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To be quite frank, I wasn't as excited as many for the arrival of GTA V today. The few who I have spoken to seem to be on the verge of wetting themselves in anticipation for their copy of the game, even amongst the multitude of Instagram and Facebook photos that leaked all over the internet days in advance. It's like they think people have never seen a game before. Come on guys, it's not like the release of Final Fantasy XV as that would be a cause for excitement! But even with my indifference to the franchise, I can't argue its popularity. Therefore, this week's Retro Recap is none other than the game that started it all off, the first Grand Theft Auto!
The first game differs in many aspects from the more recent versions, notably the camera. GTA was originally a top down view, which warranted a number of merits. Firstly, it made it easier to see the surroundings and assess the situation in such a way that camera-behind-the-player views cannot. That is not to say that top down views are better, yet there's just something unique about being able to see more of the map than you normally would. Another feature that has been lost in the modern versions is the way the game progresses. Later GTA's are the typical quest based storylines that we've all come to know (not necessarily love), yet the first GTA was a points based system. You didn't even need to do the main missions set out for you. You could literally go through the game doing as the game describes and stealing cars and killing civilians. How times have changed. To certain extent, you could say that this is the most free roaming GTA game of the entire franchise.That's a lot of police…
You can choose between a variety of starting characters, albeit the play style is exactly the same for each one and you progress through each location, moving onto a different place when you've accumulated enough points. Each location are the places that many GTA fans have come to familiarize themselves with. You begin in Liberty City, move onto Vice City and finally San Andreas. Each new map provides a fresh look on the gameplay and progresses you through the basic story of your dealings with local crime syndicates. In order to navigate said worlds, one must acquire a vehicle of some sorts. I know what you're thinking, with enough hard work, the protagonist (antagonist?) could save up for a sweet ride. Or steal the nearest car and replace it with a faster one when spotted. This is where the title of the franchise lives up. Can you even buy vehicles in GTA? I don't know, I've never played past GTA 1, yet somehow, it would ruin the whole image of the game if you could. Besides, everyone knows a stolen Impaler is better than any other vehicle you could ever get (and had the best name too).
So where exactly is the fun in breaking the law and becoming a mass murderer? GTA seems to have this inane ability to soothe the soul. On one particular level for example, you can find the hidden tank and just go ham all over the map. Blowing up various vehicles because they were there, inciting police confrontation, only to rampage through them and cause all hell of destruction. You can't tell me that ain't fun. After a particular stressful day, nothing is more satisfying is cracking on a video game and committing mass homicide.Just look where this joker has parked!
Fun fact about GTA that all the die-hard fans (not the movie) already know:
- The first GTA was almost cancelled due to production issues
- You accumulated more points by running over pedestrians with a Police car than you did with a regular one
- If you removed the CD from the tray and replaced it with an audio CD, it would play a random track from that the next time you entered a vehicle
- Grand Theft Auto was originally named Race 'n' Chase
- The front cover of the game is of a NYPD 1980's Plymouth Gran Fury rushing through the intersection of 5th Avenue and 56th Street with Trump Tower in the background (if that means anything to anyone)
- Not the first GTA but R2, R2, L1, R2, Left, Down, Right, Up, Left, Down, Right, Up. I didn't even own the damn game
Despite what conceptions this article may provide, I did actually enjoy playing GTA (and others too), albeit never owning once since the first installment. As mentioned, it is definitely satisfying to run around with your favorite weapons and proceed to beat the living daylights out of anyone who was in the vicinity (mostly prostitutes of course). The simpler nature of Grand Theft Auto 1 provided a lot of fun back then, but fans of the series begged for more and more, leading to the gigantic size of the current GTA map. Is there such a thing as too much to do? GTA V will definitely tell you soon enough.
What was your experience of playing the first GTA game? Did it make you become a fan of the franchise? Could I give it a negative review without being heckled to no end? Let us know in the comments section below!


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MAME .221 ROMS DVD Set
by Steven
Truly excellent service. Great communication and shipping. Everything as described. I really exceeded my expectations. I'm glad to have these updates. Great memories to look back on and enjoy. New ones to discover too.
Rating: [5 of 5 Stars!]
Rating: [5 of 5 Stars!]

subset: commoncrawl


text: Fashion and Beauty Moisturising rules all beauty experts live by With so many right and wrong ways to look after skin, we've gone back to basics to update your beauty routine to give your skin a youthful boost With so many right and wrong ways to look after skin, we've gone back to basics to update your beauty routine to give your skin a youthful boost Apply your moisturiser properly Watch our video below to learn how to apply your moisturiser properly to achieve smoother, younger-looking skin. Ditch the rich creams A thicker cream won't give your skin more moisture. In fact, richer creams can actually trap dead cells so skin is left dull. Instead, layering skin with serums under moisturiser will boost hydration levels. Serums are light and easily absorbed but have super-concentrated youth-boosting ingredients. Deep clean your skin Exfoliating in winter causes a boost of cell renewal so new cells can move to the surface making your skin glow. Exfoliation does weaken your skin's barrier, but as long as you moisturise regularly and use a weekly hydrating mask, you'll keep it strong. Use Olay Total Effects Featherweight Moisturiser with SPF15, as it fights the seven signs of ageing in just one step. Beauty's best-kept secret Dry skin on your face can be a problem as we age. Oils have become an anti-ageing wonder as they're more concentrated than serums and formulated for different skin types. They hydrate, plump and balance skin without clogging pores. A little goes a long way, but if you're dubious of using face oils, ease yourself in slowly by applying small dabs to dry patches in need of an extra boost, or blend a few drops in with your moisturising cream so you'll reap the benefits without the oily texture. All in the eyes When moisturising around your eyes, use your ring finger as it has the lightest touch and is least likely to pull at your skin. Start at the inner corner, dot the cream from just below your lashes to the outer corner of your orbital bone, patting it into your skin. Moisturising myth Applying moisturiser when skin is damp to trap in moisture is a beauty myth. Moisturiser is diluted this way, so the hydrating effects are less than intended, and you won't reap the true benefits. Blot skin dry before using, then smooth on Olay Regenerist SPF30, a lightweight SPF formula you won't even notice on your face, but delivers a firmer-looking skin that you definitely will! Sleeping beauty Eight hours' sleep is the golden rule. This is when skin's cell turnover is at its most active, so cells work overtime repairing the damage done in the day. Take advantage with anti-ageing night treatments, such as Olay Regenerist 3 Point Age-Defying Night Cream. It's not called beauty sleep for nothing. What's your simple secret to younger-looking skin? Let us know in the comments section below. You might also like:


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14W DC/DC converters suit railway applications
The DC/DC converters of the PMGS/PCMGS14 series from MTM Power have been designed for transport and railway applications where low-ranged power is needed. The devices operate at a nominal input voltage of 72 or 110VDC and supply an output voltage of 24VDC (12 and 48VDC on request) with a high efficiency of over 90 %. The PMGS/PCMGS14 are available with an input reverse polarity protection by a series diode and are continuous short circuit protected.
The converters operate at an ambient temperature range of -25 to +70°C (EN 50 155, class T3), fulfill the safety standards acc. to EN 50 155, EN 50 124-1 and meet the EMC requirements acc. to EN 50 123-1. The converters are designed to withstand interruptions of the supply voltage up to 10ms and thus, comply with class S2 acc. to EN 50 155.
Depending on the application, they can be used for print (PMGS) or chassis mounting (PCMGS). Optionally, they are available for DIN rail mounting. Depending on the model, the dimensions are 76,0x50,7x22,7mm (PMGS) or 110,0x50,8x23,0mm (PCMGS). The vacuum encapsulated converters are maintenance-free, prepared for the use in devices with Protection Class II. They show a mechanically and electrically rugged design using SMD technology and undergo an automatic piece-by-piece test.


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Contact Us
Red Shadow Kennels is a CKC Registered breeding kennel located in Whitby, Ontario, Canada.
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Seegebarth, Barbara, Backhaus, Christof and Woisetschläger, David M. (2019). The Role of Emotions in Shaping Purchase Intentions for Innovations Using Emerging Technologies:A Scenario-based Investigation in the Context of Nanotechnology. Psychology and Marketing ,
Dreisbach, Jan, Woisetschläger, David M., Backhaus, Christof and Cornwell, T. Bettina (2018). The Role of Fan Benefits in Shaping Responses to Sponsorship Activation. Journal of Business Research ,
Woisetschläger, David M., Backhaus, Christof and Cornwell, T. Bettina (2017). Inferring corporate motives:how deal characteristics shape sponsorship perceptions. Journal of Marketing, 81 (5), pp. 121-141.
Hubert, Marco, Blut, Markus, Brock, Christian, Backhaus, Christof and Eberhardt, Tim (2017). Acceptance of smartphone-based mobile shopping:mobile benefits, customer characteristics, perceived risks and the impact of application context. Psychology and Marketing, 34 (2), pp. 175-194.
Woisetschläger, David M., Hanning, Debra and Backhaus, Christof (2016). Why frontline employees engage as idea collectors:An assessment of underlying motives and critical success factors. Industrial Marketing Management, 52 , pp. 109-116.
Blut, Markus, Evanschitzky, Heiner, Backhaus, Christof, Rudd, John and Marck, Michael (2016). Securing business-to-business relationships:the impact of switching costs. Industrial Marketing Management, 52 , pp. 82-90.
Evanschitzky, Heiner, Caemmerer, Barbara and Backhaus, Christof (2016). The franchise dilemma:entrepreneurial characteristics, relational contracting, and opportunism in hybrid governance. Journal of Small Business Management, 54 (1), pp. 279-298.


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text: Choosing the Right Humidifier for Your McHenry Home Posted February 4, 2016 The winter is always unpredictable, but no matter how manageable or brutal the season is, chances are that you've had quite enough by the end of it. And just when you think spring is around the corner, another cold front comes through. It's crucial to stay ahead of your furnace service, even during the last weeks of the winter, because you honestly never know when you are going to have to use it next. During this time of shifting weather, the air and moisture are also in continuous flux, which might deliver the best opportunity to invest in a humidifier for your home. Humidifiers create important humidity to your house during the brisk, dry air of the winter and can help keep you well in the wintertime. Here are a few things to remember when choosing which humidifier to get for your home: Cost – of course you want to take into account the price, but don't forget to think about the operating and maintenance costs that come with a new humidifier, too. There are numerous levels of efficiency that each humidifier operates on, just like other heating and cool equipment. You will want to take into account the needs of your home's humidity as well as your budget to make sure that your investing in the ideal choice. Size – each humidifier is distinct, but all will commonly have a number that dictates the gallons per day that it can store. This number can typically be calculated by multiplying your home's total square footage by the height of your ceiling. Finding this number and making sure that it agrees with the needs of your home will help determine what size humidifier is perfect for you. Our experts can also help you take into account the insulation in your home, which can sometimes impact the best product to choose. If you're still stumped about which humidifier to get for your home, our pros at Jett's Heating & Air Inc. typically recommend a whole-home humidifier. They deliver the most dependable results throughout your entire home and gives you the most bang for your buck. The coolest part is that it gets fully integrated into your current system, making the installation and maintenance simple for long-term use. Every home is different, of course, and there are a range of factors that one can contemplate before making a final decision on the best humidifier. They aren't talked about as much as furnaces are, even though they are really just as important, so we appreciate if you have more questions or anxieties that you might want to ask our pros before deciding. Give us a call at our McHenry at 815-410-1128. Back To Blog


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Did you like the post yesterday about the Introduction to the Untitled Novel I'm working on? I hope so, because today I'm posting chapter 1 to follow up with it.
I like the idea of titling the chapters. I like the idea of calling the Introduction Before the After, But After the Before. N0 clue what I will call Chapter 1 other than Chapter 1.
Chapter 1
By the time I'd finished scrubbing the stone floor of the kitchen it was already well past 9 o'clock in the evening and dinner had already been served to the students and most of the rest of the staff. My stomach growled with hunger and I went to the pantry to gather something to eat. In a small cauldron I ladled heaping spoonfuls of the leftover chicken stew and smiled. Chef always made the best chicken stew and it made scrubbing his floors every week worth it. On my tray I add a loaf of fresh bread and a large hunk of sharp cheese. Strapping a flagon of cider over my shoulder, I grabbed two spoons and headed out the door to the library.
I heard the boots of the Elder Apprentices before I saw them turn the corner. I searched the stretch of empty hall for a place to conceal myself while they passed. However, the only thing in the hallway was the steadily growing sound of boots colliding heavily with cobblestones. The walls of the school were sturdy from the days of castles and enhanced by one of the Great Mother's enchantments to keep sounds in the rooms from which they originate. This causes the sounds to bounce back into the rooms, or in this case, the hallway, amplifying their volume.
The dark grey robes of the boys in their last year of study at the academy flowed ahead and I groaned inwardly when I realized it was Sadie Robbins and his partner in crime, Jeremiah Blankenship. They both had advanced in the Majiks classes quickly, but through the general classes very slowly. This resulted in them having a lot of power but no sense to go with it. I stopped and placed my back to the wall, holding tightly to the tray in my hands until my fingers hurt. As they drew closer I bowed my head as was customary.
Staring at the dark green of my surcoat which identified me as a high-level servant of the Academy, I began reciting my multiplication tables to keep my focus off the two boys drawing nearer. "Well lookie here, Jeremiah, it's little Maurice with his dinner." They had come to a stop in front of him. Though I had already shown respect, I kept my head down, tracing the gold stitching at the bottom of my surcoat with my eyes.
"Wow, that sure is a lot of food for little Maurice." Jeremiah's deep voice chuckled dumbly, "Maybe we should help him eat it, eh Sadie?" Jeremiah's thin fingers reached out for the loaf of bread and I gripped the tray of food tighter.
"Hello, Gentlemen," my mother's voice rang out behind us. "How are we doing this fine evening?" She gently floated over to us and landed back on the ground with a soft puff.
"Very well, Madame Hiamond." Sadie said, bowing his head. There was a pause and my mother huffed slightly. Tilting his head gently to his compatriot, Sadie elbowed Jerimiah in the chest.
"Oi!" grunted Jerimiah, "What-"his error suddenly dawned on him and his eyes widened and in his haste to make up for the disrespect he showed my mother, a senior member of the teaching staff at The Academy, he bowed so low and so quickly that his head slammed into my tray sending the entirety of its contents into the air. My mother rolled her eyes and held her hand palm up and the flying food. Before I could register my shock at the tray's demise the tray and food suddenly froze midair.
"We would certainly hate to make Maurice's job any more difficult by giving him another mess of yours to clean up, now wouldn't we?" My mother stared pointedly at the two boys and without unlocking her gaze she gently flipped her wrist and the tray and its contents righted themselves and returned neatly to my hands.
"N-n-no Ma'am." Jerimiah stammered. My mother's class was the only Majiks class he had received poor marks in. "We was just tellin' your boy how much he needed the extra food to fatten him up a bit. He is a bit small for his age." Sadie sighed and shook his head at his rather dumb friend.
"Well, thank you, but I assure you his health is nothing you need to worry about." My mother's tone was lethal.
"It's not like we was losing sleep about it-"Jerimiah suddenly turned sheepish. Power began emanating from my mother. Her eyes turned a dark green, her aura shuddered, and there was literally electricity cracking through her long blonde hair. Often the students here forgot that my mother is so powerful with majiks because she chose to teach the Domestic Survival Courses, but before teaching she had been in the Legion. Her power was legend.
Even today, when I would ask about it she would just laugh and say, "When we are young, we assume the greatest majik is the most powerful, but that is not so. The greatest majik is the most challenging, and the two are rarely the same."
Sadie grabbed Jerimiah, "Yes, Ma'am, you're absolutely right. We'll just head to Master Sloan's classroom to continue studying Divination." Dragging Jerimiah by the sleeve and not turning back.
"Yes," added my mother without turning to watch them leave, "I have heard you've been having difficulty with the Honors Majiks." She simply turned to me as if nothing had happened and smiled. The electricity faded and her eyes returned to the light green she and I shared. Something more akin to the color of sea foam than the muddy emerald green that appeared when her anger stirred up the Majik.
"I could have handled that." I snapped.
"I have no doubt," my mother's calm voice lingered in the air like a sweet perfume. "I was merely passing through to see how your day was going. I know how long Mondays are because you must scrub the kitchen after your courses." She settled down onto the ground beside me and touched my shoulder. "It is a mother's right to worry." Her gentle fingers were warm against my skin as she tucked one of my curls behind my ear.
"I'm not skinny either." I said, still angry that I'd been forbidden to even speak to Sadie and Jerimiah after the last bout we'd had left Sadie with a bloody lip before his Apprentice portrait. His mother had called for me to be banished from the grounds, but Great Mother forbade it and simply deemed that I was no longer to acknowledge him as I could not control my temper. Since then staff members had always been near when a confrontation arose. No doubt it was Great Mother's doing.
"I would never say such a thing." My mother said, floating again to kiss my head. "Send Clarenda my love." She said nodding at the two bowls and spoons on my tray and ignoring my obvious eye roll. "I will see you tonight in chambers." And with that she floated down the hallway.
Thoughts of my mother filled my mind as I continued my walk to the practice rooms in the back of the library. How could a woman so powerful give birth to a son with no Majik at all? If it weren't for the obvious physical traits I inherited, I would wonder if she were really my mother.
She'd been so powerful in the Legions that she still was unable to tell me exactly what she did for The Marsters. All I know about that time in her life was why she left. "Love." She would say as if that were a definitive answer. "Between you and your father, I was so filled with love I would no longer continue down that path." Whenever I press for more information, she would shrug and say something non-committal about not really needing more of a reason than that.
I would often blame my father for my lack of power, but my mother would suck her teeth at me, "Power is not always what we assume it to be." She would say. She rarely spoke of my father. I assumed something terrible had happened to him in the war with the tribes. My mother's voice always cracked when she would speak of him. But, sometimes she would tell me of his dark hair which fell in curls around his face. That was when I stopped keeping my hair clipped close to my head as was the current fashion. I didn't have much of a link to my father, but I knew he was tall and lean, like myself, and had shaggy curls.
He was High Military and wasn't supposed to love my mother. But, is anyone ever really supposed to fall in love? My mother left the military when I was conceived and around the same time moved out to The Academy. "Sometimes," she would say in answer to why she was no longer with my father, "Love is so strong it cannot be contained. Most people do not like strength without control." When it came to love and power, my mother was annoyingly profound.
As the large wooden doors to the library flung open, the must of aged papers rushed over me. I breathed in the familiar and comfortable smell and a sigh escaped me. Stepping forward I smiled. "New texts have arrived!" The tiny librarian shouted at me, popping up from behind her desk with so much enthusiasm she nearly toppled backwards. Her short pink hair was standing on end and framed the tanned skin of her cheeks. She bounced over to me with a stack of new books for me to review. I smiled and set the tray down on one of the nearby shelves. "I thought you might like first crack at them." She handed the stack to me and her hand delicately brushed around my wrist.
"Thank you," I said as I began reviewing the titles, "it looks as though you have something in your eyes, Marcie," I said while her eyelashes continued to flutter aimlessly.
"Oh," I could hear her voice drop an octave as I pulled two books from the stack, "It must be all the dust. I've done a lot of organizing today."
Smiling, I handed the remaining books back to her, I said, "that must be it." Marcie was brilliant. She had enrolled in the non-Majiks program at the Academy with me when we were children. She had advanced so quickly Great Mother offered her the position of Librarian when Mr. Winthers retired last year.
Glancing at the texts I had selected, "Animals of the Great North," She pointed at the dark blue book, "I read that one this morning." The book was 3 inches thick, "it's fascinating. Though, personally, I could do without all the anatomical explanations."
I stared at her slack jawed and opened the book. "Marcie, there are over twelve hundred pages in this text, and you read it already?" She flushed slightly and nodded. I always took pride in my intelligence; I may not have Majik but I was bright. Marcie, however, always innocently eclipsed me. There was a slight POP and thick orange smoke billowed out from under the far practice room door. A grin seeped across my face and I placed my books on the dinner tray. "Thanks for the books, Marcie, I appreciate it!" I said over my shoulder as I headed back to Clarenda's room.
This particular practice room was referred to as Clarenda's room by pretty much everyone at The Academy because it was the only one she was allowed to use any more. It had been reinforced with charms by the teachers and Great Mother herself to keep Clarenda from destroying it. The school's Advisors had become annoyed with paying for repairs to the rooms and had set a strict budget. In order to stay within the budget, they limited Clarenda to this one room in the back corner.
The thick wooden door shimmered with the charms that had been set upon it to protect it from any number of things, namely fire. Heavy though it was, it opened silently and I stepped into the room without making a sound. Though her back was to me and she was on hands and knees bent over four open texts on the floor, Clarenda said, "Why is your aura so dark?"
"Hello, Carenda, it's nice to see you too. I'm doing well despite the long day. Thank you for asking." I shot at her, setting the tray on the desk and sitting in the heavy duty chair in the corner. The scent of Majik filled the room with the smoky sweet scent that always lingered on Clarenda mixed with the orchid scent of her skin and hair. It was the most comforting scent I had ever experienced.
"And what did you do to Marcie? All of a sudden her obnoxiously pink aura that fills this entire place went out and dimmed to a dull orange." She still hadn't turned from her books.
"Nothing!" I said thinking over my conversation with her, "She gave me some new books." I held them up to the back of her head.
"Hnmh" she murmured, sitting up on her haunches, "What exactly did you say?" she asked with her back still to me.
"Well," I thought hard, "besides saying thank you, I pointed out she had something in her eye." Clarenda's head dropped, "What?" I asked, confused. "Her eyes were blinking all crazy, she said it was the dust."
Clarenda turned to me and stared with open mouthed incredulities. "You're an idiot." She said, finally standing to join me at the desk. The room was small and had the same grey stones as the rest of The Academy, so she crossed it with a few short steps. There were scorch marks in one corner and the looking glass on the far wall was beginning to crack at the edges.
"Not according to my test scores," I placed the books behind my back to keep them safe, "I brought some stew." I indicated to the cauldron with my spoon. Clarenda took it in both hands, closed her eyes and whispered something incomprehensible. The cauldron instantly glowed red and the stew began to bubble and steam. "Thanks." I said, ladling stew into our bowls.
Clarenda broke the bread and took a piece of the cheese. Gnawing on the end of the bread she sighed and said, "You're welcome. It's about the only thing I can do." She was down on herself. "Today, Madeline said I should be a fortune teller at one of the traveling fairs in the tribes since the only things I can do are set fires and read auras. Maybe she's right." There was a sadness in her voice.
"Don't listen to Madeline." I said, "She may be your roommate, but that doesn't mean she knows anything about you. She's just a wicked twit." I added handing her a bowl. She smiled, though I could tell she didn't really mean it. She reached out to take the bowl of stew I offered. Her fingers brushed mine and I shivered from the coldness of her touch. For someone so adept at setting things on fire, her skin was always cold to the touch. Even in the heat of summer her skin remained cool and pale as though even the sun could not penetrate her.
We ate in silence for a while. Our mothers had been friends here at The Academy of Majiks as children, so my mother always took a personal interest in Clarenda, often acting as a second mother. We had been inseparable since we were three. She helped me through coping with not having powers and I've been helping her cope with having too many. There has always been a solid bond between us, and I could tell something was more wrong than just some snarky comment by Madeline.
"Are you going to tell me what's really bugging you?" I asked. Her eyes rolled and she took a large spoonful of stew into her mouth and chewed slowly and pensively, her pale cheeks bulging. The all too familiar tingle on my neck just behind my ear lobes began pinching sharp pain and try as I might I flinched. As soon as my eyes closed dozens of images washed over me, Clarenda was yelling at her mother, holding a piece of paper, a letter, it was burned and dirty and she waved it in her mother's face like evidence of a crime. The room was bright crimson and there was movements in my peripheral vision, but as usual I could not turn my head to see my surroundings. A blinding flash of green lit up my mind and suddenly there was a boy. My age, but larger, with dark hair and freckles. His clothing was unfamiliar and he spoke with an odd accent. I've never seen him before but through his confusion he smiled at me like we were old friends.
As the boy began to fade I felt a sharp sting across my cheek and opened one eye to see Clarenda leaning over me, her hand raised ready to strike me again. Throwing my arms up to shield my face, "Oi! I'm fine, I'm FINE" I shouted just as her hand began swinging toward me again.
Stopping her hand midair she rolled away from me gasping. "What-"her eyes were wide with fear, "was that?" she spat the words at me as if they were choking her.
I'd never before seen Clarenda react to anything like that. She usually was up for anything. Always ready. But, this, clearly scared her. I, of course, had never seen the way I looked when I had what my mother and I referred to as "events" but I knew they weren't pretty by my mother's concerned eyes and demands that I tell no one, even Clarenda, that they happened to me.
"I, I – I don't really know," I stammered, looking around and realizing I had fallen out of the chair and onto the hard floor. My right elbow hurt. Inspecting my arm I saw a large scrape that was just beginning to redden and swell on my forearm. "I just blacked out, I guess." I lied to my best friend, the girl of my dreams. Her face softened and she moved closer to me. The warm scent of Majik washed over me and I smiled. The motion made my cheeks hurt. "Just how many times did you slap me?" I asked, rising from the floor and stroking my face where a welt was clearly forming.
"You were on the floor, shaking, saying weird words that I've never heard before. Your voice. It was all deep and scratchy" She walked up to me and placed the cool of her hand on my cheek. I leaned into the cool softness of her touch and closed my eyes, reveling in the rare moment of physical connection. "Has this happened before?" She asked, removing her hand and righting the chairs.
"Twice." I confessed. "My mother had me examined in The City, but nothing was found to be wrong, and they happened so infrequently, there wasn't much else we could do, so, I've been dealing with them." As I spoke she led me back to my chair and I drank as though I had been in the heat of the sun all summer. She stared at me and I began to feel uneasy. It's not good to see things in your head. It scared me that even my mother didn't know what they were or why they happened to me, but these events seemed to be more powerful each time they occurred. "Please stop staring at me." I said to Clarenda, turning back to my stew. It had gotten cold, but it didn't matter now. I was eating more for the distraction from Clarenda's intense gray stare.
"I'm just worried about you," she said, standing in her defensive posture, hands on hip hair flipped back with a sharp wave of her head.
"Yeah, well, don't." I snapped. Wit becomes me.
"Fine, she said, grabbing a book from the floor. "I've got to work on this summoning enchantment for this week anyhow." Sitting cross-legged on the floor she put the book on her lap, held out her arms, closed her eyes and said, "Arok nek durloc." And waited. Nothing. She tried again. Again, nothing.
After about an hour she'd managed to generate a puff of glittery light, but nothing more. Still, she pressed on. Repeating "Arok nek durloc" until it created a soft rhythmic chant. Sitting back in my chair and exhausted from a long day and the entertainment I provided during dinner.
The thick smell of Majik surrounded me and my dreams took me away. We were in a meadow, Clarenda and I. She laughed and spun us around, finally having mastered the levitation spell. We spun and spun a foot above the long grass that was growing tall in the warm spring weather. I looked at Clarenda and she smiled. "I love you, Maurice," she whispered in my ear and I held her closer. Nose to nose, we smiled and I leaned in to finally kiss her when a blinding flash of green light sent my dream tumbling down to earth. I jumped with a start thinking I was having another event. Forcing my eyes open, I stared in wonder at the scene unfolding before me as if in slow motion.
There, before me, Clarenda was standing radiating energy, from her hair, through to her fingertips and down through her toes. Her eyes a dark plum like midnight on winter's solstice. The air buzzed with Majik and a green light pulsed somewhere in the corner. I couldn't see exactly what was going on, my view obscured with Clarenda's form, but the light suddenly extinguished and Clarenda's arms fell to her side and the lightning dissipated. Whipping around to me, her hair cracked with the remaining static. "Did it work?" she asked, looking around the small room.
In the corner, I saw something move and froze in place. Clarenda followed my gaze and a gasp escaped her lips as she stumbled back into me. "I'd say it worked, yeah." I spluttered. There, in the corner looking a bit stunned and confused stood a boy with dark hair and freckles.


text:
Adopted June 1995 Revised June 2013
Amended July 2013 November 2013 April 2014 July 2014
Issue Date: July 2014
A Member, or their Agent, shall, at all times, ensure that all dogs under that Member's control are properly housed, fed, watered, exercised and receive proper veterinary attention, as and when required.
A Member shall permit any person authorised in writing by the Dogs NSW Secretary, pursuant to a resolution of the Board of Directors, to enter and inspect any premises owned or occupied by the member for the purpose of investigating compliance with Regulation 1 of this Code and during the conduct of the inspection the Member will permit the authorised person to record any necessary details by tape, video or photographs.
Non compliance with Regulations 1 or 2 of this Code is deemed to be misconduct.
A Member commits to compliance with both the Prevention of Cruelty to Animals Act 1979 and the Companion Animals Act 1998 and their related Regulations as well as to the NSW Animal Welfare Code of Practice – Breeding Dogs and Cats.
A Member, or their Agent, shall not allow any dogs which are registered in that Member's name, to roam at large and when away from home, must ensure that they are kept fully leashed or under effective control at all times.
A Member shall breed only with the intent of maintaining and/or improving the standard of the Breed and the health, welfare and soundness of their dogs having regard to the following:-
(i) by striving to eliminate hereditary diseases within their dogs and their breed.
(ii) that the health, physical welfare and fitness for function of dogs is of prime importance, and
(iii) that a Member shall make every reasonable effort to ensure that dogs bred by them do not suffer from any disorder that impedes their sight, breathing or ability to move freely or which is otherwise detrimental to their comfort and wellbeing.
A bitch shall not be bred from unless it is in good health and has reached adequate maturity and, in any case, no matings shall be permitted before the age of 18 months for bitches of Breeds specified in the Schedule of Adequate Maturity for Giant Breeds below or before the age of 12 months for any other bitch. Any litter resulting from the mating of a bitch under the minimum specified age at the time of mating is only eligible to be registered on the Limited Register and flagged "not to be upgraded to the Main Register".
Schedule of Adequate Maturity for Giant Breeds
(Submissions for any additions to the above classifications must be in writing to the Secretary Dogs NSW and will be considered by the Board of Directors, after referral to the Ethics & Welfare Working Party, on their individual merit.)
Part XIII – Code of Ethics (Latest Amendment July 2014) Page 2 of 4
9. 10.
A Member shall not breed a bitch that results in it whelping more than twice in eighteen months without the prior approval of the Board of Directors except under extenuating circumstances where application for registration of the litter may be considered by the Board of Directors.
A Member shall not breed a bitch that results in it whelping more than twice in two years without the prior written approval of a Veterinary Surgeon certifying her fitness to carry and whelp the third litter.
A Member shall not breed a bitch that results in it whelping more than six times without prior veterinary certification of fitness for further breeding and without prior approval of the Board of Directors except under extenuating circumstances where application for registration of the litter may be considered by the Board of Directors.
A member shall not conduct or permit mother/son, father/daughter or brother/sister matings. The member is fully aware that puppies, as a result of such matings, will not be registered on the Main Register, without first having gained approval for the mating from the Board of Directors, for scientifically proven welfare or veterinary reasons.
A member shall not knowingly permit the mating of any dog or bitch which is not registered on the Main Register of ANKC Ltd or with an organisation on the listing of ANKC Recognised Working Dog Associations/Kindred Bodies as being eligible for registration on the Sporting Register. (07/13)
A Member shall not knowingly permit any of that Member's pure bred dogs to be mated to a dog of a different breed, to a cross-bred dog, or to any unregistered dog of the same breed or to a dog not on the Main Register unless:-
i) such mating is for the health, welfare and/or the development of a breed or an aspect thereof,
ii) The member has obtained the prior approval of the Board of Directors.
The prohibition against crossbreeding contained in this clause shall not apply to guide and working dogs.
All members must register all litters bred by them, either alone or jointly with another. Registration of a litter must be effected within 6 months of the date of whelping. For the purposes of this clause "litter" includes all puppies there from living at the date of registration of the litter. A member shall register all puppies in a litter at the same time and on one form of application for Registration of Litter.
A Member shall include their Dogs NSW Membership Number in an advertisement placed in any form of media, or on any sign whatsoever, which advertises a dog or puppy for sale whether for payment or not. Such quotation shall be in the form "Dogs NSW Member xxxxxxxxxx". (04/14)
A Member shall not sell or otherwise transfer from that Member's care any puppy under eight (8) weeks of age. Puppies must be micro chipped and vaccinated prior to leaving that Member's care.
A Member shall ensure that all persons acquiring dogs from that Member clearly understands their responsibility for the care and welfare of the animal and that they have the time and facilities (ie adequate fences, sufficient room and proper shelter etc) to perform their obligations.
16 17.
Part XIII – Code of Ethics (Latest Amendment July 2014) Page 3 of 4
A Member must provide to all new owners of dogs sold or placed by that Member, written details of all dietary and immunisation requirements and/or appropriate publications relating to such requirements as responsible dog ownership and breed specific information.
A Member shall not:
(a) supply any dog to commercial dog wholesalers or retail pet dealers (07/14)
(b) allow a dog owned by that member to be given as a prize or donation in a contest of any kind.
(c) offer a dog for sale by auction through any form of media.
A Member shall not KNOWINGLY misrepresent the characteristics of the breed.
A member shall ensure that within 28 days of the date of sale or transfer of a dog to another person that documents, as required by the Dogs NSW Regulations Part 1, are provided to the new owner of the dog.
Upon the sale or transfer of a dog a Member shall supply the new owner with a current vaccination certificate signed by a Veterinary Surgeon evidencing that the dog has been immunised against Canine Distemper, Hepatitis, and Parvo Virus along with microchip documentation.
No dog should be sold or transferred in a state of ill health. It is a defence to any complaint against a member for contravention of this Clause if the Member proves that it was not reasonably practicable for the Member to know that the dog was in ill health at the time of sale or transfer.
Puppies can be exported at an age that is permitted under the relevant livestock import regulations of the country to which they are being imported but under no circumstances are weaned puppies younger than the age of eleven (11) weeks to be exported.
A member shall not engage in false or misleading advertising relating to the conformation, characteristics or performance of that member's dog and shall only advertise a dog's name with the inclusion of titles awarded and registered on the ANKC database at the time of lodgement of the advertisement.
A member who provides or makes available a dog for use in a film, advertisement, promotion, any media or public display must use reasonable care to ensure that:
(a) the dog is portrayed in a fashion consistent with its breed characteristics and temperament as described in the Standard for the breed and
(b) the dog is presented in a fashion that is unlikely to create a negative reaction to dogs generally or that breed in particular and that if there is any likelihood of a negative impression, this is at the same time corrected through the development of a story line that presents the dog or the breed (as appropriate) in a balanced fashion.
Part XIII – Code of Ethics (Latest Amendment July 2014) Page 4 of 4
Contact DetailsMiss Sharan Burnley
Bayview, NSW, Australia
Phone : 0499516487
Email : [email protected]


text:
I saw my Maid of Honor, Nichole, on Sunday at her brother's housewarming party. She gave me my belated birthday present (we've both forgotten the few times we've seen each other since July). In her card, she wrote that she is excited and honored to be my Maid of Honor.
Here's a little background on Nichole. We've been friends since we were 12 years old and bonded over a mutual love of NKOTB. We've gone in different paths (she in the burbs, I'm a city girl) but we've always bothered to stay connected.
Her very large (and loud) Greek family has included me in every family celebration since middle school. I have babysat almost every single one of her 20 cousins. Her and her mother are planning on throwing me my shower. I am so lucky to have her in my life.


text:
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|Also Known As:
|Doc Karman, Lawrence C Karman, Laurence Karmen, Lawrence Karman (Doc), Larry Karman, Lawrence Karmen
|Cause of Death:
|Birth Place:
Biography CLOSE THE FULL BIOGRAPHY
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text:
Written by Harry Lorayne
Work of Harry Lorayne
160 pages (Hardcover),
published by D. Robbins & Co., Inc.
Illustrated with drawings by William A. Morales.
Language: English
(56 entries)
|Comments & References
|foreword\n\nharry lorayne 1967 Harry Lorayne
|the "kick" double-lift\n\nharry lorayne\nthe double lift\ncliff green\nspread-off double lift\nharry lorayne\nreverse kick lift\nfrank simon 1967 Harry Lorayne
|The "Kick" Double-Lift
|basic get-ready\nnot so good\n unknown 1967 Unknown
|Basic Get-Ready
|double-lift gag\nsucker presentation\nharry lorayne 1967 Harry Lorayne
|Double-Lift Gag
|double put-down\nwith deck in hand\nharry lorayne 1967 Harry Lorayne
|Double Put-Down
|double trouble\ntwo cards change into selections\nharry lorayne 1967 Harry Lorayne
|Double Trouble
|caught!\n\nharry lorayne 1967 Harry Lorayne
|spellbinder\nany selection is spelled to\nharry lorayne 1967 Harry Lorayne
|the flip-over locator\nthree selections\nharry lorayne\nspread control (flip-over)\nharry lorayne 1967 Harry Lorayne
|The Flip-Over Locator
|flip-over\n\nharry lorayne 1967 Harry Lorayne
|foursome\nfour of a kind to free selection is produced\nharry lorayne\npokerface\nallan ackerman\nglasnost\npeter duffie\nfoursome fourall\nharry lorayne\ncall your bluff\ntony cabral 1967 Harry Lorayne
|peek key card placement\nkey placed next to peeked at card\n unknown 1967 Unknown
|Peek Key Card Placement
|braue addition and switch\n\nfrederick braue 1967 Frederick Braue
|Braue Addition and Switch
|the magic step\na card changes repeatedly after a weird cutting procedure, at the end two cards change places\nharry lorayne 1967 Harry Lorayne
|The Magic Step
|slide-down switch\nsliding a card down with forefinger when deck is in openly stepped condition in the hands\n unknown 1967 Unknown
|Slide-Down Switch
|new-fangled color change\nfan is brushed over pile in other hand\nharry lorayne 1967 Harry Lorayne
|New-Fangled Color Change
|as a double color change\n\nharry lorayne 1967 Harry Lorayne
|As a Double Color Change
|outrageous revelation\ndeck held under table for a second, selection appears on deck face up\nharry lorayne 1967 Harry Lorayne
|Outrageous Revelation
|outrageous revelation #2\ncard replaced under table in secretly reversed deck\nharry lorayne 1967 Harry Lorayne
|Outrageous Revelation #2
|that burns me up!\nlit cigarette vanishes and reappears in pocket\nharry lorayne 1967 Harry Lorayne
|That Burns Me Up!
|false transfer\n\n unknown 1967 Unknown
|False Transfer
|the card pyramid\nmathematical layout of spot cards, end result is predicted, for waters credit see reference\nharry lorayne\nthomas alan waters\nmathematically inclined\nl. vosburgh lyons\nthomas alan waters\nbabel\nkarl fulves 1967 Harry Lorayne, Thomas Alan Waters
|The Card Pyramid
|out of this world memory\npresentation for ootw as memory stunt\nharry lorayne 1967 Harry Lorayne
|Out of this World Memory
|double billemma\nborrowed bill is torn, one half travels somewhere, then bill is restored\nharry lorayne 1967 Harry Lorayne
|Double Billemma
|the indicator\nprocedure to set up a four of a kind for spelling from a shuffled deck\nharry lorayne\neasy indicator\nharry lorayne\ncard selection\npeter duffie 1967 Harry Lorayne
|The Indicator
|oh, those aces!\naces start in lap, sucker dealing procedure\nharry lorayne 1967 Harry Lorayne
|Oh, those Aces!
|ten card poker deal\nmultiple phase template routine\nharry lorayne\nthe ten card poker killer\njohn f. mendoza\nten card poker deal\nharry lorayne\nchristian scherer\nten card poker deal\nharry lorayne 1967 Harry Lorayne
|Ten Card Poker Deal
|slip shuffle\nretaining bottom card\n unknown 1967 Unknown
|Slip Shuffle
|cointrol\nborrowed penny changes to quarter, quarter vanishes, reappears, changes back to penny\nharry lorayne 1967 Harry Lorayne
|propelled sleeve switch\n\n unknown 1967 Unknown
|Propelled Sleeve Switch
|pumpkin seed vanish\n\n unknown 1967 Unknown
|Pumpkin Seed Vanish
|the royal lovers\nfour of a kind appear one by one between sandwich cards\nr. sid spocane ii\nthe st. nicholas aces\nkarl fulves\nbabel\nkarl fulves\nroyal mayo\ndavid solomon\nfiveplay\ntony cabral 1967 R. Sid Spocane II
|The Royal Lovers
|faro blockbuster\n3&3, as climax the cards are reversed in deck, some faro shuffles, then deck is separated in red and blacks\nharry lorayne 1967 Harry Lorayne
|Faro Blockbuster
|six card follow the leader phase\n\nharry lorayne 1967 Harry Lorayne
|Six Card Follow the Leader Phase
|oil and water phase\n3&3\nherb zarrow 1967 Herb Zarrow
|Oil and Water Phase
|one-eyed jack sandwich sequel\ntwo indifferent cards between red aces become black aces\nharry lorayne 1967 Harry Lorayne
|One-Eyed Jack Sandwich Sequel
|double pinky pull down\nsecuring a break above two bottom cards\nharry lorayne 1967 Harry Lorayne
|Double Pinky Pull Down
|modernized slop shuffle\n\njohn benzais 1967 John Benzais
|Modernized Slop Shuffle
|mental photography\nblank deck, spectator thinks of any card and goes through some dealing procedure, thought of card appears, all others blank, card index\nharry lorayne\nbob hummer\nmake your mind a blank\ndoug edwards 1967 Harry Lorayne, Bob Hummer
|Mental Photography
|self-index\ndescribed for the forty number cards\nharry lorayne 1967 Harry Lorayne
|1-2-3 aces\ndifferent cutting sequences to produce the aces\nharry lorayne\n4-5-6 aces\nrichard kaufman 1967 Harry Lorayne
|1-2-3 Aces
|braue reversal variation\nreversed cards end up below a cover card\nharry lorayne\nfrederick braue 1967 Harry Lorayne, Frederick Braue
|Braue Reversal Variation
|about faces\ntwo cards, two keys\njerry lubin\nharry lorayne 1967 Jerry Lubin, Harry Lorayne
|About Faces
|favorite aces and kings\naces are spelled to, then kings are found as well, faro\nharry lorayne\naces only - with kings\nharry lorayne\nstranger card faro location\nharry lorayne 1967 Harry Lorayne
|Favorite Aces and Kings
|stabbed in the pack\ncard really thrown in deck\nharry lorayne\nstabbed in the pack\njohn benzais\nharry lorayne\none in a million\neric mason\nlaterally stabbed\ntom gagnon\ntossed in the deck\ncamilo vázquez\nstabbed in the pack\nharry lorayne\nshot in the pack\ntom gagnon 1967 Harry Lorayne
|Stabbed in the Pack
|bass ackwards slip-cut\nbottom card to center for tabled stab force\nharry lorayne 1967 Harry Lorayne
|Bass Ackwards Slip-Cut
|the strip-out sleight\n\nharry lorayne\ndr. jacob daley\nbevel multiple shift\ndr. jacob daley 1967 Harry Lorayne, Dr. Jacob Daley
|The Strip-Out Sleight
|vice triumphant\nfour jacks vanish from deck, reappear in pocket, story presentation\nharry lorayne 1967 Harry Lorayne
|Vice Triumphant
|trampoline\nflourish flip over on tabled deck\nharry lorayne\ntrampoline, the second\nharry lorayne\nthe (n)eye(n) popper\nharry lorayne 1967 Harry Lorayne
|flying aces\naces fly out of deck one by one\nharry lorayne 1967 Harry Lorayne
|Flying Aces
|flying ace move\nsecond card from top\nharry lorayne 1967 Harry Lorayne
|Flying Ace Move
|the choice is yours\nspectator choses one of three piles, bottom highest card wins ("bankers and brokers")\nart johnston 1967 Art Johnston
|The Choice is Yours
|pile-to-pile transfer\nwhile turning them over, unsophisticated version of "given the slip"\n unknown\ngiven the slip\ndai vernon 1967 Unknown
|Pile-to-Pile Transfer
|to change a card\non tabled pile\nharry lorayne 1967 Harry Lorayne
|To Change a Card
|deal & duck\neight cards removed below the table by performer and spectator, packet used to find aces via deal & duck\nbill simon\nharry lorayne\na much better chance\nharry lorayne 1967 Bill Simon, Harry Lorayne
|Deal & Duck
|last word\n\nharry lorayne 1967 Harry Lorayne
|Last Word


text:
Home Learning Menu
Year 1
Year 2
Please see below for a selection of websites chosen by Motcombe to support learning at home.
E-Safety For Children
CEOP (Child Exploitation and Online Protection) produces information to help teach children important concepts and actions to keep themselves safe online.
Watch Kim and Sam's Adventure >
E-Safety Help For Parents
• Know what your children are doing online and who they are talking to.
• Ask them to teach you to use any applications you have never used.
• Keeping the computer in a family room means that you can share your child's online experience – and that they are less likely to act inappropriately (i.e. via webcam).
• Help your children to understand that they should never give out personal details to online friends — personal information includes their messenger ID, email address, mobile number and any pictures of themselves, their family or friends.
• If your child publishes a picture or video online, anyone can change it or share it. Remind them that anyone may be looking at their images and one day a future employer could!
• If your child receives spam/junk email & texts, remind them never to believe them, reply to them or use them. It's not a good idea for your child to open files that are from people they don't know. They won't know what they contain — it could be a virus, or worse — an inappropriate image or film.
• Help your child to understand that people don't always tell the truth online and therefore it's better to keep online friends online. They should never meet up with any strangers without an adult they trust.
• Always keep communication open for a child to know that it's never too late to tell someone if something makes them feel uncomfortable. Teach young people how to block someone online and how to report them if they feel uncomfortable.


text:
Name: Sterling Sharpe
Team: Green Bay Packers
Positions: Wide receiver, Rocket man
Value of card: One background from an Atari football video game
Key 1989 stat: 134 times impersonating Elton John
Sterling Shatner sings: She packed my pads last night, preflight. Zero hour, nine a.m. And I'm gonna be high as Brett Favre by then.
I miss the Earth so much. I miss my wife. It's lonely out in Green Bay, on such a timeless flight. And I think it's gonna be a long, long time till a touchdown brings me round again to find I'm not the man they think I am at home. Oh no, no, no, I'm a rocket man.
Rocket man, burning out his fuse up here alone.
Lambeau ain't the kind of place to raise your kids. In fact it's cold as hell — and there's no one there to raise them if you did. And all this science, I don't understand. It's just my job one day a week. A rocket man, a rocket man. And I think it's gonna be a long, long time...
Sterling Sharpe, 1990 Score (Football Friday No. 15)
at 11:04 PM
Labels: 1990 Score, Cheesy background, Football, Hall of Famer, Music, Packers, Sterling Sharpe
1 comment:
Subscribe to: Post Comments (Atom)


text:
Sunday, November 16, 2008
Menu Plan Monday
10 comments:
- Terri Steffes said...
I wish I could listen to you! I don't see birthday cake on your list... since it is my birthday today, I totally expected to see it. (JK) Hope your interview is fabulous!
- November 17, 2008 at 5:19 AM
- heidi said...
Good luck on the radio show!
That Lemon Garlic Pasta is one of our favorites, here.
Stole the roll recipe for TONIGHT (nothing like plannign ahead LOL).
- November 17, 2008 at 8:20 AM
- Unknown said...
I am so enjoying your blog and your sense of humor!
- November 17, 2008 at 11:42 AM
- Manic Monday said...
hmmmm... menu plan monday. a great idea. thanks!
- November 17, 2008 at 11:52 AM
- Katie Gregg said...
I like how many tasty vegetarian meals you included!
- November 17, 2008 at 12:45 PM
- Lynn said...
I made the buttery bread machine rolls for dinner tonight. It's going to take an extreme amount of personal restraint to not eat them all later on tonight!!
- November 17, 2008 at 5:23 PM
I notice a lot of lemon things, but in your grocery shopping I didn't see any lemons. Do you have a hidden stash of lemons somewhere?
- November 18, 2008 at 7:01 AM
- Gayle said...
No, no stash of lemons but I have a bottle of lemon juice that I bought last week.
- November 18, 2008 at 7:15 AM
the link to the lemon muffins goes to creamy tomato soup instead. What is the correct muffin link?
- November 18, 2008 at 5:57 PM
- Gayle said...
The muffin link should be fixed now. Sorry about that guys. It looks like a good one.
- November 18, 2008 at 7:08 PM


text:
There's no doubt that all businesses are facing tough economic conditions these days. Fortunately, it's not those conditions that determine the future, but how our companies respond to those conditions.
When the economy tightens – as it always does at times – the first action of many companies is to cut costs. Too often, marketing and sales is one of the first cuts. On the surface, this seems like a wise decision. However, cutting sales and marketing may prove detrimental to your company as a whole.
This is our sixth recession since 1970.
Our country made it through recessions in 1970, 1974-75, 1981-82, 1990-91, and as recent as 2001. Think about this for a moment. Was your company in business during any of these recessions? Did you stay in business? Did you keep your job and avoid ending up broke and on the streets? You probably answered yes to all three questions. Are you still in business today? If so, let's take a collective deep breath and realize we've been here before and we've made it through.
In tough economic times, what does your company need most?
If you're like most, you need sales revenue and customers. Ask yourself and your team how reducing or cutting the marketing budget (that brings revenue and customers) is a prudent and smart thing to do for your company. Keep your marketing budget the same or increase it, and make sure your marketing investments are delivering what you need most – sales revenue and customers.
Various studies on the impact of marketing spending during various recessions all point to the same conclusion: "Companies who maintain or increase their marketing budgets during recessions experience sales growth two to three times higher than those who reduce or cut their budget. And not just during the recessionary period but for up to two years after."
Don't be afraid to go forward with your marketing and maintain a quiet and calm confidence that in times like these, many of your less informed competitors will reduce their marketing budgets. In doing so, they'll create more space for your company to capture and increase mindshare and build market share. Do everything you can to make sure your marketing and tradeshow investments are positioned for maximum success. It's important to get involved, use the ideas that make sense for you and keep your company and our economy strong and growing.
SOURCE: Jefferson Davis, Competitive Edge


text:
Things are going well in my challenge so far.
I've played about 15k hands already, and the bike's odometer is at 62km. I also dropped a .9KG already.
So, yeah:
I'm feeling better already, and I'm settling into a good routine.
Also, today was awesome because the first 2 episodes from the new season of Weeds got leaked a month early. The show is awesome and the season premiere was hilarious. Kevin Nealon is awesome on that show. Check it out if you havn't already. A taste:


text:
Amanda's honeymoon style
Categories Honeymoons
Now that we've got tropical drinks, crisp blue water, and swimsuits on the mind (thanks to Amanda's French Polynesia honeymoon), we figured we'd shop around to steal some of her style. Summer is just right around the corner anyways, so we're totes going to stock up on some of these getaway ready fashion beauties…
Social Love
@sashbuzz on Apr 17, 2013
Amanda's honeymoon style http://t.co/j8yerh0SCs
Katie O'Keefe on Apr 17, 2013
I've been eyeing that Anthropologie suit for some time - love it!
Wedding Planner London - Soirée de Luxe on Apr 18, 2013
That print one piece is fabulous - I want!!!
Scarlett James on May 21, 2015
Nice Blog! Honeymoon style depend upon the culture.


text:
Brazilian Fistball player Rejane Sinhori is The World Games Athlete of the Month in November 2017! Congratulations!
The defensive player Sinhori produced an exceptional performance at the IFA 2017 Fistball Women's World Cup at the end of October in Curitiba (Brazil), where the home country topped the podium. The 32-year-old has been performing at a very high level for many years. Amongst many other successes, she is World Cup winner from 2016 and 2017, was Pan-American Champion in 2015 and was World Champion in 2010 and 2016 - and now, our Athlete of the Month!


text:
I have a problem. Lately I've been thinking, I haven't come very far from where I was when I was 9 years old.
When I was nine, I remember laying to bed every night and praying, "Lord, I haven't sinned today."
And I remember truthfully thinking about what I had or had not done that day. It's kind of funny, really. For I know I DID in fact sin–every single day. But I just didn't come clean about it with myself. You know when you are lying to yourself as a child that that trait will follow you on into adulthood.
So…is my current problem about me confessing I haven't sinned every day? Nope.
My current problem is this: I'm a productivity junkie.
I've taken making moments count and made it an idol. Every minute of every day, I think I need to be busy doing something. It's almost like I think someone is taking note of my time and keeping a ledger to account for my life each and every day.
Isn't that crazy?
I love time management. It is something I think about often–not to the point of Cheaper by the Dozen's Frank Gilbreth, Sr, but often enough that I am continually thinking about how I can multi-task each second–a productive second makes a happy Holly. If I've ever done work for you before, you can rely on me packing the moments with work, so that every hour counts.
I've taken "I can" into the realm of "I should"–therein lies the problem.
To be completely honest with you, I have laid this heavy burden on myself. I have an expectation to excel–to show that how I spent my day was valuable and worthy.
The problem is this.
It's not much different than that prayer I prayed every night, as a nine year old girl. I'm still praying, "Lord, today I did not…" But now I'm adding that I did not waste time.
I did every bit of work I could fit into the day. And I know…I KNOW!…that the Lord is not keeping record of my productivity. In fact, NO ONE is. It is just me.
Here's something I need to come clean about today with myself…I don't have to be productive to matter.
Part of that issue is simply this: I have not been without constant work (except for two weeks of vacation last year) for two and a half years–the other vacations, I actually brought my work with me.
I am a workaholic.
When we do take a weekend trip or even on our vacation last summer, it takes me a couple of days to just let everything fade into the background. I have become that driven and uptight. I have hobbies and other things I like to do. But sometimes I'm too tired and spent to even enjoy them.
The glorious thing, though…and yes, I say glorious! Is that I have ONE person's email in my web design work file right now. And she has a list of small things. After that? Well…after that I am taking a complete break from web design through the end of the summer.
Then I will re-evaluate.
God's timing for this lull in web work is not coincidental.
He knows how spent I am. He has put His hand in the way, so that I will truly stop working for awhile. He also knows that my dear administrative partner Beth is about to have brain surgery again. (Please pray for her, as she faces surgery next week. Please pray especially for her family.) She is my right arm, my dear friend and prayer partner.
There are so many things I want to make count in my life–investments into my marriage, my children, friends and family, neighbors and all those whom God will send my way.
But web work? Well, it is a means to an end for the most part. I love all things creative– so very much. And my family has truly needed me to work in this season (In fact I also have been doing a spring/summer scoring job for state testing, writing and reading tests. I am part time administrative assistant to this lovely and awesome lady. Also I assist another godly guy at this cool site in a very part time way.)
It is wonderful how God has sent SO MANY wonderful ways I could serve and help my family–at the same time!
But I'm feeling that I need to hit the brakes work-wise on everything but the last two people for the summer.
It might hurt, as we cinch up our belts a bit.
I may start feeling like I'm lazy and not contributing to our family.
But I must. For there is something the Lord has shown me over and over and over…when I am still, He is speaking to me, Words of Life.
And I don't want to miss Jesus! Not for anything.
What about you?


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As usual this is being peddled to the public as something more convenient and secure than the conventional system. I'm glad No2ID are on to this.
Wednesday, 13 February 2008
New Child Databse
Posted by Ben Emlyn-Jones at 14:52
3 comments:
- Bev said...
Glad to hear that you have already seen this.
people need to be informed about this half-baked scheme as soon as possible!
- 13 February 2008 at 22:19
- Ben Emlyn-Jones said...
Yes they do! I'm glad to see that there's a backlash already starting. This is the ID agenda again, opening a new attack on another front.
- 14 February 2008 at 17:08
Surely, the guy is totally just.
download game | games full download | best world games | download game pc | download full games
- 27 November 2011 at 21:07
Subscribe to: Post Comments (Atom)


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Sport at Royal HollowayPosted: January 27, 2017 Filed under: Interview Topic | Tags: 1960s, bedford college, hockey, royal holloway college, societies, sport 1 Comment
As an avid hockey player, having been both President and Ladies' Captain of the Hockey Club, and having co-founded a Rounder's Club on campus I have an invested interest in how different sports clubs came into existence at the university. I am interested in interviewing Royal Holloway Alumni on their experiences of extra- curricular activities, with a focus on sport, at university and how this impacted students' studies.
I know from previous research that there was once a swimming pool in Jane Holloway Hall that was closed due to storm damage and would be interesting to see how much the pool was in use when it was open.
Looking at the 1960s, and when the university became co-educational, this is the perfect time to look into how sports clubs, that use to be exclusive to women, dealt with the introduction of men and whether the clubs became mixed sex or if they remained segregated.
The project would also be extremely useful on a personal level as myself and the current Hockey Club president are looking into creating a history, using the archives, of the club which we have reason to believe is the oldest university Hockey club in the country.


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Who's your Sugar Daddy?
February 18, 2017
The eccentric old-timers seen wandering the sidewalks of Miami's Ocean Drive tied together with Jorge's curious interest in the Mexican holiday, Dia de los Muertos, stand as joint inspiration to create the character that is Sugar Daddy.
View products from Jorge's collection here


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"Most importantly, I like the person that lives inside my face."
I was born with a rare craniofacial condition called Treacher Collins, which I inherited from my dad and my grandmother. The facial bones and tissues are underdeveloped, and in my case, I was born without ears, cheekbones, and a severe cleft palate. In addition to wearing a hearing aid and taking speech therapy, I've had thirty surgeries, some of which were reconstructive, and some for unrelated health problems.
There's aspects of Treacher Collins that I struggle with, because although I'm proud to look different, having a craniofacial condition means that people ask a lot of blunt questions, often when I least expect it. "What's wrong with your face?" strangers will ask. The honest answer is that sometimes the scar tissue from past surgeries cause pain when I least expect it, or my hearing aid gives me headaches some days. That's not the answer they're looking for. But I can confidently say I like the way my face looks. I like my eyes, big and downturned, bracketed with their dark shadows underneath. I like my new apple round and pink cheekbones. And I love my perennial smile. I like looking in the mirror or at pictures of myself and finding features that I see in the people I love.
Most importantly, I like the person that lives inside my face.
I'm only twenty three, and I'm pleased to say my life has been a nonstop adventure. I've been evacuated from a hospital hours after surgery because of Hurricane Sandy. I've made countless friends on pediatric wards, the Ronald McDonald House in Wisconsin, and most importantly, in my hometown, Albany, New York. This past year, I finished writing my first novel, graduated from University at Albany with a bachelor's degree in psychology, and became a member of the Albany Tulip Court, where I serve as an ambassador to my city, and work with four other girls to promote literacy and volunteer in the community.
If I could give any children with craniofacial conditions advice, it would be this: Put yourself out there. You will come into your own the more you try new things, and you will find so many people that will love you and guide you, and eventually you'll find yourself compelled to love and guide in turn. In some ways, people's eyes will always follow you. Use it to pursue your dreams, and help others find theirs. Find others who have your condition and lean on them for support. I've relied on my dad and grandma for their resilience and experience with our shared condition and it is invaluable. Your condition can help you forge a powerful connection to the world, and to yourself.
With great affection,
Megan Morrill
Do you have a story to be told?
If you or a family member have personal experience of living with a facial difference, we would love to hear your story to help us fight for facial equality throughout the world. We are excited to hear your story whether you would like it to be shared on social media, or just keep it anonymous.
The First Steps:
First just complete the form above, and it will be reviewed by our Communications Director. She will contact you about your story to discuss how you would like it to be shared. If you have any questions about sharing your story, please e-mail us at firstname.lastname@example.com.
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We will use your story for social media campaigns to celebrate differences, raise awareness, and fight for facial equality throughout the world. We will also use your story in presentations at schools, and businesses to show how they can improve. Your story will only be used for FACES, and will not be shared with other charities or third parties.


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Black Mountain Academy is the ideal setting for young men to learn, grow, and excel in a quiet, home-like environment. Our specialized boarding school for boys becomes a safe place for them to practice and reinforce the skills they need to return home, engage in jobs, and pursue higher education. The Black Mountain Academy staff is equipped to support residential life in a way that enriches the student's educational and therapeutic goals. Our clinical and academic teams work collaboratively to plan in the moment experiences aimed at reinforcing social communication skills, self-awareness, healthy lifestyle choices, and self-reliance. Our caring team seamlessly integrates clinical and individualized goals for every student into daily living and weekend experiences. Residential Life Goals:
- Implementing personal goals with the support of staff
- Practicing friendship
- Utilizing executive function and life skills in the daily routine
- Implementing self-care through good hygiene, organization, and diet
- Relaxing and having fun
- Creating space to recuperate from the school day
- Pursuing personal interests


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Tue 01, Mar 2016
Download your copy of the 2013 editions of the ANZCJ journals
Thu 25, Feb 2016
A recent study, by Curtin University's School of Physiotherapy and Exercise Science found that sit-ups could be bad for the pelvic floor.
Wed 17, Feb 2016
Women go to great lengths to keep their hearts and bodies in shape, but the one critical area of their body responsible for keeping them continent – particularly as they become older - is often overlooked and, in many cases, sabotaged
Tue 16, Feb 2016
Older people in hospital is a new web-based resource providing clinicians with evidence based information and simple strategies to minimise the risk of functional decline for older people in hospital.
Wed 10, Feb 2016
The next edition of Bridge, out in two weeks, features some remarkable stories about some inspiring people.
Thu 28, Jan 2016
A common concern for parents of first-timers is their ability to negotiate the school toilets.
Wed 13, Jan 2016
For some children, the thought of an overnight sleepover can be the cause of much anxiety. Child psychologist Chris Hardwick offers some practical suggestions for parents.
Thu 17, Dec 2015
Kate Winslet includes herself in the one in three statistic, recently announcing it somewhat publicly last month on the Graham Norton Show.
Wed 09, Dec 2015
Recipients of the Australian Bladder Foundation grants were announced at last month's AGM.
Thu 29, Oct 2015
A recent study has found an association between increased body mass index (BMI) and the incidence of prolapse in women one year after childbirth.
Wed 21, Oct 2015
A recent US study suggests overactive bladder increases the risk of falls in the older population by as much as 40 per cent.
Wed 30, Sep 2015
Just one hour of physical activity per week can significantly reduce the likelihood of nocturia in men, according to a recent Loyola University study.
Wed 19, Aug 2015
Parents of children with disabilities make up a large proportion of the 2.7 million unpaid carers across Australia.
Wed 17, Jun 2015
A study last year at Loyola University Chicago has found that bacteria present in urine may be the cause of urge urinary incontinence.
Tue 31, Mar 2015
Listen to a special podcast on children and incontinence featuring Dr Janet Chase.
Wed 04, Mar 2015
When stories about teachers punishing children for taking toilet breaks in class time come up in the news media, it's an opportunity for teachers and school communities to be reminded of the critical role they play in shaping children's bladder and bowel health, as well as their mental health.
Thu 05, Feb 2015
Lifelong behaviours and attitudes begin early, which is why so many schools have signed up for Toilet Tactics. Has your school?
Thu 08, Jan 2015
We often hear recommendations about how much water we should drink. But there's just one simple rule that all health authorities agree on; drink to satisfy your thirst – no more, no less.
Thu 06, Nov 2014
A diagnosis of prostate cancer may be an opportunity for men to invest in their long-term health. Men's specialist physiotherapist Jo Milios explains.
Tue 23, Sep 2014
More than one third of Australian women may be affected by some form of urinary incontinence (UI). Participate in this new online module and refresh your understanding of the best assessment methods and first-line treatment strategies for the management of this condition.
Thu 04, Sep 2014
With RUOK Week (Sept 8 – 12) upon us, young women need to be made aware that incontinence puts them at a higher risk of depression.
Thu 21, Aug 2014
The Continence Foundation of Australia echoes the messages about confidence being promoted by Jean Hailes during Women's Health Week next week.
Thu 07, Aug 2014
A Radio National program hosted by Natasha Mitchell earlier this week brought the issue of bedwetting among adolescents into the open.
Tue 05, Aug 2014
More and more research is showing that incontinence and osteoporosis are closely linked, which has significant lifestyle implications for women approaching middle age and older.
Thu 24, Jul 2014
If your child rush to the toilet as soon as they get home from school, perhaps their school toilet experience isn't a particularly good one.
Wed 18, Jun 2014
Out-dated attitudes, such as accepting incontinence after childbirth as normal, are alive and well, even among the most educated in the community.
Tue 10, Jun 2014
The consequences of ignoring the pelvic floor when exercising can be traumatic and dramatic, as Mildura continence nurse Katherine Modoo discovered.
Thu 24, Apr 2014
Even though asthma is a condition affecting the respiratory system, it often contributes to the risk of bladder leakage.
Tue 18, Mar 2014
Are you an adult with an overactive bladder? An international study trialling a new drug is recruiting now.
Thu 13, Mar 2014
A Sydney physiotherapist takes a critical look at the conventional pelvic floor training regime for men post-prostate surgery.
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Cathepsin K is an extremely potent collagenase as well as the predominant papain-like cysteine protease expressed in osteoclasts. preclinical studies and so are in scientific trials at different stages of advancement presently. The introduction of the inhibitors and primary results from the scientific trials revealed complications and lessons regarding the specificity Angpt2 from the substances and their tissues targeting. Within this review we are going to briefly summarize the annals of cathepsin K analysis and can discuss the existing advancement of cathepsin K inhibitors as book anti-resorptives for the treating osteoporosis. We may also discuss potential off-target ramifications of cathepsin K inhibition and choice applications of cathepsin K inhibitors in joint disease atherosclerosis blood circulation pressure legislation obesity and cancers. and screening have already been exploited for the introduction of energetic site-directed inhibitors. Many initiatives targeted the cysteine thiol moiety of AZD8186 cathepsin K with reactive electrophile "warheads" to be able to reversibly inhibit or irreversibly inactivate its proteolytic activity (for review: [61]). 4.1 Criteria for the pharmacologically relevant cathepsin K inhibitor applicant Ideally cathepsin K inhibitors ought to be of low molecular fat exhibiting minimal peptide personality bind reversibly and highly selectively without affecting various other main cysteine cathepsin family specially the closely related cathepsins L S and V (a minimum of a 100-fold higher affinity i.e. lower Ki or IC50- beliefs). The main challenge from the inhibitor style also requires regular drug-like properties such as for example dental bioavailability with high pharmacological information (high membrane permeability longer plasma half-lives gradual elimination prices no or low toxicity) for acute and chronic use. In the case of cathepsin K inhibitors have to be delivered into the lysosomes and the resorption lacuna of osteoclasts (osteoporosis therapy) and to synovial fibroblasts for any potential rheumatoid arthritis therapy. Briefly early cathepsin K inhibitors were irreversibly acting compounds which inferred predictable side effects if used chronically (antigenic and immunologic complications by generating immunogic haptens from covalently bound inhibitor-cathepsin adducts significant off-target inhibition). Though pharmacologically not AZD8186 useful these compounds were and are important study tools for the characterization of individual cathepsins. Good examples are: E-64 and related expoxysuccinyl derivatives ketones diacyl-bis hydrazides and vinyl sulfones [52 56 53 Subsequently most development efforts were and are concentrated on the synthesis of reversible inhibitors which include peptidyl aldehydes amides α-keto hetero-cycles aliphatic ketones and nitriles (for review observe [59]). As cathepsin K AZD8186 and most additional cathepsins are lysosomal enzymes inhibitors were designed to contain lipophilic AZD8186 and fundamental moieties to allow cell permeability and lysosomotropism. Once protonated within the acidic subcellular organelles the inhibitors become membrane impermeable [62 61 However their increased build up in acidic lysosome/endosome may result in off-target inhibition of cysteine proteases other than cathepsin K. Therefore the strategy shifted to the design of nonbasic inhibitors which still keep their strength and selectivity against specific cathepsins in addition to their efficiency in cell-based assays [63 64 nonbasic cathepsin K inhibitors seem to be safer because they protect their selectivity over various other related-cysteine cathepsins without changing their efficiency. No anti-cathepsin K medication continues to be FDA approved. Nevertheless many inhibitors of cathepsin K are in various phases of clinical advancement for AZD8186 osteoporosis presently. The interested audience can be referred to the next recent evaluations [55 65 Inhibitors specifically balicatib in Stage II (Novartis); relicatib in Stage I (GlaxoSmithKline) odanacatib in Stage III (Merck Frosst/Celera) in addition to MIV-701/710 in Stage I/pre-clinical (Medivir Abdominal) and an inhibitor from Amura Pharmaceuticals in pre-clinical evaluation is AZD8186 going to be referred to in greater detail (Desk 1). This list isn't exhaustive in support of comprises more complex inhibitors. Desk 1 Book inhibitors of cathepsin K in pre/medical advancement 4.2 Balicatib Balicatib (AAE581) may be the innovative cathepsin K inhibitor within the Novartis pipeline. Balicatib can be a simple peptidic.
Category: AXOR12 Receptor
Hepatic normal and Compact disc1d-restricted killer T cell populations are heterogeneous.
Hepatic normal and Compact disc1d-restricted killer T cell populations are heterogeneous. including matched up ex girlfriend or boyfriend vivo versus in vitro extended IHL showed detectable non-invariant Compact disc1d-reactivity in significant proportions of Vigabatrin HCV-positive livers and significant fractions of HCV-negative livers. Nevertheless α-galactosylceramide-reactive iNKT seldom were detected just fairly. Liver Compact disc1d-restricted IHL created IFNγ variable degrees of IL-10 and humble degrees of Th2 cytokines IL-4 and IL-13 ex girlfriend or boyfriend vivo. Within a book FACS assay a significant small percentage (10-20%) of hepatic T cells quickly created IFNγ and up-regulated activation marker Compact disc69 in response to Compact disc1d. As previously just proven with murine iNKT non-invariant individual CD1d-specific replies had been augmented Vigabatrin by IL-12. Oddly enough Compact disc1d was also discovered selectively portrayed on the top of hepatocytes in CHC however not those CHC topics with background of alcohol use or solved CHC. As opposed to hepatic iNKT non-invariant IFNγ-making Type 2 Compact disc1d-reactive NKT cells are generally discovered in CHC as well as cognate ligand Compact disc1d implicating them in CHC liver organ harm. lipid in PBC (27 34 35 Although functionally comparable to iNKT 'non-invariant' Compact disc1d-restricted T cells ('Type 2 NKT') make use of diverse TCR. Certainly identification of up-regulated Compact disc1d by murine Vγ4+ T cells causes viral myocarditis an autoimmune of usually effective picornaviral immunity (40 41 Murine iNKT could cause severe hepatitis (42-45). Nevertheless αGalCer suppresses viral replication and phenotypically NKT are turned on in HBV versions (46 47 Compact disc1d is portrayed on human liver organ mononuclear cells and unlike various other CD1s Compact disc1d-reactivity is saturated in uninvolved liver organ of wedge biopsies (22). Using operative specimens we Vigabatrin have now survey low level iNKT activity but a higher proportions of hepatic Compact disc1d-reactivity showed from CHC topics and from a percentage of controls.. Compact disc1d recognition by IHL from HCV± donors produced prototype inflammatory IFNγ adjustable detectable and IL-10 Th2 cytokines. Interestingly hepatocyte surface area CD1d was also raised specifically in CHC. Results claim that citizen hepatic non-invariant Compact disc1d-restricted NKT react to elevated hepatocyte Compact disc1d in CHC with possibly pathologic consequences. Materials & Methods Research Subjects Discarded liver organ tissues surplus to pathology had been obtained from sufferers with ESLD/liver organ failure because of amyloidosis autoimmune or viral hepatitis principal sclerosing cholangitis and/or alcoholic beverages abuse (Desk 1). Cirrhotic transplant receiver ESLD/FHF topics shown this demographic (21-62 yo ; mainly US Veteran men late Rabbit Polyclonal to CaMK2-beta/gamma/delta. 40s-middle-50s). Non-ESLD control liver organ samples had been from similar topics with principal HCC or metastatic (mainly noted or presumed colonic) tumors extracted from Cooperative Individual Tissues Network or Country wide Disease Reference Interchange. Studies had been accepted by the institutional Committee on Clinical Investigations. Desk 1 Subject Position and Comparative Vigabatrin Hepatic IFNγ Creation versus after extension Compact disc1d-reactivity (mostly IFNγ) is normally detectable in nearly all human liver organ biopsy examples assayed after extension from wedge biopsy lymphocytes assayed from healthful liver organ transplant donors and from uninvolved tissues of tumor resections (19 21 22 To check the validity of the results IHL from a variety of donors had been directly tested in comparison to replies of similar liver organ samples after extension Vigabatrin (Amount 1A B). A variety of humble to solid (>100pg.mL?1) net Compact disc1d-specific (Compact disc1d+-Mock C1R) IFNγ replies were detected from directly were much like amounts obtained with expanded IHL although needlessly to say mostly significantly less than from anonymous leukopak-derived pure iNKT cell series handles (19 21 22 assayed in the same cell quantities (Amount 1A-E). Amount 1 Evaluation of hepatic Compact disc1d-reactive T cells assayed straight versus after extension: cytokine profile of hepatic Compact disc1d-reactive T cells in comparison to replies obtained from matched up liver organ samples after extension expanded IHL immediate assayed material included clear Compact disc1d reactivity (Amount 1C-E). We analyzed cytokines regarded as additional.
The first stage of human immunodeficiency virus type 1 (HIV-1) infection
The first stage of human immunodeficiency virus type 1 (HIV-1) infection involves the fusion of viral and Rabbit polyclonal to ZNF22. sponsor cellular membranes mediated by viral envelope glycoprotein gp120. cytotoxicity and effectiveness both only and in combination with additional antiviral compounds against HIV-1. HNG-156 inhibited a panel of 16 subtype B and C isolates of HIV-1 inside a single-round illness assay. Inhibition of cell illness by replication-competent medical isolates of HIV-1 was also observed with HNG-156. We found that HNG-156 experienced a greater than predicted effect when combined with several other access inhibitors or the reverse transcriptase inhibitor tenofovir. Overall we find that HNG-156 is definitely noncytotoxic has a broad inhibition profile and provides a positive combination with several inhibitors of the HIV-1 existence cycle. These results support the pursuit of effectiveness and toxicity analyses in more advanced cell and animal models to develop peptide triazole family inhibitors of HIV-1 into antagonists of HIV-1 illness. Intro The global spread of human being immunodeficiency disease type 1 (HIV-1) with an annual incidence of 2.6 million cases in 2009 2009 continues to be a serious public health problem and a daunting concern for the discovery of interventions that can be effective across all human being cultures. Among the populations of very best occurrence and spread in Africa and Asia restorative medicines such as reverse transcriptase (RT) protease and integrase inhibitors represent expensive options. Currently only 50% of those medically eligible have access to effective treatment. A vaccine which would provide an ideal strategy is not yet available. In the light of these limitations novel preventatives such as a topical microbicide or an oral preexposure prophylactic (PrEP) are an urgent goal (13 37 51 HIV-1 access into sponsor cells has been proposed as an appealing drug target (50). HIV-1 infects macrophages and T cells by fusion of the viral membrane with the prospective cell membrane (4 19 The fusion process is mediated from the viral envelope glycoprotein which is derived from the proteolytic cleavage of a gp160 precursor into the gp120 surface protein and the gp41 transmembrane protein (26 33 34 38 The initial step of cell access is initiated from the connection of gp120 with the T-cell antigen receptor CD4 (2 15 44 CD4 induces conformational changes in gp120 that are postulated to promote subsequent methods in cell-virus fusion such as binding to the chemokine coreceptor CCR5 or CXCR4 and the exposure of heptad repeat 1 on gp41 (48 49 The second option transitions into a gp41 six-helix package ultimately NG52 resulting in membrane fusion (6 28 36 55 Interviral material including capsid protein p24 and reverse transcriptase are released into infected cells after fusion. Recently a new group of access inhibitors that allosterically block gp120 relationships has been developed. One such inhibitor is the small peptide 12p1 which antagonizes gp120 relationships with both CD4 and the coreceptor (5 17 23 24 A peptide triazole derivative of 12p1 HNG-156 includes a ferrocenyl triazole-substituted conjugate and binds to monomeric gp120 with an equilibrium dissociation continuous (worth of 12p1 (22 NG52 52 Both enzyme-linked immunosorbent assay (ELISA) and surface area plasmon resonance (SPR) analyses uncovered that HNG-156 maintained NG52 the capability to inhibit the relationship of gp120 with both Compact disc4 as well as the coreceptor and inhibited NG52 HIV-1BaL entrance using a nanomolar 50% effective focus (EC50) (22). Additionally a sequence-minimized type of the peptide was discovered to retain a lot of its antiviral strength at a significantly decreased size (52). Within this scholarly research we explored the antiviral breadth and mixture potential from the peptide triazoles. We examined HNG-156 and a smaller sized derivative against a -panel of subtype B and C isolates of HIV-1 and discovered that HNG-156 could inhibit a lot of the infections examined aswell as replication-competent scientific isolates. Small peptide was also in a position to inhibit a lot of the isolates examined albeit at higher concentrations. As the most reliable treatment for HIV-1 may be the usage of a cocktail of multiple medications targeting the pathogen we mixed HNG-156 with various other entrance inhibitors aswell much like the RT inhibitor tenofovir. We confirmed that HNG-156 could be matched with any applicant which it could be favorably coupled with many entrance inhibitors at the bigger concentrations apt NG52 to be utilized as treatment. Overall we discover that HNG-156 is certainly noncytotoxic and effective and gets the potential to become developed being a microbicide applicant to.


text: Headaches, nausea, achy joints… there are plenty of common health complaints that hardly phase you. They crop up, you call a doctor or use your favorite remedy and go about your day. Then there are the odd symptoms that pop up. They're at the very least confusing and they're often annoying. Yet ... Read More ›


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Contact Info
Fredric Dolezal (Ph.D. Theoretical Linguistics, University of Illinois Urbana-Champaign) is on the Advisory Board of the lexicographic journal Lexikos, published by AFRILEX (the African Association for Lexicography) and is Coordinator for the International Society for the History of Lexicology and Lexicography; he has research interests in literary lexicography and history of semantics and philosophical grammars, especially as these linguistically-based studies raise questions concerning the dictionary as text and the literariness of literary theory; the preceding is informed largely by his work on constructed languages and lexicons of the 17th century, classification systems, and other methods of transmitting and representing concepts across space and time.
Dr. Dolezal taught across the curriculum in Linguistics and English Literary Studies. His most recent courses included King Lear at the Movies; Film as Literature; Advanced Writing: Nature Writing, principles and practice; English Grammar; Seminar on Knowledge Representation and the Lexicon; Theory and Criticism: Linguistic Ideas in Literary Theory; Keywords in English: Language, Thought and Culture; and Lexicography.
Dr. Dolezal's most recent edited volume, Synonymy and Sameness of Meaning, is a special thematic issue of the International Journal of Lexicography (Oxford University Press). In the summer of 2016 he presented a paper at the 8th International Conference for Historical Lexicography and Lexicology, "Render into English that which is an historical reconstruction, or, The Lord's Prayer and Bishop John Wilkins's expedient 'daily bread'".
A new work crossing the domains of the history of the book and feminist historiography of linguistics, "Did Anne Maxwell print John Wilkins's Essay towards a Real Character and a Philosophical Language (1668)?", has been published in a collection entitled Historical Dictionaries in their Paratextual Contexts (Roderick McConchie; Jukka Tyrkkö, editors. De Gruyter, 2018); Ward J. Risvold, Lecturer at the University of California, San Diego, is co-author. A revised and expanded chapter, "World Englishes and Lexicography" will appear in the 2nd Edition of The Handbook of World Englishes (Wiley Blackwell, January 2020).