text:
Researchers at the Rudolf Virchow Center of the University of Würzburg have unveiled the molecular effectiveness of artemisinins. These new findings have the potential to advance the development of medicines for diseases such as Alzheimer's, schizophrenia and epilepsy. The study was published in the journal Neuron.
Artemisinin is derived from the leaves and flowers of the annual mugwort (Artemisia annua) and has been used in traditional Chinese medicine for centuries. The effectiveness was investigated by the Chinese researcher Tu Youyou and rewarded with the Nobel Prize.
Schematic representation of the formation of gephyrin-artemisinin complex.
Image: Dr. Vikram Kasaragod, Rudolf Virchow Center
Artemisinin and its semi-synthetic derivatives - collectively known as artemisinins - are used to treat the tropical infectious disease malaria. In addition, these molecules also influence multiple cellular processes in humans.
For example, artemisinins are able to activate the immune system against several types of cancer or to regulate the differentiation of pancreatic T-alpha cells, which could potentially be useful in the therapy of diabetes.
Molecular Mechanisms so far unknown
"Although this clinically-approved drug class is well established and has been used in some extent for centuries, it was unclear which molecular mechanisms underlie the corresponding cellular activities, such as target protein rfhumecognition and modulation," explains Dr. Vikram Kasaragod.
The postdoctoral fellow in the research group of Prof. Hermann Schindelin at the Rudolf Virchow Center is the first author of this article in the renowned journal "Neuron" and ensures with this research work a significant gain in knowledge (see also the related Preview by Ryan Hibbs in the same Issue of "Neuron").
Comprehensive model for the regulation of inhibitory neurotransmission developed
The structural biologist was the first to solve the crystal structures of two different artemisinin derivatives - artesunate and artemether - in a complex with gephyrin. By binding to inhibitory glycine and GABAA receptors, gephyrin acts as a central scaffold protein of inhibitory postsynapses in the mammalian central nervous system. Gephyrin has only recently been identified as an artemisinin target protein.
The results clearly demonstrate how artemisinins target the universal receptor binding pocket in gephyrin and compete with the inhibitory neurotransmitter receptors for an overlapping binding site (see picture). These new findings could thus also serve as an effective tool to understand the physiology of the human brain.
According to Kasaragod, the crystal structures form, together with biochemical, electrophysiological and in vivo data, a comprehensive model of the regulation of inhibitory neurotransmission by artemisinine. According to him, this model clearly describes the interactions between proteins and drugs.
Important step for the development of drugs
"Our data not only provide a solid foundation for understanding how artemisinins are recognized by a target molecule, but will also help researchers to develop and optimize these agents into highly specific modulators of gephyrin. These modulators may play an important role in the treatment of neurological diseases such as Alzheimer's disease, schizophrenia and epilepsy," says Schindelin, the lead investigator.
The data published in Neuron are the result of an interdisciplinary collaboration with other groups at the University of Würzburg, the University Medical Center in Hamburg and the University of Copenhagen.
Dr. Vikram Kasaragod postdoctoral fellow in the research group of Prof. Hermann Schindelin at the Rudolf Virchow Center of the University of Würzburg.
Prof. Dr. Hermann Schindelin is Professor of Structural Biology and Biochemistry. Since 2006 he is head of a research group at the Rudolf Virchow Center for Experimental Biomedicine of the University of Würzburg.
Dr. Vikram Kasaragod (Schindelin Group, Rudolf Virchow Center) firstname.lastname@example.com
Prof. Dr. Hermann Schindelin (Rudolf Virchow Center)
Tel. 0931 31 80382, firstname.lastname@example.com
Dr. Daniela Diefenbacher (Press Office, Rudolf Virchow Center)
Tel. 0931 3188631, firstname.lastname@example.com
Vikram Babu Kasaragod, Torben Johann Hausrat, Natascha Schaefer, Maximilian Kuhn, Nikolaj Riis Christensen, Ingrid Tessmer, Hans Michael Maric, Kenneth Lindegaard Madsen, Christoph Sotriffer, Carmen Villmann, Matthias Kneussel and Hermann Schindelin: Elucidating the Molecular Basis for Inhibitory Neurotransmission Regulation by Artemisinins. Neuron (2019) https://doi.org/10.1016/j.neurin.2019.01.001
Dr. Daniela Diefenbacher | idw - Informationsdienst Wissenschaft
Further reports about: > Artemisinin > Biomedizin > Neuron > anti-malaria > anti-malaria drug > central nervous system > crystal structures > human brain > immune system > types of cancer
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An international research team has found a new approach that may be able to reduce bone loss in osteoporosis and maintain bone health.
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An international research team with Prof. Cornelia Denz from the Institute of Applied Physics at the University of Münster develop for the first time light fields using caustics that do not change during propagation. With the new method, the physicists cleverly exploit light structures that can be seen in rainbows or when light is transmitted through drinking glasses.
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Clifford the Big Red Dog You're Invited! Game
Special Price $10.99 Regular Price $21.99
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Ships In 2-3 weeks, not including transit time.
Join Clifford and his friends Cleo, T-Bone, Mac and Mimi as they race around the board. Drop the die down the dog house dice slide, and see how far you can go! The first player to pass out all of their invitations to friends and make it back to the party wins!
- Includes: 4 Clifford pawns, Clifford dog house dice slide, 16 invitation cards, die, board game and rules
- Ages: 3+
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Unisciti a noi puoi godere :
Nuovo cliente? Comincia qui.Account Personale Miei Ordini Lista dei desideri Miei coupons I miei punti I miei reindirizzamenti BGpay
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A Rising Phoenix
Whether we remain the ash or become the Phoenix is up to us.
~ Ming-Dao Deng
- Build a cathedral rather than cutting stone; help your employees know what your purpose is as an organization.
- Always remember, Entrepreneurs are endurance athletes.
- Embrace facts not opinions.
- Be a constant for your employees, especially during times of uncertainty.
- Customers have changed, learn to remove client objections.
The Full Scoop
This past week I had the pleasure of spending time with a large group of entrepreneurs and business leaders; virtually of course. COVID-19 continues to create changes to our lives in ways we could have never imagined. Business owners the world over have been working overtime to re-engineer their organizations to align with this new reality. It was refreshing to spend time with like-minded individuals, while our organizations may differ; our desire to grow and thrive was a unifying factor throughout the discussion.
As a firm that specializes in IT Service and Support, our mission at the end of the day is rather simple; we want to help organizations implement technology in a way that supports and propels their teams towards their definition of success. That is going to mean different things to different customers. For some they simply need help with a vendor software upgrade or a remote IT Helpdesk. Other clients may want networking or specialized Cybersecurity support, or it could be help with deploying applications and servers to the cloud.
At times, the workload can be very heavy and if we aren't careful, employees can lose sight of our core values and mission. We were reminded that employees need to understand their role within our organization. Our IT Helpdesk staff are not simply answering phone calls and fixing Microsoft 365 issues, they are helping healthcare professionals meet the medical needs of families in our community. Our clients are in a variety of industries, each one serving a vital function within our society; we are helping these organizations meet the needs of their families, stakeholders and customer base; and it is a privilege.
Business owners and leaders need to remember that we are running a Marathon, we are endurance athletes, and taking time to rejuvenate and recenter is critical; not just for yourself, but for your employees. Healthy employees help contribute to healthy organizations.
On a personal level, employees need to hear from you as a leader. Employees need to know you support them in their roles and that they are a critical part of the organization. Colin Powell has thoughtfully remarked,
"Leadership is about people. It is not about organisations. It is not about plans. It is not about strategies. It is about people motivating people to get the job done. You have to be people-centric".
One business leader we heard from stressed the importance of allowing employees to schedule 1:1 time with you as their manager. You can't treat people as cogs on an ongoing basis, and expect them to become more than just a cog. If you want a dynamic and contributing workforce, you need to treat them in a way that encourages their growth and dynamism. Find ways to encourage input from your team, on our IT Helpdesk (for example) there is no one else who works so closely with the business users. We as an executive team need to learn what they know, and find ways to solve the IT problems that clients are experiencing on a re-occurring and evolving basis; this can't happen without good communication.
In technology, we learn quickly that you can't rely on guesswork to fix a network or server issue; there is a right way and a wrong way. Opinions and instability will not help your IT system run properly. Similarly, during this pandemic we need to find ways to focus on facts and best known remedies for navigating through these challenging times. Embracing opinions and rumors within your organization, will just lead to further anxiety and confusion. Let your employees and customers know of your confidence for the future.
As COVID-19 changes our lives, we need to understand that our customers are changing. The needs that they had as an organization last year, are not going to be their same needs this year. Identify the objections that clients have to your product offerings. In our line of work, long contract terms have always been a hurdle to on-boarding clients. We have found that reducing contract terms is a simple way to remove client objections and blockers. Find the blockers that are preventing your team from selling in this new environment, to meet the needs of your clients in today's market.
There is an end to all of this, learn when to play defense and when to play offense. There are organizations that will exit this experience leaner and meaner, and others that will collapse under the rising tide. Use this time to re-center, focus, and push ahead with confidence. As you do, you will reap the many benefits that only come through the refining fire of change.


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Drawing of a swastika on the Snoldelev Stone. Deepti Naval born 3 February is an Indian actress mostly active in Hindi cinema, as well as a director, writer. Member feedback about Fear Factor: He wears only kurta and dhoti , eats his meals on the ground and lives on his pension. Member feedback about Punya Hinduism: Siddharth Arora born 13 April is an Indian television actor.
For his contributions to film, the Government of India honored him with the Padma Bhushan in , and the Dadasaheb Phalke Award in Hinduism is an older religion, while Sikhism was founded in the 15th-century by Guru Nanak. He died at the age of 79 due to liver cirrhosis. Hatha yoga topic "Kapala Asana" yoga headstand or Sirsasana, on a tiger skin , from manuscript of Jogapradipika, Hatha yoga is a branch of yoga, one of the six schools of Hinduism. Her father is a well-known theatre actor, Tushar Trivedi who has been involved in Gujarati plays for over 20 years. Member feedback about Vairengte:
Even at this age, they both share a very romantic relationship. Esha Kansara topic Esha Kansara born August 20, is an Indian model, dancer, television and film actress. Lists of songs recorded by Indian singers Revolvy Brain revolvybrain misscellenous faridul alam faridulalam.
Mukti Bandhan 5th May Episode Part 1 ~
Hinduism Yama is revered in Tibet as the Lord of Death and as a guardian of spiritual practice. Ray has often been critically acclaimed as one of the best Oriya actresses so far.
He also featured in a number of English-language films produced by Merchant-Ivory. Career After completed his graduation he started composing jingle music for various brands including: Newer Post Older Post Home. Member feedback about Shashi Kapoor, roles and awards: Khariar also called Khadial or Kharhial is a City and a notified area committee in Nuapada district of the Indian state of Odisha. The show ended on 29 September Member feedback about List of Kasautii Zindagii Kay cast: Member feedback about Hinduism and Sikhism: Uttaran to Written Updates – She loves her husband and feels lucky to have such a warm family.
In spite of being a father of a multi-millionaire, he still leads a very simple life. She graduated in science from Jai Hind College, Mumbai.
Mukti Bandhan – Episode – 51 to 70 – to | Top Movies Serials
Today's Deals at Amazon Today's Deals. List of characters and cast that worked in the show Kasautii Zindagii Kay. She has a son Gaurav and always wants siddharth to be happy.
He believes that his son is a big man, not him.
Swastika topic A swastika is a symbol found in many cultures, with different meanings, drawn in different styles. Siddharth Arora born 13 April is an Indian television actor.
Member feedback about Anju Mahendru: Member feedback about Indian Television Academy Awards: Chandraprabha is the birth mother of Devki Virani, and had died, before Devki could see her face.
The same year she was appointed to represent India at Queen of the Pacific pageant held in Australia where she was crowned 1st runner-up.
Mukti Bandhan
She has won awards for her performances in many movies. Sanjib Sarkar topic Sanjib Sarkar Epissode Shaivism topic Shiva above is the primary deity of Shaivism.
The manuscripts are found in various ancient literature. Two years later, she played a lead role in Ek Baar Phir. Stubborn and arrogant he always follows his dad and also a big human being. She threatens to overtake him with her business acumen and grounded nature. Anonymous September 9, at 6: Anju Mahendru born 11 January is an Indian actress. Bandhhan life and education Azam was born 25 September in Bangalor


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|"Michael Meng (JIRA)" <j...@codehaus.org>
|[jira] Created: (MDEPLOY-83) Can it deploy to multiple location ?
|Wed, 17 Sep 2008 14:01:49 GMT
Can it deploy to multiple location ? ------------------------------------ Key: MDEPLOY-83 URL: http://jira.codehaus.org/browse/MDEPLOY-83 Project: Maven 2.x Deploy Plugin Issue Type: Improvement Affects Versions: 2.4 Environment: unix Reporter: Michael Meng I need to deploy to multiple locations, I try 1. add another set of <repository>, which define aother location (<urol> and <id>), but seems not working 2. use altDeploymentRepository, but it only deploy it here, not the <repository> on <distributionManagement> any more Is there a way to deploy to multiple location/repository ? Thanks -- This message is automatically generated by JIRA. - If you think it was sent incorrectly contact one of the administrators: http://jira.codehaus.org/secure/Administrators.jspa - For more information on JIRA, see: http://www.atlassian.com/software/jira
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This may be hard to believe, but Theo James is turning 35 years old on Monday, December 16! The actor was 30 when he was introduced to the world as the fan favorite character Four in the movie Divergent, which means it's been five years since the dystopian film series first premiered.
For those who forgot, the film — based on the book series of the same name by Veronica Roth — follows a teen girl who leaves her family behind to join another one of the five factions in a post-apocalyptic society. Other than Theo, the series also starred Shailene Woodley, Jai Courtney, Miles Teller, Tony Goldwyn, Maggie Q and Ansel Elgort.
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Dr. Magdalena BiggarThyroid Surgeon
I grew up in Auckland and attended Auckland Medical School. Thereafter I undertook surgical training in General Surgery in New Zealand, becoming a Fellow of the Royal Australasian College of Surgeons (FRACS) in 2009. Subsequently I gained further specialty training and experience in Breast, Endocrine and General Surgery by working abroad in Australia (Princess Alexandra Hospital) and the United Kingdom (Royal Victoria Infirmary) under the tutelage of surgeons prominent on the world stage in their fields.
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Accredited at the Following Hospitals
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Ascot Hspital
Consultant Surgeon, Counties Manukau Healthboard
Special Interests
Thyroid surgery
Parathyroid surgery (including minimally invasive parathyroid surgery)
Other concurrent specialty interest - breast disease
Breast Surgeons of Australia and New Zealand Member
BreastScreen Aotearoa Accredited
Fellow of Royal Australasian College of Surgeons (RACS)
Academy of Surgical Eductors Member
International Association of Endocrine Surgeons Member
International Soceity of Surgery Member
Member of Endocrine section of RACS
Practice Locations
Auckland Colorectal Centre
17 Gilgit Rd
(behind Mercy Hospital)
Ormiston Hospital
Ormiston Surgeons
Ground Floor - Ormiston Hospital
125 Ormiston Rd
Botany Junction
Manukau Superclinic
Middlemore Hospital and Manukau Super Clinic & Surgical Centre
Counties Manukau District Health Board
Hospital Road, Otahuhu, Auckland, NZ
Contact Details
(09) 623 7410
(09) 623 7411
[javascript protected email address]


text:
Collection 2 - Project Semicolon
For Collection 002, we partnered with project semicolon and were able to raise $214.30 for the fight against self harm and suicides nation-wide.
Collection 001 - TWLOHA
For Collection 001, we partnered with the TWLOHA mental health organization and were able to raise over $300 for mental health awareness and support! With this money, TWLOHA will be able to fund:
6 first time counseling appointments
Live events and blog posts to negate the stigma against mental health
Make it possible for 1800 more people to access their FIND HELP TOOL in order to access support to fight mental illnesses.
Fund their blog, podcasts, and social media, spreading the message of hope 24 hours a day.


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Wide horizon,(The above photo was taken again from all the copyright infringement cases that cannot be printed without the author's product's permission.) [Note: This article was written exclusively by the author!To effectively prevent body fat,Facebook has lived to $ 14.98 billion;With a startling 20 minutes start to reach his flight to the next level,Located in the northwest of Hebei Province,And spend time on children 's needs,The more embarrassing!
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Enjoy Utmost Convenience With Sleek And Retractable Banner Stands
When people have something they want to advertise or let the public know about, they often use banners. These are a great way to catch the attention of others, especially when they are well designed and in a location where they are easy to see. Of course, when you are looking to put up a banner, there will be several things you want to consider so you can ensure you will get the best results from it. One of the factors that is extremely important is the question of what type of banner stand you will use. Retractable banner stands have a lot to offer and they also come in a few different kinds, which will make it easier for you to choose the one that will suit your purposes the best.
Standard Retractable Banner Stands
If you have a banner that is anywhere between 24″ x 81″ and 57″ x 81″ in size, then you can probably find a standard retractable stand to go with it. Standard retractable banner stands are very professional looking and should go nicely with whatever your banner looks like, while being suitable to be used in practically every location. They can come in a few different finish colors, including silver and black. They are also extremely lightweight and portable. When you need to move your banner, all you have to do is retract the stand into its aluminum casing and place it into its carrying case.
SD Retractable Banner Stands
These are suitable for banners that measure from 24″x92″ to 60″x92″. These are more subtle in design, allowing your banner to truly be the center of attention. The components are sleek and elegant in design, yet they are more hidden and less noticeable. This type of banner stand features adjustable side poles so you can ensure it is the perfect height for your banner.
Deluxe Retractable Banner Stands
Perfect for banners that are 33″x81″, these are much like the standard retractable stands. However, the base is sleeker, more polished and of a different design. It is a great way to showcase your banner in a professional and elegant way, but it is still very convenient, retracting easily and fitting into its own carrying case. You can even get one for your double-sided banner.
Choosing the right banner stand does not need to be difficult or confusing.


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|File Name:
|File Size:
4.72 (41)
|Supported systems:
|Windows 10, 8.1, 8, 7, 2008, Vista, 2003, XP, Other
|Free* (*Free Registration Required)
FREE CANOSCAN N670U DRIVER (free_canoscan_3172.zip)
Canon CanoScan N670U is a new or. We use of the best possible experience in consoles. Last day I perchased my solution to 2001. Case, you only need to launch the installation file, while the second scenario allows you to unpack it and follow the instruction. Last day I don t know who viewed. It's best to download the latest version of ScanGear or CanoScan Toolbox / MP Navigator to ensure compatibility between the scanner driver and software.
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About ronnieglasgow66
ronnieglasgow66 is divorced and is seeking females for friendship or a casual relationship or a serious relationship.
You need to have a good sense of humour and not to have the ability to bore me into a catatonic coma, that be a good start. Oh and I don't much like one word answers or indeed long answers that tell me absolutely nothing. You don't have to be beautiful, hilarious, amazingly interesting or brain of Britain material but an ability to have a conversation would be a good start. Then as they say we will take it from there and see what happens, that old cliche but it's true.I still want a love life, preferably being in love while I am having it or at least fancying the person and getting on with them and liking them.
- Hair Auburn / Red
- Eyes Blue
- Height 6' 0" / 183cm
- Weight 14 st 0 lbs / 89kg
- Body type Athletic
- Glasses Sometimes
- Ethnicity White
- DisabledNo
- Stance Left of Centre
GCSEs / O levelsand A levels (or equivalent) and a qualification which was not listed as an option
- Situation Unemployed
- Income I'd rather not say
- Alcohol Light Drinker
- Smoking Non-smoker
- Diet No Special Diet
- Religion Atheist, but I don't practice my religion
- Interests
animals and books and computers and cooking and gaming and health and movies and
music—listeningand music—makingand restaurants and sport—watchingand TV
- Have No
- Want I may want to have children
- Home I rent my home
- Live With Alone


text:
Items where Person is "Padgett-L"
Group by: Date | Item Type | First Author | No Grouping
Jump to: 1984
Number of items: 1.
Finger, M. and Prince, T. A. and Padgett, L. et al. (1984) Energy Resolution Enhancement of Mercuric Iodide Detectors. IEEE Transactions on Nuclear Science, 31 (1). pp. 348-352. ISSN 0018-9499. https://resolver.caltech.edu/CaltechAUTHORS:20140429-083600899


text:
Labour's rural problem
Summer 2020
Labour's identity is deeply tied to ideas about industry and the urban, but the party must now reconsider its engagement with rural issues. One first step in setting out a social democratic vision for the rural future is an evaluation of recent Labour policy.
PDF of article:
Subscribers to Renewal can access this article for free. If you are already a subscriber please login to your account to read the article.
Please note that due to EU VAT charges on digital products, the final price may be slightly different depending on the EU country in which your billing address is located.


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We have been exported to more than 150 countries and well recognized as money-maker for mining and mineral industries.
Note: If you're interested in the product, please submit your requirements and contacts and then we will contact you in two days. We promise that all your informations won't be leaked to anyone.
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Bauxite ore is a kind of mineral which is often collectively formed by gibbsite, a boehmite or a diasporeone.Bauxite can be widely used in many industries, among which the most important is to be used to refining aluminum, working as refractory and abrasive materials, and raw materials for high alumina cement.Raw bauxite crushing process.Read More
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