text:
Hand Painted Silk Butterfly Mumu (Fushia)101208
Hand Painted Silk Butterfly Mumu (Fushia)
Product Code: 101208
- 100% Silk
- Dry Clean Only
- Pure Chinese silk MuMu (mid-length)
- Lightweight, smooth, supple, lustrous sheen
- Measuring approx. 54in Bust / 48in Waist / 31.5in Length
- Chinese Mandarin Collar, Loose Large Sleeve, Low Slit On Both Side
Price INCLUDES SHIPPING worldwide by registered air parcel post. Delivery usually takes 10-12 days, sometimes longer around Christmas. Please order early.
Customer Service
We're Here To Help
Your satisfaction is important to us! Use the form below to email us your questions about products, online orders, store experiences and more.
Order Questions:
If you need help or have any other questions concerning your orders, please fill out the form or call: +852 2463 8156 or +852 2735-3037.
GPO Box 6083
Central, Hong Kong 00000 HK
Phone: +852 2463 8156 or +852 2735-3037 Email: email@example.com
(Please note time in Hong Kong is 12-13 hours in advance of U.S Eastern Standard Time depending on the time of the year. There may be a delay, therefore, in replying to your email.)
The local time in Hong Kong is 12: AM
Other items you might like


text:
If you have a question or a comment. We read all.
Company name, website, what you think of doing with Airtop, anything else you want us to know.
Anti spam question. See slogan on main page title. Please type in lowercase.
Airtop online shop now details price, shipping and tax (per country).
Please visit Airtop online shop for more details.

subset: commoncrawl


text:
This guy right here is Ryan Field. He is not to be confused with Ryan Field, the football stadium for the Northwestern Wildcats. Field is the sideline "reporter" for Fox Sports Detroit, and during last night's Detroit-NOOCH game, he "reported" on a flood in the NOOCH locker room.
Now, we've all seen a million sideline "reporters" out there, and experience tells us that anytime one of those guys is handed news that has the word "flood" and "Hornets" in the same sentence, well, it's a recipe for disaster.
Sure enough, foot met mouth, as Field compared the flood to the hurricane in New Orleans, saying "the Hornets having to leave their locker room in the same way they had to leave New Orleans after Hurricane Katrina." To be fair, he resisted making a joke that commissioner David Stern was woefully late it coming to rescue them, so that was nice.
Ryan Field Must Have Rocked His SAT's [Mickey Tettelton Memorial Overpass]


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Home / Party Wear Lehenga / Exclusive Orange Designer Lehenga Choli with Fusion
Shop from a wide range of beautiful Digital print Lehenga cholis from Fashion Vibes. This designer lehenga comes with Silk fabric choli and matching chiffon dupatta .
This lehenga bears a sophisticated look and enhances the beauty of the women which can be worn for functions, festivals, and parties. You will be a center of attraction in the event when you wear it.
This fusion lehenga choli is attractive to the touch and used for evening wear, historical and stage costumes.
Perfect for a bride for own wedding function and wedding ceremony.
Pair this piece with heels or flats and matching jewelry for a stunning look.Details:
- Digital print Lehenga made of Banglori satin silk with inner
- Silk Blouse/Choli/Crop Top
- Skirt fits up to 40waist and 40 length
- Size: 38+6 margin choli
- Matching chiffon dupatta
- It is a Combo of lehenga and crop top
FV Code: AYM


text:
Answers with Acupuncture
Oriental Medicine pulse diagnosis
We accept No Fault Insurance
Oriental Medicine pulse diagnosis
We accept No Fault Insurance
Acupuncture is less expensive than western medicine. Finding the cause of your illness and treating you can cost much less. An acupuncture diagnosis does not require expensive examinations such as blood tests, X-rays, CAT scans, MRIs and special tests. When diagnosing you, acupuncturists observe, ask, listen, and feel your pulsation & diagnose your tongue. This kind of acupuncture diagnosis saves money and time.
Acupuncture is very effective at controlling any kind of pain. Most acute pains, like headache, neck & shoulder pain, arm related pain, lower back pain, and ankle pain, can be cured within three treatments. Chronic pain requires a longer time than acute pain, and it may take two to four times longer depending on the duration of your chronic pain.
Acupuncture and herb treatment has fewer side effects than western treatment because acupuncture uses natural methods. Most medicines are from chemicals, but our acupuncture and herbal treatments are all natural. We human beings come from nature. Our body cells understand natural herbs better than chemicals. When our cells are faced with chemicals, they are confused how to handle them. I believe this is the cause of side effects.
Everyone is naturally born with weak and strong organs according to a famous Korean practitioner. The principle of acupuncture is to make a balance between weak and strong organs by using tonification and sedation.
Western medicine is like spear attacking disease and eastern medicine is like a shield defending the body by building a strong immune system. When patients get surgery or chemical treatments with western medicine, our acupuncture and herbal treatments often reduce side effects and reduce the recovery period substantially.
With acupuncture, and especially with Korean Four Needle Acupuncture, it is possible to successfully treat cases that are difficult to treat with western medicine. Sometimes a patient has pains and other symptoms, and western medicine cannot find the cause, so the western doctor only treats the symptom. We can find the original cause of illness as we look at the inter relation and balance or imbalance between organs. Believe me, this is very important concept that can handle unsolved cases.
Many think all acupuncturists are equal, but is this true? Maybe not. Do you know the difference between managers? Some are good and some are excellent. When they have written tests, their scores are almost the same. This means no difference in knowledge. However the real difference shows up when important decisions are required in a split second. This ability to make the correct split second decision may be an instinct. This principle will apply to the acupuncture field. I do believe that I have the healing instinct, making possible for me to do what helps my patients heal faster while other don't notice.
Read my excellent results treating back pain, stiff arthritic fingers, fungus on toenails, insomnia, enlarged prostate, and Bells palsy.
Easy parking is available.
Answers with Acupuncture
69-27 Juno Street
Forest Hills, NY 11375
Answers with Acupuncture
69-27 Juno Street
Forest Hills, NY 11375
Answers with Acupuncture for any pains, discomforts and diseases such as stiff arthritic fingers, fungus toenails, insomnia, low back pain, prostate, bells palsy. Korean 4 needle acupuncture a speciality.
Answers with Acupuncture is located in Forest Hills, Queens, NY
Answers with Acupuncture is convenient to Rego Park, Middle Village, Glendale, Woodhaven, Richmond Hill, Ozone Park, Jamaica, Howard Beach, Bayside, Kew Gardens, Corona, Cypress, Flushing, and Ridgewood.
Easy parking.
We accept No Fault Insurance


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On August 31st, 2019 the 6th Night 4F Praski Half Marathon will take place in Warsaw. At 8:30 p.m. a few thousand runners will again set off on a fast and flat route, the leading main arteries of the Praga Południe. Warsaw at sunset, a brisk summer evening, decreasing temperature and fast route is ideal for running! A flat route marked out to promote good results and setting personal best is already the tradition of the Praski event – the biggest night race in Warsaw that has permanently entered the calendar of street runs. The date of the event is not accidental – a half-marathon conducted on an approved route (in the international master class) for many of the participants is a general test before the Warsaw Marathon in September or the Berlin Marathon, and for runners who finished April Orlen Warsaw Marathon a good test at a shorter distance.
Again the Praski Half Marathon will be accompanied by 4F Praska Five.
Registration for both runs is ongoing.
The Praski Half Marathon is held from 2014 (in 2014-2017 as BMW Praski Half Marathon, and from the 2018 edition, the titular sponsor is Polish sports brand 4F).


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I am extremely lazy when it comes to going to salons. Yes, I go for threading and hair spas but I rarely book appointments for facials. It takes way too long and I get very impatient. For people like me, a home facial kit is ideal. I can use one at my own convenience and there are zero hassles. I recently tried out the Jovees Anti-Ageing Facial Value Kit at home couple of times and liked the results. Read on to know my thoughts on the product.
Jovees Anti-Ageing Facial Value Kit Description
Our Anti-Ageing skin care facial helps stimulate the production of collagen thus mitigating and removing fine lines & wrinkles. This kit is loaded with antioxidants, which reduces the production of free radicals in the body and thus prevents aging.
This exclusive kit has six products and each product has been carefully developed using herbs and plant extracts. The kit contains the following products:
- Citrus and Blackberry Cleanser
- Apricot and Almond Facial Scrub
- Wheatgerm with Vitamin-E Face Massage Cream
- Witch Hazel and Basil Skin Toning Gel
- Sandal, Saffron and Honey Anti-Ageing Face Pack
- Almond and Ginseng Moisturising Anti-Ageing Skin Cream
Price – Rs 667
Availability – Jovees website
A mini version of the kit is also available. It includes the cleanser, scrub, face massage cream, face mask and essence of saffron anti pigmentation blemish cream. The Jovees Anti Ageing Mini Facial Value Kit is priced at Rs 225.


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In the last blog entry we saw how the basic BI EE and Essbase connecitivity works. Now, lets try to understand this in detail further. Lets start with understanding how the aggregation works for Essbase data sources. To begin with we shall change the level of aggregation for the Actuals Measure in the Business Model layer.
Basically, we have assigned Actuals to Level 1 of both Year as well as Markets. Leave the aggregation to the default "Aggr_External". So, our intention is that we should get the same value that we get at Level1 of Year for Actuals to all the other levels of the Year dimension. Now, lets go back to answers and create a simple report having Gen1,Year ,Gen2, Year and Actuals.
This works as expected. But typically this is not possible from Essbase alone. MDX cannot generate values which basically show different values than what is actually present inside Essbase. So, to find out how BI EE achieves this, lets take a look at the Physical query.
As you see, BI EE basically fires 2 different MDX queries and makes an in memory join to achieve the result. The MDX queries are provided below
With set [Market1] as '[Market].Generations(1).members' set [Year2] as '[Year].Generations(2).members' set [Axis1Set] as 'crossjoin ({[Market1]},{[Year2]})' select {} on columns, {[Axis1Set]} properties ANCESTOR_NAMES, GEN_NUMBER on rows from [Demo.Basic]
With set [Market1] as '[Market].Generations(1).members' set [Year1] as '[Year].Generations(1).members' select { [Scenario].[Actual] } on columns, NON EMPTY {crossjoin ({[Market1]},{[Year1]})} properties ANCESTOR_NAMES, GEN_NUMBER on rows from [Demo.Basic]
The first query above basically gets a cartesian product of Gen1, Market (remember we had set a level aggregation of Level1 for Market in Actuals) and Gen2, Year (this is what was chosen in our report). This query does not get any data. Instead it is just used as a temporary join placeholder. The output of the first query is shown below
The second query actually gets the value of Actuals for Gen1, Market and Gen1, Year (which are the levels for the Actuals measure). BI EE actually does go against the top level node rather than doing the aggregation in-memory. It is OLAP aware atleast in this regard. In the case of relational sources it would fire the group by to get to the top node value.
The result for the report is then obtained by making a cartesian product of the above 2 queries. This cartesian product is achieved in memory of BI Server. So, as much as possible try to avoid setting aggregation levels at the BMM layer. Leave them as defaults. If you are sure that your output results would be less, then use the level based aggregations.
As a next step let us try to understand what the default aggregation (Aggr_External) does. For that let us change the aggregation for Actual measure to none.
And lets test the same report as above (With Gen1 Year,Gen2, Year and Actuals measure).
This is very interesting as well. This basically provides data for all the intersections in your Essbase Cube. Try to avoid this as well whenever you are building your reports. The MDX will basically get every intersection that is possible using a cross join across all the dimensions. There are certain use cases wherein this might be useful. The MDX query is given below
With set [Accounts4] as '[Accounts].Generations(4).members' set [Market3] as '[Market].Generations(3).members' set [Product3] as '[Product].Generations(3).members' set [Year3] as '[Year].Generations(3).members' set [Axis1Set] as 'crossjoin ({[Accounts4]},crossjoin ({[Market3]},crossjoin ({[Product3]},{[Year3]})))' select {[Scenario].[Actual]} on columns, NON EMPTY {[Axis1Set]} properties ANCESTOR_NAMES, GEN_NUMBER on rows from [Demo.Basic]
Now that we have understood how the level based aggregations work lets understand how we can use MDX functions using EVALUATE to achieve some complex reports. We shall see what MDX functions are supported and how they can be used in the next blog entry.


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How does the payment of dividends of $15,000 affect the three elements of the accounting equation
(a) The following are users of financial statements.
______Customers ______Securities and Exchange Commission
______Internal Revenue Service ______Store manager
______Labor unions ______Suppliers
______Marketing manager ______Vice-president of finance
______Production supervisor
Identify the users as being either external users or internal users.
(b) The following questions could be asked by an internal user or an external user.
______Can we afford to give our employees a pay raise?
______Did the company earn a satisfactory income?
______Do we need to borrow in the near future?
______How does the company's profitability compare to other companies?
______What does it cost us to manufacture each unit produced?
______Which product should we emphasize?
______Will the company be able to pay its short-term debts?
Identify each of the questions as being more likely asked by an internal user or an external user.
(a) What is the most important output of the accounting cycle?
(b) Do all companies have an accounting cycle? Explain.
(a) What is the term used to describe the owner's equity section of a corporation?
(b) Identify the two owners' equity accounts in a corporation and indicate the purpose of each.
The document that captures the total amount of time that individual workers spend on each production job is called a
Explain the purpose of the accounts Depreciation Expense and Accumulated Depreciation.
(a) Explain the purpose of the accounts Depreciation Expense and Accumulated Depreciation.
(b) Is it customary for the balances of the two accounts to be equal?
(c) In what financial statements, if any, will each account appear?
The adjusted trial balance for Turner Company is presented in E4-8.
(a) Prepare an income statement and an owner equity statement for the year. Turner did not make any capital investments during the year.
(b) Prepare a classified balance sheet at July 31.
Willow Turenne Company had the following adjusted trial balance.
(a) Prepare closing entries at June 30, 2012.
(b) Prepare a post-closing trial balance.
Selected worksheet data for Woodny Company are presented below.
(a) Fill in the missing amounts.
(b) Prepare the adjusting entries that weremade.
Write something about yourself. No need to be fancy, just an overview.
March 2020


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In stock
Numbered and signed copy
The work Parc Event / P.P. Rubens – Gerda Bollen is contained in a slipcase, which is paperbound, embossed and lined with red silk. It contains two copperplates with the names of the well-known P.P. Rubens and the casual passser-by Gerda Bollen. Inside the upper part of the box, a photograph is inlaid underneath the silk lining, showing an old man sitting on a bench somewhere in Parc Royal, Brussels. On the back of the bench, the two same copperplates are to be seen, as reminder of the presence of P.P. Rubens and Gerda Bollen, who got together on the occasion of a fictitious event whose circumstances remain mysterious.
Copperplates and photography in a slipcaseSlipcase: 20 x 28 x 4 cm Limited edition of 8 numbered and signed copies and 4 artist's proofs Produced and published in 1992 by les Maîtres de Forme Contemporains (mfc-michèle didier) ©1992 Braco Dimitrijevic and les Maîtres de Forme Contemporains (mfc-michèle didier)
Email to a friend


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How can you be Romeo AND stay on a tight budget? In other words, how can you be cheap, yet appear to be romantic? Here are marketing expert Dr. Audrey Guskey's top 7 tips for saving money on Valentine's Day:
1. Buy Flowers from a grocery store. They keep their flowers refrigerated just like at a florist and you can save tons of money.
2. Skip the roses – they are extremely over priced for V-Day.
3. Celebrate Valentine's Day dinner on a day other than February 14th. Restaurants are so busy and they rarely offer discounts that day.
4. Set a budget and stick with it. Cheap can be satisfying!
5. Be a romantic – create memories – do fun and crazy things that don't cost a lot.
6. Make it yourself – an electronic photo album or a card sharing how you feel means more than any Hallmark card.
7. Use credit card reward points to buy the Valentine's Day gift.


text:
Census forms are printed in 57 languages (…including Tagalog, Igbo and Shona)Census forms will be printed in 57 languages – more than double the number a decade ago.
Taxpayers' money will be spent translating it into languages used by only a few thousand people in Britain – including Tagalog, Igbo, Tigrinya, Shona and Pashto, it was revealed.
Printing the forms with all the different translations will cost an estimated £50,000 – and the move has been branded 'time-consuming and bureaucratic' by critics.
Prime Minister David Cameron had pledged to cut spending on translations to encourage people to learn English.
Hotlines will also be set up to help citizens fill out the forms in the census which is going to cost £482million.
The paperwork will even be translated into Swedish and Dutch – even though almost all the native speakers in Britain are good at English, The Sun revealed.
Seven translations will be produced for different Indian languages.
Charlotte Linacre, Campaign Manager at the TaxPayers' Alliance said: 'There is not an endless pot of taxpayers' money to pay for more administration and documents to be translated in to scores of different languages.
'There is a huge cost for so much bureaucracy and time spent translating the forms, it's important that data is collected effectively but it's crucial that people who come to live and work in the UK are learning English so they can integrate.
'The Government needs to stop spending so much money on translation across the public sector, in order to relieve taxpayers of this burden.'
Languages like Igbo and Shona are spoken by millions of people round the world – although there are only believed to be a few thousand native speakers living in Britain.
Tagalog – or Filipino – is spoken by an estimated 74,000 people in the UK, there are 5,000 Tigrinya speakers and 100,000 who speak Pashto.
The forms are to be sent out to 22million homes this year.
A spokesman for Downing Street said the Labour government had decided to print the form in so many languages and it could not be reversed.
Promotion of the census costing nearly £7million will include television advertising in nine languages and dialects – Cantonese and Mandarin from China, and Gujarati, Punjabi, Urdu, Tamil, Bengali, Sylheti and Hindu from the Indian subcontinent.
Even one-person households will have to contend with 57 questions and 393 tick boxes.
A couple with four children face 272 questions and 918 tick boxes, with more to cope with if they have visitors on the census night of March 27.
People can expect to be asked how many bedrooms, bathrooms, cupboards and conservatories they have, and what central heating they use.
A question on religious belief is voluntary, but detailed information on ethnicity, colour and language spoken is not.


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I would like everyone to welcome Angela (Sango) Wright. Let's thank her for stopping by the blog and dropping some gems for everyday life we are honored to have her as our guest. Angela is the wife of Kai who we all know as Sango or even Sangobeats. Sango is a well-known producer who creates his own beats, Sango has also clocked studio time and produced for Tinashe, Bryson Tiller, and Smino, just to name a few, and even dropped a collab album with singer and fellow Seattle native Dave B in the summer of 2016.
"For a long time, I've focused and dwelt on the word "Elohim," meaning the God of creation. This word started to mean a lot to me when I was developing as an artist. I consider myself an artist/creator because I believe in my ideas and by pushing these ideas, my creation comes to life. The worst thing an artist can do is lack motivation and let their creativity go unused. I want to share ideas with other creatives and emphasis the true meaning of collaborating and uniting. Kai designed my logo and it represents one of my favorite verses in the Bible, Exodus 3:17, "I have promised to rescue you from your oppression in Egypt. I will lead you to a land flowing with milk and honey." God's promises will continue to unfold because of the obedience, discipline, and loyalty that He has placed in my heart" Angela founder of Shelohim.com
ארץ זבת חלבודבש
Ranisha: How have becoming a mother changed your life?
Angela: Being a mother is having a new life. My life is Mateo. Everything that I do now is for him and it influences him. It's amazing to see how he watches me and Kai's every move and tries to understand what we're doing and saying, so being a mother at 23 has helped me grow up a bit more and I don't think there's anything wrong with that. It's funny because while I was in labor, all of the nurses kept telling me, "Oh, you're 23? Perfect age to have a baby. Having a baby in your 20s is the best time." I always wanted to be a mother though. God put that in my heart and I've been praying about it for years and Mateo is our blessing. Mateo means "Gift from God."
Ranisha: After having the baby are you home more or do you pack the baby up and continue traveling?
Angela: To be completely honest, I didn't really travel with Kai when he was out working all over the US/rest of world. I did a few times, but man, the amount of traveling he does is exhausting, and I give him so much credit for doing what he does. I couldn't do it. I know I couldn't. It's fun, yes, but he's providing for me and Mateo and I pray for his journeys. I've always been a homebody, so after having the baby, nothing really changed except taking care of the baby obviously. I am excited to take Mateo with Kai and I whenever I do decide to travel with him.
Ranisha: I know you like cooking and feeding your family. What is your favorite meal prep? Can we get a recipe from you?
Angela: Yes! I'm Mexican, so most of the dishes I make are what I was raised with. I have to say my favorite meal is chilaquiles. Super easy to make and not stressful. This is my mom's recipe by the way!
Cut 3 juicy tomatoes in half and blend them with a cup and a half of water. Add any seasonings you like to this. I usually add cumin, salt, pepper, and chili powder. A little bit of lemon juice works too. Taste to make sure it has flavor. Grab a handful of corn tortillas and cut them into 1-inch pieces. Heat those up in a pan with olive oil until they get nice and crispy. I like mine golden brown. Cut up slices of onion and add that to the tortillas. After the tortillas and onions are getting hot and crispy, add the tomato blend that you made from earlier. Make sure the blend covers the entire pan and lets the tortillas and onions float a bit, but not too much. Turn up the heat so the tomato blend starts to boil, but not too long because you don't want the tortillas and onions to get mushy. After that, let everything simmer and the tomato blend should be thicker than before. Taste to see if there's any need for more spices, and if not, you're done. I eat the chilaquiles with mashed black beans, queso fresco, and avocado. This is more of a breakfast/brunch meal.
Ranisha: For those that don't know you are the wife of Kai who is also known as Sango. What is it like being married to a well-known producer? Have you mixed up and beats yet? I mean you have access to the beats are you giving away any?
Angela: I've known Kai before he became a well-known producer. We started dating when I was 17 and he was 19. He showed me what he loved to do and that was make music. At the beginning of our relationship, he sent me a lot of his beats and I thought it was sweet of him because the beats were named after me. We've learned a lot as a couple through his career. He was traveling a lot during school, so it was difficult for me to see him, but we made it work. Actually, God made it work. Being married to a well-known producer is no different because I see him as Kai. Not saying I don't see him as "Sango," but Kai is my husband and Sango is his job and I pray daily that God blesses him through his talent. It's funny you ask that! No, I haven't given away any beats, but I do show my friends and family what Kai has been working on.
Ranisha: Where is your favorite place in the house when you want to get away from all the noise? Have you soundproofed any walls yet?
Angela: Oh man, since we live in an apartment in south end Seattle, there's not really a place to get away from the noise, but I'll say our bedroom, haha. Kai does a good job of letting me have some "me time." I'll see him holding Mateo on his lap while he's making music. Mateo doesn't seem bothered because all he sees is the colors and movements on Kai's laptop.
Ranisha: What is it you and Sango do to find your inner kid? What keeps you young?
Angela: We game! Yes, we love gaming. We're really into Nintendo. He's really into 2K (eye roll). We have a WiiU, PlayStation 4, and a Nintendo 3DS.
Ranisha: Do you feel left out when the baby and Sango take off and do their own thing? Or are you like yes me time.
Angela: Yes, me time definitely. Most of the time, it's difficult for me to even leave the room Mateo's in because the second I stop being around him, I get emotional because I'm in constant need of holding him and kissing him. When I do really need some me time though, I'll ask Kai to take care of Teo while I read, go on Netflix/YouTube, the usual stuff.
Ranisha: I know that you are a woman of faith and scriptures mean so much to you. What is your favorite scripture that keeps you strong and moving forward? Can you share an experience on why this scripture means so much to you?
Angela: I think I go through a verse every year that means a lot to me. I'll tell you the most recent verse that has been really touching my soul lately: 1 John 4:19, "We love because He first loved us." That verse came with a lot of conviction these past few months. To be honest, it's really hard for me to love on people. I'm always skeptical of others, especially the people who try to come into Kai's life. There's a lot of negative influence out there in the world, so it's hard for me to see past people's personalities that I disagree with. The more I pushed people away, the less loving I was to myself and to my family. God spoke to me and said, "If I'm giving you new mercies and love every day, why can't you do the same to others?" Wow, that made me burst into tears. Who am I to not love others? What makes me think that they're undeserving? None of us are deserving of God's love, but He loves us anyway and He wants us to love others the way He loves us.
Ranisha: What projects are you working on? What can we look forward to?
Angela: Before Mateo was born, I would blog a wisdom post every Monday and I'm hoping I can get some time in this week to continue that!
Ranisha: I'm loving Sango Design. Do you have a favorite item you wear for comfort or all the time? Where can we find it? I'm going to be looking for mine in the mail.
Angela: Yes! Any of his North T-shirts are comfortable. Those were discontinued a while back, but I know you will love his ITCO merch that will be coming out when he goes on tour pretty soon! His designs for that are really on point.
Ranisha: What is it you want to tell the young girls who look up to you as a role model for inspiration?
Angela: I want young girls or anyone for that matter to know that there's more to life than what we see on social media. Bring your eyes up to see what's in front of you and experience the moments you have now.


text:
Student Blogs
Related Pages
Caltech . . . As It Happens
you have ever imagined what it would be like to do research at the
Large Hadron Collider or study evolution in the Galapagos Islands? Want
to see where our students' interests lie or what happens at Caltech on
weekends? The Caltech undergraduate experience is like no other. Our
students do research, play music and sports, travel the world, sample
cuisines, and have fun. Visit our student blogs to engage with current Techers about academics, adventures, and everyday life!


text:
Patent application title: USE OF BETA-1,3 (4)-ENDOGLUCANOHYDROLASE, BETA-1,3 (4)-GLUCAN, DIATOMACEOUS EARTH, MINERAL CLAY AND GLUCOMANNAN TO AUGMENT IMMUNE FUNCTION
Neil E. Forsberg (Corvallis, OR, US)
Neil E. Forsberg (Corvallis, OR, US)
Steven B. Puntenney (Ione, OR, US)
OmniGen Research, L.L.C.
IPC8 Class: AA61K3847FI
USPC Class:
424 9461
Class name: Enzyme or coenzyme containing hydrolases (3. ) (e.g., urease, lipase, asparaginase, muramidase, etc.) acting on glycosyl compound (3.2) (e.g., glycosidases lysozyme, nucleosidases, cellulase, etc.)
Publication date: 2014-01-23
Patent application number: 20140023633
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A method for the augmentation of immune function is described. The
invention comprises a combination of β-1,3 (4)-endoglucanohydrolase,
β-1,3 (4)-glucan, diatomaceous earth, mineral clay and glucomannan,
which is fed to or consumed by mammalian or avian species in amounts
sufficient to augment immune function. The invention described may be
admixed with feeds or foods, incorporated into pelleted feeds or foods or
administered orally to mammalian and avian species.
1. A method for reducing a stress effect in an animal, comprising
administering to an animal having an increased stress indicator a
composition comprising β-glucans, β-1,3
(4)-endoglucanohydrolase, silica, a mineral clay, and mannans, wherein
the animal is selected from mammalian and avian species, thereby reducing
a stress effect in the animal.
2. The method of claim 1 where the increased stress indicator is an elevated stress hormone level and the stress effect is immunosuppression mediated by the elevated stress hormone level.
3. The method of claim 2 where the elevated stress hormone is cortisol, hydrocortisone, corticosterone, or a combination thereof.
4. The method of claim 2 where the elevated stress hormone level includes elevated glucocorticoids.
5. The method of claim 1 where the composition is administered to the animal at or around a time of parturition.
6. The method of claim 1, further comprising administering the composition to the animal as a prophylactic to prevent colonization or growth of pathogenic fungal or bacterial species in the animal.
7. The method of claim 1 where administering the composition augments the animal's innate immune function.
8. The method of claim 7 where augmenting the animal's innate immune function includes increasing the expression of L-selectin, interleukin-1.beta., or a combination thereof.
9. The method of claim 1 where the silica is provided by diatomaceous earth.
10. The method of claim 1 where the mannans comprise glucomannan.
11. The method of claim 1 where the mineral clay comprises montmorillonite, bentonite, aluminosilicate, or zeolite clays, or mixtures thereof.
12. The method of claim 1 where the composition comprises from about 15% to about 40% silica, from about 50% to about 81% mineral clay, from about 1.0% to about 5.0% β-glucans, from about 0.05% to about 3.0% β-1,3 (4)-endoglucanohydrolase, and from about 1% to about 8.0% mannans.
13. The method of claim 1 where administering the composition comprises admixing the composition into foods or animal feedstuffs that are subsequently fed to the animal.
14. The method of claim 15 where the composition is admixed into the foods or animal feedstuffs in a concentration of from about 0.0125% to about 5% by weight of the foods or animal feedstuffs.
15. The method of claim 1 where administering the composition comprises feeding the composition to the animal as a supplement in an amount from about 0.016 grams/kg to about 0.37 grams/kg of live body weight per day.
16. The method of claim 1 where administering the composition comprises administering the composition to the animal in an amount from about 0.125% to about 0.5% by weight of feed.
17. The method of claim 1 where the composition is administered daily to the animal.
18. The method of claim 1 where the stress effect is susceptibility to a fungal or bacterial disease or a bacterial disease and administering the composition reduces the animal's susceptibility to the fungal or bacterial disease.
19. The method of claim 1 where the animal is a bovine, equine, ovine, caprine, or avian species.
20. A method for reducing a stress effect in an animal, comprising: identifying a stressed animal of a mammalian or avian species by determining an elevated stress hormone level; and administering to the stressed animal a composition comprising β-glucans, β-1,3 (4)-endoglucanohydrolase, silica, a mineral clay, and mannans, thereby reducing a stress effect in the animal.
[0001] This application is a continuation of U.S. application Ser. No. 13/566,433, filed Aug. 3, 2012, which is a continuation U.S. application Ser. No. 11/668,375, filed Jan. 29, 2007, now U.S. Pat. No. 8,236,303, which is a divisional of U.S. application Ser. No. 10/829,633, filed Apr. 5, 2004.
[0002] This disclosure relates to methods and compositions for the augmentation of immune function in mammalian and avian species.
[0003] The immune system consists of two general features. These are: 1) the innate immune system and 2) the adaptive (antibody-mediated) immune system. The innate system represents the first line of defense against an invading pathogen (whether bacterial or fungal) and provides the adaptive immune system with enough time (3-5 days) for it to build up antibodies which are used to "fight" pathogens. While the innate and adaptive systems are often described separately, they function in tandem; striving to sequester and neutralize a pathogen challenge.
[0004] The innate immune system. The innate immune system consists of several interesting components: Aspects include:
[0005] 1. Physical and chemical barriers to pathogens provided by epithelium, gastric acid and digestive enzymes.
[0006] 2. Cells which engulf and digest invading pathogens (e.g., neutrophils).
[0007] 3. Receptors on the surface of these cells which recognize and bind to pathogens.
[0008] 4. Signaling molecules (e.g., chemokines, cytokines) which communicate sites of infection and regulate expression of immune genes.
[0009] Neutrophils. Neutrophils are among the most important cells of the innate immune system. They are the first cell to arrive at a site of infection. In mammals, there are billions of neutrophils of which about one-half are freely circulating in the blood (Burton and Erskine, 2003). The remainder are held in reserve in bone marrow where they are formed. Neutrophils express an extracellular binding protein on their membranes termed "L-selectin" (also termed CD62L). The role of L-selectin is to interact weakly with the endothelial cell wall thereby allowing the neutrophil to "roll" along the wall of a blood vessel and to "monitor" the cell wall for the presence of signals which indicate a local infection (FIG. 1). The presence of pathogens in peripheral tissues causes release of local chemicals which then signal a rolling neutrophil of an infection. In response to these signals, L-selectin is shed from the surface of the neutrophil (see FIG. 1) and other more adhesive molecules are expressed on its surface. These molecules essentially "glue" the neutrophil within the blood vessel adjacent to the site of infection. The activated neutrophil then migrates through the endothelial cell wall toward the invading pathogen. Interleukin-1β is produced by the neutrophil as a pro-inflammatory cytokine. This aids in mediating inflammation and in facilitating containment of invading pathogens. During neutrophil migration, chemical signals originating from the site of infection (such as TNF-β and interferon γ) activate the neutrophil to become a mature "killer cell". The mature neutrophil migrates toward the site of infection where it interacts with pathogen-associated microbial patterns (PAMPs) on the surface of pathogens via several types of receptors. These receptors are expressed on the surface of the neutrophil and include the following well-identified types (FIG. 2):
[0010] a--CD18 and CD14
[0011] b--Toll-like receptors (TLRs)
[0012] c--C3b and C3bi (complement factors)
[0013] d--Fc
[0014] Binding of neutrophils to pathogens via receptors. Both CD14 and CD18 receptors bind with lipopolysaccharide (LPS), a common polysaccharide structure associated with membranes of gram-negative bacteria. In addition, neutrophils express toll-like receptors (TLRs) which recognize and bind to additional structures associated with pathogens. So far, ten different toll-like receptors have been identified in mammals (FIG. 2 and Table 1). TLRs play a critical role in early innate immunity to invading pathogens by sensing microorganisms. These evolutionarily conserved receptors recognize highly conserved structural motifs only expressed by microbial pathogens, called pathogen-associated microbial patterns (PAMPs: Invivogen, 2004). Stimulation of TLRs by PAMPs initiates a signaling cascade that involves a number of proteins, such as MyD88 and IRAK (FIG. 2). This signaling cascade leads to the activation of the transcription factor NF-kB which induces the secretion of cytokines that direct the adaptive (i.e., antibody-mediated) immune response. TLRs are predominantly expressed in tissues involved in immune function, such as spleen and peripheral blood leukocytes, as well as those exposed to the external environment such as lung and the gastrointestinal tract. Ten human and nine mouse TLRs have been characterized, seven of which have had their ligands identified. For example, TLR2 is essential for the recognition of a variety of PAMPs, including bacterial lipoproteins, peptidoglycan, and lipotechoic acids. TLR3 is implicated in virus-derived double-stranded RNA. TLR4 is predominantly activated by lipopolysaccharide. TLR5 detects bacterial flagellin and TLR9 is required for response to unmethylated CpG DNA (Table 1). Recently, TLR7 and TLR8 were shown to recognize synthetic antiviral molecules. These receptors are essential elements in host defense against pathogens by activating the innate immunity (Invivogen, 2004).
[0015] Bovine TLRs. Relatively few studies on PAMPs have been completed with bovine cells. So far, bovine immune cells have been reported to contain TLR2 and TLR4 (Werling et al., 2004). Polymorphisms have been reported in bovine TLR4 which may determine susceptibility to bovine respiratory disease and Johne's disease (White et al., 2003).
[0016] C3b and C3bi are components of the complement cascade whereas the Fc receptor binds to the "constant region" of antibodies. Hence, pathogens which are coated with complement factors or antibody (i.e., pathogens which are opsonized) are also recognized by activated neutrophils and are subsequently phagocytosed. In other words, activated neutrophils possess several means by which they recognize pathogens (Table 1).
[0017] Phagocytosis and killing. The binding of neutrophils, (and other phagocytic cells) to cell-surface markers of pathogens via these receptors, then permits the phagocytic cell to engulf the invading pathogen and "kill" it (FIG. 3). Presently, two mechanisms for "killing" are known. These include: 1) an oxidative burst, where the phagocyte expresses reactive oxygen species which destroy the phagocytosed pathogen, and 2) fusion of the engulfed pathogen with a lysosome-like structure to form a "phagosome". The phagosome is rich in digestive enzymes which mediate complete digestion of pathogens.
[0018] Common infections. Mammalian and avian species are continually challenged by pathogens in the gastrointestinal track and in the lung. These are important sites for resident neutrophils where minimize pathogen invasion. In addition, the mammary gland of mammals represents a site for pathogen challenge. In all infections, the innate immune system plays a key initial role in fighting-off the initial immune challenge. The innate system is essential to allow the adaptive (antibody-mediated) system to develop and mount a more-specific and directed immune response.
[0019] Cooperation between the innate and acquired immune system in ruminants. Antibodies which are specific to an invading pathogen leak into a site of infection to optimize clearance of a pathogen. Individuals with a high titer against a specific antigen are able to deliver these antibodies into the site of infection via a leaky endothelium (arising from an inflammatory response). Arrival of reactive antibodies (i.e., IgG2) in the alveolus coats (opsonizes) the pathogen and, as noted previously, allows neutrophil recognition of pathogens via Fc receptors (Table 1) and phagocytosis.
[0020] Stress and immune function. Stress reduces individuals' abilities to fight disease. The negative effects of stress on the immune system are mediate by the steroidal stress hormones (Cortisol, hydrocortisone and corticosterone). Burton and co-workers at Michigan State University (Weber et al., 2001) have identified the mechanism by which stress brings about a reduction in immune function. Specifically, they have documented that glucocorticoids (i.e., cortisol) "spike" near parturition (FIG. 4) and reduce L-selectin expression in neutrophils (FIG. 5). This compromises one important aspect of an individual's first line-of-defense against pathogen challenge. Specifically, a stressed, immunosuppressed individual has reduced ability to monitor endothelial cell lining for sites of infection and to attack and to sequester pathogens. This may result in an infection (FIG. 6).
[0021] The object of the present invention is to provide a novel and previously unknown method for augmentation of the immune system in mammalian and avian species. The invention may be applied to, but not limited to, mammalian and avian species and will reduce susceptibility of an individual to both fungal and bacterial diseases.
[0022] A further object of this invention is to provide a method for augmentation of immune function and to thereby minimize or obviate morbidities and mortalities caused by, but not limited to, pathogenic fungi and bacteria with a preparation comprising a combination of β-1,3 (4)-endoglucanohydrolase, β-glucan, diatomaceous earth, glucomannan, and mineral clay, such as aluminum silicate, montmorillonite clay, bentonite or zeolite.
[0023] Another object of the invention is to provide a composition comprising a combination of β-1,3 (4)-endoglucanohydrolase, β-glucan, diatomaceous earth, mineral clay, and glucomannan, which additively augments immune function and thereby, reduces potential of pathogenic fungi and bacteria to cause morbidities and mortalities in mammalian and avian species.
[0024] Additional objects, advantages and novel features of the invention will be set forth, in part, in the description that follows and will, in part, become apparent to those skilled in the art upon examination of the following or may be learned with the practice of the invention. To achieve the foregoing and other objects, and in accordance with the purposes of the present invention as described herein, a novel method is described for the augmentation of immune function of mammalian and avian species. In particular, this invention increases expression of neutrophil L-selectin and interleukin-1β and thereby minimizes or eliminates the colonization of the epithelial surfaces and underlying parenchymal tissues by pathogenic fungi and bacteria, reduces the populations of pathogenic organisms in blood and thereby minimizes or eliminates pathologies directly caused by and indirectly caused by this colonization. The invention comprises a mixture of β-1,3 (4)-endoglucanohydrolase, β-glucan, diatomaceous earth, mineral clay, and glucomannan. The diatomaceous earth is standard commercial grade available from a variety of sources. The β-1,3 (4)-endoglucanohydrolase is produced from submerged fermentation of a strain of Trichoderma longibrachiatum. The β-1,3 (4)-glucan and glucomannan are derived from a commercial product and are an extraction from any of a number of yeast organisms. The mineral clay product is a standard commercial grade (examples include, but are not limited to, montmorillonite clay, bentonite and zeolite). Extractions and productions of diatomaceous earth, yeast cell wall extract and mineral clay are well known in the art and commercially-available.
[0025] The compositions which are provided by the invention can be fed to any mammalian or avian species including, but not limited to, bovine, equine, ovine, caprine and avian species. When admixed with the feed or food or fed as a supplement, the invention augments immune function thereby reducing colonization by pathogens. The invention also minimizes or eliminates invasion of the blood compartment by pathogenic fungi and bacteria. The invention thereby minimizes or eliminates the manifestations of the pathologies typically associated with epithelial and systemic fungal and bacterial infections. Administration of the product may be used as a prophylactic (i.e., to prevent colonization and growth of pathogenic fungal and bacterial species in mammalian or avian species), as an additive to feeds or foods infected with pathogenic fungi or bacteria or as a preferred method to treat and thereby minimize or eliminate an existing, diagnosed or non-diagnosed, fungal or bacterial infection. Application of the invention as described herein and via the specific and novel mechanisms described herein will minimize and possibly eliminate manifestations of fungal and bacterial infections. Application of the invention as described herein will also minimize or possibly eliminate manifestations associated with the presence of pathogenic fungal and bacterial organisms, as identified above, in food or feed of mammalian and avian species.
[0026] The accompanying drawings and photographs which are incorporated into the following "Detailed Description of the Invention" form part of the specification and illustrate several aspects of the present invention and, together with the Detailed Description, serve to explain the details of the invention.
[0027] FIG. 1 is a schematic drawing illustrating the movement of neutrophils through a blood vessel. L-selectin (CD62L) is shown as circles on the surface of the neutrophils A-E. These allow docking of the neutrophils with endothelium. There is shedding of L-selectin and migration of neutrophil into peripheral tissue toward a site of infection F. (Source: Burton and Erskine, 2003.)
[0028] FIG. 2 is a schematic diagram illustrating toll-like receptors (TLRs) on the surface of an immune cell, and signal transduction following binding of TLRs with microbial PAMPs (pathogen-associated molecular patterns). (Source: M. Adib-Conquy, C. Fitting, 2002.)
[0029] FIG. 3 illustrates a macrophage cell engulfing a bacterium in a process called phagocytosis. Toll-like and other receptor direct phagocytes to recognize microbes. Pseudopodial projections surround the bacterium. (Source: Travis, 2002.)
[0030] FIG. 4 is a bar graph of cortisol levels in dairy cattle relative to day of parturition. Cortisol peaks at day of parturition. (Source: Weber et al., 2001.)
[0031] FIG. 5 is a bar graph of neutrophil surface CD62L (L-selectin) expression in cattle relative to day of parturition. (Source: Weber et al., 2001.)
[0032] FIG. 6 is a schematic diagram illustrating neutrophils lacking L-selectin expression in a stressed dairy cow. (Source: Burton and Erskine, 2003.
[0033] FIG. 7. Effect of five experimental treatments on concentrations of neutrophil L-selectin. An experiment was conducted with 60 sheep. Twelve sheep were allocated to each treatment. The treatments consisted of:
[0034] 1. Control
[0035] 2. Immunosuppressed (daily injections of Azium [Dexamethasone], 0.1 mg/kg twice/day).
[0036] 3. Immunosuppressed plus experimental product fed at 0.5% of daily dry matter intake.
[0037] 4. Immunosuppressed plus moldy feed (addition of Aspergillus fumigatus-infected wheat mill run; 1.5 lbs/head/day).
[0038] 5. Immunosuppressed plus moldy feed (as in Treatment 4) plus the experimental feed product as outlined in Treatment 3.
[0039] The duration of the trial was 28-days. On Day 28, blood was taken from six sheep per treatment and neutrophils were recovered by Percoll gradient centrifugation. The concentrations of L-selectin were determined by Western blot analysis using an antibody specific to L-selectin. Relative concentrations of L-selectin among the five treatment groups are shown in FIG. 8.
[0040] FIG. 8. Scanning densitometry of data shown in FIG. 7.
[0041] FIG. 9. Analysis of neutrophil interleukin-1β in the same sheep neutrophil samples presented in FIG. 7.
[0042] FIG. 10. Scanning densitometry of data shown in FIG. 9.
[0043] FIG. 11. Concentrations of Aspergillus fumigatus in blood samples taken from sheep on Day 28 of the above study. A. fumigatus DNA levels were assessed using a quantitative Sybr-Green PCR-based assay specific for A. fumigatus.
[0044] The present invention is based on the novel discovery that a combination of β-1,3 (4)-endoglucanohydrolase, β-1,3 (4)-glucan, diatomaceous earth, mineral clay, and glucomannan effectively augments immune function and reduces colonization of tissues and blood by a pathogen.
[0045] The β-1,3 (4)-endoglucanohydrolase is from a commercial source and is produced from submerged fermentation of a strain of Trichoderma longibrachiatum.
[0046] The diatomaceous earth is prepared by methods commonly known in the art. It is available as a commercially-available acid-washed, product with 95% silica (SiO2) and with its remaining components not assayed but consisting primarily of ash (minerals) as defined by the Association of Analytical Chemists (AOAC, 2002).
[0047] The yeast cell wall extract is prepared by a method commonly known in the art. It is a commercial source of β-1,3 (4) glucan and glucomannan derived from primary inactivated yeast (Saccharomyces cerevisiae) with the following chemical composition:
[0048] Moisture 2-3%
[0049] Dry matter 97-98%
[0050] Proteins 14-17%
[0051] Fats 20-22%
[0052] Phosphorus 1-2%
[0053] Mannans 22-24%
[0054] β-(4) glucan 24-26%
[0055] Ash 3-5%
[0056] The mineral clays (aluminosilicates) used in this invention may be fulfilled by any of a variety of commercially-available clays including, but not limited to, montmorillonite clay, bentonite and zeolite.
[0057] In a preferred embodiment of the invention, β-1,3 (4)-endoglucanohydrolase, diatomaceous earth, yeast cell wall extract and mineral clay are combined at 0.05-3%, 1-40%, 1-20% and 40-92%, respectively. In a preferred composition, β-1,3 (4)-endoglucanohydrolase, diatomaceous earth, yeast cell wall extract and mineral clay are combined at 0.1-3%, 5-40%, 2-10% and 40-80%, respectively. In an especially preferred embodiment of the invention, β-1,3 (4)-endoglucanohydrolase, diatomaceous earth, yeast cell wall extract and mineral clay are combined at 0.2-3%, 30-40%, 4-6% and 50-65%, respectively. The preferred physical form of the invention is a dry, free-flowing powder which is suitable for direct inclusion into a feed, food product or as a supplement to a total mixed ration or diet.
[0058] The compositions provided by the present invention may be incorporated directly into commercially-available feeds or food products or fed as supplements to commercially-available feeds or food products. The composition contained in the present invention may be fed to any mammalian or avian species. The methods of the invention comprise augmenting immune function in mammalian and avian species. When incorporated directly into feeds, the present invention may be added to feeds in amounts ranging from 0.1 to 5 kg per ton of feed. In an especially preferred composition, the invention may be added to feeds in amounts ranging from 1-2 kg per ton of feed.
[0059] The composition contained in the present invention may be added to animal feedstuffs or to foods in amounts ranging from 0.0125% to 2% by weight of feed. In a preferred embodiment, the composition is added to animal feedstuffs or to food in amounts from 0.0625% to 1% by weight of feed. In an especially preferred embodiment, the invention is added in amounts from 0.125% to 0.5% by weight of feed.
[0060] Alternatively, the composition contained in the present invention may be fed directly to mammalian or avian species as a supplement in amounts 0.016 grams/kg to 0.37 grams/kg of live body weight per day. In an especially preferred embodiment, the invention may be provided to mammalian and avian species in amounts of 0.10 grams/kg to 0.20 grams/kg of body weight per day. One of skill in the art can appreciate that the amount of the invention fed can vary depending upon the animal species, size of the animal and type of the feedstuff to which the invention is added.
[0061] The novel methods of this invention comprise the ability of a combination of β-1,3 (4)-endoglucanohydrolase, diatomaceous earth, yeast cell wall extract and clay to augment immune function. The benefits resulting from the application of the invention to mammalian species include, but are not limited to, reduced death losses, reduced incidence of mycotic abortion, reduced incidence of jejunal hemorrhage syndrome (dead gut syndrome), reduced incidence of scouring (diarrhea), improved growth rate, improved efficiency of growth, improved milk production, improved efficiency of milk production and reduced somatic cell counts in milk products (dairy animals). The benefits from the application of the invention to avian species include, but are not limited to, reduced death losses, improved growth and egg production, improved fertility, and reduced incidence of enteric diseases.
[0062] The following are intended to be illustrative of the invention, and are not to be considered restrictive of the scope of the invention as otherwise described herein.
[0063] An experiment was conducted using 60 growing male and female sheep. Sheep were allocated to one of the five treatments (seven females and five males per treatment):
[0064] 1. Control.
[0065] 2. Immunosuppressed (daily injections of Azium [Dexamethasone], 0.1 mg/kg twice/day).
[0066] 3. Immunosuppressed plus the invention fed at 0.5% of daily dry matter intake.
[0067] 4. Immunosuppressed plus moldy feed (addition of Aspergillus fumigatus-infected wheat mill run; 1.5 lbs/head/day).
[0068] 5. Immunosuppressed plus moldy feed (as in Treatment 4) plus the invention as outlined in Treatment 3.
[0069] Animals were fed a dairy-type diet for a period of 28 days. Immunosuppression was mediated in Treatments 2, 3, 4 and 5 by daily injection of Azium using a high dose (a model of extreme stress: Weber et al., 2001). Sheep on Treatments 4 and 5 were challenged with a pathogenic mold by feeding wheat mill run which had been contaminated with a pathogenic mold (Aspergillus fumigatus). Sheep on Treatments 3 and 5 were supplemented with the invention at a rate of 0.5% of their daily dry matter intake. Following 28 days, blood samples were taken via jugular puncture and the neutrophil fractions were isolated using Percoll density gradient centrifugation. Following this, samples of neutrophil protein were processed using sodium dodecyl sulfate polyacrylamide gel electrophoresis and Western blotting using antibodies which are specific for L-selectin and interleukin-1-β. Relative concentrations of L-selectin and interleukin-1-β. were assessed using scanning densitometry.
[0070] FIGS. 7 and 8 demonstrate effects of the five experimental treatments on neutrophil L-selectin. Injection with Azium caused a marked reduction (P<0.05) in L-selectin and provides evidence that Azium injection was, in fact, immunosuppressive. Addition of mold to the diets had no effect (P>0.05) on L-selectin concentrations. Of interest, addition of the invention to feed (Treatments 3 and 5) caused restoration (augmentation: P<0.05) of L-selectin.
[0071] Interpretation: The novel invention successfully restored (augmented) normal levels neutrophil L-selectin. Restoration of L-selectin on neutrophil surfaces will re-establish their ability to monitor the endothelial lining for pathogens.
[0072] FIGS. 9 and 10 demonstrate effects of the five experimental treatments on neutrophil interleukin-1-β concentrations. Azium treatment caused a marked reduction (P<0.05) in neutrophil interleukin-1-β concentration. This demonstrates that Azium was immunosuppressive. The novel invention had no effect (P>0.05) on neutrophil interleukin-1-β in the absence of a pathogen challenge (i.e., Treatment 3 versus Treatment 2); however, the invention caused a marked increase (P<0.05) in neutrophil interleukin-1-β in the presence of a pathogen challenge (i.e., Treatment 5 versus Treatment 4).
[0073] Interpretation. Interleukin-1β is an important pro-inflammatory cytokine which enables the neutrophil to fulfill its role as a phagocyte. Ability of the feed product to restore interleukin-1β in the presence of a pathogen (A. fumigatus) demonstrates that pathogens potential effects of the invention on immune function.
[0074] FIG. 11 shows the effects of the five experimental treatments on blood concentrations of A. fumigatus. A. fumigatus concentrations were determined using a Sybr-Green real-time quantitative polymerase chain reaction (PCR) assay developed in our laboratory. The results demonstrate that the invention reduced (P<0.05) A. fumigatus concentration in blood.
[0075] Interpretation. The restoration of neutrophil function shown in FIGS. 7-10 manifests itself by reducing pathogen load detected within the blood compartment. The invention reduces pathogen load.
[0076] These results show that the composition of the invention (i.e., mineral clay, yeast cell wall extract, diatomaceous earth and β-1,3 (4)-endoglucanohydrolase) is capable of a previously-undescribed effect of augmenting immune function. The invention specifically restores levels of L-selectin and interleukin-1-β in neutrophils thereby restoring the ability of neutrophils to monitor for the presence of invading pathogens.
[0077] The combination of products augments immunity in mammalian and domestic species and thereby prevents the invasion and colonization of the blood compartment. It represents a mixture which is flowable and easily incorporated into feed products and food products. The present invention was effective in achieving its immunostimulatory effects under growth conditions which might be found in mammalian and avian digestive systems where nutrients, moisture, oxygen and elevated temperatures are provided by the host.
[0078] The foregoing description of the preferred embodiment of the invention has been presented for purposes of illustration and description. It is not intended to be exhaustive or to limit the invention to the precise form disclosed. Obvious modifications or variations are possible in light of the above illustrations. The embodiment was chosen and described to provide the best illustration of the principles of the invention and its practical application to thereby enable one of ordinary skill in the art to utilize the invention in various embodiments and with modifications as are suited to the particular use contemplated. All such modifications and variations are within the scope of the invention as determined by the appended claims when interpreted in accordance with the breadth to which they are fairly, legally and equitably entitled.
Patent applications by Neil E. Forsberg, Corvallis, OR US
Patent applications by Steven B. Puntenney, Ione, OR US
Patent applications by OmniGen Research, L.L.C.
Patent applications in class Acting on glycosyl compound (3.2) (e.g., glycosidases lysozyme, nucleosidases, cellulase, etc.)
Patent applications in all subclasses Acting on glycosyl compound (3.2) (e.g., glycosidases lysozyme, nucleosidases, cellulase, etc.)
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Signs That You Need Dental Implants
A person who has lost one or several teeth is a strong candidate for implant dentistry. Dental implants can offer a permanent solution to tooth decay and missing teeth. They can also provide structural support for the entire mouth.
Dental implants usually last longer than other restorative dental procedures and give your teeth a more natural appearance. They look, feel, and function just like your natural teeth.
If you are tired of dealing with denture adhesives or suffering from pain caused by broken or severely cracked teeth, dental implants may be the right treatment for you. But how will you know if you require dental implants? There are some obvious signs to look out for.


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Kaspersky Anti-Virus 5.0 for Windows Workstations
IztokK, in Protection for Business
IztokK, in Protection for Business
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The Relative Age Effect among Elite American Youth Soccer Players
Glamser, Francis D., Vincent, John, Journal of Sport Behavior
Children are frequently grouped by age for school or sport activities in order to control for the effects of intellectual and physical development. However, even when groupings are limited to 1 -year categories, developmental differences can be great (DeMeis & Stearns, 1992). In such cases, some children will be almost a year older than other children. The outcome of this advantage has been termed the relative age effect (RAE) or the birth date effect.
Youth sport programs use cutoff dates to ensure that children will receive age appropriate instruction and to allow for fair competition. However, a large body of research has made it clear that the age differences within a year can have extremely large effects on sports success, especially at elite levels. The discovery of the RAE in children's sports came as the result of an analysis of the birthdays of professional ice hockey players in Canada. Barnsley, Thompson, and Barnsley (1985) found that these players were much more likely to have been born early in the calendar year than in later months. First quarter birthdays were twice as common as last quarter birthdays.
In a follow-up study it was found that the RAE was even greater among elite youth teams (Barnsley & Thompson, 1988). In the case of 9- and 10-year--olds, almost 70% of the top players were born in the first half of the year. More striking was the fact that only 10% had birthdays in the last quarter of the year. Interestingly, the RAE was not evident in professional ice hockey in the 1960s (Daniel & Janssen, 1987). This might suggest that the regimentation and sophistication of youth hockey in recent decades may be a factor in producing the RAE.
Once the RAE in sports was discovered, numerous researchers investigated the effect in various sports around the world. An excellent review of that body of research may be found in the work of Musch and Grondin (2001). Their review presents evidence of a strong RAE in soccer, ice hockey, swimming, and tennis.
The evidence for a strong RAE in international and professional soccer is overwhelming (Musch & Grondin, 2001). Professional players in the United Kingdom, Belgium, Australia, Brazil, France, Netherlands, Germany, and Japan are more likely to have a birthday in the first half of the soccer year than in the second half. The percent of players with birthdays in the first half of the soccer year is near 60 in most studies.
The data for elite youth players in Europe reveal an even stronger RAE (Musch & Grondin, 2001). Studies of players in the United Kingdom, Sweden, and Belgium found approximately 70% of elite youth players had birthdays in the first half of the soccer year. A literature review of the various factors relevant to the early identification of soccer talent by Williams and Reilly (2000) makes it very clear that advanced physical maturation and stature are extremely important in the selection of elite youth soccer players. Children born early in the selection year are greatly advantaged. These authors also note a "residual bias" that accrues from being selected very early in this process. The theoretical underpinnings of the RAE may be found in the concepts of developmental advantage, socialization, and self-fulfilling prophecy. In the initial stages of the selection of young athletes, a 6 to 12 month developmental advantage can be decisive. Slightly older participants tend to possess physical and psychological advantages that make their selection more likely. Once young players are selected for elite sport participation, they are taught the correct skills and techniques, while being socialized into appropriate attitudes for later success by capable coaches. This specialized socialization process is not experienced by players not selected for elite teams. The absence of this early experience puts younger players who were not initially selected at risk of non-selection at subsequent player evaluations. …


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May 9, 2019
Animal, vegetable, or mineral? In its all-out competition with Amazon—as well as every other online and brick-and-mortar low-cost retailer—Walmart is offering more to those who shop in most consumer categories, including pet products.
On May 7, WalmartPetRx.com announced that it is offering economical pet prescriptions "for dogs, cats, horses, and livestock from over 300 trusted brands to treat conditions like flea and tick, heartworm, allergy, arthritis, and more."
Customers now can purchase prescription pet medications at the stores or online, and have them delivered right to their (doggie) doors.
"By working directly with veterinarians to receive and fill prescriptions, we're able to save busy pet parents time, which could mean another walk around the block for Cooper," said Kieran Shanahan, SVP of Retail–Food, Consumables, Health & Wellness, Walmart U.S. eCommerce, in a company press release.
He noted, "For those who prefer to fill their pet prescriptions in Walmart stores, later this month we'll stock our 4,500+ pharmacies with the top-30 most-requested pet meds, which means getting your pet's prescription same-day."
What's more, the discount chain said it is stocking a more wholesome assortment of pet foods and expanding its in-store veterinary clinics. Indeed, the discount chain has expanded its pet assortment online with more than 100 new brands over the past year, including Blue Buffalo, Greenies, and Hill's Science Diet. It also is marketing premium and "free-from" options for its private-label brands, Pure Balance, Golden Rewards, and Vibrant Life, at three-fourths the price.
And, with 68% of US households owning a pet and 90% of Americans living within 10 miles of a Walmart store, the chain is expanding its in-store retail veterinary clinics, starting with nine new clinics in the Dallas-Fort Worth area in late May and June.
"With plans to reach 100 veterinary clinics over the next 12 months, these clinics offer affordable, high quality and convenient services to save customers as much as 40% to 60% on vaccines and minor illness packages and exams," Shanahan said.
Research contact: @Walmart


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World Points of Interest Data
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Apollo Disposable Electronic Cigarette Review
Apollo Disposable Electronic Cigarette
The Apollo disposable electronic cigarette is not something I use on a regular basis as I have a fair amount of vaping kit that fulfils my personal needs (see other reviews). However, I've been meaning to review one for a while but never got around to it. So today, I'll explain what these are all about.
If you are new to the world of electronic cigarettes and the vaping scene in general lets get down to basics. Most ecig users start out on something fairly basic. I know I did. 5 years ago, ecigs were extremely primitive and most, if not all, replicated a real cigarette in looks if not performance. Over the years, and thanks to the personal innovation of a number of ecig users, various "mods" started to appear. Chinese manufacturers quickly picked up on these and started mass producing more durable and longer lasting products.
You see the problem with the earliest ecigs was size. After all, these things were nigh on identical to a cigarette dimensionally, thus battery capacity and ultimately life was limited to say the least – a typical battery lasting anywhere between 30 mins to 2 hours (the latter, if lucky). In addition, they didn't hold a decent charge after a few months, so a hefty battery arsenal was always needed.


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Breast Augmentation: 350CC Implants, $5000 in Vancouver, BC.
Procedure rating
Breast augmentation - Silicone breast implants
Performed 2016
Procedure review
Ever since I was in high school, I knew I wanted to have a breast augmentation. It was hard for me to watch all my friends develop as I waited for my own breasts to develop. Years went by, and I was still waiting for that moment, but it never happened. I am confident in my body, but my breasts made me feel incomplete. As I got older, I had a few friends that had breast augmentations and I asked them of their experiences and how they felt afterwards. They told me that it was the best decisions of their lives, as they shared similar stories as me. At first I had done my research and I had planned to get my breasts done in Miami, but after my friend referred me to Dr. Benjamin Gelfant in Vancouver, BC I was sold. I called to schedule a consultation to see what size implants would be best for me. In my head, I had originally wanted 385 CC, but after the consultation I realized that 350CC was a better choice for my body size. The receptionist at Dr. Gelfant was incredibly sweet and Dr. Gelfant was nothing but professional and knowledge. I booked my surgery date immediately after my consultation, and put down $5000 deposit. My surgery date was booked for a month after my consultation. I was beyond excited and I could not believe that it was happening. Time seemed to fly by as my surgery date came upon me.
The day before my surgery, I paid the remaining balance of the surgery was over in 1 hour and I stayed at the hospital for 2 hours for them to monitor me. When I woke up from the anesthesia, my throat was sore and dry but I did not feel anything around my chest area. But as they wheeled me out to the resting area, I felt a tightness around my chest and very cold, but no sharp pains. I was so cold, I had to have a heat blanket on me as I waited to go home. The nursing staff offered me crackers and water but I couldn't swallow as my throat was so dry. After two hours, they discharged me from the hospital and the ride home was bearable as I still felt no immediate pain except for the slight tightness in my chest. As I could not get up by myself, I had prepared a little set up on my couch where I was slightly inclined so to get up easier. I was given two weeks of pain medication, but I ended up only taking 3 day's worth. I was told not to do any heavy-lifting or any strenuous activities. I had booked off 5 days off work to give myself time to recover, although by the third day I was able to walk around on my own. I am a very active person, but I had to take at least a month off from the gym as I could not lift weights. When a week passed after my surgery, I felt fine but still some tightness in my chest. It's been a year now, and the implants have softened and they feel as if they belong to me now. I don't have any more tightness in my chest, except for when I am doing push-ups I can feel a slight pull. I am incredibly happy that I went ahead with this procedure and I have no regrets at all. I feel happy with my body now as it is and I highly recommend anyone who is considering breast augmentation to find a doctor that they feel comfortable with and make sure to do your research thoroughly before going for a consultation as it may be quite overwhelming.


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Cane type begonias are easy to root, and now is a good time to take these cutting and root outdoors in a cool shady place. Often times too, they can be rooted in water. I hope this blog will explain an easy way to root these cuttings outdoors. First, I use tips of the stems to root. While they can be snipped off, I like to break them off for rooting. Once they are cut or broken off, I stick the cut ends in a rooting stimulator and tap off the excess powder. Once this is done I usually cut the leaves in half and stick the cuttings in a good porous soil that is well drained and water well. The container of cuttings is placed in a cool shady location outside. I water the cuttings daily, and in three to four weeks roots should appear. Once they have rooted I leave them a while longer to make sure they have a good root structure. Once rooted, I gently lift then out of the rooting medium and pot them up and allow them to grow into new small plants. This is a great way to over winter plants that are simply too big to move inside, or take a cutting of a friend's begonia to get one going for yourself.
August 21, 20170Next Post


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With only a few months left in 2011, it is time to look at IRA contributions.
"This is one of the best times to start looking at your 2011 IRA contributions and one of the smartest things you can do is add mutual funds to the account," said Evan Tunis, president and CEO of Next Exit Retirement. "If you don't know what type of funds will work to your advantage, then just call me, and we can discuss what would work the best."
The beauty of IRAs is that they have many advantages that will make a smart investor quite pleased with the prospects for their future. The IRA can help manage retirement plans with flexibility and allows funds to be used in the IRA to be invested in non-traditional investments. "And that means, you could choose to invest in businesses, tax liens, real estate or even loans," added Tunis.
The bottom line is that IRAs are very good alternatives for those who wish to diversify their investment portfolio, and all of the investments can be done within the same account envelope or structure. "That means it is a very handy tool for investors wanting to look to their future retirement and who want to grow their wealth to be ready to retire," Tunis remarked.
"LLCs are often used in situations like this," indicated Tunis, "as LLC programs let people secure their investments. That means that IRAs, which are time sensitive, tend to be good choices for those wanting a safer investment option with total control over the investments and the retirement funds."
IRAs are a great way to save for the future. "If this appeals to you, call me and we can review your options. The advice is free and the expertise and customer service you get is superior. This is my job and I work to ensure your money works for your retirement," Tunis stated.


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What are you doing to Be in SHAPE?
So often, women are busy caring for everyone: children, husband, parents, and co-workers among others that they forget to take care of themselves. They often develop that superwomen complex. "A woman with a Superwoman Complex constantly needs to prove that she is smart, secure, strong and self-sufficient as defined by Urban Dictionary." As we approach the holiday season, it is time that you slow down and change things in your life.


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The Wonderful Benefits of an Iontophoresis Machine
You may have heard about excessive sweating and how people have such a big problem with this; if you want to find a cure, you have come to the right place. There are many solution that you can try in order to fight your excessive sweating problems so stick with us to find out one way that you can deal with it. If you think that it is bad to sweat and that if you sweat, this is not a good thing for you because you are going to get wet and sticky, you are mistaken. You actually have to sweat sometimes in order to get out the oils in your body. Iontophoresis machines can help those people who sweat really excessively so if you are someone who really sweats a lot, you should really get this wonderful product because it will really not let you down as we shall soon see.
One really good thing about using an iontophoresis machine is that it tightens and makes the tissue of your body more firm. Having tighter skin will not allow the sweat in your body to pour out in abundances so this is really good for you if you really hate it when you sweat a lot. This product is really convenient because it is really small and you can use it wherever you go so that you will not always be pouring and dripping in sweat. This is a really wonderful way how you can stop your problem of sweating too much so you should really get this wonderful product if you really need help with your sweating issues. If you really want this product, you can find it online or you can go to a mall and look for these wonderful products there. We hope that you get your very own machine today.
The next wonderful thing that you can get from using an iontophoresis machine is that it can make your skin smoother and also calmer. There are many people who do not really have wonderful skin and if you are also someone who does not have good skin, you should really try using this wonderful product because it can really help you. You may not want to try this product because you are afraid of it but if you read about the reviews on this wonderful product, you may be convinced that it really does work. You may really want to have skin that is smooth and moist because you find that your skin is too dry and too ugly. There are more benefits that you can get from this wonderful machine and if you would like to know more, you should just do more research on this product and you will get to know what else this iontophoresis machine an give to you.
Looking On The Bright Side of Systems


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|George Stevens Academy
|Ellsworth High School
At Ellsworth, Katey Curtis scored two goals to power Ellsworth past George Stevens Academy.
Morgan Card and Emma Sweeney tacked on a goal each, and Anika Firestone and Brianna Reardon picked up assists for Ellsworth.
Goalie Jessica Toothaker made three saves for Ellsworth, and GSA 'keeper Mallory Flannery made nine saves.


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Please note these upcoming dates for Belfast Royal Academy:
Friday 7th April
The Colours Ceremonies will take place during the course of the morning and the Spring Term will end at 12 noon. There will be buses to Yorkgate, but no special buses. The Canteen will be open for break, but not lunch. (The Form II Parent-Teacher Consultation will take place during the afternoon.)
Monday 10th April – Friday 21st April
School will be closed for the Easter holidays.
Monday 24th April
Staff Day. Pupils should not attend, with the exception of:
- Form MVI who should attend School (9.00a.m. – 3.10p.m.) for the first day of their mock examinations.
- Form LVI who should attend School (9.00a.m. – 3.10p.m.) for additional teaching.
Uniforms should be worn. There will be Yorkgate buses, but no special buses and the school cafeteria will not be open. Form LVI pupils should bring a packed lunch.
Tuesday 25th April
The Summer Term will begin for all pupils at 8.40 a.m. This will be the second day of mock examinations for pupils in Form MVI.
Monday 1st May
Staff Day. Pupils should not attend.


text: Dear NACLA friends, Last weekend, Bolivian federal police brutally repressed lowland indigenous marchers protesting the TIPNIS highway. The move sparked widespread public outrage, and led to the resignation of several Bolivian officials. NACLA blogger Emily Achtenberg has been covering the TIPNIS conflict extensively since early August. Don't miss the latest developments at her blog, Rebel Currents. Online this week: Todd Miller: Of Landlords and Counterinsurgency Fred Rosen: Paramilitary Justice Nazih Richani: Latest UNDP Report on Colombia: 'It's the Rural Economy, Stupid.' Currently in print: "Cuba: Salvaging a Revolution?" Cuban sociologist Mayra Espina Prieto examines the implications that Cuba's new economy will have for social policy. Anthropologist Katrin Hansing discusses how the legacy of the Special Period in Cuba has not only changed many Cubans' attitudes toward their lives but also opened up new cultural spaces for expression. Marguerite Rose Jiménez describes one leading light of the Cuban economy, its innovative biotechnology sector, focused on producing low-cost medicines. Historian Alejandro de la Fuente offers an assessment of persistent racial inequality in Cuba. Anthropologist Noelle Stout discusses the rise of gay tolerance on the island. Noted international relations scholar William M. LeoGrande reviews U.S.-Cuban relations under the Obama administration as a case of missed opportunities for improvement. Upcoming NACLA Events: NACLA will cosponsor "Impugning Impunity: A human Rights Documentary Film Series" from November 3-5 at the Museum of the City of New York. The festival will kick off with Hollman Morris' "Impunity" on November 3rd at 6 pm, followed by a Q&A with the Colombian journalist. Other films featured are: "Prosecutor," "The Mexican Suitcase," "Granito," and "Nostalgia of Light." Subscribers can read a review of "Nostalgia of Light" in our archive. Stay tuned for upcoming interviews, event announcements, and a preview of our Human Rights issue. Your subscription is vital to our work. Support NACLA today by subscribing to the award-winning NACLA Report. NACLA Needs Your Support! Visit the NACLA Store to purchase back issues of the Report, books, and more. To unsubscribe please reply to this e-mail with "unsubscribe" in the subject line. CONTACT US: NACLA | 38 GREENE ST. 4TH FL., NEW YORK NY 10013 | TEL: (646) 613-1440 | FAX (646) 613-1443 | firstname.lastname@example.com Donate to Support the North American Congress on Latin America


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Tax Refund Fraud: Are Your Employees Protected?
In 2013, the IRS named tax refund identity theft its number one scam of the year. Between 2008 and 2012, the Department of Justice identified over a half million people whose identities had been stolen as part of tax refund identity fraud. The U.S. General Accountability Office (GAO) issued a report earlier this year estimating the cost of fraudulent tax returns to taxpayers was as much as $5.2 billion in 2013. While the IRS has improved fraud screening filters and continues to make identifying and prosecuting these crimes a priority, tax refund identity theft is expected to be an ongoing issue in the years ahead. Here's a closer look at what you should know.
How Does Tax Refund Fraud Work?
Tax refund fraud is relatively simple to execute. Criminals obtain the names, birth dates, and social security numbers of unsuspecting individuals. Names are sometimes bought in lists or procured through bribing employees of businesses with access to this information, like banks or hospitals. The criminal then uses an online tax preparation site to electronically file a false tax return. (E-filed tax returns don't require supporting documentation.) They may then elect for their refund to be disbursed onto a prepaid debit card, which can be hard to trace.
Many victims of this crime are unaware of the problem until they are notified by the IRS of a discrepancy. Commonly, individuals will receive notification that they've filed multiple tax returns, received wages from an employer unknown to them, or that they have a balance due for a year when they didn't file a tax return.
The IRS uses a "look-back" compliance method, rather than waiting until all checks are complete before issuing refunds. Form W-2 information is often unavailable until long after employee returns are filed. As a result, issues aren't caught until months after the fraud has occurred.
GAO recommendations include encouraging businesses to e-file Forms W-2 and accelerating W-2 deadlines. But whether the government will take action on these recommendations has yet to be seen.
How Can Businesses Help Protect Employees?
Businesses can take several steps to help protect employee information and assist employees who may be victims.
- Use an online payroll provider. Employers collect sensitive information from employees, including birth dates and social security numbers, for tax reporting purposes. Paper files or desktop-based systems potentially make data vulnerable to hackers or dishonest employees. Using an online payroll provider can increase the likelihood that records are stored securely, that security protocols are being followed, and that internal access to information is restricted.
- E-file Forms W-2. If the option is available to your business, consider e-filing your Forms W-2 and 1099. Taking this step gives the IRS access to comparative information, and enables them to assess the accuracy of returns filed with your employees' social security numbers, more quickly.
- Consider offering identity protection benefits. Another strategy to help protect your employees from identity theft is offering identity protection benefits. Options to consider include credit monitoring and active support resolving identity theft cases.
- Educate your employees. Many people have never heard of tax refund identity fraud. While media reports and government outreach help raise awareness, employers can advise employees on what tax refund fraud is and how to prevent it. For more information, refer employees to the IRS' identity protection resources page.
Companies can help combat tax refund identity theft by using online payroll systems to protect valuable employee data and by educating employees on resources available from the IRS.


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Karen Clancy, a blues singer/songwriter from Florida, has released her first LP, self-titled. "The album, Karen Clancy, is a culmination of a life that has always had a soundtrack," says Clancy.
The record showcases her adroit, tender handling of traditional blues tenets while remaining a modern interpretation of classic, deep-south undertones. The album is markedly comprehensive, boasting rich components of jazz, classical, and Irish folk music, and marks the beginning of her available catalog.
Her collaboration with Mark Hodgson inspired the inclusion of several blues classics, such as Bessie Smith's "Baby, Won't You Please Come Home," Rosa Henderson's "Don't Advertise Your Man," and the standard, "Nobody Knows You When You're Down and Out."
Geoff Weeks accompanies on the piano, of which performance Clancy has said, "His talent must be mentioned fervently…these songs came to life in his hands."
"Back in the Day" is Clancy's memoir of growing up on the beachside of New Smyrna: "Back in the day I used to sneak, underage, into the local clubs to hear Southwire, a band in which Billy Chapin played guitar. Who would've thought all these years later I would be recording my first album in his studio?"
Of the Gaelic influence on her work Clancy writes, "As the youngest of ten Clancy siblings it is difficult to ignore the Irish influence written into my DNA. 'She Moved Through The Fair' is a nod to that history while breaking with tradition using the Universal Energy of the Sitar as an accompaniment, played beautifully by Rick deYampert."
Clancy's influences include Bessie Smith, Muddy Waters, Junior Wells, Ethel Waters, Stephane Grapelli, and Big Mama Thornton.
She has performed at myriad locales, including New Smyrna Beach, Miami, Key West, Tampa, New Orleans, Houston, Colorado, Chicago, D.C., Vermont, Hana, Madrid, Bruges, Paris, and Venice.
The LP "Karen Clancy" is available for purchase and download from iTunes, or at her website, http://www.karenclancy.net.
Hear her first at http://www.reverbnation.com/#!/karenclancy
Karen Clancy
4615 Doris Drive
New Smyrna Beach, Florida 32169


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A Funny Economist?... I've Never Heard of Such A Thing
Peter Ricchiuti (Ri-Shooty) is the business school professor you wish you had back in college! He teaches courses on
the financial markets at Tulane University's Freeman School of Business. His insight and humor have twice made
him the school's top professor.
Peter started his career with the investment firm of Kidder Peabody and later managed over three billion dollars as
the assistant treasurer for the state of Louisiana. In 1993 he founded Tulane's highly acclaimed BURKENROAD
REPORTS stock research program.
He has been featured onCNN andCNBCas well as in The New York Times, BARRON'S, The Washington Post and The
Wall Street Journal. Over the past twenty years Peter has addressed hundreds of groups in 47 states and several
countries. He has presented to a wide variety of audiences including workshops for the New Orleans Saints.


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What We Want
Since we are a rotating editorial board of approximately ten members, we annually discuss what we are looking for in… Read more What We Want
Do You Use Submittable? Are You a Publisher? An Editor?
We are in the throes of setting up our Submittable presence for collecting submissions for our annual community college literary… Read more Do You Use Submittable? Are You a Publisher? An Editor?
Looking for Copies?
You can find the 2017 Cosumnes River Journal at: Avid Reader, 1945 Broadway, Sacramento Beers Book Center, 915 S Street,… Read more Looking for Copies?
CRC Connection
http://www.thecrcconnection.com/news/2017/05/15/english-department-holds-11th-annual-cosumnes-river-journal-release The English department held its 11th-annual Cosumnes River Journal Release on May 4. Heather Hutcheson, an English professor at… Read more CRC Connection
Call for Submissions
English Department_JOURNAL_Flyer_2017_HQ
Cosumnes River Journal 2017 Celebration
On Thursday, May 4, the English department proudly celebrated the release of the eleventh edition of the. Cosumnes River Journal, an annual… Read more Cosumnes River Journal 2017 Celebration


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Create beautiful tile installations. BMC stocks floor and wall tiles in a variety of materials, from synthetic vinyl to natural stone, in a gorgeous array of colors.
Ease the installation process and keep your project looking like new for years to come with BMC's stock of underlayment, tile spacers, sponges, and other tools.
BMC carries tile grout in sanded and unsanded varieties, in a rainbow of colors to complement any interior design.


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SINISTER (Scott Derrickson, 2012)
novelist Ellison Oswalt (Ethan Hawke) has a habit of getting on the bad
side of local law enforcement wherever he goes. In SINISTER his latest
project does little to endear him to the community. Ellison is
researching the case of a girl who went missing after her parents and
two siblings were hanged from a tree in their backyard. In a ghoulish
decision, the out-of-town author moves his family into the victims'
home, although his wife Tracy (Juliet Rylance) and two kids are unaware
of the house's recent history.
the attic Ellison finds a box of 8mm home movies. The labeled cases
feature innocuous titles for the films, but when Ellison fires up the
projector to watch them, he discovers horrifying documentation of the
murders he's investigating as well as footage of other ritually
slaughtered families. The deeper Ellison sinks into his work, the more
he struggles to shake the horrible images he's witnessed. Eventually he
turns to a starstruck deputy (James Ransone) for assistance in gaining
information about the larger story he's stumbled upon.
functions as an unnerving testament to the power and pull of the moving
image. Ellison obsessively watches the home movies, poring over every
frame for clues regarding the location and people involved in the
killings. Although he's doing a careful reading of the text from an
objective distance, he is still susceptible to being affected by what
passes before his eyes. Ellison is not a film critic in that he is not
rendering approval or disapproval on the movies' aesthetic values, but
he is practicing the kind of dedicated engagement with the work that
marks the cinephile.
interpretation aside, it's a scary movie. Director and co-writer Scott
Derrickson mixes in a modicum of jump scares while maintaining an
enduring state of uneasiness. The horror doesn't come from anticipating
a supernatural being leaping out of dark corners or seeing graphic
violence. For Ellison and the audience the terror comes in having
what's suggested in the flickering images seared into one's
consciousness. Swaying bodies dangling from a branch and the hint of
mutilation are hard to shake from the mind's eye. Even when what's
depicted is not especially vivid, the persistence of the visions are.
isn't to be mistaken for a novel entry in the genre. It owes more than
a debt of gratitude to THE SHINING and THE RING, among others, but
Derrickson processes the chilling influences into an eerie experience
mindful of the significance of projected images watched alone in the
Grade: B


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Halloween decor
On my mind this Monday is how happy I am to have gotten my Halloween decor up and out all over the apartment. It's a holiday I love to decorate for. And this year I actually have it all already up. I'll get to enjoy it for two full weeks before it's time to take it all down. My coffee filter wreath got a new look for this year.
Halloween decor
I got the ledges started and the spider web's along the top are just an addition from picmonkey. But it does give me idea's for what to add to them for next year. 😉
I had shared my skeleton frame with you all on my instagram.
Do you follow me there?
This chalkboard frame got another revamp. I had first revamped this frame in Thrift Share Thursday no 17. So I wanted to change it up so I could display a little more Halloween dollar store decor.
Some glittery and flashy wrapping paper.
One dollar store skull.
Some dollar store tape and this skull display is now a part of my 2015 Halloween decor.
I love witches. So whenever I find a cute sign with one I always pick it up.
Do you decorate for Halloween? Have you done it yet or intend to wait till the day before?
ps – see my Links party page for where I party & share my projects