text:
A casual classic done the SOREL way, featuring a seam-sealed waterproof construction and sneaker-like comfort for performance that's ready for anything. The men's Madson Moc Toe Waterproof boot is expertly crafted in rich, supple waterproof leather. Add to that an iconic moc-toe design, and you get a timeless everyday boot for soggy weather and beyond.
A casual classic done the SOREL way, featuring a seam-sealed waterproof construction and sneaker-like comfort for performance that's ready for anything. The men's Madson Moc Toe Waterproof boot is expertly crafted in rich, supple waterproof leather. Add to that an iconic moc-toe design, and you get a timeless everyday boot for soggy weather and beyond.
Best For: Heavy Rain
- UPPER: Available in waterproof full grain leather (1821391 & 1887081) or waterproof nubuck leather (1767231) upper. Synthetic lining. Seam-sealed waterproof construction.
- FOOTBED: Removable molded PU-like EVA, synthetic topcover.
- MIDSOLE: Die cut EVA midsole with full length EVA insert.
- OUTSOLE: Molded rubber.
- Heel HEIGHT: 1 in.
- PLATFORM HEIGHT: 1/2 in.
- BOOT SHAFT HEIGHT: 5 in.
- Measurements based on size 9.
- Style # 1767231
Size Guide
Shipping & Returns
Shipping Information
|Shipping Method
|Expected Delivery Time
|5-7 Business Days
|3-4 Business Days
|2-3 Business Days
Return Policy
Returns are accepted within 60 days of the purchase date. We will gladly accept returns on all purchases made on our website which are in original condition; unworn with tags attached and for footwear with the original box in new condition.
Non-expedited shipments to the following areas can take up to six weeks:
- Alaska
- Hawaii
- Guam
- Puerto Rico
- US Virgin Islands
- APO addresses
Still Have Questions
See our Customer Service section for more details.
Men's Madson™ Moc Toe Boot is rated out of 5 by 88.
Rated 3 out of 5 by Garrett from Sharp eyelets are a common issue Same issue as reported here before, the eyelets of the shoe aren't properly installed so there are very rough metal edges that over a short time (3 months for me), both of my laces had snapped. Warranty claims laces are not covered, and the eyelets MAY be covered after inspection where the customer pays for shipping back to the warehouse.
Date published: 2020-05-26
Rated 4 out of 5 by Tristy from Laces are only downfall The boots are top notch quality and are extremely durable. I can wear them to the bar or out in the woods and they still hold up well. The only issue with these boots is that the metal eyelets chew up the laces in no time. I had to replace my laces 2 months after buying these boots because they broke. It is impossible to find the original laces from sorel, and other laces don't look as nice.
Date published: 2020-05-03
Rated 3 out of 5 by Laddiebones from Very comfortable, cheap soles. I love these boots, I've been wearing them for a little under a year though and the soles of them are peeling off. They are constructed in thin laminated layers of foam and rubber, if the where a solid vibram outsole these boots would be great! Also these sole offer no traction at all, very slippery.
Date published: 2020-04-26
Rated 5 out of 5 by Veronica3 from Versatile Bought the Madson Moc Toe as a 3yr (leather) anniversary present for my husband & he LOVES them. Perfect for work and wearing out. This is his second pair of Sorel boots and he wore out the first pair. Needed 1/2 size smaller than usual for both pairs. Would definitely recommend.
Date published: 2020-04-22
Rated 1 out of 5 by KeithE715 from Soles fell apart I bought a pair of Madiaon Moc Toe in October. Initially I loved the boot, comfortable, very short break in period. They are NOT good on ice and snow, down right treacherous. Around the two month mark, the toe of the sole, on both right and left, began to separate. At that time I reached out to Sorel for a warranty claim and did not receive a reply. Do not buy these boots! Poor quality and clearly not willing to stand behind them.
Date published: 2020-03-27
Rated 5 out of 5 by Boots12345 from New Boots Great boots that feel just right on the foot. Love how the color fades with wear.
Date published: 2020-03-23
Rated 5 out of 5 by djnol from PERFECT CONFORD This Boots are excellent I can wear them all day without feeling tired at the end of the day. Good material, easy to clean, I will buy all the colors.
Date published: 2020-01-29
Rated 5 out of 5 by Rami1313 from Ahead of the Rest Over the years, I've purchased a number of different boots ... some might say I have a real "boot-attachment." But, my Sorels are clearly the best! Their unique style, superb fit and choice of colors have made me the envy of my crew. Why not: Put your best boot forward?!!
Date published: 2020-01-24
Rated 5 out of 5 by Megawatt37 from Great boot This is a quality boot. I have wide feet and had no issues with it pitching and didn't need a break in period. Comfortable right out of the box.
Date published: 2020-01-23
Rated 5 out of 5 by Eric2020 from Great Casual Boot Had these for about 3 weeks and they are very comfortable for long periods of standing. They look great as a casual boot or with some dress casual slacks
Date published: 2020-01-19
Rated 5 out of 5 by CindyD from Perfect Casual men's shoe My husband needed a casual shoe he could wear all day that was more than his Nike or Solomon hiker. He wore these right out of the box with no complaints! The gray color is very modern and doesn't date him. He says they're very comfortable and true to size. WIN!
Date published: 2020-01-16
Rated 5 out of 5 by KILMATIK from Nice, Big Chinese Shoes great boots. I love the quality. I hate that they are made in China. Please change that... might not buy anymore. These boots run half a size big... WHY?!? you should let that be known. overall I love the boot... the quality and look. I also like most of the other boot designs and, after receiving another pair as a gift this christmas, I quickly have adopted Sorel as my brand of choice for boots. Keep up the great design and move the factories out of china when possible.
Date published: 2020-01-15
Rated 5 out of 5 by courtyd from Great, versatile boot I ordered these boots for my husband. He has the same pair in a different color, but also wanted black! He loves the look and fit, they can be easily dressed up or worn casual. Excellent quality, as usual!
Date published: 2020-01-11
Rated 5 out of 5 by csew0517 from Real comfortable! I bought these boots looking for a waterproof, every day shoe to wear during 10 month fall/winter of western New York and these have exceeded my expectations. I wear them to the office and everywhere else!
Date published: 2020-01-11
Rated 5 out of 5 by CorleyP from This is the most comfortable shoe. I bought these boots for my husband for Christmas and he says he will never buy another brand boot. The comfort and quality are excellent.
Date published: 2020-01-05
Rated 5 out of 5 by SKOL2020 from Most comfortable boot ever owned I own numerous Sorel products. This being my first casual/everyday boot and I've been very pleased. From the look... to the comfort...to the construction this boot has it all. You could walk miles in this boot or stand all day in comfort. Nice job Sorel.
Date published: 2020-01-02
Rated 5 out of 5 by phlygyrl33 from Husband's first pair of Sorel's I myself love Sorels and have over a dozen pairs. Finally bought the husband a pair. He said they are very comfortable and he loves them. Saw the same style on sale yesterday so I ordered him the black pair as well. I think this will be the road to him catching up to my collection. Definitely recommend buying these.
Date published: 2019-12-29
Rated 5 out of 5 by StephanieB927 from Amazing boots Great boots! Bought these for my husband and he was over the moon in love with them!
Date published: 2019-12-26
Rated 5 out of 5 by Cade121 from Must have Madison Moc Toe The trifecta! Function, Fit, Fashion! This boot is perfect for adverse weather or simple function and fashion! Its rugged construction doesn't take away from the sleek look of the boot! I have never received more complaints on a boot as I do when I wear these! It's as comfortable as a slipper but holds up to the weather in the Northwest! Guys think they look cool, girls always compliment the outfit! Finally a boot that is rugged, comfortable and fashionable! I'll get all the colors, but as for the grey, it's a must have for any wardrobe! Once you get the grey, you'll wonder how ever got dressed without them.
Date published: 2019-12-25
Rated 2 out of 5 by PinCLE from Disappointed in the ELK color!!! Truly, this is a quality boot. However, it looks NOTHING like the picture. The picture shows a shiny, caramel colored leather. Different from the matte look of the other colors in this style. In real life it is a dull brown, more like the Bruno color. Not shiny, and uneven in tone. More of a worn work boot look. I wish I could include my own photo for comparison. SO DISAPPOINTING, will return.
Date published: 2019-12-14
Rated 2 out of 5 by stuff343534 from Sole coming apart Should have listened to the reviews that complained about the sole coming off. Mine is also starting to come off, thankfully it was within a year so I returned them. Other than that, they are actually very comfortable. But a shoe sole should not come apart in less than a year.
Date published: 2019-12-12
Rated 5 out of 5 by Andrew19 from Great boots Great looking, comfortable boots.
Date published: 2019-11-27
Rated 5 out of 5 by Sarahlhi from still looks brand new! I bought these for my husband a couple years ago. He has worn them all through our rough, icy winters. Going into their 3rd winter they still look new. I just saw the new colors and will be purchasing another pair for him. I hope the quality is the same as it was a couple years ago.
Date published: 2019-11-14
Rated 5 out of 5 by DaniB89 from Best Boots Ever I purchased these for my husband for Christmas, and somehow he's already wearing them! They are perfect for the cold months and look clean and crisp with jeans and even his work pants. Five star rating from us!
Date published: 2019-11-13
Rated 4 out of 5 by HeberHC from Beautiful boots light to medium duty I bought the Major, Buffalo color in a size 10. I got this for my winter eurotrip. I needed a pair of shoes that I could use in a daily basis, for my long walks during the day, sightseeing or touring, and to go out to a bar or a restaurant without looking too informal or like a hiker. I traveled for a month and a half, and every day I walked A LOT, over different surfaces, mostly over stone and concrete, but in a couple of ocasions over muddy terrain. PROS: This pair turned out to be really comfortable and warm (using good wool socks), and for the most part they were really waterproof. No water filtering within the seams or anything. They looked really good (they still do) and I keep getting compliments for them. After a one year use they look cool, with more personality. CONS: The grip of the sole is not great, in wet surfaces they are really slippery (rain or snow), I almost fell walking in a wet cobble stone road. And another big con was that one of the soles started to get detached from the front of the shoe (the toe area). It's not completly loose, it's just a small part, but it makes the shoe look worn out. In conclusion, I love this shoe, and I would highly recommend it.
Date published: 2019-08-12
Rated 5 out of 5 by Lucky1957 from Madson Boots These boots are great!! I have 4 pairs. They are very comfortable and stylish. what I like best is selection of different colors you can get these boots in. I work for a non profit in a office setting, and these boots are stylish enough for me to waer. If you like the work boot look!! These are the boots to get..
Date published: 2019-07-21
Rated 5 out of 5 by mountain7goat from Great boot! This boot is very comfortable, very little break in time needed and it is truly an ALL day wear. Supports the foot excellent and the waterproof feature is great. Love the style and pairs well dressed up or down pending he occasion. I am getting many compliments on it. I recommend this product but would suggest that you size down 1/2 size from your regular order. I wear an 11 and had to exchange for 10.5 Thanks Sorel for great customer svc and boot - love it!
Date published: 2019-06-10
Rated 5 out of 5 by YourWriterSheila from These are the new favorite boots! Bought these in the buffalo color. They look grayish in the ad but are more brown tone. Super comfortable! And...he loves them!
Date published: 2019-06-02
Rated 5 out of 5 by Marcelo from Most comfortable boots ever! I love Solrel's shoes. I have another pair for almost 7 years and they are indestructible but they are also really comfortable.
Date published: 2019-02-18
Rated 3 out of 5 by levee from Love the boot BUT... Love the look and feel of this boot. However, the sole wore out near the toe very quick. Received these for Christmas and returned them Feb 1st with the sole on both boots coming off near the big toe. Live in Chicago and probably wore these almost daily to/from work for about a month. Noticed the wear on the sole within a few weeks.
Date published: 2019-02-02
Rated 5 out of 5 by Old hiker dude from Great boot Love them! Go anywhere boot. Look good enough for the office and rugged enough for the woods. Waterproof too.
Date published: 2019-01-08
Rated 4 out of 5 by Monoj from Nice boots So far so good. Very light and comfortable. Just be sure you don't wholeheartedly rely on DSG's website photo as what you may be getting. I did and turns out I received the nubuck leather version as opposed to the full grain leather version in the photo. Still liked them enough to keep but wasnt exactly what I wanted.
Date published: 2018-11-20
Rated 2 out of 5 by walksalot from Look great, caused me pain I really wanted to wear these boots, they look great, they're nice and wide, waterproof, and they were comfortable in the store. But after a day of walking around they became quite painful. The back of the boot on the inside is very hard and caused the back of my heel pain with every step, never had a shoe do that before.
Date published: 2018-10-21
Rated 2 out of 5 by Andy from Poor quality I purchased these boots in February of this year based on the product reputation and that they were waterproof. Now in October, the soles are beginning to separate/split! Extremely disappointed!!!
Date published: 2018-10-17
Rated 5 out of 5 by leftyhefty from amazing boots for everyday wear or for a day hikin have had these boots almost two years now and love them still. fully waterproof and if you manage to get them wet by sinking your foot while hiking they dry faster than any boot I've owned. I took them on a 35 mile boundary waters trip this year and they were the best boots I've ever taken. plus you can wear them around town and still look good.
Date published: 2018-10-04
Rated 4 out of 5 by ChrisSwede from Great Dress/Casual Boot I've wanted to buy Sorel boots for a while but was always a little hesitant due to the higher prices. I can say now that these boots are worth every penny! They are comfortable, durable, and very fashionable. I feel comfortable wearing them out to the bars and also to work on snowy days. It's nice to have a material that is resistant to moisture and doesn't deteriorate, I have a feeling that this pair will be around for a while.
Date published: 2018-05-12
Rated 5 out of 5 by Ty805 from Madson Moc Toe I bought these before traveling to Ireland. While using them on the journey they are more than comfortable with well used grip for traction in mud and on rock surfaces. The leather keeps your feet warm and dry as well as protected from stubbing objects. They function just as well on the streets as they do in the wilderness with a sharp and modern design.
Date published: 2018-03-29
Rated 5 out of 5 by Willl from Bruno, Black Color In construction, and this is the most comfortable boot I've ever worn. Stylish, rugged, waterproof and feels great! I highly recommend these!!
Date published: 2018-03-14
Rated 1 out of 5 by Quote from Boots are great, but laces frayed within 30 days The boots are good looking, reasonably tough, and very comfortable. Within the first month of ownership the laces on both boots frayed an broke. I figured Sorel's warranty would cover this but they refused to replace them. Overall, good boots, but the warranty and laces are lacking for something marketed as "rugged".
Date published: 2018-03-06
Rated 1 out of 5 by Quote Brace from Shoes are great, but laces frayed within 30 days The boots are good looking, reasonably tough, and very comfortable. Within the first month of ownership the laces on both boots frayed an broke. C'est la vie, I figured Sorel's warranty would cover this. No such luck. Overall, good boots, but the warranty is lacking for something marketed as "rugged".
Date published: 2018-03-06
Rated 5 out of 5 by Almondguy from Love These Boots Bought the first pair in the dark brown and loved them so much I ordered another pair in black. I wear these all day and they are very comfortable. My only complaint is you are sold out of the dark brown as I like these so much I want a back up pair.
Date published: 2018-02-17
Rated 1 out of 5 by JessRDH from Different widths, same shoe size I LOVE the way these shoes look but unfortunately the pair I bought my husband is defective. One pair is 1/2 inch wider than the other. They are labeled as the same size, so we are a little confused. Usually Sorel has such high quality. We were sadly disappointed. He can't wear them and it is past the date for return :( If anyone wants a pair of shoes that are different widths, please let me know! I'll be glad to get them off my hands.
Date published: 2018-02-09
Rated 3 out of 5 by raimtony from Solid Boot, Needs More Durablilty I ordered the Madson Moc-Toe Waterproof Boot. The boot was slightly oversized. I typically wear thicker socks in the winter so it wasn't a deal breaker. The handful of times I wore the boot it was great, they looked amazing and felt good on my feet. However, the rubber soles started to peel from the toe of boot. The toe of the rubber soles would scrap against the pavement making it a nuisance to walk. I returned them and plan on giving the boot another shot because I really did like the comfort and look of them. I would have given a better rating if the boots were more durable.
Date published: 2018-01-30
Rated 4 out of 5 by KD1008 from Nice boots! Great boots -- great for everyday wear!
Date published: 2018-01-21
Rated 1 out of 5 by mgreenagain from Love The Look but not impressed with the quality I bought these boots they look great dress up and down great for work or for everyday use. They are pretty comfy for the most part,but as soon as a started wearing them I started getting foot and ankle fatigue. To me that was not a deal breaker could just be part the the break in process. Then 2 weeks after I bought them the sole of the boot started separating from the boot. For me this is unacceptable especially because I forked out 180 dollars on them. Maybe it was just bad luck but I am taking them back and I wont be getting another pair.
Date published: 2018-01-18
Rated 5 out of 5 by Isaac from They Grew on Me I have enjoyed using these boots. At first, I didn't like the color, but they are comfortable and warm. They are also silent when one walks in them which is weird for boots. I will likely buy this brand of shoes again.
Date published: 2018-01-17
Rated 2 out of 5 by jalo33 from Coming Apart I purchased two pair of this boot, the black and the brown. The black sole began tearing away after only a couple months. Emailed SOREL on December 2nd with a warranty claim (W1712021433D2) Only received an auto responder with claim number. Have yet to hear back from them. You would think a $200 boot would last more than 2-3 months before it starts to fall apart. The brown pair are now beginning to come apart as well.
Date published: 2018-01-17
Rated 5 out of 5 by Lmcsas from Sorel boots Love them for everyday boots but not warm in cold temps..
Date published: 2018-01-17
Rated 1 out of 5 by Therabitier from Toe of Sole Unglued, No Fix Was wearing these boots inside with all tags on them for 2 days to make sure I liked the fit. Sole of boot came unglued to stitching during this time. Called to set up a return, no more in color/size, warranty can't help until your out of the 60 day return period, they don't fix things like this, only option if I wanted to keep is to pay to go to boot repair myself and void warranty in process (no they do not allow anyone else to work on their boots). Second pair of Sorels and possibly my last. My other snow boots I bought 3 years ago (Only wear to drive to mountain for boarding really) are going in for shoe glue repair out of my pocket as well on $200 boots. When I am off work, I will upload picture of toe with tags attached still.
Date published: 2018-01-04
Rated 5 out of 5 by LindaS from Stylish and functional I bought these as a Christmas gift for my husband and he loves them. They're perfect for the cold Chicago winter and he can go out in them and look stylish. They are the perfect winter boot!
Date published: 2018-01-02
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text:
House Hunting Real Estate Apps
If you're looking for a new home this season, why not start your search from the comfort of your living room couch?
Thanks to the many real estate apps and websites, searching for a new home in 2019 is worlds away from what it was just a couple decades back. You can
Category: Home Ownership

subset: commoncrawl


text:
appbase-js is a universal JavaScript client library for working with the appbase.io database.
It can:
- Index new documents or update / delete existing ones.
- Stream updates to documents, queries or filters over
- Work universally on Node.JS, Browser, and React Native.
It can't:
- Configure mappings, change analyzers, or capture snapshots. All these are provided by elasticsearch.js - the official Elasticsearch JS client library.
Appbase.io - the database service is opinionated about cluster setup and hence doesn't support the Elasticsearch devops APIs. See rest.appbase.io for a full reference on the supported APIs.
This is a quick start guide to whet the appetite with the possibilities of data streams.
Creating an App
Log in to appbase.io dashboard, and create a new app.
For this tutorial, we will use an app called
newstreamingapp. The credentials for this app are
appbase.io uses HTTP Basic Auth, a widely used protocol for a username:password based authentication.
Install appbase-js
We will fetch and install the appbase-js lib using npm.
4.0.0-beta is the most current version.
npm install appbase-js
Adding it in the browser should be a one line script addition.
<script defer src="https://unpkg.com/appbase-js/dist/appbase-js.umd.min.js"></script>
Alternatively, a UMD build of the library can be used directly from jsDelivr.
To write data or stream updates from appbase.io, we need to first create a reference object. We do this by passing the appbase.io API URL, app name, and credentials into the
Appbase constructor:
var appbaseRef = Appbase({
url: 'https://scalr.api.appbase.io',
app: 'newstreamingapp',
credentials: 'meqRf8KJC:65cc161a-22ad-40c5-aaaf-5c082d5dcfda',
var appbaseRef = Appbase({
url: 'https://meqRf8KJC:email@example.com',
app: 'newstreamingapp',
Credentials can also be directly passed as a part of the API URL.
Storing Data
Once we have the reference object (called
appbaseRef in this tutorial), we can insert any JSON object into it with the
index() method.
var jsonObject = {
department_name: 'Books',
department_name_analyzed: 'Books',
department_id: 1,
name: 'A Fake Book on Network Routing',
price: 5595,
type: 'books',
id: 'X1',
body: jsonObject,
.then(function(response) {
.catch(function(error) {
type: 'books' indicate the collection (or table) inside which the data will be stored and the
id: '1' is an optional unique identifier.
index() method (and all the other
appbase methods except streaming methods) return a promise.
appbase.io uses the same APIs and data modeling conventions as Elasticsearch. A type is equivalent to a collection in MongoDB or a table in SQL, and a document is similar to the document in MongoDB and equivalent to a row in SQL.
GETing or Streaming Data
Unlike typical databases that support GET operations (or Read) for fetching data and queries, Appbase.io operates on both GET and stream modes.
Getting a Document Back
Now that we are able to store data, let's try to get the data back from appbase.io with the
get() method.
type: "books",
id: "X1"
}).then(function(response) {
}).catch(function(error) {
/* get() response */
"_index": "newstreamingapp",
"_type": "books",
"_id": "X1",
"_version": 5,
"found": true,
"_source": {
"department_name": "Books",
"department_name_analyzed": "Books",
"department_id": 1,
"name": "A Fake Book on Network Routing",
"price": 5595
Even though
get() returns a single document data, appbase.io returns it as a stream object with the 'data' event handler.
Subscribing to a Document Stream
Let's say that we are interested in subscribing to all the state changes that happen on a document. Here, we would use the
getStream() method over
get(), which keeps returning new changes made to the document.
type: 'books',
id: 'X1',
function(response) {
console.log('new document update: ', response);
function(error) {
console.log('getStream() failed with: ', error);
Don't be surprised if you don't see anything printed,
getStream() only returns when new updates are made to the document.
Observe the updates in realtime
Let's see live updates in action. We will modify the book price in our original
jsonObject variable from 5595 to 6034 and apply
index() again.
For brevity, we will not show the
index() operation here.
/* getStream() response */
"_type": "books",
"_id": "X1",
"_source": {
"department_id": 1,
"department_name": "Books",
"department_name_analyzed": "Books",
"name": "A Fake Book on Network Routing",
"price": 6034
In the new document update, we can see the price change (5595 -> 6034) being reflected. Subsequent changes will be streamed as JSON objects.
Note: Appbase always streams the final state of an object, and not the diff b/w the old state and the new state. You can compute diffs on the client side by persisting the state using a composition of (_type, _id) fields.
Streaming Rich Queries
Streaming document updates are great for building messaging systems or notification feeds on individual objects. What if we were interested in continuously listening to a broader set of data changes? The
searchStream() method scratches this itch perfectly.
In the example below, we will see it in action with a
match_all query that returns any time a new document is added to the type 'books' or when any of the existing documents are modified.
type: "books",
body: {
query: {
match_all: {}
}, function(response) {
console.log("searchStream(), new match: ", response);
}, function(error) {
console.log("caught a searchStream() error: ", error)
/* Response when a new data matches */
"_type": "books",
"_id": "X1",
"_version": 5,
"found": true,
"_source": {
"department_name": "Books",
"department_name_analyzed": "Books",
"department_id": 1,
"name": "A Fake Book on Network Routing",
"price": 6034
Note: Like
searchStream() subscribes to the new matches. For fetching existing search results, check out
v0.10.0 introduces a new method
searchStreamToURL() that streams results directly to a URL instead of streaming back.
In this tutorial, we have learnt how to index new data and stream both individual data and results of an expressive query.


text:
Here is the information focusing on miRNAs as biomarkers in the pediatric population with an emphasis on cardiovascular diseases.
MicroRNAs (miRNAs, miRs) are abundant small noncoding RNAs that function post-transcriptionally by negatively regulating the expression of messenger RNAs (mRNAs) via transcript degradation or translational repression. miRNAs modulate gene expression by targeting reverse complementary 6–8 nucleotide "seed" sequences, most frequently located within the 3′ untranslated regions (3′UTR) of mRNAs.
As a vital component of gene regulation, miRNAs can target the expression of a wide variety of genes in various cell and tissue types, and it is estimated that more than 60% of the human genome is subject to their regulation.
A number of different miRNAs are expressed in different cell and tissue types, and multiple roles for miRNAs in the regulation of various biological and disease processes have recently been elucidated.
Additionally, while many miRNAs are located within cells, miRNAs are also often found in the extracellular environment. Cell-free or circulating miRNAs have been stably detected in both plasma and serum, and studies have shown that these extracellular miRNAs exist not only through cell lysis, but also via active secretion.
The integrity and stability of endogenous circulating miRNAs can be explained via their interaction with and/or packaging within other secretory particles, protecting them from ribonuclease degradation.
Argonaute-2 (Ago-2), a key effector protein, for example, has been shown to be a miRNA carrier in peripheral blood, and high-density lipoproteins (HDLs) have been shown to participate in the transport and delivery of miRNAs in human plasma. Moreover, circulating miRNAs can be stably transported within extracellular vesicles, including inside apoptotic bodies, microvesicles and exosomes. In particular, vesicles such as exosomes have important roles in cell to cell communication, and miRNAs, along with other cargo, can be selectively packaged and transported specifically to recipient cells.
Pathophysiologic changes in the progression to heart failure often occur prior to the clinical presentation of symptoms, however, many existing biomarkers for these pathologic changes have not been validated in children. Thus, it remains critical for new clinical biomarkers in pediatric heart failure patients to focus on: better understanding the pathophysiology of the disease, informing treatment decisions, and/or predicting outcomes.
Importantly, diagnostic and prognostic miRNA disease biomarkers can lead to the early subclinical detection of cardiotoxic or pathological changes, which can lead to early intervention, and in some cases to a reversal of pathologic changes. While pediatric specific biomarker studies relevant to clinical cardiology remain limited, over the past several years, a number of promising pediatric studies have been conducted.
Recent studies have also investigated circulating miRNA levels in association with congenital heart defects. Ramachandran et al. showed an inverse correlation between the levels of miR-129-5p in circulating microvesicles of patients with single ventricle physiology, and the likelihood these patients will eventually develop heart failure.
Another study showed that differential expression of four miRNAs (miRNAs-19b, miR-22, miR29c and miR-375) in the serum of pregnant women were highly predictive of the presence of fetal congenital heart defects.
Interestingly, miR-29 (29b) and miR-499 expression was elevated in patients with cardiomyocyte injury post anthracycline treatment, suggesting circulating miR-29 is associated with cardiac defect/injury.
Similarly, miR-499, miR208a and miR-208b (the so called MyomiRs due to their co-localization with muscle-specific genes) expression was highly up-regulated in pediatric patients post open heart surgery, and their expression was associated with delayed recovery and/or known markers of cardiac injury . Although the number of patients used in these studies is relatively small, the common dysregulation of these miRNAs support their association with cardiac-related congenital defects.
The growing childhood obesity epidemic contributes to increased morbidity and mortality in young patients, with a particularly increased risk of developing atherosclerosis, endothelial dysfunction, hypertension, and metabolic syndrome, which ultimately contribute to significant increases in cardiovascular dysfunction.
Importantly, miR-125a-5p, miR-342-3p, and miR-365b-3p, have been identified as potential diagnostic biomarkers of endothelial dysfunction in pediatric patients, and their common predicted mRNA target genes are involved in transforming growth factor-β signaling, cytokine-cytokine receptor interactions, and activin receptor-like kinase in cardiac myocytes, suggesting plasma miRNAs may be useful screening tools for the presence of endothelial dysfunction in children prior to the onset of cardiovascular complications.
More recently, Circulating miR-663 was shown as a useful classifier for vascular responsiveness to acute oxygen and inhaled nitrous oxide challenges in pediatric pulmonary arterial hypertension (PAH) subjects, suggesting that circulating miRNAs correlate with vascular function in these patients
Future studies and increased patient numbers will likely find ways to mitigate these problems as the miRNA biomarker field continues to grow.
C.C. Sucharov et al. Progress in Pediatric Cardiology 49 (2018) 50–52
Friedman RC, Farh KK-H, Burge CB, Bartel DP. Most mammalian mRNAs are conserved targets of microRNAs. Genome Res 2009;19:92–105. doi:https://doi.org/10. 1101/gr.082701.108.
Mitchell PS, Parkin RK, Kroh EM, Fritz BR, Wyman SK, Pogosova-Agadjanyan EL, et al. Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci U S A 2008;105:10513–8. http://dx.doi.org/10.1073/pnas. 0804549105.
Kosaka N, Iguchi H, Yoshioka Y, Takeshita F, Matsuki Y, Ochiya T. Secretory mechanisms and intercellular transfer of microRNAs in living cells. J Biol Chem 2010;285:17442–52. http://dx.doi.org/10.1074/jbc.M110.107821.


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Thoughts on British ICT, energy & environment, cloud computing and security from Memset's MD
We just watched the first two parts of Atlas Shrugged. I was unfamiliar with Ayn Rand and her works until today. I found the films exhilarating and eagerly await the third installment.
They depict a near-future world where economic collapse and enduring recession has enabled politicians to seize increasing power over private individuals and corporations. In the name of "the greater good", they effectively outlaw competition and and ultimately appropriate intellectual property. Against this backdrop, increasing numbers of value-creating entrepreneurs as well as other talented individuals (eg. composers) are going missing.
A few years ago I would have thought Rand's dystopia future unrealistic, but with the recent turbulence I now doubt that our economic system is sustainable. I see two main reasons for this:
1) We are at the dawn of the post-labor economy. Machines now do most menial jobs better than people can, and as a result there are simply not enough jobs to go around. The welfare state bloats while the increasing-few whose talents cannot yet be automated bear the burden.
2) There is now an alternative financial and information system which is outside the reach of our inept governments: cryptocurrencies (eg. Bitcoin, Litecoin and their brethren) and cipherspace.
As the governments of the world tighten their grip around those of us who drive progress and create value, we will increasingly turn to the crypto-economy. My friend Simon Wardley, an economics advisor to the Cabinet Office, agrees.
Of course, governments can ultimately exert physical force over their citizens. That is where the Atlas Shrugged concept becomes really interesting, since what will the intelligent and capable do before the feds come knocking with warrants to force us to relinquish our wealth or be imprisoned?
We will leave.


text: Sometimes in life you get lucky enough to be offered second chances at happiness. Don't look away from these chances because, though they hit like a ton of bricks, it knocks you down in the best of ways. Lucas Peterson, you are the best thing that happened to me for unquantifiable reasons. Thanks for letting me be a your feminist wife. Thanks for being a feminist husband. Thanks for being a kind heart and a thoughtful mind with an artist's soul. Thanks for being an amazing dad to a daughter whom I know will grow to love and respect you.The first year of marriage was riddled with changes - travels, pregnancy, our daughter's arrival, moving, changing jobs...I could not imagine doing these things with anyone else. We may live by our own set of rules, but that's what makes us uniquely us. When I drown out the noise and distractions that so often define our days, I am joyful in your company, humbled by your kindness and amazed by your talent. Thank you wholeheartedly for choosing to do life with me. I can't wait to enjoy all the rest of the anniversaries with you!


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4W GU10 LED Spotlight Bulbs Cast Iron Shell Energy Saving Lights
Displaying 1 to 8 (of 8 reviews)
Date Added: 08/16/2018 by Alan Ramsdale
thanks for great service and product. free shipping sells 5*****
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Excellent service and fantastic after sales support
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As described, fast shipping, well packed ... A+++ Seller
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Until now they seemed good value and good quality but one of them has just failed after 4 months of ...
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Excellent price and really bright LED lights with high Lumens and low Wattage.
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Just used these for first time. Much brighter than the halogen bulbs they replace but they run cool ...
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Bought two of these in October last year, and both have now failed. So, nowhere near the 50000 hours...
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I ordered two packs, 11 out of 12 in the packs worked, one didn't. Nice bulbs though, not too chunky...
Displaying 1 to 8 (of 8 reviews)


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Education Programs Young Artist Profiles
Previous | Next
What programs were you in and what was your impression of them?
Saturday Studios and jumpstART. These programs were great because I was able to learn a lot about art and develop my skills as an artist so I can apply them in my future career.
What influenced you most while in the program?
The thing that influenced me was the cool projects we had the opportunity to work on. There were certain things I wasn't able to do either at home or at school that Joan Mitchell Foundation's programs allowed me to do and be creative.
What was most challenging?
What was most challenging was doing the kinds of things I don't normally do in my art and types of things I am not used to. At the time it was drawing for me, because I was always into building and sculpting.
What advice can you give to other young artists?
You can be whatever you want. If you focus on that and work hard you will be able to accomplish that.
What artists are most important to you?
Ryan and Trevor Oakes and Alex Gavryushenko are my favorite artisst and most important to me, because the both do something different with their art work that others don't: they experiment a lot. Ryan and Trevor Oakes are twins, who make these really cool panoramic frames and drawings, giving the illusion that you are there. But my favorite is Alex Gavryushenko, in addition to doing wood panels and prints, he makes toys, and applies his knowledge of screenprinting to his toys.
What are your goals for your future in art?
Right now, I am accomplishing my dream to becoming a toy designer. I am a toy design student at FIT. My goal is to graduate the program and work in the industry making toys and improve my skills as an artist and designer.
What would you say to a young person considering a Joan Mitchell Foundation art program?
I would say to who ever is considering a Joan Mitchell Foundation art program is that their programs allow me and everyone else to meet people, make art with resources I wasn't able to get and be creative. Without their help I don't know where I would be today, just like they helped me to follow my dreams they will do the same for you.
Joseph is attending Fashion Institute of Technology, and is in his junior year working towards a BFA in Toy Design. During the summer of 2015, Joseph will be interning at K'Nex toys, moving towards his career goal as a toy designer.


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Burst pipe? Boiler breakdown? Blown fuse? It's all in a day's work for the experienced plumbers at Plumbline in Enfield. Whether your emergency stems from your plumbing, heating or electrics, you can rely on our team for a professional service at competitive prices.
When something goes wrong in your home, it's important to you that the issue is resolved fast. At Plumbline, we've been providing Enfield, North London and surrounding areas with swift plumbing and electrical repairs for over 30 years.
Your emergency is our business, so if you need us, please don't hesitate to call.
Established for over 30 years
Specialists in emergency call outs
Available 24/7
No call out charge
All major credit cards accepted
Which? Trusted Trader & Gas Safe-registered
Licensed member of the Association of Plumbing and Heating Contractors Limited


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Ross is the company's Head Driver and one of the Managing Directors. He is responsible for all driver training, safety and maintenance of the boats and equipment.
Fiona is usually one of the first faces to greet you at the office and is well known as the babysitter of people's dogs and children. She is responsible for the smooth running of the business, key account management and keeping the lads in line.
Will has been with us here at Katoa for several years and has worked his way through the ranks to become our Operations Manager. He is responsible for making sure we can deliver a safe and enjoyable experience to all of our visitors. You will still see him out and about in the Jet Boats and head Skipper of our Water Taxi.
Famously born in a jet boat, Nick is a top driver with a passion for making every trip an unforgettable one.
Not only is John the first Chinese person to obtain a commercial jet boat license in New Zealand, but he is also a pretty awesome parasailing deckhand and Chinese salesperson.
Jaymz is one of our jet boat drivers here at Katoa. When he is not thrilling our customers blasting around Lake Rotorua you will also find him hanging off the parachute as a safety instructor on our Parasailing boat.
History. Adrenaline. Native wildlife. Untouched beauty. All encompases Katoa Lake Rotorua and is waiting for you to discover on Lake Rotorua and Mokoia Island. Whether it's the thrill of jet boating, learning about Mokoia Island's ancient history, or cruising through the crater lake; you'll be amazed and captivated by the history, wildlife, and thrills on and off the water.
In the beginning, we were known as Kawarau Jet, born from Kawarau Jet in Queenstown, the world's first commercial jet boat operation. With such a successful history, it was decided to bring the same experience to the North Island's cultural and adventure capital, Rotorua. As time went on, business owner and operators Ross and Fiona Kelly saw that there was so much more potential than only the excitement and adrenaline of jet boating and chose to build on the jetboating to become Katoa (entirely) Lake Rotorua.
Purpose built Jet Boat made by Mackraft Marine specifically for the conditions on Lake Rotorua. The boat runs a 350 Mercruiser V8 Chev Motor with a Hamilton 212 Jet Unit and is surveyed for up to 11 people.
This is the newest boat in the fleet with its sleek design turning heads whenever it hits the water. It is running an experimental motor based on an XR6 Turbo Engine. Once the Research and Development is complete it will have twin engines, making it one of the fastest commercial jet boats in the country. This boat is surveyed for up to 18 people. It too was designed and built specifically for use on Lake Rotorua.
This is the "Big Boy" of the fleet and runs two Kodiak Marine Chev 350 V8's coupled by twin Hamilton 212 Jet Units. This is built by Mackraft Marine and was the very first "Twin" Engine Commercial Jet Boat to be developed. It is surveyed for up to 28 people and has a top speed of 85km per hour.
This is a purpose built vessel running two Yamaha 150 horsepower outboard engines. You will take off and land on the boat so no water contact or previous experience is necessary. All harnesses, parachutes and associated equipment is certified to the highest standards and regularly assessed and maintained.
This purpose built Commercial Catamaran is perfect for the conditions here on Lake Rotorua. Our water taxi is designed with comfort in mind. It keeps you away from the spray and quickly transports you to Mokoia Island and other locations. With covered seating for up to 30 guests and large windows to take in the scenery this is your ideal transport around Lake Rotorua. It is powered by Twin 300hp Suzuki Outboards making it powerful and quiet.
All boats are equipped with extensive safety equipment, radios and onboard safety mechanisms to ensure your protection against all possible scenarios.
All customers are supplied with spray jackets to keep you warm and dry and lifejackets for your safety. You MUST wear a lifejacket. Spray jackets are optional but highly recommended, especially in the winter months.


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Press Conference on Harmful to Minors held April 25, 2002 by Concerned Women for American at the National Press Club. Statement by Robert Knight concerning Harmful to Minors: The Perils of Protecting Children from Sex by Judith Levine (University of Minnesota Press, 2002)
If this were just about one book, we wouldn't be holding this press conference.
But Harmful to Minors is more than just a bizarre decision by the University of Minnesota Press, perhaps to achieve notoriety by any means. Judith Levine's opus is the logical product of a culture that has been softened up to accept the abnormal as normal, and to push the normal into a box labeled "narrow" or "intolerant."
We are now being told that protecting children from early sexual exposure is a form of tyranny. We hear children described as "sexual beings," as if sexual activity were the defining characteristic of their young lives.
Always, the mantra is that "science" has made religious taboos obsolete. "Science" shows us that children are sexual from birth, capable of sexual response and therefore available as sexual partners. "Science" tells us that religion is bad, because it represses natural sexual expression, especially that of children.
This view, argued on the fringe by pedophile authors over the past century, gained enormous respect when Alfred C. Kinsey published his books on male and female sexuality in 1948 and 1953, known collectively as the Kinsey Report.
Kinsey's books redefined sexual normalcy and painted a picture of Americans awash in sexual activity of all kinds. Kinsey's Sexual Behavior in the Human Male provided the scientific backing for the now-discredited assertion that 10 percent of the population is homosexual.
Thanks largely to the work of Dr. Judith Reisman, who co-authored the books Kinsey, Sex and Fraud in 1990 and Kinsey: Crimes and Consequences in 1998, Kinsey was unmasked as a charlatan. A biography by Kinsey insider James Jones in 1997 titled Kinsey: A Public/Private Life revealed that far from being a conservative husband and father, as the media had portrayed him, Kinsey was a homosexual sexaholic who favored sadistic practices, some of which may have contributed to his death.
Kinsey worked to lower penalties for sex offenders, and said he couldn't understand why children were harmed by being sexually touched by adults. He based this on a series of sex experiments on children as young as 2 months of age. A chapter in Sexual Behavior in the Human Male reports on the molestation of hundreds of boys, with Kinsey concluding that the victims enjoyed the activity. The Family Research Council documentary The Children of Table 34 illustrates the extent of Kinsey's criminal activities involving children and its effects on sexology, sex education and American culture.
Kinsey and his disciples began to evangelize for child sexuality. His co-author, Wardell Pomeroy, helped found the Sex Information and Education Council of the United States, which even today promulgates the Kinsey view that children of all ages are entitled to sex. Pomeroy has promoted not only child sex but has endorsed incest as well.
Kinsey's close associate, Mary Calderone, who was Medical Director of Planned Parenthood and was SIECUS's first president, described SIECUS' mission as educating America with the "awareness of the vital importance of infant and childhood sexuality."
Other Kinsey disciples went on to write the Model Penal Code, which has guided many states to reduce penalties for sex offenders. Kinsey remains the most often-cited sex authority in court cases, with literally thousands of references.
As for education, the Kinsey model of child sexuality, based entirely on criminal and fraudulent research, is the guiding principle behind much of what passes for sex education today, and it is the spirit behind Harmful to Minors.
In Harmful to Minors, Miss Levine makes only a passing reference to Kinsey (they are learning to cover their tracks), but speaks glowingly of SIECUS, Planned Parenthood and various pedophilic authors that reflect the Kinsey view of sex.
The Kinsey view is that all sex is merely an "outlet" and that children are "sexual beings" who deserve sexual autonomy. Kinsey dismissed the Biblical view of marriage as an old superstition, and says that all sex is good, at any age, providing consent is given. He even endorsed sex with animals, although it is hard to discern where consent plays much of a role. PETA, are you listening?
Levine's book, which mocks religious tradition and promotes the "progressive" Kinsey view of sex, is a seemingly radical statement, but the basic elements of this view can be found in most sex education curricula, since they are based on the Kinsey model.
If Americans understood the radical roots of the sex education courses in their schools, they would be reaching for abstinence-based curricula as a literal life preserver even faster than they are now. Abstinence courses are gaining rapidly because they work, and because they place sex in context, as a wonderful and important part of a larger view of life.
The Planned Parenthood/SIECUS approach to sex education, endorsed by Miss Levine, has wreaked havoc on America, with millions of unwanted pregnancies, millions of abortions, and millions of cases of sexually transmitted diseases. In the 1950s, health authorities had to deal with two sexually transmitted diseases – syphilis and gonorrhea. Today, they are dealing with more than 25, including Human Papillomavirus, chlamydia, new strains of gonorrhea and the incurable HIV. Meanwhile, SIECUS and Planned Parenthood continue to promote sex to younger and younger children, with the promise that they'll be "safe" if they just use condoms. They do not tell the kids that condoms are useless against regionally transmitted sexual diseases such as HPV, which causes 5,000 annual deaths from cervical cancer.
Miss Levine recounts incidents in which authorities overreacted and implicated innocent people with allegations of child sexual abuse. She has a point; some unscrupulous or overzealous child welfare officials have committed gross abuses. False charges of abuse are becoming staples in custody disputes in bitter divorce cases. But this does not justify portraying all protections for children as oppressive.
Children are being sexualized in our culture, from Calvin Klein's deceptively youthful models to Hollywood's non-stop promotion of sex. Dr. Reisman did a study for the U.S. Justice Department that showed men's pornographic magazines like Playboy and Penthouse routinely have featured cartoons and pictorials that portray children in various sexual poses. The New York Times gives respectful reviews of the child pornography of photographer Sally Mann or deranged artist/author Henry Darger.
The Age of Consent is upon us, in which appetite and consent alone are supposed to validate whatever we do. In terms of sex, this has led us to books like Harmful to Minors, which lay the groundwork for a breakdown in cultural barriers against sex with children.
There is no way a child can give meaningful consent to sex; children lack the maturity to understand the lifelong consequences of sexual acts. Those who would make the case that children ought to be available as sex partners are the molesters' best friends.
Next: Timothy Dailey, Ph.D., Family Research Council


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Spyware Extortion
If you pay it one time you will be paying the rest of your life.
It is like something out of the TV show 24, a nasty manipulative computer virus, one that wants you to pay ransom after it strikes your system. It actually holds your PC hostage. Makes you think you have to pay to get your valuables back, but you can beat extortion spyware and David Martin shows you how only on FOX.
Imagine someone taking all the photos, videos, and documents whatever
else you might have in your computer and putting them somewhere in
the vault. Need the key to get them out? How about a credit card number
Welcome to extortion spyware!
You surf on the net, out of nowhere, you get a pop up – the beginning of a bad virus. And the pop up will ask you some mundane questions like do you want us to install whatever and yes or no and both buttons are really yes. And that's a nice version of extortion spyware says Doug Chick, network administrator in Longwood. Here's a nasty version of the virus – porn pictures flanked by a profanity laced message that reads – is this computer valuable? It better not be. It then tells you to wire money through western union to remove it.
Spyware Extortion
It tells you if you don't purchase the removal program for 9.99,
they are gonna start deleting files off your computer every 30 minutes.
The virus got this hard drive even turning it off and on wouldn't
remove the extortion spyware.
Doug quarantined it in his office because the guy who owns it didn't wanna pay the ransom. Good move.
If you pay it one time, you will be paying the rest of your life.
Porn sites, gambling sites, fake virus removal sites, typical places,
where the hijacking virus looks.
Now they appear on unsecured computers 15 minutes out of the box because if a computer sits in a box for three months before they ship it, it doesn't have the update security patches on it. So the moment you plug it into the internet, you are susceptible for these viruses or extortion ware.
Patches stay on top of the security patch updates but if your pc still gets infected which it can, the good news is, its fixable – semantic.com will teach you how to do it. The bad news its difficult so you may have to pay someone to help you out. Back to you.
And David thank you, we are gonna.


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Our feet carry us everywhere, but they may be just about the most neglected part of the body. Fortunately, we have a few genius foot exercises that will change that for the better!
Your feet are actually a great window into the aches and pains that impact other parts of your body. A lot of body pain can radiate down to the feet and cause discomfort in your tootsies.
By the same token, pain that starts in your feet can have a wide-ranging impact on other parts of your body.
In other words, exercises that strengthen your feet and treat their aches and pains can have a profound impact on the health of your entire body.
There's nothing better than a good, old-fashioned workout for helping your feet stay pain free, and helping to solve other aches and pains throughout your muscles and joints.
Scroll through below to learn about the easy foot exercises that you can do right at home to keep your whole body happy.


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The Orange Card is a leading Australian drug education and awareness platform; an online learning tool that is designed to tackle the growing illicit drug problem we are seeing in Australian workforces. The aim of the Card is to first and foremost educate people on the dangers of using these drugs and the impact they have on our workplace and community. With awareness comes the ability to make better choices and spread the word to the wider community – early intervention and education are key. This course has also been developed to keep employers and employees protected.
The innovative team at The Orange Card have developed the course into ten easy modules, designed to get to the point quickly and clearly. The ten areas covered in The Orange Card are: Methamphetamine, Marijuana, Cocaine, Heroin, MDMA, Research Chemicals, 25in BOME, Synthetic Cannabis, Fentanyl, and workplace responsibilities and safety. These drugs are the strongest areas of concern for employers around Australia.
The Orange Card will continuously evolve as new drugs take a grip on Australian workforces and the team will endeavour to keep Australian employees and employers educated and aware.
Benefits to your work
Drug awareness in the workplace is becoming increasingly necessary.
Completing The Orange Card will ensure that you are staying ahead of the pack.
Find out what's in synthetic drugs and where they come from
Learn the impact these drugs can have on your work life, family, community, and your mental/physical health
Improve your resume with formal education in drug awareness
Widen your scope of work opportunities
Ensure your staff are educated on illict drugs with this proactive approach
Spread the word on illicit drug awareness with your family and community once you have completed the course
Are you a contractor?
As more organisations commit to a drug free workplace, contractors and sub-contractors will benefit from the adoption of The Orange Card by proving your commitment to provide a drug free workforce for your clients, and a safer working environment for your employees.
Educate yourself and make a commitment to your clients and employers
by takingThe Orange Card course today.
Or contact us for more information about incorporating
The Orange Card into your workplace. CONTACT US
The Orange Card Proudly Supports Sideffect
Sideffect is an Australian not-for-profit organisation that is dedicated to the early intervention and education of illicit dugs. With a focus on reaching Australian schools with their powerful message, the Sideffect team are also helping parents, regional communities, and at-risk workplaces.
"Our mission is to educate everyone in Australia about illicit drugs (including ICE) – what's in them, what they can do to you, and how they can affect your family and community – so that people are able to make informed decisions based on knowledge and awareness, not misinformation and ignorance." Sideffect team.
Following the death of his beautifully talented and generous son, Preston, Rodney Bridge began Sideffect. Preston died at the age of 16 after taking a synthetic form of LSD which Rod later found out was made up of 25inBome as well as a shopping list of other synthetic drugs. Preston lost his life that night based on one choice and had he known what he was taking, he would have made an entirely different decision. Sideffect was born out of that understanding, that people need to know more about these drugs in order to make informed choices.
Go online to read more about Sideffect and book a visit to your school, community group, or workplace.
The Orange Card training was very well received by our team and apprentices, many of whom said it provided them with a greater understanding of the deadly ingredients used in the production of synthetic substances.
I am pleased to announce that effective as of the 1st February 2018 the Duxton Hotel will officially introduce The Orange Card as part of its compulsory accredited employment check for all of its future employees. I encourage all business leaders to embrace this wonderful initiative and make a difference in the lives of others.


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Officers from the Metropolitan Police attended the gallery yesterday. They are consulting the Crown Prosecution Service over whether the image breaches the Obscene Publications Act.
The provocative picture by New York artist Richard Prince shows Shields standing naked in a bathtub, with a heavily made-up face and oiled torso. Children's campaigners had condemned the Tate for including the picture in their latest exhibition, describing it as a "magnet" for paedophiles.
So controversial is the photograph, called Spiritual America, that it was hung in its own room behind a closed door bearing a warning that the work was "challenging". However, visitors to a preview showing yesterday found the room closed.
The Tate chose to include the picture in the Pop Life: Art In A Material World after consulting lawyers. It has been exhibited in the US before but never in Britain. A spokesman said: "The exhibit is temporarily closed. We are in discussions with police."
A Metropolitan Police spokesman said: "Officers from the Obscene Publications Unit met with staff at the Tate Modern regarding an image. The officers have specialist experience in this field and are keen to work with gallery management to ensure that they do not inadvertently break the law or cause any offence to their visitors."
Prince's work is a photograph of a photograph. The original was taken by Garry Gross, a US photographer, in 1975. It was commissioned by Shields' mother, who was intent on turning her little girl into a child star and signed away the rights. The picture was later featured in a Playboy Press publication, and Gross planned to turn it into a poster.
In 1981, Shields made an unsuccessful attempt to buy back the negatives. A judge ruled that she was a "hapless victim of a contract... to which two grasping adults bound her". The legal battle caught the eye of Prince, and he describes Spiritual America as a commentary on Shields as an "abstract entity"
Children's campaigners criticised the Tate for exhibiting the image. Michele Elliott, founder of Kidscape, said: "Brooke Shields was 10 years old when this picture was taken. She could not have given informed consent to it being used. It must be bordering on child pornography. It is certainly not art.
"If you are using a picture of a naked child to bring people to your exhibition, then you are exploiting that child. It's as if they are using a 10-year-old girl for bait. I find it disturbing and they should be ashamed of themselves. And putting the picture in a room with a warning outside really is a magnet for paedophiles."
In September 2007, Northumbria Police seized a photograph of two naked girls from Gateshead's Baltic gallery. The picture, shot by Nan Goldin and owned by Sir Elton John, was later returned after the Crown Prosecution Service deemed it was not an indecent image.


text: Our company is based on the belief that our customers' needs are of the utmost importance. Our entire team is committed to meeting those needs. As a result, a high percentage of our business is from repeat customers and referrals. We would welcome the opportunity to earn your trust and deliver to you the best service in the industry. Either by designing and decorating your event or by delivering our beautiful Balloon Bouquets to you.


text:
This database includes the information about barley germplasm and barley genome analysis in the Research Institute for Bioresources, Okayama University. The information of barley genome analysis, which has been generated recently, provides updated analytic techniques and new information about barley germplasm.
The image database of naturalized plant seeds in Japan created and maintained by the Group of Wild Plant Science.


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The Glucksman Library, University of Limerick is closed until further notice due to COVID-19.
The Interlibrary Loan (ILL) service will continue to assist you in obtaining electronic material that is not held directly by the library. This service is aimed at:
· Academic staff
· Postgraduate students
· Final year undergraduate students.
University of Limerick's Interlibrary Loans service has temporarily suspended lending printed books. Please note it is not possible to process requests for printed books at this time. We will continue to process requests for electronic copies of e.g. journal articles, book chapters etc., although this service may also be subject to disruption.
Printed library materials received from other institutions should be held, and will continue to be renewed until further notice. Please ignore any overdue notices from the library that may be auto-generated in the meantime.
If you require any additional information regarding the Inter-Library Loan service, please email us: firstname.lastname@example.com
Who can apply and how long does it take?
The following may apply for interlibrary loans:
- Staff.
- Postgraduates (Taught and Research).
- 4th year undergraduate students.
- Items requested from another library are usually available within 7 days of ordering, but it may take longer if the item is not immediately available from the first location contacted.
- All available lending libraries will be checked as part of your request.
- You will receive an email to confirm if we have successfully/unsuccessfully sourced your request.
- It may take up to 2 days to receive electronic items.
- If the item requested cannot be obtained for any reason, we will inform you of this.
How do I apply for an interlibrary loan?
- Before completing an ILL request form, please ensure that the item is not already available in the library, check the Library Search, the A-Z of journals and the Institutional Repository. There is more information on how to search for books and journals articles in the Library from this page
- There may also be an open access version of your item available.
- Please ensure you qualify to access this service
- Applications for inter library loans are made online using ClioWeb. (Note: The Library no longer accepts paper requests for inter library loans).
- When using ClioWeb, first time users must register.
- After requesting a journal article via ClioWeb, a copyright declaration form may be emailed to you, which you must sign.
- You can drop this form into the Library Information Desk in person, or scan and email the form to firstname.lastname@example.com
- You must supply full bibliographic details of the item you want.
- You must also include your name, student/staff ID number and department details.
- Please include as much detail as possible about the item as incomplete or inaccurate information can cause a delay to the process.
How many interlibrary loans can I request?
|Quota of Requests
|No set quota
|Taught Postgraduates
|5 per academic year
|Research Postgraduates
|12 per academic year
|4th year Undergraduates
|3 (in preparation for final year project)
How do I know when my request has arrived?
- Books and photocopies of journal articles received through the interlibrary loan service can be collected from the Library Information Desk.
- All users will receive an email to confirm if we have successfully/unsuccessfully sourced your request.
- Items should be collected as soon as possible after notification is received.
- Items requested from another library are usually available within 7 days of ordering, but it may take longer if the item is not immediately available from the first location contacted.All available lending libraries will be checked as part of your request.
How long can I keep an interlibrary loan Item?
- You can keep photocopies of journal articles.
- The loan period for books is designated by the lending library - this can vary from one to six weeks.
- You can take most items home but some are for use in the library only.
- Items which are designated "For Library Use Only" are held for users at the Library Information Desk and are available for consultation during desk opening hours.
- Your staff/student ID card is required when collecting such items.
- We ask you to respect the conditions of the ILL service with regard to borrowing, recalls and overdue items.
Charges imposed by the British Library for overdue and/or lost items can be very expensive, and these charges will be passed onto the user.
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How to search for Theses from Other Institutions
Dissertations and Theses: UK & Ireland
This is a listing of theses, with abstracts accepted for higher degrees by universities in the United Kingdom and Ireland. Dissertations and Theses: UK & Ireland now incorporates Index to Theses.
ETHoS (Electronic Theses Online Service) from the British Library (full text)
Where a thesis has been digitised previously by the British Library, it may be available to download
for free. In other cases, you may have to request that the British Library digitise the thesis. There
will be a cost and a wait involved.
Where a PDF is available: Login>Click download>Select download>Add to basket>Confirm>Agree to
terms and conditions>Download
DART Europe E-Theses Portal (full text)
Theses from repositories around Europe.
TEL (Théses-en-ligne)
Tel is an initiative of Le CCSD (Centre pour La Communication Scientifique Directe). It aims to provide free access to online versions of Doctoral PHD theses submitted at French Universities and Colleges. All subject Areas of the sciences, social sciences and humanities are covered.
National ETD Portal (South African Theses and Dissertations)
This site is run by the South African National Research Foundation (NRF) in collaboration with Committee of the Higher Education Librarians of South Africa (CHELSA). Metadata for all theses and dissertations produced in South Africa are collected and made accessible, as well as disseminated further, for the site.
Search for thesis only: go to Advanced Search and change content to "Thesis/Dissertations"
Dissertations and Theses A&I
A comprehensive collection of dissertations and theses, with more than 2.3 million doctoral dissertations and master's theses included, covering graduate research from 1861 to present
Google Scholar (citations, abstracts and full text)
Open access repositories are accessible through Google Scholar so you can find theses here. You will have to sort through a lot more results as you cannot limit to "theses".
To distinguish theses from other material, on the result record, where you normally see publication details you will see the name of an Institute or an open access repository.
Institutional Repositories in general
When you know the Institute that awarded the Degree, you could check to see if the institution has an Institutional Repository and then search that for the thesis.
Ireland's national portal for open access to Irish published research provides a single point of access to national research output and contains content harvested from the institutional repositories of Irish academic and research institutions, including the University of Limerick through the ULIR. This includes Masters and Doctoral theses from participating institutions.
Need assistance?
Go to the Library Information Desk on the ground floor to inquire about the Interlibrary Loan service.
The contact person for interlibrary Loan is:
Clare Dwyer
Interlibrary Loan
Glucksman Library
University of Limerick
Telephone : 061 202157
Fax : 061 213090
Email : firstname.lastname@example.com


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Circular 1052-02View PDF picture_as_pdf
This publication is part of the Marriage Matters series.
When the last child leaves home, many couples experience difficulties to this new life adjustment. In this Marriage Matters publication, we offer suggestions on how to identify and describe these problems as a couple and move into the "second half" of marriage.
Status and Revision History
Published on Dec 01, 2013
Published with Full Review on Aug 02, 2016
Ted G. Futris Professor & Extension Specialist, Family & Consumer Sciences


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By now, you've probably heard the news that the Canucks have won the Presidents' Trophy. You've probably also heard some of the subsequent chatter surrounding the merit of the accomplishment. You may have heard, for instance, that this trophy doesn't matter, that only playoff success matters. That is patently false, and you likely heard it from fools.
Rather than explain why, I'll turn things over to Tom Benjamin, who recently debunked the crap out of this crackpot theory:
While there is no doubt that the big prize of any season is the Stanley Cup, its foolish to denigrate other accomplishments in the hockey season, be it the President's Trophy or even a Divisional title. The more we diminish the regular season, the less reason any of us has to watch.
What he said. Regular season accomplishments may not be playoff accomplishments, but they are still noteworthy accomplishments. Ryan Lambert of Puck Daddy argues winning the Presidents' Trophy might even be more impressive than winning the Stanley Cup:
[...] don't get me wrong, I love the playoffs for all the drama that the ping-pong-ball probability brings. But the value placed on them, rather than the regular season, seems far too great to be reasonable. Winning in the playoffs isn't everything. In fact, it's occasionally a complete fluke. You don't get Edmonton/Carolina Cup Finals otherwise.
Yeah, winning the Stanley Cup is a pretty cool accomplishment, and one that should obviously be celebrated to some extent. But to also denigrate beating the hell out of everyone you play for 82 games? That's just stupid. Because winning the Presidents' Trophy is a more impressive achievement.
He might be hyperbolizing slightly, but he's got a point. The Stanley Cup has achieved a level of importance so vast that regular-season accomplishments are, comparatively, worth squat. That's not how it should be. Winning the regular season is a huge deal. Considering that it's technically harder to win than the Stanley Cup, it's silly to pretend it means nothing.
Consider, for example, the Olympics and the World Championships in any sport. The world championships may often be considered the last big tuneup before the Olympics, but nobody scoffs at a world champion just because he or she didn't win an Olympic gold medal. Yes, people place more value on the Olympics, but winning at the World Championships is far from meaningless.
You may have also heard someone espouse the theory behind The Presidents' Trophy curse, a laughable belief that being the winningest regular-season team means a postseason of cuplessness and utter damnation. Jonathan Willis recently debunked the crap out of this crackpot theory:
Okay, so not only does the Presidents' Trophy matter, but it's actually a predictor of success. It is unquestionably worth celebrating, and usually means a pretty decent postseason run is on the horizon.
[Since 1994] the Presidents' Trophy winner [has been] the most successful team, being:
[...] Given that the Presidents' Trophy slot is obviously the most favourable position, why do we create factually vacuous phantoms like the 'Presidents' Trophy Curse?'
- eliminated in the first round the fewest number of times
- eliminated in the second round the fewest number of times
- the Stanley Cup champion more frequently than any other seed
- in the Finals three times as often as the second seed
That said, as soon as the postseason actually starts, it stops mattering.
With that in mind, the Canucks might want to get that banner up lickety-split. The team will be awarded the trophy in a ceremony before their final regular season home game on Thursday, and it would be wisdom to prepare to raise the banner that same day. If they wait until next season, it either goes up alongside a Stanley Cup banner or it goes up without it. If it's the former, no one will care about a Presidents' Trophy banner. If it's the latter, people will just resent it, and we'll be subjected to more silliness about how it doesn't matter.
However, if you raise it on Thursday, there's a possibility that the banner--and the accomplishment it represents--will receive the fanfare it deserves.


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A passion project conceived by a natural wines expert (Karim Hadjadj) and creative natural living enthusiast (Alison Christ), MyHouse is a new QRE Plaza situated wine bar, restaurant and live music venue. Bi-monthly art exhibits from local and international artists make the place a tad trendy, but the house party starts with Resident DJs Arun R and Romi Behl and between them and the local and international DJs and live bands, the music will also have a natural thread with beats ranging from reggae to house music till late.
For those who err more on the side of the introvert (we're into you), there is another secret to this hidey hole; choose an old school vinyl from the shelf, slip it on the individual turntables at each seat, grab the headphones and enter a new world of solemnity with a cup of coffee or a glass of wine and some nibbles. Not hugely social, granted, and perhaps not what the majority of the population envisions Friday night to look like, but if you need solace from the maddening LKF crowd, this is an ideal choice….until the party starts at 11pm.
Opening Hours: (Hours may alter in October)
Lunch: Monday to Saturday, 12pm-3pm
Brunch: Sunday, 12-5pm (from November onwards)
Afternoon break: Monday to Sunday, 3pm-6pm
Dinner: Monday to Sunday, 6pm-11pm
Music Hour: Monday to Sunday, 11pm till late
202 Queen's Road East, 26/F QRE Plaza, Wan Chai
Tel. 2323 1715


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Walking is fast becoming one of the most preferred ways of getting from place to place. In an increasingly hectic world, walking gives people the opportunity to relax, de-stress, and smell the proverbial roses. It is also the one form of transportation that is not directly harmful to the natural environment. Best of all, walking more will improve your health and keep a ton of money in your pocket. When you start shopping for an Irvine home for sale, consider its walk score. Following are several ways that a good walk score can save you money.
Consume Less
When you walk from place to place versus driving, you're far less likely to load up on things that you really don't need. Everything you buy will have to be carried back to your home and thus, living in an area with a good walk score is a great way to avoid impulse purchases and other forms of unnecessary spending.
Stay Fit for Free
You won't need a gym membership when you live in an area with a good walk score. In addition to having access to an exciting array of local shops, you may even find a number of nearby parks, dog parks, and scenic trails (like those Irvine is known for). Walking is a low-impact exercise that is perfect for moderating stress and promoting overall mood balance.
Use Your Car Less Often
A good walk score will also mean far less wear and tear on your vehicle. You'll spend less on gas, maintenance, tires and other forms of automotive upkeep. Keeping your car parked more often can even limit your insurance costs.
Invest in a Property That's Guaranteed to Maintain Its Resale Value
The walk score for a property determines its walkability or how easy it is to access essential resources on foot. This score can range from one to one hundred and properties with scores of 70 or higher are increasingly in demand. As consumers become more frugal, more environmentally concerned, and more fitness-oriented, you can rest assured that your home will appreciate over time and you'll be able to list your house for sale in Irvine for more than you initially paid.
Still searching for your dream home? We can help. At Irvine Residential Living, we specialize in local real estate, matching a client's budget and aesthetics to the neighborhood and home right for them. Check out our inventory of houses, condos, and townhomes for sale in Irvine online or give us a call at (714) 454-6304.


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Tuesday's Tip - Master Source Tip (Intermediate)
April 02, 2019
Tuesday's Tips provide brief how-to's to help you learn to use the Legacy Family Tree software with new tricks and techniques.
Master Source Tip (Intermediate)
In some instances there is a shortcut way to create a new Master Source that will save you some time. In the following example I already have a Master Source for the 1850 census in Columbia County, Georgia. I want to create a new one for Richmond County.
I highlight the Columbia County Source and click Edit over on the right.
All I have to do is change the word Columbia to Richmond in the Source List Name and the Jurisdiction County. Don't forget to change the Source List Name or you will end up with two sources with the same name.
Now over on the right click Save. You will see this screen:
Notice there are TWO options! The first one is when you are truly editing a Master Source and you want to save your changes (overwrite what is there). The second one is the one you will be using in today's scenario. We want to Apply the changes to a NEW copy of this master source. Please be careful here! If you accidentally choose the first option you will overwrite your master source instead of creating a new one.
Now you will see both Master Sources on your Source List.
This is a great time saver but you must be careful!
Find tech tips every day in the Facebook Legacy User Group. The group is free and is available to anyone with a Facebook account.
For video tech tips check out the Legacy Quick Tips page. These short videos will make it easy for you to learn all sort of fun and interesting ways to look at your genealogy research.
Michele Simmons Lewis, CG® is part of the Legacy Family Tree team at MyHeritage. She handles the enhancement suggestions that come in from our users as well as writing for Legacy News. You can usually find her hanging out on the Legacy User Group Facebook page answering questions and posting tips.


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Are you ready?????
I have been invited to join the fabulous and super talented Polka Doodles design team!!!!
How exciting is that???? I am soooooo over the moon and I keep doing a happy POLKA dance!!! Lol; )
I hope you will join me in congratulating all the new recruits and also say "hello" to the "old" team! And maybe at the same time you could also join our new Halloween challenge!
And to celebrate this grand occasion, I am going to share this little shabby beauty with you ;)).
The clock was cut from a recycled cardboard and painted with white acrylic paint mixed with distress re-inker.
And lots of machine stitching and white paint to add to the shabbyness of the card.
I am going off to Poland for a little while so I might not be "around" too often. But I hope you have a lovely weekend and I promise to be back before too long!
Big hugs!!!!


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Even though I've felt like absolute crap for the past couple of days, I did manage to finish another of this year's South Carolina Children's Book Award nominees, Gabriel Finley & the Raven's Riddle by George Hagen. (Only two more to go!)
This book, suitable for upper elementary grade readers on up, is a fantastical tale full of mystery, peril, and riddles. It's a great book for those readers who've exhausted the Harry Potter series and are looking for something similar. And given how this book ended, I'm hopeful that we'll see more of Gabriel Finley and friends in the future.
Gabriel Finley's father, Adam, has been missing for several years. Gabriel lives in Brooklyn with his aunt, but he never stops wondering what happened to his father. Soon, though, Gabriel will begin to solve the riddle of his missing father…and so much more.
When Gabriel discovers that he can communicate with ravens–who are the most intelligent of all the birds–secrets begin to be revealed. As it turns out, his dad shared this gift, and it could have something to do with his disappearance. Gabriel's dad worked with his own raven companion, or amicus, to hide a powerful object from the valravens (cursed, fiendish birds) and their leader, Corax, a being who is half-man, half-valraven…and Gabriel's uncle.
With the help of his own amicus, Paladin, and several friends, Gabriel begins to unravel the truth of what his uncle is seeking and the whereabouts of his father. The journey involves untangling riddles, battle with a magical, music-loving desk, and learning about the Finley family's secrets. Gabriel is determined to find his way to his father, but forces are at work that are equally determined to stop him.
Is Gabriel ready to descend into Aviopolis, Corax's horrifying domain, risking the lives of himself and his friends, to prevent Corax from ruling both above and below the surface? Will he be able to rescue his father, save himself and his friends, and defeat the evil Corax? Read Gabriel Finley & the Raven's Riddle to find out!
I barely touched on my favorite part of this book–the riddles. To a word nerd like myself, they were fun and entertaining, and I loved that saving the world in this book relied more on using one's brain than relying on brawn. I'm hoping my students have as much fun as I did figuring out the answers to the riddles, and I think reading this book could lead to readers crafting their own riddles.
As of right now, there's no word on future Gabriel Finley books, but I'll definitely be on the lookout. There are several mysteries in Gabriel's life that are yet to be solved, and I, for one, would love some answers. In the meantime, if you'd like to learn more about this great fantasy, visit the Gabriel Finley website. Enjoy!


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Why did Blade Runner's product placements feel so organic in 1982 while Blade Runner 2049's placements feel forced and painful in 2017? You can blame Blade Runner.
Blade Runner became a cult classic by asking what it means to be human. But the Ridley Scott film was also influential in the way it imagined the future of brands, pondering what it means to be a consumer-based culture. This vision of commercialization is on display in the new Blade Runner sequel in ways that again transcend typical films.
Until 1982's Blade Runner, Hollywood's imagined future was largely free of the commercial clutter of the modern day. From 1927's Metropolis to 1976's Logan's Run, the future was largely seen as clean and free from obvious branding. Even dystopian films about consumer nightmares like Rollerball envisioned evil corporate control but not in a branded landscape. Indeed, Do Androids Dream of Electric Sheep, the Philip K. Dick science fiction novel on which Blade Runner is based, makes no mention of brands or advertising.
Audience reactions to director Denis Villeneuve's Blade Runner 2049, which opened on October 3rd, have been mixed, with many championing it as a worthy sequel. But far fewer are willing to defend the new film's brand inclusions. Atari, Coca-Cola and Pan-Am once again have roles in the film, even though the latter has long since disappeared. French automaker Peugeot is prominently featured as the flying auto of the future. Atari is banking its comeback on its Blade Runner foundation.
Johnnie Walker even produced a futuristic bottle to cross-promote onscreen and in stores and the spirit's corporate parent, Diageo, is emblazoned on Los Angeles' skyline early in the film. And of course, there is no escaping Sony's presence in the film, including a role for a futuristic Walkman; Sony's studio arm is a production partner.
It still cracks me up that Blade Runner 2049 presents a future so bleak that Peugeot is the dominant car manufacturer.
— Tom Grochowiak (@TomGrochowiak) October 15, 2017
It's hard to define exactly why the original Blade Runner's brand inclusions worked so smoothly and why Blade Runner 2049's do not. One reason is Blade Runner itself. For example, many have complained about the fact that Peugeot is such a prominent automaker in 2049. But in the original Blade Runner, one of the prominent auto brands was Alfa Romero. Did Blade Runner's world change or did we change?
In 1982, Blade Runner—with its giant neon branded skylines—changed everything that came after. From 1989's Back to the Future 2 to 2002's Minority Report to 2004's I, Robot to 2005's The Island to 2013's Elysium, Hollywood's view of the future is littered with brand names.
Blade Runner (1982) even changed Blade Runner 2049 (2017). Despite being a sequel, Blade Runner 2049 cannot erase the audience's memory of all that came after the 1982 original, much of with clunky and pushy product placements. Blade Runner 2049's brand inclusions seem as tired in 2017 as Blade Runner's placements seemed fresh in 1982. It's not Blade Runner 2049's fault; it's Blade Runner's fault.
Ironically, Blade Runner's inclusion of real-life brands led to the infamous "Blade Runner Curse." Many of the brand names featured in the 1982 original did not last long. Cusinart, RCA, Pan Am, Atari, Polaroid and Bell—all prominent in the original—declared bankruptcy or disintegrated.
Meanwhile, one place Blade Runner is again pushing the envelope is with its offscreen promotions. There were the online short films aimed at bringing everyone up to speed. But more importantly, there was Blade Runner 2049's embrace of VR.
Artificial Intelligence and virtual reality play a big role in Blade Runner 2049. Offscreen, the film partnered with Facebook's VR brand Oculus for virtual Blade Runner experiences. Then there is "Blade Runner 2049: Memory Lab," a short VR movie and gaming experience that has impressed critics.
Blade Runner 2049's embrace of brands offscreen is notable for how it embraces VR onscreen in the form of holograms—the Sony-enabled Las Vegas-era Elvis and Frank Sinatra—along with the depiction of an AI brand in Joe's virtual girlfriend Joi.


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In theory, the media is supposed to keep any given administration, even that of hope and change, "honest", and to report its flaws, failings, criminality and hypocrisy. In practice, this never happens, since the bulk of US, and global, media outlets are owned by a handful of corporations which in turn do everything in their power to preserve the lucrative arrangement in which the administration pretends to administer, and the media pretends to do its job.
With this kind of informational near-monopoly, corporations - and the media - are far more interested in perpetuating the crony-capitalist status quo, which in conjunction with Wall Street's bribery funding of the three branches of US government, has come to symbolize just how broken US governance has become.
For 364 days of the year, the theater that the press and the administration are on the opposite sides of the table, continues without a glitch. However, one day a year, during the annual White House Correspondents' Association dinner, the facade falls and Obama, together with his fawning press corps, have a night of laughs in an Oscar-inspired night of self-congratularoty excess. Which, just like every other night in Washington, is at the taxpayers' expense.
Among the over 2000 "guests" enjoying the jokes were Jessica Simpson, Patrick Stewart, Matthew Morrison, Anna Chlumsky, Lindsey Vonn, Katharine McPhee, Jeremy Irvine, Lupita Nyong'o, Julianna Margulies, Sofia Vergara, Brad Paisley, Kevin Hart, Cynthia Nixon, Tim Tebow, Kareem Abdul-Jabbar, J.C. Chasez, Julia Louis-Dreyfus, Olivia Munn, Jesse Tyler Ferguson, Fred Armisen, Richard Sherman and Harvey Weinstein.
The good news: the humor - written by others, of course - was good. Here are the highlights from last night's festivities.
First, Obama's punchlines reported by Reuters:
"In 2008 my slogan was, 'Yes we can.' In 2013, it was control-alt-delete," Obama joked to an audience also studded with film and television stars.
"At one point, things got so bad the 47 percent called Mitt Romney to apologize," he said, referring to 2012 presidential campaign scandal in which the Republican candidate was secretly taped saying that 47 percent of Americans have become reliant on government handouts.
The president highlighted some of the low points of his administration's last year, dwelling on the disastrous rollout of the website for his landmark health insurance reform legislation.
"Of course we rolled out HealthCare.gov. That could have gone better," he deadpanned.
Later he turned on Republican opponents in Congress who are clamoring to repeal the legislation despite higher than expected enrollment figures in the government health care exchanges: "How well does Obamacare have to work before you stop trying to repeal it?"
At the end of his speech, Obama turned the audience's attention to a video monitor, which failed to work. Kathleen Sebelius, the health secretary who announced her resignation this month after overseeing the botched rollout of Obamacare, stepped to the podium to try to fix the technical glitch.
Obama also took a swipe at Republicans for blocking his bid to raise the minimum wage. "If you want to get paid for not working you should run for Congress just like everyone else," he said.
In a self-deprecating crack at his own low popularity ratings, the president referred to his fellow Democrats not wanting to campaign with him for November congressional elections in a wistful joke involving one of his daughters: "I did notice the other day that Sasha needed a speaker for career day and she invited Bill Clinton."
"Let's face the facts, you'll miss me when I'm gone," Obama directed to the Fox News table. "It will be harder for you to convince Americans that Hillary was born in Kenya."
Some more from USA Today:
When McHale took over duties, he aimed straight at Obamacare's launch.
"It was so bad!" he said from the stage. "I don't even have an analogy, because the website is now an analogy that people use to describe other bad things. 'Boy that latest Johnny Depp movie really healthcare.gov'd at the box office.' "
A few of McHale's other best lines:
- On Chris Christie: "I promise that tonight will be amusing and over quickly. Just like Chris Christie's presidential bid."
- On Rob Ford: "Between Rob Ford, Justin Bieber and Ted Cruz, you just want to tell Canada, 'Hey, hey, relax. We already have a Florida.' "
- On Hillary running for office: Hillary Clinton has a lot going for her as a candidate. She has experience, she's a natural leader. And as our first female president, we could pay her 30% less! That's a saving this country could use. Who's with me??"
- On Chelsea Clinton's pregnancy: "In nine months we will officially have a sequel to Bad Grandpa."
Finally, the video clips:


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An environmental activist interrupted the first Senate confirmation hearing for ExxonMobil CEO Rex Tillerson Wednesday when she stood up and yelled about how Hurricane Sandy destroyed her home.
"Rex Tillerson, I reject you," said the activist before being dragged out of the Senate Committee on Foreign Relations hearing room. "My home was destroyed by Hurricane Sandy!"
President-Elect Donald Trump decision to name Tillerson as his secretary of state rankled environmentalists and Democrats who argue the U.S. should have a "Big Oil" executive making foreign policy decisions.
Some environmentalists have attacked Tillerson for being CEO of a company that supposedly tried to cover up global warming science for decades while funding conservative groups opposed to government regulations.
That's probably why the hearing heckler chose to yell about Hurricane Sandy — environmentalists say global warming strengthened the storm.
Protesters gathered on Capitol Hill to march against confirming Tillerson. Environmentalists and even Code Pink activists gathered outside Senate offices holding signs and waiting for Tillerson's hering to begin.
"Hey, hey, ho, ho, Rex Tillerson has got to go," protesters shouted before the hearing started. Some protesters were even wearing Tyrannosaurus Rex costumes.
"Trump's cabinet is a joke, climate change is not a hoax!" #RejectRex #ExxonKnew pic.twitter.com/qx44C7jlLw
— Sierra Club Live (@SierraClubLive) January 11, 2017
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Thank you to those who came out today to support the successful launch of the StopGap ramps downtown. We were grateful to have Luke Anderson present, as he is the founder of the StopGap Foundation. Also present was the Mayor of Guelph, Cam Guthrie, and election candidates Gord Miller (Green) and Lloyd Longfield (Liberal), along with Jon Beharry, the Campaign Manager for Andrew Seagram (NDP).
We would also like to give a special shout out to Jan Hamilton from Roger's for coming out too. Her coverage of the launch will air on Roger's on October 20.


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ILAB Newsletter 67 (printed)
January 2017:
The latest edition of the ILAB Newsletter has just been printed and circulated to all ILAB affiliates.
A warm welcome by the new ILAB President, Gonzalo F. Pontes; looking back at the ILAB congress in Budapest and introducing the new ILAB committee; entertaining accounts from some of our youngest booksellers in the trade who received a scholarship to join the congress "I was the youngest dealer at the 42nd ILAB Congress" by Gaelle Cambon and "Budapest" by Anke Timmermann.
ILAB recently launched a new Mentoring Programme and is asking its affiliates, whether old or young, new bookseller or established firm, to join the programme and support each other to ensure stability and the future of our trade!
While ILAB booksellers were gathering in Budapest, well known bookseller Bob Fleck died on 22 September 2016 after a short but agressive illness. He will be missed by many in the trade and we send our condolences to his family, his friends and his team at Oak Knoll.