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Author Name : Brian Flatt's
Official Website : CLICK HERE
Refund Policy : 60 Days
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Mary Ann Smith Professor and Senior Associate Dean
UNC-Chapel Hill
Molecular Therapeutics
Area of interest
The objectives of our research are to execute the synthesis of potent antitumor agents isolated from natural sources such as marine sponges. These marine metabolites are typically available in very limited quantities from their natural sources. Development of synthetic approaches to these molecules can provide increased quantities for clinical evaluation and also provide structural analogs with different biological profiles. Current target molecules in our laboratory include such antitumor agents as irciniastatin A, spongistatin 1, laulimalide, apoptolidin A and leucascandrolide A. Ultimately, perhaps less complex derivatives of these potent antitumor agents with similar or better biological activity can be prepared.
Awards and Honors
- Mary Ann Smith Distinguished Professor of Chemistry UNC-CH (2003-)
- Scientific Advisory Board, Chimerix, Inc. (2003-)
- Editorial Advisory Board, Journal of Organic Chemistry, (2004-2007)
- Charles Holmes Herty Medal, Georgia Section, American Chem. Soc. (2004)
- NIH Synthetic and Biological Chemistry A Study Section, member (2005-2009)
- North Carolina ACS Section Distinguished Speaker Award (2008)Senior Associate Dean for Natural Sciences, College of Arts and Sciences (2009-)
- Ernest Guenther Award in the Chemistry of Natural Products, American Chemical Society (2010)

subset: commoncrawl


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"I've said the same things over and over for 25 years, it doesn't matter which party is in power.
"It's the same stuff. It's the same threats. It's the same arguments, over and over. Nothing ever changes.
"We just keep spending more money. We create more dependency, we get more and more irresponsible one crisis to the next, all of them manufactured.
"Except for the real crisis that nobody ever addresses — and that is we can't afford it."
-Rush Limbaugh on his show 02/20/13-
No matter how much you like Rush Limbaugh or not. On the issue of government spending, he is right. No matter who is in charge, Republicans or Democrats, they do not do the right thing. And that is, we cannot afford to spend another penny.
Right now it is Obama proposing the sequester and saying if the republicans don't go with it, government programs that are needed will end. They are telling us that the spending cuts that are on the docket are about 80 billion, but even then they are lying to us. It is really only about 40 billion and people, 40 billion compared to the trillions in cuts that are really needed is just a drop in the bucket. Let me put it another way. If all of us were billionaires and we could use our money to help the united States out of this fiscal calamity we are in, we would all be broke…….and the nation would still be in debt to the tune of trillions of dollars! We have got to get a handle on this and stop this insanity. Obama's sequester doesn't help. It hurts. The spending cuts that are proposed are not really spending cuts. They're just cuts from the proposed spending of this year. We will still be spending more money with those cuts than we did last year, so all this bullshit about how it will hurt us if we don't do the sequester, or if we don't allow the government to spend more on another program, is just that. Bullshit.
Now I hate using words like that, but it is getting to the point where no other word suffices. And like I said in my last post, yesterday, Ronald Reagan fought the same illness when he was president, and yes, the thing we are fighting with our government now, is just that. An illness.
Remember that part of his quote from that post?
……"Do they honestly expect us to believe that if we add $1 billion to the $45 billion we're spending, one more program to the 30-odd we have — and remember, this new program doesn't replace any; it just duplicates existing programs." It is like he said, 'it isn't that they (the liberals) are ignorant, they just know so much that isn't true.' And sadly, they are dragging the American people down with their thinking. Plain and simple folks. We need to change the direction this country is being led, and get rid of all the politicians who will not do what is needed, or America will not have a future. It is as plain as the nose on your face folks. Mark my words, and as Rush says….don't doubt me. History and the things that are happening is on my side here, not Obama's or the politicians in Washington D.C..
God Bless America
God Bless our Troops
God Bless us to start thinking with our brains, and not our hearts


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Distinctiveness of Christianity
Christianity makes a big thing of being counter-cultural, but when the rubber hits the road, how much does it actually differ from the culture it claims to run counter to? I grew up understanding the sum total of Christian Morality to be a sort of middle-class respectability and politeness, and I've seen little since then to suggest that it's much deeper than that. There's variation depending on your location and flavour of church, and those different flavours will often disagree with each other, but the result always seems to be a sort of institutionalised, co-opted secular morality, reflecting the dominant culture of church members rather than an objective standard.
As if that wasn't bad enough, the church often seems to lag a long way behind general cultural trends in the morality stakes. A couple of current examples are homosexuality and the role of women. The wider population largely got over these some time ago, and is now waiting impatiently for the church to catch up. That isn't necessarily an indication that the church is doing anything wrong – it could be argued that it's holding to moral principles in the face of a hostile culture – but given that the church is in fact moving towards the centre ground of popular opinion, albeit with glacial slowness, it looks far more like the church really is following at its own pace, rather than leading.
Maybe that's not entirely fair. I've said before that the weakness of the church is that it's run by people, and maybe it's lost its way a bit over time, so what about the foundation of the church? There's plenty in the New Testament about being different and standing apart from the world, so it was radical and different back then, wasn't it? No, not really. The epistles suggest that local churches would have a strong flavour of whatever local customs there were (in the port of Corinth, for example, St Paul's main concerns appear to have related to sexually promiscuous polyglots), so the church doesn't appear to have been al that distinctive in its early days in the 1st Century.
You could argue that this is a reflection of a movement that was still young and somewhat raw and disorganised, but it never seems to have changed very much. The Letter to Diognetus – the earliest known example of Christian apologetics, dating around the late 2nd Century – appears to confirm Christianity's conformity to cultural norms, even when trying to show how different and remarkable Christians are:
Christians are indistinguishable from other men either by nationality, language or customs. They do not inhabit separate cities of their own, or speak a strange dialect, or follow some outlandish way of life… With regard to dress, food and manner of life in general, they follow the customs of whatever city they happen to be living in, whether it is Greek or foreign.
So even by the most positive interpretation of what's often regarded as the church's golden age, it appears that Christianity doesn't offer an alternative to mainstream culture so much as a slight variation. That's not so terrible, but when it's cast as distinctively counter-cultural and a source of objective morality (neither claim being particularly rare), it does cast doubt on the honesty and self-awareness of the person making the claim.
Looking at the way the church has worked in the past, the way it's shifted with culture and changed its position on various issues, I can see it as a plausible result of a lot of people trying to make the world a better place, one step at a time, through careful application of the Golden Rule. What I can't see is any way it could be the outcome of a huge community in possession of a clear, unambiguous, objective moral code.
7 responses to "Distinctiveness of Christianity"
unkleE says :
"What I can't see is any way it could be the outcome of a huge community in possession of a clear, unambiguous, objective moral code."
I wonder what you are expecting of a "moral code"? When Jesus was asked about the moral code, he gave a very simple answer – (in summary) love God, love your neighbour.
Not long before Jesus there was a famous Jewish rabbi, Hillel, who was once asked to summarise the law, and he said: "Do not unto your neighbor what you would not have him do until you; this is the whole Law; the rest is commentary." Jesus several times agreed with statements by Hillel, and it is clear that his summary is a positive version of Hillel's.
And I think Jesus would have agreed with Hillel's conclusion too: "The rest is commentary."
Many christians (IMO) misunderstand christianity as a long list of do's and don'ts, but Jesus is clear that the list is very small, but needs to be worked out in each situation.
I think christianity is indeed in possession of a clear, unambiguous, objective moral code, it's just not very detailed.
unkleE says :
Since we agreed here, there is little more to say. : )
I think God has "brought up" the human race in a similar way in which good parents bring up children. Parents start with simple do's and don'ts, gradually increase the explanations, then start to relax the rules and offer opportunities for freedom of choice and responsibility, then finally the children (by then grown up) start to make their own decisions and live their own lives.
Now I don't think we can ever live our lives apart from God, but I think the situation is analogous. Unfortunately, some christians are still living in the age of rules (the Old Testament) when they should be in the age of grace and the Spirit (the New Testament).