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Parking App Pays People To Take Photos Of Illegal Parking
The British parking firm called UK Car Park Management, which is responsible for car parks of NHS, Tesco and McDonalds, rolled out an app that gives out money to people who can help report illegal parking problems. The parking app is meant for small businesses who may have a hard time in patrolling their own car parks. Professional wardens and Automatic Number Plate Recognition machines were previously the only things used by Car Park Management to determine the offenders.
Users must download the "i-Ticket" app and make an account. After a successful installation on a mobile device, the user can upload a photo of the car that was illegally parked. The app will direct users to their parking spaces and check out the area for illegal parking. The car park company will offer the uploader with £10, which is around $13 through the mobile app.
The owner of the snapped vehicle will then get an unfortunate fine of £60 or $75. What's worse is that the fine turns into £100 or $125 when it remains unpaid within two weeks. Offenders will not be able to get their revenge easily on the people who reported them as the service promises to be completely confidential.
"The photo uploaded to the app is just the evidence and every one is looked at by a member of staff before a ticket is printed," says the CPM boss, James Randall.
Once in a while, there is going to be an app that will gain considerable user attraction. There was a Chinese beautifying app called "Meitu", which users enjoyed while turning any person into a cute anime-like character. There was, of course, Pokemon Go, which had people going to streets just to snatch a virtual pokemon. For now, it's unclear whether the parking app, which turn can people into paid and active eye witnesses will be a hit.
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Thank you for using LocalsYoga! We love feedback. Please send suggestions to firstname.lastname@example.com
- This yoga event has passed.
Laughter Yoga Club at Dance Warrior in W. Orange, NJ
August 2 @ 4:00 pm - 5:00 pm
Visit www.laughteryoganj.com for more information. Class begins always at 4pm, we meet at 3:45 to check in and get to know one another. We have a brand new home in West Orange after more than a year in Montclair, we needed a bigger space.
In laughter yoga we combine laughter exercises with youthful playfulness and movement, eye contact and deep breathing to connect, unwind, and let go. We laugh for no reason, no sense of humor required, we fake it until we make it! The benefits lasts for days after a laughter session.
The sessions are 55 minutes and are suitable for all ages and abilities. Participants are encouraged to wear loose clothing and bring water, as laughter is like internal jogging. No Yoga mats necessary.
Benefits of Laughter.
Reduces stress and increases joyfulness
Increased Oxygen and blood flow
Lowers blood pressure
Boosts Self-confidence and focus
Strengthens connections with others
Releases Endorphins and reduces pain
Improves energy & mood & outlook
Melts away negative feelings
Provides a light cardiovascular exercise
Did you know…you don't need to be in a good mood to Laugh? In our class we don't laugh because we are happy, we are Happy because we Laugh! See www.laughteryoga.org for detailed information and research about the benefits of a regular laughter yoga practice!
Joan Castellano is a Certified Laughter Yoga Teacher, by Laughter Yoga International Universtiy and she helps people to bring more laughter into their lives. She offers a 2 day Laughter Yoga training several times a year in West Orange. She is CPR certified, insured and has a Master's in Higher Education Administration from Columbia University, Teachers College. She is available for hire to bring laughter wellness into your office, college, senior home, community event and even private parties.
Joan facilitates on-going laughter yoga workshops in the community and at many special events. Contact her for more information on bringing this program to your business, family, college, private parties or senior homes. Visit www.laughteryoganj.com for more details
Our new sponsor in West Orange is Dance Warrior! We are so excited to call this our "Laughter Home" Thank you to Sandra for your generousity!

subset: commoncrawl


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Cape Town - The Ingula pumped storage scheme, which has allegedly seen costs balloon from R8.9bn to R36bn, has pumped billions into South Africa's limping economy.
Eskom said in a statement on Wednesday that Ingula has spent R6bn towards small businesses involving black women and youth and R20m towards the upgrading of schools.
Ingula, situated between Ladysmith and Harrismith in the Little Drakensberg, is a peaking hydro power station, meaning it can supply electricity during times of peak demand. It consists of an upper and a lower dam or reservoir and a powerhouse located 116 storeys underground in two excavated underground caverns.


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What we're about
We are a group of recreational runners that get together for social runs around Dublin. We are not a professional running group. Any run that you participate in you do so at your own risk. It is up to the individual to assess their ability to participate in the run. We advise that participants dress suitably; wear proper running shoes and gear, and in poor light we recommend the use of High Viz Clothing. We take no responsibility for personal injuries or new or existing medical conditions that may be aggravated by running. If you are new to running or exercise in general we recommend consulting your physician before joining us. We are not responsible for property lost during runs.
By applying for membership to this group you are accepting responsibility that all group activities that you participate in are at your own risk. This includes all runs and any other activities. If you are not in agreement, please do not proceed with membership.
Benefits of joining Dublin Runners:
Keep fit
Improve your pace
Attempt longer distances
See parts of Dublin you wouldn't normally visit
Share running tips
Make new friends
Stay motivated
Some of us have minimal running experience, others have lots or train with professional running clubs. Some of us have taken up running for the social benefits!
We are NOT a competitive group. We encourage everyone to start off at their own pace. We always meet up afterwards to make sure the last runner/s arrive safely.
There is a €5 once-off joining fee which we use to pay the meetup.com fees and to provide yearly prizes. Payment is usually by paypal but we can make provisions if you do not have a paypal account by contacting one of the organisers.
Follow us on Facebook at https://www.facebook.com/DublinRunningMeetupGroup and on twitter at https://twitter.com/DublinRunners
Upcoming events (5)
Phoenix park Saturday Morning Group Runs. Further restrictions lifted now allows for larger groups to train together. Social distancing will be observed. Choice of two runs; 10K at about 5:00 to 5:30 min per km 10K at about 6.00 min per km Meeting at the car park of the Visitors Centre, (https://goo.gl/maps/qKbZw) RSVP early, try and arrive 10 min before the run. Please cancel if you can't make it. Remember that access to the park for cars is limited to the Parkgate and Castleknock entrances and there is not a huge amount of parking. The Visitors Centre car park is open at at that time it should not be full. If weather allows we will use the trails as the park is quite busy these days. The Phoenix Cafe is open for takeaway so hopefully we will get to chat and have coffee after. Bring something warm for after. Any questions, just ask.
- Shane O' M.
- Kristijan H.
- Kait K.
- 27 attendees
ALERT NEW ROUTE Head south along the coast past Sandycove & Bulloch Harbour, turn at Dalkey & run along Dalkey main street & up Barnhill road to Killiney Towers roundabout. Take the second exit up Avondale road to The Graduate roundabout. Turn right & head back to Glenageary roundabout, turn right and head to Killiney Towers roundabout, first left and back to Dun Laoghaire (down the hill to the coast). "We run 8-10K each week. There are always several running speeds so come along even if you're a beginner. The main highlight of the morning is to relax in the cafe (Missy Moops beside the Peoples Park) where we reward ourselves with coffee, tea and treats! One thing we can guarantee - you will not find a more supportive group and if you come along once, you'll be hooked!
- Clare
- Billy B.
- 2 attendees
One of the nicest routes you will find out there giving you a mix of surfaces and wonderful views along the wicklow way. The whole route is 25K with the option of a shorter route by turning back (Maybe at the 8K point at the top of Djouce) at any time. There is a lot of climbing in it but the joy of mountain running is that you dont have to run all of it. Details of the full route can be found at https://connect.garmin.com/modern/course/38355811 The route can be uploaded to may watches to help with navigation. We dont leave anyone behind so with stop at regular intervals for people to catch up. You will need: Water (At least 500ml) Splashproof jacket Something to eat Ideally trail runners A couple of us are going to do the route twice on the day as part of a UTMB virtual race so welcome to join us. Details of the challenge at https://utmbfortheplanet.world/challenges As always , lifts will be available but please indicate in the group if you need or can offer a lift. Face covering and common sense needed for lifts. Any questions, just ask. Cheers Shane
- Shane O' M.
- John C. (The Real J.
- 12 attendees
Join us for a 8km run at a pace of 5:45-6:00 min/km commencing at 6.30pm. We will limit the group to 15 people while adhering to social distancing guidelines when running by keeping 2 metres apart and not run on top of each other. We'll meet on Chesterfield Avenue across from the zoo entrance. Remember the side entrances to the park are closed to vehicles & there is no parking allowed on Chesterfield Avenue. Give yourself enough time to get there. Any questions let us know, Kelly & Harry
- Harry
- Kelly
- Fiona
- 9 attendees
Past events (6,058)
- Shane O' M.
- Adrian
- Catherine L.
- 19 attendees


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Jassian Road area, Ludhiana
Jassian Road area, Ludhiana Real Estate - Properties for Sale & Rent, Updates, News & Reviews
- Pincode: 141008
- Property Types: Independent Houses, Residential Plots / Lands, Shops
- Nearby Localities: Naveen Nagar, Deep Nagar, Civil Lines, Bhattian, New Prem Nagar
Looking for a property in Jassian Road?
Have a property in Jassian Road?
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Expert Reviews on Jassian Road
fastly developing area in ludhiana
roads are more wide than main haibowal road
nice neighbourhood
full facilities
good administration
- in te main ludhiana town
- besides railway lines which makes it loud
Jassian Road area, Ludhiana is rated 5 out of 10 based on 1 user reviews.Disclaimer: The reviews are opinions of PropertyWala.com members, and not of PropertyWala.com.
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Jassian Road area, Ludhiana News
Friend kidnaps boy in Ludhiana, beats him to death with bricks- Held when he came to collect ransom A 16-year-old boy, Preet Verma, of Navneet Nagar, Jassian Road, was kidnapped last evening by his friend Vijay Kumar (19) of the Jassian Road area and murdered. more
2 youths kidnap, murder teen; caught in Ludhiana police's ransom trap- Police said that Dashrath Verma, a hosiery worker from Navneet Nagar of Jassian road, Ludhiana filed a 'missing' complaint after the diseappearance of his 16-year-old son Preet Verma on Monday. more
Cops arrest 2 drug peddlers, seize 47kg ganja- Khanna police have arrested two drug peddlers and seized 47kg ganja from them on Ludhiana-Delhi highway. The accused were identified as Rinkal Kumar of Sunil Nagar on Jassian Road in Ludhiana and ... more
Covid-19 shows no signs of abatement- Four persons lost their lives and 69 more tested positive for Covid in the district today. The number of positive cases in Ludhiana has reached 1,839 and the death toll has gone to 47. more
Price Trends in Jassian Road area, Ludhiana
Independent Houses for sale in Jassian Road, Ludhiana
Residential Plots / Lands for sale in Jassian Road, Ludhiana
Shops for sale in Jassian Road, Ludhiana
Projects in Jassian Road
Properties for Sale in Jassian Road
Residential Plot / Land for sale in Bhattian, Ludhiana
20 lakhs
- 167.23 SqMeters Residential Plot @ Rs.11960/SqMeter
- ID: P63228932 — Posted: by Ashish
- Land in Bhattian, Ludhiana
- Residential land available for sell.Located in bhattian.Available at an price of 20 lacit is a freehold property. more details
2 Bedroom Independent House for sale in Naveen Nagar, Ludhiana
47 lakhs
- 117.06 SqMeters Independent House @ Rs.40150/SqMeter
- ID: P29384721 — Posted: by Harish
- Ready to move 2BHK House/Villa in jassian road habowal
- 2 bath,unfurnished,ground floor this residential house is built over 1 floors. The construction has been done keeping in view family needs for space & utility. Great deal, please contact immediately. more details
2 Bedroom Independent House for sale in Civil Lines, Ludhiana
28 lakhs
- 50.17 SqMeters Independent House @ Rs.55810/SqMeter
- ID: P72070768 — Posted: by Kawal Joth
- House/Villa in Civil Lines , Ludhiana
- Interested to sell independent house/villa.Placed at civil lines.Nice semifurnished enhancing decorit has spacious 2 bedrooms and 2 bathrooms. .Want to sell it for rs 2800000.It is a 10 years old property construction. Ground floor has a dining room. It has 2 store rooms and a lobby. ... more details
Rental Properties in Jassian Road
1 Bedroom Apartment / Flat for rent in Civil Lines, Ludhiana
- 58.06 SqMeters Apartment @ Rs.138/SqMeter
- ID: P66248108 — Posted: by Jaanu Lucky
- Builder Floor in
- 1 bhk independent, ground floor, fully furnished with ac, double bed , godrej cupboards, tv, fridge, sofa set, wooden cabinets, chairs, invertor, fans, lights, dressing table gas stove, geyser, attach washroom, washing machine, in new prem nagar near pau behind rose garden,ludhiana more details
5 Bedroom Independent House for rent in Deep Nagar, Ludhiana
- 130.06 SqMeters Independent House @ Rs.46/SqMeter
- ID: P10929022 — Posted: by Sandeep Gauba
- Furnished House/Villa in Deep Nagar Society, Ludhiana
- P g for boys with two time pure homly food available sharing and independent room available with all facility like food and water parking electricity and inverter washing iron. more details


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- Polypropylene cord, recycled paper, brass snap
- Hand-crafted item -- color, size and/or motif may vary slightly
- Snap clasp
- 16 grams
- 22 cm L x 2 cm W
This item was created
by Robert Aidoo-Taylor
Robert Aidoo-Taylor
Isha Jain
Alok Jain
Uma Tripathi
Putu Putri
Samuel Costa
With donor support, UNICEF works in the world's toughest places to ensure children are fed, vaccinated, educated and protected. We're for every child, no matter what. And we'll never give up.LEARN MORE


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-Potential move from Phase 1 to Phase 1.5 starting Monday, August 3rd.
That decision has yet to be made but will be later this week. I will get details about the decision, Phase 1.5, and what that means for volleyball as soon as I receive them.
-Paperwork: Outlined below are LINKS to each form that is required in order to participate. Please click on each for more information.
Please have these forms properly filled out for when we are able to return. ATHLETES MUST HAVE THESE FORMS IN ORDER TO PARTICIPATE.
-Conditioning: Please have athletes continue the at home conditioning program that has been linked in the "Volleyball Update/Conditioning" post.
-At Home Ideas: Below is a link to ball control/passing drills that help work on angles from one of the best liberos in the country!
-Like our Facebook Page for updates and other information. All of the Stratford Athletics articles will be linked there as well.
-Another update will be posted Monday, August 3rd.
Any questions or concerns please email me email@example.com.
Coach Tuuk


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Soakaway in London
Browse trusted local Soakaway in London on TrustATrader, all vetted, with photos of completed work, and reviews from previous customers.
Local Soakaway
We have found a selection of the best, most reliable Soakaway in your area. You can click on a trader profile to find out more information, send email/SMS enquiry, or add them to your call back list.
Don't forget! Please mention TrustATrader when you contact any of our trusted traders.
Pay your trader online by card, where you see this symbol. Exclusive to TrustATrader members!
UK Driveways & Fencing Ltd
Blockpaving & Driveways in London, N4 2JS. Covering all of North London and surrounding areas.
UK Driveways & Fencing Ltd are a trusted, professional company with a great reputation to uphold and have over 15 years experience in the...
James and his team did an excellent job with my new driveway and wall. Would highly recommend James to anyone that asks me.
- Tel: 08006 120 767
- Mob: 07505 154 757
Greater London
Pave Right UK Ltd
Blockpaving & Driveways in London, E15 1XH. Covering London, Essex, Kent and all areas in the South East
All too often a propertys exterior is overlooked but the fact is your driveway is the first thing you see when you return home and the first...
Excellent service, giving professional advice that met our needs. Very obliging in working to our specification. Satisfied clients.
- Tel: 08006 965 142
- Mob: 07721 053 355
ALD Construction and Landscaping Ltd
Blockpaving & Driveways in London, N22 6NB. Covering Wood Green and all surrounding areas
ALD Construction and Landscaping Ltd is a well established, reliable and trustworthy company with over 10 years' experience. We are based in Wood...
The work was done to an excellent standard, fantastic workmen can highly recommend them to anyone. Would use them again without hesitation. Very...
- Tel: 07984 440 202
- Mob: 07502 323 352
ED Paving and Landscapes
Blockpaving & Driveways in London, SW16 1EQ. Covering Lambeth, the surrounding areas and all of Surrey.
Welcome to ED Paving and LandscapesED Paving and Landscaping has been established since 2001 and has been going from strength to strength ever...
More than happy with the work completed by ED paving and landscapes. Wouldn't hesitate to recommend them. Extremely happy with our new drive way.
- Tel: 08005 353 984
- Mob: 07391 455 435
All Tree & Garden Care Ltd
Blockpaving & Driveways in Tooting, SW17 0TX. Covering South West London and all surrounding areas
If you are looking for a blockpaving specialist in London, All Tree & Garden Care Ltd can help. We have been transforming driveways for over 10...
All Tree and Garden did an excellent job and I would thoroughly recommend them. Punctual, friendly, clean, managed to find great materials despite...
- Tel: 0208 7677 730
- Mob: 07515 695 202
Don't forget! Please mention TrustATrader when you contact any of our trusted traders.
Pay your trader online by card, where you see this symbol. Exclusive to TrustATrader members!
LR Paving Ltd
Blockpaving & Driveways in London, W3 0PH. Covering all surrounding areas within a fifty mile radius
If you are looking for a blockpaving specialist in London LR Paving Ltd can help.We have been transforming driveways for over fifteen combined...
LRPaving have transformed my new build garden in less than a week and I am over the moon with the results. We had a large Indian Stone patio...
- Tel: 0208 5283 221
- Mob: 07379 074 098
Premier Landscaping
Blockpaving & Driveways in London, E4 8TX. Covering East London, North London and Essex.
If you are looking for a blockpaving specialist in Waltham Forest Premier Paving Services can help. We have been transforming driveways for many...
I highly recommend Tom and his team at Premier Paving; they cleared out an old garden patio and wall and installed a new patio and fence for us....
- Tel: 0208 4857 938
- Mob: 07542 528 375
Platinum Drives & Patios
Blockpaving & Driveways in Lewisham. Covering Lewisham and all surrounding areas.
Platinum Drives & Patios are a trusted, professional company with a great reputation to uphold and have over 20 years experience in the trade.We...
James and his team arrived very promptly on the first day and and had the front drive demolished, cleared, and repaved in a few days. Really quick...
- Tel: 0208 485 7089
- Mob: 07917 184 913
Mike's Paving & Landscaping
Blockpaving & Driveways in London, N13 4BS. Covering North & South London.
Mike's Paving & Landscaping are a trusted, professional company with a great reputation to uphold and have over 20 years experience in the trade....
Mike and his team has been excellent and we loved their professionalism and skills. I already recommended my brother and friend. Mike delivered...
- Tel: 08002 465 721
- Mob: 07490 876 087
The Affordable Driveway & Landscape Company Ltd
Blockpaving & Driveways in Mitcham, CR4 3HH. Covering London, Surrey & Kent including Croydon, Bromley, Wimbledon, Sutton, Streatham, Merton and Tooting.
The Affordable Driveway & Landscape Company Ltd are a trusted, professional company with a great reputation to uphold and over 20 years'...
Would highly recommend Tommy and the team for a garden landscape project. They completely removed our old garden, with old concrete beds and a...
- Tel: 0800 622 6889
- Mob: 07506 736 548
Other services relating to Soakaway in London
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Our average rating for Soakaway
Elite Pave Ltd, Hemel Hempstead
5 out of 5.0
"Driveways for three neighbouring properties. Great job Maany and his team where fast efficient great workmanship and..."
Julie C. on 4th August 2020
Keyline Paving, Redhill
5 out of 5.0
"Did a great job with the driveway and fencing."
Vish Chandra on 4th August 2020
The Affordable Driveway & Landscape Company Ltd, Mitcham
5 out of 5.0
"Would highly recommend Tommy and the team for a garden landscape project. They completely removed our old garden, with..."
Peter Cullen on 4th August 2020
Shields Landscapes, Sidcup
5 out of 5.0
"Martin built a block paved driveway for us around 6 months ago. The quality of Martin's work speaks for itself and we are..."
Callum Sullivan on 4th August 2020
M&S Garden Services Ltd, Letchworth Garden City
5 out of 5.0
"A high standard of work as usual. Mark and his team always do a good job"
Ian Merton on 4th August 2020
Other locations for trusted Soakaway
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Do you work in London? Are you a reliable and trustworthy trader looking to generate more work for your business?Join us today


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Elfin Cove, Alaska (AK) Travel & Leisure Companies
Featured companies
Elfin Cove Sport Fishing Lodge
PO Box 44
Elfin Cove AK 99825
(907) 239-2212
Eagle Charters
Elfin Cove AK 99825
(907) 239-2242
Cross Sound Lodge
Cross Sound Hts
Elfin Cove AK 99825
(907) 239-2210
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Eagle Charters
PO Box 77
Elfin Cove AK 99825
(907) 239-2242
Northern Star Charters
PO Box 24
Elfin Cove AK 99825
(907) 239-2250
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Top Stories
UBS flags buyback possibility after Second-quarter earnings beat
UBS , the world's largest wealth manager, on Tuesday signalled the possibility of resuming share buybacks later this year after generating more income than expected in the first six months and as it boosted...
Tue, Jul 21 2020
Greece calls EU recovery fund deal a 'national success'
Prime Minister Kyriakos Mitsotakis called a European Union deal on a post-pandemic recovery fund a "national success" that would allocate Greece around 72 billion euros ($82.38 billion) to help deal with...
Tue, Jul 21 2020
UBS second-quarter net profit dips as Swiss business dampens trading bonanza
UBS , the world's largest wealth manager, saw net profit drop 11% in the second quarter as higher trading activity failed to offset a pandemic-induced slump in retail and corporate banking.
Tue, Jul 21 2020


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uPASCAGOULA, Miss. (AP) — The air is a little sweeter now that a Mississippi Gulf Coast community is spraying a vanilla scent to mask the odor of its wastewater treatment plant.
More than two dozen machines recently started blowing scented mist into the air 19 hours a day at the Pascagoula-Moss Point wastewater plant.
The owner of a wig and jewelry boutique near the plant, Gerrie Hicks, tells WLOX-TV that she previously noticed a "foul odor" lingering in the air. She says that now it's possible to sit outside or walk around downtown Pascagoula without being bothered by the smell.
The Jackson County Utility Authority director, Tommy Fairfield Jr., says the vanilla scent was selected by a smell team.
uSAME-SEX COUPLE FEATURED ON 'MY LITTLE PONY' FOR FIRST TIME: NEW YORK (AP) — Coinciding with Pride Month, the Discovery Family cartoon series "My Little Pony" has introduced a same-sex couple on the show for the first time.
Writer-producer Michael Vogel told People on Thursday the timing of the episode, "The Last Crusade," is a happy coincidence. The episode introduces a lesbian couple, Aunt Holiday and Auntie Lofty. They care for Scootaloo.
The episode has already aired in Europe and will be broadcast in the United States on Saturday. In May, the animated children's series "Arthur" on PBS showed the gay wedding of Arthur's teacher, Mr. Ratburn.
Co-showrunner Nicole Dubuc told Buzzfeed News the core of "My Little Pony" is to embrace what truly defines a family — love.
uOFFICIALS: 5-YEAR-OLD SHOOTS TODDLER IN HEAD, UNCLE CHARGED: GRAY, Ga. (AP) — Authorities say a 5-year-old shot a 2-year-old sibling at a Georgia home while playing with a gun and now the children's uncle has been charged.
News outlets report the children found the gun in the home Wednesday and were playing with it when it discharged. The Jones County Sheriff's Office says the 2-year-old was shot in the head and is in critical condition.
Authorities charged 18-year-old Darius Johnson with reckless conduct and theft.
Jones County Sheriff's Captain Jimmy Black says the gun was stolen during a burglary about two weeks ago.
Johnson lived at the same home as the children when the shooting occurred. Sheriff Butch Reece says the gun was left where the children could get it.
uUTAH OFFICER WHO PULLED GUN ON BLACK CHILD SPARKS PROTESTS: WOODS CROSS, Utah (AP) — Activists are planning to protest at a police agency in northern Utah after learning an officer who pulled his gun on a 10-year-old child will continue to work.
Black Lives Matter in Utah founder Lex Scott said Thursday they will hold a protest Friday night to demand the officer be fired.
Woods Cross Police Chief Chad Soffe said Monday he is not looking to terminate the unidentified officer.
Jerri Hrubes, who is black, said a white Woods Cross police officer pulled his gun on her son while he was playing outside on June 6.
Soffe said the officer mistook the boy for a potential suspect during a pursuit of armed suspects.
Hrubes said the officer apologized but she still wants the agency held accountable.
uTEXAS CITY BANS ABORTION, SAYS IT'S A 'SANCTUARY' FOR UNBORN: WASKOM, Texas (AP) — A small Texas city has passed a local abortion ban and declared itself a "sanctuary city for the unborn."
Right to Life of East Texas says the vote Tuesday by the all-male Waskom City Council means the city along the Louisiana border is "standing for life."
The ordinance refers to groups that provide abortion services as "criminal organizations."
City leaders expressed concern that Louisiana's new, tighter abortion restrictions could lead women to travel to Texas for the procedure.
The ordinance is largely symbolic, as no one was performing abortions in Waskom or had expressed a desire to do so.
uSCHOOL: VIDEOS OF UNWANTED SEXUAL CONTACT AREN'T HARASSMENT: NASHVILLE, Tenn. (AP) — Lawyers for metro-Nashville's public schools say it's not sexual harassment when students share secretly recorded videos of unwanted sexual encounters and then bully the victims.
The Tennessean is reporting on lawsuits by parents of four girls who say they were pressured into sexual contact and then taunted when students shared the videos.
U.S. District Judge Aleta Trauger denied the district's dismissal request last month, finding "ample evidence" that officials knew of harassment, including the circulation of videos, and failed to protect students. In just four years, the district documented 45 sexual assaults, 218 inappropriate sexual contacts, 950 instances of sexual harassment and 1,200 instances of inappropriate sexual behavior.
uJURY SENTENCES FATHER TO DEATH FOR KILLING HIS 5 CHILDREN: COLUMBIA, S.C. (AP) — A South Carolina father was sentenced to death Thursday for killing his five children with his own hands. After they were dead, he drove around with their bodies for nine days before dumping them in garbage bags on the side of an Alabama dirt road.
Timothy Jones Jr. showed no emotion as the jury delivered the verdict after less than two hours of deliberation. They also could have sentenced him to life without parole.
The same Lexington County jury convicted Jones of five counts of murder last week in the deaths of his children, ages 1 to 8, in their Lexington home in August 2014.
Prosecutors pushed for a death sentence. Solicitor Rick Hubbard said in his closing argument earlier Thursday that if any jurors had doubts whether Jones deserved the death penalty, they should just consider the five garbage bags where he dumped their bodies in rural Alabama.
But a lawyer for Jones told jurors they alone could show mercy — if not for a father who killed five kids with his own hands, then for a family that has seen so much death and still wants to love Jones, even through prison bars.
Jones' father hung his head in his hands as the verdict was read and other family members appeared to cry. Afterward, Jones' family left without speaking to reporters. The defense indicated they would appeal.


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Invert music and retrograde
This may have been addressed before, but I haven't heard of a response yet.
It would be great if the following two features could be put into MuseScore:
Invert a stave or two staves (piano staves) - typically about a centre note - say A.
Thus G4 would go to B4, while D4 would go to E5 etc. It'd be great if this could be done for a whole piece, but even just a couple of lines would be good.
Generate a retrograde version of a piece - all the notes with the same length and pitch values, but taken from the end through to the beginning. Even if all the dynamics and other markings were taken out this would be useful. Again, ideally this would be for a whole piece with no limits on length - or perhaps even on number or staves (instruments).
Even if only partial, this could be a great tool for composers.
In reply to https://musescore.org/en… by Shoichi
Thanks. I'll check that out, and see if it'll do more than one stave or chords etc. That might solve the retrograde issue I was hoping for, though the invert issue remains. There is another way - but it would be good to have it in MuseScore.


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Scarlett Moffatt has addressed her exit from ITV's CelebAbility, after Stacey Solomon took over as team captain.
Speaking to OK! Magazine, the star explained that she simply had other commitments which prevented her from returning for the new series of the Iain Stirling-fronted show.
She also commented that she felt like the media attention surrounding her departure from CelebAbility overshadowed Stacey joining the cast.
"When I didn't carry on with my place on CelebAbility, it was because I was doing panto," she said.
"I've felt that the stories about me are taking the focus away from my friend Stacey, and I don't want that. I've spoken to Iain Stirling and I know Stacey's going to be amazing.
"This is about her, not me, so everyone needs to let her shine.
"I'm over the moon for Stacey. She's perfect for the role."
Related: Stacey Solomon hits back at trolls who criticised her appearance on The Big Fat Quiz of the Decade
Iain also had high praise for Stacey. Speaking recently to The Version, he said: "She is just brilliant. She is an absolute professional, an absolute charmer and a joy to work with. It's been a real honour actually. TV royalty!"
CelebAbility airs on ITV2.
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Want up-to-the-minute entertainment news and features? Just hit 'Like' on our Digital Spy Facebook page and 'Follow' on our @digitalspy Instagram and Twitter accounts.


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Posts Tagged 'Photography'
The Best Camera Bags for Run-and-Gun Videography
Tote around your camera equipment with comfort and security. This video review looks at three of popular sling bags for DSLR photo/video shooters.
4 Ways Still Photography Can Make You a Better Cinematographer
In this article, we examine visualizing light through photography — and how it can make you a better cinematographer and filmmaker.
The Creative Motivation Behind Deep vs. Shallow Depth of Field
This breakdown covers a range of creative motivations behind these two aperture settings, as well as the pros and cons of using each category.
Three Cheap, Underappreciated Cameras Filmmakers Should Consider
Research demonstrates, in a crowded marketplace, sometimes your best options aren't always the biggest, most expensive name brands.
Why Filmmakers and Photographers Prefer to Use Soft Light
In this article, we take a look at why most filmmakers and photographers prefer to light their subjects with large, soft light sources.
7 Tips for Shooting Event Video and Photography at the Same Time
Consider the following advice for recording video and taking photos (at the same time) before shooting your next live event.
Lens Tips: Doing the Work of Four Lenses with Only Two
Primes vs. zooms. Four lenses out of two. Here are a few considerations to keep in mind when shopping for your first lenses.
Set Photographer Matt Kennedy on Shooting for Marvel and More
Still photographer Matt Kennedy shares insights about shooting for both big projects like Black Panther and smaller, more intimate productions.
Video Tutorial: Improving Your Time-lapse Workflow for the GH5
One of the most exciting features on the Panasonic GH5 and GH5s is the ability to shoot RAW, high-resolution time-lapses in-camera.
The Most Exciting Camera Rumors of 2019
Another new year, another new round of juicy camera conjectures. Here's your officially unofficial 2019 camera rumor roundup!
A Guide to In-Camera Multiple-Exposure Photography with the Canon 5D Mark IV
Learn to unlock the potential of your Canon 5D Mark IV with this powerful, in-camera multiple-exposure photography functionality.
Panasonic Unveils Their New Mirrorless L-Mount Cameras
The mirrorless camera wave continues to gain momentum as Panasonic reveals two new L-mount camera models forthcoming in 2019.


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What is it worth?
I have a 1993 Dodge Ramcharger in fair to rough
condition that will not go in reverse. Drives forward
fine. It has a 5.2L V-8. I was just hoping to get
some idea of if it has any value as I want to sell it
for parts or fix.
2 Answers
Google NadaGuides and enter information, i.e. make/model, year, mileage
Google: NadaGuides, enter make/model, year, mileage


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I am a big fan of Homeboy Industries in Los Angeles as I explained in a recent post. This past weekend, the Wall Street Journal detailed a new solar industry-training program started by Homeboy in the past year. I smiled when I read this because I have been brainstorming new job training opportunities over the last few months. One of the concepts that I am exploring is solar energy installation.
We are always looking for opportunities to create businesses that employ individuals rebuilding lives from addiction, homelessness or felony convictions. The perfect opportunity provides a skilled labor-intensive position in a sustainable industry with the possibility of living wages. The burgeoning solar industry seems like it may offer such a mix of opportunity over the next few years in Colorado.
I blogged last year about how the sustainable energy industry is growing in Colorado because of its proximity to the National Renewable Entergy Labs in Golden. The Wired grant provides funds to train individuals with felony convictions for jobs in this industry. In a similar way, solar energy installation is a great job opportunity for individuals with felony backgrounds if we can find a solar training partner. It appears that the new tax credits for solar energy installation finally make such an option cost-effective for the typical homeowner. And even if the industry doesn't prove itself to be sustainable in the long run, it is a useful first step towards training in HVAC and electrical contracting---other fields we have felt would be attractive for the clients we serve. For organizations or individuals interested in building a high-impact faith venture, I think the solar industry deserves further examination.
Exploring the intersection of faith & entrepreneurship for disadvantaged communities.
Thursday, February 19, 2009
Is Solar an Opportunity for Faith Ventures?
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Teen Challenge's BAM Thrift Store Profiled on Fox 13 Memphis
Check out Teen Challenge's BAM Thrift Store in Memphis, Tennessee, profiled recently on the local Fox station. Work is such an importa...
I was excited to see Catherine Rohr's essay "Why You Should Hire Ex-Cons" in Inc today. She makes a wonderful case that I hope...
For a long time there has been a hole in international development and business as mission in the area of sales training.I was excited to be introduced to the Whitten & Roy Partnership recently over lunch by one of its consultants. There are so many gre...
Check out Teen Challenge's BAM Thrift Store in Memphis, Tennessee, profiled recently on the local Fox station. Work is such an importa...


text: A Fan Choice Vote- Just for Fun! Jul 19, 2008 6:52:29 GMT -5 Quote Select PostDeselect PostLink to PostMemberGive GiftBack to Top Post by David Skywalker on Jul 19, 2008 6:52:29 GMT -5 I thought this would be a fun thread to do to dream about Hasbro giving us a fan choice figure in every pack and us voting for them.So I thought we could do a mock Fan Vote to see how it would turn out.THE RULES:You can't vote for Series 5, starter set, battle master, gold figures, or tourniment figures.You vote for 5 commons and 5 Rares.I posted this in the Star Wars board for a reason this is a SW vote.The Uncommon figures from S1-3 are grouped in with the rares.Ok now my vote.Common:1. S2 Jedi Knight2. S4 Wicket3. S1 Wookiee Scout4. S1 Battle Droid5. S3 Rebel TrooperRare1. S1 Yoda2. S4 Darth Vader3. S1 General Grievous4. S2 General Grievous5. S2. Destroyer Droid


text: Esperanza Spalding WRTI's NPR Live Sessions Video of the Week: Pianist Victor Gould Plays "Ascension" By Bobbi I. Booker • Jul 6, 2020 Pianist Victor Gould took a shine to the piano at age four and has been sparkling on the keyboards ever since. Born in Los Angeles, Victor's piano virtuosity has made waves in New York's renowned jazz scene and beyond. We Insist: A Century Of Black Music Against State Violence By Bobby Carter, Nate Chinen, Ann Powers, Shana L. Redmond & Oliver Wang • Jun 30, 2020 In the liner notes to John Coltrane's 1964 album Live At Birdland, Amiri Baraka (then writing as Le Roi Jones) contemplated the gift the saxophonist and his band offered with this music inspired by the horrific deaths of four Black girls in a Birmingham church bombing inspired by white supremacist hatred. "Listen," Baraka wrote. "What we're given is a slow delicate introspective sadness, almost hopelessness, except for Elvin [Jones], rising in the background like something out of nature... a fattening thunder, storm clouds or jungle war clouds. WRTI's NPR Live Sessions Video of the Week: Trumpeter Arnetta Johnson & SUNNY Perform "Who Are You" By Bobbi I. Booker • Jun 29, 2020 Trumpeter Arnetta Johnson discovered the trumpet a dozen years ago as a "band geek" at Creative and Performing Arts High School in Camden, NJ, and went on to study at the Berklee College of Music in Boston. Mentored by both Jill Scott and Tia Fuller, Arnetta blossomed from her first professional gig with the Unity Community Center's (UCC) Little Jazz Giants, to being the featured trumpeter on both Beyoncé Formation and On The Run II tours. All Songs +1: Our Most Memorable Tiny Desk Jazz Sets By Bob Boilen • Nov 3, 2016 Patrick Jarenwattananon has been the backbone of our jazz coverage almost since NPR Music started in 2007. Patrick came to us as a 22-year-old intern and shortly after began covering legendary and rising jazz luminaries like a veteran journalist. His writing for A Blog Supreme captured the spirit of the jazz community and was a rich resource for thoughtful coverage on this living American musical culture. Esperanza Spalding Ticket Giveaway! By Maureen Malloy • Apr 16, 2012 I'll be giving away tickets all week long for the upcoming Esperanza Spalding concert at the Electric Factory! The Grammy award-winning bassist/vocalist/composer will be in town on May 13th. Tune in between 9:30 and 10:30 pm, Monday through Thursday, for your chance to win a pair of passes for the show!


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Know more about this business than we do? Cool! Please submit any corrections or missing details you may have.Help us make it right
Be the first PennLive.com user to add photos or videos of DR Steven Bossinger MD
Dr. Bossinger preformed a kidney stone removal for my son, via a stent being placed. He fully explained the procedure and answered every question we asked of him. He was very professional and had a bedside manor that was exceptional. He took it upon himself to follow up in person after the procedure and again answered questions and set expectations. He also suggested that my son make a few...
Dr bossinger met with me at the hospital shortly after being admitted for severe kidney stone issues.
Took his time examining me, educating me on the procedures that I'd be facing and made me feel comfortable from the very beginning.
Prescribed meds to get me through until my follow up appointment at his private practice, and was a real pleasure to have as my doctor throughout the entire...
Good experience after having a horrible time with another urologist. He was able to explain clearly procedures and future steps to be taken and didn't seem in a hurry to get me out of his office. Would recommend him.
when I checked and the receptionist was rude and acted like she didn't want to talk to me I waited forever in the waiting room to see the doctor and also in the patient room when he finally came in he talked to me and explained everything fairly well suggested getting an ultrasound so I scheduled that for a week later I've been waiting for weeks for him to call me with the results of that tell...
Dr. Bossinger needs to cut the apron strings. His mother is the nurse in the practice. She attempts to diagnose her son's patients before he enters the room. My family physician recommended that I see a urologist, however, his mother told me I didn't need to be there. In addition, she was yelling in the waiting room about another patient being in the restroom when he had a catheter. This...
Dr. Steven Bossinger, MD treats patients in Altoona, Pennsylvania, specializing in pediatric urology.
Dr. Bossinger is licensed to treat patients in Pennsylvania.
In addition to having active medical licenses, Dr. Bossinger has been found to hold one or more active medical licenses, and successfully passed a malpractice history screening.
Altoona Urologic is located at 1701 12th Ave, Altoona, PA. This business specializes in Doctors & Clinics.
Altoona Urologic serves Altoona, PA and is located in the 16601 ZIP code. Altoona Urologic falls under the following categories: physicians & surgeons urology.


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Chamber Events
Come participate in some of our amazing Chamber events! Meet new people and socialize with other local businesses!
Fourth of July Info
Special Fourth of July Parade Salutes Hailey's Heroes The coronavirus pandemic has turned life upside-down here in Hailey and throughout the world. It has made it challenging to do some…Read More
COVID-19 Update: Order to Self Isolate for Blaine County
An Order to Self Isolate for Blaine County was passed by Governor Brad Little on March 20, 2020. It is in effect until at least April 13, 2020. The full…Read More
December BAH at Jane's Holiday House
The Chamber's December Business After Hours at Jane's Holiday House 12 East Bullion Street in Hailey Thursday, December 19th from 4:30-7pm The Chamber would like to invite businesses and…Read More
Turkey Trot Sign up & Information
The 16th Annual Hailey Turkey Trot will take place in Hailey on Thursday, November 28th at 10am. The first 500 folks to register will receive a special Swag Bag. Register…Read More
Halloween Happenings
There's an old saying around here that winter starts the day after Halloween. Unfortunately, it appears that Mother Nature forgot the schedule this year and painted our orange and yellow…Read More
October BAH at Lago Azul
Our October Business After Hours will be at Lago Azul 14 West Croy Street in Hailey Thursday, October 17th from 5-7pm Free and open to the publicRead More


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Advantageous Selection with Intermediaries: A Study of GSE-Securitized Mortgage Loans
52 Pages Posted: 22 May 2020
Date Written: April 12, 2020
This paper studies inefficiencies arising from advantageous selection in the US mortgage market. I estimate an industry model, which exploits the GSE pricing rule on guarantee fees that creates exogenous variation in interest rates. I find that the GSEs' mortgage subsidy leads to a deadweight loss of $8.38 billion relative to a benchmark without a mortgage subsidy. My counterfactual analysis studies how these inefficiencies interact with competition among intermediaries and information asymmetry. Under the mortgage subsidy condition, more competition among lenders (i.e., a 50% decrease in market concentration among lenders) and symmetric information reduce efficiency by $1.42 billion and $3.67 hundred million respectively. On the other hand, without the mortgage subsidy, the same increase in competition among lenders and symmetric information improve efficiency by $3.94 hundred million and $1.77 billion respectively.
Keywords: Advantageous selection, financial intermediates, vertical market structure, pricing, mortgage
JEL Classification: D82, G21, L11, L22
Suggested Citation: Suggested Citation


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SPRING provides $6 million worth of grants to 15 technology start-ups
Scheme provides funding to bridge the gap between an innovative technology idea and the market. -ST
The 15 selected projects cover a wide range of technology areas such as medical devices, electronics, engineering, water and environment and infocomm. SPRING has supported more than 150 projects totalling more than $50 million since the scheme was launched in 2008.
Here is the full statement from SPRING Singapore:
Fifteen start-ups have been awarded Proof-of-Concept (POC) and Proof-of-Value (POV) grants totalling $6 million under SPRING Singapore's Technology Enterprise Commercialisation Scheme (TECS), which aims to bring potentially disruptive technologies closer to the market.
The 15 projects cover a wide spectrum of technology areas including medical devices, electronics, engineering, water and environment, as well as infocomm.
Among the projects supported are three which could make a notable impact on the healthcare sector when commercialised. One of them, Neurostyle, is developing a new way to teach the brain to 'rewire' itself - through virtual reality games - that can help stroke patients recover the movement in their affected limbs. Another start-up, Hexalotus Technology, is coming up with a 3D model that will improve the planning and treatment of liver cancer. Its web-based platform has the added advantage of facilitating consultation and assistance among doctors. T.Ware is developing a therapy system to calm autism patients who can go into uncontrollable fits. Using its T.Jacket which simulates deep pressure massage, a therapist can customise the rhythm and pressure of the 'hug' of the jacket according to the patient's needs. A single therapist can thus attend to many patients at the same time.
Mr James Teh, Founder and Executive Director of T.Ware, said, "While we are still in the early stages of starting up, we believe our idea is very promising and we have a strong team to see the project through. The grant supports our R&D process to build and test the prototype with actual patients, in particular children with autism. When commercialised, the T.Jacket will be the first in the world to give autism patients comforting 'hugs' at the touch of a smart phone. It is convenient for both the wearer and the care giver to use and contributes to the patient's overall well-being."
The TECS grant was also awarded to start-ups which are developing technologies for the water and environmental sectors. For instance, Envichem has found an environmentally-friendly way to recover valuable metals such as nickel and tin from waste metal parts. The recovery is now done using large amounts of hazardous chemicals, which incur high chemical and waste treatment costs. The new technology allows the 'bath' which the metal parts are soaked in to continuously regenerate. This reduces the amount of chemicals needed while not compromising on the efficacy of the process.
Worldwide demand for clean and safe water is driving the development of monitoring systems for water quality. This increasingly lucrative market is what Water Optics Technology hopes to have a share in. Its 'parasitometer', which offers real-time monitoring of water quality, can potentially set a new benchmark by reducing the time needed to detect germs and bacteria from several days to just 24 hours. Dr Liu Ai Qun, founder of Water Optics Technology, said, "We have spent several years developing the technology for our water quality monitoring system. With the grant, we are able to further the research needed towards being a leader in water quality monitoring to improve the lives of people around the world. We are much encouraged by the interest of potential customers like PUB, who has helped validate our technology and build up our credibility. Once our technology is commercialised, we will be targeting the global water monitoring market, which is estimated to be worth more than $7 billion and growing at 8 per cent a year."
Members of SPRING's Evaluation Panel were impressed with the quality of the projects. Dr Sze Tiam Lin, Director at the Intellectual Property Intermediary (IPI) and an evaluation panel member, said, "Some of these projects promise to have a far-reaching impact. For example, Water Optics Technology's water quality monitoring system will provide a much-needed solution to address the increasing demand for real-time rapid detection of waterborne pathogens. It has the potential to set the gold standard for water quality monitoring. With sizeable demand, especially in the developing countries, the start-up will do well to seize the opportunities there."
Another start-up that promises to have a huge impact is Zimplistic, which is developing the world's first fully-automatic flatbread maker. The Rotimatic, which can make a range of soft hot flatbread or roti such as chapati, could well find its way into the homes of the millions who eat flatbread as a staple and now make them by hand - a labour-intensive process which also requires skills. Zimplistic's CEO, Mr Rishi Kumar, is excited about bringing the Rotimatic to these markets. He said, "Key to the project is the development of a sensing system that can adapt to various flour types, which have different water absorption characteristics and capacities. Fine-tuning this technology requires high risks and R&D costs, but the grant has helped us to manage these and improve our chances of success."
Another evaluation panel member, Dr Tan Guan Hong, who is a Programme Director at A*Star's Institute for Infocomm Research, said, "We are impressed with Zimplistic's prototype of the Rotimatic. It demonstrates high commercial value and has the potential to not just meet, but even create a market need. It is likely to appeal to expats of South Asian origins, who will find it a convenient and hassle-free way to make rotis which taste as good as those made by hand."
Ms Chew Mok Lee, Assistant Chief Executive of SPRING, said, "The TECS provides funding during the critical, pre-market stages to bridge the gap between an innovative technology idea and the market. Technology start-ups face particular difficulties in commercialising their products or services due to the risks involved in the R&D of new and potentially market-changing technologies. Hence, SPRING launched the TECS in 2008 to help these start-ups undertake further development to bring their ideas closer to the market."
SPRING has supported more than 150 projects totalling more than $50 million since TECS was launched. Recent start-ups which were supported include Sofshell, Clearbridge Biomedics, and Endomaster, which have gone on to win international awards and ventured into overseas markets with their market-changing technologies.
Start-ups which are interested to apply for SPRING's TECS can submit their applications at www.spring.gov.sg/tecs. POC proposals are accepted throughout the year while invitations for POV proposals are made on a quarterly basis. The current quarterly grant call for TECS POV will close on 30 June 2013.
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Shah: Hello, thank you for joining us today. We are here at the American Society of Hematology's annual meeting in New Orleans in 2013. I have the pleasure being joined today by Professor Giuseppe Saglio from University of Turin in Italy, and we want to touch upon a couple of important issues, one involving monitoring changes in recommendations for monitoring, and then the other being an abstract that Professor Saglio is going be presenting on updated information on one of the randomized studies of a second-generation kinase inhibitors, in this case nilotinib versus imatinib in previously untreated patients. But first as I mentioned, we want to touch upon this issue about monitoring because there have been changes lately. Certainly from the NCCN perspective where previously bone marrow assessments were recommended every 6 months until achievement of a complete cytogenetic response. However, more recently, in response to a wide range of data that has come from numerous sources, largely from European studies, that achievement of PCR level or BCR-ABL level of 10% or lower on the international scale is associated with superior overall survival in patients who are treated with imatinib, and we have now seen that also in patients who are treated with the second-generation agents, either in the second line or in the front line. In light of the fact that it is an early intervention time point, the NCCN Guidelines have been changed to reflect this, that if you start a patient for instance on imatinib and they fail to get to this level of molecular response, it is actually recommended to switch these patients to a second-generation agent because of course studies are showing that at least in the front-line setting, these second-generation agents get a higher proportion of patients to deep cytogenetic and molecular responses. So, as a result of that, a 3-month time point is an important time point. If you do not have access to a good PCR test, then you can perform bone marrow aspiration for cytogenetics and look for the presence of a major cytogenetic response, meaning 35% or fewer Philadelphia chromosome containing metaphases, and again, if patients fail to meet that, they should be switched. It is of course recommended to continue to monitor patients every 3 months and ensure that they are continuing to be stable or declining if they are responding, and then by 12 months the minimum acceptable level of response is generally a complete cytogenetic response. There are some instances whereby if patients are most of the way there, one can wait till 18 months. So that in essence is a snapshot of the NCCN Guidelines and what is recommended for initial monitoring and response data, but the ELN of course was the first organization to develop these sorts of guidelines which they did back in 2006 and they reevaluated them again in 2009, I believe, and now again in 2013. I thought Dr. Saglio you can tell us a little bit about what has changed from the ELN perspective.
Saglio: Yes, of course, also the ELN has established that the 3 months' cutoff of 10% is a very important point to evaluate the different uses of the patients; however, whereas the NCCN, as you have mentioned, they suggest to switch, meeting the European LeukemiaNet recommendation decided that you can if you want to switch, but you can also wait because at the moment we do not have necessarily data suggesting that this can be very, very useful and still beneficial for the patients. So, this is a very conservative point of view; however, they simply recommended to monitor more carefully these patients because they know that they are at risk, but they cannot recommend an early switch because of lack of data. So essentially, this is the main difference. Of course, there are different positions, even within the members of the European LeukemiaNet panels, there are those who are in favor of switching and those who are in favor of waiting the 6 months' time point, which is becoming also very important to establish at this point having failure for those who are above 10%.
Shah: So, the argument for switching, if I heard you correctly, would be largely based on the data that suggest second-generation inhibitors are in general superior to imatinib and that we have overall survival data that suggests or demonstrates that patients who do not have deep initial molecular response are less likely to be alive a few years down the road. You mentioned the argument against that is that we do not have any data that suggests that if you take patients who failed to meet that milestone and randomize them to either imatinib or a second-generation TKI, there have been no studies showing that the second-generation TKI is superior. To the best of my knowledge, I think those studies are ongoing, but could one also say that we do not have such evidence for failure to achieve a complete cytogenetic response. We do not have randomized studies, but we move ahead with switching patients because we know that the likelihood of doing well, if you do not have a complete cytogenetic response by 12 months or 18 months, your likelihood of doing well on imatinib is compromised substantially. Would you say that that is fair to say?
Saglio: I totally agree with you. I think that this is a very important point that, of course, at least in my personal opinion, it is very difficult to deny that switching patients that we know have an inferior prognosis and that could be, we are not sure, but that could be, improved by switching to a second-generation TKI. Even because this intervention is an intervention not particularly I would say demanding on the side of the patients, and therefore I think that in my personal opinion I am more in favor of the NCCN Guidelines with respect to European LeukemiaNet Guidelines.
Shah: Of course, both of these are available. There has been a publication from the ELN recently in Blood and NCCN Guidelines are available on NCCN website. I would like to switch gears now and ask you about this important update you are going to be presenting today with longer-term follow up of the second-generation agent, the ENESTnd study that compared nilotinib to imatinib in previously untreated patients. What can you tell us about this update?
Saglio: This is an important update because it is the 5-year update, and therefore, this was in origin the end of the study also, but now it has been decided to prolong the study for an additional 5 years, so we will have a 10-year long study, and this is mainly to look for deeper molecular responses which are particularly promising as I would say, and also for side effects, the toxic effect that the TKI assumption can cause on the long-term treatment of these patients. So, what at 5 years can we say on the comparison between imatinib and nilotinib 300 mg? That certainly nilotinib is able to cause more deeper molecular responses, not only really fast molecular responses but also very deep because in terms of MR 4, MR 4.5 in particular, we have now more than enough patients who are treated with nilotinib 300 mg or 400 mg who are already in MR 4.5, which previously was called a complete molecular response, and which is considered the correct procedure to enter to treatment-free remission or, if you like, discontinuation of studies, which means the possibility to remain in complete molecular response even without the drug continuing to consuming the drug. So, I think this is a very, very important point. It also changes a little bit the perspective of the goal that we should achieve in the treatment of CML because it is not simply, I would say, a prolonged overall survival. This probably has been achieved as it is difficult to further improve the results, but certainly one of the goals can be the discontinuation and the true cure of the disease. I think that this is an important point, also because little-by-little, in the long run, we are seeing that there are effects arising with the long-term treatment of CML patients with TKI. These have been observed for nilotinib, in particular cardiovascular events, and indeed in this update there are more cardiovascular events in both nilotinib arms but particularly in the 400 mg twice-a-day arm with respect to the 300 mg arm, with respect to imatinib, but also for harder types of side effects that can affect patients treated with dasatinib and/or with imatinib. So, the idea that probably what we can face is a situation in which a diagnosis, we enroll a patient in a treatment with imatinib and he can remain for the rest of his life in this treatment without any kind of discontinuation and without suffering, however, any kind of side effect is probably not completely substantiated. But what is coming out is an observation period, which is the length maximum is 12 to 13 years. So, I think that in little bit we are opening now a new chapter in the research of both biological and clinical associated CML. We should aim to the real cure of the disease.
Shah: I think you raised an important point about longer follow up because even though as you mentioned the imatinib has been approved for 12 or 13 years, the IRIS study I believe stopped following patients beyond 8 years. That is the longest follow up that has been presented. I am sure you, like I, have these younger patients and we can tell them what we know what 8 years of follow up. If you want to know about 15 years or 20 years, and obviously we do not have that much time yet, but I certainly applaud the decision to extend the follow up of this ENESTnd, this is very important study, from 5 years to 10 years because as you are alluded to, I completely agreed that with longer follow up one wants to know is the efficacy data holding up and more importantly is the toxicity data also holding up because as we have more and more patients, even with imatinib many patients do achieve complete molecular response, and so it is going to be very important to weigh these potential benefits for both these new drugs that are approved in the front-line setting, the nilotinib and dasatinib, with the other risks of potentially serious and irreversible toxicities and there are examples of both those types of things with both these new drugs. So, anything else you would like to tell us about your presentation today?
Saglio: I think that the data which is emerging is very, very striking, is simply represented by the deeper molecular responses, in particular those who are responding very fast are already below 1% after 3 months of therapy, in the ENESTnd study they achieved CMR in 70% of the cases, and this is an extremely important point if you consider that these patients are more than 50% of the total number of the patients. So, according to this number in this rather short period of time, we can enroll in discontinuation studies at least one-third of the similar patients.
Shah: Sounds very promising. I would like to thank Professor Saglio for joining us today, and I would like to thank all of you for taking time to watch this, and I would encourage you to visit the Managing CML website for further information. Thank you very much.
National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines in Oncology (NCCN Guidelines®): Chronic Myelogenous Leukemia. (Version 2.2014) Release date 11/01/2013.
Baccarani M, Deininger MW, Rosti G, et al. European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013. Blood. 2013;122(6):872-84.
Saglio G, et al., ENESTnd Update: Nilotinib (NIL) Vs Imatinib (IM) In Patients (pts) With Newly Diagnosed Chronic Myeloid Leukemia In Chronic Phase (CML-CP) and The Impact Of Early Molecular Response (EMR) and Sokal Risk At Diagnosis On Long-Term Outcomes. [ASH Annual Meeting Abstracts] Blood. 2013;122(21):Abstract: 92.


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