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Edited by: Kiyoto Kasai, University of Tokyo, Japan
Reviewed by: Tsuyoshi Araki, University of Tokyo, Japan; Minah Kim, Seoul National University Hospital, South Korea
*Correspondence: Dean F. Salisbury,
This article was submitted to Schizophrenia, a section of the journal Frontiers in Psychiatry
†Present address: Sarah M. Haigh, Department of Psychology, University of Nevada - Reno, Reno, NV, United States
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Although "simple" mismatch negativity (sMMN) to stimulus parameter changes is robustly reduced in long-term schizophrenia (Sz), it is much less reduced in individuals at their first psychotic episode in the schizophrenia-spectrum (FESz). "Complex" MMN (cMMN) reflecting pre-attentive acoustic pattern analysis is also markedly reduced in Sz, but is little studied in FESz. The computational complexity of pattern analysis reflected in cMMN may more greatly stress auditory processing, providing a more sensitive measure of auditory processing deficits at first break. If so, cMMN would provide information about the underlying pathophysiology early in disease course, and may serve as a biomarker for pathology in the Sz prodrome. Twenty-two FESz individuals were compared to 22 volunteer healthy controls (HC) on sMMN and cMMN tasks. For sMMN, pitch- and duration-deviants were presented among standard repetitive tones. For cMMN, repeated groups of 3 identical tones were presented with occasional (14%) groups including an extra identical 4th tone deviant. FESz did not show reductions of pitch-deviant (Cohen's d = 0.08) or duration-deviant MMNs (d =-0.02), but showed large reduction in extra-tone cMMN (d = 0.83). Reduced cMMN was associated with poor social functioning. Reduction in cMMN but not in sMMNs in FESz suggests impairments in late perceptual pattern processing. cMMN is sensitive to subtle pathology and functioning early in disease course which may, in turn, impact social functioning. Future studies in clinical high risk individuals are needed to determine whether this putative biomarker of disease presence is sensitive to the prodromal stage of schizophrenia.
The auditory mismatch negativity (MMN), a neurophysiological measure related to automatic deviance detection, has engendered much research in clinical neuroscience to understand the basic pathophysiology of schizophrenia due to its severe impairment in long-term schizophrenia (Sz). The MMN elicited by infrequent changes in acoustic parameters, such as pitch-deviants (pMMN) and duration-deviants (dMMN), show effect sizes (Cohen's d) in Sz between 0.8 and 1.2 (
Like in FESz, sMMN reductions have been, at best, equivocal in clinical high risk for psychosis (CHR) individuals and in truly prodromal individuals within the CHR state. Despite some promising reports of greater dMMN reductions in CHR individuals that converted to psychosis (
Thus, sMMN reductions appear to be smaller in early psychosis. Given that sMMN is quite reduced in long-term illness, is related to the underlying circuit pathophysiology (
Healthy individuals produce MMN to a variety of deviants in complex patterns (hereby referred to as complex MMN; cMMN) including descending-pitch tone pairs among standard ascending-pitch tone pairs (
Complex auditory pattern analysis and cMMN have been examined in long-term illness. Alain et al (
Having validated complex auditory pattern protocols as eliciting reduced cMMN in long-term illness, we have begun testing them in FESz individuals. Although descending pitch deviants among ascending pitch paired tones showed reduced cMMN in long-term schizophrenia, tone-pair cMMN was within normal limits in FESz (
Although sMMN may not be highly sensitive to pathophysiology in early disease course, functional decline spans several domains (and predates the onset of overt psychosis). Keshavan and colleagues (personal communication, November 18, 2016)
Twenty-two FESz recruited from consecutive admissions to Western Psychiatric Institute and Clinic (WPIC) inpatient and outpatient services were compared with 22 healthy controls (HC). Fourteen FESz were diagnosed with schizophrenia (paranoid = 11, undifferentiated = 3), 2 with schizoaffective disorder (depressed subtype), 5 with psychotic disorder NOS, and 1 with schizophreniform disorder. FESz participated within two months of their first clinical contact for a first episode of psychosis, and had less than 2 months of lifetime antipsychotic medication exposure. Five FESz (22.7%) were unmedicated.
All subjects had normal hearing as assessed by audiometry, at least nine years of schooling, and an estimated IQ over 85. None of the participants had a history of concussion or head injury with sequelae, history of alcohol or drug addiction, detox in the last 5 years, or neurological comorbidity. Groups were matched for age, gender, premorbid estimates of intelligence based on the Wechsler Abbreviated Scale of Intelligence (WASI) IQ, and parental socioeconomic status. The 4-factor Hollingshead Scale was used to measure socioeconomic status (SES) in participants and in their parents. FESz evinced trend-level lower SES than HC, consistent with social and occupational impairment as a disease consequence (see
Demographic and clinical information.
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|22 (9)
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|23.6 (7.8)
|30.2 (13.1)
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|43.8 (13.7)
|49.5 (8.1)
|21.1 (4.8)
|17.6 (5.3)
|77.7 (14.5)
|1.7 (0.7)
|2.0 (0.6)
|124.9 (165.7)
SES, Socioeconomic status; PSES, Parental socioeconomic status; PANSSP, Positive and Negative Syndrome Scale positive factor score; PANSSN, PANSS negative factor score; PANSST, PANSS total score; SAPS, Scale for the Assessment of Positive Symptoms Averaged Global Scores; SANS, Scale for the Assessment of Negative Symptoms Averaged Global Scores; MEDS, Antipsychotic medication in chlorpromazine equivalents (oral dosages from Andreasen et al. (
Diagnosis was based on the Structured Clinical Interview for DSM-IV (SCID-P). Symptoms were rated using the Positive and Negative Symptom Scale (PANSS), Scale for Assessment of Positive Symptoms (SAPS), and Scale for Assessment of Negative Symptoms (SANS). All tests were conducted by an expert diagnostician (see
All participants completed the MATRICS Cognitive Consensus Battery and the WASI. Social functioning was assessed with the Global Assessment Scale (GAS), Global Functioning: Social and Role scales (GF:S, GF:R), the brief UCSD Performance-based Skills Assessment (UPSA-B) and the Social Functioning Scales (SFS, see
Neuropsychological and social functioning measures.
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|41.6 (12.0)
|48.4 (6.3)
|44.9 (14.6)
|45.5 (10.2)
|44.2 (12.2)
|51.8 (10.2)
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|82.6 (14.8)
|77.7 (9.7)
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|9.0 (0.1)
|100.6 (11.1)
|121.77 (22.3)
|110.7 (11.8)
|117.4 (5.4)
|114.9 (10.1)
|102.7 (12.0)
|109.7 (10.8)
Values are mean (sd). Significant p values are
EEG was collected while subjects underwent two passive auditory tasks. Stimuli were generated with Tone Generator (NCH Software), and presented in Presentation (Neurobehavioral Systems, Inc.). Binaural auditory stimuli were presented at 80 dB using Etymotic 3A insert earphones, with loudness confirmed with a sound meter. Participants watched a silent nature video while tones were played over earphones. They were asked to concentrate on the movie and ignore the tones.
Stimuli comprised a standard tone (1 kHz, 50 msec duration, 5 msec rise/fall), a pitch deviant (1.2 kHz, 50 msec duration, 5 msec rise/fall), and a duration deviant (1 kHz, 100 msec duration, 5 msec rise/fall), presented with a stimulus onset asynchrony of 330 msec. A total of 1600 tones were presented, including 1,280 standards (80%), 160 pitch deviants (10%), and 160 duration deviants (10%).
Temporal proximity was used to form discrete groups of tones, with a SOA within groups of 330 msec and an inter-trial interval of 750 msec. A total of 350 groups were presented. The standard group consisted of 3 identical tones (300 groups, 1 kHz, 50 msec duration, 5 msec rise/fall, identical to the standard tone in the simple MMN task). The deviant groups (50 groups, 14.3%) contained an additional fourth identical tone, and never immediately followed one another.
EEG was recorded from a custom 72 channel Active2 high impedance system (BioSemi), comprising 70 scalp sites including the mastoids, 1 nose reference electrode, and 1 electrode below the right eye. The EEG amplifier bandpass was DC to 104Hz (24 dB/octave rolloff) digitized at 512Hz, referenced to a common mode sense site (near PO1).
Processing was done off-line with EEGLAB (
Following pre-processing in EEGLAB, event-related potentials were processed using BrainVision Analyzer2. Data were low-pass filtered at 20 Hz to remove muscle and other high frequency artifact, and rereferenced to averaged mastoids.
Epochs of 350 msec, including a 50 msec prestimulus baseline, were extracted to deviant tones, and the standard tones preceding a deviant. Epochs were DC detrended between the first and last 50 msec, baseline corrected, and subsequently rejected if any site contained activity ±50 μV. Averages were constructed for the standard tones preceding a deviant, pitch deviants, and duration deviants. Pitch MMN (pMMN) was visualized by subtracting the standard average from the pitch deviant average. Duration MMN (dMMN) was visualized by subtracting the standard average from the duration deviant average. MMN was measured by detection of the peak MMN at FCz in the group grand averages, and voltage then averaged over a 25 msec window centered on that latency for each individual at 6 frontocentral sites (F1, Fz, F2, FC1, FCz, FC2) where cMMN was largest (pMMN: FESz 95–120 msec; HC(FE) 95–120 msec; Sz 95–120 msec; HC(Sz) 97–122 msec, dMMN: FESz 158–183 msec; HC(FE) 162–187 msec; Sz 168–193 msec; HC(Sz) 156–181 msec).
Epochs of 750 msec were extracted, including a 100 msec prestimulus baseline. All epochs were DC detrended between the first and last 50 msec, baseline corrected, and subsequently rejected if any site contained activity ±50μV. Averages were constructed for the standard group last tones and the deviant group extra tones. cMMN was visualized by subtracting the standard group ending tone average from the deviant extra fourth tone average. MMN was measured by detection of the peak latency of the late cMMN at FCz in the group grand averages, and voltage then averaged over a 25 msec window centered on peak latency for each individual at the 6 frontocentral sites. Due to the apparent early and late MMNs, two time periods were analyzed; early cMMN (130–155 msec for all groups), and late cMMN (430–455 msec for all groups).
Group demographics and neuropsychological scores were compared using t-tests and chi-squared tests where appropriate. MMN analyses utilized repeated-measures ANOVA, with group (FESz, HC) as the between subjects factor, and electrode chain (F or FC) and site (left, central, or right) as within subjects factors. The Huynh-Feldt epsilon was used to correct for potential violations of sphericity of the site factor. Effect sizes were calculated as Cohen's d at FCz, the difference between the group means expressed in pooled standard deviations. Two-tailed Spearman's correlations were used to examine relationships between MMN at FCz and demographic, clinical, and neuropsychological items. Values are reported as Mean ± SD. Significance was attained at p < .05.
pMMN was not reduced in FESz (F1,42 = 0.2, p = .657,
Pitch deviant mismatch negativity (MMN) in first psychotic episode in the schizophrenia-spectrum (FESz) and healthy control (HC) (arrow). Note that FESz are well within the normal range in pMMN at the group level.
Simple mismatch negativity (sMMN) and complex MMN (cMMN) values.
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Values are mean (SD). Values are in μV.
dMMN was not reduced in FESz (F1,42 = 0.001, p = .976,
Duration deviant mismatch negativity (MMN) in first psychotic episode in the schizophrenia-spectrum (FESz) and healthy control (HC) (arrow). Note that FESz are well within the normal range in pMMN at the group level.
The early cMMN was not different between groups (p > .2) and will not be discussed further. Unlike pMMN and dMMN, which were not reduced, late cMMN (henceforth referred to as cMMN) was significantly impaired in FESz (FESz: -0.1 μV, HCFE: -1.2 μV. F1,42 = 6.2, p = .016.
Extra tone gestalt grouping rule complex mismatch negativity (MMN) in first psychotic episode in the schizophrenia-spectrum (FESz) and healthy control (HC). Note the lack of late cMMN in FESz (arrow).
There were no significant correlations in FESz between cMMN amplitudes and WASI or MATRICS composite scores. Likewise, there were no significant correlations with PANSS total scores or positive, negative, or thought disorder factor scores. Among social functioning measures, larger cMMN was associated with higher SFS independence-performance scaled scores (r = -.54, p = .009,
Correlation of complex mismatch negativity (cMMN) with Social Functioning Scales Independence-performance scaled scores. Independence-performance measures the use an attained skill for successful social functioning. Hence, lower scores indicate the failure to use an available skill, rather than a lack of social skills per se. Note that among first psychotic episode in the schizophrenia-spectrum (FESz) smaller cMMN is a reliable index of a failure to successfully utilize one's full set of social skills. Note: cMMN measured from FCz.
In this sample of individuals at first contact with psychiatric services for psychosis, with only a short course of antipsychotic medication, sMMN was not reduced at the group level, with a small effect size for both pMMN (d =0.08) and dMMN (d =-0.02). By contrast, the later cMMN to a pattern deviant, in this case an extra 4th tone among groups of 3 tones, revealed a significant and large deficit (d =0.82). Thus, the results are consistent with the hypothesis that the increased computational demand of pattern processing as reflected in cMMN by contrast with the relatively easily discriminable physical parameter changes eliciting sMMN is more sensitive to the earlier and more subtle pathophysiology during the early course of the progressive pathology in schizophrenia. Although the exact neural correlates of the cMMN are unknown, it is assumed the same circuits process novelty for sMMN and cMMN within the prediction error scheme (
cMMN was not significantly different from zero in FESz. Hence, it is not entirely clear if correlations are valid, in the sense that the cMMN may only reflect neurophysiological noise. However, FESz did show a range of cMMN amplitudes (
The fact that cMMN was not significantly different from zero in FESz argues strongly for its utility as a biomarker of disease presence. This is even more compelling in the context of an essentially normal pMMN and dMMN in the same FESz subjects that showed a markedly impaired cMMN. Thus, it appears that pattern-deviance tasks that necessitate a higher level of processing may be more sensitive to subtle auditory cortex pathology than relatively simple changes in a single acoustic feature. One might speculate that the degree of pathology needed to impair detection of pure tone differences is rather substantial. cMMN appears to be sensitive to more modest pathology. Future studies should compare first episode schizophrenia-spectrum to affective-spectrum individuals to determine the specificity of the cMMN deficit on this task.
Although CHR individuals were not tested, we suggest a measure with a large deficit in FESz may be useful for investigation of CHR individuals. While all CHR individuals may show general auditory pathology, it is possible that the cMMN deficits emerge only in those that are in the true prodrome to schizophrenia. While no single test is likely to be diagnostic, the extra tone cMMN appears to be an important tool that when used in conjunction with other biological, neuropsychological, and clinical measures can provide an objective indication of risk for transition to psychosis. It is important to note that most "risk calculators" for transition to psychosis and studies of factors predisposing to eventual conversion are based on clinical and psychological rather than biological aspects of presentation. For example, Cannon et al. (
By contrast with the clinically-based risk calculators, a growing number of studies explored baseline and longitudinal measures useful in predicting group membership once transition to psychosis occurred (or more correctly over a followup period such as 2, 3, or 5 years). In their recent meta-analysis, Studerus, Ramyead, and Riecher-Rössler (
Several issues remain unanswered. Although the effect size for cMMN reduction was large (d = 0.82), the samples were relatively modest, and the results must be replicated. Because this is the first application of the extra tone cMMN task at first episode, and there are relatively few cMMN studies in psychosis, the reliability of the measure is unknown. The cMMN was small in HC, which may limit its utility. Currently, we are developing new pattern MMN paradigms to elicit larger cMMN in HC, which presumably will increase the group separation. We do not know whether the cMMN and sMMN share the same biological substrate, particularly given the longer latency of cMMN. Neither do we know what the distributed neural system underlying cMMN is. Relatedly, we do not know whether cMMN is dependent on NMDAr function. Future work must resolve these molecular issues. It is not known what cMMN looks like in CHR. A robust decrement in cMMN at first episode in the lack of sMMN reduction indicates that the probability of cMMN providing useful information about subtle underlying neural pathophysiology in true prodromal cases among CHR individuals is greater than sMMN. Still, it remains unknown. Currently, we are testing this paradigm in such individuals.
In summary, we showed that cMMN to an extra tone among frequent groups of standard size was reduced in FESz, while pMMN and dMMN were not. Further the cMMN correlated with social functioning, with worse functioning associated with smaller cMMN. These novel data provide the first step in development of a MMN-based task that is more sensitive to the subtle pathology early in the course of schizophrenia. We speculate that cMMN may be a useful probe of pathophysiology in the true psychosis prodrome.
The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation, to any qualified researcher.
The studies involving human participants were reviewed and approved by University of Pittsburgh Institutional Review Board. The patients/participants provided their written informed consent to participate in this study.
DS provided substantial contributions to the conception and design of the work; the acquisition, analysis, and interpretation of data for the work; and drafting the work and revising it critically for important intellectual content. BC provided substantial contributions to the acquisition, analysis, and interpretation of data for the work, and revising the report critically for important intellectual content. SH provided substantial contributions to the acquisition, analysis, and interpretation of data for the work, and revising the report critically for important intellectual content. All authors provided approval for publication of the content, and agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
This work was supported by NIH R01 MH094328 to DS.
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
We thank Timothy K. Murphy, BS, Kayla Ward, BS, and Justin R. Leiter-McBeth, BA, for data acquisition and analysis, and the faculty and staff of the WPIC Psychosis Recruitment and Assessment Core, the Conte Center for Translational Mental Health Research (P50 MH103204, David Lewis, MD, Director), and the University of Pittsburgh Clinical Translational Science Institute (UL1 RR024153, Steven E. Reis, MD) for their assistance in recruitment, diagnostic and psychopathological assessments, and neuropsychological evaluations of participants.
At the Annual Pittsburgh Schizophrenia Conference.


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Tag: Social Distancing
Special get together for veterans
Editorial Team — August 10, 2020 comments off
ON THE 75th anniversary of VE Day in May, three local Second World War veterans were given a platter of food each and a promise. "We will meet again after this painful... Read more »
Annual Hiroshima commemoration to be held online
Editorial Team — August 7, 2020 comments off
AN ANNUAL commemoration of the first use of nuclear weapons in war is being livestreamed on the internet this year, rather than being held in public, because of COVID-19 restrictions. Woking Action... Read more »
Brooklands Museum finds new ways to welcome back visitors
Editorial Team — July 31, 2020 comments off
BROOKLANDS Museum's historic vehicle and aircraft collections open to the public again on Saturday, with visitors required to book timed-entry tickets in advance. The museum, ranged across 32-acres of the former aircraft... Read more »
Village pub adds welcome cheer to cricket club
Editorial Team — July 28, 2020 comments off
NOTHING says "English summer" quite like a pint of beer while watching cricket and the two have come together in Chobham. The village's White Hart pub has set up a marquee on... Read more »
Medal wins at first virtual rowing championships
Editorial Team — July 27, 2020 comments off
LOCAL pair Teddy Gannon and James Gibson won three medals between them at the maiden British Rowing Virtual Championships. Woking High School pupil Gannon, competing for Guildford Rowing Club, won the Year 9... Read more »
Outdoor gymnastic classes for all the family
Editorial Team — July 25, 2020 comments off
A GYMNASTICS club aimed at families is picking up new members since moving from a village hall to the field outside to comply with social distancing. Springbox and Springtots has been running... Read more »
Active Surrey issues safety advice as gyms prepare to reopen
Editorial Team — July 21, 2020 comments off
WITH gyms, leisure centres and indoor swimming pools ready to reopen at the end of this week, advice has been issued for staying safe while getting back to "normal" forms of exercise.... Read more »
On your bike for cycling with cake
Editorial Team — July 15, 2020 comments off
WOKING residents who have recently taken up cycling are being urged to join their local club. Woking Cycling Club has regular weekend group rides that have been suspended during the coronavirus lockdown.... Read more »
Woking Park Bowls Club back on the green
Editorial Team — July 8, 2020 comments off
WOKING Park Bowls Club has reopened after lockdown restrictions were eased. The club, which was founded in 1914, welcomed its 70 members back after the Government and Woking Borough Council agreed that... Read more »
Bowls club members can 'roll up' again
Editorial Team — June 26, 2020 comments off
WESTFIELD Cricket and Bowls Club has reopened its Greenmeads ground to members after the easing of lockdown restrictions. The historic club was given the green light after government guidance, implemented by Bowls... Read more »

subset: commoncrawl


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Les verbes r flexifs 1 – les verbes pronominaux – reflexive verbs
2 years ago
This video is in French and explains the concept of reflexive verbs versus regular verbs and explains also the "each other" concept as well as how to conjugate …
Student pricing tip -
Any item including new computers - Gaming, School, Laptops, Desktops - when clicking on links - scroll page for lowest prices - look at all offers - More Buying Choices - used & new offers. Often the new offers are less than price shown. When you choose type of computer, if it only gives one listing, copy & paste computer name in search box, often you'll find other vendors listing same computer for less money


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Link to this page: https://secure.socialistparty.org.uk/articles/14504
Posted on 11 May 2012 at 11:06 GMT
NUT Executive "shirks its responsibilites"
Martin Powell-Davies, a Socialist Party member who is on the national executive committee of the National Union of Teachers (NUT) has posted on his blog a report of yesterday's NUT executive meeting and the executive's attitude to further action on pensions.
May 10 strike - united to defend pensions
Donate to the Socialist Party
Coronavirus crisis - Finance appeal
The coronavirus crisis has laid bare the class character of society in numerous ways. It is making clear to many that it is the working class that keeps society running, not the CEOs of major corporations.
The results of austerity have been graphically demonstrated as public services strain to cope with the crisis.
The government has now ripped up its 'austerity' mantra and turned to policies that not long ago were denounced as socialist. But after the corona crisis, it will try to make the working class pay for it, by trying to claw back what has been given.
- The Socialist Party's material is more vital than ever, so we can continue to report from workers who are fighting for better health and safety measures, against layoffs, for adequate staffing levels, etc.
- Our 'fighting coronavirus workers' charter', outlines a programme to combat the virus and protect workers' living conditions.
- When the health crisis subsides, we must be ready for the stormy events ahead and the need to arm workers' movements with a socialist programme - one which puts the health and needs of humanity before the profits of a few.


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Beautifully situated, affordable one-story home in attractive Double Diamond Ranch. Home is newly painted. Home backs to Double Diamond Ranch common area with no rear neighbors. This nicely landscaped east-oriented backyard with good patio is perfect for summer entertaining. Large storage shed in yard. Great proximity to Double Diamond Ranch, Veterans Parkway, and Damonte Ranch trail system and parks, schools, and shopping.
Courtesy of Kenneth Lund and Ferrari-Lund Real Estate South.
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Data last updated on 06/28/2017.
The data relating to real estate for sale on this web site comes in part from the Broker Reciprocity Program of the Northern Nevada Regional MLS. Real estate listings held by brokerage firms other than owner of this page are marked with the Broker Reciprocity logo and detailed information about them includes the name of the listing brokers.
Information deemed reliable but not guaranteed


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chl hub.
Over a 6 month period, CHL carried out research to find out more about young creatives and your journeys/experiences in navigating the creative sectors.
200+ of you were interviewed, surveyed & contributed to our research in one way or another. Thanks to you, we were able to gather relevant insight on how we could all access and disrupt the ever changing creative landscape.
On average, you asked for more collaboration. Amongst young creatives & between young creatives and brands.
We listened, and CHL Hub was born.
It's our way of giving back.


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Search Engine Land defines SEO as "…the process of getting traffic from the 'free,' 'organic,' 'editorial' or 'natural' search results on search engines." Essentially, SEO is the process of optimizing your website through various methods in order to rank higher for certain relevant keywords on search engines like Google, Bing, and Yahoo. With effective SEO, your website will appear higher on search engine results pages (SERPs) due to its positive relationship to that search engine's particular ranking algorithm.
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Famed Watergate journalist Carl Bernstein said in a Sunday television interview that President TrumpDonald John TrumpLincoln Project ad dubs Jared Kushner the 'Secretary of Failure' Pence: Chief Justice Roberts 'has been a disappointment to conservatives' Twitter bans Trump campaign until it deletes tweet with COVID-19 misinformation MORE's tenure in the White House has been "characterized" by Trump's lying.
"There's no reason to believe almost anything Donald Trump says," Bernstein told CNN's "State of the Union" when asked about the administration's promise not to fire special counsel Robert MuellerRobert (Bob) MuellerCNN's Toobin warns McCabe is in 'perilous condition' with emboldened Trump CNN anchor rips Trump over Stone while evoking Clinton-Lynch tarmac meeting The Hill's 12:30 Report: New Hampshire fallout MORE.
"Because what we know is that the president of the United States and his presidency is characterized above all else by the lying of the president of the United States."
Trump said earlier this month that he is not considering firing Mueller, who is leading the probe into Russia's election meddling and any potential ties between Trump campaign staff and the Kremlin.
Bernstein, who broke the Watergate scandal during the presidency of Richard Nixon, said, however, that Trump's lies do not necessarily constitute a crime.
"That doesn't mean that lying by the president is a crime," he said.
"It does mean that we see him covering up events, but not necessarily criminally covering up events. And where this is going, definitively, we don't know."
Bernstein added that White House officials have told him that Trump has conveyed "the desire to fire Mueller."


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During Thanksgiving break, Ms. Dozois' students entered a design competition sponsored by Questlove and the Adobe Corporation. The challenge was to create a visual design for an inspirational quote.
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You can also see the winning work on the website, here: https://project1324.com/challenge/creativequotes


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Times of India: Ahmedabad: Wednesday, April 20, 2016.
Gujarat government announced on Tuesday that no Value Added Tax (VAT) will be imposed on salt unit owners with plots smaller than 10 acres. The state government has also granted exemption from paying 5 % VAT to salt producers who have been given land on lease. Besides, exemption has also been given to producers of domestic salt. Agariyas (salt workers), however, say their lives would now be under the thumb of the salt inspector, and they will not be able to prepare accounts, as they are mostly illiterate. The salt-panners' association has demanded total roll back on the VAT on salt comparing it with the tax imposed by British Raj.
A press statement issued by finance minister Saurabh Patel said that the state government has decided to exempt small salt panners from the 5 % VAT announced in the budget for the current financial year.
"The state government has decided to give exemption from paying 5% VAT on salt produced by salt producers owning plots of 10 acre or less. Besides, the salt pan workers who have been given land on lease by the state government will also be exempted," said the statement.
Salt pan workers who are selling salt only for domestic purpose will also be exempted, reads the statement.
Bharat Somera, a salt pan worker from Meetha Ghoda village of Surendranagar district, sa id that this exemption will not help salt pan workers much as they have to prepare accounts to show to salt inspectors. "Most of the Agariyas (salt pan workers) are illiterate and cannot prepare such accounts," he said.
Bachubhai Ahir, spokesperson of Namak Satyagrah Samiti, said that the new provision of recovering VAT by the Gujarat government is alike the tax imposed on salt by the Britishers. "The new provision will bring inspector raj in the salt industry. If the salt inspector decides our fates, then we will face huge difficulties," he said.
Harinesh Pandya, activist, said that the salt industry needs the state's support at a time when it is facing tough competition from the Chinese market. Instead of supporting the salt industry , the state government is levying VAT on them.


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This hotel is located in the BoCoCa neighborhood, 1585 feet from the subway station. It offers free WiFi and a 24-hour gym. All air conditioned rooms at the NU Hotel feature 32-inch flat-screen cable TVs with satellite music systems. These rooms have private bathrooms and bath amenities. Hotel NU offers business workstations for guests' convenience. The NU Bar serves continental breakfast daily along with a tapas menu and full-service bar in the evenings.Free bike rentals are also offered. NU Hotel is 2113 feet from the Brooklyn Borough Hall. Barclay Center is 0.8 mi away.
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Cardiac Drugs in Pregnancy pp 11-34 | Cite as
Management of Hypertension
- 1.2k Downloads
High blood pressure affects about 10 % of pregnancies worldwide (Duley 2009), and is the second-most frequent cause of maternal death (Khan et al. 2006). The most serious form of pregnancy hypertension is pre-eclampsia, a progressive multisystem disorder only curable by delivery of the infant. Pre-eclampsia is found in about 2–8 % of pregnancies (Duley 2009), with 5–8 % of pre-eclamptic women in less-developed countries going on to eclamptic convulsions (World Health Organization 2011). Other complications of pre-eclampsia include intracerebral haemorrhage, pulmonary oedema, liver rupture, placental abruption, fetal growth restriction, and HELLP (haemolysis, elevated liver enzymes, low platelets) syndrome.
KeywordsSevere Hypertension Fetal Growth Restriction Magnesium Sulphate Gestational Hypertension HELLP Syndrome
- Abalos E, Duley L, Steyn DW, Henderson-Smart DJ. Antihypertensive drug therapy for mild to moderate hypertension during pregnancy. Cochrane Database Syst Rev. 2007;1:CD002252.Google Scholar
- Ahmed A. New insights into the etiology of preeclampsia: identification of key elusive factors for the vascular complications. Thromb Res. 2011;127 Suppl 3:S72–5.PubMedCrossRefGoogle Scholar
- American Academy of Pediatrics Committee on, Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001;108:776–89.Google Scholar
- American College of Obstetricians and Gynecologists. ACOG practice bulletin. Diagnosis and management of preeclampsia and eclampsia. Number 33, January 2002. Obstet Gynecol. 2002;99:159–67.CrossRefGoogle Scholar
- Beardmore KS, Morris JM, Gallery ED. Excretion of antihypertensive medication into human breast milk: a systematic review. Hypertens Pregnancy. 2002;21:85–95.PubMedCrossRefGoogle Scholar
- Bullo M, Tschumi S, Bucher BS, Bianchetti MG, Simonetti GD. Pregnancy outcome following exposure to angiotensin-converting enzyme inhibitors or angiotensin receptor antagonists: a systematic review. Hypertension. 2012;60:444–50.PubMedCrossRefGoogle Scholar
- Duley L. The global impact of pre-eclampsia and eclampsia. Semin Perinatol. 2009;33:130–7.PubMedCrossRefGoogle Scholar
- Duley L, Henderson-Smart DJ, Meher S. Drugs for treatment of very high blood pressure during pregnancy. Cochrane Database Syst Rev. 2006;3:CD001449.Google Scholar
- Duley L, Gulmezoglu AM, Henderson-Smart DJ, Chou D. Magnesium sulphate and other anticonvulsants for women with pre-eclampsia. Cochrane Database Syst Rev. 2010;11:CD000025.Google Scholar
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- James MF. Magnesium in obstetrics. Best Pract Res Clin Obstet Gynaecol. 2010;24:327–37.PubMedCrossRefGoogle Scholar
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- Koopmans CM, Bijlenga D, Groen H, Vijgen SM, Aarnoudse JG, Bekedam DJ, van den Berg PP, de Boer K, Burggraaff JM, Bloemenkamp KW, Drogtrop AP, Franx A, de Groot CJ, Huisjes AJ, Kwee A, van Loon AJ, Lub A, Papatsonis DN, van der Post JA, Roumen FJ, Scheepers HC, Willekes C, Mol BW, van Pampus MG, HYPITAT Study Group. Induction of labour versus expectant monitoring for gestational hypertension or mild pre-eclampsia after 36 weeks' gestation (HYPITAT): a multicentre, open-label randomised controlled trial. Lancet. 2009;374:979–88.PubMedCrossRefGoogle Scholar
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The federal government has rejected a mining exploration program by Perth-based CI Resources on Christmas Island that would have extended the company's existing phosphate operations by up to 10 years.
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All praise be to Allah, and peace and blessings be upon the most honorable among Prophets and Messengers, our Prophet Muhammad, and upon his family and companions. To proceed:
I have the honor to be a colleague of my brother staff of the College of Health Sciences in Al-Leith, working with them to uplift the college, both academically and administratively, in the desired manner that meets the aspirations of its officials and employees in general as well as the ongoing transformation the university is witnessing, according to its plans and regulations.
I consider that the most important tasks of the Director of the College is to provide everything possible to serve and facilitate matters for the students, faculty and administrative staff, within the limits of his powers and tasks. This is in order to be an effective and positive managerial member of the college, being aware of his national duties towards all those he deals with during the course of his work.
I do not exaggerate when I say that I am honored to serve the students and faculty; my office should become a relations and services office, eliminating all the difficulties that stand before them, for them to always be optimistic, hoping for a bright and promising future. Let their slogan be, "Smile, you are in the College of Health Sciences in Al-Leith". We should all cooperate towards achieving the national goals, an effort which everyone is honored to take part in.


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- Innovative
Even as former US vice president Al Gore catalogs the devastating effects of global climate change, he provides cause for hope. Installations of renewable energy sources such as wind and solar are going up as costs go down. The investment community has taken notice, pouring money into this exciting opportunity. Yet curbing the tide requires cooperation among nations in support of Earth's citizens. getAbstract highly recommends this elucidating talk by the author of An Inconvenient Truth.


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text: How true are your wheels? Forums › Mountain Bike Forum › How true are your wheels? --SHARES Tweet Add to Flipboard Magazine. Tagged: mtb wheels, true wheels, wheel truing, wheels Viewing 10 reply threads Author Posts July 7, 2019 at 7:40 pm #265446 vapidoscar With disk brakes, it doesn't matter as much but my new wheels are already slightly out of true. I'm curious about two things: How true are your wheels? Perfectly true Slightly out of true Noticeably out of true Untrueable (dinged, bent, etc. How do you true your wheels? Do-it-yourself Take to shop Ignore until tire rubs the frame July 7, 2019 at 8:55 pm #265449 ZipHead 1) Perfectly true 2) I do it myself. Spoke wrench & zip-ties. 5 buck investment. July 8, 2019 at 8:52 am #265452 Phonebem Perfectly true. When I re-tape rims or change tires I throw the wheels on my truing stand. Otherwise I go with the zip tie method. July 8, 2019 at 10:45 am #265459 Bike Nerd I've had rims that stayed perfectly true for the entire life of the bike. And I've had rims that needed to be trued yearly. However, most of my bikes have wheels that are just slightly out of true and I just leave them that way until they are noticeably out of true. When they get to that point, I get them trued at the shop. In my experience, the narrower the rim, to more likely it needs to be trued. I don't think that I've ever had to true a rim that was inner width i30mm or wider. July 14, 2019 at 7:29 pm #265920 abegold True, as I'm 140 pounds nothing on the bike gets stressed. Everything is built for heavier riders. July 15, 2019 at 9:14 am #265971 Dr Sweets Perfectly true. Mostly do it myself, however I've ran heavy duty carbon wheels for the last four years and they rarely need any truing. July 15, 2019 at 11:06 am #266041 Head Over Handlebars Both wheels are slightly out of true and dented. There's a reason I don't get expensive carbon wheels. If they get really bad and need to be trued I'll take them to the shop. July 15, 2019 at 10:19 pm #266086 Oldandrolling Slightly out of true. I do it myself with the zip tie method. I usually check my wheels twice a year and make any necessary adjustments July 17, 2019 at 6:59 pm #266329 rmap01 Love the question. Mine are slightly out of true. If they get any worse I'll have them trued the next time I need to bring the bike in to the shop. Before I swapped out my stock rims on my XC bike the wheels needed to be trued 3-4x per year and I was set on learning how to do it myself. But after I upgraded my wheels I find that they only need to be trued about once per year so I don't have the same motivation I did previously. And since I usually take my bike in to the shop at least once a year anyway I just ask them to true it when I'm there. July 18, 2019 at 10:15 am #266337 charding My front wheel is true and my rear wheel is slightly out. I take it to the shop, but I'm slowly learning and adding bike knowledge and tools, so I hope to figure out how to do this for myself eventually. July 21, 2019 at 6:50 pm #266449 fjoksls 1) Perfectly true 2) I do it myself. Spoke wrench & zip-ties. 5 buck investment. Author Posts Viewing 10 reply threads RELATED TOPICS Topic Voices Posts Freshness How true are your wheels? Started by: vapidoscar in: Mountain Bike Forum 11 11 1 year ago fjoksls My first solo Maah Daah Hey bikepacking trip Started by: stumpyfsr in: Mountain Bike Forum 4 7 3 years, 11 months ago stumpyfsr A suggestion for coexisting with E-bikes: cheap, simple traction control Started by: tim.hillsamer in: Mountain Bike Forum 4 10 4 years ago schwim 9 New Mountain Bikes That Blew Us Away! Started by: DayInTheLife in: Mountain Bike Forum 2 4 4 years, 3 months ago ZipHead Newbie question Started by: Jim Kyle in: Mountain Bike Forum 2 2 4 years, 5 months ago Aaron Chamberlain You must be logged in to reply to this topic.


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by mtuandrew
Scheduled Nov 26-Dec 9, so if anyone transfers at Pentagon... be prepared for a hell of a commute for a while.
Moderator: General Discussion: Passenger Rail,
DC-MD-VA Passenger Rail and Amtrak
DC-MD-VA Passenger Rail and Amtrak
Railroad Forums
Moderators: mtuandrew, therock, Robert Paniagua
WTOP track work guide: Yellow Line shutdown from Nov. 26 to Dec. 9Look for express buses from Franconia-Springfield to Pentagon and from Pentagon to L'Enfant to help ease congestion.
By Max Smith | @amaxsmith
November 25, 2018 4:57 am
WASHINGTON — Metro's Yellow Line falls off the map for two weeks starting the Monday after Thanksgiving (Nov. 26) as the transit agency shuts down the bridge over the Potomac River for repairs.
The work is scheduled to cut rush-hour rail service in half at all Blue and Yellow Line stations in Virginia from Pentagon to Franconia-Springfield and Huntington, and in the District at Yellow and Green Line stations between L'Enfant Plaza and Mt. Vernon Square.
Metro plans to run every other normally scheduled rush hour Blue Line train from Huntington rather than Franconia-Springfield at rush hour, providing trains every 16 minutes from each endpoint.


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USA: Promar: Organic labeling won't hurt and should help
The new organic labeling standards hinted at by the U.S. Department of Agriculture bode well for food and beverage manufacturers, says consulting firm Promar International. ``Secretary Glickman's recent comments are good in two ways,'' notes Promar VP Don Westfall. ``Most importantly, the standards will help provide uniformity and credibility for the expanding US organic market. In addition, the standards should reassure mainstream manufacturers that organic foods would not be presented as having inherently superior nutrition and health benefits as compared to processed foods.''
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India's dissent over China's BRI poses no threat to SCO: Secretary-General Norov
Beijing-headquartered Shanghai Cooperation Organisation (SCO) is an eight-member economic and security bloc. India and Pakistan were admitted into the grouping in 2017. Its founding members include China, Russia, Kazakhstan, Kyrgyzstan, Tajikistan and Uzbekistan.
'Pakistan continues to promote terror notwithstanding pandemic'
Pakistan's Prime Minister had also publicly acknowledged presence of up to 40...
Shanghai Cooperation Organisation states favour action plan by leaders to fight Covid-19
The SCO states agreed on a joint declaration that fo...
Pakistan must introspect why it's universally acknowledged as 'epicentre' of terrorism: India
Mahaveer Singhvi, head of the Indian delegation, made the comments at a webinar 'The Global Scourge of Terrorism: Assessment of High-Risk Threats and Trends, including the rise of Violent Extremism and Hate Speech in a Pandemic Environment' on Tuesday during the ongoing virtual Counter-Terrorism Week.
Pakistanis head terror groups ISIL-K, AQIS, TTP; not yet blacklisted: UN report
Al-Qaida in the Indian Subcontinent (AQIS) operates under the Taliban umbrella from Afghanistan's Nimruz, Helmand and Kandahar provinces and its current leader is Pakistan-born Osama Mahmood, who is also "not listed" under the UNSC sanctions. Mahmood succeeded Asim Umar.
S Jaishankar, Wang Yi may take part in SCO, BRICS meets in Russia in September
The meeting of SCO foreign ministers is being planned on September 9-10 and BRICS foreign ministers are also expected to meet around the same dates, sources said.
Suspended J&K DSP Davinder Singh gets bail in terror case
Suspended Jammu and Kashmir DSP Davinder Singh, arrested while ferrying two Hizb-ul-Mujahideen terrorists in a vehicle on the Srinagar-Jammu Highway earlier this year, was granted bail by a Delhi court on Friday.
NIA arrests bank manager who was key operative of narco-terror module in Jammu & Kashmir
Afaq Ahmad Wani, a resident of Maratgam village of Handwara, is the fourth person to have been arrested after the drug syndicate operating in Jammu and Kashmir was busted last month. It led to the seizure of 21 kg of heroin and over Rs 1.35 crore in cash from the syndicate members.
Pakistan's counter-terrorism steps important but not irreversible: US
Noting that the US considers Pakistan, a nuclear-armed country of 200 million population, as an important partner, she said that the Trump administration is not blind to the cross-cutting issue of terrorism.
US court rejects bail plea of 26/11 accused Tahawwur Rana being sought by India
Rana, 59, a childhood friend of David Coleman Headley, was re-arrested on June 10 in Los Angeles on an extradition request by India for his involvement in the 2008 Mumbai terror attack in which 166 people, including six Americans, were killed.
UN report vindicates our stand on Pakistan sponsored terror: India
"This vindicates India's long standing position that Pakistan remains the epicentre of international terrorism," MEA Spokesperson Anurag Srivastava has said.
Indian-origin S African appointed COO of company assisting in combating organised bank-related crimes
The South African Banking Risk Information Centre (SABRIC) was formed by the country's major banks like the First National Bank and the Standard Bank. Besides assisting in combating organised bank-related crimes, SABRIC also keeps people informed about the latest banking scams and fraudster activity.
Pak-origin Canadian rearrested in US on India's extradition request for role in Mumbai terror attack
Rana, 59, a childhood friend of David Coleman Headley, was recently released from jail on compassionate ground after he told a US court that he has tested positive for the COVID-19. Assistant US Attorney John J Lulejian told the court that the Indian government, as per the bilateral Extradition Treaty signed in 1997, has requested the arrest and detention of Rana with a view towards his extradition.
Suspended J&K DSP Davinder Singh gets bail in terror case as police fails to file charge sheet
Singh and another accused in the case Irfan Shafi Mir were granted the relief by Special Judge Dharmender Rana in the case filed by the special cell of Delhi police, who noted that it failed to file the charge sheet within 90 days from their arrest, as prescribed under the law.
India's UNSC priorities find 'resonance' in declaration to commemorate UN's 75th anniversary
The declaration outlines the priorities of the world organisation and calls for greater action and international cooperation to meet varied global challenges in the years ahead.


text:
Venice to Utah
Italy - Morocco - Dominican Republic - Turks and Caicos - USA
February 16 - March 2, 2021Read More
Beachcombing and sunbathing are the top two things to do at the Esplanade, Miri's beach scene at Luak Bay. Another good beach is Taman Selera, where visitors can enjoy a picnic or sunset cocktails.
Those interested in the development of the oil industry in Southeast Asia will enjoy Canada Hill. This is Malaysia's very first oil well and it stayed operational between 1910 and the second administration of President Richard Nixon. There's a Petroleum Museum here and spectacular views of the South China Sea.
City Fan has gardens and the biggest open-air amphitheater in all of Malaysia. There is also plenty of opportunity for swimming, running, aerobic workouts and other outdoor activities.
About 15 miles south of Miri is the Lambir Hills National Park, which is a rainforest complete with waterfalls and special sections where visitors can enjoy a picnic. Make sure to plan a trek, hike or photography outing while bringing along a specially prepared meal for a picnic.
Go diving off Miri and enjoy an unspoiled coral reef. Try your hand at underwater photography.
Mainland China provided the genesis for the Taoist San Ching Tian Temple, the largest of its kind in all of Southeast Asia. Inside are depictions of dragon,s which show the Sino influence. For those interested in Taoism, this temple makes a fine outing.
Explore in-depth information, experiences and highlights by navigating to specific regions using the links below on the right.
With Remote Lands you'll travel with people who have made Asia the solitary focus of their own lifelong adventure. As our guest, you'll discover Asia on a journey that is completely, authentically your own, adapted from our own remarkable experiences and adventures over the years.
With Remote Lands you'll travel with people who have made Asia the solitary focus of their own lifelong adventure. As our guest, in the continent that our north American founders Catherine and Jay have adored and explored for decades, you'll discover Asia on a journey that is completely, authentically your own, adapted from our own remarkable experiences and adventures over the years.
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Choose somewhere you'd like to visit, something you're interested in, and when you're planning to travel and we'll suggest sample itineraries to inspire your bespoke journey.
As the world slowly opens to travel again, exciting new accommodations and pristine natural wonders are drawing travelers to Malaysia.Read More
Kota Kinabalu isn't just about the mountain. It's jungle, paradise islands, and luxe resorts on the doorstep of a rapidly transforming city.Read More
For the traveler who likes a little luxury with their adventure, these itineraries from Remote Lands offer a Borneo experience like no other.Read More
From the headhunting history of the Murut and the communal Rungus farms to the sea gypsy ways of the Bajau, Malaysian Borneo is awash in tribal cultures.Read More
It's a little bit Penang, a little bit Cameron Highlands, and a little bit something new. Ipoh is a transitional destination on peninsular Malaysia worth a visit.Read More
Cheong Fatt Tze's Blue Mansion in Penang – recently garnering fame for its role in Crazy Rich Asians – is a blend of cultures, an architectural curiosity, and a luxury hotel in the heart of George Town.Read More
Here is a small selection of the kind words our guests have said about us, as well as features by journalists and travel writers.
From the moment I happened upon the REMOTE LANDS website over a year ago, browsed the options, I knew that this would be well worth it. The entire staff is nothing less than professional with service that made us feel like royals.
This was truly the trip of a lifetime. Magical destinations, the most luxurious hotels in the world, and the most wonderful travel companions we could've wished for. We were treated like family everywhere we went and we have 14 new best friends.
We have used some of the top rated travel specialists all over the world and, without question, Catherine Heald and Remote Lands are at the very top of the list!
You are invited to Remote Lands' signature Aman Jet Expeditions, in partnership with our friends at Aman. These are small group journeys designed for people who usually travel independently.
Italy - Morocco - Dominican Republic - Turks and Caicos - USA
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China - Bhutan - India - Sri Lanka
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April 17 - May 3, 2022Read More


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The Clovis culture was thought to be the first humans in the Americas; however, new tools found in a cave in Mexico may say otherwise. Read here to learn more!
A church, mosque, museum... and now back to a mosque. The iconic Hagia Sophia has changed its identity under different rulers. Let's find out more!
Did you know that Mount Rushmore was built on stolen land that belonged to the Sioux Nation? Read more about its history here.
With glaciers retreating from mountain tops, archeologists are finding unexpected treasures such as an old Viking trading route and artifacts! Let's find out more...
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text: May 07, 2003 Moxa Technologies Inc News Facebook LinkedIn Twitter Recover your Redundant Ethernet Ring in a flash300 ms For industrial automation applications, redundancy is always an important issue to help increase the reliability of your system. The recovery time of traditional Spanning Tree Protocol (ex. 802.1D) is too slow to meet the requirement of real-time control and high-speed data acquisition. MOXA EtherDevice Redundant SwitchED6008comes equipped with a network redundant protocolTurbo Ringdeveloped by Moxa, that can help build up your redundant Ethernet network easily. With its ultra high-speed recovery time, once any segment of your network is disconnected, your automation system will be back to normal in only 300 ms. You can use ED6008s built-in Turbo Ring technology to establish an Ethernet backup ring topology. One network segment is blocked logically, and if another segment gets disconnected, ED6008 will automatically use the backup segment to reestablish connectivity. And with a recovery time of less than 300 ms, you increase uptime, and keep your HMI/SCADA system running continuously. Unlike other Ethernet standards (802.1D or 802.1W, for example), you dont have to learn how to configure complex parameters. Its very easy to build up a Turbo Ring redundant ring in 3 simple steps by connecting each switchs port 8 to another EDSs port 7 to form a ring. In a typical Industrial Ethernet installation, 120 nodes would be considered an adequate deployment. Based on these critical test results, we are confident that Turbo Ring can provide a very fast and reliable redundant solution for critical automation applications. In addition, the Ring Coupling function of Turbo Ring can help you separate those distributed devices into different smaller redundant rings, but in such a way that they can still communicate with each other. Different automation applications require different levels of redundancy. Turbo Ring provides media redundancy, and only Turbo Rings fast 300 ms recovery time is sufficient for every critical automation system (compared with Spanning Tree Protocol). As far as device redundancy is concerned, you can also build dual Turbo Rings that in effect provide both device and media redundancy, and with a recovery time that is still a fast 300 ms. Compare this with a typical star topology. Star topologies generally use software logic to switch to from the primary network to the backup network, and as such have a longer recovery time. For detailed product information, visit our website at http://www.moxanet.com. Did you enjoy this great article? Check out our free e-newsletters to read more great articles.. Subscribe


text:
Darleys Perez defeats Jonathan Maicelo
By Jim Dower: In a closely contested match, interim World Boxing Association (WBA) lightweight champ Darleys Perez (32-1, 20 KOs) was able to beat the hard hitting Jonathan Maicelo (21-1, 12 KOs) by a 12 round unanimous decision last Friday night on ESPN2 from the Chumash Casino in Santa Ynez, California. The final judges' scores were 118-109, 118-109 and 120-107.
The fight was much closer than the lopsided scores the judges handed down, as Perez did precious little in many of the rounds and Maicelo was constantly landing the harder shots. In the 11th, knocked Maicelo down with a left hand after hurting him moments earlier.
Many of the rounds were extremely difficult to pick a winner because both guys were fighting so strategically and not letting their hands go enough to establish a clear winner. It was mostly dull action without a lot of punches thrown.
In other action, welterweight Francisco Santana (22-3-1, 1 Kos) destroyed Kendal Mena (20-1, 11 Kos) by a 1st round knockout. The fight was obviously seen as a competitive one on paper beforehand, but Mena was clearly not ready for a fighter in the class of Santana due to the poor opposition that Mena had built his inflated resume on going into the fight. Santana was able to nail Mena repeatedly with clean left hands to the head in the 1st. Finally, Santana loaded up with a huge left hook to the head that put Mena down flat on his back on the canvas. Mena stared at the lights while on his back and was very hurt from the knockout. The fight was immediately halted at that point at 1:43 of the round.
In heavyweight action, a plump 281 pound Jerrell Miller (11-0-1, 9 KOs) waddled his way to an unimpressive six round unanimous decision over 35-year-old Aaron Kinch (5-4-2, 1 KOs). The final judges' scores were 60-54, 60-43 and 60-53. Miller threw a lot of punches, but he lacked power. He appeared to be at least 30 pounds overweight for the fight. The weight is going to need to come off if he wants to find out what he really has as a fighter.
More Boxing News:
- The Trio Vying For British Glory: Chad Sugden on Facing Shakan Pitters and Craig Richards
- Boxing Results: Ted Cheeseman defeats Sam Eggington
- Boxing Results: Srisaket Sor Rungvisai defeats Amnat Ruenroeng
- WATCH LIVE: Srisaket Sor Rungvisai vs. Amnat Ruenroeng
- Sam Eggington: 'I think it's a fight I definitely win and I think I win before the twelfth bell'
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- Eddie Hearn hoping to reach deal on Ryan Garcia vs. Luke Campbell this week
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|Model: Apple iPhone 6s Plus
|processor: Apple A9
|Internal storage: 16GB
|Rear camera: 12-megapixel
|Front camera: 5-megapixel
|Screen size: 5.50
|Resolution: 1080x1920 pixels
|dimensions: 158.20 x 77.90 x 7.30


text:
Why cancer screening is a difficult decision for parents
Pre-implantation genetic diagnosis (PGD) is not something that parents embark on lightly or for trivial reasons. For each potentially risky and emotionally draining procedure undertaken, there is only a one-in-four chance that an unaffected baby will be born. Put more starkly, three out of four attempts will end in failure.
In addition to all the risks for mother and child faced by those having IVF (which is essential to this procedure), from hyperstimulation of the ovaries to multiple birth, there are cruel twists of fate unique to PGD.
For instance, none of the embryos obtained in a cycle may be unaffected, or the only one that is may fail to implant properly, with the pregnancy ending in a miscarriage. Only in families devastated by their