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Mold can grow almost anywhere in Hamburg, Pennsylvania if it has the necessary nutrients, so you have to be very careful. Thankfully, with our several years of experience in the Hamburg, PA mold removal industry, you can count on us to handle your mold problems in a heartbeat. It is important for you to have the mold removed as quickly as possible, which is why we will not delay in arriving to your Hamburg office or home. Making certain the mold will not come back is another step we take. Call HEASC Mold Removal, which is a mold remediation company in Hamburg, today at 888-547-2290 if you want assistance with mold testing.
What Can Cause Mold Growth in Hamburg, PA?
When you have areas inside your home that are wet and nutrient-rich, you will likely face the problem of mold. You will discover mold growing behind the surface of your walls since the wood provides it with an excellent source of nutrients, and this also tends to be a damper area. As a result, if you have water standing in your basement from a recent storm, mold may be lurking. Mold may also feed off ceiling tiles that have become moist because of leaky pipes. Mold is also attracted to buildings that are situated in areas with increased humidity.
Can Mold Result in Health Issues in Hamburg, PA
Mold can lead to some pretty serious health problems in addition to the property damage it can cause. One of the scariest things about mold is that it can get trapped in your home or office's ventilation system and wreak havoc throughout the building. Respiratory issues are one of the biggest health conditions linked with mold. In some instances, this means something as minor as a cough or throat irritation, but it may also lead to asthma or even death. Since black mold can cause so many issues, it is important to have us perform a black mold removal before it is too late. It would also be an excellent idea to have a mold removal completed at least annually to ensure mold is not developing in your home.
You may be able to reduce your chances of hassling with mold inspection by being a little more attentive for damp areas in your Hamburg, PA house or office. Considering that you never know if mold is toxic or not, it needs to be treated as quickly as possible before it harms you or your property. Mold damage repairs are very pricey, and you also do not want to find out how sick mold can make you. Call our mold remediation staff at HEASC Mold Removal at this time for help with your black mold remediation requirements.
How do Emergency Mold Removal Procedures Work in Hamburg, PA?
During our years in the Hamburg, Pennsylvania mold removal industry, our staff at HEASC Mold Removal has seen the damage mold can cause. Spending a fortune on repairs and medical expenses are just two negative consequences mold can cause in the Hamburg, PA region. The problem with mold is that it can unleash its fury anytime during the day and any day of the week. Due to the fact that you might detect mold growth at any time of the day or any day of the week, we also offer emergency mold remediation solutions in Hamburg. If you are prepared to schedule a mold remediation in Hamburg today or if you have questions, do not hesitate to call us at 888-547-2290.
Hamburg, PA Mold Remediation
Our customers will all tell you about how pleased they were with our easy scheduling practices and prompt arrival. In addition, our customers will inform you that they were relieved to learn that we do not toss a bunch of hidden fees on top of our estimated prices. To help us locate the area where the mold is growing, we commence each mold removal process with a mold inspection. After that, we figure out the most effective treatment option by taking a sample of the space that has been impacted by the mold. When we begin the actual treatment, we are going to ensure that the mold is removed in the safest possible manner and that it will not be coming back. Several years ago, we decided to offer our mold removal solutions around the clock since we understand that mold growth is not something that only occurs between 9 and 5. The great thing about our emergency services is that you can have your peace of mind back for a cost that is still very affordable. We take a lot of satisfaction in being able to help with your removal needs in Hamburg, PA every hour of every day. Likewise, be sure to take a peek at a few other towns and cities for instance, Fort Dodge, IA mold removal to find out if this site offers services in your area.
Searching for something to destruct or someone to make seriously sick in Hamburg, PA are two of mold's favorite hobbies, which is an extremely scary thought. By paying attention to changes in the structure of your property or business as well as moist and dark areas, you can lower your odds of dealing with mold. HEASC Mold Removal would also be delighted to perform a yearly mold testing procedure for those of you who want to stay as safe as possible. Get in touch with our crew at 888-547-2290 today if you need help with mold removal or if you have any concerns. We also offer service to Sheffield, IA mold removal amid other cities and states around the country.


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Champion Window Company of Tri-Cities, LLC
Johnson City, TN 37615
Champion Window Company of Tri-Cities, LLC
Champion Windows. Superior Quality. Lifetime Warranty.
With over six decades of experience and expertise, Champion Windows and Home Exteriors is one of the nation's leading home improvement companies. Champion transforms homes with premium-quality products that are designed, built, installed, and guaranteed by Champion. Every product the company offers - from new windows and sunrooms, to siding and entry doors - is built right here in the USA, backed by industry-leading limited lifetime warranties, and comes recommended by more than 9 out of 10 recent Champion customers. ***Please use this link to schedule an appointment https://www.championwindow.com/book-now
Service Area
- Kingsport
- Johnson City
- Bristol
- Greeneville
- Abingdon
- Morristown
- Bristol
- Banner Elk
- Piney Flats
- Blountville
- Cumberland
- Cawood
- Baxter
- Evarts
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- Spruce Pine
- Blowing Rock
- Newport
- Pennington Gap
- Dandridge
- Mars Hill
- Erwin
- Cornettsville
- Boone
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- Totz
- Loyall
- Benham
- Lynch
- See All >
Services Offered
Additions & Remodeling
- Sunroom or Patio Enclosure Build
- Vinyl Siding Install
Areas of Expertise
- Replacement Windows
- Sunrooms and Patio Enclosures
- Siding
- Entry Doors
Quick Facts
Business Hours(Please call to confirm)
- Free Estimates
- Credit Cards Accepted
In Business Since: 1953
Memberships & Affiliations
- American Architectural Manufacturers Association (AAMA)
- Efficient Windows Collaborative (EWC)
State Licensing
Green Certifications
- National Fenestration Rating Council - www.nfrc.org
- Lead-Safe Certified-Firm (EPA)
- Top 500 Qualified Remodeler, 2018
- #3 on Qualified Remodeler Top 500 list
- Window & Door Top 100 Manufacturers, Window & Door, 2018
ScreeningHomeAdvisor Screened. View Details
HomeAdvisor allows Service Professionals to post information about themselves and their business on their profile. HomeAdvisor does not review or verify the information or representations set forth in those profiles, as they are self-reported by the Service Professional.
HomeAdvisor verifies state-level licensing where applicable - note: some states require local or county level licensing and you should verify whether or not your pro is properly licensed.
To find more licensing information for your state, visit our Licensing Requirements page.
Business Overview
How We Got Started
We started in this industry in 1953.
We describe our business as Well established
Champion Window Company of Tri-Cities, LLC
Replacement Windows5 photos45903819
Sunrooms3 photos45903819
Siding4 photos45903819

subset: commoncrawl


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In my opinion, a lot of these guys want to be scammed because it is an adventure, and these girls are going to make these guys feel great before they finally end things after getting a lot of money out of the dating in the first place.
Conclusion Guys, you are free to get scammed any time they want because there are plenty of Russian and Ukrainian online dating scammers out there who are ready to take their money and make life difficult.
Dear friends, Some of my readers asked what happened to and why this matrimonial agency is now called
My today's article is a reply to all these questions; additionally I will review...
#2: Does the woman's photo look too good to be true? According to Daily uk, 25% of online daters use Photoshop to improve their profile images.
Find the profiles that have the obvious pictures with supermodels and hot chicks in the profile. 🙂 A lot of people have actually seen these pictures before, and it is rare that anyone has concerns about the photoshoped pictures.
They want to make sure that you are going to be hooked, and they can make sure that it is easy for people to get attached.
The attachment is going to make it much easier for the woman to get whatever she wants, and she will love the way it feels when you are hooked.As Svetlana Mukha, a founder and leading matchmaker at diolli.com, mentioned in her interview, some men just want to become a scam victim (I have no idea why, it might be a topic for my next article…).So that's why I decided to help those men and give some advice how to get scammed by Ukrainian and Russian online dating fraud.They might want to if they are really slutty, but most guys are going to get a kiss at best. #5: Use online dating services with a very bad reputation Some online dating services have such a bad reputation that anyone looking for a real date would never go there, but that is the perfect place for you to go when you are looking for scammers or women who are not genuine.A unrealiable and unserious dating site is an easy place to scout because all the accounts look like they are fake and like too beautiful and perfect to be true (see my tip #2), but that is the perfect place to go when you wants to make sure that they are going to get scammed.Dear friends, There are dozens if not hundreds of Ukrainian and Russian online dating websites out there claiming to help Western men meet the partner they've been looking for. Dear friends, today I want to introduce you to an interesting International dating service, namely: Kates


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About 48% of adults in the US said Trump should be impeached, while 40% opposed it, according to a Reuters/Ipsos poll published March 8.
The answer could be significantly influenced by the clock.
Now that Pelosi is being widely quoted as coming out against the impeachment of Trump, Democrats are divided over her comments, meaning another such moment will be litigated in coming days.
Pelosi's approach could also provide cover to some of her members, including freshmen who were elected in November from "red-to-blue" districts where impeachment is politically fraught.
The Democratic-controlled House of Representatives could pass articles of impeachment and start the process tomorrow, but what next? They took an oath to defend the Constitution, and the Constitution is clear regarding what to do with a president who is alleged to have committed high crimes and misdemeanors. "While I don't exclude that possibility, I don't think we should put the country through impeachment without that amount evidence".
Tamping down impeachment talk also enables Pelosi to keep the spotlight on the Democratic agenda, she told lawmakers in a private meeting Monday night.
But House Speaker Nancy Pelosi, D-Calif., told The Washington Post that impeaching the president is "just not worth it". One of the things that makes an ill-considered gambit to remove Trump "just not worth it", in Pelosi's words, is the opportunity cost.
"We're working very hard to deliver on those things, and I think the speaker wants to make sure we stay focused on that", he said.
"I think he probably ought to be impeached because of the budget document he sent up to the Hill yesterday, but that's another story", Rep. John Yarmuth, D-Ky., chairman of the House Budget Committee, said on CNN. Several congressional committees have launched their own investigations.
Any attempt to impeach Donald Trump is doomed without public support, says Adam Schiff. Impeachments can be a useful vehicle for forcing a debate on how we expect government officials to conduct themselves in office and for changing our constitutional norms and practices.
How Healthcare Providers Can Reduce Insurance Claim Denials
And, it's important to account for the time and effort spent by administrative staff handling these denied claims. They also have the potential to adversely affect patients' opinions about the organization.
By taking impeachment of Mr Trump off the table, Dr Smith believes we're seeing the beginnings of how Democrats plan to campaign in 2020. The state-by-state contests to decide the Republican and Democratic presidential nominees begin February 3, with the Iowa caucuses. As she says unless there is something so compelling and overwhelming and bipartisan, they can't get two thirds of the Republican vote.
"We do not now have the evidence all sorted out", Nadler told ABC's This Week program on 3 March.
But Trump's lawyers and White House advisers would be well-advised not to take Pelosi's comment at face value. An impeachment can accomplish that result even if the impeached official in not removed.
Raskin added, "Timing is obviously going to be a subsidiary factor along with the character of the offenses that have been discovered".
Chabot offered some advice to his fellow Judiciary Committee members: "Move forward with great caution".
Hollow attacks by some in our party failed to scar the political beast as she fought her way back into power and nearly immediately proved her worth (again) when she didn't blink an eye as Trump threw his childish tantrum of shutting down the government over his vanity wall.
On Tuesday, Sanders said that she was "glad [Pelosi] sees that the rest of us see, that there's no reason, no cause for impeachment".
While Pelosi said she wasn't in favour of impeaching Trump, she maintained that he wasn't fit for the presidency.
Even one of the strongest proponents of impeachment, freshman Rep. Rashida Tlaib of MI, said Tuesday that she is "absolutely not" disappointed in Pelosi.
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Sao Paulo school shooting: 8 children and two adult killed in BrazilDoria said the school had been evacuated and police were inspecting what appeared to be possible explosives left by the shooters. The attack was carried out by two " armed and hooded " teenagers, according to police. "I heard a lot of screaming", she said.
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College Admissions Scam: Lori Loughlin Taken Into CustodyLaw enforcement sources reportedly informed NBC News that Loughlin is expected to appear in court Wednesday afternoon. Following her indictment on Tuesday, she was released on a $250,000 bond and was ordered to surrender her passport.
Aaron Hernandez's Murder Conviction Reinstated By MassUnder the new order, if a defendant passes before their appeal, the conviction stands without any affirmation or nullification. Hernandez's attorney had previously argued the legal doctrine should remain intact, saying juries make mistakes.


text:
Answer: Option D
Because bit arrays are compact, they outperform many other data structures.
Answer: Option D
Without compression, they become sparse in both time and space, also if random access is more common than sequential access, then they have to be compressed to byte/word array.
Answer: Option A
This is a non-generic way of creating an ArrayList.
Answer: Option C
The first part stores the items of the dynamic array and the second part is reserved for new allocations.
Answer: Option B
trace of a matrix is the sum of the principal diagonal elements.


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Youtube increase työt
MAIN QUALIFICATIONS: -Gung-...relevant and impressive 2 - You'll be receiving a small clip (3-5 mins) to edit and showcase your skills. Things to consider : 1 - If you're someone who understands the youtube gaming culture especially Fortnite in the US this will be much more convenient. 2 - This will be an ongoing project and not one-time editing.
We have a 40+ websites which works with similar script it use get data in website using YouTube API V3 now we need change it need to fatch data directly without YouTube API
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Simple one page app that I can post youtube videos on. Similar to a blog style website. Would need your help publishing the app on the app stores as well.
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i am making a YouTube video and would like a thumbnail
Our business is in Drone Aerial Photography Video Services. We are looking for cutting edge logo for our company "East2West " Need mix name company and drone pictures !!! Two colours, preferable yellow and black , bright, stylish elements and logo icon. Simple to use, maybe pantons for precise printing and publishing. Thank you in advance, and good luck!
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I'm a therapist looking for an expert
Please only apply if you have experience using premier pro and after effects. I need someone with experience to enhance our video experience. Must have experience in: Colour grading Adding text Creating smooth and complex transitions Remove objects and items from footage & Create and overall cinematic experience for 30-60s video that's going to be exciting & compelling for digital...
Mob app with a direct control of microphones and speakers works in background to affect other apps with the following features in single sliding screen: 1- One Text box to assign formula function of (x) of the inputs/microphone(s). 2- One Text box to assign formula function of (y) of the outputs/Speaker(s). 3- One Display shows (with both options of Spectrum / Oscilloscope) of all signals from eac...
...- website to accept donations News tab - the client will be posting news and all - need the latest news to be at the front page and rest all can be on the news tab. Link YouTube Channel, FB Other minor things here and there. Sample website: [kirjaudu nähdäksesi URL:n]
I need SEO specialist to create 50 clean high quality backlinks for a youtube channel ( video content).
...(at least for Sanskrit) and pronunciation very clear and also of Hindi VOA. The project will have many video volumes each of 30 slides and will be released every month on YouTube. We are collecting 1000+ such slokas and we have back-log of 3-4 such 30 min (30 slides) videos starting publication from September, The payment rate for VOA is $4/min of
Need a SEO to increase the traffic on my [kirjaudu nähdäksesi URL:n] is 20$.start with word 'time'
A new Real Estate company in Fairless Hills Pennsylvania. Buying and selling houses on terms. We are looking for someone with experience in FB ads and YouTube marketing ideas. Our Model Marketing-Leads-Deals-More Marketing-More leads-More deals. Our need: Promote and Maintain [removed by Freelancer.com].
...Raspberry Pi / Python world . I have a small project where I need to develop the same 4G bonding setup on my Raspberry PI but I need to stream to private video portal or to YouTube (private stream) A lot of the basic information is already laid out: [kirjaudu nähdäksesi URL:n] I'm hoping someone can quickly assist me in giving me a downloadable file
...currently editing the images of our rulers onto stock backgrounds with stock pics of people in the foreground. My photoshop editing qualification go as far as a handful of YouTube videos, and this shows. Again please take a look and let me know what you can do for me. Please feel free to be blunt. I will be getting pro photos taken of the rulers on white
I need my website re-configured.I need you to build it.
I need someone to edit video interviews into smaller bite-size pieces for social media- Facebook, Instagram and youtube. The right candidate should have some experience making shorter videos. The main purpose of these is to share with guests of interview so they can share with their followers as well. Please reply with the word "Badger" in title
I need help with an issue on my Jitsi server. I've changed the configuration of Jitsi + Jibri to send the live stream to a rt...Jitsi server. I've changed the configuration of Jitsi + Jibri to send the live stream to a rtmp server and it works fine, but when I'm on a live streaming and start sharing a youtube video my streaming drops after 10 minutes.
We have a PHP application that has a number of cron'd tasks that do work for our clients on a schedule. Tasks that download photos, upload videos to YouTube, etc. etc.. Right now, we have the task centered version of the application running on a single server, and the web interface running in Docker on Elastic Beanstalk. We want to create software defined
...goat farm. Presently we are keeping all data on excel sheet. We keep following data All goats have an identification tag with number 1. Monthly weight. If a goats weight increase by 1.5 kg and in mating register it was mated we take it as pregnant. 2. Mating register . When a goat is mated with a male one 3. Delivery register. A goat should be mated
Hi we need voice over artist , actress , reporter for our youtube channel
I want to hire a person for setting up my google adwords campaign for my YouTube videos
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I need a unique channel name for my technology channel in YouTube. It should be simple but catchy name for my YouTube channel. I'm looking for copyright free and unique name. So, don't waste your time posting internet copied entries. I prefer to include Tech in the name. If not Tech, it must be relevant to technology. Before posting your entry, make
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I want to make one YouTube introduction video. the video should be animated. This is for technical channel. This covers overall concepts of channel as well like share subscribe portion.
We're a new team of internet marketers who would like to cooperate with a professional eBay seller to manage our sales on long-term basis. This project is going to w...made on eBay and ability to grant immediate access to payments on PayPal. Note: We'll handle eBay's listing fee and PayPal's transfer fee. Your commission increases as sales increase.
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Comedy content for YouTube video, it should be a script in Hindi language filled with immense laughter. The play should contain 2 persons, Duration of the play should be around 20 mins
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Looking for someone to write highly engaging scripts for videos that are around 10 minutes long. These will be list posts or educational posts that are more fun and interesting topics
I Need someone who is good at Voice over for my youtube channel
We deal in women clothing on Instagram. We want someone for instagram marketing to increase the growth and sale of my page and products respectively.
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The video advert for YouTube. The Pace of the video will be need to be fast &trendy showing a variety of colourful vibrant Pakistani woman's clothing with pace music. At the same time we will need the following Points To be Highlight the following points. Free UK Delivery Signed For Buy Now Pay After 30 Days With Klarna Shahzadi Couture & MyClothingWarehouse
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text:
Bika: I don't want to chase Dirrell
By Scott Gilfoid: WBC super middleweight champion Sakio Bika (32-5-3, 21 KOs) seems to realize that he's going to be facing a much different Anthony Dirrell (26-0-1, 22 KOs) this Saturday night than the last one he faced last December at the Barclays Center in Brooklyn, New York.
In that fight, Dirrell fought pretty much the same way Floyd Mayweather Jr did in his last fight against Marcos Maidana by standing directly in front of him. Dirrell made it hard for himself by staying stationary against a fighter as rough and as tough as Bika with his physical style of fighting.
The outcome was a 12 round draw, and the only reason it ended in a draw was because Dirrell frequently beat Bika to the punch with his faster hands, and he landed the cleaner shots in the fight. Many of Bika's punches were rabbit shots with a few low blows mixed in. Dirrell plans on making it different this time by going out and boxing Bika this time, and not letting him have a stationary target.
"I'm not going to change too much. I'm coming out to fight," Bika said. "I don't want to run around and chase him. I'm going to show Anthony that I'm ready to do exactly what I've always done: to make people happy to see me fight. If he wants to take my belt off of me he better come prepared."
Bika is going to have to use his 35-year-old legs to try and cut off the ring in this fight because Dirrell is going to be using the entire ring this time. He's not going to make it easy for Bika this time. If you look at the guys that beat Bika in the past, Lucian Bute, Andre Ward and Joe Calzaghe, they all used movement against him to get the better of him.
For whatever reason, Dirrell chose not to follow their blueprint in his first fight with Bika, but you can bet that he's going to be following the blueprint on Saturday night. He knows how beat Bika and he knows the mistakes he made the last time he fought him. His brother Andre Dirrell has given him tips in how to out-box Bika and he's going to be following them to the letter in this fight to pick up the strap.
The winner of the Bika-Dirrell fight will likely be facing #4 WBC George Groves next because he's got an easy WBC title eliminator coming up on September 20th against Christopher Rebrasse and he should win that fight easily to get the title shot.
The Dirrell vs. Bika 2 fight will be taking place at the StubHub Center, in Carson, California, USA.
More Boxing News:
- Anthony Dirrell another option for Canelo Alvarez's next fight
- Yordenis Ugas – Mike Dallas FOX Weigh In Results & Photos
- Anthony Dirrell slams Canelo, says Kovalev 'took a DIVE'
- Statement From Nigel Benn
- WBC to order David Benavidez vs. Avni Yildirim next
- Ryan Garcia and Devin Haney must wait for Tank Davis clash says Mayweather Promoter
- Vasily Lomachenko reducing his purse to get Teofimo Lopez fight done
- Leo Santa Cruz can't afford to take shots from Gervonta Davis
- Eddie Hearn wants Tyson Fury vs. Deontay Wilder 3 cancelled if it's pushed back to February 2021
- Mike Tyson releases new training video for Roy Jones Jr match


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What you can do though is go to a store that sells 3ds eshop cards and buy one with your visa card.
It works, just go to the website on the back of the card, login and then enter your zip code.
Until you register it online you will only be able to use it in a store.
Can you use a debit card for Nintendo eShop?
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More wars followed, both to consolidate and to extend Asante conquests. During Osei Tutus reign as Asantehene (king of Asante), the area of Asante approximately ...
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Amerigo Vespucci was a merchant and explorer-navigator who took part in early voyages to the New World (1499-1500, 1501-02). The voyage of ...]]>
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Irans course of economic development foundered under Khomeinis rule, and his pursuit of victory in the Iran-Iraq War ultimately proved futile. Khomeini, however, was able ...


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When you have kids, especially boys, booboos happen – often. We have entirely too many first-aid kits on hand (if that's possible) so I'm confident that we can handle most occurrences right here at home. Luckily, we live quite close to our local hospital so, if all else fails, there's an entire medical staff nearby if ever needed. School, however, can be a bit of a concern for some parents. My little one's school, for example, does not have a nurse on staff making the teachers both the educators and booboo fixer-uppers. It is situations like this where every single teacher inside each and every classroom needs to be well prepared, just in case. That is where Teacher Peach comes in.
Teacher Peach is a wonderful little company that I happened upon not too long ago and, although I am not an employed educator, I absolutely love it. As parents we, much like school teachers, have needs and uses for very similar items to care for our children. Including everything from first-aid kits to greeting cards and writing utensils to tote bags, games, and activity kits, Teacher Peach surely has something to meet your needs and then some. I was recently given the opportunity to try out the new Teacher Peach Boo Boo Bag and I was quite pleased.
The Teacher Peach Boo Boo Bag is quite compact considering all that it has to offer. Fitting easily into a small zippered clutch, the bag contains the following:
- Bandages
- Tissues
- Instant Cold Compress
- Tweezers for Splinter Removal
- Disposable Thermometer
- Assorted Wipes, Creams & Ointments (burn cream, antibiotic ointment, alcohol cleansing wipes, etc.)
- ICE – In Case of Emergency Contact Card
- Miniature Notebook
- Stickers for Feeling Better
- Miniature Pencil
There are over fifty first-aid supplies stored in this cute neoprene case that even features an extremely handy carabiner clip on the end. While Teacher Peach is geared towards educators, the entire line is quite parent friendly.
"We created the Boo Boo Bag to help teachers, parents, and caregivers take quick and easy care of routine bumps, spills, and other typical mishaps." -Randi Brill, Founder of Teacher Peach
The Boo Boo Bag is, of course, perfect for inside the classroom but I can think of at least one hundred other places that it would be just as perfect for – in the diaper bag, in Mom's purse, attached to the stroller, in Dad's pocket, in a child's backpack, in the bathroom, at your child(ren)'s sporting events, packed in your suitcase, on the playground, etc., though my favorite would be in the car. I have always been the think-ahead type and we're rather well prepared for most instances. Our diaper bag, with a mini first-aid kit inside, is usually in the vehicle whenever we go out but, for the handful of times that we don't have it with us, storing the Teacher Peach Boo Boo Bag in the vehicle's glove box allows for constant added security.
No matter your profession or where you plan to use it, the Boo Boo Bag is a bargain for its price of just $17.95. The only thing that I would recommend including in the bag would be a pair of rubber gloves. The Teacher Peach Boo Boo Bag first-aid kit is so versatile and, since its focus is on our little ones, it is truly the perfect accessory or gift for parents, grandparents, babysitters, coaches, nurses, and yes, teachers. With a slew of other great products as well, make sure that you keep up with Teacher Peach through social media on their Facebook, Twitter, and Pinterest pages to remain up to date on the latest news, products, specials, and sales. With spring and warmer weather right around the corner, and the number of outdoor activities and injuries sure to rise, grab yourself your very own Teacher Preach Boo Boo Bag so that you, too, are prepared for all of life's little booboos – in and out of the classroom.
*Randi received the above product(s), free of charge, to facilitate this review. All opinions are those of reviewer only.


text: Tal Amitai-Lavi LandE scape CONTEMPORARY ART REVIEW I personally don't think it can, we have all lived different lives and all had different experiences. No one person will have experienced the same life. I think it can be disconnected from a direct experience, but subconsciously all of our experiences influence the creative process. All of my projects have originated from an experience; it could be a conversation or something I have walked past in the street. These experiences trigger thoughts, ideas and help me to inspire a project. While you have once highlighte the importance of naming your works — for example in Minutes, the number corresponds to how many minutes the body has been in the cremator — sometimes your images rejects an explicit explanatory strategy: they seem to be the tip of the iceberg of what you are really attempting to communicate. How does representation and a tendency towards abstraction on a semantic level find their balance in your work? I don't want the viewer to understand the work immediately. The viewer has to work for the answers, but the images aren't abstract, they are all recognizable. I want the viewers to visually enjoy the work at first but then to start the secondary process of considering what they are looking at. I use a range of titles to communicate to nudge the viewers in the right direction. If the photographs are more visually loaded, I tend to give the work a slightly abstract title. In this two- 37


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my son says this body wash is "crazy good" he cant wait to see what i get for him next, lol he loves this website!!, lol..he says this "cool charge body wash", gives him a feeling of "wake up" his exact words, lol... he definitely wants me to buy it for him in the future!
I usually don't like changing my body wash brand but this one was worth it. It lathers well in the shower and gives you a super clean feel. Also smells nice and the scent will stay all day. It also has great cleaning properties, tough on dirt but still gentle so your skin doesn't feel super dry, especially in the winter.
This smells so good and leaves your skin super soft would defiantly recommend this to my family and friends. Also the smell of it is so nice also would buy this in the future. Thank you.
AXE Adrenaline Cool Charge Body Wash smells nice, a bit strong than I'd like to. It does a good job. Not very sure about the packaging, the tube feels too soft when squeezing.
I love this stuff! I fell in love with the smell of it and together with the axe 2-in-1 style prep shampoo it made a great combination. It had a slight cooling sensation which was a great way to start my day. Overall a great addition. #gotitfree
its a good product and the smell is nice and leaves your skin smooth and would defintly recommand this product to my friends and family and the price seems good and would defintly buy this product
Not sure about this one. I get dry skin easily with most scented body washes, and this one wasn't an exception. Use at your own discretion. Smells nice though.
AXE Adrenaline Cool Charge Body Wash was given as a freebie to try through the product review club.
My boyfriend tested it out and we both agreed that it had some pros and cons. The pros were that it was very effective at cleaning and moisturizing at the same time. However, it had a major con and that was the smell. We both found that it was too strong. If the scent was reduced, we would purchase this product again. At this time, we would recommend the product only to those who are not bothered by strong scents.
Iced Mint + Ginger... Yes to the Iced Mint. No to the Ginger. I found the ginger smell overpowering and I did not like it at all. If this had been purely Iced Mint I think I would have a completely different review.
The body wash did it's job though, I came out clean and felt refreshed. But I don't think I would recommend this particular scent to anyone.
I continued to try this product, as I didn't want to waste the body wash. I'm really glad that I did! I actually really enjoyed the scent the more I used it, and loved the tingle that the iced mint left on the body.
I would definitely be interested in purchasing again. But the ginger smell could be reduced a bit as well.
AXE Adrenaline Cool charge body wash is an amazing feeling! It feels like a detox running all over your body and has a very fresh feel that's not too strong. AMAZING!!
These reviews are the subjective opinions of ChickAdvisor members and not of ChickAdvisor Inc.


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Scratcher Joined 5 years, 9 months ago United States
About me
I am very into the Visual Arts and animation. My sister is SnapThat, if you don't already know.
Animations coming soon on -SpoilerAlert-, my newer other account!
Make sure to ♥ & ★, and ☺!
What I'm working on
I am one of those people who works on really big projects and thinks of another idea. I forget and completely lose interest in all other projects. But let me know in the comments what YOU want!
Featured ProjectThe Morning
What I've been doing
Shared Projects (19)View all
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- lf the world were 100 people...? by ScarletAsh25888
- Jumper (Platformer) by Depicklator
- Scratron 1.0 by sunoise
- F i l l - blocks v1.30 by youkaiwatch
- ビルの窓ふき Window Cleaning by praplane
- Shufflepuck 100% Pen by ajzat25
- Walk around by SzBogi
- Scratch 101: Jumping and Smooth Gliding by acduckii_rises
- Slime Ninja by DarkLava
- First Kid on Mars by 4ggcV
- A Boy and His Light by thedotmaster
- Lathe (3d Editor) by MartinBraendli
- Amalgam by DualityReality
- CAT-APULT by FUZZIE-WEASEL
- Misadventures of Dobby [HP Cartoon #1] by Class12321
- Boxformer by SuperPixels
- Elf Run by PullJosh
- Dolphins 3D by heldlaw
- -BreadMan-'s Terraria Bosses by -BreadProjects-
- Color Wheel (a game) by Doctor_Llama
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Leveraged trading in foreign currency or off-exchange products on margin carries significant risk and may not be suitable for all investors. We advise you to carefully consider whether trading is appropriate for you based on your personal circumstances. Forex trading involves risk. Losses can exceed deposits. We recommend that you seek independent advice and ensure you fully understand the risks involved before trading.
Election year historical data is a good base for identifying the range of outcomes for this year as 2020 is an election year. The data below shows the historical data, which may be relevant to how 2020 might shape up. Given the many unknowns in 2020 (impeachment, trade war truce, economy and the outcome of the election itself), this year is especially ...


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Product information
The RFiD Waist Wallet Mini from Lifeventure is designed to keep all your important documents and cards safe while out exploring the world.
It is made from a lightweight, soft stretch fabric and features a fast wicking nylon fabric on the back panel to keep you comfortable in warmer climates. It has one large zipped RFiD protected pocket for storing boarding passes and passports and other important travel documents. The elasticated webbing belt includes slim-line buckles so you are able to wear the wallet discretely.
The wallet shields the contents from radio frequency identification (RFiD) readers by stopping the information being transmitted through the nickel and copper coated polyester fabric.
Product features
- RFiD protection
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- Slimline buckles
- Moisture wicking back panel
- Fits 26 to 40in waists
- Dimensions: 11 x 22cm
- Weight: 50g
- Delivery: Free on orders over £50, otherwise £4.95. Please take note of the delivery dates above for an estimated delivery timescale.
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Goodbye preschool… Have a nice summer! Some of us will see you again in September. All the classes had their final goodbye lunch this week. For the 4's class Ruby hosted us at her home and shared her beautiful home and friendly pets!
A play and learning based preschool located between Kerrisdale and Dunbar.


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Make social videos in an instant: use custom templates to tell the right story for your business.
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Chloé Vadot
october 2016
filmed during a permaculture workshop with joana torres (oficina) and alejandro chellet in rosendale, new york
video and production by chloé vadot


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text: The passage, "to Live, to Live, TO LIVE must be the unswerving resolve," occurring in the article on the Elixir of Life, published in the March and April Numbers of Vol. III of the Theosophist, is often quoted, by superficial readers unsympathetic with the Theosophical Society, as an argument that the above teaching, of occultism is the most concentrated form of selfishness. In order to determine whether the critics are right or wrong, the meaning of the word "selfishness" must first be ascertained. According to an established authority, selfishness is that "exclusive regard to one's own interest or happiness; that supreme self-love or self-preference which leads a person to direct his purposes to the advancement of his own interest, power, or happiness, without regarding those of others." In short, an absolutely selfish individual is one who cares for himself and none else, or, in other words, one who is […] Read More


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CIO Bulletin
An Indonesia-based startup, Eureka AI has recently announced that it has raised US$20 million in its Series B funding round. The event also saw the participation of companies like Apis Partners, Gobi Partners, the Riyad Taqnia Fund, and MEC Ventures.
Some of the other companies that participated in the round were SG Innovate, GDP Ventures, Pacific Bridge, and Cianna Capital. These are the companies that joined the list of existing investors including SoftBank, PPF Home, Credit, and East Ventures.
Eureka AI was established in 2017 and has developed an AI enterprise software platform called 'Spectrum' that organizes mobile data to deliver actionable intelligence at scale. Its products include audience, risk, mobility, market intelligence, and activation. It caters to industries like banking, insurance, transportation, fast-moving consumer goods, and telecommunications.
The startup plans to channelize the fresh funds into supporting its plans to expand in the international market of Europe and Asia along with further developments of its product portfolio.
On the fundraising round, managing partner at Apis, Udayan Goyal, said: "Mobile operators today face twin pressure from pricing pressure and rising costs, whilst facing a shortage of data scientists. By leveraging products on Eureka's platform, enterprise clients of mobile operators can offer more relevant and personalized services to their customers."
Singapore-based startup Insider raises $32 million in Series C
Veeam hires Habisanti as its Indonesian leader for cloud gains
OnePlus officially confirms the new cheaper series "Nord"
To create cybersecurity awareness, Vamnicom conducted a series of Webinars
Realme Narzo series to compete with Redmi, POCO
© 2020 CIO Bulletin. All rights reserved.
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Previous work led to the proposal that the precision feeding of a high-concentrate diet may represent a potential method with which to enhance feed efficiency (FE) when rearing dairy heifers. However, the physiological and metabolic mechanisms underlying this approach remain unclear. This study used metabolomics analysis to investigate the changes in plasma metabolites of heifers precision-fed diets containing a wide range of forage to concentrate ratios. Twenty-four half-sib Holstein heifers, with a similar body condition, were randomly assigned into four groups and precision fed with diets containing different proportions of concentrate (20%, 40%, 60% and 80% based on DM). After 28 days of feeding, blood samples were collected 6 h after morning feeding and gas chromatography time-of-flight/MS was used to analyze the plasma samples. Parameters of oxidative status were also determined in the plasma. The FE (after being corrected for gut fill) increased linearly (P < 0.01) with increasing level of dietary concentrate. Significant changes were identified for 38 different metabolites in the plasma of heifers fed different dietary forage to concentrate ratios. The main pathways showing alterations were clustered into those relating to carbohydrate and amino acid metabolism; all of which have been previously associated with FE changes in ruminants. Heifers fed with a high-concentrate diet had higher (P < 0.01) plasma total antioxidant capacity and superoxide dismutase but lower (P ≤ 0.02) hydroxyl radical and hydrogen peroxide than heifers fed with a low-concentrate diet, which might indicate a lower plasma oxidative status in the heifers fed a high-concentrate diet. Thus, heifers fed with a high-concentrate diet had higher FE and antioxidant capacity but a lower plasma oxidative status as well as changed carbohydrate and amino acid metabolism. Our findings provide a better understanding of how forage to concentrate ratios affect FE and metabolism in the precision-fed growing heifers.
In this paper, the generation of relativistic electron mirrors (REM) and the reflection of an ultra-short laser off the mirrors are discussed, applying two-dimension particle-in-cell simulations. REMs with ultra-high acceleration and expanding velocity can be produced from a solid nanofoil illuminated normally by an ultra-intense femtosecond laser pulse with a sharp rising edge. Chirped attosecond pulse can be produced through the reflection of a counter-propagating probe laser off the accelerating REM. In the electron moving frame, the plasma frequency of the REM keeps decreasing due to its rapid expansion. The laser frequency, on the contrary, keeps increasing due to the acceleration of REM and the relativistic Doppler shift from the lab frame to the electron moving frame. Within an ultra-short time interval, the two frequencies will be equal in the electron moving frame, which leads to the resonance between laser and REM. The reflected radiation near this interval and corresponding spectra will be amplified due to the resonance. Through adjusting the arriving time of the probe laser, a certain part of the reflected field could be selectively amplified or depressed, leading to the selective adjustment of the corresponding spectra.
The modelling of edge carbon transport and emission on EAST tokamak under resonant magnetic perturbation (RMP) fields has been conducted with the three-dimensional edge transport code EMC3-EIRENE. The measured vertical distribution of CVI emission by the extreme ultraviolet spectrometer system for the perturbed case shows a reduction in the CVI emission by 20 % compared to the equilibrium case. The chord-integrated CVI emission can be reconstructed by EMC3-EIRENE modelling, which presents an increase in the CVI emission with RMP fields. The discrepancy between experiments and simulations has been investigated by parameter study to examine the sensitivity of the simulation results on the edge plasma conditions and the impurity perpendicular transport. It is found that the variation of edge plasma conditions for the equilibrium case cannot resolve the discrepancy in the CVI emission between simulations and measurements. The simulations with enhanced impurity perpendicular transport coefficient allows a reasonable agreement with the measured reduction of CVI emission.
Reducing dietary CP content is an effective approach to reduce animal nitrogen excretion and save protein feed resources. However, it is not clear how reducing dietary CP content affects the nutrient digestion and absorption in the gut of ruminants, therefore it is difficult to accurately determine how much reduction in dietary CP content is appropriate. This study was conducted to investigate the effects of reduced dietary CP content on N balance, intestinal nutrient digestion and absorption, and rumen microbiota in growing goats. To determine N balance, 18 growing wether goats (25.0 ± 0.5 kg) were randomly assigned to one of three diets: 13.0% (control), 11.5% and 10.0% CP. Another 18 growing wether goats (25.0 ± 0.5 kg) were surgically fitted with ruminal, proximate duodenal, and terminal ileal fistulae and were randomly assigned to one of the three diets to investigate intestinal amino acid (AA) absorption and rumen microbiota. The results showed that fecal and urinary N excretion of goats fed diets containing 11.5% and 10.0% CP were lower than those of goats fed the control diet (P < 0.05). When compared with goats fed the control diet, N retention was decreased and apparent N digestibility in the entire gastrointestinal tract was increased in goats fed the 10% CP diet (P < 0.05). When compared with goats fed the control diet, the duodenal flow of lysine, tryptophan and phenylalanine was decreased in goats fed the 11.5% CP diet (P < 0.05) and that of lysine, methionine, tryptophan, phenylalanine, leucine, glutamic acid, tyrosine, essential AAs (EAAs) and total AAs (TAAs) was decreased in goats fed the 10.0% CP diet (P < 0.05). When compared with goats fed the control diet, the apparent absorption of TAAs in the small intestine was increased in goats fed the 11.5% CP diet (P < 0.05) and that of isoleucine, serine, cysteine, EAAs, non-essential AAs, and TAAs in the small intestine was increased in goats fed the 10.0% CP diet (P < 0.05). When compared with goats fed the control diet, the relative richness of Bacteroidetes and Fibrobacteres was increased and that of Proteobacteria and Synergistetes was decreased in the rumen of goats fed a diet with 10.0% CP. In conclusion, reducing dietary CP content reduced N excretion and increased nutrient utilization by improving rumen fermentation, enhancing nutrient digestion and absorption, and altering rumen microbiota in growing goats.
Se can enhance lactation performance by improving nutrient utilization and antioxidant status. However, sodium selenite (SS) can be reduced to non-absorbable elemental Se in the rumen, thereby reducing the intestinal availability of Se. The study investigated the impacts of SS and coated SS (CSS) supplementation on lactation performance, nutrient digestibility, ruminal fermentation and microbiota in dairy cows. Sixty multiparous Holstein dairy cows were blocked by parity, daily milk yield and days in milk and randomly assigned to five treatments: control, SS addition (0.3 mg Se/kg DM as SS addition) or CSS addition (0.1, 0.2 and 0.3 mg Se/kg DM as CSS addition for low CSS (LCSS), medium CSS (MCSS) and high CSS (HCSS), respectively). Experiment period was 110 days with 20 days of adaptation and 90 days of sample collection. Dry matter intake was higher for MCSS and HCSS compared with control. Yields of milk, milk fat and milk protein and feed efficiency were higher for MCSS and HCSS than for control, SS and LCSS. Digestibility of DM and organic matter was highest for CSS addition, followed by SS addition and then control. Digestibility of CP was higher for MCSS and HCSS than for control, SS and LCSS. Higher digestibility of ether extract, NDF and ADF was observed for SS or CSS addition. Ruminal pH decreased with dietary Se addition. Acetate to propionate ratio and ammonia N were lower, and total volatile fatty acids (VFAs) concentration was greater for SS, MCSS and HCSS than control. Ruminal H ion concentration was highest for MCSS and HCSS and lowest for control. Activities of cellobiase, carboxymethyl-cellulase, xylanase and protease and copies of total bacteria, fungi, Ruminococcus flavefaciens, Fibrobacter succinogenes and Ruminococcus amylophilus increased with SS or CSS addition. Activity of α-amylase, copies of protozoa, Ruminococcus albus and Butyrivibrio fibrisolvens and serum glucose, total protein, albumin and glutathione peroxidase were higher for SS, MCSS and HCSS than for control and LCSS. Dietary SS or CSS supplementation elevated blood Se concentration and total antioxidant capacity activity. The data implied that milk yield was elevated due to the increase in total tract nutrient digestibility, total VFA concentration and microorganism population with 0.2 or 0.3 mg Se/kg DM from CSS supplementation in dairy cows. Compared with SS, HCSS addition was more efficient in promoting lactation performance of dairy cows.
Childhood trauma is known to predispose to a variety of psychiatric disorders, including anxiety, mood, and substance use. However, the relationship between childhood trauma and obsessive-compulsive disorder (OCD) has not been well studied. The aim of the present study is to compare childhood trauma experience between OCD and controls, and explore its impact on symptoms of OCD.
One hundred eighty-five outpatients who met DSM-IV diagnosis of OCD and 132 gender- age- matched controls were included in this study. The Early Trauma Inventory Self Report-Short Form (ETISR-SF) was administered to all participants to evaluate 4 types (general, physical, emotional and sexual) of trauma and its severity. The Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) was used to measure the severity of symptoms of OCD patients.
OCD patients showed a significantly greater severity in all four types of trauma when compare with controls. 77% of OCD patients reported at least one type of childhood trauma experience, and 18% reported sexual trauma. Sexual trauma experience is significantly associated with obsessive but not compulsive symptoms of OCD patients. When compared to female OCD patients, male patients reported significantly higher scores on general trauma, physical abuse and emotional abuse; but lower of sexual abuse.
The present study revealed the high prevalence of childhood trauma among OCD patients, which is consistent with evidence from previous studies suggesting that childhood trauma may play a role in the development of mental disorders. It may be important to consider the impact of childhood trauma in OCD clinical management.
The treatment of refractory schizophrenia has been a clinical challenge for most psychiatrists. The possible mechanism of the refractory schizophrenia included diagnostic errors, medical conditions and brain dysgensis. Here, we described a patient with childhood-onset schizophrenia who had severe psychiatric symptoms such as auditory hallucination and persecutory delusion and so on. We reexamined all his possible medical conditions and found the patient had an abnormal enlarged Cavus Septum Pellucidum (CSP) combined with Cavum Vergae (CV) (maximum length>30 mm). Some reports suggested that abnormal CSP(length>6 mm) has an significant association with schizophrenia. However, abnormally large CSP or CSP/CV and related prognosis were reported rarely. This case suggested that abnormally enlarged CSP or CSP/CV may lead to schizophrenia and worse prognosis.
Depression and anxiety disorders are prevalent mental disorders in China. But some those patients do not seek help from psychiatrists firstly but see internists first.
This study aimed to investigate the prevalence of depressive - anxiety disorders in gastroenterology outpatients and assess the detection rate provided by physicians in China.
A multicenter, hospital-based cross-sectional study was carried on in the 15 large general hospitals of five cities cross China. A total of 1995 gastroenterological outpatients were screened by Hospital Anxiety and Depression Scale (HADS). Subjects whose HADS scores ≥ 8 were interviewed by psychiatrists, using Mini International Neuropsychiatric Interview (M.I.N.I) to make further diagnoses. Physicians' diagnoses and treatment were recorded.
The adjusted prevalence of depressive disorder and anxiety disorders was 14.39% and 9.42% respectively.
The prevalence of depressive-anxiety disorder is high in gastroenterology outpatients in China, which suggests the related training of detecting these mental disorders is needed to gastroenterologists.
Multiple neurotrophic factors, including vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF)-2, nerve growth factor (NGF) and insulin-like growth factor(IGF)-1, have been shown to play important roles in the pathophysiology of mood disorders. However, insufficient clinical data supporting the importance of these neurotrophic factors in mood disorders, especially manic episode, have made inconclusive to make a connection between these factors and the disorder.
This study intended to investigate possible peripheral biomarkers in serum of manic episode of bipolar disorder.
We aimed to investigate whether or not serum levels of VEGF, FGF-2, NGF and IGF-1 varied in manic state.
Serum levels of VEGF, FGF-2, NGF and IGF-1 were examined in 70 drug-naïve patients with manic episode of bipolar disorder (BM) as well as 50 healthy controls, using an ELISA method.
The mean serum levels of VEGF, FGF-2, NGF and IGF-1 were 168.13±225.61pg/ml, 279.09±378.62pg/ml, 61.38±171.67pg/ml and 162.01±72.00ng/ml in BM patients, and 140.80±143.71pg/ml, 275.46±235.29pg/ml, 36.34±15.14pg/ml and 138.90±80.11ng/ml in healthy controls, respectively. Serum levels of FGF-2, NGF and IGF-1 in patients were significantly higher than those in healthy controls (Z=−2.896, P=0.004; Z=− 2.050, P=0.040; Z=−2.188, P=0.029; respectively), although there was no statistical difference in the serum levels of VEGF between two groups (Z=-0.468, P=0.639). Moreover, serum levels of NGF in patients correlated with the duration of disorder (rs=−0.241, P=0.044).
The increase in serum levels of FGF-2, NGF and IGF-1 in manic state may reflect a neuroprotective role for these factors, and these factors may be considered biological markers for manic episode.
Studies revealed that prenatal stress (PS) may increase the vulnerability to depression in their offspring, and ERK-CREB signal system might play a role in its mechanism.
The present study investigated the effect of MK-801 on depressive-like behavior and its impacts on ERK2, CREB, Bcl-2 mRNA expression in PS female rat offspring.
The pregnant rats were randomly divided into three groups, the control group (Con) was left undisturbed, the PS-saline group (PS-saline) and the PS-MK-801 group (PS-MK-801) were subjected to restraint stress on days 14–20 of pregnancy three times daily for 45 min, and received an i.p. administration of saline or MK-801(sigma, 0.2 mg/kg) 30 min before the first stress respectively. Forced swimming test was undertaken to assess depressive-like behavior in one month female offspring. ERK2, CREB, Bcl-2 mRNA in the hippocampus, frontal cortex, and striatum were detected by RT-PCR.
PS-saline spent significantly more immobile time compared to Con and PS-MK-801 (P < 0.05). ERK2 and CREB mRNA expression in hippocampus and frontal cortex was significantly decreased in PS-saline compared to Con and PS-MK-801 (P < 0.05), while in striatum CREB mRNA expression in PS-saline was lower than Con (P < 0.05). Bcl-2 mRNA expression in hippocampus and striatum was significantly decreased in PS-saline (P < 0.05), and in frontal cortex, its expression was significantly lower in PS-saline and PS-MK-801 (P < 0.05).
PS may suppress ERK-CREB signal pathway in female offspring rats, which could be partly prevented by MK- 801. (Supported by National Natural Science Foundation of China, No: 30970952).
The aim of this study is to explore the different patterns of self-management among people with schizophrenia, in order to help professionals provide more effective support tailored to different characteristics and needs of clients.
Totally 214 clients with schizophrenia living in 8 communities of Beijing, China were assessed, using Chinese version of Schizophrenia Self-Management Instrument Scale (SSMIS). Cluster analysis was performed to categorize clients based on their scores in 6 self-management areas.
K-means cluster analysis revealed four different self-management patterns. 'Self-confident and Autonomous' (n=63), clients actively participated in self-management and had a certain skills. 'Overconfident' (n=94), these clients had high self-efficacy and did well in medication compliance, while not in other areas. In their eyes, this was enough and they were experienced enough. 'Passive and Compliant' (n=51), clients often relied on their caregivers to manage the disease, yet did worse either in dimensions of symptom management or using health resource and support. 'No involvement' (n=6), clients' self-efficacy was low. They rarely participated in self-management and did worse in every self-management areas. Four pattern clients had significant differences in educational level, work status and financial burden (P<0.05).
There are subgroups of schizophrenic people with unique multidimensional patterns of self-management behaviors. This may help health professionals provide more customized support to improve clients' health status.
Studies have convinced that the rodents' exposure to prenatal stress (PNS) may induce depression and anxiety to their offspring. We focused on the glutamatergic system to explore the mechanisms.
By examining EAAT2,EAAT3 (Excitatory Amino Acid Transporter 2,3), which are the only substances to inactivate glutamate in nervous system, we explored the effect of PNS on glutamatergic system.
Pregnant rats were assigned to Control group (CON), Middle period of PNS group (MPS) and Late period of PNS group (LPS). MPS and LPS rats were exposed to restraint stress on days 7–13, 14–20 of pregnancy three times daily for 45 min. EAAT2 and EAAT3 mRNA expression in the hippocampus, frontal cortex, and striatum of one month rat offspring were checked by RT-PCR.
For the female offspring, EAAT2 mRNA expression of hippocampus in LPS and MPS was significantly lower compared to CON(P = 0.008,p = 0.003); EAAT2 and EAAT3 mRNA expression of frontal cortex in LPS were significantly lower than CON (p = 0.003,p = 0.013). for the male offspring, EAAT2 and EAAT3 mRNA expression of hippocampus in LPS and MPS were significantly lower (p = 0.005, p = 0.05); EAAT2 mRNA expression of frontal cortex was significantly lower in LPS (p = 0.022); EAAT2 mRNA in LPS group and MPS were significantly lower (p = 0.009, p = 0.014), and EAAT3 mRNA expression of striatum in MPS was significantly lower (p = 0.049).
Decreased EAAT2 and EAAT3 of PNS may explain the increase of glutamate in synaptic cleft and its downstream excitotoxicity. (Supported by National Natural Science Foundation of China, No: 30970952)
Brain-derived neurotrophic factor (BDNF) has an important role in learning, motivation and regulation of mood. A body of research indicates that dysregulation of BDNF is found in post-traumatic stress disorder (PTSD). The aim of this study was to investigate the association of baseline plasma BDNF and follow-up PTSD symptoms in Chinese motor vehicle accident survivors.
Motor vehicle accident (MVA) survivors were recruited from one Emergency Room of Shanghai. BDNF plasma levels were measured in 24 hours after motor vehicle accident. The Clinician-Administered PTSD Scale (CAPS) was used to evaluated PTSD symptoms one month after accident. Totally, 60 MVA survivors participated in this study and 49 of them completed follow-up evaluation.
In the one month follow-up interview, 14 of the MVA survivors met the PTSD diagnosis. The PTSD MVA survivors shown lower baseline BDNF plasma level when compare with non-PTSD participants (p < 0.05).
People who show lower plasma BDNF after traumatic event may be more susceptible to PTSD, and plasma BDNF could be a predictor of PTSD.
Epidemiological studies have convinced that prenatal stress (PS) might cause offspring depression.
Our pervious research work certified that PS can increases the glutamate level of hippocampus of rat offspring, which inspired us to explore the pathogenesis of depression by focusing on glutamatergic system.
Pregnant rats were randomly assigned to control group (CON), mid prenatal stress group (MPS) and late prenatal stress group (LPS). The pregnant rats of MPS and LPS were exposed to restraint stress on days 7–13, 14–20 of pregnancy three times for 45 min respectively. Tail suspension test (TST) was performed to examine the depression like behavior and Western-blot were used to test phosphorylated GluR1(pGluR1) of AMPAR expression in the hippocampus, striatum and frontal cortex of one month rat offspring.
For both male and female offspring, the time of immobility of TST in LPS (156±11, 155±12) and MPS (173±15, 155±12) was significantly longer (P< 0.05) than CON(118±8,113±12), the latency in MPS (18±3, 24±3) was significantly shorter (P< 0.05) than CON (30±5, 58±11). The pGluR1 expression in hippocampus and frontal cortex in LPS (1.77±0.45, 1.00±0.09) and MPS (1.65±0.51, 1.05±0.18) were significantly lower (P< 0.05) than CON (3.72±0.86, 2.05±0.34) in male rat offspring.
It is suggested that the PS may induce depression like behavior in rat offspring, and glutamate receptors subunit pGluR1 might be involved in the etiology of depression.
(The research is supported by National Natural Science Foundation of China, No: 30970952, 18110059).
Current available antidepressants exhibit low remission rate with a long response lag time. Growing evidence has demonstrated acute sub-anesthetic dose of ketamine exerts rapid, robust, and lasting antidepressant effects. However, a long term use of ketamine tends to elicit its adverse reactions. The present study aimed to investigate the antidepressant-like effects of intermittent and consecutive administrations of ketamine on chronic unpredictable mild stress (CUMS) rats, and to determine whether ketamine can redeem the time lag for treatment response of classic antidepressants. The behavioral responses were assessed by the sucrose preference test, forced swimming test, and open field test. In the first stage of experiments, all the four treatment regimens of ketamine (10 mg/kg ip, once daily for 3 or 7 consecutive days, or once every 7 or 3 days, in a total 21 days) showed robust antidepressant-like effects, with no significant influence on locomotor activity and stereotype behavior in the CUMS rats. The intermittent administration regimens produced longer antidepressant-like effects than the consecutive administration regimens and the administration every 7 days presented similar antidepressant-like effects with less administration times compared with the administration every 3 days. In the second stage of experiments, the combination of ketamine (10 mg/kg ip, once every 7 days) and citalopram (20 mg/kg po, once daily) for 21 days caused more rapid and sustained antidepressant-like effects than citalopram administered alone. In summary, repeated sub-anesthestic doses of ketamine can redeem the time lag for the antidepressant-like effects of citalopram, suggesting the combination of ketamine and classic antidepressants is a promising regimen for depression with quick onset time and stable and lasting effects.
The aim of this study was to develop and externally validate a simple-to-use nomogram for predicting the survival of hospitalised human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) patients (hospitalised person living with HIV/AIDS (PLWHAs)). Hospitalised PLWHAs (n = 3724) between January 2012 and December 2014 were enrolled in the training cohort. HIV-infected inpatients (n = 1987) admitted in 2015 were included as the external-validation cohort. The least absolute shrinkage and selection operator method was used to perform data dimension reduction and select the optimal predictors. The nomogram incorporated 11 independent predictors, including occupation, antiretroviral therapy, pneumonia, tuberculosis, Talaromyces marneffei, hypertension, septicemia, anaemia, respiratory failure, hypoproteinemia and electrolyte disturbances. The Likelihood χ2 statistic of the model was 516.30 (P = 0.000). Integrated Brier Score was 0.076 and Brier scores of the nomogram at the 10-day and 20-day time points were 0.046 and 0.071, respectively. The area under the curves for receiver operating characteristic were 0.819 and 0.828, and precision-recall curves were 0.242 and 0.378 at two time points. Calibration plots and decision curve analysis in the two sets showed good performance and a high net benefit of nomogram. In conclusion, the nomogram developed in the current study has relatively high calibration and is clinically useful. It provides a convenient and useful tool for timely clinical decision-making and the risk management of hospitalised PLWHAs.
Combining different swine populations in genomic prediction can be an important tool, leading to an increased accuracy of genomic prediction using single nucleotide polymorphism (SNP) chip data compared with within-population genomic. However, the expected higher accuracy of multi-population genomic prediction has not been realized. This may be due to an inconsistent linkage disequilibrium (LD) between SNPs and quantitative trait loci (QTL) across populations, and the weak genetic relationships across populations. In this study, we determined the impact of different genomic relationship matrices, SNP density and pre-selected variants on prediction accuracy using a combined Yorkshire pig population. Our objective was to provide useful strategies for improving the accuracy of genomic prediction within a combined population. Results showed that the accuracy of genomic best linear unbiased prediction (GBLUP) using imputed whole-genome sequencing (WGS) data in the combined population was always higher than that within populations. Furthermore, the use of imputed WGS data always resulted in a higher accuracy of GBLUP than the use of 80K chip data for the combined population. Additionally, the accuracy of GBLUP with a non-linear genomic relationship matrix was markedly increased (0.87% to 15.17% for 80K chip data, and 0.43% to 4.01% for imputed WGS data) compared with that obtained with a linear genomic relationship matrix, except for the prediction of XD population in the combined population using imputed WGS data. More importantly, the application of pre-selected variants based on fixation index (Fst) scores improved the accuracy of multi-population genomic prediction, especially for 80K chip data. For BLUP|GA (BLUP approach given the genetic architecture), the use of a linear method with an appropriate weight to build a weight-relatedness matrix led to a higher prediction accuracy compared with the use of only pre-selected SNPs for genomic evaluations, especially for the total number of piglets born. However, for the non-linear method, BLUP|GA showed only a small increase or even a decrease in prediction accuracy compared with the use of only pre-selected SNPs. Overall, the best genomic evaluation strategy for reproduction-related traits for a combined population was found to be GBLUP performed with a non-linear genomic relationship matrix using variants pre-selected from the 80K chip data based on Fst scores.
The catechol-O-methyltransferase (COMT) gene is related to dopamine degradation and has been suggested to be involved in the pathogenesis of major depressive disorder (MDD). However, how this gene affects brain function properties in MDD is still unclear.
Fifty patients with MDD and 35 cognitively normal participants underwent a resting-state functional magnetic resonance imaging scan. A voxelwise and data-drive global functional connectivity density (gFCD) analysis was used to investigate the main effects and the interactions of disease states and COMT rs4680 gene polymorphism on brain function.
We found significant group differences of the gFCD in bilateral fusiform area (FFA), post-central and pre-central cortex, left superior temporal gyrus (STG), rectal and superior temporal gyrus and right ventrolateral prefrontal cortex (vlPFC); abnormal gFCDs in left STG were positively correlated with severity of depression in MDD group. Significant disease × COMT interaction effects were found in the bilateral calcarine gyrus, right vlPFC, hippocampus and thalamus, and left SFG and FFA. Further post-hoc tests showed a nonlinear modulation effect of COMT on gFCD in the development of MDD. Interestingly, an inverted U-shaped modulation was found in the prefrontal cortex (control system) but U-shaped modulations were found in the hippocampus, thalamus and occipital cortex (processing system).
Our study demonstrated nonlinear modulation of the interaction between COMT and depression on brain function. These findings expand our understanding of the COMT effect underlying the pathophysiology of MDD.
The cerebral blood flow (CBF) is an absolute measure that superior to the relative measure of neural activity, blood oxygenation-level-dependent (BOLD). The previous studies have reported CBF abnormalities in the adult depressive patients. However, it is not clear whether the abnormal CBF could be improved in the remitted geriatric depression (RGD).
We enrolled 82 RGD patients and 90 age and education matched healthy controls. All the subjects underwent 3-T MRI with pseudo arterial spin labeling (pASL), and the pASL data were analysis voxel-by-voxel with control the gray matter volume.
Compared with the healthy controls, the RGD patients demonstrated higher relative CBF value in left inferior temporal gyrus and left precuneus; while lower relative CBF value in right medial temporal and occipital cortex, right insula operculum (including parts of frontal, temporal and parietal cortex) and insula, right medial frontal cortex. When compared with the remitted early onset depression (EOD), the remitted late onset depression (LOD) showed lowed relative CBF value in right angular gyrus. While there was no significantly different relative CBF value between the RGD patients accompany with MCI and RGD patients with cognitive normal.
The late life depression persists with CBF abnormalities in the remitted state. And it is implicit that hyperperfusion in the left brain cortex and hypoperfusion in the right brain cortex could be the specific form to RGD patients.
The authors have not supplied their declaration of competing interest.
Depression is a common psychiatric disorder affecting many people globally, and the worst outcome is suicide. But its neurobiology is hardly understood.
To use DTI to characterize abnormalities of white matter (WM) integrity in major depressive disorder patients with suicide attempts or suicidal ideation.
Present study aimed to give a more complete profile for the association of cerebral WM abnormalities with suicidal behavior in major depressive disorder patients by quantifying the suicidal ideation and behavior severity.
Thirteen depressive patients with suicide attempts (SA), 14 depressive patients with suicidal ideation but no suicide attempts (SI), 13 depressive patients without suicidal ideation or suicide attempts (NSD) and 40 healthy controls (HC) received MRI scans on a 3 T magnet. Whole brain voxel-based analysis of FA based on DTI was performed among the four groups using a threshold of P < 0.05 with FWE correction. FA values were extracted by Marsbar software to quantify the changes.
The four groups had significant differences of FA in the in the left splenium of corpus callosum (peak Z = 5.36 at −14, −36, 22). Quantify comparison revealed that SA had significant decreased FA value than SI, NSD, and HC. There was no significant difference among the other three groups, although there was a trend that SI and NSD had lower FA values than HC in this region.
Depression and suicide are associated with microstructure abnormalities of the white matter and patients with suicide attempts may have severe cerebral alteration.
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