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Football coach talks failure and recruiting
Being in this business, I tend to peruse and read a lot of things.
That includes many things I know I won't necessarily agree with. But, that's how you learn and get varying opinions.
You can't always ready only stuff you know you will agree with and use in your daily life.
I do read a lot of articles about coaches and those written by coaches to see their perspective inside the athletic arenas.
I came across two articles on coachingsearch.com written by Chris Vanni on Northwestern football coach Pat Fitzgerald talking about kids and recruiting.
Fitzgerald gets it.
He was a linebacker for the Wildcats and led the team to a 10-1 record in 1995 and a berth in the Rose Bowl, at the time, its first bowl appearance since 1949. He was named head coach in 2006 after the unexpected death of then-head coach Randy Walker.
Fitzgerald was named the Big Ten Defensive Player of the Year and consensus All-American in 1995 and 1996. He also won the Branko Nagurski Trophy and Chuck Bednarik Award those years, being the first two-time winner of both awards.
He was selected as the head coach at age 31 and is 70-56 after 10 seasons.
Fitzgerald talked at the American Football Coaches Association Convention earlier in the year.
"We define that as who you are when no one's watching. I failed at that miserably when I was a kid," Fitzgerald said in the article by Vanni. "I was awesome around mom and dad, I was spectacular around my girlfriend's mom and dad – now my wife – I knew how to play the game around coaches, but I was (a jerk). The minute you turned your back, you'd better look out."
Those days, according to Fitzgerald, are gone with athletes now because of social media.
He also said high school kids are afraid to make mistakes, afraid to fail because of the immediate criticism.
"Kids can't do that today. It's gone. Society has taken it away from them," he said. "Phones, Internet, blog sites. You can't make a mistake as a kid anymore. You can't learn. You can't grow.
"You can't make mistakes. It makes it incredibly challenging for us as teachers to help kids learn from failure. That's a great lesson to learn. Especially not to be afraid of it.
"I think it's pretty debilitating to watch kids who won't cut it loose because they're afraid of failure, because they're afraid they'll make a mistake and not get another opportunity."
The coach also knows part of the problems may well lie within the household.
"How many of your kids want instant gratification? 'Coach, I was on time. Where's a sticker for my helmet?'" Fitzgerald said. "How about the parents? 'Joey's a good player.' Kids don't understand it takes time. It's a process.
"I was a two-time All-American, and I have the pain of regret because I should have been a three-time All-American. It was my fault. I wasn't mature enough to know it at that age, but I didn't know what consistent hard work looked like day-in and day-out, choice after choice. If you couple that with a great attitude, you've got a chance. But it's not easy."
On national signing day, not long after his visit to the convention, Fitzgerald talked, in another Vanni article, about recruiting and the role the parents play.
"An increasingly larger part of the evaluation of the prospect, for us, is evaluating the parents. It's a big part of the evaluation," Fitzgerald said. "We have and probably will more so, and it's a private deal – I'm not going to share who and where – but when we talk about our fit, we're evaluating the parents, too. And if the parents don't fit, then we might punt on the player and not end up offering him a scholarship. That has changed during a decade. Ten years ago, that wasn't as big of a role. Now it's a big part of it.
"On the other side, it's big when it's a good fit. It's terrific. Everybody's a little bit different there, but that's the way we've seen in not only holding commitments, but having very little attrition when guys come into our program."
Fitzgerald admitted that recruiting has changed in the past 10 years and will continue to evolve with character of, not only the player, but of the family being a high priority.
"We're signing 20 new families, and if any indication of their future success is at home, when you look at these families, it's awesome," Fitzgerald said. "We had 18 of the young men on campus together, and the parents had a better time than the players. This group has built relationships for a long time. The 19 guys and our 20th, they've had a chat group together. They've been in constant communication as a group of young men. The parents created a Facebook group for each other. It's nuts. It's cool. It's really neat to see.
"When I got recruited, you got dropped off, and it was the death march to reality. You'd huddle with your family. Now, you show up for an official visit, and the families' parents are partying, and the guys have great comfort together. That's really changed a lot."
There are also increasing stories about how colleges stop recruiting high school athletes because of what they post on social media.
College coaches daily stop recruiting high school athletes because of what is posted on social media and that shouldn't surprise anybody.
You represent a lot of people when something is posted.
I represent my family, the newspapers, radio station, myself and, most of all, God.
When a high school athlete posts something, believe it or not, that athlete represents the family, the coaches, the school and the future.
I know it seems somewhat hard to believe, but it's true.
One comment that says, "Coach is killing my love for the game" will do nothing but get you in trouble with the coach and any future coaches.
Your mom and dad may behind you 100 percent, but that also means your parents are the parents Fitzgerald will not recruit.
Also not sure you want to post an Instagram pic with a few brews in the background.
Not a good look at all.
Like it or not, this is our society.
People get involved with social media wars, back-and-forths, whatever you want to call them, and it can escalate to a place that no one expected.
Yet, when it reaches that point, no one really cares why, just that it has and will read what was posted.
Do you want that look associated with you?
When you walk through the mall or go to the movies, you are representing more than just yourself, especially when you are wearing your letterman's jacket.
No one is trying to deny the way you want to express yourself, just understand that means you very well may stand solo with the expression.
(Mathison, a Weirton resident, is the sports editor of the Herald-Star and The Weirton Daily Times and can be contacted at firstname.lastname@example.com or followed on Twitter at @MathisonMike).


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The wicked desire the stronghold of evildoers,
but the root of the righteous endures.
Proverbs 12:12
Bad people live in trouble all the time but pretend otherwise. They are guided by their sinful nature which causes them numerous setbacks and makes them stumble and fall more often than they would like. Their hearts are filled with evil desires, which can adversely impact them in two different but complementary ways. Firstly the principle of reciprocity cannot be violated and every evil thought they produce becomes a boomerang against them which hits them with the same intensity with which they wish evil to their neighbors. Moreover, bad intentions make the evildoers rationalize their behavior and they end up convinced that the end justifies the means so they will do everything in their hands, usually bad actions, to achieve their goal of harming others, falling deeper in their spiritual failure.
The upright, however, allow their life to be led by the Holy Spirit of God, so they don't have to worry about reciprocity. On the contrary, their good wishes are a source of continuous blessings for them. Also the Holy Spirit imparts them wisdom and discernment so they can realize immediately whether the actions to be undertaken are good or evil before falling into temptation, giving them time to rectify. How do you live? Want to live afraid that your evil desires result in serious consequences for your life? Or do you let yourself be guided by the Holy Spirit to live peaceful and confidently? The choice is yours. Seek the Lord Jesus Christ with all your heart and he will give you life and direction. Follow his steps at all times and do not let the carnal nature dominate your thoughts and your behavior. God will give you a firm victory. Only to God be the glory!

subset: commoncrawl


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Video Games Live
Watch Monday, August 12, 2013 at 10pm on WMHT TV
Video Games Live and PBS are joining forces to create a PBS special based around the highly successful Video Games Live concert series. The breakthrough performance, taped February 5, 2010, at the Lakefront Arena in New Orleans with the Louisiana Philharmonic Orchestra, airs Monday, August 12, 2013 at 10pm on WMHT TV.
Reaching an average of more than 58 million viewers a week, PBS is the most prominent provider of programming to U.S. public television stations. "We believe the concept of introducing young audiences to an orchestra through the music of video games fits perfectly with PBS's mission in a very new and creative way," said PBS Vice President of Programming Joe Campbell. "We are very optimistic that the program will be a big success!"
Recently described by The New York Times as "captivating [and] proudly bombastic," the record-breaking and award-winning Video Games Live has continued its mission to demonstrate to the world how artistic and culturally significant video games and their music have become. Performing to sold-out crowds around the globe, Video Games Live has been thrilling gamers, families and mainstream audiences since its inception in 2002. "This is an incredible opportunity for us to reach an audience that normally may not be familiar with how far video games have come and how amazing the music can be," said prolific game composer and CEO of Video Games Live, Tommy Tallarico. "It's an honor for us to be a part of such a groundbreaking event with PBS, and I'm really excited about the potential positive effects this will have on the entire game industry and its millions of fans."
The Louisiana Philharmonic Orchestra is the only musician-owned and collaboratively managed professional symphony in the United States. The members of the LPO are dedicated to creating live symphonic music and maintaining a resident full-time orchestra that serves as an integral part of the cultural and educational life of New Orleans and the Gulf South region. "What could be more fun than to be part of this performance phenomenon," says Babs Mollere, Managing Director of the LPO. "Our musicians are looking forward to being part of an interactive evening of music and video footage with fans of all ages."


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This post contain affiliate links to a great meal planning website as well as some rebate sites. My hope is that you find something that works for you and helps with this task of homemaking.
For the first time in about a month, we are back to the routine of my husband being gone two nights a week. My routine of making meals that he does not like, but which I do, on those nights worked only so long. After a while he also wanted to be able to eat at home before heading off to class. The compromise for this week? Tomato soup. A serving is a quick fix, so no spending tons of time on a separate meal just for him. It is also a favorite of his and quick to eat, which helps. Yes, it means that his portion will cost $1 just by itself, BUT it means he will not be eating out, which will save even more on our spending.
Here are some other ways I use to save money on our grocery shopping:
- Shopping first at discount grocery stores – places like Aldi.
- Looking at sales/deals taking place at pharmacies with point programs – CVS, Walgreens, Right-Aid
- Looking at sales taking place at larger grocery stores
- Matching up online printable coupons for items I am buying
- Matching up rebates from apps – ibotta, Checkout 51, Snap, SavingStar, Shopmium
At times, I question whether it actually is cheaper to shop at stores like Aldi before going to a larger grocer. Recently I was reminded, yet again, that it really does save money. Aldi had a few cheeses on their shelves. These were new kinds that I assumed were seasonal as they were not restocked when supplies ran low. That was unfortunate as we really liked their flavors.
Last week, while at a larger grocer, directly across the street from Aldi, I saw the exact same cheese. This time, however, it was $3 more per package. Out of curiosity I check on a spreadable cheese I had been buying at another discount store; it was also several dollars more per package. A great reminder that we can still buy niceties in our grocery shopping without having to always pay the higher prices.
Ibotta was one of the first apps I began using when looking for alternatives to clipping paper coupons. It has continued to be one I use regularly.
While having the Ibotta app downloaded on my phone makes it easy to upload pictures of receipts and redeem rebates, it is not necessary. You can also redeem rebates by going to their website. As an added bonus for signing up, for a limited time if you redeem a rebate within your first 2 weeks you will earn $10 in your account.
This week I will be using Ibotta to save on several items we need to restock at home. These items will include fresh fruits, items from the dairy aisle, meat and some canned goods. Offers will vary between people, depending on stores available, parts of the country, and other factors of which I am not privy. Some weeks I use Ibotta for a lot of items, and other weeks it may be only for one or two items. I appreciate not having to clip a coupon or remember to hand it to a cashier. This helps when you feel like your arms are already full and your brain power is draining quickly.
Shopmium is another app I use, though not as regularly. I appreciate the more upscale offers they have. At times it is just what I need and contains offers I do not normally find easliy elsewhere. This is especially true living in Small Town. If you use referral code: FFUEGUVP during sign up to receive an offer for a free Lindt Chocolate Bar. Might just be the thing you need today. 😉
- Shakes
- Cereal
- Eggs, toast
- Butterscotch Banana Muffins
- Shakes
- Steel-cut Oats
- Whole-wheat pancakes, bacon
- Eat out
- Ground Beef Curry with rice
- Pizza
- Dad's Meatloaf with Tomato Relish, peas, rice
- Pulled Pork Sandwiches with potato salad
- Salad
- Chinese Barbecued Pork, rice, steamed vegetables
- Leftovers
- Broiled fish, quinoa, steamed veggies/tomato soup
- Salad
- Crockpot Chicken/tomato soup
- Black Bean Burgers
- Home Fries/Breakfast for Dinner
- Leftovers
This post linked up at OrgJunkie.com and This Week For Dinner


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Please, let me know via email when the new review on this product is available.
Eden's slimline reviews
I would certainly say this item is most definitely worth the price. Whether you are someone who uses toys a lot or you are a beginner looking to see if toys are really all the hype, this is the toy for you!
This toy is definitely worth the price. I climax more with this toy than with any other toy, and wouldn't trade it for any toy of its kind. It is a traditional vibrator, but one of the best I have used.
Well worth the price and I would buy it again. I only wish that I had bought it sooner. I can't wait to try other toys from Eden.
It's fun for a first toy, but if you're used to strong toys, avoid this one. It's worth the money, but you need to live alone, or wait for your roommates to be asleep, otherwise people will think you're being attacked by sexy bees.


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Originally Posted by Comic-Reader Lad
In other words, the guy who started this thread is Jensen Ackles, right? Jensen, you so silly!
Anyway, given that Wolverine is decades old in the comics, why can't Ackles or any older actor play him? I don't know if Ackles can be a movie star, but he shouldn't be disqualified based on his age.
As for height, now that the general public knows Wolverine as Hugh Jackman, I think it's not a great idea to all of a sudden cast someone short. Even Marvel doesn't draw him that way anymore.
What's your next recasting suggestion, a white Nick Fury? Guys, don't be crazy.
This was my 666th post. I was bein' evil.
I think Jensen has been more on the Red Hood bandwagon than anything...
Man Jon Bernthal would be a fantastic Wolverine. He just has that automatic danger look on his face that Logan should happen. Too bad he's already Punisher
DC, hurry up and make your own version of Marvel Unlimited!
Originally Posted by The Kid
Man Jon Bernthal would be a fantastic Wolverine. He just has that automatic danger look on his face that Logan should happen. Too bad he's already Punisher
Well, given that Netflix seems to be canceling the Marvel shows after their current seasons, Bernthal may just be available. He's 8 years younger than Hugh Jackman, so he hasn't aged past his freshness date.
Forum Rules


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Arup in London is a walking tour of London and exploration of the built environment by way of Arup projects. The mobile app connects users to the city and highlights Arup's overt contribution to the city's skyline, as well as less overt contributions hidden within its streets and parks.
Arup in London maps nearby buildings of interest and walking routes based a user's location. The app encourages walking by tracking distances walked with its passport function; the user is rewarded with a badge for each site visited.


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Seeing the former governor's casket there reminded me of the first time I saw Bruce King there. It was New Year's Day 1971. I was driving my '63 Falcon around downtown when I drove by the Roundhouse by way of Don Gaspar Avenue. I saw several people going in and I remembered. It was inauguration day for the new governor.
I found a place to park and went in, just in time to see him take the oath. The place was full, but the ceremony was nice and simple.
The former governor's funeral is 10 am tomorrow at the Moriarty High School gym.


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Crescent Arch Climber's Log
Dow Williams - Aug 12, 2017 9:56 am Date Climbed: Aug 1, 2017Crescent Arch
Crescent Arch and On the Lamb have become my go to routes in Tuolumne for folks who have become regulars of mine. If Tuolumne were Disney World, these two would be the most unique rides in the park at this grade level. I don't remember what I wrote previously, but the 5.10 move really is not and the first 5.9 pitch is full on as it is awkward and challenging for the grade. My preferred descent now is to carry packs to the base, take one 70m rope descent off the back left side and circumvent back to the packs, whether you are climbing a 2nd route or not. Over 25 folks on West Crack, waiting in line, no other climbers on Crescent this day. Even met some Euros who walked back to the car and were going to go wait in line somewhere else because they refused to climb Cooke Book or Crescent or some other line. You get what you deserve.
Dow Williams - Jul 28, 2015 10:15 pm Date Climbed: Jul 28, 2015Crescent Arch
Took Frank up today. Never gets old, one of my favorite moderate crack climbs in Tuolumne. Take extra slings and extra small stuff for the crux traverse, easy to pluck a lot of small gear and be well protected.
Dow Williams - Jul 22, 2013 7:10 pm Date Climbed: Jul 22, 2013Crescent Arch
With Stewart from south Tahoe. I led all the pitches. The 4th is the crux in my opinion. Had no issue with 2 and 3 (which some consider the crux). Pitch 4 was a sustained long under-cling/slab traverse but no moves at 5.10 despite the guidebook rating. All three pitches were great. As Chris references in the local guide, take plenty of slings to avoid rope drag on the traverse. Only need one 3" and nothing larger for sure. Eats up small gear.
gremlin - Aug 31, 2009 12:12 amawkward but good
crux was about the only straightforward climbing, but good route
Marcsoltan - Nov 11, 2008 5:55 pmCrescent Arch
One of the best climbs I have done in Tuolumne. Didn't care too much about the chimney 1st/2nd pitch. My buddy led that, but the crux corner went smooth for me. It sure didn't feel much harder than a 5.9. Passed a party on the route who were sunning themselves with their shoes off. They must have seen Peter Croft's video in which he says "I take off my shoes and take a nap on solo climbs." They got caught in a snow storm one pitch from the top.
kovarpa - Oct 27, 2008 12:58 pm Date Climbed: Oct 26, 2008awesome
great, great climb in beautiful weather. Started with West crack and then did this, with Michal. The 5.9 sections are not the easiest... Absolutely no one else climbing on Daff that day.
tb00957 - Oct 6, 2008 4:54 pm Date Climbed: Sep 7, 2008crescent arch
The .10b move is fine. The .9 pitches are burly. But I only led the middle 60 feet pitch, and the approach/exit pitches.


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Have questions about this item (MTB017), or would like to inquire about a custom or bulk order?
If you have any questions about this product by maxtop, contact us by completing and submitting the form below. If you are looking for a specif part number, please include it with your message.


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We sit in the sun, in the pouring rain, in the cold with blankets, on the hard metal bleachers every Saturday and Sunday and on evenings scattered throughout the week, we sit and we watch. We are the parents who choose to be in those stands watching, cheering and supporting our children on the court and on the fields of any and all sporting events that happen. Some of us are screaming and cheering and others just watching but no matter how loud or quiet our voice is we are there. We are there not to be entertained, although many times we are. We are there, not to socialize with other parents but it is a great way to get to know others. We are there to support our children whether they are the stars of the team or the bench warmers. We are there because we love them.
Our being there does so much more than at this moment we could ever know.
As a child my parents were always there but many of my friends were just dropped off. My parent's presence gave me confidence and belief that what I was doing mattered to them and was important. They built my self esteem and hugged me and let me cry when I was horrible and hugged me and smiled when I was not.
We are parents and we are there on those bleachers because our presence signifies love support and confidence for our children for the rest of their lives; simply because we are there.
Copyright 2013 Lori Hadorn-Disselkamp


text: The critix agree: there's no better way to watch movies than at home on your computer! And if you're watching movies at home on your computer, there's no better choice than the 2011 music documentary for ages 8 to 12 Justin Bieber: Never Say Never! Continue reading "Justin Bieber: Never Say Never"


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A new network aimed at sensing and controlling the physical world has been launched in Rarotonga, Cook Islands.
The purpose-built public wireless network for the so-called "Internet of Things" is a result of Bluesky Cook Islands working with New Zealand's KotahiNet. The goal is to run the network in the north of Rarotonga and then expand it to cover the whole island.
Phillip Henderson, Country Manager of Bluesky Cook Islands said, "Cook Islands can greatly benefit from being able to get real-time data about the physical world with cheap and ubiquitous connectivity. There are a large variety of potential uses- from smart electricity monitoring to better understanding the environment to knowing the location of everything."
"To help people understand the benefits and opportunities this new technology provides, there will be no charge for testing or connecting a few sensors to the Internet."
"We are happy to work with KotahiNet on setting up the public wireless network. They bring experience and skills of value to the Cook Islands."
Vikram Kumar, Director of KotahiNet said, "The vision for KotahiNet is to help unlock the benefits of smart products and services that operate in the physical world. These services use real-time data, collective intelligence, and analytics."
"KotahiNet has been operating a similar network in New Zealand for about a year and currently covers over half the country's population. In addition, we are building connected products that demonstrate the benefits of this new technology."
"The opportunity to work with Bluesky Cook Islands is ideal. It brings the benefit of wireless connectivity for real-time data quickly and economically to Rarotonga, leading the way in the Pacific Islands."
"Using the open network model from the LoRa Alliance, called LoRaWAN, is particularly well suited. It allows sensors and other smart devices to communicate over long distances, yet the battery life can be typically 5-10 years."
"By operating using the LoRaWAN specification for the European Union of 868 MHz, it allows buying sensors and other smart devices off the shelf. This means Rarotonga can tap into global suppliers and take advantage of scale economies."


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The Association defines its goal as to "foster the growth of a professional and value adding compliance testing resource to serve the needs of Australian industry."
To this end, ECTA involves itself in a range of activities, such as:
- sharing of information through activities such as interpretation working groups and internal and external education
- promotion of the value of testing results obtained from appropriately accredited test houses
- participation in standards writing committees and working groups
- provision of advice to Government on policy issues
- provision of advice to Industry on compliance and approval issues
- enhancement of the international competitiveness of Australian Industry by promoting compliance with internationally harmonised standards
- promotion of the professional development of the membership
- development and enforcement of a Code of Ethics; and
- such activities as approved by the committee and which are of benefit to the industry.
Member laboratories provide testing services to the public in a variety of areas, testing equipment to Australian and International Standards.
These include:
- electrical safety
- electromagnetic compatibility
- electromagnetic radiation
- electromedical equipment
- energy efficiency labelling
- environmental performance
- gas appliances
- lighting equipment
- performance ratings; and
- telecommunications.
ECTA also nominates members to serve on relevant Committees of Standards Australia and to make representations to government inquiries.


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The brandnewfoods.com taste panel sampled several flavors of chips at our recent taste panel session. Lay's brand New York Reuben Flavored potato chips from Frito-Lay Inc., in Plano, TX, received popular feedback from the panel overall.
What we liked:
Taste panel members commented, "I like the distinctive taste of these potato chips.", "The savory flavor of these chips is a nice twist.", "These chips would be delicious with a reuben sandwich, patty melt, polish dog and more.", "Wow - these really do remind me a bit of a real reuben sandwich.", and "This is one of the more uniquely flavored chips that I've tried in quite awhile.".
Did you know...?
- An extensive list of recipes using various Frit0-lay products can be found on the company website.
- Frito-lay's "Do Us A Flavor" contest was designed to generate consumer response to new and unique flavor and chip combination submissions.
- The current flavor finalists include "West Coast Truffle Fries", "Southern Biscuits and Gravy", "Greektown Gyro" and New York Reuben".
For complete list of ingredients be sure to read package ingredient list.
Allergen info:
Contains milk ingredients
For questions about individual ingredients and/or specifici dietary concerns, be sure to carefully read product packaging and/or contact manufacturer/distributor.
We purchased ours at our local Southern California Walmart Supercenter.
Frito-lay products are available at numerous food retailers throughout the U.S. and beyond. Selection and supply may vary. Contact your local food retailer to confirm availability.
www.fritolay.com or www.DoUsAFlavor.com


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Can I be incredibly honest tonight?
Getting a "no" from God stinks.
My family prayed and prayed for a yes. I don't mean once a day. I don't mean every now and then. I mean we consistently and constantly prayed. I prayed for this *maybe* more than I have for anything. With each prayer, I surrendered: not my will, Lord, but Your will be done.
Well, God's will and my desire didn't match.
And it stinks.
I have cried. I have struggled with Him. I leaned on a couple sweet friends, one of whom gave me permission to be angry. Honestly? It really helped to hear that.
Bottom line is, I know if God closed the door, it wasn't for us. I get it. But, that doesn't make it sting any less. It feels like a rejection, and rejection is not easy. I believed with all my heart we'd get a yes.
So here I find myself, angry and confused. I don't get it. What did I do wrong? How could I have prayed differently to get a yes?
In the quiet, He whispers to me. I've got this. My ways are better. I understand your tears, and I am bottling them up. This experience will not be wasted. Trust, sweet child.<<
raised Him, through tears, for the closed door. I praised Him for not allowing us to go down a path that He didn't intend for us to walk. He knows my heart, the heart of my family, and I am choosing to trust Him.
It's a choice with each and every prayer answered with a no, or not now. Choose trust, or choose to walk away.
I am holding firm. It's not always easy. I may continue to shed some tears. I might have to force myself to open my Bible and pray. But I will not give up.
Jennifer 💕


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We describe a 3-year-old boy with biotin dependency not caused by biotinidase, holocarboxylase synthetase, or nutritional biotin deficiency. We sought to define the mechanism of his biotin dependency. The child became acutely encephalopathic at age 18 months. Urinary organic acids indicated deficiency of several biotin-dependent carboxylases. Symptoms improved rapidly following biotin supplementation. Serum biotinidase activity and Biotinidase gene sequence were normal. Activities of biotin-dependent carboxylases in PBMCs and cultured skin fibroblasts were normal, excluding biotin holocarboxylase synthetase deficiency. Despite extracellular biotin sufficiency, biotin withdrawal caused recurrent abnormal organic aciduria, indicating intracellular biotin deficiency. Biotin uptake rates into fresh PBMCs from the child and into his PBMCs transformed with Epstein Barr virus were about 10% of normal fresh and transformed control cells, respectively. For fresh and transformed PBMCs from his parents, biotin uptake rates were consistent with heterozygosity for an autosomal recessive genetic defect. Increased biotin breakdown was ruled out, as were artifacts of biotin supplementation and generalized defects in membrane permeability for biotin. These results provide evidence for a novel genetic defect in biotin transport. This child is the first known with this defect, which should now be included in the identified causes of biotin dependency.
Rebecca Mardach, Janos Zempleni, Barry Wolf, Martin J. Cannon, Michael L. Jennings, Sally Cress, Jane Boylan, Susan Roth, Stephen Cederbaum, Donald M. Mock
The tight-skin (TSK/+) mouse, a genetic model for human systemic sclerosis (SSc), develops cutaneous fibrosis and autoantibodies against SSc-specific target autoantigens. Although molecular mechanisms explaining the development of fibrosis and autoimmunity in SSc patients or TSK/+ mice remain unknown, we recently demonstrated that SSc patients overexpress CD19, an important regulatory molecule expressed by B lymphocytes. B cells from CD19-deficient mice are hyporesponsive to transmembrane signals, while B cells overexpressing CD19 are hyperresponsive and generate autoantibodies. In this study, TSK/+ B cells also exhibited a hyperresponsive phenotype with decreased surface IgM expression, enhanced serum Ig production, and spontaneous autoantibody production. Moreover, CD19 tyrosine phosphorylation was constitutively augmented in TSK/+ B cells. CD19-mediated [Ca2+]i responses, Vav phosphorylation, and Lyn kinase activity were similarly enhanced. Studies of TSK/+ mice deficient in CD19 expression demonstrated that CD19 deficiency significantly decreased skin fibrosis in TSK/+ mice. Additionally, CD19 loss in TSK/+ mice upregulated surface IgM expression and completely abrogated hyper-γ-globulinemia and autoantibody production. CD19 deficiency also inhibited IL-6 production by TSK/+ B cells. Thus, chronic B cell activation resulting from augmented CD19 signaling in TSK/+ mice leads to skin sclerosis possibly through IL-6 overproduction as well as autoimmunity.
Eriko Saito, Manabu Fujimoto, Minoru Hasegawa, Kazuhiro Komura, Yasuhito Hamaguchi, Yuko Kaburagi, Tetsuya Nagaoka, Kazuhiko Takehara, Thomas F. Tedder, Shinichi Sato
NF-κB essential modifier (NEMO), also known as IKK-γ, is a member of the I-κB kinase complex responsible for phosphorylating I-κB, allowing the release and activation of NF-κB. Boys with an expressed NEMO mutation have an X-linked syndrome characterized by hypohidrotic ectodermal dysplasia with immune deficiency (HED-ID). The immunophenotype resulting from NEMO mutation is highly variable, with deficits in both T and B cell responses. We evaluated three patients with NEMO mutations (L153R, Q403X, and C417R) and HED-ID who had evidence of defective CD40 signaling. All three patients had normal percentages of peripheral blood NK cells, but impaired NK cell cytotoxic activity. This was not due to a generalized defect in cytotoxicity because antibody-dependent cellular cytotoxicity was intact. This abnormality was partially reversed by in vitro addition of IL-2, which was also able to induce NF-κB activation. In one patient with recurrent cytomegalovirus infections, administration of IL-2 partially corrected the NK cell killing deficit. These data suggest that NEMO participates in signaling pathways leading to NK cell cytotoxicity and that IL-2 can activate NF-κB and partially overcome the NK cell defect in patients with NEMO mutations.
Jordan S. Orange, Scott R. Brodeur, Ashish Jain, Francisco A. Bonilla, Lynda C. Schneider, Roberto Kretschmer, Samuel Nurko, Wendy L. Rasmussen, Julia R. Köhler, Stephen E. Gellis, Betsy M. Ferguson, Jack L. Strominger, Jonathan Zonana, Narayanaswamy Ramesh, Zuhair K. Ballas, Raif S. Geha
Becker syndrome, a recessive nondystrophic myotonia caused by mutations in the chloride channel 1 gene (CLCN1), is characterized by delayed muscle relaxation after contraction. The ADR (arrested development of righting response) mouse is an animal model for Becker syndrome. Skeletal muscles from ADR myotonic animals show an increased number of oxidative fibers with a lack of glycolytic fibers as well as signs of muscle hypertrophy. Through breeding ADR myotonic mice with mice harboring a MEF2-dependent reporter gene, we found that the transcriptional activity of MEF2 was dramatically enhanced in myotonic muscles. Post-translational induction of MEF2 transcriptional activity correlated with the activation of p38 MAPK and did not affect MEF2 DNA-binding affinity. Expression of class II histone deacetylases (HDACs), which repress MEF2-dependent gene expression, was significantly reduced in skeletal muscles from myotonic mice. These findings suggest that the combined effects of class II HDAC deficiency and p38 MAPK activation lead to potent upregulation of MEF2 transcriptional activity, which contributes to the long-term changes in gene expression and fiber-type transformation observed in myotonic skeletal muscles. These findings provide new molecular targets for potential treatment of congenital myotonia.
Hai Wu, Eric N. Olson
Deficiency of the membrane protein FAT/CD36 causes a marked defect in fatty acid uptake by various tissues and is genetically linked to insulin resistance in rats and humans. Here, we examined insulin responsiveness of CD36–/– mice. When fed a diet high in complex carbohydrates and low (5%) in fat, these animals cleared glucose faster than the wild-type. In vivo, uptake of 2-fluorodeoxyglucose by muscle was increased severalfold, and in vitro, insulin responsiveness of glycogenesis by the soleus was enhanced. Null mice had lower glycogen levels in muscle and liver, lower muscle triglyceride levels, and increased liver triglyceride content—all findings consistent with increased insulin-sensitivity. However, when the chow diet was switched to one high in fructose, CD36–/– mice but not wild-type mice developed marked glucose intolerance, hyperinsulinemia, and decreased muscle glucose uptake. High-fat diets impaired glucose tolerance equally in both groups, although CD36 deficiency helped moderate insulin-responsive muscle glucose oxidation. In conclusion, CD36 deficiency enhances insulin responsiveness on a high-starch, low-fat diet. It predisposes to insulin resistance induced by high fructose and partially protects from that induced by high-fat diets. In humans, CD36 deficiency may be an important factor in the metabolic adaptation to diet and in susceptibility to some forms of diet-induced pathology.
Tahar Hajri, Xiao Xia Han, Arend Bonen, Nada A. Abumrad
Pseudophosphatases display extensive sequence similarities to phosphatases but harbor amino acid alterations in their active-site consensus motifs that render them catalytically inactive. A potential role in substrate trapping or docking has been proposed, but the specific requirements for pseudophosphatases during development and differentiation are unknown. We demonstrate here that Sbf1, a pseudophosphatase of the myotubularin family, is expressed at high levels in seminiferous tubules of the testis, specifically in Sertoli's cells, spermatogonia, and pachytene spermatocytes, but not in postmeiotic round spermatids. Mice that are nullizygous for Sbf1 exhibit male infertility characterized by azoospermia. The onset of the spermatogenic defect occurs in the first wave of spermatogenesis at 17 days after birth during the synchronized progression of pachytene spermatocytes to haploid spermatids. Vacuolation of the Sertoli's cells is the earliest observed phenotype and is followed by reduced formation of spermatids and eventual depletion of the germ cell compartment in older mice. The nullizygous phenotype in conjunction with high-level expression of Sbf1 in premeiotic germ cells and Sertoli's cells is consistent with a crucial role for Sbf1 in transition from diploid to haploid spermatocytes. These studies demonstrate an essential role for a pseudophosphatase and implicate signaling pathways regulated by myotubularin family proteins in spermatogenesis and germ cell differentiation.
Ron Firestein, Peter L. Nagy, Megan Daly, Phil Huie, Marco Conti, Michael L. Cleary
Types A and B Niemann-Pick disease (NPD) are lysosomal storage disorders resulting from loss of acid sphingomyelinase (ASM) activity. We have used a knockout mouse model of NPD (ASMKO mice) to evaluate the effects of direct intracerebral transplantation of bone marrow–derived mesenchymal stem cells (MSCs) on the progression of neurological disease in this disorder. MSCs were transduced with a retroviral vector to overexpress ASM and were injected into the hippocampus and cerebellum of 3-week-old ASMKO pups. Transplanted cells migrated away from the injection sites and survived at least 6 months after transplantation. Seven of 8 treated mice, but none of the untreated controls, survived for ≥ 7 months after transplant. Survival times were greater in sex-matched than in sex-mismatched transplants. Transplantation significantly delayed the Purkinje cell loss that is characteristic of NPD, although the protective effect declined with distance from the injection site. Overall ASM activity in brain homogenates was low, but surviving Purkinje cells contained the retrovirally expressed human enzyme, and transplanted animals showed a reduction in cerebral sphingomyelin. These results reveal the potential of treating neurodegenerative lysosomal storage disorders by intracerebral transplantation of bone marrow–derived MSCs.
Hee Kyung Jin, Janet E. Carter, George W. Huntley, Edward H. Schuchman
Gaucher disease, the most common lysosomal storage disease, is caused by a deficiency of glucocerebrosidase resulting in the impairment of glucosylceramide degradation. The hallmark of the disease is the presence of the Gaucher cell, a macrophage containing much of the stored glucosylceramide found in tissues, which is believed to cause many of the clinical manifestations of the disease. We have developed adult mice carrying the Gaucher disease L444P point mutation in the glucocerebrosidase (Gba) gene and exhibiting a partial enzyme deficiency. The mutant mice demonstrate multisystem inflammation, including evidence of B cell hyperproliferation, an aspect of the disease found in some patients. However, the mutant mice do not accumulate large amounts of glucosylceramide or exhibit classic Gaucher cells in tissues.
Hiroki Mizukami, Yide Mi, Ryuichi Wada, Mari Kono, Tadashi Yamashita, Yujing Liu, Norbert Werth, Roger Sandhoff, Konrad Sandhoff, Richard L. Proia
The treatment of chronic inflammatory diseases is complicated by their unpredictable, relapsing clinical course. Here, we describe a new strategy in which an inflammation-regulated therapeutic transgene is introduced into the joints to prevent recurrence of arthritis. To this end, we designed a recombinant adenoviral vector containing a two-component, inflammation-inducible promoter controlling the expression of human IL-10 (hIL-10) cDNA. When tested in vitro, this system had a low-level basal activity and was activated four to five orders of magnitude by various inflammatory stimuli, including TNF-α, IL-1β, IL-6, and LPS. When introduced in joints of rats with recurrent streptococcal cell wall–induced arthritis, the IL-10 transgene was induced in parallel with disease recurrence and effectively prevented the influx of inflammatory cells and the associated swelling of the joints. Levels of inflammation-inducible hIL-10 protein within the joints correlated closely with the severity of recurrence. An endogenously regulated therapeutic transgene can thus establish negative feedback and restore homeostasis in vivo while minimizing host exposure to the recombinant drug.
A.V. Miagkov, A.W. Varley, R.S. Munford, S.S. Makarov
Dominant mutations in sarcomere protein genes cause hypertrophic cardiomyopathy, an inherited human disorder with increased ventricular wall thickness, myocyte hypertrophy, and disarray. To understand the early consequences of mutant sarcomere proteins, we have studied mice (designated αMHC403/+) bearing an Arg403Gln missense mutation in the α cardiac myosin heavy chain. We demonstrate that Ca2+ is reduced in the sarcoplasmic reticulum of αMHC403/+ mice, and levels of the sarcoplasmic reticulum Ca2+-binding protein calsequestrin are diminished in advance of changes in cardiac histology or morphology. Further evidence for dysregulation of sarcoplasmic reticulum Ca2+ in these animals is seen in their decreased expression of the ryanodine receptor Ca2+-release channel and its associated membrane proteins and in an increase in ryanodine receptor phosphorylation. Early administration of the L-type Ca2+ channel inhibitor diltiazem restores normal levels of these sarcoplasmic reticular proteins and prevents the development of pathology in αMHC403/+ mice. We conclude that disruption of sarcoplasmic reticulum Ca2+ homeostasis is an important early event in the pathogenesis of this disorder and suggest that the use of Ca2+ channel blockers in advance of established clinical disease could prevent hypertrophic cardiomyopathy caused by sarcomere protein gene mutations.
Christopher Semsarian, Imran Ahmad, Michael Giewat, Dimitrios Georgakopoulos, Joachim P. Schmitt, Bradley K. McConnell, Steven Reiken, Ulrike Mende, Andrew R. Marks, David A. Kass, Christine E. Seidman, J.G. Seidman


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"You're guide to eating and living fabulously!"
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Whether it's some cute kitchen gadget or something really unique, I've tried to find the best and show them to you here! Take a gander and add some unique flair to your kitchen.
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Washington (CNN) - Rising GOP presidential candidate Herman Cain turned Sarah Palin's words against her Wednesday, saying he's unconcerned about a potential White House bid by the former Alaska governor as she'd be the "flavor of the week."
"The thing about Cain supporters is we build, and then we build, and we build," Cain said Wednesday at a book signing in Florida. "They don't defect. My supporters aren't going to run to the flavor of the week."
Palin previously knocked Cain's recent surge in the polls, casting him as the "flavor of the week" after he won a much-watched Florida straw poll nearly two weeks ago.
But this isn't the first time Cain, former CEO of Godfather's Pizza, showed his pique at Palin's ice cream analogy.
In an appearance on "The Tonight Show with Jay Leno," Cain joked Friday that his "flavor" was Haagan-Daas Black Walnut.
"Substance, that's the difference. I got the substance," Cain told Leno. "I'm the Black Walnut. It lasts longer than a week."
According to recent national polls, Cain has jumped to top-tier status in the 2012 GOP presidential race, joining former Massachusetts Gov. Mitt Romney and Texas Gov. Rick Perry.
Palin has said she's still considering a run but faces an Oct. 28 filing deadline for the first-in-the-nation primary in New Hampshire.
"What happens if Sarah Palin gets in? Well, if Sarah Palin gets in, we got one more person in the race. That's all there is to it," Cain said Wednesday.
Also see:
State of the Race without Christie
Romney comes out swinging in Sunshine State
Longtime Illinois Rep. to step down in 2012
Week? They've BOTH long since passed up their respective 15 minutes' worth of fame.
I don't think I can take another 18 months of this stuck on stupid politics...
Wait, wait, ................what's the flavor of the week? Vanilla? Chocolate? Mixed Nuts? All of the above????
what's the flavor of the week? Vanilla? Chocolate? Mixed Nuts?
Thomas I love your comment!
Palin has QUIT again..... Old habits die hard..
I LIKE this guy!!! He isn't afraid to call it like he sees it. And he actually seems to have his head on straight, and embraces the American values that made this country great. In fact, he embodies the American dream. THAT'S the kind of president we need in the White House!
No thanks! Cain is an idiot and an Uncle Tom who has no shot at the nomination. We don't need him or any of the GOP wackos shoving their "values" down our throats. Cain is NOT the kind of president we need in the White House and thank goodness this looney tunes never will sit in the Oval Office.
All Republicans are out of touch with reality. They sell us out to support the 1% They suck
"Oh, and Ron Paul. Regardless of your affiliation, it's WRONG that the mainstream media continues to neglect someone with his numbers."
Ron Paul is at the bottom of the barrel and has no chance of winning the nomination. Why should the media spend any serious time covering him? Besides, he's nuts!
GM is not sucess story. It is where the share holders were striped of their dollors by obama and given to the unions. That is not sucess. It is corruption at its finest. The Goverment has no right or authority to do such a thing. It's the obama dictatorship thing in motion. 2012 will get rid of many tax and spend rino's and democrats.
Cain is obnoxious and boring!!!
►TRENDING: Cain: Not rich? No job? Blame yourself◄
TRENDING: Me: Too Rich? No Creation of Jobs? Blame yourself!!!
Excuuuuuuuuuse me. The quitter was on Greta's faux news comedy show just last week praising "herb" cain. Now a week later she is throwing him under the bus?
Did she finally realize that the herb cain she was congratulating is really herman cain? I am sure she didn't read it in any newspaper so somebody had to tell her that she made another boob remark. Which reminds me . . . . . see those ta tas? Those are the real ones not the inflated ones shown on that other picture that cnn can't get enough of and some men think are real.
Both of them make me want to throw up in my mouth... neither would be a flavor of choice. Say it ain't so is all I can say, say it ain't so... he is so arrogant and full of himself, and she doesn't have a clue... neither one of these clowns in the white house.
Anyone who has had kids around 6-8 years old has seen this before. Just not from grown adults pretending to be presidential material.
Cain–You just lost my vote–Go back in yoiur box and come out when you can be civil–
OK, there's Cain. Now we need to find someone able. Oh, we already have him! Obama!
Has Sarah Palin ever been anything but "flavor of the week"? And I hope you like vanilla!
Corporate America's expansion into China was paid for by the American taxpayer. Bush's "tax cuts for the rich" policy helped to fund this transition. That's why no American jobs were created but a lot of Chinese jobs were. Republican politicians represent the corporate rich, the 'job creators'. When was the last time you saw a job created in the U.S.? The rich don't pay tax in this country and their corporations are physically based in communist China; where, by the way, SOCIALIZED healthcare and SOCIALIZED education are the norm. Republican politicians sold us (U.S.) out.
If Palin were a flavor of the week, it would be white on Rice.
enjoy the moment Herm, it won't be long before they turn on you.....
Cain better be careful because Palin thinks she is the "Savior of the Week." He would have to almost kiss her feet to get her endorsement. But maybe he would better if he doesn't because Palin is Poison!!
Mr. Cain enjoy your moment now because you will not win the Republican Primary.
You got that right Palin is a money grabbing, quitter gov, , un American, hateful person.
I like Mr. Cain...he is a well accomplished man with great ideas – but he just doesn't have what he needs (the political experience) to govern this nation.
But given the history of problematic issues our country has faced since its founding, it doesn't appear that anyone has what's needed to run our government.
Herb Cain has no money. He can't raise any money. What campaign?


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Please select the lenses you would like to add to your Buster frame
Prescription type
- Frame only
- Single vision+ £77.00
- Progressive+ £167.00
Lens type
Includes anti-reflection coating
- Standard lens
- High index+£40.00
Add to basket
This UK classic was the flagship model of the 1950s; probably the most popular model that many men chose to wear if they had the extra cash to splash out for a 'private' frame rather than the NHS freebie. It is a solid 'Library' frame and is comfortable to wear.
A solid, strong square shape with a thicker upper rim.
Suits: Medium to large faces.
Fitting notes: A medium to large library frame with a slightly narrower bridge fit, which enables the frame to sit higher on the face.
for 'distance' or 'reading'
for all distances combined
standard thickness
incl. anti-reflection coating
thin lens
incl. anti-reflection coating
Please select the lenses you would like to add to your Buster frame
Includes anti-reflection coating
Eye 52 / Bridge 22 / Temple 150
High quality cellulose acetate & German OBE hinges
Carry case and cleaning cloth included


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GROHE 122482 Minta L-Spout Kitchen Tap & FOSTER KE 34/18 Undermount Sink Bowl, Right Hand Bowl
Product Code 122482
Product Code 122482
GROHE 122482 Minta L Spout Kitchen Tap and Foster KE 34/18 Undermount Sink Bowl
Crafted with an L-shaped spout, this GROHE Minta Kitchen tap comes in a better design combined with a variety of convenient features for maximum flexibility in your kitchen. Its adjustable swivel range can be set at 0 degree, 150 degrees or 360 degrees, allowing you to either lock the spout in position or have it swivel, for instance when using two basins. With the high spout, filling large pots is easier than ever.
As for the kitchen sink, the Foster KE undermount is a design concept for installation under the worktop. Using brushed stainless steel with a durable 1 mm thickness, the design of the undermount provides a strong feature which is also easy to clean. The KE undermount sinks are fitted with a preventative sink overflow function that effectively acts as a safety solution. Available in both right-hand and reversible options in a variety of sizes, the undermount is designed to be a versatile option for your kitchen.
GROHE StarLight
Made-to-last surfaces ranging from precious matte to shiny like a diamond.
GROHE products are designed to look as beautiful decades on as they did the day you first fell in love with them. The special recipe to success lies in the long-lasting surface quality: GROHE StarLight Technology. Continuous improvement over the last 75 years has seen the unique plating process refined to produce a robust and immaculate surface that has been recognised as one of the best finishes in the world. This is thanks to rigorous quality controls and ongoing investment.
Smooth Turn
With its flexible swivel spout, this faucet provides maximum comfort with minimal effort. This feature is especially convenient when switching between two basins or working around to all part of the sink.
GROHE Comfort Height
Easy cleaning of big pots!
With this high spout, your GROHE faucet will master any challenge in the kitchen. GROHE products are suited to your needs and all the requirement of your home - for your comfort
GROHE Silkmove®
Only GROHE products deliver the GROHE Silkmove® experience.
The rich, smooth handling of the mixers expresses the quality of the brand. The GROHE Silkmove cartridge delivers gradual and precise control of the water flow and temperature.
GROHE BlueCore Components
The distinctive blue-coloured components at the heart of GROHE products give visual recognition to the uniquely-developed technologies in GROHE products.
BlueCore by GROHE sets apart the technology at the heart of their mixers, thermostats and water technology systems. BlueCore denotes utmost precision and outstanding ease of use.
Exceptional Quality & Design
German engineering and design go hand in hand to offer outstanding quality and performance.
Ongoing investment in research and development has enabled GROHE to turn world-leading technologies for bathrooms and kitchens into reality. Our products have been created to last a lifetime, to be both easy and intuitive to operate and to make the use of water a pleasure.
Foster High Quality Steel
Foster takes great care to use materials that provide performance.
The entire range is made with AISI 304 18/10 austentic steels. Thanks to the high percentages of chrome and nickel they contain, they give a bright finish and make products sturdy and resistant to rust and corrosion
Grohe 5 Year Guarantee
Grohe provides a 5 year guarantee to ensuring the products give you complete peace of mind.
High quality components ensure they are made to the highest quality and in the unlikely circumstance that a problem arises in the material, design, manufacture or functionality, you can rest assured that Grohe will replace the defected part or a complete replacement at there discretion


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How Can You Tell If Your City is Bikeable? Hint: Count the Women.
Image via: rlsycle on Flickr.com
What does it take to make a city bike friendly? Bike lanes? Isolated bike lanes? More bikes than cars? All of the above? In a recent article by Scientific American, the indicator species for determining how bikeable a city is is...women, and particularly the number of women on bikes. In European cities, male to female biking ratios are nearly equal, so why are men two times more likely to hop on a bike?One reason the article, "How to Get More Bicyclists on the Road" notes is that women are more risk averse than men, which is something that came up when talking with Luna Chix rider Karen Rehder on why it's so important to have women-only mountain biking classes. Thus, cities that are set up with bike-friendly infrastructure are more inviting to women, and cautious bikers in general. According to the study, women are more likely to veer from the shortest route in order to access bike lanes that are separate from roadways.
Okay, so to get the masses biking, you need infrastructure (bike lanes, for example), but you also need lanes that go someplace. If women do most of the errands, then they want bike paths and lanes that take them where they need to go. Creating bike lanes that go through parks and wooded areas, while nice and peaceful, are not particularly helpful to the mother with the baby strapped to her bike hoping to hit the post office and supermarket before dark. Plus, just from a safety aspect, sending bike lanes into areas that are dark and wooded will keep women off bikes and in cars.
Urban planners are now realizing that in order to get more people on bikes, they need to discover what seems practical to women and implement that. Some cities are implementing programs that specifically target women's fears, thus making them not a problem anymore. Women on Bikes, in Portland, OR, helps women fix flat tires, and New York City just installed 5 miles of separated bike lanes.
EcoVelo also chimed in on the idea with a few personal anecdotes about women on bikes. Each has a tale about what it took to get them on two wheels, and comfortable. One even reports on a Dutch woman who moved to the US and no longer bikes. Bummer. Hopefully that won't be the case for much longer. :Scientific American
More on Women and Biking
Does a Woman on a Bike Need a Weapon?
Women's Bicycle Racing Takes Off in Portland
6 Reasons The World Needs More Girls on Bikes
Bike Belles: Sustrans Raises its Voice for Female Cycle Safety


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About the DXC Dandelion Program
The DXC Dandelion Program
First piloted in Adelaide in 2014, the DXC Dandelion Program is an initiative designed to build valuable information technology skills and careers for individuals on the autism spectrum. Combining the use of robotics with commercial IT industry teaching and methodology, the focus of the program is on building and developing technical, life and executive functioning skills.
People with autism have long been overlooked in the workplace. Over 80% of people with autism are unemployed or under-employed. About 1% of the world has autism. Nearly half of those diagnosed with autism have above-average intelligence. In addition, some people with autism possess skills such as excellent visual perception, as well as the ability to remain highly focused in certain situations, which make them excellent candidates for certain businesses and roles.
The DXC Dandelion Program hopes to reach that large population of potential employees and harness their skills, while providing a holistic employment experience that prepares them for future careers within the technology field. The Program is designed to provide high levels of support to employees, both from a technical and autism perspective, and to ensure that they are able to learn and grow as employees and as individuals.
The DXC Dandelion Program is not just about recruiting people with autism. The Program is reworking the organisational fabric of DXC to accept and integrate these individuals, and to prepare them for the workplace and for a career in information technology. By successfully integrating people with autism into the workforce, organisations can achieve the competitive advantage found with a neurodiverse workforce.
The DXC Dandelion program is also part of a research program being undertaken with the Olga Tennison Autism Research Centre at La Trobe University.
A defining feature of the DXC Dandelion Program is the 'pod' structure used to manage DXC Dandelion teams on customer sites. Having this support structure in place allows for efficient management of the autism related needs of the DXC Dandelion team members. Below is an example model that has been tailored for a team in a testing role.
A diagram of a typical pod structure.
Support structure.
Three Year Progam Structure
The DXC Dandelion Program Plan is a three year structured roadmap of transformation initiatives based on business and IT priorities, effort, and learnings. It is intended as a plan of attack to improve the comfort and abilities of DXC Dandelion pod members in a number of key areas. This structure integrates feedback from the trainees, autism spectrum consultants, support employees, and evidence based research. Work experience programs are held to create a talent pool that can be drawn upon for DXC Dandelion pod positions.
Scale and Growth
Since the launch of the program, DXC Dandelion pods are now present on a number of customer sites across Australia, performing work in areas such as testing, analytics, IT operations, and cyber security.
Click here to learn more about what's involved in the program
Click here for the DXC Dandelion Program 2016 Year in Review
Click here for the DXC Dandelion Program 2017 Year in Review
Click here for the DXC Dandelion Program 2018 Year in Review
Contact Us
For further information about the DXC Dandelion Program, email us at firstname.lastname@example.com.


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Help us to support others – donate now and change a lifeDonate now
October 07, 2016
Our fundraiser of the week is long-time Action for M.E. supporter Margaret Nightingale.
Margaret and her husband Brian have been fundraising and supporting Action for M.E. for almost 15 years now and talking to her never fails to put a smile on our fundraising team's faces. Margaret has a stall in her local market every Friday where she sells knitting donated by our supporters. We've been told crafts and hobbies like knitting can be a good outlet for people with M.E., and some of our supporters even say they find it a useful restorative therapy.
Margaret is always looking for new items to sell, in particular toys, blankets and children's cardigans. If you would like to send something please contact the fundraising team at firstname.lastname@example.com.
© 2020 Action for M.E. Charity registered
in England and Wales: 1036419.
Registered in Scotland: SC040452.
Get in touch
Our office is open Monday to Friday 9am to 5pm. Please call our Information and Support Officers on 0117 927 9551 or send an email. You can also contact each team by direct dial.
Site Designed and Developed by Bake and Headadvisory.


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Laborer Level 2 - 9628735
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Laborer Level 2
Follow all safety rules. (Condition of employment) .
Always look for possible hazards and take action.
Know the appropriate PPE for the task and its proper donning and removal .
clean equipment, actessories, cords, etc
Move materials and equipment. Organize storage space and trucks.
Wipe, vac, sand, wire brush, paint, wrap, bag; sweep, wash, etc. as directed.
Inspect ladders, harnesses, lanyards, extension cords.
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Assist Technicians, learn their job
Demonstrate the proper use of power tools safely ie,, grinders
Demonstrate knowledge sf all chemicals used. lE, Read MSDS and comply, proper use, mixing, labeling, storing, disposal and what to do if there is a spill.
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Demonstrate skill at building containments under direction of Technician.
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10-05-2016 #1
Anyone here converted a manual Bridgeport mill to CNC?
After building my plasma table and my mini-mill, both of which are working lovely, I WANT MORE CNC ;) ;)
My old 9x48 Bridgeport is looking for some love but is it worth it?
It would need a ball-screw conversion kit, these are available, plus I am guessing servo drives on X, Y and Z so I have encoder display, the knee doesn't seem to get driven on the few vids i have watched so far.
On the plus side, it's already powered via a VFD :D and i could likely recoup some cash by selling the working power feeds, control box and new DRO i fitted last year.
Worth a look or too expensive/not good enough...
10-05-2016 #2
Yes, done it to something similar.
has cost me around £3000 in total by now but only using steppers plus the cost of the machine. £1500 for the ballscrews as I went full hog with high preload and C3 accuracy. Also went with £300 worth of angular contact bearings to suit. Would have gone servo's if funds had allowed then.
Do not sell the DRO, I find it invaluable as you want to be able to switch between cnc and manual and also helps calibrate steps per unit.
From what I read the kit ballscrews are not as good as you are made to think, hence I went with my own ballscrews.
10-05-2016 #3
Don't bother.
Sell the manual and buy a dead CNC.
You have a machine that's currently worth about £900 ? you throw close to 2K at it and have a machine worth £800
Look for a BOSS 1 to 4 or an MDI machine. These were made as CNC, ballscrews, pressure oiling, a really nice quill where the ball screw is actually around the quill and not an add on that just wants to lever the quill sideways.
Downside of these machine which is in your favour is the electrics were crap, sorry make that $hit. Result is the iron is very good as ost have stood the last 15 years acting a shelf somewhere.
Beaver V5 here sold for £650
TOS CNC mill sold for £460 OK not working but that doesn't matter for a refit.
You could have got 1/2 of that back reselling the controller.John S -
10-05-2016 #4
I think you might be right there John, it's being in the right place at the right time to catch the machines when they pop up, plus getting some transport arranged.
Will keep looking.
12-05-2016 #5
Am I right in my belief that if i want real-time display of position in Mach3, I need to use servo's and encoders?
12-05-2016 #6
12-05-2016 #7
Hmm, just had a thought...
Instead of dropping around £2k on building a mini-mill/router, what I should have done is use that cash to convert the Bridgeport and fit an adaptor mount that enables me to hold the 24k water-cooled spindle - best of both worlds??
I could even mount a complete Z-axis on the rear of the ram where the slotting head should fit!
The BP has a lovely 48" bed, ok maybe it only has 9" of Y axis but thats still not too shabby I think, certainly I've done a hell of a lot of big jobs on the old girl.
So, what would the drawbacks be here?
The new spindle has the speed I need, I think a BP conversion can reach 4-5000 mm/min rapids which is where the mini-mill is set so thats no issue, ballscrews would provide the same accuracy as the mini-mill has presumably.
Last edited by Davek0974; 12-05-2016 at 02:27 PM.
12-05-2016 #8
You lose Z travel when you convert the bridgeport's quill and another bit more when you add the adapter to hold the high speed spindle. Apart from that, I cannot see any issues except the speed at which your motors are able to move the bed. Good lubrication is key here. 4-5000 is way to quick for stepper conversions but possible with good servos. I have restriced mine to 3000mm/min actually.
Last edited by komatias; 12-05-2016 at 02:34 PM.
12-05-2016 #9
Ok, but by building a custom Z-axis and mounting it on the rear of the ram I would retain whatever travel I build into the new axis, it means swivelling the ram round to change from heavy to light milling but thats about it, plus would need two z-axis drives - heavy and light.
The Z on the heavy side is a pain, a couple that i have seen today - one replaced the quill lever with a toothed pulley and drove that via a planetary gearbox reduction - seemed ok, another replaced the fine-feed hand wheel and drove that, the ones that mount to the front of the quill I am not too impressed with, have read a few tales of quills being trashed by the single bolt pulling out.
As for speed, so far most of my mini-mill work ranges from 600mm/min to 150mm/min - hardly blistering, I'm sure the old girl can match that ;)
I think this may be an interesting project.
12-05-2016 #10
Yes, that would do it. I have gone with direct drive on the quill and do not over drive it. The fine feed goes through a clutch while the backlash on the lever is too much for CNC.
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Monday, May 12, 2014, 1:00 pm - 2:00 pm
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Andrew Mead reviews an exhibition focusing on 'The last Imaginary Place', looking at the Arctic as a place of architecture and habitation
There is a book about the Arctic with a very apt title, The Last Imaginary Place. Its archaeologist author Robert McGhee surveys years of progressive enlightenment about the region, as facts replace fantasies and science supplants the imagination. Faced with this proliferating information, McGhee asks: 'Do knowledge and clear vision compensate for the loss of the imaginary world, or is it possible for the two levels of perception to coexist?' He decides they can.
This interplay of the factual and the imaginary is at the heart of a big exhibition at the Louisiana Museum, which focuses on the last two centuries − a period in which the Arctic was first an ideal realm for artists, a site of sublime landscapes, but is now ripe for exploitation, as recent Greenpeace protests over oil drilling have highlighted. In the process it reminds us that the region is not just a place of inhuman ice and snow but of architecture and habitation, whether in longstanding coastal settlements in Greenland, industrial towns in Siberia, or widespread US military installations from the Cold War. If the exhibition prompts more trains of thought than it pursues, that's perhaps inevitable with so resonant a subject.
The blurb says excitedly that the show is about 'dreams, destiny, adventure and beauty … a tale of fear, fascination, desire, downfall', but it begins rather dourly with photographs taken in 2003 by Darren Almond − near monochromes in shades of grey and white in which the horizon almost vanishes and the landscape is a source of bleakness not beauty. They make an effective contrast with what lies beyond: the Arctic in the visions of 19th-century artists, presented as reproductions in huge freestanding light-boxes. Of course these paintings were fictions, contrived in the studio, and the show puts them in context by including smaller versions of works by Caspar David Friedrich, Turner et al, which equally aspired to the sublime.
As knowledge about the Arctic increased, the awe, fear and beauty of the sublime were displaced by data. In an alluring group of antique maps we see the shift from the voids and speculations of Renaissance cartographers to the precise plotting of mineral deposits in geological surveys of Greenland. This map-making comes right up-to-date with the work of ScanLAB, which creates digital models of ice floes − the results resemble space probe images of distant planets.
Ironically, the names most readily associated with the Arctic are not of people who have discovered most about it but who instead have been in quest of the North Pole. The exhibition takes a sceptical view of such 'heroism', but there is rich visual material on one of these adventurers, Fridtjof Nansen, in some engaging vintage photos − for instance, Nansen ruminatively smoking a pipe in front of his ship, the Fram, which was trapped in ice for two years.
Eventually the ice broke up and released the Fram from its grip, but today it seems that the ice is disintegrating more generally. The show's line on climate change is neatly summed up in one caption: 'There is a widespread consensus that global warming exists and has been man-made over the last 200 years. Disagreement concerns what the effects of these changes will be.'
Taking a long view of fluctuations in climate, one exhibit features the remains of a forest discovered well above the current tree-line in northern Greenland − it's thought to date from a warm inter-glacial period some 2 million years ago. But the impact on the region's residents of any future change is not examined. What we find instead in the section on habitation are 19th-century watercolours of a Greenland village with its church and seminary, and photographs of the Siberian town of Tiksi − a military and scientific base now largely abandoned with the end of government funding.
There is some intriguing material on US military infrastructure in the Arctic, including a gung-ho propaganda film on the creation of Camp Century, a nuclear-powered research station beneath the Greenland ice cap. But while a special Greenland issue of Arkitektens Forlag (2012:4) is on sale in Louisiana's bookshop, the show itself gives little sense of today's townscape and architecture. This seems like a real omission, given the excellent photos by Olaf Otto Becker and Joël Tettamanti that could readily fill the gap.
Punctuating the exhibition are works by contemporary artists, who the curators say are taking a renewed interest in the Arctic after decades of indifference. Ellie Ga spent five months as the only artist on a scientific exhibition in the Arctic Ocean, but judging from her Drift Drawings − meagre both aesthetically and intellectually − she hardly made the most of her time.
Other works have more to offer: Jacob Kirkegaard's eerie Icefall, surrounding you in a darkened room with the sounds of a melting glacier; a hypnotic video by Sophie Calle, shot from a ship slowly steering past gleaming icebergs; and more icebergs, with fantastic profiles, in a photograph by Per Bak Jensen. Clearly the sublime can still be found in the Arctic, not least in a time-lapse sequence of the Northern Lights, which proves that nature can still upstage Hollywood when it comes to special effects.
Less elegant than it could be, the catalogue reproduces many of the works and contains some worthwhile texts, including one by Peter Davidson, whose fine book The Idea of North has much in common with The Last Imaginary Place. 'The north has always been a place of marvels and wonders, of which the first, perhaps, is ice itself … Greenland is powerful as an idea, one of the most powerful ideas of north. Even to Scandinavians, it was the true ultima Thule,' writes Davidson.
But recent months have seen not just Greenpeace protests about oil drilling but the announcement that a UK company, London Mining, is about to create a vast open-cast iron ore mine in Greenland − 'the largest commercial project in the country's history'. Perhaps Almond's bleak photographs at the start of the show are prescient. Whether through climate change, mining, or just too much information, the Arctic of the imagination is precarious now and may soon lose its power to enchant.
Venue: Louisiana Museum
City: Humlebæk, Denmark
Dates: Until 2 February
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Published by ozpossum
A life long passion for colour, form and texture. Jewelry designer, wearable bead embroidery artist, pastel and acrylic painter, horticulturalist, casual gardener and lover of all dogs and wee creatures. Must be in contact with animals, birds, trees and gardens for general well being. (www.janebaridesign.com) View all posts by ozpossum


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Candidate Ridiculed for Momentarily Forgetting the Phrase 'Birth Control'
In his first debate with pro-choice Democrat Andrew Romanoff, Colorado Rep. Mike Coffman (R) tried to say he supports access to contraception after emphasizing his opposition to Colorado's "personhood" amendment, but he blanked momentarily as he tried to recall the words "birth control," drawing ridicule from Romanoff and pro-choice advocates.
In his first debate against his Democratic challenger Andrew Romanoff, Rep. Mike Coffman (R-CO) couldn't recall the phrase "birth control," leading pro-choice activists to assert, once again, that Coffman can't be trusted on women's health issues.
During the debate Thursday, the two candidates, battling in one of the most competitive U.S. House races in the country, were asked by moderator Aaron Harber to talk about their differences on "women's reproductive rights and healthcare."
Coffman started his response by saying he's "proud" of being "pro-life." Then he said, "I do not support personhood, but I support a woman's access to, to, um, certainly, certainly, to, ah, the Hobby Lobby decision, to, uh, to get –"
Murmurs began to be heard from the audience.
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"Birth control!" shouted Coffman, throwing his head into his arms on the table and thrusting the microphone at Romanoff, who said he neither supported the Hobby Lobby decision nor "personhood."
A spokesman for Coffman clarified Coffman's garbled answer, telling Denver's KDVR-TV that Coffman supports the recent Hobby Lobby decision as well as access to birth control.
Shortly after the debate, the Romanoff campaign shot off an email with the subject line, "Watch it Yourself" and a link to Coffman's brain freeze.
"If you weren't among the hundreds who packed into the Hilton Garden Inn in Highlands Ranch this morning," read the Romanoff email, "you missed a revealing exchange.
"In the first debate of this campaign, Andrew reaffirmed his support for women's rights, including our right to make our own health-care decisions. Mike Coffman, in contrast—well, watch it for yourself."
Coffman's pro-choice critics used Coffman's lapse to spotlight the Congressman's anti-choice positions, which have been a favorite target for Coffman's opponents this year.
"Not only does Mike Coffman not know how to say birth control, he doesn't know how to support access to it, either," said Karen Middleton of NARAL Pro-Choice Colorado in a statement blasted out to reporters immediately after the Coffman-Romanoff debate.
"Mike Coffman can't have it both ways," said Middleton. "You can't back the Hobby Lobby decision to put bosses in between women and their doctors and attempt to say you support birth control access for Colorado women too."
In March, Coffman rescinded his longstanding support for Colorado's failed "personhood" amendments, which would have banned all abortion, even for rape. He recently toured a stem-cell research lab, which relies on embryonic stem cells, despite his previous opposition to embryonic stem-cell research.
Coffman also said he now supports offering raped women the option of abortion, despite vehement opposition in the past to this exception to his anti-choice stance.
Coffman's new positions, which have drawn repeated fire from Romanoff, came after Coffman's congressional district, previously represented by Republican Tom Tancredo, was re-drawn in 2010, changing from safe Republican to competitive. President Barack Obama carried the district by five points in 2012, and women are widely seen as a key voting bloc.
Nonetheless, Coffman, who previously served in the Colorado legislature and as Colorado's treasurer and secretary of state, won re-election in 2012 by two percentage points over staunchly pro-choice Joe Miklosi.


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Abacus: Small Enough to Jail
2016, Steve James, USA, 88 min.
Show Times
- Fri, Aug 4th 2:00pm
- Fri, Aug 4th 6:00pm
- Fri, Aug 4th 7:45pm
- Sat, Aug 5th 3:00pm
- Sun, Aug 6th 5:00pm
- Mon, Aug 7th 6:00pm
- Tue, Aug 8th 8:00pm
- Wed, Aug 9th 6:00pm
- Thu, Aug 10th 8:00pm
★★★½ "A compelling and, even now, suspenseful nonfiction account." — Michael Phillips, Chicago Tribune
"As gripping as the movie is as a legal thriller, it's even more notable as a portrait of a community." — Matt Zoller Seitz, RogerEbert.com
How did Abacus, a small family-run bank, become targeted by the feds to take the fall for the 2008 financial crisis when the Wall Street giants tiptoed away so handily, asks award-winning filmmaker Steve James (HOOP DREAMS, THE INTERRUPTERS) in this affecting David vs. Goliath chronicle. Jimmy Stewart's George Bailey, banker hero of IT'S A WONDERFUL LIFE, served as the role model for New York Chinatown lawyer Thomas Sung when he founded a community-friendly bank in the 1950s, serving an insular, bank-shy immigrant population. In 2010, his staff discovered and reported irregularities perpetrated by one mortgage manager, bringing down the wrath of the Justice Department and making Abacus the sole bank to face federal charges in the wake of the financial crisis. Nineteen employees were led away in chains before TV cameras, and the resulting five-year media circus and show trial exposed suspiciously glaring inequities in the government case. DCP digital. (BS)
Friday, August 4 at 7:45 PM & Saturday, August 5 at 3:00 PM: Director Steve James will be present for audience discussion.
Play Trailer


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Question: How free is the internet? Answer: Less than free in certain countries. Further answer: And becoming even less free in other countries — witness Vietnam, discussed briefly below.
At the start of this month, a law went into effect in Vietnam that mandates removal of online content considered offensive to the Vietnamese government. According to SoyaCincau.com, the law was put on the books "under the pretenses" of Cybersecurity, but what it actually does is require the takedown of content deemed "toxic" by the government.
Continue reading Internet Companies Must Take Down Anti-Government Content in Vietnam