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The 22 Most Hilariously Accurate Moments From "Being Canadian"
"Canada is a feeling," the movie producer told BuzzFeed.
1. When a group of Americans were asked to name the nation's capital.
2. When another American (who is also called Kathy Griffin) laid out everything she knew about us.
3. When we get asked if we know "Steve" from Canada. And when we do.
4. Or if we actually live in igloos. And when we do (just kidding).
5. When producer Robert Cohen admitted something we, as Canadians, are all guilty of.
6. Whenever you ~reveal~ yourself to non-Canadians.
7. When former prime minister Kim Campbell was asked to explain Canada's history in a few words:
8. When these American teens were asked if our history was ever taught.
9. When we prided ourselves with building the super vital Canadarm for the space shuttle, and American Ben Stiller wanted to clarify that it was just the arm we celebrated...
10. And when Russell Peters perfectly captured the victoriousness we feel when anything or anyone is ours.
11. When a woman randomly stopped and gave Robert money to create his film after seeing the movie logo on the car.
12. When journalist Manisha Krishnan explains the few times we accumulate "street cred" as a nation:
13. When Mike Myers tried to make "Canadian cuisine" analogous:
14. When the filmmaker tried to talk to Harper but he was out buying snow tires, according to his gate guards.
15. When Alex Trebek explained how our humour is superior*.
16. Explain further, Malcolm Gladwell:
17. When this truth about our non-American identity identity was plainly laid out:
18. When Howie Mandel shared our confused frustration over why our neighbours know nothing about us.
19. And the feeling that immediately follows: Sadness :-(.
20. When Shatner vulnerably talked about our constant insecurities.
21. When Catherine O'Hara explained our endearing habit of adding "eh?" to the end of thoughts.
22. But mostly, and most accurately, when Robert attended the Vancouver Canada Day parade and realized the diverse and quirky interpretations of patriotism is exactly what "being Canadian" is all about.
Even after finishing the movie, Robert wished he could have captured a lot more about our national identities. "I wish there was a way that the movie could convey the supercool feelings about being Canadian," he told BuzzFeed Canada. "Something about Canada... it's this amazingly rare mix of something. Canada is a feeling, and it's hard to describe the feeling."

subset: commoncrawl


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Appearance and Reality (An inaugural lecture as Director of the University of London's Institute of Philosophy Given in the University of London on March 6, 2007)
I'd like to begin, if I may, by repeating myself. When I spoke at the Institute's official launch last June, I quoted W.V. Quine's remark that logic is an old subject, and since 1879 it has been a great one; and I commented that whatever the truth of this, it is undeniably true that philosophy is an old subject and has been a great one since the 5th century BC. The foundation of an institute of philosophy in the University of London has been, in my opinion, a great thing for philosophy and for the University. Our mission is to promote and support philosophy of the highest quality in all its forms, inside and outside the university. With our programmes of events, fellowships and research facilitation, I think we have been carrying out this mission pretty well since our foundation in 2005. But I have already said enough in public about the Institute. Given the occasion, it is appropriate for me to say something instead about philosophy itself.
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Results 19186 - 19200 from 20664 in "News"
TVN Chooses Leader LV5490 for UHD-HDR Bundesliga OB Tests
Hannover-based TVN MOBILE PRODUCTION, one of Europe's largest outside broadcast fleet operators, has ordered five Leader LV5490 test instruments for use in its first UHD-HDR mobile production truck. Logic Media Solutions, Leader's Darmstadt-based channel partner, supported TVN during pre-purchase evaluation and will complete the delivery.
TVN Group Chooses Calrec for 5.1 Mix
TVN is Host Broadcaster for the 2017/18 UEFA Champions League final in Kyiv
The UEFA Champions League final – the biggest match in club football – is being contested between two of the stellar names in the world game: Real Madrid have lifted the trophy in each of the last two seasons and are looking to claim it for a record 13th time overall. Liverpool are eyeing a sixth final victory.
TVN Mobile Production Chooses XT-VIA To Drive Industry´s Most Innovative OB Concept TVN-Ü6
TVN Mobile Production, part of Germany's TVN Group, is upgrading its XT3 live production server fleet to EVS' next-generation XT-VIA servers. The Hannover-based mobile television services specialist is installing the industry's most powerful multi-channel servers in its TVN-Ü3, TVN-Ü4, TVN-Ü5 and in its all new TVN-Ü6, the most innovative OB concept on the market that has just been introduced. The new servers will be used for its premium live productions of Bundesliga and Bundesliga 2 football games for DFL host broadcaster Sportcast, as well as the UEFA competitions Champions League, Europa League and European Qualifiers.
TVN MOBILE PRODUCTION relies on Sennheiser: Always on the move and "DD ready"!
The special trademark of German production company TVN is its fleet of outside broadcast trucks. Designed by experienced engineers, these trucks are used throughout Europe for producing sporting events, shows and concerts for television in optimum audio and video quality. Wireless gear of Sennheiser's 3000/5000 and 2000 series ensures that the sound engineers are perfectly equipped to meet all challenges of national and international events – even under the demanding conditions posed by the second Digital Dividend.
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Additionally to increasingly improving image quality, TV channels and film producers want to offer their viewers a corresponding sound experience. To produce and continue to develop this, the TVN Group has established a 3D audio studio at its headquarters in Hannover, Germany. The studio was presented to great public interest.
TVN relies on Sony equipment for UHD broadcasts
TVN is strongly expanding its UHD capacities: the film and TV production company from Hannover is upgrading one of its existing OB trucks with further Sony UHD equipment. 12 UHD HDC-4300 live camera systems, two CineAlta PMW-F55 cameras, the XVS-8000 video switcher and PWS-4500 the production server system were recently integrated. The 4K equipment has already successfully completed the UHD first broadcasts of football matches for German television. The TV service provider plans to increase its mobile 4K capacities further in 2017.
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TVN Trusts in Lawo Technology for Hurricane Festival
TVN with the First Ikegami High-Speed Camera in Germany
TVN-Ü2HD: Upgrade to HD/3D Production and Riedel MediorNet
TVN24 becomes first worldwide broadcaster to future-proof its news production capabilities with Sony PXW-Z750
TVN24, the largest and the most-watched 24-hours news channel in Poland, becomes the first customer to receive ten Sony PXW-Z750 4K camcorders to future-proof its infrastructure for advanced 4K/UHD output and increase the agility of its news broadcasting operations. As an existing Sony customer, TVN24's investment into the latest PXW-Z750 4K camcorders will help replace more than 80 PDW-700 and PMW-500 Sony shoulder camcorders currently in use. With the Z750 camcorders, the news channel's production team will now be able to shoot in 4K, High Dynamic Range (HDR) and High Frame Rate (HFR), delivering 4K image quality with high sensitivity and vivid colour reproduction, ideal for news and live production.
TVNZ at the FIFA World Cup 2010
TVP Again Chooses BFE for Upgrade of OB Van Broadcast Control System
Poland's largest TV network reassures its trust in German broadcast specialist BFE for an upgrade of the on-board control system in their 14 camera HD OB van. JBD, BFE's partner for KSC in the Polish market sealed the deal.


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This Is Telling: It's Impossible to Imagine Donald Trump Giving the Gettysburg AddressNews at Home
tags: Abraham Lincoln, Gettysburg Address, democracy, Trump
Louis P. Masur, Distinguished Professor of American Studies and History at Rutgers University, is author of Lincoln's Last Speech: Wartime Reconstruction and the Crisis of Reunion.
One hundred and fifty-five years ago, Abraham Lincoln delivered the Gettysburg Address, his paean to democracy. Donald Trump has compared himself to Lincoln and has stated falsely that Lincoln's Address was universally panned at the time. But the differences between Lincoln and Trump couldn't be starker. Lincoln came from a poor family, lived in a frontier cabin, and was self-educated; Trump comes from wealth, lived in a penthouse, and attended an Ivy League university. Lincoln opposed nativism; Trump champions it. Lincoln celebrated America's global role, calling it "the last best hope of earth"; Trump seeks to withdraw from the world order, erect protective barriers, and place "America first."
Perhaps the greatest difference between Lincoln and Trump concerns attitudes toward democracy. For Lincoln, democracy was everything and constituted the primary reason not to allow the nation to be destroyed; by comparison, for the past two years, Trump has waged war on democratic institutions.
Lincoln proclaimed his faith in democracy and the meaning of the Civil War on July 4, 1861, when he told Congress that the rebellion "presents to the whole family of man, the question, whether a constitutional republic, or a democracy—a government of the people by the same people—can or cannot, maintain its territorial integrity against its own domestic foes." Should the rebellion succeed, it would "put an end to free government upon the earth."
It galled him that a minority would resort to bullets rather than ballots in response to his election. There were many ways to contest an unfavorable political outcome—for example, organize and vote in future elections or call for a constitutional convention—but rebellion was not one of them. In 1864, with war raging and his reelection in doubt, Lincoln insisted that elections still be held. Consider that during World War II, Great Britain postponed general elections until the war was won and Lincoln's actions seem even more remarkable. His commitment to democracy was unassailable. Following his victory, he declared "we cannot have free government without elections, and if the rebellion could force to forgo, or postpone, a national election, it might fairly claim to have already conquered and ruined us."
Rather than encouraging democracy, Trump and today's Republican party seem intent on curtailing it. Trump has denounced the media, used the Justice Department as his personal domain, and has continued to act autocratically. Rather than treat elections with reverence, he has falsely alleged fraud in Florida's recent vote and opposed a recount. Republican politicians have made it harder, not easier, for Americans to vote. They have suppressed the vote of the poor and nonwhites by using a variety of tactics, including enacting voter identification laws, purging voters from the rolls, and reducing the number of polling places.
Some of this, of course, is politics as usual. Lincoln was no innocent and, in the election of 1864, he supported efforts to keep Democrats in the army from voting while promoting the votes of Republican soldiers in those states that allowed it. But Lincoln never wavered in his belief in democracy. Indeed, on April 11, 1865 he publicly endorsed the right to vote for black men who were educated and had served in the military. Hearing this, John Wilkes Booth became outraged and vowed it would be the last speech Lincoln ever gave. Three days later, he acted on his threat.
Lincoln offered his supreme tribute to democracy in the Gettysburg Address. The speech began by grounding the meaning of America in the Declaration of Independence and it ended by reaffirming that "government of the people, by the people, for the people, shall not perish from the earth." These past two years have rightly generated anxiety about the fate of democracy in America. As various observers have recently noted, a pro-democracy movement is blossoming. Preliminary numbers suggest that more than 49 per cent of eligible voters cast their ballots on election day, and some states surpassed 60%. This was the highest turnout for midterm elections in over 100 years.
Ballot measures that triumphed suggest citizens are fighting back. In Florida, voting rights were restored to over a million people with felony convictions and other states passed measures to simplify the registration process and reduce gerrymandering. There is talk of universal voting by mail and automatic voter registration. Thanks to the tireless efforts of those who are committed to the right to vote, democracy has a long way to go before it perishes. Lincoln would be pleased.
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every time there is an accusation against Aldi-Coles or Woolies.are behimd it. Nobody complains about Woollies and coles stealing millions and billions of dollars thrue Poker machine outlets ,imagine Aldi would do that and the outcry,germans steal oure money ,but now its their own!
Aldi takes Union to court over misleading claims
Aldi has taken the Transport Workers Union to Federal Court, following what the supermarket claims is a string of false and misleading claims.
The TWU has made a number of claims toward Aldi, including that its drivers have faced harassment when they have raised concerns over fatigue with management, with one driver quoted as being told, "Everyone else is doing it. You are the only one with a problem."
However, the supermarket has refuted these claims and said it will let the courts determine the matter.
"The TWU has made a series of allegations against Aldi," an Aldi spokesperson told Inside Retail. "We say these allegations are false."
According to the TWU, the supermarket's alleged actions could have far-reaching consequences for those who raise concerns about safety in the workplace, environmental or rights abuses.
"Transport workers are sending a clear message to Aldi to take road safety seriously and make sure its transport workers, the transport workers in its supply chain, and other road users can return home to their families in one piece," Nick McIntosh, TWU national assistant secretary, said in a statement to Aldi over the Christmas period.
"Coles and Woolworths have recognised their critical role in improving road safety. Aldi needs to stop attacking truck drivers and instead sit down in good faith and be part of the solution."
Access exclusive analysis, locked news and reports with Inside Retail Weekly. Subscribe today and get our premium print publication delivered to your door every week.
2 comments
peterpost posted on May 9, 2019
im tired and sick of USA sanctions against "IRAN",today I bought some dates at aldi ,$3 for 2-3 kilograms whats left for the workers ,the price should be at least $10 and $2 handed on to the growers in Iran and workers ,I myself a fruitpicker know what work is and underpayment ,so sell them for more and hand on the money to the workers in Iran,fuck America! Log in to Reply
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David Bruce: William Shakespeare's JULIUS CAESAR: A Retelling in Prose — Cast of Characters — Act 1, Scene 1
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Patients with very long-chain acyl-CoA dehydrogenase deficiency (VLCADD) can present with life-threatening cardiac arrhythmias. The pathophysiological mechanism is unknown. We reprogrammed fibroblasts from one mildly and one severely affected VLCADD patient, into human induced pluripotent stem cells (hiPSCs) and differentiated these into cardiomyocytes (VLCADD-CMs). VLCADD-CMs displayed shorter action potentials (APs), more delayed afterdepolarizations (DADs) and higher systolic and diastolic intracellular Ca2+ concentration ([Ca2+]i) than control CMs. The mitochondrial booster resveratrol mitigated the biochemical, electrophysiological and [Ca2+]i changes in the mild but not in the severe VLCADD-CMs. Accumulation of potentially toxic intermediates of fatty acid oxidation was blocked by substrate reduction with etomoxir. Incubation with etomoxir led to marked prolongation of AP duration and reduced DADs and [Ca2+]i in both VLCADD-CMs. These results provide compelling evidence that reduced accumulation of fatty acid oxidation intermediates, either by enhanced fatty acid oxidation flux through increased mitochondria biogenesis (resveratrol) or by inhibition of fatty acid transport into the mitochondria (etomoxir), rescues pro-arrhythmia defects in VLCADD-CMs and open doors for new treatments.
AssuntosAcil-CoA Desidrogenase de Cadeia Longa/deficiência , Arritmias Cardíacas/prevenção & controle , Síndrome Congênita de Insuficiência da Medula Óssea/fisiopatologia , Compostos de Epóxi/farmacologia , Ácidos Graxos/química , Erros Inatos do Metabolismo Lipídico/fisiopatologia , Mitocôndrias/fisiologia , Doenças Mitocondriais/fisiopatologia , Doenças Musculares/fisiopatologia , Miócitos Cardíacos/fisiologia , Resveratrol/farmacologia , Potenciais de Ação , Arritmias Cardíacas/etiologia , Eletrofisiologia Cardíaca , Síndrome Congênita de Insuficiência da Medula Óssea/complicações , Ácidos Graxos/metabolismo , Humanos , Células-Tronco Pluripotentes Induzidas , Erros Inatos do Metabolismo Lipídico/complicações , Doenças Mitocondriais/complicações , Doenças Musculares/complicações , Miócitos Cardíacos/efeitos dos fármacos , Oxirredução
BACKGROUND: Neutral lipid storage disease with myopathy (NLSDM) is a rare lipid metabolism disorder. In this study, we evaluated some circulating miRNAs levels in serum samples and the MRI of three affected siblings. METHODS: Three members of one NLSDM family were identified: two brothers and one sister. Muscles of lower and right upper extremities were studied by MRI. Expression profile of miRNAs, obtained from serum samples, was detected using qRT-PCR. RESULTS: Two brothers presented with progressive skeletal myopathy, while the sister had severe hepatosteatosis and diabetes. NLSDM patients showed a significant increase of muscle-specific miRNAs expression compared with healthy subjects. We found a correlation between hepatic damage and elevation of miRNAs expression profile of liver origin. CONCLUSIONS: The dysregulation of miRNAs might represent an indicator of skeletal and hepatic damage and it might be useful to monitor the progression of NLSDM.
AssuntosBiomarcadores/sangue , Erros Inatos do Metabolismo Lipídico/sangue , Erros Inatos do Metabolismo Lipídico/genética , MicroRNAs/sangue , Doenças Musculares/sangue , Doenças Musculares/genética , Idade de Início , Feminino , Humanos , Lipase/genética , Erros Inatos do Metabolismo Lipídico/diagnóstico por imagem , Fígado/metabolismo , Fígado/patologia , Imagem por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Músculo Esquelético/diagnóstico por imagem , Doenças Musculares/diagnóstico por imagem , Mutação/genética , Irmãos , Tomografia Computadorizada por Raios X
cis-5-Tetradecenoic (cis-5) and myristic (Myr) acids predominantly accumulate in patients affected by very long-chain acyl-CoA dehydrogenase (VLCAD) deficiency. They commonly manifest myopathy with muscular pain and rhabdomyolysis, whose underlying mechanisms are poorly known. Thus, in the present study we investigated the effects of cis-5 and Myr on mitochondrial bioenergetics and Ca2+ homeostasis in rat skeletal muscle. cis-5 and Myr decreased ADP-stimulated (state 3) and CCCP-stimulated (uncoupled) respiration, especially when mitochondria were supported by NADH-linked as compared to FADH2-linked substrates. In contrast, these fatty acids increased resting respiration (state 4). Similar effects were observed in skeletal muscle fibers therefore validating the data obtained with isolated mitochondria. Furthermore, cis-5 and Myr markedly decreased mitochondrial membrane potential and Ca2+ retention capacity that were avoided by cyclosporin A plus ADP and ruthenium red, indicating that cis-5 and Myr induce mitochondrial permeability transition (MPT). Finally, docosanoic acid did not disturb mitochondrial homeostasis, indicating selective effects for Myr and cis-5. Taken together, our findings indicate that major long-chain fatty acids accumulating in VLCAD deficiency behave as metabolic inhibitors, uncouplers of oxidative phosphorylation and MPT inducers. It is presumed that these pathomechanisms contribute to the muscular symptoms and rhabdomyolysis observed in patients affected by VLCAD deficiency.
AssuntosAcil-CoA Desidrogenase de Cadeia Longa/deficiência , Síndrome Congênita de Insuficiência da Medula Óssea/metabolismo , Erros Inatos do Metabolismo Lipídico/metabolismo , Mitocôndrias/efeitos dos fármacos , Doenças Mitocondriais/metabolismo , Músculo Esquelético/efeitos dos fármacos , Doenças Musculares/metabolismo , Ácidos Mirísticos/toxicidade , Acil-CoA Desidrogenase de Cadeia Longa/metabolismo , Animais , Cálcio/metabolismo , Metabolismo Energético/efeitos dos fármacos , Homeostase/efeitos dos fármacos , Potencial da Membrana Mitocondrial/efeitos dos fármacos , Mitocôndrias/metabolismo , Mitocôndrias/fisiologia , Músculo Esquelético/metabolismo , Consumo de Oxigênio/efeitos dos fármacos , Permeabilidade/efeitos dos fármacos , Ratos Wistar
AssuntosFraturas do Fêmur , Lamina Tipo A/genética , Erros Inatos do Metabolismo Lipídico , Lipodistrofia , Mutação Puntual , Adolescente , Fraturas do Fêmur/diagnóstico por imagem , Fraturas do Fêmur/genética , Humanos , Erros Inatos do Metabolismo Lipídico/diagnóstico , Erros Inatos do Metabolismo Lipídico/genética , Lipodistrofia/diagnóstico por imagem , Lipodistrofia/genética , Masculino
BACKGROUND: Chanarin Dorfman Syndrome (CDS) is a rare autosomal recessive disorder characterized by the multisytemic accumulation of neutral lipids inside the cytoplasmic lipid droplets. This condition is caused by mutations in the abhydrolase domain containing 5 gene (ABHD5). In CDS the skin involvement is the prevalent and always observed clinical feature, consisting of a non-bullous congenital ichthyosiform erythroderma (NCIE). Moreover, a variable involvement of the liver and neuromuscular system can be also observed. In this report, we aimed to perform the clinical and genetic characterization of a patient affected by CDS with atypical dermatological findings, considering this rare inborn error of neutral lipid metabolism. METHODS: Genomic DNA samples obtained from patient and his parents were used to perform the sequencing of the ABHD5 exons and their intron/exon boundaries. Bioinformatic analyses were performed to investigate the possible effect of the identified mutation on protein structure. RESULTS: Here we present the case of a 29-year-old male patient with CDS, who, for long time, has been misdiagnosed as pityriasis rubra pilaris (PRP). He has a history of increasing hyperlipidemia; hepatomegaly associated with hepatosteatosis was also detected. ABHD5 molecular analysis revealed a novel missense mutation, the c.811G > A (p.G271R). Bioinformatic investigations showed that the variant has a deleterious effect on ABHD5 function, probably causing an incorrect folding of the mutant protein. CONCLUSIONS: These results highlihts the importance of genetic testing for ABHD5 in unresolved cases of patients presenting unusual skin lesions, that resemble PRP, associated with a history of hyperlipidemia and nonalcoholic fatty liver.
Assuntos1-Acilglicerol-3-Fosfato O-Aciltransferase/genética , Eritrodermia Ictiosiforme Congênita/diagnóstico , Ictiose Lamelar/diagnóstico , Erros Inatos do Metabolismo Lipídico/diagnóstico , Doenças Musculares/diagnóstico , Pitiríase Rubra Pilar/diagnóstico , Adulto , Erros de Diagnóstico , Predisposição Genética para Doença , Humanos , Eritrodermia Ictiosiforme Congênita/genética , Eritrodermia Ictiosiforme Congênita/patologia , Ictiose Lamelar/genética , Ictiose Lamelar/patologia , Gotículas Lipídicas/metabolismo , Erros Inatos do Metabolismo Lipídico/genética , Erros Inatos do Metabolismo Lipídico/patologia , Lipídeos/genética , Masculino , Doenças Musculares/genética , Doenças Musculares/patologia , Mutação de Sentido Incorreto , Pitiríase Rubra Pilar/genética , Pitiríase Rubra Pilar/patologia , Dobramento de Proteína
Exocrine pancreatic insufficiency in children can lead to lifelong complications related to malnutrition and poor growth. The clinical presentation can be subtle in the early stages of insufficiency as the large functional capacity of the pancreas is gradually lost. The pediatrician plays a crucial role in the early identification of these children to ensure a timely referral so that a diagnosis can be made and therapy initiated. Early nutritional therapy allows for prevention and correction of deficiencies, which leads to improved outcomes and survival. When insufficiency is suspected, the workup should start with an indirect test of exocrine pancreatic function, such as fecal elastase, to establish the diagnosis. Once a diagnosis is established, further testing to delineate the etiology should be pursued, with cystic fibrosis being high on the differential list and assessed for with a sweat test. Assessment of anthropometry at every visit is key, as is monitoring of laboratory parameters and physical examination findings that are suggestive of malabsorption and malnutrition. The mainstay of management is administration of exogenous pancreatic enzymes to facilitate digestion and absorption. [Pediatr Ann. 2019;48(11):e441-e447.].
AssuntosTranstornos da Nutrição Infantil/etiologia , Insuficiência Pancreática Exócrina/diagnóstico , Acil-CoA Desidrogenase de Cadeia Longa/deficiência , Anus Imperfurado/complicações , Criança , Transtornos da Nutrição Infantil/diagnóstico , Transtornos da Nutrição Infantil/terapia , Quimotripsina/metabolismo , Síndrome Congênita de Insuficiência da Medula Óssea/complicações , Fibrose Cística/complicações , Gorduras na Dieta/metabolismo , Displasia Ectodérmica/complicações , Terapia de Reposição de Enzimas , Insuficiência Pancreática Exócrina/etiologia , Insuficiência Pancreática Exócrina/terapia , Fezes/enzimologia , Transtornos do Crescimento/complicações , Perda Auditiva Neurossensorial/complicações , Humanos , Hipotireoidismo/complicações , Deficiência Intelectual/complicações , Erros Inatos do Metabolismo Lipídico/complicações , Doenças Mitocondriais/complicações , Doenças Musculares/complicações , Nariz/anormalidades , Avaliação Nutricional , Pâncreas/diagnóstico por imagem , Pâncreas/fisiologia , Pancreatopatias/complicações , Elastase Pancreática/metabolismo , Testes de Função Pancreática , Pancreatite Crônica/complicações , Pancreatite Crônica/etiologia , Síndrome de Shwachman-Diamond/complicações , Esteatorreia/etiologia , Tripsinogênio/sangue
OBJECTIVE: To determine the incidence and mutational types of fatty acid oxidation disorders (FAOD) in central-northern region of Guangxi. METHODS: A total of 62 953 neonates were screened for FAOD during December 2012 and December 2017. Acyl-carnitine profiling of neonatal blood sample was performed by tandem mass spectrometry using dry blood spots on a filter paper. The diagnosis of FAOD was confirmed by organic acid profiling of urea and genetic testing. RESULTS: Eighteen cases of FAOD were diagnosed among the 62 953 neonates. Among these, primary carnitine deficiency (PCD) was the most common type (n=13), which was followed by short-chain acyl-CoA dehydrogenase deficiency (SCADD) (n=2), medium-chain acyl-CoA dehydrogenase deficiency (MCADD) (n=1), multiple acyl-CoA dehydrogenase deficiency (MADD) (n=1), and carnitine palmitoyltransferase II deficiency (CPT II D) (n=1). Genetic testing has revealed two previously unreported variants, i.e., c.337G to A (p.Gly113Arg) of ACADS gene and c.737G TO T (p.Gly246Val) of ETFA gene. CONCLUSION: PCD is the most common FAOD in central-northern Guangxi. Tandem mass spectrometry combined with genetic testing may facilitate early diagnosis of FAOD.
AssuntosErros Inatos do Metabolismo Lipídico/diagnóstico , Erros Inatos do Metabolismo Lipídico/genética , Acil-CoA Desidrogenase/deficiência , Acil-CoA Desidrogenase/genética , Carnitina/sangue , Carnitina O-Palmitoiltransferase/deficiência , China , Flavoproteínas Transferidoras de Elétrons/genética , Humanos , Recém-Nascido , Erros Inatos do Metabolismo/diagnóstico , Deficiência Múltipla de Acil Coenzima A Desidrogenase/diagnóstico , Triagem Neonatal , Espectrometria de Massas em Tandem
OBJECTIVE: To detect potential variation in an ethnic Han Chinese family affected with late-onset lipid storage myopathy. METHODS: Next generation sequencing (NGS) was used to screen disease-related genes in the proband. Suspected mutation was validated with PCR and Sanger sequencing in two patients, their father, and 100 healthy controls. RESULTS: Heterozygous c.770A>G (p.Tyr257Cys) and c.1395dupT (p.Gly466Tryfs) mutation were detected in the two patients. Their father was found to be heterozygous for the c.770A>G (p.Tyr257Cys) mutation, while the c.1395dupT (p.Gly466Tryfs) variation was not reported previously and not found among the healthy controls. CONCLUSION: Mutations of the ETFDH gene probably underlie the pathogenesis in this family. The novel c.1395dupT (p.Gly466Tryfs) has enriched the mutation spectrum of EDFDH gene.
AssuntosFlavoproteínas Transferidoras de Elétrons/genética , Proteínas com Ferro-Enxofre/genética , Erros Inatos do Metabolismo Lipídico/genética , Distrofias Musculares/genética , Oxirredutases atuantes sobre Doadores de Grupo CH-NH/genética , Grupo com Ancestrais do Continente Asiático , Heterozigoto , Sequenciamento de Nucleotídeos em Larga Escala , Humanos , Mutação
Retinopathy of prematurity (ROP) is a biphasic disease in which the first phase is characterized by high oxygen tension leading to vaso-obliteration in the retina. Pearson syndrome is a rare multisystem mitochondrial disease with a defect in cellular respiration. The authors describe a patient with Pearson syndrome and delayed onset of ROP at a postconceptual age of 42 weeks. The proposed mechanistic theory was the increased oxygen use associated with the metabolic impairments in Pearson syndrome counterbalancing the effects of supplemental oxygen during the vaso-obliterative stage of ROP. [J Pediatr Ophthalmol Strabismus. 2019;56:e60-e64.].
AssuntosAcil-CoA Desidrogenase de Cadeia Longa/deficiência , Síndrome Congênita de Insuficiência da Medula Óssea/diagnóstico , Recém-Nascido de Baixo Peso , Erros Inatos do Metabolismo Lipídico/diagnóstico , Doenças Mitocondriais/diagnóstico , Doenças Musculares/diagnóstico , Oxigênio/metabolismo , Retinopatia da Prematuridade/diagnóstico , Acil-CoA Desidrogenase de Cadeia Longa/metabolismo , Síndrome Congênita de Insuficiência da Medula Óssea/metabolismo , Progressão da Doença , Feminino , Angiofluoresceinografia/métodos , Seguimentos , Fundo de Olho , Idade Gestacional , Humanos , Recém-Nascido , Erros Inatos do Metabolismo Lipídico/metabolismo , Doenças Mitocondriais/metabolismo , Doenças Musculares/metabolismo , Retinopatia da Prematuridade/metabolismo , Fatores de Tempo
The ABCG5/G8 heterodimer is the primary neutral sterol transporter in hepatobiliary and transintestinal cholesterol excretion. Inactivating mutations on either the ABCG5 or ABCG8 subunit cause Sitosterolemia, a rare genetic disorder. In 2016, a crystal structure of human ABCG5/G8 in an apo state showed the first structural information on ATP-binding cassette (ABC) sterol transporters and revealed several structural features that were observed for the first time. Over the past decade, several missense variants of ABCG5/G8 have been associated with non-Sitosterolemia lipid phenotypes. In this review, we summarize recent pathophysiological and structural findings of ABCG5/G8, interpret the structure-function relationship in disease-causing variants and describe the available evidence that allows us to build a mechanistic view of ABCG5/G8-mediated sterol transport.
AssuntosMembro 5 da Subfamília G de Transportadores de Cassetes de Ligação de ATP/química , Membro 8 da Subfamília G de Transportadores de Cassetes de Ligação de ATP/química , Sistema Biliar/metabolismo , Colesterol/metabolismo , Lipoproteínas/química , Fígado/metabolismo , Membro 5 da Subfamília G de Transportadores de Cassetes de Ligação de ATP/biossíntese , Membro 5 da Subfamília G de Transportadores de Cassetes de Ligação de ATP/metabolismo , Membro 8 da Subfamília G de Transportadores de Cassetes de Ligação de ATP/biossíntese , Membro 8 da Subfamília G de Transportadores de Cassetes de Ligação de ATP/metabolismo , Animais , Catálise , Homeostase , Humanos , Hipercolesterolemia/metabolismo , Enteropatias/metabolismo , Erros Inatos do Metabolismo Lipídico/metabolismo , Lipoproteínas/biossíntese , Lipoproteínas/metabolismo , Fitosteróis/efeitos adversos , Fitosteróis/metabolismo
Mitochondrial DNA (mtDNA) genome integrity is essential for proper mitochondrial respiratory chain function to generate cellular energy. Nuclear genes encode several proteins that function at the mtDNA replication fork, including mitochondrial single-stranded DNA-binding protein (SSBP1), which is a tetrameric protein that binds and protects single-stranded mtDNA (ssDNA). Recently, two studies have reported pathogenic variants in SSBP1 associated with hearing loss, optic atrophy, and retinal degeneration. Here, we report a 14-year-old Chinese boy with severe and progressive mitochondrial disease manifestations across the full Pearson, Kearns-Sayre, and Leigh syndromes spectrum, including infantile anemia and bone marrow failure, growth failure, ptosis, ophthalmoplegia, ataxia, severe retinal dystrophy of the rod-cone type, sensorineural hearing loss, chronic kidney disease, multiple endocrine deficiencies, and metabolic strokes. mtDNA genome sequencing identified a single large-scale 5 kilobase mtDNA deletion (m.8629_14068del5440), present at 68% and 16% heteroplasmy in the proband's fibroblast cell line and blood, respectively, suggestive of a mtDNA maintenance defect. On trio whole exome blood sequencing, the proband was found to harbor a novel de novo heterozygous mutation c.79G>A (p.E27K) in SSBP1. Size exclusion chromatography of p.E27K SSBP1 revealed it remains a stable tetramer. However, differential scanning fluorimetry demonstrated p.E27K SSBP1 relative to wild type had modestly decreased thermostability. Functional assays also revealed p.E27K SSBP1 had altered DNA binding. Molecular modeling of SSBP1 tetramers with varying combinations of mutant subunits predicted general changes in surface accessible charges, strength of inter-subunit interactions, and protein dynamics. Overall, the observed changes in protein dynamics and DNA binding behavior suggest that p.E27K SSBP1 can interfere with DNA replication and precipitate the introduction of large-scale mtDNA deletions. Thus, a single large-scale mtDNA deletion (SLSMD) with manifestations across the clinical spectrum of Pearson, Kearns-Sayre, and Leigh syndromes may result from a nuclear gene disorder disrupting mitochondrial DNA replication.
AssuntosAcil-CoA Desidrogenase de Cadeia Longa/deficiência , Síndrome Congênita de Insuficiência da Medula Óssea/genética , DNA Mitocondrial/genética , Proteínas de Ligação a DNA/genética , Síndrome de Kearns-Sayre/genética , Doença de Leigh/genética , Erros Inatos do Metabolismo Lipídico/genética , Doenças Mitocondriais/genética , Proteínas Mitocondriais/genética , Doenças Musculares/genética , Mutação , Acil-CoA Desidrogenase de Cadeia Longa/genética , Adolescente , Sequência de Aminoácidos , Linhagem Celular , Criança , Síndrome Congênita de Insuficiência da Medula Óssea/complicações , Proteínas de Ligação a DNA/química , Proteínas de Ligação a DNA/metabolismo , Heterozigoto , Humanos , Síndrome de Kearns-Sayre/complicações , Doença de Leigh/complicações , Erros Inatos do Metabolismo Lipídico/complicações , Masculino , Doenças Mitocondriais/complicações , Proteínas Mitocondriais/química , Proteínas Mitocondriais/metabolismo , Simulação de Dinâmica Molecular , Doenças Musculares/complicações , Fenótipo , Estabilidade Proteica , Estrutura Quaternária de Proteína , Deleção de Sequência , Sequenciamento Completo do Exoma
PURPOSE OF REVIEW: This review is a comprehensive update on recent discoveries on the genetics of early-onset coronary artery disease (EOCAD), and how those findings can be translated to advance its medical management. RECENT FINDINGS: To date, a total of 266 common variants of modest effect size have been reported to be associated with CAD, but many still warrant functional studies. Rare variants impacting the function of at least 10 genes are now well characterized in Mendelian EOCAD. Estimations of minor allele frequencies in multiple ancestries from large genetic databases have allowed us to estimate the prevalence of Mendelian forms of EOCAD. In fact, the prevalence of Mendelian mutations varies markedly between ancestries, ranging from 1â:â289 to 1â:â153 for familial hypercholesterolemia. Mendelian forms of EOCAD support three major biological pathways, including lipid metabolism, vascular wall integrity and function, and thrombosis. Furthermore, combining common variants of modest effect into polygenic risk scores (PRS) has shown to be effective at identifying individuals at high risk of CAD. SUMMARY: Mendelian forms of EOCAD highlight the importance of lipid metabolism, yet prevalence in many non-European populations remains to be clarified. Polygenic EOCAD affects more individuals and, in many cases, confers a higher risk of EOCAD than rare Mendelian mutations. Thus, sequencing of target genes and the derivation of PRSs can be used to identify high-risk patients, leading to more personalized therapeutic approaches.
AssuntosDoença da Artéria Coronariana/genética , Idade de Início , Testes Genéticos , Genética Populacional , Humanos , Erros Inatos do Metabolismo Lipídico/genética , Fatores de Risco , Trombofilia/genética , Doenças Vasculares/genética
Medium-chain-triglycerides (MCT) are widely applied in the treatment of long-chain fatty acid oxidation disorders (lcFAOD). Long-term treatment with MCT led to a sexually dimorphic response in the mouse model of very-long-chain-acyl-CoA-dehydrogenase-deficiency (VLCAD-/-) with the subsequent development of a metabolic syndrome in female mice. In order to evaluate the molecular mechanisms responsible for this sex specific response we performed a comprehensive metabolic phenotyping, SILAC-based quantitative proteomics and characterized the involved signaling pathways by western blot analysis and gene expression. WT and VLCAD-/- mice showed strong sex-dependent differences in basal metabolism and expression of proteins involved in the distinct metabolic pathways, even more prominent after treatment with octanoate. The investigation of molecular mechanisms responsible for the sexual dimorphisms delineated the selective activation of the ERK/mTORc1 signaling pathway leading to an increased biosynthesis and elongation of fatty acids in VLCAD-/- females. In contrast, octanoate induced the activation of ERK/PPARγ pathway and the subsequent upregulation of peroxisomal ßoxidation in males. We here provide first evidence that sex has to be considered as important variable in disease phenotype. These findings may have implications on treatment strategies in the different sexes.
AssuntosAcil-CoA Desidrogenase de Cadeia Longa/deficiência , Acil-CoA Desidrogenase de Cadeia Longa/metabolismo , Síndrome Congênita de Insuficiência da Medula Óssea/metabolismo , Ácidos Graxos/metabolismo , Erros Inatos do Metabolismo Lipídico/metabolismo , Doenças Mitocondriais/metabolismo , Doenças Musculares/metabolismo , Acil-CoA Desidrogenase de Cadeia Longa/genética , Animais , Caprilatos/metabolismo , Caprilatos/uso terapêutico , Síndrome Congênita de Insuficiência da Medula Óssea/genética , Síndrome Congênita de Insuficiência da Medula Óssea/terapia , Feminino , Deleção de Genes , Humanos , Erros Inatos do Metabolismo Lipídico/genética , Erros Inatos do Metabolismo Lipídico/terapia , Sistema de Sinalização das MAP Quinases , Masculino , Camundongos , Doenças Mitocondriais/genética , Doenças Mitocondriais/terapia , Doenças Musculares/genética , Doenças Musculares/terapia , Oxirredução , PPAR gama/metabolismo , Fatores Sexuais , Transdução de Sinais , Serina-Treonina Quinases TOR/metabolismo
Newborn screening is an incredibly useful tool for the early identification of many metabolic disorders, including fatty acid oxidation (FAO) disorders. In many cases, molecular tests are necessary to reach a final diagnosis, highlighting the need for a thorough evaluation of genes implicated in FAO disorders. Using the ClinGen (Clinical Genome Resource) clinical validity framework, thirty genes were analyzed for the strength of evidence supporting their association with FAO disorders. Evidence was gathered from the literature by biocurators and presented to disease experts for review in order to assign a clinical validity classification of Definitive, Strong, Moderate, Limited, Disputed, Refuted, or No Reported Evidence. Of the gene-disease relationships evaluated, 22/30 were classified as Definitive, three as Moderate, one as Limited, three as No Reported Evidence and one as Disputed. Gene-disease relationships with a Limited, Disputed, and No Reported Evidence were found on two, six, and up to four panels out of 30 FAO disorder-specific panels, respectively, in the National Institute of Health Genetic Testing Registry, while over 70% of the genes on panels are definitively associated with an FAO disorder. These results highlight the need to systematically assess the clinical relevance of genes implicated in fatty acid oxidation disorders in order to improve the interpretation of genetic testing results and diagnosis of patients with these disorders.
AssuntosÁcidos Graxos/metabolismo , Testes Genéticos , Erros Inatos do Metabolismo Lipídico/diagnóstico , Erros Inatos do Metabolismo Lipídico/genética , Predisposição Genética para Doença , Humanos , Recém-Nascido , Triagem Neonatal , Oxirredução , Reprodutibilidade dos Testes
BACKGROUND: Childhood fasting intolerance is a life-threatening problem associated with various inborn errors of metabolism. Plasma acylcarnitines reflect fatty acid oxidation and help determine fasting intolerance etiology. Pediatric reference values of plasma acylcarnitines upon fasting are not available, complicating interpretation of stress samples. METHODS: Retrospective analysis of supervised clinical fasting studies between 01/2005-09/2012. Exclusion criteria involved patients with (suspected) disorders, repeated tests or incomplete results. Remaining children were grouped according to age: group A (≤24 months), B (25-84 months) and C (≥85 months). Median and 2.5th to 97.5th percentiles of basic metabolic parameters and acylcarnitines were determined at start and end of testing on the ward and analyzed for significant differences (p<0.05). RESULTS: Out of 127 fasting studies, 48 were included: group A (n=13), B (n=23) and C (n=12). Hypoglycemia occurred in 21%. Children from group C demonstrated significantly higher end glucose concentrations while end ketone body concentrations were significantly lower compared to younger children. In all groups, free carnitine and C3-carnitine significantly decreased upon fasting, while C2-, C6-, C12:1-, C12-, C14:1-, C14-, C16:1- and C16-carnitine significantly increased. End concentrations of C6-, C12:1-, C12-, C14:1-, C14-, C16:1-, C16- and C18:1-carnitine were significantly lower in children ≥85 months compared to younger children. CONCLUSIONS: Fasting-induced counter-regulatory mechanisms to maintain energy homeostasis are age-dependent. This influences the changes in basic metabolic parameters and acylcarnitine profiles. Our data enable improved interpretation of the individual fasting response and may support assessment of minimal safe fasting times or treatment responses in patients.
AssuntosCarnitina/análogos & derivados , Jejum/sangue , Hipoglicemia/sangue , Estresse Fisiológico , Glicemia/análise , Carnitina/sangue , Criança , Pré-Escolar , Feminino , Homeostase , Humanos , Lactente , Erros Inatos do Metabolismo Lipídico/sangue , Masculino , Estudos Retrospectivos
A 2-day old term male infant was found to be hypotonic and minimally reactive during routine nursing care in the newborn nursery. At 40 hours of life, he was hypoglycemic and had intermittent desaturations to 70%. His mother had an unremarkable pregnancy and spontaneous vaginal delivery. The mother's prenatal serology results were negative for infectious risk factors. Apgar scores were 9 at 1 and 5 minutes of life. On day 1 of life, he fed, stooled, and voided well. Our expert panel discusses the differential diagnosis of hypotonia in a neonate, offers diagnostic and management recommendations, and discusses the final diagnosis.
AssuntosAcil-CoA Desidrogenase de Cadeia Longa/deficiência , Síndrome Congênita de Insuficiência da Medula Óssea/diagnóstico , Letargia/etiologia , Erros Inatos do Metabolismo Lipídico/diagnóstico , Doenças Mitocondriais/diagnóstico , Hipotonia Muscular/etiologia , Doenças Musculares/diagnóstico , Síndrome Congênita de Insuficiência da Medula Óssea/terapia , Diagnóstico Diferencial , Humanos , Hipotermia/etiologia , Recém-Nascido , Erros Inatos do Metabolismo Lipídico/terapia , Masculino , Doenças Mitocondriais/terapia , Doenças Musculares/terapia
Sitosterolemia or phytosterolemia is a rare autosomal recessive hereditary lipid storage disorder. It is caused by homozygous or compound heterozygous mutations in one of the two ABCG5 and ABCG8 genes encoding the intestinal and hepatic heterodimer ABCG5 (sterolin 1)/ABCG8 (sterolin 2) efflux transporters. These mutations lead to intestinal hyperabsorption and reduced hepatic secretion of cholesterol and plant sterols with subsequent accumulation of phytosterols and cholesterol in plasma and deposition in tissue (xanthoma). Phytosterols are found mainly in vegetable oils, margarine, nuts, grains, soybeans and avocados. Patients with sitosterolemia show extreme phenotypic heterogeneity from almost asymptomatic individuals to those with combined severe hypercholesterolemia at a young age, leading to increased atherosclerosis and premature cardiac death. Early abnormalities include hemolytic anemia with stomatocytosis, macrothrombocytopenia and splenomegaly. In addition to strict avoidance of phytosterol-containing foods, the use of the sterol absorption inhibitor ezetimibe, possibly in combination with the bile acid-binding resin cholestyramine, is the most effective treatment option.


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The show will be paused. At least, that's the message coming from leaders and artists in the music business as part of a movement being referred to as Blackout Tuesday.
Music executives Jamila Thomas and Brianna Agyemang spearheaded the effort to shutter normal business operations on June 2 via their #theshowmustbepaused initiative.
A Twitter account tied to the group appears to have been created on Sunday, amid a weekend that saw communities across the country protesting the murders of George Floyd and others at the hands of police.
Rihanna fans are falling for her take of a Selena Gomez song. Pop Crave reportedly leaked Rihanna's demo of "Same Old Love," a song that the 32-year-old singer was thinking about releasing on her own.
One year before Gomez, 27, released the track in 2015, Rihanna teased Twitter with a lyric from the song, suggesting that her version of "Same Old Love" was in the works. That tweet may have just been a coincidence, though, as Charli XCX later said that she, Mikkel Storleer Eriksen, Benny Blanco, Ross Golan, and Tor Erik Hermansen didn't write the song until 2015.
John Boyega has had enough.
The Star Wars actor flooded social media on Wednesday, speaking out about George Floyd's death two days after a Minneapolis police officer was filmed pinning the African American man to the ground with a knee on his neck.
"I really f---ing hate racists," Boyega tweeted on Wednesday. The post has since garnered over 1 million likes.
... read more
The Grammy Award-winning singer calls out the haters in a self-written and produced video clip that debuted during her 'Where Do We Go?' world tour.
Billie Eilish is letting the haters know that their negative opinions are not her responsibility.
On Wednesday, the singer released a short film in which she slowly undresses while her own voiceover slams those who are quick to body shame and pass judgement. Titled Not My Responsibility and written and produced by Eilish, the video, which originally debuted during the singer's Where Do We Go? world tour, shows the teen Grammy winner, remove an oversized hoodie, tantalizingly slowly, before slipping off a button-down shirt and eventually a tank top too. She then submerges herself fully in water. "Do you know me, really know me?" she asks in the voiceover. "You'll have opinions about my opinions, about my music, about my clothes, about my body."
Rihanna's debut single, "Pon de Replay," was released 15 years ago. On Sunday night (May 24), the singer joined the celebration of the song's anniversary on social media, where #15YearsOfRihanna trended.
"Thank you for all the love on this hashtag today! Man this is trippy," Rihanna wrote in an Instagram story. "Feels like just yesterday I was shaking in the hallways of Def Jam waiting to audition for Jay."
"Pon de Replay is where it all began....15 years later and I'm here because God led me to you, and you guys have held me up, supported me, tolerated me, loved me, kept it too real with me, and we gon always be connected because of that!" she said of the song, which dropped on May 24, 2005 and was included on her first studio album, Music of the Sun
You'll have to wait a little bit longer for more Gossip Girl.
HBO Max's eagerly-anticipated reboot of the CW show will not arrive until 2021, as production has been delayed due to the coronavirus pandemic. The series was scheduled to begin filming in March, which is about the time everything in Hollywood started to shut down.
"They hadn't even started production yet; they were in pre-production and ready to roll," HBO Max chief content officer Kevin Reilly told Vulture, which first reported the news. "Things that would have been really meaningful and high profile have gotten pushed back," he added.
Lana Del Rey has defended herself against accusations of racism, arising from a statement she made about double standards in the music industry.
In a long Instagram post this week the singer claimed she had been depicted as anti-feminist, despite singing about similar themes as other female artists.
But some fans remarked the examples she chose - among them Nicki Minaj and Beyoncé - were mainly black women.
"We Rise" is just the song we need right now and Romeich executed its delivery flawlessly.
What started as an initiative by music executive and entrepreneur Romeich to help out a few families has turned into helping hundreds. He has now shifted focus to helping thousands by releasing a brand new compilation track and video to help spread the message that there is strength in numbers, even while maintaining social distancing protocols.
"We Rise" takes the same form as the 1980's tribute track "We Are the World," which featured some of the biggest names in music at the time. "We Rise" features some of the current juggernauts in the Jamaican music fraternity, with many of the stars emerging from the Romeich Entertainment camp. TeeJay, Kash, Shenseea, Kemar Highcon, Ding Dong, Konshens, and Tarrus Riley all lend their voices to the uplifting track.
According to Billboard, Doja Cat and The Weeknd are about to release a special quarantine remix
On Tuesday (May 19), Doja put up a cheeky Twitter poll with The Weeknd listed as one of the possible collaborators on phony songs with titles including "Stuart Little," "Gumby" and "Pi--y T--s."
"Which one of these artists have I collaborated with and will be releasing the song to very soon?" she asked. A short time later she tweeted simply, "in your eyes," as well as changing her Twitter handle to the name of the song from Weeknd's recent After Hours album.


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Gallia Co Virtural Non Livestock Pre Fair Judging
Flipgrid. See link to Help Sheet. https://gallia.osu.edu/sites/gallia/files/imce/Program_Pages ... /4H/Fair/Forms/combind%20flip%20grid%20info..pdf Due by July 25th. ...
Food Preservation
just one or all of them. 1. The Ohio State University Extension Food Preservation Team will be hosting ... Are you ready to learn about food preservation? Have questions? We may not be able to meet in ... Overview of Food Preservation Methods June 12 Water-bath Canning June 19 ...
CFAP Direct Support sign up begins May 26
Farm Office team will also host a webinar about Ohio's CFAP sign up process soon. Be sure to ... By:Peggy Kirk Hall, Associate Professor, Agricultural & Resource Law Wednesday, May 20th, 2020 ... Coronavirus Food Assistance Program (CFAP). Those details finally arrived yesterday, when the USDA announced ...
Sue Hogan: National Excellence in Urban 4-H Programming Award Winner
a part of positive youth development. First generation 4-H youth can become engaged in the program ... Urban 4-H Programming award. The award is presented by National Association of Extension 4-H Agents. Sue ... regardless of barriers that might prevent them from doing so. This is achieved by conducting the program at ...
RESTART Ohio: Back to Healthy
Join Ohio State University Extension, Family and Consumer Sciences educators this summer for ... a fun, educational, and free new learning series! RESTART Ohio: Back to Healthy is a great opportunity to ... Ohio: Back to Healthy is not only an opportunity to learn something new this summer, it's also an ...
CHAIRE Inaugural Research Symposium
holding events in the future, Co-Directors Dr. Kelly George and Dr. Tony Parker and Program Coordinator ... species and presentation style. Each also fall into at least one of CHAIRE's focus areas which are Welfare ... Channel. Beginning on Wednesday 5/27-6/12 CHAIRE is also featuring one presentation per day on their ...
Animal Sciences Students Successful in 2020 American Dairy Science Association Virtual Annual Meeting
program consisted of over 800 abstract presentations (poster and oral), panel and roundtable discussions, ... an exhibit hall, and student competitions featuring more than 100 hours of programming. Award ... M.S. Division. Nicole is studying the development of the mammary vasculature in calves. Erin ...
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food preservation methods in a virtual format. Please see our county events page for program dates- ... Ohio State University Extension Family and Consumer Sciences' home food preservation ... Register Here Home Food Preservation Programs Hands on program offer a unqiue learning expirence. Due to ...
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NYPD to Continue Providing SROs; LAUSD Cuts Police Budget By $25 Million
Approximately $300 million of a $1 billion budget cut to the NYPD was supposed to be used to move SROs from under the agency.
Approximately $300 million of a $1 billion budget cut to the NYPD was supposed to be used to move SROs from under the agency.
Chief Jeff Godown agrees with the decision, stating 70% of calls his department receives should be handled by behavorial health specialists or counselors.
This two-day event will cover topics concerning lessons learned from COVID-19 and issues related to the re-opening of campuses.
The district's superintendent has been on paid administrative leave since he refused to honor a school board vote to demote two employees.
The push for removing police from schools and diverting funds toward social supports for students has gained traction following the killing of George Floyd.
Mayor Bill de Blasio said although he is not prepared to eliminate NYPD presence from schools, he is looking into supplementary "grassroots" alternatives.
Over two-fifths also need to update or replace heating, ventilation and air condition systems, raising concerns about reopening schools amid the coronavirus pandemic.
After parents filed a complaint, the Department of Justice surveyed 12 playgrounds and found more than 200 adjustments that needed to be made to comply.
The New York governor said he hasn't determined if children in the state will return to school in the fall, partially because of the unknowns of the disease.
Approved Whitehouse ISD staff will have to complete 80 hours of training and are required to pass physical and psychological exams.
How to choose a secure and user friendly access control system that aligns with student expectations
Crisis response can be a weak spot for many campuses. Learn how to manage tasks, share response plans and maintain command and control over response teams during a crisis.


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An 80-year-old Australian woman spent nine days in a coma before dying after her cat licked her wounds, causing bacterial…Read More »
If you have once cursed shopkeepers in the supermarket and thought, how hard can it be to keep 1.5m away,…Read More »
China wants to ban the eating of dogs and cats. The Ministry of Agriculture yesterday published a proposal for a…Read More »
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A 6-year-old sphynx (Canadian naked cat) from the Swiss town of Rüti, just south of Zurich, has quickly become one…Read More »
In Japan, they are local celebrities, the two cats who have been trying almost every day. Since mid-2016 to enter…Read More »
Although the name suggests otherwise, a catwalk is not the perfect place to bump into a cat. Yet that is…Read More »
Snapchat launches a series of filters that can make a selfie with your cat. The filters recognize the snout of…Read More »


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ageLOC® Nutriol Scalp & Hair Shampoo Reviews
Nu Skin® ageLOC® Nutriol Scalp & Hair Shampoo is a shampoo that provides optimal nourishment to support healthy, visibly full hair. A scalp and hair loving protein blend revitalises the scalp and promotes the appearance of stronger, thicker, healthier hair that resists breaking. Vitamin E and other antioxidants protect the scalp from free radicals, while BCA protects hair from heat and makes it appear smoother, shinier, softer and more manageable. A hair conditioning blend also promotes soft, silky and lustrous hair.
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Elinchrom Carrying Case Small Rotalux
This product is either directly despatched from our supplier or is produced to order. Whilst we will pre authorise your credit or debit card at the point of ordering, no payment will be taken for this item until we have contacted you to confirm that we are in a position to despatch the product. If you require further information we recommend that you contact one of our Customer Service representatives on 01603 486413.
A small bag for the following Rotalux softboxes: 60 x 80, 70 x 70, 90 x 35, 100 Octa, 70 Octa. More
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Delta will retire all Boeing 777 aircraft due to coronavirus
"We're making strategic, cost-effective changes to our fleet to respond to the impact of the COVID-19 pandemic."
(KMOX) - Delta plans to retire its 18 widebody Boeing 777s by the end of 2020 as a result of the COVID-19 pandemic. The decision is viewed as a sign that the airline doesn't expect a quick return of long-haul international travel.
A staff memo from Delta CEO Ed Bastian was shared on Twitter:
Delta CEO on retiring 777s pic.twitter.com/5O0dfSewiX— davidshepardson (@davidshepardson) May 14, 2020
"With international travel expected to return slowly, we've also made the difficult decision to permanently retire our Boeing 777 fleet – 18 aircraft – by the end of the year," Bastian stated in the memo. "Retiring a fleet as iconic as the 777 is not an easy decision – I know it has a direct impact on many of you who fly, crew and service these jets."
He states more "fuel-efficient and cost-effective" A330s and A350-900 planes, made by Airbus will be used in place of the Boeing jets.
Related: Eerie footage shows hundreds of planes parked in desert amid coronavirus cancellations
Airlines have grounded 16,000 planes — nearly two-thirds of the world's fleet — and they are delaying deliveries of jets that they agreed to buy before the pandemic, according to a report by the Associated Press.
The report says, air travel in the U.S. is down more than 90% from a year ago, and global traffic has seen a similar plunge.
The airline says it has parked more than 650 mainline and regional aircraft to adjust capacity to match reduced customer demand amid the pandemic
"We're making strategic, cost-effective changes to our fleet to respond to the impact of the COVID-19 pandemic while also ensuring Delta is well-positioned for the recovery on the backside of the crisis," said Gil West, Delta's Chief Operating Officer.
More specific details of the timing of the 777's exit from the fleet will be disclosed at a later date.
© 2020 KMOX (Entercom). All rights reserved


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Clean, Hendrick Affordable. REDUCED FROM $16,498!, EPA 26 MPG Hwy/19 MPG City!, $1,100 below NADA Retail! Heated Leather Seats, Back-Up Camera, Satellite Radio, iPod/MP3 Input, 4x4, TRANSMISSION: 9-SPEED 948TE AUTOMATIC... Aluminum WheelsKEY FEATURES INCLUDELeather Seats, 4x4, Back-Up Camera, Satellite Radio, iPod/MP3 Input. Rear Spoiler, MP3 Player, Keyless Entry, Privacy Glass, Steering Wheel Controls.OPTION PACKAGESENGINE: 3.2L V6 24V VVT Pentastar, 50 State Emissions, 3 Additional Gallons Of Gas, Dual Bright Exhaust Tips, Stop-Start Multiple VSM System, 3.25 Axle Ratio, LEATHER INTERIOR GROUP Heated Steering Wheel, Power 8-Way Driver Seat, Heated Front Seats, Power 4-Way Driver Lumbar Adjust, TRANSMISSION: 9-SPEED 948TE AUTOMATIC 2 SPEED PTU (STD). Jeep Trailhawk with Bright White Clearcoat exterior and Black interior features a V6 Cylinder Engine with 271 HP at 6500 RPM*. Get EPIC Fuel Economy! Save at the pump and drive even further between fill-ups! Aggressive PriceEXPERTS ARE SAYINGEdmunds.com's review says The Cherokee is exceptionally quiet at highway speeds. And over rough city streets, the Cherokee offers about as cushy a ride as you'll get in this class.. Great Gas Mileage: 26 MPG Hwy.AFFORDABILITYWas $16,498. This Cherokee is priced $1,100 below NADA Retail.BUY WITH CONFIDENCE3-month/3,000 Mile Limited Powertrain Warranty, 24/7 Roadside Assistance, Rental Coverage: up to 3 days at $30 per day not to exceed $90 per occurrence, Trip Interruption Service: hotel, transportation, meal reimbursement, Multi-point Vehicle Inspection; detail mechanical inspection, CARFAX Vehicle History ReportThe closing fee charged by Hendrick Toyota North Charleston, 7151 Rivers Avenue, Charleston, SC 29406 will not exceed $499.00 prior to January 1, 2021.This Dealership checks the vehicle recall status prior to making any pre-owned vehicle available for sale. Manufacturers and/or NHTSA may announce additional recalls at any time. To inquire about the recall status of this vehicle, visit: https://vinrcl.safercar.gov/vin/
Rick Hendrick Chevrolet Norfolk is the #1 destination for Chevrolet customers because of its commitment to getting the best deal for every customer. Our dealership is a market leader for the East Coast and is part of the Hendrick Automotive Group, one of the largest dealership groups in the country.
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† Based on 2015 EPA mileage ratings. Use for comparison purposes only. Your actual mileage will vary depending on how you drive and maintain your vehicle.
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6252 E. Virginia Beach Blvd • Norfolk, VA 23502Get Directions
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