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Planetary ball mills are smaller than common ball mills and mainly used in laboratories for grinding sample material down to very small sizes. A planetary ball mill consists of at least one grinding jar which is arranged eccentrically on a so-called sun wheel.
Summary. The Kurimoto High G consists of a main unit which revolves and mill pots which rotate in the same and opposite directions. You should put grinding medium (usually small-diameter balls) and material in the rotating mill pot to move the balls applying centrifugal force generated during revolution and rotation for processing (i.e., grinding).
The ball mill is a key piece of equipment for grinding crushed materials, and it is widely used in production lines for powders such as cement, silicates, refractory material, fertilizer, glass ceramics, etc. as well as for ore dressing of both ferrous and non-ferrous metals. The ball mill can grind various ores and other materials either wet or dry.
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A mill is a device that breaks solid materials into smaller pieces by grinding, crushing, or cutting. Such comminution is an important unit operation in many processes.There are many different types of mills and many types of materials processed in them. Historically mills were powered by hand (e.g., via a hand crank), working animal (e.g., horse mill), wind or water ().
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The Planetary Mill Pulverisette 5 allows rapid, batch grinding of hard to soft material, dry or in suspension, down to colloidal fineness. Maximum sample quantity: 900 ml. It can also be used for mixing and perfect homogenising of emulsions and pastes.
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There are three grinding roller wheel assemblies in the mill grinding section, which are mounted on a loading frame via pivot point. The fixed-axis roller in each roller wheel assembly rotates on a segmentally-lined grinding table that is supported and driven by a planetary gear reducer direct-coupled to a motor. The grinding force for
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Calgary police have identified the man found dead on a suburban Calgary street Thursday morning following reports of gunfire in the area.
His name is Cuong Hoang — he also goes by Andy Cuong Hoang — and he was found shortly after 9:30 a.m. in the 0 to 100 block of Auburn Sound Circle S.E.
tap here to see other videos from our team.
Police identify victim in Auburn Bay homicide Back to video
Police are not releasing the cause of the man's death until an autopsy is completed.
According to court documents, Hoang has criminal charges dating back to 1992.
In 2000, the 46-year-old was convicted of conspiracy to commit drug trafficking and handed a three-year sentence and 10-year firearms ban. He was at the centre of a cocaine bust dubbed Operation Sockeye in 1998 that saw two other people arrested.
Police do not believe Hoang's death was a random attack, but are still trying to establish a motive. Investigators also recovered a beige minivan in connection to the case from an undisclosed location in the southeast, and continue searching for suspects in the death.

subset: commoncrawl


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Ryan Ober, guitarist for metalcore band Ligeia, is the guest on this episode of the BREWtally Speaking Podcast!! Continue reading
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VIDEO: East Lyme First Selectman Mark Nickerson re-elected by close margin
East Lyme — Republican First Selectman Mark Nickerson was elected to his third full term on Tuesday, winning by a close margin against Democratic challenger Camille Alberti, with an outcome of 2,802 to 2,618 — a difference of 184 votes.
"I'm very excited to be victorious and that this town will still be a Republican-run town, and let's be thankful for that," Nickerson said at an election after-party held at Flanders Fish Market after seeing that many new Democrats were elected onto many boards and commissions. "And we are going to be a Republican-run Board of Selectmen, and that's important, too."
Nickerson ran on his 20 years of experience in town government this election season, as well as his "proven track record" of completing various projects in a timely manner and "on budget." He is the owner of two local GEICO offices and previously has served on the Board of Selectmen and Zoning Commission. He became the town's first selectman in January 2015 — when then First Selectman Paul Formica became a state senator — and was elected to his first full term in November 2015.
Nickerson points to a list of accomplishments over his five-year tenure, noting how he spearheaded establishing an independent police force and helped reel in the recent $37.5 million elementary school renovation project on budget. He also has touted many other projects he helped oversee, including the completion of the Niantic Bay Boardwalk and the recently completed Main Street park, as well as the continued expansion of the Gateway Commons housing development and construction of a Costco, scheduled to open Nov. 14.
Alberti, a member of the Board of Finance since 2013, ran on a platform of responsibility and accountability, as well as calling for more transparency within town government. She took aim at Nickerson throughout this election season, questioning his decision-making as first selectman and alleging mismanaged project planning over his tenure.
Alberti cited the ongoing police building renovation plans at the former Honeywell office building at 277 West Main St. as a primary example of project mismanagement. Initial estimates for the building came in millions higher than voters had budgeted for the project, becoming one of this election season's biggest talking points between candidates.
Nickerson has adamantly maintained that renovations will come in on budget and that the unfolding process is typical for architects trying to plan and budget renovations.
Throughout her campaign, Alberti also questioned some of Nickerson's policy decisions and has called for a less top-down approach to governing, sparking many conversations and questions among residents on social media, while also promising to overhaul many of the town's policies and procedures.
Alberti was not immediately available for comment Tuesday night.
"I never doubted my opponent's willingness to serve and her aggressive approach to getting this done," Nickerson said. "... We still have a lot of work to do and I need your help. ... Have you looked at that list of accomplishments that we've done in the last five years? It's amazing. And we have a lot to accomplish in the next two, and we are going to get that done."
Voter turnout was about 42.2 percent.
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By A.C. Thompson and Patrick G. Lee, Propublica
Last year, lawmakers in South Carolina introduced legislation that would have increased the standard penalties for anyone who assaults, intimidates or threatens another individual if they did so because of the victim's "race, religion, color, sex, age, national origin, or sexual orientation.â€
Drafted by Democratic legislators after white supremacist Dylann Roof murdered nine African-American parishioners at a church in Charleston, the bill never even came up for a vote. It was a familiar fate. In recent years, at least a half-dozen other hate crimes proposals have died in the South Carolina statehouse.
Much the same story played out in Indiana, where Republican state Sen. Susan Glick authored similar legislation in 2016; Glick's bill would have increased time behind bars for those convicted of harming or intimidating someone if the assailant's motivation was driven by the victim's gender identity, disability, sexual orientation, race, religion or immigration status
The legislation passed in the Senate by a vote of 34-16 but died in the House without so much as a hearing.
In the five states without hate-crime laws, there is little question that Christian activists have had an impact.
Since the 1980s, nearly every state in the union has enacted some sort of hate crimes law, as have Washington, D.C., and the federal government. While the laws vary from state to state, they generally bolster penalties for those who commit crimes — assault, vandalism, credible threats of physical violence, among others — because of some sort of bias against the victim.
South Carolina and Indiana are among a small handful of states that have failed to pass such laws. Wyoming, Arkansas and Georgia are the other hold-outs.
Much of the opposition to creating hate-crime legislation in these states has come from well-organized groups of Christian fundamentalists who on religious grounds disapprove of any sort of legal protections for gays, lesbians and transgender people. For these critics, the primary concern is legal language stepping up punishment for crimes motivated by contempt for the LGBT populace, measures they view as a small but dangerous part of a broader "homosexual agenda.â€
One of the Christian groups is the Family Research Council. Contacted by ProPublica, the FRC's national office directed questions about hate crimes to Ryan McCann, an Indiana activist and lobbyist who works with the organization.
McCann views hate crimes laws as a sort of Trojan Horse: If Indiana adopts such a law, McCann said, LGBT advocates will use the precedent to argue for further legal safeguards, including anti-discrimination statutes, which he opposes.
Christian conservatives such as McCann have become potent activists against hate-crime legislation — lobbying, organizing their followers to petition statehouse lawmakers, and providing many of the key arguments against the laws.
"Homophobia and resistance to providing protections for LGBT people obviously play a role in the push back,†said Robin Maril, associate legal director for Human Rights Campaign, a national LGBT advocacy organization.
Statehouse experts are quick to point out that Christian conservatives aren't the only people who can be hostile to hate crimes laws.
Jeannine Bell, a law professor at Indiana University's Maurer School of Law, said some legislators in that state believe the laws will create an inequitable justice system that "serves particular groups and not others.†(Bell, who has studied the laws, disagrees: "That is a misunderstanding. Everyone has a race.â€)
Lynne Bowman of Human Rights Campaign noted that, in general, Republican-controlled legislatures have not been supportive of hate crimes bills regardless of the language.
The range of concerns can include worries about limiting free speech or doubts that police and prosecutors can truly know a perpetrator's state of mind or motivations at any given moment. There have even been some expressions of misgiving among civil rights advocates that the legal hurdles created by hate-crime laws — establishing with certainty, for instance, someone's specific motivations — can be counter-productive.
Decades ago, in a landmark 1993 ruling, the U.S. Supreme Court examined the fundamental fairness of hate-crime legislation. The court held that carefully crafted hate crimes laws do not infringe on the free exercise of speech, a finding that resolved the major constitutional questions on the matter. The case centered on a racially motivated incident in Wisconsin in which an African-American man assaulted a white teen, leaving the victim in a coma.
In the five states without hate-crime laws, however, there is little question that Christian activists have had an impact.
Bowman, a senior field director with Human Rights Campaign, said "homophobia†gives lawmakers "an easy excuse to stand up against these bills.â€
For the past two decades, much of the resistance to hate crimes legislation has been orchestrated by a trio of intertwined conservative Christian groups.
The oldest and most prominent is Focus on the Family, the Colorado-based ministry founded by James Dobson. The sprawling organization, which produces a vast array of media on biblical topics and funds anti-abortion counseling centers for pregnant women, operated on a budget of nearly $90 million in 2013, the last year for which full tax records are available.
Focus on the Family portrays hate crimes laws as part of a plot to marginalize Christians and ban them "from the public arena.â€
Dobson's ministry helped to spawn the Alliance Defending Freedom, a network of fundamentalist Christian lawyers who have argued that the laws infringe on religion while "creating additional legal protections for those engaged in homosexual behavior that are not available to everyone else.â€
But it is the FRC, a third offshoot based in Washington, D.C., that has emerged as perhaps the most effective foe of hate crimes legislation.
When Congress took up the issue in 1999, an FRC leader told the Senate Judiciary Committee that revising the federal code to cover hate crimes could lead to the prosecution of "people who merely oppose homosexual activism.†Ten years later, as Congress debated the Matthew Shepard and James Byrd, Jr. Hate Crimes Prevention Act, the FRC decried the act as a "thought crimes†bill.
Since then, the "thought crime†claim has become a common talking point in conservative Christian circles and the FRC's regional chapters have sought to halt hate crimes legislation at the state level.
It's absolutely not true. But it sounds scary and it plays into people's fears.
In 2007, the FRC chapter in Arkansas urged lawmakers there to vote against hate crimes legislation authored by a veteran Democratic legislator. The bill failed. In a blog post, chapter leader Jerry Cox proudly touted the group's accomplishments, saying it had spent years fighting "to make sure Arkansas' civil rights and hate-crimes laws are not used to promote a homosexual agenda.â€
McCann of the FRC is straightforwardly explicit about the group's thinking.
"The gay-rights groups and the folks on the left only want to get the terms 'sexual orientation' and 'gender identity' into the law,†said McCann. "Unfortunately, that's all they care about — their agenda.â€
In Indiana, groups affiliated with the FRC have enjoyed great success in killing hate crimes bills over the past decade. The Republican Party currently enjoys a super-majority in the state, controlling both legislative chambers and the governor's office. But "even under Democrat rule these hate crimes bills didn't get a hearing,†said McCann, who helps to lead the Indiana Family Institute, a group associated with the FRC and Focus on the Family.
Currently McCann is pushing legislators to stop five different hate crimes bills pending in the statehouse.
Though the FRC describes its mission as the advancement of "faith, family and freedom in public policy,†critics take a very different view: The Southern Poverty Law Center has dubbed it an anti-gay "hate group.â€
The FRC has vigorously denied the characterization. The allegations are "an attempt to discredit FRC's work and cut us out of public policy debates and media coverage over homosexuality and same-sex 'marriage,'†the organization said in a 2010 statement.
The FRC has cultivated powerful allies, some of them in the White House. As Wired recently reported, both President Donald Trump and Vice President Mike Pence appeared at the organization's "Values Voter Summit,†while a range of current or pending administration officials — Reince Priebus, Mike Pompeo, Tom Price, Jeff Sessions — have all spoken at FRC events. Ed Prince, the father of Betsy DeVos, provided millions of dollars in funding to the FRC in the group's early days. DeVos, a Michigan billionaire, has been tapped by the Trump administration to serve as U.S. secretary of education.
While 45 states have enacted hate crimes laws, the statutes vary dramatically around the country. In 15 of those states, the laws do not cover gays and lesbians; in 28 they don't cover gender identity or transgender individuals.
In Georgia, state Sen. Vincent Fort, a Democrat, said he has sponsored at least five bills that have been defeated largely because they covered sexual orientation. "Some people have said, 'If you don't include gay people, it might pass,'†he recalled. Still, he insists he'll never support "any bill that excludes gay people. I'm not going to have anything to do with a hate crimes law that, in effect, is discriminatory. Wouldn't that be ironic?â€
Wendell Gilliard of South Carolina tells a similar tale. A Democrat from Charleston, Gilliard has introduced "four or five hate crimes bills†in the state House of Representatives — and all of them have come to nothing. The lawmaker, who is African-American, said he's been barraged with angry emails and phone calls about his bills — not about race but from people "quoting biblical verses about homosexuality.â€
Opponents of the bills under consideration in Indiana claim the legislation, if passed, could be used to prosecute preachers who portray homosexuality as a sin. "Let's pray that silencing speech is not the next step in the 'gay' agenda that the media embraces and pushes in the statehouse,†wrote Micah Clarke, an Indiana lobbyist and leader of an FRC chapter, in a newsletter sent to his group's members.
Clarke declined to be interviewed.
"There are gay-rights activists all over the country who are trying to silence those who don't agree with them,†said McCann, the Indiana lobbyist. As far as he's concerned, the bills provide special treatment to members of "favored political classes†and are likely to muzzle fundamentalist Christians.
"Those are 'alternative facts,'†said one clearly frustrated lawmaker, Greg Taylor, a Democrat from Indianapolis who has authored two hate crimes bills currently pending in the state Senate. "It's mind-boggling.â€
Robin Maril of Human Rights Campaign describes the rhetoric coming from her political foes in Indiana as "irresponsible†fear-mongering.
"It's absolutely not true. But it sounds scary and it plays into people's fears,†Maril told us. "None of this legislation would ever impede an individual's ability to speak out. ... We are not policing ministers' ability to give sermons.â€
A.C. Thompson covers criminal justice issues for ProPublica. He has been a reporter for 12 years, mostly in the San Francisco Bay area.
Patrick Lee is a reporting fellow at ProPublica.
Originally published by Propublica, republished from New America Media.
Photo Credit: Chicago Man via photopin (license)


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The FCA's temporary suspension of payments processed through Wirecard has now been lifted. But it seems that some customers of UK payment services providers continue to have issues access their accounts. Given that a quarter of UK families have less than £100 in savings, and many more are living one paycheque to the next, any disruption, particularly one occurring around payday, is a significant issue, and one that will cause real customer detriment to consumers.
These are the kind of stories that appear in MPs' inboxes, find their way to the ears of Treasury Select Committee members, and end up in the "something must be done" pile at the FCA – as the Wirecard failure impacts two of the three pillars of the FCA's conduct risk objectives: good customer outcomes, and market confidence.
To be fair to the regulator, the FCA have been increasingly vocal about the PSP sector. And perhaps they are taking the view that the balance between opening up markets to innovative competitors, and conduct risk requirements, may need adjusting. There are echoes here to the experience with peer-to-peer lending – where the initial positive and supportive approach from the FCA soon changed when the regulator took the view that the sector had not heeded warnings to put its house in order.
FCA focus on PSPs
In late 2019, the FCA highlighted that payment service providers – or PSPs – would be in scope in their work on building operational resilience. In early 2020, it was announced that PSPs would be a priority area of focus in the FCA 20/21 Business Plan. And this was followed in May by proposals for additional temporary guidance. This paper focused on the prudential risks of PSPs, the need to have effective safeguarding in place for customers' funds, requirements for robust risk management controls and realistic wind-down plans. So the Wirecard situation will only serve to concentrate the regulator's mind further.
Payment service providers – meeting the FCA's expectations
PSP firms should therefore look to put their own houses in order, before the FCA comes knocking:
Prudential stability
The prudential requirements highlighted in the FCA's paper are important. However, prevention is better than cure, so ensuring the soundness of the underlying framework of the firm is key.
Operational resilience
The formal consultation on operational resilience has been put back by the regulator, but the underlying principles remain the same. Issues like Wirecard are Op Risk concerns. Firms should ensure they fully understand their business processes, and are able to identify potential failures, before they happen. Both within their own processes, and with outsourced providers.
This is another hot topic for regulators (with the PRA, FCA, EBA and IOSCO all weighing in, in recent months), and clearly core to the Wirecard issue. PSPs – and to be fair, all firms – should ensure initial and ongoing due diligence is done effectively. In this, the fact that the outsourced provider is regulated in an established jurisdiction (or even regulated by the FCA), is not, in itself, an adequate check. And neither is an audit report from a Big 4 accountancy firm. Firms need to conduct thorough checks prior to signing the contract, and undertake ongoing monitoring that covers both commercial and conduct risks metrics.
All the above points mean nothing if an effective governance and control framework is not in place. Good management and good risk identification and control remain key. And this is a point the regulator is well aware of. PSP firms should anticipate that as part of their review of the sector, the FCA may well propose the introduction of more formalised governance structures.
PSP firms must show they are controlling risks
PSP and the wider fintech sector have helped to democratise and liberalise the financial services marketplace. And this is a positive movement, that should continue. However, that is dependent on firms being able to demonstrate that they have identified and controlled the risks within their operations.


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@MISC{Wai_multisitephosphorylation, author = {Stephanie C. Wai and Scott A. Gerber and Rong Li}, title = {Multisite Phosphorylation of the Guanine Nucleotide Exchange Factor Cdc24 during Yeast Cell Polarization}, year = {}}
Background: Cell polarization is essential for processes such as cell migration and asymmetric cell division. A common regulator of cell polarization in most eukaryotic cells is the conserved Rho GTPase, Cdc42. In budding yeast, Cdc42 is activated by a single guanine nucleotide exchange factor, Cdc24. The mechanistic details of Cdc24 activation at the onset of yeast cell polarization are unclear. Previous studies have suggested an important role for phosphorylation of Cdc24, which may regulate activity or function of the protein, representing a key step in the symmetry breaking process. Methodology/Principal Findings: Here, we directly ask whether multisite phosphorylation of Cdc24 plays a role in its regulation. We identify through mass spectrometry analysis over thirty putative in vivo phosphorylation sites. We first focus on sites matching consensus sequences for cyclin-dependent and p21-activated kinases, two kinase families that have been previously shown to phosphorylate Cdc24. Through site-directed mutagenesis, yeast genetics, and light and fluorescence microscopy, we show that nonphosphorylatable mutations of these consensus sites do not lead to any detectable consequences on growth rate, morphology, kinetics of polarization, or localization of the mutant protein. We do, however, observe a change in the mobility shift of mutant Cdc24 proteins on SDS-PAGE, suggesting that we have indeed perturbed its phosphorylation. Finally, we show that mutation of all identified phosphorylation sites does not cause observable defects in growth rate or morphology.
Developed at and hosted by The College of Information Sciences and Technology
© 2007-2019 The Pennsylvania State University


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Amari Butler
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She launched her TikTok account in July 2016.
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Discover Everything About Live Theater and Theater Programs in Redlands, Highland, Mentone, Yucaipa, and Loma Linda
Over 120 artists from the Western U.S. will exhibit at the sixth Redlands Festival of the Arts, Memorial Day Weekend, May 26-27, 10 am to 5 pm, in Smiley Park. The festival includes a juried art show with artists competing for awards and cash prizes, as well as Art in the Park sponsored by the Redlands Art Association. Bring the whole family to the Kids Zone where children will enjoy our hands-on art activities, free books from Sunrise Rotary and an instrument petting zoo provided by the Redlands Symphony. Enjoy live music, barbecue, lobster, beer and wine. The Smiley Library and the Lincoln Shrine are open as well. Festival admission is free.
LifeHouse Productions is a family of creative artists from the Inland Empire. We are committed to producing dynamic, dramatic experiences championing the moral imagination as informed by Judeo-Christian traditions. LifeHouse is an independent, non-profit corporation funded by ticket sales and the support of volunteers and community contributors.
Established in 1945, Redlands Footlighters Theatre is a volunteer-run arts organization that produces high-quality live theater for the Inland Empire community.
Annual seasons include shows from October - June. Individual tickets $18 / Students (with ID) $12. Season ticket and group rates available.
Join the fun! Help support a 75-year long tradition of quality theatre by joining as a Sustaining Member. Contact us for more information.
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voir la définition de Wikipedia
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Fort Sam Houston
Clock tower built in 1870 inside the Quadrangle on Fort Sam Houston, Texas.
|San Antonio, Texas
|Governing body:
|United States Army
|NRHP Reference#:
|Significant dates
|Added to NRHP:
|May 15, 1975[1]
|Designated NHLD:
|May 15, 1975[2]
Fort Sam Houston is a U.S. Army post in San Antonio, Texas.[3] Known colloquially as "Fort Sam," it is named for the first President of the Republic of Texas, Sam Houston.
The installation's missions include serving as the command headquarters for the United States Army North (formerly the Fifth United States Army), United States Army South, the Army Medical Command (MEDCOM) headquarters, the Army Medical Department (AMEDD) Center and School, the Fifth Recruiting Brigade, Navy Regional Recruiting, the San Antonio Military Entrance and Processing Station, and the Medical Education and Training Campus (METC). On October 1, 2010, Fort Sam Houston joined Lackland and Randolph Air Force Bases to create Joint Base San Antonio, under Air Force administration.
U. S. Department of Defense (DoD) Elements
United States Army North is the senior command and responsible for all Army activities on Fort Sam Houston. Commanded by Lt. Gen. William B. Caldwell IV, Army North's primary missions are land-based Homeland Defense, Defense Support of Civil Authorities and Theater Security Cooperation with the Bahamas, Canada and Mexico. Because Fort Sam Houston is part of Joint Base San Antonio, the installation commander is Brig. Gen. Theresa C. Carter, commander of the 502d Air Base Wing.
Fort Sam Houston is known as the "Home of Army Medicine" and "Home of the Combat Medic." At the end of World War II, the Army decided to make Fort Sam Houston the principal medical training facility.[4] In conjunction with this decision came the determination to develop Brooke General Hospital into one of the Army's premier medical centers.[4] This combined the capabilities of Wilford Hall Medical Center located at nearby Lackland Air Force Base to create the largest medical treatment facility and teaching hospital in the Department of Defense. Construction associated with this transition increased the square footage of the hospital by 50%, including a much larger, variable capacity emergency department, additional surgical suites and recovery facilities, as well as teaching facilities and bed space. Despite the installation transitioning to Air Force control, the command and control of the facilty will remain with the Army. The command and other key positions will rotate between the Army and Air Force. Staffing consist of members of both services, as well as a large number of civilians.[5]
As of 2011, Fort Sam Houston is the largest and most important military medical training facility in the world.[3][4][6] Military Medical Training is provided by numerous elements, including METC, AMEDD Center and School, Brooke Army Medical Center, US Army Institute of Surgical Research, The Center for Battlefield Health and Trauma, Defense Medical Readiness Training Institute, as well as many smaller organizations.
Known as the brain trust for the Army Medical Department, the Army Medical Department Center and School annually trains more than 25,000 students attending 170 officer, NCO and enlisted courses in 14 medical specialties. The command maintains several academic affiliations for bachelor and masters degree programs with major universities such as Baylor University, University of Texas Health Science Centers at Houston and San Antonio, and University of Nebraska.
As a result of the Base Realignment and Closure Commission (BRAC) 2005 recommendations, all military medical training has been consolidated at Fort Sam Houston. This consolidation concluded with the opening of the Military Education and Training Campus (METC) in 2011. The Navy moved its medical training from San Diego, CA, Great Lakes, IL, and Portsmouth, VA. The Air Force moved its medical training from Sheppard Air Force Base, in Wichita Falls, TX. This increased the average student load to more than 9,000 and required additional support staff. This resulted in significant changes in the training footprint on post, requiring construction approaching one billion dollars.[7]
Construction at Fort Sam Houston began in the middle 1870s under the supervision of the military commander of the Department of Texas, Major General Edward Ord, a West Point-trained army engineer. Today, as one of the Army's oldest installations, and with more than 900 buildings in its historic districts, Fort Sam Houston boasts one of the largest collection of historic military post structures. The significant contributions of Fort Sam Houston to the United States were recognized in 1975 when the post was designated as a National Historic Landmark.
The Fort Sam Houston Quadrangle, built by George Henry Griebel, is the oldest structure at Fort Sam Houston. It was originally a supply depot, and during that time, it also housed Geronimo and those Apaches captured with him while the Federal government decided whether they were prisoners of war or common criminals. Legend has it that the deer in the Quadrangle were there because Geronimo refused to eat food he did not hunt.[8] In truth, the deer pre-date Geronimo in the Quadrangle and it is unlikely that the army was concerned with his comfort.[9] It is unknown why the deer were introduced within the confined courtyard of the Quadrangle.[8]
The Quadrangle is now an office complex housing the commanding general and staff of U.S. Army North. Even more consequential than the number of buildings is the historical integrity of the post's different sections, which represent different eras of construction, and reflect Army concepts in planning and design. Careful preservation of these areas allows the post to live with its history, surrounded by the traditions established when the first soldier arrived here in 1845.
Several famous figures have served at the fort. Maj. Gen. John Wilson Ruckman, Commander of the Southern Department, was based at Fort Sam just after the infamous Houston Riot of 1917. Brig. Gen. Billy Mitchell was posted there after being demoted to Colonel for disobeying orders. Dwight D. Eisenhower was posted to Fort Sam Houston twice during his career. During Eisenhower's first post, from 1915 to 1917, he met and married Mamie Dowd, and was again posted at the fort when the attack on Pearl Harbor occurred in 1941. Their first home is one of the buildings preserved as historic monuments.
|This section needs additional citations for verification. (April 2009)
Throughout its existence, a close and harmonious relationship has prevailed between Fort Sam Houston and the City of San Antonio. The two have grown and matured together. The city often has been called the "mother-in-law of the Army" because so many soldiers including Dwight D. Eisenhower, met their future spouses there.
More than 27,000 military and civilian personnel work at the post, with an annual payroll and operating budget of $1.9 billion. Local purchases made by installation activities total almost $105 million annually. Funding for construction projects on post average $30 million annually. Fort Sam Houston has also initiated public–private partnerships to renovate and adaptively reuse significant historic buildings.
In June 2006, the San Antonio Express-News reported that Fort Sam Houston received utility disconnection notices due to budget constraints.[10]
Fort Sam Houston is one of three military facilities in Texas (all in the San Antonio area) to have its own school district, the Fort Sam Houston Independent School District.
The United States Postal Service operates the Fort Sam Houston Post Office at 1804 Stanley Road.[11]
|Wikimedia Commons has media related to: Fort Sam Houston
Coordinates: 29°26′56.69″N 98°26′56.04″W / 29.4490806°N 98.4489°W
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Allocations / Scheduling Coordinator-newpeople2peopleMeadowbrook QLDThis Australian owned and operated engineering company have a longstanding history in the Queensland market and pride themselves on their strong safety...Missing:
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VR / Non-VR GP | General Practitioner | Private billing | Gold Coast New-newCassia Wellness ClinicBurleigh Heads QLD$199,000 - $199,000 a yearA rare opportunity for an experienced General Practitioner to join a well-established integrative clinic on the Gold Coast. You will be working with a team...Missing:
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Caution: This page may be updated without notice...
> Last update: 17/07/20 @ 16:12
We are fully operational.
But to keep our clients and engineers safe, we are doing things very differently.
We are following government guidance and keeping a close eye on the situation as it changes.
Working from home
We are keeping our admin team at home which means they do not have access to all the resources that they used to and it may take us a bit longer to process your paperwork and get things organised.
On the road
Our engineers are operating under government guidelines. They all carry PPE and are following additional hygiene routines. We are actively monitoring sickness and engineers are being paid to stay at home if they may be ill or have been told to self-isolate themselves.
Please observe social distancing, we'll try and keep a 2m gap between us and you... This is hard in some homes and impossible in others, but where possible, keep the gap, show the engineer where to go and retreat into another room.
All engineers carry hand sanitiser and are routinely dry washing hands and skin as well as applying sanitiser between jobs. Some may be wearing gloves (Especially if they have cuts and grazes on their hands). If an engineer requests to wash their hands in your sink, we ask clients to allow this, for everyones benefit.
Face coverings
We are not enforcing face coverings for engineers at the moment - Engineers cannot communicate properly with them on and there are issues with reduced smell (When you work with gas, this can be a problem)... If you would prefer the engineer to wear one, let us know - We will not be offended and will be happy to oblidge. More info on this policy
Wiping down
Where we can, we will wipe down surfaces on completion with anti-bacterial spray... However it's not possible on all surfaces as we do not want to risk damaging any surfaces.
Clear the area
To reduce the risks of surface contamination, clear the area that the engineer needs to work in - We are sorry, but if we move items to get to something, we will not put it back at the moment to help reduce contact time.
Sick/Self isolating or shielding
You must tell us before we attend. We need to manage exposure and if you are sick or shielding we can take steps to lower the risk of you transferring the virus to us or vice versa. We may refuse entry (and charge you for our time) if you are sick or self isolating and we were not told beforehand.
Track & trace
If you get ill or test positive for COVID19 within 7 days of an engineer visit, please let us know so we can take the engineer out of circulation if needed and get them tested. If we become aware of a potentially infected engineer we may pass your contact details to NHS Track & Trace.
Paired teams
When you require more than one person, we have "paired" teams, before engineers would work with anyone, we are no longer able to offer this which means there may be an additional wait for booking in double handed work. Likewise for installs, we used to put 3/4/5 engineers on site, this is no longer possible.
Material deliveries
Most of our suppliers are now back to offering a semi-normal service, however we are still experiencing delays with some items, especially made to order product (Some cylinders and fire beds, etc), we will let you know as soon as we become aware of a delay in the supply chain.
Charges & fees
We may request deposits for more types of work than we usually do. We are charging a failed access fee of £40 for any site that we attend and are subsequently unable to access (This includes key collections where keys are unavailable). If you are made un-employed through covid and are struggling to settle your bills, please phone us and let us know at the earliest opportunity.
Thank You.
These have been challenging times for everyone and from all of us, thank you for your help and understanding.
We wish you all well and if there are any comments you would like to make or if you have any questions, then please do not hesitate to contact us. These are truly challenging times, but we will get through this. As a company we will continue to provide our service to the best of our ability and we will adapt as the situation changes. Once the virus is controlled we will have the financial rebuild of the country to deal with, this will be a long road and we will be here, keeping homes warm, showers hot and people safe from the effects of Carbon Monoxide. Whether a landlord, tenant or business owner, N4 Gas is here to support you.
The dedication shown by some of our engineers since March has been humbling and our clients have been so supportive as we have changed through this period, we cannot thank you enough and look forward to continuing our client relationships and starting new ones as we go forward.
From all of us here - Thank you.


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10 Apr 2020 04:05
I have a great motivation to succeed right here. Skillfully it is a fantastic problem to deal with Americans and other people from so numerous countries. Added to it is that because nine Eleven I wanted to apply in the US once more as a token of empathy to all Americans. I wanted to share my accumulated knowledge and encounter outdoors of Israel to see how I fare outside of my acquainted turf. Monetarily I have to include the flight costs and compensate for my absence to my instant family still left behind. For all these reasons and more I require to skillfully treat as many people as I may recruit, as we are accountable for our marketing too.If you are a new mom, you ought to treat yourself to a working day at your local med spa. You can typically benefit from a variety of treatments, depending on what the place closest you offers. 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Use this tip one-2 times a week and you'll see a difference in pore Botox Naperville size and excess oil.Look on the internet. That's where I found the goods I am utilizing now. Study about the business. We are all in the same boat, searching for the very best body moisturizing product, that is wholesome and does what it's supposed to do. If they offer you a money back again assure and if you like what you study, it will be really worth giving it a attempt.Later in a meeting with all associates of the spa it was apparent that it was the weakest spa income aboard the Solstice at any time. I was talked about as the 2nd very best income maker after Tyson from the Gym, who was the initial. Now I experienced to offer with jealousy and other "evil eye" influences. So when I had the opportunity to communicate at the spa meeting, I praised Dr Botox who had launched me to James the Marlboro Guy.For starters, the Diamond Radiance Glow is so much much more than a facial, Ok? 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Having Islamic tendency, National and Islamic Welfare Party of Afghanistan was announced its existence on 27/12/1383, being founded and registered in Justice Ministry by Mulavi Mohammad Osman Salak Zadeh.
People's Islamic Party of Afghanistan came into being in Kabul on 4/9/1366, which was one of the parties under the protection and support of Communist Regime of Dr, Najib.
Islamic Unity Party of Afghanistan is one of parties came into being near the end of Jehad periods, under special domestic and international circumstances, practically in the form of a coalition of nine Shiites, Jehadi groups of Afghanistan.
An anonymous armed group attacked to a border region "Spinboldak" in Kandahar province on 22/7/1373, while Afghanistan people were put out of patience by harassment of wars among so-called Jehadi parties and bloody, destructive ethnical and partial clashes.
Maoism followers were active in political, military, and particularly cultural areas under different titles independently or supported by groups called Islamic institutions, after Communist coup on 27th April, 1478(seventh of Saor, 1357LHY).
Nationalism is a slump in human beings society which has imposed countless pains and oppressions upon them.
Former deputy National Security Adviser Satish Chandra among other experts have the government to engage with Taliban as their return is an 'inevitability.' The recent commitment for development in Afghanistan by external affairs minister Sushma Swaraj has brought the spotlight back to ...
Pakistan fully supports a political settlement in Afghanistan as the only viable option to end the conflict in that country, says Pakistan Prime Minister Imran Khan. "A Solution to the Afghan imbroglio can be found only through political initiatives," the prime minister said at a meeting ...
The U.S. Special Representative for Afghanistan Reconciliation Ambassador Zalmay Khalilzad briefed president Mohammad Ashraf Ghani regarding his recent trips aimed at the revival peace talks with the Taliban.
Ex-president Hamid Karzai has warned the United States and Pakistan against cutting a deal on Afghanistan's future.
India has signed 11 memorandum of understandingS (MoUs) with Afghanistan for 26 projects worth 9.5 million dollars.
Afghanistan's new ambassador to the United States has presented her credentials to President Donald Trump.
At least four people, including three security force members and a civilian, were killed when a truck bomb detonated near a compound that houses foreign workers in Kabul, an official said Tuesday.
India on Sunday said it was committed to the economic reconstruction of Afghanistan and to promote an inclusive "Afghan-led, Afghan-owned and Afghan-controlled" peace and reconciliation process in the war-torn country.
The US special representative for Afghanistan reconciliation has arrived in China in an effort to facilitate an intra-Afghan political settlement.
Mullah Mirwais, a key member of Taliban, was killed in a night raid conducted by Afghan forces in Qarabah district in Kabul on Sunday night, Qarabagh District Governor Mohammad Zarif Rashid said on Monday.
An Afghan official says at least nine people were killed when a gas cylinder exploded in Kabul.
Afghan forces have killed 21 Taliban and 10 Daesh militants in operations in two provinces of the country, defense ministry said Sunday.
US Secretary of State Mike Pompeo has talked with Commander of Resolute Support Mission about Afghan peace process.
Salang pass which connects northern parts of Afghanistan to the capital Kabul has been blocked due to heavy snowfalls, an official said on Saturday.


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100% Syrah (mid-1980s) from loose red gravel soils (grès), a little clay on Cabrières Nord (N-W), 80% destemmed, 25 day steel vat vinification at 25°-28°C, pumping overs, cap punching, aged 2-year ex-white wine 228-litre oak casks 20-22 months, first wine 2015, 600-1,000 b
2019 ()
(cask, sugars finished, malo not) dark colour; there's depth of fruit on the nose, black fruits, mulled blackberries, prune fruit, the sun in them. The palate holds comfy gras, layered fruits, ripe tannins, fair control on the finish. It gives a lot of nourishment, is knife and fork wine, not heady, just very rich. Sip this. It's 16.5° to 17°. 20-22 years Oct 2019
2018 ()
(cask) dark red; there are trails of blackberry lozenges on the bouquet's fruit, cassis leaf. The palate has a flavour of prune fruit, a gourmand style, almost plush, gummy max tannins. There is tar, licorice on the close. I would prefer more definition. I'm not sure about the ID of its place showing. Oak shows towards the rather dry for now finish. From 2023. 2038-40 Oct 2019
2016 ()
medium red robe. The nose shows strong oak, charcoal, which masks some actually quite bright cassis-blackberry fruit within. The palate is a little grilled, has a trim ball of richness, the oak right around it, though, a distraction, on the outside. I find the sweet oak drying overall, so it has to soften over considerable time, while the wine's gras starts to amplify, then diminish. The parts are not in balance here, and it's atypical. 14.5°. 2029-30 Mar 2018
2015 ()
(casks, bottling Oct 2017) inky, dark robe, plenty of legs. The nose is a big bundle of black fruit with overtly smoked oak, cassis and black coffee, black olives. This isn't like a Grenache-founded wine. The palate is broad, definitely muscular, a Large Scale Production, nowhere to hide from it. There is swish-swash of black cherry fruit along the way, a note of violets, perhaps from Syrah (tasted blind). Its cellar exertions remain with it firmly for now, so it needs leaving until even 2021. Is it really Châteauneuf like this? Hmm, not sure. 14.8°. 100% Syrah. 900 b. 2031-33 Sept 2016


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In a open pit coal mine, the pit bottom would be the bottom mined coal seam elevation, since it is usually feasible to extract multiple seams when surface mining coal. In a hard rock mine, the bottom of the pit would be the lowest level (elevation) that mining would be conducted on the ore being mined.
Coal Standard Operating Procedure (SOP) No. 3.9 Land Quality Division SUBJECT: Consultation with the Wyoming Game and Fish Department Concerning Sage Grouse in LQD Permitting Actions. Forward The attached Standard Operating Procedure is the policy of the Land Quality
MSHA HANDBOOK SERIES U. S. Department of Labor Coal Mine Safety and Health June 2016 Handbook Number: PH89-V-1 (27) Coal Mine Health Inspection Procedures . CHAPTER 1 - RESPIRABLE DUST . COAL MINE HEALTH INSPECTION PROCEDURES HANDBOOK such as shaft sinking or contract mine maintenance. These activities shall be sampled by MSHA personnel
Division of Coal Mine Workers' Compensation (DCMWC) and as they are screened, developed, evaluated for evidentiary sufficiency, adjudicated, tracked, reconsidered (if applicable), referred for litigation (if applicable), and administered. In addition, Part 2 includes procedures for handling post-entitlement and claims maintenance actions on claims
Coal mining - Coal mining - Underground mining: In underground coal mining, the working environment is completely enclosed by the geologic medium, which consists of the coal seam and the overlying and underlying strata. Access to the coal seam is gained by suitable openings from the surface, and a network of roadways driven in the seam then facilitates the installation of service facilities
Coal mining, extraction of coal deposits from the surface of Earth and from underground. Coal is the most abundant fossil fuel on Earth. Its predominant use has always been for producing heat energy. It was the basic energy source that fueled the Industrial Revolution of the 18th and 19th
Coal Operators' Conference Faculty of Engineering and Information Sciences 1998 Mine maintenance - the cost of operation O. Krellis T. Singleton Research Online is the open access institutional repository for the University of Wollongong. For further information contact the UOW Library: research-pubsuow.edu.au Publication Details
Before commencement of coal mining operations, a mining and reclamation permit must be obtained from the Oklahoma Department of Mines Coal Division. A coal permit is issued when the mine operator submits and acceptable application and posts adequate bond to cover reclamation costs, should it be necessary for a third party to complete the
Principal Mining Hazard Management Plans for principal mining hazards identified at the workplace. For any further information about this Guidance Material or Principal Mining Hazard Management Plans please contact the Helpline on. 1300 366 322 . or if outside Tasmania (03) 6233 7657
the coal seams determine the mode of extraction. Shallow, flat coal deposits are mined by surface processes, which are generally less costly (per ton of coal) than underground mines of similar capacity. Strip mining is one of the most economical surface processes. Here removal of overburden and coal
approach for identifying potential production or maintenance operational losses (MDG1010 . Risk Management Handbook for the Mining Industry).' WRAC is a specific qualitative risk assessment method designed to be applied when an organisation wants to understand its risks and clearly identify the priority or highest risks in its operation. 5.
(a) has at least one year's experience in a coal mine of which at least 90 days have been spent in work associated with the undergound operation of a diesel locomotive; and (b) is trained and authorized to operate the diesel locomotive in that portion of the coal mine. Maintenance, Inspection and Tests
Duralie Coal Mine – Topsoil Stripping Management Pl an CIM-09TOPSOIL STRIPPING MANAGEMENT PLAN.DOC27 NOV 2007JT:j 1 INTRODUCTION The Duralie Project Open Cut is being developed by Duralie Coal Pty Ltd (DCPL). The Duralie Coal Mine (DCM) is located in a secluded area of cleared grazing land east of the Bucketts Way,
Underground mines are inherently dangerous environments considering both illness and accidents there are around one million work related deaths around the world every year. The mining industry takes safety very seriously with an aspiration goal of zero fatalities. The safety of workers must always be of primary importance in any mining activity.
Improving fundamental stockpile management procedures P. Keleher D. Cameron Coal Quality management and the control of the flow of coal through complex mining preparation and transport phases 2. at the washplant -where clean coal stocks require careful maintenance to
Rail track and associated equipment for use underground in mines Guidance on selection, installation and maintenance Contents Status of document 3 Introduction 4 Some basic principles 4 What the guidance covers 4 Who the guidance is for 4 The legal framework 4
Environmental procedures have been established, documented and maintained for all mining related activities that have a potentially significant impact on the environment. Procedures provide details of operation and maintenance of facilities, equipment and machinery where required.
Coal mining is only a temporary use of land, so it is vital that rehabilitation of land takes place once mining operations have stopped. In best practice a detailed rehabilitation or reclamation plan is designed and approved for each coal mine, covering the period from the start of operations until well after mining
Emergency Medical Procedures; Experience coal mining in a simulated mine; Job opportunities for graduates include maintenance foreman, repairman, miner, and various mine technician positions. In addition, skills acquired in this program - such as machine repair, welding, hydraulics and electrical skills - are applicable to occupations outside
----- INDUSTRIAL STORMWATER FACT SHEET SERIES Sector H: Coal Mines and Coal Mining-Related Facilities A stormwater permit generally is not appropriate for the following types of coal mines: 4 Sites or parts of sites which are determined to cause or contribute to water quality standards violations 4 Active facilities and those under reclamation, which have discharges subject to effluent
Standard Laboratories, Inc. has the facilities to provide a wide variety of coal sampling and testing, as well as other support services for the coal mining and processing industries. We have facilities and partner companies throughout the United States to assist projects in any region of the country.
India has emerged as the third largest coal producer in the world after China and USA with a 9% share of the total global coal production. While the coal production from underground mining in countries like China, USA and Australia are about 95, 33 and 20% respectively, India produces only about 15% of coal from underground mines (Prasad 2009).
Reporting to the Dragline Maintenance Supervisor, the Mine Electrician's duties include safely and efficiently performing electrical repairs and maintenance on all types of surface coal mining equipment and mine electrical infrastructure. as well as with the policies and procedures of individual business units and the laws and regulations
Maintenance management of equipment in coal mines - Download as Powerpoint Presentation (.ppt / .pptx), PDF File (.pdf), Text File (.txt) or view presentation slides online. This is related to maintenance strategy of equipment in coal mines
maintenance and non-maintenance related downtime. Non-maintenance related downtime may be attributed to lack of demand, an interruption in raw material supply or production scheduling delays beyond the control of the maintenance function. Asset utilization is also a function of operating rate, quality and yield losses, etc.
Aug 02, 2019Job Description. Under the general direction of the Plant Manager supervise union personnel on rotating shifts while ensuring that the operation and maintenance of the Coal Valley Mine coal wash plant complies with authorized practices and procedures, and operational requirements are accomplished in a safe and efficient manner.
Use safe work procedure, regardless of low risk or repetitive maintenance, when working on large energy plant. Integra Shearer Shear Shaft Maintenance. 04/04/2009 - Integra Underground Coal Mine. A longwall crew was replacing a broken drive shaft on the ranging arm of a longwall shearer. The drive shaft had a spline on each end and required
REFUGE STATIONS/BAYS SAFE HAVENS IN UNDERGROUND COAL MINING Prepared for The Underground Coal Mining Safety Research Collaboration (UCMSRC) administered by NRCan-CANMET Mining Mineral Science Laboratories By DJF Consulting Limited Report: 3416-001.1 Date: 2003 December (finalized May 2004) The report has been prepared for UCMSRC. The report
Surface Coal Mining and Reclamation Act 9 . ARTICLE 21 . Oil and Gas Wells 11 Maintenance of Methane Detectors 176 . SERIES 22 . No Act Permitted Endangering Security of Mine; Search for Intoxicants, Matches, etc. 177 Rulemaking Procedures for the Board of Coal Mine Health and Safety 274 . SERIES 38
Underground coal mine lighting handbook. lines for system installation and maintenance. ment and work procedures encountered in coal mines. The primary objective of these reports is, therefore, to identify the major problems encountered in this lighting applica-
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When it comes to choose a color for flooring, one thing to look at first is the home design. If your home design theming your house in grey, for instance, grey vinyl flooring can be one of the best options for your house flooring so that you get inn-line home design.
Vinyl flooring is now popularly used among the homeowners and home designers. People with the low budget can consider installing vinyl flooring to complete the house establishment. Vinyl flooring proves to be cost-effective yet it comes with the high quality product and high durability. It can even last for ten years depending on the way you are maintaining it.
Many people tend to use vinyl flooring for its waterproof and water resistant, allowing it to suit the most crowded areas in the house such as hallways, bathroom, kids room and kitchen. Along with the proper installation, vinyl flooring can be easily attached to the floor and removed anytime you want to change.
Table of Contents
- Kind of Grey Vinyl Flooring
- Grey Vinyl Plank Flooring Ideas
- Grey Vinyl Tile Flooring Ideas
- Grey Vinyl Sheet Flooring Ideas
Kind of Grey Vinyl Flooring
Grey vinyl flooring is designed in many kinds of different colors, patterns and style. The combination of colors make the grey vinyl flooring look nice, allowing it to suit any home layout and wall color scheme. Below are the grey vinyl flooring variations you can have a look to find one that may be suitable with your interior.
Grey Wood Vinyl Flooring
Grey wood vinyl flooring comes with the wood look colored in grey. Installing this grey wood vinyl flooring will add an elegant look over your spaces. If the grey makes the room so pale, then the wood look add special accents to make it nice and make you feel peaceful.
Dark Grey Vinyl Flooring
Dark grey vinyl flooring is designed to sharpen the color of the space. Dark grey add a stronger effect and character to make your space looks nice. Dark grey vinyl flooring can best installed particularly when the walls and room layout are colored lightly. So, the interior design starts from the dark grey vinyl flooring to the light walls and lighter ceiling. This is a dark-to-light interior designs you may need to know.
Light Grey Vinyl Flooring
Other kind of grey vinyl flooring you may consider checking out is the light grey vinyl flooring. Some people like the light color to give the space a warm atmosphere. That's why, the light grey option is also produced by the manufacturer to meet the customer's need and expectation.
Grey Luxury Vinyl Flooring
If you want a more luxurious look of a grey vinyl flooring, here is the grey luxury vinyl flooring you can choose to install. This type of vinyl flooring is deigned to have a luxurious look along with the high durability, waterproof and water resistant feature. Thus, it comes not only with the look but also with the expected quality of vinyl flooring.
Brown and Grey Vinyl Flooring
Brown and grey are almost impossible to create a good color combination when they are united. However, brown and grey vinyl flooring creates a very good look within its design. Brown and grey vinyl flooring will make your spaces amazing without ignoring the main function of a vinyl flooring that is to provide the safety walk. The high durability and waterproof as well as water resistant features contribute much to create the best flooring for the most crowded areas in the house such as bathroom, kitchen and basement as well as laundry room.
Grey and White Vinyl Flooring
Grey and white are the colors that commonly look good to combine. For vinyl flooring, grey and white will bring a special visual effect to the room so that you can feel like you are enjoying your own world. Due to its good look, grey and white vinyl flooring is proper not only for the busiest rooms in your house such as kitchen, bathroom, kid's room and laundry room but also for the family room and even living room. It is because the grey and white vinyl flooring offers a soft and light sight, allowing everyone to feel calm when entering the room and walking on.
Grey Hexagon Vinyl Flooring
If you like a hexagon style in every parts around you, consider the grey hexagon vinyl flooring to add your love about hexagon style. In this case, hexagon style is considered as one of the most admired vinyl flooring design among the homeowners. Now you can get space looks like what you want with the grey hexagon vinyl flooring.
Grey Vinyl Plank Flooring Ideas
In relation with grey vinyl flooring you want to install, there are lots of grey vinyl plank flooring ideas you can search online and pick up for your house. Vinyl plank flooring is typically more proper to install on the basement, hallways and outer space such as terrace. Vinyl plank is easy to install as long as you know the proper way of installing it.
Grey Vinyl Tile Flooring Ideas
To make your interior complete with the desired design, grey vinyl tile flooring ideas can be taken into consideration. This way, the grey vinyl tile flooring is good for bathroom, laundry room, kitchens and even kid's bedroom.
Grey Vinyl Sheet Flooring Ideas
If you want the easier way of installing vinyl flooring, grey vinyl sheet flooring is a good idea to figure out. Just peel and stick the vinyl sheet on the floor and you will get your room amazingly transformed into your expected design.
Whatever types of vinyl flooring you choose from, either plank, tile of sheet, all of them come with their own durability and quality. Once you purchase grey vinyl flooring, make sure you follow the proper installation procedure based on the manufacturer recommendation. If you hire a home designer or an expert for installing the vinyl, well, it is more trustable and helping you get the better result. The cost-effective and a lifetime warranty makes the grey vinyl flooring is popularly used from time to time. Now what do you consider more?


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Idera Pharmaceuticals Initiates Phase 1 Clinical Trial of IMO-3100, a Toll-like Receptor Antagonist Intended for Autoimmune Disease Indications
- Details
- Category: DNA RNA and Cells
- Published on Thursday, 28 January 2010 02:00
- Hits: 1162
Idera Pharmaceuticals announced initiation of a Phase 1 clinical trial of IMO-3100, an antagonist of Toll-like Receptor (TLR) 7 and TLR9
CAMBRIDGE, MA, USA | January 28, 2010 | Idera Pharmaceuticals, Inc. (Nasdaq: IDRA - News) today announced initiation of a Phase 1 clinical trial of IMO-3100, an antagonist of Toll-like Receptor (TLR) 7 and TLR9.
"As an antagonist of TLR7 and TLR9, IMO-3100 has a novel mechanism of action and presents a potentially innovative approach in the treatment of a number of autoimmune diseases," said Sudhir Agrawal, D.Phil., Chief Executive Officer and Chief Scientific Officer. "IMO-3100 is our fourth compound to advance into clinical development, each for a different therapeutic application."
"Our first step in the clinical evaluation of IMO-3100 is to assess the safety and mechanism of action in healthy subjects," said Tim Sullivan, Ph.D., Vice President of Development Programs. "We have observed exciting results that show IMO-3100 ameliorates the pathologic findings observed in preclinical models of various autoimmune diseases, including lupus, rheumatoid arthritis, and psoriasis. Data from this Phase 1 clinical trial will support our decisions regarding subsequent clinical development of IMO-3100."
About IMO-3100
IMO-3100 is a DNA-based antagonist of Toll-like Receptor (TLR) 7 and TLR9, which has been shown in preclinical assays to suppress immune responses mediated through TLR7 and TLR9, including induction of interferon-alpha, TNF-alpha, IP-10, IL-6, and activation of B cells. Studies from independent researchers have suggested that immune complexes involved in certain autoimmune diseases induce inflammatory responses mediated through TLR7 and TLR9. Use of a TLR antagonist to block responses to such immune complexes may provide a potentially innovative approach for the treatment of autoimmune diseases. In preclinical mouse models of autoimmune diseases including lupus, rheumatoid arthritis, and psoriasis, IMO-3100 has shown potent activity in reducing pathologic and immunologic manifestations of disease. Idera continues to evaluate IMO-3100 and other TLR antagonist drug candidates in additional preclinical models of autoimmune, inflammatory, and hyperlipidemia diseases.
Idera has evaluated IMO-3100 for its pharmacodynamic mechanism of action in non-human primates. In this study, the ex vivo response of peripheral blood mononuclear cells (PBMCs) to TLR7 and TLR9 agonists was assessed at various times after subcutaneous administration of IMO-3100 to non-human primates. The Company plans to present data from this preclinical study at a scientific meeting in the first quarter of 2010.
About the Trial (Study 3100-001)
In this Phase 1 trial, IMO-3100 is being administered by subcutaneous injection to healthy subjects in a rising single-dose design. The primary objective is to evaluate safety and tolerability. Secondary objectives are to characterize the pharmacokinetic profile of IMO-3100 and to assess the pharmacodynamic mechanism of action through measurement of the ex vivo response of PBMCs to TLR7 and TLR9 agonists. The trial is being conducted at a single U.S. site.
The Company plans to use the results from this rising single-dose trial to select dosages for an anticipated follow-up trial in healthy subjects, the purpose of which would be to characterize safety, pharmacokinetics, and ex vivo pharmacodynamic mechanism of action with weekly subcutaneous administration for four weeks. Based on the data from these two planned Phase 1 trials, the Company intends to identify an autoimmune disease indication for further clinical development of IMO-3100 by the end of 2010.
About Idera Pharmaceuticals, Inc.
Idera Pharmaceuticals develops drug candidates to treat infectious diseases, autoimmune and inflammatory diseases, cancer, and respiratory diseases, and for use as vaccine adjuvants. Our proprietary drug candidates are designed to modulate specific Toll-like Receptors, which are a family of immune system receptors that direct immune system responses. Our pioneering DNA and RNA chemistry expertise enables us to create drug candidates for internal development and generates opportunities for multiple collaborative alliances. For more information, visit www.iderapharma.com.
SOURCE: Idera Pharmaceuticals, Inc.