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James L. Dolan Music Recording Studio
The brand new James Dolan Music Recording Studio is a 7,500 square foot multifunctional teaching, recording, and research space designed by Gensler and the Walters-Storyk Design Group. One of the most technologically advanced audio teaching facilities in the United States, the new facility greatly enhances the existing 12 studios which house the Music Technology program of NYU's Steinhardt School of Culture, Education, and Human Development. The studio is located on the sixth floor of 35 West 4th Street.
The new complex is distinguished by a 25-seat control/classroom which features a fully automated 48 channel SSL console and the first Dangerous Music 10.2 surround installation in New York City. In addition to a live room large enough to accommodate a small orchestra, the floor includes several research laboratories, offices, a conference/seminar room and a large iso/drum booth. Multiple windows and a full line of sight provide natural light throughout.
A unique research lab dedicated to 3D audio experimentation is equipped with an innovative, reconfigurable grid outfitted with sixteen Genelec speakers, two Genelec subs and multi-channel micing, tracking and playback options. The lab also boasts extremely low (.2 second) reverb time.
Since its opening, the new studio has been featured in many online publications. Below is a partial list of press coverage.


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August 2010 Mystery Dishcloth Knit Along Reminder!
Click HERE for all the upcoming KAL details
Everyone is more than welcome to join and knit along with us!
Hope all is well with everyone.
Take care.
Where you can find me:
Follow Me On Twitter:
Knits by Rachel:
Rachel's Knitting Corner:

subset: commoncrawl


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Loong begins official launch
Free-to-play martial arts MMO Loong: Power of the Dragon has officially launched today, after a week's delay from its previous launch date of January 12th.
The launch means that all previous beta information was wiped from the servers. Closed and open beta testers will be able to collect rewards from the Treasure part of their bags for their participation, and the first day also features boosted experience.
Loong is published by Gamigo, which also publishes King of Kings 3 and Cultures Online.
Loong Gameplay Screenshot
Dear Loongarians,
we are live! Come in, make yourself at home, and explore our world without any boundaries!
The server was successfully wiped and we performed important improvements on the server stability and capacity.
Patch Note 18.104.22.168
Improved localization
Fixed problematic auto-paths
Fixed log on and off screens
Dragon Market
The Dragon Market will be updated tomorrow.
Everyone who participated in the Dragon Market bonus should have received all their Ingots.
CBT and OBT Rewards
Please check your "Treasure" tab in your Bags to find your first rewards for having helped us these past weeks. Another, more visual, reward will be given out once ready.
To all new players
Remember to accept ALL quests in the first area. Specifically the one that reads: "Leaving the Village"
Skipping this quest will seal you permanently in the tutorial area.
And remember to join our wonderful community in our Forums – you will need to create an account on the Forums to see all sections.
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Patent application title: METHOD AND APPARATUS FOR COLLECTION OF PROTOCOL ADHERENCE DATA
Adam Hanina (New York, NY, US)
Gordon Kessler (Mt. Kisco, NY, US)
Gordon Kessler (Mt. Kisco, NY, US)
IPC8 Class: AG06Q5000FI
USPC Class:
705 2
Class name: Data processing: financial, business practice, management, or cost/price determination automated electrical financial or business practice or management arrangement health care management (e.g., record management, icda billing)
Publication date: 2011-09-22
Patent application number: 20110231202
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A data capture and storage apparatus for use in confirming administration
of medication in a clinical trial or other medication administration
scenario is provided. The apparatus includes a data capture device for
capturing one or more types of data related to administration of a
medication, a storage device for storing the captured data and a
processor for processing the stored captured data. The processor further
includes an analysis element for performing a local analysis of the
stored captured data. The processor is further adapted to identify a
particular medication prescription regimen in accordance with the
clinical trial or medication administration scenario, determine one or
more procedures for administering such prescription regimen, identify one
or more activity sequences associated with such procedures, capture
activity sequences of actual administration of such prescription regimen
compare the captured activity sequences to the identified activity
sequences to determine differences therebetween, and providing a notice
if differences are determined.
1. A data capture and storage apparatus, comprising: a data capture
device for capturing one or more types of data related to patient
behavior; a storage device for storing the captured data; a processor for
processing the stored captured data, the processor further comprising an
analysis element for performing a local analysis of the stored captured
2. The apparatus of claim 1, further comprising a transmission system for transmitting captured data to a remote storage and analysis location.
3. The apparatus of claim 2, wherein the local analysis determines whether an immediate response to a patient would be proper.
4. The apparatus of claim 2, wherein the remote storage and analysis location determines whether a supplemental response to a patient would be proper.
5. The apparatus of claim 4, wherein the supplemental response is transmitted from the remote storage and analysis location to the data capture and storage device.
6. The apparatus of claim 1, further comprising: a display for displaying various information to a user; a transmission system for transmitting information to a remote storage and analysis location; and a receipt system for receiving information from the remote storage and analysis location.
7. The apparatus of claim 1, wherein the patient behavior comprises an activity associated with administration of a prescription protocol.
8. A data capture and storage apparatus for use in confirming administration of medication in a clinical trial, comprising: a data capture device for capturing one or more types of data related to administration of a medication; a storage device for storing the captured data; a processor for processing the stored captured data, the processor further comprising an analysis element for performing a local analysis of the stored captured data, the processor adapted to perform the steps of: identifying a particular medication prescription regimen in accordance with the clinical trial; determining one or more procedures for administering such prescription regimen in accordance with the clinical trial; identifying one or more activity sequences associated with such procedures; capturing activity sequences of actual administration of such prescription regimen by the data capture device; comparing the captured activity sequences to the identified activity sequences to determine differences therebetween; and providing a notice if differences are determined.
9. The apparatus of claim 8, wherein the prescription regimen is provided by a clinical trial manager.
10. The apparatus of claim 8, wherein the prescription regimen and procedures for administering the prescription are retrieved from a medical database.
11. The apparatus of claim 8, further comprising a transmission and reception system for transmitting data to, and receiving information from, a remote storage and analysis location, the remote storage and analysis location being adapted to perform a statistical analysis of differences determined in the comparison of the captured data.
12. The apparatus of claim 8, the processor further: retrieving medical history information of a patient to receive the administered medication subject to the clinical trial; and confirming that a to be administered medication is safe for the patient; wherein a warning is issued by the data capture device if it is determined that the to be administered medication is not safe for the patient.
13. The apparatus of claim 8, wherein the data capture and storage device provides additional instructions to a medication administrator in accordance with the notice.
14. The apparatus of claim 8, wherein the data capture and storage device provides live contact with a clinical trial manager.
15. The apparatus of claim 8, wherein the notice comprises additional instructions to a patient receiving the medication according to the one or more procedures of the clinical trial.
16. A system for confirming administration of medication, comprising: an authentication apparatus for authenticating a medication manager; a database comprising prescription administration information for the medication; a data capture and storage device for receiving information identifying a particular medication prescription regimen from the authenticated medication manager, for storing prescription administration information selected from the database and being associated with the identified medication prescription, a set of instructions in accordance with which the prescription regimen is to be administered, and one or more activity sequences associated with such instructions, for capturing activity sequences of actual administration of such prescription regimen over a plurality of administrations of the prescription regimen, for comparing the captured activity sequences to the identified activity sequences to determine differences therebetween; for providing an immediate notice if differences are determined in the comparing step that may place a patient receiving the prescription regimen in danger; and for providing a notice if differences are determined in the comparing step that may improve future administration of the prescription regimen in the clinical trial;
[0001] This invention relates generally to patient compliance in clinical drug trials or other medication administration protocol scenarios, and more particularly to an apparatus for the collection, analysis and transmission of data related to monitoring, instruction and intervention of patients in clinical trials or other medication administration protocol scenarios in order to improve adherence with prescribed drug protocols in accordance therewith.
[0002] Dr Lars Osterberg, M.D. and Dr. Terence Blaschke have reported in the New England Journal of Medicine, Adherence to Medication, (N Engl J Med 2005; 353:487-97) 2005 an alarming lack of adherence to required medication protocol, further noting that while the average rates of adherence in clinical trials is categorized as "high", this number still comprises only rates of 43 to 78 percent. Most importantly, the authors note "The ability of physicians to recognize nonadherence is poor, and interventions to improve adherence have had mixed results." Adherence, p. 487. The authors conclude "Poor adherence to medication regimens is common, contributing to substantial worsening of disease, death and increased healthcare costs." Adherence, p. 494. The Trend Repot Series, 2008 Patient Adherence Update: New Approaches for Success, October 2008, report similar discouraging statistics. This broad range may possibly contribute to the public confidence in the FDA approval process and the importance of continued surveillance of a drug throughout the process. Furthermore, it may help to explain why, according to the Journal of the American Medical Association (JAMA May 1, 2002), one out of every five new drugs that comes to market in the US is found to have serious or life-threatening adverse effects--unknown or undisclosed at the time of approval. It is against this backdrop of poor adherence, and potential danger to patients, that the present invention operates.
[0003] It has been widely recognized that methods and systems for insuring proper medication ingestion or administration by individuals are very important in defending against unnecessary sickness, deaths and other problems. Giving instructions and then letting patients fend for themselves has been shown not to work particularly well. This is because it is not only the improper ingestion of medicines that is the primary cause of medical danger. Rather, an overall lack of sufficient patient guidance is also part of the problem. Further, the inability to confirm a proper prescription regimen being provided to a user in the first place may cause a number of other problems with the use of such medication.
[0004] Traditionally, participants attend introductions and follow ups for clinical trials in-person. Other patients attempting to adhere to a particular medication protocol similarly are given a prescription and a particular set of instructions from a prescribing medical provided or prescribing doctor, and then compliance is measured at a next visit with that prescribing professional. Thus, data collection is similarly limited to patient visits, rather than on a daily basis. Old methods such as patient questioning and pill counting have been proven to be inadequate measures of adherence and offer no information on dose timing and drug holidays (omission of medication for three or more sequential days).
[0005] Compliance technologies can increase the statistical power of clinical trials. Through the use of such technology, clinical events can be precisely linked to medication use history. Captured data can be linked to other sources such as EDC, patient diaries and data collected by the physician. Technologies can create many possibilities for remote visits and data capture. While smart packaging technologies exist such as RFID-enabled computer chip technology, smart blister packs and MEMS caps (microprocessor in a bottle cap), they are: a) invasive and need to be physically attached to the medications; b) are non-conclusive regarding compliance--a patient may activate the technology without ingestion of the medication; c) remain largely unadopted in clinical trials by the pharmaceutical and biotech companies due to their high cost; and d) take a longer time to implement. Further, electronic patient diaries allow for ease of entry of data by a patient. These diaries, however, are still subject to issues related to compliance with medication adherence. Thus, even if a patient is meticulous about entering information into the diary, and thus complying with the requirements for data entry, there is still no guarantee that they are properly taking medication at prescribed times.
[0006] Jo Carol et al. stated that "The most reliable method for research purposes, although not practical in a clinical setting, may be a combination approach that includes pill counts, patient self-report, and electronic monitoring." (Carol J. et al, Patterns to Antiretroviral Medication, The Value of Electronic Monitoring, AIDS, 17 (12), pp 1, 763-767, October 2003. To date, technologies alone have only been used to monitor compliance rather than to encourage it. Furthermore, there has been no comprehensive system provided that allows for the management of multiple patients and multiple patient populations. While current technology may allow poor compliers to be recognized, as will be described below, the proposed apparatus and method of the present invention will help to encourage pharmaceutical compliance and tackle some of the problems that are encountered in the clinical trial process in particular, and the medication protocol monitoring problem in general.
[0007] A number of systems exist that provide instructions to a user regarding when to take a medication and records when the user indicates that a medication has been taken. U.S. Pat. No. 7,359,214 describes such a system. A device is provided that provides instruction to a patient regarding medications to take. Furthermore, the system may provide a method for determining that the prescription is appropriate given the patient's conditions, and other medications he or she may already be taking The system may monitor the dispensing of medicine in accordance with a predetermined treatment protocol. While such a system provides many improvements for easing a burden on the patient, this system suffers in many ways and in particular in ways relevant to the administration of clinical trials and other active patient monitoring of medication adherence.
[0008] Most importantly, this system provides no mechanism for actually confirming that a patient is in fact ingesting or otherwise properly administering required medication as required in a clinical drug trial, or as prescribed by a prescribing physician in the case where adherence to a particular regimen may prove to be critical to efficacy of the prescription regimen. Further, while the system may be sufficient for one who is in full possession of their mental faculties, any individual who may have difficulty following directions, or one who is actively avoiding medication may still not be taking required medication after it is dispensed. Thus, participants may be forgetful, visually impaired, or otherwise do not believe in the benefit of taking such medication, and may thus not properly log medication administration. Furthermore, the system requires preloading of various medications into a dispenser, and thus likely requires regular visits by an administering manager to be sure appropriate medications are in fact properly loaded therein. It is surely possible that an inexperienced user may place incorrect medications into the device, or may somehow provide incorrect dosages into the device. Additionally, for potentially more complex regimens, there is no method provided for insuring that a user is able to follow such a protocol, and to thereafter confirm that the user has in fact taken all required medications in accordance with any provided instructions or the like, or has taken the medications according to one or more specifications or followed suggested procedures. Finally, this system is expensive and requires constant maintenance to confirm that the various mechanical parts are in working order.
[0009] U.S. patent application Ser. No. 11/839,723, filed Aug. 16, 2007, titled Mobile Wireless Medication Management System provides a medication management system employing mobile devices and an imaging technology so that a user is able to show a pill to be taken to the system, and the system can then identify the medication. Patient histories are available to an administrator, including various vital signs as measured by the system. Images may also be taken of the patient, provider, medication container or the like. While the system professes to ensure adherence to a protocol, the system only provides such help if requested by a user. There is in fact no particular manner in which to ensure actual adherence or the relationship of adherence to the efficacy of the drug over time. When requiring adherence to a predetermined protocol for a clinical trial, this is particularly relevant.
[0010] Additionally, existing systems fail to maintain an audit trail for post administration review by a medical official or other clinical trial administrator, and further cannot therefore confirm confirmation of proper medication administration.
[0011] Therefore, it would be desirable to provide an apparatus that overcomes the drawbacks of the prior art.
[0012] In U.S. patent application Ser. No. 12/620,686, filed Nov. 18, 2009, titled Method and Apparatus for Verification of Medication Administration Adherence; currently pending, U.S. patent application Ser. No. 12/646,383, filed Dec. 23, 2009, titled Method and Apparatus for Verification of Clinical Trial Adherence, currently pending; and U.S. patent application Ser. No. 12/646,603, filed Dec. 23, 2009, titled Method and Apparatus for Management of Clinical Trials, currently pending, the contents of these three applications being incorporated herein by reference, the inventors of the present invention have proposed a system and method that allow for complete control and verification of adherence to a prescribed medication protocol or machine or apparatus use in a clinical trial setting, whether in a health care provider's care, or when self administered in a homecare situation by a patient.
[0013] These applications present the only medication management system that may determine whether a user is actually following a protocol, provide additional assistance to a user, starting with instructions, video instructions, and the like, and moving up to contact from a medication administrator if it is determined that the user would need such assistance in any medical adherence situation, including clinical trial settings, home care settings, healthcare administration locations, such as nursing homes, clinics, hospitals and the like, and in clinical trial settings.
[0014] In accordance with the present invention, an apparatus is provided that facilitates information presentation to a patient, information capture of medication administration at home in a homecare setting, in a hospital setting, in a clinical trial setting, or in any other setting in which medication adherence is potentially an issue, and other aspects described as part of the method and system of the pending applications noted above. Therefore, in accordance with the present invention, a video capture device is provided including a memory for storing captured video and other patient data, analyzing such captured data, transmitting such captured data to a remote location, receiving information from a remote location and providing information to the patient as preferred in accordance with the present invention. In accordance with a preferred embodiment of the invention, an apparatus is provided comprising a video capture device, an audio capture device, memory for storing such captured data, a processor adapted to operate analysis software for analyzing the captured data, a transmitter for transmitting the captured data, or other versions of the data or analysis results to a remote location, for receiving data and further instructions or communication from the remote location, and a display for providing such data or further instructions to the patient. Such apparatus may preferably interface with management software adapted to manage multiple patients, and thereby providing a full monitoring and data collection procedure.
[0015] The novel combination of text, graphical, pictorial, and video presented in accordance with the present, and as further described in the above noted applications allows the compliance problem within clinical trials and other patient monitoring of adherence to medication protocols to be tackled in a holistic manner. The present invention provides an apparatus that presents a number of solutions. The apparatus preferably may provide step-by-step image and video instructions to the user or care provider on how to administer medication, what the side effects of the medication are and the benefits that have been found. This avoids misunderstandings resulting from prescribing instructions and may allow an approach that may be utilized internationally, thus overcoming possible language barrier issues and the like.
[0016] A specific medication regimen may be programmed into a medication calendar included within the apparatus constructed in accordance with the invention to alert the user when medication should be taken and provide clear video instruction for taking the medication. These reminders minimize forgetfulness by the subject in clinical trials or when administering medication in a typical home setting, and help the logistical challenges involved in complex medication regimen such as double blind studies, for example. Furthermore, the medication calendar and the compliance results are accessible to the clinical trial organizers.
[0017] Once an alert is provided by the apparatus of the invention and the patient has confirmed that they are ready to take the medication, the apparatus is adapted to record the type of medication and quantity through image recognition. The subject may show the medication to the imaging device of the inventive apparatus which then authenticates the medication if in the correct dosage and offer administration instructions. Other types of recognition of the bottles may also be used, including RFID tags, bar code reading, text recognition, or other confirmation through a provided graphical user interface, preferably in conjunction with the image recognition. Once the medication type and quantity has been authenticated, the apparatus if the invention records or otherwise visually analyzes the patient actually administering the medication to him or herself, using any of the above recognition methods, and further including facial recognition, badge identification, or any other method for confirming the identity of the individual. A real-time log for audit trails and further analysis is thereby created. Additional information may be captured using a brief questionnaire on the device which may help to highlight problems when administering the medication--such as difficulty in swallowing tablets or opening packages--or adverse reactions from which the patient is suffering. Whatever the reason a patient misses a reminder or medication prompt, the system and method of the invention alerts the clinical trial organizers. Data from all the population can be captured and presented in an aggregated manner online in real-time, giving real-time data results and flag problems or results early.
[0018] It is therefore contemplated that the apparatus in accordance with the present invention be applicable to settings including clinical trials, as well as in more general healthcare settings, such as with home care provided by a healthcare assistant, or self administered by a patient, in a hospital or other clinic setting, or in other locations where medication management would be beneficial. The ability for the apparatus constructed in accordance with the invention to capture patient and medication administration data in a more controlled environment will allow for more consistent data to be gathered, thus easing the burden of insuring adherence to one or more prescribed medication administration regimens.
[0019] Furthermore, while the apparatus constructed in accordance with the application has been described as implementing a method and system as described in one or more other pending US patent applications, it is intended that the apparatus be available as a standalone apparatus, for use and implementation in systems other than those described in accordance with this or other noted patent applications.
[0020] Still other objects and advantages of the invention will in part be obvious and will in part be apparent from the specification and drawings.
[0021] The invention accordingly comprises the several steps and the relation of one or more of such steps with respect to each of the others, and the apparatus embodying features of construction, combinations of elements and arrangement of parts that are adapted to affect such steps, all as exemplified in the following detailed disclosure, and the scope of the invention will be indicated in the claims.
[0022] For a more complete understanding of the invention, reference is made to the following description and accompanying drawings, in which:
[0023] FIG. 1 is a block diagram depicting an embodiment of the invention;
[0024] FIG. 2 is a block diagram depicting details of systems associated with an embodiment of the invention;
[0025] FIG. 3 is a flow chart diagram depicting a method in accordance with an embodiment of the invention; and
[0026] FIG. 4 is a flow chart diagram depicting a method in accordance with an embodiment of the invention.
[0027] Referring first to FIG. 1, a remote information capture apparatus 100 is shown. Such apparatus is adapted to allow for the capture and processing of information in order to implement the system and method in accordance with the applications noted above and incorporated herein by reference. Such information capture apparatus 100 is placed in communication with a remote data and computing location 300 via a communication system 200, preferably the Internet or other communication system. Via communication system 200, information captured by apparatus 100 is transmitted to remote data and computing location 300, and analysis information or other instructions may be provided from remote data and computing location 300 to apparatus 100. It is further contemplated that a plurality such information capture apparatuses 100 may be coordinated to monitor a larger space than a space that can be covered by a single such apparatus. Thus, the apparatuses can be made aware of the presence of the other apparatuses, and may operate by transmitting all information to one of the apparatuses 100, or these apparatuses may each independently communicate with remote data and computing location, which is adapted to piece together the various information received from the plurality of devices 100.
[0028] Referring next to FIG. 2, a more detailed view of a preferred embodiment of remote information capture apparatus 100 and remote data and computing location 300. As is shown in FIG. 2, apparatus 100 comprises an information capture device 110 for capturing video and audio data as desired. A motion detector 115 or other appropriate trigger device may be provided associated with capture device 110 to allow for the initiation and completion of data capture. Information capture device 110 may comprise a visual data capture device, or may be provided with an infrared, night vision, or other appropriate information capture device. A storage location 120 is further provided for storing captured information, and a processor 130 is provided to control such capture and storage, as well as other functions associated with the operation of remote information capture apparatus 100. An analysis module 135 is provided in accordance with processor 130 to perform a portion of analysis of any captured information at the remote information capture apparatus 100. Apparatus 100 is further provided with a display 140, and a data transmission and receipt system 150 and 160 for displaying information, and for communicating with remote data and computing location 300. Remote data and computing location 300 comprises system management functions 330, and a transmission and reception system 350 and 360 for communicating with apparatus 100. Such system management functions comprise, at least in part, many of the centralized functions noted in the three pending patent applications noted above and previously incorporated herein by reference. Transmission and reception system 350 and 360 may further comprise various GPS modules so that a location of the device can be determined at any time, and may further allow for a message to be sent to one or more individual apparatuses, broadcast to all apparatuses in a particular trial, or being used for administration of a particular prescription regimen, of broadcast to all available apparatuses.
[0029] In accordance with the invention, apparatus 100 is adapted to be part of a system that improves adherence to medical protocol in both a clinical trial and other medication administration setting. Users of apparatus 100 in accordance with this system give administrators a tangible and concrete manner in which to confirm compliance or lack thereof, and the ability to intervene early in the process to ensure that patients enrolled in such a clinical trial study are properly taking their medication. Apparatus 100 of the invention is adapted to receive instructions for patients from remote data and computing location 300 and provide these instructions to patients on the use of the prescription medication. Such instructions may comprise written, audio or audio visual instructions for guiding a user to adhere with a prescribed protocol. Apparatus 100 further provides verification to a doctor or other service provider of patient adherence to the prescribed protocol, and statistical and individual analysis of adherence rates to ensure proper medication administration.
[0030] Referring next to FIG. 3, a data flow overview on accordance with the operation of apparatus 100 is shown. In accordance with the invention, information about a particular drug to be the subject of a clinical trial or other medication administration program or prescription is provided in a database 405, and existing industry medication information databases 410 are employed to access prescription, interaction, application and other available information about any number of proposed prescription and non-prescription medications and their possible interaction with the clinical trial medication. Further, patient medical records 415 are used, and as will be described below, are used in conjunction with the industry medical information and a medical professional's prescribing expertise to confirm that a patient is a good candidate for such a clinical trial. These databases may be accessed via apparatus 100, or from remote data and computing location 300. Once confirmed, a medicine regimen in accordance with the clinical trial or other prescription requirements is prescribed and entered into the system of the invention at 420. Once entered into the system, a particular prescription regimen causes a set of user instructions 425 to be generated and transmitted to apparatus 100. In a clinical trial setting, such instructions may be varied for different users to determine the best set of instructions, or may be varied based upon demographics, experience, or other factors that may require different types of instructions to be provided. It is further contemplated in accordance with the invention that multiple clinical trials or patient populations may be managed by a manager in accordance with the invention so that the invention contemplates a medication administration system that allows for a single point of management for all clinical trials or patient management groups associated with a particular manager or the like.
[0031] Such user instructions may include general instructions about the particular medication subject to the current trial or medication administration protocol, methods for ingestion, warnings about side effects, concerns about drug interactions with common substances or medications, or other medications prescribed to the patient by the system or by another medical service provider. It is contemplated in accordance with the invention that such set of user instructions may be interactive, allowing a user to view additional information about such instructions or prescriptions as desired. These instructions may comprise written, audio or video instructions provided to the user on display 140 of apparatus 100. Furthermore, it is contemplated in accordance with the invention that at various points during the instruction set, for example when a patient asks a particular type of question, or asks to receive additional information about a particular aspect of the medication or prescription regimen through entry of information into apparatus 100, that apparatus 100 may reach out and contact a representative of a medical service provider via the transmission and reception systems 150 and 160 to provide the patient with additional, personal help as necessary, if it is determined that such intervention by the medical professional would be desirable to the patient. Thus, such a patient may be assisted in properly taking medication so that various errors do not take place. Indeed, in more traditional scenarios, it is only after perhaps finishing a prescription regimen and a return to a doctor in accordance with a predetermined clinical trial schedule that it is discovered that the medication may have been taken incorrectly. In accordance with the present invention, early intervention with such issues can be exercised to deter any possible unfortunate outcomes from improper administration of medication, and to ensure that the particular patient is able to remain in the study and provide accurate data to the study.
[0032] It is contemplated in accordance with the invention that a touch or other user friendly graphical user interface be provided associated with apparatus 100 so that the user can easily manipulate any number of prescription factors, and perhaps enter additional information that may be useful to a prescribing medical provider, such as level of fatigue, level of hunger, jitter inducing medications, etc. All of these data collection points allow for a smoother administration of medication to a patient, and therefore a more likely chance of adherence to a prescribed protocol.
[0033] Referring to the lower portion of FIG. 3, the horizontal line indicates a time for patient ingestion or other administration of medication. The patient may display a medication container and/or an actual pill or other medication form to imaging capture device 110 of apparatus 100 at step 430, which in turn may perform local processing and analysis via processor 130 and associated analysis module 135. Apparatus 100 confirms that the medication is correct and is the currently prescribed medication to be taken through the use of text recognition, pill recognition, or other appropriate medication recognition scheme. This sequence of steps therefore acts as an audit trail each time a medication is taken, that can be reviewed later, to ensure that a patient is properly following a regimen.
[0034] In accordance with the invention, confirmation of patient adherence to the prescribed administration schedule for the medication as prescribed by the clinical trial or other prescription regimen is determined. While such confirmation may take a number of forms, in accordance with the invention, a preferred method for such confirmation may include capturing a video sequence of the patient actually administering the medication by apparatus 100. In a further preferred method, such a sequence for such confirmation may include employing a facial recognition sequence or other biometric confirmation that a particular patient is in fact receiving treatment, but may also provide for the ability to obscure the face or other identifying feature of a user to allow for the storage and use of such images while protecting the identity of the patient, a technique that may be beneficial when a manager is providing a general report about the clinical trial, and not trying to remedy a situation with a particular patient. Activity recognition, gesture recognition or other feature for determining whether a particular subject movement meets a predefined movement sequence may be employed to be sure that the patient is properly taking prescribed medication.
[0035] Furthermore, in accordance with the present invention, a video image of the patient actually administering or ingesting the medication may be taken in accordance with apparatus 100 and stored in memory 120 so that actual confirmation may be achieved, rather than simply relying on the patient to state that a particular medication was administered. Such a video image may be captured or stored in any appropriate format given a selected type of activity or gesture recognition that is employed in accordance with a particular embodiment of the invention. Such may include full video, biometric data points, recording of movement of an article, such as a bracelet or the like, affixed to the patient or administrator, use of mapping to provide a stick figure or other body movement tracking technique, or gesture or activity recognition to determine movement or the like. The user may be encouraged to use a particular sequence of movement to be confirmed that they are properly administering the medication according to the protocol, thus reducing the possibility of the potential appropriate movements considered to be "correct." Indeed, various instructional videos or other appropriate training may be provided to a user to insure they properly administer the medication. Finally, in accordance with the invention, if recording of a video of a patient having the medication administered thereto is not possible, the system of the invention will recognize such an issue and request audio confirmation via apparatus 100 as a next best option. If the audio confirmation is also not possible, then a less reliable method of confirmation, such as a keyboard confirmation by the patient may be accepted. If higher reliability methods of confirmation are not available for an extended period of time, an alarm is preferably forwarded to a medical professional to inquire as to reasons and to remedy any situation that might be wrong in the administration situation.
[0036] These steps of confirming identity, confirming medication and confirming administration are then reviewed to verify adherence to the prescribed protocol at 435. Such review is preferably performed automatically first by processor 130 and analysis component 135 thereof that is able to align the actual recorded images with ideal or expected images, or through the use of other activity or gesture recognition as mentioned above. In the case of facial recognition and bottle or pill recognition, such techniques are known in the art. With regard to video confirmation of adherence to prescribed medicine administration procedures, such processing may include various stick figure comparison analyses, activity recognition analysis, or other schemes as noted above able to determine whether appropriate actions have been performed by the patient.
[0037] The ability to provide automated determination of adherence to proper administration procedures at the apparatus 100 allows for a first, quick review of any such images to determine whether any immediate attention may be warranted. As will be described below, further review at remote data and computing location 300 allows for a large number of such images to be reviewed in a short period of time. Even if actual and complete lack of adherence is not able to be determined 100% in each possible situation, the ability to pre screen the administration video captures to remove from further consideration administration situations that are clearly compliant may reduce a number of compliance situations to be reviewed by a medical professional substantially. Additional human review of indications of failure of adherence may be provided, thus insuring proper review of all potentially dangerous situations while greatly reducing the number of images necessary to be reviewed by a human. Thus, multiple benefits of such an automated system are realized, including reducing time to review such images, reducing costs of such review, and improving patient privacy by limiting the number of humans viewing such data, while improving quality.
[0038] In an additional embodiment of the invention the imaged sequences used for activity recognition to determine regimen adherence may be further used to check for adverse or other reactions to taking of the medication. Thus, in addition to simply determining proper adherence to a protocol at apparatus 100, such activity or gesture recognition may determine any number of different actions that may have been taken by a patient. Thus, actions taken before medication administration, or actions taken after medication administration may give insight into reasons for particular responses, etc. Thus, before administration, in accordance with the invention, activity recognition may determine a current activity of a user. Any subsequent reminders to take a medication may in part be based upon this determined activity. By way of example, if a user is putting on a coat, or is determined to be leaving a residence or other facility or the like, a reminder to take a medication before leaving may be provided, even if earlier than normal, or if medication is portable, the user may be reminded to take the medication with them, and then subsequently reminded to administer the medication via notification on a mobile device. By way of further example, if the user is cooking, a reminder may be given to take the medication a predetermined time before eating. Other scenarios may be possible, thus allowing greater response from the system to ensure proper medication administration by a patient. Additionally, various patient consent issues may be prompted and recorded in accordance with the invention. Patients may ask further additional questions regarding such consent, thus insuring that patients have all of the information they need to make informed consent decisions, and medication providers have proper evidence of such consent.
[0039] Similarly, actions after taking medication may give insight into patient responses. Notice of fainting, falling down, lack of motion, facial gestures, gastrointestinal distress or the like may all be logged as adverse reactions to a particular medication regimen, and may allow for adjustment of dosage or prescription instructions in the future for the patient. If adverse reactions are severe, an immediate medication review and contact from a medical professional may be provided to cure the issue. Additionally, the system in accordance with the present invention may be directly tied and be interoperable with a pharmacy or medical provider's systems as administered by the clinical trial manager, thus allowing such recommendations for dosage changes, regimen changes and the like to be forwarded to these professionals automatically. Through such links, reordering medication, dosage changes, medication changes and the like may be automatically provided. Furthermore, ease of providing additional prescriptions can be enhanced as patient, medication and regimen information will already be available to the pharmacist or medical service provider.
[0040] After such automatic, or combination of automatic and manual, adherence verification is performed allowing a health care provider or other medical professional to review and verify results of the automatic comparison or direct review of captured activity sequences, and indication of variation from a desired identity, medication or application procedure may request administrator review of the situation, and intervention as may be determined necessary at 440. Such review may be required immediately as an emergency situation may exist, or the patient may gesture or otherwise indicate that help is necessary, or such review may be less urgent, perhaps requiring an electronic communication with suggestions or the like from such an administrator or the like. Additionally, such adherence review may be stored over time for a particular patient, thus allowing for various medication trends to be determined, such as if a patient misses medication at a same time each week, or an indication that one particular health care worker aiding the patient may occasionally give an incorrect medication dosage amount. Thus, in addition to allowing for immediate notice of problems in medication administration, an audit trail for tracking the actions of various health care providers is generated. Such an audit trail allows clinical trial administrators or other medical professional to determine immediately, or upon review of a complete medication regimen, whether a particular patient or group of patients has followed the protocol to the level that allows their results to be used as part of the study. Additionally, levels of adherence may give insight as to the ease of use of a particular regimen, and whether instructions provided to the patient are sufficient to allow for adherence to the prescribed medication regimen.
[0041] Referring next to FIG. 4, a user implementation of the method in accordance with the invention will be described. When a time for receiving or administering a medication in accordance with a clinical trial regimen is reached, a patient, and any other necessary user may be provided a notification 510 from apparatus 100. Thus, in a home situation, only the patient may receive notification. If there is a home health care provider, such provider may also receive separate independent verification. In the case of hospital or other in-patient care facility, various medical service providers may similarly receive such notification. After notification, or in the absence of such notification, system initiation preferably takes place at 515. In accordance with such system initiation, one or more users are preferably recognized by the system. Therefore, at step 520, a user recognition sequence may be employed. In a preferred embodiment, such a user has a still or video image captured of their face by apparatus 100, and facial recognition techniques are employed to confirm the identity of the user in analysis module 135. Alternative recognition techniques, such as retinal, fingerprint, voice or other biometric measurements may be employed, in addition to a more common password query. Any other appropriate identification technique may be employed, and any unique individual identifiers may be obscured, as noted above, when the images are to be used as a more general report regarding adherence, rather than an individual patient response.
[0042] At step 525 it is determined whether all necessary users have been recognized and authenticated. In a situation where a nurse, doctor or other caregiver is to administer medication, it may be preferable to have the patient and caregiver to be recognized by the system to further confirm that the appropriate procedure is followed, and to allow the system to keep track of people using the medication so it can track if any one person, for example, is improperly using the medication, as will be evident from the generated audit trail. After step 525, if all users are not recognized, control passes back to step 520 and any additional users are recognized by the system.
[0043] Once all users are recognized, control passes to step 527 where the medication to be administered in accordance with the prescribed prescription regimen of the clinical trial is confirmed. Thus, a user is prompted by apparatus 100 to allow a still or video image, text recognition image, or other method of identifying a medication to be captured of the medication bottle or other container, a pill of the medication, or other form of medication, and is also able to determine appropriate quantities, dosage, and any potentially required or dangerous medication combinations. As noted above, if video confirmation is for some reason not available, the user may be prompted by the system to provide audio or other indication of medication and other desired information. This image, video sequence or other received confirmation information is then compared to an image associated with a prescribed prescription. If the medication is determined to be incorrect after analysis by analysis module 135, a warning may be provided from apparatus 100 to the user that the medication is incorrect. The user may then be prompted to choose another medication for imaging.
[0044] Alternatively, the invention contemplates a user displaying a number of medications to apparatus 100 and allowing the apparatus to suggest which medication is correct. Thus, the user may be able to scan a medicine cabinet with such a video imaging apparatus and have the system indicate which the correct medication is. This may prove valuable when sequence of ingesting medication is important, or when two people have similar medications and may have difficulty in distinguishing between medications for each. Once a correct medication has been identified, control passes to step 530.
[0045] In step 530 user prompts and other instructions are provided to the patient from apparatus 100, and present caregivers, as to how to administer the medication according to the prescription guidelines outlined above as determined in accordance with the particular clinical trial under consideration. These instructions allow for a user to receive further information or instructions as necessary through asking the system for additional help. Especially in situations where an elaborate scheme may be required, it is contemplated that video samples and instructions may be provided to the user. Further, in accordance with the invention, for complicated administration procedures, it may be possible to set up a two way video conference employing traditional video conferencing, VOIP conferencing, traditional telephone conferencing, or any other appropriate communication system with an expert in such administration so that a caregiver or patient may receive live coaching regarding such administration, all via apparatus 100, perhaps with additional features and elements provided to allow for such additional functionality. Such instructions and prompts may be determined by the medication manager to determine the success or failure of particular sets of instructions. Thus, not only may medications tested in a clinical trial, but also sets of instructions are tested to determine which are best for all, or for giver demographic groups or the like for eventual user when the medication is released to the public, thereby allowing for a better adherence rate by the public. As the number of clinical trials and other patient populations grows, and the locations of such trials groups become more international, such administration through a system such as that set forth in accordance with the invention may become far more important to various medication administration managers.
[0046] When following such instruction prompts, the actual act of administration is preferably captured as a video sequence at step 535 by apparatus 100 via capture device 110 and stored to storage 120. Administration preferably includes one or more identifiable gestures as suggested in accordance with the instructions above. A patient or administrator may be provided with one or more images or sequences for method of application or administration, and thus the following of these sequences is used to determine compliance with a particular prescribed regimen. Further, long gaps or pauses may be determined to give further insight into areas of administration that may be giving problems to administrators of trial participants. This captured video sequence may be utilized in accordance with the invention in a number of ways. First, the actions of administration of the medication is reviewed in real time and compared to an ideal or desired video sequence by processor 130 and analysis module 135. If a determination is made that the medication is being administered in an incorrect manner, and in a way that may be detrimental to the patient, immediate warnings may be provided at step 540 via apparatus 100 advising the caregiver or patient to stop administration at once. Furthermore, in extreme cases, a doctor or other caregiver may be notified, or in the most dangerous cases, an ambulance or other emergency personnel may be dispatched to provide immediate care.
[0047] Notification may also be provided to the clinical trial manager or other medication administrator so that this person is warned that one or more patients are having problems with adherence with the protocol. If such problems turn out to be isolated, alternative instructions, or personal help may remedy the situation, thus allowing the person to provide meaningful data to the trial. If such lack of adherence is far more widespread, a clinical trial manager or other medication administrator may change instructions for all participants, or may even ask all participants to come back in for further live instructions. In either situation, the cost of administration is greatly reduced as participants are able to remain in a study, and major failures of studies for lack of protocol adherence may be avoided. Reports based upon such widespread lack of adherence may provide a manager with a report, using images or the like with identifying features removed so that the report may show precisely how a medication is being administered while maintaining patient privacy and confidentiality. If video recording is not available, other confirmation methods as noted above may be employed and be subject to automatic confirmation as with the video recorded sequences.
[0048] If such immediate care or warning is not required, control then passes to step 545 where the video images are more formally captured, transmitted to remote data and computing location 300 and analyzed for various other non-critical issues. The images may be captured and stored locally, being provided to a central server in a batch processing, or images may be captured and sent to the remote server location 300 for immediate analysis and storage. Such analysis may consider suggestions to a caregiver to improve dosage accuracy, reduce pain in administration, or the like. Furthermore, as such video sequences may be available from multiple patients and/or caregivers taking part in a current or multiple clinical trials, the effectiveness of various sets of instructions and the like can be tested and reviewed, and changes thereto made if consistent problems are encountered. This type of study is nearly impossible without the present invention, because in any type of clinical setting, individuals are far more likely to be careful in administration of medication, and therefore not cause errors. When they return home or back to their regular lives, this is when adherence and administration issues arise. In accordance with the invention, responses to instructions can be analyzed, and lack of adherence based upon confusing or difficult to follow instructions can be remedied, providing better or more usable instructions, and therefore improving regimen adherence. Without the present invention, such a clinical trial manager may be unaware of such issues. With the invention, these issues can be addressed as they arise, thus ensuring the integrity of the clinical trial.
[0049] In any event, after such analysis, any warnings or suggestions for instruction issues may generate a warning at step 550, suggesting areas of instruction that may be problematic. These video sequences are also stored for longer term analysis if desired at step 555, and processing ends. Furthermore, in order to encourage patients in the clinical trial, notices of lack of adherence may be used to change remuneration received by a patient in the clinical trial. Thus, adherence to the protocol results in higher payments to the patient, a great incentive for the patient to adhere to the protocol.
[0050] Trends of a patient taking part in the clinical trial or other medication administration program can be monitored by apparatus 100 in accordance with the provision of additional diagnostic attachments, such as blood pressure or other measurable quantities of the patient, and correlation between such measured quantities and medication administration may be observed, potentially allowing for a more customized solution of medication to be applied to the patient, possible modifying dosage or frequency of administration based upon individual reactions to a particular prescription regimen. Additionally, features of the invention noted above allowing for user interaction and recordation of activities of a user, adverse effects and the like may be incorporated into the system to provide further information for determining alternative instruction sets, modification of medications and the like.
[0051] Thus, provision of such an apparatus 100 increases effectiveness and allows for better control over medication administration. Difficulties in following protocols may be determined in near real time. Changes in a medication protocol may be easily implemented and conveyed to patients and their prescribing doctors. New training modules, including video, written, or other instructions may be provided improve adherence. Inventory management is eased and all patients are sure to have the appropriate amounts of medication and other supplies. The system and apparatus 100 can be used by a single medical provider, doctor group or network, insurance company, governmental agency, nursing home, hospice, home care provider or the like, or other group in order to track any number of patients and associated home care workers, doctors, or other medication administrators.
[0052] All communications in accordance with the invention are preferably encrypted or otherwise protected during transmission and storage at both local and remote mass storage location to meet any security issues and any regulations required for the storage and maintenance of medical and patient health care information.
[0053] Alternative embodiments of the invention may provide one or more of the following additional features. Rather than simply providing a video capture in a traditional sense, apparatus 100 may be provided with night vision, infrared vision, or other desired capture scheme. Apparatus 100 is also contemplated to be provided with a number of apparatus management features, including an ability to choose between color and black and white video storage and transmission, auto focus on a patient or the like, and including tracking of such an individual as they move about a room, the ability to strip any identifying information from transmitted video so that anonymity can be maintained, if desired. Apparatus 100 may include mechanisms to indicate a need for recharging, and include sleep modes for extending battery life. It is further contemplated that apparatus 100 may act as a monitoring device for a patient, and in a standby mode the apparatus may "listen" or "look" for sounds from the patient, including suggestions of a fall, scream or the like. Automated responses may be provided in order to access patient status via integrated speakers or the like. The transmission system of apparatus 100 may then notify appropriate personnel. Thus, the portability and multiple use areas provide an additional benefit to the user of this apparatus.
[0054] Therefore, in accordance with the invention, a method and apparatus are provided that allow for the automated confirmation of adherence to administration protocol for medication, and provide for a most sophisticated method for confirming and studying methods of administration of such prescription medication.
[0055] It will thus be seen that the objects set forth above, among those made apparent from the preceding description, are efficiently attained and, because certain changes may be made in carrying out the above method and in the construction(s) set forth without departing from the spirit and scope of the invention, it is intended that all matter contained in the above description and shown in the accompanying drawings shall be interpreted as illustrative and not in a limiting sense.
[0056] It is also to be understood that this description is intended to cover all of the generic and specific features of the invention herein described and all statements of the scope of the invention which, as a matter of language, might be said to fall there between.
Patent applications by Adam Hanina, New York, NY US
Patent applications by Gordon Kessler, Mt. Kisco, NY US
Patent applications by AI CURE TECHNOLOGIES LLC
Patent applications in class Health care management (e.g., record management, ICDA billing)
Patent applications in all subclasses Health care management (e.g., record management, ICDA billing)
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Get the MessageSign up for my secret message! When you get it, you'll be able to submit your own guest audio post. And I can send you other cool stuff.
Top Posts
Companies set up systems in order to produce their products, then they put their heads down and produce.
"We don't have time for that new fangled mumbo jumbo, we're busy doing real work here."
I wonder when the first company decided that telephones were a good idea to give their workers?
And give a computer to every employee? That's crazy talk!
I do remember when everyone in our company was given full access to the internet. That was quite the controversy. "They'll just be surfin' the web all day." Maybe, but it seems like each new advance in tools or technology requires a lot of trust. Mostly because the most powerful tools can be used for good or bad, productivity or wastefulness, innovation or drivel.
Well, here we are in another phase of new tools – Web 2.0. It seems like companies should be able to learn from the past. And I think they are, but there is still resistance, and progress is slow. Again, trust is a factor, plus a lack of understanding of the impact or potential that the new tools can provide.
Here is a great article from a reputable source (McKinsey) on how companies can make the new Web 2.0 tools work for them.
The info is out there. Companies really have no excuse for not understanding and benefitting from new things.
It's a phrase that makes people feel good, one that generates confidence, accomplishment. It's something we all want to do. However we define 'things', we want them finished, complete, closed, accomplished.
David Allen was a management consultant that began to see the DNA of how things got done and then developed a method, a step by step process, even an entire philosophy around personal productivity and the business of 'getting things done'. His books continue to grow in popularity and he is now (and has been for a while) one of the most recognized names in the personal productivity arena. He basically owns the phrase due to his first book, "Getting Things Done", and his methodology is now referred as GTD.
His second book focused more on the philosophy and principles behind the method and is a collection of short essays called "Ready for Anything". I actually read that one first and thoroughly enjoyed it. I've also come back to that one quite a few times for re-reading and study, to help me get back on track.
His latest book, just recently released, "Making it All Work" is supposed to provide new perspectives and help you reach new levels of productivity. I haven't read it yet, but probably will at some point.
His core premise is that one's ability to be productive is directly proportional to one's ability to relax. He uses the "mind like water" analogy where water responds with total appropriateness to a pebble being thrown in it. It doesn't overreact or underreact, it simply interacts with whatever comes to it and returns to its natural state.
He defines 4 main areas of productive behavior:
People don't need more discipline as such – they need a more discipined approach. It's not about working harder or getting your priorites straight, it's about defining your work better at multiple levels of detail and staying focused on all of them simultaneously.
I highly recommend investgating David Allen's work. I have not mastered his method perfectly yet, but his concepts help me to understand all the things I have to do in a different way, and therefore helps reduce my stress.


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Elizabeth R.
Teaching Locations:
Teaching Locations:
Levels taught:Beginner, Intermediate
About Elizabeth R.
Elizabeth is a professional piano teacher and has taught piano/keyboard lessons for 20 years to children ages 5 and up and to adults of all ages. She is a graduate of Columbia College and has a Bachelor of Arts in Music and Arts Administration. She started playing piano at age 7 and had many years of formal classic and pop piano lessons. She's taught piano at a music studio for over 13 years and had a waiting list. She has been an accompanist for several groups including various college and high school choral groups and vocalists.
Liz loves teaching all ages whether children or adults. She loves teaching beginners/newbies and watching them progress and find creative expression through music. She wants to inspire and bring out each student's best in a fun, positive, supportive, and patient atmosphere. She hopes to help bring students the love and joy of playing the piano that she has always had .
Lessons are online from the comfort of your own home.
Please email teacher for other lesson time availability if needed.
Teaching Style
I tailor lessons to meet each individual's needs and learning styles/abilities. I use method books along with popular music methods and let the student pick music they like to go along with it. Lessons include harmonization, ear training, transposing, improvisation, and multi-sensory learning. I believe in positive encouragement, patience and a supportive environment to help build student's confidence as they learn.
Also, I specialize in helping students that are especially nervous about taking lessons. The studio I taught at often recommended me for students that were afraid, more sensitive or shy with lessons.
I believe teachers should always be learning as well. I study, research, attend seminars and look for new ways and methods to improve lessons and grow as a teacher.
Would love to help bring the joy of making your own music in the moment to you!
ReviewsWrite a Review
Elizabeth is a great teacher with many years of experience. I am learning faster than I imagined I could! Her teaching methods are far superior to other ones I have tried in the past. The piano is a wonderful instrument of which I plan to master very soon with Elizabeth's great help. I recommend anyone interested in learning to play the piano to take lessons from Elizabeth. Many Thanks!
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BA Music and Arts AdministrationSep 1982 - Jun 1986
Columbia College
Fluent / Native Proficiency
Let Our Student Counselors Help YouWe can match you with the perfect teacher and take care of all your scheduling needs.
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NNEF Non-Executive Members
The NNEF planning group also has a number of non-executive members who may be called on from time to time to do small pieces of work for the forum.
Jane Askey
Tim-Jake Gluckman
James Pierce
Judith Yates
Paddy Noonan
Mark Tudor
Jasmin Mulrooney
Steve Bliss
Emma Stowe
Lisa Byrne
Dave Estabrook
Jamie Bridge
Aurielle Ballin
Una King
Stuart Haste
If you are interested in becoming a part of the planning group we recruit new members at our AGM meetings which are normally arranged to coincide with one of our events. Come along and get to know us.


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I am a destruction ecologist not restoration ecologist.
In most of my primary ecological fieldwork, we take things apart. We clear plots, remove individuals and sometimes immediate neighborhoods, or clip plants. This is not entirely without its merits. In some happy instances, the interactions we detected in the absence of others can inform restoration albeit indirectly. For instance, in an alpine-neighbourhood-removal experiment, plants near targets facilitate these individuals at higher elevations (Callaway et al 2002).
In some of my dissertation research, I explored whether the loss of even tiny little desert annuals (but the relatively 'larger' ones) could influence patch dynamics. We did selective removals of the subdominant annuals and demonstrated some positive not always negative effects of larger congeneric species as typically assumed for these systems (Lortie & Turkington 2008).
I also like the much larger-scale ideas of biodiversity knockout experiments (http://www.zoology.ubc.ca/person/sinclair) as a means to explore the implications of loss of entire functional groups (or see metabolics/genomics approaches or the work of Diaz & others on different types of ecological removals). Collectively, I suspect there is a nice opportunity for restoration to address some of the challenges it faces using experimental designs predicated upon removal. Also, I suspect that anthropogenic effects can also remove players from ecosystems relatively regularly and that experiments emulating some of these perturbations can be informative. This got me thinking that like most ecology, restoration ecology could be very plug and play.
We add, we remove, and/or we observe. However, there is a fourth approach available to restoration ecology in the form of needs-driven research and perhaps in particular syntheses. For instance, the work of Science for Nature and People exploring the importance of evidence in shaping human dynamics and management.
Inspired by these initiative, I want to do a synthesis. I do not want to do it alone. Help me! I love the idea of 'grand challenges' for a discipline. If Obama can do it, we can do it too! See the #wethegeeks series mostly for engineering. There is also a Grand Challenges in Global Health Program that is a really amazing.
I am very keen to become a restoration ecologist in some form maybe when I grow up. A synthesis of the challenges faced by the discipline, formally, would be a fantastic exercise in determining how an individual new to the field could contribute. I imagine that some of the challenges that restoration ecology faces are not unique to it relative to other ecological disciplines such as access to open data, divergent semantics and non-standard vocabularies, funding, relevancy, and partnership expectation challenges. However, I would love to know what challenges are unique to restoration ecology and how challenges faced in other disciplines also speak to this field. There have been some nice discussions of challenges in general for restoration (practice, paradigms, policy, & principles for specific systems), but to the best of my knowledge, there has been no formal and global synthesis as a primer to facilitate getting started and in avoiding/addressing some of the common pitfalls. There has been many formal syntheses in the form of meta-analyses (see Gomez-Aparacio for instance on plant interactions for restoration or socioeconomic benefits of restoration by Aronson et al) but none at the global-thematic scale. I envisage the first steps to this process as a brainstorming of questions that need to be addressed for the discipline and a long list of challenges. Then, a matching exercise to explore whether there is correspondence between the questions being actively pursued and the challenges that restoration ecologists face.
Final step, solutions – perhaps even a general blueprint.
The synthesis could take many forms but a great step would be the big picture summarized.
General questions
1. How well does conservation biology and restoration ecology support and enable one another?
2. Does fundamental ecological theory significantly contribute to restoration ecology or does most restoration begin with a 'problem' that needs a solution?
3. Is most restoration ecology manipulative? How are mensurative experiments and observation leveraged in restoration ecology?
4. How inter-related are management and restoration in their alignment of needs and research agendas?
5. Are there syntheses of the local-versus-regional drivers that influence the outcome restoration efforts?
6. How commonly are the human factors included in restoration efforts or in experiments?
7. Does social science regularly contribute and support restoration efforts?
8. Does socioeconomic research support restoration? When it does, how it is used?
9. Is an effective restoration plan similar to a conservation blueprint?
10. What are main primary research topics that restoration ecologists examine? Are there taxa and/or ecosystem specific biases and how general are the lessons?
11. What is the most common scale of restoration?
12. Are there themes that transcend restoration and speak to a wider audience?
13. Is restoration ecology increasing collaborative similar to other disciplines?
14. Are restoration ecology experiments often interdisciplinary?
15. What are the main challenges that most restoration ecologists would list in either doing research or in implementing a restoration effort?
I hope this set of questions is a good start in getting the ball rolling. I suspect a survey of experts in the field, a formal systematic review, and maybe a workshop and we would be up and running towards a nice list of grand challenges!


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Blum - Blumotion Tandembox + Standard Drawer Box for 1000mm Cabinet
Blumotion soft close drawer box for 1000mm cabinets
Will fit in a space of
- Depth (Back to Front): 450mm.
- Width (Left to Right): 964mm.
- Height (Top To Bottom): 105mm.
TANDEMBOX antaro - More than meets the eye
TANDEMBOX antaro inspires users with its versatility. The round gallery and different heights of drawer sides and backs hold out a multitude of applications. You can have an open or a closed contained, a single or a double gallery - the choice is yours with TANDEMBOX plus.
- Colour range: grey (RAL9006)
- Inner pull-out front fixing is made of nylon; all nylon components are dust grey
- Installation heights: N, M, K, B, C, D and G
- Nominal lengths: 270 - 650 mm
Advantages at a glance:
- Versatility of programme produces a multitude of applications
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Recently launched Pradhan Mantri Schemes
Over the last couple of months most of us are likely to have heard of the recently launched low cost Pradhan Mantri Schemes, thanks to the huge publicity through advertisements, hoardings and our personal bankers sending us emails on how to avail of these. Though most of these are low premium, low benefit schemes primarily targeted at the lower income group, it is open for all. If one does not need these for himself or herself, he or she can help their domestic helps/workers and businessmen can encourage their employees to subscribe to these. More details as follows-
Pradhan Mantri Jeevan Jyoti Bima Yojana Continue reading →
Sukanya Samriddhi Yojana for the girl child
The Sukanya Samriddhi Scheme was launched in January 2015 by the Indian Prime Minister under the " Beti Bachao, Beti Padhao" initiative of the Government of India. The objective of this scheme is to financially secure the future of the girl child – who is still considered a liability on parents in many sections of our society.
Product Review – Long term tax free bonds
Currently, the market is flooded with a host of tax free bonds of 10 year and 15 year duration. There are as many as nine such IPOs which are on. All from government companies with a high safety rating and low credit risk –
Rajiv Gandhi Equity Savings Scheme (RGESS)
Budget 2012 had proposed introduction of a new tax saving scheme called the Rajiv Gandhi Equity Savings Scheme (RGESS) for investors with an income below Rs 10 lakh per annum, to be effective from the financial year 2012-2013 relevant to the assessment year 2013-2014. This scheme has been approved and the features of the scheme are as follows:
Shriram City Union Finance secured NCD public issue
Shriram City Union Finance, an NBFC, has come out with a secured NCD issue which is open from 12th Sept – 26th Sept 2012.
What are secured NCDs and how safe are they?
NCDs stand for Non-convertible debentures are debt instruments issued by corporates and NBFCs (Non Banking Finance Companies) and they are secured by a charge against the companies' assets. This means that in the event of liquidation of the company, the claims of NCD holders will be given preference over the unsecured asset holders like the share holders.
Product Review: Reliance My Gold Plan (RMGP)
Reliance Gold in association with the world gold council has come up with a new product offering- a gold plan to accumulate physical gold through monthly periodic payments.
Target Segment-
People who want to accumulate gold for their personal use.
Product Review : Birla Sunlife Recurring Savings Plan
Birla Sun life Mutual Fund has launched a recurring savings/systematic investment plan which also offers an optional free life insurance cover to the investors, the amount of which is determined by their regular installment amount.
About the scheme:


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Choose a country in the list to show prices and articles for that country
Size guide ISBJÖRN of SwedenThe measurements should be measured on the body to find the right size, not on the garment.
Windproof pants, protective pants, rain pants. Yes, the things we love have many names. Here at Isbjörn we call them hard shell pants. This is an outer layer that keeps out the wind and rain, and the outer fabric is lined with a membrane that allows excess heat to escape. Consequently, your child always remains suitably warm and dry. Whatever the weather and whatever the activity. Taped seams throughout prevent water seeping through in wet or rainy weather. Our Kuling hard shell pants are made from an exceptionally strong nylon fabric called Oxford Nylon Taslan, which has far greater durability than normal polyester. As a result they can easily withstand everyday wear at preschool and school, with no loss of the functionality you expect as an Isbjörn customer. Our Kuling hard shell pants have a high waist with a zipper at the side, as well as permanent adjustable braces and silicone elastic at the ankles. With a suitable mid layer underneath, these pants can be worn all year round. In other words, with Kuling hard shell pants there's no longer any need for a waterproof suit.


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I don't have much to say about this unique pizza from Vegan Planet except…YOU MUST MAKE IT.
Seriously. This is a pizza like no other. The book bills it as a spicy black bean pizza, but guys…this is a burrito pizza. Part of the topping is a soaked and pureed chipotle chili. The rest of it, as the recipe goes, is salsa, black beans, and minced fresh cilantro.
I took a few liberties with the recipe to make the pizza more substantial. First, I had spinach left over from making breakfast burritos, so I chopped some of that up and mixed it in with the other topping ingredients. I love spinach in burritos so I figured it would make a good addition–and it did! Second, I sprinkled a cup of pepperjack Daiya shreds on top for extra spice. For the salsa, I used Salpica brand Texas Picante, but I'd love to try it with fresh, homemade stuff when tomatoes come in season. I also used a mix of black and red beans since that's what I had on hand.
So, make this pizza the next time you want something a little different. Since it's a nicely spicy pizza, I wouldn't recommend using a hot salsa on it. Unless that's how you roll, of course.


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First mooted in 2013, NEET became the sole exam for entry into all medical colleges from 2016 after prolonged court battles with deemed universities, minority institutions and states contesting the common test on a myriad grounds.
The Centre is looking at a proposal to make the National Eligibility Cum Entrance Test (NEET) mandatory for students planning to study medicine abroad, a senior health ministry official has said. Clearing NEET is a must to study medicine in any government or private medical college in India. Under the new proposal on which the Union health ministry has started stakeholder consultations, a student who has not cleared NEET will not get the Essentiality Certificate (EC) from the Medical Council of India that is required for admission in any medical college outside India.
First mooted in 2013, NEET became the sole exam for entry into all medical colleges from 2016 after prolonged court battles with deemed universities, minority institutions and states contesting the common test on a myriad grounds.
According to government sources, the ministry may, at a later stage, look at the option of issuing ECs only to students going to institutions that rank high on their respective national lists. Both moves, the government hopes, will streamline foreign medical education and raise the dismal pass percentage in the Foreign Medical Graduates Examination (FMGE) that students have to clear before they get the licence to practise medicine in India.
"The pass percentage in the FMGE examination every year is in the range of 10-15 per cent. This is a function of two things — the quality of intake and the quality of training that the colleges impart. There is a need for some sort of control over this because there is no point in Indian students going for a five-and-a-half-year course abroad that costs a lot of money and then not being able to practise medicine once they come back. So we are looking at making NEET mandatory even for students intending to study medicine abroad. We have already started consultations," said the senior official in the health ministry.
About 6 lakh students qualify NEET every year of which only 67,000 can be accommodated in Indian medical colleges and another 27,000 in the dental colleges.
"In countries where the accreditation system is reliable, ECs may be issued only for the top institutes and not for the others," the official added.
In the case of NEET exemption for a year in Tamil Nadu, the health ministry has sought the opinion of the attorney-general on an ordinance the state wants to bring. The law ministry has already cleared the ordinance.


text: This thesis aims to explore the nature of dreams and the translation of dreamscapes into visual art. Growing up with sleep apnea, I hardly dreamt, and never remembered my dreams. After being diagnosed in 2010 and beginning treatment, I began to dream vividly. To date, my dreams are incredibly evocative, and I keep a dream journal. The journal consists mostly of sketches, quotes, and certain words that come to mind upon waking. For each dream, I have created one or two paintings. This process yielded over one hundred works on paper, created with a mixture of oil paint, acrylic ink, and mixed media. The project culminated in a book featuring selected works, accompanied by thoughts on dreams from Carl Jung and words that epitomize the collection as a whole.


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A $1 billion deal announced last year for the sale of Dick Clark Productions ("DCP") to Chinese billionaire Wang Jianlin's Dilian Wanda Group has been called off.
MusicRow received DCP owner Eldridge Industries' official statement on March 10.
"Eldridge Industries announced today that one of its affiliates has terminated its agreement to sell Dick Clark Productions to the Dalian Wanda Group. Wanda had agreed to acquire Dick Clark Productions in November 2016. Eldridge's affiliate terminated the agreement this week after Wanda failed to honor its contractual obligations. Eldridge's affiliate also has filed with the Delaware Chancery Court to compel release of the balance of escrowed funds to which it is contractually entitled given Wanda's failure to consummate the sale."
Billboard reports the suit seeks to recover half of a $50 million "reverse termination fee" connected to the deal.
The Academy of Country Music Awards is a 50/50 partnership with Dick Clark Productions and the academy. Additional interests of DCP include 100 percent of TV rights of the Billboard Music Awards, American Music Awards, and the New Year's countdown celebration in New York.
In 2015, Dick Clark Productions was sold by Guggenheim Partners—from a reported $370 million sale in 2012—to Todd Boehly, a executive at Guggenheim. Boehly formed Eldridge Industries whose assets, among others, also include The Hollywood Reporter and Billboard.
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About the AuthorEric T. Parker oversees operations and contributes editorial for MusicRow's print magazine, MusicRow.com, the RowFax tip sheet and the MusicRow CountryBreakout chart. He also facilitates annual events for the enterprise, including MusicRow Awards, CountryBreakout Awards and the Rising Women on the Row. [email protected] | @EricTParker
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Beneficial Soil Solutions is dedicated to promoting environmentally sound, cost effective strategies and solutions to remediate environmental liabilities. Our customers benefit from the vast experiences of our founders, who have industry specific experience in facility ownership, technology development and material end use development.
We have partnered with treatment facilities and landfills in the Northeast, providing them with a consistent supply of soils to meet their many needs.
In addition, we continually evaluate emerging technologies dedicated to the beneficial reuse of waste materials.
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Our customers are our first priority. We view each customer as a unique opportunity to provide outstanding service.
We pride ourselves on offering our customers an array of disposal options, with each solution based on our personalized assessment of their project and specific needs.
We take pride in our hands on service, guiding our customers through every aspect of their unique soil remediation project.
Areas We Regularly Serve
We have worked with customers throughout the eastern seaboard, including organizations located in Maryland, Delaware, Pennsylvania, New Jersey, New York, and Connecticut.


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ExactTarget co-founder turned food entrepreneur Chris Baggott approached Studio Science to help take his latest idea from concept to reality.
Recognizing the explosive growth of food trucks across the country and increase in food delivery technology, Baggott decided to combine the two phenomenons into a brand new concept in online ordering—ClusterTruck. With Studio Science's startup experience, he chose to partner with Studio Science to bring ClusterTruck to life (and food to your door).
Despite the number of food delivery options available, consumer expectations for food delivery apps remain relatively low based on selection, food quality, timing, and the overall experience. The ClusterTruck App would need to overcome the existing perception issues surrounding food delivery apps, while still fulfilling the consumer's desire for the food truck experience. People visit food trucks because they are seeking novelty—from the spectacle of the truck, to the over-the-topness of the food.
In order to revolutionize the food service industry, ClusterTruck needed insights into the needs and underlying motivations of their target audience. It was crucial to dig deeper into how ClusterTruck can enable technology to better ease customer pain points and raise the status quo.
Studio Science began with a discovery phase aimed at understanding the needs, desires, and key motivations of ClusterTruck's target market. In addition, the research team attended a food truck festival in Indy to gain first hand-experience, truly understand consumers and position ClusterTruck for success.
Every aspect of the ClusterTruck brand needed to align with the notion of revolutionizing how people consume food—from visual identity to messaging. The content strategy was brought to life by informal real-time engagement with individual customers and bold language.
Brand is simply part of the solution. Execution is key; considering the entire user experience—from login to follow up after delivery. Studio Science designed a streamlined ordering and delivery service across web and mobile devices.
ClusterTruck launched in the Spring of 2016 with eminent success in Indy, amassing thousands of customers, and raising more than $3 Million in capital. The model has been so successful that ClusterTruck is now expanding to serve Cleveland, Columbus, Denver, Indianapolis, Kansas City, and Minneapolis.
Studio Science continues to partner with ClusterTruck, keep an eye out for new work and company updates.