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WD released its 7th make of its My Passport Ultra series external HDD with USB 3.0 interface. There are two storage space variants (1TB and 2TB) with four colour variants- Classic Black, Brilliant White, Wild Berry and Noble Blue. It ...Read More »
WD My Passport Slim 1TB USB 3.0 WDBGMT0010BAL Drive Review
When the concept of having 2.5" drives started, in countries like India a lot of buyers used to buy a casing and an internal 2.5" drive. Back then, a lot of people used to ask the question "Are company labelled ...Read More »
WD My Passport Ultra 1TB WDBZFP0010BBK-01 USB 3.0 Drive Review
WD introduced My Passport Ultra with a 500 GB Variant- and a review of that drive was put up the last time. This time, we'll be checking out the 1TB counterpart of the My Passport Ultra drive.Read More »
Toshiba Canvio Desk USB 3.0 drives now available
Rashi Peripherals sent a press release about Toshiba Canvio Desk USB 3.0 now being available in India with the warranty period of 3 years. The Canvio Desktop comes with their backup software called NTI Backup Now EZ. Toshiba mentioned that its ...Read More »
WD My Passport Essential 500GB USB 3.0 HDD Review
I've reviewed series of hard drives with USB 3.0 implementation and so it is going pretty nicely. WD India sends a couple of drives for evaluation. There you go! WD My Passport Essential 500gig USB 3.0 drive… With the motherboard ...Read More »
Seagate GoFlex 1.5TB Ultra Portable HDD Review
This is the review of the Seagate GoFlex 1.5TB USB 3.0 (STAA1500301) Ultra Portable External Storage drive review. The goodness of the USB 3.0, 3 years warranty, Seagate Dashboard software and powering up the storage brick from a single Connector: ...Read More »
Seagate GoFlex Slim 320GB USB 3.0 HDD Review
..And so "they" say: Slim is in! Seagate India sent a GoFlex Slim drive for evaluation. They had a press launch few weeks ago so you can check up on that. 9mm Thickness (7mm is the thickness of the drive) ...Read More »
Western Digital MyBook 3.0 USB 3.0 1TB External Storage Drive
USB 3.0 devices have started coming in and Western Digital sends one for evaluation to make a good impression. As you can see on the picture itself, Western Digital bundles a USB 3.0 PCIE X1 card powering up 2 ports. ...Read More »
Seagate introduces GoFlex for MAC external drives
New Collection of FreeAgent® GoFlex™ for Mac External Drives Are Designed for Mac Enthusiasts While Maintaining Cross-Platform Compatibility.Read More »
Seagate Freeagent GO 80GB External Drive
Now, for some of us, we need portability, and hence man made laptop. But for most of us, a memory which carried as much as what a hard drive can hold and want to make it as easy as plug ...Read More »


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Window Screen Company Tualatin Oregon
Kraft Screens services customers in Tualatin. We are a full service screening and shading company, providing window and door screens, pet products, and more. Kraft is a family business, started in 1995, and a local leader in both residential and commercial screening and shading systems. Our customers always come first and our expert installers bring you professional on-site service. We use only the best products, many under a lifetime guarantee.

subset: commoncrawl


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The historic Abbey Road Studios are set for a multi-million pound renovation, in order to bring in more pop stars and also help with the creation of film scores.
The recording studios in North West London will have brand new, state-of-the-art equipment installed, reports The Telegraph. This will include a Dolby Atmos system, a surround sound system set to be used in the making of film soundtracks. "It uses up to 128 audio tracks and up to 64 speakers to create the illusion that sound effects and music are coming from specific points in the room," writes the newspaper.
The work will be completed next year, but will require planning permission, as the studio is Grade II listed. The new plans were approved last week by the British chief executive of Universal Music, Lucian Grainge. Universal took over Abbey Road Studios when it bought previous owners EMI in 2012.
In November 2014 unused photos from The Beatles' 'Abbey Road' photoshoot sold at auction for £180,000. The shots were taken on August 8, 1969 by photographer Iain Macmillan, who had only 10 minutes to complete the entire shoot. Six photos were taken in all, including the photo that eventually made the final cut, as well as a scenery shot of the Abbey Road sign.
"This set of photographs has triggered a brilliant reaction from the market," said Sarah Wheeler of Bloomsbury Auctions. "It has been a pleasure to share them with the public at our sale rooms, even for a short time, and a delight to see them attain such a worthy price today."
The sale was made over the phone to an overseas buyer. The collection was originally given a sales estimate of between £50,000–£70,000.
'Abbey Road' was released in September 1969, with the iconic album cover beloved and parodied ever since. The artwork is also the focus of several conspiracy theories, including one that Paul McCartney is in fact dead and was replaced on the sleeve by an imposter.


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Interested to know what is the best electric broom for pet hair?
When I was young, I always wanted to live alone in a house with no kids or any other person except myself. But as time passed by, I decided that somewhere within me I also wanted to have companions in life- and that was when I developed a liking to pets. So I started to adopt one dog and was followed with more pets and currently I live happily with my two dogs and one Himalayan kitten. Actually, not all the time(happy) because every morning I wake up with countless poops and pees all around the house.
I have read about the electric broom which was really the perfect thing for me and my pets. Well, obviously I currently don't have it so I thought to do more research if this was really the answer to my question- and yes I was not mistaken! I have read a lot about the electric broom for pets that can clean all the mess they leave.
What is great about this electric broom is that it totally works like a vacuum which can clean almost everything our pets leave behind: poo, pee, and even their shedding hair. You may think that you don't need this because you have your old vacuum at home and it will make no difference since they work the same- well, you are wrong. Electric broom indeed works like a vacuum but it exceeds in other aspects. Firstly, it is very handy- you can simply use one hand to use it unlike other big vacuums wherein it requires a lot of sweat just to get the work done. Secondly, it is small- which is very important for storage. You don't have to allocate a lot of space for this. In addition to the size, the electric broom is also lightweight- meaning you don't have to bother yourself to do a lot of effort in transferring the cleaning appliance. Another factor is that electric broom is battery operated. Others won't like this but a lot of people admires this feature. Others think that they will spend more since you have to buy some batteries just to make it work but there are a lot of rechargeable batteries around and this also saves you the effort of bringing the long cord all around your house.


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After missing out on our listing last month at 80-12711 64 Ave, our buyers knew they wanted something very similar and we found it in this West Newton Townhouse. We ended up viewing several townhouses throughout Surrey but nothing really compared, until we found this unit. We scheduled a viewing and our buyers knew they wanted this West Newton Townhouse from the minute we walked through the door. Unfortunately another buyer already had an accepted offer on the townhouse, however the offer ended up collapsing, and we jumped on it.
Spreading over 1,500 square feet and three stories, this West Newton Townhouse features three bedrooms, three bathrooms, a double tandem garage, and backs on to a beautiful greenbelt. Being a corner unit, this West Newton Townhouse offers a lot of privacy and is situated in a family-oriented community, next to Tamanawis High School and Khalsa Elementary School. This West Newton Townhouse is centrally located, allows easy access to Highway 10 and 64th Avenue, and has many amenities close by.
The area of Newton is home to several attractive parks, from scenic trails around Surrey Lake, to the shoreline views and bird watching at Mud Bay Park, as well as the athletic facilities at Newton Athletic Park, there's something for everyone. West Newton Community Park features a regulation sized cricket field and Panorama Park is home to a large off-leash dog park.
Interested in finding out what you townhouse is worth in this hot market, or, looking to land something similar? Contact us today!


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Marathons are long distance races, usually held on rivers & canals.
Races are divisional and promotion is gained when the paddler is as quick as those in the division above. Paddlers start in Div9 racing 4miles (at Div6 race 8miles, at Div3 12miles).
Most races form part of the "Hasler Series" where points are awarded to individuals per race, 20 for 1st, 19 for 2nd, and so on. The individual points are tallied and points awarded to the club for their overall position at that race meeting, 10 for 1st, 9 for 2nd, and so on. These club points are accumulated through the season and the highest ranked clubs per region compete at the national finals, usually held in October, where you will have a chance to race against the best paddlers in the country.
As well as the Hasler races there are other regular challenges throughout the year, with races of varying lengths from 5miles to 125miles. For example, Pennine CC regularly takes part in The Conwy Ascent (a 10mile upstream paddle which can be entered as a race or just a picturesque tour) and are looking to take as many members as possible in 2013. Also in the past, club members have competed in the Devizes-Westminster (125miles over the Easter weekend) and the Cheshire Ring (90miles around Manchester) as well as many others.


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Jean Baptiste LePage was a French-Canadian fur trader who was living among the Hidatsa and Mandan Indians (near present Bismarck, North Dakota) when the explorers arrived there, October 27, 1804. Lewis, by his January 15, 1807 letter to the Secretary of War, Henry Dearborn, transmitted a Roll of the men who accompanyed Captains Lewis and Clark on their late tour to the Pacific Ocean...with some remarks on their rispective merits and services. Here, LePage is rated as Entitled to no peculiar merit. Was enlisted at Fort Mandan, on the 2d of November 1804 in order to supply the deficiency in my permanent party occasioned b the discharge of John Newman. He performed the tour to the Pacific Ocean and returned to St. Louis, where he was discharged in common with others, on the 10th of November last. As he did not perform the labors incident to the summer of 1804, it would be proper to give him the gratuity only of two-thirds as much as is given to others of his rank.
See also The Lesser-Known Members of the Corps.
Contents || Inside The Corps | The Corps || Site Map | Send Feedback


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Everyone has heard of the saying that the kitchen is the heart of the home. In our family that couldn't be more true and you will find out just why with our #kitchentale...
I finally had space to actually cook! We also got a dishwasher for the first time and whenever we have guests to dinner, I whisper a thank you to my dishwasher as I wonder how I managed so long without one.
Our new kitchen also opened up the doors to a whole lot more...
It was big enough for J to do his Occupational Therapy excercises in.
It was big enough to have teddy bear picnics on the floor.
It enabled us to start home-schooling J and D as there was space for a table for them to work at (we even managed to fit in individual desks for them on the other side of the kitchen too!)
It meant that when Miss T was born, I was able to keep an eye on her whilst being in the kitchen (there was no way a highchair could have fitted in our old kitchen).
It faces the garden so I can keep an eye on these three even when I am indoors and they are outside.
And it truly has become the place where we can all 'hang-out' - the kids can sit at the dining table which now fits in our kitchen, and play board games or school work or just chat with me whilst I am doing chores or cooking.
And we even decided to keep hold of our old dining table which was dented and stained but makes a perfect art and craft table.
Our new kitchen meant that I could finally have a decent sized fridge rather than the teeny under-the-counter one I had before which saves oodles of time not having to pop to the shop to buy milk daily because more than a couple of pints each day just wouldn't fit in the old fridge.
Of course the fridge has to have the alphabet fridge magnets which seem to be oligatory once you have kids in the house. And it doubles up as a bit of an art gallery too.
One of my favourite things I keep on my fridge is a letter from J after he / we had a difficult day.
Although I often have plenty of helpers on hand to help with the mixing anyway as it is Miss T's favourite job in the kitchen.
his blog, The Brilliant Chef, and even make recipe videos of him. None of which could have been done in the old kitchen as it really was too small to even take photos.
We have a few little touches that make out kitchen our own like growing a few herbs on the windowsill.
We weren't quick enough to get a sample of Fairy Platinum Dishwasher tablets but bought our own to try as we love and trust the Fairy brand so much already. Whilst I have Fairy to help with the dishes, I have another little helper to help me clean the floors by tying rags to his feet and sliding around the kitchen.
I hope you can see just how important our kitchen is to us and why it has truly become the heart of our home.
"This post is an entry for the "My Kitchen Story" Linky Challenge, sponsored by Fairy Platinum" . You can find Fairy on facebook at Facebook.com/fairydish. And you can find out more about #Kitchentales over on Britmums here.


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I started making my four year old a sweater yesterday, discovered there was a problem with the sizing of the pattern (thankfully I discovered that pretty early. The pattern said it was for a child size 6, but it was actually a toddler size 6) I froged it, found a different pattern (hopefuly simple enough for me to understand) and started over.
I've never made a sweater before, so this is totally new territory for me. Hopefully I won't screw it up, or at least not so bad that he can't wear it.
It cracks me up that the kids like it so much when I make things for them. (it makes me feel good to )
I'll post pictures of my progress.


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The other day, I was discussing the environment with a liberal friend of mine when he said all the actions we were talking about, restoring rangelands, saving endangered species, an that srot of thing were better than doing nothing, but what we really need to do to solve most, if not all, of the problems with the environment is for about half of the people on this planet to disappear. Actually (after acknowledging that what he was going to say wasn't "politically correct") he said was that what needed to happen is that about half of the people on earth should be killed in a nuclear war or a plague or something. The reason he said that, of course, is that he, like all liberals (and many conservatives), believes that the real cause of environmental problems is that there are too many people.
As happens frequently in situations that make me uncomfortable, I couldn't think of a clever and appropriately devastating rejoinder to make on the spot, so I just grunted and acted disinterested and hoped he would change the subject.
Later on it occurred to me that I should have called him on what was a totally cruel, tasteless, stupid, and completely empty comment—I'm pretty sure he wouldn't want to be responsible (by wishing it) for the death of a couple of billion people, but when it comes to liberals, I'm not so sure anymore.
A good retort to his comment, it occurred to me, would have been to say, "Knowing how you feel about peace and love and all that I'm sure you would never condemn anyone else to be nuked or plagued or committ suicide, or even ask them to do it in your stead. So, I assume what you just said means you, and the other people who think like you, are volunteering to remove yourselves from the planet in order to save it from overpopulation. That is so courageous and self sacrificing, I'm totally in awe. When do you plan for this to happen, and is there anything you'd like me to do for you after you're gone?"
While I was kicking myself for not having said the above, another thought came to mind that was much more of an awakening and absolutely chilling. It occurred to me that liberals really are removing themselves from the earth, and that they really are committing mass suicide, and they are doing it at a really startling rate. Shades of Hale-Bopp and Jonestown!
At that point I remembered a couple of environmentalists I knew, and a couple more I'm aware of, who killed themselves because they thought they were "part of the problem." I thought of a woman in England whom I had heard had herself sterilized so she couldn't increase her carbon footprint by producing other humans. I thought of myself and my wife who had essentially done the same thing—We didn't have kids at least partially because we swallowed the "Earth is overpopulated" propaganda, too.
I also thought of an article by Mark Steyn called "It's the Demography, Stupid"). In this article Steyn pointed out that in the U. S. there are only 2.07 births per woman. In Ireland 1.87. In New Zealand 1.79, Australia 1.76, and in Canada 1.5, which is well below replacement rate. Germany and Austria come in at 1.3. Russia and Italy at 1.2; and Spain is at 1.1, which is only about half replacement rate. This means, Steyn points out, that "Spain's population is halving every generation. By 2050, Italy's population will have fallen by 22%, Bulgaria's by 36%, Estonia's by 52%."
In America, demographic trends suggest that the majority of this attrition by far is happening among liberals. Steyn notes that, "In the 2004 election, John Kerry won the 16 states with the lowest birthrates; George W. Bush took 25 of the 26 states with the highest." By 2050, the 100 million more Americans who will be alive will be mostly red-staters.
The next time you talk to a liberal tell him or her goodbye, thank them for their sacrifice, and ask them if you can have their Prius or, better yet, their wine collection.
Ed Abbey, guru of modern radical environmentalism, promised his followers that they would live to "piss on the graves of their enemies." It appears that he may have had it backwards.
But before you start thinking that liberalism and liberal environmentalism contain the seeds of their own suicide, you should consider the fact that this movement is a very, very good recruiter.
That is the real issue here, and it is the subject of the next and most important post of this blog yet.


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ABDL Stories - Browse Stories from A to Z
Search Our Archive of Diaper Stories & Abdl Stories sorted for ease.
» » Marys Memorial Day Weekend Part 13 « «
Chapter 13
David's Story Continued
I awoke before Mary on Monday and I decided to let her sleep a little longer. I knew that today would be a test of her willingness to be a diaperslave and so I unlocked her wrists and ankles from the bed posts while she slept, leaving the cuffs on her wrists and ankles just to remind her of the diaperslave that she was. As I gazed on her lithe form, she turned onto her side and pulled her knees up to her chest in the fetal position. She looked so cute sleeping there with no bed covers on and just wearing her diapers and plastic panties. I could tell that she was very wet, wetter than the way I had left her the night before.
I went to the kitchen and began to fix breakfast. I fixed a huge bowl of oatmeal for Mary, knowing that it would provide bulk to fill her diapers, and also coffee and orange juice laced with Metamucil. When her breakfast was ready I returned to the bedroom and found her lying on the bed looking confused and scared. As soon as I came into the room she began to apologize and to cry that she hadn't unlocked her hands and feet and for me to please not be mad at her, that it wasn't her fault. I assured her that I had released her and that I did so because I wanted to test her willingness to obey me without the necessity of my keeping her in bondage. But I told her that could change at any moment should she disobey me. She smiled shyly and told me she wanted to obey me and would try her best to do so.
She got up and followed me into the kitchen, her sopping wet diapers drooping down between her legs. After all, they contained my pee and Mary's pee and pussy juices from our activities last night as well as her overnight wettings. Once in the kitchen she saw the bowl of oatmeal waiting for her and was smart enough to realize what that meant. I told her to finish it all and that I would not change her diapers until she had done so. I reminded her that the weekend was far from over and that I expected absolute obedience and acceptance of whatever I chose to do with her.
After she had finished her breakfast we sat at the table while she finished her orange juice and had several cups of coffee. I had Mary come over and sit on my knee and she did so facing me. I am sure she could feel the bulk of her diapers being pushed against her love spot. She seemed to rock back and forth more than necessary. I was also sure by the way she rubbed her leg against my crotch that she could feel my maleness getting bigger and harder. She really was turning me on. I held her close and massaged her little titties until her nipples were standing upright and hard. We talked a lot about her feelings and about her mixed emotions at being made to wear and use her diapers. She said she was embarrassed and humiliated at the juvenile clothing, but at the same time experienced both a great feeling of comfort and security in her diapers and a strangely exciting turn-on when she had to wet or mess her diapers or when she knew that others were seeing her wearing diapers and plastic panties.
She thanked me profusely for taking the time to train her and teach her the pleasures to be obtained from becoming a diapergirl. She also apologized for all the times she had caused me trouble and had disobeyed me. She vowed that I would never have to punish her again, a vow I knew she couldn't keep.
As she sat there on my lap I could hear and feel her wetting her diapers again. I decided to let her sit in her wet diapers for a while as we continued our talk. I could feel her moving her butt around, trying to get satisfaction while she massaged my crotch with her leg, trying to get me even harder than I already was. I told her she was a horny little diaperslut who couldn't think of anything but sex! She blushed prettily, but didn't stop her maneuvering.
After we had finished our little chat, I led her to the bedroom and lifted her up onto the changing table. Not bothering to secure her wrists or ankles I had her flex her knees and lift her bottom up so I could remove her plastic panties. The odor was really strong and I used some air freshener to clear the air. I unpinned her diapers and brought them down from between her legs. She was very wet and I decided that she needed a bath. I helped her off the table and brought her into the bathroom with me while I ran her bath. I could see her looking longingly at the toilet, knowing that it was off limits for her. She stood there, naked, while I drew her bath and then got into it when she was invited to do so.
I bent over the tub and cleaned every inch of her skin, paying particular attention to her titties and diaper area, making sure that every crevice in that area was completely cleaned up. She began to moan and breathe hard as I ran my soapy hand up and down her pussy and into her rear opening, just to make sure she was thoroughly cleaned. While she was in the bath, I took the opportunity to shave her, to make sure her pussy was as bare as a newborn baby's. She did not object or even flinch when I brought the razor down to her pussy lips and began to run it over her skin. She even spread her legs wider to give me better access. She gave me to believe that she accepted this as my right, that I had control over her body and could do with it as I willed. I really regretted the idea of returning her to Ron that night, and began to think about ways to retain possession of my little Mary.
I told her that she still had a few things to learn in order to become a proper diaperslave. And that she would learn them before we returned to the city this evening. At all costs she must never refuse a command, or even a desire, of her master or mistress. She reacted with a startled expression when I mentioned the word "mistress" and I explained that at times her master might want to lend her to a mistress or find it necessary to provide her with a "sitter" while he attended to other affairs and that if he did so, she must respond to that mistress as she would to her master.
She apologized for her initial reaction and thanked me for reminding her that she must do whatever her master or his designated substitute told her to do, no matter how she felt about it. I told her that today we would test that resolve.
I finished her bath and dried her off, again paying special attention to every nook and cranny of her diaper area, running the soft terry cloth towel through her pussy slit so it touched every nerve ending in that part of her body. She responded by moving her hips back and forth, as if to help me, and began that hard breathing which gave away her level of excitement. When she started to get really excited, I stopped and told her that she would come to climax soon enough, but not now. That she must learn to understand and accept that only her master would determine when and whether she would be allowed to have an orgasm. She barely concealed her disappointment as she thanked me for the bath and for taking the time to make sure she was clean and dry. She stood there in the bathroom, naked, waiting to learn what was to come next.
Knowing that if I left her undiapered for even a short period of time she would begin to leak, I led her, still naked, into the living room. I spread a plastic sheet on the floor and told her to sit on it, cross-legged. I told her the sheet was only a precaution should she disobey me and I forbade her to wet the sheet. I also forbade her to touch her body in any way. She sat there with her perky little nipples erect in the middle of her little mounds of tits (more like a molehill than a mountain) and her cunt lips spread out and swollen for all to see between her parted legs. Her hands were resting at her sides as she dared not touch any part of her body. She did not want to experience any more punishment, although I had set her up so she could not obey me. I knew she would soon start to leak on that plastic sheet and I would have to punish her.
As she sat there on the plastic sheet, naked and cross-legged, her pouting pussy staring out from between her legs, and very vulnerable, I continued to lecture her on her responsibilities as a proper diaperslave. I reminded her that I had gone to considerable trouble and set aside my entire holiday weekend to help train her to be a good diaperslave and that she should be eternally grateful to me for my efforts. I told her that there were any number of other things I could have been doing this weekend that would be a hell of a lot more fun than changing her wet and messy diapers, and that I intended to make some changes that would make caring for her both easier and more rewarding for me.
As Mary listened bugged-eyed, I explained that, no matter what she did in her diapers, they would only be changed four times a day: after breakfast, after lunch, at cocktail time, and just before bed. Furthermore, since I was going out of my way to change her and to endure her stinky diapers, I expected "compensation" from her for changing her each time. And since change time would be the only time she would ordinarily be out of diapers, I would take the opportunity to require her to satisfy me sexually at each diaper change. I asked Mary if she agreed and she surprised me by grinning and instantly agreeing to the fairness of what I had said. Her alacrity in responding confirmed to me that I was on the right track and that Mary, indeed, would become a proper diaperslave.
I pointed out to her that even as we had talked about the need for obedience and her responsibilities as a diaperslave, she had been disobeying me. I had told her that she was not to wet the plastic sheet and she had done so, and I pointed to the puddle that was growing between her legs and under her bottom. She had been focusing her eyes on me as we had been talking, but now she looked down and a look of astonishment came across her face as she realized that she had, in fact, wet the plastic sheet, and not just a little, it was a real puddle.
I reminded her, "You promised to obey me, but you are obviously incapable of controlling your wetting. If you had thought you were incapable of doing so you would have told me so and not have promised not to wet the plastic sheet. Am I right? You did wet the plastic sheet, didn't you? That's not just sweat, is it?" She embarrassingly had to admit the evidence of her own eyes, that indeed she had wet on the plastic sheet, apparently without even noticing she was doing so. I told her that she would have to be punished for her disobedience and also that she would now have to admit that she could not control her own bladder and that she *belonged* in diapers. She nodded her head in embarrassment and could not look me in the eyes. That was not good enough. I told her I wanted her to look at me and to respond properly, verbally. She looked up at me with tears in her eyes and choked out the words, "Yes, master, I am incapable of controlling my bladder." She remembered our conversation from last night and blushed red all over. She looked up at me as the realization came over her that she really did *belong* in diapers and what that meant. As she looked into my eyes she repeated the words she remembered from last night: "Yes, master, I am a wet and messy diaperslave who belongs in diapers. It is a privilege for me to be diapered, and I *want* to be diapered anytime you have no other use for my pussy or my... (She almost choked on the words.) my asshole."
I told her that now that she had acknowledged her dependence on diapers, I expected her to ask to be put back into diapers anytime I took her diapers off, and that any time I chose to leave her without diapers, I expected her to ask me to place a waterproof pad under her. She nodded and I again reminded her that was not good enough, that she must respond verbally and appropriately, and that added punishment would be given her for her failure to do so. She looked so humble as she said, "I will ask to be put back into diapers anytime you take my diapers off and I will ask that a waterproof pad be put under me anytime you wish to leave my diapers off." Now that she admitted her lack of control, I forbade her from ever even trying to use a toilet for any purpose whatever and the only acceptable verb for her to use to refer to her own urination was the verb "to wet", because the verb "to pee" implied volition which she clearly lacked. She gasped in amazement, and blushed all over, but she managed to stammer, "Y..yes, Master, I am only c..capable of wetting myself, and I will n...never try to use the toilet."
That business being satisfactorily taken care of, I led her back into the bedroom. I had her assume a position on all fours on the bed, but with her knees at the very bottom of the bed. I made a great show of placing a waterproof changing pad and an extra-heavyweight pre-fold diaper between her knees, which, of course, maked her knees apart. I told her that she would wear that diaper no matter what she did on it. I examined her rear and told her that her asshole needed training to become more easily penetrable, and that I intended to institute a program to insure that. I showed her a double dildo, one with two parallel eight inch prongs, each an inch and a half thick and shaped like a man's prick, which would violate both her asshole and her pussy and told her that soon she would experience that instrument, but that first she would need some preparation, that I would have to open her ass up some more. I placed the double dildo on the bed in front of her where she could continually look at it. She moaned and begged for forgiveness, but there was also a look of excited anticipation in her eyes. I told her that more pleading would only add to her punishment, that she should be thankful that I was taking the time to train her. She stopped her pleading and thanked me for training her to be a good diaperslave and said that she knew everything I was doing was for her own good.
I reached between her legs and began to play with her pussy, running my hand up and down her slit and massaging her clit with my finger. She started to move her rear up and down and around in response to what was being done to her.
Her position at the foot of the bed made her rear end very vulnerable as I stepped between her legs and spread K-Y jelly all around her asshole and even invaded that orifice with my lubricated fingers. When she was sufficiently lubricated I directed my prick towards its target and pushed it in. She drew a great big breath when I did so and let out a loud moan. I proceeded to pump in and out and she began to respond. She began to moan loudly and to buck her ass back and forth almost reaching out and pulling my prick into her ass. It was not long before I exploded and shot my wad into her ass. As I did so, I could tell Mary was reaching an unexpected climax of her own, and she screamed as she let go, a combination of her orgasmic juices and pee flooding down onto the diaper between her knees.
I told her how wonderful it was that she was able to reach a climax while being ass-fucked and that she had *come* a long way in her training. She thanked me for helping her expand her horizons and for fucking her to a lovely orgasm in her *asshole*. She still had a little trouble with that word, but she was getting better.
I told her that it was almost time for her to wear the double dildo, but there was one more "warm up exercise" that she needed. I told her to hold still, and then I proceeded to give her a brisk, sound spanking, explaining as I did so that this was not a punishment, but that I enjoyed spanking her cute ass and that she must learn to accept being spanked until she cried as a part of her everyday life. The only difference between spankings for punishment and those for my pleasure would be in the duration and severity of those which were for punishment. I told her that she should take pleasure from being spanked, if only for the reason that she knew that accepting my spankings would provide me with great pleasure. She did hold as still as she was probably capable, and when I stopped the spanking she was crying openly and could only stammer her thanks for allowing her to please me by accepting her spanking without the need of being bound for it. Her ability to see that she would be bound for spankings if she showed any resistance, and her determination to make that unnecessary pleased me greatly. I went around the side of the bed to retrieve the double dildo from in front of her. I held it up to her lips and told her to kiss both ends and then beg me to place it in her and allow her to wear it inside her diapers for as long as I deemed it necessary. She was still sobbing a little, but she complied very sweetly and with almost no hesitation. I returned to her rear. I knew she was very well lubricated in her pussy and that she was also well lubricated in her ass. I placed the double dildo up against her with one prong touching her pussy and the other nudging up against her rear hole. I gave a push and the glands of the dildos entered their respective holes. I then pushed it straight home and heard her gasp and squeal as she was impaled on two eight inch pricks. I began to move the double dildo in and out of her holes and she began to pant and moan at the action.
I pushed the double dildo home its full eight inches and left it in her. Mary realized that I was waiting for something and she turned and looked at me with pleading eyes as she begged me to diaper her, knowing that the wet diaper between her knees would soon be holding the double dildo firmly inside her. I pulled the extra thick pre-fold diaper up snugly between her legs and pinned it tightly around her waist. I knew that soon it would be sufficiently wet to become loose enough between her legs to allow the dildo to come out of her a few inches when she stood up, but whenever she bent at the waist or sat down the diaper would be tight enough to push it back in, thereby continuing an automatic fucking of her front and back. I allowed her only her diaper as a covering, denying her the protection of plastic panties or a top to cover her little titties.
I knew that we were running out of diapers and that would be a catastrophe, given her growing incontinence and my plans for the rest of the day. I had a laundry room off my kitchen and I had her gather up all her wet and messy diapers and carry them to the laundry room. I told her that it was one of the duties of a diaperslave to wash her own diapers. I left her to do her diapers as I went back into the kitchen to prepare lunch.
By the time lunch was ready I could see a yellow stain spreading in her crotch. I told her that she could not sit at the table with leaking diapers. Judging from the look on her face, she thought I was going to have her sit on the plastic sheet or something. Instead, I merely pinned another extra-thick diaper on her on top of the one she was already wearing.
I then had her sit down to a delicious lunch of pasta and tossed green salad. I asked her what she preferred as a salad dressing and she picked my favorite, Bleu Cheese. I got out the bottle of chunky Bleu Cheese dressing and handed it to her after I had used it. As we ate, I could see her wiggling back and forth and I knew she was moving the dildo around inside her. Along with lunch, I made sure my little Mary drank three beers, knowing full well where they were headed.
After lunch we went back out onto the deck. Well, I walked and she waddled with the thickness of the diapers between her legs. As we got to the deck, we saw that there were a couple of boats out on the lake, seemingly just going back and forth in front of my cottage.
We sat on the deck as Mary again told me how much she appreciated what I was doing for her and how thankful she was that I was doing such a good job training her. As we talked I could see her moving forward and back, enhancing the sensation of the double dildo impaled within her. I told her that if she really meant what she was saying, she would demonstrate her submissiveness by voluntarily pooping in her diapers. She looked at me with pleading eyes, because that was the one thing she most wanted to avoid, messing her diapers. Oh, she knew that there were times when I would make her to mess her diapers with enemas or even just by making her hold it in until she could do so no longer. But to voluntarily and deliberately mess her diapers was horrifying to her. I reminded her that she was forbidden to use a toilet, and that one way or another she would have to mess herself every day, so she had better get used to the idea. I also suggested that with my regular use of her asshole she might find controlling herself more difficult. That really made her blush.
As we sat there on the deck I could tell from the way she shifted about on the chair that she was feeling the double dildo inside her and that she would do anything to get it out. Or would she? It seemed to me that maybe my little diaperslave was enjoying this latest punishment a little too much. But that would not last.
As we talked further, I saw her try to cover her titties and her diapers with her hand and I scolded her for that action and told her that she would be punished for her disobedience. I reminded her that she had been forbidden to try to cover up her nakedness or her diapered condition. She blushed beet red and as I followed her gaze, I saw why. The people in the boats were using binoculars to get a better look at my little diaperslave. They were leering at my little diaperslave wearing just a diaper with another yellow spot beginning to grow between her legs.
Rather than go back to the bedroom, I told her to stay on the deck and not to cover herself with anything while I went inside to get some supplies. I returned with another extra-thick pre-fold diaper. I told her that before I would change her, she would have to relieve the pressure that was building up in my balls. She realized what that meant and acknowledged that she would comply.
Right then and there, I had her lower my pants and get on her knees in front of me. She knew that we had an audience and that a whole bunch of people were watching her assume this degrading position in front of me. I made sure that as she knelt down, she spread her knees wide in humble submission to me.
This time I did not refuse her the use of her hands and she very gently took my balls in her hands and played with them as she took my cock in her mouth. After she had lubricated my cock with her saliva, she moved her mouth to my scrotum and took each of my balls in turn into her mouth and ran her tongue around them. It felt very sensuous and really turned me on. She returned her mouth to my cock again and really massaged it up and down with her mouth and tongue. I could see her blush quite red as I told her that she must really enjoy sucking my cock because she was putting so much care and attention into doing it properly and lovingly. She knew just how long to wait before she brought me to climax and she swallowed every drop of my semen and then licked me completely clean.
I stood there for a minute before she realized she had not yet thanked me for the privilege of letting her suck my cock and after she had properly thanked me, she begged me to change her. I told her that it was highly presumptuous for a little wet diaperslave to ask to be changed. I told her that I had set a schedule for changing her, and that I would change her when I was ready, and not before that. I did say that there might be occasions when she felt that her diapers were about to leak, or when she had messed herself very thoroughly that she might find it necessary to call my attention to the situation. In those cases I said that she could very politely request me to *check* her diapers, but never ever to suggest that they might need changing. I didn't think she could blush that hard, but even the tops of her titties turned red. She really had to make out her acknowledgement of my authority and her promise never to ask to be changed again.
Then I told her to lay down on the deck, that for her impertinence I was going to change her right then and there. She looked out on the lake at the two boats that were there and could see that the occupants were still availing themselves of the use of binoculars so they could see everything that was happening on shore.
Knowing that the whole changing routine would be observed, she lay down on the deck as I told her, with her feet facing the lake. I took off her wet diapers and left her laying there with her feet spread apart, her knees splayed and upraised, and her cunt facing the lake while I took her wet diapers into the bedroom and put them in the diaper pail. I warned her not to let the dildo come out while I was gone. I knew that she would use that time to fuck herself with the dildo, even though she knew she was being watched all the time. I returned and, as I moved the dildo in and out of her, I told her that she was no longer to refer to her pussy as anything other than her "cunt," a word I knew was obnoxious to her. A look of horror came over her face as she realized that she was going to be maked to use that word when referring to her private parts. Then I twisted the dagger a little further, telling her that she no longer had any right to privacy at all, and that it was obvious from her admiring audience that her *cunt* and *asshole* were now her "public parts"! She blushed even redder, and tears rolled down her cheeks, but she did manage to look at me adoringly and say, "Yes, my Master, whatever you wish!" I noticed that there was considerable juiciness oozing around the dildo in her cunt.
Keeping the double dildo securely inside her, I pinned the extra heavyweight pre-fold diaper around her waist. I told her that she was not to wear anything but this diaper for a while and that if it got too wet, I would again just pin another one on top of it, adding to the bulk between her legs. I warned her that if her pee overflowed her diaper she would pay the consequences. I told her to ask me to check her diaper before it was so full that it would drip, and that any mess on my deck from her diaper would bring severe repercussions. By now, her diapers and plastic panties had finished in the washer and I told her to get them and to hang them up on the line in my back yard, the one which extended from my deck to a tree down by the lake. She really blushed as the binoculars in the boats were focused on her hanging up her diapers and plastic panties to dry, pinning them on the line like a ship's flags signaling her diapered status for all to see.
When she had finished hanging up her diapers I told her to wave to the nice people out in the lake. She blushed all over as she did as she was told. She stood there watching them watch her through their binoculars, with her little titties standing as firm as they could and her diaper sagging between her legs, and she raised her right hand in the air and waved at them.
A mixed look of surprise and apprehension came over her face as she watched the two boats head toward shore, right to my dock. Her apprehension turned to terror as the occupants tied up their boats at the dock and started walking toward the cottage.
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Social media is bad for us! Social networking is good for our society! If it didn't happen on the Internet, then it didn't happen in real life! We cry out about the good, the bad, and the ugly that is social media, and while platforms like Facebook, Twitter, and Instagram become a more integral part of our daily lives, there is no denying that there is a certain impact they create. There's nothing wrong with posting a picture of a sunset or rock climb with the intention to share our warm fuzzies with loved ones, especially when we don't get to see friends and family on the daily. Thank goodness for things like FaceTime and Instagram. Apps such as these have made it possible for me to stay connected with the people that I love, as well as make new connections in a meaningful way.
Ultimately, it's a way for me to share my experiences with people that I care about. I want my mom to see that beautiful sunset. I want to share my enthusiasm about climbing with anybody else who is enthusiastic about climbing. These are all essentially good things, right?
Social media life is not my real life though, and could never be a replacement for it. I am sorry for anything I've ever written or posted that has implied anything but the truth. I'm not climbing or enjoying the great outdoors one hundred percent of the time, or even close to that—and I know that. You should, too.
No matter the social media platform you choose to use, there will always be gaps and missing context from your storyline. Me, for example? I used to live in my vehicle and on the road but moved to Denver this past fall. I now live with a snuggly fish face kitten and the most awesome, kind-hearted roommate a girl could ask for. Sometimes, I get paid to write, but I started teaching kids again. Now, I'm nannying part-time and trying to fill the rest of my time with rock climbing.
The fact is, a majority of us can't be climbing seven days a week. I'm certainly not. Even if that's not what you're seeing on my Instagram, that's the reality of it. Social media is making it difficult for us to separate reality from the Internet. This year, I took a step back from my own social media. I realized that if I give it too much of my time, I am living in a completely different world. It steers the focus away from things I really wish to do, the people I really love, and the relationships that I want to nurture. I try not to use social media as a cure for boredom or a place to spray, but rather a place to share my thoughts with those interested in hearing them. At the end of the day, that cool route was still climbed regardless of the filter used and everybody saw the same sunset.
Cameras can only capture so much, anyway. They can't capture belly laughs or that feeling in your gut you receive when you finally reach the point where the summit meets the sky. Incredible things happen, undocumented and unfiltered, everywhere in the world at any given moment. What the evening dusk tells me as it falls around me in ethereal beauty is: How we live our life is far more important than how we say we live our life.


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Southpaw Regional Wrestling is back with six more episodes … and they were well worth the wait!
The second season takes place a year before Lethal Leap Year and centers around an event called "Showdown at the Swamp." No sign of Big Bartholemew, but many new characters are introduced.
- Renee Young as the mysterious Susan referenced in Season One.
- AJ Styles as Malibu Al
- Miz as "Astonishing" Adam Düng
- Rhyno and Seth Rollins as The Butchers
- Jason Jordan as Porkchop Jones
- Natalya as Debbie Desperado
And many more!
BONUS: WWE also released a ton of merch for Southpaw that can be found HERE!
Watch the new episodes below.


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Our luxurious Bath Bomb donuts are hand crafted with lots of patience and time. We work to create the perfect mix of a beautiful bath bomb with with the moisturising effects we all love. This one is popular with the kids.
Scent: Fruity and fresh like a fruit cocktail on the beach. Very refreshing.
Usage: Use 1 per bath. Fill your tub and either before entering or after place on the water gently and watch the donut fizz and foam. You will feel the difference as your skin soaks up the silky moisturising goodness of the Cocoa Butter.
May make tub slippery. No staining and minimal cleanup on the tub use hot soapy water if needed.
Size: 75mm diam x 35mm
Weight: 130g
Ingredients: Sodium Bicarbonate, Citric Acid, Cocoa Butter, Fragrance, Cosmetic Glitter. Topping Sugar/Salt.


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The Indian Army Recruitment system is designed to detect and eliminate unfair means of admission. At every stage there is thorough scrutiny to ensure that only the right candidates get through. In spite of this, there are some individuals who lure candidates under the pretext of granting them admission into the Indian Army.
The physical criteria, the entrance exams, the physical fitness tests and the medical assessments are all put in place to ensure that the candidate does have it in him to prevail in the most trying conditions. Compromising on these would mean putting the individual, his team members and the mission at risk. Hence, the Army is very particular about the recruitment process.
Below are a few points the Indian Army wants every candidate willing to join them to be aware of:-
- Please be Wary of Touts(Dalal). They cannot influence the recruiting procedure at all. They are liars and take advantage of your lack of knowledge of the recruiting procedure. The army recruiting is absolutely free, fair and totally merit based. Individual having the required qualifications and capability will get selected on his own steam. No one can change the procedure to push in undeserving candidates since the procedure has stringent checks and balances and mostly automated. Therefore when you come for recruitment, have self belief. Anyone offering guarantee of recruitment must be reported to police or the rally officials immediately. Over a period we have identified many methods a tout adopts to lure candidates. They are given below for you to ward off any such offers.
- Likely Victim. Before a tout targets a candidate, he checks the candidate thoroughly. Normally he selects boys who are physically fit with no medical problems and would in all probability be good in studies. Such candidates generally pass on their own steam. He gives false assurances and says "You just pass the run. I will get the rest of it done." When a candidate passes in such case, the tout will take the credit. If the candidate gets rejected, the tout returns the money or at least a major part of it with a lie that "some money, I can't give back since I gave it to officials; however they have assured me that they will definitely do something next time, since there was lot of strictness this time".
- Tricks To Acquire Candidates Trust. The tout will do anything to acquire the candidate's faith so that they give him money easily e.g. in the middle of a recruitment rally, the tout will go up and make a deliberate effort to shake hands with recruiting personnel claiming to be an ex-servicemen or any other identity. Mind you, he will want you(candidate) to notice this and then he capitalizes on this hand shake.
- Telling Candidates False Indicators. Tout will misleadingly say "wear this coloured vest (baniyan)/Shorts, I've told the people concerned. They won't ask you anything but will know that you are my man." or
- "When you go for the interview of the Director Recruiting, say 'Namaste' or touch his feet. He will understand."
- No one but only you can make it through the recruitment process, if you have the qualification and capability. Don't lose your parents hard earned money to unscrupulous touts.


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CHICAGO, ILL., Mar 29, 2018 – Loyola Chicago University Campus Bookstores are opening additional retail locations in response to Loyola Basketball excitement. Earlier this week, the bookstore opened a pop-up location at 822 N. Michigan (at Pearson, across from the Water Tower). On Friday, the Lakeshore Main Store will expand into temporary space adjacent to the Lakeshore Campus store at 6435 N. Sheridan Road.
"We are excited for the team and the community and thrilled to help students and fans show their Loyola pride by expanding our space and bringing in additional apparel and items in front of the big game this weekend," said Stacy Zapko, Bookstore Group Vice President. "In addition, we are distributing free cheer cards to our customers while supplies last. We want to thank everyone for supporting the bookstore."
Our locations have a fantastic selection of new products arriving daily such as the Nike Loyola Final Four T-Shirts, the popular "Breaking Hearts and Brackets" Tee, as well as Sister Jean items and a new shipment of Loyola striped scarfs. Merchandise is flying off the shelves as soon as it is put out, but our suppliers have additional items arriving hourly.
Loyola Chicago University Campus Stores welcome the entire Loyola Chicago University community – including students, parents, alumni, fans, faculty and staff – to shop at our stores and gear-up for the "David vs. Goliath" game Saturday, March 31 against Michigan. For students attending the campus viewing party on Saturday, the main bookstore and the bookstore located in the Alumni Student Center will be open Saturday.
Loyola Chicago Store Locations & Hours This Week:
Lakeshore Campus Main Store
6435 N. Sheridan Road
Thursday, 8:30am to 7pm
Friday, 10am – 4pm
Saturday, 10am – 4pm
Lakeshore Campus "The L Stop" Spirit Shop
Loyola University Alumni Student Center
6511 North Sheridan Road
Thursday, 10am – 4pm
Friday, 10am – 4pm
Saturday, 10am – 4pm
Watertower Campus Store
2nd Floor Baumhart Hall
26 E. Pearson Street
Thursday, 9am – 6:30pm
Friday, 10am – 4pm
Saturday, 10am – 4pm
Michigan Avenue Pop-Up Store
822 N. Michigan Ave (Across from the Water Tower)
Thursday, 10am – 5pm
Friday, 10am – 4pm
About Loyola University Lakeshore Campus Store
Loyola Chicago University Lakeshore Campus Store is devoted to serving the Loyola Chicago University Lakeshore Campus community – offering products and services to students and the local Chicago community both in-store and online via our website LoyolaChiShop.com. The main Loyola Chicago University Lakeshore Campus Store is located in the Granada Center, 6435 N. Sheridan Road.
About Follett Corporation | www.follett.com
Follett is a $3.4 billion privately held company headquartered in Westchester, Illinois. As a leading provider of education technology, services and physical and digital content, Follett works with 70,000 schools and operates more than 1,250 local campus stores and 1,600 virtual stores. With the 2016 acquisition of Baker & Taylor, LLC, Follett's reach also extends into the public library and global retail markets. For more information, visit www.follett.com. For more information on our partnership with Lumen Learning, visit www.follett.com/lumen.
Media Contact:
Follett Corporation
Tom Kline


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The 14-Day Detox Kit was designed to support the body's natural two-phase detoxification process. This is accomplished by providing the nutrients needed to support and balance phase I and II metabolic pathways, high levels of antioxidants for safe detoxification, and a comprehensive array of herbs to promote healthy liver function and elimination.
Why You'll Love It:
- All-inclusive, step-by-step kit that makes following a detox program easier than ever
- Includes a 14-Day Detox Guide, which directs you throughout the entire detox program
- Includes non-GMO and great-tasting protein powders
- Provides supporting vitamins and supplements to encourage detoxification*
- May increase brain function and energy*
- Supports weight loss*
- May encourage vitamin, mineral and hormone absorption*
What the 14-Day Detox includes:
- Pure Cleanse Detox Powder
- Pure Pea Protein Powder
- My HotzePak Detox Pak including Free Form Amino Acids & Digestive Enzymes
- Detox guide booklet
- Tote bag
Customer Reviews
- by SB
- Convenient I loved the detox smoothies! It's hard to believe that 14 days can make such a big difference. (Posted on 4/26/2016)
- by Kelly
- A new perspective on my health The 14-Day Detox Kit is fully inclusive with everything you need. I was able to gain momentum in weight loss, as I had reached a plateau, and learned so much about how to live a toxin-free, healthier life. I was also able to survive without coffee and have developed a love for herbal tea in its place! (Posted on 4/26/2016)
- by Gifty
- Easy! Loved it! Easier to follow than the yeast-free diet. The bloating I was feeling left the first 2 days. (Posted on 4/26/2016)
- by Lisa
- Easier than Yeast-Free The 14-Day Detox program left me feeling less bloated and more energetic. I thought "drinking" two meals a day would be really difficult but the smoothies made me feel full and satisfied. This was actually easier to do than the yeast-free diet and my clothes fit a little better, too! (Posted on 10/29/2015)
- by Nicole
- Loved it! I successfully completed the 14-Day Detox and loved every single day of it! The powders make delicious smoothies and I just felt great overall! I still drink one detox shake every morning for breakfast. I highly recommend this kit to anyone looking to reset their body and get back into the healthy eating kick! (Posted on 10/1/2015)


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World Policy On Air, Ep. 50: The Death of Nimr al-Nimr
January 15, 2016
The fallout from the execution of Shiite cleric Nimr al-Nimr in Saudi Arabia earlier this month succeeded in further isolating Iran from the Arab world. On today's episode of World Policy On Air, World Policy fellow Jonathan Cristol discusses the escalating tensions between the two rival powers in the Middle East and the likely consequences as the drama plays out over the next year.


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Day 1 | Day 2 | Speaker Bios
Wednesday, August 18
12:15pm Registration
1:45 Chairperson's Opening Remarks
Susan Dana Jones, Ph.D., Vice President and Senior Consultant, BioProcess Technology Consultants
Cytokines and Toll-Like Receptor Ligands as Adjuvants to Improve the Quality as well as Quantity of T Cell Immune Responses
Jay A. Berzofsky, M.D., Ph.D., Chief, Vaccine Branch, Center for Cancer Research, National Cancer Institute (NCI), National Institutes of Health
We have examined cytokines and synergistic combinations of toll-like receptor agonists as defined molecular adjuvants to improve not only the quantity, but perhaps more importantly, the quality of the T cell immune response to vaccines. In particular, we find that IL-15 as an adjuvant can select for higher avidity CD8+ T cells that are more effective at clearing virus infections and tumors, and can also substitute for CD4+ T cell help to induce long-lived memory CD8+ T cell responses. We have also found two double combinations of TLR ligands that can synergistically increase the magnitude of CD8+ T cell response as measured by tetramer staining, as well as increase the activation of dendritic cells. However, only a triple combination of TLR ligands was sufficient to induce strong protection against a vaccinia virus challenge of mice, and this protection depended not on a further increase in T cell numbers, but rather an increase in their functional avidity. Biography
2:30 Modulating Vaccine Responses with Innate Immunity
Bali Pulendran, Ph.D., Professor, Pathology, Emory University School of Medicine
Despite their great success, we understand little about how effective vaccines stimulate protective immune responses. Two recent developments promise to yield such understanding: the appreciation of the crucial role of the innate immune system in sensing microorganisms and tuning immune responses, and advances in systems biology. In this presentation, I will discuss how these developments are yielding insights into the mechanism of some of the most successful vaccines ever developed. Furthermore, such developments promise to address a major challenge in vaccinology: that the efficacy of a vaccine can only be ascertained retrospectively, upon infection. The identification of molecular signatures induced rapidly after vaccination, which correlate with and predict the later development of protective immune responses, would represent a strategy to prospectively determine vaccine efficacy. Such a strategy would be particularly useful when evaluating the efficacy or immunogenicity of untested vaccines, or in identifying individuals with sub-optimal responses amongst high risk populations, such as infants or the elderly. We have recently used a systems biology approach to identify early gene signatures that correlate with, and predict the later immune responses in humans vaccinated with the live attenuated yellow fever vaccine YF-17D, or with the influenza vaccines. I will review these studies, and discuss their broader implications for vaccinology. Biography
3:00 TLR3 Adjuvants Improve Oral Gene-Based Immunization
Sean Tucker, Ph.D., Founder, VP Research & CSO, Vaxart, Inc.
Oral gene-based vaccination has several potential advantages over current injected vaccines. Among these advantages are the ability to quickly distribute vaccines to areas of the world where medical care is inadequate or disrupted, to permit rapid transition from antigen gene to product through well-characterized manufacturing methods, and potentially, to avoid the problems of pre-existing immunity to the vector. The problem is that oral vector vaccination has generally performed poorly in larger animal models. Vaxart has developed an expressed TLR3 adjuvant that has substantially improved the oral vaccine performance, making oral immunization better than an injected vaccine and protective against diseases such as influenza and Venezuelan Equine Encephalitis. Unlike an injected vector, the immune responses generated are substantially selective against the antigen of choice, making this a platform, not a single use technology. Biography
3:30 Ice Cream Bar Refreshment Break with Exhibit and Poster Viewing
4:15 Toll-Like Receptor 4: The Use of MPL in Vaccines – Efficacy and Safety Evaluation
Nathalie Garçon, Pharm.D., Ph.D., VP, Head of Global Adjuvant Centre for Vaccine Development, GSK Biologicals
Improved understanding of the important role of TLR signalling in the induction of adaptive immune responses has led to the discovery of TLR agonists. A strong immunostimulant and a specific TLR4 agonist guiding the immune system towards a Th1 response is lipopolysaccharide (LPS). 3-O-desacyl-4′-monophosphoryl lipid A (MPL), a derivative of LPS, is to date the best characterised TLR-4 agonist, and is part of the adjuvant combination AS04, an Adjuvant System consisting of MPL adsorbed onto a particulate form of aluminium salt. As LPS, MPL acts via TLR4 pathway, resulting in a transient and localised enhanced production of cytokines and chemokines leading to the maturation and migration of APCs to the draining lymph nodes. This results in improved adaptive immune responses as evidenced by increased antibody titres and memory cells. Preclinical data show that MPL has no direct impact on effector T and B cells. AS04 is currently used in licensed vaccines for HBV (FENDrix™) and HPV (Cervarix). An AS04-containing candidate vaccine, for HSV, is currently in phase III clinical trials. AS04 has consistently demonstrated its ability to induce a high neutralising antibody response. Both the HPV vaccine and HSV candidate vaccine elicited increased antibody levels at the site of infection via transudation from the serum to the mucosa. The HPV and HBV vaccines induced more durable protective antibody levels, thus decreasing the number of vaccine doses required. In clinical studies, AS04-formulated HPV and HBV vaccines have been shown to have acceptable reactogenicity and safety profiles comparable to classic aluminium adjuvanted vaccines. Biography
4:45 Enhancement of Response to Vaccines with the Use of an Immune Modulating Peptide, Thymosin Alpha 1
Israel Rios, M.D., CMO & Senior VP, SciClone Pharmaceuticals, Inc.
Thymosin alpha 1 (trade name Zadaxin®) is a 28 amino acid immune-stimulating peptide that was originally isolated from thymic tissue and is now produced by solid-phase peptide synthesis. Thymosin alpha 1 has been shown to activate toll-like receptor 9 (TLR9), a cell surface receptor that plays a key role in triggering the body's innate and adaptive immune responses, allowing significant increases in antibody production and clearance of viral infections. In preclinical studies, treatment with thymosin alpha 1 led to increased influenza-specific CTL responses following vaccination. In clinical testing in immune compromised or elderly subjects, bi-weekly doses of thymosin alpha 1 given for 3 to 4 weeks after vaccination resulted in improved response to hepatitis B or seasonal influenza vaccine. Thymosin alpha 1 is one of only a few immunomodulating compounds that have been approved for human use and does not appear to induce the side effects and toxicities commonly associated with agents in this class such as interferon and interleukin-2. Taken together, these observations support the rationale for further clinical investigation of thymosin alpha 1 as an adjunct to vaccination. Biography
5:15 Vaccine Immune-Enhancing Delivery Systems:
From Danger Signals to a Nutritive Approach in Vaccine and Adjuvant Design
Michael Vajdy, Ph.D., CEO, EpitoGenesis, Inc.
Since the dawn of ancient and modern vaccination strategies the focus of vaccine developers has been to activate danger signals in the host cells in order to mimic the pathogen. While this approach has yielded several effective vaccines which in some cases have eliminated the disease altogether, in some other cases it has proven toxic. Indeed, as recently as two years ago a live attenuated based HIV vaccine was proven to be unsafe. Also recently, a mutant toxin-based adjuvant also proved to be unsafe in Phase I Clinical trials. In this talk I will give an overview of various popular vaccine adjuvant and delivery systems, leading to our own approach in this area: Given the crucial issue of vaccine safety we opted for an approach in vaccine design in which we addressed the safety issue first. Thus, we selected components of a nutritive vaccine immune enhancing delivery system (NIDS) based on their proven safety in humans as edible nutrients. We have now tested the NIDS mixed with antigens from viral and bacterial pathogens in animal studies and demonstrated higher antibody and CD4-derived cytokine responses compared to vaccinations without NIDS. Our studies demonstrate that this approach is effective and by definition safe and may lead to a new era in vaccine and adjuvant design. Biography
5:45 Vaccine Adjuvants and Regulatory Considerations
William M. Egan, Ph.D., Vice President, PharmaNet Consulting
Live-attenuated viral and bacterial vaccines (including vectored vaccines), as well as many older generation vaccines (such as the various killed, whole-cell vaccines), were "self-adjuvanted," incorporating molecular motifs that are recognized by, and activate, the innate immune system. Many newer vaccines, such as those based on recombinant proteins, will require vaccine adjuvants and, moreover, will often require non-aluminum salt based adjuvants. The development of appropriate adjuvants for particular vaccines, both from efficacy as well as safety viewpoints, will, ideally, be based on the known mechanisms of action of the potential adjuvants; these considerations may, as well, be influenced by the intended vaccine recipient population, for example, neonates or the elderly. Regulatory decisions, either to allow a clinical trial to proceed or, eventually, to license a product, will be based on perceived or demonstrated risks and benefits associated with the particular vaccine and its associated adjuvant. This presentation will discuss a number of factors (such as, adjuvant manufacture and characterization, pre-clinical studies supporting efficacy and safety, risk-minimization strategies, and eventual Phase 4 studies) that may be incorporated into such risk-benefit algorithms. Biography
6:15 End of Day
Day 1 | Day 2 | Speaker Bios


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"Part of the Act" is a comic opera in one act with libretto by John Grimmett and music by Liam Wade.
Please consider supporting my "Part of the Act" recording project with a tax deductible donation.
We have assembled a fantastic group of musicians for this recording project including two original WNO cast members, Julia Mintzer and Shantelle Przybylo, who were joined by two celebrated Philadelphia area musicians, pianist Louis Menendez, and John Packard singing the role of Seamus McGinley. The recording project took place March 23-25, 2015 in Philadelphia, PA.
You can listen to the studio recording here!
Recorded 03/25/15 by Ian DeNolfo and Lloyd Joseph Frank at Lion Media Creations,
Bryn Mawr, PA.
Shantelle Przybylo – Ginger Taylor
Julia Mintzer – Mabel McGinley
John Packard – Seamus McGinley
Louis Menendez – Piano
Lisa Willson – Piano effects and voiceover
Produced by Liam Wade
Copyright © 2012-2015 Liam Wade and John Grimmett.
Endless thanks to librettist John Grimmett; our amazing cast, John Packard, Julia Mintzer, Shantelle Przybylo and Louis Menendez; and Ian DeNolfo, Lisa Willson DeNolfo and Lloyd Joseph Frank at Lion Media Creations; and the amazing donors and supporters who making this recording possible!
Please consider supporting my "Part of the Act" recording project with a tax deductible donation.
We are getting closer and closer, only about $400 away from reaching our fundraising goal of $3,586 to pay for this wonderful recording! Any donation, small or large that you could share with us would be a big help!
Your donation will go directly to paying the performers and for studio and editing costs, and make it possible for this innovative new chamber opera to be heard.
Fractured Atlas is a 501(c)(3) public charity. Contributions for the purposes of Part of the Act Recording are tax-deductible to the extent permitted by law.


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