text: How confident is Paul Mueller after making the top 50 cut for the fourth straight time on the Bassmaster Elite Series Tour? How tough is the Chesapeake Bay and what has he learned from the first two tidal stops on the tour that has helped him on the bay – the Sabine River and the California Delta? On day 2 his faith in God was tested; what event caused it and how did Paul Mueller respond? Sit back and enjoy a double dip of the Pro Bass Insider Podcast as we continue to follow Paul Mueller's Rookie Season "A Journey Through the Elites".

subset: commoncrawl


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Trump Gets a Deal
Under the threat of tariffs, the Mexican government reached an agreement with the United States late Friday to increase their cooperation to secure our border. Kudos to Vice President Mike Pence and Secretary of State Mike Pompeo, who ably represented President Trump in the negotiations.
The Mexican government has reportedly agreed to send 6,000 National Guardsmen to their southern border, which is only 600 miles long. That deployment will go a long way toward halting the human wave that is coming up from Central America, through Mexico and into the United States.
Mexico halted one caravan last week and has begun arresting migrants riding "the Beast," a freight train that runs through Mexico.
Mexico agreed to hold more Central American asylum seekers in Mexico while we process their cases. And Mexico also agreed to crack down on human smuggling, as well as those financing the caravans.
None of this is carved in stone. Previous Mexican administrations have made promises in the past and never enforced them. Some points of agreement will require approval by the Mexican Congress and could be derailed there. But President Trump warned yesterday that the tariff threat remains if Mexico fails to deliver this time.
We'll see what happens. But just think about how much stronger the president's position would be if "the loyal opposition" wasn't all in for open borders.
When the deal was announced, Nancy Pelosi was furious and she condemned the president's tactics. Chuck Schumer mocked the agreement.
Pelosi and Schumer sent signals to the Mexican political establishment that there are powerful forces in the United States working against the president to keep our borders wide open.
And I won't even bother with the Republican senators who were complaining about the president's use of tariffs as leverage to secure this agreement, while nothing is moving in the Republican-controlled Senate or the Democrat-controlled House to deal with the assault on our border, except for one curious development last week. (See next item.)
Immigration & Identity Politics
We may have to alter the inscription on the Statue of Liberty. As you know, the famous poem says, "Give me your tired, your poor, your huddled masses yearning to breathe free…" If House Democrats get their way, we may need to add to that list, "your pregnant, your transgendered and mentally disabled."
What I am talking about?
House progressives slipped a requirement into an appropriation bill last week that the Department of Homeland Security prioritize certain categories of illegal immigrants who cannot be deported. Among them are: "(A) pregnant women; (B) individuals identifying as lesbian, gay, bisexual, or transgender; and © mentally or physically disabled individuals."
The president wants give the highest priority in our immigration system to those with skills who can fill job shortages in the United States. The left's idea of reform is to impose its radical identity politics into our immigration policies.
What does someone's "gender identity" and private bedroom behaviors have to do with immigration?
Meanwhile, the left-wing California legislature just passed a new program to provide healthcare to illegal immigrants, costing California taxpayers another $100 million a year.
Impeachment Hearings Begin
Do you remember John Dean? No, not the late actor James Dean or the sausage guy Jimmy Dean. John Dean was in the news 46 years ago for his role in the Watergate scandal. Dean was convicted of obstruction of justice, disbarred and spent four months in prison.
But he testified yesterday before the House Judiciary Committee on the Mueller report and the Russia collusion hoax. What does John Dean have to do with Mueller and Russia?
Has John Dean done business with Donald Trump? Not to my knowledge.
Has Dean spent a lot of time in Russia? No.
He has zero relevance to this fake controversy other than he engaged in a cover-up decades ago and he thinks this is another cover-up.
House Judiciary Chairman Jerry Nadler had Dean testify yesterday for theatrics, just to give the Russia hoax a whiff of the Watergate impeachment scandal.
Robert Mueller and his squad of Hillary Clinton lawyers interviewed 500 people. John Dean wasn't on Mueller's witness list because he knows nothing about this. And he shouldn't be on Nadler's witness list either.
Unfortunately, his appearance yesterday tells you everything you need to know about where Democrats are headed.
In God We Trust
Atheist Michael Newdow struck out again in his crusade to purge faith from the public square. Newdow made headlines in 2004 arguing that the Pledge of Allegiance was unconstitutional because it contains the words "under God." He lost.
He has also sued to prevent presidents from saying, "So help me God" in the oath of office during their inaugurations. He lost those cases too.
And yesterday the Supreme Court rejected Newdow's latest argument that "In God We Trust" on our currency is unconstitutional.
China Protests
There were massive demonstrations in Hong Kong Sunday. Perhaps as many as 1 million people took to the streets to protest a new extradition law allowing communist Chinese authorities to seize human rights activists in Hong Kong and put them on trial elsewhere in the country.
The resistance, coming so soon on the heels of the Tiananmen Square anniversary, is encouraging. And I wonder if it would be this bold if they did not see America's president standing up to mainland China as well.
The demonstrations underscore the tremendous problems China is grappling with, and President Trump could be much more effective in negotiations if our elites were not constantly apologizing for China and lobbying on its behalf.
For example, a senior executive from the Chamber of Commerce was on CNBC today excoriating President Trump for his stance against communist China. Trump called into the network this morning and took on the national Chamber of Commerce. Here's what he said:
"I'm a member of the U.S. Chamber and maybe I'll have to rethink that because, when you look at it, the Chamber is probably more for the companies … than they are for our country…
"The China deal is going to work out. You know why? Because of tariffs. China is getting absolutely decimated by companies that are leaving China, going to other countries, including our own, because they don't want to pay the tariffs."
There is a great irony here. The Chamber opposes American leftists who want to overregulate business, but it defends communist China, which makes all kinds of outrageous demands on companies trying to do business there, while our jobs are shipped overseas and U.S. communities are hollowed out.


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Master Sewing and Design Certification Program
Sunday, June 24, 2012
Sunday Night Reflections
This Heartwarming Video Will Restore Your Faith in Humanity! from littlejoey on GodTube.
When we look at a statue of someone great, we think they've got something we don't. We are trained to think that only a tiny percentage of us have the stuff it takes to be a hero. Not many of us will cure any diseases or slay any dragons, but every single one of us.....every single one of us, is called to be a king, a queen, a hero in our ordinary lives. We don't build statues to worship the exceptional life, we build them to remind ourselves what IS possible in our own.
Author Unknown
We who lived in concentration camps can remember the men who walked through the huts comforting others, giving away their last piece of bread. They may have been few in number, but they offer sufficient proof that everything can be taken away from a man but one thing: the last of the human freedoms.....to choose one's attitude in any given set of circumstances.
Victor Frankel
Posted by RhondaBuss at 9:22 PM
Labels: Sunday Night Reflections
3 comments:
Thanks for the great video It gives me something to think about and a good example of what I should do It is easy to forget Thanks again for sharing!!ReplyDelete
Thanks for sharing this great video sometimes I forget when life and stress takes over after viewing this I realize I need to try harder Thanks againReplyDelete
That was a heart warmer. ;-)ReplyDelete
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The design of the History Faculty building was an entry into an architectural competition in 1963. The winning design was conceived by James Frazer Stirling and the resultant structure is almost identical to the original plans. However, after the competition, it was discovered that a part of the original site was unavailable to the University and the building was turned 90 degrees to fit the land available. The building was completed in 1968 and awarded a Royal Institute of British Architects Gold Medal in 1970. The building is listed by English Heritage.
"The building was the subject of a limited competition and, apart from changes in siting, is almost the same as the original project. It was necessary to provide multi-directional approaches in the History Faculty. To allow for different cross-campus circulation routes four entrances have been provided, two of which are at ground level. At the front of the building there is also an approach by ramp to the staff entrance."
James Stirling, Michael Wilford and Associates. James Stirling, Buildings and Projects. p97.
Architecturally, Stirling's Faculty building arouses great interest, and visitors come from all over the world to view it; so many in fact, that the times during which they can actually come into the library itself (the central focus of the building) has to be restricted.


text: Phytoestrogens and Related Food Components in the Prevention of Cancer 99-112 10.1615/CritRevEukaryotGeneExpr.2017019473 Muhammad Imran Qadir Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Bosan Road, Multan, Pakistan Bushra Nawaz Cheema Faculty of Pharmaceutical Sciences, Government College University, Faisalabad, Pakistan phytoestrogen lignan cancer-fighting food Great progress has been made in the fight against disease in many different fields of medicine, especially in the field of natural medicine. Phytoestrogens and related compounds play a major role in the prevention and treatment of cancer. Chemoprevention, a narrative approach for controlling cancer, involves the use of specific natural products or synthetic chemical agents to overturn, repress, or prevent pre-malignancy before the development of invasive cancer. Several natural products confer protective effects against a wide range of cancers; examples include grains, nuts, cereals, spices, fruits, vegetables, beverages, medicinal plants, herbs, and their various phytochemical constituents including phenolics, flavonoids, carotenoids, and nitrogen-containing and organosulfur compounds. Phytoestrogens and related compounds act by different mechanisms that ultimately provide benefit with minimum or no side effects and protect and treat different types of cancer, including liver, lung, colon, breast, prostate, esophagus, oral, intestinal, and many other carcinomas.


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Pol Roger are huge supporters of the practise of Blind Wine tasting, and support a number of competitions where the discipline is put to the test, the longest standing being the Varsity match, now in its 63rd year, and the youngest, the Inter WSTA, which was launched in 2015. The Inter Brewers' match was established in 2002 and is held every other year in the majestic setting of the Brewers' Hall in the City.
This year, we were delighted to be joined by 6 teams from the Brewing industry, including Wiltshire family brewery Arkell's, whose Chairman, James Arkell, is the current Master of the Worshipful Company of Brewers.
The match followed the same format as the Inter-Regional WSTA and Business School Alumni Blind Wine-Tastings, with 4 white, followed by 4 red wines served blind and answers selected from multiple choice options. With a mixture of old and new world wines, the selection took the tasters around the globe and tested their knowledge of some lesser known regions (perhaps slightly cruel was a Sauvignon Blanc from Côtes de Gascogne in France!).
It was a closely fought contest however, proving unmatchable on the reds, Young & Co claimed victory for the very first time and all team members were awarded a bottle of Pol Roger Brut Vintage 2004.
We look forward to returning to Brewers' Hall in two years time for the next clash of the Brewers!


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Adrenal Fatigue
Home \ Conditions Treated \ Naturopathy \ Adrenal Fatigue
Adrenal Fatigue - What is it and how do I test for it?Adrenal fatigue is becoming more and more common within our society. With more pressures and less downtime (and even when we do have downtime, we're often looking at some sort of screen) and the constant need to be "on the go", your adrenal glands may start to be affected. At Empowered Health one in two people we see have some sort of stress that relates to their presenting symptom. You are not alone. Many people describe it as not having the energy to get through their daily activities. Everything in their life slows down. Natural therapies may offer a safe and effective way for treating your adrenal glands*. So if you are thinking about trying a natural approach for your fatigue, then read on as we may be able to help you regain your energy and strength to do the things that you want to be doing.
*Disclaimer: Please know that the results are a typical and may vary from person to person
What Is Adrenal Fatigue?
The condition is also known as Hypoadrenia. "Hypo" meaning lower and "Adrenia" relating to the adrenals. Here we are not talking about Addison's Disease, but instead, low cortisol, adrenalin and DHEA. Your adrenal glands are finely tuned to respond to physical, emotional or psychological stress. When these stresses happen long term, it can deplete the adrenals, causing a lowered output of these hormones, particularly cortisol. This can result in not being able to cope with stress as much as you used to.
How can I tell if I have Adrenal Fatigue?
Some of the symptoms that you may experience can include:
- Tired all the time
- Salt and/or Sugar cravings
- Not waking refreshed in the mornings
- Difficulty sleeping
- Energy picks up at night, even though you've been tired all day
- Using coffee and sugar as a "pick me up"
- Difficulty handling stressful situations
- Feeling down
- Difficulty doing every day task
Always see your fully qualified healthcare professional if you are experiencing these symptoms.
How would I get Adrenal Fatigue?
Generally, it is caused by long term stress. Often we are 'on the go' all the time. If you've said, "there's not enough hours in the day " one too many times, then it's time to start thinking about your adrenals. They are supporting you, but in long term they deplete the hormones that are released that help you to keep going, namely cortisol (and also DHEA-s). If we go back to caveman days, our adrenal glands were to be used in short-sharp bursts to run from the lion. In many situations we are "running" to get things done every day, not just when we see the lion, on occasion. Adrenal Fatigue is usually related to long - term stress; whether it's physical, emotional, psychological, environmental, infectious illness or a combination of all of these.
Some of the experiences of long term stress can include:
- Long work hours for extended periods of time
- Lots of deadlines at work
- Bullying at school or in the workplace
- Being a long term carer for someone who's ill
- Not eating a diet high in vegetables, protein (plant or animal) and healthy grains. (ie. Eating alot of processed foods).
- An emotional upset - death of a loved one, relationship break up, change in financial circumstance
- Feeling like you have to be "on the go" all the time
Are you feeling overwhelmed? stressed? And not able to cope as well as you used to?
This condition can leave you with feelings of not being able to cope with even the simplest upset. Even if you can still work, it might take all your effort to get there and you can become teary or angry quite easily. Normally, you might be happy to listen to peoples problems or help solve work issues, but right now, you just want it all to go away.
How can Naturopathy help me if I have Adrenal Fatigue?
People who suffer from this condirtion often have had long term stress. That's where working with a naturopath comes into it. We help you to nourish your adrenal glands through eating the right foods. We also help you to help get you back on track quicker by using specific supplements to support, rebuild and focus on your adrenal glands. Along with this, we work with you to help you establish new boundaries to help bring balance into your life so you can do the things that you want to be doing.
How does a Naturopath test for Adrenal Fatigue?
We also use Saliva Hormone Testing to help confirm what's happening with your adrenals. We find this more accurate than a blood test for measuring your cortisol levels. Cortisol is a stress hormone, which increases when you're stressed. Many people who have a blood test can get stressed and this will increase cortisol levels and can give a false positive. Testing cortisol via saliva is less invasive and stressful and therefore gives a better picture of what your cortisol levels are doing.
About Andrea, resident Naturopath at Empowered Health, specialising in Adrenal Fatigue
Andrea Strand has been a practising naturopath for over 10 years and helps many people who have adrenal fatigue. Want to chat to Andrea to see if taking this path is right for you? Call us for a free 5 minute phone briefing or book an consultation on 1300 21 44 25. We look forward to seeing you soon!
Want to feel healthy again?
Book in for a Consultation at Empowered Health!


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"Thank you so much for getting my mum walking in Bromley again through your reflexology. All the very best for the New Year - you are an excellent reflexologist."
Jasmine P. 02/12/16
"I have known Jane for many years but have only been back in touch with her recently. I was delighted to find that she was a Reiki Master as she was able to help me with a current health problem. Her professionalism and calm persona inspires and soothes leaving you feeling energised and positive after just one hour session.
I highly recommend Jane and her treatments."
Nikki 04/04/15
" Although initially sceptical, I decided to try Reiki with Jane in order to combat a very painful attack of gout. The session took me into what I can only describe as `another realm`. Walking had been almost impossible, but the day after the initial session the pain (and swelling) had reduced to such an extent that walking was possible. Another treatment gave another significant improvement. I will certainly visiting Jane again for further Reiki. "
Nick 20/05/14
"Fantastic! I have been seeing Jane for a while now, mostly for Reiki and Facial Massage. Jane provides a calm and relaxing atmosphere for her treatments and is a very calm and gentle person, who discusses thoroughly with you what the benefits are and your reasons for treatment. Highly professional, Jane is a Reiki Master. Jane has treated me for, headaches, back pain, stress and each time I come away relaxed, calm and my problems relieved. I highly recommend Jane and her treatments."
Reviewed By Sue Matthews on 5th June 2012


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Black wool blend mini tube skirt from Alaïa Pre-Owned featuring a high waist, a stretch fit and a pull-on style. Circa 1990. Please be mindful that this piece has led a previous life, and may tell its story through minor imperfection. Purchasing this item continues its narrative, so you can be confident that you're making a POSITIVELY CONSCIOUS choice for the planet.
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Designer Style ID: ALA320A
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Apr 17 2014 ok glass (finally got my hands on one)
I just bought a 2012 Burton TWC Pro. The M6 transition kit allows fitting your older Burton binding (mine was 2005) on Burton's new boards featuring The Channel (or ICS – Infinite Channel System).
Click image to Play Video
In the process of upgrading my home network, I've just picked – a new NAS, Netgear ReadyNAS Duo, with 1.5TB+1.5TB disks in x-raid configuration (netgear's raid1 with dynamic exapansion); this is replacing my older Maxtor Shared Storage II – a fanless CPU/Motherboard, Intel D510MO with Intel's next-gen Pine Trail Atom processor, as my (always-on) mini-itx Continue reading
Okay, packing up some gear for a 6 days vacation in Paris next week!! 😉 We rented a beautiful apartment 5m walk to Eiffel tower. We're visiting most of the popular attractions that this beautiful city has to offer.. Montmartre, the Latin quarter, La Conciergerie, Notre Dame, Arc de Triomphe, a boat tour of the Continue reading
Jun 25 update: bathtub video test 😉 For the coming summer season I just bought this cheap waterproof (5m/15ft) case: the Aquapac 404. For less than 30€, the 404 is small enough to fit my Vado HD camcorder, my mobile phone (does 3G work for some Qik realtime streaming underwater ?!?) or my p&s camera. Continue reading
taken on Sun, 31 May 2009 10:20:32am (CEST) [ NIKON D300; 50 mm @ f/1.8 @ 1/250th @ 200 ISO ; metering: Manual, Center-weighted average ]
I've been drooling over this expensive Nikon pro-grade fixed f/2.8 zoom lens for a while and I finally got one. First impressions: stellar wide open performance at all focal lengths as promised, nice pleasant bokeh, focus fast even in dim light, beautiful color rendition and contrast, tack sharp. The only cons so far is the Continue reading
This gadget is the new Creative Vado HD. I just got one in the mail today 🙂 It has excellent HD (H.264 / 720p30 / 8.5Mbps) video quality for the price ($200), and most online services (FB, YouTube, Vimeo, etc) are finally hosting HD videos! Google returns tens of reviews about it vs its two Continue reading
Just got a Solmeta N1+ gps for my D300 – Camera phone upload powered by ShoZu
I got the 80-200 f/2.8 AF D. This pro level lens has excellent bokeh and is tack sharp at any aperture but shows way more color fringing than the cheaper 70-300VR I've been using for the last couple of years. – Camera phone upload powered by Shozu


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The girls and boys to whom this edition of The State of the World's Children is dedicated are not problems. Rather, each is a sister, brother or friend, a daughter or son with dreams and the desire to fulfill them; a child with a disability who has the same rights as any other girl or boy.
Given opportunities to flourish, children with disabilities have the potential to lead fulfilling lives and contribute to the vitality of their communities. Yet surviving and thriving can be especially difficult for them.
Children with disabilities are at greater risk of being poor and often face additional social barriers than their peers. In many countries, support for children with disabilities is largely limited to institutionalization, abandonment or neglect. These responses are the problem, and they are rooted in negative assumptions and ignorance.
What we need is a commitment to these children, their rights and their futures. We need to give priority to the most disadvantaged for the benefit of all.
Reaching every child
As part of the UN, UNICEF works tirelessly to help children and their families wherever they are. We work to ensure government policy and practices provide children, including children with disabilities with health care and vaccinations, clean water, nutrition, education, protection and more. We aim to reach all children, whether separated by distance or discrimination because nowhere is too far to go to help a child.
We can be proud that Canada was amongst the first signatories of the Convention on the Rights of Persons with Disabilities. We encourage Canada to not only fully implement the Convention at home, but to use its influence to ensure the Convention is ratified and implemented around the world.
We can also be proud that Canada's foreign aid includes a focus on children and together we're making sure more children than ever before survive and thrive. But children living with disabilities often find themselves excluded from the progress Canada is making with its partners around the world. It is in the best interest of these children and Canada to make sure they are not excluded, no matter how hard it is to reach them.
Visit the State of the World's Children Website site to learn more >


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Decks, steps and rails are the most frequent painting project for homeowners and businesses, occurring as a yearly to bi-annual chore for heavy traffic areas and every three to four years for normal usage.
These areas are painted frequently because:
- They are a very visible part of any home or business where significant time is spent
- These areas have significant wear as high traffic areas
- These areas have the highest failure rate of any painted area on a home or business this is due to wear and the type of structure being highly susceptible to moisture failures.
Elite Trade Painting can paint and stain your decks, steps and rails. We employ proper preparation and painting techniques to ensure your deck,steps and rails look good and have the durability to last.


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Food for thought.
This clip is talking about the big picture – global economy, however it got me thinking about Nigeria economy and how all round development has stalled in the last decades.
In Nigeria, power is concentrated in the hands of few people in all regions, most of whom put us in the misery in the first place.


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- a system for communication by telegraph, heliograph, etc., in which long and short sounds, light flashes, etc., are used to symbolize the content of a message: Morse code.
- a system used for brevity or secrecy of communication, in which arbitrarily chosen words, letters, or symbols are assigned definite meanings.
- any set of standards set forth and enforced by a local government agency for the protection of public safety, health, etc., as in the structural safety of buildings (building code), health requirements for plumbing, ventilation, etc. (sanitary code or health code), and the specifications for fire escapes or exits (fire code).
- a systematically arranged collection or compendium of laws, rules, or regulations.
- any authoritative, general, systematic, and written statement of the legal rules and principles applicable in a given legal order to one or more broad areas of life.
- a word, letter, number, or other symbol used in a code system to mark, represent, or identify something: The code on the label shows the date of manufacture.
- Digital Technology.
- a set of symbols that can be interpreted by a computer or piece of software: binary code; Java code; ASCII code.
- the symbolic arrangement of statements or instructions in a computer program, or the set of instructions in such a program: That program took 3000 lines of code.
- any system or collection of rules and regulations: a gentleman's code of behavior.
- Medicine/Medical. a directive or alert to a hospital team assigned to emergency resuscitation of patients.
- Genetics. genetic code.
- Linguistics.
- the system of rules shared by the participants in an act of communication, making possible the transmission and interpretation of messages.
- (in sociolinguistic theory) one of two distinct styles of language use that differ in degree of explicitness and are sometimes thought to be correlated with differences in social class.Compare elaborated code, restricted code.
verb (used with object), cod·ed, cod·ing.
- to translate (a message) into a code; encode.
- to categorize or identify by assigning a code to: All specimens were coded prior to the test.
- to arrange or enter (laws or statutes) in a code.
- Digital Technology. to write code for (a computer program or application) (often followed by up): Hire a programmer to code up a website for you.
verb (used without object), cod·ed, cod·ing.
- Genetics. to specify the amino acid sequence of a protein by the sequence of nucleotides comprising the gene for that protein: a gene that codes for the production of insulin.
- Digital Technology. to write computer code.
- a system of letters or symbols, and rules for their association by means of which information can be represented or communicated for reasons of secrecy, brevity, etcbinary code; Morse code See also genetic code
- a message in code
- a symbol used in a code
- a conventionalized set of principles, rules, or expectationsa code of behaviour
- a system of letters or digits used for identification or selection purposes
verb (tr)
- to translate, transmit, or arrange into a code
c.1300, "systematic compilation of laws," from Old French code "system of laws, law-book" (13c.), from Latin codex, earlier caudex "book, book of laws," literally "tree trunk," hence, book made up of wooden tablets covered with wax for writing. Meaning "cipher" (the sense in secret code) is from 1808.
1815, from code (n.). Specifically in the computer sense from 1947. Related: Coded; coding.
- A system of signals used to represent letters or numbers in transmitting messages.
- The instructions in a computer program. Instructions written by a programmer in a programming language are often called source code. Instructions that have been converted into machine language that the computer understands are called machine code or executable code. See also programming language.
A series of instructions designed to be fed into a computer.


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The Linux Programmer's Toolbox helps you tap into the vast collection of open source tools available for GNU/Linux. Author John Fusco systematically describes the most useful tools available on most GNU/Linux distributions using concise examples that you can easily modify to meet your needs.
You'll start by learning the basics of downloading, building, and installing open source projects. You'll then learn how open source tools are distributed, and what to look for to avoid wasting time on projects that aren't ready for you. Next, you'll learn the ins and outs of building your own projects. Fusco also demonstrates what to look for in a text editor, and may even show you a few new tricks in your favorite text editor.
You'll enhance your knowledge of the Linux kernel by learning how it interacts with your software. Fusco walks you through the fundamentals of the Linux kernel with simple, thought-provoking examples that illustrate the principles behind the operating system. Then he shows you how to put this knowledge to use with more advanced tools. He focuses on how to interpret output from tools like sar, vmstat, valgrind, strace, and apply it to your application; how to take advantage of various programming APIs to develop your own tools; and how to write code that monitors itself.
Next, Fusco covers tools that help you enhance the performance of your software. He explains the principles behind today's multicore CPUs and demonstrates how to squeeze the most performance from these systems. Finally, you'll learn tools and techniques to debug your code under any circumstances.
Coverage includes


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Ok, so the article is actually called "12 things Microsoft does better than Apple."
Let's see if Matt Weinberger says anything with merit or if he's just trying to save his job by mentioning the word "Apple" and being a hit-whore.
As you may guess from its name, Windows handles application windows better than Apple OS X. In Windows 10, just drag an open window to the top of the screen to full-screen it, or to the side to make it fill half the screen. It's handy for multitasking.
– Windows does not handle windows better than Mac. Mac has been doing it 10 years longer and 10 years better in almost every way. In fact, what little Matty here doesn't realize is that Windows, especially in its early days, couldn't do multiple windows for a single app. Instead, there needed to be one giant parent window, and that parent window could then have multiple children windows move around in it. Today, Windows FAKES multiple Windows per app by typically running multiple instances of the same app. Now, that little rant aside of Matt's lack of Windows knowledge, he IS right about the split screen. Split screen is simply done better on Microsoft's side. Drag and snap. When you're done, drag and unsnap. OS X (as of El Capitan) can also do split screen but, unfortunately, Apple took a page from Microsoft's usual playbook and it's a bit wonkier to do than Microsoft's (who seemingly stole from Apple's usual playbook). Pressing and holding the green button on a window will let you do split-window mode.https://support.apple.com/en-us/HT204948
Unlike Apple's Siri, Microsoft's Cortana learns a noticeable amount from your preferences. Even better, Cortana is available from the Windows 10 task bar or on iPhone and Android. Siri is stuck on the iPhone and iPad, without Mac OS X integration.
– This may or may not be true. I use Siri sparingly on my phone, so it's not like I depend on it much. Maybe Cortana is better, but I haven't found myself using it on Windows 10 yet, so it can't be that amazing. Siri is coming to Mac, supposedly, but who gives a crap. Score for Microsoft for having it, but not sure it makes anything better.
Apple's OS X hasn't changed much over the last several years. But from Windows 7 to 8 to 10, Microsoft has removed, re-added, and gussied up its Start menu. Now you can find files and apps faster and get key information without opening up the app.
– So, you're telling me, Windows users only acknowledge something is different or new or fancy if you change the outward appearance? Not surprising. One of Windows users' main problems with Macs is that they cannot theme the OS to look like a clown car. So, it's not surprising to me that Windows users don't understand under-the-hood changes as real change and, if Microsoft doesn't change to a new "Fisher Price" theme with each Windows iteration, the users are in pure disbelief. Another thing that Matt demonstrates here and something I've accused Windows users of is the following.
- In Windows 8, the Metro/Modern apps were full screen. There were no windowed apps (I thought Windows handled windows better, Matt).
- In Windows 8, the Start menu was removed and replaced with some Start screen with tiles. More crap.
- In Windows 10, the claim to fame was: windowed-windows (you know, what windows are supposed to do) and the return of the Start menu. So, for Windows users, change means SEEING it. We don't have to change anything under the hood. Make it disappear for an iteration. Bring it back. And the WOW starts because Windows users are fucking stupid.
Oh, and the "key information you can get without opening up the app" pales in comparison to Quick Look, which still hands Microsoft its ass. Sorry, Matt. You show your need for a new book cover without ever reading the first page to see if the book has changed or improved.
Windows has always been a better place for gaming than the Mac. With Windows 10, Microsoft doubled up on that with a new Xbox app that literally lets you stream games from the Xbox One console to your Windows 10 laptop, tablet, or PC.
– Legitimate. Mac definitely has more games than it used to, but is still behind Windows in the amount of titles.
Microsoft is better at cloud services than Apple. With apps like OneNote and OneDrive, you can have your files and notes anywhere at any time — not just on Apple devices.
– Microsoft may have more apps across platforms that use the cloud, but that doesn't make them better at cloud. It just means they have more apps that use the cloud, which is separate from Windows itself. In fact, many iCloud things can be accessed and edited on any platform by using the icloud.com. Well, to be precise, the (formerly known as) iWork suite (Pages, Numbers, Keynote) can be edited from anywhere. I'm sure Apple could make Pages for Windows and then it would "make OS X better than Windows" in Matt's eyes because of an Apple app working on Windows. Logic lost here.
Microsoft's hardware business has been pretty great at rethinking what a computer is and who it's for. The Microsoft Surface Book, a combination tablet and laptop, for example, has enough horsepower to play most marquee games.
– I have yet to hear any actual users of the Surface praise it. Look! It's a book. Now it's a tablet. Now it's a laptop. Now it's a door stop. Oh, but it still needs anti-virus. Still corrupts itself. Still loads temporary profiles. Still has a really shitty track pad. If that's Microsoft's idea of high quality, then they've been high quality for decades.
In fact, Apple more or less copied the Surface Pro 4 tablet with its own iPad Pro. But where the iPad Pro runs a version of Apple iOS, meaning you get only a limited selection of apps, the Surface Pro 4 is all Windows all the time.
– It's unlikely that the iPad Pro was an after-thought rushed to market to face the stiff (Hahahahaha! maybe with Viagra) competition from the Surface. The iPad Pro was meant to simply be bigger, faster, and responsive to a 3D touch Pencil. I'm not sure I agree with the iPad Pro, but I'd take that over a Windows anything device any day.
And while Microsoft has all but lost the smartphone market to Apple and Google, don't discount some of the stuff that Windows 10 Mobile has that the iPhone doesn't. First, it has a slick look, with big easy-to-push buttons …
– My grandmom's old apartment phone had big, easy-to-push buttons also. Didn't make the phone slick or better than anything on the market. Oh, and notice Matty's default appreciation for anything Windows. Well, it LOOKS different. Remember, Windows users only acknowledge an OS has some sort of change if it's visual. Take it away. Bring it back. Make buttons bigger. WOW!!!11 LOOOK HOw DIFFErent IT IS NOW!!11111
.. plus some nifty, if still a gimmicky, features like Windows Continuum, which lets you use your Windows 10 Mobile phone as something like a full PC. With limited app support, but still.
– Now you're just reaching, Matty. Samsung Galaxy Phones let you wave your finger in front of the camera to scroll like you're a Harry Potter wizard, but there's nothing good about it. Little Matty is proving he likes spec-sheets. Wow. Let me know how that "full PC functionality on a phone" works out for you. Just because it CAN do it doesn't mean it SHOULD or it any good. Scoring a point for this just makes you look like an idiot.
The Microsoft of the last few years has also been better at experimentation. That includes coming out with lots of experimental apps for Android and iPhone, including the recent Hub Keyboard, which cuts down on the time you have to switch between apps.
– Experimentation doesn't equal better. No denying that Microsoft is better under this new CEO than the monkey known as Ballmer, but nothing it has released for Android or Apple makes it inherently better than Apple. This is pure opinion on your part, not fact.
That experimentation also applies to advanced scientific research. Microsoft Research contributes findings to everything from speech recognition to artificial intelligence. Plus, it results in cool futuristic technologies like the HoloLens holographic goggles.
– Just because Microsoft touts its experimentations publicly doesn't make it better than Apple. After all, remember all the Glassholes that were excited about Google Glass? Where is that now? Just because experiments are public doesn't mean it's better. Again, more opinion on your part. No actual fact here that makes Microsoft better.
In general, Microsoft has been good at playing with others recently. Under CEO Satya Nadella, Microsoft has made more of its apps available on more platforms, while simultaneously striking deals with one-time competitors like Red Hat.
– Microsoft has always played well with others… until it pulled the rug out from those other players. Time will tell if they do that now. Microsoft making something for Red Hat doesn't make it better than Apple. Again, this is just Matty Opinion, not fact or evidence.
In the end, Matt really only offers a lot of opinions and nonsense, either purposely leaving out info or simply doesn't know enough to actually write this article in the first place.
Beating a dead horse because I can:
- Windows still blue screens, despite Windows fans saying it no longer does.
- Windows still gets drive-by web infections, despite claims of "built-in antivirus," which is nothing more than Windows Defender included.
- Windows still corrupts itself, causing temporary profiles as well as other registry anomalies.
- Windows boxes still have the worst track pads on the market.
- Windows boxes still come with shitty Pentium, Celeron, and Core i3 chips, which all perform like a snail but, hey, it's $199.
Expect shit from Windows. Doesn't matter if you mold that shit to look like a work of art. It will still stink up your house and draw flies.


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As you begin planning wedding entertainment, you'll find prices varying wildly from hobbyists or beginners for less than $500 to respected and seasoned professional DJs for more than $2000. Fast food will get you fed cheaply but do you want fast food at your wedding? The best steak house in town (experienced DJ) is certainly more expensive but it provides quality and expert service more representative of an important occasion such as a wedding.
The minimum expectation for DJs is alarmingly low. "Do you have two speakers? Great! You're hired!" Sadly, the public has resigned itself to low quality with a shrug and a remark that "It's just the way DJs are." Not so.
Take the time to interview 2 or 3 DJs. Lean on the recommendations of other professionals that you trust. Your venue, photographer and caterer have worked with DJs who are brilliant. Find a DJ who is passionate about the craft and loves music and people. You don't have to pick every song in that initial consultation, but you do need to decide if you like him or her and if you trust them to do the event. If you find a vendor that you like, book them. To be booked a year at a time is not uncommon.
A few base line expectations: Arrive and be ready to work on time. Provide adequate equipment for the occasion and the space and know how to use it. DJ and staff behave well and are respectful. Play the correct songs for the elements of the event.
Sadly, some hobbyist DJs don't even arrive at this lowest line.Great entertainment adds the following: The DJ understands and represents religious, ethnic and family traditions with confidence and respect. Avoids cheesy, clichéd, overused, outdated or off-colored songs, jokes, gags or games. No microphone noise or dead air. Important songs are cued and on time. Family names are known and pronounced correctly. Wires and road cases and any other unsightly equipment is put away or covered. Doesn't say or do anything that draws attention to difficult event situations. Background music is just under the volume of the talking. Works in concert with other event professionals on site. In advance of the event, he or she returns calls and other correspondence promptly and during the event responds to instructions courteously. Music represents the tastes of the bride and groom and yet other generations, ethnicities and tastes are included. Customer knows exactly what equipment and services to expect and the cost. Lighting is colorful and adds body and motion but it's not shining in the faces of the guests or making the room spin. He or she is well-spoken and classy.


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Studies have shown a correlation between the expression of exportin 1 (XPO1) in the nuclear export system and with progression from Monoclonal Gammopathy of Undetermined Significance (MGUS) to Smoldering Multiple Myeloma (SMM), and finally to active MM. Data from a phase I study indicated efficacy of selinexor against a number of hematologic malignancies, including MM, both alone and in combination with low-dose dexamethasone. Most of the patients in phase I trial had heavily pretreated myeloma, Non-Hodgkin Lymphoma (NHL) and, Acute Myeloid Leukemia (AML).
Dan T. Vogl, from the Division of Hematology and Oncology, University of Pennsylvania, US, and colleagues, set out to expand these findings in a study in which selinexor and low-dose dexamethasone was used to treat patients refractory to all of the most effective and currently available anti-myeloma agents. This phase II trial was published in the Journal of Clinical Oncology in January 2018.
Patients with measurable disease based on International Myeloma Working Group (IMWG) guidelines and who had been treated with at least three prior anti-myeloma regimens, including an alkylating agent, glucocorticoids, bortezomib, carfilzomib, lenalidomide, and pomalidomide were included in this study. Patients were disease-refractory to their most recent regimen, as well as refractory to bortezomib, carfilzomib, lenalidomide, and pomalidomide, either alone or in combination. This study also included a subset of patients who were disease refractory to an anti-CD38 monoclonal antibody. The primary endpoint was overall response rate (ORR).
Study Design
- Patients (pts) were administered 80-mg of oral selinexor, twice weekly, on days 1, 3, 8, 10, 15, 17, 22, and 24 of each 28-day cycle (six doses for 83% of the patients with quad-refractory myeloma and eight doses for 65% of the patients with penta-refractory disease), with no treatment-free intervals (TFI)
- 20mg dexamethasone was given with each dose of selinexor
- A 5-hydroxytryptamine-3 antagonist (ondansetron 8mg or equivalent) was given to all pts before the first dose of selinexor, 2-3 times daily, as required
Key Findings:
- N = 79 patients (pts); safety dataset = 78 pts; quad-refractory myeloma = 48 pts; penta-refractory myeloma = 31 pts
- Median age = 63 years
- Median time from diagnosis = 4 years (range <1–35)
- Median number of prior regimens = 7 (range 3–17)
- All pts received glucocorticoid therapy; prior alkylating agents = 97%, prior anthracyclines = 41%, autologous stem-cell transplantation (ASCT) = 77%
- High-risk abnormalities (which include del(17p), t(4;14) and t(14;16)) = 44%
- ORR = 21% (95%CI, 13–31%); pts with high-risk cytogenetic abnormalities = 35%
- ORR for pts with quad-refractory (bortezomib, carfilzomib, lenalidomide and pomalidomide) diseases = 21%
- ORR for pts with penta-refractory (bortezomib, carfilzomib, lenalidomide, pomalidomide and anti-CD38 antibody) diseases = 20%
- Median duration of response = 5 months; responding pts alive at 12 months = 65%
- Clinical benefit rate (CBR) = 33% (95%Cl, 24–44)
- VGPR = 5% (median duration = 5 months)
- PR = 15% (median duration = 5 months)
- Minimal response (MR) = 13%
- Stable disease (SD) = 35%; median duration = 2 months (0.9–7.6)
- Progressive disease (PD) = 27%
- Median PFS = 2.3 months
- Median OS = 9.3 months
- Pts who achieved ≥ a minimal response after one cycle of therapy vs stable or progressive disease: median OS = not reached vs 7.2 months, P = 0.01
- Non-hematologic treatment-related Adverse Events (AEs):
- Grade 3 and 4: fatigue (15%), nausea (8%), and diarrhea (5%)
- Grade 3 hyponatremia reported in 22% of pts but reversible with supportive care
- Hematologic AEs (grade 3 or 4):
- Thrombocytopenia (59%), anemia (28%), neutropenia (23%) and leukopenia (15%)
- Bleeding = 2 pts (3%), febrile neutropenia = 1 pt, infection = 14 pts
- No differences in toxicity between pts who received 6 or 8 doses per cycle
- Serious AEs = 22 (possibly related to study treatment = 19/22 pts)
- Dose interruptions for AEs = 41 pts (52%), dose reductions = 29 pts (37%), and treatment discontinuation = 14 pts (18%)
This study indicated the beneficial use of combining selinexor with low-dose dexamethasone displaying an ORR of 21% in heavily pretreated MM patients who are refractory to many of the commonly used therapies. Higher response rates were associated with the use of low-dose dexamethasone, in comparison to selinexor alone. The overall survival rate was also improved when compared to historical controls. A future phase II trial is now planned, in which 122 patients with penta-refractory myeloma will be enrolled.


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Left-wing Press Never Stops Whingeing
The UK press ran almost twice as many article on issues that were negative for Labour as were positive, according to an utterly pointless Loughborough University study published by the (who else?) Guardian. The study tells us that 682 articles focused on issues negative for Ed Miliband compared with 358 that were positive while the Conservatives had 614 that were positive for the party compared to 502 that were negative..Headline for Guardian piece: "Labour gets almost half as much positive press coverage as Tories". What on earth are they trying to prove here. That Miliband's unpopular brand of socialism got more criticism than Cameron's free market capitalism? The voters showed us that Labour were less popular, why should this not have been reflected in the press? Much more significant would be have been for the study to have pointed out that the Tories got nearly as many negative comments as they did positive, thus achieving a near perfect balance that reflected the voting patterns of society at large. Once again, the left-wing press and university luvvies seek to tailor statistics they even created themselves to try to show themselves at a media disadvantage. My puzzlement is why Miliband even reached 358 articles that were positive in a thoroughly off-message campaign that managed to hit almost every single available false political note. Whinge, whinge whinge, we woz robbed, cry the Milipeed fan club. The electorate didn't understand us. OMG, move on mate, the bus has left the depot and there won't be another along for at least five years, thank God.


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7520 Royal St 526, Park City
Empire Residences presents a rare combination of location, design, layouts, and features never before combined within a single property - direct ski access, expansive outdoor decks with private hot tubs, innovative through-building floor plans, and a signature design by Alder & Tweed. Whether entertaining in your living room, or relaxing in the hot tub, you will enjoy breathtaking views of the ski runs of Deer Valley, the twinkling lights of Silver Lake Village, and the distant snow capped peaks of the Uinta Mountains. This amenity-rich mountain lodge includes a front lobby with concierge desk, apres-ski fireside lounge and pub, fitness center, ski locker room, ski beach patio with outdoor fire pits, underground parking with private storage, and a live-in Lodgekeeper. Empire Residences will set a new standard for slopeside luxury living.
Sewer: Connected, Sewer: Public, Water: Connected, Gas: Connected, Power: Connected
Hot Tub, Microwave, Range, Range Hood, Refrigerator, Washer, Dryer
Closet: Walk-In, Den/Office, Dishwasher: Built-In, Disposal, Oven: Wall, Range: Gas, Vaulted Ceilings, Granite Countertops, Bar: Wet
Sidewalks, Terrain: Mountain, View: Mountain, View: Water
Summit Sotheby's International Realty - Park City
Information deemed reliable but not guaranteed accurate. Buyer to verify all information.
The multiple listing information is provided by Wasatch Front Regional Multiple Listing Service, Inc. from a copyrighted compilation of listings. The compilation of listings and each individual listing are © 2020 Wasatch Front Regional Multiple Listing Service, Inc., All Rights Reserved.
The information provided is for consumers' personal, non-commercial use and may not be used for any purpose other than to identify prospective properties consumers may be interested in purchasing.
Listing information last updated on June 7th, 2020 at 2:20am MDT.


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Items where Division is "03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Children's Hospital > Pediatric Immunology (Holländer)"
Number of items at this level: 37.
Teh, Hong Ying. Role of polycomb repressive complex 2 in thymic epithelial development and function. 2017, Doctoral Thesis, University of Basel, Faculty of Science.
Mayer, C. E. and Zuklys, S. and Zhanybekova, S. and Ohigashi, I. and Teh, H. Y. and Sansom, S. N. and Shikama-Dorn, N. and Hafen, K. and Macaulay, I. C. and Deadman, M. E. and Ponting, C. P. and Takahama, Y. and Hollander, G. A.. (2016) Dynamic spatio-temporal contribution of single beta5t+ cortical epithelial precursors to the thymus medulla. Eur J Immunol, 46 (4). pp. 846-856.
Zuklys, S. and Handel, A. and Zhanybekova, S. and Govani, F. and Keller, M. and Maio, S. and Mayer, C. E. and Teh, H. Y. and Hafen, K. and Gallone, G. and Barthlott, T. and Ponting, C. P. and Hollander, G. A.. (2016) Foxn1 regulates key target genes essential for T cell development in postnatal thymic epithelial cells. Nat Immunol, 17 (10). pp. 1206-1215.
Barthlott, Thomas and Bosch, Angela J. and Berkemeier, Caroline and Nogales-Cadenas, Rubén and Jeker, Lukas T. and Keller, Marcel P. and Pascual-Montano, Alberto and Hollander, Georg A.. (2015) A subpopulation of CD103(pos) ICOS(pos) Treg cells occurs at high frequency in lymphopenic mice and represents a lymph node specific differentiation stage. European Journal of Immunology, 45 (6). pp. 1760-1771.
Bosch, Angela Jeanne Tamara. The role of the transcription factor Foxn1 in Thymus organogenesis and maintenance. 2014, Doctoral Thesis, University of Basel, Faculty of Science.
Dertschnig, Simone. Breakdown of thymic tolerance - an etiologic link between acute and chronic graft-versus-host disease. 2014, Doctoral Thesis, University of Basel, Faculty of Science.
Sansom, Stephen N. and Shikama-Dorn, Noriko and Zhanybekova, Saule and Nusspaumer, Gretel and Macaulay, Iain C. and Deadman, Mary E. and Heger, Andreas and Ponting, Chris P. and Holländer, Georg A.. (2014) Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia. Genome Research, 24 (12). pp. 1918-1931.
Berkemeier, Caroline. The role of mTOR for the development and function of mouse thymic epithelium. 2013, Doctoral Thesis, University of Basel, Faculty of Science.
Krenger, Werner and Blazar, Bruce R. and Holländer, Georg A.. (2011) Thymic T-cell development in allogeneic stem cell transplantation. Blood : the journal of the American Society of Hematology, Vol. 117, H. 25. pp. 6768-6776.
Lei, Y. and Ripen, A. M. and Ishimaru, N. and Ohigashi, I. and Nagasawa, T. and Jeker, L. T. and Bosl, M. R. and Hollander, G. A. and Hayashi, Y. and Malefyt Rde, W. and Nitta, T. and Takahama, Y.. (2011) Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development. Journal of experimental medicine, Vol. 208, H. 2. pp. 383-394.
Papadopoulou, Aikaterini S. and Dooley, James and Linterman, Michelle A. and Pierson, Wim and Ucar, Olga and Kyewski, Bruno and Zuklys, Saulius and Hollander, Georg A. and Matthys, Patrick and Gray, Daniel H. D. and De Strooper, Bart and Liston, Adrian. (2011) The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor. Nature Immunology, Vol. 13, H. 2. pp. 181-187.
Thakar, Saurabh and Chandra, Preeti and Hollander, Gerald and Lichstein, Edgar. (2011) Electrocardiographic changes in takotsubo cardiomyopathy. Pace, Vol. 34, H. 10. pp. 1278-1282.
Fayard, Elisabeth and Moncayo, Gerald and Hemmings, Brian A. and Holländer, Georg A.. (2010) Phosphatidylinositol 3-kinase signaling in thymocytes : the need for stringent control. Science signaling, Vol. 3, H. 135 , re5.
Gossens, Klaus and Naus, Silvia and Holländer, Georg A. and Ziltener, Hermann J.. (2010) Deficiency of the metalloproteinase-disintegrin ADAM8 is associated with thymic hyper-cellularity. PLoS ONE, Vol. 5, H. 9 , e12766.
Holländer, Georg A. and Krenger, Werner and Blazar, Bruce R.. (2010) Emerging strategies to boost thymic function. Current opinion in pharmacology, Vol. 10, H. 4. pp. 443-453.
Irla, Magali and Hollander, Georg and Reith, Walter. (2010) Control of central self-tolerance induction by autoreactive CD4+ thymocytes. Trends in immunology, Vol. 31, H. 2. pp. 71-79.
Kelly, Ryan M. and Goren, Emily M. and Taylor, Patricia A. and Mueller, Scott N. and Stefanski, Heather E. and Osborn, Mark J. and Scott, Hamish S. and Komarova, Elena A. and Gudkov, Andrei V. and Holländer, Georg A. and Blazar, Bruce R.. (2010) Short-term inhibition of p53 combined with keratinocyte growth factor improves thymic epithelial cell recovery and enhances T-cell reconstitution after murine bone marrow transplantation. Blood, Vol. 115, H. 5. pp. 1088-1097.
Kenins, Linda and Gill, Jason W. and Holländer, Georg A. and Wodnar-Filipowicz, Aleksandra. (2010) Flt3 ligand-receptor interaction is important for maintenance of early thymic progenitor numbers in steady-state thymopoiesis. European Journal of Immunology, Vol. 40, H. 1. pp. 81-90.
Krenger, Werner and Holländer, Georg A.. (2010) The role of the thymus in allogeneic hematopoietic stem cell transplantation. Swiss medical weekly, Vol. 140 , w13051.
Saade, Murielle and Irla, Magali and Yammine, Miriam and Boulanger, Nicolas and Victorero, Geneviève and Vincentelli, Renaud and Penninger, Josef M. and Holländer, Georg A. and Chauvet, Sophie and Nguyen, Catherine. (2010) Spatial (Tbata) expression in mature medullary thymic epithelial cells. European Journal of Immunology, Vol. 40, H. 2. pp. 530-538.
Vroegindeweij, Eric and Crobach, Stijn and Itoi, Manami and Satoh, Rumi and Zuklys, Saulius and Happe, Christiane and Germeraad, Wilfred T. V. and Cornelissen, Jan J. and Cupedo, Tom and Holländer, Georg A. and Kawamoto, Hiroshi and van Ewijk, Willem. (2010) Thymic cysts originate from Foxn1 positive thymic medullary epithelium. Molecular immunology, Vol. 47, H. 5. pp. 1106-1113.
Holländer, G. A. and Peterson, P.. (2009) Learning to be tolerant : how T cells keep out of trouble. Journal of internal medicine, Vol. 265, H. 5. pp. 541-561.
Shikama, Noriko and Nusspaumer, Gretel and Holländer, Georg A.. (2009) Clearing the AIRE : on the pathophysiological basis of the autoimmune polyendocrinopathy syndrome type-1. Endocrinology and metabolism clinics of North America, Vol. 38, H. 2 , S. 273-288, vii.
Takahama, Yousuke and Saito, Takashi and Kawamoto, Hiroshi and Itoi, Manami and Boyd, Richard L. and Chidgey, Ann and Zamoyska, Rose and Holländer, Georg A. and Anderson, Graham and Taylor, Naomi and Petrie, Howard T. and Nikolich-Zugich, Janko. (2009) The Global Thymus Network: past, present and future. Trends in immunology, Vol. 30, H. 5. pp. 191-192.
Zuklys, Saulius and Gill, Jason and Keller, Marcel P. and Hauri-Hohl, Mathias and Zhanybekova, Saule and Balciunaite, Gina and Na, Kyung-Jae and Jeker, Lukas T. and Hafen, Katrin and Tsukamoto, Noriyuki and Amagai, Takashi and Taketo, Makoto M. and Krenger, Werner and Holländer, Georg A.. (2009) Stabilized beta-catenin in thymic epithelial cells blocks thymus development and function. Journal of immunology : official journal of the American Association of Immunologists, Vol. 182. pp. 2997-3007.
Alimohammadi, M. and Björklund, P. and Hallgren, A. and Pöntynen, N. and Szinnai, G. and Shikama, N. and Keller, M. P. and Ekwall, O. and Kinkel, S. A. and Husebye, E. S. and Gustafsson, J. and Rorsman, F. and Peltonen, L. and Betterle, C. and Perheentupa, J. and Akerström, G. and Westin, G. and Scott, H. S. and Holländer, G. A. and Kämpe, O.. (2008) Autoimmune polyendocrine syndrome type 1 and NALP5, a parathyroid autoantigen. The New England journal of medicine, Vol. 358, H. 10. pp. 1018-1028.
Guimond, M. and Leonard, W. J. and Spolski, R. and Rossi, S. W. and Veenstra, R. G. and Hollander, G. A. and Mackall, C. L. and Blazar, B. R.. (2008) Thymic stromal lymphopoietin is not necessary or sufficient to mediate the thymopoietic effects of keratinocyte growth factor. Blood, Vol. 111, H. 2. pp. 969-970.
Heikenwalder, M. and Prinz, M. and Zeller, N. and Lang, K. S. and Junt, T. and Rossi, S. and Tumanov, A. and Schmidt, H. and Priller, J. and Flatz, L. and Rülicke, T. and Macpherson, A. J. and Holländer, G. A. and Nedospasov, S. A. and Aguzzi, A.. (2008) Overexpression of lymphotoxin in T cells induces fulminant thymic involution. American Journal of Pathology, Vol. 172, no. 6. pp. 1555-1570.
Holländer, G. A.. (2008) Lymphoid reconstitution following hematopoietic stem cell transplantation : of mice and men: progress made in HSCT immunobiology. Seminars in immunopathology, Vol. 30, no. 4. pp. 369-370.
Hozumi, K. and Mailhos, C. and Negishi, N. and Hirano, K. and Yahata, T. and Ando, K. and Zuklys, S. and Holländer, G. A. and Shima, D. T. and Habu, S.. (2008) Delta-like 4 is indispensable in thymic environment specific for T cell development. Journal of experimental medicine, Vol. 205, H. 11. pp. 2507-2513.
Irla, M. and Hugues, S. and Gill, J. and Nitta, T. and Hikosaka, Y. and Williams, I. R. and Hubert, F. X. and Scott, H. S. and Takahama, Y. and Holländer, G. A. and Reith, W.. (2008) Autoantigen-specific interactions with CD4+ thymocytes control mature medullary thymic epithelial cell cellularity. Immunity, Vol. 29, H. 3. pp. 451-463.
Kenins, L. and Gill, J. W. and Boyd, R. L. and Holländer, G. A. and Wodnar-Filipowicz, A.. (2008) Intrathymic expression of Flt3 ligand enhances thymic recovery after irradiation. Journal of experimental medicine, Vol. 205, H. 3. pp. 523-531.
Krenger, W. and Holländer, G. A.. (2008) The immunopathology of thymic GVHD. Seminars in immunopathology, Vol. 30, no. 4. pp. 439-456.
Krenger, W. and Holländer, G. A.. (2008) The thymus in GVHD pathophysiology. Best practice & research. Clinical haematology, Vol. 21, H. 2. pp. 119-128.
Jeker, Lukas Thabo. On the role of "aire" and "smad4" in thymic development. 2006, Doctoral Thesis, University of Basel, Faculty of Science.
Mathieu, Yves D.. Identification of novel genes involved in the commitment of endodermal cells to the thymic epithelial cell fate. 2006, Doctoral Thesis, University of Basel, Faculty of Science.
Peduzzi, Elisabetta Martina. Monitoring of human cellular immune responses in infectious diseases : malaria vaccine associated responses and immune characterization of Buruli ulcer patients. 2006, Doctoral Thesis, University of Basel, Faculty of Science.


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Red Ice Radio, interview by Henrik Palmgren (December 2008) - theduderinok's archive - - Alternative Egyptologist and Author John Anthony West comes on the program to talk about his research and work into ancient Egypt and the current financial turmoil. He is the author of Serpent in the Sky: The High Wisdom of Ancient Egypt, The Traveler's Key to Ancient Egypt, and The Mystery of the Sphinx. He is also behind the DVD series Magical Egypt. We discuss what the ancient science of the Egyptians can offer us today, we discuss how the current financial turmoil is connected to the ancient world. We talk about John's background and how he got interested in Ancient Egypt. Topics Discussed: Great Sphinx of Giza, Water Erosion on The Sphinx, Dating of the Sphinx, Paleoclimatology, Robert Schoch, R. A. Schwaller de Lubicz, Temple of Man, The Financial Crisis, Materialism, "The Church of Progress", Enlightenment, Gerald Celente, Gurdjieff, Astrology. www.redicecreations.com
Audio Interviews
S-Docs © 2012 https://starvethesystem.webnode.com/


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I created this card for the SCCSC2 sketch challenge on Stampin Connection.
The card base is Rich Razzleberry and the panel in the back on the right is Pink Pirouette CS(retired)with some Rich Razzleberry DSP (retired). The top panel is more Rich Razzleberry and Pink Pirouette CS.
You can't tell in the picture but "MOM" is stamped on shimmery white cardstock and then the letters are colored in with various shades of pink. I also pulled out some of my Pretty in Pink epoxy brads (in the occasions mini) and some of the flowers from Flower Fusion 1 (retired), as well as some silver hodgepodge hardware to embellish this card. I used the set Vintage Labels (from the Sale-a-Bration brochure) with some Rich Razzleberry and Rose Red ink.
Stamps: Messages for Mom, Vintage Labels
Cardstock: Shimmery White, Rich Razzleberry, Pink Pirouette
Paper: Raspberry Tart DSP
Ink: Black, Rose Red, Pretty in Pink, Positively Pink, Rich Razzleberry
Accessories: Pretty in Pink epoxy brads, Silver Hodgepodge Hardware, Flower Fusion 1 flowers.


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8:57am PT by Michael O'Connell
TV Ratings: 'Bachelorette' Rises, 'Under the Dome' Wins, 'Siberia' Sinks
ABC took Monday night thanks to a rising Bachelorette. The series pulled a 2.3 rating with adults 18-49, rising four-tenths of a point from last week. Mistresses (1.3 adults) was also up by a tenth, giving the network a nightly average of a 2.0 rating with adults 18-49 and 6.56 million viewers.
Under the Dome (2.7 adults), down a tenth of a point from last week, and encores brought CBS second-place status in both key measures -- with a 1.7 adults rating and 6.51 million viewers for the night.
PHOTOS: 51 Summer Series
American Ninja Warrior (1.5 adults) was down a tenth of a point on NBC, while Get Out Alive (1.2 adults) was down two-tenths. Siberia (0.7 adults) was also down by a tenth. NBC pulled a 1.1 rating with adults 18-49 and 3.6 million viewers.
Encores brought a 0.5 rating with adults 18-49 and 1.5 million viewers for Fox, while The CW earned a 0.2 adults rating and 725,000 viewers.
Univision averaged a 1.3 rating with adults 18-49 and 3.3 million viewers, and Telemundo had a 0.7 adults rating and 1.6 million viewers.
Michael email@example.com mikeylikestv


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TEES, built at Goole for E.P. Hutchinson of Hull. She was 546gt, completed November 1911, and in 1923 passed to New Zealand owners without change of name. In August 1940 she was sold within New Zealand to become the HOLMWOOD. On 25 November 1941 she was on her normal route from Chatham Island to Lyttelton when she was intercepted and sunk by the German armed merchant cruiser KOMET. Crew and passengers were landed on an island and later rescued by another NZ ship. Despite being a small vessel she had accommodation for 20 passengers in small cabins amidships and a further 12 in bunks aft.
See also: http://www.gooleships.co.uk/goolesb/tees1911.htm
Photo from TEESSHIPS archives, origin unknown, but contributed by Dave Martin: Ron


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|Ellie on her first day at school
I learnt pretty quickly that I need to provide a snack as soon as Ellie gets in the door or things go downhill pretty quickly. Apples are devoured in minutes, bananas in seconds and I can't chop the grapes fast enough. She's having a good breakfast too and hot lunches and then often two plates of dinner. I had forgotten what hungry work school was.


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SCRAMBLER bike yobs caused chaos at a family fun day in Seaforth, assaulting a teenage volunteer and threatening people - forcing the event to close early.
The annual event was in full swing at Bowersdale Park on Saturday, August 3 when four youths on two scrambler bikes arrived at around 2pm and drove into the park where hundreds of people had gathered.
An 18-year-old volunteer, who was helping children have pony rides, was punched and kicked to the ground by one of the yobs.
Organisers from Friends of Bowersdale Park decided to close the event early as a precaution.
A spokesperson for Shy Lowen Horse and Pony Sanctuary, who had organised the pony rides for children, said: "A teenage girl was holding a child on our pony Holly at the wonderful family event when she was attacked.
"He beat our girl with his fists and kicked her. She was brave and did everything she could to protect the child and the pony. People advanced to protect her and he rode off."
The event featured stalls, children's games and other activities for local families to enjoy.
A spokesperson for Friends of Bowersdale Park said: "Thanks so much to everyone who attended the fun day.
"It was a fantastic day and sorry we had to close the event because of an issue which was beyond our control.
"Everyone's safety is always our priority and we are all gutted."
Police have launched an investigation into the incident.
Chief Inspector Paul Sutcliffe said: "This has left people of all ages shocked and disappointed, and we are determined to find those responsible.
Continued inside
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"Witnesses are being spoken to and CCTV opportunities are being looked into."
He added that reports of the anti-social and nuisance use of off-road motorbikes have decreased significantly across Merseyside in the last 18 months, and that thay had worked with local authorities, schools, youth groups, housing associations, and communities affected to keep scramblers off our streets, with great success.
But he said incidents like this are "an unwelcome reminder that people are still affected by the reckless riding, noise and associated crime brought about by their illegal use."
Anyone with information is asked to message @MerPolCC, or @CrimestoppersUK on 0800 555 111.


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Just today I received a mail from a traumatised girl who has been dieting for years with no return! Here is a section from her mail:
'Hi Bryan,
I have been dieting for years over 20 and still look the same 5'4, 120lbs, 23% bodyfat yes i admit i have tried it all tons of cardio intervals, weight training, low carb, low fat, high protein, carb cycling etc. Maybe I lose two pounds but then it just comes right back. . . .'
I immediately responded with an elongated version of the following article as I know how frustrating it can be when you think you are doing everything right but there may be one tweak here, or a little change there that could make the difference. There's always something. I know you would like to think you are unique and that you cant lose weight, or 'it's genetic, so it's not my fault'. Granted, it is harder for some people to lose weight than others and some people put on weight easier! Well that's just too bad, we are all unique. BUT, that doesn't mean its not possible! You are not special in this regard, you can lose weight, and achieve the body you want but you may just have to work a little harder that's all!
There is a process involved. You must address you lifestyle, not just your diet 3 days per week! You must change the way you approach losing weight. It is not something you have to 'achieve' it is your new lifestyle! Deal with it and adopt an 'athletic mindset'. Athletes do not just take up a sport and hope to be champion in their discipline in 12 weeks, they adopt a lifestyle, set long term goals and ultimately they achieve something.
Setting goals like 'lose weight' or 'gain muscle' do not make sense. They are superficial. Set goals that are rewarding and not just a number on a weighing scales or measuring tape. Set visual goals, i.e. 'How do I want to LOOK in 6 months time?' Or performance goals: 'I want to improve all my lifts in the gym'. These are a lot more measurable and more realistic and easier to follow.


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Dorrington House 24hr Helpline
Getting access to care is going to be harder over the next 18 months. If you have any problems or need more information contact: Dorrington House directly.
Pressure to find and fund a bed during discharge from Hospital
Can I still have an assessment even if I am a self funder? Yes you can! However you will have to fund your care, but you decide on the Carehome.
For further advice, call 07775-614200 or e-mail email@example.com anytime 24/7
Social Services or your local County Councillor. Details are listed on their website www.norfolk.gov.uk and go to Adult Services or Councillors and type in your post code.
You can always e-mail us if you are not sure, email: firstname.lastname@example.com


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This page last reviewed May 28, 2015
Energy Efficiency and Co-Benefits Assessment for Large Industrial Sources - Public DocumentsOn July 22, 2010, the Air Resources Board (ARB) approved the Energy Efficiency and Co-Benefit Assessment of Large Industrial Facilities (EEA Regulation). The regulation was approved by the Office of Administrative Law and became effective on July 16, 2011. The regulation required the largest industrial sources in California to conduct a one-time assessment of fuel and energy consumption, and emissions of greenhouse gas, criteria pollutants, and toxic air contaminants. Affected facilities were also required to identify potential improvements in equipment, processes, or systems that could result in energy savings.
Phase 1: Develop Industrial Sector Public Reports
ARB staff is developing five separate Public Reports compiling the
information provided by the facilities subject to the EEA Regulation.
The table below identifies the five Public
Reports and the release date for those reports that have been released.
|Public Report
|Release Date
|Public Workshop
|Refinery Sector
Errata Sheet
|June 6, 2013
|July 9, 2013
|Cement Sector
|August 26, 2013
|June 30, 2015
|Hydrogen Sector
|July 30, 2014
|Oil and Gas Production / Mineral Production
|July 30, 2014
|Electricity Generation Sector
|April 24, 2015
- Each Public Report is composed of three main parts: Introduction and Summary, Part I, and Part II.
" Part I" is a sector-wide summary of all of the energy efficiency
improvement projects identified by all of the reporting facilities. In
addition to a brief description of the project, estimates for
greenhouse gas, criteria, and toxics pollutant emission reductions and
cost information, as reported by the facilities are included. These
data are aggregated in a manner to be consistent with the public
disclosure requirements under California Code of Regulations (CCR)
"Part II" summarizes refinery-specific information as reported by the facility, again aggregated in manner consistent with the public disclosure requirements under CCR §95610.
- To develop the Public Reports, ARB staff reviewed the information provided to ensure that it fully met the requirements of the EEA Regulation, conducted field visits of affected sources to better understand the equipment and processes, and contacted facilities for clarification or to request additional information.
- A Draft Public Report was provided to all the facilities in the sector for their review and comment. Each facility received the Executive Summary and Part I and the Part II summary for their facility only. This was done to ensure that the report accurately reflected the information provided by the facility and ensure that we were not disclosing information that the facility believes is confidential business information.
- A public meeting is tentatively scheduled on June 30, 2015, to receive comments on the Public Reports and suggestions on how to proceed with the following program phases, Phase 2 and 3.
Phase 2: Develop ARB Findings Report
- ARB staff is conducting a comprehensive review of the reported data, comparing projects across sectors and evaluating them against other available information, including the Department of Energy Industrial Technologies Program Best Practices.
- ARB staff will prepare a draft report with preliminary findings and recommendations covering all of the sectors. Stakeholder meeting(s) on the Public Report will be used to receive initial input on how ARB staff might proceed. This draft report will be used as a starting point for discussion with all stakeholders on what actions and approaches could be taken to maximize on-site greenhouse gas, criteria, and toxic pollutants emission reductions.
This draft report will include the results from the third-party review of a subset of the facility reported data. This third-party review is being conducted by the Industrial Assessment Center of San Francisco State University.
- We anticipate releasing the draft report in the fall of 2015 and holding a public workshop to receive comments and guidance on Phase 3 of the program.
- The
ARB Findings Report will be used as a starting point for discussion
with all stakeholders on what actions and approaches could be taken to
maximize on-site greenhouse gas, criteria, and toxic pollutants
emission reductions.