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Background Preclinical in vivo research using small pets are considered essential in translational cancer research and scientific implementation of novel treatments. purpose, research completed with different tumor histotypes had been considered inside our evaluation including breast, digestive tract, lung, fibrosarcoma, pancreas, mind and melanoma and throat cancers. For all your tumors, buy Dabigatran etexilate mesylate the / proportion was assumed to become 10 Gy, as adopted for neoplastic cells generally. Results Our outcomes support the hypothesis the fact that occurrence buy Dabigatran etexilate mesylate price of abscopal results in preclinical versions boosts with BED. Specifically, the likelihood of uncovering abscopal results is certainly 50% whenever a BED of 60 Gy is certainly generated. Bottom line Our research provides proof that SABR remedies connected with high Bedrooms could be regarded an effective technique in triggering the abscopal impact, losing light in the guaranteeing buy Dabigatran etexilate mesylate outcomes uncovered in clinical practice thus. Launch About 50C60% of solid tumors are treated with radiotherapy (RT) by itself or in conjunction with medical procedures and/or various other therapies such as for example chemotherapy, immunotherapy, hyperthermia to improve overall survival in comparison to single-modality therapy. Different RT remedies adopted in scientific practice try to treat the condition sparing normal tissues from extreme toxicity. Appropriately, toxicity surrounding regular tissue along with other factors, such as for example poor blood circulation and hypoxia are generally recognized to limit the achievement of traditional RT of cumbersome or deep-seated tumors. Intra-Operative RT (IORT), or the Stereotactic Ablative RT (SABR), using high dosages in a few or one fractions, named oligofractions, have become an attractive healing substitute for improve cancer individual result [1,2]. Actually, technological advancements with regards to dosage delivery and accurate set up of linear accelerators given imaging devices enable more conformal dosage delivery also at high dosage rates. It has additional encouraged rays oncologists to look at schedules of serious remedies with dosages per fraction greater than 10 Gy or more to 20C30 Gy. From a radiobiological perspective, versions and dosage constrains followed for regular fractionation are under controversy with regards to appropriateness and robustness presently, rousing analysts toward performing confirmatory pre-clinical and clinical research consequently. Importantly, research from many laboratories are recommending that RT with high dosage per small fraction (>8-10Gcon) might cause additional indirect natural results besides buy Dabigatran etexilate mesylate the immediate RT tumor cell eliminating. These indirect natural results, referred to as abscopal and/or bystander results [3 primarily, 4, 5] are recognized to involve anti-tumor immunity today, and/or vascular harm and/or various other immunogenic types of tumor cell loss of life from the activation of indicators resulting in apoptosis, necroptosis or necrosis [6, 7]. Furthermore, predicated on the linear quadratic (LQ) model, locoregional and faraway tumor control by SABR or stereotactic radiosurgery [8] is certainly underestimated in comparison with scientific results. Oddly enough, this discrepancy may very well be because of failing to look at the significant contribution from the indirect natural results [9, 10, 11]. Lately, the abscopal impact (AE) continues to be sporadically seen in scientific cases (evaluated in [12, 13,14]) aswell as reported in and preclinical research [4, 5]. We think that with current contemporary technologies, which permit the delivery of higher dosage per small fraction to tumors (such as for example in SABR treatment), the traditional radiobiological versions useful for data result and explanation predictions could become outdated or buy Dabigatran etexilate mesylate regardless limited, excluding the activation from the tumor microenvironment. This hypothesis is not fully is and explored intriguing for the outcome of modern RT treatments. Indeed, AE could possibly be beneficial in high-risk tumor patients where healing failure is principally due to faraway disease progression rather than to regional recurrence. Accordingly, outcomes from our previously research have confirmed that high RT dosage (20 Gy) tumor delivery must cause AE in preclinical mouse versions [15]. Of take note, our research centered on the function from the biologically effective dosages (BED) that is clearly a parameter linked to the anticipated survival utilized to evaluate and estimation the efficiency of different RT schedules [16]. Since 1989, BED continues to be introduced to evaluate the consequences of different fractionations in radiotherapy with regards to cell eliminating Mouse monoclonal to CD4.CD4 is a co-receptor involved in immune response (co-receptor activity in binding to MHC class II molecules) and HIV infection (CD4 is primary receptor for HIV-1 surface glycoprotein gp120). CD4 regulates T-cell activation, T/B-cell adhesion, T-cell diferentiation, T-cell selection and signal transduction [17]. By description, BED is certainly higher when the dosage per fraction boosts using the same total dosage i.e. when schedules are far better biologically. Certainly, our experimental outcomes [15] suggestively indicated that planned treatment and the full total radiation dosage may be essential determinants of AE. In today's study, with the purpose of determining the lifetime of a feasible BED cut-off, with the capacity of triggering AE, we evaluated one of the most relevant research involving animal versions and reanalyzed the reported data from a radiobiological viewpoint. In this respect, we evaluated if the plan, the delivery modality (RT program, irradiation source,.
Question: How can health sciences librarians and biomedical informaticians present relevant support to Clinical and Translational Technology Award (CTSA) staff? Setting: The Spencer S. and quality of translational study and provides funding specifically to motivate experts to collaborate across disciplines for the good of human health. To provide relevant support to CTSA staff and biomedical experts at the University or college of Utah (U of UT), faculty of the Spencer S. Eccles Health Sciences Library and the associate vice chief executive for information technology for the health sciences office (AVP ITHS) carried out an extensive needs assessment having a producing directive white paper. The following case study explains the process used to strategy both a virtual Internet portal as well as a physical collaborative space for the U of UT and three inter-institutional CTSA partners. U of UT's model and encounter can assist additional librarians and informaticians with how to become portion of a CTSA-focused infrastructure for medical and translational study and serve their experts in general. 16562-13-3 manufacture THE University or college OF UTAH'S CLINICAL 16562-13-3 manufacture AND TRANSLATIONAL Technology Honor The U of UT's Center for Clinical and Translational Technology (CCTS) received its CTSA in 2008. The CCTS is definitely a close-knit medical community that includes fundamental and medical experts, strong genetics and biomedical informatics departments, and a wealth of genealogical info in the Utah Populace Database (UPDB). The CTSA includes three additional partner organizations: the Division of Veterans Affairs (VA) Salt Lake City Health Care System, 16562-13-3 manufacture Intermountain Healthcare, and the Utah Division of Health. The CTSA give proposal envisioned a statewide web portal that would act as an access point for experts, clinicians, community companies, patients, and additional CTSAs to discover information about CTSA programs and opportunities, institutional resources, and each other. The portal would be the electronic entrz to the Federated Utah Study and Translational Health eRepository (FURTHeR) and additional research resources supported by core facilities. FURTHeR is definitely a standardized query engine for accessing the rich medical, research, and general public health data from your U of UT and its partner institutions. The web portal, which would collect info already available to experts, Mouse monoclonal to CD81.COB81 reacts with the CD81, a target for anti-proliferative antigen (TAPA-1) with 26 kDa MW, which ia a member of the TM4SF tetraspanin family. CD81 is broadly expressed on hemapoietic cells and enothelial and epithelial cells, but absent from erythrocytes and platelets as well as neutrophils. CD81 play role as a member of CD19/CD21/Leu-13 signal transdiction complex. It also is reported that anti-TAPA-1 induce protein tyrosine phosphorylation that is prevented by increased intercellular thiol levels would also link to additional research resources supported from the U of UT, including related staff. The portal would be called My Study Assistant (MyRA). Though the collaborative portal was not funded, the AVP ITHS did not lose sight of the need for any portal. She met with the director of the Eccles Library, and they put together a committee that would determine researcher needs and content for any portal (the MyRA Committee). This inter-institutional committee, cochaired from the Eccles Library director and a biomedical informatics professor, met frequently for two years to discuss its collective vision for MyRA and determine important and relevant content material as well as targeted audiences. Other members 16562-13-3 manufacture of the MyRA Committee included a CTSA community engagement core codirector, an academic librarian, associates from Intermountain Healthcare (librarian and study office administrator), an informatician having a joint visit with the VA hospital, a CCTS data analyst, informatics software technicians, and a MyRA specialist. Through AVP ITHS office funding, a contractor, Margaret Reich Consulting, was hired to conduct a needs assessment to determine what experts would find useful or desired and to inventory what products and resources (especially social networking tools) MyRA could offer. All of these findings were consolidated into a recommendation white paper to assist in MyRA's development. The MyRA mission and vision statements can be found in Number 1. Number 1 MyRA mission and vision statements A librarian carried out a literature review to determine if any web portals much like MyRA had been developed and how the needs for such portals were assessed. PRIMER and StarBRITE are two such portals, built for the research areas at Duke University or college 1 and Vanderbilt University or college 2, respectively. Both portals are similar.
Gamma oscillations of the local field potential are organized by collective dynamics of numerous neurons and have many functional roles in cognition and/or attention. The sensitivity of rising and decaying time constants is analysed in the oscillatory parameter regions; we find that these 168273-06-1 sensitivities are not largely dependent on rate of synaptic coupling but, rather, on current and noise intensity. Analyses of shunting inhibition reveal that it can affect both promotion and elimination of gamma oscillations. When the macroscopic oscillation is far from the bifurcation, shunting promotes the gamma oscillations and the PRF becomes flatter as the reversal potential of the synapse increases, indicating the insensitivity of gamma oscillations to perturbations. By contrast, when the macroscopic oscillation is near the bifurcation, shunting eliminates gamma oscillations and a stable firing state appears. More interestingly, under appropriate balance of parameters, two branches of bifurcation are found in our analysis of the FPE. In this case, shunting inhibition can effect both promotion and elimination of the gamma oscillation depending only on the reversal potential. = 1000 inhibitory neurons as described by the quadratic integrate-and-fire (QIF) model. The QIF model is a representative model of Class I neurons and is widely used for computational studies [22C24]. Here, represents stochastic fluctuations with and is the magnitude of the fluctuation, = 1 F cm?2 is the membrane capacitance and (A cm?2) is a constant current. where it will then tend towards that satisfies the relation 2.4 Then, equation (2.1) reads as 2.5 We call this the modified theta model because it is a physiologically precise version of the theta model, which is well known as a reduced model of Class I neurons [15]. It should be noted that the conversion to the modified phase model is valid even under strong noise or synaptic interactions because it is not derived from a phase reduction, which 168273-06-1 is valid only in the case of weak interactions [11,29,30], but rather by the transformation of variables. 2.1.1. FokkerCPlanck equation and macroscopic phase reduction by the adjoint method We developed an 168273-06-1 appropriate adjoint method for the population of the neurons, each of which is described by the modified theta model (equations (2.3) and (2.5)). First, we set the current = 2, noise intensity = 2 and probability of connections and = 0.2 1000 = 200 FASLG and = [18,33], it satisfies = (and < = 0 is set so that = 0) is the maximum firing probability. as = with = (are 2.11 2.12 These equations can be rewritten in matrix 168273-06-1 representation as 2.13 where 2.14 2.15 2.16 2.17 The phase space of equation (2.13), is the sensitivity of a single neuron to the phase [20]. This equation provides unique insights into how the external perturbations and/or changes of internal states affect macroscopic properties of gamma oscillations and will be discussed in following 168273-06-1 sections. 3.?Results In order to study the dynamics of large networks of neurons with synaptic coupling, we have extended the so-called theta model (a continuous version of the QIF) to incorporate conductance-based synapses. We did this in order to explore how aspects of synaptic coupling, for example shunting inhibition, affect the ability of inhibitory networks to produce population rhythms. The advantages of the theta model over other simple spiking models are that the model is continuous and certain numerical computations are much easier. For large numbers of neurons with random coupling, we can reduce the system to a single PDE for the firing rate and synaptic activity (see Material and methods). We can thus turn the focus onto the dynamics of a deterministic system for which there are many available tools. 3.1. Population dynamics of the modified theta models The numerical computation results for the population of the modified theta models (equations (2.3) and (2.5)) with nominal values of parameters are shown in figure 1shows an example of the membrane potential of a single neuron, which is obtained by reversal transform of equation (2.4). We can see that in this parameter set, there is sparse firing in which the individual neurons do not fire at every gamma cycle. We also confirmed that the numerical simulation of the corresponding FPE (equations (2.6) and (2.7)) accurately matches the simulated population dynamics (figure 1with and shows the two-parameter curve for noise amplitudes, = 1, 2. Below the curve (small inputs and sparse connectivity), the constant asynchronous state is stable and above it, there will be oscillations in = 1. HB, Hopf bifurcation. (shows a two-dimensional solution of the adjoint method,.
Background Post-translational phosphorylation is among the many common protein modifications. bioinformatics The reversible phosphorylation of serine Background, threonine and tyrosine residues by enzymes from the kinase and phosphatase superfamilies may be the most abundant post translational adjustment in intracellular proteins [1,2] and can be an essential system for modulating (regulating) many mobile processes such as for example proliferation, apoptosis and differentiation. Eukaryotic proteins kinases form among the largest multigene households, and the entire sequencing from the individual genome provides allowed the id of virtually all individual proteins kinases, representing about 1.7% of most human genes [3]. The function of a person proteins kinase in a specific cellular process, nevertheless, will be completely explained only once the foundation for kinase substrate specificity will be better understood. Identifying the substrate specificity of protein kinases is among the key issues in molecular biology even now. Phosphorylation site predictors like the CBS predictor NetPhos [4] predicated on artificial neural systems [5,6], or Scansite [7] predicated on peptide collection derived position-specific credit scoring matrices (PSSM) [8] possess gone a way to enabling molecular biologists to recognize potential kinase substrate sites in query protein, but suffer to a qualification from over-prediction. The ELM reference attempts to lessen such complications using contextual filtering of motifs predicated on framework, cell area, taxonomic limitations, and various other properties of proteins [9]. Because of the biological need for proteins kinases in cell signaling as well as the progressively growing level of reviews determining phosphorylation sites [10] it is becoming impractical for experimental molecular biologists to keep an eye on all of the phosphorylation adjustments of protein of their area of analysis. Furthermore, large-scale program and proteomic biology methods to cell regulation cannot succeed without complete usage of phosphorylation data. There is as a result a have to create and keep maintaining a comprehensive data source of known, confirmed phosphorylation sites within proteins experimentally. We describe right here Phospho.ELM [11], a server interfaced to a manually curated data source of phosphorylation sites (instances) that delivers quick access to details from the principal technological literature concerning experimentally verified serine, threonine and tyrosine phosphorylation sites in eukaryotic protein. Content and Construction Phospho. ELM is deployed and developed with open up supply software program. The database administration system used is normally PostgreSQL [12]. The program originated in Python 2.2 including some modules in the BioPython.org task for retrieval of details from SWISS-PROT as well as the PyGreSQL module for PostgreSQL interfacing. The net interface software program uses the CGI model construction [13]. The Phospho.ELM 1.0 database included 74681-68-8 IC50 a dataset of 289 proteins. The existing discharge (Phospho.ELM 2.0) provides integrated data from PhosphoBase to provide a complete of 556 protein (299 individual, 52 mouse, 54 rat, and 151 from various other types). The Phospho.ELM dataset represents the biggest assortment of experimentally verified phosphorylation sites: the annotated protein contain 556 tyrosine, 913 serine and 234 threonine phosphorylation sites (situations) that are verified Rabbit polyclonal to CD47 substrates for 119 different proteins kinases (Desk ?(Desk11). Desk 1 Selected proteins kinases, their course, the true variety of known protein substrates as well as the instances recorded in Phospho.ELM. In the Phospho.ELM data source information is presented in two classes, phosphoprotein and instance. The key 74681-68-8 IC50 details includes the phosphorylated site 74681-68-8 IC50 (example) and its own flanking series within a proteins, that experimental evidence continues to be within the literature. Furthermore, annotations to each example consist of (where known) the kinase(s) that phosphorylate(s) the provided site, the domains(s) that bind to a phosphorylated.
Background Saturated brines are intense environments of low diversity. organic focuses on for phage predation [37,38]. We hypothesise that cell wall structure polysaccharide variability given by metagenomic islands could are likely involved in defence from this predation. Before, phages have already been proven to focus on lipopolysaccharide through their sponsor reputation machineries strain-specific or [39] polysaccharases [24]. In the precise case of S. ruber, many the different parts of MGI 1 and MGI 2 indicate this sort of technique particularly. They consist of genes involved with biosynthesis of colanic acidity, been shown to be hydrolysed by phage induced enzymes in Escherichia coli [24], and sialic acidity biosynthesis genes, reported to be always a correct section of phage receptors [39]. In densely filled aquatic habitats such genes will become at the mercy of arm races (also called Crimson Queen strategies), and become required to become as plastic material as their bacteriophage counterparts to keep up an acceptable population density and prevent catastrophic accidents of the populace because of phage lysis. This hypothesis can be supported by outcomes showing high manifestation of metagenomic isle genes recommending that they encode protein central to mobile processes in particular genotypes [13]. To be able to attain the desired degree of genome plasticity as least two systems could be used. Metagenomic islands are transposase wealthy areas where genes often talk about homology with multiple phylogenetically varied microbes and therefore might become lateral gene transfer popular spots to 81846-19-7 be able to attain the observed degree of genome plasticity. Extra diversification through lateral gene transfer and recombination could possibly be accomplished through modular company of cell wall structure polysaccharide biosynthesis genes. This is seen in genome of S. ruber where a lineage-specific group of genes, located inside the metagenomic isle, can be preceded by rfb gene cluster involved with rhamnose biosynthesis and additional upstream by mur and fts clusters involved with peptidoglycan synthesis. This trend has been mentioned in at least each other varieties. In Streptococcus thermophilus, a Gram positive 81846-19-7 varieties and without lipopolysaccharide consequently, the exocellular polysaccharide biosynthesis cluster comprises primary gene cluster, displayed by deoD-epsABCD, and accompanied by a adjustable region [40]. Oddly enough, just like crystallizer brine, the environment of Streptococcus thermophilus also helps dense microbial areas with low microbial variety that is without protists grazing. Summary Tiling the genomic series of S. ruber DSM 13855 against reads through the NORTH PARK saltern crystallizer metagenome shows how the conserved backbone of the genome can be well displayed in the metagenomic data. This total result is fairly remarkable because this isolate originates from a Mediterranean solar saltern. However, like additional microbial genomes in comparison with a metagenome where they may be well-represented the tiling from the genome leaves bare parts of low insurance coverage or metagenomic islands. Metagenomic islands talk about many features with traditional genomic islands referred to by evaluating genomes of carefully related strains such as 81846-19-7 for example atypical GC content material, high rate of recurrence of phage/Can be components and hypothetical genes. Nevertheless, their gene content appears involved with biosynthesis of cell wall polysaccharides largely. This phenomenon is apparently general with this and additional marine microbes researched and might reveal a PAPA1 global technique of bacteria to flee phage predation [14]. Strategies Genomic libraries and sequencing Environmentally friendly 81846-19-7 genomic sequences gathered from Santa Pola solar salterns (Alicante, Spain) had been obtained inside a earlier study as referred to in [11]. The DNA was extracted from biomass maintained on the 2 m pore size filtration system. A 2000 clone fosmid collection was end sequenced leading to 81846-19-7 2947 obtainable sequences. Environmentally friendly genomic sequences gathered from Chula Vista solar salterns (Chula Vista, CA), had been from biomass maintained on the 0.2.
Assessments of generative semantic verbal fluency are widely used to study business and representation of concepts in the human brain. in a sample consisting of healthy participants and those differentially affected by cognitive impairment. We found that semantic clustering indices were associated with brain network connectivity in distinct areas including fronto-temporal, fronto-parietal and fusiform gyrus regions. This study shows that computerized semantic indices complement traditional assessments of verbal fluency to provide a more complete account of the relationship between brain and verbal behavior involved business and retrieval of lexical information from memory. (1997) relies on manual categorization of words produced around the SVF test (e.g., Zoological Categories, Human Use, and Living Environment) with further more fine-grained subcategorizations (e.g. living environment category composed of African, Australian, Arctic/Far North, Farm, North American and Water Animals). In addition to their subjectivity, these manual qualitative approaches are time consuming and are difficult to implement and standardize, which may be responsible for some of the conflicting results obtained with these methods in studies of Alzheimers disease noted in previous work (Raoux et al., 2008). Independently of these efforts, a number of fully automated approaches to representing the degree to which any two words in 19916-73-5 supplier a given language are semantically related have been developed in the field of computational linguistics based on lexical databases such as WordNet, as well as corpora of text (Pedersen, Pakhomov, Patwardhan, & Chute, 2007; Rada et al., 1989; P. 19916-73-5 supplier Resnik, 1999). Many of these approaches utilize variations on a technique called Latent Semantic Analysis (LSA: (Landauer & Dumais, 1997)), a variant of factor analysis designed for representing lexical semantics. In addition to the LSA approach to semantic representation, several other alternatives have been proposed to model how semantic information is represented in the brain including neural networks (McClelland & Rogers, 2003), Random Indexing (Kanerva, 2009), Latent Dirichlet Allocation (LDA) modeling (Blei, Griffiths, Jordan, & Lafferty, 2003), and distributional E.coli polyclonal to GST Tag.Posi Tag is a 45 kDa recombinant protein expressed in E.coli. It contains five different Tags as shown in the figure. It is bacterial lysate supplied in reducing SDS-PAGE loading buffer. It is intended for use as a positive control in western blot experiments memory models (Baroni & Lenci, 2010; Baroni, Murphy, Barbu, & Poesio, 2010). The application of LSA to semantic representation is usually described in detail in the Methods section. In brief, LSA relies on the co-occurrence of words in a large corpus of text consisting of various types of discourse including newspaper articles, books, speeches and other sources of common word usage to represent the semantic content of a word or a term as a set of co-occurrence counts with other words used in the same context. These semantic representations can then be directly and automatically compared to each other to assign a numeric value indicative of the strength of semantic relatedness between them. Apart from improved scalability and objectivity as a result of automation, these computational approaches allow quantification of semantic relations on a continuous rather than a 19916-73-5 supplier categorical scale which allows us to: a) directly control and systematically vary how measures such as the cluster size, for example, are calculated, and b) develop new semantic indices not possible with categorical judgments. We have previously reported on applications of these computerized semantic indices, either calculated from WordNet, a large lexical database (Pakhomov, Hemmy, & Lim, 2012), or from a a corpus of text (Pakhomov & Hemmy, 2013). In other prior work, computational models of word meanings derived from a very large corpus of text have been demonstrated to predict neural activation patterns observed with fMRI (Mitchell et al., 2008). These findings were based on representations for concrete nouns and thus provide a strong motivation for using distributional semantic approaches to represent the meaning of words produced in response to a verbal fluency task. The mechanisms underlying memory are negatively affected by aging (Meinzer et al., 2009) and are the target of several types of neurodegenerative diseases including the semantic variant of fronto-temporal dementia (Grossman, 2002; Hodges et al., 2004; Knopman et al., 2008) and the Alzheimers disease (AD) dementia (Hodges & Patterson, 1995). In our previous work, we found that computerized semantic indices were sensitive to clinical differences between moderate cognitive impairment (MCI) and AD dementia (Pakhomov et al., 2012), and could be used to estimate future risk of 19916-73-5 supplier developing dementia in healthy individuals (Pakhomov & Hemmy, 2013). The current study relies on a sample consisting of cognitively normal individuals as well as MCI and AD dementia patients in order to investigate the relationship between SVF performance.
Age-related macular degeneration (AMD) is a common disease that can result in severe visual impairment. risk of AMD by approximately twofold to sevenfold, depending on the population studied.5C8 This variant results in the substitution of histidine for tyrosine at amino acid residue 402. The effect of this polymorphism in the human eye is not well understood, although adults harboring the Y402H polymorphism show increased choroidal C-reactive protein9 and increased membrane attack complex (MAC).10 Formation of the MAC is the final event in the terminal portion of the complement cascade and results from the binding of C5b to plasma complement proteins C6, C7, C8, and multiple molecules of C9. MAC forms transmembrane channels that lead to cell lysis and death. The MAC has been found in drusen of older eyes with AMD.11 However, the relative abundance and distribution of MAC in aging, early AMD, and advanced AMD have not been comprehensively studied. Inhibition of MAC components such as C6 can inhibit CNV,12 and other complement pathway inhibitors are in active clinical trials for the treatment of AMD.13 Because it is the ultimate downstream effector of the complement pathway, understanding the role of the MAC in the pathophysiology of AMD is important for the development of new therapies. We evaluated the MAC in a large series of donor eyes. MAC was present in Bruchs membrane and choriocapillaris in very young eyes, but the concentration increased with age; we observed the highest levels in eyes with AMD. We further evaluated the MAC in a series of eyes from young and old donors, and from donors with early and advanced AMD. Although in early AMD the MAC is associated exclusively with the choriocapillaris, in advanced AMD the RPE may be exposed as well. Morphometric experiments suggest that high-risk genotypes may contribute to thinning or atrophy of the choroid. Overall, these studies suggest that choroidal endothelial cells are targets of the MAC and that approaches to prevent their injury from complement-mediated lysis may be useful in the treatment of AMD. Materials and Methods Human Donor Eyes Whole globes from human donors were obtained from the Iowa Lions Eye Bank (Iowa City, IA). Full consent for research was obtained from the donors next 548-83-4 manufacture of kin in all cases, and all experiments were performed in accordance with the Declaration of Helsinki. Eyes were processed within ID1 9.5 hours of death (range, 1 548-83-4 manufacture hour 42 minutes to 9 hours 15 minutes). For biochemical studies, a 6-mm juxtamacular, inferotemporal punch was acquired. Neural retina 548-83-4 manufacture and RPECchoroid layers were collected separately and snap-frozen in liquid nitrogen, before long-term storage at ?80C. Macular punches and/or superotemporal wedges were collected from each eye and preserved in 4% paraformaldehyde in phosphate-buffered saline within 8 hours of death. After 2 hours of fixation, eyes were washed in phosphate-buffered saline and then were cryoprotected in sucrose and embedded in?sucroseCoptimal cutting temperature medium, as described by Barthel and Raymond.14 Quantification of Soluble C5b-9/MAC Samples were chosen 548-83-4 manufacture for MAC quantification from a collection of frozen juxtamacular punches of RPECchoroid, centered approximately 7 mm temporal to the fovea. Ten RPECchoroid samples were selected from each of three groups: young (mean age, 39.6 years; range, 21.


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You will remember that I failed from my self-imposed challenge of coming up with 52 Game Ideas within a year. However, my decision was to keep going and add new ideas to the list as they come. After a quite long break, here is finally a new game idea. Enjoy!
Game Idea #42
We Built This City (WBTC)
WBTC is a city and road construction set that can be used to create a simulated city environment that can host a variety of games simultaneously.
Sample Mission Brief for a class of up to 30 students:
Form groups of up to six players. Use the WBTC set and any material of your choice to build a city around a certain theme (China, ghosts, lunar city, mafia, film festival etc…). Connect the cities to each other when their design is finished to have a group of city districts, however limit players access to the districts of their friends. Play a racing or exploration game with a reputation system in which for each new level of reputation a player's freedom of travelling expands into a new city district. The player who finishes the quests in all city districts wins the game.
Filed under: Game Concepts, Game Ideas | Tagged: 52 game ideas, Game Concepts | 1 Comment »

subset: commoncrawl


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Talk about a slow burn! The "Catman's kid" storyline introduced way back in Villain's United finally comes to a head in this somewhat disturbing entry into Gail Simone's brilliant Secret Six saga.
Note: I'm skipping #15 (not by Simone), 16 (not by artist Nicola Scott, and only meh), and 17-18 (Blackest Night tie ins). They're nonessential.


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Home / open source
Devon County Council commission futurate to develop regional economic observatory
The Local Democracy, Economic Development and Construction (LDEC) Bill requires all county councils and unitary district councils to prepare an assessment of the economic conditions of their area.
Devon County Council have put the web at the heart of their plans for the development and dissemination of their LEA and Futurate have been commissioned to bring this innovative vision to life.
Wed, 14/04/2010 - 15:42
Futurate to develop new member-focused website for the Association for Learning Technology
The Association for Learning Technology (www.alt.ac.uk) has awarded Futurate the contract to work with the association to develop a new website. The new site will deliver ALT's services, promote ALT's activities (as a professional and scholarly organisation dedicated to spreading good practice in the use and development of learning technology) and facilitate the activities of the main stakeholders.
Wed, 14/04/2010 - 13:01
Edinburgh Zoo: the numbers speak for themselves
Our recent work with on Edinburgh Zoo's website - www.edinburghzoo.org.uk - went live on November 16th 2009 and we are pleased to annouce that there has been a subsequent and significant increase in traffic and revenue. The aim of this project was to:
Fri, 15/01/2010 - 13:53
- News Item
- attractions
- charities
- edinburgh zoo
- online fund raising
- open source
- opencms
- return on investment
- zoos


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Shawn Speakman (Editor) : Unfettered - Limited Signed First Edition - SOLD OUT
Only available to purchasers of the match-numbered copy of "The Dark Thorn"
Leather-bound Signed & Numbered 1st edition/first printing edition that is limited to only 500 copies, signed by all 23 contributors.
Leather-bound Signed & Numbered 1st edition/first printing edition that is limited to only 500 copies, signed by all 23 contributors.
Every story in this volume is new and, as the title suggests, the writers were free to write whatever they wished. Here is the list of contributing authors for Unfettered:
- The Shade of Allanon by Terry Brooks (a Shannara tale)
- Imaginary Friends by Terry Brooks (a precursor to the Word/Void trilogy)
- How Old Holly Came To Be by Patrick Rothfuss (a Four Corners tale)
- River of Souls by Robert Jordan & Brandon Sanderson (a Wheel of Time tale)
- The Old Scale Game by Tad Williams
- Martyr of the Roses by Jacqueline Carey (a precursor to the Kushiel series)
- Dogs by Daniel Abraham
- Mudboy by Peter V. Brett (a Demon Cycle tale)
- Nocturne by Robert V. S. Redick
- The Sound of Broken Absolutes by Peter Orullian (a Vault of Heaven tale)
- Untitled by Geno & R.A. Salvatore
- Keeper of Memory by Todd Lockwood (a Summer Dragon tale)
- Game of Chance by Carrie Vaughn
- The Lasting Doubts of Joaquin Lopez by Blake Charlton
- The Chapel Perilous by Kevin Hearne (an Iron Druid tale)
- Select Mode by Mark Lawrence (a Broken Empire tale)
- All the Girls Love Michael Stein by David Anthony Durham
- Strange Rain by Jennifer Bosworth (a Struck epilogue tale)
- Unbowed by Eldon Thompson (a Legend of Asahiel tale)
- Untitled by Naomi Novik (a Temeraire tale)
- The Jester by Michael J. Sullivan (a Riyria Chronicles tale)
- The Duel by Lev Grossman (a Magicians tale)
- The Unfettered Knight by Shawn Speakman (an Annwn Cycle tale)


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Udemy – Absolute Guide to Starting a Business Online from Scratch [100% off]
Posted on 21/06/2016 by admin | 0 comments
Course Description
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Business basics
How to make money from:
Internet marketing
Trading domains
Writing Ebay
Affiliate marketing
And finally you'll find some extra help you'll need
Every section will contains:
Introduction 3-5 lectures
Further reading to know what kind of skills is needed to succeed in that industry Resources.
There will also be special section at the end for extra help.
At the end of this course you will be able to:
Do a simple market research.
Do competitive research.
Make money from multiple ways.
Manage your time and stay productive.
Choose how to change and when.
Udemy Coupon Code : https://www.udemy.com/absolute-guide-to-starting-a-business-online-from-scratch/?couponCode=A
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Nexx X70 Core Black MT Motorcycle Helmet 01x7001000
Nexx X70 Core Black MT Helmet Motorcycle Scooter Motorbike Open Face Helmet. A stunning old school style open face helmet, this design has changed very little since first conceived by Nexx. This helmet is EEC approved and legal to be worn on a motorcycle in the UK.
- Hull in X-MATRIX (Multi-axial Glass Fibre, Organic Fibres 3D, Special Fibres in Multi-axial Aramid and Carbon Reinforcements)
- Standard ECE / 22-05, DOT and NBR-7471: 2001
- Cap model available in 2 sizes
- X.Mart Dry fabric lining, anti-allergic and anti-perspiration
- Adjustable and removable lining
- Washable interior
- Sunglasses with easy opening mechanism
- Indoor sunglasses, solar 80%
- Micro-metric Lock
- Weight: 990grs


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Foreign cash for U.S. jobs
July 29, 2009
Interesting visa program I didn't know existed:
A bipartisan group of senators is pushing to save the EB-5 visa program, scheduled to expire at the end of September. The program grants temporary visas to foreigners who invest at least $500,000 in distressed areas. If an investment creates at least 10 jobs for American workers, the temporary visa can become a permanent green card. Last year, 945 EB-5 immigrants invested more than $400 million in U.S. ventures.
Some examples
The evolution of the revolution
July 29, 2009
Very interesting acts of civil disobedience people are coming up with in Iran:
The second phase plays out in a boycott of goods advertised on state-controlled television. Just try buying a certain brand of dairy product, an Iranian human-rights activist told me, and the person behind you in line is likely to whisper, "Don't buy that. It's from an advertiser." It includes calls to switch on every electric appliance in the house just before the evening TV news to trip up Tehran's grid. It features quickie "blitz" street demonstrations, lasting just long enough to chant "Death to the dictator!" several times but short enough to evade security forces. It involves identifying paramilitary Basij vigilantes linked to the crackdown and putting marks in green — the opposition color — or pictures of protest victims in front of their homes. It is scribbled antiregime slogans on money. And it is defiant drivers honking horns, flashing headlights and waving V signs at security forces.
The irony of playing the jew card
July 29, 2009
With the recent reports that Netanyahu called Emanuel and Axelrod self-hating jews, I found this at the Economist DIA blog interesting:
Efforts to win support for right-wing Israeli policies are inevitably going to spin off accusations, like Mr Kirchik's, that Jews like Max Blumenthal who criticise Israel are self-hating or in some sense not real Jews. This is a familiar dynamic in ethnic nationalist politics; it's similar to what Slobodan Milosevic did to Serbian liberal opponents, what Putinists do to liberal Russian politicians, or what Mahmoud Ahmadinejad has done to his opponents in Iran. It's actually rather similar, for that matter, to what ethnic nationalists, actual anti-Semites, have always done to the Jews in their countries—claiming they are not "real Russians", "real Englishmen", "real Frenchmen", "real Americans". If those who are slurring liberal Jews critical of right-wing Israeli policies were thoughtful people, this might give them pause. But, for the most part, they're not, and it won't.
via Andrew, who adds:
If you don't agree with Jamie Kirchick, you're a self-hater if you're Jewish and an anti-Semite if you're not.
What a constitutional convention means
July 29, 2009
Good rundown of why it's needed, the logistics, and what needs to be accomplished.
Convenient evidence
July 29, 2009
"Texas Scorched by Worst Drought in 50 Years" reports The Journal, which in no way lends credibility to a global warming theory.
But a snowstorm during a global warming protest? That proves global warming is all made up.
Fair and Balanced (in doublespeak).
Health reform is in this man's hands
July 27, 2009
No, not Obama, not Baucus, not Grassley. It's Doug Elmendorf, CBO director.
Not once, or twice, but three times he has scored Congress proposals' cost way higher than expected, which has resulted on damaging headlines. His rationale is that he is being conservative, and he will not credit any cost savings from changes and programs that aren't proven.
Unfortunately there is little his predecessor Peter Orzag, now Obama's OMB director, can do about it.
Krugman is crying foul, but a lot more pressure needs to be applied.
Misleading layoff news
July 27, 2009
Verizon reported weak Q2 results today due to shrinkage in their wireline unit. So of course they announced more layoffs, which is just standard operating procedure for a CFO wanting to reassure The Street that costs are being contained and profitability is being restored next quarter. Whether those cuts actually materialize no one ever checks.
So you end up with a scary "Verizon to Cut 8,000 More Jobs" headline on the Journal's and other front pages.
Meanwhile we learn that they are aggressively adding FiOS TV and broadband customers, and the rumor is they are hurrying to launch their LTE network in early 2010, perhaps for Apple's tablet, which you would think requires serious capital investments and manpower for deployment. So you have to wonder what the net effect is on jobs. Definitely not 8,000 fewer.
And of course Microsoft is opening dozens of stores, and 7-Eleven is planning a major expansion this year, including 600 stores in Southern California alone. But you would never see this headline on the front pages: "7-Eleven adding 5,000 jobs".


text: The Andale Police Department is warning residents of two possible phone scams. If you receive a call from someone claiming to be from either the IRS or Police/Sheriff's Department, beware. The IRS does not contact citizens by phone. The police and sheriff's departments serve warrants in person and collect fines by mail. If you receive a suspect call, hang up. Never give out personal or financial information over the phone.


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xyzReptiles: Have You Seen the Witblits Bearded Dragon?
On the Web - xyzReptiles discusses the Witblits bearded dragon—a patternless and easy to reproduce morph that has changed the bearded dragon breeding scene.
On the Web - xyzReptiles talks about what to expect from a pet bearded dragon and what they need in order to lead a healthy captive life.@ On the Web


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The trophy list for All Zombies Must Die!, which consists of 12 trophies.
- Bronze:
Kill a zombie
Kill a zombie
Fists of Fury
Kill a mutant with your fists
Watch this!
Use your first Smart Bomb
Master Craftsman
Fully upgrade a weapon with any status effect
Back with the X
Witness Rachel joining the group
Big Brain Brian
Witness Brain joining the group
Thought this was a Zombie Game?
Witness Luxo joining the group
- Silver:
A Legion of Zombies
Kill 500 zombies in one level
Can't touch this
Complete a Base quest without taking any damage
Getting to know each other
Complete all character quests
The Collector
Complete 'Dev Card Hunt!'
- Gold:
Touch Base
Complete 'Return to the Military Base'


text: The St. Luke's Cornwall Hospital Cardiovascular Institute believes prevention is always the best medicine, but when the situation calls for more aggressive treatment it is important that your physician has the right tools to provide the most effective intervention. Medical advances are coming at a rapid pace, and traditional procedure options are quickly being supplemented by less invasive and safer alternatives that can provide even better outcomes. The treatment of heart disease is experiencing just such a renaissance, and it could not come at a more important time. According to the latest statistics from the Centers for Disease Control and Prevention, heart disease is the leading cause of death in the United States. More than 600,000 Americans die each year, accounting for more than one in four deaths. Heart disease is a broad term that refers to a multitude of conditions, but the most common type is Coronary Artery Disease (CAD). This is what can lead to a heart attack. Just about everyone is at risk for CAD, and the risk factors increase with age. However, there are contributing factors that can increase your risk, such as uncontrolled high blood pressure, high cholesterol, a family history of heart disease, diabetes, and especially cigarette smoking, which is certainly highest on the list. How do you know if you are suffering from Coronary Artery Disease? A common symptom is tightness of the chest in the center beneath the sternum, which sometimes radiates to the left arm. There are also some atypical presentations such as severe nausea or reflux that won't go away with medications for indigestion, lightheadedness and just an overall feeling of being unwell. This is why being alert and paying attention to symptoms is important. Proper diagnosis is also crucial for determining the correct course of treatment. If you're having active symptoms that aren't going away, it is important to get evaluated in an emergency department right away because you don't want to miss the fact that you are having a heart attack. If the chest pain is intermittent and is not occurring at rest at that moment, you should talk to your doctor who will often refer you for evaluation with a cardiologist. The treatment plan will depend on the severity of the issue. We always start with the least invasive option. If you have a mild blockage, aggressive medical therapy and risk factor modification is the first step. If we discover a severe blockage and your symptoms persist, then it often needs to be treated directly. Again, the least invasive options such as a coronary stenting procedure, which is done through a small pinhole, are considered first. Some blockages are beyond the limitations of stenting, and those patients need open heart bypass surgery. Not all atherosclerotic plaque is the same. Occasionally, inflammation can cause cells inside the plaque to differentiate and actually produce calcium. This causes the plaque to harden over time and become resistant to dilation. These plaques are often very difficult to stent so we have to modify the plaque in some way. That's where a procedure called atherectomy comes into play. At St. Luke's Cornwall Hospital, we currently utilize the orbital atherectomy. This procedure features a high-speed rotational crown that is coated with microscopic diamond particles. The orbital motion of the crown removes plaque from a diseased artery by sanding it down into tiny pieces. Stenting severe calcification in coronary blood vessels is often difficult because of the inability to fully dilate the balloon used prior to the placement of the stent. A stent that cannot be fully expanded increases the risk of clotting around the stent (thrombosis) and the affected area narrowing again after the treatment (restenosis). Orbital atherectomy allows for these calcifications to be drilled away before placing the stent, which can provide better post-procedure outcomes. This technology provides us with a tool to treat severely calcified plaque build-up with a minimally-invasive procedure. Atherectomy allows for catheter-based stenting of coronary lesions that would otherwise require open-heart bypass surgery. We recently performed this procedure for the first time at SLCH, and the results were remarkable. The patient was discharged home the very next day. The St. Luke's Cornwall Hospital Cardiovascular Institute is committed to maintaining your heart health by providing quality care with coordinated follow-up appointments and communication between referring physicians, cardiologists and the interventional cardiologists. We encourage everyone to evaluate their lifestyle choices and make prevention a priority. It is never too late to make better decisions about your health; all you need is a goal, a plan and the desire to live better. About Dr. Anthony Patrello Dr. Anthony Patrello is an interventional cardiologist at The Hudson Valley Heart Center and the Medical Director of the St. Luke's Cornwall Hospital Cardiovascular Institute. He has particular expertise in treating complex coronary artery disease, peripheral vascular disease, heart valve disease, as well as preventative medicine. He is board certified in cardiovascular disease, nuclear cardiology, echocardiography, interventional cardiology, and internal medicine. He has received the honor of being elected a Fellow of the American College of Cardiology and the Society for Cardiovascular Angiography and Interventions. The Hudson Valley native is excited to provide cutting edge care to the community where he was raised. About St. Luke's Cornwall Hospital St. Luke's Cornwall Hospital (SLCH) is a not-for-profit community hospital with campuses in Newburgh and Cornwall, NY. The hospital is dedicated to serving the health care needs of the Hudson Valley and has achieved excellence in the delivery of compassionate and comprehensive health care services. The Joint Commission noted SLCH for excellence in Key Quality Measures in the management of Heart Attack, Heart Failure, Stroke and Surgical Care. SLCH is also recognized as an industry leader in using information technology to improve patient care, by winning the Most Wired Award for the fourth year in a row. In January 2018, SLCH officially became part of the Montefiore Health System to strengthen the delivery of health care locally and enhance access to exceptional specialty care for Hudson Valley residents.


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Ravasio — Howard
STEUBENVILLE — Bernard Ravasio of Bloomingdale and Jo-Anna Ravasio of Steubenville announce the marriage of their daughter, Lucianna, to David Howard, son of Michael and Johanna Howard of Kelowna, Canada.
The couple were united in marriage at Castello della Castelluccia in Rome, Italy on June 15.
The ceremony was held in the cloister of the medieval castle. Escorted by her father, the bride wore a fitted lace dress with an illusion back, bridal buttons and lace cuff sleeves. She carried a bouquet of satin roses.
The bride is a graduate of Catholic Central High School, the University of Notre Dame and Queen's University Belfast. The groom is a graduate of the International School of Zug in Switzerland and attended Washington State University.
After a honeymoon in Rome and Sapri, Italy, the couple relocated to Dublin, Ireland.


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4 Red Wines to Enjoy This Summer
Vino 301's 2017 Red Wines Picks
Red wine can be enjoyed year-round. People who love red wines LOVE red wine. They would never consider switching to white wine because it is summer. Red wine lovers just switch to a lighter red during the summer. If you are a serious red wine drinker or thinking about trying a summer red, here are Vino 301's recommendations for summer red wines.
Summer Sipping
Red wine does not evoke images of sipping a cool glass of wine on the deck or rocking on the porch swing with a glass of wine. We have a red wine that will forever, change your mind.
2015 Chambourcin Melot, Boordy Vineyard
The Chambourcin Merlot blend is a pleasant sipping wine that can be served chilled. We recommend chilling it an hour before serving. It has aromas of fresh raspberries. The residual sweetness from the grapes is a welcomed surprise to the palate. It is a semi-dry wine.
Grilled and Smoked Meats
Grilled hamburgers, steaks, lamb, ribs or smoked brisket generally warrant medium to full bodied red wines. These red wines have the muscle to stand up to these rich, layered meats. Full bodied reds have as much flavor as the food.
2013 Cabernet Franc Blend, Chateau Bu-De
The Cabernet Franc is a blend of 78.6% Cabernet Franc, 16.1% Cabernet Sauvignon and 5.4% Merlot. Big bold fruit flavors like cherries, raspberries are on the nose. Peppery notes, like black pepper, linger on the palate. This medium body wine is perfect with steak and lamb.
White wine with white meat is the guide most people use to pair their food with wine. This is a safe rule to use for the most part, but there are times you can break the rules. Today we are breaking the rules. Grilled chicken on the bone or a fatty pork chops can be enjoyed with a red wine.
2013 Barbera, Crow Vineyard
Do not let the Barbera's dark color fool you. It's color is synonymous with full body red wines, but is composition is really a medium body wine. Bright cherries, and strawberries are on the nose. Green pepper and cinnamon is on the palate. Medium tannins, high acid and a medium finish describe the wine. It will complete fatter white meat dishes without stealing the spotlight.
We are breaking the rules again and pairing red wine with white meat. Light red whites do well with big flavor fish. Salmon, tuna, swordfish and other fatty, meaty fish can hold its own when it is enjoyed with a light red wine.
Sangiovese, Running Hare Vineyard
Running Hare's Sangiovese is a light body red wine. Sour cherries and currants on the palate and nose. It has minerality and medium tannins. The wine's medium acidity is why it does not over power the fish's flavors.
You can purchase the wines online, just visit their websites. You can contact the vineyards to locate where you can purchase the wines at local wine stores or restaurants.
10 Great Thanksgiving Value Wines
Thanksgiving Tips and Picks:
10 Great Thanksgiving Value Wines
Thanksgiving is right around the corner. Are you ready for the prepping, the cooking, and the entertaining? If not, no worries. 10 Great Thanksgiving Value Wines is the second installment in Vino 301's Selecting Thanksgiving Wines series. Selecting Thanksgiving Wine series hopefully helps to increase joy during your holiday and reduces stress.
We selected 10 wines to serve with your meal. These wines are under $25.00 and most importantly they are SO YUMMY! They pair well with most dishes. You can entertain with these wines as well. You will be a rock star this holiday. Most of them can be located at your local wine store.
10 Great Thanksgiving Wines
Wine Value Shopping Tips
Before you step foot in your wine store, keep in mind the following:
Call ahead – This is the busiest time of the year for the liquor industry. Many stores make 70 percent of their profit between Halloween and New Years. They are offering special for bulk purchases. Ask what specials are they offering, like 10% off case purchases and when are the specials available. Make sure you ask can the case be mixed. There is greater value with mixed case (e.g., different types of wine in a case).
Shop for the holiday season, not for a day – Realizing this blog's subject is Thanksgiving; however, do not just purchase for that day. Save time and money. You can avoid multiple trips to the store when you purchase in bulk. There is value in purchasing in bulk. You can also serve the wine throughout the holiday season, or give bottles as gifts.
Avoid the displays – I cannot say with 100 percent certainty, but the wine on the displays did not make Wine Enthusiast 90 point or higher ranking. They are more for promotional value. You may not get the best value for your purchase.
Taste, taste and taste some more – Remember wine store owners are joyous this time of year because they are making money! They want you to buy. They are going to offer FREE wine tastings at least once a week, if not more. Shop owners are hoping you will try it, you like it, you will buy it. I am not encouraging you to buy everything, but I am encouraging you to try everything. You cannot always know what you like by solely reading the label. The bottle is open, try it.
Hope you have a safe, joyful, and enjoyable Thanksgiving holiday. Happy Thanksgiving from the Vino 301 Wine Concierge Team.
You can read more Vino 301's blogs at Latest News. Click here to subscribe to Vino 301's blog.
Fall Foliage Excursions in Maryland's Wine Country
Maryland's Wine Country Fall Foliage Excursions
Delighted Maryland's hot and humid summer is behind us; cooler days are gradually becoming our norm. As the air turns cool and crisp, this region's fall displays unforgettable foliage. Maryland's Wine Country is the perfect back drop to view the leaves changing. October and November are peak season months. Vino 301's wine tours are idea for fall foliage viewing from the comfort of the car. We spotlight a few tours and wines to sample.
Westminster Region Wine Tour & Wine, Beer and Spirits: Beverage Adventure
Westminster Region Wine Tour expands beyond Westminster, MD. Westminster is the most eastern point of the region and reaches west as far as Big Cork Vineyard (Rohrersville, MD). Big Cork Vineyard looks upon the mountains in Washington County. The tasting room has breath taking views. Enjoy sipping on Viognier during your visit. Viognier has become Maryland's "IT" grape this season. You will find it in several tasting rooms across the state. Big Cork does it extremely well. Viognier is clear and burgeoning on golden yellow. It is a dry wine with medium acid. Immediately, aromas of apricot, peaches, and floral notes are detected. Pear and honeysuckle are on the palate. The finish is long and you cannot wait to take another sip. It is a very good wine.
Wine, Beer and Spirits: Beverage Adventure is Vino 301's newest tour in the Westminster Region. This is a journey takes you Mt. Airy to Thurmont, MD. You travel through the rolling hills and you are at the foot of the Catoctin Mountains. Travel in comfort as you literally drink in local wine, beer, spirits, history and culture of Maryland's beverage industry. You can select any combination of wine, beer, and spirits at the two vineyards we are visiting. Your tour begins when Vino 301 pick's you up at one of our designated pick up locations. Your tasting adventure starts at Linganore Winecellars and Red Shedman Farm Brewery & Hop Yard. Linganore Wincellars is one of Maryland's largest vineyards and home to Maryland's newest brewery. Vino 301 completes the tour at Springfield Manor Winery & Distillery. Springfield Manor offers fine wines, gin, rum and vodka.
Chambourcin, a French-American hybrid grape, has become Maryland's native grape. Springfield Manor's Chambourcin 2013 is a favorite to have during autumn. It is a clean, ruby red dry wine. By its color alone, you would expect high tannin. Your expectations would be wrong. It has medium tannins and acid, and traditional black fruit characteristics like black berries and currants. Vanilla and clove spices on the nose. When Springfield first opened and released its first Chambourcin vintage was fair and had room for improvement. Its current vintage is very good is shows complexity and winemaking maturity.
Patapsco Region Wine Tour & Chocolate and Wine Tour
Patapsco Region takes you to the heart of horse country in Baltimore County. The drive through this region is an array of spectacular tree-scape roads of yellow, orange and red. It is the perfect back drop to wine tasting. Along this trail is Boordy Vineyard. Boordy Vineyard's Landmark Albariño 2015 was the 2016 Governor's Cup Winner. There is an emergence Albariño in Maryland you see in western Maryland as well as Baltimore. Boordy's wine is a medium bodied, with notes fresh green apples, and grapefruit. Clean, pale yellow appearance is crisp on the palate. Albariño typically high in acid, the Boordy Vineyard wine has medium acid. It is a very good wine.
The Chocolate Wine Tour is located in the Patapsco Region. Vino 301 visits Parfections (Cockeysville, MD). Parfections chocolate truffles and bark are paired with Maryland wine. The wines served are selected from regions across the state. As we like to say, "Your chocolate pairing is a trip through Maryland's wine country without leaving your seat." Parfections truffles are seasonal. They have flavors like pumpkin spice, cranberry and walnut, and many more truffles. Not to worry, they have the favorites like chocolate mousse, honeycomb, and dipped bacon in chocolate.


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18/02/14: NEW WORK: Starburst by Dan Price was premiered by the Greater Manchester Youth Band last weekend.
01/01/14: Happy New Year from Yewden Music!
25/12/13: Merry Christmas from Yewden Music!
05/12/13: World Premiere: Angelicus was performed for the first time this evening to a capacity
audience at Halifax Victoria Theatre. Many thanks to the Black Dyke Band with Dr Nicholas
Childs, and the Halifax Choral Society with John Pryce Jones.
20/11/13: World Premiere: Enter the Dance was performed for the first time this afternoon by Sheona White
and the University of Salford Brass Band. Many thanks to Sheona, and Brett Baker who conducted
the band.
NOTICE: We now accept online payments through PayPal. You don't need a PayPal account to use this facility. Just click to purchase any of our products and the transaction will be handled on PayPal's secure server.
Welcome to Yewden Music, publishers of high quality music for brass & wind ensembles. With many years' experience in composing and publishing for several of the world's premiere brass and wind ensembles, Yewden Music provides top quality products of excellent value from our in-house composers and arrangers, Dan and Andrea Price. Please browse our catalogue, or for new commissions please contact us.
With many thanks to the following brass bands and other ensembles for commissioning and performing our music:


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Alesis announce two new interfaces at NAMM 2013: the iO Hub and the Control Hub. The Alesis iO Hub is a 2-channel USB audio interface that is also compatible with iOS devices (iPad, iPhone and iPod Touch), whereas the Control Hub is essentially a MIDI interface with an audio output (also compatible with a computer via USB or iOS devices).
The Alesis iO Hub features two XLR/1/4" jack combo inputs with individual gain controls and it can connect to an iOS device using Apple's new Lightening connector. It also features phantom power for using condenser microphones and a switch for direct (zero-latency) monitoring. It is powered either by a USB connection or your iOS device, making it extremely portable, although it does require a standard 9V battery to supply phantom power.
The Alesis Control Hub features a single MIDI input and output. Just like the iO Hub it connects to your computer via USB or to your iOS device via Apple's new Lightning connector. The Control Hub can connect to pretty much any MIDI gear you want and it also handily includes headphone and stereo 1/4" jack audio outputs. The Alesis Control Hub is also powered via USB or iOS so there is no need for a power supply.
For more information on either the Alesis iO Hub or Control Hub, click the link below or give us a call on 01202 597180.
Alesis Control Hub - More Info/Buy
***If you're interested in buying and you have seen it cheaper elsewhere, please call us or use our
and request our PRICE MATCH service***
As well as receiving our first rate customer service you can also claim money off your next purchase with our loyalty points scheme and receive a 3 year warranty if you sign up to our FREE VIP Club (click here for more infomation). Many of our items also come out on a FREE next-day delivery service to mainland UK customers, so you won't be left waiting!
Also, if you want to keep up with all our latest offers, competitions, news and videos, why not follow us on Facebook and Twitter?


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Steve's Conclusion
Steve's SnapShot
Timing Test Results
Bottom Line
|The GE E1486TW boasts some appealing features for its affordable price tag. It shoots nice pictures, but is lacking in some areas, which explains the reduced price when compared to its competition.
Pick This Up If...
|If you are looking for a touchscreen enabled digicam, but are on a tight budget.
Like past models, the E1486TW feels well built, with a good weight to it. Although small, the camera still fits well in our hands, and due to the touchscreen there are very few controls mounted on the body. All you will find are the power and playback buttons as well as the shutter release with the zoom controls mounted around it. Everything else is handled by touching the large 3.0-inch screen. The LCD seems to have an anti-reflective coating, as there are only a few angles in which is reflects strong light. I did find that it collects finger prints quite easily, so be sure to wipe it off often.
The touchscreen system itself worked Ok. It wasn't the most responsive system I've used, but not the worst either. We especially found it difficult to use during playback mode, where the camera's response to our touch was a bit slow. If you touched the screen to quickly, it would not respond. I was also disappointed with the playback zoom function. While you can zoom in quite easily by using a diagonal sweep with your finger or using the telephoto zoom control, once magnified you can not scroll around the frame. This function has been standard on digicams for years, and pretty much made the zoom function worthless on this camera as it only enlarges the center of the frame.
Image quality from the E1486TW was average for a compact camera. It produces nice looking 14-megapixel photos outdoors that display good exposure and pleasing color balance. Images are also relatively sharp, however when viewing at 100% you can see a large amount of luminous noise present throughout the photo (much more easily seen in on dark objects or in shadow areas). This can cause photos to look a bit soft when critically viewing them, however it is unlikely to be seen in you small to mid-sized prints; larger ones on the other hand could possibly be affected. Image noise stays pretty consistent up to ISO 800, however after this setting images are pretty much unusable in my opinion. One small annoyance we found was that the date imprint function is set to On by default. I noticed this after I had taken all of our typical outdoor photos.
Indoors the E1486TW did well capturing close-up portraits, just be sure you are no more than about 6-7 feet away from your subject. The flash is tiny, like most all compact cameras, and will not be able to properly illuminate subjects beyond that range. The Face Detection system seemed to find faces within the frame rather quickly, which will help ensure that your family and friends faces will be nice and sharp.
Like most digicams on the market today, the E1486TW boasts a HD video recording option at 1280x720 (720p) resolution. You can also choose smaller standard definition options for 640x480 and 320x240. The frame rate is selectable from 15 or 30fps. Our video samples looked Ok for a sub $200 camera. Videos play back nice and smooth then using the 30fps quality setting, and the exposure system seems to do well. There is a good amount of compression noise, even outdoors. The lower the lighting, the worse this will get. One annoyance we found was that movie mode will not start recording unless focus is achieved. Therefore, if you just mash the shutter release to start recording a movie, it will not start. You have to wait for the slower AF system to lock focus first. Also Digital zoom is the only magnification option available while recording, the optical zoom is inoperative. As you can see from our movie sample, it's degrades quality and causes the video to get choppy while you are zooming; it would be best to only use this option sparingly.
Battery life on this model is quite bad. Power is supplied by a small 3.7V, 700mAh Li-Ion rechargeable battery pack, which is charged in the included AC charger. While testing the camera, we were only able to capture about 100 photos and some other brief tests before it posted a low battery indicator. They claims you cna get about 160 photos, which might be possible on a single outing, but it pushing it. A second battery pack is pretty much a necessity with this camera, especially if you are planning on taking it with you on vacation.
Bottom Line - GE's E1486TW is one of the cheapest touchscreen digicams on the market today. This model is loaded with high-end features at an affordable price tag of US$199 or less. However, you get what you pay for. While the camera captures decent photos and offers good burst mode options, it's slower standard shooting performance, substandard touch system, and horrible battery life help reflect why it's so much less than the competition. Therefore, we highly recommend you ponder on the features that mean most to you, and look at various models in the Sub $250 category. While you may not get a cool touchscreen, for $200 you can find a camera with superior performance and image quality.
Visitors of Steves can visit the stores below for real-time pricing and availability. You can also find hot, soon to expire online offers on a variety of cameras and accessories at our very own Camera Deals page.


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General information
Crohn's disease is one of the two major types of inflammatory bowel disease (IBD), the other being ulcerative colitis. The main difference between the two conditions is that, whereas Crohn's disease can affect any part of the digestive tract, ulcerative colitis affects only the large bowel and the rectum. Crohn's and ulcerative colitis are estimated to affect around 15,000 New Zealanders.
Both Crohn's disease and ulcerative colitis are believed to be autoimmune diseases, where the body reacts against its own tissues.
The precise cause of Crohn's disease is unknown. There are, however, several established risk factors, including the following:
- Family history (genetics)
- Smoking
- Use of oral contraceptives
- Ethnicity
- Environment.
Crohn's disease is more common in people who have family members with the disease, which indicates that genes may play a role in increasing susceptibility to developing the condition. However, most people who have Crohn's disease don't have a family history of the disease.
Signs and symptoms
Typical symptoms in a person with Crohn's disease are chronic diarrhoea and abdominal pain and tenderness. Other Crohn's disease symptoms include:
- Rectal bleeding
- Fever
- Weight loss, and loss of appetite
- Nausea, vomiting
- Malnutrition, and vitamin deficiencies
- Tiredness, lethargy
- Bone loss (osteoporosis)
- Depression, anxiety (associated with coping with the condition)
- Stunted growth in children (which may occur many years before digestive symptoms appear).
Because there is no cure for Crohn's disease the primary goals of treatment are the following:
- To achieve the best possible control of the inflammation with the fewest adverse effects from medication
- To permit life to be lived as normally as possible
- In children, to promote growth with adequate nutrition.
Medication is frequently effective in calming down flare-ups for long periods, and surgery can bring prolonged relief of symptoms that are not controlled with the use of medication.
Lifestyle changes
Further support
For further support and information get in touch with Crohn's & Colitis New Zealand or visit their website.
Crohn's & Colitis New Zealand Charitable Trust
Free phone: 0800 ASK IBD (0800 275 423)
Email: firstname.lastname@example.com
Website: crohnsandcolitis.org.nz
Gearry, R.B., Day, A.S. (2008). Inflammatory bowel disease in New Zealand children – a growing problem. NZ Med J;121(1283):5-8.
O'Toole, M.T. (Ed.) (2013). Crohn's disease. Mosby's Dictionary of Medicine, Nursing & Health Professionals (13th ed.). St Louis, MI: Elsevier Mosby.
Ghazi, L.J. (2017). Chron disease (Web page). Medscape Drugs and Diseases. New York, NY: WebMD LLC. http://emedicine.medscape.com/article/172940-overview#a1 [Accessed: 02/08/17]
Su, H.Y., et al. (2016). Rising incidence of inflammatory bowel disease in Canterbury, New Zealand. Inflamm Bowel Dis 2016;22(9): 2238–44
Triggs, C.M., et al (2010). Dietary factors in chronic inflammation: food tolerances and intolerances in a New Zealand Caucasian Crohn's disease population. Mutation Research 2010;690(1-2):123-38.


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Pat Curtin, Kelli Matthews and I conducted a survey of the Millennial generation of employees who work at public relations agencies.
We explored our participants' opinions about the usefulness of Shannon Bowen's model of ethical decision making. Here is the model we explored:
This Kantian model and an explanation of it can be found in the following source:
Bowen, S. (2005). A practical model of ethical decision making in issues management and public relations. Journal of Public Relations Research, 17(3), 191-216. doi:10.1207/s1532754xjprr1703_1
Highlights From the Study
- We found through our pretest that we needed to update some of the language used in the model so it would resonate with Millennials. You can see the updated wording in our study.
- Most Millennials found the revised six questions in the model to be very useful. The next step in this research is to explore the actual use of the model by an organization. If your organization is interested in adopting the model and engaging in further testing of it with us, please contact me at derville(at)uoregon(dot)edu.
- Minorities reported significantly more constraints from job security and personal ambition than did non-minorities, which suggests that employers can do a better job of relationship building with minority employees. More research is needed to parse out differences among races and ethnicities to avoid broad dichotomies of minority versus non-minority.
- Millennials expressed that they have far better relationships with their agencies when they are empowered to make their own decisions regarding ethical dilemmas.
- About 75 percent of participants disagreed with the model's assumption that job security, personal ambition and workplace politics would interfere with their ability to make ethical decisions. Qualitative research is needed to explore why participants answered in this way.
- For more findings, you can read our study in PRSA's PR Journal (volume five, issue two).
This research was supported by the Public Relations Society of America Foundation and the University of Oregon. This study won the Jackson-Sharpe Award, sponsored by Jackson, Jackson & Wagner and Likely Communication Strategies, at the 13th annual International Public Relations Research Conference. We thank Shannon Bowen for her feedback on this study.


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Beginning with the ASCD SmartBrief.
National PTA signs Kindle to sponsor reading program
Amazon's Kindle has been named the exclusive sponsor of the National PTA's Family Reading Experience, a newly created program that encourages children and families to read together. Fast Company online (2/28)
ITunes U downloads hit huge milestone
The Washington Post (2/28)
How do iPads affect learning?
Researchers studying the use of iPads in classrooms in California's Encinitas Union School District say the devices generally are favored by students and parents. In the district, where every student in grades 3 to 6 has an iPad, 90% of students said the technology has helped them learn — especially when used in math lessons. However, some parents say they want to ensure the technology does not replace hands-on learning, and teachers say the iPads can be distracting for students if not managed properly. The Coast News (Encinitas, Calif.) (3/1)
Also the SmartBrief for EdTech.
Building home-school connections using technology
Cellphone and voice services can help educators build the home-school connection, writes Lisa Nielsen, a public-school educator and administrator. In this blog post, Nielsen recommends the phonecasting service iPadio, which can help teachers create podcasts; Voki, which allows people to develop and share recorded messages using an avatar; and Google Voice, which provides free phone numbers. SmartBrief/SmartBlog on Education (3/4)
Wristbands aim to shed light on student wellness
An Illinois school district is using a portion of a $15,000 grant from Fuel Up to Play 60 to purchase 60 wristbands made by Fitbit Flex that will track students' steps taken, distance traveled, active minutes, calories burned, the quality of sleep and the hours slept. The effort is intended to help reduce teenage obesity, and officials said students will take the wristbands home for several days and potentially use the data to make healthier choices. Chicago Tribune (tiered subscription model) (3/4)
Apple seeks to end lawsuit involving in-app purchases by children
Apple is seeking permission to wrap up a case involving the allegation that it lured children into buying virtual goods through addictive games without their parents' permission. The company appeared before U.S. District Judge Edward J. Davila to say it wanted to send a notice to 23 million iTune users, informing them of the settlement, which pays aggrieved parents in iTunes credit or cash. The plaintiffs do not oppose Apple's efforts. Bloomberg (3/2)
N.Y. company to sell Android-powered touch-screen tablet exclusively to schools
USA Today (3/6)
Why some schools are making the switch to digital textbooks
For schools using electronic textbooks, students are receiving up-to-date information about current events, research and other matters as publishers can make almost-instant changes. Educators and others say the benefits of the switch to electronic textbooks include the speed at which they can be updated, the lower cost and the vast resources they open up for students. However, officials also point out that many students do not have access to such technology and stress that districts must focus on teacher training when rolling out digital textbooks. U.S. News & World Report/The Associated Press (3/6)
Teacher suggests ways to use iPads in classroom lessons
The Guardian (London)/Teacher Network/Teacher's blog (3/6)
Calif. school uses federal grant to pay for tablet rollout
A California school district plans to provide tablet computers for all students as part of a $2 million technology upgrade. Officials say that 81% of the project is being paid for through federal grants. In the Central Unified district, about 30 teachers now are using Samsung Galaxy tablets, and 900 will be using them next year ahead of 2015, when all students will receive tablets. KFSN-TV (Fresno, Calif.) (3/6)
How BYOD is expanding learning opportunities for students in Ala. county
AL.com (Alabama) (3/7)
As well, the ASCD Worldwide Edition SmartBrief
Learning management system increases access to mobile learning
The Stanford Mobile Inquiry Learning Environment, which has launched in India, Argentina and the US, allows students to use cellphones — primarily Android devices — to create, share, answer and evaluate academic questions. A similar project is under way in Southeast Asia that would allow access using tablet computers. The work is done through a learning management system that does not require access to the Internet, making it ideal for communities worldwide with limited resources, the project's creator Paul Kim said. KQED.org/Mind/Shift blog (28 Feb.)
Back to the regular Google News alert for mobile learning.
MDGs: how mobile phones can help achieve gender equality in education
The Guardian
Mobile phones are increasingly affordable for women and girls in developing countries, offer additional freedom in deciding when and where to use them for learning, and can provide on-demand access to voice- and text-based instructional materials.
See all stories on this topic »
Upside Learning Explains Why Mobile Learning is the Future of Workplace …
PR.com (press release)
Pune, India, March 08, 2013 –(PR.com)– Upside Learning is one the few learning technology solution companies that has believed in the potential of mobile devices for workplace learning, even when mLearning was in its nascent stage. The company has …
See all stories on this topic »
Next, the Google Blog alert for mobile learning.
Mobile Learning: New Report from UNESCO Provide Perspectives …
By fsaba
unesco_logo_0 A New reports issued by the United Nations Educational, Scientific and Cultural Organization (UNESCO) focus on policy issues educators must consider to adopt and promote the use of mobile learning. The firs report titled The …
Finally, the Google Web alert for mobile learning.
Mobile Education – Mobile Learning
Mobile technology is increasingly used to encourage interaction and create a more active learning experience, from elementary to high school and beyond.
Mobile learning | Skeptoid
Mobile learning. Posted on March 3, 2013 by Bruno Van de Casteele. When do you listen to podcasts such as Skeptoid? I listed to my favorite science and …
Words2Learn Mobile Learning Project – National College Transition …
We found that 38% of adult learners surveyed own smartphones. Now add to these ipads and tablets, and it is easy to see that mobile technology is clearly part …
Mobile Learning Apps Free During SXSWedu: Float Mobile Learning
Float Mobile Learning apps RabbleBrowser and Sandbox, normally $2.99 apiece , available for free during SXSWedu.
Mobile Learning Framework – HTML5 Framework for Mobile Learning
An HTML5 framework for the development of mobile learning solutions that delivers learning content to learners across multiple channels and devices.
Steps to Mobile Learning Success
Presentation given at the Illinois Computing Educators Conference March 1, 2013.
UNESCO Mobile Learning Week 2013: Scratching the surface …
Mobile The recently hosted UNESCO Mobile Learning Week (MLW) 2013 set out to answer three vital questions: how can mobile technologies support literacy …
Why Mobile Learning Is The Future Of Workplace … – Upside Learning
Mobile Learning Infographic illustrating Why Mobile Learning is the Future of Workplace Learning.
– Guide to mobile learning for school, district administrators
The Resource for Education Technology Leaders focusing on K-12 educators. Site contains a Software Reviews Database, articles from Technology & Learning …
3 Ways to Know That Your Company Needs Mobile Learning
We've compiled several questions you should ask to determine if your company will benefit from implementing mobile learning.


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In the Powershell section, the column with the terms/commands is set to centered paragraph formatting rather than left side alignment. It makes it harder to scan through looking for the term you want. It looks like all the other databases have this column left-aligned.
The reason that the indentation on the PowerShell page is a little irregular is that PowerShell cmdlets consist of a Verb-Noun e.g. Get-Eventlog
There are only a few common verbs Get-, Set-, New-, Remove- etc so it makes sense to list things in A-Z order by the noun. That in turn makes the indentation untidy because the Verbs are all different lengths.
A further complication is that all cmdlets have aliases, such as DIR for Get-ChildItem, which you might reasonably expect to find under D.
So yes it isn't perfect but is done that way for a reason, if you still struggle to find things, use the search.
Pages: 1
Topic closed


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Words of Thanks
From an event in DC on Oct 15, honouring Fran O'Brian's Steakhouse' s owners with an award for having served free Friday night dinners to wounded soldiers for the last year:
It was, however, the words of Humaila Akrawy, an Iraqi citizen, that were perhaps the most poignant of the evening. Her sister was killed for working with Americans, her brother was killed by Saddam Hussein's secret police, and another sister was targeted by Uday Hussein and had to be smuggled out of the country.
She spoke of the Iraq's gratitude to America and the troops who helped to free the country and its people from the terrorism of Saddam Hussein. She said the troops are, indeed, winning the war, because if they weren't, the insurgents would ignore them.
"I can never tell you how grateful I am and how grateful my people are for your sacrifice. You left your homes … to fight for a people you have never known," Akrawy said. "When the sun sets over the deserts and mountains of Iraq, the good people of Iraq look at the West and are happy to know that the sun is rising to the people who rescued us from the darkness and evil of Saddam.
"Never think that your work in Iraq was wasted," she continued. "Never let anybody to say that you shed your blood in vain. You have given the people of Iraq, of Afghanistan, the chance to be free."
Tuesday, October 19, 2004
Words of Thanks
Posted by John at 10/19/2004 05:17:00 PM


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Harinordoquy braced for huge challenge
Biarritz stalwart says victory away to European Champions Leinster would be 'a miracle'
Imanol Harinordoquy: "It's the reigning European champions, at their place too, so for us it would be a big achievement, or even a miracle, to win against them."
They will come face to face at the RDS on Saturday, but in a different world Brian O'Driscoll and Imanol Harinordoquy could have been team-mates.
As his contract with Leinster neared an end in 2005, O'Driscoll famously paid a visit to Biarritz, at a time when the French club were a major force in both the Top 14 and in Europe.
Ahead of this weekend's Challenge Cup semi-final, Harinordoquy said he was not too aware of the incident at the time.
"No, he didn't come into the dressingroom so we didn't see him," the Biarritz captain laughed. "We hear about a lot of things that don't happen. So it remained a rumour, even if we would have liked to have him in our squad.
Strong period
"In 2005 we were champions of France and we got to the semi-finals of the European Cup. In 2006 we were champions of France and we got to the final of the European Cup.
"It's true that it was a strong period for Biarritz Olympique but we didn't know how to attract players like O'Driscoll, or we weren't able to."
Things have changed dramatically since then, with the iconic backrow conceding that the Basque club have struggled to compete with some well-bankrolled French rivals.
"It's difficult because we don't have the squad that teams like Leinster have. In France there are teams that are better structured than us and are more professional, like Clermont, Toulon, Toulouse and Montpellier. It's difficult to compete with those teams over time but in one match we're capable of beating everyone."
After missing out on the playoffs, Biarritz saved their season last year by beating Toulon in the Challenge Cup final. Now they face a similar scenario. "It's been a frustrating season because we've alternated between good and less good. In the end, we're lacking the points needed to finish in the top six, even though I think it was within our reach."
"We know as well that it will be more difficult than last year," he continued. "It's the reigning European champions, at their place too, so for us it would be a big achievement, or even a miracle, to win against them. But it's a match of rugby and in rugby anything is possible."
Harinordoquy only took up rugby at 15 after being forced to take almost a year out of all sport due to growing pains. Since then the 33-year-old has developed into one of the fiercest competitors in the game and he's hoping Biarritz can raise their game to Leinster's level.
"They have practically no weaknesses so we have to concentrate on ourselves, and our defence. We'll have to be very tough in our attitude, notably at the breakdown, because that's an area where they're very efficient.
"It's simply about keeping the ball and making the most of when we're on top."


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Sting Sells Personal Collection
LONDON -- Works from the Art Collection of the pop singer Sting & his producer partner Trudie Styler will be offered at auction at Christie's in London on 24 February 2016.
Art collectors of ArtKabinett social media network will be excited to bid at this auction.
Formed over the past 20 years and lovingly housed in their former family home at Queen Anne's Gate in London, the collection vividly captures the couple's knowledge and passion for Art and Design.
Over 200 lots will be offered from the collection, which represent remarkable quality and breadth – from bold abstracts by Ben Nicholson and Alan Reynolds and striking Mapplethorpe photographs to sophisticated 20th century furniture and lighting that complement the bold primary colors of Matisse's Jazz series and the playfulness of ceramics by Picasso.
This sale marks a wonderful opportunity for new and established collectors to choose from an inspiring array of works with notable provenance, collected with passion and knowledge. Estimates range from £1,000 to £500,000.
Their home at Queen Anne's Gate effortlessly combined luxury, rarity and color -- a skillful balance that created the ultimate London home. Each work of art was carefully chosen and the resulting collection is a testament to Sting and Trudie Styler's informed eye for Art and Design.
Alongside works by Matisse, Picasso, Mapplethorpe and Nicholson, the collection includes Sting's Steinway piano, which occupied pride of place in the music room at Queen Anne's Gate.
Important Works
The collection features a number of important works by the great artists of the 20th and 21st centuries, led by Ben Nicholson's March 55 (amethyst) (estimate: £300,000-500,000).
Painted in 1955, this work dates to a crucial phase in Nicholson's work, between the late 1940s and early 1950s, which secured him a position as the leading British abstract painter on the international stage. The present lot exemplifies his harmonious combination of fluid drawing and a relatively muted palette, using washes of color to add subtle forms to the composition.
Henri Matisse's Jazz portfolio is a celebration of life and a riot of pure colour and form (estimate: £250,000-350,000). Created in 1947, it marks a radical departure from the artist's previous work and is today considered one of the greatest and most influential print series of the 20th century.
Works by other masters of modern art include Pablo Picasso's lithograph Le Corsage à Carreaux, 1949 (estimate: £30,000-50,000), and prints by Georges Braque and René Magritte. Among the contemporary prints selection are pieces by artists of the present day, Mimmo Paladino and Carsten Holler, among others.
A highlight from the selection of drawings is Gustav Klimt's Study of a Young Woman in Stockings(estimate: £25,000-40,000). Depicting a striding female nude in her stockings, this work is from a series of drawings of the human figure in movement that Klimt completed in 1906-1907.
Contemporary Focus
Contemporary highlights include Keith Haring's Untitled (estimate: £70,000-100,000) and Zeng Chuanxing's Paper Bride (White) (estimate: £30,000-50,000), both iconic works from the art movements they represent. Indeed the carefully selected works within this collection act as key examples of the zeitgeists within which each artist worked. Executed in 1984 and derived from his subway vernacular, Haring's figures are archetypal of the energy and emerging art scene of the 1980s that he championed alongside his contemporary Jean-Michel Basquiat.
Twenty years later in the Post-cultural revolution era, Zeng Chuanxing's Paper Bride (White) displays the heavy influences of western iconography on the emerging contemporary art scene of China in the 2000s.
Of the striking photographs on offer by Robert Mapplethorpe, which revel in the sensual quality of nature, a highlight is Calla Lilies, 1983 (estimate: £30,000-50,000)
Sting and Trudie Styler's support for young contemporary artists of the 21st century is highlighted by a striking series of panels by Russian artist Veronica Smirnoff which were specifically commissioned for the staircase at Queen Anne's Gate.
The collection is complemented with works by Emily Allchurch and Giles Alexander that further underlines Sting and Trudie Styler's commitment to and support for young contemporary artists.
In addition the furniture and design in the collection comprises works by important Post-War masters including Yves Klein.
Radiating with the artist's signature pigments Table Rose (estimate: £20,000-30,000) and Table Bleau (estimate: £20,000-30,000) are a testament to Yves Klein's relationship with color and its 'infinite presence' and the emotive reaction it had the power to evoke.
Other significant pieces include exquisite Line Vautrin and Piero Fornasetti mirrors, furniture by Jacques Adnet and George Nakashima, and Jean Besnard ceramics that capture the essence of nature.
Works from the Home of Sting & Trudie Styler to be offered at Christie's King Street on 24 February 2016


text: Ayessa 0 Report post Posted October 17, 2013 I was wondering about making decorative logs to go into a gas fireplace. What kind of clay could/would stand up to the heat? Any advantage low fire or hi fire? Could the log be glazed or should it be left unglazed? My old logs were just textured concrete. Thanks! Ayessa Quote Share this post Link to post Share on other sites


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It's time for Episode 5! On this week's Static Podcast we chat about online scams, the resurgence of tabletop games, the pros and cons of going off-grid plus we explore: are video games really good for you?
We also answer your question: is Googling everything a risk to your online security?
Image: Shutterstock
Watch the expanded show in video or subscribe to the audio feed via iTunes and Pocket Casts.
Host Rae Johnston is joined by Lifehacker Australia's Chris Jager, Gizmodo Australia's Hayley Williams and Alex Walker from Kotaku Australia.
As always, a big thanks to The X Studio.