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Author: Jacqueline Briggs Martin
Narrator: Jennifer Ikeda
Unabridged: 14 min
Format: Digital Audiobook
Publisher: Recorded Books
Published: 03/08/2013
Genre: Children & Young Adults Fiction - Nature & The Natural World - Environment
Ages: 4 - UP
Jacqueline Briggs Martin has received a Caldecott Medal, ALA Notable honors, and Bulletin Blue Ribbons for her endearing children's books. Isabel and the Pig go with Grandfather when he is using his gift to find water. But one day, Grandfather believes he's lost his gift. When the Pig goes missing, Isabel is afraid he will never return. Without Grandfather's gift for finding what cannot be seen, how will they ever get the Pig back? "This poignant story of the magical gift a girl shares with her grandfather is a gem." -Kirkus Reviews
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Museum and Gallery Exhibits • Weekly Events • Submit an Event • Calendar Links
Coronavirus Alert: Due to concerns about the novel coronavirus (COVID-19) events may be cancelled or postponed on short notice. REM is not always notified of such changes. To confirm whether a listed event will proceed as scheduled, contact the event's organizer.
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Roxane Gay: Presence of the Past Keynote Speaker
April 23, 2019, 7:00 PMFree
The Center for the Arts and Humanities is delighted to announce that Roxane Gay will be the keynote speaker for this year's humanities theme, Presence of the Past. Roxane's writing appears in Best American Mystery Stories 2014, Best American Short Stories 2012, Best Sex Writing 2012, A Public Space, McSweeney's, Tin House, Oxford American, American Short Fiction, Virginia Quarterly Review, and many others. She is a contributing opinion writer for the New York Times. She is the author of the books Ayiti, An Untamed State, the New York Times bestselling Bad Feminist, the nationally bestselling Difficult Women, and the New York Times bestselling Hunger. She is also the author of World of Wakanda for Marvel. She has several books forthcoming and is also at work on television and film projects.
Admission is free, but tickets are required. Tickets will be available Monday, April 22, beginning at 9 a.m. and continuing until 3 p.m. or until tickets are gone. Members of the public can pick up tickets on campus in Pulver Pavilion (in Cotter Union). Limit of two tickets per person, please.
This talk will be live streamed on campus with overflow seating in Room 100 in the Lovejoy Building.


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Capri Suites Anaheim Guest Reviews
Write a review
|3.4 miles from Anaheim centre
Write a review
Constantin Wed, 8 July 2020
Paula Tue, 7 July 2020
Dan Sun, 5 July 2020
Very good
Liked: The property was in a good location. The room was clean, but the only inconvenience was the bed. It was a bit noisy. Besides that, I am thankful to stay there.
Douglas Wed, 1 July 2020
Liked: Nothing [email protected]$$
Disliked: No TV in the second room. No room service. No shuttle service. Staff very unhappy and bossy. That's It.....enough right???
Dagoberto Tue, 30 June 2020
I had an okay day.
Liked: Location was really good.
Disliked: There wasn't a working elevators.
Lori Thu, 25 June 2020
Dulce Tue, 16 June 2020
Glenda Sat, 6 June 2020
Liked: Pictures on the web is not wat the rooms look like
Disliked: Pictures on the web is not wat the rooms look like
Jessica Wed, 3 June 2020
Liked: Nothing
Disliked: Everything it?s was dirty toilet didn?t work the ac didn?t work the fridge raider didn?t work staff was horrible wouldn?t recommend to no one
Tyia Sat, 30 May 2020
Hate it here
Liked: Nothing
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text: LTBP #246 – Cath Baxter: How to Use Your Voice to Influence Your Clients and Prospects LTBP #245 – Will Holmes & Laura Dubler: Lessons Learned From Reopening a Gym After Lockdown LTBP #244 – Molly Galbraith: Why Success Takes Time, Deep Market Research and Coaching Women LTBP #243 – Nick Winkelman: Creating Cues, Coaching The Push-Up and Collaborating With Your Clients LTBP #242 – Danny Lennon: What is Health and Should You Start a Podcast? LTBP #241 – Brett Bartholomew: Burnout, Communication and Buy-In LTBP #240 – How To Decide Whether You Should PT Your Clients Outdoors LTBP #239: Nicola Hobbs – Recovering From An Eating Disorder And The Writing Process LTBP #238 – Jonny Stephens: Socially Social Distancing LTBP #237 – Phil Learney: Stories And Lessons From a Veteran Personal Trainer LTBP #236 – Greg Mikolap, Mike Waywell, Will Holmes & Chris Burgess: What Comes Next for Personal Training Facilities? LTBP #235 – Larry Gold: Effective Leadership During Challenging Times 123›»


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Recent automotive trends, reviews, test drives and the latest news from the world of cars
Audi sales leads among luxury brands in 2014
The Audi is a luxury brand with more cars sold in the first two months of 2014. According to an article published by Bloomberg, here were 242,400 vehicles sold worldwide during this period.
Fiat Linea 2015 shows pictureы
Fiat showed on Tuesday (25) images of the model 2015 Linea. According to the statement issued by the automaker, the new sedan will arrive at dealerships in April and Brazil have some aesthetic changes.
New Audi A5 is 90 kg lighter than the current
The Audi A5 will hit the market in 2016 with several modifications. Chief among these is the reduction in weight of the model, now have more aluminum parts, and therefore will be 90 kg lighter.
Chevrolet conducts recall of Agile and Classic models
General Motors of Brazil announced on the morning of Thursday, 6, a statement calling the owners of the models and Chevrolet Agile Chevrolet Classic, manufactured between October 11, 2013 and November 15, 2013, to recall.


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By (AmmoLand.com)
Multiple major US cities were left burning after so-called "protesters" took advantage of the death of George Floyd at the hands of one rogue cop, to destroy, steal and burn private and public property.
Instead of peaceful protest calling for change, we had organized agitators, teenagers, and criminals take advantage of a heartbreakingly tragic situation to rob, loot, and destroy, then burn post offices, banks, retail stores, fast-food restaurants, and liquor stores.
Lost in all of this was any mention of George Floyd, but we heard plenty of incoherent foul mouth laced rants against President Donald Trump as Secret Service Agents were hit in the head with bricks as they pushed back crowds in front of the White House.
None of this had anything to do with the death of Mr. Floyd as the cop filmed killing George has already been arrested and charged with murder in record time. And the FBI, DOJ, state and local authorities are all investigating the filmed death.
A Storm is Here
Each of the cities engulfed in flames last night are Democratically controlled strongholds with weak Mayors and Governors. They all have allowed this chaos and destruction to go on without enforcing the law or sending in the police or national guard to stop this madness, all in the name of letting "protesters" blow off steam. When in our lifetimes have we ever seen an American police station abandoned and allowed to be looted and burned. I hope no one was locked in the cells!
Where is the national leadership of the Democratic party? Not a single one of them has come out in condemnation of the law-breaking looters? On the Republican side, we have only seen a few including Texas senator Ted Cruz call them out for what they are, criminals thugs!
We saw the deep states' attempt at a soft coup in the case of Michael Flynn against Donald Trump. It seems that the peaceful transition of power has disappeared from our nation, and we are seeing a trial run of their next attempt at a hard, violent coup to change America into the United Communist States of America forcibly.
We now see the future response we can expect from Democrats and their thug allies when they lose the election in November…again. This time it appears that rather than crying and screeching, they are intent on destroying and burning America.
The past few nights should be a wake-up call for anybody who believes in law and order and the decency towards their fellow Americans. We have heard this time and again that "this election is the most important one" well, it appears now we're at another election battle for the soul of our country, so be prepared to vote.


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"Nissan has been providing information to the Japanese public prosecutors office and has been fully cooperating with their investigation. We will continue to do so."
Recent Posts
- 'Work together around an open solution': As Rubicon and Telaria rebrand as Magnite, the SSP sets out to rival the walled gardens
- Sex toy sales are up and publishers are seeing an opportunity to grasp
- 'Are you going to put people over profit?': As Facebook boycott continues, DTCs still running ads on the platform in a tricky spot
- WTF is California's new, and potentially stronger, privacy law?
- Deep Dive: How publishers must adapt to the new normal


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Tag: Towerside
MWMO Winter Newsletter – Project Updates, News, Events and More
New park taking shape in Prospect Park
Minnesota Daily - Dec. 4, 2019
[…] The group also collaborated with the Mississippi Watershed Management Organization. MWMO constructed a "stormwater park" on an adjacent plot. The park's infrastructure collects and filters water into an underground storage tank. The water will then be pumped into the new park's shade structure an ultraviolet light will kill any remaining bacteria, said Marcy Bean, […]


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Annual Meeting
This year, the 2020 PEC Annual Meeting will be closed to member and public attendance to meet safety and health concerns. The annual meeting is June 19, at 9 a.m. at PEC's headquarters in Johnson City, and will be held immediately before the June board meeting. It will be recorded, and the video will be posted online once available.
Winners of PEC's 2020 Board of Directors Election results are posted here. Early voting incentive prize winners will be individually notified and are posted below.
Members may provide comments by completing this form by 8 a.m. on June 19. All comments will be shared with PEC Board Directors and maybe included in the meeting minutes. As always, members may access board meeting dates, agendas, and supporting materials online at https://pec.legistar.com/.
Early voting incentive prize winners
- Lauren Grossman, Cedar Park
- Bivian W Cox, Cedar Park
- J L Bergeron, Cedar Park
- Kenneth Smith, Austin
- Cornelius Duarte, Leander
- Clarence C Acacio, Austin
- John M Grogan, Dripping Springs
- Richard Biedler, Austin
- Haiyan Liu, Cedar Park
- Robert H Judd, Drippings Springs
- Ian Cohen, Austin
- Andrew Miller, Wimberley
- Shannon Eckols, Driftwood
- James Wright, Austin
- Burnice Cowan, Kyle
- Travis Turner, Cedar Park
- Richard Stark, Dripping Springs
- Leah Tremblay, Leander
- Matthew D Evans, Leander
- Sara Hamsa, Cedar Park
- Lisa Wenske, Austin
- David Williams, San Jose, CA
- Derrick Steele, Austin
- Gary Nesmith, Wimberley
- Chris Millette, Austin
- Ernest Lewis, Wimberley
- Maricela Esmeralda, Austin
- Luis M Zervigon, Cedar Park
- Scott Bonniwell, Driftwood
- Matthew Walker, Leander
- Maylene Garcia, Cedar Park
- Cynthia King, Leander


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Type 1 diabetes is increasing in incidence in many parts of the world and it might be imagined that the pathological processes that underlie disease progression are firmly understood. However, this is not the case; rather, our collective understanding is still surprisingly rudimentary. There are various reasons for this but one of the most important is that the target organ (the pancreas) has been examined at, or soon after, diagnosis in only a small number of cases worldwide over the past half a century. This review provides a summary of some of the insights gained from these studies and highlights areas of ongoing uncertainty. In particular, it considers the process of insulitis (a form of islet inflammation that occurs characteristically in type 1 diabetes) and discusses the factors that may influence the access of immune cells to the beta cells. Attention is also drawn to recent evidence implying that two distinct profiles of insulitis exist, which occur differentially in people who develop type 1 diabetes at increasing ages. Emphasis is also placed on the emerging (and somewhat surprising) consensus that the extent of beta cell loss is variable among people with type 1 diabetes and that many (especially those who are older at onset) retain significant numbers of insulin-producing cells long after diagnosis. We conclude by emphasising the importance of renewed efforts to study the human pancreas at disease onset and consider how the current insights may inform the design of future strategies to slow or halt the rate of beta cell loss.
Historical perspectives
The concept that type 1 diabetes represents a specific disease with a unique aetiology only gained acceptance in the mid-1970s [1] although earlier pioneering studies (mainly by Willy Gepts in the 1960s [2]) had hinted at this conclusion by revealing some of the characteristic pancreatic pathology now known to define it. Progress has remained sluggish, however; largely because a meticulous examination of the target organ is not easily achieved in living individuals. Efforts are underway to improve non-invasive imaging [3] but, in humans, the pancreas remains largely inaccessible and surgical interventions still carry a serious risk. Useful rodent models have been developed to assist in defining the aetiology of type 1 diabetes [4,5,6] but there are fundamental differences between the rodent and human pancreas with respect to islet architecture [7], innervation [8, 9] and vasculature [8,9,10], which require caution to be exercised.
Looking back over the last 50 years, it is sobering to realise that fewer than 600 human pancreatic samples in total have been studied from people with type 1 diabetes or are available in pancreatic biobanks (Fig. 1; Table 1). Moreover, only a small subset of these come from young people with recent-onset disease. The largest collections are held in the Exeter Archival Diabetes Biobank (EADB) and the Network for Pancreatic Organ Donors with Diabetes (nPOD) [11]. The EADB is an archival collection comprised of predominantly post-mortem pancreas samples collected from young people (<20 years old) with recent-onset (<2 years) disease who died between 1935 and the mid-1990s [12]. Importantly, it contains the world's largest collection of pancreas tissue from individuals diagnosed with diabetes under the age of 10 years (a comparison of the two largest collections is shown in Fig. 2; Table 2). However, most specimens were obtained post-mortem and the tissue is of variable quality such that its suitability for certain applications (e.g. RNA sequencing) is limited. By contrast, nPOD tissues are harvested and processed according to optimised standard operating procedures and samples are available for multiple applications [11, 13, 14]. Nevertheless, most nPOD pancreases come from older-onset donors with longer disease duration (Fig. 2; Table 2) and only a single organ is currently available from a donor under the age of 7 years with a short duration (<2 years) of disease. Newer initiatives, including the European INNODIA consortium and a Medical Research Council (MRC)-funded pancreas collection (the Quality in Organ Donation [QUOD] Biobank; coordinated from the University of Newcastle, UK) promise to deliver high-quality samples in the future. Further study of pancreas biobanks remains paramount for an improved understanding of diabetes [15].
Islet structure and composition
In humans, islets are widely dispersed across the pancreas, although they may be present at higher density in the head and body of the organ than in the tail [16]. Each islet has a multicellular structure and, in rodent species, the beta cells are localised at the centre with the remaining endocrine cell types arranged in a peripheral 'mantle'. In human islets, the beta and non-beta endocrine cells occur in a less structured conformation, particularly in larger islets [7, 16] (Fig. 3). Moreover, the proportions of the various endocrine cells are different between species, with a smaller overall percentage of beta cells (50–60%) in humans than in rodents [16, 17].
An important advance arising from studies of the human pancreas in type 1 diabetes has been the description of insulitis, a process of immune cell infiltration into islets [18] (Fig. 4). This is also seen in animal models but insulitis is found at a lower frequency across the islet population in humans than in rodents, and the proportion of the various individual immune-cell subtypes differ between species (e.g. CD8+ T cells dominate human insulitis, whereas CD4+ cells are predominant in NOD mice). One note of caution, however, is that some evidence implies that the period spent in intensive care prior to organ recovery can influence the extent of immune-cell infiltration into the human pancreas [18].
Insulitis occurs mainly within the residual insulin-containing islets of people with recent-onset type 1 diabetes and many fewer insulin-deficient islets are inflamed [12, 19,20,21]. This implies that immune cells are recruited and retained primarily in response to factors emanating from their target beta cells, although the proportion of islets with inflammation varies, not simply in response to beta cell numbers, but also according to the age at disease onset. For example, among individuals diagnosed aged 13 years or older, the proportion of residual insulin-containing islets with insulitis is around 25%, whereas it is much higher (~80%) in those diagnosed in the very early years of life (<7 years of age) [22]. These statistics suggest that young children may have a more aggressive form of the disease. A further implication is that, among older individuals, functional insulin deficiency can occur despite the retention of a significant reserve of the hormone. This points not only to beta cell loss as a cause of type 1 diabetes, but also suggests an insulin-secretory dysfunction among the residual, non-inflamed islets in some individuals. These conclusions are supported by in vitro studies showing that the immediate post-isolation deficit in glucose-induced insulin secretion in the islets of people with type 1 diabetes may improve with time in culture [23].
The occurrence of insulitis is not restricted solely to the period immediately after disease onset but it can also be found in the insulin-containing islets of individuals with long-duration disease [21]. By contrast, it is less clear how long before diagnosis insulitis occurs in people who are progressing to disease. This is much more difficult to evaluate, of course, because prediction of disease onset is still an imperfect art. Nevertheless, it has proved so hard to uncover firm evidence of insulitis in individuals prior to disease onset that In't Veld has defined the process as an 'elusive lesion' [21, 24,25,26].
Progression of insulitis
The relative difficulty in identifying insulitis in the human pancreas has led to the publication of an international consensus statement by which insulitis can be defined [27]. This represents a welcome advance since varying definitions have appeared in the literature over time [11, 19, 25, 28,29,30,31]. The consensus definition notes that 'the lesion should be established in a minimum of three islets, with a threshold level of ≥15 CD45+ cells/islet before the diagnosis can be made' [27, 32]. The utility of this statement has been challenged [33], but it remains an internationally accepted working definition [32].
Although the precise composition of the immune infiltrate is variable between islets and among individuals, important categories of insulitis have now been defined. In particular, in humans, CD8+ T cells are predominant, whereas CD4+ cells are often represented only as a minority population [19, 21, 34, 35]. In addition, the proportion of CD20+ cells (B cells) is variable [34,35,36] since, in very young children (≤7 years of age) these are present in relative abundance in inflamed islets, whereas their proportion is much lower in those who are older at diagnosis [34, 35]. The consequences of this difference (and the factors that underlie it) remain uncertain, but such variability must be considered when designing immunotherapeutic trials intended to reduce the rate of beta cell demise. In addition to lymphocytes, other immune-cell subtypes, including neutrophils [37], mast cells [38] and natural killer cells [39], have been reported to infiltrate the pancreas in, at least, some individuals with type 1 diabetes.
Work in the NOD mouse suggests the existence of sequential 'stages' of insulitis [40]; among these is a feature known as 'peri-insulitis' in which islets are surrounded by immune cells but not infiltrated by them. This is followed by more complete infiltration, where islets are invaded and the killing of beta cells occurs at high frequency. Equivalent stages are not seen in humans and invasive insulitis is detected only rarely. This suggests either that, in humans, the killing of beta cells is mediated by the very small number of immune (presumably CD8+) cells that penetrate into the endocrine cell milieu or, alternatively, that killing does not require direct contact between immune and beta cells. A third possibility also exists, in which the immune cells play (at best) only a minor role in beta cell death. In this context, recent evidence implies that many of the CD8+ cells present in insulitic lesions are resident memory cells, which lack a proinflammatory gene expression signature [41]. Nevertheless, it is also clear that some of the influent CD8+ T cells are reactive against islet antigens, suggesting an aggressive intent [42,43,44].
The histological feature referred to above termed 'peri-insulitis' mirrors most closely the arrangement of immune cells found in many inflamed islets in human type 1 diabetes. However, unlike the situation in NOD mice, where islets are surrounded by successive banks of lymphocytes, the influent immune cells are fewer in number in human islets and tend to adorn one of the poles [27, 45] (Fig. 4). This distribution suggests that immune cells are initially attracted to the islet environment but, on arrival, they encounter a barrier to entry. This is probably the 'peri-islet membrane', a structure that may require considerable re-modelling in order to permit immune cell entry.
Islet extracellular matrix
The peri-islet membrane forms part of a complex extracellular matrix that serves both to contain the islet cells and to restrict the access of influent immune cells (reviewed in [46]). The structure is sufficiently loose that soluble molecules, including islet hormones, chemokines and cytokines, can penetrate, but it is more restrictive to the passage of cells. It takes the form of a basement membrane consisting of a matrix of collagen (mainly type IV) and a multitude of associated (glyco)proteins, including perlecan and various laminins. The composition of this membrane is very similar in mouse and human islets, although there are important differences in laminin composition [46, 47]. Beneath the basement membrane is an interstitial matrix made up of other collagen isoforms (mostly types I, III and VI) plus fibronectin and large glycoproteins belonging to the fibrillin and matrilin families. Together these represent a formidable barrier to immune cells.
In order to gain entry to the islet milieu, the basement membrane components must be degraded and, in humans, this occurs in a targeted manner close to the point of immune attack, rather than as a more generalised disintegration of the basement membrane around the whole islet [47]. Interestingly, recent modelling of the process using mathematical simulations has suggested that permeation of the islet basement membrane may be the rate-limiting step in beta cell death in type 1 diabetes [48].
Korpos and colleagues have attempted to define the origin and identity of the enzymes responsible for mediating the breakdown of the islet basement membrane during insulitis and, based on both inhibitor and mRNA expression studies using laser capture microdissected islets, they have proposed that cathepsins are prime candidates [47]. High-resolution analysis has led to the conclusion that macrophages and dendritic cells are the likely source of these enzymes and such cells are present in modest numbers during the autoimmune attack. Whether the accompanying lymphocytes play a direct role by also secreting additional proteases, remains to be established.
Islet chemokine expression
A key question that arises when considering the mechanisms by which immune cells might reach the islet, is the nature of the chemoattractant. It has been widely assumed that islets are induced to secrete chemokines during the initiation phase of beta cell destruction and that relevant immune cells then migrate to the source of these molecules. In support of this, several chemokines have been detected in inflamed islets, including, most frequently (but not exclusively [49]), the (C-X-C motif) ligand (CXCL)10 [50, 51]. This interacts with its cognate receptor, CXCR3, which has been detected on a subset of CD3+ cells present in immune infiltrates, including on a proinsulin-directed, autoreactive clone isolated from an individual with type 1 diabetes [50]. It is also known that beta cells can directly produce certain cytokines, including IL-1β [52], which might play a role in mediating their demise.
Islet HLA class I hyperexpression
A characteristic feature seen in the majority of insulin-containing islets in individuals with type 1 diabetes is hyperexpression of HLA class I [53, 54]. This was first described in early studies by Bottazzo's group [55] and Foulis et al [53], but has subsequently been confirmed by others [54, 56]. Importantly, HLA class I hyperexpression is not solely restricted to the beta cells in inflamed islets since it occurs in all islet endocrine cells [54], suggesting that the cells are responding to a locally produced agent that is present uniquely in type 1 diabetes. The response is also independent of the simultaneous presence of infiltrating immune cells since it occurs in islets that are inflamed and those that are not [53]. Importantly, hyperexpression of HLA class I does not persist in islets that are deficient in beta cells [45, 53, 54].
Foulis and colleagues were able to correlate HLA class I hyperexpression with the presence of IFN-α in islets studied in situ [57] and subsequent in vitro experiments have confirmed that exposure of isolated human islets to IFN-α causes HLA class I hyperexpression [58, 59]. Set against this, gene expression studies performed on laser captured, microdissected islets from pancreas biopsies recovered from living individuals soon after the diagnosis of type 1 diabetes have suggested that IFN-α levels are not elevated in these samples [51]. Thus, a dilemma remains.
Beta cell loss in type 1 diabetes
By convention, it has been tacitly assumed that the demise of beta cells consequent to insulitis is mediated by enhanced apoptosis since exposure of human islets (or clonal beta cells) to proinflammatory cytokines, in vitro, leads to apoptosis [60]. Despite this, only modest increases in beta cell apoptosis have been detected in human type 1 diabetes [28] and this may reflect the rapid clearance of apoptotic cells by resident macrophages, which are known to patrol the islet milieu [19]. However, this explanation may also obscure a more fundamental possibility that beta cell apoptosis occurs much less frequently than is supposed. This concept is gaining acceptance in type 2 diabetes, in which beta cell depletion is increasingly attributed to a process of either de- or trans-differentiation, whereby the beta cell phenotype is lost but the cells themselves remain [61]. Levine's group have provided evidence for the emergence of larger-than-expected numbers of delta cells in human islets during long term type 1 diabetes and have proposed that these may arise by a process of beta cell trans-differentiation [62]. This idea requires further verification but implies that beta cells may not always die in large numbers, after all.
A further feature revealed in recent studies of whole pancreas organs recovered from donors with type 1 diabetes is that the depletion of the islet cells correlates with a more generalised deficit in total pancreatic mass [63]. This was first mooted in the study by Foulis and Stewart [20] and more recent examination of transplant-grade samples from within the nPOD collection has revealed an ~40% reduction in relative pancreas weight in type 1 diabetes vs age matched controls [64]. Thus, the traditional view that the pathological effects associated with type 1 diabetes are restricted solely to the endocrine compartment of the tissue may require revision and increasing evidence suggests that imbalances in immune-cell infiltration also extend more widely across the gland [37, 64].
Our understanding of the aetiopathology of type 1 diabetes has advanced greatly since the pioneering studies by Gepts [2], mainly thanks to the opportunity to study additional rare and precious pancreas samples recovered from individuals with the disease. Nevertheless, the task is not complete and the more we look, the more the accepted wisdom is challenged. It is critical, therefore, that such work continues since only then will new opportunities for therapy and disease prevention emerge.
Data availability
The datasets generated and/or analysed during the current study are available from the corresponding author on reasonable request.
(C-X-C motif) ligand
Exeter Archival Diabetes Biobank
Medical Research Council
- nPOD:
Network for Pancreatic Organ Donors with Diabetes
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We are grateful for the contributions of many colleagues who have helped to identify the type 1 diabetes cases held within biobanks and/or reported in the literature. In particular, we are indebted to P. In't Veld (Vrije Universiteit Brussel [VUB], Brussels); A. Foulis (GG&C Pathology Department, University of Glasgow, UK); M. Yang, M. Beery and A. Pugliese (nPOD, Miami & Gainesville, Florida, USA); J. Shaw (Institute of Cellular Medicine, University of Newcastle, UK); F. Dotta (Department of Medicine, Surgery and Neurosciences, University of Siena, Italy); and O. Skog (Department of Immunology, Genetics and Pathology, Uppsala University, Sweden). In addition, we would like to acknowledge the valuable work of other colleagues which has not been cited in this review due to space restrictions.
We are grateful for collaborative discussions with the Network for Pancreatic Organ donors with Diabetes (nPOD; RRID:SCR_014641), a collaborative type 1 diabetes research project sponsored by JDRF (nPOD: 5-SRA-2018-557-Q-R) and The Leona M. & Harry B. Helmsley Charitable Trust (Grant no. 2018PG-T1D053). Organ procurement organisations (OPO) partnering with nPOD to provide research resources are listed at www.jdrfnpod.org//for-partners/npod-partners/.
We are pleased to acknowledge financial support via a JDRF Career Development Award (5-CDA-2014-221-A-N) to SJR, an MRC Project Grant (MR/P010695/1) to SJR and NGM, and project grants from Diabetes UK (15/0005156 & 16/0005480) to NGM and SJR.
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Morgan, N.G., Richardson, S.J. Fifty years of pancreatic islet pathology in human type 1 diabetes: insights gained and progress made. Diabetologia 61, 2499–2506 (2018). https://doi.org/10.1007/s00125-018-4731-y
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- Beta cell
- Chemokine
- Cytokine
- HLA class I
- Insulin
- Insulitis
- Islets of Langerhans
- Review


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Imitation Crab Wheels Recipe 2
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- 2 teaspoons oregano, dried
- 4 English muffins, seperated into 8 rounds
- 1 can (8 ounce) black olives, sliced or broken up (more or less to taste)
- parmesan cheese
DirectionsSaute the peppers and onions in pan until soft.
Drain the peppers and onions on a paper towel and let cool.
In a bowl, mix imitation crab, mayonnaise, cooled peppers and onions, cheese, olives, and oregano until well blended.
Spread a few spoonfuls on rough side of english muffin halves.
Sprinkle with parmesan cheese.
Broil for 4-5 minutes or until cheese melts and mixture is bubbly.


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Lord Marksman and Vanadis Vol. 8
- £7.49
- £7.49
Publisher Description
After their clash with the armies of Muozinel, Tigre and his companions stand victorious. Yet on the very same night a new threat strikes from the shadows. An inhuman assassin seeks Tigre's head, and he fights with an unnatural strength. Worse yet, Duke Thenardier seals a pact with the same shadowy organization, seeking enough power to vanquish Tigre's Silver Meteor force once and for all!


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What does faith have to do with work? How can we leverage faith to allow professionals to reach peak performance without being stressed, drained, or overwhelmed? In this interview, Mohammed Faris, CEO of the ProductiveMuslim Company shares his experience delivering corporate workshops on Barakah Culture vs. Hustle Culture. You'll hear first-hand stories of how hisRead article
How Salah Will Guide Your 'New Normal'
Every major consulting company and expert is trying to figure out what the 'new normal' would be post-COVID19. In these moments of doubt of what the future holds, more than ever, we need to hold on to the certainties of life. One of them being Salah. In this article, I'll explore how Salah – theRead article
Surat Al-Mulk: A Spiritual Antidote to the Global Pandemic
In this global pandemic, it is understandable that we have fears and anxieties. Reflecting on the current situation and the way out of this global crisis can make us feel overwhelmed. But is there a way to find peace, perspective and balance in approaching this situation? This is what Surat Al Mulk ('The Sovereignty' ChapterRead article
What Islam Offers to Modern Self-Help: An Islamic Paradigm of Psychology
Islam offers not only a theological framework within which we can position ourselves in relation to God, but it also offers a holistic map for how to navigate the human experience on a path of development of the self, or soul. While we may understand and believe that the Qur'an and Sunnah provide all ofRead article
Barakah Culture Manifesto in 100 Words
The following manifesto was written in the city of Barakah, Al-Madinah Al-Munawarah (The illuminated City), the city of Prophet Muhammad in November 2019. Click below to get the above Manifesto in high-quality 18″ x 24″ poster delivered to your home. Backstory: Blessings upon Blessings When I visited the blessed city of Prophet Muhammad in NovemberRead article
How To Set Goals Like a Gardener?
As human beings, we're driven towards setting goals and achieving them. Unlike animals, we are not content to simply sit, eat, reproduce, and sleep; we have an innate 'meaning-seeking' side to us that's part of our fitrah (natural disposition) which ultimately is geared towards finding and fulfilling our ultimate purpose and that is to beRead article


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Welcome to leisure centre online bookings
Group Fitness, racket sports and gym
Currently whilst Fitness+ memberships are suspended, all activities must be booked online and paid for at the time of booking.
To book a group fitness course choose the 'courses' option on the menu to the left. Our outdoor group fitness sessions are currently being run as courses, so are booked in 6 week blocks.
To book a tennis court choose the 'activities' option on the menu to the left.
Golf memberships have been reinstated, so if you are a member of Normanby Hall Golf Course you will need to register on the site before booking a tee time.
You can book a round of golf without being a member. To book a tee time choose the 'activities' option on the menu to the left of the screen.
For more information please visit our website or our frequently asked questions
If you experience any difficulties please contact email@example.com


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Dear folks, help us raise funding for our community directly. And in the process you'll have a chance to win some terrific tools donated by our sponsors! Read More...
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Carlton Palmer has told talkSPORT Sam Allardyce is the man to save West Brom – but doesn't believe he'll take the job.
The former Bolton and Blackburn boss has indicated he won't apply for the vacant Hawthorns post, and Palmer doesn't think Big Sam would accept the current structure at the club.
Palmer told the Alan Brazil Sports Breakfast: "If you're going to sack someone, and you want to stay in the Premier League, there's only man out there and that's Sam Allardyce.
"He went into Blackburn when they were dead and buried [and kept them up]. But Sam's not going to take the West Brom job.
"He won't work under that regime with a technical director who seems to signal the players they want to come in, and he's got no money. And the transfer window is closed so they can only bring frees in."
Palmer feels Albion acted hastily by sacking Roberto di Matteo, and wonders what more they could have expected of him.
He added: "It was a really harsh sacking and I think it's the wrong decision.
"Di Matteo did a fantastic job. He got promoted, but didn't have the sort of money other clubs had to spend in the transfer market, so from the start of the season it's all about survival.
"I did think they'd go down, because any club that ships the amount of goals they do is going to be in serious trouble.
"It's always going to be difficult, but unless you're making huge investment there's the likelihood you're going to go down."


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Since its imperative that single-hood is celebrated just as loudly and proudly as any romance would
Actor, in a statement, thanks his fans and requests privacy.
Brenda Osborne has witnessed the two World Wars, the crowning of three monarchs and England's 1966 FIFA World Cup win
Actor spoke about her relationship status at the Jagran Film Festival held in New Delhi on Friday
Everyone asks me the same question, every now and then: 'When are you getting married?'
For starters, you'll be richer
'Pillowtalk' is set to release on January 29
Take the quiz and find out!
Holder hails Gabriel's 'massive heart' as Windies beat England
Two-day Pakistan intra-squad practice match ends in a draw
Blackwood stars as West Indies down England in first Test
Pakistan has decided it will not evacuate its citizens from China to counter the threat of the fast-spreading corona virus. Do you agree with the decision?
Polls are non-scientific, reflect only the online audience and can be manipulated.
One can only pray rule of law is enforced rather than another cycle of political point-scoring
Cyber harassment also has severe psychological repercussions
Billion-tree programme
The recent downpour in Karachi has caused much havoc for citizens.
Those who consider taking online classes a piece of cake must do a little research
It has been four years since the death of Abdul Sattar Edhi
Letters will be edited for policy, content and clarity. All letters must have the writer's name and address. You may send your letters to: [email protected]
خیبرپختونخوا میں 47 ارب روپے کے قرضوں سے ترقیاتی منصوبے مکمل کیے جائیں گے
اجمل وزیر آڈیو اسکینڈل: کیا سازش پی ٹی آئی کے اندر سے ہوئی؟
پاکستان کا افغانستان کی بھارت برآمدات کے لئے واہگہ بارڈر کھولنے کا اعلان
The writer is an Egyptian researcher with a special interest in Middle Eastern Issues
The writer is an economics and political science graduate, and founder of the educational initiative Averroes
The writer is a psychiatrist. He is a fellow at the department of anesthesiology and critical care management at Johns Hopkins Hospital, Baltimore, Maryland, United States.
This material may not be published, broadcast, rewritten,
redistributed or derived from. Unless otherwise stated, all content is
copyrighted © 2020 The Express Tribune.


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Free Download
visionapp Remote Desktop 2012
A way to uninstall visionapp Remote Desktop 2012 from your PC
This page contains detailed information on how to remove visionapp Remote Desktop 2012 for Windows. It was developed for Windows by
visionapp AG
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for more info on visionapp AG. You can read more about on visionapp Remote Desktop 2012 at
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putty.exe (577.50 KB)
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Windows 8.1 (6.3)
Windows 7 (6.1)
Software Application
This page is not a recommendation to uninstall visionapp Remote Desktop 2012 by visionapp AG from your computer, we are not saying that visionapp Remote Desktop 2012 by visionapp AG is not a good application. This page simply contains detailed info on how to uninstall visionapp Remote Desktop 2012 in case you want to. The information above contains registry and disk entries that Advanced Uninstaller PRO discovered and classified as "leftovers" on other users' computers.
2016-09-10 / Written by Daniel Statescu for
Advanced Uninstaller PRO
follow @DanielStatescu
Last update on:
2016-09-10 18:02:32.807


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Danielle Boothe is one of Cayman's best teenage swimmers and that was shown when she swam for Jamaica last week.
Boothe captured six of Jamaica's 20 medals at the Caribbean Islands Swimming Championships in Barbados.
She took home four silver and two bronze to lead Jamaica's successful 12-member team medal tally of four gold, nine silver and seven bronze medals.
Boothe, 18, got her medals in the 200-meter backstroke (2 minutes 27.21 seconds), as well as the 200m and 400m individual medley in 2:26:88 and 5:15:88 minutes, respectively. She then clocked 31.48 seconds for bronze in the 50m backstroke, followed by 1:08:54 and 1:05:59 minutes for bronze in the 100m backstroke and butterfly events.
Boothe's outstanding performances saw her winning the high point trophy for her age group after she tallied 48 points and made 'B' cut times in more than four events, which qualified her for the 2015 Pan Am Games. She now wants to reach 'A' standard times.
If you value our service, if you have turned to us in the past few days or weeks for verified, factual updates, if you have watched our live streaming of press conferences or sent an article to a friend... please consider a donation. Quality local journalism was at risk before the coronavirus crisis. It is now deeply threatened. Even a small amount can go a long way to sustaining our mission of informing the public. We need our readers' financial support now more than ever.


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Sib u bbukkja postijiet uniċi fejn toqgħod fuq Airbnb
Il-klijenti jaqblu: dal-postijiet fejn toqgħod huma mfaħħra ħafna għall-post, l-indafa u għal kwalitajiet oħra tagħhom.
Beautiful sunset views from this second story Tesuque studio (separated from main house). Situated on 5 gorgeous acres of land. Short drive to historic Santa Fe plaza and close to world-class Santa Fe Opera, shopping, restaurants, hiking, and Native American pueblos. Relax in your private space with separate entrance. Fully equipped kitchen, full bath with tub, large windows, and wood laminate floors for ease of use. Outdoor fireplace and patio. Clean, light, and bright. Dog friendly!
In the heart of Santa Fe lies a beautiful home full of character and life. This home can be used for family vacations, quiet getaways or any type of stay. Steps away from the start of the Windsor Trail, this amazing Santa Fe home includes an area for barbecuing, an amazing ridge with a 360° view and a home that will make you feel like you are at a resort. This oasis located in the hills of Santa Fe is everything you are looking for in a vacation getaway.
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This laser cut kit includes the pattern and 4 pre-fused pieces ready to place on your favorite background fabric. We have two submission for Quilter's Trek 2020. One is for Quilts on the Corner in Utah and the other one is for My Quilting Corner in Idaho. The theme is "Blue" and we have chosen 4 different navy blue or true blue fabrics. Each block is cut from different fabric. Each kit will include the Utah or Idaho fabric token while supplies last. **Background, backing and binding NOT included.
2 Reviews
Quilter's Trek Laser kit
Love the fabrics. Niche clean cuts. Arrived quickly and so neatly packaged. Can't wait to use them in my quilt.
Great block
Cute blocks. Easy instructions. Love the kit!!


text:
- RT @ScotGovPlanning: The Minister and Chief Planner have written today to clarify the '28-day rule' for permitted development in relation t… 3 days ago
- RT @Edin_Licensing: We're working with a range of services to create a new streamlined application process for the use of tables and chairs… 4 days ago
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Weekly List Interactive Map
We have written previously about the need to publicise applications and decisions made online, due to Covid -19 restrictions preventing us from using our usual way of advertising. We have already been publishing our weekly lists online here, but we … Continue reading
Posted in News & updates, Systems Tagged applications, City of Edinburgh Council, decisions, gis, interactive, map, planning, weekly list Leave a comment
Maybe a little dull to some, but do not be fooled. Maps can be very interesting. Particularly colourful, interactive and FREE maps. This week, Ritchie Somerville swung by the Urban Room to teach Council planners about maps and freely accessible information – … Continue reading
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Visitors' Book
Postcards of Resht and Enzeli. From the latter part of September 1918 to the middle of November 1918, Cyril Sladden was based in Resht in modern-day Iran and was there at the time of the Turkish Armistice. It is the largest city on Iran's Caspian coast and the capital city of Gilan Province. Nearby is the port of Enzeli (also known as Bandar-e Anzali) and also the village of Pirébazar.
© The Sladden family descendants and by kind permission of the Imperial War Museum (reference 60/98/3)


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Product details
What could be better than endlessly versatile cargo shorts? Slightly stretchy ones made from a supersoft cotton blend, we think. Choose between two lengths, both with turn-ups. And a pocket or two always comes in handy – so we've added them at the side and back.
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Falmouth Linen Shorts - Orange Sunset
These flatteringly smart sailor shorts bring a little nautical chic to your wardrobe. Crafted from 100% linen, the semi-fitted shape is asking to be paired with classic Bretons and breezy linen shirts alike. The standout buttons on either side not ...


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Karl-Anthony Towns dominated at the start and Ricky Rubio took over in the end, adding up to a big win for the Minnesota Timberwolves.
Towns had 34 points and 11 rebounds, while Rubio added 13 points and a season-high 15 assists as the Timberwolves ended a four-game losing streak with a 101-92 victory over the Dallas Mavericks on Monday night.
"The team was struggling lately and everybody had to do a better job in the fourth quarter, and I think we did today," Rubio said. "We've been doing a pretty good job for three quarters all season, but the fourth quarter is just different. It's when you win games."
Photo: AP
Harrison Barnes scored 30 points for the Mavericks and Dirk Nowitzki had 26, including five three-pointers.
"We were never able to control Towns, obviously," Nowitzki said. "He got too deep some; just never really had an answer for him."
Towns scored Minnesota's first seven points and 16 in total in the first seven minutes. He finished with 20 in the period as the Timberwolves took a 33-14 lead after one quarter.
"I guess it was my lucky day," Towns said. "I just found good ways to find ways that they couldn't double-team me in spots where it was very difficult to double-team me."
Rubio scored nine points in the fourth quarter, including consecutive baskets during an 8-0 run that gave the Timberwolves some breathing room after Dallas had whittled a 21-point lead to 81-77.
His three free throws put the Wolves up by 14 with 2 minutes, 8 seconds to play, effectively sealing the game.
Elsewhere, New York point guard Derrick Rose was a mysterious no-show at Madison Square Garden, and that was just one of the Knicks' problems in a 110-96 defeat to the New Orleans Pelicans.
The Knicks started Brandon Jennings at point guard instead of Rose, the team tweeting only a terse announcement that "Derrick Rose is not with the team."
Coach Jeff Hornacek had given no indication of Rose's absence in his pre-game news conference. After the game he tried to deflect questions about the player.
"Right now we don't have enough information to really give you anything," Hornacek said. "So that's just going to have to wait until we hear something from Derrick himself."
Hornacek refused to be drawn on reports that team staff had been unable to contact Rose.
"I'm not going to comment on any of that stuff," he said. "We expect him back, sure. It's just a matter of time."
"We want to respect whatever he's going through, and we're just not going to comment on it," Hornacek said.
Teammate Joakim Noah said he had been in touch with Rose after the game, but he shed no real light on Rose's absence, later reported by ESPN to be due to a family matter.
"I don't really want to talk too much about it, because I don't know what the situation is," Noah said. "I'm just happy that everything is OK with him."
Rose, 28, the 2011 NBA Most Valuable Player with the Chicago Bulls, has been effective in his first season with the Knicks.
He averaged 17.3 points in 33 games, missing a few earlier this season with back spasms.
In Rose's absence, the Knicks lost for the eighth time in nine games.
Star forward Carmelo Anthony was ejected during a third-quarter time-out, drawing two technical fouls for arguing over officiating.
Shortly afterward, Knicks reserve Kyle O'Quinn was ejected for a hard foul that sent Pelicans star Anthony Davis flying into courtside seats along the baseline.
British Prime Minister Boris Johnson on Friday said that he had called in the "third umpire" as he announced that recreational cricket would be allowed to resume next weekend. In a radio interview earlier on Friday, Johnson angered thousands of club cricketers by saying that the amateur game was still not safe to play amid the COVID-19 pandemic because of issues surrounding communal teas and dressing rooms. "It's the teas, it's the changing rooms and so on and so forth. There are other factors involved that generate proximity which you might not get in a game of tennis," he said. Johnson had already
Hong Kong media reported that police briefly detained a man in a Liverpool team jersey who shouted "long live Liverpool" during anti-government protests on Wednesday, over suspicion that he was inciting independence. In-Media reported that the man was across the street from police officers who were conducting stop-and-searches on a group of protesters, when he shouted: "Long live Liverpool." Others reportedly cheered and joined in the chant, before officers detained him. The man told In-Media that police had accused him of inciting Hong Kong independence, which now is a punishable crime. He said that he has been a fan of the English soccer
Raptors guard Fred VanVleet is already in Florida with the rest of his Toronto teammates, and he knows the time to take a stand and counter the NBA plan to restart the season has passed, but his opinion on the matter has not changed. "It sucks," VanVleet said on Monday in a videoconference of his choice to return to the court during the COVID-19 pandemic and Black Lives Matter campaign. "It's terrible timing, but that's been 2020 for us. We all know the right thing to do is to not play, to take a stand. Morally, yes, that makes sense, but
Legendary batsman Everton Weekes, the last of the famed West Indies "Three Ws," died on Wednesday at the age of 95 and was hailed as "a founding father" of the sport in the Caribbean. "Our hearts are heavy as we mourn the loss of an icon. A legend, our hero, Sir Everton Weekes," Cricket West Indies (CWI) wrote on Twitter. "Our condolences go out to his family, friends and many fans around the world. May he rest in peace." Barbadian Weekes was part of a feared post-World War II West Indies team who also featured Clyde Walcott and Frank Worrell. Walcott died in


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|User Name
|Thread Name
|Susan of DT
|Tech: A font for your song book. (22)
|RE: Tech: A font for your song book.
|02 Apr 14
I was fond of Ariel Rounded Bold for my songbook, but the print-on-demand people I use to print it did not have that unless I embedded it (which I do not know how to do), so I use Ariel Bold in 12. Bold helps to see it. Since most of what is in my songbook are long ballads, it is important that lines fit on one line - the book is 350 pages already. It is a compromise between big enough to see and keeping the ballads to no more than three pages.


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Tamale Teaching Hospital opens poly clinic
The Tamale Teaching Hospital (TTH), has officially opened its poly clinic to the public. The poly Clinic situated at antenatal clinic around the old maternity and gynecology ward was opened yesterday. Residents seeking medical care for common ailments are supposed
2 arrested in Tamale for not wearing nose mask
Two persons have been arrested by the northern police command for failing to comply with the Imposition of Restrictions on wearing nose masks. The two were arrested at about 10:30am at the at the forecourt of the Northern Regional police
N/R: Teenagers in the streets on a rise
School going children on the street is a major problem in Northern region. The phenomenon of children living in the streets have been attributed to irresponsible parenting. Some residents within the Tamale metropolis want relevant authorities such as the assembly to turn their attention to
S/R: Abu Jinapor smuggling people to our constituency, NDC alleges
The NDC in the Damongo Constituency in the Savannah region has accused the Deputy Chief of Staff, Samuel Abu Jinapor and his supporters of smuggling in people to the constituency to register. Since the beginning of the exercise on Tuesday, June 30, the NDC