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Edited by: Giovanna Orsini, Marche Polytechnic University, Italy
Reviewed by: Barbara Zavan, University of Padua, Italy; Alessandra Pisciotta, University of Modena and Reggio Emilia, Italy
†These authors have contributed equally to this work and share first authorship
This article was submitted to Stem Cell Research, a section of the journal Frontiers in Cell and Developmental Biology
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Bone formation, in skeletal development or in osseointegration processes, is the result of interaction between angiogenesis and osteogenesis. To establish osseointegration, cells must attach to the implant in a direct way without any deposition of soft tissue. Structural design and surface topography of dental implants enhance the cell attachment and can affect the biological response. The aim of the study was to evaluate the cytocompatibility, osteogenic and angiogenic markers involved in bone differentiation of human periodontal ligament stem cells (hPDLSCs) on different titanium disks surfaces. The hPDLSCs were cultured on pure titanium surfaces modified with two different procedures, sandblasted (Control—CTRL) and sandblasted/etched (Test—TEST) as experimental titanium surfaces. After 1 and 8 weeks of culture VEGF, VEGF-R, and RUNX2 expression was evaluated under confocal laser scanning microscopy. To confirm the obtained data, RT-PCR and WB analyses were performed in order to evaluate the best implant surface performance. TEST surfaces compared to CTRL titanium surfaces enhanced cell adhesion and increased VEGF and RUNX2 expression. Moreover, titanium TEST surfaces showed a different topographic morphology that promoted cell adhesion, proliferation, and osteogenic/angiogenic commitment. To conclude, TEST surfaces performed more efficiently than CTRL surfaces; furthermore, TEST surface results showed them to be more biocompatible, better tolerated, and appropriate for allowing hPDLSC growth and proliferation. This fact could also lead to more rapid bone–titanium integration.
In the last few years, mesenchymal stem cells (MSCs) have been performing a primary function in regenerative medicine and tissue engineering. They offer the opportunity to restore, recover, and renovate cells, tissues, and organs (
The protocol and informed consent from human periodontal ligament biopsies were accepted by the Medical Ethics Committee at the Medical School, "G. d'Annunzio" University, Chieti, Italy (no. 266/17.04.14). The formal consent form was subscribed by all patients prior to sample collection. The Department of Medical, Oral and Biotechnological Sciences and the Laboratory of Stem Cells and Regenerative Medicine are certified in accordance with the quality standard ISO 9001:2015 (certificate no. 32031/15/S).
Five human periodontal ligament biopsies were scraped from human premolar teeth of patients in general good health conditions. The tissue was obtained by scaling the roots using Gracey's curettes (
The study of hPDLSC phenotype was performed by flow cytometry, as earlier stated (
In the current work, two different titanium disk surfaces, provided by Implacil De Bortoli (São Paulo, Brazil), have been utilized: Control (CTRL) and Test (TEST). The disks were manufactured of commercially pure titanium (ASTM F67). The surface of CTRL disks was obtained by sandblasting with a mix of titanium oxide power and then cleaning with purified water, enzymatic detergent, acetone, and alcohol, while the surface of TEST disks, after the same sandblasting procedure, was cleaned with purified water, enzymatic detergent, acetone, alcohol, and then a double acid attack with acetylic acid.
The morphologies of two disk surfaces, CTRL and TEST, were assessed by Atomic Force Microscopy (AFM), exploiting a Multimode 8 Bruker AFM microscope (Bruker, Milan, Italy) coupled with a Nanoscope V controller (Bruker AXS, Marne La Vallee, France) and commercial silicon tips (RTESPA 300, resonance frequency of 300 kHz, and nominal elastic constant of 40 N/m) were used in ScanAsyst air mode. The ScanAsyst air mode technique was used for the AFM observations with a scan size of 10 μm. Then the Nanoscope analysis 1.8 software was adopted to analyze images and 3D reconstruction. The roughness average (Ra), that is the arithmetic mean of the absolute values of the height of the surface profile, was assumed for the statistical analysis. Five samples of each group were analyzed, and the mean values (±standard deviation) were considered for statistical analysis (
CTRL and TEST samples were cultured with hPDLSCs for 21 days and successively were fixed for 4 h at 4°C in 4% Glutaraldehyde in 0.05 M phosphate buffer (pH 7.4), dehydrated in growing ethanol concentrations, and then critical point dried. They were then mounted on aluminum stubs and gold coated in an Emitech K550 (Emitech Ltd., Ashford, United Kingdom) sputter coated before imaging by means of SEM (ZEISS, EVO 50) (
The cell viability of hPDLSCs seeded with or without CTRL and TEST samples was measured by the quantitative colorimetric MTT [3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazoliumbromide test] (Promega, Milan, Italy) as earlier described (
After 1 and 8 weeks of cultures on both CTRL and TEST titanium surfaces, calcium deposition and extracellular matrix mineralization were evaluated by ARS staining assay. This analysis was executed according to the method previously described (
Cells grown on CTRL and TEST samples were fixed for 10 min at room temperature (RT) with 4% paraformaldehyde in 0.1 M sodium phosphate buffer (PBS), pH 7.4 (
VEGF and RUNX2 mRNA expressions were assessed by real-time PCR. For this purpose, total RNA was isolated utilizing the Total RNA Purification kit (NorgenBiotek Corp., Thorold, ON, Canada) in agreement with the manufacturer's instructions (
Thirty micrograms of proteins, acquired from all samples, were processed as earlier mentioned (
The Statistical Package for Social Science (SPSS, v.21.0, Inc., Chicago, IL, United States) was used for data analysis. Parametrical methods were used after having verified the existence of the required assumptions. In particular, the normality of the distribution and the equality of variances were assessed by the Shapiro–Wilk and Levene's tests, respectively. Data were expressed as means and standard deviation of the recorded values. The differences among the levels of the factors under investigation were assessed performing three distinct two-way ANOVA tests, one for each experiment. Tukey tests were applied for pairwise comparisons. A value of
The two titanium disks surfaces, CTRL and TEST, were analyzed by utilizing AFM. In
Implant surface evaluation. 3D reconstruction of atomic force microscopy (AFM) images of
For the purpose of evaluating the hPDLSC phenotype, flow cytometry analysis was performed on stem cells at the second passage.
Human periodontal ligament stem cell (hPDLSC) characterization.
Cell adhesion has been evaluated by SEM and CLSM techniques. SEM observations evidenced the surface morphology of two distinct, taken into consideration, surfaces, CTRL and TEST, without cells (
Scanning electron microscopy (SEM) analysis showed the hPDLSCs' adhesion capacity to the titanium implant surfaces.
Human PDLSCs seeded on CTRL
MTT assay was performed at 24, 48, 72 h, and 1 week on both CTRL and TEST titanium surfaces. The hPDLSCs seeded on the TEST surface showed after 24 and 48 h a slightly higher proliferation rate compared to cells seeded on the CTRL surface and control cells. Cell cultured on the CTRL and TEST surface after 72 h and 1 week of culture showed a similar proliferation rate of control cells (
Proliferation assay of hPDLSCs seeded on CTRL and TEST titanium surfaces. MTT assay was evaluated at 24, 48, 72 h, and 1 week on both CTRL and TEST titanium surfaces. The human PDLSCs seeded on TEST surface showed after 24 and 48 h a slightly higher proliferation rate compared to cell cultured on CTRL surface and control cells. Cells cultured on CTRL and TEST surface after 72 h and 1 week of culture showed a similar proliferation rate of control cells. Proliferation was assessed using [3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazoliumbromide test] (MTT) assay. The data shown are the mean (±SD) (
The osteogenic process in human PDLSCs, seeded with CTRL and TEST titanium surfaces after 1 week (
Human PDLSCs seeded on CTRL and TEST titanium implant surface were analyzed after 1 and 8 weeks of culture by Alizarin Red S staining (ARS).
A significant augmented extracellular deposition was evident in cells grown after 8 weeks on the CTRL and TEST titanium surfaces compared to that of cells seeded on both surfaces after 1 week of culture (
Human PDLSCs seeded on CTRL titanium implant surface were analyzed after 1 week of culture.
Human PDLSCs cultured on CTRL titanium implant surface were observed after 8 weeks of culture.
Human PDLSCs cultured on TEST titanium implant surface were observed after 1 week of incubation.
Human PDLSCs cultured on TEST titanium implant surface were observed after 8 weeks of incubation.
Graph bar evidence the percentage of positive cells for the specific markers (VEGF/VEGF-R/RUNX2). The error bars on these graphs showed standard deviation (±SD). ∗∗
Histograms evidenced the gene expression of VEGF and RUNX2 performed by RT-PCR after 8 weeks of culture (
To identify protein expression of VEGF and RUNX2 in hPDLSCs seeded on CTRL and TEST after 8 weeks of culture, a Western blot analysis was performed. Protein expression of specific bands of VEGF and RUNX2 exhibited an over expression in hPDLSCs seeded on TEST with respect to the cells cultured on CTRL (
Recently, novel treatment techniques of titanium surfaces were suggested and tested to increment the clinical performance, and to decrease the percentage of clinical unsuccessful attempts. The endeavors of scientific research were primarily concentrated to ameliorate the quantity and quality of bone tissue healing around implant surfaces and to increase the contact area between the implant surface and the bone tissue. All approaches were relatively surface treatments, adopted recently, driven to specific micro-structured surfaces with a better performance, liked to a greater contact area with the bone, have the capability to absorb biological molecules, induce more rapid healing, augmenting the cellular reaction and long-term clinical successes. Sandblasted and acid-etched surfaces have shown good biomechanical and biological results (
In the current work, the observance was focused on the
The present results indicated that both surfaces, in contact with hPDLSCs, have shown not only osteoconductive properties, evaluated through the cell adhesion and proliferation, but also the ability to promote VEGF secretion from cells evidenced by gene expression and confocal microscopy. The induction of the release of VEGF and VEGF-R from hPDLSCs may represent an expectation for tissue engineering and, in particular, for the therapeutic growth of novel blood vessels surrounding the biomaterial in the first phase of osseointegration. In two recent studies,
The datasets generated for this study are available on request to the corresponding author.
The studies involving human participants were reviewed and approved by the Medical Ethics Committee at the Medical School, "G. d'Annunzio" University, Chieti, Italy (no. 266/17.04.14). The patients/participants provided their written informed consent to participate in this study.
GM, FD, JP, and OT: conceptualization. LF and IM: formal analysis. FD, GM, and IM: investigation. GM, FD, LF, and IM: methodology. LF and JP: software. AP, OT, and SP: supervision. GM and FD: writing—original draft. EM, AP, SP, and OT: writing—review and editing.
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
The Supplementary Material for this article can be found online at:
Western blot specific bands.


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Golf tournament contract may be extended: Anouncement expected Friday
American Century Championship officials may extend the contract established between the so-named investment firm, NBC Sports, Lake Tahoe Visitors Authority and Harrah's Lake Tahoe.
An announcement is expected to be made Friday morning about the relationship that has taken the premier South Shore event into its 18th year.
NBC Sports holds an agreement with American Century to stage the golf tournament through 2008. It's contract with LTVA and the casino runs through 2010.
The tournament, which starts this week and ends Sunday at Edgewood Tahoe Golf Course, features some of the biggest names in sports and entertainment, including actor Kevin Costner playing for the first time in the LTVA Celeb/Am Tournament today, and Tour de France cycling great Lance Armstrong expected to appear on Thursday.
Basketball stars Michael Jordan and Charles Barkley will join soccer sensation Brandi Chastain and Seinfeld actor John O'Hurley.
Television coverage is set for Friday, Saturday and Sunday on ESPN2 and NBC. More than 6 million viewers are expected to tune in.
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The Natural Local Virtual Education
Midnight weekend screenings happen on Friday & Saturday nights (meaning arrive on Friday and/or Saturday night by 11:45pm for seating, the movie starts after midnite)!
Run Time: 60 min.
Virtual Education Seminar "The Natural" with guest author Dennis Snelling
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chapter 3
15 Pages
Forming words and compounds
In Turkish, words are built almost exclusively by suffixation. Words can have a sequence of suffixes and can correspond to a whole sentence in English:
gör-üs¸-tür-ül-me-mis¸-ti-k 'we hadn't been allowed to see each other'
var-lık-lı-las¸-tır-ıl-a-ma-yabil-ir-ler 'they may not be able to be made rich'
al-ıntı-lan-dır-a-ma-dıg˘-ımız-dan-dır 'it must be because we cannot quote [it]'
It is very important to get the order of the suffixes and the sounds right. The order of the nominal and the verbal suffixes is discussed in Chapters 4 and 16 respectively.


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For me, when SEO is more important than branding, the company name goes at the end of the tag, and I use a variety of dividers to separate as no one way performs best. If you have a recognisable brand – then there is an argument for putting this at the front of titles – although Google often will change your title dynamically – sometimes putting your brand at the front of your snippet link title itself. I often leave out branding. There is no one size fits all approach as the strategy will depend on the type of page you are working with.
QUOTE: "To summarize, a lack of helpful SC may be a reason for a Low quality rating, depending on the purpose of the page and the type of website. We have different standards for small websites which exist to serve their communities versus large websites with a large volume of webpages and content. For some types of "webpages," such as PDFs and JPEG files, we expect no SC at all." Google Search Quality Evaluator Guidelines 2017
The above information does not need to feature on every page, more on a clearly accessible page. However – with Google Quality Raters rating web pages on quality based on Expertise, Authority and Trust (see my recent making high-quality websites post) – ANY signal you can send to an algorithm or human reviewer's eyes that you are a legitimate business is probably a sensible move at this time (if you have nothing to hide, of course).
Social media marketing and SEO go hand-in-hand. Social media is a growing forum for communication with customers and for advertising products and services. Creative, viral social content projects may create brand discussions and awareness. As more people talk about our clients, more people visit their sites, become customers and link to their sites.
"Doorways are sites or pages created to rank highly for specific search queries. They are bad for users because they can lead to multiple similar pages in user search results, where each result ends up taking the user to essentially the same destination. They can also lead users to intermediate pages that are not as useful as the final destination.
QUOTE: "high quality content is something I'd focus on. I see lots and lots of SEO blogs talking about user experience, which I think is a great thing to focus on as well. Because that essentially kind of focuses on what we are trying to look at as well. We want to rank content that is useful for (Google users) and if your content is really useful for them, then we want to rank it." John Mueller, Google 2016
And you've got to diversify. Here's a tongue-twister that's absolutely true: diversity is a key word in the keyword world. You're not going to stand out if you find yourself using all of the same keywords as your competitors. Not only should you try new keyword search tools and keep track of the results, but you should feel free to experiment based on your own research – who else uses your keywords? And how do you make yourself stand out? By providing great content that truly answers the questions your prospective customers are asking with their keyword searches.


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How the adventure ended will be seen anon. Aouda was anxious, though she said nothing. As for Passepartout, he thought Mr. Fogg's manoeuvre simply glorious. The captain had said "between eleven and twelve knots," and the Henrietta confirmed his prediction.
If, then—for there were "ifs" still—the sea did not become too boisterous, if the wind did not veer round to the east, if no accident happened to the boat or its machinery, the Henrietta might cross the three thousand miles from New York to Liverpool in the nine days, between the 12th and the 21st of December. It is true that, once arrived, the affair on board the Henrietta, added to that of the Bank of England, might create more difficulties for Mr. Fogg than he imagined or could desire.
During the first days, they went along smoothly enough. The sea was not very unpropitious, the wind seemed stationary in the north-east, the sails were hoisted, and the Henrietta ploughed across the waves like a real trans-Atlantic steamer.
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"Empirical Method for Detecting Pointing Gestures in Recorded Lectures."
Xiaojie Zha, Marie-Luce Bourguet (2016)
- Xiaojie Zha, Marie-Luce Bourguet:
Empirical Method for Detecting Pointing Gestures in Recorded Lectures. SUI 2016: 195
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Breaking Business News | Breaking business news AM | Breaking Business News PMShould You Pawn Your Valuables?
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A Comprehensive Overview of AIIMS Nursing Application Form
AIIMS is considered to be the best medical institution in India, not just in terms of its offered treatment but also because of the offered courses which include nursing too. Understandably, the number of seats provided by this institution across its 7 branches are quite limited - 477 basic seats and 25 post-basic seats being available. With widespread uncertainty erupting over AIIMS nursing 2020 due to this Covid-19 pandemic, students need to note essential dates even if some of them are tentative ones. Furthermore, as an aspirant, you should also note every detail regarding AIIMS nursing application form to avoid any chance of missing out or cancellation.
Before moving on to AIIMS BSc nursing 2020 application form and document requirements, aspirants of this course should note the important dates related to it. These are mentioned in detail in this table below.
Notably, with the outbreak of novel coronavirus, there can be upheaval in this date schedule. As a result, students should keep a tab on updates and notifications to be aware of revised dates.
AIIMS Nursing Application Document Requirements
Aspirants looking to join AIIMS should also note these documents mentioned below which must accompany BSc nursing 2020 application forms. These must be submitted to generate the hall ticket for the said entrance examination.
Certificate of an applicant's category.
Qualifying examination marksheet.
Valid photo-identity proof.
Credentials of financial account for net banking or credit/debit card.
Photograph of the candidate which should also follow these specifications listed below.
Image size must be within 50 and 100kb.
Photographs should have a white background and must be taken under bright light.
The front profile of this candidate appearing for AIIMS nursing 2020.
This photograph should be of standard size (3.5cm by 4.5cm).
This image should be in JPEG/JPG/PNG/GIF format.
Image of the candidate's signature which should also follow these specifications mentioned below.
Signature should be on a white paper and duly scanned.
Size of this image should be in between 20 and 100kb.
Original signature should follow the dimensions 3cm by 6cm.
This image should be in JPEG/JPG/PNG/GIF format.
Thumb impression with specifications same as that of a candidate's signature.
Steps to Follow While Filling AIIMS Nursing Application Form
Aspirants must follow these steps explained below while filling their AIIMS nursing application form. While this form should be double-checked before submission, in case there is an error in it, you can also edit it later.
However, once this date as mentioned earlier for revision of AIIMS BSc nursing 2020 application form has passed, your form cannot be modified. It will stand rejected due to incorrect information.
Basic registration for BSc nursing 2020
Online registration in the official website
Scanning and uploading of relevant images including candidate's photograph, signature and thumb impression.
Generating RUC.
Final registration of BSc nursing 2020 application form
Form fill-up which includes academic and related details.
Valid contact details of candidates.
Fee payment
Online application fee payment.
Choice of examination centre.
AIIMS nursing 2020 confirmation
The AIIMS Bsc nursing 2020 application fees for various categories of candidates are mentioned in this given table.
Important to note, candidates might have to pay an additional transactional charge, depending on their mode of payment.
Currently, there are 14 centres across India where AIIMS nursing 2020 candidates can appear for their entrance examination. These are listed in this table underneath.
Prepare and Apply For the Best Nurse Training At AIIMS
Preparation for BSc nursing 2020 should have begun with your standard 10 + 2 curricula, and now it is time you put the final touches to it. While this deterrence due to Covid19 has brought in uncertainty, you should also use this time to enhance your preparation and brush up any topic which is under-prepared. Along with it, do not forget to revise the rest of your AIIMS nursing 2020 curriculum regularly. Once you have completed your basic and final registration, all you must focus on is that of your syllabus.
Finish your syllabus, complete registration-related procedures and keep revising. Your results are only in your hand!
1. What is PAAR facility in AIIMS nursing application?
PAAR or Prospective Aspirants Advanced Registration facility has been introduced in AIIMS Bsc nursing 2020 to reduce the total number of rejections in this course. Under this process, aspirants have to complete a 2 step registration process which has been termed as basic and final registration.
2. How is nursing basic and post-basic courses different in terms of eligibility criteria?
While both these examinations require its candidates to pass their standard 12 examinations with Physics, Chemistry and Biology, post-basic courses also require a diploma in midwifery and general nursing. In the case of basic nursing courses, only female candidates are allowed, though in post-basic courses male candidates are also permitted.
3. What is the examination pattern for AIIMS BSc nursing entrance examination?
The AIIMS nursing 2020 exam is to be conducted online in English. The question papers are usually divided into 4 sections of which Physics, Chemistry and Biology have 30 marks each, while general knowledge carries 10 marks. A 2-hour examination with MCQ based questions; it also has a negative marking of ⅓ marks for every wrong answer.


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Imo State Governor, Owelle Rochas Okorocha has stated that President Muhammadu Buhari's declaration to seek re-election in 2019 is a patriotic response to the clarion call of Nigerians of goodwill for him to lead the Country for another 4 years.
The governor said the President has done well to deserve second tenure and he expressed optimism that the President would largely garner more votes in 2019 than he had done in 2015 because most Nigerians, including people of the South-East have seen that he meant well for the nation and her Citizenry.
Rochas said the APC has no apology to make because it has done wonderfully well considering the magnitude of the rot it met on ground in 2015 and noted that the antenna of the opposition in the Country will finally be lowered when the campaigns begin and the Party will be showing Nigerians its achievements in the States under its control and at the federal level.
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Originally placed in the Casaya tribe consisting of older ladies, she was on the chopping block when they misplaced the very initial immunity problem. However, Fields was able to get Melinda Hyder and Ruth-Marie Milliman to boot Tina Scheer. She stayed on Casaya (Bayoneta and Viveros were disbanded, leaving La Mina as the only opponent) after the schoolyard select in the following episode, and was targeted due to her lack of physical ability but saved once more when Melinda was voted out first.
After the merge, she remained safe as the former La Mina members, Nick Stanbury, Austin Carty, and Sally Schumann were voted out. Cirie proved her observance skills after winning a advantage challenge and chose to bring Aras Baskauskas and Danielle with her, while banishing Terry to Exile Island. While on her reward, original Casaya member Bruce Kanegai was evacuated for a blocked digestive method, propelling Cirie and the others to the final six. She formed two dummy alliances, one with Courtney and Terry (to target Aras), and one with Shane Powers (to target Danielle). Then she got Aras and Danielle to vote out the real target, Courtney, due to her being the least likeable with everyone (including the jury). In the final five, Cirie was able to regain trust with Shane, but ultimately decided to convince Aras and Danielle to blindside him when Terry won immunity again. Shane later said that Cirie played "by far the very best social game" of the season, an observation numerous fans and critics strongly agreed with.
|Cirie Fields
|Date of Birth
|Place of Birth
|Newark, New Jersey, U.S.
|Famous for


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The 20 Keys to Workplace Improvement is well known with Kaizen lessons and the whole Agile people group. "20 Keys to Workplace Improvement" is a book by Iwao Kobayashi who portrays his perspectives on the advancement of work and procedures underway exercises.
Numerous years after the fact, the whole Agile industry shared this Kaizen educating and referred to the 20 keys to working environment improvement. Reference: Modern Kaizen standards and keys to workforce improvement, www.vbprojects.org
The article records all the first subjects, however gives clarifications to every point and offers subtleties and potential techniques for chiefs following Kaizen standards.
Before sharing the 20 keys of Iwao Kobayashi, I might want to begin with the proviso that they are on the whole critical for improving crafted by the association. Or maybe, we may believe that beginning with specific advances would make it simpler for us to proceed onward to improve the following ones.
Improving work and the board is a procedure where the two administrators and representatives must be included. The degree of hierarchical culture in the organization and the administration of HR assume a critical job in this procedure on the grounds that the individuals in the organization are the ones who roll out the improvements to improve things.
Full Article URL: https://ossalumni.org/kaizen-and-the-20-keys-to-workplace-improvement-of-iwao-kobayashi-real-examples/


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TV Series | TV-14 | | Action, Crime, Drama
"1-8-7" is the Los Angeles police code for murder or death. Detroit police do not have a code for murder or death.
187 is the California Penal Code for homicide. In Michigan, the various forms of homicide start with 750.
Freshen up your watchlist with Prime Video's latest roster of streaming movies and TV shows, featuring some great throwbacks and top-notch newcomers.


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While many forex traders prefer intraday trading, because market volatility provides more opportunities for profits in narrower time-frames, forex weekly trading strategies can provide more flexibility and stability. A weekly candlestick provides extensive market information. It contains five daily candlesticks, and changes which reflect the actual market trends. Weekly forex trading strategies are based on lower position sizes and avoiding excessive risks.
A forex trading strategy works really well when traders follow the rules. But just like anything else, one particular strategy may not always be a one-size-fits-all approach, so what works today may not necessarily work tomorrow. If a strategy isn't proving to be profitable and isn't producing the desired results, traders may consider the following before changing a game plan:
The information on Forex Factory is sourced in from Fair Economy and relayed in real time. Micro movements are also monitored by the broker partners of the platform. Forex Factory follows standard candlestick charts of multiple durations ranging from 1 minute to 1 month. There are 28 forex instruments available to trade on Forex Factory that are offered by its different broker partners.
Trend-following systems require a particular mindset, because of the long duration—during which time profits can disappear as the market swings—these trades can be more psychologically demanding. When markets are volatile, trends will tend to be more disguised and price swings will be greater. Therefore, a trend-following system is the best trading strategy for Forex markets that are quiet and trending.
This method is all about analyzing important news happenings on different fronts in a nation and understanding the implications that they will have on the currency market. The trader will then place the trades accordingly. The market moves in an unpredictable manner when there are sudden political or economic happenings in any nation. As the forex market operates round the clock, news flows in from all parts of the world. Trading on the basis of economic news and data suits all kinds of traders wherever they are and whichever currency they choose to trade.
Why should you use Learn to Trade to learn Forex trading? That's simple: we are a credible, well-established organisation that exists to educate people on Forex trading strategies. Our Forex trading training is second to none and will give you the foundation you need to achieve success in the high-opportunity world of currency trading. Every course is supported by our knowledgeable team of experts, who guide and support you throughout your learning experience. Not only that – you'll get to take advantage of our live trading floor to get some hands-on experience. Getting a feel for what it's like, while you have experienced traders around to help you, is a valuable opportunity that will help you get the confidence you need. Register now for your Forex trading tutorial and workshop!
Any nation's central bank, adjusts the rates of interest from time to time in order to contain or curb the inflationary trends. This, in turn, has a definitive effect on the currency market and traders assume trading positions accordingly. The central bank of a country does not act as it is a solid body. The interest rate is increased or decreased based on the vote cast by the members of the monetary policy committee. The number of members monetary committee varies from one bank to another. If the interest rate is cut, there will be more money in circulation. This makes it cheaper. If the interest rate is hiked, its value increases.
Some of these factors include political stability, interest rates, inflation, terms of trade, public debt and current account deficits. For example, in the case of interest rates, if rates are higher, lenders get a better return compared to those in a country with lower rates; therefore the higher rates attract foreign capital which causes the exchange rate to rise. This is one of the reasons forex traders may look to trade on interest rate announcements from central banks like the US Federal Reserve or the Bank of England.
Political instability and poor economic performance can also have a negative impact on a currency. Politically stable countries with robust economic performance will always be more appealing to foreign investors, so these countries will draw investment away from countries characterised by more economic or political risk. Furthermore, a country showing a sharp decline in economic performance will experience a loss of confidence in its currency and a movement of capital to currencies of more economically steady countries. These are just two simple examples of what can affect foreign exchange rates and the kind of things traders consider when developing forex trading strategies.
Leveraged trading in foreign currency or off-exchange products on margin carries significant risk and may not be suitable for all investors. We advise you to carefully consider whether trading is appropriate for you based on your personal circumstances. Forex trading involves risk. Losses can exceed deposits. We recommend that you seek independent advice and ensure you fully understand the risks involved before trading.
High Risk Warning: Forex, Futures, and Options trading has large potential rewards, but also large potential risks. The high degree of leverage can work against you as well as for you. You must be aware of the risks of investing in forex, futures, and options and be willing to accept them in order to trade in these markets. Forex trading involves substantial risk of loss and is not suitable for all investors. Please do not trade with borrowed money or money you cannot afford to lose. Any opinions, news, research, analysis, prices, or other information contained on this website is provided as general market commentary and does not constitute investment advice. We will not accept liability for any loss or damage, including without limitation to, any loss of profit, which may arise directly or indirectly from the use of or reliance on such information. Please remember that the past performance of any trading system or methodology is not necessarily indicative of future results.
Forex traders evaluate currencies and the countries much like how equities and companies are evaluated to get a clear idea of the currency's value. The value of a currency changes due to many factors such as economic growth of the nation and its financial strength. All this information is analyzed by the forex traders to evaluate the value of its currency. Fundamental trading strategies cannot be easily mastered by a newbie forex trader. Given below are some trading methods that use fundamental analysis.


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|August 10, 1977
Highway Racer brings all of you to immerse yourself into the adrenalin rush of dangerous driving. Now download it free for PC and try to win racing competitions. Remember that the more you put your car at risk, the higher rate you win.
It is a fact that the authors of this game designed it to bring players a feeling of the adrenalin as well as the interest of driving recklessly. Of course, it is only a game, not in real life. As a result, you are able to do it without worrying about any danger. To start things off, select the car you love, customize it to your preference, and then hit the road.
Specifically, in this game, you are possible to make use of various tactics and different maneuvers in order to obtain points as well as keep you on the track:
Try to block police cars chasing you. Notice that you can see them via your side mirrors.
The nearer you race past other cars, the more points you get
Attempt to increase and reach higher speeds in order to get more points.
You can drive your car in the opposite direction in order to receive more points.
Remember to brake to avoid accidents if necessary.
If you want to become a reckless racer without any danger, don't hesitate to get Highway Racer free download for PC!


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RoHS | January 12, 2007
How reliable is your leadfree solder joint?
IPC and Soldertec hosts leadfree seminars in San Sebastian, Spain in March. The question in focus is: "Can i rely on my leadfree solder joint?"
After years with thousands of seminars, workshops and conferences around the electronics world including predictions and warnings about the consequences of the lead ban, we have now, 6 months after the implementation of the RoHS directive, reached the point where many companies with high quality electronic products realise that transferring to lead free soldering production will not necessarily be a piece of cake. IPC and Soldertec Global have accepted the challenge and taken a firm grip on the subject of Reliability. A number of experts in the reliability field have been engaged such as Jean-Paul Clech who will give an in-depth review of "Lead Free Solder Joint Reliability" and Dr. Yoshiharu Kariya, active at the Shibaura Institute of Technology, presenting "Fatigue Characteristics of Lead free Solder Alloys". A number of European experts from the ELFNET project, including IMEC, Ericsson, IVF, EMPA and the Fraunhofer Institute will detail the latest European perspective.


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Had your bike stolen? Lost an expensive watch? You can now report it online
Coquitlam RCMP is now ready to accept your non-emergency crime reports online. If you have a valid email address, you can now visit our secure site and report many crimes that have happened in Anmore, Belcarra, Coquitlam or Port Coquitlam.
Emergencies must still be reported to 911, but here are the types of crime you can now report as part of Online Crime Reporting (OCR):
- Something is stolen that costs less than $5000
- You lost something that costs less than $5000
- Your property or vehicle has been vandalized & repairs will cost less than $5000
- The crime happened in Anmore, Belcarra, Coquitlam or Port Coquitlam
- You have a Driving Complaint that is not happening right now
Online Crime Reporting is ideal for crimes that involve lost items and damage. As you report, it will guide you through the process and determine if your crime fits the criteria or if you need to call police. If you have a witness or you found a piece of identification, for example, you will need to call the non-emergency number instead at 604-945-1550.
Coquitlam RCMP uses crime data from your reports to direct and deploy our police officers. Not only does OCR give you another option for reporting crime, it also allows our call takers and officers to focus on emergency calls, rather than taking reports, which should improve overall safety and response times.
Crime reports from the public are an essential part of determining how our policing resources are deployed across the communities we serve, says Corporal Michael McLaughlin with Coquitlam RCMP.
Online Crime Reporting will make it more convenient to report less serious crimes, while allowing police to better triage emergency calls for service and accurately track crime trends.
To make a report using the Online Crime Reporting tool visit bc.rcmp-grc.gc.ca/coquitlam/report
Released by:
Corporal Michael McLaughlin
Media Relations Officer
Coquitlam RCMP
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On most weeken[d]s the effective feerate drops to 1/2 satoshi/byte... [?!?!] basically nothing-- which is how traffic will be on most weekdays if there is only a bit more capacity.
Miners could trigger a doubling of the network's capacity with no disruption in ~2 weeks, the software for it is already deployed all over the network-- on some 90%+ of nodes (though 20% would have been sufficient!), miners need only make a trivial configuration change [SegWit] [?!?!]
(3) Here's the sickest, dirtiest lie ever from Blockstream CTO Greg Maxwell u/nullc: "There were nodes before miners." This is part of Core/Blockstream's latest propaganda/lie/attack on miners - claiming that "Non-mining nodes are the real Bitcoin, miners don't count" (their desperate argument for UASF)https://np.reddit.com/btc/comments/6cega2/heres_the_sickest_dirtiest_lie_ever_from/
Core Segwit – Thinking of upgrading? You need to read this!~ u/Windowly (link to article on wallstreettechnologist.com)
SegWit is not great~ u/deadalnix (link to [his blog post](www.deadalnix.me/2016/10/17/segwit-is-not-great/))
Here is a list (on medium.com) of 13 articles that explain why SegWit would be bad for Bitcoin.~ u/ydtm
Is it me, or does the segwit implementation look horribly complicated.~ u/Leithm
Bitcoin Scaling Solution Segwit a "Bait and Switch", says Roger Ver~ u/blockologist
Segwit cannot be rolled back because to non-upgraded clients, ANYONE can spend Segwit txn outputs. If Segwit is rolled back, all funds locked in Segwit outputs can be taken by anyone. As more funds gets locked up in segwit outputs, incentive for miners to collude to claim them grows.~ u/BiggerBlocksPlease
SegWit false start attack allows a minority of miners to steal bitcoins from SegWit transactions~ u/homerjthompson_
Blockstream Core developer luke-jr admits the real reason for SegWit-as-soft-fork is that a soft fork does not require consensus, a hard fork would require consensus among network actors and "that it[SegWit] would fail on that basis."~ u/blockstreamcoin
If SegWit were to activate today, it would have absolutely no positive effect on the backlog. If big blocks activate today, it would be solved in no time.~ u/ThomasZander
Segwit is too complicated, too soon~ u/redmarlen
"Regarding SegWit, I don't know if you have actually looked at the code but the amount of code changed, including consensus code, is huge."~ u/realistbtc
Segwit: The Poison Pill for Bitcoin~ u/jEanduluoz
3 excellent articles highlighting some of the major problems with SegWit: (1) "Core Segwit – Thinking of upgrading? You need to read this!" by WallStreetTechnologist (2) "SegWit is not great" by Deadalnix (3) "How Software Gets Bloated: From Telephony to Bitcoin" by Emin Gün Sirer~ u/ydtm
Segwit as a soft-fork is not backward compatible. Older nodes do not continue to protect users' funds by verifying signatures (because they can't see these). Smart people won't use SegWit so that when a "Bitcoin Classic" fork is created, they can use or sell their copies of coins on that fork too~ u/BTC_number_1_fan
jtoomim "SegWit would require all bitcoin software (including SPV wallets) to be partially rewritten in order to have the same level of security they currently have, whereas a blocksize increase only requires full nodes to be updated (and with pretty minor changes)."~ u/specialenmity
Segwit requires 100% of infrastructure refactoring~ u/HermanSchoenfeld
Segwit is too dangerous to activate. It will require years of testing to make sure it's safe. Meanwhile, unconfirmed transactions are at 207,000+ and users are over-paying millions in excessive fees. The only option is to upgrade the protocol with a hard fork to 8MB as soon as possible.~ u/Annapurna317
You've been lied to by Core devs - SegWit is NOT backwards compatible!~ u/increaseblocks (quoting @olivierjanss on Twitter)
"SegWit encumbers Bitcoin with irreversible technical debt. Miners should reject SWSF. SW is the most radical and irresponsible protocol upgrade Bitcoin has faced in its history. The scale of the code changes are far from trivial - nearly every part of the codebase is affected by SW" Jaqen Hash'gharhttps://np.reddit.com/btc/comments/5rdl1j/segwit_encumbers_bitcoin_with_irreversible/
Blockstream having patents in Segwit makes all the weird pieces of the last three years fall perfectly into place~ u/Falkvinge (Rick Falkvinge, founder of the first Pirate Party)
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The Bitcoin Cash supporter Rick Falkvinge said that the Lightning Network (LN) will never be production ready. He has also said that it is a project "dead end for all intents and purposes." The Lightning Network is the off-chain scaling solution that Bitcoin (BTC) developers are working on to help Bitcoin scale. Bitcoin Cash is the digital currency that implemented scaling solutions on-chain. Trending. Conflux Blockchain Announces Ecosystem Grants Program; Fan Victor – The Ultimate Fantasy Sports Plug-in; As US Banks Running Out of Coins Bitcoin Keeps On Chugging Along Rick Falkvinge. Twisting the knife a bit, he writes, "Bitcoin Cash is a meta-organization composed of many different development teams. The Bitcoin Cash organization has no titles other than those which we make up for fun in the spur of the moment, or to make fun of the organizations of the old world that care for titles." Rick Falkvinge Brings Clarity To Bitcoin Debate With 'Rick Reacts' The debate between proponents of Bitcoin Cash and the supporters of Bitcoin Core rages on as gaps within the cryptocurrency community continue to widen.There has been mounting hostility and confusion as unnecessary uncertainty for new crypto enthusiasts leads to aggressive mudslinging especially from the supporters of Bitcoin-Experte Rick Falkvinge schätzt den potenziellen Marktwert auf 100.000 bis 1 Mio US-Dollar pro Bitcoin. Bei einer solchen Wertsteigerung würde wohl die Dezimalstelle nach vorn […] How much is a bitcoin worth?
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How to Import & Use Paper Wallets for Beginners by Crypto Tips. 6:37. ... Rick Falkvinge "BITCOIN will be BIGGER than the OIL INDUSTRY" 💰⛽ by YON WORLD. 10:27. In today's clip, Rick explains the downfall of Blockstream (the company) from a business perspective. Connect With Rick on Twitter: @Falkvinge Bitcoin trading Bitcoin value Bitcoin wallet Bitcoin blockchain Blockchain Satoshi Nakamoto Digital currency. ... BITCOIN WILL HIT $5 MILLION - Rick Falkvinge London Real - Duration: 4:54. BITCOIN WILL HIT $5 MILLION - Rick Falkvinge London Real - Duration: 4:54. London Real 296,156 views. 4:54. Andreas Antonopoulos - Bitcoin - PART 1/2 London Real - Duration: 46:47. Bitcoin and the Blockchain Rick Falkvinge TEDxBucharest - Duration: 18:17. TEDx Talks 74,313 views. 18:17. Changing the world through swarm intelligence: Rick Falkvinge at TEDxOslo 2013 ...


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Firefighters were called to attend a house fire on the Isle of Skye.
The fire broke out within a property in Ardvasar shortly after 7pm this evening.
Firefighters from Broadford, Kyle of Lochalsh and Portree were called to the scene after the alarm was raised at 7.14pm.
Upon arrival, crews established the incident was caused by a piece of plastic catching fire, causing smoke to build within the property.
Crews left the scene a short time later.
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