text:
Are stem cells really the key to making humans live longer? – Wired.co.uk
Posted: February 16, 2020 at 1:45 am
To some longevity acolytes, stem cells promise the secret to eternal youth. For a hefty fee, you can pay a startup to extract your own stem cells and cryogenically freeze them, in the hope that they can one day be used in a treatment to help extend your life.
Other firms let you bank stem cells from your babys umbilical cord and placenta after childbirth, if youre convinced the high cost represents an insurance policy against future illness. Or you can follow the example of Sandra Bullock and Cate Blanchett and opt for an anti-ageing cream made with stem cells derived from the severed foreskins of newborn babies in South Korea.
Stem cells are the parent cells which give rise to other cells in our bodies. Since scientists first isolated human embryonic stem cells in a lab and grew them over 20 years ago, they have been mooted as a source of great hope for regenerative medical treatments, including for age-related degenerative conditions such as Parkinsons, Alzheimers, heart disease and stroke.
But apart from a few small-scale examples, the only stem cell-based medical treatment practised in clinics uses haematopoietic stem cells found in the blood and bone marrow which only produce blood cells for transplants in blood cancer patients. These cells are taken from a patients sibling or an unrelated donor, before being infused into a patients blood, or theyre taken from a patients own blood before being reinfused. The procedure has been used to treat blood malignancies for almost half a century, and recently multiple sclerosis too. So how likely is it that the predictions about stem cells' longevity-enhancing powers will become a reality?
In September 2019, Google banned ads for unproven or experimental medical techniques such as most stem cell therapy, citing a rise in bad actors attempting to take advantage of individuals by offering untested, deceptive treatments [that can often] lead to dangerous health outcomes. The decision was welcomed by the International Society for Stem Cell Research, which emphasised that most stem cell interventions remain experimental. Selling treatments before well-regulated clinical trials have been done, the body said, [threatens public] confidence in biomedical research and undermines the development of legitimate new therapies.
Its easy to see how less scrupulous companies can exploit the allure of stem cells, which seem to occupy a place in our collective consciousness as a kind of magical elixir. High hopes for stem cell-based therapies have grown since 2006, when the Japanese biologist Shinya Yamanaka created a new technology to reprogram adult cells, such as skin cells, into a similar state to embryonic stem cells, which are pluripotent, meaning they can develop into any tissue in the body. The Nobel prize-winning breakthrough was hailed as a major step in the study of stem cells without the need for controversial embryo research, and towards the use of these human induced pluripotent stem cells to regenerate damaged or diseased organs or effectively grow new spare parts which could treat the life-limiting and life-shortening illnesses associated with ageing.
Gerontologist Aubrey de Grey, whose Strategies for Engineered Negligible Senescence (SENS) research foundation aims to eliminate ageing-related diseases, thinks the chances well soon have stem cell based therapies are high. For anything that's in clinical trials, you're talking about maybe five years before it's available to the general public, he says, citing stem cell treatments for Parkinsons disease, currently being tested in phase two clinical trials, as one of the developments he thinks is likely to come soonest.
However, given that these trials involve a relatively small number of participants and most clinical trials ultimately fail, his predictions might be overly optimistic. Often described as a maverick, De Grey believes that humans can live forever and there is a 50 per cent chance medical advances of which stem cell therapies will play an important part will make this a reality within the next 17 years. Though living forever, he says, is not the ultimate goal but a rather large side effect of medicine which will successfully prevent or repair the damage that comes with ageing.
For New Jersey-based Robert Hariri, who co-founded Human Longevity Inc, which set its sights more modestly on making 100 the new 60, stem cells derived from placentas present especially exciting opportunities. A biomedical scientist, surgeon and entrepreneur, Hariri says his current venture Celularity which is focused on engineering placental cells, including stem cells, to create drugs for cancer and other conditions is not as concerned about the actual age number, but about preserving human performance as we age and treating the degenerative diseases that rob us of our quality of life.
Many of those working in the field, however, remain cautious in their optimism. Researchers have highlighted the potential risks of giving pluripotent cells to patients, whether they are induced or embryonic, as these cells can develop cancer-causing mutations as they grow.
Davide Danovi, a scientist at Kings College Londons Centre for Stem Cells & Regenerative Medicine, says the path to stem cell-based therapy is very long and full of hurdles. The supply chain involves challenges, he says. On the one hand, allogeneic treatments those with stem cells derived from one individual and expanded into big batches to create cells to treat many individuals have the advantage of being similar to the traditional pharmaceutical business models. The product is clear, its something that comes in a vial and can be scaled up and mass produced, Danovi says. But this treatment can present a greater risk of rejection from the patient, as opposed to the more bespoke autologous option which is more expensive and time-consuming as it involves extracting a patients own stem cells before reprogramming them.
Danovi is most excited by the potential of stem cells to treat age-related macular degeneration. In 2017 Japanese scientist Masayo Takahash led a team that administered transplants of artificially grown retinal cells created from induced pluripotent stem cells taken from donors to five patients with the eye condition, which can cause blindness, and theyre reported to be doing well. The eye, he says seems to be a place where immunity plays less of a role relative to other issues, so you can host cells which come from another individual with fewer problems [of rejection]. But, with other organs such as the liver, he says there are major conceptual problems with creating enough tissue. Its like the clean meat burger - you're talking about a production that is, in many cases, not easy to reach with the current technology.
Hariri believes placentas will solve some of the production challenges crucially, theyre an abundant commodity, with the vast majority thrown out after childbirth. His interest was sparked 20 years ago when his oldest daughter was in the womb: When I saw her first ultrasound in the first trimester, the placenta had already developed into a relatively sizable organ, even though she was just a peanut-sized embryo. Id been taught that the placenta was nothing more than an interface, but [if that was the case], you would expect that it would grow at the same rate as the embryo. His curiosity piqued, he began to see the placenta not as an interface but as a biological factory, where stem cells could be expanded and differentiated to participate in the development of that foetus. That intrigued me and I started to collect placentas and just, you know, basically disassemble them.
Placentas have numerous benefits, he says they dont carry the same ethical controversy as embryonic stem cells, for one thing. Scientists working on embryonic stem cells have to destroy an early embryo, and that option yields them a dozen cells, which have to be culture-expanded in the laboratory into billions of cells. In contrast, the placenta houses, billions and hundreds of billions of cells, which can be expanded as well, but you're starting out with a dramatically larger starting material.
Increasingly, scientists in the anti-ageing sphere are focusing on an approach that seems like the opposite of planting fresh stem cells into our bodies. Experts such as Ilaria Bellantuono at Sheffield Universitys Healthy Lifespan Institute are working towards creating senolytics medication that could kill off our senescent cells, the zombie cells that accumulate in tissues as we age and cause chronic inflammation. I think stem cells are very good for specific disease, where the environment is still young, Bellantuono says, but the data in animal models tells us that senolytics are actually able to delay the onset and reduce the severity of multiple diseases at the same time for example, there is evidence for osteoarthritis, osteoporosis, cardiovascular disease, Alzheimer's, Parkinson's, and diabetes. She explains that while human trials are still in their early stages, senolytics are likely to be more cost-effective than stem cell therapy and the status quo of older patients taking multiple pills for multiple diseases, which can interact with each other. Besides, she adds, they may actually work in tandem with stem-cell based therapies in the future, with senolytics creating a more hospitable environment in tissues to allow stem cells to do their work.
And as for the so-called penis facial? Its far from the only ultra-expensive stem cell skincare making bold anti-ageing claims but youre probably better off saving your money, as you are with the experimental medical treatments on offer. Stem cells are definitely exciting but theyre not the key to eternal youth. At least, not yet.
Robert Harari will be one of the speakers at WIRED Health in London on March 25, 2020. For more details, and to book your ticket, click here
Why do modern tomatoes taste so bad?
How Tesla became the world's most overvalued car company
Marvel at the incredible real-life Iron Man
How Slack ruined work
Follow WIRED on Twitter, Instagram, Facebook and LinkedIn
Get The Email from WIRED, your no-nonsense briefing on all the biggest stories in technology, business and science. In your inbox every weekday at 12pm sharp.
by entering your email address, you agree to our privacy policy
Thank You. You have successfully subscribed to our newsletter. You will hear from us shortly.
Sorry, you have entered an invalid email. Please refresh and try again.
See the article here:
Are stem cells really the key to making humans live longer? - Wired.co.uk
- RenovaCare Appoints Dr. Lydia M. Evans to Its Board of Directors and Increases Board Membership - Stockhouse - August 6th, 2020
- RenovaCare Appoints Dr. Lydia M. Evans to Its Board of Directors and Increases Board Membership - GlobeNewswire - August 5th, 2020
- The best anti aging skin care products to use in your 40s - TODAY - August 5th, 2020
- Demand for Medical Skin Care Products Market Driven by Shifting Consumer Perceptions and Growing Awareness - Market Research Vista - August 5th, 2020
- Pediatrics in Brevard: Nothing beats the benefits of breastmilk for newborns - Florida Today - August 5th, 2020
- Biotechnology Could Change the Cattle Industry. Will it Succeed? - Undark Magazine - August 5th, 2020
- How to exfoliate your face and body properly, according to a dermatologist - Insider - INSIDER - August 2nd, 2020
- T cells, B cells and the range of the human bodys immune response A simple decoder - ThePrint - August 2nd, 2020
- Readers ask about antibody tests, chimeras and public health and privacy - Finance Brokerage - August 2nd, 2020
- The Best Sugar Body Scrubs That You Can Buy on Amazon - STYLECASTER - July 31st, 2020
- Regenerative Medicine Market 2020 | Research Objectives and Methodology, Growth Analysis, Top Manufacturers Sales, and Cost Structures Forecast 2024 -... - July 31st, 2020
- BEAUTYFLUFF, a rising skin care line, has launched a new eye and lip product in the midst of a pandemic. - Your Digital Wall - July 31st, 2020
- Exosome Therapeutic Market 2020 : Industry Size & Share, Business Strategies, Growth Analysis By EXOCOBIO, Exopharm, AEGLE Therapeutics, United... - July 31st, 2020
- Anti-Ageing Drugs Market 2020: Worldwide Overview And Forecast To 2023 With Regional Trends And Comp - PharmiWeb.com - July 31st, 2020
- Rethinking the Science of Skin - The New Yorker - July 30th, 2020
- The function of the thymus and its impact on modern medicine - Science - July 30th, 2020
- Bring the Salon Home: Skin Care Tips from North Shore Estheticians - nshoremag.com - July 30th, 2020
- Advances in Treating Non-Small Cell Lung Cancer - GlobeNewswire - July 30th, 2020
- A breakthrough: Stem cell therapy cures Covid-19 The Manila Times - The Manila Times - July 30th, 2020
- Flower Power: The Benefits of 6 Key Floral Extracts in Skin Care - NewBeauty Magazine - July 30th, 2020
- Global Stem Cell Reconstructive Market- Industry Analysis and Forecast (2020-2027)-by Sources, Cell Type, Application, End User and Region. - Red... - July 30th, 2020
- Medicine The rise of the pores and skin on rooster meat has been thought of for the reason that 19th century: It has now change into clear {that a}... - July 30th, 2020
- Skin Care Cosmetic Market 2026 | Procter & Gamble Avon Products Inc L'Oreal SA Unilever PLC Beiersdorf AG The Body Shop International PLC ... - July 30th, 2020
- 10 refreshing, cooling beauty products that are all natural - Yahoo Sport UK - July 30th, 2020
- Science May Have Finally Explained The Reason Why We Still Get Goosebumps - ScienceAlert - July 26th, 2020
- Charles Darwin Investigated Goosebumps Now Harvard Scientists Discover the Real Reason Behind Them - SciTechDaily - July 26th, 2020
- Finally, the health riddle weve all been puzzled by: Why we get goosebumps - The New Daily - July 26th, 2020
- Study finds the real reason you get goosebumps - Big Think - July 26th, 2020
- Revenue from the Sales of Amniotic Fluid Stem Cell Therapy Market to Increase Exponentially During 2018 2026 - Owned - July 26th, 2020
- 12 Best Natural and Organic Foundations of 2020 That Don't Crease - Cosmopolitan - July 26th, 2020
- Regenerative Medicine Market Projected Growth Rate 2020 | Demand Status, Future Scope, Upcoming Trends of Manufacturers, Global Share with Industry... - July 26th, 2020
- Dream of Plentiful Organ Transplants Moves Closer to Reality as Scientists Grow Tiny Working Livers from Skin Cells - Good News Network - July 8th, 2020
- Stem Cell Therapy Market Segmentation Detailed Study with Forecast to 2025 - Owned - July 8th, 2020
- Impact Of COVID-19 On Skin Care Cosmetic Market 2020 Industry Challenges, Business Overview And Forecast Research Study 2024 - Owned - July 8th, 2020
- Ive Been an Esthetician for 30 YearsThis Is What I Do to My Skin Every Single Night - Well+Good - July 8th, 2020
- Feliciano receives $667K DOD grant to explore developmental disorder that causes tumors in the body and brain - Clemson Newsstand - July 8th, 2020
- One common infection could kill our baby girl but one simple act could change her life forever - The Sun - July 8th, 2020
- History made as first person ever is 'cured' of HIV using medication alone - PinkNews - July 8th, 2020
- What is lymphoma? Symptoms, causes and diagnosis - Yahoo Lifestyle UK - July 8th, 2020
- Global Cosmetic Skin Care Market Updates, Future Growth, Business Prospects, Forthcoming Developments by Forecast to 2026 - 3rd Watch News - July 8th, 2020
- Seed to Skin - Gulfshore Life - July 3rd, 2020
- What if mammoths are brought back from extinction? - The Economist - July 3rd, 2020
- Is Laser Hair Removal Worth the Cost and Hassle? What to Know - Glamour - June 30th, 2020
- Breast Implants Market Growth Opportunities Created by Covid19 Outbreak - Cole of Duty - June 30th, 2020
- COVID-19: Plasma therapy vs stem cell therapy, what's the difference? - Gulf News - June 29th, 2020
- Autologous Stem Cell and Non-Stem Cell Based Therapies Market 2020: Challenges, Growth, Types, Applications, Revenue, Insights, Growth Analysis,... - June 29th, 2020
- Amniotic Membrane Market by Product, Application and Forecast to 2027 TMR - 3rd Watch News - June 29th, 2020
- SFARI | SFARI workshop explores challenges and opportunities of gene therapies for autism spectrum disorder - SFARI News - June 29th, 2020
- Surrozen reloads with $50M for final dash to the clinic, shines some light on lead Wnt-modulating candidates - Endpoints News - June 29th, 2020
- Breastfeeding 'even better than previously thought' - The Irish News - The Irish News - June 29th, 2020
- Breastfeeding and COVID-19 - World Health Organization - June 28th, 2020
- Top 10 Best Cream Serum With Vitamin Es 2020 - Best gaming pro - June 28th, 2020
- Skincare Brands To Try Out This Summer - GirlTalkHQ - June 28th, 2020
- Best Hair Growth Tips: 5 Food Items to Include in Your Daily Diet For Long And Strong Tresses - India.com - June 28th, 2020
- Professor: Looming COVID Surge on "Verge of Being Apocalyptic" - Futurism - June 28th, 2020
- Mini-Organ Research Reveals What COVID-19 Does to the Body - Futurism - June 27th, 2020
- The Future of Skin Care Hinges on Keeping Time With Your Complexions Natural Rhythm - Well+Good - June 22nd, 2020
- Global Amniotic Fluid Stem Cell Therapy Market Revenue to Record Stable Growth Through 2026 - Cole of Duty - June 22nd, 2020
- Serena Williams reveals her skincare regimen - HOLA USA - June 22nd, 2020
- Rapid Unit Sales of Oncology Drugs to Account for Incremental Revenues in the Global Market - Cole of Duty - June 22nd, 2020
- Signs the Skin Is Ageing Prematurely - News Anyway - June 18th, 2020
- New Harris Poll Survey Shows 60% of Women Surveyed Feel It's Their Fault They Have Cellulite - PR Newswire UK - June 18th, 2020
- 'Sara Hegazy was jailed and tortured for a photo. It could have been me.' - Mamamia - June 18th, 2020
- Westerleigh resident is alive because of stem cell therapy by his doctor -- for free. Heres his story. - SILive.com - June 14th, 2020
- Sure, Bit Bio got some significant cash for its cell coding work. But it's the insiders who are backing them that will garner the attention -... - June 14th, 2020
- 4 Neck Creams Dermatologists Swear By To Get Rid Of Wrinkles And Sagging Skin - SheFinds - June 14th, 2020
- Poison hemlock and wild parsnip, A couple of bad actors - Commonwealth Journal's History - June 14th, 2020
- Irish dad with rare form of cancer would have died within a week if he didn't go to hospital - Irish Mirror - June 14th, 2020
- Vitamin C Face Serum - Triple Strength Anti Aging, Wrinkle & Brightening Facial Care - Antioxidant Rich, Hydrating, Softening & Even Skin Tone... - June 14th, 2020
- Skin Toner Market 2020: Analysis Of Sales, Overview, Segmentation And Growth Rate To 2027 - 3rd Watch News - June 12th, 2020
- Microneedling therapeutic stem cells into damaged tissues - PRNewswire - June 11th, 2020
- Major skin cancer research study to begin at The Hormel Institute - Austin Daily Herald - Austin Herald - June 11th, 2020
- Exploring the Therapeutic Potential of ST266 Against Numerous Diseases Including COVID-19 - Technology Networks - June 11th, 2020
- 'I found these 4 affordable winter skin saviours in the chemist beauty aisles.' - Mamamia - June 11th, 2020
- Rapid Unit Sales of Oncology Drugs to Account for Incremental Revenues in the Global Market - Medic Insider - June 11th, 2020
- Ability to 'Create' Astrocytes Supports Their Damaging Role in MS... - Multiple Sclerosis News Today - June 5th, 2020
- Photoaged Skin Therapy with Adipose-Derived Stem Cells - MedicalResearch.com - June 5th, 2020
- Eradicating balding a step closer with new procedure in the cross hairs - The New Daily - June 5th, 2020
- Follica Announces Positive Feedback From End of Phase 2 Meeting With FDA for Its Lead Program to Treat Male Androgenetic Alopecia - BioSpace - June 5th, 2020
- Hope Realized - CU Anschutz Today - June 5th, 2020


text:
Communications Associate
Reporting to the vice president, communications, marketing and advocacy, the communications associate plays a key role in engaging stakeholders both internally and beyond our walls to tell the extraordinary story of Holland Bloorview and advance our No Boundaries strategic plan. The position holder will coordinate day-to-day communications requests across the hospital, leverage hospital accomplishments for external purposes, oversee communications projects and develop on-brand communications materials. The position holder will also provide strategic communications support to internal departments and work with teams to develop digital and design content. The associate will have an opportunity to use their diverse skill set to contribute to corporate awards submissions, conference sponsorship fulfillment, partner/community relations, media relations support and website updates.
The successful candidate will have demonstrated experience coordinating communication activity in a multi-stakeholder environment as well as and experience collaborating with a variety of internal and external partners. The position holder will work closely with all members of the communications and public engagement team and staff from across the organization. This is an opportunity to join a unique, high-performing team that is comprised of both hospital and Holland Bloorview Foundation colleagues that works together to create acceptance of childhood disability, awareness and philanthropy in support of Holland Bloorview.
- Support the communications and public engagement team in working with hospital colleagues to create marketing and communications materials that can be leveraged for external use
- Support internal departments with strategic communication advice and the development of marketing collateral.
- Use writing talent to craft compelling copy for use in internal newsletters and website.
- Coordinate internal communication tools including weekly all-staff newsletter, pandemic bulletins and intranet requests.
- Project support including critical path development, work planning, measurement and evaluation
- Provide communication support on corporate initiatives including sitting on working groups, creating signage and drafting communiques to support Holland Bloorview's pandemic response
- Manage event logistics and the creation of communication materials for hospital events
- Coordinate with external partners on the promotion of partnered activities
- Support evaluaton and fulfillment processes related to sponsorship of external conferences and events
- Act as communications support for change management projects within the hospital
- Assist in the research and management of corporate awards submissions
- Working with hospital partners, update corporate website and intranet
- Support media relations outreach as needed
- Degree, diploma or post graduate certificate in public relations, communications or a related field
- Excellent written communications and editing skills, knowledge of CP style is an asset
- 2-3 years of experience in communications , ideally in a healthcare or not-for-profit setting
- Strong oral communications skills
- Ability to work with a variety of internal and external stakeholders including researchers, volunteers, staff and partners
- Team player, good judgement and ability to work independently as needed
- Ability to juggle multiple projects under tight timelines
- Understanding of the health care sector and childhood disability issues is an asset
- Experience working with content management systems (including MS SharePoint) and Adobe Creative Suite are considered an asset
- Intermediate skill with Microsoft Office 2010 suite
Holland Bloorview has won numerous awards including Greater Toronto's Top Employers, Canada's Top Employers for Young People and Canada's Most Admired Corporate Cultures. We offer an inspiring, innovative, and collaborative work environment with competitive compensation and benefit packages and programs that support ongoing learning and professional growth.
Holland Bloorview Kids Rehabilitation Hospital is a fully affiliated teaching hospital of the University of Toronto and is committed to fostering a climate of equity and diversity and welcomes and respects the diversity of our clients, families, staff, trainees, volunteers, trustees and partners. As part of our commitment to fair and equitable recruitment and selection practices, we encourage applications from racialized persons, women, Indigenous/Aboriginal People of North America, persons with disabilities, LGBTQ persons, and others who may contribute to the further diversification of ideas within our community.
Interested applicants are invited to submit their application by pressing the "Apply" button near the top of this page. Should you require accommodation during any stage in the recruitment process, please contact Human Resources at firstname.lastname@example.com or 416-425-6220.
This position is currently accepting applications.
Apply Now

subset: commoncrawl


text:
The world first bone conduction full wireless Earphone appearance
August 10, 2020
It is L-JUN.
No, ..., the rainy season were over!
Surpassing 30 degrees is very severe day after day,
Which does everybody like in winter in the summer?
We like me both!
Then this recommended product is this!
What this form is it? That you who thought of this!
This is world's first bone conduction full wireless Earphone boco PEACE TW-1!
It is Earphone to sandwich, and to use without putting in the ear.
When cannot hear, thing sounds like outside sound well, and can listen to music well; is superior, and is thing.
We actually employed me, but are surprised to hear well!
It was the first bone conduction full wireless Earphone, but is more than expected!
As we hear outside sound, we cease to miss announcement by commuting and attending school.
As omission of sound decreases, you do not need to mind around.
Sweat and sudden rain are fine with waterproofing performance of IPX7 class. We feel safe that this sweats by jogging and exercise even if we get wet with sudden rain.
There is little worry to come off as he/she sandwiches ear well.
People made telework increase recently. When we make video conferencing in house, we hear voice of the circumference and are convenient.
Please sense new MusicLife bodily so far in bone conduction full wireless Earphone which there was not, boco PEACE TW-1!
Recent article
Recent article
Furthermore, former article from this
Audio system diary which improves what member of audio system enthusiast felt including L-JUN, favorite thing at will.
For us, music is always over there.


text:
Chapter 8
The rain set the tone for the morning. Ally, already mourning their departure, was quiet when she came out of the bedroom and Ellie was bummed that it was raining and they couldn't go out.
Clive wasn't looking forward to packing up in the rain but Mrs. McAdams tried to put a positive spin on the circumstances by repeatedly singing 'Rain Rain Go Away, Come Again Some Other Day!" as she made waffles for the group.
Mrs. McAdams was all smiles toward Clive who couldn't help but feel humbled and bashful about last night's lovemaking but Mrs. McAdams (Elena?) was acting like a schoolgirl so he guessed everything was okay between them.
"Mom, why are you acting so happy?" Ellie protested. "It's raining and it's our last day."
"I'm happy because we're all together, Sweetie," Mrs. McAdams said, kissing the girl on the top of her head. "I'm happy because it's been the best vacation ever."
Ellie laughed. "Well, that's true," she said.
"Wouldn't you agree, Ally?" Clive asked knowingly.
"Yes," Ally admitted sadly. "It has been the best vacation ever. I wish it didn't have to end so soon."
Her mother took center stage in the middle of the kitchen and began to orate:
They sing their dearest songs—
He, she, all of them—yea,
Treble and tenor and bass.
And one to play;
With the candles mooning each face...
Ah, no; the years O!
How the sick leaves reel down in throngs!
They clear the creeping moss—
Elders and juniors-—aye,
Making the pathways neat
And the garden gay;
And they build a shady seat...
Ah, no; the years, the years;
See, the white storm-birds wing across!
They are blithely breakfasting all—
Men and maidens—yea,
Under the summer tree,
With a glimpse of the bay,
While pet fowl come to the knee...
Ah, no; the years O!
And the rotten rose is ripped from the wall.
They change to a high new house,
He, she, all of them—aye,
Clocks and carpets and chairs
On the lawn all day,
And brightest things that are theirs...
Ah, no; the years, the years;
Down their carved names the raindrop plows.
She finished reciting the poem and she looked at her two awestruck dumbfounded daughters, laughing at their reaction.
"That's Thomas Hardy's During Wind and Rain," Mrs. McAdams said with a smile. "I had to memorize it for a high school English class."
"You still remember it?" an impressed Ally asked.
"Oh, no, the years! The years!" Ellie cried melodramatically, placing her hand across her forehead and throwing her head back.
Clive laughed. "The years! The years!"
"It's not funny," Ally protested, trying to remain miserable but she couldn't help but laugh herself.
"You have to laugh during the wind and rain," Mrs. McAdams told them. "Don't let the weather ruin our day. It's been a good vacation."
"Thanks for letting me be the fourth," Clive said with affection and emotion.
"We're glad you came," Ally smiled.
They played a board game after breakfast and then sat on the porch and watched it rain while Mrs. McAdams stripped the beds and cleaned the kitchen and bathroom.
Clive went down to the dock and dragged the rowboat onto the shore, flipping it over, and he pulled the canoe back up the hill and returned it to its sawhorse mooring on the side of the cottage. He put the fishing pole and tackle box back on the porch and he dragged the trash to the barrels out behind the cottage.
Mrs. McAdams was standing in the kitchen screen door when he returned to the cottage.
"Was last night a one and done?" Clive asked.
"I hope not," Mrs. McAdams answered truthfully. "The girls like you. I like you."
"Won't I be too young for you when we get back to Greenville?" He worried.
"You're not as young and I'm not as old," Mrs. McAdams replied. "Let's see how it goes, okay?"
"Okay," Clive agreed as she stepped back and let him through the door.
Ally was sitting on a chair on the porch when Mrs. McAdams and Clive emerged from the cottage.
"Danny said they'd come say goodbye after church," Ally said sadly. "I told him we had to be out by noon like you said, Mom."
Clive took a chair next to her and leaned in close. "Make sure you get a kiss goodbye," he said quietly.
Ally blushed.
"Go for it if he doesn't," he advised.
"Clive!" She said with embarrassment.
"You don't want to regret the opportunity," he said. "You have his text and e-mail?"
"Get a kiss too," he said.
She looked at him and slowly a smile came across her face. "Keep floating?"
"Keep floating," he nodded.
The rain let up a little which allowed them to load up the minivan. All the chores were done and they were ready to leave, waiting only for the Davidsons to show up for the final farewell.
"Oh God," Ally said when she saw the Davidsons walking toward the cottage with umbrellas and goulashes. "This is it."
She left the porch first with Ellie and Clive following behind. Mrs. McAdams locked the door to the cottage and stepped out into the drizzle where the two families exchanged goodbyes and well wishes.
Ellie climbed into the car and Ally hesitated for a moment as she stood in front of Danny who awkwardly looked down at his feet.
"Hey Danny?" Ally asked.
"Yeah?" He said nervously as he lifted his head up to look at her.
"Goodbye," she smiled, leaning in and giving him a smooch right on the mouth.
Danny's eyes went wide and he turned to join his waiting family.
Ally started to get in the back of the van but Clive stopped her by taking hold of her arm. "Why don't you sit up front with your mother?" He said, not mistaking the water on her cheeks as tears instead of raindrops.
"Thanks, Clive," she said. "It will be nice to talk to her."
Ally got in the passenger seat and Clive joined Ellie in the backseat. The Davidsons stood by the side of the driveway under their umbrellas waving as Mrs. McAdams backed the van out of the drive.
"Oh, no, the years! The years!" Ellie cried melodramatically, placing her hand across her forehead and throwing her head back and the others laughed and cried at the same time as they left the lake.


text:
The National Working Committee of the All Progressives Congress (APC) has rejected the invitation extended to its members to attend the National Executive Committee meeting convened by Victor Giadom.
President Muhammadu Buhari had on Wednesday thrown his weight behind Victor Giadom, as the acting National Chairman of the party, a move the NWC said the presidentnwas ill advised and blackmailed into supporting illegality.
The NWC said this in a statement jointly signed by the Ag. National Chairman, Hilliard Eta, and Ag. National Secretary, Waziri Bulama, in Abuja, on Wednesday.
The statement read, "We wish to unequivocally state that members of the National Working Committee believe that the President was offered wrong advice or blackmailed into lending his weighty office to the illegality of the National Executive Committee meeting purportedly convened by one Victor Giadom on 25th June, 2020.
"We hereby respectfully implore Mr. President to kindly avail himself with facts of the matter regarding the impasse presently experienced by the Party so as to guide him in his assessment of the matter because we are sure that the President, if properly advised, would come to the conclusion that the meeting convened by Chief Victor Giadom bothers on illegality and criminality.
"The National Working Committee regrets to turn down the invitation to the illegal and unconstitutional National Executive Committee convened by Chief Victor Giadom.
"We believe that attending such a meeting will amount to embracing illegalities and turning a blind eye to the infractions on the Constitution of our great Party."


text:
Monday: God's Will: Holiness (1 Thess. 4:3)
First Thessalonians 4:3-8 forms a complete unit of thought. The will of God for each Thessalonian believer is "holiness" or "sanctification" (1 Thess. 4:3, 4, 7, ESV). What Paul means by holiness here is explained by two following clauses. Each believer is expected to "avoid sexual immorality" and to "control his own body" (1 Thess. 4:3, 4, NIV). Paul concludes the unit of … Continue reading –>


text:
Blue Diamond Oven Roasted Almonds, Dark Chocolate
- Oven Roasted
What other items do customers buy after viewing this item?
Customers who viewed this item also viewed
Have a question?
Find answers in product info, Q&As, reviews
Your question may be answered by sellers, manufacturers, or customers who purchased this item, who are all part of the Amazon community.
Please make sure that you are posting in the form of a question.
Please enter a question.
Product description
It's not easy to turn off your chocolate cravings & give up sweets. Now you don't have to. Our Dark Chocolate Oven-Roasted Almonds are covered in real cocoa powder & loaded with rich chocolate flavor, blended with just the right amount of sugar & naturally no-calorie stevia extract. By combining the creamy rich flavor of real dark chocolate with our almonds, packed with nutrition & naturally loaded with vitamin E, we turned a tough challenge into a delicious snack you can enjoy every day.
Product details
Would you like to tell us about a lower price?
Customer reviews
|5 star (0%)
|4 star (0%)
|3 star (0%)
|2 star (0%)
|1 star (0%)


text:
You don't need to destroy thousands of trees for DHA project
I ENCOURAGE Peter Sheridan (TC, 30/10) to visit the Mt Lofty DHA housing site in Martini St.
Does he really think he can advocate the retention basin development in Ballin and Garnet Lehmann Parks as a model for the Mt Lofty site?
From Martini St, he will be looking out over the last large greenfield site on the edge of the escarpment. It has a magnificent view over the Lockyer Valley.
It is completely different in several important ways from Ballin/Lehmann. Ballin/Lehmann remains open public space, not another 344-house suburb.
The Ballin/Lehmann development has not caused traffic chaos in the surrounding residential areas.
The Toowoomba Regional Council estimates that there will be an extra 3400-4000 car movements in and out of the Mt Lofty development every day.
Did the Ballin development dislodge a koala colony or interfere with satin bower birds and other wildlife in a natural forest adjoining thousands of hectares of pristine old growth forest?
Was Ballin used as a military weapons range for more than 100 years which caused major soil contamination?
The details of the DHA project show they have finally admitted that only 10-20 per cent of their houses will be occupied by military families. The rest of the houses and land are for commercial development to make money for the federal government.
The bottom line is that they could build 30-60 houses and a magnificent public park without destroying thousands of trees. That would be a great gift to the garden city.
STEPHEN JONES, Toowoomba


text:
Installing a bathroom in a basement costs more than installing a bathroom above ground. Costs can range from $2,500 to $5,000 on average, depending on the number of fixtures and whether the plumbing must be installed from scratch or if it's roughed in already. Basement plumbing requires special considerations to ensure proper drainage and tie-in with the main sewer line, which may not be deep enough to allow the basement bathroom plumbing to use gravity the way above-ground plumbing does. Virgil Miranda's Construction subcontracts all plumbing work. Miranda says that sometimes the toilet alone in a basement can cost up to $2,500 because sometimes homeowners need to invest in a toilet that does not use gravity but instead a macerating function to grind waste down to prevent clogging. Miranda estimates that each bathroom fixture in a basement costs $800–$900 on average, so a full, three-piece bath could cost $3,000 for the fixtures alone. Adding a kitchenette or wet bar sink adds more to overall refinishing costs. In addition, some basements require a French drain with one or more sump pumps, which can cost up to $10,000 on average, depending on how much ground the drain covers.
Great tips. At the onset of explaining various causes of a squeak, Tom Silva says it can be alignment, either of the door-to-hinge, or hinge-to-hinge. Hmm, seems to me those two scenarios different than the case in the vid, that being singular hinge with the barrels out of alignment. So, the vid shows a great solution to fixing out of alignment barrels, but what about fixing doors with hinges out of alignment from each other, or hinges out of alighment on the door? How do you make that determinations, and what is the solution? thx
Since this basement is not entirely underground - it includes a walk-out entrance on one side -- new egress windows bring natural light into the basement. A simple Roman shade in fun fabric softens the space and brings all the colors of the room together. Egress windows provide an emergency exit; most building codes require one in every bedroom and in habitable basements. Adding one will likely increase the value of a home, as it provides safety, natural light, and increased airflow.
A finished basement is not always the same thing as a designed basement. Sometimes, the basement begins with the basics: walls, a ceiling, lights, and a floor. Gwen Hefner and husband Micah wanted to turn their tiny, airless basement space into a comfortable mancave. They had the basics to start with. The next step, Gwen says, would be a true test to her design skills.
Before using this basement remodeling calculator, understand that its pricing is based on a few basic assumptions about your floor. The calculator is assuming that you're starting with a concrete floor in an unfinished basement. Anything beyond that, including removal of old flooring materials, is not taken into account in this estimate. You should keep this in mind.
Do it yourself (DIY) basement finishing costs mostly depend on the cost of materials used. Materials for a 1,200 sqft basement with a small kitchen and bathroom will cost about $19,000 for an open-plan and about $27,000 for one with rooms. DIY basement finishing can save at least 30% of your finishing cost, but you'll still have to pay for plumbing and electrical work.
According to real estate agents and appraisers, a bedroom must have a door, window and closet. Adding a closet to your basement bedroom is crucial to adding value to your basement addition. There are a few components that will affect the cost, the size of the closet being the biggest. The average cost to install a closet is $1,779, with most homeowners spending between $1,272 and $1,917. More than likely, your closet cost will be lower seeing that the size of the closet won't be nearly as large as your master bedroom or other main bedrooms.
How fast the job needs to be completed has a significant impact on the final price. A professional team can take a basement from framing to complete in about 45 days. A DIYer typically needs more time. If things need to be inspected, inspectors work on their own schedule, and if concrete needs to be poured, time must be allotted for it to properly set.
The ceiling of this Connecticut basement was very unattractive. Wire, pipes, and insulation were exposed to the room below. Connecticut Basement Systems recommends installing a drop ceiling when finishing basements. These allow easy access to shut off valves, wires, and pipes that lead to the rest of the home. The tiles of our drop ceilings are made of mineral wool, making them completely inorganic. Mold can only grow on organic material, so mold or mildew will never be an issue on our ceiling tiles. They will not sag from moisture in the middle, giving an eternal crisp, clean finish. Our tiles even come with a 30 year warranty against mold and sagging. After the installation of the new drop ceiling, the basement was much brighter and had a clean appearance. The stylish crown molding around the perimeter of the room gives a beautiful transition to where the wall meets the ceiling.
Plumbing - Check locally for required permits and any zoning law regulations about adding in plumbing, or whenever working with septic and sewer lines. Planning your basement bathroom directly below or close to the pipes of an existing bathroom may help reduce the overall labor and costs. Remember that all drainage lines require a downhill slope to sluice away waste water. If this isn't possible, a sewage injection pump must be installed. An approximate cost of these pumps ranges from $150-$3,000.
In most cases, your HVAC system should already extend to the basement. If not, however, plan on running additional ducts or vents to ensure the finished rooms are adequately heated. Running new ductwork through your basement will cost around $2,000. Radiant heat is another option for basements, as it can be controlled separately and used only when the basement is. Radiant heat costs around $6,000 - $14,000 depending on the method used.
After your new bathroom is complete, or you have remodeled an existing space, get it inspected to ensure all plumbing and electrical installation are done correctly. If your bathroom needs to be installed from the ground up, expect to pay somewhere between $6,000 and $15,000 for the entire project. If your basement is already finished but does not yet have the necessary plumbing for a bathroom in the space, you can expect to pay between $200 - $500 to hire a plumber.
Last year I bought a house that had the stainless steel micro model installed. The house was surrounded by 80' tall Maples & Birch. TONS OF LEAVES.Yes, it the micro mesh keeps all leaf and seeds out of the gutter 100%. What the manf and dealers won't tell you is that you must clean the mesh 2x's a year to get spring pollen, mold, & fall leaf dust off. Otherwise it will eventually keep EVERYTHING out, including WATER. Major ice problems flowing over the gutters. No it was not the result of ice damming. I removed it all & just deal with the leaves 3x's each fall.Got ranch home with easy access to the gutters - get the micro mesh. Easier to clean that than clean gunk out of the gutter.hire a young buck to climb a ladder. A whole lot cheaper.
In addition to floors and walls, upgrading your basement ceiling is another option to consider. Finishing your basement creates a new room in your home and a part of any room is the ceiling. While it's cheaper to leave the ceiling the way it is, many basements have exposed wiring and duct work that service the home above. In certain cases, leaving all this exposed may be the better option, but for others, upgrading the ceiling could be the right choice. Understand that any addition to the room will up the overall price, so be sure to make the right choice for the space and your wallet.
The basement depicted here had unused space underneath the stairs. Why not transform this area into a storage or display area instead? These homeowners found some usable square footage in their home by remodeling their basement into a space-conscious hangout, an inventive and creative strategy that shows you don't have to substitute style for function.
Finished basement on high end house. I designed all of it and spent some time managing the process. Already had lots of windows (walk-out). Used high end materials and design features ( plank laminate flooring with some granite/marble, rope lighting, recessed panels,heavy finish trim molding, recessed lighting, rope lighting, central audio/speakers, full kitchen, full bath,fireplace, zoned HVAC, etc). Took almost 9 months to complete fully. Great finished product.
If you choose a basic do-it-yourself makeover, including adding moisture control, framing in walls and adding decor and furnishings, your cost will run between $10,000 and $27,000. Waterproofing sealants and additional insulation are just a few of the considerations that will be factored into the final finished basement cost. The price will, of course, also be affected by how much renovating is being done.
Consider what you can do yourself. Finishing your basement is a full process and is not easy. But if you're looking to save money and are quite handy, consider waterproofing the basement yourself. Basement waterproofing with SANI-TRED® uses a proven application process that is perfect for the do-it-yourself community. You can (and should) hire contractors for specialized tasks like plumbing or electrical, but many can do the waterproofing yourself for less.
Last year I bought a house that had the stainless steel micro model installed. The house was surrounded by 80' tall Maples & Birch. TONS OF LEAVES.Yes, it the micro mesh keeps all leaf and seeds out of the gutter 100%. What the manf and dealers won't tell you is that you must clean the mesh 2x's a year to get spring pollen, mold, & fall leaf dust off. Otherwise it will eventually keep EVERYTHING out, including WATER. Major ice problems flowing over the gutters. No it was not the result of ice damming. I removed it all & just deal with the leaves 3x's each fall.Got ranch home with easy access to the gutters - get the micro mesh. Easier to clean that than clean gunk out of the gutter.hire a young buck to climb a ladder. A whole lot cheaper.
Storage is key in a multipurpose space. There are several storage units throughout this basement. An IKEA cubby bookcase is a perfect fit for the office niche. Orange baskets corral small items and add spots of color to the basement's storage solutions. Stock cabinetry did not fit in the bar or media spaces, so the homeowners opted for costly, custom cabinets. Experiment with different types of storage units in your home to utilize every possible space.
Once you've completely waterproofed and your basement is protected, you can move on to the room's interior. Choosing the right flooring is an important part of making your finished basement truly your own. The type of flooring material you choose will definitely factor into your final price, so choose wisely and pick the floor that's best for your finished basement.
You can fit a full bathroom with tub/shower combination in a room that measures 40-square feet. However, on average, a smaller bath (with just a stand-up shower) or a half-bath usually needs to be about 30-square feet for comfort and functionality. Depending on the basement space and layout, you may be able to go with a larger 60-square feet or more bathroom space. Creating bathroom with a separate water closet may require 100-square feet or more.


text:
Dietary supplements are substances you might use to add nutrients to your diet or to lower your risk of health problems, like osteoporosis or arthritis. Dietary supplements come in the form of pills, capsules, powders, gel tabs, extracts, or liquids. They might contain vitamins, minerals, fiber, amino acids, herbs or other plants, or enzymes. Sometimes, the ingredients in dietary supplements are added to foods, including drinks.
Save 43%
Lypofit Duo Surgery-free Removal of Belly
KES3,420 KES6,000In stock, 687 units
Save 54%
Night Effect Slimming Capsule BUY 5 @KES 9,870
KES9,870 KES21,600In stock, 199 units
Save 21%
KES4,320 KES5,500In stock, 579 units
Save 60%
Night Effect Slimming Capsule BUY 7 @KES 12,100
KES12,100 KES30,240In stock, 200 units
Save 51%
Night Effect Slimming Capsule BUY 3 @KES 6320
KES6,320 KES12,960In stock, 200 units
Save 50%
Mangosteen Weight Loss Powder
KES3,490 KES6,980In stock, 200 units
Save 22%
MABOX 30ML Vitamin C Serum
KES2,500 KES3,200In stock, 90 units


text:
Pe 17 in Cochrane, Ontario
Below this text you can see the position of the Pe 17 on the Cochrane street map (ON, Canada). (Map powered by Google). GPS coordinates for the Pe 17 are: 49.59285,-82.78159. Anything interesing in Pe 17? Add it as comment on bottom of this page.
Pe 17 on map:
Anything interesting in Pe 17 in Cochrane, CA
If you know any interesting object or business in Pe 17 (Cochrane), please share it with others. Place comment using your Facebook, Hotmail, Yahoo or AOL account:
Random streets in Cochrane:
Below is just random list of streets in Cochrane. For full list go to Cochrane street map start page.Kineras Lake Road Clute Leitch Access Road Beadman Road Rapids Avenue Museum Road Malherbe Road 11th Avenue Hurtubise Road Highway 634 Fir Road Road 3 Connaught Evelyn Road Esker Lake Park Road Pike Creek Road Norbord 4 Road Rivard Road


text:
A serial scofflaw who accumulated a perilous number of felony convictions in Ohio is in grave danger of serious federal prison time related to an October 2019 firearm and methamphetamine arrest in Claiborne County, according to court documents.
A federal grand jury in Knoxville on Tuesday indicted Shane Nolan Franks, 47, for being a convicted felon in possession of a firearm, possession of a firearm – a Bryco 9mm handgun – in furtherance of a drug-trafficking offense and possession with intent to distribute more than 5 grams of meth. The grand jury results were posted on Wednesday.
Under normal circumstances, Franks would be facing 10 years in federal prison – five for the crystal meth and a consecutive five for a firearm offense, but his sentence could be much longer. His overriding problem involves prior convictions for violent felonies.
In 1998, he was convicted of felony robbery in Dayton. Six years later, he was convicted of felonious assault with a deadly weapon in Xenia, according to a criminal complaint drafted by Rebecca Bobich, a Bureau of Alcohol, Tobacco, Firearms and Explosives agent.
Defendants who have convictions for violent felonies that are separated in time can be declared armed career criminals and face a mandatory minimum 15 years behind bars if convicted of firearm possession in federal court. In some circumstances, federal prosecutors disregard a violent felony conviction after getting a guilty plea, but the matter seems to be mostly out of Franks' hands.
On Oct. 11, 2019, Claiborne County Detective Eddie Hurley and Lt. Stephen Hurley located Franks, who had outstanding warrants for unspecified offenses, at a mobile home park on Saddle Ridge Lane in Tazewell. Hurley allegedly was holding 4 grams of meth. Another 14 grams of crystal meth, the handgun and $2,685 in suspected drug-sales proceeds allegedly were found in a car.
Kentucky resident Shawn Christopher Wright, who was arrested in Claiborne County in November 2019 while he and an accomplice were burglarizing a Harrogate home, is in a situation similar to Franks.
Assistant U.S. Attorney LaToyia Carpenter on Tuesday filed a factual basis that indicates Wright, 48, will plead guilty to possession of more than 5 grams of crystal meth and possession of firearms, a loaded .38-caliber handgun and a loaded AR-15-style rifle, by a convicted felon.
Wright's starting point will be 10 years. If his prior convictions, which were not detailed in the factual basis, qualify him as an armed career criminal, his presumptive bottom-of-the-range sentence will be 15 years, according to the federal prosecutor.
The defendant and his accomplice, a woman named Toni Andrews, had a clawfoot bathtub loaded in the back of a pickup when Claiborne County Deputy Seth Miracle arrived to investigate. Miracle confiscated about 40 grams of crystal meth, 3.5 grams of heroin and 49 clonazepam pills for which neither Miracle nor Andrews had a prescription, according to Carpenter.