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Computational improvement of small-molecule inhibitors of Bacillus anthracis protective antigen activation through isostere-based substitutions J. Biomol. Struct. Dyn. Pub Date : 2020-07-14 Sandra V. R. L. Silva; Pedro J. Silva
There has recently been interest in the development of small-molecule inhibitors of the oligomerization of Bacillus anthracis protective antigen for therapeutic use. Some of the proposed lead compounds have, however, unfavorable solubility in aqueous medium, which prevents their clinical use. In this computational work, we have designed several hundreds of derivatives with progressively higher hydro-solubility
The computational quantum mechanical study of sulfamide drug adsorption onto X12Y12 fullerene-like nanocages: detailed DFT and QTAIM investigations J. Biomol. Struct. Dyn. Pub Date : 2020-07-14 Rahman Padash; Milad Rabbani Esfahani; Ali Shokuhi Rad
In the current work, the adsorption of sulfamide drug onto the exterior surface of four fullerene-like nanocages, including Al12N12, Al12P12, B12N12, and B12P12, was studied by employing density functional theory (DFT) and the quantum theory of atom in the molecule (QTAIM) calculations. Our calculations revealed that the sulfamide drug connects to the Al, B, P, and N atoms of Al12N12, Al12P12, B12N12
Computational discovery of small drug-like compounds as potential inhibitors of SARS-CoV-2 main protease J. Biomol. Struct. Dyn. Pub Date : 2020-07-14 Alexander M. Andrianov; Yuri V. Kornoushenko; Anna D. Karpenko; Ivan P. Bosko; Alexander V. Tuzikov
Abstract A computational approach to in silico drug discovery was carried out to identify small drug-like compounds able to show structural and functional mimicry of the high affinity ligand X77, potent non-covalent inhibitor of SARS-COV-2 main protease (MPro). In doing so, the X77-mimetic candidates were predicted based on the crystal X77-MPro structure by a public web-oriented virtual screening platform
Unravelling the unfolding pathway of human Fas-activated serine/threonine kinase induced by urea J. Biomol. Struct. Dyn. Pub Date : 2020-07-14 Khalid A. Alamry; Saurabha Srivastava; Mohd Shahbaaz; Parvez Khan; Preeti Gupta; Sunayana Begum Syed; Naved Azum; Abdullah M. Asiri; Asimul Islam; Faizan Ahmad; Md. Imtaiyaz Hassan
Fas-activated serine/threonine kinase (FASTK) is a mitochondria-associated nuclear protein that inhibits Fas- and UV-induced apoptosis. This protein is generally activated during Fas-mediated apoptosis by phosphorylating a nuclear RNA-binding protein T-cell intracellular antigen-1 and thus considered as a modulator of apoptosis. In the present study, we have examined the equilibrium unfolding and conformational
A quantum chemical view of the interaction of RNA nucleobases and base pairs with the side chains of polar amino acids J. Biomol. Struct. Dyn. Pub Date : 2020-07-14 Ashita Ohri; Preethi P. Seelam; Purshotam Sharma
Hydrogen bonding between amino acids and nucleobases is important for RNA–protein recognition. As a first step toward understanding the physicochemical features of these contacts, the present work employs density functional theory calculations to critically analyze the intrinsic structures and strength of all theoretically possible model hydrogen-bonded complexes involving RNA nucleobase edges and
Identification of potential drugs against SARS-CoV-2 non-structural protein 1 (nsp1) J. Biomol. Struct. Dyn. Pub Date : 2020-07-13 Gabriela de Lima Menezes; Roosevelt Alves da Silva
Non-structural protein 1 (nsp1) is found in all Betacoronavirus genus, an important viral group that causes severe respiratory human diseases. This protein has significant role in pathogenesis and it is considered a probably major virulence factor. As it is absent in humans, it becomes an interesting target of study, especially when it comes to the rational search for drugs, since it increases the
Complete chemical shift assignment and molecular modeling studies of two chromene derivatives as potential leads for new anticancer drugs J. Biomol. Struct. Dyn. Pub Date : 2020-07-13 Priscila Ivo Rubim de Santana; Denise Cristian Ferreira Neto; Arlan da Silva Goncalves; Joyce Sobreiro Francisco Diz de Almeida; Tanos Celmar Costa França; José Daniel Figueroa-Villar
The compounds 7-chloro-9-(2-hydroxy-4,4-dimethyl-6-oxocyclohex-1-en-1-yl)-3,3-dimethyl-2,3,4,9-tetrahydro-1H-xanthen-1-one (5) and 5-[-7-chloro-2,4-dioxo-1H, 2H, 3H, 4H, 5H-chromeno[2,3-d]pyrimidin-5-yl)]-1,3-diazinane-2,4,6-trione (7), were synthesized from dimedone and barbituric acid and had their three-dimensional structures and precise chemical shifts assignments obtained by Nuclear Magnetic Resonance
Structural study of letrozole and metronidazole and formation of self-assembly with graphene and fullerene with the enhancement of physical, chemical and biological activities J. Biomol. Struct. Dyn. Pub Date : 2020-07-13 Aljawhara H. Almuqrin; Jamelah S. Al-Otaibi; Y. Sheena Mary; Y. Shyma Mary; Renjith Thomas
Letrozole and metronidazole are two commonly used drugs for the management of breast cancer and parasitic infections, respectively. This manuscript attempts to study their structure, geometry, search for stable conformers using relaxed potential energy scan, spectral properties, quantum mechanical properties like energy and reactivity descriptors, intra molecular electron transfer properties, non-linear
In silico docking of phytocompounds to identify potent inhibitors of signaling pathways involved in prostate cancer J. Biomol. Struct. Dyn. Pub Date : 2020-07-09 Bhavana Jonnalagadda; Sumathy Arockiasamy; Umashankar Vetrivel; Abhinand P. A.
Androgens and androgen receptors (AR) are the master regulators in the development of prostate cancer. Majority of the patients show positive response to surgical or medical castration, while many patients show disease relapse after the treatment. Genomic profiling has proven that the deregulated PI3K, Ras/Raf, MAPK and EGFR signaling pathways confer survival and invasion advantage to the cancer cells
On the potential role of exosomes in the COVID-19 reinfection/reactivation opportunity J. Biomol. Struct. Dyn. Pub Date : 2020-07-09 Fatma Elrashdy; Abdullah A. Aljaddawi; Elrashdy M. Redwan; Vladimir N. Uversky
Abstract We propose here that one of the potential mechanisms for the relapse of the COVID-19 infection could be a cellular transport pathway associated with the release of the SARS-CoV-2-loaded exosomes and other extracellular vesicles. It is possible that this "Trojan horse" strategy represents possible explanation for the re-appearance of the viral RNA in the recovered COVID-19 patients 7–14 day
Identification of bioactive molecule from Withania somnifera (Ashwagandha) as SARS-CoV-2 main protease inhibitor J. Biomol. Struct. Dyn. Pub Date : 2020-07-08 Manish Kumar Tripathi; Pushpendra Singh; Sujata Sharma; Tej P. Singh; A. S. Ethayathulla; Punit Kaur
SARS-CoV-2 is the causative agent of COVID-19 and has been declared as pandemic disease by World Health Organization. Lack of targeted therapeutics and vaccines for COVID-2019 have triggered the scientific community to develop new vaccines or drugs against this novel virus. Many synthetic compounds and antimalarial drugs are undergoing clinical trials. The traditional medical practitioners widely use
Exploration and evaluation of bioactive phytocompounds against BRCA proteins by in silico approach J. Biomol. Struct. Dyn. Pub Date : 2020-07-08 H. Prabhavathi; K. R. Dasegowda; K. H. Renukananda; K. Lingaraju; H. Raja Naika
The proteins encoded by the two major breast cancer genes (BRCA1 and BRCA2), ensure the stability of DNA and prevent uncontrolled cell growth; mutation of these genes is linked to the development of hereditary breast cancers. Exploration of human breast cancer inhibitors plays a vital role in the drug discovery process. In the current work, in silico studies were performed which involves a computational
Potential of NO donor furoxan as SARS-CoV-2 main protease (Mpro) inhibitors: in silico analysis J. Biomol. Struct. Dyn. Pub Date : 2020-07-08 Abdullah G. Al-Sehemi; Mehboobali Pannipara; Rishikesh S. Parulekar; Omkar Patil; Prafulla B. Choudhari; M. S. Bhatia; P. K. Zubaidha; Yasinalli Tamboli
The sharp spurt in positive cases of novel coronavirus-19 (SARS-CoV-2) worldwide has created a big threat to human. In view to expedite new drug leads for COVID-19, Main Proteases (Mpro) of novel Coronavirus (SARS‐CoV‐2) has emerged as a crucial target for this virus. Nitric oxide (NO) inhibits the replication cycle of SARS-CoV. Inhalation of nitric oxide is used in the treatment of severe acute respiratory
Computational insight into the selective allosteric inhibition for PTP1B versus TCPTP: a molecular modelling study J. Biomol. Struct. Dyn. Pub Date : 2020-07-08 Garcia-Marin Javier
All over the world, diabetes mellitus type 2 has spread as a problematic pandemic. Despite currently available treatments, approved drugs still show undesirable side effects and loss of efficacy or target symptoms instead of causes. Protein tyrosine phosphatase 1B (PTP1B), since its discovery, has emerged as a very promising target against this disease. Although the information regarding the enzyme
Natural-like products as potential SARS-CoV-2 Mpro inhibitors: in-silico drug discovery J. Biomol. Struct. Dyn. Pub Date : 2020-07-08 Mahmoud A. A. Ibrahim; Khlood A. A. Abdeljawaad; Alaa H. M. Abdelrahman; Mohamed-Elamir F. Hegazy
Abstract In December 2019, a COVID-19 epidemic was discovered in Wuhan, China, and since has disseminated around the world impacting human health for millions. Herein, in-silico drug discovery approaches have been utilized to identify potential natural products (NPs) as Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro) inhibitors. The MolPort database that contains over
Insight into the sequence-structure relationship of TLR cytoplasm's Toll/Interleukin-1 receptor domain towards understanding the conserved functionality of TLR 2 heterodimer in mammals J. Biomol. Struct. Dyn. Pub Date : 2020-07-08 Soumya Kanti Ghosh; Bhaskar Saha; Raja Banerjee
The signaling response of TLR2 to ligands has always been as a homodimer or in heterodimerization with TLR1/TLR6. The Toll/Interleukin-1 Receptor (TIR) domain of the TLR cytoplasmic region regulates the dimerization and interactions with adaptor molecules to build an active signaling complex. To understand the conservation of functionality of the TLR2-heterodimers between the distantly related species
In-silico analysis of Calcium Dependent Protein Kinase 6 of Cryptosporidium parvum through molecular modeling, docking, and dynamics simulation study J. Biomol. Struct. Dyn. Pub Date : 2020-07-07 Ajit Kumar Dhal; Alok Pani; Soon-IL Yun; Rajani Kanta Mahapatra
Calcium Dependent Protein Kinases are found in the Apicomplexan, algae, and plants; however, they are reported in vertebrates and are regarded as excellent drug targets for pharmaceutical interventions. Calcium Dependent Protein Kinases of Cryptosporidium are probably involved in the regulation of invasion and egress process during the infection of the host cells. The previous study reported that after
Correction notice J. Biomol. Struct. Dyn. Pub Date : 2020-07-07
(2020). Correction notice. Journal of Biomolecular Structure and Dynamics. Ahead of Print.
Screening of phytochemical compounds of Tinospora cordifolia for their inhibitory activity on SARS-CoV-2: an in silico study J. Biomol. Struct. Dyn. Pub Date : 2020-07-06 S. Krupanidhi; K. Abraham Peele; T. C. Venkateswarulu; Vijaya Sai Ayyagari; Md. Nazneen Bobby; D. John Babu; A. Venkata Narayana; G. Aishwarya
In the present study, we explored phytochemical constituents of Tinospora cordifolia in terms of its binding affinity targeting the active site pocket of the main protease (3CL pro) of SARS-CoV-2 using molecular docking study and assessed the stability of top docking complex of tinosponone and 3CL pro using molecular dynamics simulations with GROMACS 2020.2 version. Out of 11 curated screened compounds
Possibility of HIV-1 protease inhibitors-clinical trial drugs as repurposed drugs for SARS-CoV-2 main protease: a molecular docking, molecular dynamics and binding free energy simulation study J. Biomol. Struct. Dyn. Pub Date : 2020-07-06 Iruthayaraj Ancy; Mugudeeswaran Sivanandam; Poomani Kumaradhas
Initially, the SARS-CoV-2 virus was emerged from Wuhan, China and rapidly spreading across the world and urges the scientific community to develop antiviral therapeutic agents. Among several strategies, drug repurposing will help to react immediately to overcome the COVID-19 pandemic. In the present study, we have chosen two clinical trial drugs against HIV-1 protease namely, TMB607 and TMC310911 to
Design and screening of FAK, CDK 4/6 dual inhibitors by pharmacophore model, molecular docking, and molecular dynamics simulation J. Biomol. Struct. Dyn. Pub Date : 2020-07-06 Chuance Sun; Lijun Feng; Xiaohua Sun; Rilei Yu; Congmin Kang
Focal adhesion kinase (FAK) is one kind of tyrosine kinases that modulates integrin and growth factor signaling pathways, which is a promising therapeutic target because of involving in the migration, proliferation and survival of cancer cell. Overexpression and amplification of cyclin-dependent kinase 4/6 (CDK4/6) occur in many cancers and may be the cause of resistance to CDK4/6 inhibitors in preclinical
Classification of the COVID-19 infected patients using DenseNet201 based deep transfer learning J. Biomol. Struct. Dyn. Pub Date : 2020-07-03 Aayush Jaiswal; Neha Gianchandani; Dilbag Singh; Vijay Kumar; Manjit Kaur
Abstract Deep learning models are widely used in the automatic analysis of radiological images. These techniques can train the weights of networks on large datasets as well as fine tuning the weights of pre-trained networks on small datasets. Due to the small COVID-19 dataset available, the pre-trained neural networks can be used for diagnosis of coronavirus. However, these techniques applied on chest
Effect of novel leukemia mutations (K75E & E222K) on interferon regulatory factor 1 and its interaction with DNA: insights from molecular dynamics simulations and docking studies J. Biomol. Struct. Dyn. Pub Date : 2020-07-03 Balu Kamaraj; Abeer Mohammed Al-Subaie; Fazil Ahmad; Krishna Mohan Surapaneni; Khaldoon Alsamman
Interferon regulatory factor 1 (IRF-1) plays a vital role in cell proliferation and cell differentiation by acting as a tumor suppressor gene and its role is linked to various types of cancers, including leukemia and pre-leukemia myelodysplasia. Mutations in the coding region of the IRF-1 are likely to influence the IRF-1 and its DNA binding affinity. The molecular mechanism of the DNA recognition
Bacterial protein azurin and derived peptides as potential anti-SARS-CoV-2 agents: insights from molecular docking and molecular dynamics simulations J. Biomol. Struct. Dyn. Pub Date : 2020-07-03 Santanu Sasidharan; Chandrabose Selvaraj; Sanjeev Kumar Singh; Vikash Kumar Dubey; Sachin Kumar; Arsenio M. Fialho; Prakash Saudagar
The current pandemic SARS-CoV-2 has wreaked havoc in the world, and neither drugs nor vaccine is available for the treatment of this disease. Thus, there is an immediate need for novel therapeutics that can combat this deadly infection. In this study, we report the therapeutic assessment of azurin and its peptides: p18 and p28 against the viral structural S-protein and non-structural 3CLpro and PLpro
Epitope based peptide vaccine against SARS-COV2: an immune-informatics approach J. Biomol. Struct. Dyn. Pub Date : 2020-07-03 Richa Bhatnager; Maheshwar Bhasin; Jyoti Arora; Amita S. Dang
World is witnessing exponential growth of SARS-CoV2 and fatal outcomes of COVID 19 has proved its pandemic potential already by claiming more than 3 lakhs deaths globally. If not controlled, this ongoing pandemic can cause irreparable socio-economic and psychological impact worldwide. Therefore a safe and effective vaccine against COVID 19 is exigent. Recent advances in immunoinformatics approaches
In silico prediction of enzymatic reactions catalyzed by acid phosphatases J. Biomol. Struct. Dyn. Pub Date : 2020-07-02 Javad Zamani Amirzakaria; Mohammad Ali Malboobi; Sayed-Amir Marashi; Tahmineh Lohrasebi
In present work, we describe a methodology for prediction of an enzymatic reaction for which no experimental data are available except for a gene sequence. As a challenging case, we have developed the method for identifying the putative substrates of monoester phosphatases, commonly known as acid phosphatase enzymes, which have no strong substrate specificity. Finding a preferable substrate for each
In silico analysis and identification of promising hits against 2019 novel coronavirus 3C-like main protease enzyme J. Biomol. Struct. Dyn. Pub Date : 2020-07-01 Shilpa Chatterjee; Arindam Maity; Suchana Chowdhury; Md Ataul Islam; Ravi K. Muttinini; Debanjan Sen
The recent outbreak of the 2019 novel coronavirus disease (COVID-19) has been proved as a global threat. No particular drug or vaccine has not yet been discovered which may act specifically against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and causes COVID-19. For this highly infectious virus, 3CL-like main protease (3CLpro) plays a key role in the virus life cycle and can be considered
Development of triple mutant T790M/C797S allosteric EGFR inhibitors: a computational approach J. Biomol. Struct. Dyn. Pub Date : 2020-07-01 Kshipra S. Karnik; Aniket P. Sarkate; Deepak K. Lokwani; Ishudeep S. Narula; Prasad V. L. S. Burra; Pravin S. Wakte
The mutations concerned with non-small cell lung cancer involving epidermal growth factor receptor of tyrosine kinase family have primarily targeted. EGFR inhibitors binding allosterically to C797S mutant EGFR enzyme have been developed. Here, database building, library screening performing R-group enumeration and scaffold hopping technique for increasing the EGFR binding affinity of compounds have
On interactions of P-glycoprotein with various anti-tumor drugs by binding free energy calculations J. Biomol. Struct. Dyn. Pub Date : 2020-07-01 Bo Zhang; Junqiao Zhang; Zhengzhong Kang; Lijun Liang; Yingchun Liu; Qi Wang
P-glycoprotein (P-gp, MDR1), one of ATP-binding cassette transporters, may confer tumor cells cross-resistance to chemotherapeutics. A large amount of P-gp inhibitors were designed to inhibit the multidrug resistance (MDR) feature of P-gp. However, no sufficient researches were reported to explore the correlation between binding capacity and drug property by experiment. Without particular drug property
Rational design of 9-vinyl-phenyl noscapine as potent tubulin binding anticancer agent and evaluation of the effects of its combination on Docetaxel J. Biomol. Struct. Dyn. Pub Date : 2020-07-01 Shruti Gamya Dash; Charu Suri; Praveen Kumar Reddy Nagireddy; Srinivas Kantevari; Pradeep Kumar Naik
Docetaxel (DOX) based combination therapy is a novel therapeutic strategy that attracts great interest in breast cancer treatment but its clinical utility got limited due to side effects. In contrast, noscapine, an antitussive drug showed antitumor activity against many cancers without any side effects that targets microtubules and attenuates its dynamic instability. In the quest for an increase in
Prunus amygdalus extract exert antidiabetic effect via inhibition of DPP-IV: in-silico and in-vivo approaches J. Biomol. Struct. Dyn. Pub Date : 2020-06-30 Vikas Kumar; Richa Sachan; Mahfoozur Rahman; Kalicharan Sharma; Fahad A. Al-Abbasi; Firoz Anwar
Prunus amygdalus (PA) is a popular invasive seed utilized in the management of diabetes in Jammu and Kashmir, India. The objective of the current study was to scrutinize the antidiabetic effect of Prunus amygdalus (PA) against Streptozotocin (STZ) induced diabetic rats and explore the possible mechanism of action at cellular and sub-cellular levels. Box Benkan Design (BBD) was performed to determine
Molecular insights into benzene sulphonamide substituted diarylpyrazoles as cyclooxygenase-2 inhibitor and its structural modifications J. Biomol. Struct. Dyn. Pub Date : 2020-06-30 D. Priya; M. K. Kathiravan
Quantitative Structure Activity Relationship (QSAR) is one of the realistic and most successful methods for drug design in optimizing a lead. A series of forty-four molecules from diarylpyrazole benzene sulphonamide derivatives with their cyclooxygenase-2 inhibitory activity were subjected to qsar studies using QSARINS software. The significant two descriptor qsar model generated showed correlation
Computational analysis identifies druggable mutations in human rBAT mediated Cystinuria J. Biomol. Struct. Dyn. Pub Date : 2020-06-30 Bharati Pandey; Murali Aarthy; Mahima Sharma; Sanjeev Kumar Singh; Vinay Kumar
Culex quinquefasciatus Cqm1 protein acts as the receptor for Lysinibacillus sphaericus mosquito-larvicidal binary (BinAB) toxin that is used worldwide for mosquito control. We found amino acid transporter protein, rBAT, as phylogenetically closest Cqm1 homolog in humans. The present study reveals large evolutionary distance between Cqm1 and rBAT, and rBAT ectodomain lacks the sequence motif which serves
Synthesis, characterization, theoretical, molecular docking and in vitro biological activity studies of Ru(II) (η6-p-cymene) complexes with novel aniline substituted aroyl selenoureas J. Biomol. Struct. Dyn. Pub Date : 2020-06-29 Moideen Musthafa; Ramaiah Konakanchi; Rakesh Ganguly; Chandrasekar Balachandran; Shin Aoki; Anandaram Sreekanth
A sequence of aroyl selenourea ligands (L1–L3) substituted by aniline and their Ru(II) (η6-p-cymene) complexes (1-3), [Ru(II) (η6-p-cymene) L] (L = monodentate aroyl selenourea ligand) have been synthesized and characterized the composition of the ligands and their metal complexes. The molecular structures of ligand L1 and complex 3 were also confirmed by single XRD crystal method. The single-crystal
Synthesis, crystal structure, Hirshfeld surface analysis, DNA binding, DNA cleavage activity and molecular docking of a new Schiff base nickel(II) complex J. Biomol. Struct. Dyn. Pub Date : 2020-06-29 Jianfang Dong; Lei Gao; Bo Zhang; Tao Xu; Lei Wang; Jinming Kong; Lianzhi Li
A mononuclear nickel(II) complex, [Ni(o-van-tris)2]·2H2O (o-van-tris = Schiff base derived from o-vanillin and tris(hydroxymethyl)aminomethane), has been synthesized and structurally characterized. The single crystal structure shows a distorted octahedron geometry coordinated with Ni(II) atom, and 2 D plane structure has formed by O–H···O hydrogen bond interactions. An analysis to ascertain intermolecular
Repurposing of FDA-approved antivirals, antibiotics, anthelmintics, antioxidants, and cell protectives against SARS-CoV-2 papain-like protease J. Biomol. Struct. Dyn. Pub Date : 2020-06-29 Mahmoud Kandeel; Alaa H. M. Abdelrahman; Kentaro Oh-Hashi; Abdelazim Ibrahim; Katharigatta N. Venugopala; Mohamed A. Morsy; Mahmoud A. A. Ibrahim
SARS-CoV-2 or Coronavirus disease 19 (COVID-19) is a rapidly spreading, highly contagious, and sometimes fatal disease for which drug discovery and vaccine development are critical. SARS-CoV-2 papain-like protease (PLpro) was used to virtually screen 1697 clinical FDA-approved drugs. Among the top results expected to bind with SARS-CoV-2 PLpro strongly were three cell protectives and antioxidants (NAD+
Synthesis and docking studies of three new diaminochromenes as potential leads for anticancer drugs J. Biomol. Struct. Dyn. Pub Date : 2020-06-29 Mariana de Oliveira Tonelli Nogueira; Joyce Sobreiro Francisco Diz de Almeida; Tanos Celmar Costa Franca; José Daniel Figueroa-Villar
In this work, the new diaminochromenes: 2,5-dimono-8-methoxychromeno[4,3,2-de][1,6]naphthyridine-4-carbonitrile (4), 8-ethoxy-2-imino-3,4-dihydro-2H-chromene-3-carbonitrile-4-malononitrile (5), 2,5-diamino-8-ethoxychromene[4,3,2-de][1,6]naphthyridine-4-carbonotrile (6), were synthesized and fully characterized through 600 MHz using 1H, 13C, APT, gHSQC, gHMBC, ROESY-1D and gated decoupling 13C. Further
Molecular profiling of lamellar ichthyosis pathogenic missense mutations on the structural and stability aspects of TGM1 protein J. Biomol. Struct. Dyn. Pub Date : 2020-06-29 Khalidah Khalid Nasser; Babajan Banaganapalli; Thoraia Shinawi; Ramu Elango; Noor Ahmad Shaik
Lamellar ichthyosis (LI) is a rare inherited disease where affected infants present a extensive skin scaling characterized by hyperkeratosis. Inherited mutations in the Transglutaminase 1 (TGM1) protein is one of the known causative genetic factor for the LI. The main objective of this study is to explore the impact of LI causative missense mutations on the structural and stability aspects of TGM1
Structure based design of inhibitory peptides targeting ornithine decarboxylase dimeric interface and in vitro validation in human retinoblastoma Y79 cells J. Biomol. Struct. Dyn. Pub Date : 2020-06-27 Sivashanmugam Muthukumaran; K. N. Sulochana; Vetrivel Umashankar
Polyamine synthesis in human cells is initiated by catalytic action of Ornithine decarboxylase (ODC) on Ornithine. Elevated levels of polyamines are manifested proliferating cancer cells and are found to promote tumour cell adhesion. Di-flouro methyl orninthine is a known inhibitor of ODC, however its usage is limited due its low affinity quick clearance and incompetent cellular uptake, thus posing
Computational modeling of transforming growth factor β and activin a receptor complex formation in the context of promiscuous signaling regulation J. Biomol. Struct. Dyn. Pub Date : 2020-06-27 Stephen M. Farmer; Claudia D. Andl
The Transforming growth factor-beta (TGFβ) superfamily is a group of multipotent growth factors that control proliferation, quiescence and differentiation. Aberrant signal transduction and downstream target activation contribute to tumorigenesis and targeted therapy has therefore been considered a promising avenue. Using various modeling pipelines, we analyzed the structure-function relationship between
Development of methylthiosemicarbazones as new reversible monoamine oxidase-B inhibitors for the treatment of Parkinson's disease J. Biomol. Struct. Dyn. Pub Date : 2020-06-26 Githa Elizabeth Mathew; Jong Min Oh; Kumar Mohan; Anandkumar Tengli; Bijo Mathew; Hoon Kim
Selective monoamine oxidase-B (MAO-B) inhibition is an attractive subject for the treatment of Parkinson's disease (PD). In the current study, we synthesized some selected derivatives of methylthiosemicarbazones and investigated their MAOs and acetylcholinesterase (AChE) inhibitory activities. Among the series synthesized, compounds SM5, SM4, and SM9 most inhibited MAO-B with IC50 values of 5.48, 7
Multispectroscopic analysis, atomic force microscopy, molecular docking and molecular dynamic simulation studies of the interaction between [SnMe2Cl2(Me2phen)] complex and ct-DNA in the presence of glucose J. Biomol. Struct. Dyn. Pub Date : 2020-06-26 Nahid Shahabadi; Mohammad Mahdavi; Badri Z. Momeni
In this study, the spectroscopic methods (UV–vis, fluorimetric), Atomic force microscopy, and computational studies (molecular docking and molecular dynamic simulation) were used to investigate the interaction of [SnMe2Cl2(Me2phen)] complex with CT-DNA in the presence of glucose. The results showed the complex in the medium containing glucose has less effect on calf thymus DNA (ct-DNA) than the medium
In silico screening of glycogen synthase kinase-3β targeted ligands against acetylcholinesterase and its probable relevance to Alzheimer's disease J. Biomol. Struct. Dyn. Pub Date : 2020-06-26 Nasimudeen R. Jabir; Shazi Shakil; Shams Tabrez; Mohd Shahnawaz Khan; Md Tabish Rehman; Bakrudeen Ali Ahmed
Alzheimer's disease (AD) is a growing global health concern that affects 10% of the population aged above 65 years. A growing body of evidence indicates that multi-targeted drugs might be useful therapeutic options owing to the heterogeneity of AD pathology. The current study exploited advanced computational biology tools to identify ligands that might display effective binding to two protein targets
Immunoinformatics study to search epitopes of spike glycoprotein from SARS-CoV-2 as potential vaccine J. Biomol. Struct. Dyn. Pub Date : 2020-06-25 Ramírez-Salinas Gema Lizbeth; García-Machorro Jazmín; Correa-Basurto José; Martínez-Archundia Marlet
The Coronavirus disease named COVID-19 is caused by the virus reported in 2019 first identified in China. The cases of this disease have increased and as of June 1st, 2020 there are more than 216 countries affected. Pharmacological treatments have been proposed based on the resemblance of the HIV virus. With regard to prevention there is no vaccine, thus, we proposed to explore the spike protein due
Alzheimer's disease: unraveling APOE4 binding to amyloid-beta peptide and lipids with molecular dynamics and quantum mechanics J. Biomol. Struct. Dyn. Pub Date : 2020-06-25 Jean-Numa Gillet
The apolipoprotein E (APOE) involved in lipid metabolism participates in the clearance and deposition of the amyloid-beta peptide of the Alzheimer's disease (AD). The isoform APOE4 with the ARG112 mutation is the main genetic risk for the late-onset AD. Herein, using both molecular dynamics and quantum mechanics, the binding mechanisms of APOE4 leading to the AD are unraveled and now available for
In silico structure prediction, molecular docking and dynamic simulation studies on G Protein-Coupled Receptor 116: a novel insight into breast cancer therapy J. Biomol. Struct. Dyn. Pub Date : 2020-06-25 Indiraleka Muthiah; Karthikeyan Rajendran; Premnath Dhanaraj; Sugumari Vallinayagam
G Protein-Coupled Receptor gains more importance in cancer research; because of their key role in several physiologic functions of cells. However, most of the GPCR's are orphan receptors, this hampers the finding of drugs against GPCR. G Protein-Coupled Receptor 116 is an adhesion orphan receptor that intensifies the invasion of cells in Triple-Negative Breast Cancer. In this study, existing FDA approved
Fingerprint-based similarity search identified p-anisidine as an anticancer agent in HeLa and a prospective phytochemical ETV1 transcription factor inhibitor J. Biomol. Struct. Dyn. Pub Date : 2020-06-25 Ambily Nath IV; Achuthsankar S. Nair
Overexpression of E26 transformation-specific (ETS) PEA3 subfamily transcription factor (TF) ETV1 is reportedly oncogenic and metastatic in several cancers. Albeit, a few synthetic small molecule inhibitors of ETV1 have been identified to date. In this context, we hereby proposed a phytochemical lead development scheme to gather inhibitor scaffolds for ETV1. A fingerprint-based similarity search was
Locating the binding sites of citric acid and gallic acid on milk β-lactoglobulin J. Biomol. Struct. Dyn. Pub Date : 2020-06-24 P. Chanphai; H. A. Tajmir-Riahi
β-Lactoglobulin (β-LG) is a member of lipocalin superfamily of transporters for small hydrophobic and hydrophilic molecules. We located the binding sites of citric acid and gallic acid on β-lactoglobulin (β-LG) in aqueous solution at physiological conditions, using spectroscopic methods, thermodynamic analysis and molecular modeling. Thermodynamic parameters ΔH0 −9.5 to −6.9 (kJ mol−1), ΔS0 23.9 to
Binding insight of clinically oriented drug famotidine with the identified potential target of SARS-CoV-2 J. Biomol. Struct. Dyn. Pub Date : 2020-06-24 Parth Sarthi Sen Gupta; Satyaranjan Biswal; Dipankar Singha; Malay Kumar Rana
Communicated by Ramaswamy H. Sarma
Zika virus envelope – heat shock protein A5 (GRP78) binding site prediction J. Biomol. Struct. Dyn. Pub Date : 2020-06-24 Abdo A. Elfiky; Ibrahim M. Ibrahim
Recent studies reported the association of the Zika virus (ZIKV) with a stress response receptor on the host cell membrane that facilitates viral entry. This host receptor was the heat shock protein A5 (HSPA5), also termed glucose-regulating protein 78 (GRP78). In this study, structural bioinformatics and molecular dynamics simulations were utilized to suggest the binding site of ZIKV envelope protein
Identification of luteolin -7-glucoside and epicatechin gallate from Vernonia cinerea, as novel EGFR L858R kinase inhibitors against lung cancer: Docking and simulation-based study J. Biomol. Struct. Dyn. Pub Date : 2020-06-24 Priyanka Maiti; Mahesha Nand; Tushar Joshi; Muthannan Andavar Ramakrishnan; Subhash Chandra
Lung cancer ranks number one among the all cancer types in the world, out of which 85% are non-small cell lung cancer (NSCLC). In case of NSCLC, a substitution mutation of Leu 858 Arg (L858R) in the gene of Epidermal Growth Factor Receptor (EGFR) has been reported. Hence, targeting EGFR containing L858R mutation using inhibitors is well reported strategy to discover potential drugs against NSCLC. The
In-silico investigation of phytochemicals from Asparagus racemosus as plausible antiviral agent in COVID-19 J. Biomol. Struct. Dyn. Pub Date : 2020-06-24 Rupesh V. Chikhale; Saurabh K. Sinha; Rajesh B. Patil; Satyendra K. Prasad; Anshul Shakya; Nilambari Gurav; Rupali Prasad; Suhas R. Dhaswadikar; Manish Wanjari; Shailendra S. Gurav
Abstract COVID-19 has ravaged the world and is the greatest of pandemics in human history, in the absence of treatment or vaccine the mortality and morbidity rates are very high. The present investigation was undertaken to screen and identify the potent leads from the Indian Ayurvedic herb, Asparagus racemosus (Willd.) against SARS-CoV-2 using molecular docking and dynamics studies. The docking analysis
High-throughput virtual screening approach involving pharmacophore mapping, ADME filtering, molecular docking and MM-GBSA to identify new dual target inhibitors of PfDHODH and PfCytbc1 complex to combat drug resistant malaria J. Biomol. Struct. Dyn. Pub Date : 2020-06-24 Ravi Rawat; Saurabh M. Verma
Emerging cases of drug resistance against Artemisinin combination therapies which are the current and the last line of defense against malaria makes the situation very alarming. Due to the liability of single-target drugs to be more prone to drug resistance, the trend of development of dual or multi-target inhibitors is emerging. Recently, a malaria box molecule, MMV007571 which is a well known new
In-silico identification of fingerprint of pyrazolyl sulfonamide responsible for inhibition of N-myristoyltransferase using Monte Carlo method with index of ideality of correlation J. Biomol. Struct. Dyn. Pub Date : 2020-06-24 Ashwani Kumar; Jayant Sindhu; Parvin Kumar
Human African trypanosomiasis (HAT) or sleeping sickness like infections remain a serious health concern around the globe due to unavailability of safe and potential drugs for their treatment. Moreover, developing safe, potential and highly specific target based treatments is still a challenge for present drug discovery programs. A series of pyrazole based sulfonamides are identified as an inhibitor
Five new complexes with deferiprone and N,N-donor ligands: evaluation of cytotoxicity against breast cancer MCF-7 cell line and HSA-binding determination J. Biomol. Struct. Dyn. Pub Date : 2020-06-24 Fatemeh Delavar Mendi; Amir Sh. Saljooghi; Mohammad Ramezani; Rafal Kruszynski; Morgane Poupon; Monika Kucerakova; Volker Huch; Pawel Socha; Maryam Babaei; Mona Alibolandi
In this study, five new complexes containing deferiprone (dfp) and N,N-donor ligands [bipyridine (bpy), 1,10-phenanthroline (phen) and ethylenediamine (en)] were synthesized: [Fe(dfp)2(bpy)](PF6) (1), [Fe(dfp)2(phen)](PF6) (2), [Cu2(dfp)2(bpy)2](PF6)2 (3), [Ga(dfp)2(bpy)](PF6) (4), and [Fe(dfp)2(en)](PF6) (5). Characterization of these complexes was carried out through elemental analysis and FT-IR
Bis-indole alkaloid caulerpin from a new source Sargassum platycarpum: isolation, characterization, in vitro anticancer activity, binding with nucleobases by DFT calculations and MD simulation J. Biomol. Struct. Dyn. Pub Date : 2020-06-24 Doaa A. Abdelrheem; H. R. Abd El-Mageed; Hussein S. Mohamed; Aziz A. Rahman; Khaled N. M. Elsayed; Sayed A. Ahmed
Caulerpin, a bis-indole alkaloid is isolated from a new source Sargassum platycarpum, brown alga (family Sargassaceae) for the first time. The structure of caulerpin was characterized by IR, H1NMR, C13 NMR, HSQC, HMBC, EI-MS spectroscopy. Antifungal results suggest that caulerpin has been inhibited Cryptococcus neoformas (12 mm) and Candida albicans (7 mm) than other microbes. In vitro anticancer activity
Computational investigation on the effects of pharmaceutical polymers on the structure and dynamics of interleukin2 in heat stress J. Biomol. Struct. Dyn. Pub Date : 2020-06-24 Sajad Moradi; Saba Mirzaei; Rasool Khosravi; Negin Farhadian; Elnaz Hosseininezhadian koushki; Mohsen Shahlaei
Application of proteinous drugs can be associated with difficulties during both in storage/transportation and in the body when they are used. However, using pharmaceutical carbohydrates that are widely employed in drug delivery systems, besides the drug can be protected, these systems leading to gradually release the drug over time, or deliver it to the target cell. Using a combination of molecular
Pharmacoinformatics and molecular dynamics simulation studies reveal potential covalent and FDA-approved inhibitors of SARS-CoV-2 main protease 3CLpro J. Biomol. Struct. Dyn. Pub Date : 2020-06-24 Mubarak A. Alamri; Muhammad Tahir ul Qamar; Muhammad Usman Mirza; Rajendra Bhadane; Safar M. Alqahtani; Iqra Muneer; Matheus Froeyen; Outi M. H. Salo-Ahen
The SARS-CoV-2 was confirmed to cause the global pandemic of coronavirus disease 2019 (COVID-19). The 3-chymotrypsin-like protease (3CLpro), an essential enzyme for viral replication, is a valid target to combat SARS-CoV and MERS-CoV. In this work, we present a structure-based study to identify potential covalent inhibitors containing a variety of chemical warheads. The targeted Asinex Focused Covalent
Screening of Chloroquine, Hydroxychloroquine and its derivatives for their binding affinity to multiple SARS-CoV-2 protein drug targets J. Biomol. Struct. Dyn. Pub Date : 2020-06-24 Mallikarjuna Nimgampalle; Vasudharani Devanathan; Ambrish Saxena
Recently Chloroquine and its derivative Hydroxychloroquine have garnered enormous interest amongst the clinicians and health authorities' world over as a potential treatment to contain COVID-19 pandemic. The present research aims at investigating the therapeutic potential of Chloroquine and its potent derivative Hydroxychloroquine against SARS-CoV-2 viral proteins. At the same time screening was performed
In silico identification of therapeutic compounds against microRNA targets in drug-resistant pancreatic ductal adenocarcinoma J. Biomol. Struct. Dyn. Pub Date : 2020-06-24 Imlimaong Aier; Rahul Semwal; Anju Sharma; Pritish Kumar Varadwaj
Pancreatic ductal adenocarcinoma (PDAC) is a major health issue that has been eluding efforts to identify viable therapeutic treatment options. Besides having the lowest survival rate among all types of cancer, almost all conventional methods of treatment are futile against this condition, leaving patients to succumb to this ailment faster than ever. As it is increasingly becoming difficult to come


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- Joined
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- Acer Aspire XC-605
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I made the USB, plugged it in to my computer, and the USB would only show up as bootable in the BIOS if it was made in Legacy Mode. The issue is it didn't create an EFI Partition (And i can not Install Clover). Because of this I want to install it as UEFI. Windows already Initialized the Disk because I formatted it as Apple Partition Map, so i can't boot into Sierra again. The install was successful though, and with the help of a little trick (Press the Exit Clover Button, Drops me to some strange EFI Menu, Select Boot Manager or Something like that, EFI USB) with the Legacy Mode USB, and i was successful in getting the Internet Drivers Working.

subset: commoncrawl


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Blackland Prairie Rapter Center Update
Photos courtesy – Erich Neupert
An impressive percentage of our BPTMN tribe volunteers at the Blackland Prairie Raptor Center which has taken positive measures to keep the center in operation and the volunteers safe through modified schedules.
As of June 18 Raptor Center rehab has treated 275 birds.
By species:
Now here is the fun. Who can tell us what the abbreviations stand for.
HINT that will help: https://bpraptorcenter.org/
Under Rescue – Raptor Med
Sixty-three have been released but many are in flight activity areas learning to catch their own prey, which is the requirement for releasing.
Release rate? 80 percent.
Baume's Connemara Videos
There is an old song; How High is the Water Mama? Well, Al Baume and Bob Milne were at Rowlett Creek in Connemara to verify. Vines, stuff and part of a bridge came through.
Find out more –
Laurie Sheppard: On the road again.
Laurie has been staying home for the past couple of weeks and will be careful on the way north, to New Hampshire. We hope the stops along the way will be safe, and she has masks, gloves, and hand sanitizer with her.
Till we see her again she gave us some wonderful Hagerman pics.
Happy Summer Solstice, everyone – Laurie
Shaking the Trees 4th Edition 05/15/20
Bird birthing updates, Duane's cool labyrinth, news from a New Mexico naturalist you may know and grass and forbs contest ready for viewing. Keep the info coming folks. You are making many people very happy by sharing your time in nature.
Terry Comingore – Proud Grandpa of Heron Chicks
Jim Dulian – Backyard Heron Nest
Greg Hayden – Greetings from New Mexico
Duane Mortenson – Lockdown in Backyard Oasis
Clyde Camp WildLife Blog
Jim Dulian's – Grasses & Forb Quiz
The response and number of hits to the site from our members has been remarkable, y'all. Keep the experiences and joys coming and remember that if you have some needs we can meet, give us a holler. What you have continued to accomplish during this unfamiliar part of our journeys is amazing!
Nature Reflections Video Exercise
Texas Master Naturalists,
A small victim of this current quarantine and shelter in place is the missed opportunities of spring. So many of our Master Naturalist volunteer service projects literally take bloom during these spring months each year – we have a new crop of trainees joining in some chapters, plant sales and plantings of native butterfly gardens, youth education programs as Texas students cycle into earth sciences in the spring, bird and butterfly migrations, and so much more that isn't able to happen in its traditional form right now!
To that end, I would like as many of you as possible to respond to this statement: "In this unprecedented moment of the pandemic, reflect upon what nature means to you and what benefits it provides you, especially in times like these."
If you have any questions or concerns, please let me know. While this is a video exercise, if you would rather share your written thoughts, a meaningful poem or quote relevant to this task, and/or a nature photo you took, please share those as well!
Again, stay safe and healthy, and thank you for your participation in this exercise! It'll be so nice to hear your voices and see your faces at this moment in time!
Mary Pearl
Mary Pearl Meuth
Texas Master Naturalist Program Assistant State Coordinator
Texas A&M AgriLife Extension Service
E-mail: email@example.com
Shaking the Trees 3rd Edition 05/01/20
Laurie Sheppard – Rare skipper at Hagerman NWR
Dave Powell – Walking and healing his wing
Clyde Camp – Owl Blog Surprise coming through in the clutch
John Garbutt – Woodpecker wonders
Dick Zartler – Fire on the prairie is success
Deborah Canterbury – Insect "didja-knows"
Paul Napper – East Texas Live
Terry Comingore – Blue Heron update
Mikel Salsgiver: Once a Teacher…
Beverly Carpenter – It's baby season!
Trip to Botanical Institute of Texas
Members of our BPTMN Chapter visited the Botanical Research Institute of Texas (aka BRIT) in Fort Worth. BRIT houses several herbariums (collection of dried plants), seed bank, botanical art collections, children/ adult classes, educator programs and more.
Visit their site to learn more and support this valuable resource.
Hagerman National Wildlife Refuge – After The Flood
by Laurie Sheppard
May, 2017 marks two years since heavy rains caused damaging flooding at Hagerman National Wildlife Refuge and other parts of north Texas. By May 10, 2015, many roads on the refuge were impassable and public access was curtailed. Ultimately, 9,000 of the refuge's 11,320 acres were under water. It was August before the main roads were fully exposed and repairs could begin. At its worst, parts of the refuge were under as much as 24 feet of water, displacing wildlife and causing permanent changes to some habitats.
Rainfall totals along the Red River can vary greatly and periods of flood often follow seasons of drought. Such was the case starting in 2015. Three years of markedly reduced rainfall had left Lake Texoma's conservation pool several feet below normal but spring rains filled the lake and kept on coming. The water receded in the fall, but a second closure of the refuge occurred in December, 2015 and a third in May and June, 2016.
Flooding can have a positive impact on fisheries by bringing water to areas of woody or herbaceous habitat for fish to feed and spawn. The spring floods of 2015 may have been too late for spawning, but observations by anglers seem to indicate an increase in survival by some valued species. On the other hand, some of the larger sport fish were released downstream when the Denison Dam floodgates were open for several weeks. Flooding also brings with it a large influx of sediment, filling in portions of the lake creating shallows where Carp and Gar species flourish, but also adding nutrients that fuel the microscopic plants and animals at the base of the aquatic food chain.
The deer population at Hagerman NWR appeared to move to higher ground in the summer of 2015 and then return as the waters receded. The refuge performs a deer census each fall, following the same route over multiple days, so they have decades of data with which to compare. The deer count in 2015 did not vary greatly from previous years, which was very encouraging. However, in 2016, the flooding occurred at birthing time and the number of surviving fawns identified was much lower.
Birders noticed a reduction in raptors in the winter of 2015-16. Barred Owls that had previously nested in known areas were no longer seen or heard but seem to be gradually returning. The Friends of Hagerman NWR organization has tracked Bluebird nesting for several years. Volunteers check nest boxes weekly throughout the refuge. In 2014, 272 Eastern Bluebirds fledged. Nest box monitoring was halted mid-season in 2015 when the nesting areas flooded. Some nest boxes spent weeks underwater but when access was restored volunteers saw others with new nests built on top of old nests. Only 103 fledglings were counted in 2015, and with a smaller flood in 2016, 152 bluebirds fledged.
The largest impact identified in these past two years is to hardwoods, especially oak trees, which notoriously don't do well with prolonged "wet feet". Many trees have died, changing the landscape, which will affect the mix of wildlife in the long term. The public responded to a plea for acorns in the fall of 2015 and thousands were planted by volunteers, but then more floods occurred. It will be a few more years before it is well known what the long term impacts will be. Change is constant but nature will prevail.


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Warning: Late repayments can cause you serious money problems. For help, go to moneyadviceservice.org.uk
Representative Example: On an assumed loan amount of £750 over 12 months. Rate of interest 292% (fixed). Representative 171%APR. Total repayment amount £1351.20 and total interest is £601.20. 12 monthly payment of £112.60.** We do not know how many customers take out a loan or the APR, this calculation is based on the mean APR of the lenders we work with
No guarantor loans are a type of unsecured loan that don't require you to find a family member or friend to co-sign the loan. Applying for a no guarantor loan means you are able to apply to borrow money without a finding a guarantor to complete the loan application.
Loans without a guarantor are commonly used for personal, lifestyle and emergency purposes. This includes things like weddings, new cars, business requirements and even more pressing things like debt consolidation, household emergencies and vehicle repairs.
When you're in urgent need of cash you can apply for a loan with no guarantor. This means another party is not required to agree to you borrowing from a lender. A short term loan where no guarantor is needed could be a suitable option for you if you're unable to find somebody to help if you can't cover the repayments yourself.
To get a loan without a guarantor, you should first avoid applying with certain lenders and brokers that exclusively work with direct guarantor lenders. Next you should see what your options are: if you have a good credit score, you may be able to get a personal loan from high street bank or an online lender.
However if you have poor credit history, then getting a loan without a guarantor is more difficult. You may want to consider a short term loan or a bad credit personal loan, both of which come with a higher APR, but without the need for a friend or family to cosign the loan agreement for you.
At My Financial Broker, we can find you a lender online that offers loans without a guarantor!
You may have the option to repay your loan early from one of our partners, and you will typically save money for doing so because you have accrued less interest overall.
There are many types of non-guarantor loans for different situations and people of varying credit histories. When you apply for a loan without a guarantor required, you are just working directly with the lender and there is more financial freedom. These some of the types of credit you can get that don't require someone to cosign the loan agreement:
Finding a loan with or without a guarantor can be challenging if you have bad credit, as there are fewer options available to you. We work with several direct lenders who consider loan applications from people with bad credit.
Our partners do not expect customers to have a perfect credit score, but instead want to see a steady flow of income, a regular employment, and a desire to make future payments on time.
Lenders understand that many people do have a poor credit score and need to borrow money with a guarantor, so if you can demonstrate your affordability and can prove you have a record of making repayments on time, you are much more likely to be approved.
Sometimes finding a friend or family member to agree to being a guarantor can be difficult, since you need someone who is willing to back you financially and agree to make payments if you default. When applying for a loan, you have peace of mind knowing that you are not burdening another person to be your guarantor or being pressured. By working with the direct lender, you feel more in control of your money and the entire process from start to finish.
Loans that don't need a guarantor are typically paid out on the same day, and sometimes within 1 hour of approval. When you need to borrow money online you can apply for payday loans with no guarantor. Once you have completed the application process on our website and have been matched with a lender, there will be some final checks to verify your eligibility.
This includes some basic credit checks and affordability checks to confirm that you can afford the loan without failing into financial difficulty. Once successfully approved, the lenders we work with will usually have access to a faster payment system and can transfer funds to your bank account immediately.Apply Now


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Investing ideas
Investing in automation in a changing world
Growth in automation is being driven by many factors, including social distancing.
How much am I paying for my bonds?
You may be surprised by how mark-ups vary—and how they impact yields.
Tips from Fidelity pros: Megatrends to watch
Nidhi Gupta remains cautious on parts of tech, but sees continued growth tied to 2 megatrends.
Investing strategies
Looking for income?
Multi-asset strategies may help investors generate income despite low interest rates and bad economic news.
How might today's stimulus shape the future?
History suggests where zero interest rates and big spending may lead.
When bonds go bad
Learn what you can do if the issuer of bonds you own declares bankruptcy.
Bond markets
Get our latest thinking on the market, the outlook for rates, and investment strategies.
Planning & Guidance
Review and evaluate different investment strategies.Visit our Planning & Guidance Center
Past performance is no guarantee of future results.
Investing involves risk, including risk of loss.


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Monthly Archives: March 2017
Audiences and Users
Throughout the semester, I have thrown these words around carelessly, acting as if one could be replaced with the other. Though they are not interchangeable yet, many of this week's readings have shown that maybe we are heading in a … Continue reading
Posted in Blog 2 Comments
Access to Digital Humanities in Danger?
Our readings this week discussed the digitization of material that theoretically make information and knowledge more accessible to the public. I say theoretically because in practice various institutions are constrained with funding and publication contracts so they cannot digitize a … Continue reading
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Another Farm-book
Last weeks readings illuminated the laborious process that is archival construction. It is not so much the construction of the archive that is troublesome but the meticulous collection of metadata and the arrangement of it in a format that is culturally … Continue reading
Same Old BS Different Medium
Boyd, Sample and Park reiterate the themes race, class, inequality, oppression, racism, labels…. (I'm sure I'm missing a few) and apply these themes to social networks and communities. Boyd focuses on the separation of society onto two major social … Continue reading
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Lower than a month after Atatiana Jefferson was shot and killed in her own residence by a police officer, her father has handed away of a coronary heart assault. Marquis Jefferson was 58 years outdated.
Its simply unhappy due to grief. I dont know what else to say," household spokesman Bruce Carter informed native information. Lower than a month in the past, he was working at El Centro, mentoring youngsters twice every week. He simply couldnt get again from what occurred along with his daughter.
Atatiana Jefferson was taking part in video video games along with her nephew when police confirmed up at her home, having been referred to as by a neighbor for a wellness verify who observed her entrance door was open. Officer Aaron Dean noticed Jefferson's silhouette within the window and opened hearth with out figuring out himself as a cop, killing her. The taking pictures sparked nationwide requires justice which led to Dean's resignation.
He has been charged with homicide.
After her demise, Marquis Jefferson informed reporters that he had a mission to satisfy.
Its been very powerful," he informed WFAA on the time. Tay needed me to be sturdy. I've to be sturdy. My mission shouldn't be over.


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Organ donors are the greatest gift of all!
You "gave me a chance to stay".
To be a donor
You will be the answer
To a prayer
When you are gone.
Craig "Razor" Williams is a 72 year old rocker with a message in his music.
Singer songwriter drummer and in his own words "It's my fourth liver and I have three kidneys". A line in "Love & Destruction cries out "I never would imagine in my wildest dreams, living to be cured of what's been killing me" delivers the passion of his mission.
"I'm still here because someone cared".
"My prayer is for everyone to be a donor".
Razor, a nic in the Hayman Drum Company (73-74) lived in Stage-4 liver failure (2000) attributed to his military service, until a third transplant (2013) found the perfect fit. "The doc asked me "would you be happy with five years" just before my first transplant in 2000".
It is an amazing story. I am a donor because of it. .. Paul R.
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Comparison of Roman and Greek Architecture Architecture has been a fundamental cornerstone for building societies throughout the entire human development. Architecture in general is constantly changing but the ideas that have been formulated tend to come back and influence the next. They say those who forget history are doomed to repeat it and we can see how we are constantly repeating ourselves in terms of architecture.
We will write a custom essay sample on Comparison of Roman and Greek Architecture or any similar topic only for you. I shall compare and contrast the Greek and Roman ideal styles of architecture, by breaking down both of their discoveries and similarities. Greek architecture has several qualities that mark its work as a fundamental cornerstone in architecture. The Greeks had introduced several interesting factors; the scale of building was now proportioned to that of the human body.
Greek architecture had a seemingly positive outlook on things, unlike its predecessors like the Egyptians which brought out the death in architecture. In addition, the exterior has flying buttresses for pressure displacement with niches decorated using sculptures, pointed arches for increasing stability and strength , ribbed vaults and large windows with stained glass which allowed a lot of light into the cathedral.
Thinner columns were used to support its walls and the soaring height conveyed a sense of divinity. The two artworks have experienced changes and advancements as the years progressed. With the introduction of the Gothic architecture, the Romanesque architecture took a back seat as many builders adopted this new style. However, some buildings were still constructed using it, such as the Natural History Museum constructed in in London.
Moreover, revival churches erected using this architecture are also in existence and were put up from onwards.
Brunelleschi and The Romans: A Comparison of Technique Essay
The Gothic style has been widespread due to its strength and flexibility in construction and most of the buildings erected using this architecture still stand up to date. For example, the Chartres cathedral has maintained its original design, stained glass windows and sculptures with several additions over the years. Buildings constructed from the Gothic were tall with pointed arches and had a lot of light streaming into the cathedral and these symbolized divinity or getting closer to God.
The Gothic architecture succeeded the Romanesque architecture and inherited most of the stylistic features of Romanesque. One of the major analogous features of these two artworks is the purpose of the buildings. Both served as religious or worship places where the poverty stricken people and pilgrims went for prayers and accommodation on their way to crusades.
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Moreover, both artworks involved use of stone materials for building. Some of the features included in both styles are: vaults, apse, niches, ambulatory and radiating chapels. The Romanesque and Gothic styles differ in a variety of features. The Romanesque type of building was mainly used for protective purposes while the Gothic cathedrals were used for aesthetic purposes due to its ornate and delicate decorations.
The difference in the two artworks is shown in table 1. The Romanesque and Gothic architectures both started in France with the former preceding the latter in the 11 th and 12 th centuries.
The artworks have different characteristics but the Gothic style borrowed most of its features from the Romanesque style and introduced expansions. Both styles symbolize the civilization of the middle age medieval age and provided a sense of divinity and a way of reaching to God and were primarily used for religious purposes. Sernin cathedral and Notre Dame Cathedrals have been used as illustrations for the artworks. The two buildings share some similarities and differences. The similarities include the function of the buildings and some of their features.
The major differences are the kind of arches used, the thickness of the walls and the flying buttresses.
Effective steps to write the best paper
The Exam Hall, once Theatre, on the campus of Trinity College Dublin can be viewed as a neo-classical building, built during the Georgian era. Neo-classical architecture is the revival of Greek and Roman classicism that took place in the eighteenth and nineteenth centuries. This was a very significant period for Greek art. Before this time, art lacked dimension and intensity, but the onset of the classical period brought with it influential architecture, vase paintings and sculptures, giving life to its subjects. Many modern day artists draw their creative.
Three Architecture Styles Essay - Words | Bartleby
Ancient Egyptian Greek and Roman Stele Just as we use tombstones to mark graves and commemorate our dead, so too did ancient civilizations. One way to do so in the ancient world was through the use of steles. A stele is a stone slab, usually decorated in relief and inscribed, that honored the death of a person.
Three of the ancient cultures that had implemented the use of the stele were the Egyptians, Greeks, and Romans.
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- On Architecture.
In comparing an example from each civilization, it is possible to see. When comparing Rome and Greece side by side, the two could easily be described as two sides of the same coin. Each heavily influenced the other, cultures mingled and ideas were shared.
Greece and Rome in a sense were sister, but not twins. Sitting on the craggy Balkan Peninsula is a collection of powerful city-states known as Greece. Often credited as the birthplace of western culture, Greek culture shaped the western world into what it is today. Western philosophy, literature, mathematics, history.
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