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As someone who released his first album the same month Facebook was launched, Kanye West knows it's time for a status update. The rapper hit the skids following an infamous tirade against Taylor Swift at last year's MTV Video Music Awards and bottomed out soon after when President Obama called him a "jackass" in an off-the-record portion of an ABC interview. Now, a year and 1.6 million Twitter followers later, he's returned from hiding (in Italy, apparently) and is back in our faces. "They say I was the abomination of Obama's nation," Kanye rhymes, cleverly, on his fifth album, My Beautiful Dark Twisted Fantasy (out Nov. 22). He never refers explicitly to the awards show moment, but other lines, like "I went from the favorite to the most hated," clearly refer to that fiasco. Before anyone starts thinking West's been humbled, though, he also asserts, "I got the power to make your life so exciting" and mercilessly proposes "a toast for the scumbags" around him. And in yet another track, he merrily tells us how he met, married, and divorced a porn star all in one night.
What, you were expecting consistency from Kanye West? As a thinker, producer and record maker, he's always been all over the map, and his public flogging since the Swift incident (and his recent, awkward apologies to George Bush for implying he was a racist after Hurricane Katrina) have only further muddled his message. Anyone expecting a full-throttle apology to Swift, or more detailed elucidation into what transpires in his brain, won't necessarily find them on My Beautiful Dark Twisted Fantasy; the quotes above are about as self-reflective as he gets here.
Still, Kanye remains consistent where it counts: in his music. Back to the days of "Jesus Walks," he's never been afraid to think big as in, creating songs of epic proportions and he's not about to stop now. My Beautiful Dark Twisted Fantasy, his most extravagant work, is hip hop's version of grand opera: a congested, constantly bustling disc stuffed with oversized drama, guest rappers, insanely eclectic samples (best example: '70s prog rock icons King Crimson on "Power"), and backup vocals from a list of headliners that includes Alicia Keys, Elton John, and Fergie. (Taylor Swift may be the only major act who didn't make the sessions.) Tracks like "Dark Fantasy" and "So Appalled" are built on rumbling tanks of pianos and strings that sound as if West is marching into the apocalypse. On paper, "All of the Lights," which hints at blinding stardom, should be a mess: Between its trumpet-processional fanfare, Elton John piano, and Rihanna-sung hook, it should capsize before our ears. Instead, it's powerful and panoramic a validation of what West calls his "bravery in my bravado."
In our mashup-heavy pop music world, in which no one finds it abnormal when Weezer's Rivers Cuomo guests on a rap record, genre juxtapositions are old news. But My Beautiful Dark Twisted Fantasy reasserts the fact that few combine disparate elements as smoothly as West. Both "Lost in the World" and "Runaway" the latter a nine-minute track addressed to someone who's been "putting up with my s--- too long," integrate the supple vocals of Bon Iver singer Justin Vernon. The unexpected results are elastic, shimmering soundscapes that pinpoint a common ground between the hardness of hip-hop and the sweetness of indie rock. Those two songs also feature prominently in the 35-min. video for "Runaway" that preceded the album. In what amounts to another homage to West's audacity of dope, he almost runs over a female alien who's crashed to earth, then takes her home, seduces her, watches helplessly when his friends find out what she really is, and gazes as she/it rises, phoenix-like, to the sky. (Yes, he identifies with her outcast fate.)
Naturally, West can't help but overdo it, as he did on his previous effort, 808s and Heartbreak. There, he insisted on trying to prove he can sing when he really can't. Here, too many guest rappers keep crowding him out, diluting whatever lyrical coherence the album may have had. "Blame Game" is that rare, effortless fusion of penthouse-boudoir R&B and hip hop grit until it segues into an interminable, decidedly unfunny skit in which a guy keeps asking a woman how she learned such mind-boggling bedroom moves. ("Yeezy!" she keeps responding, referring to West's nickname.) Yet for most of the album, West turns the chaos of his life into art, instead of just more Internet-mockery fodder.


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TerryGroup8 necesitaba un nuevo diseño de logotipo y lanzó un concurso de diseño en 99designs.
Un ganador ha sido elegido entre 22 diseños de 8 diseñadores freelance.
Logo Design adapted from existing company that has an established logo font style, Berkely Book.
A longstanding company that sells windows and doors is creating a new division in their company for a Handyman service. The men who do installation already have the skills to do odd jobs around the house, so now we are going to offer this Handyman service in addition to Windows and Doors.
We do not want a totally new design, rather we want an adaptation of the existing design. The font style is Berkely Book. You can see it on the website, http://www.mrrogerswindows.com
The new logo needs to read:
Mr. Rogers Handyman
Only the words Mr. Rogers need to be in Berkely Book. The blue color is PMS 300.
Acceptable objects might include a tool box, a tool belt, or a group of tools. No object is necessary, it can just be an adaptation of the logo font.
You can also use an adaptation of the standing "character" we use as a sign outside the home when we are working there. To see the sign/logo, you can go to this page: http://www.mrrogerswindows.com/99permonth/
- Item 1... Must use Berkely Book Font for words: Mr. Rogers
- item 2... Must use PMS 300 for Mr. Rogers font
- item 3... Must provide finished files in vector art immediately upon selection- prompt payment provided
- Item 1...
Descubre cómo funciona un concurso de diseño u obtén más información sobre nuestros servicios de diseño de logo.

subset: commoncrawl


text:
Hodkin & Jones (Sheffield) Limited01246 290888
Established in 1868,Hodkin and Jones manufacture a range of fibrous plaster,GRG, and GRP mouldings for interior and exterior decoration.
Our contracts division supply and fix standard and bespoke mouldings which include column casings,domes,fascia and bulkheads, match to exisitng on listed buildings and restoration of decorative ceilings to historic properties approved to English Herritage requirements.
Our GRP department manufacture exterior architectural mouldings that have the strength and low maintenace qualities in white, stone effect or pigmented to your choice of colour or texture. Quick and easy to install, offering a modern and economical alternative to natural materials
Our standard range of products included
cornices,centre pieces, panel and dado,niches, fire surrounds,door surrounds,arches and corbels,decorations, and columns,
Our GRP department also have a extensive range of door and window canopies, fascia,door surrounds columns and porticos and also offer a bespoke service.
Getting in contact with Hodkin & Jones (Sheffield) Limited
Callywhite Lane
Tel: 01246 290888
Hodkin & Jones (Sheffield) Limited Products & Services
- Plaster > Mouldings
- Plaster > Mouldings > Arches
- Plaster > Mouldings > Cornices
- Plaster > Mouldings > Dado Rails
- Plaster > Mouldings > Fire Surrounds
- Plaster > Mouldings > Gypsum
- GRP > Mouldings > Chimney Caps
- GRP > Mouldings
- GRP > Mouldings > Door Surrounds
- GRP > Mouldings > Dormers
- Decorative > Products
- GRP > Products


text: BUSINESS Lionsgate acquires 'Cruelty' 5:43 PM PDT 5/23/2008 by Carolyn Giardina , AP FACEBOOK TWITTER EMAIL ME Quirky script written by first-time screenwriter Adam Sachs Lionsgate has acquired worldwide rights to "Stop Huntingdon Animal Cruelty," a spec script by first-time screenwriter Adam Sachs.The script -- described as a quirky, elevated comedy in the vein of "Thank You for Smoking" -- centers on an unlikely friendship between a lonely reporter and an outspoken teen who bond during an animal-rights protest.Sachs graduated from Harvard last year with a major in earth and planetary science; and had been writing for the Harvard Lampoon. The writer said he penned a humor piece for a Web site that caught the attention of Energy Entertainment's Adam Marshall. "He loved it, and helped me develop a spec," Sachs said.Producing are Brooklyn Weaver of Energy and Todd Garner of Broken Road Prods. Marshall and Sean Robins of Broken Road also will serve in producing capacities.Lionsgate vp production Jim Miller is overseeing the project for the company.Sachs is repped by WMA and Energy. FACEBOOK TWITTER EMAIL ME Carolyn Giardina email@example.com CGinLA AP firstname.lastname@example.com @thr


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Jana Rickert
I was one of the students who was late signing in for the International Business Administration (IBA) programme at the University of Twente, because I didn't know anything about it before. Luckily a third-year IBA student did his internship in my hometown and happened to know a friend of mine. We met and he told me about this great campus university which is unique in the Netherlands. His enthusiastic story, his explanations about the programme and the fact that he was doing an IBA internship and was about to spend a semester abroad in Budapest afterwards, caught my interest. This was exactly what I was looking for.
The Open Day I visited, was a great experience. The weather was beautiful and the campus was at its brightest. I was impressed by the amount of sports facilities, the modern buildings, systems and architecture of the whole campus, the overall wealth of nature, and the kindness and openness of the people I met. Even my grandma, who came with me, said if she had been young again she would have studied here too. The description of the study programme also seemed to meet my expectations, so I signed up soon after!
So far, my experience of studying at the University of Twente has been very positive. IBA is a very good and interesting programme and offers project-based working, which is very close to real-life practice.
The university has also great study areas and rooms for groups or just for one person, to make sure everyone has a quiet place to study.


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The past few months have been a whirlwind. I have had a complete career change, I decided to say no to the bright future in teaching, and take a gamble on the blogging world. I have found Instagram to be an incredible networking platform, and I have met many marvellous creative people including the one and only Sapphire! I got a chance to catch up with the owner of the Flower Arranger and mastermind behind the Coven.
Hello, Hello, Hello! So lets hear a little bit about you first, so you and my readers aren't strangers!
I'm Sapphire, I am twenty-four. I don't have much time for hobbies because I work so much, but I love boxing and try to go four times a week, I also LOVE visiting new countries and exploring. My idol is Bill Murray and I'm definitely not a typical florist or business-woman.
So lets talk "The Flower Arranger", how did it all begin?
The Flower Arranger came to life two years ago when I was staying in Thailand with no job and slowly running out of money. I had trained as a florist at my previous job but just wasn't built to work for other people (it's the Aquarius in me). So I just decided to say 'fuck it', my life motto, and set up a website advertising myself as The Flower Arranger.
That life motto is everything! I think I need a little Aquarius in me, but I'm too much of a stubborn Pisces. As well as your amazing flower arranging business, you also run a group called The Coven Girl Gang, which I am honoured to be apart of. For my readers what exactly is the Coven?
The Coven is an online and IRL platform with powerful, creative business women who want to grow their businesses, whilst connecting and supporting a whole load of badass women similar to themselves. It is still in its very early stages – we haven't officially launched yet or even finished the website but we're getting close!
The Coven is an amazing resource and has allowed me to connect with so many amazing creative! How does the Coven help fierce women in the world of business?
When you work by yourself no matter how strong and fierce you are you can sometimes feel lonely – there isn't always someone around to discuss your ideas with or to make you feel supported. That is where our community comes in. I provide members with a safe online space to chat with likeminded individuals about anything and everything. When we officially launch there will also be video content from industry experts on various different key aspects of business to help you grow and strengthen your skill set.
I admire this so much. It's not addressed enough that there isn't a whole lot of help for Freelancers, and individual businesses. I have found that working for yourself is challenging, but at the same time it allows so much freedom! What Inspired you to set up The Coven?
I felt lonely working by myself all day long, I wanted to connect with other people who just GOT IT. I also have noticed that as someone working in the creative industry that quite often us creatives are so in love with the art that we create that we really don't like to focus on the 'boring' stuff like accounts and admin, but these are key aspects of running a business that we need to learn in order to grow a big profitable business and keep creating the art that we love.
That is true, accounts and anything with numbers scares me! Aswell, joining the Coven has made me feel less alone, and has lit a fir under my ass to do more! What would you tell someone who's family didn't really understand their dream to work freelance?
You will either support me or you won't. I'm a very to the point person and I just think some people will understand why you do what you do and others will just think you are fucking crazy and that's life.
I would tell the person in question that just because their family doesn't understand it doesn't mean they shouldn't chase their dream. They should get their asses into The Coven where they can feel supported.
If you could give someone one piece of advice to setting up their own business/ work freelance what would it be?
Fucking do it. There are a million reasons why you shouldn't and a million perfectly valid obstacles in the way but there is never the perfect time to go it alone. It's a bumpy road but the sooner you start, the sooner you achieve your dreams.
Agreed, we only live once, so ceasing the day is important! No point waiting around. One last little question, who is your female inspiration at the moment?
That is a really difficult question! I don't think I have one specific female inspiring right now apart from my Mum. The online community and camaraderie shown by female creatives online currently inspires me. Women are really coming together and supporting each other at the moment and you can really see that on platforms like instagram. I love it.
Me too! The amount of support demonstrated on social media is epic! Mums are definitely the best! My Mum inspires me everyday and even got me to join a tap dancing class!
People like Sapphire, and the many other fantastic creatives I have met through different platforms inspire me. My blog has definitely opened doors for me, and allowed me to connect with the most fabulous women, and creators! If you're thinking of blogging or starting your own business, in the words of Sapphire "Fucking Do It!" There's nothing holding you back!
Go Follow Sapphire:


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It is tempting to think that with advances in technology that we don't really need
-live lectures and tutorials. Students can just watch videos of the worlds best lecturers
at their convenience and in the comfort of their home. Tutorials can be done online, i.e. MOOCs.
-conferences. they can be done virtually with video conferencing.
-for students doing non-experimental Ph.Ds to ever come on campus.
-visits to collaborators. It can be done via email and Skype.
This will save lots of money and time (and carbon footprint), particularly that associated with international travel.
But, we should be nervous that the loudest proponents of these initiatives are mostly
politicians, neoliberal "managers", and commercial outfits, most of whom are not (and sometimes never have been) actual teachers or researchers.
With regard to collaborations, I continue to be surprised at how effective personal visits and informal discussions are. Even when it is not clear to me that a face to face meeting is necessary, things usually get moved forward significantly, sometimes in unanticipated directions.
I should also say that some conferences and visits are not particularly productive. But, I think it is hard to predict these things in advance. Again, often the significant events are new insights from "random" interactions.
I have been at a few conferences where some "big shot" did not personally attend but gave a talk via a video link. At worst, it was a complete waste of time. At best, it was a marginal contribution to the meeting. It never had the same engaging dynamic as when the speaker is actually physically present in the room.
I think we are blessed with these technological innovations and they do have a role to play. But, it is a limited role. Furthermore, they are most effective when there is already a strong personal relationship between highly motivated individual parties and the common project is well defined. Mostly the technologies enhance and complement old fashioned "face to face" methods.
It is interesting [weird] that I have co-authored several papers with people I have never personally met. But, it is also noteworthy that this has just been one or two papers, and there has been no long term collaboration.
I think ultimately an individuals view on these matters is determined by deep underlying (and often unquestioned) anthropological assumptions. What is the nature of humanity? Are people "economic units", "biological machines", "social animals", or is there something intrinsically and profoundly relational at the heart of who we are?
Tuesday, November 11, 2014
The personal touch
Posted by Ross H. McKenzie at 3:30 PM
Labels: collaboration, politics, teaching, technology
Subscribe to: Post Comments (Atom)


text: Committed to HEAD. Thanks, Kurt At 12:17 AM 12/12/00 +0000, firstname.lastname@example.com wrote: >Regarding ITS #916 - Suggestion to add UTF-8 to Wide Char or Multibyte conversion routines. > >I added documentation to the previous submissions and cleaned up a bit. >Updated files FTP'd to /incoming directory. > steck001211utfconv.c > steck001211ldap_utf8.h > >Dave Steck 801-861-5219 >Novell, Inc., the leading provider of Net services software


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1. Upload and install the plugin via the WordPress plugin installation routine:
2. After activating the plugin, you will be redirected to the checkout options page:
3. Enable the payment method
4. Enter your Block.io API keys for the currencies you want to accept in your store
Note: HD Wallet add-on users enter their extended public keys in the HD Wallet settings tab instead.
5. Configure cron:
CryptoWoo's order processing and exchange rate updates rely on WP-cron, the built-in cronjob service of WordPress.
The speed of the payment processing is directly dependent on the execution of WP cron.
The disadvantage of WP-cron is that it's only triggered if there are visitors on your website. This could lead to infrequent exchange rate updates from the cryptocurrency exchanges.
To ensure that the updates are triggered as defined, you should set up a cronjob at your hosting provider to hit
wp-cron.php at a regular interval. Please see the tutorial at Harish Chouhan's article on Wptuts+.
To speed up the payment processing you have to get below the 1 minute granularity of the crontab. You can set up 4 crontasks that are executed every minute and let the 2nd, 3rd, and 4th cronjob sleep for 15, 30, and 45 seconds before they trigger WP cron. This results in a 15 second interval between each WP cron execution instead of one minute when using only one crontask.
Check the "Database Actions" page in your CryptoWoo admin backend for crontask examples.
6. Go to Database Actions:
7. Update the exchange rates once manually
Done! Your WooCommerce store is now ready to accept digital currencies with CryptoWoo!
Please do not hesitate to submit a ticket if you're experiencing any problems!


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Deeds Goes Up on Air
Gubernatorial candidate R. Creigh Deeds has been saving his pennies, while his Democratic rivals Terry McAuliffe and Brian Moran have been spending at a fast pace. Now we know why.
Deeds began airing two TV ads today in four markets -- Hampton Roads, Richmond, Roanoke and Bristol -- in Virginia. McAuliffe has aired ads on and off for months, but Moran has not aired any.
See below to watch Deeds' two new ads:
The first ad, "Education Story," touts Deeds' proposal to rebuild Virginia's economy by investing in education.
The second ad, "Most Qualified," discusses Deeds' record and his proposal to rebuild the economy with investments in transportation, local schools and higher education.
Anita Kumar
May 4, 2009; 11:45 AM ET
Categories: 2009 Governor's Race , Anita Kumar , Creigh Deeds , Election 2009 , Terry McAuliffe
Save & Share: Previous: Bill Clinton Steps Into Arlington Delegate Race
Next: Is McDonnell Looking to Wilder for Support?
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The comments to this entry are closed.


text:
Diagnosing, Preventing, and Treating Illness and Disease in AdultsLearn More
The Underlying Causes of What Ails YouLearn More
Preventing the Onset of Illness and Age-Related DiseasesLearn More
A Comprehensive Approach to Weight LossLearn More
At Rita N. Oganwu, MD SC, we are about wellness and health maintenance. We treat the whole body by correcting physical and metabolic symptoms associated with aging, as well as hormonal and nutritional imbalance.Read More
Rita N. Oganwu MDSC is board certified in Internal Medicine, Geriatrics, Clinical Science of Anti-Aging and Regenerative Medicine, and Homeopathy Medicine. She is a member of the American Society of Bariatric Physicians and has been practicing medicine for over 25 years.Learn More


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High expectations have been the norm for the former five-star prospect who garnered comparison to Archie Manning when he first showed up at Ole Miss. He's capable of shouldering the pressure that comes from a team's lofty goals, but heaping all those hopes on him in unrealistic. Michigan got one answer it needed in order to improve; it has several others it needs to provide on its own.
Forte, a versatile, workmanlike running back who was a two-time Pro Bowl selection, rushed for 8,602 yards and 45 touchdowns and had 4,116 receiving yards and 19 touchdowns over eight seasons with the Bears from 2008-15. He set an NFL single-season record for running backs with 102 catches in 2014.
Hester played his final season in 2016 with the Ravens. Forte played for the Jets in 2017 and announced his retirement in February.
Willson Contreras doubled to start the eighth, but Olson got pinch-hitter Victor Caratini on a groundout and struck out Kyle Schwarber.
Nick Goody struck out Addison Russell to end the eighth before Allen worked the ninth.
Elite Kids Marcus Williams Jersey
The teams split the two-game series in their first meeting since the 2016 World Series that saw Craig Robertson Jersey the Cubs win Game 7 at Progressive Field for their first championship since 1908.
There's nothing to be upset about, Cubs manager Joe Maddon said. They just got us today.
Baez got the best of good friend Lindor in the seventh inning just before Miller entered the game.
First and foremost, the feel of these PJs is just what you'd want in sleepwear — soft with enough room and breathability to feel comfortable lounging and sleeping in for the night. I'd throw them on for hours even before I hopped into bed because they were so comfy. Plus, they're tagless, which I loved. Aside from when I was scratching an itch on my arm or leg, I didn't notice the print on the inside (when scratching, it felt a tad rough on the skin).
Darqueze Dennard Youth Jersey
I wasn't waking up from being too hot in the long sleeves and long pants, but I did toss and turn a bit through the night. It wasn't a completely sound sleep.
I also didn't love the fact that I couldn't technically measure the effect the pajamas had on my recovery. Because I'm not a professional athlete and I don't own any high-tech machines or administer blood tests that can check my hormone and energy levels, I was able to measure the pajamas' effect only based on how I felt and my soreness level.
Another setback for the average consumer: the price tag. The sleepwear costs $100 for the top and $100 for the bottom, and for most, $200 is an investment for a pair of pajamas.


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Alex Crossan (born 5 April 1996), also known by the stage name Mura Masa (sometimes stylised as mura masa) is a Guernsey-born electronic music producer, songwriter and multi-instrumentalist.[1][2] His stage name is taken from Japanese sword-smith Muramasa Sengo.[3]
He is best known for his song "Lovesick", which reached number 1 on the Spotify Viral charts in the United Kingdom and the United States.[4] He also produced and co-wrote "First Things First" on Stormzy's Gang Signs & Prayer, which entered the UK Albums Chart at number 1 on 3 March 2017. The track also entered the singles chart at number 25. On 14 July 2017, he released his debut album Mura Masa, which has been nominated for two Grammy Awards, including Best Electronic Album and Best Recording Package. He is the first artist to be nominated as both a musician and creative director for the same album.


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Expanded Polystyrene (EPS) is lightweight foam used for packing. Being 98% air is can be compressed for recycling. Household quantities of polystyrene can be dropped off for FREE recycling at the Dunmore Recycling and Waste Disposal Depot and Tuncurry Waste Management Centre.
Dunmore Recycling & Waste Disposal Depot
57 Buckleys Rd, Dunmore NSW 2529
02 4237 5193
Opening Hours
7.30am to 4pm, Mon – Fri
8am to 4pm, Sat – Sun
(closed Good Friday & Christmas Day)
Tuncurry Waste Management Centre
Midge Orchid Road (Tip Road), Tuncurry NSW 2428
02 6554 9471
Opening Hours
8am to 4pm, 7 days a week
(closed Good Friday & Christmas Day)


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This just has to be my favourite time of year. There's nothing more satisfying than sharing bargains and deals with you lovely folk. Today there is an absolute abundance of sales, and we plan on sharing them with you. Debenhams is one of the High Street retailers that we all LOVE and today they have launched their "boxing day" sale. Plus use the Debenhams promo code SHAJ at the checkout and get FREE delivery too, no minimum spend!
Beauty/Fragrance/Gift Sets*: Philosophy Amazing Grace Layering Set* Now only £17.50. Paco Rabanne 1 Million Gift Set* Now £27.66.
Childrenswear*: Olaf Trapper Hat* Now £9.60. Blue Zoo Pack of Two Pyjamas* Now £9. John Rocha Faux Fur Gilet Dress*Now From £14.
There really are lots of bargains to be found. The stock availabilty across the site is very promising and to be honest is much better than that of Boots.com. So, if you have seen something on the Boots site but it's out of stock then try looking for it on here. Debenhams doesn't tend to be the cheapest but the sale is fab and a lot of the reductions are the same (on the fragrance & beauty) as Boots.
Remeber to use that code when at the checkout to ensure that you get FREE delivery.


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Jeep Commander Headlight Bulbs, Aftermarket Fog Light Bulbs
Jeep Commander Headlight Bulb Information
Jeep Commander Headlight Bulb choices are plenty. Once you decide you're ready to install some aftermarket light bulbs, there are many options to consider in choosing the perfect replacement headlight bulb for your Commander. Headlight Bulb replacements are available in a variety of brands, wattages, and colors, with each set of headlight bulbs being ideal for a particular purpose.
Our line of Jeep Commander headlight bulb carry thru 2006, 2007, 2008, 2009, 2010 or 06, 07, 08, 09, 10 models.


text:
Join a Winning Team
With the entrepreneurial capacity to service local markets and appeal to unique demands, Sutton REALTORS® enjoy the best personal net income opportunity in the industry!
A dynamic team of committed, full-time Real Estate Professionals is the foundation of our "FULL SERVICE" real estate firm. Our "Best Sellers" rank with the finest across the continent. Our state-of-the-art offices, combined with our exceptional administrative support staff ensure competent attention to all your needs.
Comprehensive training and management assistance are our number one priorities. We are actively recruiting both experienced and newly licensed REALTORS® who embrace customer service and technology as part of their daily business. Sutton – Select provides a full range of client and REALTOR® services, combining the power experience, expertise and leadership that delivers SELECT service with the simplicity of effective action.
The Sutton – Select Advantage
- Join our SUTTON – SELECT First-Class Team
- Six-Figure Average Income Annually per Agent
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Opportunities and Flexibility to Manage Expenses/Receive Extensive Benefits
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Market Topics and Trends/Canadian-Based Content (not US-Based)
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- Complimentary Loading of MLS listings
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- Comprehensive Marketing Department for your Newsletters, Just Sold/Listed Cards,
Client Presentation Packages, Flyers and More…
- Social Media Department
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- Welcoming Reception Area
- Private and Shared Offices Available
- Inviting Open Concept Work Lounge with Multiple Computer Work Stations and Comfort
Zones that Promote Networking, Engagement and Collaboration
- Executive Board/Presentation Room
- Multiple Technology-Equipped Client Conference Rooms
- Complimentary Wi-Fi
- Welcoming Reception Area
- Complimentary Refreshment Station for Clients and Team Members
- Innovative and Interactive Company Website
- Personalized Individual Agent Web Pages
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No more high monthly fees! No more high transaction fees! Sutton Group – Select Realty Inc. REALTORS® only pay for what they need… and no more!
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519 433 4331 Office
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Dylan Sworik, Broker of Record
519 433 4331 Office
226 448 9880 Mobile


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21 May
As a first-time Mother, I didn't realise how much my own routine would be thrown out of whack by setting up my mini-kind's sleep-eat-play habits.
Before my son was born, I had a regular skincare routine, exfoliated weekly and made sure I put on body lotion everyday. Oh how that has changed. It's not that I don't care, I do. I'm just time-poor most-mornings in between getting a sippy cup full of milk and changing a dirty nappy plus managing to squeeze in a hot coffee. And I'm exhausted at night.


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|Hepatic Cell News 1.00 January 20, 2017
Circadian- and UPR-Dependent Control of CPEB4 Mediates a Translational Response to Counteract Hepatic Steatosis under ER Stress
Researchers showed that cytoplasmic polyadenylation element-binding (CPEB) 4 is required for adaptation to high-fat-diet- and ageing-induced endoplasmic reticulum (ER) stress, and subsequent hepatosteatosis. Combined transcriptional and translational Cpeb4 regulation generated a 'circadian mediator', which coordinated hepatic unfolded protein response activity with periods of high ER-protein-folding demand. [Nat Cell Biol] Abstract
(Ranked by impact factor of the journal)
Metformin Inhibits Hepatic mTORC1 Signaling via Dose-Dependent Mechanisms Involving AMPK and the TSC Complex
The authors showed that metformin robustly inhibits mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) in mouse liver tissue and primary hepatocytes. Using mouse genetics, they found that at the lowest concentrations of metformin that inhibit hepatic mTORC1 signaling, this inhibition is dependent on AMP-activated protein kinase (AMPK) and the tuberous sclerosis complex (TSC) protein complex (TSC complex). [Cell Metab] Abstract | Graphical Abstract
Farnesoid X Receptor Ablation Sensitizes Mice to Hepatitis B Virus X Protein–Induced Hepatocarcinogenesis
Scientists showed that hepatitis B virus X protein (HBx) can interact with farnesoid X receptor (FXR) and function as a coactivator of FXR. In vivo, FXR ablation markedly sensitized mice to HBx-induced hepatocarcinogenesis. [Hepatology] Abstract
An Endoplasmic Reticulum Protein, Nogo-B, Facilitates Alcoholic Liver Disease through Regulation of Kupffer Cell Polarization
Since endoplasmic reticulum (ER) stress is known to induce M2 macrophage polarization, the authors examined whether Nogo-B regulates M1/M2 polarization of Kupffer cells and alters the pathogenesis of alcoholic liver disease. Nogo-B in Kupffer cells promoted M1 polarization, whereas absence of Nogo-B increased ER stress and M2 polarization in Kupffer cells. [Hepatology] Abstract
The Microbiota Maintain Homeostasis of Liver-Resident γδT-17 Cells in a Lipid Antigen/CD1d-Dependent Manner
Investigators showed that hepatic IL-17A-producing γδ T (γδT-17) cells are liver-resident cells and predominant producers of IL-17A. The microbiota sustained hepatic γδT-17 cell homeostasis, including activation, survival and proliferation. Liver-resident γδT-17 cell homeostasis depended on hepatocyte-expressed CD1d, that presented lipid antigen, but not Toll-like receptors or IL-1/IL-23 receptor signaling. [Nat Commun] Full Article
The microRNA-449 Family Inhibits TGF-β-Mediated Liver Cancer Cell Migration by Targeting SOX4
Researchers demonstrated that the microRNA-449 family acts as tumor suppressor in liver cancer by causing cell death and inhibiting cell migration. These effects were caused by downregulation of the oncogene SOX4, which is frequently overexpressed in liver cancer. [J Hepatol] Abstract
RIPK1 Protects Hepatocytes from Kupffer Cells-Mediated TNF-Induced Apoptosis in Mouse Models of PAMP-Induced Hepatitis
Scientists investigated the role of the receptor interacting protein kinase 1 (RIPK1), a protein known to regulate cell fate decisions, in the death of hepatocytes using two in vivo models of pathogen associated molecular patterns (PAMP)-induced hepatitis. Whereas RIPK1 deficiency in liver parenchymal cells did not trigger basal hepatolysis, it greatly sensitized hepatocyte to apoptosis and to liver damages following single injection of lipopolysaccharide or CpG oligodeoxynucleotide. [J Hepatol] Abstract | Graphical Abstract
Disrupting Hepatocyte Cyp51 from Cholesterol Synthesis Leads to Progressive Liver Injury in the Developing Mouse and Decreases RORC Signaling
The authors identified a global and sex-dependent transcriptional de-regulation due to the block in cholesterol synthesis during development of the Cyp51 knockout mice and provided in vivo evidence that sterol intermediates downstream of lanosterol regulate the hepatic RORC activity. [Sci Rep] Full Article
Activation of Wnt/β-Catenin Signaling via GSK3 Inhibitors Direct Differentiation of Human Adipose Stem Cells into Functional Hepatocytes
Investigators suggested that activation of Wnt/β-catenin signalling via glycogen synthase kinase 3 (GSK3) inhibitors in definitive endoderm specification may represent an important mechanism mediating human adipose stem cells differentiated to functional hepatocyte. [Sci Rep] Full Article
MicroRNA-145 Promotes Activation of Hepatic Stellate Cells via Targeting Krüppel-Like Factor 4
Researchers aimed to characterize miR-145 and Krüppel-like factor 4 (KLF4) in activated hepatic stellate cells (HSCs) and liver cirrhotic, and the underlying molecular basis. miR-145 was significantly up-regulated, while KLF4 was dramatically down-regulated during the activation of rat primary HSCs and TGF-β treated HSCs. [Sci Rep] Full Article
Biology and Function of Glypican-3 as a Candidate for Early Cancerous Transformation of Hepatocytes in Hepatocellular Carcinoma
The authors summarize current knowledge regarding the clinical aspects of glypican-3, while also synthesizing the current literature with the aim to better understand this molecule's biological interactions at a molecular level, not only in the liver, but in the rest of the body as well. [Oncol Rep] Abstract
Visit our reviews page to see a complete list of reviews in the hepatic cell research field.
NeuroVive Presents Positive Preclinical Data in Hepatocellular Cancer at HCC Summit
NeuroVive Pharmaceutical AB announced that an abstract with novel preclinical cancer data related to the company's sanglifehrin-based compounds has been accepted for presentation at a scientific conference. [Press release from NeuroVive Pharmaceutical AB discussing research to be presented at the 2017 European Association for the Study of the Liver (EASL) Hepatocellular Carcinoma (HCC) Summit, Geneva] Press Release
Can-Fite Receives IRB Approval to Commence Patient Enrollment in Phase II NAFLD/NASH Trial in Q1 2017
Can-Fite BioPharma Ltd. announced it has received approval to commence patient enrollment in a Phase II study of its liver drug candidate Namodenoson in the treatment of non-alcoholic fatty liver disease, the precursor to non-alcoholic steatohepatitis. [Can-Fite BioPharma Ltd.] Press Release
European Commission Grants Marketing Authorization for Gilead's Vemlidy® (Tenofovir Alafenamide, TAF) for the Treatment of Chronic Hepatitis B Virus Infection
Gilead Sciences, Inc. announced that the European Commission has granted marketing authorization for Vemlidy®, a once-daily tablet for the treatment of chronic hepatitis B virus infection in adults and adolescents. [Gilead Sciences, Inc.] Press Release
Billion-Dollar Project Aims to Prep Vaccines before Epidemics Hit
SARS, Zika, Ebola – when some of the world's most terrifying disease outbreaks occur, health workers often find themselves powerless. A billion-dollar initiative aims to change that situation by pre-emptively developing and stockpiling vaccines to combat potential epidemic threats. [Nature News] Editorial
Mystery as Controversial List of Predatory Publishers Disappears
A popular blog that lists "potential, possible, or probable predatory" publishers and journals has disappeared, but it is not clear why. A University of Colorado in Denver spokesperson told ScienceInsider that Beall made a "personal decision" to take down his list of low-quality journals that charge authors a fee to publish, often with little or no review or editing. [ScienceInsider] Editorial
NEW The European Association for the Study of the Liver (EASL) Hepatocellular Carcinoma (HCC) Summit
NEW Keystone Symposium: Lipidomics and Bioactive Lipids in Metabolism and Disease
Visit our events page to see a complete list of events in the community.
NEW PhD Studentship – Hepatocytes (KU Leuven, Stem Cell Institute)
NEW PhD Position – Pathogens Infecting Liver (Helmholtz Association)
NEW PhD Studentships – Liver Organ Growing (Downstate Medical Center)
NEW Postdoc/Research Associate – Liver Cancer (Icahn School of Medicine at Mount Sinai)
NEW Research Scientist – Liver Diseases (Gilead Sciences)
NEW Postdoctoral Research Fellow – Liver Genetics (National Jewish Health)
NEW Postdoctoral Research Fellow – Liver Cancer (Fred Hutchinson Cancer Research Center)
NEW Senior Scientist – Oncology (Genentech Research)
NEW Training Fellowship – Clinical Research (University of Oxford)
NEW Postdoctoral Associate – Cancer Biology (University of Florida)
Recruit Top Talent: Reach potential candidates by posting your organization's career opportunities on the Connexon Creative Job Board at no cost.
Have we missed an important article or publication in Hepatic Cell News? Click here to submit!
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Driven by the inexorable rise of web-based services in the digital age, data centres – effectively giant racks of servers and digital storage capacity – begin to place an increasingly significant load on national power systems. Clearly this demand will continue to show dramatic growth in the coming years. Industries such as the medical and healthcare sector are increasingly outsourcing data services, commercial transactions through web-based retailers and the financial services sector are soaring and consumer services such as streaming video are all contributing to spectacular growth in the number of data centres and their use.
While tablets, laptops and phones may appear to consume relatively little power, collectively the IT infrastructure required to support them represents a major source of power demand. Doug Alger, Cisco IT Architect, told e-tech: "Data centres are unique environments because you have a significant amount of power density within them – a room filled with cabinet after cabinet of computing equipment".
US-based environmental NGO, the Natural Resources Defense Council (NRDC), found data centres alone consumed upwards of 91 TWh in the US in 2013.This figure is expected to increase by more than 50% by 2020 to roughly 140 TWh, the equivalent annual output of 50 power plants. Putting this into perspective, the US generated around 4100 TWh in 2013.
With data traffic set to triple in three years, according to Lux Research analysis, data centre demand for energy and corresponding cooling capacity is set to follow close behind. The research firm calculates that for each 100 W of server capacity power demand, some 50 W of cooling capacity is required. The demand for cooling equipment, already worth USD 1 billion per year globally, will rise by more than 60% in the next five years, it concludes.
Addressing data centre energy demand
Recognising the burgeoning energy demand represented by their services, major players in the data centre sector have established their environmental credibility by securing renewable energy supplies or upgrading energy supply and cooling systems to improve system efficiency.
For instance, new research from Emerson Network Power found that around half of all data centre cooling systems in North America will be upgraded before the end of 2016 for improved reliability and efficiency.
In a survey of IT, facilities and data centre managers, Emerson reveals that 40% of data centres have been upgraded in the past five years, nearly 20% are in the process of being improved and about 31% will be upgraded in the next 12 months.
"Reliable performance and efficiency have always been critical to large data centre performance," said John Peter Valiulis, vice president of thermal management marketing for Emerson Network Power in North America. "As edge and cloud computing become ubiquitous, ensuring the health of cooling systems at smaller, localised data centres and computer rooms is crucial. Thermal upgrades are allowing companies to improve protection, efficiency and visibility within all these spaces."
Standards have a key role to play in cooling system performance. For example, IEC 60335-2-40:2016 deals with the safety of electric heat pumps, including air-conditioners, and of dehumidifiers incorporating motor-compressors. It also applies to electric heat pumps, air conditioners and dehumidifiers containing flammable refrigerant. Similarly, IEC subcommittee (SC) 61D considers appliances for air-conditioning for household and similar purposes. It has the scope to prepare international safety standards dealing with electrical equipment used in commercial or light industrial applications, primarily for the purpose of conditioning air.
The Emerson survey also revealed that 40% of data centres were also said to be adding economisers to provide 'free cooling' when outside temperatures allow.
Location, location
In a bid to reduce cooling loads, some major players have relocated to regions with typically lower ambient temperatures, such as Nordic countries. For example, Google has a data centre located in Hamina, Finland, which uses sea water from the Bay of Finland in its heat exchangers to reduce energy use from the server cooling load.
Taking this concept a step further, Microsoft recently concluded a trial programme of a data centre deployed under the sea. Project Natick seeks to understand the benefits of and difficulties in deploying subsea data centres worldwide. After a series of tests, the Leona Philpot server was lifted out of the water late last year for assessment. Power to the server was supplied by submarine power cables.
Although IEC International Standards do not specifically cover submarine power cables, major submarine power cable manufacturers like ABB or Nexans rely heavily on IEC International Standards when manufacturing high quality products. Mentions such as "the continuous current ratings are calculated according to IEC 60287 series of Standards" (ABB XLPE Submarine Cable Systems), or "Maximum value to IEC 60228" and "Calculated in accordance to IEC publication 60287" (Nexans Submarine Power Cables) are present throughout their marketing literature as evidence of compliance with internationally-recognized Standards.
Achieving more
Even with such high profile developments, Ory Zik, VP of Analytics at Lux Research, argues that much more could be achieved with coherent analysis. He explains that, despite their sophistication, leading IT and computing giants in the US use crude and outdated information to calculate the carbon footprint of their data centres. He claims this leads to a shortfall of roughly 25% in emissions reporting.
"Data centres comprise the fastest-growing energy buying sector and the companies that run them have the most advanced data analytics tools at their disposal, as well as high-minded public commitments to sustainability. They should lead rather than lag, by using more accurate data to report on their emissions – and to inform the actions they take to reduce them", he says.
However, Zik believes that consumers will demand better transparency and traceability from companies. "I think that as we move forward, with more data devoted to understanding our environmental impact, consumers will have this coherent picture and once they have it, they will demand greener products like data from an environment perspective. This will force companies to improve their performance, because otherwise they will be losing customers."
He emphasizes the key role that emerging standards will play in benchmarking environmental performance: "We need to look at this more holistically and just apply data and calculate it [environmental impact] properly. I definitely see standards playing a key role".
This is a point noted by NRDC, too. It concludes that "to move forward, systemic measures such as the public disclosure of efficiency metrics are necessary to create the conditions for best-practice efficiency behaviours across the data centre industry".
One measure that may support this goal is ISO/IEC 19395:2015, an International Standard for smart data centre resource monitoring and control, which was prepared by ISO/IEC JTC 1 SC 39: Sustainability for and by Information Technology. ISO/IEC JTC 1 is the Joint Technical Committee set up by the International Organization for Standardization (ISO) and the IEC to develop International Standards for Information Technology.
Changing standards
Jack Pouchet, Vice President of Business Development and Energy Initiatives, Hyperscale Solutions, at Emerson Network Power, argues that improved standards are a key route to greater energy efficiency. He cites 80 Plus, a voluntary certification scheme designed to promote efficiency in computer power supply units and launched in 2004 by Ecos Consulting. It certifies products that have an energy efficiency of more than 80%. Pouchet sets out a call for a similar standard focused on idling energy use, which he couches as '10 Minus'. "They're starting to focus on driving down the idle energy demand, but there is really no industry-wide push that these things should consume less than 10%, or less than 5%, or less than 1% [at idle]. There are no goals, there are no targets", he told e-tech.
Pouchet calls for a data centre equivalent of an X-prize for a production server that uses less than 10% of energy at idle.
As standards evolve to reflect more accurately the reality of data centres, other avenues to energy efficiency are emerging too.
For example, ASHRAE, the American Society of Heating and Refrigeration and Air-Conditioning Engineers, has produced updated standards for temperatures and humidity for computing equipment in data centres.
Says Alger: "Over time they have gradually broadened what they consider to be acceptable ranges. As those ranges expand, this opens up more flexibility. You can start to bring in outside air cooling, which is one of the ways in which people are being more efficient. The more comfortable you are running your equipment warmer or cooler within these different ranges, the greater is the number of days that outside air can work for you and you can let mother nature cool your system for you, rather than having to run the condensers in your air conditioning system".
Alger adds: "I certainly think standards can play a key role in the behaviours that they can encourage for people as they are designing and operating data centres".


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7 Ways to Keep Pests Out of Your Home
Everyone wants to live in beautiful Charleston, South Carolina – not just people, but rodents, ants, termites, palmetto bugs, bees, wasps, and mosquitoes, too! At one point or another, every home in the Lowcountry will suffer from pests. Once they're in the house, you can try getting rid of them yourself or you can contact… Read more »


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It was Family Day weekend and I was working hard to get the kids out the door and over to my parents' house where both of my sisters and my little niece and nephew were visiting. My sister had kindly popped by to help me wrangle the troops. All 3 kids were practically body surfing … Continue reading Not on my Watch: I've got 99 Problems but Explaining 'Squirrel Death' Ain't One
Overcoming Social Obstacles: Shimmering & Shining my Little Girl's Social Life
It was bedtime in our house. We had just finished family story time in 5 year old Miss M's room. I was across the hall, laying with sleep-resisting, 2 year old, Mr. O while Hubby read one more book to our big kids; Miss M and 4 year old, Mr. C. Mr. O was almost … Continue reading Overcoming Social Obstacles: Shimmering & Shining my Little Girl's Social Life
Managing Big Emotions: Learning to Control our Inner "Fire Power" Because in a World of Marios, Somebody's Got to Be Luigi
I was enjoying 45 seconds alone in the bathroom with the door locked (Ha! I'm getting smarter!) when I heard blood-curdling screams and hysterical cries from the family room. They weren't the cries that indicate a bumped head, a stubbed toe, decapitation or a severed limb... these cries meant something far worse... someone wasn't getting … Continue reading Managing Big Emotions: Learning to Control our Inner "Fire Power" Because in a World of Marios, Somebody's Got to Be Luigi
Love, Food, Photos…Enough is as Good as a Feast
It was a typical Thursday afternoon in February except that was feeling more stressed than usual, worrying about things that didn't need to be worried about and I was just feeling low. I had just picked the kids up from school and we were now at Nana's house to pick up Mr. O. It was … Continue reading Love, Food, Photos…Enough is as Good as a Feast
The Dreaded Mammo Callback
Two days after surviving my very first mammogram, I received a call back from the mammography clinic. The friendly receptionist informed me that the radiologist has requested that I come back for additional imaging. My heart sank. Okay... I replied and then requested the next available appointment that they had. "I will put you in … Continue reading The Dreaded Mammo Callback
The SQUEEZE on Mammograms… See what I did there?!
My very first mammogram...and what to expect when you go for yours!
My Kinders on Ash Wednesday…
My 5 year old, Miss M and 4 year old, Mr. C got to attend Ash Wednesday mass at church with their school today. Here is their story... Me: Did you guys get to go to church today? M&C: Yes!!! M: They put ashes on our heads just like you said! C: But mine came … Continue reading My Kinders on Ash Wednesday…


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You're only seeing part of the forum conversation. To see more, register for an account. This will give you read-only access to nearly all the forums.
Oh wow, it's only 6 days after my 21st birthday!So not only will I actually be able to go, I'll be able to drink a lot! This could genuinely be the best experience of my life!Wrought, July 14, 2018, 10:53:51 pm
Don't try to drink a lot within a week of your 21st birthday. It'll hurt. I speak from experience.Sherman has The Penis to satisfy The Tank!, July 14, 2018, 11:43:09 pm


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"The sovereignty you have over your work will inspire far more people than the actual content ever will." - Gaping Void
Thursday, September 27, 2007
1 comment:
- John Powers said...
"We sincerely hope you'll join our growing community..." So says Negroponte. I suspect he really is sincere, but the word "community" always makes my head spin when it's used to refer to diverse and geographically dispersed people. It's the ready metaphor for the peerosphere, yet doesn't quite fit.
This buy one give one idea has great potential, but something seems strange about the approach; it seems they're missing something about how the peerospheric "community" really is.
Beth's Blog raises the issue about whether or (probably) not being able to designate recipients. Without the ability to do so it makes dispersed fund raising unlikely.
I can't remember where, but someone else was talking about how the exciting part of getting a quantity of OLPC in the hands of people in the developing world was the creation of curriculum materials specifically designed for them.
So much of the design of the OLPC is all about enabling networked cooperation. Perhaps the focus on getting governments to commit has blinded Negroponte to the ways that networked cooperation--different from governments--can empower this effort.


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What an absolute blast to meet a woman who I have admired from afar for so long.
Daphne Guiness – style guru supremo – is in Australia to launch the exhibition of her friend, the late Isabella Blow at the Museum of Applied Arts & Sciences.
I always remember seeing the beautifully eccentric Isabella Blow at the fashion shows is London, Paris, Milan and was constantly knocked out by her innate, sensational style.
Daphne purchased the entire fashion collection belonging to Isabella, as she was very close friend. And has since set up a charitable foundation in her memory. Unfortunately, we lost Isabella to suicide much too early.
Anyone can take a look at the exhibition at the MAAS in Ultimo, Sydney.
Loved the fact Daphne wore some very cool Romance Was Born to the after party, held at the acclaimed Sherman Gallery in Paddington.
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Isabella Blow: A Fashionable Life provides a rare chance to see garments, hats and shoes by iconic British designers such as McQueen and Treacy in addition to the designs of Manolo Blahnik, John Galliano, Jeremy Scott and Viktor & Rolf. The bespoke exhibition features approximately 100 objects from Isabella Blow's collection and will be on display to 28 August 2016.
Isabella Blow nurtured the careers of many designers, photographers and models from the 1980s until her tragic death in 2007. The muse of milliner Philip Treacy, she is credited with discovering the models Stella Tennant and Sophie Dahl as well as the fashion designer Alexander McQueen. Her editorial work, the images she created and her personal collection of clothes, photographs and illustrations leave behind a legacy of one of fashion's most talented mavericks.
In 2010, fashion muse, patron and artist, The Honourable Daphne Guinness purchased Isabella's wardrobe and established the Isabella Blow Foundation. Guinness will visit Australia to open the exhibition and appear at a number of public events at the Powerhouse Museum and Westfield Sydney.
Deputy Premier and Minister for the Arts, Troy Grant said the Powerhouse continues to attract world- class exhibitions that will draw visitors from across the state and internationally.
"Isabella Blow: A Fashionable Life takes visitors on a journey of twentieth century British fashion through the lens of a fashion editor. Blow's influence on local Australian and global trends is both immediately evident and fascinating," Mr Grant said.
"With Collette Dinnigan: Unlaced also on show until the end of August, there is the chance for visitors to get a double dose of fashion at the Powerhouse this winter," Mr Grant said.
Minister for Trade, Tourism and Major Events, Stuart Ayres said this exhibition continued to build Sydney's reputation as the Australian home of fashion.
"This winter, visitors to Sydney have the opportunity to get a close up look at famous works by seminal British designers. With this exhibition exclusive to Sydney, this is the only place in Australia to see original, early works by designers who are now household names."
"Against the backdrop of Wool Week, Vivid Sydney and Mercedes-Benz Fashion Week Australia, this exhibition provides yet another reason to head to Sydney this May," Mr Ayres said.
Museum of Applied Arts and Sciences (MAAS) Director, Dolla Merrillees, said the exhibition continued the work of the MAAS Centre for Fashion.
"Through the MAAS Centre for Fashion we offer unique ways to explore the world of fashion, whether through the collections of fashion icons as with the Centre's inaugural exhibition Collette Dinnigan: Unlaced, or by hearing first hand from esteemed fashion critics like Suzy Menkes."
The exhibition will be accompanied by a series of public programs, including a week-long pop up at Westfield Sydney, which will feature intimate talks from Australia's leading designers, and an event with Daphne Guinness in conversation with Harper's Bazaar editor Kellie Hush at the Powerhouse Museum on 12 May.