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- TaichungPermanent
The Plant Manager will oversee all daily operations of the plant from production and manufacturing to ensuring policies and procedures are followed. They develop processes that will maximize stewardship, safety, quality and productivity.
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Top Taiwanese brand JV with global MNC project
Rich funds and proactive expansion of manpower
- TaichungPermanent
Leading supply company from the U.S. is looking for a sourcing talent to join.
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American Fortune 500 industrial supply company
Good career progression
- Hsinchu CityPermanent
As an OSAT Planning Manager, you will be an individual contributor to monitor OSAT for forecast, material, inventory, production schedule and delivery.
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New Position Due to Company Expansion and Business Growth
Partner With Global Tier 1 Customers to Provide The Best Products
- TaichungPermanent
You will be in charge of the production planning and the relationship with suppliers
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Work-life balance
Creative and driven environment
- Hsinchu CityPermanent
Our Client, a world leading semiconductor manufacturer is looking for a professional and skillful Procurement Manager with over 10 years experience in equipment sourcing and with solid leadership experience.
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World Leading Semiconductor Manufacturer Expanding Its Organization
Looking For a Professional and Skillful Procurement Leader To Join
- TaichungPermanent
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Nike Core Dri-FIT Open Hem Adult Baseball Pants
- Whether you are in the field or at the plate, the Nike Men's Core Dri-FIT Open Hem Baseball Pant is great for your next big game. Made of 100% polyester warp knit, the pant features Dri-FIT fabric technology that wicks moisture away from the body to help keep you dry and cool. The brass zipper and 2 metal snap closures ensure a great fit, and the reinforced knees offer durability. 2 back welt pockets.
- Made of 100% polyester warp knit with Dri-FIT fabric technology that wicks away moisture to help keep you dry and cool
- 2 back welt pockets
- 2 metal snap closures with a brass zipper
- Standard fit with open hems for comfortable wear
Browse all deals at Modell's Sporting Goods
See more in Baseball & Baseball Accessories
See more from Nike
* This offer may contain time-sensitive information and offers. Please check with Modell's Sporting Goods to confirm actual price & availability.
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Modell's Sporting Goods
29 Route 9 South
Englishtown, NJ 07726
Modell's Sporting Goods
1900 Route 70 East
Lakewood, NJ 08701
Modell's Sporting Goods
180 State Route 35s Space 1204
Eatontown, NJ 07724
Modell's Sporting Goods
1 Route 37 West
Toms River, NJ 08755
Modell's Sporting Goods
2130 Highway 35 South
Holmdel, NJ 07733
Modell's Sporting Goods
2501 Route 130s
Riverton, NJ 08077
Modell's Sporting Goods
200 Route 73 North
West Berlin, NJ 08091
Modell's Sporting Goods
2000 Route 38
Cherry Hill, NJ 08034

subset: commoncrawl


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Next Round of Stimulus Checks May Include Another $1200 Payment to Eligible Adults
We'll have to see what the Senate says…
We all know that the first round of stimulus checks consisted of $1,200 per adult who earned under $75,000 in 2019, with an additional $500 per child.
But what might a second round look like?
Here's the scoop, Yahoo Money:
Trending: City Unanimously Rejects US Flag Mural In Front of State House, But Pushes Through BLM Artwork
The House on Friday passed another coronavirus relief package, dubbed the HEROES Act, sending it to the Republican-dominated Senate where it's expected to face stiff opposition. The new legislation is worth $3 trillion and would provide up to $1,200 per individual with a maximum amount of $6,000 per household.
Similar to the first stimulus payments, single adults with income up to $75,000 will get the full $1,200 payment. Married couples with income up to $150,000 will get $2,400. Single parents who file as head of household with income up to $112,500 will get the full $1,200 check.
Reduced checks will be available for those who earn above those income thresholds. The payment would be reduced by 5% for every 5% increase in income above $75,000 for individuals and $150,000 for married couples. Eligibility will be based on a taxpayer's adjusted gross income from their latest tax return.
Read more about it at this link.
Here's @playbookplus's assessment of Pelosi's bill.
This is what House Democrats are spending their time and energy on: pic.twitter.com/8suxZKpCm2
— Mark Bednar (@MarkBednar) May 15, 2020
The bill gives a tax cut to upper income blue state real estate owners for 2020 and 2021. pic.twitter.com/8dODlIRFZB
— Matt Stoller (@matthewstoller) May 12, 2020
Black Lives Matter Rioter to Cop: 'I Hope Someone Kills Your Whole F— Family!' (Video)
Highly disturbing…
Do some people wake up and say, "ya know, I'm gonna do everything in my power to put another person down simply because I hate my country and want to see everything change dramatically!" Antifa radicals probably do. What happened in Portland the other day is a complete disgrace. And it won't receive an iota of coverage from the mainstream media. WATCH: https://twitter.com/livesmattershow/status/1282258068999245825?ref_src=twsrc%5Etfw%7Ctwcamp%5Etweetembed%7Ctwterm%5E1282258068999245825%7Ctwgr%5E&ref_url=https%3A%2F%2Fwww.weaselzippers.us%2F452201-portland-rioter-to-police-i-hope-someone-kills-your-whole-fuking-family%2F The recent COVID-19 spike in many states around the nation, including Arizona, California, Florida, and New York, is likely due to Black Lives Matter protests. Thousands upon thousands of politically ignorant lefties decided to stand shoulder-to-shoulder and blame every single police officer living today for the death of George Floyd. And now, Americans are paying the price — again. According to people like Bill de Blasio, the protests were called for. Religious gatherings, however, not so much. WATCH: https://twitter.com/dcexaminer/status/1278334684418551812?ref_src=twsrc%5Etfw%7Ctwcamp%5Etweetembed%7Ctwterm%5E1278334684418551812%7Ctwgr%5E&ref_url=https%3A%2F%2Fwww.thegatewaypundit.com%2F2020%2F07%2Fnyc-mayor-de-blasio-defends-ban-religious-gatherings-says-black-lives-matter-protests-ok-profound-meaning-video%2F
AOC Says Crime Spike In New York May Be Due to People Being 'Scared to Pay Their Rent'
There are comedians and then there's AOC. She's a whole different kind of funny and she doesn't even realize it. Facepalm. From The Daily Wire: Rep. Alexandria Ocasio-Cortez (D-NY) claimed on Sunday that the surge in crime in New York City is happening because people are "scared to pay their rent" and because of high unemployment numbers due to the pandemic. Ocasio-Cortez made the remarks and other misleading statements during a Zoom video call that was posted to Twitter by The Hill. WATCH: https://twitter.com/thehill/status/1282358303549464578?ref_src=twsrc%5Etfw%7Ctwcamp%5Etweetembed%7Ctwterm%5E1282358303549464578%7Ctwgr%5E&ref_url=https%3A%2F%2Fwww.dailywire.com%2Fnews%2Focasio-cortez-nyc-crime-surge-maybe-due-to-people-being-scared-to-pay-their-rent-dont-have-jobs Protests around the nation are largely dominated by white liberals. They believe they are helping the black community combat racism by agreeing with the radical wing that law enforcement should be defunded. It literally makes zero sense. From The Daily Wire: On Thursday, Ami Horowitz released a new video to YouTube in which he asks white and black New Yorkers if they "support abolishing the police." Their answers are…quite different. […] When asked about the relationship between the NYPD and members of the community, a man wearing a blue Nike hat claims that "it's pretty good," noting that "all police officers are not bad," and that there are ones who "really care about the people and really want to help the people." VIDEO: https://www.youtube.com/watch?v=Jv5-mc4U_Zw&feature=emb_title
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Black Lives Matter Rioter to Cop: 'I Hope Someone Kills Your Whole F— Family!' (Video)
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Based on 28 reviews.
Gearbox Repairs, Volkswagen EosAll good. Collected and returned same day after service of DSG.
Engine Management Light, Kia RioGreat customer service from QCD, very quick to sort the problem which turned out to be a duff spark plug.
Car Won't Start - Mobile, Vauxhall VectraRecovered car quickly, car was completely dead. Got to work on it next day found faults and repaired. Friendly and helpful. Great service will definitely be using again.
Mobile Mechanic, Vauxhall InsigniaI was initially worried about the extent of the cars issues as I'm not a mechanic, and being a key worker needing the car all week I was crapping myself, QCD were not only quick at identifying the issue, they were super communicative which put me very much at ease. I had further work done while they had the car, MOT, new pads all round, 2 new tyres, clutch replacement, They were very honest as my car has a very expensive DMF they assessed it and told me I wouldn't need a new one just yet, when I do I absolutely know where I'm going. 10/10 can't fault the service at all, I was very well looked after. Thank you guys so very much


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Adult Acne Causes And 5 Proven Home Remedies That Treat Pimples
The number of people suffering from adult acne has been increasing for the past two decades. Although pimple outbreaks usually occur during teenage years, they could still emerge during the adult years. It is even more difficult to treat pimples at an older age. Here are the most common adult acne causes and four proven home remedies that treat pimples the natural way.
Common Causes
Hormonal imbalance is the most common cause of adult acne. Before females enter the menstrual cycle, their hormones fluctuate, as per Dr. Julia Tzu of Wall Street Dermatology. Dr. Rebecca Kazin of the Washington Institute of Dermatologic Laser Surgery and Johns Hopkins Department of Dermatology also noted that fluctuation of male androgens like testosterone results in chin, neck and back pimples, reported Self.
High levels of stress also trigger hormonal changes. The adrenal gland produces more of the cortisol hormone that testosterone leaks out to the body when triggered by stress. For women, more oil is produced during this state that then causes the pimple breakouts.
Another cause of adult acne is air pollution. When you come in contact with dirt, facial oils and dirt tend to block your pores and eventually lead to an acne breakout.
Here are five natural remedies that can prevent these causes from developing into unwanted pimple breakouts:
Oatmeal and Honey Paste
According to Live Strong, oatmeal is acts as an absorbent while honey has antiseptic and toning properties. When combined, the oatmeal absorbs the excess oil from the skin while the honey prevents bacteria buildup.
Tea Tree Oil
Tea tree oil is also an antifungal ingredient that shields you from skin infections. It prevents adult acne which is caused by certain infections. You can maximize its antiseptic function by applying the solution directly to the affected area. Leave it on overnight and rinse by the morning.
Crushed Peppermint
Peppermint is also a natural anti-inflammatory ingredient that treats adult acne. If you are already suffering from a pimple breakout, apply a peppermint paste by crushing three leaves and rubbing them directly on the affected area. Leave it on for 10 minutes before rinsing it off with cold water.
Apple Cider Vinegar
Adult acne worsens when your skin's pH levels are acidic. Vinegar flushes excess oil on the skin and normalizes its pH. Apple cider vinegar also has antibacterial properties that prevent further infection and swelling. Drench a cotton ball with apple cider vinegar and apply to the affected area. Boiling water and letting it steam near your facial skin also maximizes the benefits of this remedy.
Oil-Free Products
Keeping your face clean with proper hygiene also does the trick. Since pimple breakouts occur and worsen when your skin is exposed to dirt, washing it with oil-free and organic products extracts the pimple-causing agents and keeps your skin's oil levels normal.


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American Weddings Blog
All articles containing the tag:
All articles containing the tag:
Become a Wedding Officiant with Our Free Online Ordination!
Published: Friday, Sep. 6th, 2019
Big news, Ministers: we're officially launching our Wedding Wall, a place where you can publish and share wedding ceremonies to inspire other ministers and couples!...
Published: Wednesday, Dec. 12th, 2018
We hear all of the time that one of the main reasons couples ask their friend or family member to perform their wedding ceremony is because they want the ceremony to be personal. And many couples figure that no one can make their ceremony more personal than a good friend or a close family member who knows their story best....
Become a Wedding Officiant with Our Free Online Ordination!


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Article content
Most Canadians have just enough knowledge about mould to foster a nagging sense that it's dangerous, yet not enough knowledge to understand that there's no need to fear it if you're prepared.
Why mould grows
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House Works: How to fight mould and win Back to video
Mould thrives whenever warmth, moisture and a food source come together. That's because mould spores are everywhere, even on surfaces that appear synthetic and food-free. Bathrooms are always a perennial source of mould because of the ample water, warmth and soap residue there, and windows are a particularly common Canadian mould breeding ground, too.
If your windows formed running condensation this past winter — and many did for the first time because of lower-than-usual temperatures — you probably have mould on the edges of your windows right now.
Walls can also form patches of mould during winter in areas where couches and drapes are pushed against exterior walls. Take a look at your place and see if mould grew this past winter.


text: Pay attention to the tempo at which you lift weights. Studies have shown that using a tempo that emphasizes the eccentric contraction of an exercise (such as 4 seconds down, 2 second hold, 1 second up) can increase post-exercise metabolic rate for 72 hours, compared to 15 hours for a 1/1/1 tempo. Increased metabolic rate= lower body fat. If your goal is explosive power, however, a 1/1/1 or 1/0/1 tempo is the way to go. So put some strategy behind your speed the next time you pick up that weight!


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Within EU Project TRIPOD, new ways of saving energy are being studied to improve ship operational costs. The main objective of the TRIPOD project is the development and validation of a new propulsion concept for improved energy efficiency of ships which is based on the combination of three existing propulsion technologies. In particular TRIPOD explores the feasibility of integrating podded propulsors and tip loaded endplate propellers into energy recovery systems based on counter rotating propeller (CRP) principle. A non-rotatable pod unit called Rudderpod is installed behind the ship main propeller. CRP units consisting of different combinations of CLT and conventional propellers are being analyzed in ballast and load conditions for a retrofit and a new building scenario. CFD tools and model tests are combined to facilitate the design process. A method for the extrapolation of model tests to full scale and another for the accurate estimation of effective wakes by CFD tools have been developed. TRIPOD includes the realization of an economical cost benefit analysis for the operation of a reference ship
|Original language
|Title of host publication
|Proceedings of the Third International Symposium on Marine Propulsors - smp13 5 - 8 May 2013, Launceston, Tasmania, Australia
|Publication status
|Published - 2013
|MoE publication type
|A4 Article in a conference publication
|3rd International Symposium on Marine Propulsors, SMP'13 - Launceston, Australia
Duration: 5 May 2013 → 8 May 2013
|3rd International Symposium on Marine Propulsors, SMP'13
|5/05/13 → 8/05/13
- Contrarotating propeller (CRP)
- CLT propeller
- Pod propulsion
- model test
- Tip Loaded
- economic analysis
- saving energy
Fingerprint Dive into the research topics of 'Combination of Pod, CLT and CRP Propulsion for Improving Ship Efficiency: The TRIPOD project'. Together they form a unique fingerprint.
Cite this
Sánchez-Caja, A., Pérez-Sobrino, M., Quereda, R., Nijland, M., Veikonheimo, T., González-Adalid, J., Saisto, I., & Auriarte, A. (2013). Combination of Pod, CLT and CRP Propulsion for Improving Ship Efficiency: The TRIPOD project. In Proceedings of the Third International Symposium on Marine Propulsors - smp13 5 - 8 May 2013, Launceston, Tasmania, Australia (pp. 347-357). [8A.2] http://www.marinepropulsors.com/proceedings/2013/8A.2.pdf


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- Medicine Applications
- Personal Statement
- Interviews
- Math/Science
- Summer School
- Blog
The Situational Judgement section of the University Clinical Aptitude Test (UCAT) uses scenarios to test your ability to understand real world situations and assess appropriate behaviour when making decisions. The concepts that are presented by these sorts of questions may seem a bit alien at this point, for example, involving discussions on due diligence or patient confidentiality. However, with practice and appropriate preparation during year 12, you'll soon feel more and more comfortable with making the right decisions, just like professional doctors and dentists.
This is probably very different from anything you have done before, however, Situational Judgement is a commonly used test format within medicine and dentistry. All medical students have to sit a situational judgement test (or SJT) at the end of medical school and some medical specialities also use these as part of the selection process for their post-graduate training. The scenarios are all based on real-life situations that doctors and medical students may face (e.g. an ethical dilemma), so when preparing for this section of the UCAT exam, I would recommend that you pay attention because this could help you out in the real world too!
In this blog post, I will cover:
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The University Clinical Aptitude Test (UCAT) is a widely recognised exam used by medical schools, as a tool to assess candidates applying to study medicine.
We at theMSAG recognise that the application process can be extremely stressful, so we have collected all the information you are going to need to complete your registration for the UCAT, should you be planning to sit the exam in time for the 2020/21 medicine application cycle.
We have compiled a list of all important UCAS test dates in 2019 that candidates taking the UCAT should be aware of, so have a read below and make sure you mark them in your calendar!


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Marriage certificates search background state people
It was also filed with a different county agency. Note: In many United States counties, the terms license , certificate and return are often used interchangeably as names for an official document proving that a marriage has occurred.
- Navigation menu.
- free people finder with social security.
- davie county north carolina tax records.
In King County, they represent distinct records. King County Archives E.
Fir St. Seattle, WA Monday, Tuesday, Thursday, and Friday: 9 am-4 pm. Please note the Archives is closed Wednesdays.
Marriage License Department of the Circuit Court for Howard County
King County Marriage Records, present. Order King County marriage records online. If you can't locate your certificate or if you prefer to pay by cash or check, please go through our standard request form. Vital records offices keep documents for roughly 80 to years. Older records may be kept at the state archives , and are generally available with fewer restrictions.
King County Marriage Records, 1853-present
Very old records, like from the 17 th and 18 th centuries, may be at a local historical society. The National Archives in Washington D. The Social Security Death Index also known as the Death Master File is a government database that includes the name, birthdate, date of death and Social Security number of most Americans who have died since It is often used by genealogists, who can purchase information through commercial sites like Ancestry. The entire database is available from the National Technical Information Service for an annual fee.
The new process was described in a Deseret News article of April 18, , " Filing Marriage Certificates ," which references the new "marriage law. Contents include: full names including a woman's maiden name, social security numbers, current address es , date and place of birth, names of respective parents including maiden name of mother, birthplaces of respective parents, and race or nationality of each party.
Upon successful application, a license is issued and shall be returned within 30 days with the marriage date, location, and names of two or more witnesses.
The county clerk files the license and certificate of marriage either in a book or, more recently, in electronic form. A copy or transcript is also sent to the State Registrar for the compilation of statistics and, for marriages and divorces after , an available certified abstract.
Death | Florida Department of Health
Series listed below without a link to an inventory may only be accessed at county offices. Marriage Records. Woods said in his Message to the Legislature Series : There is no statute law in Utah upon the subject of marriage.
spearmanlaw.com/wp-content/recuperar/1597-reinstalling-ms-office.php I do no hesitate to say that in my judgment there ought to be. Marriage may be a sacrament. It is is none the less a civil contract.


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Annual financial statements and tax returns
Tax consultancy
Before becoming a certified accountant, Christian Möller worked as a sales clerk. Christian Möller, formerly a qualified office clerk and vocational instructor, has been a certified accountant for our company since 2013. He is responsible for balance sheets, tax returns and office management. He also operates in the field of corporate liquidation and non-profit law.


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Anthony "Tony" Paul Tomasi, 79, passed away on Saturday, June 20, 2020 at his home in St. Charles, IL with his family by his side. He was born on January 21, 1941 to Sylvester and Antoinette (nee Chiaro) Tomasi in Chicago, IL. Anthony married his sweetheart Carol Karabin on September 2, 1962 at St. Salomea Catholic Church in Chicago.
Anthony served his country in the United States Navy. Then he worked as an air traffic controller for 33 years at the Chicago Air Route Traffic Control Center in Aurora, IL. At his St. Charles home of 43 years, Anthony and Carol raised their four children, welcomed new generations of grandchildren, and cared for numerous animals. With his horse Vandy, Anthony served as a member of the Kane County Sheriff's Mounted Patrol. Anthony also loved racing cars with his sons at Blackhawk Farms Raceway and Road America.
Anthony leaves behind his loving wife of 57 years, Carol, of St. Charles, IL and their four children: Tony (Regina) Tomasi of New Port Richey, FL; Michelle (Michael) Willman of St. Charles, IL; Reno (Rachel) Tomasi of Marengo, IL; and Brian (Carolyn) Tomasi of Elgin, IL. He also leaves behind nine grandchildren: Kevin (Maureen), Naomi (Tyler), Molly, Tony, Mitchell, Amanda, Jackson, Nicholas, and Lucy; three great-grandchildren: Xander, Michael, and Leo; his mother Antoinette; his sister Juliana Felts; and two nieces and a nephew: Sondra, Sherry, and Leslie.
He was preceded in death by his father Sylvester and granddaughter Ashley (Michael) DeLaney.
All services will be private. In lieu of flowers, memorial donations may be made to Tails Humane Society, 2250 Barber Greene Road, DeKalb, IL 60115.
Arrangements entrusted to Moss Family Funeral Home – St. Charles 630-584-2000 or www.mossfuneral.com


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Depending upon the mix needed, the bins automatically dispense the correct amount of the required aggregate. The dry material is routed to a pugmill mixer located at the bottom of the tower. Here the liquid asphalt is added. After thorough mixing, the bottom of the mixer opens and the batch is dispensed into a truck or conveyed to a storage silo.
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SINOSUN Group is a leader in manufacture and distribution of Construction Machinery in China.Business Line:Stationary asphalt mixing plant,Mobile asphalt mixing plant,Continuous asphalt mixing plant,Asphalt plant component,Ancillary asphalt equipment Our brand is recognized worldwide for high quality, reliability and excellent after-sales services.
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Reduce, reuse, recycle: Mixing technology | Article | KHL
Benninghoven's transportable asphalt mixing plant is now available with a recycling drum using counterflow action with hot-gas generator. The TBA transportable asphalt mixing plant covers the performance ranges 160–320 tonnes per hour, and is suitable for semi-mobile and stationary use.
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The median home value in Sunfield, MI is $139,000. This is lower than the county median home value of $145,900. The national median home value is $231,815. The average price of homes sold in Sunfield, MI is $139,000. Approximately 73% of Sunfield homes are owned, compared to 18% rented, while 9% are vacant. Sunfield real estate listings include condos, townhomes, and single family homes for sale. Commercial properties are also available. If you like to see a property, contact Sunfield real estate agent to arrange a tour today! Learn more about Sunfield Real Estate.
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Country living at its finest with this 4 bed 3 bath home on 1.92 acres! Remodeled to the studs with elegant high-end finishes. As you enter through the French doors, take in the vast open space: living, dining and kitchen spans over 700sqft! Bright white kitchen, soft close cabinetry, granite countertops, tiled backsplash. Plus, 25x24 great room will thrill with a ''wall of window'' hill-top view and toasty pellet stove. Main floor master suite boasts soaking tub and walk in shower! Two more bedrooms on main level. Classy spiral staircase leads you up to open 340sqft bedroom with space for sitting area, game area, many options! Pergo flooring, can lighting, energy efficient windows throughout the home, new furnace! Enjoy the outdoors on a large patio with ''sun sails'' & above ground pool
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Category Archives: Immortality Medicine
Researchers Link Aging to Cellular Interactions That Occur Across Generations
Posted: April 25, 2014 at 1:41 pm
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Newswise CHAPEL HILL, N.C. The evidence for what causes aging has typically been limited to the study of a single organisms lifespan; our cells divide many times throughout our lives and eventually cause organs and our bodies to age and break down. But new research from the UNC School of Medicine suggests that how we age might depend on cellular interactions that we inherit from ancestors throughout many generations.
By studying the reproductive cells of nematodes tiny worms found in soil and compost bins Shawn Ahmed, PhD, an associate professor of genetics, identified the Piwi/piRNA genome silencing pathway, the loss of which results in infertility after many generations. He also found a signaling pathway a series of molecular interactions inside cells that he could tweak to overcome infertility while also causing the worms to live longer adult lives.
The research, in collaboration with researchers at the University of Cambridge and described in a paper published in the journal Cell Reports, suggests that its possible to manipulate the aging process of progeny before theyre even born.
The finding gives scientists a deeper understanding of what may govern aging and age-related diseases, such as some cancers and neurodegenerative conditions.
Typically, nematodes produce about 30 generations in a matter of months and remain fertile indefinitely. Ahmed and colleagues found that a mutation in the Piwi/piRNA cellular pathway of germ cells gradually decreased the worms ability to reproduce as the mutation was passed down through the generations and eventually caused complete sterility. But when Ahmeds team manipulated a different protein DAF-16/FOXO the nematodes overcame the loss of the Piwi pathway. The worms did not become sterile; generations of worms reproduced indefinitely, achieving a sort of generational immortality. Moreover, it has been well established that DAF-16/FOXO plays a role in nematodes living longer.
Achieving longer life suggests that theres an effect on the aging of somatic cells the cells that make up the body and organs of an organism.
Thats the really interesting thing about this, said Ahmed, a member of the UNC Lineberger Comprehensive Cancer Center. What weve found implies that theres some sort of relationship between somatic cell aging and this germ line immortality process weve been studying.
What that relationship is, precisely, remains unknown. But so does the exact mechanism by which human somatic cells age as they divide throughout our lives. That is, exactly how we age at the cellular level is still not entirely understood.
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Researchers Link Aging to Cellular Interactions That Occur Across Generations
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UNC researchers link aging to cellular interactions that occur across generations
Posted: at 1:41 pm
Contact: Mark Derewicz firstname.lastname@example.com 919-923-0959 University of North Carolina Health Care
April 24, 2014
CHAPEL HILL, N.C. The evidence for what causes aging has typically been limited to the study of a single organism's lifespan; our cells divide many times throughout our lives and eventually cause organs and our bodies to age and break down. But new research from the UNC School of Medicine suggests that how we age might depend on cellular interactions that we inherit from ancestors throughout many generations.
By studying the reproductive cells of nematodes tiny worms found in soil and compost bins Shawn Ahmed, PhD, an associate professor of genetics, identified the Piwi/piRNA genome silencing pathway, the loss of which results in infertility after many generations. He also found a signaling pathway a series of molecular interactions inside cells that he could tweak to overcome infertility while also causing the worms to live longer adult lives.
The research, in collaboration with researchers at the University of Cambridge and described in a paper published in the journal Cell Reports, suggests that it's possible to manipulate the aging process of progeny before they're even born.
The finding gives scientists a deeper understanding of what may govern aging and age-related diseases, such as some cancers and neurodegenerative conditions.
Typically, nematodes produce about 30 generations in a matter of months and remain fertile indefinitely. Ahmed and colleagues found that a mutation in the Piwi/piRNA cellular pathway of germ cells gradually decreased the worms' ability to reproduce as the mutation was passed down through the generations and eventually caused complete sterility. But when Ahmed's team manipulated a different protein DAF-16/FOXO the nematodes overcame the loss of the Piwi pathway. The worms did not become sterile; generations of worms reproduced indefinitely, achieving a sort of generational immortality. Moreover, it has been well established that DAF-16/FOXO plays a role in nematodes living longer.
Achieving longer life suggests that there's an effect on the aging of somatic cells the cells that make up the body and organs of an organism.
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UNC researchers link aging to cellular interactions that occur across generations
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Celldex's Phase 1 study of CDX-1401 published in Science Translational Medicine
Posted: April 17, 2014 at 3:41 pm
Contact: Sarah Cavanaugh email@example.com 508-864-8337 Celldex Therapeutics
HAMPTON, NJ (April 16, 2014): Celldex Therapeutics, Inc. (NASDAQ: CLDX) announced today that final data from its Phase 1 study of CDX-1401 in solid tumors, including long-term patient follow-up, have been published in Science Translational Medicine (Vol 6 Issue 232). The data demonstrate robust antibody and T cell responses and evidence of clinical benefit in patients with very advanced cancers and suggest that CDX-1401 may predispose patients to better outcomes on subsequent therapy with checkpoint inhibitors. CDX-1401 is an off-the-shelf vaccine consisting of a fully human monoclonal antibody with specificity for the dendritic cell receptor DEC-205 linked to the NY-ESO-1 tumor antigen. The vaccine is designed to activate the patient's immune system against cancers that express the tumor marker NY-ESO-1. While the function of NY-ESO-1 continues to be explored, references in the literature suggest that its expression might reflect the acquisition of properties that cancers find useful, such as immortality, self-renewal, migratory ability and the capacity to invade.
The Phase 1 study of CDX-1401 is the first clinical study to demonstrate that an off-the-shelf vaccine that targets dendritic cells in vivo through DEC-205 can safely lead to robust humoral and cellular immunityovercoming a significant challenge in the development of protein based vaccines. Targeting protein antigens to the DEC-205 receptor on dendritic cells was pioneered by the late Ralph Steinman, MD, a member of Celldex's Scientific Advisory Board. Dr. Steinman received the 2011 Nobel Prize in Physiology or Medicine for his discovery of the dendritic cell and its role in adaptive immunity. This now-proven ability to target proteins, like NY-ESO-1, to dendritic cells to generate potent immune responses specific to these proteins represents a promising approach for the next generation of vaccines against pathogens and cancer.
"CDX-1401 offers a novel, well-tolerated and practical approach to generating protein specific immunity that can be readily combined with other treatment strategies to boost immunity against pathogens and tumors," said Dr. Madhav Dhodapkar, MBBS, Arthur H. and Isabel Bunker Professor of Medicine and Immunobiology, Chief of the Section of Hematology at the Department of Internal Medicine and Clinical Research Program Leader of the Hematology Program at Yale Cancer Center and lead author of the paper. "The preliminary findings in patients who received therapy with a checkpoint inhibitor following the vaccine provide further rationale for combination immunotherapy strategies, meriting further investigation."
Thomas Davis, MD, Senior Vice President and Chief Medical Officer of Celldex Therapeutics added, "CDX-1401 has overcome a significant historical challenge in the development of protein based vaccines by successfully targeting dendritic cells in vivo. It now sits at the forefront of a new generation of off-the-shelf dendritic cell targeted vaccines that we believe hold significant promise. Based on the results observed in this Phase 1 study, we expect CDX-1401 to enter at least two combination studies this year with both our own investigational therapies and external therapies in melanoma and other indications where we believe a dendritic cell vaccine regimen could play an important role." Initial results from the Phase 1 study of CDX-1401 were presented at the 2012 Society for Immunotherapy Annual Meeting. The manuscript published today expands upon this data and includes longer-term patient follow up.
CDX-1401 Phase 1 Study Overview and Results
The study was designed to assess the safety, immunogenicity and clinical activity of escalating doses of CDX-1401 with TLR agonists (resiquimod and/or Poly ICLC (HiltonolTM) in 45 patients with advanced malignancies refractory to all available therapies. CDX-1401 was well tolerated, with no dose limiting or grade 3 toxicities reported. The most frequently reported adverse events were administration site reaction, fatigue, nausea and chills. Treatment induced humoral and cellular immunity to NY-ESO-1 in patients with NY-ESO-1 expressing tumors across various dose levels and adjuvant combinations.
Significant anti-NY-ESO-1 titers occurred in 79% (33/42) of evaluable patients, with high titers (>1:10,000) in 52% and very high titers (>1:100,000) in 33% of patients. Similarly strong humoral immunity developed in each cohort and in patients with or without confirmed NY-ESO-1 expression in their tumor. Approximately 54% of patients with NY-ESO-1 positive tumors had anti-NY-ESO-1 titers at baseline and most increased after vaccination. NY-ESO-1-specific T cell responses were absent or low at baseline, but increased post-vaccination in 56% of evaluable patients, including both CD4 and/or CD8 T cell responses. Durability of the T cell response was demonstrated in two patients from whom samples from additional cycles of CDX-1401 treatment were available. In these patients, the induction of NY-ESO-1 specific T cells was maintained through three cycles (approximately seven months) of treatment.
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Celldex's Phase 1 study of CDX-1401 published in Science Translational Medicine
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Doctors Can Now Grow Engineered Vaginas in Women
Posted: April 11, 2014 at 6:41 am
After decades of work, a team of doctors say they've successfully engineered vaginas that have been implanted and grown in women. The vaginas were grown in a lab from the female patients' own cells and later transferred to their bodies, where they formed into normal vaginas. The breakthrough bears some huge implications, too.
It sounds confusing at first, but the process was fairly simple. Anthony Atala from the Wake Forest School of Medicine led the research using a technique developed in the 1990s. The patients were all women born without functioning vaginas due to a rare but severe condition known as Mayer-Rokitansky-Kster-Hauser Syndrome. While they all had vulvas, the external part of the female sex organs, they didn't have a vaginal cavity, meaning they couldn't menstruate or have sex. There were also, obviously, psychological effects.
Using a technique first developed on rabbitswhere, funnily enough, the first solid organ grown was a penisAtala's team took samples from the women's vulvas and grew them on a degradable scaffold made of collagen in a lab. Once they'd reached the right level of maturity, the doctors inserted the engineered vagina into a cavity they'd formed in the patients' abdomens. The scaffold was attached to the uterus and a stent was used to hold it in place for the first six weeks. After just six months, the vagina was fully developed. Depending on the patient, Atala waited between four and eight years before publishing his findings to ensure there were no complications. There weren't.
"After the operation they were able to function normally. They had normal levels of desire, arousal, satisfaction and orgasm," Atala told the press. When asked whether the women could give birth, he sounded optimistic. "They haven't tried," he said, "but they can ovulate, so there is no reason to suspect that they cannot."
While this specific procedure stands to improve the lives of many women, the implications of growing an organ inside a patients' body is huge. Gizmodo interviewed Atala a few years ago, and he spoke of a future where all body parts could be grown in a lab and transplanted into a patient. It makes you wonder, if this is what immortality looks like. "I don't know how long it will take, but I do foresee a future when organs will be available off-the-shelf, ready to 'plug in' and replace injured or diseased organs," Atala said at the time. With today's news, we're that much closer to this future. [The Lancet via New Scientist]
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Doctors Can Now Grow Engineered Vaginas in Women
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Grief-stricken memorialize loved ones on 'R.I.P. T-shirts'
Posted: at 6:41 am
MIAMI They come to put their dead relatives and friends on a T-shirt.
A young woman clutches a photo of her murdered 16-year-old brother. He grins at the camera, his right hand clutching a gun. Three young men line up to pay homage to one of their friends, a "street soldier," with his Facebook profile picture.
Here at Studio X, inside the U.S.A. Flea Market, miles away from South Beach in a gritty pocket of Liberty City, is where black Miami's killed are memorialized. Pictures of the deceased are stamped onto plaques and necklace charms, but a majority of customers come to put a picture on a T-shirt.
For the bereaved who robe themselves in these memorial shirts, the act is a public expression of their loss. It is a ritual they turn to in their time of grief. It is a testimony of a life prematurely taken by violence in neighborhoods where these killings don't always make the news cycle.
The Studio X booth, with its purpose emblazoned on a sign out front - "Home of the R.I.P. T-shirts" - is often the first stop before funeral arrangements. And long after the funeral is over, the grief-stricken return. They come on their lost loved one's birthday and on the anniversary of the killing for more T-shirts to proclaim their sadness. Here, love is a memorial worn close to the heart and out in the street.
Ayleen Lopez, the soft-spoken graphic designer on duty, gently directs customers to a menu of images beneath plexiglass to use as a background for the photo of their loved ones.
"People do it because it's their way of remembering someone they loved," she said. "Not everyone understands it. In Miami, in the 'hood, this is how you show this person means something to me."
Menu item CR-14 depicts a cross topped with a crown of thorns. CR-17 is a pair of hands clasped in prayer. G-13 is Miami's skyline bordered by what looks like two AK-47 assault rifles on top and, along the bottom, a row of bullets.
Studio X is one of the better-known memorial shirt-printing enterprises locally, but similar businesses dot strip malls and flea markets throughout South Florida. They are part of the urban background of inner cities across the country.
"It should be once in a blue moon, but every week it's another body," said Leonard Brown, who designed memorial shirts for 12 years at StudioX.
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Grief-stricken memorialize loved ones on 'R.I.P. T-shirts'
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Gene therapy successfully regenerates an old organ inside a living animal
Posted: April 10, 2014 at 3:47 am
In a landmark study sure to provoke interest, researchers from the University of Edinburgh have regenerated an aged organ in vivo, inside a living animal to its youthful state though noninvasive manipulation of genes. Its a breakthrough that not only brings hope for a wide variety of age-related ailments, but which fundamentally challenges our idea of what aging is. This study treats the natural impacts of of time like symptoms of a disease and by treating those symptoms it seems to have tracked the cells back to their pre-disease (youthful) state.
The organ in question is the thymus, a small immune node that sits near the heart. It produces T-cells, one of the bodys most important immune response units, but over the course of a lifetime the thymus shrinks and T-cell production slows. This is thought to be one big reason (one of many) that elderly people suffer decreased immune response relative to younger people. This study used1- and 2-year old mice, and saw the typical drop in both thymus size and T-cell production with age.
The thymus is one of the most important parts of the immune system, especially in younger people.
Prior research had already identified a protein called FOXN1 as likely linked to thymus degeneration; its expression levels in the thymus seem linked to that organs fate. The mice in this study were bred with a specific genetic sensitivity, however, so that when exposed to the drug tamoxifen they would begin producing fully youthful levels of FOXN1, regardless of their actual age. It should be pointed out that the fact that these were genetically engineered mice is more crucial to the experimental setup than the therapeutic one; without the need to control for variables, scientists could plausibly increase FOXN1 levels through less convoluted measures.
The results? Mutant mice treated with tamoxifen showed total or near-total regeneration of their youthful thymus, while control mice also given tamoxifen showed predictable thymus function for their age. This held true for both the size of the organ itself and the abundance of the T-cells it produces. The regeneration seems to arise from the fact that FOXN1 is a transcription factor that controls expression of several other genes, and that these genes activate stem cell-like action in some thymus cells. By restoring FOXN1 levels, the researchers seem to have convinced the thymus to de-age itself at least, in this one very specific way.[DOI:10.1242/dev.103614]
The researchers are quick to point out the possible benefits to elderly people, or those afflicted by immune diseases. Increasing the ability to fight infection could also revolutionize hospital medicine, helping vulnerable patients fight infection by overclocking the thymus to produce a boost of white blood cells. Restoring the immune response of sick and elderly people would be, without an ounce of hyperbole, one of the most important medical advances in all of human history.
A separate study found that improper FOXN1 function causes a wasting immune disease. Sad
But this study is a far cry from proof that such utility could actually exist. If nothing else, it stands as an uncomfortable challenge to our ideas about just what agingis. Has the thymus really been regenerated or is it simply bigger and more active than it used to be?We do have a few relatively non-arbitrary measures of cell age, in particular measurements of telomere decay. Telomeres are long stretches of inactive DNA that cap our chromosomes on either end, and which seem to fray and shorten as cells live and replicate. A functional regeneration such as this one, coupled with genetic implants to re-lengthen telomeres and undo other sources of aging damage, could be difficult to distinguish from literal reversal of the aging process. (Read:What is transhumanism, or, what does it mean to be human?)
Thats a long way out, however. In the extreme long term, patchwork replacement of organs and body parts is even prophesied to allow immortality, and this study shows that we might be able to supplement grown organs with regenerated ones. Theres no telling how many tissues might be usefully regenerated with such a simple molecular switch but theres also currently no telling if these regenerated thymuses will continue to function well, or if such manipulation could cause unintended side-effects.
A lot more research is needed before human applications could even be discussed, but its an enticing goal. Any tool that could maintain the bodys own immune system could end up saving both lives and healthcare costs immensely of course, as weve discussed previously though, there could be some massive problems if we all start living to 100 or more.
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Gene therapy successfully regenerates an old organ inside a living animal
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Why Freezing Yourself Is a Terrible Way to Achieve Immortality
Posted: April 2, 2014 at 8:41 am
What happens after we die? It's a question that has plagued the human mind since we first developed the concept of "death." The search for an answerand, more importantly, a means of circumventing its effectshas encited organized religion and served to shape one of the foundations of human culture.
We've built pyramids to house our dead in the afterlife, constructed terracotta armies to protect them, sacrificed the living in their honor, and even developed preservation techniques to ward off decompositionall in the effort to somehow defy the permanence of death and resurrect at least a part, however intangible, of the deceased person. Ignoring the mysticism and religious fervor of these practices, they represent little more than elaborate burial techniques, which stubbornly remain a part of modern society.
But unlike the miraculous rebirth of one's soul at the hands of Osiris, the practice of cryonics promises the rebirth of a younger, fitter, and not-dead youall through the miracle of future scientific progress.
Cryonics is the practice of preserving "legally dead" human bodies in extremely cold temperatures with hopes that future advances in medical science can revive their corpses and cure what ails themor, at least, extract their memories and consciousness.
The basic idea is that by rapidly cooling the body after the heart has stopped, but before the brain begins to die from hypoxia, the body is rapidly cooled to extinguish the metabolism and halt decomposition. However, unlike short-term suspended animation techniques that are currently being developed to aid in cardiac and neural surgery, traumatic injury, and similar life-threatening emergencies, cryonics freezes you for the long haul.
Not unlike Miracle Max's distinction between the stages of death in The Princess Bride, there is a very fine but very important distinction between "legally dead" and "brain dead" as it relates to cryonics. Cryonics cannot be performed on someone who is still aliveregardless of how ill, the cryonic process would kill them and that constitutes murder. Cryonic preservation practitioners therefore rely on the information-theoretic definition of death rather than the standard, legal definition.
The subject must be deemed "legally dead" by a medical professional, which denotes when the person's heart has stopped beating. Between the time that the heart stops and the brain suffers irreparable damage from oxygen starvation is when the cryonic preservation process must take place, so that the cellular brain function may someday be restarted.
There are a number of facilities in the United States that handle cryonic preservation, including the Cryonics Institute in Detroit, the American Cryogenics Society in Sunnyvale, California, and the Alcor Life Extension Foundation in Scottsdale, Arizona. Each charges a hefty annual membership fee as well as upwards of six figures to actually preserve your corpse, though you can save a significant sum by preserving only your head or just the brain itself.
Once you're declared legally dead, an emergency response team from one of these facilities first will stabilize the oxygen levels in your blood to maintain minimal brain function during your transport to the cryo facility, as well as pack your body in ice and administer the anticoagulant heparin into your bloodstream to keep your juices flowing.
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Why Freezing Yourself Is a Terrible Way to Achieve Immortality
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Wallace Baine, Baine Street: Why the silence on science?
Posted: March 24, 2014 at 12:42 am
Neil deGrasse Tyson is a rock star.
Or, maybe it's better to compare the country's most famous astrophysicist to a sports star, the kind who'll spend two hours after every game autographing anything thrust in his direction.
If you have anything more than a passing familiarity with the mass media, you will have noticed that, in the past couple of weeks, this cat has been everywhere: CNN, Colbert, NPR, The New Yorker, Reddit, Good Morning Bakersfield.
I called him up last week and asked if he could come over and tell me about dark energy while I was eating breakfast. I woke up to find him cooking scrambled eggs in my kitchen.
Not that Tyson "NdT" to his friends is doing all this media slogging just for giggles. He's the host of the new Fox iteration of the old show "Cosmos," and he's doing his rounds. By taking on "Cosmos" to explain, educate and entertain audiences with astrophysics, Tyson is making explicit what has been implicit for years: That he is the heir to the late Carl Sagan as America's most famous science "popularizer."
Yes, it's an odd term, awkward, a bit condescending. But it's an indication of how rarely scientists and mainstream audiences actually talk to each other that we haven't come up with a better term for what Tyson does.
So, why is Tyson reviving a documentary show from the 1980s? To me, that's not a very interesting question. The better question is: Why aren't there more like him?
We live in a culture that produces battalions of celebrities, platoons of movie stars, brigades of reality-TV narcissists, posturing hip-hoppers, barely dressed divas, snarky comics, political big-mouths and cable talking heads. That's what we do in America create and maintain fame.
Yet, when it comes to science the very stuff of human intellectual development and exploration Tyson stands pretty much alone on the mountain of celebrity.
How many famous scientists can you name other than Tyson and Sagan?
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Wallace Baine, Baine Street: Why the silence on science?
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REVIEW The Fifth Beatle: The Brian Epstein Story, By Vivek J. Tiwary And Brian C. Robinson
Posted: March 22, 2014 at 11:41 am
The Fifth Beatle: The Brian Epstein Story, a meticulously researched, masterfully written and gorgeously illustrated graphic novel by award-winning Broadway producer Vivek J. Tiwary and artist Andrew C. Robinson, was a labor of love. (Cover art by Andrew C. Robinson)
Somewhere, along the mad and transcendental road of rock and roll, the tale of one of its greatest architects, masters and casualties has been lost. Somewhere, between the gyrating hips and rebel snarl of Elvis and the shallow, uninspired gushiness of emo, music history has forgotten one of its first antiheroes. Somewhere, somehow, the man responsible for turning popular culture, music and several generations, worldwide, upside-downand influencing every band sincehas been left for dead and buried, destined for obscurity but for a growing legion of fans-turned-archeologists.
The Fifth Beatle: The Brian Epstein Story, by award-winning Broadway theater producer Vivek J. Tiwary (A Raisin in the Sun, American Idiot, The Addams Family) and artist Andrew C. Robinson, resurrects the seminal Beatles manager, breathing life, color, validity, and resounding beauty, into his short, intense, often-overlooked life and his contributions shaping and molding the four young lads from Liverpool. The Beatles immortality, as documented in this meticulously researched, masterfully written and gorgeously illustrated graphic novel, is Epsteins legacy, as are the boundless torrents of love, hope and optimism shared through their songs.
It was Epstein who shed their leather jackets for matching tailored suits. It was Epstein who got them a record contract. Epstein who landed them in America and on The Ed Sullivan Show. Epstein who invented their synchronized bow, comforted and cared for them, transported them from The Cavern Clubs basement to the center of the worlds stage.
Through The Fifth Beatle, we hear his thoughts, see his struggles, feel his jubilation and his painJewish and gay, yearning for acceptance and self-worth. Visionary, businessman, family man, son, friend, tortured soul, matadorwe see Epsteins genius, his passion, his struggles and his flaws.
This must-read work of arta labor of love for Tiwary, which took 20 years to realizeis a worthy tribute, historical account, comic, biography, love letter and song to a man who shaped and molded music, and life itself.
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Community HealthNet offers comprehensive healthcare for all
Posted: March 16, 2014 at 8:41 am
Community HealthNet Health Centers is committed to offering comprehensive healthcare to adults and children. CHN provides a range of acute, chronic and preventative care. In addition to traditional prenatal, pediatric and family medicine services, CHN offers routine check-ups, health and wellness assessments, immunizations, screenings and referral based personalized counseling to individuals of all ages. As a federally qualified health center it is their mission to provide quality and affordable medical services to all individuals in need of health care. CHN has five locations throughout Lake County: Gary (2), Merrillville, Hammond and the school-based clinic in Calumet High School. They employ a staff of licensed and professional physicians who are committed to the health and well-being of their patients.
Since opening its doors in 1998, CHN continues to expand the scope of services that we offer our patients. Partnering with state and local organizations CHN is able to offer more affordable access to preventative health services such as mammograms. These services are made possible through a partnership with the Indiana State Department of Health Breast Cervical Cancer Program (BCCP). Recently CHN opened doors to the first Centering Pregnancy Clinic in Lake County offering a program aimed to improve birth immortality rates and coach mothers through a successful pregnancy. Funded by the March of Dimes, the Centering Pregnancy Clinic is operated by an on-staff certified nurse mid-wife. Just recently CHN partnered with Geminus Corporation to conduct on-site Domestic Violence Prevention trainings helping its medical staff to identify child abuse.
In need of insurance? CHN's got you covered! How about dental services? CHN can brighten your smile. Community HealthNet is partnered with Covering Kids and Families Indiana, a grassroots statewide initiative aimed to enroll individuals, primarily youth in state provided medical plans. As a certified application and enrollment site CHN employs outreach specialists working to educate, enroll and meet the demands of the Affordable Care Act through Marketplace enrollments. At the main site in Gary, CHN is partnered with Kool Smiles to provide dental services to both youth and adults.
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Community HealthNet offers comprehensive healthcare for all
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text: Arkansas PBS > Programs > Exploring Arkansas > Season 14 > Exploring Arkansas October 2018 Exploring Arkansas October 2018 Housed in a new facility at Hampson Archeological Museum State Park in Wilson, are artifacts from the "Nodena Site" which was inhabited by late Mississippian period Native Americans. Black Bass Lake is a hidden gem down a dirt road within the city limits of Eureka Springs. The Tontitown Grape Festival celebrates the town's Italian heritage and is one of the oldest festivals in the state, beginning in 1898. Electric Island is a special oasis in the middle of Lake Hamilton in Hot Springs, which is why it's protected by The Nature Conservancy as a Nature Preserve.