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All-Academic Captains excel in dual arenas
San Diego Section's best of the best in the classroom, on the field
The high school boys tennis team championships generally fall during the same window as AP testing. In past years, three-time Westview captain Rae Lan would take an Advanced Placement test in the morning and play a postseason match in the afternoon.
This year, when it was announced that the AP test date landed squarely on the day of the team tournament finals, Lan rescheduled it. As luck would have it, the rescheduled test date was on the same day as the San Diego Section singles tournament.
Last year, the National Merit Finalist, National AP Scholar and all-section first-team selection reached the singles semifinals. He was expected to contend this year. Lan was hoping to juggle AP testing and tennis again, but he was forced to default in the quarterfinals when the AP Chinese test was delayed by about 2 hours because of technical difficulties. The delay made it impossible for Lan to finish in time to make his match.
"It's a bit disappointing since I reached the semifinals last year, but it happens," he said.
Lan, who carries a 4.55 grade-point average and scored 2,370 on the SAT, has taken 15 AP courses. He earned a full academic scholarship to USC, where he'll study computational neuroscience and continue his tennis career as a walk-on. Lan is considering a career as a surgeon.
"I want to make a tangible difference for the people around me," he said.
Lan has been selected as one of 13 San Diego Union-Tribune All-Academic Team Captains for spring sports. The Captain's plaque represents each sport's Academic Athlete of the Year. In Sunday's editions, the Union-Tribune recognized 7,790 high school juniors and seniors as members of the All-Academic Team for maintaining a 3.0 or higher cumulative, weighted GPA while playing a
Girls lacrosse:
Brooke Greene, Otay Ranch
Balancing sports and academics can produce some challenging choices. The Metro Mesa League Player of the Year and National Honor Society member said she had a teacher who disapproved when Greene had to leave early to catch the team bus. "He thought I was choosing (sports) over education," said Greene, whose accomplishments indicate otherwise. Greene, who helped lead the Mustangs to a section title in girls lacrosse, has a GPA of 4.34 and is taking six AP courses. When the junior isn't playing lacrosse, she is tutoring football players in math. She plans to study finance or math in college to prepare for a career as an accountant or actuary.
Boys lacrosse:
Jake Fiske, Poway
When the 5-foot-10, 160-pound midfielder was a freshman, he looked like he still belonged in middle school. In fact, Fiske, who volunteers at food-packing events for the hungry, was encouraged to pack on a few to his 120-pound frame. He proved that size doesn't matter, work ethic does. He earned a starting spot on the varsity lacrosse team his first year, led Poway to back-to-back section titles and was named 2015 Player of the Year. The All-American has a 4.17 GPA, scored a 2,010 on the SAT and earned academic and athletic scholarships to Bryant in Smithfield, R.I., where he plans to major in business.
Mikaila Reyes, Torrey Pines
Over her four-year varsity career, Reyes has played all nine positions. She was recruited as a utility player and committed to
Calvin Farris, Grossmont
When he was 12, this Navy kid lived in Italy and played for a baseball team that won a national championship. This experience solidified his love for the game and put him on an upward trajectory. The 6-foot-1, 205-pound pitcher (6-0/1.09 ERA) and outfielder with a .374 batting average will continue playing at Brown in the Ivy League. Farris, who has a 4.24 GPA, may join Brown's Business, Entrepreneurship and Organizations pathway and its Humanitarian Assistance program. He has volunteered for the EOD Wounded Warriors Foundation. "The lessons I learned about sacrifice have stuck with me to this day," he said.
Girls track and field:
Nia Akins, Rancho Bernardo
She once chose the road less traveled — and everybody followed. It was Akins' junior year. The multisport athlete was competing in the section cross country championships when she picked the wrong route. But she was leading, so the field followed. She won on the impromptu-redesigned course for her second cross country title. Akins, who has taken seven AP courses and four honors courses, three-peated as the 800-meter champ and is the school record holder. RB's Female Athlete of the Year has a 3.95 GPA and will continue her athletic career at Penn to study nursing.
Boys track and field:
Matthew DeRoos, Tri-City Christian
During a meet, the two-time Pacific League Track Athlete of the Year initiated the clap — hyping the crowd into rhythmic clapping — prior to his long jump takeoff into the pit. But DeRoos hit the board, slipped forward and face-planted. "Would have been a big jump if everything went right," lamented DeRoos, who finished fifth in the state in the long jump last week. The TCC Athlete of the Year, who has a 4.55 GPA, is considering UCLA, USC and Stanford to continue athletics and study architecture and possibly engineering. DeRoos has volunteered at summer camps and soup kitchens.
Girls swimming:
Sarah Nowaski, West Hills
The West Hills scholar-athlete is headed to Rice in Houston. Nowaski, who earned a partial athletic scholarship, carries a full load of AP courses and has a 4.67 GPA. She plans to major in either biochemistry or chemistry en route to becoming a doctor. The four-year honor roll student and four-year 500-freestyle section winner set All-America times her freshman, junior and senior years. She earned section Swimmer of the Year honors last year. Nowaski volunteers her time teaching kids to swim.
Boys swimming:
Sukhman Singh, Carlsbad
The back-to-back section champion in the 100 butterfly and 100 backstroke wants to study the brain and become a neurologist. Oddly, he has concluded that quickly slapping his own head six times before each swim race helps him focus. "Most find this routine weird, but it lets my mind know it's go-time," said Singh. When the junior, whose GPA is 4.33, isn't swimming or studying for his six weighted classes, he's volunteering at a senior center. He has witnessed the effects of
Audrey Chan, La Jolla
The section girls champion is taking five weighted classes this year. The bilingual junior, who has a 4.05 GPA, graduated last year from the San Diego Chinese Academy after 12 years. She has also completed four years of Latin, including AP. Chan is leaning toward a path in the medical field, possibly in sports medicine. She hasn't decided on a college yet but would prefer to attend a UC school. While Chan would like to play badminton in college, she will be limited to a club team. To Chan's chagrin, badminton was dropped from the NCAA's emerging sports list in 2009.
Boys volleyball:
Devin Pontigon, El Camino
He broke the El Camino record for kills in a match with 40. He broke the school record for kills in a season with 626. But the more impressive number for the all-section pick is the 135 volunteer hours Pontigon has contributed to various causes. Volunteering has "made me realize that many families and individuals rely on the community," he said. The future UC San Diego biochemistry major with premed ambitions plans to walk on to the volleyball team. The three-year captain and four-year El Camino scholar-athlete has a 4.3 GPA. Pontigon led El Camino to a section boys volleyball title.
Carter Clatterbuck, Mt. Carmel
She returned to gymnastics after a four-year layoff due to multiple heel fractures. She won the section optional all-around title as a junior and was named the 2015 Gymnast of the Year. This year, she won the optional all-around Sundevil Invitational title. Clatterbuck is headed to Texas Christian, where she'll be exclusively a student, studying biology on a premed track. She earned the Dean's Scholarship worth $20,000 per year and was accepted to the TCU Honors College. The Mt. Carmel Scholar Athlete of the Year has a 4.09 GPA and scored a 31 on the ACT.
Boys golf:
Noah Henderson, Torrey Pines
The Torrey Pines senior, ignoring pain in his lower extremity, played the entire 2014 season with three fractured bones in his left foot. After a six-week layoff, Henderson qualified for the Junior Worlds and the U.S. Junior Amateur. He tied for fifth in the section tournament this spring and helped boost the Falcons to a state title. He volunteers his time as an instructor at junior golf events. Henderson, who has a 4.06 GPA and scored a 32 on the ACT, has been offered several academic scholarships. He is considering Kansas, George Washington and Saint Joseph's to play golf and major in international affairs. He would like to pursue a career in law or government, specifically the CIA.


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Olympiad Gymnastics in Chesterfield, MO provides gymnastics instruction for girls and boys ages toddler through teens. We also offer summer camp, birthday parties, cheerleading classes and private lessons.
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12675 Olive Blvd, Saint Louis, MO
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subset: commoncrawl


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On Sale
Redcurrant Jelly
What Am I?: The perfect condiment to have on hand at all times. Pairs with: A variety of meats and cheeses. An excellent way to add a flavour or even to elaborate sauces.
Please note, we are experiencing higher order volumes than usual. We're doing our very best and appreciate your support during this time. For expected wait times, please see our Delivery Info section.
For same-day service, we invite you to shop with us in-store!


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Angel Almendros, of City University in Hong Kong, told BBC News: "There is not a single case of a pet dog or cat infecting a human being with COVID-19".
To avoid any risk of pets carrying the virus from the hands of the owners, the president of the British Veterinary Association (BVA), Daniella Dos Santos, encouraged the owners to take "sensible precautions".
She said: "Practice good hand hygiene, try to keep the cats indoors.
"Avoid unnecessary contact with your pets, hugging or licking your face and don't touch other people's dogs while walking."
Angel Almendros, in a recent article on the subject, cited the case of a 17-year-old pet dog in Hong Kong who tested positive for COVID-19.
Thought to be infected by its owner, the dog was later released from testing after being released from the virus.
Shortly after its release, the dog died tragically, probably as a result of the stress induced by the testing process, the Hong Kong vets said.
Almendros said: "But even where we have these positive results, animals are not getting sick.
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More recently, there have been reports that tigers at the Bronx Zoo in New York he had contracted the virus from a worker carrying the virus, but he was asymptomatic.
"It is interesting to note in the experimental evidence that cats can be infected, in addition to the apparent infection of a tiger," said Bryan Charleston, director of the Pirbright Institute in the UK, which specializes in the study of infectious diseases.
All of this led "evidence of transmissibility" to build a solid case.
In addition, there is also evidence that humans can transmit respiratory infections to large wild monkeys.
This makes the global spread of the virus a particular concern for conservationists working to protect endangered wildlife around the world.
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In all the cases mentioned, infected humans are the animals that pose the greatest threat to other species.
Professor Charleston said: "We know that the virus jumped from an animal to a human (at the beginning of this crisis), but that seems to be because people were eating these infected animals."
Relating the information to cats, the British Veterinary Association draws attention to how an animal's fur can transmit the virus for a time "if a pet comes into contact with someone who is sick".
So, advice to keep pets indoors for the near future.
Almendros recommended: "Treat pets like other people in your home.
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"So, if you're feeling sick, you better not interact with them."


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Analytics of petrochemical markets
Our Clients
MOSCOW (MRC) -- In August, Russian
makers reduced PVC output by 15% from July to 40,700 tonnes. The year-to-date
total PVC production in Russia made about 410,000 tonnes, report MRC
analysts.Russian producers expectedly slashed PVC production in August
on scheduled outages at SayanskKhimPlast and Kaustik (Sterlitamak) - two
major producers. Last month the total PVC production made about 40,700 tonnes,
down 15% from July.
Kaustik (Sterlitamak), the second largest PVC producer in the Russian
Federation, has shut its suspension PVC production for a two-week turnaround
from July 17. The annual capacity of the plant makes 180,000 tonnes. The PVC
production had been resumed by August 4. In August, the production volume made
about 15,400 tonnes. SayanskKhimPlast began its outage for a four-week
maintenance in mid-August. In August, the facility managed to produce about
12,400 tonnes of suspension PVC. The output of PVC at Kaustik (Volgograd) and
SIBUR-Neftekhim remained without any significant changes last month compared to
July.The only producer of emulsion PVC in Russia - Khimprom
(Volgograd) manufactured in August slightly more than 2,900 tonnes of
the resin.A significant growth of PVC production from Russian
makers is not expected in September. SayanskKhimplast resumed the resin
production only at the end of last week after the outage for a scheduled
maintenance. Kaustik (Sterlitamak) shut its production twice in September
following the problems at the ethylene pipeline. At the end of last week the
plant resumed PVC production, but not with 100% capacity utilization. According
to unofficial information, Kaustik (Sterlitamak) is going to work with the
reduced capacity utilization till late September due to restrictions in ethylene
In general, over the past eight months the total PVC production by
Russian producers made about 410,000 tonnes, up 11% year-on-year. The production
volume of suspension PVC grew by 11% and made about 395,000 tonnes. The main
increase of production volumes was due to Kaustik (Sterlitamak) and
SayanskKhimPlast. The output of emulsion PVC decreased by 4% to 14,100


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Make way
Make Way: Today I want to get you pumped up! I want to get you fired up and ready to fly! Did you…
Andrej Pejic
Andrej Pejic for Oyster Mag | Photography: Jez Smith@ Vivien's Creative
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Sasha Marini | ph: Errikos Andreou | via YVY
Mugler by Nicola Formichetti Menswear F/W 11.12 Show
Mugler by Nicola Formichetti Menswear Fall/Winter 11.12 show in Paris


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Category: Kitchen & Dining | Last Updated: 2019-09-15 03:55:07 by Melyssa Durgan
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A novel mechanism in wound healing: Laminin 332 drives MMP9/14 activity by recruiting syndecan-1 and CD44 Matrix Biol. (IF 8.572) Pub Date : 2020-07-02 Anna Michopoulou; Marine Montmasson; Cécile Garnier; Elise Lambert; Guila Dayan; Patricia Rousselle
Re-epithelialization describes the resurfacing of a skin wound with new epithelium. In response to various stimuli including that of growth factors, cytokines and extracellular matrix (ECM), wound edge epidermal keratinocytes undergo cytoskeleton rearrangements compatible with their motile behaviour and develop protrusive adhesion contacts. Matrix metalloproteinases (MMP) expression is crucial for
Alternative splicing controls cell lineage-specific responses to endogenous innate immune triggers within the extracellular matrix Matrix Biol. (IF 8.572) Pub Date : 2020-06-27 Sean P. Giblin; Anja Schwenzer; Kim S Midwood
The identification of barely more than 20,000 human genes was amongst the most surprising outcomes of the human genome project. Alternative splicing provides an essential means of expanding the proteome, enabling a single gene to encode multiple, distinct isoforms by selective inclusion or exclusion of exons from mature mRNA. However, mis-regulation of this process is associated with most human diseases
Mechanisms of procollagen and HSP47 sorting during ER-to-Golgi trafficking. Matrix Biol. (IF 8.572) Pub Date : 2020-06-17 Shakib Omari,Elena Makareeva,Laura Gorrell,Michal Jarnik,Jennifer Lippincott-Schwartz,Sergey Leikin
Efficient quality control and export of procollagen from the cell is crucial for extracellular matrix homeostasis, yet it is still incompletely understood. One of the debated questions is the role of a collagen-specific ER chaperone HSP47 in these processes. Most ER chaperones preferentially bind to unfolded polypeptide chains, enabling selective export of natively folded proteins from the ER after
Significance of host heparanase in promoting tumor growth and metastasis. Matrix Biol. (IF 8.572) Pub Date : 2020-06-11 Gan-Lin Zhang,Lilach Gutter-Kapon,Neta Ilan,Tahira Batool,Kailash Singh,Andreas Digre,Zhengkang Luo,Stellan Sandler,Yuval Shaked,Ralph D Sanderson,Xiao-Min Wang,Jin-Ping Li,Israel Vlodavsky
Heparanase, the sole heparan sulfate degrading endoglycosidase, regulates multiple biological activities that enhance tumor growth, angiogenesis and metastasis. Much of the impact of heparanase on tumor progression is related to its function in mediating tumor-host crosstalk, priming the tumor microenvironment to better support tumor growth and metastasis. We have utilized mice over-expressing (Hpa-tg)
Fibroblasts: The arbiters of extracellular matrix remodeling. Matrix Biol. (IF 8.572) Pub Date : 2020-06-03 Kristine Y DeLeon-Pennell,Thomas H Barker,Merry L Lindsey
Extracellular matrix (ECM) is the foundation on which all cells and organs converge to orchestrate normal physiological functions. In the setting of pathology, the ECM is modified to incorporate additional roles, with modifications including turnover of existing ECM and deposition of new ECM. The fibroblast is center stage is coordinating both normal tissue homeostasis and response to disease. Understanding
Reciprocal integrin/integrin antagonism through kindlin-2 and Rho GTPases regulates cell cohesion and collective migration. Matrix Biol. (IF 8.572) Pub Date : 2020-05-23 Ivo van der Bijl,Kalim Nawaz,Ugne Kazlauskaite,Anne-Marieke van Stalborch,Simon Tol,Ana Jimenez Orgaz,Iman van den Bout,Nathalie R Reinhard,Arnoud Sonnenberg,Coert Margadant
Collective cell behaviour during embryogenesis and tissue repair requires the coordination of intercellular junctions, cytoskeleton-dependent shape changes controlled by Rho GTPases, and integrin-dependent cell-matrix adhesion. Many different integrins are simultaneously expressed during wound healing, embryonic development, and sprouting angiogenesis, suggesting that there is extensive integrin/integrin
Cancer associated fibroblast: Mediators of tumorigenesis. Matrix Biol. (IF 8.572) Pub Date : 2020-05-22 Jennifer Alexander,Edna Cukierman
It is well accepted that the tumor microenvironment plays a pivotal role in cancer onset, development, and progression. The majority of clinical interventions are designed to target either cancer or stroma cells. These emphases have been directed by one of two prevailing theories in the field, the Somatic Mutation Theory and the Tissue Organization Field Theory, which represent two seemingly opposing
Cardiac fibroblast activation during myocardial infarction wound healing: Fibroblast polarization after MI. Matrix Biol. (IF 8.572) Pub Date : 2020-05-21 Michael J Daseke,Mavis A A Tenkorang,Upendra Chalise,Shelby R Konfrst,Merry L Lindsey
Cardiac wound healing after myocardial infarction (MI) evolves from pro-inflammatory to anti-inflammatory to reparative responses, and the cardiac fibroblast is a central player during the entire transition. The fibroblast mirrors changes seen in the left ventricle infarct by undergoing a continuum of polarization phenotypes that follow pro-inflammatory, anti-inflammatory, and pro-scar producing profiles
Cardiac fibroblast diversity in health and disease. Matrix Biol. (IF 8.572) Pub Date : 2020-05-21 Hesham Soliman,Fabio M V Rossi
The cardiac stroma plays essential roles in health and following cardiac damage. The major player of the stroma with respect to extracellular matrix deposition, maintenance and remodeling is the poorly defined fibroblast. It has long been recognized that there is considerable variability to the fibroblast phenotype. With the advent of new, high throughput analytical methods our understanding and appreciation
The elephant in the lung: Integrating lineage-tracing, molecular markers, and single cell sequencing data to identify distinct fibroblast populations during lung development and regeneration. Matrix Biol. (IF 8.572) Pub Date : 2020-05-19 Matthew Riccetti,Jason J Gokey,Bruce Aronow,Anne-Karina T Perl
During lung development, the mesenchyme and epithelium are dependent on each other for instructive morphogenic cues that direct proliferation, cellular differentiation and organogenesis. Specification of epithelial and mesenchymal cell lineages occur in parallel, forming cellular subtypes that guide the formation of both transitional developmental structures and the permanent architecture of the adult
Fibroblast heterogeneity and its impact on extracellular matrix and immune landscape remodeling in cancer. Matrix Biol. (IF 8.572) Pub Date : 2020-05-19 Mitsuo Yamauchi,Don L Gibbons,Chenghang Zong,Jared J Fradette,Neus Bota-Rabassedas,Jonathan M Kurie
Tumor progression is marked by dense collagenous matrix accumulations that dynamically reorganize to accommodate a growing and invasive tumor mass. Cancer-associated fibroblasts (CAFs) play an essential role in matrix remodeling and influence other processes in the tumor microenvironment, including angiogenesis, immunosuppression, and invasion. These findings have spawned efforts to elucidate CAF functionality
Regulators of cardiac fibroblast cell state. Matrix Biol. (IF 8.572) Pub Date : 2020-05-13 Ross Bretherton,Darrian Bugg,Emily Olszewski,Jennifer Davis
Fibroblasts are the primary regulator of cardiac extracellular matrix (ECM). In response to disease stimuli cardiac fibroblasts undergo cell state transitions to a myofibroblast phenotype, which underlies the fibrotic response in the heart and other organs. Identifying regulators of fibroblast state transitions would inform which pathways could be therapeutically modulated to tactically control maladaptive
Spatial-omics: Novel approaches to probe cell heterogeneity and extracellular matrix biology. Matrix Biol. (IF 8.572) Pub Date : 2020-05-13 Grace C Bingham,Fred Lee,Alexandra Naba,Thomas H Barker
Complex intercellular interactions as well as biomolecular and biomechanical cues from the extracellular matrix (ECM) profoundly affect cellular functions. Traditional transcriptomic and proteomic approaches have provided insight into disease progression by identifying discrete cellular subpopulations or microenvironmental signatures characteristic of normal or pathological tissues, however these techniques
Targeting the renin-angiotensin-aldosterone system in fibrosis. Matrix Biol. (IF 8.572) Pub Date : 2020-05-15 Mohammad AlQudah,Taben M Hale,Michael P Czubryt
Fibrosis is characterized by excessive deposition of extracellular matrix components such as collagen in tissues or organs. Fibrosis can develop in the heart, kidneys, liver, skin or any other body organ in response to injury or maladaptive reparative processes, reducing overall function and leading eventually to organ failure. A variety of cellular and molecular signaling mechanisms are involved in
Progranulin/EphA2 axis: A novel oncogenic mechanism in bladder cancer. Matrix Biol. (IF 8.572) Pub Date : 2020-05-14 Simone Buraschi,Thomas Neill,Shi-Qiong Xu,Chiara Palladino,Antonino Belfiore,Renato V Iozzo,Andrea Morrione
The growth factor progranulin plays a critical role in bladder cancer by modulating tumor cell motility and invasion. Progranulin regulates remodeling of the actin cytoskeleton by interacting with drebrin, an actin binding protein that regulates tumor growth. We previously discovered that progranulin depletion inhibits epithelial-to-mesenchymal transition and markedly reduces in vivo tumor growth.
T-cell regulation of fibroblasts and cardiac fibrosis. Matrix Biol. (IF 8.572) Pub Date : 2020-05-11 Amy D Bradshaw,Kristine Y DeLeon-Pennell
Inflammation contributes to the development of heart failure (HF) through multiple mechanisms including regulating extracellular matrix (ECM) degradation and deposition. Interactions between cells in the myocardium orchestrates the magnitude and duration of inflammatory cell recruitment and ECM remodeling events associated with HF. More recently, studies have shown T-cells have signficant roles in
Multi-scale models of lung fibrosis. Matrix Biol. (IF 8.572) Pub Date : 2020-05-11 Julie Leonard-Duke,Stephanie Evans,Riley T Hannan,Thomas H Barker,Jason H T Bates,Catherine A Bonham,Bethany B Moore,Denise E Kirschner,Shayn M Peirce
The architectural complexity of the lung is crucial to its ability to function as an organ of gas exchange; the branching tree structure of the airways transforms the tracheal cross-section of only a few square centimeters to a blood-gas barrier with a surface area of tens of square meters and a thickness on the order of a micron or less. Connective tissue comprised largely of collagen and elastic
Extracellular matrix-derived peptides in tissue remodeling and fibrosis. Matrix Biol. (IF 8.572) Pub Date : 2020-05-08 Lisandra E de Castro Brás,Nikolaos G Frangogiannis
Alterations in the composition of the extracellular matrix (ECM) critically regulate the cellular responses in tissue repair, remodeling, and fibrosis. After injury, proteolytic degradation of ECM generates bioactive ECM fragments, named matricryptins, exposing cryptic sites with actions distinct from the parent molecule. Matricryptins contribute to the regulation of inflammatory, reparative, and fibrogenic
Computational model predicts paracrine and intracellular drivers of fibroblast phenotype after myocardial infarction. Matrix Biol. (IF 8.572) Pub Date : 2020-03-21 Angela C Zeigler,Anders R Nelson,Anirudha S Chandrabhatla,Olga Brazhkina,Jeffrey W Holmes,Jeffrey J Saucerman
The fibroblast is a key mediator of wound healing in the heart and other organs, yet how it integrates multiple time-dependent paracrine signals to control extracellular matrix synthesis has been difficult to study in vivo. Here, we extended a computational model to simulate the dynamics of fibroblast signaling and fibrosis after myocardial infarction (MI) in response to time-dependent data for nine
Atrial Fibrillation and Cardiac Fibrosis: A Review on the Potential of Extracellular Matrix Proteins as Biomarkers. Matrix Biol. (IF 8.572) Pub Date : 2020-03-20 Alexander L Reese-Petersen,Morten S Olesen,Morten Karsdal,Jesper H Svendsen,Federica Genovese
The involvement of fibrosis as an underlying pathology in heart diseases is becoming increasingly clear. In recent years, fibrosis has been granted a causative role in heart diseases and is now emerging as a major contributor to Atrial Fibrillation (AF) pathogenesis. AF is the most common arrhythmia encountered in the clinic, but the substrate for AF is still being debated. Consensus in the field is
Chondrocytes respond to an altered heparan sulfate composition with distinct changes of heparan sulfate structure and increased levels of chondroitin sulfate. Matrix Biol. (IF 8.572) Pub Date : 2020-03-20 Velina Bachvarova,Tabea Dierker,Jeffrey Esko,Daniel Hoffmann,Lena Kjellen,Andrea Vortkamp
Heparan sulfate (HS) regulates the activity of many signaling molecules critical for the development of endochondral bones. Even so, mice with a genetically altered HS metabolism display a relatively mild skeletal phenotype compared to the defects observed in other tissues and organs pointing to a reduced HS dependency of growth-factor signaling in chondrocytes. To understand this difference, we have
Crtap and p3h1 knock out zebrafish support defective collagen chaperoning as the cause of their osteogenesis imperfecta phenotype. Matrix Biol. (IF 8.572) Pub Date : 2020-03-12 F Tonelli,S Cotti,L Leoni,R Besio,R Gioia,L Marchese,S Giorgetti,S Villani,C Gistelinck,R Wagener,B Kobbe,I A K Fiedler,D Larionova,B Busse,D Eyre,A Rossi,P E Witten,A Forlino
Prolyl 3-hydroxylation is a rare collagen type I post translational modification in fibrillar collagens. The primary 3Hyp substrate sites in type I collagen are targeted by an endoplasmic reticulum (ER) complex composed by cartilage associated protein (CRTAP), prolyl 3-hydroxylase 1 (P3H1) and prolyl cis/trans isomerase B, whose mutations cause recessive forms of osteogenesis imperfecta with impaired
Fibronectin has multifunctional roles in posterior capsular opacification (PCO). Matrix Biol. (IF 8.572) Pub Date : 2020-03-12 Mahbubul H Shihan,Mallika Kanwar,Yan Wang,Erin E Jackson,Adam P Faranda,Melinda K Duncan
Fibrotic posterior capsular opacification (PCO), one of the major complications of cataract surgery, occurs when lens epithelial cells (LCs) left behind post cataract surgery (PCS) undergo epithelial to mesenchymal transition, migrate into the optical axis and produce opaque scar tissue. LCs left behind PCS robustly produce fibronectin, although its roles in fibrotic PCO are not known. In order to
Basement membrane ligands initiate distinct signalling networks to direct cell shape Matrix Biol. (IF 8.572) Pub Date : 2020-03-06 Michael J. Randles; Franziska Lausecker; Jonathan D. Humphries; Adam Byron; Simon J. Clark; Jeffrey H. Miner; Roy Zent; Martin J. Humphries; Rachel Lennon
Cells have evolved mechanisms to sense the composition of their adhesive microenvironment. Although much is known about general mechanisms employed by adhesion receptors to relay signals between the extracellular environment and the cytoskeleton, the nuances of ligand-specific signalling remain undefined. Here, we investigated how glomerular podocytes, and four other basement membrane-associated cell
Corrigendum to "The heparan sulfate proteoglycan grip on hyperlipidemia and atherosclerosis" [Matrix Biol. 71-72 (2018) 262-282]. Matrix Biol. (IF 8.572) Pub Date : 2020-03-03 Philip L S M Gordts,Jeffrey D Esko
Substitution of murine type I collagen A1 3-hydroxylation site alters matrix structure but does not recapitulate osteogenesis imperfecta bone dysplasia. Matrix Biol. (IF 8.572) Pub Date : 2020-02-26 Wayne A Cabral,Nadja Fratzl-Zelman,MaryAnn Weis,Joseph E Perosky,Adrienne Alimasa,Rachel Harris,Heeseog Kang,Elena Makareeva,Aileen M Barnes,Paul Roschger,Sergey Leikin,Klaus Klaushofer,Antonella Forlino,Peter S Backlund,David R Eyre,Kenneth M Kozloff,Joan C Marini
Null mutations in CRTAP or P3H1, encoding cartilage-associated protein and prolyl 3-hydroxylase 1, cause the severe bone dysplasias, types VII and VIII osteogenesis imperfecta. Lack of either protein prevents formation of the ER prolyl 3-hydroxylation complex, which catalyzes 3Hyp modification of types I and II collagen and also acts as a collagen chaperone. To clarify the role of the A1 3Hyp substrate
Autophagic degradation of HAS2 in endothelial cells: A novel mechanism to regulate angiogenesis. Matrix Biol. (IF 8.572) Pub Date : 2020-02-19 Carolyn G Chen,Maria A Gubbiotti,Aastha Kapoor,Xiaorui Han,Yanglei Yu,Robert J Linhardt,Renato V Iozzo
Hyaluronan plays a key role in regulating inflammation and tumor angiogenesis. Of the three transmembrane hyaluronan synthases, HAS2 is the main pro-angiogenic enzyme responsible for excessive hyaluronan production. We discovered that HAS2 was degraded in vascular endothelial cells via autophagy evoked by nutrient deprivation, mTOR inhibition, or pro-autophagic proteoglycan fragments endorepellin and
The synthesis and secretion of versican isoform V3 by mammalian cells: A role for N-linked glycosylation. Matrix Biol. (IF 8.572) Pub Date : 2020-01-27 Ingrid A Harten,Gernot Kaber,Kiran J Agarwal,Inkyung Kang,Sean Reyes Ibarrientos,Gail Workman,Christina K Chan,Mary P Nivison,Nadine Nagy,Kathleen R Braun,Michael G Kinsella,Mervyn J Merrilees,Thomas N Wight
Versican is a large extracellular matrix (ECM) chondroitin sulfate (CS) proteoglycan found in most soft tissues, which is encoded by the VCAN gene. At least four major isoforms (V0, V1, V2, and V3) are generated via alternative splicing. The isoforms of versican are expressed and accumulate in various tissues during development and disease, where they contribute to ECM structure, cell growth and migration
PGC1α suppresses kidney cancer progression by inhibiting collagen-induced SNAIL expression. Matrix Biol. (IF 8.572) Pub Date : 2020-01-23 Hyeyoung Nam,Anirban Kundu,Garrett J Brinkley,Darshan S Chandrashekar,Richard L Kirkman,Balabhadrapatruni V S K Chakravarthi,Rachael M Orlandella,Lyse A Norian,Guru Sonpavde,Pooja Ghatalia,Fei Fei,Shi Wei,Sooryanarayana Varambally,Sunil Sudarshan
The transcriptional events that promote invasive and metastatic phenotypes in renal cell carcinoma (RCC) remain poorly understood. Here we report that the decreased expression of peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PGC1α) and the increased expression of several genes encoding collagen family members are associated with RCC tumor progression. PGC1α restoration attenuates
Tendon response to matrix unloading is determined by the patho-physiological niche. Matrix Biol. (IF 8.572) Pub Date : 2020-01-07 Stefania L Wunderli,Ulrich Blache,Agnese Beretta Piccoli,Barbara Niederöst,Claude N Holenstein,Fabian S Passini,Unai Silván,Louise Bundgaard,Ulrich Auf dem Keller,Jess G Snedeker
Although the molecular mechanisms behind tendon disease remain obscure, aberrant stromal matrix turnover and tissue hypervascularity are known hallmarks of advanced tendinopathy. We harness a tendon explant model to unwind complex cross-talk between the stromal and vascular tissue compartments. We identify the hypervascular tendon niche as a state-switch that gates degenerative matrix remodeling within
Single cell RNA-sequencing reveals cellular heterogeneity and trajectories of lineage specification during murine embryonic limb development. Matrix Biol. (IF 8.572) Pub Date : 2019-12-24 Natalie H Kelly,Nguyen P T Huynh,Farshid Guilak
The coordinated spatial and temporal regulation of gene expression in the murine hindlimb determines the identity of mesenchymal progenitors and the development of diversity of musculoskeletal tissues they form. Hindlimb development has historically been studied with lineage tracing of individual genes selected a priori, or at the bulk tissue level, which does not allow for the determination of single
Hypomorphic zebrafish models mimic the musculoskeletal phenotype of β4GalT7-deficient Ehlers-Danlos syndrome. Matrix Biol. (IF 8.572) Pub Date : 2019-12-17 Sarah Delbaere,Tim Van Damme,Delfien Syx,Sofie Symoens,Paul Coucke,Andy Willaert,Fransiska Malfait
β4GalT7 is a transmembrane Golgi enzyme, encoded by B4GALT7, that plays a pivotal role in the proteoglycan linker region formation during proteoglycan biosynthesis. Defects in this enzyme give rise to a rare autosomal recessive form of Ehlers-Danlos syndrome (EDS), currently known as 'spondylodysplastic EDS (spEDS-B4GALT7)'. This EDS subtype is mainly characterized by short stature, hypotonia and skeletal
Loss of LRP1 promotes acquisition of contractile-myofibroblast phenotype and release of active TGF-β1 from ECM stores. Matrix Biol. (IF 8.572) Pub Date : 2019-12-11 Jennifer Schnieder,Argen Mamazhakypov,Anna Birnhuber,Jochen Wilhelm,Grazyna Kwapiszewska,Clemens Ruppert,Philipp Markart,Lukasz Wujak,Karla Rubio,Guillermo Barreto,Liliana Schaefer,Malgorzata Wygrecka
In healing tissue, fibroblasts differentiate to α-smooth muscle actin (SMA)-expressing contractile-myofibroblasts, which pull the wound edges together ensuring proper tissue repair. Uncontrolled expansion of the myofibroblast population may, however, lead to excessive tissue scarring and finally to organ dysfunction. Here, we demonstrate that the loss of low-density lipoprotein receptor-related protein
Heparanase promotes myeloma stemness and in vivo tumorigenesis. Matrix Biol. (IF 8.572) Pub Date : 2019-12-05 Kaushlendra Tripathi,Vishnu C Ramani,Shyam K Bandari,Rada Amin,Elizabeth E Brown,Joseph P Ritchie,Mark D Stewart,Ralph D Sanderson
Heparanase is known to enhance the progression of many cancer types and is associated with poor patient prognosis. We recently reported that after patients with multiple myeloma were treated with high dose chemotherapy, the tumor cells that emerged upon relapse expressed a much higher level of heparanase than was present prior to therapy. Because tumor cells having stemness properties are thought to
The role of extracellular matrix in biomechanics and its impact on bioengineering of cells and 3D tissues. Matrix Biol. (IF 8.572) Pub Date : 2019-12-02 Max Urbanczyk,Shannon L Layland,Katja Schenke-Layland
The cells and tissues of the human body are constantly exposed to exogenous and endogenous forces that are referred to as biomechanical cues. They guide and impact cellular processes and cell fate decisions on the nano-, micro- and macro-scale, and are therefore critical for normal tissue development and maintaining tissue homeostasis. Alterations in the extracellular matrix composition of a tissue
Scavenger Receptor Cysteine-Rich domains of Lysyl Oxidase-Like2 regulate endothelial ECM and angiogenesis through non-catalytic scaffolding mechanisms. Matrix Biol. (IF 8.572) Pub Date : 2019-11-20 Claudia Umana-Diaz,Cathy Pichol-Thievend,Marion F Marchand,Yoann Atlas,Romain Salza,Marilyne Malbouyres,Alain Barret,Jérémie Teillon,Corinne Ardidie-Robouant,Florence Ruggiero,Catherine Monnot,Philippe Girard,Christophe Guilluy,Sylvie Ricard-Blum,Stéphane Germain,Laurent Muller
Lysyl oxidases are major actors of microenvironment and extracellular matrix (ECM) remodeling. These cross-linking enzymes are thus involved in many aspects of physiopathology, including tumor progression, fibrosis and cardiovascular diseases. We have already shown that Lysyl Oxidase-Like 2 (LOXL2) regulates collagen IV deposition by endothelial cells and angiogenesis. We here provide evidence that
Glypican-6 stimulates intestinal elongation by simultaneously regulating Hedgehog and non-canonical Wnt signaling. Matrix Biol. (IF 8.572) Pub Date : 2019-11-20 Wen Shi,Tomoyuki Kaneiwa,Marzena Cydzik,Jean Gariepy,Jorge Filmus
We report here that Glypican-6 (GPC6)-null mice display at birth small intestines that are 75% shorter than those of normal littermates. Notably, we demonstrate that the role of GPC6 in intestinal elongation is mediated by both Hedgehog (Hh) and non-canonical Wnt signaling. Based on results from in vitro experiments, we had previously proposed that GPC6 stimulates Hh signaling by interacting with Hh
Nuclear softening is essential for protease-independent migration. Matrix Biol. (IF 8.572) Pub Date : 2019-01-12 Alakesh Das,Amlan Barai,Melissa Monteiro,Sandeep Kumar,Shamik Sen
During amoeboidal migration, cancer cells migrate in a protease-independent manner by squeezing through pre-existing gaps in the extracellular matrix (ECM). However, the extent to which cells alter their physical properties in order to sustain this mode of migration remains unclear. Here, we address this question by documenting biophysical changes in the properties of highly invasive MDA-MB-231 and
Limb- and tendon-specific Adamtsl2 deletion identifies a role for ADAMTSL2 in tendon growth in a mouse model for geleophysic dysplasia. Matrix Biol. (IF 8.572) Pub Date : 2019-02-07 Dirk Hubmacher,Nandaraj Taye,Zerina Balic,Stetson Thacker,Sheila M Adams,David E Birk,Ronen Schweitzer,Suneel S Apte
Geleophysic dysplasia is a rare, frequently lethal condition characterized by severe short stature with progressive joint contractures, cardiac, pulmonary, and skin anomalies. Geleophysic dysplasia results from dominant fibrillin-1 (FBN1) or recessive ADAMTSL2 mutations, suggesting a functional link between ADAMTSL2 and fibrillin microfibrils. Mice lacking ADAMTSL2 die at birth, which has precluded
Denervation-induced skeletal muscle fibrosis is mediated by CTGF/CCN2 independently of TGF-β. Matrix Biol. (IF 8.572) Pub Date : 2019-02-01 Daniela L Rebolledo,David González,Jennifer Faundez-Contreras,Osvaldo Contreras,Carlos P Vio,Joanne E Murphy-Ullrich,Kenneth E Lipson,Enrique Brandan
Muscular fibrosis is caused by excessive accumulation of extracellular matrix (ECM) that replaces functional tissue, and it is a feature of several myopathies and neuropathies. Knowledge of the biology and regulation of pro-fibrotic factors is critical for the development of new therapeutic strategies. Upon unilateral sciatic nerve transection, we observed accumulation of ECM proteins such as collagen
Thrombospondin-2 regulates extracellular matrix production, LOX levels, and cross-linking via downregulation of miR-29. Matrix Biol. (IF 8.572) Pub Date : 2019-03-13 N E Calabro,A Barrett,A Chamorro-Jorganes,S Tam,N J Kristofik,Hao Xing,Ayomiposi M Loye,W C Sessa,K Hansen,T R Kyriakides
Collagen fibrillogenesis and crosslinking have long been implicated in extracellular matrix (ECM)-dependent processes such as fibrosis and scarring. However, the extent to which matricellular proteins influence ECM protein production and fibrillar collagen crosslinking has yet to be determined. Here we show that thrombospondin 2 (TSP2), an anti-angiogenic matricellular protein, is an important modulator
p16Ink4a deletion in cells of the intervertebral disc affects their matrix homeostasis and senescence associated secretory phenotype without altering onset of senescence. Matrix Biol. (IF 8.572) Pub Date : 2019-02-24 Emanuel J Novais,Brian O Diekman,Irving M Shapiro,Makarand V Risbud
Intervertebral disc degeneration is an important contributor to chronic low back and neck pain. Although many environmental and genetic factors are known to contribute to disc degeneration, age is still the most significant risk factor. Recent studies have shown that senescence may play a role in age-related disc degeneration and matrix catabolism in humans and mouse models. Clearance of p16Ink4a-positive
Citrullination of fibronectin alters integrin clustering and focal adhesion stability promoting stromal cell invasion. Matrix Biol. (IF 8.572) Pub Date : 2019-04-17 Victoria L Stefanelli,Shilpa Choudhury,Ping Hu,Yining Liu,Anja Schwenzer,Chiuan-Ren Yeh,Dwight M Chambers,Kelly Pesson,Wei Li,Tatiana Segura,Kim S Midwood,Matthew Torres,Thomas H Barker
The extracellular matrix (ECM) microenvironment is increasingly implicated in the instruction of pathologically relevant cell behaviors, from aberrant transdifferentation to invasion and beyond. Indeed, pathologic ECMs possess a panoply of alterations that provide deleterious instructions to resident cells. Here we demonstrate the precise manner in which the ECM protein fibronectin (FN) undergoes the
Tendon tissue microdamage and the limits of intrinsic repair. Matrix Biol. (IF 8.572) Pub Date : 2019-07-17 Tino Stauber,Ulrich Blache,Jess G Snedeker
The transmission of mechanical muscle force to bone for musculoskeletal stability and movement is one of the most important functions of tendon. The load-bearing tendon core is composed of highly aligned collagen-rich fascicles interspersed with stromal cells (tenocytes). Despite being built to bear very high mechanical stresses, supra-physiological/repetitive mechanical overloading leads to tendon
Fibroblast activation protein restrains adipogenic differentiation and regulates matrix-mediated mTOR signaling. Matrix Biol. (IF 8.572) Pub Date : 2019-07-17 Rachel Blomberg,Daniel P Beiting,Martin Wabitsch,Ellen Puré
Obesity is a risk factor for multiple diseases, including diabetes, cardiovascular disease, and cancer. Within obese adipose tissue, multiple factors contribute to creating a disease-promoting environment, including metabolic dysfunction, inflammation, and fibrosis. Recent evidence points to fibrotic responses, particularly extracellular matrix remodeling, in playing a highly functional role in the
Scaffold stiffness influences breast cancer cell invasion via EGFR-linked Mena upregulation and matrix remodeling. Matrix Biol. (IF 8.572) Pub Date : 2019-07-16 Anthony J Berger,Carine M Renner,Isaac Hale,Xinhai Yang,Suzanne M Ponik,Paul S Weisman,Kristyn S Masters,Pamela K Kreeger
Clinically, increased breast tumor stiffness is associated with metastasis and poorer outcomes. Yet, in vitro studies of tumor cells in 3D scaffolds have found decreased invasion in stiffer environments. To resolve this apparent contradiction, MDA-MB-231 breast tumor spheroids were embedded in 'low' (2 kPa) and 'high' (12 kPa) stiffness 3D hydrogels comprised of methacrylated gelatin/collagen I, a
Biallelic KRT5 mutations in autosomal recessive epidermolysis bullosa simplex, including a complete human keratin 5 "knock-out". Matrix Biol. (IF 8.572) Pub Date : 2019-07-11 Hassan Vahidnezhad,Leila Youssefian,Maryam Daneshpazhooh,Hamidreza Mahmoudi,Ariana Kariminejad,Judith Fischer,Julie Christiansen,Holm Schneider,Alyson Guy,Lu Liu,John A McGrath,Cristina Has,Jouni Uitto
Epidermolysis bullosa simplex (EBS) is usually inherited as an autosomal dominant disease due to monoallelic gain-of-function mutations in KRT5 or KRT14. Although autosomal recessive forms of EBS have been associated with mutations in at least 10 genes, recessive EBS due to homozygous biallelic KRT5 mutations has not been reported previously; it has been hypothesized that it would result in prenatal
Elastin architecture. Matrix Biol. (IF 8.572) Pub Date : 2019-07-10 Howard Vindin,Suzanne M Mithieux,Anthony S Weiss
Elastic fibers are an essential component of the extracellular matrix where they provide structural integrity and elastic recoil in a number of important tissues. A major constituent of these fibers is elastin, an insoluble metabolically stable polymer formed via extensive crosslinking of the monomeric precursor tropoelastin. Research over the past few decades has shown that tropoelastin possesses
The role of elastin-derived peptides in human physiology and diseases. Matrix Biol. (IF 8.572) Pub Date : 2019-07-08 Aurélie Le Page,Abdelouahed Khalil,Patrick Vermette,Eric H Frost,Anis Larbi,Jacek M Witkowski,Tamas Fulop
Once considered as inert, the extracellular matrix recently revealed to be biologically active. Elastin is one of the most important components of the extracellular matrix. Many vital organs including arteries, lungs and skin contain high amounts of elastin to assure their correct function. Physiologically, the organism contains a determined quantity of elastin from the early development which may
Peptide gels of fully-defined composition and mechanics for probing cell-cell and cell-matrix interactions in vitro. Matrix Biol. (IF 8.572) Pub Date : 2019-07-08 J C Ashworth,J L Thompson,J R James,C E Slater,S Pijuan-Galitó,K Lis-Slimak,R J Holley,K A Meade,A Thompson,K P Arkill,M Tassieri,A J Wright,G Farnie,C L R Merry
Current materials used for in vitro 3D cell culture are often limited by their poor similarity to human tissue, batch-to-batch variability and complexity of composition and manufacture. Here, we present a "blank slate" culture environment based on a self-assembling peptide gel free from matrix motifs. The gel can be customised by incorporating matrix components selected to match the target tissue,
Trends in the design and use of elastin-like recombinamers as biomaterials. Matrix Biol. (IF 8.572) Pub Date : 2019-07-06 Arturo Ibáñez-Fonseca,Tatjana Flora,Sergio Acosta,José Carlos Rodríguez-Cabello
Elastin-like recombinamers (ELRs), which derive from one of the repetitive domains found in natural elastin, have been intensively studied in the last few years from several points of view. In this mini review, we discuss all the recent works related to the investigation of ELRs, starting with those that define these polypeptides as model intrinsically disordered proteins or regions (IDPs or IDRs)
Tenascin-C increases lung metastasis by impacting blood vessel invasions. Matrix Biol. (IF 8.572) Pub Date : 2019-07-06 Zhen Sun,Inés Velázquez-Quesada,Devadarssen Murdamoothoo,Constance Ahowesso,Alev Yilmaz,Caroline Spenlé,Gerlinde Averous,William Erne,Felicitas Oberndorfer,Andre Oszwald,Renate Kain,Catherine Bourdon,Pierre Mangin,Claire Deligne,Kim Midwood,Chérine Abou-Faycal,Olivier Lefebvre,Annick Klein,Michael van der Heyden,Marie-Pierre Chenard,Gerhard Christofori,Carole Mathelin,Thomas Loustau,Thomas Hussenet
Metastasis is a major cause of death in cancer patients. The extracellular matrix molecule tenascin-C is a known promoter of metastasis, however the underlying mechanisms are not well understood. To further analyze the impact of tenascin-C on cancer progression we generated MMTV-NeuNT mice that develop spontaneous mammary tumors, on a tenascin-C knockout background. We also developed a syngeneic orthotopic
Sequence variants of human tropoelastin affecting assembly, structural characteristics and functional properties of polymeric elastin in health and disease. Matrix Biol. (IF 8.572) Pub Date : 2019-06-26 Sean E Reichheld,Lisa D Muiznieks,Robert Lu,Simon Sharpe,Fred W Keeley
Elastin is the polymeric protein responsible for the physiologically important properties of extensibility and elastic recoil of cardiovascular, pulmonary and many other tissues. In spite of significant advances in the understanding how monomeric tropoelastin is assembled into the polymeric elastic matrix, details of this assembly process are still lacking. In particular it is not clear how the various
Non-invasive marker-independent high content analysis of a microphysiological human pancreas-on-a-chip model. Matrix Biol. (IF 8.572) Pub Date : 2019-06-22 Aline Zbinden,Julia Marzi,Katharina Schlünder,Christopher Probst,Max Urbanczyk,Scott Black,Eva M Brauchle,Shannon L Layland,Udo Kraushaar,Garry Duffy,Katja Schenke-Layland,Peter Loskill
The increasing prevalence of diabetes, its heterogeneity, and the limited number of treatment options drive the need for physiologically relevant assay platforms with human genetic background that have the potential to improve mechanistic understanding and e\xpedite diabetes-related research and treatment. In this study, we developed an endocrine pancreas-on-a-chip model based on a tailored microfluidic
Elastic fibers and elastin receptor complex: Neuraminidase-1 takes the center stage. Matrix Biol. (IF 8.572) Pub Date : 2019-06-18 Amar Bennasroune,Béatrice Romier-Crouzet,Sébastien Blaise,Muriel Laffargue,Roman G Efremov,Laurent Martiny,Pascal Maurice,Laurent Duca
Extracellular matrix (ECM) has for a long time being considered as a simple architectural support for cells. It is now clear that ECM presents a fundamental influence on cells driving their phenotype and fate. This complex network is highly specialized and the different classes of macromolecules that comprise the ECM determine its biological functions. For instance, collagens are responsible for the
The role of fibrillin and microfibril binding proteins in elastin and elastic fibre assembly. Matrix Biol. (IF 8.572) Pub Date : 2019-06-18 Alan R F Godwin,Mukti Singh,Michael P Lockhart-Cairns,Yasmene F Alanazi,Stuart A Cain,Clair Baldock
Fibrillin is a large evolutionarily ancient extracellular glycoprotein that assembles to form beaded microfibrils which are essential components of most extracellular matrices. Fibrillin microfibrils have specific biomechanical properties to endow animal tissues with limited elasticity, a fundamental feature of the durable function of large blood vessels, skin and lungs. They also form a template for
Collagen XIII-derived ectodomain regulates bone angiogenesis and intracortical remodeling. Matrix Biol. (IF 8.572) Pub Date : 2019-06-17 Jarkko Koivunen,Antti V Kemppainen,Mikko A Finnilä,Riikka Keski-Filppula,Heli Härönen,Hongmin Tu,Henri Pellikka,Anne Heikkinen,Elina Kylmäoja,Raija Sormunen,Ilkka Miinalainen,Simo Saarakkala,Valerio Izzi,Taina Pihlajaniemi
Osteoporosis is the most common degenerative bone disease that occurs when the balance of bone production and resorption is perturbed. Loss of bone mass or alteration in its quality leads to significant weakening of the bones and subsequently to higher fracture risk. Collagen XIII (ColXIII) is a conserved transmembrane protein expressed in many mesenchymal tissues. Here we show that ColXIII is a regulator
Tension in fibrils suppresses their enzymatic degradation - A molecular mechanism for 'use it or lose it'. Matrix Biol. (IF 8.572) Pub Date : 2019-06-12 Karanvir Saini,Sangkyun Cho,Lawrence J Dooling,Dennis E Discher
Tissue homeostasis depends on a balance of synthesis and degradation of constituent proteins, with turnover of a given protein potentially regulated by its use. Extracellular matrix (ECM) is predominantly composed of fibrillar collagens that exhibit tension-sensitive degradation, which we review here at different levels of hierarchy. Past experiments and recent proteomics measurements together suggest
Transcriptomic analysis reveals that BMP4 sensitizes glioblastoma tumor-initiating cells to mechanical cues. Matrix Biol. (IF 8.572) Pub Date : 2019-06-09 Jasmine H Hughes,Jeanette M Ewy,Joseph Chen,Sophie Y Wong,Kevin M Tharp,Andreas Stahl,Sanjay Kumar
The poor prognosis of glioblastoma (GBM) is associated with a highly invasive stem-like subpopulation of tumor-initiating cells (TICs), which drive recurrence and contribute to intra-tumoral heterogeneity through differentiation. These TICs are better able to escape extracellular matrix-imposed mechanical restrictions on invasion than their more differentiated progeny, and sensitization of TICs to
Covalent cross-linking of basement membrane-like matrices physically restricts invasive protrusions in breast cancer cells. Matrix Biol. (IF 8.572) Pub Date : 2019-06-01 Katrina M Wisdom,Dhiraj Indana,Pei-En Chou,Rajiv Desai,Taeyoon Kim,Ovijit Chaudhuri


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Media problems considered
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Design entrepreneur Ian Reid discusses why your business needs a website what what it should cost to get it done.
Facebook wants to boost your business
"We realised that there was an ecosystem that makes use of Facebook and Instagram, and it's easier to build in an environment like that."
What every T&T business should know about technology
Above: Business analysis. Photo by avemario/Depositphotos. This interview with Mark Lyndersay was conducted by Newsday's Kalifa Clyne and published as "Digital 101" in the September 2018 […]
Digicel announces LTE network completion
Above: Jabbor Kayumov with DigicelTT's Ookla Speedtest award at today's Business Update meeting with the media. Photos by Mark Lyndersay. Digicel today announced that it had […]
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Auster 5, G-AMVD / 1565, Maurice Hammond
This picture is © FTP Aviation Photos and may not be used or published without permission.
Registration: G-AMVD
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Model Auster 5
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Escape to the heart of the countryside and enjoy the views from this pretty stone barn, enjoy your morning coffee with the visiting wildlife. Take in the grounds with a walk around the lakes.
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Murky Vista
by Rick Wall - Scattered satire with a chance of humor - posted MWF
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Chopped Liver - 🍽
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How did chopped liver get such a bad name? I mean, everybody disdains chopped liver. Even other deli dishes feel superior to chopped liver. Pickled herring -
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And a pickled herring said, "So what am I, chopped liver?"
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COVID-19 Coronavirus Updates and Guidance
The County is taking a number of actions to keep residents safe and minimize the spread of COVID-19. Find status information for County operations and services.
Precinct 1 - Wilkens
Precinct 1 - Wilkens
Read news updates from Precinct 1 - Wilkens.
Keyword: attempted robbery
Posted by:
At 2:20 a.m., the unknown suspect, implying a weapon, entered the Holiday Inn and went behind the counter. The suspect demanded money but was told there was no cash. The suspect left empty handed.
Posted by:
At 8:34 p.m., the unknown suspect, armed with a knife approached the victim but stole nothing. The victim was not injured.
Keywords: 21227, 2700 block of arbutus avenue, attempted robbery, precinct 1
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At 10:30 p.m., two unknown suspects approached the victim as he was leaving Wells Fargo. One suspect displayed a gun and the other a knife. When the suspects demanded the victim's cellphone, he ran to the High's Store and nothing was taken.
Keywords: 1000 block of maiden choice lane, 21227, attempted robbery, precinct 1
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Revised September 28, 2016


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Research Policies
- Funding Opportunities Announcement Guidance
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This workflow shows how medical assistants can provide a check to ensure that evidence-based care is delivered by identifying patients with heart disease who, according to protocol, should have, but have not, been prescribed aspirin.
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Part of an AHRQ curriculum used to train practice facilitators, this resource explains the fundamentals of building and working with quality improvement (QI) teams in primary care practices.
This Word worksheet helps primary care practices create action plans for implementing evidence. It has practices identify improvements they want to make; set measurable, realistic (i.e., SMART) goals; and list testable changes to achieve them.
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This resource provides an example of how a practice can translate evidence on treatment for hypertension (high blood pressure) into a protocol for the primary care team, highlighting the responsibilities medical assistants can take on.
This learning guide explains how to improve electronic health record (EHR) data quality to stimulate practice quality improvement.
This implementation guide by the Safety Net Medical Home Initiative addresses why care teams are important for improving patient care and ways to build an effective care team that meets patients' needs and expectations.


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If you would like to add your own testimony, email us through the contact page HERE
From: Bekki & Rob Holmes
(Mon 13th Jan 2014 at 15:14)
Our daughter attended Bagworth preschool from 2009-2012 and our son has been going there since 2012. Over the last 5 years, we have been constantly pleased with how both our children progressed and how happy they were/are there. Their kindness and love of working with children shows in all that they do with them. Both of our children thoroughly enjoyed bagworth preschool and have blossomed whist being there.
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Bagworth Pre-school is a wonderful place for your children to go to, the staff are the best. They are kind, caring, the children are nurtured and nothing is too much trouble. All of my 3 children have attended from the tender age of 2years old and couldnt have wished for a better start in life. they have supported me and my family through some difficult times and went above and beyond their duties. Tracey, Marlene, Rita, Louise and Kay you are truely wonderful!
Kate and Jed Deathridge (July 2014)
Thabkyou so much for looking after Jed for the past 18 months, looking over his learning journey it is lovely to see how much he has grown and changed. Thank you for playing such a positive role in that. Your friendly family atmosphere has been really enjoyed by Jed, Rory and me. Thankyou x
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Our son spent his pre-school years here before moving on to primary school & our daughter is a full time attender to this "Outstanding Ofstead" pre-school. This is a truly wonderful pre-school where our son & daughter love every minute being a part of the activities provided. The level of supervision is outstanding and the staff are all second to none. Do take time to see what they offer for your childs early years learning. In our view, Bagworth pre-school is more than just a pre-school; and place where our little ones have nothing but happy memories and love for the people they have met there.
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Ukah Enjoins Mathematical Association Of Teachers To Enhance Their Teaching Methods
By Magnus Emuji
Delta State Commissioner for Basic and Secondary Education, Chief Patrick Ukah, has enjoined teachers and stakeholders of Mathematics in the state to show more commitment and devise measures to arouse the interest of students in the subject.
Chief Ukah gave the advice in Asaba when the Mathematical Association of Nigeria, Delta State Chapter, led by its Chairman, Dr. C. E Emeronye, paid him a courtesy visit.
He said that the association should strive to remove the phobia of students towards Mathematics and urged them to always organise training programmes for teachers of the subject in order for them to be effectively abreast with modern trends in the subject.
Chief Ukah particularly called on the association to focus more on the foundational stage such as primaries one to three and students who were preparing for external examinations.
The Basic and Secondary Education Commissioner recalled that the last 1000 teachers employed by the Okowa-led administration were largely on areas of the subject needs of the public secondary schools in the state.
Earlier, Dr. Emeronye who informed the commissioner that the visit was to introduce the new executives of the body to him and to intimate him with the activities of the association, said that the association was planning a workshop to train teachers of mathematics in the state.
Dr. Emeronye noted that the content of the training would dwell on modem ways of solving mathematics, adding that a similar programme would be organised for students with a view to encouraging them to develop interest in Mathematics and eradicate their fear of the subject.
He solicited the support of the ministry, saying that the association would continue to improve mathematics in the state.
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