text:
Safety and Efficacy of Self-Expanding TAVR in Patients With Aortoventricular Angulation
Author + information
- Received March 17, 2016
- Revision received June 13, 2016
- Accepted June 15, 2016
- Published online August 1, 2016.
Author Information
- Jeffrey J. Popma, MDa,∗ (jpopma{at}bidmc.harvard.edu),
- Michael J. Reardon, MDb,
- Steven J. Yakubov, MDc,
- James B. Hermiller Jr., MDd,
- J. Kevin Harrison, MDe,
- Thomas G. Gleason, MDf,
- John V. Conte, MDg,
- G. Michael Deeb, MDh,
- Stanley Chetcuti, MDh,
- Jae K. Oh, MDi,
- Michael J. Boulware, PhDj,
- Jian Huang, MDj,
- David H. Adams, MDk,
- CoreValve US Clinical Investigators
- aBeth Israel Deaconess Medical Center, Boston, Massachusetts
- bHouston-Methodist-Debakey Heart and Vascular Center, Houston, Texas
- cRiverside Methodist Hospital, Columbus, Ohio
- dSt. Vincent's Heart Center of Indiana, Indianapolis, Indiana
- eDuke University Medical Center, Durham, North Carolina
- fUniversity of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
- gJohns Hopkins Medical Center, Baltimore, Maryland
- hUniversity of Michigan Medical Center, Ann Arbor, Michigan
- iMayo Clinic Foundation, Rochester, Minnesota
- jMedtronic, Minneapolis, Minnesota
- kMount Sinai Health System, New York, New York
- ↵∗Reprint requests and correspondence:
Dr. Jeffrey J. Popma, Beth Israel Deaconess Medical Center, 185 Pilgrim Road, Boston, Massachusetts 02215.
Objectives The aim of this study was to determine the relationship between aortoventricular (AoV) angulation on clinical outcomes after self-expanding transcatheter aortic valve replacement (TAVR) in patients with severe aortic stenosis who were deemed suboptimal for surgery.
Background Multidetector computed tomographic (MDCT) imaging of the aortovalvular complex has become a prerequisite for case planning with self-expanding TAVR. The effect of aortic angulation, an index of an unfolded or "horizontal" aorta, on procedural outcome after self-expanding TAVR is not known.
Methods The clinical course of 3,578 patients who received implants in the CoreValve US Clinical Trials and who had prospective MDCT estimation of the AoV angle before the procedure was reviewed. Clinical site echocardiogram assessments were used to determine the degree of residual aortic regurgitation 24 to 48 h after the procedure and at 30 days. On the basis of the measurement of the AoV angle on MDCT, patients were categorized into septiles, ranging from the lowest septile of an AoV angle <37.0° to the highest AoV angle septile of >55.0°.
Results Patients were elderly (age 83.3 ± 7.8 years) and were at high risk for surgical valve replacement (Society of Thoracic Surgeons Predicted Risk of Mortality 8.8 ± 4.7). Greater degrees of AoV angulation were correlated with older age (p < 0.0001). Although procedure time was 6.9 min longer in the highest septile (59.4 ± 35.9 min vs. 52.5 ± 35.3 min in the lowest septile; p = 0.004), there were no linear trends (p > 0.05) in the frequencies of device success, procedural success, frequencies of moderate or greater aortic regurgitation at 30 days, number of valves implanted, or need for balloon post-dilation or new pacemakers among the AoV angle septiles.
Conclusions The degree of AoV angulation does not affect early clinical outcomes self-expanding transcatheter aortic valve replacement. (Safety and Efficacy Study of the Medtronic CoreValve® System in the Treatment of Symptomatic Severe Aortic Stenosis in High Risk and Very High Risk Subjects Who Need Aortic Valve Replacement [Medtronic CoreValve® U.S. Pivotal Trial]; NCT01240902)
Transcatheter aortic valve replacement (TAVR) is an alternative to surgery in higher risk patients with severe, symptomatic aortic stenosis (1,2). Self-expanding TAVR resulted in a reduction in mortality in extreme-risk patients compared with medical therapy (3,4) and in high-risk patients compared with surgery (5,6). The improved outcome with self-expanding TAVR relates to an improved recovery with TAVR (7), reduction in stroke (6), and fewer bleeding complications and episodes of atrial fibrillation (5) with self-expanding TAVR than surgery. Valve hemodynamics, including larger aortic valve effective orifice areas (5), lower aortic valve gradients (5), and less patient–prosthesis mismatch (8) are better with TAVR than surgery.
A critical component of pre-procedural planning in patients undergoing self-expanding TAVR includes a detailed analysis of multidetector computer tomographic (MDCT) imaging of the aortovalvular complex. Prior studies have shown the value of MDCT for case planning in determining annular sizing for bioprosthesis size selection (9–12), estimating dimensions of the aortic root (13), quantification of the location and distribution of calcification (14,15), and location of the coronary heights (13). MDCT can also estimate the angulation of the ascending aorta relative to the left ventricular cavity and outflow tract, providing an estimation of the degree of "unfolding" or horizontal contour of the aorta. Although proper positioning of the annular portion of the self-expanding bioprosthesis during implantation may be more challenging in the setting of a marked aortic angulation (16–18), no prior study has assessed the prognostic value of the aortoventricular (AoV) angle in a large series of patients undergoing self-expanding TAVR using contemporary best practice implantation methods.
The purpose of this analysis was to study the effect of the AoV angulation on device success, procedural outcomes, and the presence of moderate or severe aortic regurgitation (AR) after self-expanding TAVR in patients with severe aortic stenosis deemed suboptimal for surgery.
A total of 3,578 patients received a self-expanding transcatheter aortic valve in the CoreValve US Pivotal Trial or Continued Access Study at 45 clinical sites in the United States. The details of these studies have been reported elsewhere (4–6,13), but in brief, patients with New York Heart Association (NYHA) functional class II or greater symptoms were eligible for inclusion. Extreme-risk patients had a surgical risk of death or majority morbidity ≥50% at 30 days, and high-risk patients had a 15% or greater risk of surgical mortality at 30 days as assessed by a multidisciplinary heart team using the Society for Thoracic Surgeons Predicted Risk of Mortality (STS PROM) and other nontraditional risk factors. Severe aortic stenosis was defined as an aortic valve area ≤0.8 cm2 or aortic valve index ≤0.5 cm2/m2 and either a mean aortic valve gradient >40 mm Hg or a peak aortic valve velocity >4.0 m/s, at rest or with dobutamine. Anatomic exclusion criteria included an aortic annular diameter <18 mm or >29 mm. Patients were treated with a 23-mm, 26-mm, 29-mm, or 31-mm CoreValve device (Medtronic, Minneapolis, Minnesota).
Multidetector computed tomography angiography
All patients considered for inclusion in these studies underwent MDCT angiography (64-slice minimum) with retrospective electrocardiographic gating. AoV angulation was determined by angle of the aortic annulus and the horizontal plane in the end-systolic coronal view (Figure 1). Clinical sites measured the AoV angle, and a central imaging laboratory confirmed the values for protocol adherence using standardized software (3 Mensio, Pie Medical Imaging, Maastricht, the Netherlands). An AoV angle 70° or less was required for patients treated with a transfemoral or left subclavian approach; an AoV angle 30° or less was required for patients treated with a right subclavian approach (3,5). There were no AoV angle exclusion criteria for patients undergoing a direct aortic approach for self-expanding TAVR (19). Self-expanding bioprosthesis sizing was based on perimeter-based annular diameters (18- to 20-mm, 23-mm bioprosthesis; 20- to 23-mm, 26-mm bioprosthesis; 23- to 27-mm, 29-mm bioprosthesis; 26- to 29-mm, 31-mm bioprosthesis).
Procedural details
The self-expanding TAVR placement was targeted to an inflow implant depth between 4 to 6 mm inferior to the noncoronary basal annulus. After valve deployment, valve performance was evaluated using transthoracic or transesophageal echocardiography, aortography, and invasive measurements of transaortic valve gradients and left ventricular end-diastolic pressures. Post-dilation was recommended in the event moderate or severe AR was identified using these parameters due to incomplete frame expansion.
Echocardiographic analysis
Clinical site echocardiographic evaluations were obtained within 24 to 48 h, at discharge and at 30 days after the procedure. Recommendations were made to the clinical sites for adherence to the Valve Academic Research Consortium (VARC) criteria (20,21). Residual AR was classified as none, mild, moderate, or severe. No designation for trace AR was included in the analysis consistent with the VARC criteria (20,21).
Clinical outcomes
Clinical events were adjudicated by an independent clinical events committee using VARC1 methodology, and included all-cause mortality, all stroke, major stroke, minor stroke and major adverse cardiovascular or cerebral events (MACCE), defined as all-cause mortality, myocardial infarction, all stroke, or reintervention to alter, adjust, or replace a previously implanted valve. Device success and procedural success were defined using VARC1 criteria (20,21). The need for a permanent pacemaker and rehospitalization for congestive heart failure was also analyzed.
Statistical analysis
All patients who were implanted with TAVR are included in the analysis. The cohort was divided into septiles based on AoV angle. To maximize the potential for identifying an associate between clinical outcomes and AoV angle, a second cohort was also stratified into 7 subgroups of unequal size but in clinically relevant 10° increments. Categorical variables were compared with the use of the Cochran-Armitage Trend test. Continuous variables were presented as mean ± SD, and a general linear regression model was used with AoV angle (ordinal scale) as the only independent variable to test linear trend. Kaplan-Meier event estimates were used to construct the survival curves based on all available follow-up data for the time-to-event analysis. The log-rank test for trend was performed to compare the time to events. All testing used a 2-sided alpha level of 0.05. All statistical analyses were performed with the use of SAS software, version 9.4 (SAS Institute, Cary, North Carolina).
Baseline characteristics
Clinical demographics of patients are found in Table 1. Patients were elderly (age 83.3 ± 7.8 years) and were high risk for surgical valve replacement (STS PROM 8.8 ± 4.7). Greater degrees of AoV angulation were correlated with older age (p < 0.0001) but inversely correlated with peripheral vascular disease (p = 0.001), chronic lung disease (p = 0.019), prior coronary bypass surgery (p = 0.023), prior percutaneous coronary intervention (p < 0.0001), aortic calcification (p = 0.010), and a hostile mediastinum (p = 0.002).
Procedural findings
Procedural findings are found in Table 2. Overall procedure time was 6.9 min longer in the highest septile (59.4 ± 35.9 min vs. 52.5 ± 35.3 min in the lowest septile; p = 0.004). There was a greater utilization of an iliofemoral approach among patients with a larger AoV angle (p = 0.006) and less use of a subclavian access (p = 0.002). Use of a 31-mm bioprosthesis was also correlated with higher AoV angles (35.2% in the highest septile compared with 25.8% in the lowest septile; p = 0.027). There were correlations (p > 0.05) among the groups for more than 1 valve implanted, bioprosthesis retrieval or repositioning, or valve-in-valve procedure with higher degrees of AoV angle.
Clinical and echocardiographic outcomes
Device and procedural success rates are found in Table 3. The overall device success rate was 86.8% and the overall procedural success rate was 80.4%. There were no correlations for reduced procedural or device success by AoV angle (Figure 2A).
Transthoracic echocardiographic findings are found in Table 4. There was no correlation of moderate or severe total AR in patients based on the AoV angle (Figure 2B). Clinical outcomes at 30 days are found in Table 5. Clinical follow-up was available in 94.4% of patients. The 30-day all-cause mortality rate was 5.4% and all stroke rate was 4.8%. We did not find a relationship between AoV angle and all-cause mortality, major stroke, MACCE, rehospitalization, or use of a permanent pacemaker.
Our analysis did not identify a relationship between AoV angulation and clinical outcome in 3,578 patients undergoing self-expanding TAVR for severe aortic stenosis deemed suboptimal for surgery. These findings support the use of self-expanding TAVR in patients using best practice principles, including pre-procedural MDCT screening, case planning, and implantation practices targeted to reduce the degree of residual AR.
Case planning using MDCT has become an integral part of contemporary TAVR practice. Use of MDCT has had a profound impact on the reduction of residual AR due to appropriate bioprosthetic sizing (9,12), and has allowed identification of unfavorable calcium morphology within the aortic annulus and left ventricular outflow tract that may enhance the selection of the transcatheter heart valve (14,15). Pre-procedural sizing of the aortic root and identification of the origin of the coronary arteries has reduced the occurrence of coronary occlusion during the procedure (22,23).
An estimation of the aortic angulation at the juncture of the aorta and the annulus perpendicular to the centerline of the left ventricular outflow tract can also be identified using MDCT, and the AoV angle has allowed identification of patients with severe aortic angulation (Figure 1), so called "unfolded" or "horizontal" aortas. Prior case reports have identified the technical challenges of self-expanding TAVR with extreme AV angulation (16,18), and one early series of 50 patients who underwent self-expanding TAVR found that the chance of significant AR increased with a greater angulation (odds ratio: 1.24; p = 0.001) and due to the implantation depth of the bioprosthesis (17).
Our clinical studies have recommended that a direct aortic approach be used with severe aortic angulation, and limited iliofemoral and left subclavian access to those patients with an AV angle 70° or less (3,5). We did not find a relationship between the AoV angle and device success, procedural success, or clinical outcomes in the CoreValve US Clinical Trials using these parameters. We attribute this nonassociation to best practice techniques in the setting of greater degrees of aortic angulation. Best practice techniques include use of coplanar aortography that allows simultaneous visualization of the noncoronary, right, and left coronary sinuses, alignment of the delivery catheter along the greater curvature of the aorta using stiffer guidelines (e.g., SuperStiff Amplatz or Lunderquist 0.035-inch guidewires), stabilization of the delivery catheter using gentle forward force on the delivery catheter guidewire positioned in the left ventricular apex, alignment of the delivery catheter marker to allow visualization of the inflow of the prosthesis in a coaxial alignment, slow deployment and controlled annular contact to stabilized the valve frame, avoidance of deeper implantation by forward tension on the delivery guidewire and retraction on the catheter, and careful assessment of the hemodynamic and echocardiographic results after deployment. We believe that careful attention to these practices mitigated the effect of AoV angle on procedural outcomes in our study.
Newer generations of the self-expanding bioprosthesis may improve the ability to treat patients with even more complex anatomy (24). The fourth-generation Evolut R self-expanding bioprosthesis includes a 14-F equivalent EnVeo R Deliver Catheter System (Medtronic), a modified nitinol design at the annulus that optimizes radial expansive force, a longer porcine pericardial sealing skirt, and a nitinol delivery catheter capsule that allows resheathing and recapturing during deployment (24). Relevant to this discussion, the nitinol capsule can result in "self-centering" of the device during deployment, allowing more symmetric annular contact during early deployment (24). The 23-mm, 26-mm, and 29-mm Evolut R valves are currently approved for clinical use in the United States and Europe.
Study limitations
We did not test the effect the AoV angulation beyond the guidelines recommended for commercial practice. Accordingly, the results of self-expanding TAVR have not been systematically evaluated in patients with extremely large annular diameters (i.e., perimeter >91.1 mm or perimeter-derived diameter >29 mm) or using the iliofemoral approach with highly angulated (>70°) aortas. In the latter circumstance, conversion to a direct aortic access approach is recommended with self-expanding TAVR. The low rates of mortality and stroke were comparable to the rate of loss to follow-up for 30-day events. More sophisticated methods to assess thoracic and abdominal aortic angulation may be a more predictive measure of procedural complications that the empiric angulation parameters that have been historically used.
We conclude that the AoV angle was not an important determinate of clinical outcomes after self-expanding TAVR when it was used within commercial practice anatomic guidelines and utilizing best practice implantation techniques. Newer self-expanding designs that facilitate self-centering may expand the use of this bioprosthesis into highly angulated aortas, but further study is needed.
COMPETENCY IN MEDICAL KNOWLEDGE: MDCT imaging has been useful for case planning in patients undergoing TAVR. Self-expanding TAVR can be safely performed in patients with moderate (up to 70°) of aortic angulation based on MDCT imaging without a compromise in procedural safety or efficacy.
TRANSLATIONAL OUTLOOK: Newer generations of self-expanding transcatheter heart valves have been developed, and these iterations may improve the ability to treat patients with more severe aortic angulations. Performance of self-expanding TAVR in patients with a horizontal aorta (>70°) will require further study.
The authors thank Colleen Gilbert, PharmD, an employee of Medtronic, for technical editorial support.
Funded by Medtronic. Dr. Popma has received grants from Medtronic, Boston Scientific, and Direct Flow Medical; consulting fees from Boston Scientific and Direct Flow Medical; and equity from Direct Flow Medical. Dr. Reardon has received fees from Medtronic for consulting and providing educational services. Dr. Yakubov has received grant support from Medtronic, Boston Scientific, and Direct Flow Medical; and served on advisory boards for Medtronic and Boston Scientific. Dr. Hermiller has received fees for consulting and educational services from Medtronic. Dr. Harrison has received institutional grants from Medtronic, Boston Scientific, Direct Flow Medical, St. Jude Medical, and Edwards Lifesciences; and serves on a Medical Advisory Board for Direct Flow Medical and on the Data Safety Monitoring Board for CardiAQ. Dr. Gleason receives institutional grant support from Medtronic but receives no personal income. Dr. Conte has received research funding from Medtronic and Boston Scientific; and serves on a surgical advisory board for Medtronic and Sorin. Dr. Deeb serves on an advisory board and as a proctor for Medtronic; as a consultant and research investigator for Edwards Lifesciences; as a consultant and proctor for Terumo; and as a research investigator for Gore Medical; he receives no personal remunerations. Dr. Chetcuti has received grant support from Edwards Lifesciences, Boston Scientific, and Medtronic; and proctoring fees from Medtronic. Dr. Oh has received core laboratory and consulting funding from Medtronic. Dr. Boulware is an employee and shareholder of Medtronic. Dr. Huang is an employee of Medtronic. Dr. Adams has received grant support from Medtronic; and has royalty agreements through Mount Sinai School of Medicine with Medtronic and Edwards Lifesciences.
- Abbreviations and Acronyms
- AoV
- aortoventricular
- aortic regurgitation
- major adverse cardiovascular or cerebral events
- multidetector computed tomographic/tomography
- New York Heart Association
- transcatheter aortic valve replacement
- Society of Thoracic Surgeons Predicted Risk of Mortality
- Valve Academic Research Consortium
- Received March 17, 2016.
- Revision received June 13, 2016.
- Accepted June 15, 2016.
- American College of Cardiology Foundation
- ↵
- Nishimura R.A.,
- Otto C.M.,
- Bonow R.O.,
- et al.,
- ACC/AHA Task Force Members
- Vahanian A.,
- Alfieri O.,
- Andreotti F.,
- et al.
- ↵
- Popma J.J.,
- Adams D.H.,
- Reardon M.J.,
- et al.,
- CoreValve United States Clinical Investigators
- ↵
- Yakubov S.J.,
- Adams D.H.,
- Watson D.R.,
- et al.,
- CoreValve United States Clinical Investigators
- ↵
- ↵
- Reardon M.J.,
- Adams D.H.,
- Kleiman N.S.,
- et al.
- ↵
- Arnold S.V.,
- Reynolds M.R.,
- Wang K.,
- et al.,
- CoreValve US Pivotal Trial Investigators
- ↵
- ↵
- Hansson N.C.,
- Thuesen L.,
- Hjortdal V.E.,
- et al.
- Willson A.B.,
- Webb J.G.,
- Labounty T.M.,
- et al.
- Jilaihawi H.,
- Kashif M.,
- Fontana G.,
- et al.
- ↵
- Popma J.,
- Almonacid A.,
- Litmanovich D.,
- Gellert G.
- ↵
- John D.,
- Buellesfeld L.,
- Yuecel S.,
- et al.
- Khalique O.K.,
- Hahn R.T.,
- Gada H.,
- et al.
- ↵
- ↵
- Sherif M.A.,
- Abdel-Wahab M.,
- Stocker B.,
- et al.
- ↵
- Reardon M.J.,
- Adams D.H.,
- Coselli J.S.,
- et al.,
- CoreValve US Clinical Investigators
- ↵
- Leon M.B.,
- Piazza N.,
- Nikolsky E.,
- et al.
- ↵
- ↵
- Manoharan G.,
- Walton A.S.,
- Brecker S.J.,
- et al.


text:
Waterproof Antennas: Low-Cost Plastic vs. Stainless Steel & Fiberglass
There are many applications in which waterproof plastic antennas serve very well as a low cost option: Home and small business WiFi and LTE, Bluetooth, Internet of Things (IOT), and many more applications.
Antennas made from fiberglass and stainless steel are typically double the price of plastic waterproof antennas of the same gain and VSWR, but they are a lot more durable. The higher-end fiberglass and steel waterproof / weatherproof antennas, being resistant to rust and corrosion, along with their strength, durability and flexibility, make them ideal for long length rod antennas mounted vertically. They are commonly used in marine applications.

subset: commoncrawl


text:
Delete a contact on an Apple iPhone
Edited by Market Maker, Cave Man, Timbuktu, Charmed and 5 others
A lot of times we get calls from people that we barely know and we save their number just in case we might need it.
Other times we save contacts that we think we might use later on, like the number of a florist or other service. Then we don't use them or you may use them only once. You may even have contact numbers of people you have lost touch with and know you won't contact them again. Every now and then you may want to clean up your contacts list.
If you are an iPhone owner and you are having trouble deleting a contact on your iPhone, then the following steps will guide you. And for extra safety, we will be showing you the way to backup and restore your iPhone contacts, as well. Here are the steps required to delete a contact from your contacts list on your Apple iPhone.
Backup Your iPhone
- 1When you connect your device to the computer, iTunes will start. If it doesn't, then start it manually by clicking on the program's icon.Connect your iPhone with the USB cable to your computer, or connect wirelessly.
- 2
- 3All you will have to do is choose whether you want to save your backup on "iCloud" or on "This Computer". After you choose between them, you will click "Back Up Now".In the Summary tab you will find the backups.
- 4After it is done with the backup process, you can unplug it from the computer, and use it.Leave your device connected to the computer while you back it up.
Delete a Contact on your iPhone
- 1
- 2You will find the Contacts icon there, click on it to access your contacts list.After you click on the Phone icon, you will find different tabs inside on the bottom.
- 3You can also go through your contacts list for contacts you don't need, and feel like deleting.Search your contacts list to locate the contact you would like to delete.
- 4After you click on the contact that you wish to delete, their contact information - that you saved - will now appear in details.Tap on the contact's name.
- 5Click on the Edit button, it will give you access to editing the name, number, or information.On your iPhone's contact card, you will find the Edit button at the top right corner of the screen.
- 6Scroll down the screen, skipping all the fields in the contact's card, till you reach the Delete Contact button.Scroll all the way to the bottom of the page.
- 7This is how you will get rid of a contact's card on your contacts list.Tap the red Delete Contact button.
- 8When you click on delete, a confirmation dialogue will appear, giving you the choice of confirming deletion or canceling the process to keep the number. So to delete the contact, you will choose the red Delete Contact button again.Tap on Delete Contact.
- 9It will delete the contact's card in a second.Your contact will now be deleted from your iPhone.
Restore Deleted Contacts on Your iPhone
If you find yourself regretting a contact's deletion or that you deleted a contact by mistake from your device, then it would be a good thing to restore the contact card or contacts.
- 1You will find the contact that you deleted in the Address Book in your OSX, or in iCloud on the web, and to get the contact back, you will:This is what you can do if you haven't synced your iPhone - after deleting the contact - with iCloud or the Contacts app in OSX.
- Launch the Contacts App or iCloud on the web, and search for the contact you have deleted.
- Open the contact's card, and click on the sharing button arrow, and select Email Card, which will open the mail app window with the attachment of the contact's vCard.
- Email the contact's vCard to yourself.
- Open your mail app on the iPhone itself, then select the vCard attachment, and click on Create New Contact.
- 2Though this way is simple and easy, you have to know that this may not work because your iPhone could have automatically synced with iCloud after the contact's deletion. This means it could have updated your iCloud contact's list by removing the contacts you removed from your device, and if it worked, it will restore all the deleted contacts. You will do this Re-Syncing by:Another way to try is by Re-Syncing your contacts from iCloud.
- Open your Settings menu on your iPhone, and select iCloud. You should be signed in to your iCloud account to show you the apps you access from contacts, calendars, and so on.
- Tap the Contacts button to switch it off, and it will show you a dialogue that asks you about previously synced iCloud contacts, so you will choose Keep on My iPhone.
- Switch the Contacts back on, and a dialogue will show up, asking you whether to Merge or Cancel, so you will click on Merge, and it will merge the contacts on your iCloud account with the ones on your iPhone. This way you may restore the contacts you have deleted.
- 3If you back up your device on a regular basis, then you will be able to restore the deleted contacts easily. If you have backed up your iPhone after deleting the contacts, then you can just restore from an older backup version that was before the deletion. All you will need to do to is:If all else fails, then using an iTunes Backup to Restore is the way.
- Connect your iPhone to your computer, and open iTunes.
- Select your iPhone, and open the Summary tab.
- Click on Restore from Backup, and choose the latest backup or the one prior to deletion.
- Your iPhone will now restore, it may take a while, so keep it connected to the computer, and when restoring is done, your iPhone will reboot and all of your contacts will be restored.
- It is better that you back up your iPhone on the computer or iCloud first, in case you accidentally delete a contact, or need the number you deleted again, because the backup will help you restore the contact from your computer or your iCloud account.
- You can use an app that deletes multiple contacts at the same time; just search for an app and you will find free apps at Apple's app store that could do such tasks.
- You can delete contacts using your iCloud Address Book, by pressing Ctrl and clicking on the names you want to delete, if you want to delete more than one contact. Then click on the Edit menu and press "Delete cards" (if you are using Mac), or click on "Actions", then "Menu", and then press "Delete Contact" (if you are using Windows), or just click on the delete button on your keyboard.
If you have problems with any of the steps in this article, please ask a question for more help, or post in the comments section below.
Article Info
Categories : IPhone
Recent edits by: Robbi, Rebecca M., Rowan


text:
UFP-Edge pattern stock sets the bar high with precisely profiled pattern stock that uses high-quality lumber free of wane.
When it comes to premium profile products, give your customers an edge—with UFP-Edge™.
Our pattern stock begins with the highest-grade lumber available, free of wane and with only small, tight knots that highlight the warm characteristics of natural wood. Then we shape and mould it using equipment and processes that protect the integrity of the wood and the finished piece. Our pattern stock includes:
In addition to premium profile products we carry gorgeous home accent and DIY project products that will be sure to help you achieve your dream home look. Our UFP-Edge Rustic Collection is new lumber that has been distressed to give a rough sawn textured appearance. Each board is primed and painted giving it the authentic look and texture of vintage rustic wood. The Rustic Collection is available in both shiplap siding and trim boards. Both options are ideal for creating accent walls, focal points and creative wood craft projects.
UFP-Edge Charred Wood which is made from well-crafted with lumber that has been carefully burnt to highlight the woods natural beauty. The contrast of its dark-charred top-surface and distinct spruce woodgrain distinguishes it from any other. Each board is sealed satin clear coat to preserve and protect its outer surface. Charred wood is available in both shiplap siding, trim and boards.
Visit Ufpi.com/Careers to view open jobs.
The companies of Universal Forest Products serve retailers, builders and other businesses, and don't sell to the general public or allow for product pick-up at our operations.
Please contact us via the phone number below, or simply fill out the form below and someone will be in touch with you soon.
Contact: (817) 222-2233
444 Sansom Blvd.
Saginaw, TX 76179
Phone: (817)232-2233


text:
Best Black Kitchen Faucets 2020 : Reviews and Buying Guide
With the traditional designs giving way to modern and contemporary kitchens, black is the colour of the day. Not only do they add the modern touch to the kitchen very easily but they go with almost every color code that graces your kitchen. Black is also easy to maintain. People are no more skeptical about using black more and more consumers are going for black kitchen faucets these days. Hence most renowned companies have their share of black matte finish kitchen faucets and here's a list of the best ones of 2020 that are doing the rounds.
Our Best Black Kitchen Faucets 2020
|Best Bathroom Faucets
|Faucet Style
|Editor Rating
|Buy Now
|Pfister GT529-IHB Kai 1-Handle Pull-Down Kitchen Faucet
|Check on Amazon
|Kraus KPF-1610MB Bolden Kitchen Faucet
|Check on Amazon
|Delta Matte Black 9113-BL-DST
|Check on Amazon
|Moen 7594BL Arbor One-Handle High-Arc
|Check on Amazon
|KOHLER K-596-BL Simplice High-Arch
|Check on Amazon
Best Black Kitchen Faucets 2020 Reviews
Founded in 2010, Pfister is a well-known name when it comes to the manufacturing of kitchen and bathroom faucets. With a vast experience in this field, the Pfister has come up with the first of it's kind innovative kitchen faucet, wherein the handle has been incorporated into the whole faucet essence to create a single fluid form. The Pfister has taken the design of this black kitchen faucet to a different level altogether and converted it into a work of art, such that it will attract your attention in almost no time and give your kitchen an artistic touch.
The Pfister GT529-IHB Kai features a high arc goose neck spout and a unique diamond pillowed patterned pull down spray. The pattern or texture adds elegance to the design and enhances the grip of the pull down spray. The goose neck spout enhances the clearance area under the spout and the reach. The pull down spray can be adjusted to stream, spray and pause mode single handedly with the help of toggle buttons at the mouth of the spout. The stream mode acts as a vessel filler while the spray mode aids in rinsing and you can just pause and prevent the wastage of water when not in use. The pull down spray automatically retracts to its original position and you do not need to do it manually. You can swivel the spout to 360 degrees thereby maximizing the working space and adding greater access to various areas of the sink. The faucet has a spout height of 11-9/16", a reach of 9-9/16" and a flow rate of 1.8GPM.
Also Check Best white kitchen Faucets
The black kitchen faucet has a solid industrial grade metal construction and has guaranteed leak proof ceramic disc valves that adjust the water pressure as well as the temperature.
The faucet is suitable for single hole installation and can also be adopted for 3 hole installation with the help of a deck plate that has to be purchased separately. The faucet installation kit includes 36" integrated nylon supply lines with 3/8" female fittings.
The Pfister kai complies with NSF/ANSI 372 and abides by the lead content requirements for "lead-free" plumbing as defined by the laws of California, Vermont, Maryland and Louisiana State and the US safe drinking water Act. It also meets the requirements of ADA for accessibility to all disabled persons.
The faucet comes with a Pfister Pforever Lifetime warranty on the finish and the function of the black kitchen faucet. If the faucet is being used commercially then the warranty period is limited to 10 years.
- Unique single solid fluid design
- High arc spout neck with 3 functions pull down spout
- Easy installation
- Ceramic disc valves and metal construction
- ADA, Cal Green, NSF compliant
- Pfister Pforever lifetime warranty
- Expensive
The only pull out kitchen faucet to make it to our list of best black kitchen faucet is also from the house of Pfister. This pull out faucet is from Pfister's Shelton collection which is famous for its bold solid lines with clean geometric form that adds sophistication to the design. The faucet allows for unobstructed viewing and prevents splashing of water due to its compact design. It comes with a similar black matte finish top filling soap dispenser that compliments the faucet to the "T". The faucet calls for easy single, double,triple or four hole installation with the option of an additional deckplate.
A single lever handle controls all the functions of adjusting the water temperature as well as the pressure of water flow.
The spout has a 360 degree swivel for maximum maneuverability. The pull out mid-arc spout head can be toggled between spray and stream options easily. It calls for single handed operation and retracts to its original position once the job is done. It has a spout height of 8.4", a spout reach of 8.7" and a flow rate of 1.8GPM. The EZ clean spray head lets you clean the head of any mineral or calcium deposition with the simple rubbing of your fingers.
The Pfister FWKP701B Shelton pull out faucet has a brass construction and the Pforever Seal leak proof ceramic disc valves which makes it durable and suitable for prolonged use. The finish as well as the function is backed by the Pfister Pforever Lifetime Warranty that will take care of almost everything.
The Pfister FWKP701B Shelton is very easy to install. It comes with a detailed instruction manual and easy to connect hoses. The installation is a simple "do it yourself" thing and you do not need professional help.
The Pfister FWKP701B Shelton meets the low lead standards as set by NSF and is ADA and CEC compliant.
- Compact design with matching soap dispenser
- Pull out spout head with spray and stream options
- Easy installation
- Ceramic disc valves and brass construction
- ADA, CEC, NSF compliant
- Pfister Pforever lifetime warranty
- Expensive
Founded in 2007, Kraus has taken an important part in revolutionizing affordable kitchen and bathroom designs. The Kraus KPF-1610MB is a member of the Kraus Bolden series. The Bolden series boasts off ansforming your kitchen to a completely new level of culinary work space experience wherein it beautifully merges the look of a professional black kitchen faucet with the convenience of a pull down sprayhead. The black matte finish is corrosion and rust resistant.
The compact faucet with an industrial style open spring spout has a height of 18″ which comfortably fits in under any kitchen cabinet. This is accompanied by a 22″ long pull out nylon hose that will enable you to reach any area in the sink with equal ease. The pull out hose is smooth and retractable. The hose end in a dual mode spout head with a rocker switch. The rocker switch aids in switching over from the spray mode to the stream mode. The mouth of the spout head has soft silicon nozzles that can be easily cleaned with the rubbing of fingers and prevents hard deposition of minerals and limestone which results in blocking of the water flow. The spout can be moved 180 degrees for easy access.
The handle comprises of a single lever that operates upto 90 degrees in the forward direction so as to bring about easy installation even in tighter compact places with no requirement for back splash clearance.
The Kraus Bolden KPF-1610MB has a solid heavy duty brass built, best in industry ceramic cartridges and backed by the limited lifetime warranty you can actually vouch for the quality and durability of a Kraus product.
The Kraus Bolden KPF-1610MB meets the standards set by NSF and is ADA,Cal Green and CEC compliant to name a few.
Overall, a very handy and long lasting product that will add a professional approach to your kitchen, the Kraus Bolden KPF-1610 MB is definitely worth invcesting in.
- Compact professional design
- 18″ arc fits under any kitchen cabinet
- Heavy duty brass construction
- 22″ pull out hose
- ADA, CEC, NSF compliant
- Limited lifetime warranty
- High arc can cause splashes
- Expensive
With quite a few awards in its kitty for it's simple yet motivating innovations, Delta is a popular brand and this Delta Essa Single Handle Pull Down Kitchen Faucet stands testimony to the reputation that Delta stands for. The Delta Essa 9113-BL-DST has a sophisticated yet minimalistic approach towards it's design. This soft take on the european design is the focal point of the look that adds elegance to your kitchen.
The Delta Essa 9113-BL-DST is a high arc pull down faucet that swivels 360 degrees. The pull down faucet is equipped with a 20″ flexible hose and a MagnaTite Docking system that enables the spray wand to snap back to the docking station smoothly. The magnet holds the spout head in position and prevents it from drooping.The spout head has soft rubber spray nozzles that will allow you to simply wipe off the mineral build up without much effort. The Delta pull down spray wands come free with a gentle tug that gives you maximum flexibility. The two function spray wand can be easily toggled between the spray and the stream mode with the help of an ergonomically placed switch.
The Delta Essa 9113-BL-DST has a single lever handle for operation. This handle controls both the temperature as well as the pressure of water flow. The Delta Diamond Seal technology is one of the best in the industry and last twice as long as the standard cartridge and reduces the leak points. This coupled with the brass construction of the faucets brings about durability to the product.
The Delta Essa 9113-BL-DST can be easily installed in a single or a three hole installation unit and the kit comes with InnoFlex PEX one piece supply lines that not only add to the ease of installation but eliminates the risk of leaks as well. It has a flow rate of 1.8GPM @60psi.
The Delta Essa 9113-BL-DST is ADA compliant and is backed with Delta Faucet's Lifetime Limited warranty.
- Sleek Euro Design
- MagnaTite Docking System
- Delta Diamond Seal Technology
- ADA compliant
- Limited lifetime warranty
- Low pressure
Any company's motto will tell you a lot about the company. Moen has a simple motto of designing and delivering beautiful products that will last a lifetime. The Moen 7594BL Arbor is a proof of the fact that Moen succeeds in delivering what it aims for. The Moen 7594BL Arbor has an elegant design tailored to perfection with a gentle curve in the handle that adds a bit of flare and a distinctive Moen touch. The design suits almost all decorating styles. The handle has a nice smooth grip and aids single handed operation.
The high arc design facilitates the cleaning and filling of large utensils and the pull down spout head, with a ahose length of 68″, provides the necessary maneuverability to reach different areas of the sink effortlessly and with ease. Once released the hose return to its original position smoothly and docks the spout head securely to the docking station. It has a maximum flow rate of 1.5GPM.
The dual function heavy duty spray can be switched between spray and stream mode. The Power Clean option intensifies the water flow for more efficient rinsing with just the push of a button while reducing backsplash. It is said to be 50% more powerful than standard Moen faucets without Power Clean.
The Moen 7594BL Arbor can be easily installed with the help of the Duralock Quick-Connect Installation system. This calls for hassle free and leak proof installation without the need of professional help.
The Moen 7594BL Arbor complies by ADA and meets the current legislation, including ab1953 (california) and s152 (vermont).
The Moen faucet is backed by a limited lifetime warranty.
- Elegantly curved handle
- 68″ pull down hose
- Power boost technology
- ADA compliant
- Limited lifetime warranty
- Low Flow rate
- Metal construction not as durable as brass
With more than 100 years of experience backing it along with 50 manufacturing locations over a spread of 6 continents, Kohler has earned a name for itself and a Kohler product can always be relied up on. The Kohler K-596-BL Simplice is a combination of innovative design and exceptional ergonomics and functionality.
The Kohler K-596-BL Simplice is a high arc gooseneck faucet with a sleek body and an ergonomically designed curved handle. The spout rotates to 360 degrees proving maximum working space. The pull down spout head's pro motion technology uses a light quiet nylon hose and ball joint to make the spray head use easier and more comfortable. The Dock Nekit technology allows the hose to retract smoothly and secures the spray head tightly to position with the help of a magnet. The spray head can be toggled between stream spray and pause options. It also boasts off the boost technology wherein it can increase the intensity with which the water flows. The boost increases the water flow by a whooping 30%.The angled nozzles form a wide powerful blade of water to sweep your dishes and sink clean with its sweep spray technology. The spray head is equipped with a master clean spray face that prevents building up of minerals on the surface and enables easy cleaning.
The Kohler K-596-BL Simplice has a solid and durable metal construction and leakproof ceramic disc valves. It has a temperature memory which allows you to turn the faucet on and off at a particular temperature set during prior use.
The Kohler K-596-BL Simplice calls for easy installation and the flexible supply lines as well as the installation ring comes with the unit. This is a budget faucet comes in range of $200.
The Kohler K-596-BL Simplice is ADA compliant and has a limited lifetime warranty.
- ProMotion with DockNekit technology for smooth operations
- Boost technology
- Sweep spray
- Ceramic disc valves
- ADA compliant
- Limited lifetime warranty
- Low Flow rate @1.5GPM
- Metal construction
If you really think of comparing the models mentioned in our list of best black kitchen faucets 2020, you would find out that most of them have the latest features and a durability backed by a lifetime warranty that will definitely stand the test of time. All the black kitchen faucets are from reputed companies in which you can rely on completely if you face any problem while use. So basically you are left to choosing the option that suits you or attracts you in terms of the design. Once you have decided on that, any of the above mentioned faucets in out list, would give you a lifetime hassle free experience. So be prepared for the culinary workspace experience you always dreamt off.


text:
Rode i-XYL Stereo Microphone for Apple iPhone & iPad
Sku #J15328000000000
iOS Microphones
- Write a Review
45 day price guarantee, 45 day return policy, 100% secure shopping
Stereo, X-Y pattern microphone for mobile recording on your iPhone and iPad.
The RØDE i-XY is the ultimate recording microphone for iPhone and iPad. With up to 24-bit/96k recording and on-board high-fidelity A/D conversion, your i-XY recordings are rich, smooth and accurate. At the heart of the i-XY is a matched pair of 1/2" cardioid condenser capsules, fixed in a perfect 90-degree near-coincident alignment. This results in immersive and true-to-life stereo recordings, captured in incredibly high detail. Designed and manufactured in Australia, the i-XYL Lightning version supports the iPhone 5s, iPhone 5 and iPhone 5c. A foam windshield is supplied for outdoor recording as well as a reinforced protective zip case to ensure your i-XY is available whenever you need it.
- Record stereo audio at 24-bit, 96kHz
- Matched pair of 1/2" cardiod condenser capsules
- Metal casing for enhanced durability and electromagnetic interference immunity.
- Includes windsheild, zip case
- Software-switchable 72Hz high pass filter for reduction of unwanted low frequency noise.
- iXY-L compatible with iPhone 5, iPhone 5s, iPhone 5c, iPhone 6 and iPhone 6plus
Capture detailed recordings directly from your Apple smart phone or tablet!
i-XYL Stereo Microphone for Apple iPhone & iPad Specifications:
- Acoustic Principle Pressure Gradient
- Capsule 0.50"
- Polar Pattern CardioidPaired cardioid capsules in X-Y stereo pattern
- Address Type End
- Frequency Range 20Hz - 20kHz (selected HPF @ 0)
- Output Impedance 0?
- Maximum SPL 120dB SPL (@ 1kHz, 1% THD into 1K? load)
- Sensitivity -42.0dB re 1 Volt/Pascal (8.52mV @ 94 dB SPL) +/- 2 dB @ 1kHz
- Equivalent Noise Level (A-weighted) 18dB-A
- Weight 40.00gm
- Dimensions 46.00mmH x 55.00mmW x 40.00mmD


text:
James Whitcomb Riley
James Whitcomb Riley (7 October 1849 - 22 July 1916 / Greenfield, Indiana)
» Click to list general statistics » OR, select a date :
The Lugubrious Whing-Whang
The rhyme o' The Raggedy Man's 'at's best
Is Tickle me, Love, in these Lonesome Ribs,--
'Cause that-un's the strangest of all o' the rest,
read more >>
- Hits: Number of visitors who read the poem on the given date.
- Posts: Number of visitors who posted the poem to a friend (via e-mail) on the given date.
- Dates that have "0" hits may not be shown on the list.
- Dates, poems and poets that have "0" hits may not be shown on the list. Statistics are generated daily.


text:
After that Various Events of Sports week started and students of Vidyalaya participated with Full enthusiasm. Some events were also kept for parents. They also participated in various events on the Inaugral Day.
|Moment of March Fast by Vayu House of Vidyalaya
|Band Display by Class VII and VIII students of Vidyalaya
|Chief Guest Dr Bibhas Deb(Former Director of College Development Council AUS) Inspecting the Four Troops
|Moment of MPT presented by Class II and III students of Vidyalaya
|Moment of students participating in the Sports Events
|Moment of Parents participating in the 200M Race


text:
Stop Everything And Watch This!
Kitty was found as a stray and probably didn't have much of a happy life. But you can see that has all changed. YAY! Watch as she happily swings in a kiddie swing, with the cutest doggy smile I've ever seen. D'awwww!
Once-Protected Sea Lions Are Now Being Hunted In The Northwest: Click "Next" below!
Julie Hunt Julie resides in Northern New Jersey with her two kids, two dogs, cat and partner. She has two published books which make excellent trivets if you aren't a fan of poetry. She tolerates people but LOVES animals. If she isn't blogging, she's most likely cuddling with her pups, Paisley and Skyler.


text:
Biofuels research
Research on renewable fuels, particularly biofuels, for use in transport and other sectors.
This publication was withdrawn on
This information is has been removed. Current biofuel research is listed as part of renewable transport fuel obligation.
The Department for Transport commissions research on renewable fuels, particularly biofuels, to ensure that there is a robust evidence base for government policy. This research covers the full life of biofuels from their production, both in the UK and overseas, to their use in vehicles. Details on recent research projects are given below.
'Towards advanced biofuels, options for integrating conventional and advanced biofuel production sites'. This scoping study:
- shows the scale of the opportunity for adapting existing conventional biofuel production sites to advanced biofuel sites
- analysed the potential role of government policy in incentivising conversions
- made recommendations for future areas of research
- Advanced biofuel feedstocks: an assessment of sustainability
Provides analytical framework to assist assessment of advanced biofuel feedstocks to define which feedstocks justify multiple counting.
Feedstock is a raw material used to make biofuels. Feedstocks can include "crops" such as sugar cane, waste or residues such as municipal solid waste and used cooking oil.
- Biofuel effects on diesel performance, emissions and economy in conventional and advanced technologies
This report considers the effects of biodiesel from a number of different feedstocks and blend strengths on the performance of a typical diesel engine and how optimising engine calibration to run on these fuels might change these effects.
Modes research
This suite of research projects investigates the potential supply of sustainable biofuels through to 2050 and the cost and barriers of a range of options for using these biofuels in the transport sector.
- Scenarios for the cost effective deployment of biofuel in the UK road transport sector in 2020
This report presents the key findings of the research. It is strongly recommended that readers begin with this report.
- Assessment of the existing UK infrastructure capacity and vehicle fleet capability for the use of biofuels
This report provides a comprehensive review of the level of biofuel use that is compatible with vehicles and infrastructure, in 2010, across road, rail, aviation and shipping. This work provided input data to the scenarios developed for the main report.
- Development of illustrative scenarios describing the quantity of different types of bioenergy potentially available to the UK transport sector in 2020, 2030 and 2050
This research provides scenarios for the potential supply of sustainable biofuels. The report was designed as input for the main report and is not recommended for use in other contexts.
Note on revisions:
The department intends to update these reports to reflect the latest projections for fossil fuel and biofuel prices. Updated reports, and a further analysis of biofuel use across transport modes over the period to 2050, will be published once these revisions are complete.
- Report on regional level actions to mitigate indirect land use change (ILUC)
- Regional emissions from biofuel cultivation
- Assessing fuel system compatibility with bio-ethanol and risk of carburettor icing
- Investigation into compatibility of vehicles operating on biofuels
- Year 2 supporting studies
- Year 2 of the RTFO (PDF, 2048KB)
- The Carbon Trust: between March 2010 and March 2011 the DfT provided funding to the Carbon Trust to help support the development of biofuels from waste and algae.
- Developing a methodology for greenhouse gas emissions from ILUC for different biofuel
- Feasibility study for a road vehicle biomethane demonstration project
- Amendments to the UK Renewable Energy Directive Art 19(2) report on emissions from cultivation of biofuels feedstocks in the UK
- Year 1 supporting studies
- Year 1 of the RTFO (PDF, 4178KB)
- Methodology and evidence base on the indirect greenhouse gas effects of using wastes and residues and by-products for biofuels and bioenergy (PDF, 830KB)
- Mitigating indirect effects of biofuel production (PDF, 2806KB)
- Appendices
- Advice on the economic and environmental impacts of government support for biodiesel production from tallow (PDF, 727KB)
- The gallagher review of the indirect effects of biofuels production (PDF, 1024KB)
Earlier research
Last updated 16 December 2013 + show all updates
Advanced biofuel feedstocks: sustainability assessment report and presentation released.
First published.


text:
New York Cayman GT4 | NY Exotic Vehicles
For the new Porsche aficionados who have been waiting, the time is now as Porsche offers the Cayman GT4. This extraordinary vehicle is race-ready, with forces both unleashed and controlled in its design. Increased downforce, a mid-engine design for optimum weight distribution, and a 6-speed manual gearbox with dual-mass flywheel and self-adjusting clutch will make the Cayman GT4 at home on your local roads or the track. Unleash its powerful 3.8 liter flat-six aluminum engine, and you have at your command 385 hp and 310 lb-ft of torque, and a top track speed of 183 mph. The engine is protected by a range of technology features, including a variable resonance intake system with switchable flaps, electronic engine management, cylinder-specific knock control, on-demand electronically controlled oil pump, pressure sensor for determining engine load, and on-board diagnostics for monitoring emission controls. A Sport Chrono package with "Sport" button is standard.
The body and suspension of the Cayman GT4 are race-inspired, and use both active and passive designs to maximize performance. Features include Porsche Active Suspension Management lowered by 30 mm, a lightweight spring-strut suspension with front and rear stabilizers, an aluminum structure to provide rear-end rigidity, tire pressure monitoring, and electromechanical power steering with variable steering ratio. Additionally, Porsche uses the Enhanced Porsche Stability Management System for vehicle control that includes antilock brakes, traction control, vehicle stability controls, pre-filling of the brake system, and brake assist. The body of the Cayman GT4 uses an intelligent lightweight construction using aluminum and steel. The rear spoiler is fixed with aluminum wing supports. The windshield has a gray tint at the top, and a water-repellant coating is used on the door windows. Underbody paneling is used to reduce drag. Bi-Xenon headlights in black, tinted taillights with clear lenses, and a specially designed front fascia with integrated daytime running lamps and black surrounds are all standard.
The Cayman GT4 uses Sport Seats Plus with elevated side bolsters, electric backrest adjustment, manual height fore/aft adjustment, backrest shells in silver grey with GT4 logo on the headrests, and available seat heating. A tilt and telescoping steering wheel with leather trim on the steering wheel and gear lever are standard. Two-zone automatic climate control is available. A leather interior with deviated stitching is available. An 18-way adjustable seat with memory is available, as are full bucket seats. Standard electrical and technology features include power windows with one-touch controls, heated windshield washer nozzles, electrically adjustable side mirrors, a 4-speaker CDR audio system with 7-inch touchscreen, universal audio input in the glove box, Bluetooth® hands-free connectivity, HomeLink® programmable door opener, cruise control, and electrical activation of the front and rear luggage compartment lids.
Safety features in the Cayman GT4 are extensive, as would be expected from Porsche engineering. Standard features include 4-wheel disc brakes with 6-piston calipers in the front and 4-piston calipers in the rear, pad wear sensors on every brake pad, electric parking brake, anti-lock brakes, anti-theft system with engine immobilizer, side impact protection system with head and thorax airbags, front dual intelligent airbags, side door beams, and tire pressure monitoring.
Manhattan Motorcars is proud to offer you the Porsche Cayman GT4. Performance, style, and precision engineering offered as a hallmark of Porsche design continues its legacy with the Cayman GT4. Fill out our luxury car finance application online!.
Source: Manhattanmotorcars.com


text:
PEI Potato History
Prince Edward Island was first introduced to potatoes in 1758 when the British took over from the French. An ideal growing place for potatoes the potato harvest was 'a phenomenal success'. Soon, potatoes were being exported to other colonies, and in 1802, Lord Selkirk brought settlers from the Scottish highlands to the Orwell Bay area of the Island. Provided with potatoes to cultivate, the Scots survived almost exclusively on a diet of potatoes and cod for a few years, and by 1806 John Stewart was quoted as saying: 'potatoes are raised in great abundance, and in no country better'.
Faced with land covered almost entirely by a dense forest, the settlers who arrived on Prince Edward Island had to clear land tree by tree to make room for their farms. Often it would take several years to get their fields completely clear of tree stumps. Making as much of their land as they could, they were forced to plant their crops among the stumps while they were still at work clearing out the fields. Because the potatoes took little care or attention, the land owners were free to focus on the development of their farms. In 1822 a man named Walter Johnstone described the potato planting among tree stumps and the piles of soil over the potatoes as resembling 'mole hills'.
In 1805, statistics showed that out of 10,000 acres of farm land on PEI, 15% was devoted to potatoes. This percentage increased over time, and by 1820 over 40,000 bushels of potatoes were being sent as far away as the West Indies. By the '40s this number had increased to 124,000. Exports kept increasing until 1845, when the Island was hit by the same blight that caused famine in Ireland. The modern potato industry in PEI eventually became world famous, beginning in the 1920s after two new varieties of potatoes were introduced: the Irish Cobbler variety and the Green Mountain variety.
In the 1920s, potato acreage in PEI almost doubled, with yields tripling. The beginning of a period
of cooperation between federal and provincial governments resulted in the development of the
seed potato industry and the control of potato diseases. Realizing that with the small size of the
Island, scientists could familiarize themselves with all of its potato farms. This, along with the
Island's cold winters, made disease and pest control and prevention much easier. These
advantages of the Island's size and isolation have resulted in exceptionally high quality potatoes.
Today, no seed potatoes are able to leave the Island without the certification of government
The 1950s brought around the introduction of large-scale mechanization to potato farming on Prince Edward Island. The result: more potato acreage, less individual potato growers. Today, PEI's largest number of the acres used for the cultivating potatoes are found in our area, Prince County (the western part of the Island).
Today, Prince Edward Island ranks first in the production of potatoes in Canada. It grows just over 30% of Canadian production, and is the second largest exporter of seed potatoes in the world. Exported all around the world to places like Argentina, Greece, Italy, Uruguay, Venezuela, and Spain, the Island potato industry is now world famous!
The potato is the foundation crop for Prince Edward Island's agricultural industry. There have been few industries that have left as prominent a mark on the province as the potato industry. Going back to when communities used to gather to help with the potato harvest one farm at a time, the crop and the industry have been a large part of the Island's social structure and identity. In the past it has provided a stable base for the economy and a rallying point for each resident of the province. Most Islanders, if asked to comment on something that we do here that is superior to anywhere else in the world, would be sure to answer with "growing potatoes." The "Northern Vigour" of the crop has made it very desirable all over the world as a seed producer and the quality has made the PEI potato an affordable and nutritious addition to many tables.
There are very few people in the province of Prince Edward Island that are not affected either directly or indirectly by the potato industry. Families and communities depend on the industry for jobs and a source of revenue for those in communities who provide a service or sell goods. The industry is vital to the economy of Prince Edward Island. For example, the processing plant at Cavendish Farms is just below the provincial government in the number of people it employs. In its absence, money from the sale of the crop and incomes from the many aspects of the industry would need to be replaced by another source in order for the province to remain at its current level of prosperity. Capital that is brought to the province from other Canadian provinces and around the world by the sale of seed and table stock potatoes provides the region with an influx of money that would otherwise not be there. When there is trouble in the industry, it is felt throughout every part of the province, not just the agriculture industry. Hard times felt by the potato farmers trickle down to virtually all Islanders.
Although there are far fewer farms than there were in the early days of the industry it still has an impact on as many Islanders. In 1940, there were more than 10,000 growers on the Island whereas in 2002 there were only 550. With modern technology, this comparatively small number of farmers are working three times more land and supplying an industry that employs people from one tip of the province to the other. So, the landscape and look of the industry and the number of people actually farming potatoes has changed, its importance and impact on the Island has only continued to grow.
The potato industry not only provides revenue and jobs to the province, it also gives Islanders a sense of pride and identity. For generations, potatoes have been a part of most Islanders' lives. Each small family farm grew a small crop of potatoes which made it possible for the families to survive by eating the nutritious crop and in some cases even prosper by selling the potatoes that remained after the family had taken what they needed. The huge industry that has grown up around the potato harvest is a very prominent part of Island society. It is celebrated with songs, festivals and many namesake businesses such as "Spud Isle Realty." Islanders rally around performers such as music legend "Stompin' Tom Connors" who celebrated the potato in song with "Bud the Spud." This song describes the export of potatoes from the province and how it is a large robust product unequalled by any other potato-producing region in the world. "And the spuds are big on the back of that rig, and they're from Prince Edward Island."
Potatoes are celebrated at the "PEI Potato Blossom Festival" held in O'Leary, PEI each year in July to mark the time when the potato plants fill the fields in full blossom. The festival has events including the chance to taste recipes, the awarding of "young farmer of the year," the crowning of Miss Potato Blossom, a parade and fireworks. O'Leary is also home to another tribute to the potato industry. The Prince Edward Island Potato Museum celebrates the potato and provides visitors with a broad range of industry-based information and fun. It also boasts the world's largest potato, which stands 14 feet high and is located in front of the museum.
The potato industry has been an intricate part of Island life for generations. It has seen many changes and innovations and caused much worry and turmoil due to various issues related to international trade and scientific scrutiny. The industry has survived many hard times including the same Potato Blight that ravaged Ireland between 1845 and 1851, the Great Depression and two world wars. In recent years, the potato industry on Prince Edward Island has seen some very difficult times. There is not one single culprit that is causing the worry and hard times in the industry. There are many small changes to the industry as well as some large issues that have combined to form the obstacles that have lead to the low demand and low prices for PEI potatoes. These issues range from the new low carb fad diets that have become so popular to new regulations in marketing and selling potatoes, to the loss of markets due to trade disputes with the United States. Regardless of the causes, the industry is feeling the pinch. Potatoes are selling for as little as $1.29 Canadian for 10 pounds with the farmers only receiving little more then $0.50 a bag.
Regardless of what the future brings for the PEI potato industry, there will always be a place in the hearts of many Islanders that takes an immense amount of pride in the achievements of the potato industry on PEI. Many have spent their entire lives working in the industry that is so important to the PEI economy. The industry will always be remembered in song and festival and will have an honourable place in the history of Prince Edward Island.


text:
200 amp Gold contact ANL Fuse
Time-delay sizing for inductive circuits. Small footprint saves space. Window shows limiter status. Common applications: fork lifts, marine, aviation. Isolates faults in equipment systems such as lift trucks and other battery operated systems. Connect to 5/16" studs.
- Maximum Voltage: 32V DC
- Interrupt Capacity: 6000A @ 32V DC
- Ignition Protected (conforming to SAE J1171), safe for installation aboard gasoline powered boats (35-500A Only).
- Gold-plated connector blades for corrosion resistance.
- Visible indication of blown condition.
Payment & Security
Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.


text:
Bowes Mitchell
Bowes Mitchell
Business details
Bowes Mitchell
- Unit 2-3
- The Killingworth Centre
- Newcastle upon Tyne
- Tyne and Wear
- Tel: 0191 268 9000
- Fax: 0191 268 9003
- Web: http://www.bowes-mitchell.co.uk
Location Map
Click here for an interactive map of this location.
About the company
Bowes Mitchell are estate agents and are located at Unit 2-3 in the Tyne and Wear town of Newcastle upon Tyne. Bowes Mitchell can be contacted on 0191 268 9000.
From their website
Find out more from their website. [ disclaimer ]
Our Benton office occupies an extremely busy location at Four Lane Ends. The team at Benton is headed by the company founder, John Mitchell Steele. We are the only agent in the Killingworth Centre and as such have an obvious advantage for owners who previously had no local estate agency.
Additional links
Note: Bizwiki is neither affiliated with the authors of external sites nor responsible for their content.
There are currently no links for Bowes Mitchell.


text:
This AM we're prepping for vacation and I'm trying to cram some studying in (my Operations Management final is tomorrow night, HALLELUJAH) as I listen to Indigo Girls Pandora (I miss those chicks) and chug lemon water. I'm trying to detox from a DISGUSTING breakfast this AM at a local diner. I ordered a combo … Continue reading
Filed under Workouts …
Loose Ends
I realize I've left many loose ends on the old blog of late. First, remember my New Year's Resolutions? Yeah, me neither. If there is one thing I've learned this year, it is this: a woman cannot be expected to set lofty goals for self-improvement when she has a tiny baby/is not sleeping/is dealing with … Continue reading
Weekly Round-Up: So What's New?
Friends! What is up with you guys? I have feel like we haven't connected in ages. Totally my fault. Things have been busy. Luckily, my semester is wrapping up, the office reno is nearly complete (photos upon final completion), and in one week's time I'll have about a month off from grad school. Glorious! So the … Continue reading
Weekly Round-Up: The Sugar Detox Hath Ended
I decided to call the sugar detox yesterday. It was a very fruitful two weeks, but I felt positively awful yesterday. I was sleepy and depressed, a funk I couldn't shake, no matter how much J cleaned (clutter and messiness really take a toll on my mood) or opting for a solo trip to the gym. … Continue reading
Weekly Round-Up: Pour Some Sugar on Me. Please.
Sugar detox: Day 8 (Eight? Can it be?) It's getting a bit easier to avoid the sugars. I took H and A to see Thomas the Train on Friday morning, and I could actually feel my brain synapses light up when I saw the blinking FUNNEL CAKE sign. In another life, I would have happily devoured ALL … Continue reading
Weekly Round-Uppiness
I've decided it is high time to reinstate the Weekly Round-Up, for a myriad of reasons: I need to keep better track of my workouts. I like talking about myself. My weight is a creeper. I'm currently sitting at 144.2; and judging by yesterday's photos, my body is looking about ten pounds heavier than that. … Continue reading
There are so many ideas for this blog swimming in my head at any one time, so much so that today I feel compelled to thank you for reading. I've found a place of joy in writing lately. It no longer feels like a chore, or something I could only undertake when divine inspiration struck. … Continue reading
Weekly Round-Up: Where Do We Go Now?
Welp, it's February 18th, and I've yet to share with you my February resolutions. Spoiler Alert: I have not done ANY of my February resolutions. And why, you may ask? In no particular order: my birthday; out-of-town guests; teething; growth spurts; no sleep; finance class; cramming in moments to study; workouts; cooking; Valentine's Day prep … Continue reading
Weekly Round-Up: Onward.
It's hard for me to begin this week's round-up without mentioning how busy we've been over here at the Orlando Ranch. My MIL and SIL and nephew left last Thursday, after a fun-filled week that unfortunately ended with a bout of a stomach bug. (H, A, and I remain the only men left standing.) With … Continue reading
Weekly-Round Up: DietBet Fin
I just reread the post I started yesterday. Y'all, I am kind of in a bad way. Here's the gist: No time. There's never any time. I don't have time to study! I'll never get into Stamford! I'll let everyone down! I'm so CONFUSED! That's right, friends. My life has taken a Jessie Spano shame … Continue reading


text:
Reposted without permission from here!
Windows Sandbox
Windows Sandbox is a new lightweight desktop environment tailored for safely running applications in isolation.
How many times have you downloaded an executable file, but were afraid to run it? Have you ever been in a situation which required a clean installation of Windows, but didn't want to set up a virtual machine?
At Microsoft we regularly encounter these situations, so we developed Windows Sandbox: an isolated, temporary, desktop environment where you can run untrusted software without the fear of lasting impact to your PC. Any software installed in Windows Sandbox stays only in the sandbox and cannot affect your host. Once Windows Sandbox is closed, all the software with all its files and state are permanently deleted.
Windows Sandbox has the following properties:
- Part of Windows – everything required for this feature ships with Windows 10 Pro and Enterprise. No need to download a VHD!
- Pristine – every time Windows Sandbox runs, it's as clean as a brand-new installation of Windows
- Disposable – nothing persists on the device; everything is discarded after you close the application
- Secure – uses hardware-based virtualization for kernel isolation, which relies on the Microsoft's hypervisor to run a separate kernel which isolates Windows Sandbox from the host
- Efficient – uses integrated kernel scheduler, smart memory management, and virtual GPU
Prerequisites for using the feature
- Windows 10 Pro or Enterprise Insider build 18305 or later
- AMD64 architecture
- Virtualization capabilities enabled in BIOS
- At least 4GB of RAM (8GB recommended)
- At least 1 GB of free disk space (SSD recommended)
- At least 2 CPU cores (4 cores with hyperthreading recommended)
Quick start
- Install Windows 10 Pro or Enterprise, Insider build 18305 or newer
- Enable virtualization:
- If you are using a physical machine, ensure virtualization capabilities are enabled in the BIOS.
- If you are using a virtual machine, enable nested virtualization with this PowerShell cmdlet:
- Set-VMProcessor -VMName <VMName> -ExposeVirtualizationExtensions $true
- Open Windows Features, and then select Windows Sandbox. Select OK to install Windows Sandbox. You might be asked to restart the computer.
- Using the Start menu, find Windows Sandbox, run it and allow the elevation
- Copy an executable file from the host
- Paste the executable file in the window of Windows Sandbox (on the Windows desktop)
- Run the executable in the Windows Sandbox; if it is an installer go ahead and install it
- Run the application and use it as you normally do
- When you're done experimenting, you can simply close the Windows Sandbox application. All sandbox content will be discarded and permanently deleted
- Confirm that the host does not have any of the modifications that you made in Windows Sandbox.
Windows Sandbox respects the host diagnostic data settings. All other privacy settings are set to their default values.
Windows Sandbox internals
Since this is the Windows Kernel Internals blog, let's go under the hood. Windows Sandbox builds on the technologies used within Windows Containers. Windows containers were designed to run in the cloud. We took that technology, added integration with Windows 10, and built features that make it more suitable to run on devices and laptops without requiring the full power of Windows Server.
Some of the key enhancements we have made include:
Dynamically generated Image
At its core Windows Sandbox is a lightweight virtual machine, so it needs an operating system image to boot from. One of the key enhancements we have made for Windows Sandbox is the ability to use a copy of the Windows 10 installed on your computer, instead of downloading a new VHD image as you would have to do with an ordinary virtual machine.
We want to always present a clean environment, but the challenge is that some operating system files can change. Our solution is to construct what we refer to as "dynamic base image": an operating system image that has clean copies of files that can change, but links to files that cannot change that are in the Windows image that already exists on the host. The majority of the files are links (immutable files) and that's why the small size (~100MB) for a full operating system. We call this instance the "base image" for Windows Sandbox, using Windows Container parlance.
When Windows Sandbox is not installed, we keep the dynamic base image in a compressed package which is only 25MB. When installed the dynamic base package it occupies about 100MB disk space.
Smart memory management
Memory management is another area where we have integrated with the Windows Kernel. Microsoft's hypervisor allows a single physical machine to be carved up into multiple virtual machines which share the same physical hardware. While that approach works well for traditional server workloads, it isn't as well suited to running devices with more limited resources. We designed Windows Sandbox in such a way that the host can reclaim memory from the Sandbox if needed.
Additionally, since Windows Sandbox is basically running the same operating system image as the host we also allow Windows sandbox to use the same physical memory pages as the host for operating system binaries via a technology we refer to as "direct map". In other words, the same executable pages of ntdll, are mapped into the sandbox as that on the host. We take care to ensure this done in a secure manner and no secrets are shared.
Integrated kernel scheduler
With ordinary virtual machines, Microsoft's hypervisor controls the scheduling of the virtual processors running in the VMs. However, for Windows Sandbox we use a new technology called "integrated scheduler" which allows the host to decide when the sandbox runs.
For Windows Sandbox we employ a unique scheduling policy that allows the virtual processors of the sandbox to be scheduled in the same way as threads would be scheduled for a process. High-priority tasks on the host can preempt less important work in the sandbox. The benefit of using the integrated scheduler is that the host manages Windows Sandbox as a process rather than a virtual machine which results in a much more responsive host, similar to KVM in Linux.
The whole goal here is to treat the Sandbox like an app but with the security guarantees of a Virtual Machine.
Snapshot and clone
As stated above, Windows Sandbox uses Microsoft's hypervisor. We're essentially running another copy of Windows which needs to be booted and this can take some time. So rather than paying the full cost of booting the sandbox operating system every time we start Windows Sandbox, we use two other technologies; "snapshot" and "clone."
Snapshot allows us to boot the sandbox environment once and preserve the memory, CPU, and device state to disk. Then we can restore the sandbox environment from disk and put it in the memory rather than booting it, when we need a new instance of Windows Sandbox. This significantly improves the start time of Windows Sandbox.
Graphics virtualization
Hardware accelerated rendering is key to a smooth and responsive user experience, especially for graphics-intense or media-heavy use cases. However, virtual machines are isolated from their hosts and unable to access advanced devices like GPUs. The role of graphics virtualization technologies, therefore, is to bridge this gap and provide hardware acceleration in virtualized environments.
More recently, Microsoft has worked with our graphics ecosystem partners to integrate modern graphics virtualization capabilities directly into DirectX and WDDM, the driver model used by display drivers on Windows.
At a high level, this form of graphics virtualization works as follows:
- Apps running in a Hyper-V VM use graphics APIs as normal.
- Graphics components in the VM, which have been enlightened to support virtualization, coordinate across the VM boundary with the host to execute graphics workloads.
- The host allocates and schedules graphics resources among apps in the VM alongside the apps running natively. Conceptually they behave as one pool of graphics clients.
This enables the Windows Sandbox VM to benefit from hardware accelerated rendering, with Windows dynamically allocating graphics resources where they are needed across the host and guest. The result is improved performance and responsiveness for apps running in Windows Sandbox, as well as improved battery life for graphics-heavy use cases.
To take advantage of these benefits, you'll need a system with a compatible GPU and graphics drivers (WDDM 2.5 or newer). Incompatible systems will render apps in Windows Sandbox with Microsoft's CPU-based rendering technology.
Battery pass-through
Windows Sandbox is also aware of the host's battery state, which allows it to optimize power consumption. This is critical for a technology that will be used on laptops, where not wasting battery is important to the user.


text:
The work of FSBA Committees is essential for the Association to carry out its Mission and Strategic Goals. The FSBA Bylaws establish three types of committees: Standing Committees for ongoing action; Ad Hoc Committees to explore topics or issues of special interest; and Nominating Committee to recommend a slate of candidates for FSBA executive officer positions. … Continue reading FSBA Committees
Copy and paste this URL into your WordPress site to embed
Copy and paste this code into your site to embed


text:
Northeastern University – Holographic Imaging Cytometry Program of Excellence
The joint program of excellence between Northeastern University and PHI began in late 2014. Since then HoloMonitor technology has rapidly established itself as a technology of choice for label-free kinetic cellular analysis. The program covers several activities including:
- Establishing a network of collaborators utilizing Holographic Imaging Cytometry.
- Developing novel applications supporting research interests of the Northeastern faculty and students.
- Presenting results at scientific meetings.
- Organizing an annual technology symposium and hands-on laboratory courses.
In May 2017, a summary of the scientific achievements was published in a special issue of Cytometry part A, dedicated to holographic microscopy and quantitative phase imaging.
Read the summary here and view the associated CYTO 2017 presentation here.
Poster Session
Poster session at AACR Annual Meeting 2017. View poster presented by Ed Luther, Supervisor Core Imaging and Cytometry Facility at Northeastern University here.
Ed Luther
Northeastern University
Peer Reviewed Articles and Book Chapters
Applications of quantitative time lapse holographic imaging to the development of complex pharmaceutical nano formulationsSPIE BiOS Conference Proceedings ()Read more
We rely on in vitro cellular cultures to evaluate the effects of the components of multifunctional nano-based formulations under development. We employ an incubator-adapted, label-free holographic imaging cytometer HoloMonitor M4® (Phase Holographic Imaging, Lund, Sweden) to obtain multi-day time-lapse sequences at 5- minute intervals. An automated stage allows hand-free acquisition of multiple fields of view.
Applications of Label-free, Quantitative Phase Holographic Imaging Cytometry to the Development of Multi-specific Nanoscale Pharmaceutical FormulationsCytometry Part A 2017 ()Read more
A review of HoloMonitor applications: tracking of Giant HeLa cells, which may be undergoing neosis tracking the effects of cell cycle related toxic agents on cell lines; using MicroRNAs to reverse the polarization state in macrophages to induce tumor cell killing development of liposomal nanoformulations to overcome multi-drug resistance in ovarian cancer cells and development of dual sensitive micelles to specifically target matrix metalloproteinase 2
Reversal of Chemoresistance in Ovarian Cancer by Co-delivery of a p-glycoprotein Inhibitor and Paclitaxel in a Liposomal PlatformMolecular Cancer Therapeutics ()Read more
The authors created a nanoparticle formulation against chemotherapy resistant ovarian cancer, loaded with the commonly used cancer drug paclitaxel together with a drug that breaks down the resistance mechanism of cancer cells. Using HoloMonitor, the scientists were able to show that paclitaxel-resistant ovarian cancer cells stopped multiplying when treated with the nanoparticles.
Mixed Nanosized Polymeric Micelles as Promoter of Doxorubicin and Mirna-34a Co-delivery Triggered by Dual Stimuli in Tumor TissueSmall ()Read more
Methods for producing 4D plot were developed. Images from the time course were exported to ImageJ and treated as an image stack, creating a volume rendering of the cellular motion over time of analysis. The brightness threshold was adjusted to view all cells within the imaging area or only the thicker cells, a feature that allows identification of mitosis, apoptosis, and transition between mesenchymal and amoeboid cellular morphologies
Enhanced Cytotoxicity of Folic Acid-targeted Liposomes Co-loaded With C6 Ceramide and Doxorubicin: in Vitro Evaluation on HeLa, A2780-ADR and H69-AR CellsMolecular pharmaceutics ()Read more
Using holomonitor M4, it was found that FA-(C6+Dox)-LP treated hela cells underwent rapid progression to apoptosis (cell suicide) after 21 hours, as evidenced by a drastic drop in cell area after loss of cell membrane integrity.
Macrophage Polarization and the Effect of Microrna-155 Administered in Water-in-oil-in-water Multiple Emulsion FormulationsJournal of Clinical & Cellular Immunology ()Read more
Holographic assessment using Holomonitor M4 of the co-cultured cells in real-time showed differences in motility and morphology of macrophages with mir-155 ME treated cells showing greater cellular interaction between the two phenotypes.
Conference Papers and Posters
Comparison of the effects of pharmaceutical compounds on tumor cells in 2D and 3D in vitro models using label-free, quantitative 4 dimensional holographic imagingAACR-NCI-EORTC Inter. Conf. on Molecular Targets and Cancer Therapeutics 2015 ()
Development of a 4-Sample Version of the Kolmogorov-Smirnov Test for Evaluating the Temporal Physiology of Cells Treated with test Compounds in a Label-Free, High Content, Platform for Quantitative Analysis of Adherent Cell-Culture ModelsAACR Annual Meeting ()4-dimensional plots of HoloMonitor time-lapse data were developed to assist in the visualization of the effects of pharmaceutical compounds under development.
A Label-Free, High Content, Moderate Throughput Analytical Platform for Quantitative Kinetic Analysis of Cell Behavior upon Drug Activation Based on the Kolmogorov-Smirnov Test3rd Conference on Impedance-Based Cellular Assays ()
Our objective is to develop multi-functional nanotechnology-based antitumor drug delivery systems for improving efficacy of treatments and reducing undesirable side effects. The essential part of this process is the development of un-biased quantitative analytical techniques. We are reporting a successful validation of a very high content, medium throughput system in multi-well plates, employing the newly developed holographic imaging cytometer HoloMonitor® M4 for label-free time-lapse cellular analysis.
Characterization of macrophage behavior by 4-dimensional label free quantitative holographic imagingAACR Annual Meeting ()
Four dimensional quantitative label-free holographic imaging of the cell cycle in tumor cell linesAACR Annual Meeting ()
Featured Applications
Department of Pharmaceutical Sciences
School of Pharmacy
Bouvé College of Health Sciences
Northeastern University
140 The Fenway, Room 228/229
60 Huntington Avenue
Boston, Massachusetts 02115


text:
Fans of The Walking Dead have started a petition to get showrunner Scott M. Gimple fired.
The petition was triggered by fans getting upset over the decision in season eight to kill off Carl Grimes (Chandler Riggs), son of main character Rick Grimes.
The petition has already amassed 41,637 signatures of its 50,000 goal, and points to rumours that Riggs was treated unfairly by the show.
The description reads: "The entire show has been a lead up to showing Carl become the leader that his father is, maybe one day taking on the mantle himself."
The petition also claims that Riggs considered postponing his college education and had been promised a further three years on the show by Gimple.
They point to a Facebook post written then deleted by Riggs' father which claimed his son was fired two weeks before his birthday.
"Gimple gave no explination as to why Chandler was killed off other than that it was because of 'the story,' and that it had nothing to do with personal issues but many speculate that the claim is false," the petition continues.
"This petition is meant to bring AMC TV into the spotlight and fire The Walking Dead showrunner Scott Gimple for his actions and unfair treatment of actor Chandler Riggs."
They also point out that Carl Grimes is still a leading and pivotal character in the comic book series.
Meanwhile, season eight saw the show's viewing figures slump, drawing below eight million US viewers for the first time in over five years.


text:
(65) firstname.lastname@example.com
FREE LOCAL SHIPPING for product purchases above $150.00
Billington's Unrefined Dark Muscovado Sugar is the world's finest dark brown soft sugar. Its rich taste and natural colour adds depth to all your cooking and baking. Perfect for fruit and chocolate cakes, and adds extra depth to marinades, savoury sauces and chutneys.
RETAIL STOREBlk 10 Haig Rd #01-363/365, Singapore 430010,Tel: (65) 67428388, Fax: (65) 67427545
OPENING HOURSHours: Mon- Sat:9am to 9pm Sun 9am -6pm
Join Us


text:
Welcome. Failte. Willkommen. Vidza Koram. Yo. Chetorochak. Selamat Datang. Huan Ying. Maliu Mai. Emukela. Bienvenue. Alii. Bem-vindo. Vítejte. Üdvözöljük.
You've arrived at our hotel's blog here at SkeabostHotel.com. First of all, thank you for visiting and feel free to look around our website.
In this first post, we would love to share with you few links to our traditional and very active social media profiles, and share our plans for the future of the blog.
We love to be social here at Skeabost House Hotel
The rural nature of our location set us aside from the regular hotels and restaurants you probably pass by every day. Therefore, we do our best to keep our guests updated on what is new at Skeabost. Videos, pictures, posts and all the usual updates are shared around our accounts almost daily.
Here is a list of the social media profiles we regularly use to share information:
- Skeabost Facebook – Here
- Skeabost Twitter – Here
- Skeabost Instagram – Here
- Skeabost Pinterest - Here
- Skeabost Linked In - Here
It's our pleasure to re-tweet, repost and recognize everyone who tags our hotel, or who use one of our favourite hashtags:
- #Skeabost
- #SkeabostBlog
- #SkeabostSunset
- #SkeabostFood
- #WestPier
- #5727Restaurant
- #SkeabostWine
- #SkeabostFishing
- #SkeabostGolfCourse
We also take the privilege to post to your email inbox once a month with the official latest updates from our business. Our newsletter often includes the biggest secrets, discounts, and competitions for our guests. If you haven't yet, make sure you subscribe to our newsletter here.
Another piece of our online activities will be this blog. We love to share stories with our guests and visitors, but the space dedicated to our Facebook, Twitter, and other accounts is limited. The solution was easy - we will write a blog.
Wha is the blog going to be about? Well, let our chefs teach you their favourite recipes, check out the latest pictures from our iGallery, learn about our staff members in "Get to know us" interviews, use our guide to show you around our hotels, find out more about our local suppliers, or join us to see behind the scenes of our beautiful hotel. We have so much to tell you, but if you have anything you would like to know, just ask us here.
Sit down and let us tell you the story
We hope you enjoyed reading this little column of introduction as much as we enjoyed putting it together. If you did, help spread the good word about this part of our website.
See you really soon.
Jakub Bors - Front of House Manager, Skeabost House Hotel - 9/18/2016
All the pictures, graphics, and texts in this blog are original and belong to this website.