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"Fiesta Percusiva CD (Tortilla Flat 104114), Released 2008; Editor's Pick: A wonderful celebration of highly percussive, mostly Afro-Caribbean, rhythmic musical genres — with a bit of South America, too. This folklore-salsa-jazz project features a ton of percussionists. In addition to Victor Rendón there's Anibal "Tito" Rivera, Louis Bauzo, Tom Mattioli, Henry Brun, Guillermo "Memo" Acevedo, Ruben Rosa, Diego Lopez, Ramon Diaz and many others. Full review to follow shortly. Highly Recommended."
"On Line review by Roberto Rabbi at Salsa It." - Roberto Rabbi
— Salsa It
"Victor Rendon Fiesta Percusiva CD (Tortilla Flat 104114), Released 2008; Editor's Pick: Fiesta, yup, Rendon's not kidding. He's amassed a bunch of percussionist including Louis Bauzo, some marimba players, along with William Paul Rodriquez on piano and Carlos Velazquez on bass and the result is a pretty great descarga record for percussion. Rendon, who plays percussion, has varied up the instrumentation so that every track has a different sound; it's all hard and yet airy at the same time. There's some singing (some by Tito Rivera) and long grooves and it all adds up to an easy, intelligent look at how music making can be profound without anything but some essentials. And it's very, very relaxed, and special. Highly Recommended. (Peter Watrous, 2008-11-11)" - Peter Watrous
"Victor Rendón Fiesta Percusiva Legend tells of a fan who followed Charlie Parker from gig to gig in New York. Whenever his hero got ready to solo, the fan would activate a tape recorder he had set up near the stage. When the solo ended the tape was shut off, even as Dizzy Gillespie took his turn. Maybe there are equally devoted fans out there who would love to savor Latin percussion stripped as far down to the basics as possible, without any horn sections. If so, Fiesta Percusiva was made for you. When the tune is apparent, it's presented almost as a component o the rhythm instruments: Andrea Brachfeld's flute on "Afro Blue" sounds like an overtone of her line being doubled on marimba. Other tracks are equally or more bewitching without a single tonal note; on "Juego de Quijadas" caracoles, quijadas (a donkey jawbone), rain sticks, and other percussion evoke the sounds of nature itself, with help from some sampled cricket noises – all of this assuming that nature has a feeling for 6/8. With or without a melody, this stuff is magic." - Robert L. Doerschuk
— Traps Magazone
"Rendón uses Afro-Cuban percussion and marimba, quinto, tambourine, vibes, quijadas (donkey jaws), vibraslap, batá, drumset, and more to mix it up around some amazing old standards such as Afro Blue by Mongo Santamaria or the traditional batá or La Llorona. He also arranges and writes and does an excellent job of putting his wide folkloric and stylistic knowledge and many travel experiences to beautiful music. He has played so many styles such as rock, country and western, symphonic music, jazz and more. Bomba en Nueva York feels like you are in the barrio, on a hot summer night. The Funky Cumbia is as funky as it get." - Terry Reimer
— World Percussion & Rhythm Magazine
"The Art of Playing Timbales Book Reviews: I've been a drummer since the age of 10 and now being 24 have explored many different aspects of jazz, funk and especially Latin music. I began playing Latin percussion, exclusively, about 3yrs. ago and because of my up bringing in Puerto Rico thought I had a real handle on playing. WRONG!!! Latin percussion is all about timing, feel, and most importantly technique. This book not only breaks down the purpose of the percussion section but it helps the student understand the job of each instrument. True fundamentals describe this book the best. When you don't know what to do this book is a great guide for transitions, fills, patterns, and solo phrases to build a strong foundation to your musicianship. GO VICTOR!!! Thomas Dellamonica – Amazon.com After an eight year hiatus from playing both drums and timbales. My passion for keeping time has returned to full force and with this book I'm not missing a beat. Not only is this book well written but also very informative (you learned so much).It breaks everything(patterns)down to how to applied them in a drumset, conga, bongo or timbale setting(solo or ensemble). Bravo to Victor Rendon!!! Jose F. Serrano – Amazon.com"


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Robert L. "Bob" Nice
Mr. Robert "Bob" L. Nice, age 84, of Salem, passed away Saturday, November 3 at his home.
Mr. Nice was born December 12, 1933 in Washington County, Indiana the son of Banks and Anna Pearl Alspaugh Nice. He was former co-owner of Elaine's Restaurant and a Farmer. He served in the US Army at West Point, New York.
Robert loved spending time with his family, horseback riding, road trips, farming, IU Hoosier's basketball, geography, and history.
Mr. Nice is survived by his wife of 62 years: Elaine Davidson Nice. They were married June 10, 1956 in West Haverstraw, New York.
He is also survived by five children: Barb Davis (Steve), Jeri Lynne Snelling (Bobby), Rita Lyles (Bryant), Neal Nice (Michelle), and Heather McNeely (Billy) all of Salem, two brothers: Junior Nice and James Nice both of Salem, a sister: Nona Cole of Salem, ten grandchildren: Robbie Lyles (Jenny Lockard), Corey Baker (Adrienne Combs), Justin Davis (Amanda), Ashleigh Alexander (Bronson), Brandon Davis (Lindsey), Jared Davis (Janice), Brianna Misamore, Lane Nice, Madison Misamore, and Cody Nice, 5 step-grandchildren: Bailee McNeely, Jackson McNeely, Bryson McNeely, Jenah McNeely, and Zackary Lockard, and 10 great-grandchildren: Jordan Baker, Natalie Baker, Mazie Lyles, Raiden Lyles, Braxton Davis, Alyssa Davis, Amelia Davis, Isabelle Davis, Brenleigh Alexander and Rogan Davis.
He was preceded in death by his parents and siblings: Dale Nice, Stanley Nice, Raymond Nice, Ruby Humphrey, Betty Strange, Anna Mae Zink, Hazel Voyles, Patricia Floyd, Helen Branaman and Richard Nice.
Funeral services will be held Wednesday at 11:00AM at Weathers Funeral Home with Pastor Tom Fultz officiating. Burial will follow in Kansas Cemetery with military honors. Visitation will be Tuesday from 4-8PM and Wednesday from 9AM-time of services.
Memorial contributions may be made to Kansas Church Cemetery Fund.
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SQL Server – Show/Hide Results Pane in Management Studio 2012
In earlier version of SQL Server Management Studio (2005, 2008 and 2008 R2) you can show/hide results pane using keyboard shortcut Ctrl+R. This shortcut was also present in Query Analyzer (SQL Server 2000).
This shortcut is no longer available in SQL Server Management Studio 2012. In this version you need to use Ctrl+Shift+Alt+R to show/hide query results pane. Another alternative shortcuts you can use to show or hide results pane is Alt+WS and Alt+WI respectively. I find the later to be more easy to use.
If you have gotten used to using old shortcut Ctrl+R you can customize shortcuts in SQL Server Management Studio.
To change keyboard shortcut for show/hide results pane:
Step 1: Go to Tools > Options in SQL Server Management Studio:
Step 2: Navigate to Environment > Keyboard > Keyboard
Step 3: Search for Window.ShowResultsPane using Show commands containing: textbox.
Step 4:
(1) Select Ctrl+Shift+Alt+R (SQL Query Editor) in Shortcuts for selected command: list.
(2) Select SQL Query Editor in Use new shortcut in: list.
(3) Go to Press shortcut keys: textbox and press Ctrl+R or any other shortcut you need.
(4) Click on Assign.
(5) Click on OK to apply changes.
Step 5: You need to restart SQL Server Management Studio to apply these changes.
Note: The Window menu will still show Ctrl+Shift+Alt+R as shortcut we have only added an additional shortcut, we have not removed existing shortcut.
Hope This Helps!
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Question #8 My buddy is cohabiting or living together with his girlfriend and isn't married. Can he be a Catholic godfather?
This is Question and Answer #8 in a series on Godparents. Each day I will answer a question. If you have your own question, please post it as a comment to this post. Thank you.


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Greetings friends, we would like to welcome you to our website and below you will find all the listed Crossword Quiz Daily January 1 2019 Answers answers and solutions. The idea behind this puzzle solving game is simple and is quite entertaining. We urge you to get all the answers and solutions of Crossword Quiz and we also have answers of Lost For Words Answers.
Have you ever wonder why you love to play Crossword Quiz game because it is certainly worth it. We have made sure you get every single solution and answer whenever you need on daily basis. But still if you require more answers then check out Crossword Quiz Daily December 31 2018 Answers, Crossword Quiz Daily December 30 2018 Answers, Word Whizzle Search Daily Puzzle November 28 2017 Answers and Jumble Crosswords February 13 2018 Answers and try using them to know more about games then keep visiting our website.
We would like you to bookmark this page immediately. If you like to know more then you can check on Crossword Quiz for future references. Thank you very much and keep visiting our website.


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Great for any PJ Masks fan, this colourful Owlette design lunch bag is a great addition for lunch time!
The PJ Masks lunch bag is insulated to help keep lunch cool and fresh for longer. Features a carry handle and zip closure. Wipeable food safe PVC free lining for easy cleaning. Ideal for lunches, picnics and days out.
Includes a PJ Masks drinks bottle with an easy open twist lid which helps keep the straw clean when not in use. Features a leakproof lid. Straw detaches and lid comes off for easy cleaning.
Lunch bag is approx 21.5cm (w) x 25.5cm (h) x 8cm(d).
Suitable for 3 + years


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There are 6.5 miles of trails for walking, biking, running, or skating. The pavement is really smooth, so skating is a breeze.
You may even run into some mooing creatures who hang out next door.
My favorite trail area is The Ramble because it's a hilly, wooded area. Very fun to go fast through here on my skates when nobody is around!
In the park's 130 acres, there are many ponds and geese, gulls, and ducks that hang out in them. In the large pond there is also a gigantic school of, what I believe are, orange koi fish.
I brought a little friend with me to the park and we found a turtle around one of the ponds!
It's a great place to walk dogs, too. Look at that smile on my Lola.
We met Paris, the male white poodle, there one day and he was all jazzed up for St. Patty's Day. I wasn't sure if I should be laughing or making a call to PETA.
There is a large kids' play area with a spongy surface. No bumps or bruises here! Plus there's a small maze garden.
Click here for the trail map and distances.


text: Freedom from Hate 101 East returns to Myanmar to investigate the religious hatred plaguing the country. 101 East 06 Sep 2013 08:37 GMT Australia, India, Myanmar Religious and racial hatred simmers in the once repressed southeast Asian country of Myanmar. Optimism for the country's reforms is fast fading as tensions between majority Buddhist and minority Muslim communities have left over 250 people dead and displaced more than 140,000. In the newly liberated media, free speech has quickly turned to hate speech, drowning out moderate voices. Some say powerful interests are igniting decades of suppressed prejudice in order to derail the country's transition to democracy. Unless leaders and moderate voices are willing to speak out, only the loudest and most extreme voices will be heard. Unless the country can come to embrace its diversity, and see it as a strength, peace and stability could remain elusive. Pro-democracy campaigner Aung San Suu Kyi famously wrote about freedom from fear, but can Myanmar now free itself from hate? 101 East returns to Myanmar to investigate whether dark schemes are at play, or if the country faces a more fundamental problem - a crisis of national identity. Is freedom from hate possible in Myanmar as religious violence flares? Share your thoughts with us @AJ101East #MyanmarViolence Filmmaker's view By Aela Callan He spoke with eyes narrowed, as if trying to look inside us as he peered over the top of his newspaper. He was asking whether my companion and I were Muslims. Tired after hiking for two days through stunning mountains in Myanmar's Shan State, we had finally arrived at this Buddhist monastery moments ahead of the monsoon rains. We were hoping to shelter here for the night. "Ah, ah, I told him you are Christians..." stammered our guide. "But I don't practice any religion," I insisted, peeved that I was even being asked. For more from Aela Callan in Myanmar, download the latest issue of the Al Jazeera English digital magazine In Myanmar, "Where are you from?" is asked before your name. Your religion is then assumed, based on your answer. It is part of a system of deduction common across many cultures. If I say I am Australian, it must mean I am Christian. Freedom from Hate tackles one of the most difficult topics I have explored during 10 months living in Myanmar and over four years reporting from here. My Western sensibilities have struggled to comprehend the breathtaking racism and blatant religious discrimination I witness on a daily basis. The easiest example to point to is the use of the word 'Kalar', originally the Myanmar word for foreigner, now almost exclusively used to define dark-skinned Muslims. Often uttered with contempt, it is also used by community leaders and is rampant on Facebook since censorship has been lifted. I have been bewildered to hear friends who fought for democracy in Myanmar, quip over dinner conversation that Muslims are breeding incessantly and expanding their business empires with Islamic financing, as part of a plot to take over the country. It is shocking stuff to people who were brought up to be politically correct or to subvert racism. But instead of dismissing these narratives, I wanted to understand why people emerging from decades of repression would turn on their own countrymen. The best explanation I could come up with is a national identity crisis. What it means to be Myanmar has never been clearly defined and this is apparent in many ways. Successive post-colonial governments, including the military, have pushed the idea that to be Myanmar you must be Buddhist. This excludes hundreds of diverse ethnic and religious groups who make up significant parts of the country. Yet no one knows how significant, because there has been no clear population data available in decades. In the absence of clear figures defining the ethnic make-up of the country, irrational fears can not be dismissed with clear, logical facts. Some estimate the Muslim population to be five percent, some say 25 percent. In an open society that is aiming for democracy, demographics also matter to the political landscape. And that is another sore point, particularly in Rakhine State in the country's west, where ethnic Rakhines believe the Rohingya minority are systematically trying to outbreed them. On Myanmar's national identity cards, Muslims are often identified as foreigners; Bengali, Pakistani or Indian, regardless of how long they or their ancestors have lived in Myanmar. Designations are often random, with race and religion listed together, creating the idea that they are one and the same. It is a highly confusing system that leads to people who have never been to India being listed as Indian, and members of the same family being deemed as being from different south Asian countries, because they are Muslim. The notion that Muslims are the 'other' is easily absorbed, regardless of ethnicity, when promoted by the monkhood, which is revered as the country's moral authority. In particular, the now infamous 969 group unashamedly distributes nationalistic propaganda. But if Myanmar's problems could be solved by silencing a few monks, it would be easy. It took the stroke of a sub-editor's pen to declare the group's revered leader, Wirathu "The Face of Buddhist Terror" in Time magazine's July issue. Unsurprisingly, this was seen by many as a direct attack, not just on Buddhism, but on Myanmar as a whole. It is possible to argue the semantics of hate speech with Wirathu all day long. Whether or not he is guilty of it depends on if you regard his vilification of Muslims as an incitement to violence. But the key issue is that his ideology resonates. And it resonates so much because it is a narrative that most people in Myanmar are comfortable with. Indians, many of them Muslim, were imported by the British during colonial times and placed on a higher social tier, easily breeding resentment. Never mind that other Muslim groups existed in the country before the Anglo-Burmese wars. Sadly, since the Time issue, a siege mentality has developed among Buddhists across Myanmar, who believe that reporting on this issue is part of a Muslim plot. Members of the local and international media are threatened, attacked on personal Facebook pages, have their websites hacked and their faces plastered across banners carried in protests. It is both sad and distressing to see free media attacked by people who for so long fought for a voice. I was constantly videotaped while shooting Freedom from Hate, by both Buddhists and Muslims, out of fear of being misquoted or misunderstood. It is an understandable reaction, yet I cannot escape the irony that for years I was followed and documented by the authorities, only to be followed and documented by the general public in the newly free Myanmar. During my time with the 969 group, one monk asked where I was from, then pointed out that Australia's former prime minister had told Muslims they should accept the country's laws or go home. Notwithstanding a few critical details he had confused, I accepted his point that other countries also express attitudes they can not be proud of when it comes to immigration. I told him that Australia's strength lies in its diversity. The optimist in me would like to think that attitudes have come a long way since my parents' and grandparents' generation, and they are able to change in Myanmar as well. Racism is ugly anywhere, but it seems particularly painful in Myanmar because it is a country that holds promise for the first time in decades. The foreign media is naturally responding to what it sees happening in the newly free country. After shocking religious riots, messages of hate from the mouths of monks or plastered over Facebook make great headlines. But, ultimately, Myanmar is a country where education levels average grade five, where reverence towards monks goes unquestioned, and where decades of misinformation have fed a culture that thrives on conspiracy theories like no other. Myanmar's people now face difficult questions. As the country hurries toward modernisation, can it turn perceived differences into strengths for the betterment of its future? Or will it allow hatred and fear to burden its ascent? I look forward to a day when the people of Myanmar will be able to look inward when they ask, "Where are you from?" and consider how diversity will help, not hinder an emerging democracy. 101 East airs each week at the following times GMT: Thursday: 2230; Friday: 0930; Saturday: 0330; Sunday: 1630. Watch more 101 East Source: Al Jazeera Tell us what you think


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by Mick Hammond – MMAWeekly.com
With the lightweight division experiencing a rebirth in the US this year there's going to be a lot of fighters vying for the top spot. Among the favorites to become the number one lightweight fighter in the US is current King of the Cage 155lb Champion Mac Danzig.
Recently this past March after nearly five months off from fighting, Danzig returned in victorious fashion over a very tough Jason Ireland at KOTC: Drop Zone. It's a fight that while Mac is happy he won; he feels he could have done a better job of preparing for.
"It didn't go exactly as I expected," admitted Danzig. "I feel like may have under prepared for him. Not that I didn't train hard, I trained really hard and I was in good shape, I think that I didn't get enough tape on him and didn't really have a game plan. That's probably what the problem was, I just went in there and winged it and at this level it's dangerous to do that."
Mac continued, "He came in and fought really hard and it was a really tough fight. It was really good from a fan standpoint but I wasn't really happy with it until I saw the tape recently and realized it wasn't that bad. I'm just disappointed because I didn't finish it. It was actually a very good, competitive fight."
With his first title defense in the books Danzig now sets his sights on his second trip up to KOTC Canada to defend his title against Orlando Ruiz this weekend in Calgary, Alberta. According Mac while the fight might not appear dangerous on paper, it's not something he's going to take lightly.
"This is the most dangerous kind of opponent," exclaimed Danzig. "For one he's got a title shot so he's going to be fighting very hard and for two I don't know anything about him. The guy supposedly is 9-0 in MMA in Puerto Rico, which may not have great competition, but he may have some skills."
Mac added, "On paper I should be able to walk through this guy, but you ever want to underestimate anyone and you don't want to lose to this type of guy. I don't know what to exactly expect from the guy but I expect his best effort. If I go in there and underestimate him that's very dangerous, so I'm going to go in there and treat him like any opponent."
This fight will be the third in a row that Danzig has headlined a card and is expected to bring in the crowd. While it may be difficult for some fighters to deal with that kind of pressure, to Mac it's nothing he hasn't adjusted to and can't handle.
"I don't really get too nervous or have too much pressure. I definitely want to go in there and put on a good show and prove why I'm the Champion. I'm pretty comfortable with where I am now in the sport, so I'm just going to go do what I do," said Danzig.
After Ruiz, Mac already has two more fights signed for the coming months, neither of which he expects to be easy.
"I've got a couple tough fights lined up. On June 9th at Soboba I've got Buddy Clinton who's dropping down in weight to fight me and that's a pretty tough fight at 155lbs for a title defense," explained Danzig. "After Clinton I've got this German guy named Mario Stepel. He's not really known over here, but he's supposed to be one of the best fighters in Germany at 155lbs. I'm supposed to be fighting him in August considering I beat my next two opponents. After that I'm not sure, but I've been told hopefully I'll get a bigger named guy, a top ten or top fifteen guy."
Mac closed out the conversation by saying, "I'll keep taking it one fight at a time and I'm not looking past anyone. I'm just looking at my opponent this weekend, after that take a week off then get ready for Buddy Clinton, knock him out, and get back on the train [laughs]."
Danzig concluded, "I want to thank my sponsor Warrior Wear and like I always say, no matter what I'm going in there and giving it my best. It's just going to be like every time, exciting, and I'm hoping to finish this guy, no more decisions for me."


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Mars Closest to Hudson Valley in 15 Years
On Tuesday, Mars is the closest to Earth it's been in the past 15 years and it won't be this close again for another 269 years.
On July 31, the Red Planet will be closer to Earth than it's been in the past 15 years. According to NASA, we'll be just 35.8 million miles from Mars as compared to the average distance of 140 million miles.
"35.8 million miles is definitely not what most of us would consider 'close,' NASS wrote on its blog. "But in planetary terms, close is definitely relative! Because Earth and Mars have elliptical orbits and are slightly tilted to each other, all close approaches are not equal."
Earth and Mars won't be this close again until 2287. However, in October 2020, the two planets will be 38.6 miles apart.
Mars should be visible to the southwest throughout the early morning. If you missed it, or the sky was too cloudy when you looked, NASA posted two live feeds. One can be seen by CLICKING HERE --- the other HERE


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Pats, Seahawks prove again that they—and their coaches—are very best NFL has to offer
FOXBOROUGH, Mass. — Behold the power of good coaching.
For the third head-to-head meeting between Pete Carroll's Seahawks and the Patriots of Bill Belichick, both teams again delivered a masterpiece in a 31–24 Seahawks victory, a thriller at Gillette Stadium that once again went down to the final play.
And in a microcosm of the short-lived but epic rivalry, it came down to a mono-a-mono steel cage, death match: a 1-yard fade from Tom Brady to the two Adonises on each team, Patriots tight end Rob Gronkowski and Seahawks safety Kam Chancellor. They locked arms, engaged in an equal shoving match, neither could make a play on the ball, and the ball fell harmlessly incomplete with no flag on the play (on that, you could almost hear the sigh of relief coming from 200 miles away in the Art McNally GameDay Central officiating command as another NFL controversy was averted on national television).
With seven lead changes, the game was great theater. And on the back of an equally compelling cross-conference clash between the Cowboys and Steelers (another seven lead changes in a 35–30 Dallas road victory; give it up for the NFC), we were reminded, with perfect timing on the Sunday after a polarizing Presidential election, of how prodigious and entertaining the NFL can be.
NFL Week 10 Blanket: Cowboys-Steelers thriller may be turning point of this season
The kind of matchup like the one we saw Sunday, ones that feature well-coached teams, great quarterbacks, simple schemes that are (usually but not always) executed well, unmatched mental toughness and hard hitting, are few and far between. Unfortunately, what most coaching chess matches look like in today's NFL are normally played on the checkers boards outside of a Cracker Barrel.
But that's not the case with Carroll and Belichick.
Of their matchups against each other so far, the Seahawks have taken one on the road and one at home, with the Patriots taking the neutral-site tiebreaker 28–24 in Super Bowl XLIX, which also ended on a controversial playcall near the goal line on the final play. (Halo, the rub-route slant the Seahawks tried that was picked off by Patriots cornerback Malcolm Butler, it's time to meet The Fade.)
Those three matchups between the Seahawks and Patriots have an aggregate score of Seahawks 79, Patriots 75 (the all-time series is also tied 9–9, by the way).
There was the, "You Mad Bro?" game at Seattle in 2012 that introduced a nation to the Legion of Boom and launched the Seahawks' reign of domination in the NFC with a 24–23 victory after Seattle trailed 23–10 in the fourth quarter.
Of course, there was the, "Malcolm, Go!" Super Bowl showdown, which delivered the Patriots their fourth Super Bowl title under Belichick (first in 10 years) and thwarted Seattle's bid to be the first team since—who else—the 2003-04 Patriots to go back-to-back.
Cowboys' unrelenting offense stars in dramatic win over Steelers
And then there was Sunday night, which saw Russell Wilson (348 yards, three touchdowns to Doug Baldwin) and Brady (316 yards) matching each other, dime throw for dime throw, throughout the night.
The good news is that it was as much fun to play in that game as it was for us to watch.
"Oh yes," said Seahawks linebacker K.J. Wright. "That's what guys dream of. We dream of Sunday night football. We dream of goal-line stands. We dream about getting turnovers. It's so fun for us. We were out there talking about, 'Finish, finish, finish. Bow up. Bow up. Don't let them in. Don't let them in.' That's something that you remember 10, 20 years down the line."
I don't think anyone would complain (outside of Dallas and Pittsburgh, who will each have a big say in it) about a fourth installment of Carroll v. Belichick on Feb. 5, 2017 in Houston for Super Bowl LI.
When it comes to today's NFL, Carroll-Belichick is like a lush oasis after slogging miles through the dry desert that is the rest of the NFL slate on any given Sunday (just try watching one game in the AFC South). Unlike previous decades of the NFL, when coaches like Shula, Landry, Noll, Parcells, Walsh, Gibbs and Grant often matched wits, Belichick and Carroll are unmatched among their peers.
You got a sense after the game on Sunday night that the two combatants realize that as well. The two had a long embrace, some meaningful words and walked arm in arm for several steps. For tight-lipped Belichick, that's a few steps shy of walking down the aisle.
"This is a really good win today because of who we just played and the kind of club this is—coaching staff, players, history, the season that they are having," said Carroll, who likely took a lot of personal pride in delivering a victory in a place where he was summarily fired by the Patriots. "We have great respect for them and so it's a really good accomplishment by our guys. … They do so many good things and so many great throws and catches by their best players and they made it hard on us, but when it got down to it, when you get a chance to on the 1-yard line, nothing like it in football. It's one of the great challenges that a team and a defense gets and we've had some bouts down there the last few weeks and our guys just came through and hung in there and fought for every inch. And let us walk away with a win on this one, so it was a really cool night of football and it's really because we respect them so much, is really why I say that."
Belichick gave off the same positive vibes as well.
Despite trailing Panthers until final second, Chiefs scrape out fifth straight win
"They're very well-coached," he said. "They're tough. They compete on every play. They have a lot of good players. They have a lot of good players who play good, as we do. It can't get much more competitive than it was out there tonight but give them credit. They made more plays than we did. They did a little more than we did tonight. That's why they won. … They're good on offense, they're good on defense, they're good in the kicking game. Every play is competitive. There are no plays off. You've got to do a good job on every single play. That's what it takes to compete against them. You can start with [Russell] Wilson. I mean you can go right down the line. I mean whoever you want—Wilson, [Richard] Sherman, the backs, the receivers, the tight end, the front, the edge rushers, secondary, the linebackers, the kick returner. Take whoever you want. They're tough. It's not easy to make plays against them. We made a lot of them. They made a couple more so give them credit. They deserve it tonight."
Belichick vs. Carroll. Patriots vs. Seahawks. It's the very best the NFL has to offer, and last night was just another example. Hopefully both teams continue to play at a high level so that we might get a fourth installment. These games are a national treasure, and we don't want to imagine an NFL without them.


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AutoDevBot Open Sources Their API Monitor
The API monitoring service AutoDevot has opened sourced their JavaScript API monitoring solution, built on Frisby.js, called API Monitor Runner. The API monitoring tool, allows for a pretty robust configuration file, that lets you detail exactly what the service should monitor, and how it should behave when something out of the ordinary happens.
I though the trigger actions stood out, allowing you to take common actions when something occurs with an API:
- TRIGGER_EMAIL - enable email notification
- TRIGGER_PAGER_DUTY - enable PagerDuty notification
- TRIGGER_WEBHOOK - enable a generic webhook notification
- TRIGGER_HIPCHAT- enable HipChat notification
AutoDevBot, even takes things to another level, providing a ready to go Docker container, to quickly deploy API Monitor Runner, and then configure it on setup, using Docker environment params--a very interesting approach to deploying open tooling to support APIs.
I really like this type of deployment for vital API services, focusing on providing a simple, valuable, cloud-based service, as well as an open source version that anyone can put to use. We just saw the same moves from 3Scale with the release of APITools, and now AutoDevBot with API Monitor Runner.
I'd love to see other critical building blocks of the API economy emulate this approach—there is plenty of money to be made from cloud services, while also providing open tool that will stimulate API growth across many business sectors. Which, creates more need for services.


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13 killed in under-construction building collapse in Pune
Thirteen construction workers were killed when a slab of an under-construction building collapsed at a village near Pune on Tuesday.
Thirteen labourers were killed and several others trapped when a slab of an upcoming college building collapsed in a village here Tuesday, police said.
The incident took place in Wagholi, around 20 km from Pune city, where a new building of an ayurvedic medical college was being constructed.
"Many labourers were working on the fourth floor of the building when a slab gave way. We had initially pulled out bodies of four labourers. The toll has gone up to 13 now," a police official said.
"Rescue operations are still underway and we are checking if there are more people trapped under the debris. However, most of them have been pulled out. One other labourer under treatment is in critical condition," he added.
However, the identities of those killed have not been ascertained yet.
Fire brigade personnel were successful in rescuing one of the workers trapped under the debris.
Police said they were investigating the quality of construction materials, after which a case would be filed against the persons responsible.
Most of the victims were reportedly contract labourers from outside Maharashtra, police said.
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Oct. 5 — 102 calls for service
Officers responded to the 1300 block of Greenwood Avenue on a report of a structure fire.
Officers responded to the 2700 block of Fremont Drive on a report of a hit-and-run motor vehicle accident. A Green pickup truck failed to maintain its lane as it turned westbound onto U.S. 50 from Raynolds avenue, sideswiping a white 1998 Honda by Niechelle Feeney of Durango. No injuries were reported.
Officers responded to the 1100 block of Harrison Avenue on a report of an animal complaint.
Officers responded to the Police Department Lobby on a report of a wallet lost in the 1800 block of Fremont Drive.
Officers responded to the 300 block of N 19th Street on a report of a trespass.
At 4:44 a.m. Oct. 5, Cañon City Police were dispatched to 300 block of N 19th street for a trespassing subject.The homeowner confronted two subjects on his property near his garage. A physical altercation ensued and the homeowner was stabbed. The subjects were last seen running west on Franklin Avenue. The injury to the homeowner is reported as non-life threatening. Items on the property were damaged during the incident. This case is open and under active investigation.
Officers responded to the 3100 block of U.S. 50 on to assist a motorist who had hit a deer.
Oct. 6 — 79 calls for service
Officers responded to the 700 block of Harrison Avenue on a report of a civil incident.
Officers responded to the 100 block of W Caitlin on a report of trespass.
Officers responded to a telephone call regarding a theft in the 600 block of Raintree Boulevard.
Officers responded to the 1800 block of Barr Avenue on a report of a burglary. A detached garage was entered and several tools were stolen including a 7 inch angle grinder, a Milwaukee sander, a Dewalt Cordless drill, charger and batteries, a Dewalt electric sander and a ¾ inch impact driver.
Officers responded to the 1000 block of U.S. 50 on a report of criminal mischief.
Officers responded to the 400 Block N Cottonwood on a report of misdemeanor Menacing that occurred along the Riverfront trail near the train station.
Officers responded to the 700 block of Main Street on a report of an open door.


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I have 6 grandchildren. My daughter has 4. 2 boys, 2 girls, Now she has 3 of them in college this year. My son has 2. The two blonds on the right in this picture. They live in Colorado so we don't get to see them very often. This picture was taken this summer when they visited for a few days with us and then Their other grandmother had them for about 3 weeks. The other girl on the left is Ashley, my daughters oldest girl. She's in her second year at art school in Philadelphia.
Notice Chris has this blond hair. getting a little darker than it used to be. He's 13.
Well, last night I got an email from my son with a couple pictures. This one below
Chris said in the email, Purple Hair eeeeee!!!!!
I wrote back and said whats the story. Nothing he went to a salon to get it done. With his own money.
Now Why would a nice looking boy with nice - but long, hair want purple hair? Just like the hippies in the 50's.
Guess this is the style in the Mountains of Colorado. What do you Think?


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American Heart Month: How to Increase Your Heart Health
February is American Heart Month, do you know the steps to take in order to make your heart healthier during this day of awareness?
Along with Black History Month, February shares our hearts in another way: by raising heart health awareness. Your heart is a muscle, and like every other muscle, it needs to be treated right and exercised in order to remain healthy. Visiting your doctor, eating the right foods, and exercising are all habits you can create in order to increase the health of your heart. Let's go a little bit more in depth as to how each of these can help your heart and how you can celebrate American Heart Month.
Visit Your Doctor
Your doctor can detect any signs of heart disease and recommend dietary, physical, and medical advice in order to get your heart healthy. When it comes to issues of the heart, early detection is crucial as it can prevent a more serious heart issue down the line.
Eat Plenty of Vegetables
Vegetables can do wonders for your heart. They contain all the nutrients it needs without all of the nasty grease, fat, and oil that comes from eating meat. While meat can be healthy, you should decrease your meat consumption to once a week. It's not only good for your heart, it is great for the environment, too!
Get Exercise Regularly
Exercise strengthens your heart. Exercising for only 30 minutes at least three times a week can really make the difference. You can start by walking 15 minutes and then increase it to 30 minutes once you feel comfortable to bump up your workout regiment.
You can also contact the Thousand Oaks Police Charitable Foundation in Thousand Oaks, California to get a few tips on how you can use your heart to give back to the community! Register here!


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Rich Insights into two of the UN's outstanding leaders
Boutros Boutros-Ghali and Maurice Strong
Two books[1], just published show how the UN has gained global influence through the leadership of exceptional individuals. They are fascinating both for the insights they offer and for the sharp contrasts in the personalities and approaches of the individuals they recall. Remembering Boutros Boutros-Ghali recalls the highly-intellectual UN Secretary-General from 1992-96 and Remembering Maurice Strong, the self-made Canadian businessman and inspirer and organizer of the two great environmental conferences, in Stockholm in 1972 and the Earth Summit in Rio in 1992.
BBG, as he was commonly known and Maurice, as he was widely known to friends, were totally different in upbringing, background, careers, styles, approaches and roles in the UN. Yet in contrasting ways, both were major influences on the UN and on international policy and action, BBG primarily in the 1990s and Maurice over four decades from the 1970s.
The two books about them are reminiscences not biographies – all the stronger and more fascinating because each brings some 40 different viewpoints, from those who had worked with BBG or Maurice, in the UN or who had advised or mobilized closely on its edges. The diversity of contributors provides varied and often contrasting perspectives on each of them in a way missing from most biographies –reflecting, for example, BBG's strong commitment to the G-77 brought out by Ahmia Mourad, his highly intellectual approach by Nitin Desai and his strong sense of self and ambition, brought out by Patrizio Civili. Such perspectives from close insiders is a useful antidote to the views of outside critics and governments of the North, especially perhaps of the US which used its veto to prevent BBG receiving a second term, making him the only SG to serve only 5 years.
Alexey Vasiliev's piece brings out how BBG, a convinced liberal, had pre-UN experiences which convinced him of the need for a multi-lateral and balanced approach between the West and the Soviet Union. Vasiliev's piece, Patriot of Egypt and friend of Russia, traces BBG's distinguished and extraordinary multi-national background – fluent in Arabic, English and French, Professor at the University of Cairo, scientist, diplomat and former student of the famous Science-Po in Paris, possessing French, Egyptian and American diplomas, an Arab and an African, an Arab Coptic Christian married to a Jewish wife coming from a rich family. He had been active with Sadat in establishing peace between Egypt and Israel and an architect of the Camp David peace accord.
The tragedy of the 1990s and of BBG is that in spite of this background and his own efforts – and wider UN efforts, including by the Economic Commission of Europe – the West opted for a sudden big-bang approach to the introduction of capitalism in the post-Soviet Union instead of a gradual approach, steadily building up the institutions for a market and democratic society.
BBG brought to the UN deep personal convictions and his own intellectual capacities that the SG should be a global leader in ideas. With this, he had considerable success. He produced two important documents –the Agenda for Peace and the Agenda for Development, both still worth reading. He also encouraged, as Ismail Serageldin brings out, the six agenda-setting summit meetings of the 1990s – on Environment and Development, Population and Development, Social Development, Women Empowerment, Food and Hunger and Urbanization and Cities.
When he left the UN in 1996, (after the veto for a second term) BBG continued his activism, intellectual contributions and sometimes frustrations encouraging Muchkund Dubey to write "Multilateralism Besieged" for Kofi Annan's Commission on Threats, Challenges and Changes. The reminiscences contain several relating to BBG's later leadership as President of La Francophonie, the international organization of French-speaking countries and his strongly supportive role of the South Centre, a leading research group on international issues, founded to provide a third-world perspective in contrast to that of the OECD. It should be noted that BBG for 15 years strongly supported, in his capacity as ECPD Honorary President, the activity of the European Center for Peace and Development headquartered in Belgrade.
Maurice Strong's influence within the UN was much longer and in total contrast, over more than three decades from the 1970s and being an extraordinary force of influence, although only for short periods holding any formal executive position. Nitin Desai (a former UN Under-Secretary-General for Economic and Social Affairs) who worked closely with him identifies Maurice's his major contributions:
- As Secretary-General of the two path-breaking environmental conferences, Stockholm and the Earth Summit in Rio.
- As the first head of UNEP
- As leader of the UN relief efforts during the great drought of Africa in the 1980s
- As the architect of UN reforms under Kofi Annan
- As the Rector of the UN University of Peace in Costa Rica
- As a Special Representative of the Secretary General charged with finding a peaceful solution to North Korea's nuclear ambitions.
What makes Maurice so fascinating as a global mover and shaker is the source of his influence and his ability to inspire, keep and use an extraordinary range of contacts, at the highest and more modest levels. Political scientists and international relations experts who search for power behind all international action need to ponder the lessons of Maurice Strong. He left school early, became a junior beaver trader in Manitoba and soon developed as a self-made rich businessman. By 1964, aged 39, he was Executive-Vice President of the Power Corporation of Canada, an investment holding company. But his aims went far beyond money-making. From his early years Maurice had unusual and exceptional global vision and commitments – for the environment, for international action and the UN and for bettering humanity.
He also developed exceptional talents for identifying and building relationships with people with power and influence. James Wolfensohn, (much later President of the World Bank) describes his early contacts with Maurice to the 1960s when they were both involved in investing in a 2 million acre property in North West Australia. His entrepreneurial and leadership talents stood out and by 1966, as Jack Austin(a former Canadian Minister and Senator describes) Maurice had left the Power Corporation to become founding head of CIDA, the Canadian International Development Agency and then head of IDRC, the pioneering International Development Research Centre.
This combination of strong links with the Canadian government and the private sector provided Maurice with a supportive base for his many international contributions. He also built and maintained links with visionary intellectuals and academics. He commissioned Barbara Ward with Rene Dubos to write "Only One Earth: the care and Maintenance of a Small Planet", drawing on a group of 70 experts from around the world. Maurice played an important role in the Society for International Development and was Chair of the NorthSouth Roundtable –where he interacted closely with Mahbub ul Haq, Jim Grant, myself and many others.
Maurice was skilful in listening, developing and adapting messages and policies to win consensus. In the early stages of mobilizing support for Stockholm, he learned of the third world suspicions at the time about the environmental cause: "The global sink of pollution has been filling up and third world development must now be slowed or sacrificed to prevent it overflowing". In response, Maurice organized the Cocoyoc Seminar with leading development economists and which he later described as "a major turning point in the development- environment dialogue" as Paolo Bifani recounts.
Hanne, his wife, played a long and supportive role to Maurice's endeavours, perhaps especially for the spiritual element in his beliefs and in their respect for all faiths of the world. Rajendra K Pachauri, (Chairman of the International Panel on Climate Change) talks of first understanding Maurice's multi-faceted personality through meeting with her. He then joined Maurice in Beijing in 1991 with a small group of foreigners and a select group of Chinese, in discussions which led to the setting up of the China Council for International Cooperation on Environment and Development.
Martin Lees (onetime Rector of the University of Peace of the UN and SG of the Club of Rome) identifies the attributes of Maurice which made him so effective: his determination to contribute to a better world and his commitment to international action and the UN; his positive attitude and vision; his engagement and vision being moderated by practical experience and realism. Lees also adds that "If Maurice had not been Canadian, I find it hard to believe that he could have played such a successful role in building international consensus for concerted action to face the challenges of the modern world." Or as Sonny Ramphal puts it, "Maurice Strong, ineluctably, had two countries: Canada and planet Earth".
The tributes and reminiscences about BBG and Maurice Strong in this collection are too many and too wide-ranging for a reviewer to give more than a few glimpses of the details they offer about international action and the ideas and leadership which BBG and Strong provided.
Frederico Mayor, Negoslav Ostojic and Roberto Savio deserve thanks and many congratulations for assembling such a rich and diverse collection of substantial reminiscences, both insightful and inspiring. One is left as Tom Lovejoy (a senior Fellow of the UN Foundation) writes, it is hard to imagine a world without the whirlwind of perpetual activity that was Maurice. Both books are a reminder of what inspired leadership can achieve and an inspiration to all of us to carry forward such a global vision.
Richard Jolly
[1] Federico Mayor, Negoslav Ostojic, Roberto Savio (eds) Remembering Boutros Boutros-Ghali: a Visionary Internationalist and Global Leader-Tributes and Reminiscences (European Center for Peace and Development, Beograd) 2018
[1] Federico Mayor, Negoslav Ostojic, Roberto Savio (eds), Remembering Maurice F Strong ; Tributes and Reminiscences (European Center for Peace and Development, Beograd) 2018


text: The Institue of Management Accountants has published a fairly exhaustive description of what management accounting is all about. If you hold that kind of position and this document identifies any activity you're not performing today, then it should give you ideas to keep you busy for a while. And add value to your organization, too.


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SANTA MONICA, Calif., Jan. 9, 2012 /PRNewswire/ — The makers of WEN® by Chaz Dean, the revolutionary one-step cleansing conditioner, are proud to support the Miss America Organization as a sponsor for the 2012 Miss America Pageant hosted at Planet Hollywood in Las Vegas January 14, 2012 on ABC.
The 2012 Miss America Pageant events officially kick-off the partnership between WEN and the Miss America Organization. In the weeks leading up to the pageant, celebrity stylist Chaz Dean, creator of WEN Hair Care, will interact and style a variety of contestants' hair, allowing each contestant to experience the WEN hair care difference.
"We are proud to partner with Miss America to align WEN with an organization that goes beyond beauty to promote opportunity and change," said Dean. "The confidence the contestants stand for on stage, on camera and in life offers inspiration and motivation to at-home viewers."
For fans eager to hear an insider's perspective on the pageant, the brand will host a LiveStream conversation with Chaz Dean live from Las Vegas on Saturday, January 14 at 12 p.m. PST. More information on the LiveStream event will be available at https://www.facebook.com/#!/WENhaircare.
Following the pageant, the brand will provide ongoing Miss America related video content through the WEN social channels to give fans a behind-the-scenes view into how to look, act and become more like their favorite Miss America contestants. The WEN Facebook page will include more information and ongoing updates.
"The Miss America Organization is excited to partner with WEN by Chaz Dean. This partnership further underscores the depth and commitment of our sponsors to help support our beautiful contestants that builds on their confidence while supporting our scholarship program," stated Art McMaster, President and CEO of the Miss America Organization.
The 2012 Miss America Pageant airs on ABC Saturday, January 14, 2012 @ 9 p.m. ET. More information about WEN is available at www.wenhaircare.com. WEN is distributed direct to consumers globally by Guthy-Renker LLC.
About WEN
WEN, created by celebrity stylist Chaz Dean, includes the WEN Cleansing Conditioner, designed to cleanse without stripping the hair and scalp of natural oils and does not lather but rather feels like a thick conditioning treatment on the hair. WEN avoids sodium laurel sulfate and other detergents that may be found in ordinary shampoos and is formulated to provide sheen, luster, moisture, manageability and better color retention.
About Guthy-Renker
Guthy-Renker is one of the world's largest and most respected direct marketing companies, with distribution in 68 countries. Since 1988, Guthy|Renker has discovered and developed dozens of well-loved, high quality consumer products in the beauty, skincare, entertainment and wellness categories. Known for moving, award-winning productions and marketing campaigns featuring some of today's leading celebrities, the Company has been credited with transforming the broadcast direct marketing industry. Guthy-Renker has a superior track record of customer satisfaction. Its direct to consumer model allows consumers to purchase products at a guaranteed low monthly price with generous extended return policies.
About Miss America
The Miss America Organization is one of the nation's leading achievement programs and the world's largest provider of scholarship assistance for young women. Last year, the Miss America Organization and its state and local affiliates made available more than $45 million in scholarship assistance. For more information, visit www.missamerica.org.
SOURCE WEN by Chaz Dean: http://www.wenhaircare.com


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Two weeks ago we reported that in the aftermath of the Cambridge Analytica scandal, first Mozilla, then Germany's Commerzbank, and a handful of other smaller companies had suspended their Facebook ad campaigns, as advertisers decided to stay away from the radioactive company, at least until the tempest slamming the social media company faded.
Others were more tentative: ISBA, a British group of advertisers that spends hundreds of millions of pounds a year on Facebook, demanded answers. As The Times reported in March, some of ISBA's 3,000 brands, which include those of the consumer goods companies Unilever and P&G, said they would not tolerate association with Facebook if it emerges that users' data has found its way into the hands of brokers and political campaigners without authorization. Sources close to the trade body said that if the company's answers were not satisfactory, advertisers might spend their money elsewhere.
Two weeks later it appears that decisions whether or not to pull ads remain in limbo, even as - according to Facebook COO, Sheryl Sandberg - "a few" advertisers have paused their spending as they wait for the company to answer questions on user privacy.
"We've seen a few advertisers pause with us and they're asking the same questions that other people are asking," Sandberg said. "They want to make sure they can use data and use it safely."
However, according to Bloomberg, Sandberg said she is having "reassuring conversations with advertisers, just as we are with people," about how Facebook has built privacy into its system.
In a wide-ranging interview, Sandberg discussed the company's shifting responsibilities as it thinks about what can go wrong with its network, following the Cambridge Analytica revelations. She said Facebook is drawing stricter boundaries around its work with certain advertisers and political campaigns, too. The company has worked directly with governments that went on to use the social network against their people, and advertisers that ran anti-Muslim content, for example.
Facebook will continue to work with political advertisers, and will still aim to be "neutral" when assessing content -- just more careful, Sandberg said.
But more importantly for Facebook, and perhaps the best indication that the storm for Zuckerberg & Co. has now passed, DataTrek'c Nick Colas found that the outrage over Facebook is now over. Specifically, Colas was looking at Google search data for "Delete Facebook" since the issues started, and found that the company has not seen any "meaningful impact" in its usage or business. Specifically:
- While searches for the term did spike from March 18 to March 20, they are already most of the way back down to "normal" levels. It has been 18 days since "Delete Facebook" saw a large increase in search interest, and as of this past weekend search volumes were less than half what they were at their peaks in mid March.
- Areas in the US with the most incremental interest in the term are lower-population states such as West Virginia, Montana, Maine, Alaska and North Dakota. Zoom in on high population states such as California, New York and Texas and you will find that "Delete Facebook" searches are entirely back to pre-crisis levels.
- At its peak of Google search interest, "Delete Facebook" was as popular as "Kim Kardashian". Now, Kim is back in the lead with a 2:1 advantage and climbing.
- Also more popular than "Delete Facebook": "Pizza" (65x more), "CNBC" (2x, although it was close for a few days), and "Game of Thrones" (3x, and the show hasn't been on for a while).
Bottom line: unless there are a lot more revelations coming, #deletefacebook is #over.
It also means that for all the advertisers' virtue signalling, and for all Facebook promises that it will change the way it conducts business, just a few weeks after Zuckerberg testifies before Congress next week in yet another kangaroo court which achieves nothing, things will quietly go back to just the way they were, with Facebook collecting billions in "ad" revenue in exchange for selling all of your personal data to the highest bidders.


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Quick Links
Food for Thought
Food for Thought is an app that connects businesses, non-profits, schools and individuals that have excess edible food to those who need it. App users have the option to either share, transport or request food, and can add images to their posts. "Brownie points" gamify the app and create a feel-good factor around sharing.
Approximately 40-percent of food in the U.S. is never eaten, making this country the world's largest food waster. "You assume that because this is a first-world country, there's enough food," said Meghna Natraj, Georgia Tech master's student in Computer Science. "Food's being wasted; it's not being channeled to the right sources."
Atlanta Beltline
Another winning project in the same category uses technology to address gentrification of the area surrounding the Atlanta Beltline. "Concerns about creating a discriminatory environment, rather than universally-available resources are growing," explained the team in their submission video.
The Beltline Display project envisions interactive experiences along the Beltline to promote connected and walkable communities. Utilizing big data, the team proposes creating technology-focused art pieces along the trail to educate users about their surroundings, neighbors and history of the area. The team's goals are to promote social change, foster curiosity, and connect Atlanta communities.
It's been nearly a month since fire engulfed part of I-85 causing it to collapse, and the Georgia Department of Transportation says it could take at least another seven weeks to repair the damage. In the meantime, commuters are exploring alternative means of transportation. The developers of MARTAnow say their app is the perfect use case for solving transit problems.
Even before the I-85 collapse, the team behind MARTAnow has been researching why some commuters are reluctant to use MARTA. They're also trying to solve a larger issue in public transit called the first-mile/last-mile problem – getting people from their location to the bus stop, and from the bus stop to their final location.
"A bridge collapses and all of a sudden, hundreds of thousands of people can't get to where they need to go," said Amit Garg, Georgia Tech master's student in Human-Computer Interaction. "Using our app, people can visualize other modes of transportation to get to their final destination, whether that's ridesharing, through renting a bike, or using MARTA trains and buses."
MARTAnow combines real-time MARTA schedules, walkability scores, and ridesharing into one easy-to-use transit app.
Responsive Letterboard
As many as 40% of people with autism never speak or have difficulty communicating verbally. Rapid Prompting Method, or RPM, was developed by a mother who wanted to teach her non-verbal autistic son to express himself. A group of Georgia Tech students has now found a way to enhance RPM using real-time data.
The process of RPM is simple: a teacher gives a short lesson on a topic, asks a question and then elicits a response using verbal, auditory, or visual prompts. The child will answer based on the teacher's question by spelling out the letters written on a letterboard. The CIC project Responsive Letterboard for Autism Spectrum Disorder reinvents the board. When the child presses a letter, their selection is transferred to a web user interface in real time. This method allows teachers and clinicians to view the data, track a child's progress and make improvements.
The team was inspired by their professor, Gregory Abowd, who has an autistic son. "That community of parents and technicians are really positive and helpful and they're engaged in our research," said Fereshteh Shahmiri, Georgia Tech Ph.D. student in Design Computing
One of the greatest threats to patient safety during an operation is surgical site infection. According to the CDC, in 2011 approximately 157,500 acute care hospital patients were diagnosed with infections.
"Healthcare professionals try their best to prevent this type of infection, but the increasing mortality of surgical site infections has forced professionals to consider every possible way in which the surgical environment can be controlled," said Luka Antolic-Soban, Georgia Tech Computer Science student.
ORCA, or Operating Room Computer Asepsis System, is designed to help operating room professionals detect and prevent contamination during operations. The system has two components. One is a belt that goes underneath surgical scrubs to alert operating room staff when they violate protocol. The other uses a camera and infrared sensor to collect information about the operating room environment, such as the distance between personnel.
The ORCA team is collaborating with Emory University School of Medicine and Children's Hospital of Atlanta to test the system. They've also been invited to participate in Georgia Tech's Startup Launch (formerly Startup Summer), a faculty-led, student-focused program to help student teams launch their startups.


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For more information, contact Ashley Caswell
Greely, the home of generations of talented students and inspiring teachers, is a community - supportive of the arts - past, present & future.
Leaving a Legacy recognizes a talented student: a kindergartener who loves to sing, a 5th grader learning an instrument for the first time, a graduating Madrigal singer, or a Greely Grad who's now on Broadway! It honors a special teacher, an inspirational and supportive family member, or celebrates your love of the arts.
By naming a seat or brick at the Greely Center for the Arts you make a lasting impression. For a one-time, tax-deductible contribution we engrave the inscription of your choice on a seat nameplate or brick in the walkway.
A note regarding the purchase of front row seats:
Front row left and right are sold out; second row middle is considered the front row due to the true front row being removed whenever the orchestra pit is open; naming a seat does not reserve the use of the seat for ticketed performances, orders placed after 10/15/18 will be ordered in the summer of 2019.
Leave a Legacy...
Personalize a seat or brick and become a permanent part of the Greely Center for the Arts.


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About Me
My passion for being out doors has lead me into all types of photography, " Outdoor Portraits, Landscapes, Special Events, Weddings, Wildlife, nature ", I love it all. This is why you will see a variety of images on my page. I love hiking up a mountain in the middle of the night to catch a shot of the milky Way just as much as I love capturing the Bride and Groom on their wedding day.
My husband and I love to travel, so in our spare time we are usually off exploring various parts of the Southeast. if you are into Landscapes and nature, you can find images from our travels on the front of my page.
If you are looking to book a wedding, portrait or an event give us a call, we would love to talk to you. I do not list prices for wedding or events because I find every occasion is unique, i prefer to go over the details and give a price according to your needs.
(770) 313-6912
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Class Information for AHA Heartsaver First Aid CPR AED
Session: Saturday August 24, 2019 09:00 AM at BROOKFIELD:13620 W. Capitol Dr. Ste. D Brookfield, WI
Class Size: 6
# Openings: 2
Class Session Date(s): Saturday August 24, 2019
Registration Dates: 04/01/2016 09:00 AM - 08/24/2019 08:00 AM
Current Price: $95.00
Early Bird Discount: $10.00 if Purchased by 08/24/2019 08:00 AM
The AHA's Heartsaver First Aid CPR AED Course is a classroom, Instructor-led course designed to prepare students to provide first aid, CPR, and use of an automated external defibrillator (AED) in a safe, timely, and effective manner.
Upon successful completion of the course, including a first aid skills demonstration and a CPR and AED skills test, students receive a Heartsaver First Aid CPR AED course completion card, valid for two years.
This course teaches skills with the AHA's research-proven practice-while-watching technique, which allows instructors to observe the students, provide feedback, and guide the students' learning of skills.
This course is for anyone with limited or no medical training who needs a course completion card in CPR and AED use to meet job, regulatory, or other requirements.
Course Content
- First aid basics
- Medical emergencies
- Injury emergencies
- Environmental emergencies
- Preventing illness and injury
- Adult CPR and AED use
- Opioid-associated life-threatening emergencies
- Optional modules in child CPR and AED use and infant CPR
- Optional exam
Session Schedule
|Saturday August 24, 2019
|BROOKFIELD:13620 W. Capitol Dr. Ste. D Brookfield, WI


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Baseball fans are going to find awesome deals today on America's favorite light lagers at LoDo bars and restaurants. Awesome, awesome deals. But if you are looking to drink something else, perhaps a deliciously flavorful ale brewed by one of this state's amazing independent beer makers, you need to have a game plan. Here's a good start:
Blue Moon Brewing @ The Sandlot Although it will be a challenge to get to the bar amid the crush of humanity, the Sandlot brews its own beers right on site, inside Coors Field. In addition to the various Blue Moon seasonals, there will also be a Oktoberfest-style beer and a sour on tap.
Great Divide Brewing The brewery invites you to join the crowds early on opening day -- it'll open at noon -- when the tenders will pour Rockies Real Ale along with fifteen other handles.
Denver Beer Co Celebrating its first-ever opening day, the brewery opens the doors at 10:30 a.m. for pre-game beers. After the game, Uber Sausage will be serving food outside.
Wynkoop Brewing The Wynkoop has been around since before there was a Coors Field. Today the brewpub is offering an all-you-can-eat hamburger and brat buffet for $10 -- not to mention all of their own beers.
River North Brewery This brand-new brewery opened up early today as well and has the Street Eats food truck outside. You can also buy bombers of one of River North's beers to go.
Breckenridge Ballpark Pub Check out the pub -- like the Wynkoop, it predates the ballpark -- which recently underwent a full renovation and remodel. You'll find numerous Breck and Wynkoop beers on tap. Doors opened at 9 a.m.
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Falling Rock Taphouse The beer bar will feature six Odell Brewing beers on the patio today, including Myrcenary Double IPA and Double Pilsner.
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Ref. 722
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Also for investors a unique opportunity!


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EBV infection is inversely associated with IgE sensitization in children, and this association is further enhanced by CMV coinfection. In mice, herpesvirus latency causes systemic innate activation and protection from bacterial coinfection, implying the importance of herpesviruses in skewing immune responses during latent infection. Early control of viral infections depends on IFN-γ release by NK cells, which generally requires the presence of accessory cells. We investigated IFN-γ production by NK cells in PBMCs from children seropositive (SP) for EBV alone, for both EBV and CMV, or seronegative for both viruses. The ability of classical (CD14++CD16−) and proinflammatory (CD14+CD16+) monocytes to induce autologous NK cell IFN-γ was studied by coculture experiments with enriched CD3−CD56+ cells. Transwell experiments were used to evaluate how monocytes interact with NK cells to induce IFN-γ synthesis. SP children had a significantly reduced proportion of IFN-γ+ NK cells and cognate intracellular IFN-γ levels, which was more pronounced in CMV-coinfected subjects. Also, resting PBMCs of SP children displayed lower proportions of proinflammatory monocytes. IFN-γ production by NK cells was dependent on interactions with monocytes, with the proinflammatory subset inducing the highest IFN-γ. Finally, SP children had markedly lower levels of plasma IFN-γ, concurrent with in vitro findings. Herpesvirus infections could be one contributing factor for maturation toward balanced Th1-Th2 responses. Our data indicate that early infection by herpesviruses may affect NK cell and monocyte interactions and thereby also influence the development of allergies.
The viruses EBV and CMV belong to the herpesvirus family and are widely spread in human populations. Primary infections with EBV and CMV often occur during early childhood and are usually asymptomatic or mild. After primary infection, EBV and CMV establish latency and persist for the lifetime of the host. Seropositivity for these viruses can vary among populations dependent on their socioeconomic background, and young children in industrialized countries seem more protected from early infection (1, 2). Latently infected memory B cells are believed to constitute the main site for EBV persistence (3), whereas the location for carriage of CMV DNA is less clear but has been shown to include cells of the myeloid lineage (4).
Because Ag-specific immune responses require time to develop and expand, components of innate immunity play an important role in the early phase of infections. NK cells are activated early after a viral infection, and one of the central mechanisms by which they mediate antiviral activity is through IFN-γ. This cytokine is a potent activator of APCs by influencing their maturation and antiviral functions (5, 6). IFN-γ can also act as an immunoregulatory cytokine in that it plays a central role in the shaping of Th1 immune responses (7).
Although NK cells can exert immediate attacks, they generally do not become fully functional unless triggered by cytokines that are released upon recognition of viruses or viral components (6). Among these cytokines are the proinflammatory ILs, IL-12, IL-15, and IL-18, which are produced largely by accessory cells, such as dendritic cells (DC)5 and monocytes (5, 6, 8, 9). In addition to soluble factors, NK cells can become activated by a number of contact-dependent mechanisms provided by accessory cells, and numerous studies have investigated such interactions between NK cells and DCs (10, 11, 12).
NK cell and monocyte interactions have received less interest, although it has been demonstrated that depletion of CD14+ cells markedly reduces IFN-γ production by NK cells (13, 14). In addition, blocking of the costimulatory molecules CD40 (15), CD80, and CD86 (16) on activated monocytes has been shown to decrease NK cell IFN-γ production. However, distinction of monocytes on the basis of CD14 expression alone might not be optimal for examining their interactions with other cells, given that monocytes represent a heterogeneous population with functional differences. Monocytes are roughly divided into two major subsets and are classified based on differential expression degrees of CD14 and CD16 (FcγRIII). The larger subset is CD14++CD16− (classical monocytes), whereas the remaining subset is CD14+CD16+ (nonclassical or proinflammatory monocytes) (17, 18). Proinflammatory monocytes express higher levels of MHC class II and CD86 (17, 18) and are more likely to differentiate into DCs (19). They also produce larger amounts of proinflammatory cytokines and lower IL-10 compared with classical monocytes (20, 21). Alternatively, CD14+CD16+ monocytes are suggested to be the precursors of resident myeloid cells in noninflamed tissues (22), and activated DCs derived from human CD16+ monocytes seem to preferentially promote Th2 responses (23, 24).
Our group has previously reported an inverse association between EBV seropositivity and IgE sensitization in 2-year-old children, which seems to be augmented by the presence of CMV coinfection (25). When investigating plausible mechanisms behind this protection in the T cell compartment, an overall increased cytokine production in PHA-stimulated PBMCs in EBV-seropositive (SP) 2-year-old subjects was observed, whereas CMV infection was associated with a bias toward a Th1-type cytokine profile (26). This would suggest that both EBV and CMV could influence the early life development of functionally diverse adaptive immune responses.
Innate responses can greatly influence the generation and maintenance of subsequent adaptive effector functions (27, 28). A recent study in mice demonstrated that latency with herpesviruses is associated with increased levels of circulating IFN-γ and a stronger macrophage activity (29). However, corresponding data on humans are lacking. The objective of this study was therefore to examine innate responses in relation to EBV and CMV seropositivity in 2-year-old children. We have studied monocyte-induced NK cell IFN-γ production in PBMCs of children with a positive or negative serostatus for these herpesviruses and demonstrate that seropositivity associates with decreased production of IFN-γ by NK cells, lower IFN-γ levels in plasma, and a lower proportion of CD14+CD16+ monocytes.
Materials and Methods
Characterization and serostatus of subjects
A total of 51 IgE-nonsensitized 2-year-old children (Table I⇓) were selected from an earlier described family cohort (25). The presence of serum IgG against EBV capsid Ag was determined according to previously published immunofluorescence assays (30) where a specific fluorescence at a dilution of 1/20 was regarded as a sign of seropositivity. IgG seropositivity to CMV was determined by ELISA using purified nuclear Ags from CMV cultivated in human fetal lung fibroblasts (31), where samples with an OD >0.2 at a dilution of 1/100 were considered positive. Subjects were divided into two groups, one group with children that were seronegative (SN) for both EBV and CMV (n = 26) and the other group (n = 25) with subjects SP for either EBV alone (n = 16) or both EBV and CMV (n = 9). Further, buffy coats from healthy adult blood donors were obtained from the blood bank at Karolinska University Hospital (Stockholm, Sweden). This study was approved by the Human Ethics Committee at Karolinska University Hospital (Huddinge, Sweden) and Karolinska Institutet, and the parents provided their informed consent.
Separation of plasma and mononuclear cells from blood, cell isolation, and culture
Following collection of venous blood, plasma was separated after centrifugation and stored at −70°C. PBMCs were isolated by Ficoll-Paque (Pharmacia-Upjohn) gradient centrifugation and cryopreserved in liquid nitrogen. For the in vitro experiments, PBMCs were thawed, then washed twice in RPMI 1640-HEPES (Life Technologies), and resuspended in RPMI 1640 supplemented with 10% heat-inactivated FCS (HyClone Laboratories), l-glutamine (2 mM/L), penicillin G sodium (100 U/ml), and streptomycin sulfate (100 μg/ml; Merck) to a concentration of 106 Staphylococcus aureus; Fluka; Sigma-Aldrich) or IL-15 and PGN in combination. Supernatants were stored at −85°C until analysis. Where indicated, CD3−CD56+ NK cells, CD14+ monocytes or subpopulations of monocytes (CD14++CD16− and CD14+CD16+) were separated from PBMCs of healthy adult donors, using MACS isolation kits according to the manufacturer's instructions (Miltenyi Biotec). Enriched monocytes and autologous NK cells were cultured alone or cocultured with or without transwell inserts (ratio, 1:1; Corning) and treated with either medium or a combination of IL-15 and PGN, as described above, during 24 or 44 h.
Flow cytometry
FITC-, PE-, PerCP-, or allophycocyanin-conjugated or biotinylated mAbs were used for cell staining of CD3, CD56, CD16, CD14, CD11c, CD80, CD86, and IFN-γ according to standard procedures. The biotinylated primary Abs CD80 and CD86 were used in combination and detected with streptavidin-PerCP conjugate. To detect intracellular IFN-γ, GolgiStop was added during the last 4 h of incubation. After surface labeling, cells were fixed, permeabilized, and stained for IFN-γ. Data were acquired and analyzed with a FACSCalibur flow cytometer and CellQuestPro version 5.2.1 software, all from BD Biosciences. Intracellular IFN-γ levels are presented as geometrical mean fluorescence intensity (GeoMFI) values.
IL-6, IL-10, IL-12p70, IFN-γ, and TGF-β ELISA
To determine IL-6, IL-10, IL-12p70, and IFN-γ concentrations in cell supernatants or in blood plasma; Abs against IL-6, IL-10, IL-12p70, and IFN-γ (Mabtech); human rIL-6, rIL-10, rIL-12p70, and rIFN-γ (National Biological Standards Board); streptavidin-alkaline phosphatase-conjugated Abs (Mabtech); and p
Statistical analysis
The Mann-Whitney U test or Fisher's exact test was used to evaluate differences between sample groups. Cuzick's nonparametric test was used to evaluate trends. Outliers are not shown in figures. Data in the text indicate median (numbers in parentheses, range). Statistical analyses were performed with Statistica 7.1 (Statsoft) and Stata 8 Software (Stata) at the Division of Mathematical Statistics (Stockholm University, Stockholm, Sweden). p values below 0.05 were considered statistically significant.
Herpesvirus seropositivity is associated with decreased IFN-γ production by NK cells
The IFN-γ production capacity was examined in 2-year-old subjects, either SP for EBV, EBV and CMV or SN for both viruses. PBMCs were stimulated in vitro for 24 h with IL-15 or PGN or with IL-15 and PGN in combination and stained for intracellular IFN-γ. The flow cytometric analysis showed that only a combination of IL-15 and PGN induced effective IFN-γ production. NK cells represented the major IFN-γ+ cell population (Fig. 1⇓A), whereas only very low proportions of IFN-γ+CD3+ cells were detected (Fig. 1⇓B).
The SP group of children had a significantly lower proportion of IFN-γ+ NK cells among total NK cells (p = 0.019; Fig. 1⇑C) accompanied by decreased levels of intracellular IFN-γ measured as GeoMFI (p = 0.035; Fig. 1⇑D) after stimulation with IL-15 and PGN than did SN children. When SP subjects were further divided into EBV+CMV− and EBV+CMV+ subgroups, CMV coinfection was associated with the lowest fraction of IFN-γ+ NK cells (p = 0.011, Fig. 1⇑E) and the lowest levels of intracellular IFN-γ (p = 0.010; Fig. 1⇑F). This pattern was also observed for IFN-γ detected by ELISA in culture supernatants (p = 0.039; Fig. 2⇓), although no significant differences were found when dividing the children only according to their positive or negative serostatus (p = 0.072; data not shown).
SP and SN children did not differ in NK cell IFN-γ production after 24 h of culture in medium alone neither in the proportion of IFN-γ+ NK cells (1% (0–1) and 1% (0–1), respectively) nor in intracellular levels of IFN-γ, measured as GeoMFI, (8 (6–18) and 8 (6–31), respectively). IFN-γ+CD3+ cell proportions did not differ between SP and SN children (medium alone: 0% (0–1) and 0% (0–1), respectively; IL-15 and PGN: 2% (0–27) and 3% (0–67), respectively), nor did the CD3+ IFN-γ levels measured as GeoMFI (medium alone: 8 (6–12) and 8 (6–11), respectively; IL-15 and PGN: 9 (7–19) and 9 (7–21), respectively). There were no significant differences between SP and SN children regarding total NK cells of all lymphocytes (5% (2–21) and 5% (2–12), respectively), CD56bright cells of all NK cells (4% (2–13) and 4% (1–11), respectively), or total CD3+ cells of all lymphocytes (78% (39–86) and 77% (50–88), respectively) after 24 h in medium.
Herpesvirus seropositivity associates with phenotypically altered CD14+CD16+ monocytes
Next, we wanted to examine if herpesvirus seropositivity also affected monocyte characteristics. There was a clear tendency toward a decreased ratio of CD14+CD16+ monocytes after 24 h in medium in SP compared with SN children (p = 0.058; Fig. 3⇓A), although no differences were detected upon IL-15 and PGN stimulation (data not shown). When further assessing the phenotype of the CD14+CD16+ subset, we found that CD11c expression on CD14+CD16+CD80/CD86+ monocytes was significantly lower in SP children after 24 h in medium alone or with stimulation (p = 0.042 and p = 0.003, respectively; Fig. 3⇓B).
To assess monocyte function, a set of mainly monocyte-derived cytokines was measured in cell culture supernatants. There were no significant differences in IL-6 release in culture supernatants between SP and SN children (data not shown), although there was a tendency for the EBV+CMV+ children to produce the lowest amounts of IL-6 after stimulation, in analogy with the results for IFN-γ. There was a positive correlation between the supernatant IL-6 and IFN-γ levels after challenge (rs = 0.66; p < 0.001). There were no differences in IL-10 or TGF-β levels between the groups (data not shown), and the levels of IL-12p70 in cell culture supernatants were below the detection limit of our assay.
NK cell IFN-γ production is more potently induced by CD14+CD16+ monocytes
Given that the proportion of CD14+CD16+ monocytes was reduced in SP children, we wanted to address their potential contribution to the observed NK cell IFN-γ responses. Consistent with previous findings (13, 14), substantial IFN-γ levels in the culture supernatants were detected only in stimulated cocultures of CD14+ cells and NK cells, whereas stimulation of either cell type alone resulted in barely detectable levels of IFN-γ (Fig. 4⇓A). In addition, IFN-γ levels detected in monocyte and NK cell cocultures were comparable with those detected in PBMC cultures (Fig. 4⇓A), indicating that the monocyte is the main NK cell-activating cell type among PBMCs. We observed markedly higher levels of IFN-γ in cocultures of NK cells and CD14+CD16+ monocytes, as compared with NK cell cocultures with CD14++CD16− cells (Fig. 4⇓B). In agreement with other studies (13, 14, 15, 16, 32), when enriched monocytes and NK cells were cocultured but separated by transwell inserts, the levels of IFN-γ were decreased, indicating that cell-to-cell contact was required for optimal IFN-γ production by NK cells (inhibition range, 40–55% from three separate experiments).
Herpesvirus seropositivity in children is associated with reduced levels of plasma IFN-γ
We further investigated whether the observed in vitro differences in IFN-γ production between the groups of children were evident also in vivo and determined plasma IFN-γ levels. In accordance with our in vitro results, we found significantly lower levels of circulating IFN-γ in the plasma of the SP children (p = 0.048, Fig. 5⇓A). Again, the same pattern was found when the SP subjects were subgrouped in which CMV coinfection was associated with the lowest IFN-γ levels (p = 0.015; Fig. 5⇓B). We also quantified IL-6 in plasma but found no significant differences between the groups. Similarly to culture supernatants, there was a strong correlation between plasma IFN-γ and IL-6 (rs = 0.90; p < 0.001).
Throughout the process of virus-host coevolution, herpesviruses have developed an array of immunomodulatory mechanisms to avoid detection and destruction by the host's immune system. Although loss of immune control can lead to herpesvirus reactivation from latency and result in serious disease (2, 3, 4), delayed primary infection with herpesviruses in affluent societies (1, 2) coincides with higher incidence of allergic disorders (32), which in contrast indicates a beneficial role for these viruses.
In connection with this, our group has previously reported an inverse association between EBV seropositivity and IgE sensitization in 2-year-old children (25). Recent observations from our laboratory did not provide support for a Th1-biased cytokine profile in EBV SP children (26), which could have explained the protection against the allergic phenotype (32, 33). However, latent herpesvirus infections in mice result in potentiated innate activity and increased systemic IFN-γ levels (29). To elucidate the mechanism behind protection against IgE sensitization in SP infants, we focused on monocyte and NK cell interplay given that their interaction has been suggested to play a role in the early control of viral infections and might be important for the initiation and shaping of subsequent adaptive responses (10, 12).
The cooperation between accessory cells and NK cells has recently been investigated in relation to diseases such as malaria (13, 14), rheumatoid arthritis (34), atopic dermatitis (35), and respiratory allergic disorders (36). To our knowledge, we are the first to examine monocyte-induced IFN-γ synthesis in NK cells in relation to early life viral infections. We demonstrate that EBV seropositivity in infants is associated with reduced monocyte-induced NK cell IFN-γ production, with regard to both the proportion of IFN-γ+ NK cells and to their cognate intracellular IFN-γ levels. This reduction was even more pronounced in children who were SP for both EBV and CMV. Data on intracellular NK cell and cell culture IFN-γ paralleled, which strongly argues against different kinetics in the synthesis of this cytokine between the groups. The activation degree of CD14+ cells after PGN challenge has been shown to correlate with released IL-6 (37). Interestingly, a strong correlation was found between IL-6 and IFN-γ levels in culture supernatants after stimulation although no differences in IL-6 levels were seen between the groups.
PBMCs from SP children showed a strong tendency toward a lower proportion of proinflammatory monocytes. When assessing their functional properties, we found that they triggered IFN-γ release by NK cells more potently than classical monocytes. This effect could potentially be due to an increased capacity to secrete IL-12 (38), which is a key inducer of IFN-γ responses (39), but levels of IL-12p70 in cell culture supernatants were below the detection limit of our assay. The lower CD14+CD16+ ratio in SP children could not be explained by decreased production of TGF-β or IL-10, cytokines that have been shown to induce CD16 expression on monocytes (40, 41). However, we cannot rule out that the EBV and CMV encoded homologs of human IL-10 could have affected the quantification of IL-10 in plasma (42). To our knowledge, IFN-γ has no clear involvement in regulation of CD16 on monocytes (43, 44). Furthermore, NK cells can be regulatory by killing immature DCs (45) or overactivated macrophages (46), but whether preferential elimination of the CD14+CD16+ cells could be an explanation behind decreased proportions in SP children remains to be elucidated.
Interestingly, plasma IFN-γ levels in SP children were significantly lower than in their SN counterparts, concurrent with our in vitro data. Again, CMV coinfection was associated with the lowest levels of IFN-γ. The reason behind this finding is unknown but is indicative of in vivo interactions between EBV and CMV with immunomodulatory consequences, something which is supported by a study from Aalto et al. (47) showing that primary CMV infection induced reactivation of latent EBV. Thus, in the double-positive children, CMV coinfection may intensify EBV-induced immune scarring. Furthermore, IL-6 and IFN-γ levels correlated, suggesting a possible in vivo monocyte and NK cell interaction. The fact that the NK cell IFN-γ production in vitro and plasma levels of IFN-γ paralleled could imply that NK cell-derived IFN-γ was the major source of IFN-γ in plasma. Indeed, T cells are also important in controlling viral infections (48), but here their contribution to the plasma IFN-γ is unclear. However, because the SP subjects had lower IFN-γ in their plasma, and we have observed an overall increased cytokine production by PHA-stimulated PBMCs from SP children (26), this strongly argues against T cells as the major contributors to the differences in plasma IFN-γ between the groups.
A modulated accessory cell function due to herpesvirus infections may influence NK cell IFN-γ responses in SP subjects. For instance, infection of monocyte-derived DCs with CMV (49) and HSV 1 (50) inhibits their maturation process as well as their release of inflammatory cytokines. Ex vivo data obtained here from SP infants strengthens these findings and suggests that reduced proportions of CD14+CD16+ cells might play a part in attenuated NK cell IFN-γ responses after pathogen encounter. In a model of transendothelial trafficking, CD14+CD16+ cells showed a higher likelihood to differentiate into DCs (19); suggesting that they could represent physiologically relevant blood precursors of migrating DCs, with the potential to interact with NK cells at sites of inflammation or in secondary lymphoid tissues (51). In addition to the decreased ratio, CD14+CD16+ monocytes from SP subjects who displayed an activated phenotype expressed lower levels of CD11c, implying that a modulation of migratory behavior might occur (52).
Exposure to pathogenic and nonpathogenic agents in childhood strongly influences the progressive shift from the allergy-related Th2 profile toward a balanced Th1-Th2 immunity (33). At first sight, the present data seem difficult to reconcile with our previous data of a high cytokine production in SP children (26). Intriguingly, the two studies indicate that EBV and CMV seropositivity is associated with a lower NK cell but higher T cell cytokine response. A viral-induced modified balance between monocytic subsets might be one possible explanation behind this observation.
The finding of lower plasma IFN-γ in SP children was unexpected since recent findings in mice with herpesvirus latency suggested the opposite (29). Besides, acute EBV infection in adults causes mononucleosis, which is accompanied by higher in vivo IFN-γ (53) and increased NK cell activity (54). Whether dampened innate responses in infants are a consequence of herpesvirus infection, or may cause higher susceptibility to infection, remains an open question. A differential predisposition for acquiring infections might exist (55, 56), and a very potent innate reaction toward viruses could hypothetically block active infections and preclude adaptive immune responses. Because additional data in favor of this hypothesis is lacking, we rather speculate that herpesvirus infections attenuate innate responses in small children, which could explain why they typically have asymptomatic primary infections. Indeed, it would have been interesting to determine at which stage of viral infection this innate suppression takes place. This is difficult, however, given that the relation between development of humoral responses and infection time in asymptomatic infants is not established.
The fact that a number of the 2-year-old subjects were still SN could also reflect differential exposure to viruses. However, there were no differences between the groups in exposure factors such as duration of breast-feeding, number of siblings, or day-care attendance (Table I⇑).
In summary, we speculate that early life infection by herpesviruses may attenuate innate responses with particular influence on monocyte-NK cell interactions, with possible implications in the development of allergies.
A special thanks to Monica Nordlund, Anna Stina Ander, and Ann Sjölund for their valuable assistance and to Jan-Olov Persson for performing statistical analyses.
The authors have no financial conflict of interest.
The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
↵1 This work was supported by Swedish Research Council Grants 74X-15160-03-2, 57X-15160-05-2, and K2006-74X-15139-03-02); European Union Grants LSHP-CT 2004 and 503578; the Vardal Foundation; the Swedish Asthma and Allergy Association's Research Foundation; the Swedish Medical Society; and the Golden Jubilee Memorial, Crown-Princess Lovisa and Axel Tielman, Golje, Hesselman, Åhlén, and Apotekare Hedberg foundations.
↵2 Address correspondence and reprint requests to Dr. Shanie Saghafian-Hedengren, Stockholm University, Department of Immunology, Svante Arrheniusväg 16-18, 106 91 Stockholm, Sweden. E-mail address: shanie{at}imun.su.se
↵3 Shared first authorship.
↵4 Shared last authorship.
↵5 Abbreviations used in this paper: DC, dendritic cell; PGN, peptidoglycan; SN, seronegative; SP, seropositive; GeoMFI, geometrical mean fluorescence intensity.
- Received May 27, 2008.
- Accepted December 13, 2008.
- Copyright © 2009 by The American Association of Immunologists, Inc.


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I have attached a link to a great song to use when teaching action verbs! My children are addicted to this song. Be prepared though...you won't be able to get it out of your head either!
3 weeks ago
I love this! That is awesome!! Thank you!ReplyDelete
I found the Verb Rap by accident when surfing the web looking for a verb unit. I bought cheap sunglasses from Oriental Trading for the class, and the the kids were "styling and profiling" as they sang and looked cool! They were able not only to learn about action verbs, but were able to showcase their dancing talents. This song really comes in handy if the students are a little drowsy after lunch. All I have to do is say, "Get out your sunglasses" and they are ready to go and perk right up!ReplyDelete
Thanks for posting about my Verb Rap Song! Your blog is awesome :) -Mark from Have Fun TeachingReplyDelete
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Kirsten Kirchner
Kirsten graduated from Oklahoma State University with a Bachelors in Animal Science with a Production option. She has also completed and Paralegal Certification course through Oklahoma State University.
Kirsten was raised in Sherman, Texas and after high school graduation she went to OSU where she met her husband, Mark. They were married after graduation from OSU and moved to Clovis, NM where Mark worked for Cargill and Kirsten work at a vet clinic. After ten months in Clovis they moved to Kingfisher, OK where Mark began working for CHS and Kirsten for BancFirst. Kirsten started working at Harrison & Mecklenburg, Inc. in February of 2013. She specializes in lease cancellation cases and title exams but is branching out into other areas of legal work.
Kirsten and Mark have a son named Ethan and three dogs. They enjoy watching all OSU sporting events and spending time outdoors exploring and cooking.