voice Student Poll
- Student Spotlight
Memory Techniques for Learning From "Mind Tools"
- April Showers Bring Tornado Season
- Road to Relaxation
- Alcohol Awareness Month
- 2014 Summer Academies in Math, Science and Technology
- When I Grow Up
- Goal Setting- Smart Goals
Parent Corner
- Graduation Information
- Official Transcripts
- End of Instruction Exams (EOI's) Are Coming Soon!!
- Pre-Enrollment Information
- KidsHealth eNewsletter Invite
Online Students Have Talent!
Check out two of our online students, Sophia and Grace Babb, which make up the duo, Annie Oakley! Having played venues, events, and festivals that expanded their following with every performance, these 16-year-old twins released their debut EP, Annie Oakley, in December 2013. Their music and compelling harmonies have a soulful, indie-folk feel that has been described as coming "straight from the heart." Annie Oakley has a lot of events coming up in April! For more information on Annie Oakley, and to see a list of upcoming events please visit http://theannieoakley.com/upcoming-events.html
Thank you for sharing your talents!
Tell us who you think should win the Art Contest!
Your Voice Student Poll
In the March Newsletter we asked, "What is the best April Fool's joke you've played on someone/someone has played on you?" Here's what you had to say:
- One thing that I love to do is grab all of my friends' cell phones and change the language setting to a foreign language.
- One year, while my mom was at work, I hard boiled all of the eggs in the carton and put them back in the refrigerator. It paid off for me! I love egg salad sandwiches.
- Last year I put food coloring in all of our hand soap dispensers. This was also a great way to catch people that didn't wash their hands!
- My sister is obsessed with the Hunger Games, so this year I'm going to change her contacts in her cell phone to the names of the Hunger Games characters. Katniss Everdeen calling!
- The best April fool's joke I have done was last year. Since my mom doesn't like the taste of our water at our home she gets water in the bottles and we filter those so I changed out all of the water bottle's water with white vinegar. Let's just say she didn't find it funny... but the rest of the family did!
Thank you to everyone that submitted a response! We hope you had a fun and safe April Fool's!!
We want to hear YOUR VOICE! It's time to share your comments with your fellow students, teachers, counselors, and Student Achievement Coordinator. We can't wait to hear what YOU have to say!! This month's question is:
Student Spotlight
This month's OKVHS Student Spotlight is on Donny Skaggs. We appreciate Donny so much for not only being far ahead of his expected pace for on time completion, but for also making good grades while doing so! We recently asked Donny some questions, and this is what he had to share.
OKVHS: What study tips or strategies do you use that allows you to be successful in this program?
Donny Skaggs: To be successful I make sure that I work on every subject every day. I also use a lot of notes and read over them carefully
OKVHS: What hobbies, talents or extra-curricular activities do you participate in (besides your school work)?
Donny Skaggs: In my free time I fish, hunt (in season) and study Brazilian Jui-Jitsu three times a week.
OKVHS: What attracted you to attend OKVHS?
Donny Skaggs: In public school I did not like the environment. I didn't like the other students' attitudes towards teachers and how they disrupted class. This took away from my learning time and that's the reason I was there (to learn).
It is always nice to talk to such a positive, well-mannered young person who is a shining example of what we look for and appreciate as a student. Congratulations, Donny!
We hope to spotlight YOU in next month's newsletter!
Memory Techniques for Learning from "Mind Tools"
On your path towards an education, you'll be required to study and process a huge volume of information. In order to become more effective at learning this information, and in order to make the process easier there are memory techniques or "Mind Tools" which can be practiced daily on your quest to becoming a successful student.
Memory techniques can be used to help you both remember facts accurately and to remember the structure of information. These tools can be split into two sections:
- The memory techniques themselves.
- How you can use them in practice.
Memory Techniques
"Mnemonic" is another name for a memory tool with the idea of using creativity to encode difficult to remember information in a much easier way. For example, a rhyming Mnemonic to help you remember an important date is, "In 1492, Columbus sailed the ocean blue." A name mnemonic uses the first letter of each word in a list of items to make a name of a person or thing, like ROY G. BIV, which helps you to remember the colors of the spectrum (Red, Orange, Yellow, Green, Blue, Indigo, Violet).
How to Use Memory Techniques
Use your whole mind to remember things by creating vivid mental images which can reliably store both information you are trying to remember and the structure of that information. Because these images are vivid, they are easy to recall when you need them.
Here are a few tips that may help make the mnemonic techniques you use more memorable:
- Use positive, pleasant images. Remember that your brain often blocks out unpleasant memories. For instance, What is a numismatist? Visualize a new mist rolling onto a beach from the ocean and the beach is made of coins. This pleasant image helps you to remember that a numismatist is a coin collector.
- Use vivid, colorful, sense –laden images-these are easier to remember than the bland ones.
- Try using humor. Funny things are much easier to remember than normal ones. For instance, picture two numismatists meeting for dinner for "old dime's sake."
The three essential principles of using mnemonics are imagination, association, and location:
- Imagination- The more strongly you can imagine and visualize something, the more effectively you are able to recall it at a later time.
- Association-This is a way of linking certain things together to help you remember the subject matter. For instance you might imagine a depressed bat in order to help you remember that the depressant drugs are Barbiturates, Alcohol, and Tranquilizers.
- Location- gives you two things: a clear environment into which you can place information so that it is grouped together, and a way of sorting out one mnemonics from another. For example, by setting one mnemonic at the beach and another mnemonic with images of night, you can separate them with no danger of confusion.
These are just a few examples of ways to use your on personal "Mind Tools" to help elevate the educational learning process. Understanding and practicing techniques such as these are not only useful with school and education, but can also be valuable in everyday life.
April Showers Bring Tornado Season
Hey, Oklahoma students! Unfortunately we all know what time is coming very soon. No, we are not talking about summer break just yet. It's tornado season. Some of you may have been affected by the horrible tornados last year, or know someone that went through them. Tornados are violent forces that can get up to 300 miles an hour, and even miles long in length. Tornados are ranked from F0 to F5, with F5 being the strongest. Here is a great link with FAQs about tornados and tornado safety: http://www.spc.noaa.gov/faq/tornado/#Safety
We want to ensure all of our OKVHS students and families are ready for the upcoming tornado season, so here are some great tips on preparing for a tornado:
- Listen to and watch your local news. With the rise of technology and apps for your phone dedicated to live streaming and up to the second alerts, access to local news and alerts couldn't be easier for most families.
- Listen to NOAA Weather Radio. The weather radio has a network of stations from across the nation, broadcasting updated weather information from the National Weather Service. Here is list of the stations for different areas in Oklahoma: http://www.nws.noaa.gov/nwr/stations.php?State=OK
- Research your local communities warning system. Each town might have a different way of updating and warning people. Most towns have sirens that go off during a tornado warning indicating the need to take cover.
- In your home, practice a tornado drill, in case one comes without much warning. Also pick a safe room in your home where you and others can meet. Typically a basement or storm shelter is best, but if not available, find an interior room that doesn't have windows and find the lowest point of the floor.
- Be aware of what objects are around you. Remove or secure items that would be a danger to you or others if they were mobile in the air.
- If you are in an area where you don't have access to information via phone, radio, or television, then please keep your eyes and ears on the lookout for:
- Wall clouds which are the lowering base of a thunderstorm
- Hail or even clouds of debris
- Overwhelming roaring sounds
- Funnel clouds, or any visible extension of the base of the cloud. These will generally be in a very obvious rotating format.
Most of these details can be found through resources like The American Red Cross. For more information on tornados or other types of emergencies, please click on this link: http://www.redcross.org/prepare/disaster
If you have experienced a tornado, or have additional safety tips that you would like to share, then please contact your SAC or counselor. We wish you all a safe Spring!
Road to Relaxation
Ugh! You have a slight problem: There are only a few more weeks left until you have to complete all of your courses by the semester deadline. Well, don't stress out! The simple remedy is you need an arsenal of practical stress solutions that will knock out that pain in your neck, knot in your stomach, or a dozen other symptoms of stress you may experience. Here are five freebies for you:
Blow it off.
Simple deep, slow breathing can often calm the fight-or-flight response during periods of big-time stress. Usually, it takes a few seconds to feel the difference. Simply breathe through your nose while comfortably expanding first your tummy and then your rib cage. (Imagine that you are inflating a beach ball inside your gut through your navel.) Then release the breath through your nose (more slowly than you let it in) and silently say, "Hawaii" (or a word that immediately will relax you).
Crack up before you crack!
A good laugh may break up even teeth-clenching tension. Research indicates that laughter prompts the brain to release endorphins, the body's natural pain relievers. One trick you can use is to keep a great comedian or some bloopers in your favorite you tube folder. When you start thinking about the chemistry exam, just push play…it really works!
Quick muscle release
In about three minutes, you can do this to relax your muscles: First step, sit and close your eyes. Second step, inhale, and hold your breath for about 6 seconds while tensing as many muscles as you can. Third step, simply exhale with a "whoosh" and let your body go limp, then breathe rhythmically for about 20 seconds. Repeat these steps twice, and after the third release, relax for a minute, concentrating on happy thoughts.
Talk to yourself
It's not a sign you're crazy. In fact, it could help you avoid ending up that way. A private dialogue with your ego is a helpful way to handle stress. You are less likely to have tunnel vision about a problem when you give yourself a chance to hear, question and think out loud what you're saying to yourself.
Turn on the tunes
Some experts say that music for relaxation should be slow, quiet and instrumental. But don't despair if you get bored with Brahms or feel like punching someone after listening to drippy elevator music. The most important characteristics of tranquilizing music are familiarity and preference. That means Motown or Meathead, Ella Fitzgerald or Eminem – whatever makes you happy.
Even if you follow one of these tips and tricks, you'll probably feel wired every once in a while. That's just the natural fact, Jack. We have evolved to operate at peak efficiency under a certain amount of stress. The idea is simply to balance the excess stress with some deliberate mellowness. Best wishes to you for the rest of the semester!!
Alcohol Awareness Month
April is Alcohol Awareness Month. Do you or someone you know, drink alcohol? Take this self-test to discover if this is a problem for you or anyone else in your life.
make about alcohol and drugs. The decisions you make about alcohol and drugs will influence your health, your grades, your relationships, your job or career, or your freedom. Not to be too dramatic. . . but these are life and death decisions.
Bottom line – you are responsible for your own safety…what are you going to do?
Before we review our Ten Tips for Prevention--Youth, there are two important points to be aware of:
Age of First Use of Alcohol and Drugs:
Using alcohol and drugs before the brain has fully developed increases your risk for future addiction to alcohol and drugs dramatically. Young people who start drinking alcohol before age 15 are 5 times more likely to develop alcohol abuse or dependence than people who first used alcohol at age 21 or older. Research for drug use and drug addiction have found similar results.
Family History of Alcoholism or Drug Addiction:
Whether a person decides to use alcohol or drugs is a choice, influenced by their
environment -- peers, family, and availability. But, once a person uses alcohol or drugs, the risk of developing alcoholism or drug dependence is largely influenced by genetics. Alcoholism and drug dependence are not moral issues, are not a matter of choice or a lack of willpower. Plain and simple, some people's bodies respond to the effects of alcohol and drugs differently. If you have a family history of alcoholism or addiction, you are four times more likely to develop a problem. To learn more: Family History and Genetics.
So then, as a young person, what can you do to protect yourself and reduce the risk of
alcohol and drug problems? Here are Ten Tips for Prevention--Youth:
- Don't Be Afraid to Say No: Sometimes, our fear of negative reaction from our friends, or others we don't even know, keeps us from doing what we know is right. Real simple, it may seem like "everyone is doing it," but they are not. Don't let someone else make your decisions for you. If someone is pressuring you to do something that's not right for you, you have the right to say no, the right not to give a reason why, and the right to just walk away.
- Connect With Your Friends and Avoid Negative Peer Pressure: Pay attention to who you are hanging out with. If you are hanging out with a group in which the majority of kids are drinking alcohol or using drugs to get high, you may want to think about making some new friends. You may be headed toward an alcohol and drug problem if you continue to hang around others who routinely drink alcohol, smoke marijuana, abuse prescription drugs or use illegal drugs. You don't have to go along to get along.
- Make Connections With Your Parents or Other Adults: As you grow up, having people you can rely on, people you can talk to about life, life's challenges and your decisions about alcohol and drugs is very important. The opportunity to benefit from someone else's life experiences can help put things in perspective and can be invaluable.
- Enjoy Life and Do What You Love - Don't Add Alcohol and Drugs: Learn how to enjoy life and the people in your life, without adding alcohol or drugs. Alcohol and drugs can change who you are, limit your potential and complicate your life. Too often, "I'm bored" is just an excuse. Get out and get active in school and community activities such as music, sports, arts or a part-time job. Giving back as a volunteer is a great way to gain perspective on life.
- Follow the Family Rules About Alcohol and Drugs: As you grow up and want to assume more control over your life, having the trust and respect of your parents is very important. Don't let alcohol and drugs come between your and your parents. Talking with mom and dad about alcohol and drugs can be very helpful.
- Get Educated About Alcohol and Drugs: You cannot rely on the myths and misconceptions that are out there floating around among your friends and on the internet. Your ability to make the right decisions includes getting educated. Visit Learn About Alcohol and Learn About Drugs. And, as you learn, share what you are learning with your friends and your family.
- Be a Role Model and Set a Positive Example: Don't forget, what you do is more important than what you say! You are setting the foundation and direction for your life; where are you headed?
- Plan Ahead: As you make plans for the party or going out with friends you need to plan ahead. You need to protect yourself and be smart. Don't become a victim of someone else's alcohol or drug use. Make sure that there is someone you can call, day or night, no matter what, if you need them. And, do the same for your friends.
- Speak Out/Speak Up/Take Control: Take responsibility for your life, your health and your safety. Speak up about what alcohol and drugs are doing to your friends, your community and encourage others to do the same.
- Get Help!: If you or someone you know is in trouble with alcohol or drugs, (What to Look For), get help. Don't wait. You are not alone.
For additional information, Learn About Alcohol, Learn About Drugs or Get Help may be helpful.
2014 Summer Academies in Math, Science and Technology
This summer, spend time at an Oklahoma college or university and discover the fascinating worlds of aeronautics, engineering, environmental conservation, forensic science and much more!
Summer Academies are FREE!
Be sure to request applications from the contact person listed under the academy you choose. Or call 1.800.858.1840 for more information. See the full list of 2014 academies and select your grade for fall 2014 or visit the individual grade pages from the menu on the left.
When I Grow Up
Know what you are going to do after high school? Overwhelmed on where to start? Ever wished there was one place you could go to get career information? Do you know how much money you will make in your chosen career path or how many jobs are available? Want to make a lot of money, but not sure what jobs might make that much money? All of these questions and more can be answered by visiting the US Department of Labor and Statistics Bureau of Labor Occupational Outlook handbook.
This website offers the answer to all of the above questions – or can at least get you started and thinking about what might be out there. Take a moment to check it out – it will be time well spent.
Goal Setting- Smart Goals
Setting goals is an important part of our everyday life. Goals can be small and achievable in the same day, or they can be big and multi-dimensional goals that can take lots of time and preparation, which can take years to accomplish. Whatever goal you have in mind, here are a few helpful tips when setting those goals and achieving them.
- Specific—Keep the focus of your goal narrow.
- Measurable—How will you know if you are meeting your goal?
- Attainable—Set reasonable, realistic goals.
- Relevant—Set goals that will change your life in ways that you want.
- Time frame—When will you meet your goal?
Choose categories that are important (social, family, personal, school, physical, etc.), create goals that fit into one of the categories, and then prioritize the goals. Remember, no goal is too big or small, follow the SMART Goal guidelines and set a goal today!
Parent Corner
Graduation Information
For Details follow the link:
Or Contact Pam Beck at 405-749-4550
Official Transcripts
End of Instruction Exams (EOI's) Are Coming Soon!!
Spring End of Instruction Exams (EOI's) will be coming up starting April 15th through April 30th. This testing is MANDATORY.
Please click here for more testing information.
Pre-Enrollment Information
- Please click on the link to fill out pre-enrollment information for the 2014-2015 school year. (Please note that the web link is not compatible with Firefox, and works best with Internet Explorer or Google Chrome. )
We know your education is important to you. We are excited you have chosen Oklahoma Virtual High School and will continue to work hard to ensure you have every opportunity to earn your high school diploma. If you have any additional questions about the pre-enrollment process, please contact our Admissions Office at 1.888.425.7178.
We look forward to another great year!
KidsHealth eNewsletter Invite
In our efforts to provide guidance in the area of Personal and Social skills, we are inviting you to take a look at the kidshealth enewsletter provided by www.kidshealth.org. KidsHealth is the most-visited site on the Web for information about health, behavior, and development from before birth through the teen years. One of the things that makes KidsHealth special is that it's really three sites in one: with sections for parents, for kids, and for teens. KidsHealth also provides families with perspective, advice, and comfort about a wide range of physical, emotional, and behavioral issues that affect children and teens. We encourage you to explore their website, sign up for the free enewsletter, and see how it can be helpful for you. Below are some direct links to specific articles in the KidsHealth enewsletter on Emotions.
For Parents:
It's natural for all kids to worry at times, and because of personality and temperament differences, some may worry more than others. Luckily, parents can help kids manage worry and tackle everyday problems with ease.
For Teens:
Emotions help us relate to other people, know what we want, and make choices. Even "negative" emotions are useful. Find out how to understand emotions and use them effectively.


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Replacement or Spare lenses for the popular Uvex Racer Goggle. The racer goggle is one of the most comfortable of all the race goggles with a very large selection of replacement lenses available in both double and single lens format.
Available in:
FREE UK Mainland Standard Delivery (3 - 5 days) on all orders
FREE Click+Collect Order online and collect from your local store for free
UK Mainland express delivery (1-2 days) from £6.50
Orders received before 12pm Mon - Fri will be dispatched same day.
If you are purchasing ski's and bindings and require them to be mounted please provide mounting details in the notes box at the checkout. to mount bindings we require the skiers; age, weight, height, ability level and boot sole length (in mm stamped on the boot). Ski orders recieved without mounting information will be dispatched un-mounted.
Find out more about delivery and charges
No additional taxes or charges apply if your parcel is delivered inside the EU. For countries outside the EU, local import duty and tax may apply. Any such charges must be paid by the customer. Please check with your local tax authority before placing your order.
Returns Period - We will happily refund or exchange any item purchased from Ski Bartlett within 14 days. Exceptions apply to certain products such as ski's that have bindings fitted.
Exchanges – For a speedier exchange, we recommend that you return your original item for a refund & reorder online.
Ways to return your goods:
Return to store FREE
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We are also combining this week's release with the new challenge over at A Day For Daisies Blog. The new challenge theme is a color challenge and here are the colors.
I love those pretty warm autumn colors! =)
The image that I used is called Flower Dreams and it's printed on Papertrey Ink's Rustic White cardstock, colored with Copic markers then trimmed to size.
The patterned paper is from Yearbook 6x6 Paper Pad by Studio Calico and the sentiment is from Papertrey Ink.
That's all I have for now. Don't forget to find out what the other design team members came up with for this challenge here. You can find all the newly released images here.
cardstock: (Rustic White, kraft) Papertrey Ink
digital stamp: A Day For Daisies
clear stamp: (sentiment) Papertrey Ink
patterned paper: Studio Calico
dye ink: (Smokey Shadow) Papertrey Ink
fiber: (cream crochet thread) DMC, (lace trim)
accent: (cream button) Papertrey Ink
tool: (sewing machine)
other: (foam tape) 3M
Copics used:
skin: E13, E11, E01, E00, E000, R20
hair: E27, E25, E23, E21
dress: E19, E09, R27, R24
boots: W9, W7, W5
daisies: YG97, YG95, YG93, YR18, YR16, YR15, YR12
ground: E59, E37, E35, E33, E31, E30, E0000, 0
card size: 4" x 5 1/2"


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Hey all! Jewelle {aka mrspotts} here with the second part of my learning activities series. My two year old daughter is just starting to recognize the letters of the alphabet. But she keeps getting confused about why there are two a's, two b's, etc. I patiently explained to her that there are uppercase letters and lower case letters. She was excited about the concept and wanted to practice telling these letters apart. I devised a learning activity for her called "Feed the Monster." I thought I would share with you how to make one yourself! Here's what it looks like:
Before we get started I want to remind everyone that this hybrid project is a bit more advanced. However, don't let that scare you away! Advanced just means we aren't going to be strictly printing and cutting. We also have to glue, fold, and punch some things out. Give it try, it really is fairly simple! Ready to learn how to make a "Feed the Monster" for your kiddos?! Lets get started then!
Supplies Needed:
- Oogly Boogly & Sketchbook Pages by Kate
- Milk Carton 1 by Kaye Winiecki
- Presentation paper
- Precision Scissors
- 1 1/2″ circle punch
- Modge Podge
- Foam Brush
- Adhesive {I suggest Red Line Tape}
- 1 1/2″ wood nickels
- Exacto Knife
- Bone folder
- Dimensional adhesive
- Score Board {optional}
1.Open the milk carton PSD file in Photoshop. Decorate the milk carton using Kate's doodles. I kept my milk carton simple. I clipped a purple Sketchbook Page to the base of the milk carton.
2. Next open up the monster doodle from Kate's Oogly Boogly set. To alter the monster's smile I used a combination of the magic wand tool and content aware fill in Photoshop. This took a fair amount of manipulating to achieve this gaping smile. A simpler alternative to this would be to use the content aware fill to actually "erase" the monsters smile. Then after printing hand draw the smile on yourself. Choose what method you are most comfortable with!
3. Drag your monster onto your milk carton. Arrange the monster so that he is filling the third column of the milk carton. I wanted my monster to fill the whole face of the milk carton so I had to enlarge him a bit. Once satisfied with your monster, duplicate that layer. You should now have two monster layers that are identical. Using the eye button, hide your topmost monster. Using the rectangle marquee tool, begin selecting and deleting any part of your monster that will not be on the face of the milk carton.
4. Now it's time to change the hue of the folds and trims layer so they are less noticeable. To do this click on your foreground tool. Using the eye droper choose a color from your milk carton. Once chosen choose a new hue of that color that is darker. I went a little to the right and little down to get my new hue. Then click okay. Make sure you have selected the folds and trims layer of your milk carton. Then go Edit —> Fill —> Ok. You can see in the picture that my lines are now dark purple instead of black.
At this point you could just print your milk carton. I chose to erase a bunch of the fold and trim lines so they would not be visible when the carton is assembled. Go ahead and skip this step if you need those lines!
5. Print your milk carton. NOTE: Do not turn on the full body monster layer! We do not want it to print directly onto the milk carton.
6. Cut out your milk carton. Score fold lines using your bone folder and a score board. At this point we are going to change the design of the milk carton slightly. Turn your milk carton over so the white side is facing up. Using the red line tape adhere all your bottom flap pieces to the inside of the milk carton. This will make it so there is no bottom to the milk carton and you can easily retrieve your letters the monster eats.
Flip the milk carton back over and using your exacto knife trim out the monsters mouth. Finish assembling the milk carton using the red line tape. I found pinching the milk carton top pieces together first helped the assembly go smoother. Just be patient with the paper and don't force it to bend.
7. Go back to the milk carton file. Turn your full body monster layer back on by clicking the eye button. Drag him to a new 8.5″ x 11″ document. DO NOT alter his size! On the same file use the elipse tool to create a 1.5″ circle and also a 1.25″ circle. Clip a colored digi paper to the 1.5″ circle. For the 1.25″ circle clip a white digi paper to it. Move the white circle on top of the colored circle. Using the text tool, "write" a letter on the white circle. I used the free font Print Clearly. It closely resembles the alphabet that elementary students learn to write with. Repeat these steps until your page is filled with letters!
I went a little overboard and made another whole sheet of letters.
8. Print your monster and letters. Using your precision scissors cut out your monster. Also cut out his mouth with your exacto knife. Use your 1.5″ circle punch to punch out your letters.
9. Apply foam adhesive to the front of your milk carton. Take your full body monster, line him up with the monster below, and adhere him. Trim his feet and excess belly off so that he ends where the milk carton ends.
10. Using your foam brush apply a VERY THIN layer of modge podge to the back of one of your letter circles. Adhere this to a wood nickle. When using modge podge for a project like this, a little goes a long way. In the picture below you can see that my paper has slightly curled from applying the modge podge. That is okay! What you don't want is for your paper to become wrinkled from applying too much modge podge. Repeat this step until all letters are adhered.
11. Your project is finished! Pick a letter for your kiddo to "feed" the monster. For example I would set out all my wood nickles that had the letter A on them. Some would be upper case (A), and some would be lower case (a). I would show my daughter an uppercase A and have her "feed" the monster all the uppercase A's.
This is just one fun alphabet game you could play with your kiddo and the "Feed the Monster." While I was making this tutorial I also created word strips for my daughter to use the wood nickles with. After "spelling" a word she then gets to "Feed the Monster" her letters.
If you want to help your kiddo with math you could also make number wood nickles. The possibilities using the "Feed the Monster" are endless! If you make a "Feed the Monster" or any other type of preschool activity with Kate's doodles be sure and share a link in the comments so we can see them!


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Advice to Bride's on How to Choose the Right Photographer
Choosing the right professional for your photography needs can be a very daunting task. There are so many out there and you never know what your pictures will be like until they are already taken and given to you. This can be a scary ordeal to consider. Everyone wants their wedding pictures to be perfect. So how do you get the right photographer for you? Well there are no guarantees unfortunately, but here are some ways to help get you on the right track!
1. What Do You Want From Your Photographer? This is a simple yet complex answer that you NEED to think of before you even start searching for a photographer. KNOW WHAT YOU WANT. Knowing the style, price range, date and hours needed, required shots, package requirements, type of attire you'd like them to wear, personality (this is very important), and any other details that you can come up with, all will help you in the long run. With this information, you can narrow down the thousands of photographers out there and come up with a nice list that you know can deliver what you're looking for.
2. Meet, Greet, and Ask Questions. Setting up an appointment and meeting with your potential photographers is a very important step. Meeting them in person can give you a good indication on whether or not they are compatible with what you are looking for. Meeting them enables you to see what their personality is like, gives you a chance to ask questions, allows you to discuss more in detail about your requirements and options for your package, and also can give you a chance to get your hands on one of their portfolios to look at. You never know what a person is like until you meet them, so it is always a great chance to see what you're up against. While you're there, also make sure that you ask a lot of questions. The more the better!
3. Portfolio and Experience Level. These two are probably the two key elements when choosing a photographer. When you meet with them, make SURE you take a look at their portfolios (click here to see mine). Looking online is one thing, but looking at more of their work in albums allows you to ensure quality. With the portfolio, it gives you an idea of their experience level, but you also want to ask them about it. Ask how many weddings they've done, how many years of experience they've had, what their training has been? Never be afraid to ask too many questions. You are hiring them and you need to make sure that they are a seasoned photographer that can deliver the pictures you are looking for.
Always keep these top three in mind when you are looking for a photographer – especially for your wedding! With these at the forefront of your thoughts, you can have much more success in finding the perfect photographer! All the best and happy hunting!
p.s. All the photos that you see on this blog post are submitted to WPPI 16″x20″ annual print competition. I posted here so you guys can add me on your prayer list! And also, I want you guys, my lovely faithful reader, to be part of my journey too! Wish me luck! 😉


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Osha - the Herb, Not the Acronym - for Chronic Fatigue Syndrome
When I hear of OSHA, I normally think of a government agency (The Occupational Safety and Health Administration). Osha is also an herb, which is used to fight colds and viruses. It has anti-viral and anti-bacterial properties. It is said to be especially good for upper respiratory infections, and it helps oxygenate the blood.
I had never heard of Osha until the other day, however. I had just moved across three states and was run down and experiencing some symptoms of chronic fatigue syndrome. It could have been a cold, or even allergies, but I was just bone tired and feeling like a truck hit me. Even though I do holistic healing, I forget sometimes to take care of myself using the tools available. I remembered there was a health food store across the street from my new apartment complex, and I went there to get some natural remedies.
On seeing the row of herbal supplements, I was a bit overwhelmed. None of them had any identifying info on what they might help with (thanks to an overzealous FDA). I muscle tested and picked out that Osha would be good for me. I had no clue what it was for, so I asked a clerk who brought back a huge book of herbs. When he told me Osha was a strong anti-viral, I knew my muscle testing had done a good job.
Upon taking one dosage, I started feeling more energized and back to my old self. I am additionally taking Emergen-C Immune Support.
With the quick response my body had to the Osha, I have to wonder if Osha is not a potentially good herb to use for chronic fatigue relapses. An Internet search did not come up with much, however. It may be, though, that Osha helps with chronic fatigue due to its anti-viral properties. Researchers are still looking at a causal link between CFS and viruses. One theory is that in CFS patients, a normally mild virus may have crossed the blood-brain barrier, causing CFS symptoms.
So if you are experiencing a CFS relapse, you may want to give Osha a try. It can be found at health food stores and on the Internet.
More herbal remedies for chronic fatigue syndrome: http://www.herbcompanion.com/health/Chronic-fatigue-syndrome.aspx
PS Emergen-C is offering free samples for a limited time here: http://www.emergenc.com/free-samples
Thu, 08/04/2011 - 2:53am
I thought I would leave my first comment. I don't know what to say except that I have enjoyed reading. Nice blog. I will keep visiting this blog very often.I had found this blog before. The advices in this post are very helpful and I surely will read the other posts of this series too. Thank you for posting this. I admire the time and effort you put into your blog and detailed information you offer! I didn't know that! icnd | 642-832 | 640-553 | 642-982 | 650-177 | 642-974 | 642-062 |


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[To celebrate my first year of programming I will ask a 'stupid' questions daily on my blog for a year, to make sure I learn at least 365 new things during my second year as a developer]
Oki, English is not my first language so I tend to look up English words a lot, just to make sure that I know what the word means. Immutable and mutable are words often used in OO programming, and I needed a good definition and examples as I was trying to explain this to a friend. Oki, the picture examples below are not perfect, but I couldn't think of anything better. If you have a great example, please share! I'll update the post and add new images 🙂
Immutable: The state of the object cannot be changed after creation
Example: String , you can't change it after it is created. It looks like you can, but what happens is that a new string is created.
Mutable: The state of the object can be changed after creation
Example: Stringbuilder , you can change this object after you have created it. You can append, remove, replace, or insert characters to the same object,- a new one isn't created as with String.
13 Responses to "'Stupid' Question 30: What do we mean by immutable and mutable in OO?"
I think you have your tattoo metaphor backwards. If the tattoo is finished, it's immutable. The drawing, since it can be erased and edited in place, is mutable.
Yup she dun it backwards, wot a blondy 😛
immutable = unchangeable
mutable = can change and i know cos i was just watching pluralsight videos 🙂
You might also be interested in looking at persistent data structures[1].
A tattoo is a good analogy for an immutable type but is also works well for persistent data structures.
Any part of the tattoo that is drawn is immutable and cannot be changed but new tattoos can be built on top of it (eg. filling in the colour). The old tattoo, the outline, then exists both as a tattoo on it's own and as part of a newer, bigger tattoo.
Maybe that analogy is a little shaky, the linked list example in the wikipedia article makes things much clearer.
nice way of presenting the concept…
So… we know the difference. But what makes knowing this difference powerful to us as a developer?
Large immutable objects "may" be a potential source of performance issues if they have to change regularly, but with modern PCs being so powerful would we ever see an issue? Would we have more reason to worry about this in the server space where there may be many more instances to consider?
It also helps to think that the word stems from mutate/mutation. If the characters of X-men were " immutants", they would have a problem 🙂
[…] 'Stupid' Question 30: What do we mean by immutable and mutable in OO? and Free 'book' : User Experience Guidelines for Metro/Windows 8 style apps (WinRT apps) and 'Stupid' Question 31: What's the deal with String and string in C#? (Iris Classon) […]


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Last year our family was introduced to The Brinkman Adventures and thoroughly enjoyed Season 2. When I learned that The Brinkman Adventures Season 3 was available for review, I knew that my children would be thrilled. Who doesn't love a good audio drama?
The Brinkman Adventures is a radio drama that shares stories about the Brinkmans, a large fun-loving family. Along with the adventures of the family, true stories of modern day missionaries and Christian heroes are shared as well. The dramatization of these stories is very well done. You will find yourself laughing at the antics of the Brinkman children and then on the edge of your seat as ordinary people are being used in extraordinary ways by the Lord.
There are twelve episodes (Episodes 25 – 36) included in The Brinkman Adventures: Season 3. Season 3 takes us on exciting new adventures: Bible smuggling, "killer" bees, Taliban jail, and more.
When Brinkman Adventures: Season Three arrived, I do not believe I even held it in my hands for more than a minute. My children were eager to pop the CD in and begin listening. Within the first few days, my oldest daughter had listened to the complete season. It appears that the Brinkman Adventures is perfect for when you have a few knitting projects to wrap up.
"It's nice. I really like when they go into different places, different countries. I like hearing the different languages. The way people sound different." Sarah – 7
In the afternoons or evenings, my children all grabbed activities, found comfy spots in the living room, and listened to Season 3 for an hour or two. It is a beautiful sight for this mom! Drawing, knitting, clay work, and Legos are all in action while my children are learning amazing stories about people serving the Lord faithfully.
"It's fun to listen to. I liked Season 2 better but this one was good. My favorite was the story about the pocket monkey that gets out on the plane. It was funny. " Hannah – 9
Sharing the love of Christ and God's word is so important. Helping our children to see how anyone can serve faithfully no matter the circumstances, seeing how God provides in amazing ways, and how needed the Gospel is around the world is foundational to the future. The Brinkman Adventures is a great tool for this purpose. After listening to the episodes, you can visit Real Stories at The Brinkman Adventures website to learn more about the inspiration for the stories shared.
"I really like it. It is a normal family that has every day problems. The missionary stories are really interesting. Steve Saint played himself and I think that is neat to get real people to tell their story." Lydia – 12
The Brinkman Adventures is perfect entertainment for the whole family. Road trip coming up? Grab a season or two for the road! These radio dramas would also be great for a family gift this holiday season. You could easily incorporate these into your "morning/circle time" or Bible study. The episodes are about 30 minutes so easy to listen to an episode and have some discussion. If your church has a missions program for children, the Brinkman Adventures could be another valuable resource to have on hand.
"I enjoyed Brinkman Adventures because I love hearing missionary stories. Their faith is encouraging and thought provoking. I like listening to the Brinkman's because they are a lot like us; nine kids and happily chaotic. My favorite this season was a Saint's Story." Rebekah – 16
You can also listen to an episode of The Brinkman Adventures online. Currently, Episode 9: The Provider is available. The three season are available in CD and MP3 format.


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pair of 19th century giltwood and gesso girandole mirrors Read more
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