text:
OnProcess Named in Gartner Report,
Cool Vendors in Supply Chain Services, 2016
"Digital business will force aftermarket services to transform. Profitably supporting digital business growth requires elastic and scalable aftermarket services that capture data across the
value chain, analyze it and determine an optimal course of action"
---"Cool Vendors in Supply Chain Services, 2016", Gartner Inc., 12 April 2016
Read Gartner's assessment of developments in Supply Chain Services, including a profile of OnProcess Technology.
To access the report from Gartner, complete the form to the right.
Disclaimer: Gartner does not endorse any vendor, product or service depicted in its research publications, and does not advise technology users to select only those vendors with the highest ratings or other designation. Gartner research publications consist of the opinions of Gartner's research organization and should not be construed as statements of fact. Gartner disclaims all warranties, expressed or implied, with respect to this research, including any warranties of merchantability or fitness for a particular purpose.
The Gartner Cool Vendor Logo is a trademark and service mark of Gartner, Inc., and/or its affiliates, and is used herein with permission. All rights reserved.


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I am a degree qualified mechanical engineer with a background in Precision Engineering and Automotive Manufacturing.
Since winning the British Engineering Design Council award for Engineering design in 1986 and coming runner-up in Young Engineers for Britain, I spent a decade working for two of Germany's leading car manufacturers until deciding to start my own heating business.
Having worked with experienced heating engineers for over 6 years, I gained invaluable experience of working on older as well as new systems while obtaining the latest qualifications at cutting edge training centres.
Continuous improvement is a fundamental part of my philosophy, so I keep my finger on the pulse of the latest technological and methodical advances by visiting the most important trade fairs including PHEX, Ecobuild and ISH (the word's largest heating exhibition in Frankfurt).
I have been using CGAs (Combustion Gas Analysers) since 2009 - more than two years before this became mandatory . CGAs can quickly and precisely highlight a dangerous situation, which traditional methods could normally not pick up. They are also an extremely accurate measuring device for air and gas pressures, temperatures and gas ratios.
At Hanover Heating we pride ourselves in combining a fastidious no-compromise approach with a cutomer orientated service at the best price possible. Our aim is to provide reliable, efficient and cost effective heating systems.
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subset: commoncrawl


text:
I had ridden the Dragon Ride before and I knew it was hard. I knew that I didn't need to do it again, I could say; "oh yeah, I've slayed the Dragon'.
So why was I queuing on the M4 waiting to get in to Margam Country Park for another beating from the Welsh dragon? Simple; this year it was different. 2012 saw it become the first ever British UCI Golden Bike event. I had to see what the increased hype was about.
I was pleasantly surprised that the format, route and start venue had all changed, and all for the better. After the numerous complaints from previous years of waiting hours in holding pens at the start, parking miles away and changing routes, this year there was nothing but nervous smiles at the start.
Riders tackle the mountainous climbs of South Wales
It was now efficient and effective from when you drove in to the stately park of Margam. Heading past the home which has been inhabited for the previous 4,000 years you got a real sense that you were coming to an event that held rank on an international stage.
The village and start/finish area was encompassed in the 850 acre estate. The festival type village was a great place to wander, have a quick pick-me-up coffee, and grab any last supplies before heading to the start area.
Pens were let off in regular intervals with ease causing no congestion on the roads. It was fast and the groups flowed as they headed out through the towns where there was partial road closures to ensure we all got through without delay. Although the constant on-off-on-off of my rain cape meant that there were a few stops early on, but luckily it chose to go, and my cape was stashed in my jersey pocket once and for all.
Wales offers up many views
Then the dreaded leg zapping hills started, and with a vengeance. Luckily there was support along the route, a testament to the new organisation having let the residents know of the event and encourage them out to see us go by. Gone was the easy coastal section of previous years meaning we all hit the famous climbs of Cimla, Rhigos and Bwlch with well warmed legs.
Uniquely the feed stations were stocked with huge bags of boiled potatoes and salt, a welcome surprise for many. Having to wait in an orderly queue to get to the delights of the feed station just added to the British feel of the event. Spotting the international athletes at these were no problem, they were the ones that went straight to the front pushed in, filled their bottles and their pockets, then rode on.
Even the odd hair-pin turn
Many of BSkyB's employees were out in their new kit giving everything a test before the Etape du Tour in four weeks time. The Dragon Ride is a great event to test out your kit, nutritional strategy, race day nerves and fitness before a big test in the European mountains.
The Grand Fondo totals 206 kilometres with 3,350 meters of climbing, meaning if you can get through this day then the Etape du Tour is achievable.
Coming up the deep green valleys of Rhigos and Bwlch the opposite way to 2011 meant I was pleasantly surprised to be at the top in good time. Seeing the coloured dots riding up in front meant that you could either think of seeing the way ahead as encouragement, or, if you are having a bad day, a constant reminder of what was to come.
Whipping down the other side gave great satisfaction and although the descents aren't as long as in Europe, they still give a fantastic feeling of free speed and adrenaline.
The mixture of road surfaces demands concentration
Pleased to not be heading off to take in the climbs of The Black Mountain and the "Hill With No Name" in the Brecon Beacons I continued on the Medio. Ducking in to the Breacon Beacons and doing the full route would have been the finish of me. This year's route was only seven kilometers longer than last year but with 700 meters more climbing. The Medio still packed a punch.
On the top of Bwlch I started a new phenomenon of banana wrapped in Soreen, which went down a mushy treat. The man handing out the banana's was swamped and told me that it was 'all down hill from here'. That old chestnut I had heard before.
What I hadn't heard before was riders pulling in to a feed station gasping for 'calories'. The course design this year was so demanding that it was beyond wanting a cake or a boiled potato, it was all about bare animal instincts of calories in to combat the demands on the body.
Gleefully it was actually all down hill to the finish, so I apologise to the banana man who I berated for lying to me. We zipped back along the coast where the course used to head out. It was a bit of a drag in to the country park again, but with those miles in your legs it will always feel that way.
The band and superb food at the finish meant we all hung out in the late afternoon sun sharing war stories. If I was travelling from abroad to this event, as I do to other Golden Bike events, I would be suitably impressed with the organization and how the route showcased the country.
Sportive sound bites
Name: Holly Barker
Age: 34
Lives: Brixton
"After completing the shorter route in 2011 I was a little nervous about how hard the long route would be. The first 50km was a little tough due to on and off rain but once that had passed the rest of the ride was really enjoyable.
I was riding with a couple of people who weren't aware of the profile and thought we had climbed the last hill when we reached the top of Rhigos. A quick stretch, another banana and some consoling words that the Bwlch was 'not that hard' and we pushed on.
Waiting at the bottom I had a lovely chat with a local boy who was about 7 and said I had a funny accent. He then very seriously said that he supposed he would have an accent too if he left Wales. It was a great feeling to arrive back at the country park having completed one my hardest rides for 2012."
Name: Ceri Ruzzi
Lives: London
"The Dragon Ride was the best cycle event I have done in the UK, friendly riders happy to encourage you up the hills and almost traffic free roads. The food station before the final climb was positioned at a great viewpoint to see the beautiful Welsh mountains. Will be back next year."
Next year's event
Keen to take part in 2013? Don't delay; entries will be opening on November 1 2012 at 9am. Set your reminders and be online in time as last year sold out in two and a half hours.
Now that it will be in it's second year and the course is staying the same, tough, we predict it to be the event to be at in 2013. Race organisers have taken on board the feedback survey and will be investing in the event to ensure every athlete has a world class unforgettable day.
If you would like to ride for charity the event is affiliated with The Prostate Cancer Charity and have packs on line to use for fundraising.
>> Struggling to get to the shops? Try 6 issues of Cycling Weekly magazine for just £6 delivered to your door <<
- Gran Fondo 206km/3350m
- Medio Fondo 125km/1875m
- Corto 37km/430m
Videos of the climbs can be found on-line so you can familiarise yourself with them.
Contact: www.wiggledragonride.com
The Dragon requires an industrious approach
Offical sanction
The UCI recognises the amateur cyclist and wants to provide Golden Ambassadors to the sport to provide events for all cyclists to enjoy. In 2012 these were the rides the UCI accredited to the Golden Bike series.
- Tour of Flanders (Belgium) 01 April 2012
- Wiggle Dragon Ride (Wales) 10 June 2012
- Quebrantahuesos (Spain) 23 June 2012
- L'Ariégeoise (France) 30 June 2012
- Lapinarello Cycling Marathon (Italy) 15 July 2012
- Lake Taupo Cycle Challenge (New Zealand) 24 November 2012
- www.ucigoldenbike.com
This article was first published in the September 27 issue of Cycling Weekly. You can also read our magazines on Zinio and download from the Apple store.


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Main Street waterfalls
Waratah Falls is a remarkable touch of nature uniquely located in the middle of town. Over 100 years ago water races and tunnels fed water to the falls. It then diverted to a nearby power station to produce hydro power. Today the falls provide a picturesque view for picnickers and photographers from Kings Park.


text:
It Was Tough For Us, Says Coach
After two days of competition, Navua have bowed out after losing one and drawing two in the Vodafone Muslim Interdistrict Championship at Ratu Cakobau Park, Nausori yesterday.
Navua drew 1-0 Nadi, lost 1-0 to Maigania and drew 1-1 with Ba. Coach Nasir Hussein said despite not qualifying for the quarterfinals, they are more focused on developing their young players.
"The competition has been very tough for us and we got a tough pool as well so the boys played the best they could," Hussein said.
"We have a very young side, we only have three or four players who are experienced but the rest of the players are still in high school and the first time for some of them to play in a competition.
"We didn't come here with high expectations, we knew we had a tough pool and we are focused on each game as much as we could."
Hussein said winning is not everything and their main focus was to expose their players.
Edited by Leone Cabenatabua
Feedback: email@example.com


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hg bookmark MARK to activate
clarify previous addition
|Deletions are marked like this.
|Additions are marked like this.
|Line 60:
|Line 60:
|* Make `hg bookmark MARK` activate MARK if it points to a working dir parent.
|* Make `hg bookmark MARK` activate MARK if it points to a working dir parent, without requiring --force.
This page is primarily intended for Mercurial's developers.
Bookmarks Plan
This is a DRAFT for discussion, and does not represent any firm decisions on future behavior.
Original draft by KevinBullock.
A plan to smooth out the usage of bookmarks as short-lived branches (a.k.a. feature branches). This covers several facets of bookmarks that have been discussed recently (June 2012) on the mailing list:
- Providing a default-update-on-clone bookmark (the '@' bookmark)
- Introducing bookmarks (particularly as experimental branches) sanely into a workflow where they're not being used
- When to sync bookmarks automatically
1. Discussions
For context and other proposals that have been made on the -devel list and elsewhere, see the following:
2. Removing current/active dichotomy
As of 2.4, a bookmark is 'current' if it's the one listed in .hg/bookmarks.current, and 'active' if it is both current and the working directory parent. This creates problems like bug 3682, and is tracked separately as bug 3683.
There are two current proposals to resolve this:
1. Invoke the divergent bookmarks mechanism if the active bookmark would be moved by a pull (see http://markmail.org/message/336pw3v4wh5dtgom). Proposed by KevinBullock. There is currently no easy way to resolve this divergence, since hg merge will refuse to merge with an ancestor. If merge were made to resolve this, we would suddenly have fast-forward "merges", which we've resisted in the past as hard for users to grasp.
2. Keep the 'current' bookmark 'active' even if it gets moved by a pull, and make hg update update to the active bookmark. Proposed by mpm. An explicit hg update REV where REV is not the current bookmark would deactivate the current bookmark (remove .hg/bookmarks.current).
3. Introducing Bookmarks Into Your Workflow
mpm posed the following problem: Alice and Bob are working on a branch. Alice updates to the branch head and commits, then starts some experimental work. She commits and bookmarks her work as alice-work. When Bob pulls and updates, he should move forward one commit. Instead he gets everything in alice-work, which is now the branch head.
To solve this, I propose:
Adding the first bookmark to any named branch also creates an implicit default bookmark on that named branch, with the same name as the branch[?]. This implicit per-named-branch default is created regardless of whether the bookmark was added by the bookmark command, push, pull, or clone.
The implicit bookmark for the current branch is treated as active if no other bookmark is active.
No implicit bookmark is created on any named-branch without other bookmarks.
4. Command Behavior with Bookmarks
4.1. bookmark
Make hg bookmark -f deactivate the current bookmark when moving it.
Make hg bookmark MARK activate MARK if it points to a working dir parent, without requiring --force.
4.2. clone
Clone all bookmarks.
Update to '@' if it exists, otherwise fall back to 'default' or 'tip'.
4.3. pull
Pull all bookmarks.
If you don't want to expose the bookmarks, then mark the changesets secret; this leads us to:
4.4. commit
Add an option that commits the working directory as secret and creates a bookmark (http://markmail.org/message/vx7ub3pojxlccgdx).
4.5. push
hg push -B BOOKMARK pushes only the changesets through BOOKMARK. I.e., it is equivalent to hg push -B BOOKMARK -r BOOKMARK.
Warn (with hint) when pushing changesets that are bookmarked without pushing the bookmarks (suggested by marmoute: http://markmail.org/message/pxemyessq6ek7ynw).
The above proposed behavior is a compromise between local-only bookmarks and topic-branch bookmarks. Those who are used to topic branches in Git are also used to naming them explicitly to push them. And to quote: "Yes, push and pull are definitely asymmetrical. This should be no surprise to anyone who's used a rope." (http://markmail.org/message/mlxueu2lnxi7ewq5)
4.6. update
Update to a bookmark named explicitly on the command line makes that bookmark active.
Bare update moves the active bookmark forward.
- Bare update with no active bookmark updates to the implicit branch-default bookmark if it exists (see above).
- What if it doesn't exist, i.e., how/when to add the implicit bookmark to old repos?


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There are many known challenges for breastfeeding moms. Nipple soreness, low milk supply, poor hygiene in public nursing facilities, straight-up societal ignorance… The list goes on. But, money? Despite all of these other roadblocks, most new moms have heard someone herald the benefits of "free milk." Now, according to a new study by sociologists Phyllis Rippeyoung and Mary Noonan, it looks like that sound-bite is inaccurate -- economics may be to blame for mothers not being able to nurse their babies for as long as they should.
The American Academy of Pediatrics recommends breastfeeding for one full year, but government statistics show that only 23.8 percent of moms do so -- 74.6 percent start off nursing, and only 44.3 percent make it to the six-month mark. And while there are doctors, lactation consultants and a host of products to help moms overcome the physical hurdles, there has been little research into how to help them with other roadblocks.
Researcher Phyllis Rippeyoung, one of the researchers who wanted to investigate this situation further, told MSNBC that her own experience made her curious about how work -- and therefore money -- impacts nursing.
"I was a grad student at the time driving back and forth between teaching and classes, and my milk was drying up since I couldn't drive and pump at the same time. It was a very difficult thing, but I had to stop breast-feeding. If I'd continued I couldn't have worked at the same time," she said.
What she found, along with co-researcher Mary Noonan is that mothers who "breastfed for six months or more suffered 'more severe and more prolonged earnings losses' than mothers who breastfed for a shorter amount of time, or not at all," Miller-Miccune reports.
Out of 1,313 women who participated in their study, moms who breastfed for "long durations" saw a steeper decline of income earned in five years than moms who did not. Researchers accredit more time spent out of work and less hours worked as reasons for their findings.
Obama's health care reform legislation requires employers to provide nursing mothers with breaks and a place to pump. While many companies do strive to comply, women still face challenges handling both work and breastfeeding -– pumping at the office means a few hours away from the desk. And still, other women may only have a bathroom in their workplaces making the practice even more difficult to maintain.
NY Times columnist, KJ Dell'antonia points out that many mothers won't be surprised by the findings. "It comes … from the annals of 'duh:' we knew that," she says. Simply put: Moms who breastfeed can't spend as much time working as those who do not.
But, perhaps these new findings will provide greater encouragement for companies to support working mothers when they return after a maternity leave. Moms and "lactivists" are in a seemingly never-ending fight to gain acceptance for breastfeeding wherever and whenever a baby is hungry. Most recently, the City of Seattle passed a law that makes breastfeeding a civil right, meaning it is now illegal to ask a mom to stop nursing in any given place. However, beyond legislative rights, Dell'antonia identifies "that not every woman has that 'choice' available." Mothers who work outside the home are only allotted 12 weeks maternity leave.
Researchers noted that long-duration breastfeeders are "more likely to be married to college-educated men who make enough money to support the family while the wife takes a leave of absence". Miller-McCune's Tom Jacobs says there is a clear explanation for a wide gap between moms who breastfeed and moms who don't -- some women, especially those in lower income brackets, may have "a lack of options," he writes.
The study suggests that one solution "would be to pass a federal law protecting women's rights to breastfeed at work" that is implemented more strictly than the 2010 health care reform act.
Jacobs writes that "it's not enough to simply tell mothers about the benefits of breastfeeding. Real changes need to be made in both the home and at the workplace to make it feasible for more women to simultaneously earn a living and nourish their baby."


text:
Tagged: radiation alert USA
Full Meltdown At Fukushima: Radiation Levels In Nearby Seawater At 3,000 Times Above Normal
Copyright 2011-3011 Alternative News Forum, All Rights Reserved.
Had you read this description of what actually happened during one of the Fukushima reactor explosions ANYWHERE in the USA mainstream media?
UK Nuclear Expert: "There were a huge number of spent fuel rods sitting on top of the reactor, so when it exploded, and everybody saw it exploding, all those fuel rods went up in the air. And as we now know, it has melted down."
Related Articles
- Japan Radiation Health and Safety Update 3.26.11 (alligatorfarm.wordpress.com)
- Radiation in seawater near Fukushima reactor spikes again (americablog.com)
- Japan Nuclear Crisis: Highest Radiation Levels Detected in Seawater (abcnews.go.com)
- High radiation in seawater near leaking nuclear plant in Japan (theglobeandmail.com)
- Radiation levels soar in water near Fukushima plant (ctv.ca)
- Residents of Japan Instructed to Remain Indoors on 3.31.11 Due to Large Radioactive Plume from Fukushima Plant (alligatorfarm.wordpress.com)
- Japan: radioactivity levels spike in seawater near Fukushima (boingboing.net)
- Setbacks mount at Japan's crisis-hit nuclear plant (genomega1.wordpress.com)
- FUKUSHIMA: Highly Radioactive Water Has Leaked Out Of The Nuke Facility (businessinsider.com)
- FUKUSHIMA: Record-High Levels Of Radioactive Iodine Detected In The Ocean (businessinsider.com)


text:
Leather Zippered Hobonichi Weeks Cover - Crazy Horse Forest Green
This crazy horse forest green leather Zippered Hobonichi Weeks Cover is the perfect for solution for an all-in-one Hobonichi Weeks notebook holder. It allows you the ultimate flexibility in carrying your everyday essentials, with the security of the sturdy zipper so nothing falls out.
100% Handmade in Turkey
Color/Finish:Crazy Horse Forest Green
Distressed brown color showing a lot of different brown under-tones including tan, mocha and hickory. Ages and softens quicker compared to regular leather. Suede feeling finish.
Size:When closed: 12 x 23 cm (4.7 x 9 inches)
- 100% vegetable tanned cow leather
- Hand stitched using waxed polyamide thread
- Sturdy YKK zipper
The left panel features 6 credit card size pockets, one long pocket for your notebook and rulers, one transparent ID card holder, and one large pocket which is great for keeping your cash, receipts or a mobile phone (iPhone 7 plus fits easily).
We included a special pen loop which is made from 60% leather and 40% hidden elastic. The loop fits any pen or pencil whether it's a Caran Dache 849 or a pelikan 1000 fp.
The right panel includes a leather pocket and another hidden pocket underneath for extra storage space.
Customer Reviews
As always, beautiful workmanship.
Great product and excellent craftsmanship love it
My husband bought this cover for me for our anniversary. It is well made from a lovely rich feeling leather. Some reviews said it was very orange so I took a picture comparing it to a brown and an un-dyed leather. I feel it is more of a camel colour than brown. I love it and think it will age beautifully.
Beautiful as always! My second item from Galen and I will be back for more. Great, personal customer service and order updates. Highly recommend
This is a really nice product. The quality of the leather is excellent, fast shipping, and the fact that you can have your initials on it makes it special....missed the Evil Eye stone though...
But I´m really happy with this cover!! :)
Leather Zippered Hobonichi Weeks Mega Cover - Crazy Horse Forest Green
OK. So maybe not quite yet, since this review is being written during our Covid-19 'lockdown'. But eventually this will pass and then I can use the Hobonichi Week's zippered cover to fit my passport, documents and notebook to sketch all my great adventures. Even if those are just ones where I sit in my parked car and
look out the windscreen. The leather gives the notebook firm support and the zipper holds items so they remain secure.
I absolutely am in love with my purchase! This keeps everything that I usually have in a couple different spots all together which is AWESOME! The green color is perfect, the zipper is smooth and my hobonichi fits with room for stickers, small pads etc. Excellent!
Perfect for everyday or travel. Wallet/holder for Hobonichi weeks is really nice.
So glad I found your company.
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Wild White Fish Sampler
4-fish combo | Product #FSA009
Seafood connoisseurs know that each variety of white fish offers its own special appeal. Our sampler pack offers a convenient way to explore the unique features of four fabulous varieties of wild-caught white fish.
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Sampler Features
- Sustainably harvested
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Seafood connoisseurs know that each variety of white fish offers its own special appeal.
Our sampler pack offers a convenient way to explore the unique features of four popular varieties:
- Wild Alaskan Cod – Two 6-oz. skinless-boneless portions
- Wild Alaskan Halibut – Two 6-oz. skinless-boneless portions
- Wild Alaskan Sablefish – Two 4-oz. skin-on, bone-in portions
- Wild Petrale Sole – 1 lb. bag of skinless-boneless fillets (2 to 4 fillets per bag)
Wild Alaskan Halibut and Cod
Both of these fish are light and lean, yet wonderfully moist and slightly sweet.
Their firm textures stand up to a variety of cooking methods, including grilling, while their mild flavors work well with a broad range of seasonings and sauces.
Wild Alaskan Sablefish
Because it lives in deep, cold waters, Alaskan sablefish (AKA black cod) accumulates far more fat – and omega-3 fatty acids – than most other fish, making it incredibly luscious. In fact, it provides more omega-3s per ounce than every wild Pacific salmon species except king.
The incredible lusciousness of sablefish explains why it's also known as "butterfish", and why one Vital Choice customer called it "the chocolate of fish".
Wild Pacific Petrale Sole
Petrale Sole features a particularly delicate flavor and texture, making it a great choice for those who prefer their fish extra mild.
Despite its name, this elegant fish is related more closely to flounder than to other varieties of sole.
Average Ratings: 4.5
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President calls on Verkhovna Rada to cancel winter recess
He wrote an official letter to the Speaker
President Victor Yushchenko wrote an official letter to Speaker of the Verkhovna Rada Arseniy Yatsenyuk. In his letter President suggested that parliamentarians cancel their winter recess, according to the President`s press-office. According to V. Yushchenko some urgent tasks stand before Verkhovna Rada therefore he proposed that deputies prove their will to effectively work for the good of nation and not interrupt their legislative work.
Regarding this President believes that new parliamentary session of the Verkhovna Rada should open on January 22, not in February as scheduled. V. Yushchenko confirmed his readiness to present before parliament an annual address. In this address he shall outline main directions of country's development during this year as well as in the future.


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Garnish with Fresh Fruit
If you're looking for ways to dress up cupcakes without loading on a lot of high-calorie toppings, experiment with fruit. Play with different methods to slice and display your pickings. You might be surprised by how many ways you can cut up star fruit, strawberry or mango. Or, you can mash the fruit so it takes on the consistency of jam, and use that as a substitute for sugary frosting. For more decadent flavor, spread the fruit onto the cupcake crown before adding a dollop of whipping cream or layer of frosting. Generously pile on fresh fruit, or place only a few pieces artistically, depending on the look you're going for.


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Five Klebsiella pneumoniae isolates with reduced susceptibility to tigecycline (MIC, 2 μg/ml) were analyzed. A gene homologous to ramR of Salmonella enterica was identified in Klebsiella pneumoniae. Sequencing of ramR in the nonsusceptible Klebsiella strains revealed deletions, insertions, and point mutations. Transformation of mutants with wild-type ramR genes, but not with mutant ramR genes, restored susceptibility to tigecycline and repressed overexpression of ramA and acrB. Thus, this study reveals a molecular mechanism for tigecycline resistance in Klebsiella pneumoniae.
Klebsiella pneumoniae is an important pathogen of nosocomial infections, including urinary tract infections, pneumonia, wound infections, and sepsis (22). Klebsiella pneumoniae rapidly acquires resistance to most commonly used beta-lactam antibiotics by different mechanisms, including expression of extended-spectrum beta-lactamases (ESBLs), plasmid-mediated AmpC beta-lactamases, and recently also carbapenemases (29). Isolates are also frequently nonsusceptible to fluoroquinolones and aminoglycosides, leaving only few if any treatment options, and even infections with untreatable, panresistant strains have been reported (6). Infections with such multidrug-resistant (MDR) pathogens represent an important field of application for treatment with the recently introduced antibiotic tigecycline (8, 14, 20, 30), the first member of the novel class of glycylcyclines (19). It has an extraordinarily broad spectrum of antibacterial activity, covering most Gram-positive, Gram-negative, and anaerobic pathogens, including vancomycin-resistant enterococci (VRE), methicillin-resistant Staphylococcus aureus (MRSA), and ESBL- and carbapenemase-producing strains (8). Unfortunately, the emergence of resistance to tigecycline in Klebsiella pneumoniae isolates has already been reported (25, 28).
Overexpression of RamA, which is a positive regulator of the AcrAB efflux system, has been observed in tigecycline-resistant Klebsiella pneumoniae strains (2, 25, 28) and also in tigecycline-resistant Enterobacter cloacae isolates (11). Furthermore, AcrAB and related efflux pumps which confer resistance to multiple antibiotics, including tetracyclines, fluoroquinolones, chloramphenicol, and others (21, 23), have been implicated in resistance to tigecycline in several other species (4, 5, 9-12, 16, 26, 27, 32). The overexpression of ramA seemed to be causative for overexpression of AcrAB in Klebsiella pneumoniae and Enterobacter cloacae, but the molecular basis of ramA upregulation could not be defined in these species. We were recently able to show that upregulation of ramA and consecutively AcrAB in a tigecycline-resistant Salmonella enterica isolate was due to an inactivating mutation in ramR, a repressor of ramA (1, 13, 17, 24) in Salmonella (9). How ramA is regulated in bacteria other than Salmonella is currently unknown.
We collected five independent Klebsiella pneumoniae isolates from our diagnostic service, and they exhibited suspiciously small disk diffusion zone diameters (<19 mm), and further analyzed these strains. For tigecycline, MICs were determined by broth microdilution with a commercially available tigecycline panel (Merlin Diagnostika GmbH, Bornheim-Hersel, Germany) using freshly prepared (<12 h old) Mueller-Hinton II broth (BBL, BD Bioscience, Sparks, MD). For ciprofloxacin and chloramphenicol, MICs were determined by Etest (AB Biodisk, Solna, Sweden). MICs were interpreted according to the European Committee on Antimicrobial Susceptibility Testing (EUCAST) clinical breakpoints (for tigecycline, ≤1.0 μg/ml is susceptible, 2.0 μg/ml is intermediate, and >2.0 μg/ml is resistant; for ciprofloxacin, ≤0.5 μg/ml is susceptible, 1.0 μg/ml is intermediate, and >1.0 μg/ml is resistant; for chloramphenicol, ≤8.0 μg/ml is susceptible and >8.0 μg/ml is resistant). All five isolates exhibited MICs of 2 μg/ml, which was interpreted as intermediate. Testing of 12 randomly collected Klebsiella pneumoniae patient isolates with disk diffusion zone diameters of >19 mm uniformly revealed MICs of 0.25 μg/ml. Resistance to tigecycline in Klebsiella pneumoniae has previously been linked to overexpression of ramA (28). Because we recently found in a tigecycline-resistant Salmonella isolate that ramA overexpression was due to a mutation in ramR, a known negative regulator of ramA (9), we asked whether a similar mechanism is instrumental in Klebsiella. A BLAST search identified a predicted Klebsiella pneumoniae protein (accession number YP_001334235) with 63% identity to Salmonella RamR (NP_459572.1). Strikingly, the gene for this protein is located directly upstream of the Klebsiella pneumoniae ramA gene (YP_001334236.1) in a head-to-head arrangement (Fig. 1), a genomic organization reminiscent of the respective situation in Salmonella. The intergenic region between ramR and ramA additionally harbors a predicted gene, romA, with homology to beta-lactamase genes. It was previously shown not to be involved in the ramA-mediated MDR phenotype (7), but if expressed, it may be coregulated by RamR due to its genomic localization, albeit with unknown significance. Interestingly, a putative palindromic binding element for RamR mutated in some fluoroquinolone-resistant Salmonella isolates (1, 13) is highly conserved in Klebsiella pneumoniae and located in the intergenic region between ramR and ramA (nucleotides 622742 to 622762). These similarities strongly suggest that the identified gene represents the Klebsiella pneumoniae homologue of Salmonella ramR.
We amplified the ramR gene and the surrounding genomic region from the tigecycline-resistant strains and the 12 randomly collected strains with MICs of 0.25 μg/ml and performed sequence analysis (forward [5′-CTGCAG-TGCCCGGTGAACCCTGGCGT] and reverse [5′-CTGCAG-ATTTGCTGATTCAGCAGCGAC] primers). In all five non-tigecycline-susceptible strains, mutations in ramR relative to the reference sequence Klebsiella pneumoniae subsp. pneumoniae MGH 78578 (CP000647), as depicted in Fig. 1, were detected. Four strains (UR11100, VA14419, VA14743, and VA21266) harbored deletions, insertions, or point mutations leading to a premature stop codon, which result in predicted truncated RamR proteins highly likely to be nonfunctional. VA6048 harbored two mutations leading to amino acid exchanges in the coding region of ramR. None of these mutations were found in the 12 tigecycline-susceptible strains. Instead, two different silent polymorphisms (594G→T and 150G→A [gene]) were detected and two strains harbored polymorphisms in the ramR gene, which resulted in amino acid exchanges (VA21490 harbored two exchanges, 437A→G [gene]/146I→T [protein] and 454A→T [gene]/152Y→N [protein], and VA21488 harbored one exchange identical to the first in VA24190, 437A→G [gene]/146I→T [protein]). We cloned the ramR genes of all the mutants, of a Klebsiella pneumoniae strain with a wild-type (WT) MIC to tigecycline, a wild-type sequence of ramR (from VA12262), and ramR sequences of the two strains (VA21488 and VA21490) harboring the coding polymorphisms together with the surrounding genomic regions into the PstI site of the pACYC177 vector using PCR products with the forward and reverse primers (see above). All constructs were verified by sequencing. Two of the mutant strains, VA6048 and VA14743, were amenable for transformation. Transformation of VA6048 and of VA14743 with wild-type ramRVA12262 [Klebsiella pneumoniae VA6048 (ramRVA12262-WT) and Klebsiella pneumoniae VA14743 (ramRVA12262-WT), respectively] lowered the MIC for tigecycline in both strains from 2 μg/ml to 0.25 μg/ml, as shown in Table 1. Both ramRVA21488 and ramRVA21490 lowered the MICs for tigecycline of VA6048 and VA14743 to the same extent as ramRVA12262-WT (data not shown), indicating that the amino acid exchanges represent nonfunctional polymorphisms. In contrast, introduction of any of the mutated ramR genes (ramRVA6048, ramRUR11100, ramRVA14419, ramRVA14743, and ramRVA21266) or the empty pACYC177 vector did not affect the MIC for tigecycline in VA6048 or VA14743. These findings suggest that the identified ramR homologue is involved in resistance to tigecycline and that the identified mutations in the nonsusceptible strains are functionally relevant. The AcrAB system is involved in resistance to antibiotics from multiple classes. Thus, we also tested MICs for ciprofloxacin and chloramphenicol in our strains, as both are known to be substrates of AcrAB. Consistent with the findings for tigecycline, MICs for ciprofloxacin and for chloramphenicol of VA6048 and VA14743 were lowered when wild-type ramR was introduced but remained unchanged when mutated ramR or empty pACYC177 vector was transformed (Table 1). These results strongly imply that ramR in Klebsiella pneumoniae is involved in the regulation of AcrAB in a manner similar to that in Salmonella.
Next, we directly analyzed the influence of Klebsiella pneumoniae ramR on the transcriptional expression level of ramA by Northern blot hybridization (hybridization probes for ramA were generated with primers 5′-ATGACGATTTCCGCTCAGGTGA and 5′-CAGTGGGCGCGACTGTGGTTC, and those for 16S rRNA [rrsE] were generated with primers 5′-TTGACGTTACCCGCAGAAGAA and 5′-TCTACAAGACTCTAGCCTGCCA; these were labeled with [α-32P]dCTP [Hartmann-Analytic, Braunschweig, Germany] by using the Megaprime DNA labeling system from GE Healthcare). We also used SYBR green quantitative reverse transcription-PCR (qRT-PCR) using the qPCR Core SYBR green I kit from Eurogentec, Seraing, Belgium (primers used for qRT-PCR are the same as for the generation of the Northern blot hybridization probes except ramA-rev-qPCR [5′-CAGCCGTTGCAGATGCCATTTC]). RNA was isolated with the RNeasy kit (Qiagen, Hilden, Germany). First, expression levels of ramA in the 12 randomly selected Klebsiella pneumoniae strains with MICs of 0.25 μg/ml were compared to those in the five nonsusceptible strains by Northern blot hybridization. Three micrograms of the isolated total RNA was separated by electrophoresis in a gel containing 1% agarose and 1.2% formaldehyde and was subsequently transferred to a nylon membrane (Macherey-Nagel, Dueren, Germany) by neutral capillary elution in 20× SSC (3 M NaCl, 0.3 M trisodium-citrate dehydrate). Hybridization was carried out at 65°C in 10 ml hybmix (7% SDS, 10% PEG 20000, 0.22 M NaCl, 1.5 mM EDTA, 15 mM sodium phosphate, 5 μg/ml sonicated salmon sperm DNA, 500,000 cpm specific probe) overnight, washed three times at 65°C with 2× SSC-0.1% SDS, and then exposed to Kodak MS autoradiograph films. While expression of ramA was uniformly low in strains with wild-type MICs to tigecycline, ramA expression was very prominent in the nonsusceptible strains (VA6048, UR11100, VA14419, VA14743, and VA21266), suggesting massive upregulation (Fig. 2A).
For qRT-PCR, RNA was pretreated with DNase I (Roche, Mannheim, Germany) and then reverse transcribed with the SuperScript kit (Invitrogen, Karlsruhe, Germany). qRT-PCRs were run on a Rotor Gene Q cycler (Qiagen, Hilden, Germany) with 45 cycles of 20 s at 95°C, 20 s at 60°C, and 30 s at 72°C. Data were analyzed by using the 2−ΔΔCT method (15). Quantification by qRT-PCR demonstrated 25-fold to nearly 50-fold upregulation in the nonsusceptible strains compared to VA12262-WT, which served as the reference strain (Table 1). Furthermore, qRT-PCR of acrB (forward primer, 5′-TTAATACCCAGACCGGATGC; reverse primer, 5′-TGGCCGCGGGCCAGTTAGGCGGTA), a target gene of RamA, revealed concomitant 8-fold-to-15-fold upregulation in the mutants compared to the level for the wild-type strain VA12262 (Table 1). Transformation of wild-type ramR (from VA12262-WT) into VA6048 [Klebsiella pneumoniae VA6048 (ramRVA12262-WT)] and into VA14743 [Klebsiella pneumoniae VA14743 (ramRVA12262-WT)] resulted in strongly repressed ramA expression, while no change in ramA expression was noted in strains transformed with any of the mutated ramR genes from the nonsusceptible strains or the empty pACYC177 vector as analyzed by Northen blot hybridization (Fig. 2B) and by qRT-PCR (Table 1). Again, changes in the expression levels of acrB accompanied those observed for ramA (Table 1). All strains harboring mutated ramR overexpressed acrB in comparison to the wild-type strain VA12262 or the mutants VA6048 and VA14743 complemented with wild-type ramR [Klebsiella pneumoniae VA6048 (ramRVA12262-WT) and Klebsiella pneumoniae VA14743 (ramRVA12262-WT), respectively]. These experiments establish ramR in Klebsiella pneumoniae as a repressor of ramA.
In summary, we identified a gene in Klebsiella pneumoniae with homology to ramR, a repressor of ramA in Salmonella enterica, which is mutated in strains resistant to tigecycline (9) and to ciprofloxacin (1, 13, 17, 24). Our results imply that ramA in Klebsiella pneumoniae is regulated in a manner similar to its regulation in Salmonella and provide a molecular mechanism for tigecycline resistance in Klebsiella pneumoniae. All of our non-tigecycline-susceptible Klebsiella pneumoniae strains harbored mutations in the ramR gene, suggesting that this is a major molecular mechanism for tigecycline resistance in Klebsiella pneumoniae. Though the susceptibilities of all of our strains were clearly reduced compared to those of wild-type strains, none of our strains exhibited full resistance to tigecyline by definition (MIC > 2 μg/ml). However, fully resistant Klebsiella strains have been described previously (6, 28), suggesting that several mechanisms might contribute to tigecycline resistance. Acquisition of mutations in ramR may represent one step in the development of full resistance; however, in certain body compartments like the bloodstream, where only low concentrations of tigecycline can be achieved, an intermediate phenotype may be sufficient to result in therapeutic failure of tigecycline (3, 18). Other resistance mechanisms, like Tn1721-associated tet(A) (9, 31), may be additive and upon acquisition successively result in full resistance. It is particularly worrisome that AcrAB-mediated multidrug resistance can be induced by prior treatment with a multitude of antibiotics. Furthermore, it cannot be unambiguously inferred from the resistance phenotype exhibited by an individual isolate in vitro during routine diagnostic resistance testing. Thus, susceptibility testing to tigecycline of all relevant isolates would be beneficial when tigecyline treatment is an option.
- Received 20 January 2010.
- Returned for modification 7 February 2010.
- Accepted 21 March 2010.
- Copyright © 2010 American Society for Microbiology


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Item description: Letter, 8 July 1863, from William Hope Peek, assistant surgeon with the 2nd Virginia Cavalry, to his sister, Maria Peek, who was at the family's home in Hampton, Va. William died less than two weeks later on 19 July.
[Item transcription available below images.]
Item Citation: From Folder 5 of the Peek Family Papers, #4720, Southern Historical Collection, Wilson Library, University of North Carolina at Chapel Hill.
Item Transcription:
My Dear Sis,
Since I wrote my last letter we have had a series of terrific battles near Gettysburg Pa. The fighting continued for 3 days without any intermission and the last was the hottest of all.
The Yankees were whipped and driven back the first two days, but they retired obstinately and slowly, until they got to a very strong position which they strongly fortified and mounted with 40 pieces of artillery. We opened on them with 110 pieces and there was a perfect continuous roar of artillery. Pickett's Division charged the crest and captured every piece of artillery but then fire was so galling they were compelled to fall back with the loss of every Brigadier and more than half the men and officers of the division. It was a fortunate thing that Corse's Brigade was not there, for many a poor Hamptonian would have measured his length on Yankee soil. The slaughter was horrible. Every Yankee around those 40 pieces of artillery was shot down and immense numbers were killed the first two days.
The army I believe has fallen back from Pennsylvania and is now in Maryland. There seems to be no sign of any retreat into Virginia. The Yankees have been raiding it around our wagons and once succeeded in capturing about 75. I thought at one time I should certainly be taken, and it wd. have gone very hard with me for I was positively ill at the time and they kill all their prisoners who can't keep up with them.
I have had a severe attack of my liver affection and suffered intense agony – riding in a wagon over a very rough road, but am getting better now. I am now resting as it were at our wagon camp, while the assistant Surgeon is doing duty with the regiment – They had a small skirmish yesterday and lost one or two men, but the cavalry have not been exposed to one tenth of the dangers the infantry have gone through.
Like all the rest I am getting tired of this side of the Potomac and am anxious to set my foot once more on Virginia soil. I shall write whenever I can. The old saying is that 'No news is always good news"


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very simple on the back of the flyer; a description of the show, a single image of Toilet Puck, some contact info, the show's logo which is only a mock logo. I have not begun working on the real logo yet.
Monday, October 08, 2007
flyer back
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Collection No 6
Tools and processes for taking back the work week.
Information workers waste an inordinate amount of time orchestrating work rather than doing work. Instead of creating new content to drive our businesses, organizations, and missions forward, we spend our time looking for information and people, and then connecting and coordinating them to ensure that good decisions are made, or that other people can do their jobs. It is all terribly inefficient.
There are some obvious moments when this inefficiency is exposed. For example, the technology tools that support our work—from conference bridges to projectors to screens—often fail to function properly, and we waste time fiddling around with them. But there is a deeper, more insidious inefficiency at the heart of information work, and most information workers are not even aware that we have a problem. Our language betrays our ignorance. How often have you heard people say, "We need to get on the same page," or "I'll try to get some time on your calendar?" These expressions are examples of information workers orchestrating work rather than doing work.
Good statistics on this topic are rare. The research of software companies including Doodle and Atlassian suggests that information workers spend around two hours per day looking for information. We spend an average of 1.5 hours per day in meetings and just under an hour per day scheduling meetings. According to McKinsey & Company, we spend two hours sending and responding to email. Add these tasks up and they take a total of 6.5 hours per day. If we are generous and count half the time spent in meetings as productive content creation rather than alignment, it still means that 50 to 60 percent of an information worker's day is spent orchestrating work.
Information work needs its industrial revolution. We are not, of course, suggesting that we need to move workers into a factory setting—indeed, the "cube farms" of the corporate world are often part of the problem. Rather, information work needs its version of the automation that enhanced the productivity and output of individual craftspeople in the industrial revolution. Admittedly, this shift was also accompanied by painful transitional unemployment, social disruption, and environmental degradation, but over time, the industrial revolution lifted millions out of poverty and triggered a step-function in up-leveling humanity. Done right, the impact of automating the orchestration of information work will be just as dramatic.
The following products, services, companies, and approaches—while not a complete solution—indicate that we are moving toward this goal and provide promising signposts to the future of information work.
Software Metamorphoses
Content creation is a free-ranging activity that is defined not by tools, but by the ability to connect information in different forms. Yet today we are forced to work within the confines of software capabilities, and that constraint shapes the way we approach content creation. Most applications are loaded with features that are rarely all relevant at the same time. Moreover, in the enterprise context, information workers can hardly use content consumption software to create anything new. Consider the plight of the researcher who finds various charts, figures, and data in PDF format and must then use various tools to recreate or reference each type of information as she creates unique content. The researcher will jump from application to application without questioning that routine. Why?
A more efficient approach would be for the software to arrange itself around the content creation activity at each specific point in time, adapting to personal workflows and contexts. In this scenario, the software would learn from the data in the creation process instead of just following instructions. Today we have an analogous experience with predictive text engines, which recognize patterns in the way we write. They suggest, with increasing accuracy, complete words or phrases as soon as we type familiar letters. Using a similar logic, programs originally packaged in different applications would emerge into the content creation process as individual or recombined services at the precise moment when they are needed. Such an orchestrating software layer would be infused with predictive logic and learning capabilities; it would serve the information worker before serving applications.
A few technologies are charting a path toward this vision. Products such as IFTTT and Resonance (formerly Atooma) allow users to choreograph and automate the interaction between programs and services according to personal preferences. Microsoft first enabled users to embed a spreadsheet into PowerPoint and work on it without switching to Excel, and later developed live tiles in Windows, which partially reduced the need to jump from application to application. VMware runs applications from different systems in a unified work space. Apple introduced uninterrupted workflows between devices with Continuity, and with iOS 8 moved toward a more personalized software experience by supporting the integration of functionalities from a broad range of applications into a single application. Together, these technologies offer glimpses of the software metamorphoses required to meet the needs of the modern information worker.
Knowledge Multiplier
Knowledge management is a huge challenge for information workers. People join and leave organizations so frequently that institutional memory is fleeting. Indeed, project-based work in which people come together temporarily and then disperse is challenging the very notion of institutional memory. In larger firms, different groups of information workers may tackle the same problem without being aware that others are doing the same.
Managing knowledge to give people the information they need when they need it is the baseline requirement for efficient knowledge work. Offering knowledge multipliers to information workers—such that they are armed with information they did not even know would help them—should be the ambition of those interested in moving beyond the baseline.
We see hints of this at the feature level of some emerging offerings. For example, frog client Unify recently launched its Circuit product, which contains two knowledge multipliers: Thought Trails and Intelligent Spaces. The communication and collaboration tool analyzes content and communication patterns to suggest connections with others in the firm working on similar challenges. Conference calls are transcribed and made searchable, together with shared documents, allowing the system to recognize patterns across the organization and to offer insights. The information worker does not have to go looking; the relevant content is curated and offered up at the right moment. Another example comes from the work of Quid. This company's intelligence platform makes connections across complex data sets to enable the fast and comprehensive generation of insights.
We want to take this process to its logical conclusion: knowledge multipliers will be tools capable of extending the intellectual capacities of information workers. They will not just optimize the process of collecting and making sense of information, but will fundamentally aid in the creation of new information at unprecedented speed, quality, and volume.
Sentient Workplace
Many recent frog projects involve thinking through products and services that take advantage of sensors and sensor networks to enhance human experience. A great example in the consumer space is the Disney MyMagic+ ecosystem, which uses a wristband to allow park guests to interact with the environment around them. The wristband acts as a ticket, FastPass to rides, wallet, and key to unlock hotel doors. But more than that, it allows Disney characters to greet guests by name and interact with them in a personal way. It is tailoring the environment to create an individualized experience.
Another great example is the use of sensors in cars to adjust an experience. Using sensors in the seat and steering wheel, or coupling facial recognition technology with emotion mapping, allows us to build cars that calm us when we are stressed or wake us up when we are tired. There are many other examples and use cases across multiple industries. This movement is characterized by widely distributed sensing technology, and it is ripe to be applied to information work.
What if we could draw on our physiology, emotional state, and mood to determine the optimal time to perform various tasks? At frog, we know that our best ideation occurs when participants are well rested, calm, and focused. What if our task lists for the day could adjust based on biometrics and historical information on optimal performance?
What if the entire firm was sentient? By combining and analyzing data from sensor networks in the physical environment, with awareness of the content being generated by information workers at any given point in time, we could create a working environment that is akin to a sentient being and capable of adapting to the conditions of its inhabitants.
At frog, we move ourselves to various locations around the work space based on our individual work styles and the particular task at hand. For example, in our San Francisco studio, we have the Zen Lounge, which contains both seated and standing desks equipped with noise-canceling headphones, where we go to complete "heads-down" tasks. Other work areas are more collaborative and noisier. What if spaces adjusted to the work and people using them, instead of the other way around?
Environmental sensors, knowledge multipliers, and software metamorphoses will redefine the way workplaces and tools support the activity of information workers. Done right, this revolution has the capacity to dramatically increase the quality and productivity of information workers. It will free them to focus on the creative tasks that add the most value to their organization, while eliminating the frustrating, time-consuming aspects of today's information work. This is an opportunity to advance the future of work, which, like the industrial revolution, promises exponential impact for businesses and workers alike.
Timothy Morey
Tim leads a global team of business and product strategists who work alongside frog designers and technologists to bring game changing innovations to market. He has worked in Silicon Valley for 15 years in a variety of product, strategy and marketing roles.
Roberto Veronese
Roberto Veronese has over 10 years of experience in shaping strategies and designs for innovative products and services in a broad range of industries and markets.


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Jeanette Clausen
Jeanette Clausen is Professor of German at the University of Arkansas at Little Rock (UALR). She came to UALR in 2007 after retiring from Indiana University Purdue University Fort Wayne, where she taught German and Women's Studies and served for ten years as an associate vice chancellor for academic affairs. She has published articles on Verena Stefan, Helga Königsdorf, and Christa Wolf. She is the translator of Irmtraud Morgner, The Life and Adventures of Trobadora Beatrice as Chronicled by her Minstrel Laura. A Novel in Thirteen Books and Seven Intermezzos. (Lincoln and London: University of Nebraska Press, 2000), and has also published translations of short works by Lillian Faschinger, Jeannette Lander, and Luise Pusch, among others. Besides German women writers, she is also interested in higher education administration and has published on faculty roles and rewards.


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Groups have been an important part of the WhatsApp experience, whether it's family members connecting across the globe or childhood friends staying in touch over the years. There are also people coming together in groups on WhatsApp like new parents looking for support, students organizing study sessions, and even city leaders coordinating relief efforts after […]Continue Reading
The recent 100 updates of Google at i/O 18.
That's a muffle! Google I/O announced a great deal to think back on and a ton to anticipate, from supportive highlights influenced conceivable with AI to refreshes that assist you to build up a feeling of advanced prosperity. Here's a list of 100 I/O declarations, with no specific request—since we don't play top picks.Continue Reading
Instagram Adds a List of New Tools Including AR, Messenger, Creators and Brands.
Instagram declared a rundown of new changes going to the stage, including an overhauled Explore area, new choices for sharing to Stories and another "domineering jerk channel" for remarks. Highlights like the new increased augmented reality (AR) sift are as of now moving through while choices like the video talk and new Explore are as […]Continue Reading
WhatsApp Group Video Call Are Coming Soon
WhatsApp would soon be including a gathering video calling highlight to the famous end-to-end informing application, making it workable for its more than billion clients to have eye to eye discussions with different individuals at once. The dispatch of WhatsApp assemble video calling, the organization trusts that the informing application will turn out to be […]Continue Reading
Google Launches New Google My Business API, New Dashboard to Manage Multiple Locations
Google announced most recent API refresh, Now a single registered account on GMB will be able to manage an unlimited number of locations.where they are including more highlights like offer posts and shipper portrayal so accomplices can keep on offering Google My Business' most recent highlights to their clients proficiently and at scale and out […]Continue Reading
Facebook Announces Dating Features
Facebook announced the new dating features which is one of the most stunning declarations, and greatest diversions of the day. Facebook will take off select in dating usefulness for clients in light of the fact that everybody needs another dating application. The administration will enable clients to fabricate dating profiles isolate from their essential profiles […]Continue Reading
Here's a snappy once-over of the new Gmail
Gmail's new look causes you accomplish more. Tap on connections—like photographs—without opening or looking through extensive discussions. It utilizes the new nap catch to put off messages that you can't get the chance to the present moment or effectively get to different applications. It helps to utilize on a regular basis similar to Google Calendar, […]Continue Reading
Alexa Introduces New SEO Tools
Alexa.com now added a new SEO tool in their suite of the competitive analytic tool. Alexa.com has enabled gap analysis that lets marketer to find opportunities and to improve search performance and brand awareness with a shortcut. With the introduction of competitor backlink checker and new updates to competitor keyword matrix, now marketers can close […]Continue Reading
New Google Search Console Adds Search Appearance Filters And More
You can now filter your Google search performance reports by Rich Results, AMP non-rich results, AMP articles, Job listing and Job details. The new version of Google search console has added a filter in the performance report for "search appearances". Search appearance filter that is also available in the old search control's search analytics reports […]Continue Reading
Shutting Down Goo.gl and Transitioning to Firebase Dynamic Link
Google launched the URL shortener back in 2009 for shortening as a way to help people share link more easily and measure traffic online. Since then many popular URL shortening services have emerged. The way people find content online has also changed a lot on IOS, Android or web format. To refocus, google soon turning […]Continue Reading


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Turmeric root, cinnamon, chia and flax seeds, and dark leafy greens are rich in anti-inflammatory properties. Coconut water is nature's sport drink, containing significant amounts of potassium, mangesium, and other vitamins and minerals. And dark leafy greens like kale are a superfood of cleansing and healing properties.
1 1/2 cups coconut water
1/2 cup frozen mangos or 1 frozen banana
2 leaves of kale (or as much as you can palate)
1 inch fresh turmeric root
1/2 tsp ground cinnamon
1 tb chia and/or flax seeds
optional: add a sugar free protein powder for post workout or meal replacement
Blend all together on high and drink up!


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We collect the best products of Chios for you!
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Erin Richards (The Quiet Ones) stars in the highly anticipated new drama, Gotham. Set to make its debut on FOX this fall, Richards plays Barbara Kean, who is engaged to a current Comissioner James Gordon. I sat down with Richards to discuss her role, what scene comes to mind when she thinks of Batman, how she lightens her dark days, and much more!
Side note: After watching the Gotham pilot at Comic Con this year, I can guarantee this is the MUST-SEE new series of the year!
Gotham airs September 22 on FOX.
"Gotham" Official Extended Trailer


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This week I want to speak to the parents about golfing with your kids.
With the sunshine and rolling greens, it can be a great day of one-on-one time with your child.
However, the number one thing I can tell parents before they set out on a day golfing with a child is to set realistic expectations.
In other words, don't bite off more than your child can chew!
Children at a young age do not (and should not) know about the frustrations that go along with golf; it should be all about the fun. If a child has a bad experience with you while golfing, they probably won't be fired up to try it again so lighten up!
Kids have a short attention span so don't spend five minutes droning on about the perfect grip. Speak in their terms and don't worry too much about technique. Always take time to talk to them about safety.
At the driving range, they should be in the stall in front of you not behind – keep them in your line of sight at all times.
Show them where to stand when someone is teeing off don't just tell them.
I wouldn't recommend trying to play nine holes with your child until you've spent some time at the driving range and practice green.
Turn these moments into fun games with putting and chipping contests. Celebrate small successes. Kids love being praised and by all means do not criticize them! When you do attempt to get some holes in, take a cart. For most kids, the golf cart is like an amusement park ride. Bring some of their favorite snacks and drinks to help sustain energy.
Golf can be enjoyed by the entire family as long as it is enjoyable.
When you feel your patience waning and junior is whining, it may be time to head back to the clubhouse for an ice cream. Pack your patience and remember, make it about them!


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About the Event
Most people think cities have high-density "pointy" centers and gradually flatter edges—edges that slope to the countryside. This presumed hierarchy has remained unchallenged despite the fact that North American cities, when they were at their most powerful, were flat—homogeneous across large urban landscapes in a form and density that was uniquely American. The form was the grid, and the means of getting around was on foot or by streetcar. In this first manifestation of the American Dream—the Streetcar City—residents produced almost no greenhouse gas from their transportation choices.
At the CTS Fall Luncheon, Patrick M. Condon argued why this form is again desirable for our future quality of life.
Watch video
has more than 25 years of experience in sustainable urban design, first as a professional city planner and then as a teacher and researcher. He started his academic career in 1985 at the University of Minnesota and moved to the University of British Columbia in 1992, acting first as the director of the landscape architecture program and later as the James Taylor Chair in Landscape and Livable Environments. He is the author of several books, most recently Design Charrettes for Sustainable Communities (2008) and Seven Rules for Sustainable Communities: Design Strategies for the Post-Carbon World (2010), both from Island Press.


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Here's a trick question for you. What was probably the most read, almost certainly the top bestseller in the English language, of 1847? To help you out, these books were published that year: Wuthering Heights, Jane Eyre, Vanity Fair, and poetry by Alfred Lord Tennyson.
That's right, the top bestseller of 1847 was Varney The Vampire.
The full title is Varney The Vampire, or The Feast of Blood. It's freely downloadable from several sites if you want a look.
If I'd included non-English books, Varney would have had a close run with The Man in the Iron Mask plus two other books by Alexandre Dumas. Dumas was not only a busy lad himself, but he kept a small factory of authors to churn out books published under his name. Which when you look at how some thrillers are produced these days, shows that publishing really hasn't changed.
Notice that gives us paranormal, plus action/adventure/thriller. Genre rules, and has done since time immemorial.
Varney weighs in at a mere 667,000 words. Imagine trying to get a publisher to read that these days. But then, Varney appeared originally as a serial, so it's probably more accurate to compare it with any modern day series, at which point it becomes standard length. It's shorter than the entire Harry Potter series, for example.
Varney was the first vampire story to hit the big time (Bram Stoker was born that year). It was the first story to give vampires fangs that leave two puncture wounds.
It's also almost as badly written as Twilight. Anyone who can read it from end to end is probably insane (I mean Varney, not Twilight), but it does have some good scenes (Varney again, not Twilight). I particularly liked the bit where Varney challenges an adversary to a duel with scythes in a dark room. I must work out how to steal that.
There's nothing new under the sun, nor under a dark night sky for that matter.
Bestsellers of...1847
4 comments:
- nephite blood spartan heart said...
Ha! Excellent post Gary. No matter what people claim, "We" don't change that much.
- October 27, 2011 at 10:26 AM
- Travis Erwin said...
Great post. Interesting stuff.
- October 27, 2011 at 10:31 AM
- Sarah W said...
To borrow a phrase from our babysitter, Varney would scythe Edward like whoa!
- October 27, 2011 at 1:54 PM
- Loretta Ross said...
Ha! Genre rules! :D I have to say, though, that the only vampire I've ever liked was Count Duckula. I had the misfortune of visiting my niece while her tweenagers watched the first Twilight movie. It was TORTURE!
I so want one of those tee shirts that say "and then Buffy staked Edward. The end." Or, better yet, "and then Dean Winchester ganked Edward. The end."
Thanks for another great post, Gary! :D
- October 27, 2011 at 4:41 PM
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Why CryoTherapy Trumps Coffee
People come far and wide to get a CryoTherapy session that will alleviate their physical inflammation and help them recover from harsh workouts. But despite it being one of the main benefits of Whole-Body CryoTherapy, people are often surprised by the increased energy they gain after their sessions. Their minds are awake and alert, they have an easier time focussing, and that groggy feeling as they reach the end of their work day disappears. This leaves many of them questioning, Why? It's much easier to understand the physical benefits of CryoTherapy, as people are very well versed in the use of Ice Baths and Cold Packs and how cold can help the body, but the energy boost can be a little more complicated; so Cryo Elite Therapy is here to explain!
During a Whole Body Cryo Therapy session, patients are enveloped with hyper-cooled air for 3 minutes, at temperatures as low as -130 degrees Celsius. Because the body is getting so cold so fast, the body goes into "temperature stress", which is a small state of shock. When your body goes into shock, all the blood rushes to your vital organs to protect them.
This process oxygenates your blood and stimulates your vital organs, along with an increased heart rate and small adrenaline rush. The extra stimuli and adrenaline produces a boost of endorphins. Endorphins react with the brain receptors to reduce the perception of pain and increase pleasure feelings. This helps your brain feel more awake, focussed, and energized.
Think about a day where all you did was stare at a computer screen, eventually your eyes might hurt a little, feel dry, your brain will feel a little foggy, and your back stiff; but once you get up and walk around and go outside for fresh air, you body feels much better. That's similar to how CryoTherapy interacts with your brain. It shakes your mind awake for a whole new level of energy and life.
Many patients like to schedule their Cryo sessions around the time of day they tend to start lacking energy, this way they don't have to pay for another cup of coffee. Coffee, while a good quick fix in a pinch, can result in caffeine crashes, and consumed late within the day can affect your sleep, making you more tired the next day, making you drink more coffee, making you more tired the next day, making you drink- yeah, you get it. With Cryotherapy, because everything is happening organically in the body, there's no going over your sugar limit for the day, there's no caffeine crash and no chance of messing up your sleep, in fact, because of the increased circulation during the session, you're actually going to sleep much better than you would normally!
So there you have it, the reason why CryoTherapy is the natural energy boost that can change your day! There's nothing better than having a long day at work, doing a Cryo Session, and having the life and energy to do more than just crash on the couch when you get home, knowing you'll still make it to bed at the right time.


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Motors and Generators
Featured Articles
- The market for metric The future of IEC motors in North America appears bright, in spite of countervailing forces By David Miller, EA Special Correspondent
- The metric difference Why there's no simple correlation between NEMA and IEC motors With trilingual summary By Richard L. Nailen, EA Engineering Editor
- Global in more ways than one Biennial trade show provides all-inclusive coverage of 21st century manufacturing and its humans By the Electrical Apparatus staff
- Future perfect The Trumpf Group's smart factory in Illinois provides a detailed look at the manufacturing plant of tomorrow By Selena Cotte, EA Assistant Editor
- Taxing questions How new tariff and tax rules are likely to affect U.S. companies doing business overseas By William H. Wiersema, CPA, EA Contributing Editor
- Downward and onward! Handled correctly, a demotion can improve an employee's morale and set him or her on the right track By Bill O'Leary, EA Managing Editor
- A common language? When it comes to the use of electrical terminology, Yanks and Brits are an ocean apart By Richard L. Nailen, EA Engineering Editor
- CNC machining and the shop Whether you're working with them or merely around them, a familiarity with CNC machines is becoming increasingly important By the Electrical Apparatus staff
- Smart for all The time has come to open your eyes to the potential of plant automation By Selena Cotte, EA Assistant Editor
Departments and Columns
Editor's Comment In this issue: A world of opportunity in electrotechnology By Kevin Jones
Let's Solve Your Problem In this issue: Questions and answers about standards and motor application Edited by the EA staff
Business briefs In this issue: Electric Motor Technologies of Cincinnati buys a single-phase motor shop ….. Edited by Kevin Jones
Letters Anger over the cancelation of a Chicago coil and manufacturing event
Know your industry A U.S. agency nudges other nations toward humane labor practices … by Matt Raebel
OEMs on the move Plants opening, closing, and expanding around the U.S. Edited by Selena Cotte
Calendar briefs Upcoming events on wind power, robotics, manufacturing, and more …See our online calendar for current offerings, with upcoming events on safety, coil winding, manufacturing, and more Edited by Bill O'Leary
Pumps Leading trends in the global pump market Edited by Kevin Jones
Renewable energy There's a growing demand for wind power—and wind workers Edited by Matt Raebel
Utilities Where in the world is the Smart Grid headed? Edited by Kevin Jones
Say it right When it comes to electrical terminology, Yanks and Brits are far apart By Richard Nailen
Names & faces Recent personnel changes at Nidec and a contractors' association Edited by Bill O'Leary
Deaths Remembering industry figures Adam Willwerth and Timothy Breen
EA reader profile Meet Bill Holland, for whom no job is too big or too small By Selena Cotte
Training briefs Apprenticeship starts see a decline in the U.K. Edited by Bill O'Leary
Standards Could the IEEE's release of its 'dot standards' be any slower? Edited by the EA staff
New books The pragmatist's guide to preventive maintenance Reviewed by Richard Nailen
Puzzle In this issue: Word search… The Editors
Direct and Current In this issue: Manufacturing hums along, and apprentices get a boost Edited by Charlie Barks
And, in every issue: Classified Advertising (Equipment, jobs, businesses for sale, business opportunities and services), Advertising Index, and your favorite cartoons, Moe, Genny and Friends (illustrated by John D'acunto) and Cy's Super Service (illustrated by James Estes)!


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i've an 4 years old P4 524 machine which is carrying vista ultimate too well. but recently i saw that the CPU is idling around 30C..but while handling heavy loads like games or some sound editing works the temp is surging up to 60C! to my knowledge the difference between max & min temp remains within roughly10C. but here its almost 30C. isn't it abnormal to have that kind of big range? is there any way that i can limit the max temp within 45-50C? i believe my case has sufficient ventilation.
"isn't it abnormal to have that kind of big range?"
Don't look for problems that aren't there. Most Prescott owners would love to see those kind of temp readings.
"i believe my case has sufficient ventilation"
Rear exhaust fan + PSU is generally all that's necessary.
Maybe you are thinking of the difference between ambient (room) temp and system temps and the difference between case temps and processor temps.
thanks guys for your replies..yes i dont have any problem with the machine. i've seen the prescott idling at even 14C in the coolest winters. and that wasn't ambient/system temperature...its truely the CPU temp.
If that is accurate (57F) then that must be one cold room.
yes the sys temps might be around 10C..
"yes the sys temps might be around 10C"
That's 50F, so that would mean the average room temp would be in the 40's?
A 30°C swing between idle and load is common with a P4. It's a little alarming if you're used to an AMD Athlon/XP that only displays 10°C swings.
This is the second post with extremely low Prescott temps and users who live in a refrigerator.
Yea Skip, that is what I was pointing out. Must be uncomfortable using the computer with winter coats on.
u guys believe or not what i saw have already told u. yeah it was bloody cold in the room but i didn't measure the temp with a thermometer! CPU fan was running at around 900 rpm.
Who said we didn't believe you? Can't you let us wonder why you (or anyone else) would sit around in a 40°F room.
If your P4 idles at 45°C and pops up to 75° at full load, you're still ok.
Build a fire or something in that room...
well thanks to skip for those tips..especially that one of fire
but right now its summer and even i would wonder thinking of those cool nights but not that much like u! anyways thanks once again.


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Georgian buttons are one thing, but designs for Georgian buttons are a tad unusual, especially if the identity of the designer is known. So here's a leaf from the "Phillp album" housed at Birmingham Archives but now thoughtfully scanned online, at least in part. [Click all images to enlarge.]
John Phillp may have been the "natural" son of legendary Birmingham industrialist Matthew Boulton. He arrived at Boulton's Soho mint and manufactory in 1793, in his mid 'teens, and soon became a talented designer of metalware, medals, tokens and much else. The album is a fascinating browse (start here), containing sketches of all sorts, including the sheet of designs for officers' buttons for the North Yorkshire Militia, presumably for the firm of Boulton & Scale. (In the online image the sheet is reversed, so I've re-reversed it here. Excuse a portion of the website's "watermark" in the close-up.)
Other pages of the album include a design for a drum major's staff head (described as a "hilt") for the Loyal Birmingham Volunteers, and a rather solemn and sensitive image of a teenage boy that may well be a self portrait. Phillp died in his late thirties, in 1815.
The central of the three buttons is listed as 276 in Ripley & Darmanin's English Infantry Militia Buttons 1757-1881 and as 165 in Ripley & Moodie's Local Militia Buttons. I've not seen any evidence that the other two designs were ever manufactured. Presumably this one was the choice of Colonel Lord Dundas.
In the mid 'seventies there was an officer's jacket with buttons of this design on display at York Castle, attributed to the 5th North Yorkshire Local Militia, though Ripley & Moodie list this button for the 2nd NYLM. As the jacket itself was silent on the matter, while a different, unit specific, button is known for the 5th, who can tell? I made a sketch of the jacket at the Castle at the time, but since then it seems to have travelled on to the Green Howards Museum.


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living soul
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a living soul
A person (who is alive). (Often used in the negative to mean "nobody.") Each living soul one meets is a chance to gain a new perspective on life. Our engagement is a complete secret, so don't tell another living soul, OK?
living soul
A person. For example, Every living soul in this town has a stake in the decision to ban smoking, or The place was empty-not a living soul to be found. [First half of 1600s]


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West Coast rap group N.W.A. and music icon LL Cool J have reportedly been nominated for consideration into the 2014 Rock & Roll Hall of Fame.
According to reports, the two rap entities amongst other notable musicians will face-off in hopes of making history.
This year hip-hop acts N.W.A. and LL Cool J have been included among the 16 nominees. Other rock bands included are Nirvana, Paul Butterfield Blues Band, Deep Purple, Peter Gabriel, Link Wray, and the Zombies. N.W.A. was nominated last year, but failed to make it on board. Let's hope the Compton legends will get the accolades they deserve this year. The 29th Annual Rock and Roll Hall of Fame Induction Ceremony will be held in April 2014 in New York. The ceremony will be broadcast on HBO. (Miss Info TV)
A couple years ago, music icon Rakim reacted to receiving a nod for the Hall of Fame.
"I was speechless. You can almost say, "Yeah, I made it," getting nominated to that right there. It's a big accolade. If I get in, it'll definitely put the icing on the cake. To be noticed on that plateau, for me, is enough. It definitely lets you know that you're noticed, appreciated, and somewhat made it in music. But I've got other things to prove. I don't know why, but now it's like [I'm] proving you can be over 40, still be relevant, still be nice on the mic, and you can still be a beast. All of these things. It don't stop with me. I guess with the titles that I've been handed through the years, it inspires me to keep that up. If not, push it further." (Complex)
A few years ago, Def Jam co-founder Russell Simmons vouched his support for the rap mogul.
"Nothing makes me happier than seeing the greatest of all time, LL Cool J, getting nominated to become a member of the Rock N' Roll Hall Of Fame. I remember when Todd was just a young, runaway kid who kept sending his demo tape to Rick Rubin's dorm room. When we first listened to his tape, we knew we had to make Todd part of the Def Jam family. Over the years, Todd made hit after hit, and maybe only to Jay-Z, he has the most hits in hip-hop history...at least in my book. But more importantly than being a hit maker, Todd has always said yes when asked to give back to his community. I have asked him to do many, many things and he has NEVER said no. He is a true friend and someone who truly deserves to [be] immortalized in the Rock N' Roll Hall Of Fame. (Global Grind)
After LL lost out on an induction in 2009, Slaughterhouse's Joell Ortiz was vocal on his issueswith the Rock and Roll Hall of Fame panel.
"how they not let LL cool J in the rock n roll hall of fame yet?," he asked Wednesday (December 16) night. "LL cool J is one of the first rappers that ever reached out to give me encouragement early on. He didnt even know me just a good dude. @menima27 not many at all. Alot of arrogant a**holes in this biz. I got stories yall." (Joell Ortiz's Twitter)
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LIVERPOOL'S success in staging top-class cricket has earned another big game next year.
Lancashire will play the four- day County Championship match against Kent at Aigburth from the Wednesday to Saturday June 26-29.
Talks have been ongoing between Liverpool CC and the Old Trafford committee since last May, when Lancashire played three Benson and Hedges group games at the club's Aigburth home.
The local committee, headed by Liverpool chairman Peter McAvoy, are looking for a commitment to bring top matches to the city each season until at least 2004.
"Lancashire have come back to us with this game because everything went splendidly in May," said Mr McAvoy. "They could not commit themselves until they got the fixtures at the end of October, but we submitted a bid for a game."
Vital sponsorship has again been received from Jaguar (Halewood) and the city council will be offering its full support.
Lancashire endured a traumatic last season, culminating in the replacement of skipper John Crawley with Warren Hegg, now on tour with England in India.
But the Red Rose county has secured the services of Australian Stuart Law, who last season hammered them for three centuries in three days for Essex.