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CEA, SAE Reach Understanding on In-Car Standardization
Consumer Electronics Association (CEA) and SAE International announced Monday that they have formed a "cooperative partnership," meant to assist "standardization of vehicle electronics and consumer electronics products to improve the driving experience."
"The integration of consumer electronics products into the vehicle continues to advance," Dave Wilson, vice president, Technology & Standards at CEA, said as part of the announcement.
"From navigation devices to rear-seat entertainment systems to aftermarket products that let consumers equip older vehicles with the latest technology, consumer electronics continue to play a big role in the driving experience. CEA looks forward to working with SAE International to advance our mutual goal of making the driving experience exceptional."


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Update: One or more card offers in this post are no longer available. Check our Hot Deals for the latest offers.
Oh boy! There are a lot of bonus offers right now. If you need a few extra points to top-off your hotel or airline frequent traveler accounts, there are some limited time offers you should know about!
Some of these promotions, like the US Airways 100% bonus, could be a very good deal for folks who would have otherwise paid for a Business Class ticket. In general, I wouldn't buy points or miles unless you had a very specific need or needed to top-off your account for an award.
Others, like Southwest's 40% bonus, are only worthwhile if you're short on points for an award.
You'll get a bonus or discount when you buy miles or points from:
- Alaska Airlines – Up to 35% bonus
- American Airlines – Up to ~56% bonus
- Avianca – 100% bonus
- Flying Blue – Up to 50% bonus
- Hyatt – 30% bonus
- Southwest – 40% bonus
- Starwood Preferred Guest – up to 25% discount
- United Airlines – 25% discount
- US Airways – Up to 100% bonus (targeted)
- Virgin America – Up to 70% bonus
Some of these offers are ending soon. Let's see if they're good deals!
1. Alaska Airlines
Link: Alaska Airlines Buy Miles Promotion
You'll get up to a 35% bonus when you buy miles from Alaska Airlines by December 20, 2014.
You can buy up to 40,000 miles through this deal, and the amount of the bonus depends on the number of miles you purchase:
- 5,000 to 19,000 miles – 20% bonus
- 20,000 to 34,000 miles – 30% bonus
- 35,000 to 40,000 miles – 35% bonus
If you bought the maximum number of miles (40,000), you'd pay $1,100 plus tax and get an extra 14,000 miles.
Including tax, you'll pay a total of ~$1,183 for 54,000 miles, or ~2.2 cents per mile. That's not a terribly good value, but it could be worth it for folks who need to top off their account for an award ticket.
Remember, you can use Alaska Airlines miles for flights on partner airlines, like Delta, Cathay Pacific, and Emirates.
2. American Airlines
Link: American Airlines Buy or Gift Miles Promotion
Until November 30, 2014, you'll get up to a ~56% bonus when you buy miles for yourself or gift miles to someone else. The more miles you buy, the higher the bonus.
You can purchase up to 80,000 miles and get the bonus (but note that American Airlines doesn't allow folks to purchase or receive more than 80,000 miles in a calendar year).
The minimum purchase is 10,000 miles. If you buy the maximum number of miles (80,000), you'll get a 45,000 mile bonus.
This could actually be a very good deal for folks who would otherwise have bought a paid ticket. For example, if you bought the maximum 80,000 miles, you'd get a 45,000 mile bonus or 125,000 miles total. And you'd pay $2,360 plus taxes and a $35 processing fee.
That sounds like a lot of money, but consider that 125,000 American Airlines miles is enough for a round-trip, First Class ticket to Europe, Japan, or Korea. And a paid ticket could cost thousands of dollars more!
So if you were going to spend money on a ticket anyway, it might be worth buying miles through this deal.
3. Avianca
Link: Avianca Buy Miles Promotion
You'll get a 100% bonus when you purchase Avianca miles until December 19, 2014. Avianca is a member of Star Alliance, which means you can use their miles for award flights on Star Alliance partner airlines.
To get the bonus, you must have had an existing Avianca frequent flyer account before November 19, 2014. So you can't sign-up now and get the bonus.
You can purchase a maximum of 75,000 miles through this promotion, and get a 75,000 mile bonus (total 150,000 miles, the most you can buy in a year). Normally, Avianca charges 3.3 cents per mile, so with this deal you'll buy miles for 1.65 cents each. That's not bad!
Folks who might have otherwise bought a paid ticket should consider this promotion. For example, you could buy 50,000 miles (and get a 50,000 mile bonus) for $1,650.
That's enough for a round-trip, First Class ticket to Hawaii on a Star Alliance partner like United Airlines. A paid ticket can cost over $3,800!
So you'd get more than double what you paid for the miles in travel. That's assuming you can find award seats to Hawaii!
4. Flying Blue
Link: Flying Blue Buy Miles Promotion
Flying Blue is the frequent flyer program for Air France and KLM. You'll get up to a 50% bonus when you buy miles until December 31, 2014.
If you buy less than 40,000 miles, you'll get a 25% bonus. Purchases between 40,000 and 75,000 miles earn a 50% bonus.
Normally, Flying Blue sells miles in 2,000 mile increments for 53 euros per 2,000 miles (~$66). That works out to ~3.3 cents per mile (~$66 cost of miles / 2,000 miles). But with this deal you'll pay ~2.2 to ~2.6 cents per mile.
That's not the best value. But this could be a great deal when paired with Flying Blue Promo Awards. Each month, Flying Blue offers award tickets between Europe and certain cities for 25% to 50% fewer miles.
For example, you could get a round-trip, coach class ticket between New York and Europe for 25,000 miles. If you bought more than 40,000 miles, you'd pay 1,000 euros (~$1,243) and get a bonus of 20,000 miles. That's more than enough for 2 round-trip tickets to Europe (with 10,000 miles left over).
But keep in mind that you'll pay taxes and fees on Flying Blue Promo Award tickets. So do the math and see if it's a good deal for you.
5. Hyatt
Link: Hyatt Buy Points Promotion
Hyatt will give you a 30% bonus on purchased points (minimum 5,000) until December 10, 2014. You can buy a maximum of 55,000 points in a calendar year.
Normally, Hyatt sells points for 2.4 cents each. With this deal, you'll pay ~1.8 cents per point, as long as you purchase at least 5,000 points.
This could be a good deal for folks who are planning a paid stay at a Hyatt anyway. For example, you could buy 10,000 points and get a 3,000 point bonus for $240.
That's more than enough for a paid night at a category 3 Hyatt (12,000 points per night), like the Grand Hyatt Tampa Bay. Rooms there can cost over $300 per night!
But remember, you won't always save money buying points for an stay. And award nights aren't always available. So check 1st and do the math before you buy.
Another angle folks might consider exploring is transferring Hyatt points to Southwest if they need additional points for the Southwest Companion Pass.
When you apply for 2 Southwest cards with a 50,000 point bonus, you'll get a total of 104,000 Southwest points including the sign-up bonus and points from minimum spending. But you need another 6,000 points to earn the Companion Pass.
You can get 1 Southwest point for every 2.5 Hyatt points you convert (minimum 5,000 Hyatt points). And you'll get an extra 5,000 Southwest points if you convert 50,000 Hyatt points, or 25,000 Southwest points total.
To get 6,000 Southwest points, you'd have to transfer 15,000 Hyatt points (because the transfer ratio is 2.5 Hyatt points to 1 Southwest point). Through this sale, you could buy 15,600 Hyatt points (including the bonus) for $288. And transfer 15,000 of them to Southwest to earn the Companion Pass!
You'd get ~$86 in travel from 6,000 Southwest points, because their points are worth ~1.43 cents each when redeemed for travel.
So your net cost to earn the Companion Pass through this method is ~$202 (~$288 cost of transferring points to Southwest – ~$86 value of Southwest points).
This could be a good deal if you already have Hyatt points in your account. But it's still cheaper to buy and transfer Choice Hotel points if you use this method to earn the companion pass ($220 to buy Choice points vs. ~$288 to buy Hyatt points).
6. Southwest
Link: Southwest Buy, Gift, or Transfer Points Promotion
For a limited time, you'll get a 40% bonus when you buy, gift, or transfer Southwest points. Normally, Southwest charges ~2.8 cents per point, but with this deal, you can buy points for ~2 cents each.
This is NOT a good deal, because Southwest points have a fixed value of ~1.43 cents each when redeemed for travel.
You'll get the bonus when you transfer points, too. There's a fee of $5 per 500 points transferred, with a minimum transfer of 2,000 points.
I don't usually recommend transferring Southwest points to others because it's easy to book tickets for friends and family from your own account without paying extra fees.
Southwest has a revenue-based frequent flyer program, which means the number of points needed for an award seat depends on the cash price of the ticket. And 1 Southwest point is worth ~1.43 cents when redeemed for flights.
Again, this is NOT a good deal if you're looking to pay for a ticket entirely with points. But if you need a few extra points to top-up your account for an award, this could work well for you.
Note: Purchased, gifted, and transferred points do NOT count towards the Southwest Companion Pass.
If you're looking to save money on a paid Southwest flight, you might get a better deal purchasing a Southwest gift card at an office supply store with your Chase Ink Plus, Ink Bold, or Ink Business Cash Credit Card.
That's because you get 5X Chase Ultimate Rewards points (5% back). And when you register with Visa SavingsEdge, you get an additional 1% statement credit for a $200+ purchase at Staples.
Folks with the AMEX SimplyCash get 5% back at office supply stores in the US.
7. Starwood Preferred Guest
Link: Starwood Preferred Guest Buy or Gift Points Promotion
You'll get a discount of 10% to 25% when you buy or give Starwood hotel points until December 31, 2014. The savings depends on the number of points you buy.
- 500 to 9,500 points – 10% off
- 10,000 to 14,500 points – 15% off
- 15,000 to 19,500 points – 20% off
- 20,000 points (maximum) – 25% off
Starwood points usually cost 3.5 cents each, so with this deal you'll pay between ~2.6 and ~3.2 cents per point. That's not an amazing value, but it could make sense if you're just a few thousand points shy of an award.
Often, it's a better deal to use Starwood points for flights. That's because you'll get a 5,000 mile bonus when you transfer 20,000 points to airlines. So with this deal, you could buy 20,000 points for $525, transfer them to an airline partner, and get 25,000 miles.
That's enough for a domestic round-trip coach class ticket. Often domestic tickets cost less than $500, though, so do the math before you transfer!
However, it could make sense to spend $525 to get 25,000 British Airways Avios points through the transfer. That's because you can use those points for multiple last-minute, short domestic flights that would otherwise cost a lot of cash.
8. United Airlines
Link: United Airlines Buy and Gift Miles Promotion
United Airlines will give you a 25% discount when you buy miles for yourself or someone else until December 31, 2014. The minimum purchase is 2,000 miles, and you can buy up to 150,000 miles per account per calendar year.
Usually, United Airlines miles cost 3.5 cents each. So with this deal, you'll pay ~2.6 cents per mile (plus a 7.5% excise tax).
This still isn't a very good value, but again, folks who are a little short on miles for an award flight might get a benefit from this sale. This is NOT a good deal if you're looking to buy all the miles for an award ticket!
As always, do the math first!
9. US Airways
Link: US Airways Buy Miles Promotion
US Airways is running 2 buy miles promotions. Folks who have the Barclaycard US Airways MasterCard can get up a 100% bonus on purchases of up to 50,000 miles until December 31, 2014.
You'll get a higher bonus when you buy more miles:
- 1,000 to 4,000 miles – 25% bonus
- 5,000 to 19,500 miles – 50% bonus
- 20,000 to 29,000 miles – 75% bonus
- 30,000 to 50,000 miles – 100% bonus
This could be a very good deal if you buy more than 30,000 miles. If you bought the maximum (50,000), you'd get an extra 50,000 miles and pay $1,750 plus 7.5% tax.
That's a very good deal when you consider 100,000 US Airways miles is enough for a round-trip, Business Class award ticket to Europe. You'd get much more value than what you paid for the points!
If you don't have the Barclaycard US Airways card, you can still get a bonus, but it isn't as good. Until November 30, 2014, you can get up to a 56% bonus on purchased miles.
This is the exact same sale as the American Airlines buy miles promotion. If you're going to buy a paid, expensive ticket anyway, this could be a good deal for you.
10. Virgin America
Link: Virgin America Buy and Gift Miles Promotion
Until December 12, 2014, you'll get up to a 70% bonus when you buy points for yourself or others from Virgin America.
The more points you buy, the higher the bonus. The minimum purchase is 1,500 points, and the maximum is 20,000 (not including the bonus):
- Buy 1,500 to 3,000 points – 20% bonus
- Buy 3,500 to 5,500 points – 40% bonus
- Buy 6,000 to 20,000 points – 70% bonus
Usually, Virgin Atlantic sells points for 5.2 cents each. If you bought points with a 70% bonus, you'd pay ~3.1 cents per point.
This is NOT a good deal if you want buy points to pay for a flight entirely, because Virgin America points are only worth ~2.5 cents each when you redeem them for airfare.
But if you need extra points for an award seat, this might be worth it.
Bottom Line
For a limited time, you can get a bonus or discount when you buy (and sometimes gift or transfer) miles and points from the following airlines and hotel chains:
- Alaska Airlines – Up to 35% bonus
- American Airlines – Up to ~56% bonus
- Avianca – 100% bonus
- Flying Blue – Up to 50% bonus
- Hyatt – 30% bonus
- Southwest – 40% bonus
- Starwood Preferred Guest – up to 25% discount
- United Airlines – 25% discount
- US Airways – Up to 100% bonus (targeted)
- Virgin America – Up to 70% bonus
Some of these are NOT a good deal, unless you're just a few thousand miles or points short for an award and need to top-off your account.
But others, like the US Airways targeted 100% bonus, might be a VERY good deal for some.
As always, do the math to see what's best for you before you buy!

subset: commoncrawl


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Everyday, our design department receives a number of emails from our clients containing a variety of attached files. Very often these are text documents and other small files perfectly suited for email delivery. Trouble is graphic files and in particular photographs are a lot bigger in size.
Imagine this… you have to send 35 high resolution pictures of last Monday's product launch to our design department for insertion in the quarterly newsletter. Oh, and don't forget those two strange files you cannot open in your PC with the logos of the sponsors… Are you going to send 20 separate emails so you do not exceed the email capacity of your server?
There are many different solutions, these are two of my favourite:
Dropbox is one of the pioneers of cloud file sharing. Basically, Dropbox allows you to literally create a folder in your computer that is connected and syncronised to dropbox.com online (in the cloud). Any file you drop inside this folder will be copied to the cloud creating a backup. This allows you to login to the dropbox.com site from any computer or mobile device and access these files copied from your computer. Best of all is, any changes you make to any of these files online will be updated in the copies in your computer, hence allowing you to work from anywhere.
In addition to this, you can 'share' any of these files with anyone allowing these people to download them from dropbox.com to their own computer. It only takes a few minutes to setup your free account and install the software. Once this is done, you can share your 35 high resolution images with our designers with just a couple clicks of a button. A really good solution, in particular if you are in a position where you need to 'share' files on a regular basis. And if you, like me, use it so much you run out of memory on the Free Dropbox account, you can upgrade to the professional version for a very affordable fee taking advantage of many other useful features.
This is the ideal solution if you don't need to send large files regularly. This site is extremely user-friendly and has some pretty neat features.
All you need to do is to go to WeTransfer.com, type your email address and your destination email address, then attach the file and click Send. The file gets uploaded from your computer to WeTransfer, which will email you and your friend when the upload is complete, and then they will email you when your friend has downloaded the file.
The benefits for this are that you can do this on any computer, you don't need to sign up for an account, and you can send up to 2 gigabytes of data! Just to put that into perspective, your average email client will only allow you to send about 20 megabytes, which means that WeTransfer can move roughly 100 times more data than regular email!
These are just two of many, all with their pros and cons. I am sure many of you would rather recommend other services. But if you are at a loss on how to send large files, Dropbox and WeTransfer are as good start as any.
We know everyone's multimedia marketing requirements are different, so why not call us to discuss your project. We'll advise you regarding everything from design to delivery, and provide you with a quotation for the full job.
Call us today at 01 4733567 or email at email@example.com for more information about your printing


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The Melting Snowman
The Melting Snowman is a Christmas version of the classic game "Hangman" .
Children remove a snowman part, whenever they make a mistake, until the whole snowman has melted away! You can play it when you want to practise grammar οr vocabulary.
You can also use the melting snowman to practise spelling.
Write down the first letter of the word you want them to spell and draw spaces for the rest.
How to make the snowman:
- Use this link, if you want a simple printable.
- If you want to have a 3D snowman, use foam cups for the body -you can use more than two- and half a foam cup to make the head. If you don ´t like foam cups, paper plates are also great.
- You can also use a white pompom for the head.
- Pipe cleaners can be used for the arms.
- As a hat you can use a sock. Cut the toe off and roll up the cut end.
- Use an orange pompom for the nose. Cut it into a carrot shape, making one side a little pointy. Make a small hole at the foam cup and stick the pompom into it.
- Use tissue paper for the scarf.
- The feet shapes can be drawn on simple paper.
- The eyes and buttons can be made of pipe cleaners – you could either draw them on the cups.
Υοu can also use boxes to make a bigger and more impressive snowman.
A good idea would be to ask your students to make their own craft.
Decorate your class or room with them during Christmas.
You can play this game with one player or the whole class. Ask children to take turns to answer your questions or find the missing letters. If you divide the class into teams, the game will be more challenging. You can revise either vocabulary or grammar.
You can prepare as many flashcards as the parts of the snowman. Here's a split flashcard you can use to revise tenses:
Another alternative of the melting snowman could be the Christmas tree:
It's simple to make it by placing stripes of paper in a row as in the picture above. Nine to ten stripes are enough. Whenever the players make a mistake you take one stripe away.
Want more ideas? Be sure to follow us on Facebook , English Tricks 4U, Pinterest or Scoopit and sign up for emails to keep up with all the latest ideas. You might also enjoy some of our Christmas links.
Free Printable Snowman Countdown to Christmas
I came across this idea for the Snowman Christmas Countdown and thought: Why not make a kid-friendly version printable? So, here it is!
First, you have to print and cut out all the pieces for the snowman.
The printable includes a top hat, a face, a nose and a scarf. It's better to stick them all onto construction paper .You could also decorate the hat with buttons, feathers, and Christmas leaves.
Then, you can assemble the snowman by gluing the hat onto the face and attaching the nose with a brad. If you want to extend the idea, you could draw the body of the snowman. Two big white circles of paper will do.
Want more ideas? Be sure to follow us on Facebook , Pinterest or Scoopit and sign up for emails to keep up with all the latest ideas. You might also enjoy some of our best links.
Have fun!
Merry Christmas !
- The History of Christmas
- Christmas around the world
- Find out how much you know about festive traditions across Europe.
- Preparations for Christmas
- British Christmas
Animated stories
- Journey out of Darkness is a full size 24-page comic book, designed for a 10-14 year old
Advent calendars :
- Advent Calendar – interactive : Click the numbers to get facts around the world.
- A fun Advent Calendar – countdown to Christmas with questions about Christmas celebrations around the world.
- Advent Calendar
- Christmas tree
E- Cards
- Thanksgiving – Ημέρα των Ευχαριστιών
- Αnimated cards
- Elf yourself – Kάνε τον εαυτό σου νάνο
- Dancing Santa – Kάνε τον εαυτό σου ή το φίλο σου Άη-Βασίλη που χορεύει
- Gingerbread Cookie Card
- The Gingerbread Man with Everything
- Create your own snowflake
- Jigsaw – Πάζλ
- Μake a snowman – Φτιάξε ένα χιονάνθρωπο
- Santa sends a letter to your friend – Στείλε κάρτα από τον Άη-Βασίλη στο φίλο σου.
- Design your own Gingerbread House
- Do you want to throw a snowball with your friends?
- Snowman 1, Snowman 2, Snowman 3
- A snowflake maker, snowflake workshop
- Problem solving
- Santa Rider
- Happy Santa
- Help Santa
- Icebreaker
- The Rain Deer Orchestra
- Catch presents: Help Santa catch and pick up presents
School or family party games
Here ´s a party game you can play with children or even parents! All you need are paper plates and pens for each player. The teacher tells the players to put their paper plate on their head.Then the teacher will give a series of instructions for the players to draw on their paper plates (that are on their heads) without looking.
- Here are the instructions:
1. Draw a line for a floor.
2. Draw a Christmas Tree. Add decorations if you feel so inclined.
3. Draw a star on top of your tree.
4. Draw a fireplace with a mantel next to the tree.
5. Draw a stocking hanging from the mantel of your fireplace.
6. Draw a present below the tree.
- After the six steps have been given, let everyone look at their masterpieces. Get ready for a serious giggle fest.Then have players count up how many points they received by following this rubric:
1. 2 points if the tree touches the floor.
2. 2 points if your stocking is touching your mantel.
3. 1 point if your star touches your tree.
4. 1 point if your star is above your tree.
5. 1 point for every Christmas ornament ball that is ON your tree, etc.
6. 1 point if your fireplace doesn't touch the tree
7. 1 point if you actually drew something decorative on your stocking (or something cute, like a tiny kitten peeking out).
8. 2 points if your present is under your tree.
- The player with the most points should receive a really awesome prize
Write your Christmas letter to Santa Claus!
- E-mail Father Christmas
- Christmas lights 2012
- Carol maker
- Top 10 Christmas songs
- Learn English with Christmas songs
- Christmas songs with gaps
Vocabulary games
Christmas Craft
- A christmas tie and an awesome elf hat
- Free printable snowman countdown to Christmas
- PAPADELIgames collection on pinterest
- Christmas tree 1, Christmas tree 2
- Paper Models
- Pencil toppers 1, pencil toppers 2, Kermit, Fozzie
- Santa
- Snowflake
- Snowman
- The best free crafts
- Wreath
Τeacher Resources
- British Council
- Busy sites
- Christmas Eve
- Christmas Day
- Christmas Crafts and Printable Activities
- Classroom Resources
- Lesson plans
- Minute to win it!
- Primary Resources
- TeachersFirst
- Text Snowflake Creator
- Web tools: generate enormous projects about Christmas using various online tools.
Christmas treats for a school party
One of a kind gifts
- Oven mitt filled with spaghetti and sauce
- more ideas


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From Pittsburgh, Pennsylvania, USA:
Can you tell me if having type 1 diabetes will predispose a person to having any of the "antibodies" or "genetic markers" that are found in a person with confirmed celiac disease? I realize the autoimmune aspect of diabetes will increase the risk of celiac disease and other autoimmune disorders, but I am specifically concerned about celiac and diabetes and there being some sort of "crossover" of the serologic markers, either the specific genes or a certain antibody that will be present in both the diabetic patient and the celiac patient due to the autoimmune nature of both diseases.
Also, as a long-time diabetes patient, my son has had A1cs done at least three times a year for 15 years; I have most of these records and the test results range from low 6s to a high-end test of 7.6. His current endocrinologist has classified his care as "overall inadequate control" over his lifetime with diabetes. I thought we were doing a good job; he has no side effects, perfect retinas and has always tested in range for kidney and thyroid function. In your opinion, is this A1c history "inadequate"?
Our understanding about the autoimmune nature of type 1 diabetes and celiac disease suggests that there is an inherited genetic risk associated with the HLA region of our chromosomes. Then, something else, not exactly well defined, must happen to "trigger" this risk and produce damage to the beta cells, the gut lining, the thyroid gland, the adrenal gland, etc. For celiac, we know that this is exposure to wheat/gluten. But, one disease does not cause the others and there is no known overlap with these antibodies except that in a type 1 diabetes population, about 20 to 40% will also have positive thyroid antibodies, about 10 to 20% will have hypothyroidism, about 1 to 2% hyperthyroidism, less than 1% will have adrenal antibodies and Addison's and about 6 to 10% will have celiac antibodies. The overlap is in the genetic susceptibility genes, according to our current understanding. There is some theoretical research that suggests that avoiding cows' milk protein and avoiding wheat/gluten (especially the first 12 months of life) would also decrease (maybe prevent or only postpone) type 1 diabetes, but this is not confirmed research.
I think that you are doing better than average if the A1c values range in the 6 to 7.6 range throughout his diabetes lifetime. However, normal values are 4 to 6% so, perhaps, the comment reflects that fact of our inability to have normal blood glucose values all the time. If you can get to the below 7% range, this will reduce long-term risks further, but this is a difficult task, of course.
Original posting 26 Oct 2006
Posted to Genetics and Heredity and A1c, Glycohemoglobin, HgbA1c
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Last Updated: (none)
This Internet site provides information of a general nature and is designed for educational purposes only. If you have any concerns about your own health or the health of your child, you should always consult with a physician or other health care professional.
This site is published by T-1 Today, Inc. (d/b/a Children with Diabetes), a 501c3 not-for-profit organization, which is responsible for its contents. Our mission is to provide education and support to families living with type 1 diabetes.
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text:
Earth-friendly EOMA68 Computers, Crowdfunding started
This topic contains 2 replies, has 2 voices, and was last updated by lkcl 4 years ago.
hiya folks,
i thought people might like to know that the crowd funding campaign
for modular eco-computers has started here:
the casework for the laptop is 3D-printed and uses bamboo plywood panels.
it is also a GPLv3+ licensed project in its own right.
the schematics and PCB CAD files are available so that you can repair
or improve your own hardware.
there is a lot going on, too much to describe in one message here,
a lot of discussions going on in different places, any questions do
ask me here, happy to help.
that looks interesting! Would love to see laptops become more like that 🙂
thanks dave. well, we need to reach more people, to make it happen – the campaign's live and runs for another 40 days, and we're 1/2 way to one of the critical MOQ quantities (the Computer Card). would you be happy to share a link on your facebook page if i send you something?
You must be logged in to reply to this topic.


text:
Drunken pass in a hotel room ends in domination by a sexy pair of legs Continue reading Sister-in-law's legs (JIMP#64)
Drunken pass in a hotel room ends in domination by a sexy pair of legs Continue reading Sister-in-law's legs (JIMP#64)
Postman meets a hard-wrestling woman and gets more than he can cope with Continue reading A Postman's Lot (JP#14)
Tough men learn a hard lesson when a mature Oriental woman buys their Dojo Continue reading The Dojo of Humiliation (Pantyhose#2)
Man can't keep away from a girl with extraordinary strong legs Continue reading The deadly-legged schoolgirl (JP#10)
Neighbour learns a painful lesson during a heat-wave Continue reading My Sister In-Law and the Bonfire (JP#08)
Mature oriental woman shows men the power of her legs and Kung Fu Continue reading The Legs of the Rickshaw Woman (JIMP#36)
The Goddess Anahita faces the Demon Lord in combat Continue reading Battling the Goddess (JPECHO#05)
The shadow assassins try to take the Goddess Anahita by stealth Continue reading Dancing with the Goddess (JPECHO#04)
Female tribal leader and her daughter demonstrate their fighting skill Continue reading The Maasai Warrior Queen & Her Daughter (JIMP#35)
Sexy mature woman humiliates Jim while a dental nurse brutalises Scott Continue reading The Dental Receptionist & The Kung Fu Nurse (JIMP#34)
And other writings by a Seattle Asian-American guy
The sky is high. The Czar is far.
Comics. Music. Culture.
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comics, pop culture and related topics
a blog sponsored by the MAMA BEARS ORGANIZATION - for more info visit realmamabears.org
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After a wet and blustery start to the weekend, the clouds blew out yesterday evening and today has started bright, clear, and beautifully blue skied. It is also one of those always surprising days when we a cooler than Boone and Floyd. I will probably be out playing catch up on the yardwork after the last few wet weekends.
I saw in the paper that Alberto Gonzales is using an op-ed to try and explain away his responsibility for the mismanagement of his department. I can hardly wait for his testimony in Congress this week…I've just watched the Vice-President of the USA call me irresponsible for I don't know how many times because I disagree with his opinion of how well the administration is doing in running their "War on Terrorism" in Iraq.
Let me get this straight, we are supposed to trust and agree with the people running this administration as they strip the constitutional guarantees we have that protect us against just these kind of people.
Sorry for the rant, I should know better by now than to listen to Cheney or read opinions by the man who approved torture and discounted the Geneva Conventions.
See ya'll tomorrow…


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The Department of Computer Applications (UG) organized an Inagural function with Seminar in Internet Of Things (IOT) on 31st July 2019. The Seminar was presided by the Principal Dr. M.Lekeshmanaswamy and felicitation was given by the Dean-Academics Dr. V.Balasubramaniam and Chief Executive Officer Dr. V.Chinnusamy. The Chief Guest Mr. Naveen .S,Senior Project Engineer, Pantech ProEd Pvt Ltd, Chennai , delivered the Seminar on the topic "Internet Of Things (IOT)". Nearly 225 students from our department took part in the seminar. The technical Session was very informative for the students and many ideas in IOT carriers were given in an effective manner. The students got good exposure in the IOT area. The session was very interactive and the function ended up with the National Anthem.
Events Archives


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First, thank you to everyone who has applied! The first week of January has come to an end and, generally speaking, we feel good about where things are from a processing standpoint (I need to find a big piece of wood to knock on right now).
Those who applied via the Common Application remember well how it works. First, you completed your application and supplement. Then, you "assigned recommenders" – school counselors and teachers – to complete supporting documentation on your behalf. If you used the Wake Forest application, you too may have teachers and counselors who are using an online delivery system to send documentation to us separate from your actual application.
On our end, these documents are accessible in two distinct places. First, we download your application and supplement as this officially starts your "file." While technically two pieces, we try to download them both together. There are times when applicants submit the supplement days or even weeks after having submitted the application – we download such supplements periodically (the Common Application does not allow students to submit a supplement without having submitted an application). We have spent the better part of the last couple of weeks downloading and printing – again, we read applications on paper, not online – your applications and supplements. As noted in the previous post, because of technical issues with the Common Application website on January 1 we will continue to accept applications through Friday, January 10.
Soon we will begin downloading and printing the documents submitted by your "recommenders" – your school reports, transcripts and recommendations. Over the course of the next few weeks, these documents will be populated on your Window to Wake Forest account. Our goal is to have every document, whether submitted electronically or via good old-fashioned mail, entered into our database and added to your physical application file by February 1. As noted in earlier posts, should February 1 come and go and your account not accurately reflect what you or your school submitted on your behalf, please contact our office. We will either assure you that the documents you are inquiring about have successfully arrived or will suggest a secondary method of submitting what is missing.
As I am sure you can imagine, application processing – from putting your materials together to review – is a monumental task. Members of the Admissions Committee pitch in between application reads and other responsibilities to file and assist with data processing. Our support staff is a phenomenal group, often working late or on the weekends in an effort to put your applications together. Thanks to the work of folks like Sue here (who made a mean cornbread for our Polar Vortex Day celebration today!), we will put your applications together for review, one submitted document at a time!
Categories: Admissions
Recent Posts
- August 4, 2020
- July 6, 2020
- June 9, 2020


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Should you want a Blank February 2018 Calendar, then look no more! We provide downloadable Pdf files which are easy to print on just about any printer and match the conventional 8 1/2 x 11-inch sheet of paper. Aside from the February 2018 Blank Calendar, there are numerous calendars for February 2018 supplied. Each schedule has its benefit that serves users with something special. This page is packed with February Blank Calendar 2018 that will enable you in handling daily life tasks and also recall essential occasions of February 2018.
February is the next and brief month of this year with just 28 days in a standard year and 29 days on a leap year. This year, the month is beginning with Thursday and finish on Wednesday. Obtain a printable calendar from under to handle this month at an efficient method. All below recorded February 2018 Calendar Template have been made both for the company and private use. All these Blank February Calendar 2018 are made especially for men and women that have a good deal of work to process. Insert your job or personal details, information at a calendar to keep yourself educated.
Blank February 2018 Calendar
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Get these free calendars in various sizes so that you can get the real essence of schedules utility. We've got lots of templates that work best for making daily, weekly or monthly plans. It depends on yourself that how often do you get time for making plans. If you get some free time, then utilize it, by making plans for the next day. It will surely take you to the next level. If you don't get times on daily basis, then you can try it to plan for week and month. This way you can solve many of your issues.
February 2018 Calendar Blank
This calendar is in landscape design with weekdays beginning with Sundays. The weekdays are alternately greyed out. Therefore, you could write down the jobs which need to be carried out on alternate days. The Blank February 2018 Calendar Printable can be found in three file formats, including DOC, GIF, and PDF. Here you'll discover a printable calendar that's free. Get this editable and Printable February 2018 Calendar Blank to organize your work and private obligations and keep up a great work-life equilibrium. You may place it on your functioning desk so that it will stay before you all of the time. On our website, you receive best and discerning variety of templates to your users you do not need to make much more attempts.
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Hiking day packs
From a half-day in the hills to a day trip with the family, our hiking day packs are full of features to help you stay fast, light and organised on the move.
Our small hiking backpacks, hiking day packs and women's hiking backpacks from 5 to 35 litres are packed with essential features - like walking pole attachments, compression straps, plus front stash and water bottle pockets. The multi-activity Aeon 35 is the ultimate technical day pack; the Tensor 23 is a lightweight hiking backpack for summer hiking; and the Edge 18 is the perfect partner for rapid, quick-grab adventure.
Refine selection
Pack light, burn bright. The Fuse is a lightweight 20L day pack perfect for energetic, action-packed adventures.
Find a spark, stoke your fire. The Ignite is a lightweight 15L day pack for all your fast and light adventures.
With a ventilated breathable back, the AirZone Trail 25 is the perfect hiking backpack for easy day hikes and shorter treks.


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Stocks Erase Gains on Fed's No-Change Decision
September 21, 2015 — Last week, stocks had advanced in anticipation of Thursday's Federal Reserve decision on interest rates, initially spiked higher on the "no change" decision, but 30 minutes later, and through Friday, equity gains evaporated. Before closing out the week with a fractional loss, the S&P 500 had gained 2.7% in the run-up to the decision and had surpassed 2,000 for the first time since August 21st. Fed Chair Janet Yellen said policymakers refrained from raising interest rates because of concerns about slowing and stability in China and other emerging markets. The 9-to-1 FOMC member vote essentially forces investors to live with rate uncertainty until at least October or December when Fed members again debate the merits.
In economic data ahead of the central bank policy meeting, Wall Street took comfort in a second straight monthly gain in retail sales, up 0.2% in August, while July sales were upwardly revised to 0.7% from 0.6%. The Federal Reserve reported that industrial production declined 0.4% last month, also following an upwardly revised July increase (0.9% vs. 0.6% previously reported). On Wednesday, the Labor Department said the consumer price index (CPI) fell 0.1% in August, the first contraction since January. The so-called core-CPI (excludes food and fuel prices), rose 0.1% for a second month. On a year-over-year basis, the headline CPI is up 0.2%, while the core-CPI is up 1.8% since August 2014.
For the week, the S&P 500 fell 0.13%, the Dow Industrials slipped 0.30%, and the NASDAQ Composite gained 0.12%. Five of the ten major sector groups posted gains last week, led by Utilities (+2.53%), Consumer Staples (+0.82%) and Healthcare (+0.76%). Materials (-1.59%) and Telecom (-1.46%) fell among decliners. Treasures prices advanced on safer-haven buying, pulling the yield on 10-year Treasury notes down 5.5 basis points to end at 2.134%.
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Tyler Kord, the co-founder of New York City's No. 7 Sub shops, smokes the French dressing for his asparagus sandwiches over wood chips. This simplified version gets its smokiness from chipotles and smoked salt.
How to Make It
In a blender, combine the ketchup with the mayonnaise, vinegar, mustard, garlic and chipotle. Puree until smooth. Season the French dressing with salt.
In a large pot of boiling salted water, cook the asparagus until bright green, about 2 minutes. Drain the asparagus and spread them out on a large baking sheet to cool.
Preheat a large grill pan. Drizzle the asparagus with olive oil and season with salt. Grill over moderately high heat, turning, until tender and lightly charred, about 3 minutes.
Spread the cut sides of each roll with 3 tablespoons of the smoky French dressing. Arrange the grilled asparagus on the subs and top with the raisins, scallions and crumbled feta. Close the sandwiches and serve.


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On hold.
This is how I have felt my life to be, as of late.
On hold.
I'm not getting any younger, so every moment counts.
On hold.
Outside influences are determined to control my life —
this life — the only one I have.
Give me time to come into my own.
I'm not like you. I need time to process and heal.
It's okay to be me.
I can do this.
Can't I…?
Check out my YouTube channel!
Btw, that's not a booger in my nose.


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Gift Certificates are perfect for last minute gifts or hard to buy for people. They are great for those of us who struggle with gift buying every year (like me). Country Scents offers gift certificates that can be sent by email to anyone.
The gift certificate option is located on the left toolbar of the home page of countryscents.net website. It is not glaringly obvious and I have not been able to change that (not yet). So, I am just reminding anyone who is frantically thinking that Christmas is here! That sort of thing, there are options. I, myself, love to receive gift cards and certificates. They can be used after Christmas when stuff goes on sale. Yea!
Premium members who have created a profile and login earn gift points with every order which may then be converted to a gift certificate! There are a few premium members who have gift certificates waiting for them to use! If you haven't checked lately or placed an order in a while, please check out your profile to find out how many points you have earned and may convert to a gift for yourself or someone else.


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clinical governance
Also found in: Dictionary, Acronyms, Wikipedia.
clinical governanceA framework under which NHS bodies in the UK are accountable for continuously monitoring and improving the quality of their services and safeguarding high standards of care by creating an environment in which excellence in clinical care should flourish. Clinical governance is promulgated by the Commission for Health Improvement.
The 5 Themes of Clinical Governance
(i) Leadership, strategy and planning; identifiable clinical governance lead
(ii) Public and patient involvement
(iii) Quality improvement processes
(iv) Staff focus
(v) Use of information.
The Contractual Components
1) Patient and public involvement
2) Clinical audit
3) Risk management
4) Clinical effectiveness programmes
5) Staffing and staff management
6) Education, training and CPD
7) Use of information to support clinical governance and health care delivery.


text: Great Look Posted on September 7, 2012 by hanaandgeorge 0 With the weather for this weekend set to be fabulous, why not have a weekend of soaking in the sun's rays with a tea party whilst wearing your prettiest skirts and embellished heels? Chic. Happy weekend! {Images: 1, 2, 3} Share this:TwitterFacebookLike this:Like Loading... Related


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"From day one our experience with IQ has been nothing but professional. Their communication is superb, and they are always available when we need them. From implementing WiFi for our entire property to the basics of managing our e-mail database, their team always has a great handle on our projects and completes them quickly and at a high level."
Niki Gross
Managing Director
Whitney Peak Hotel


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I finally got my hands on Yoshi's Woolly World and it's pretty fantastic so far.
Yoshi's Woolly World is probably the most creative game to come out in recent memory. Who would have thought that playing with balls of yarn could be fun?
At the beginning of the game a evil wizard turns all of Yoshi's friends into yarn and carries them away. It's up to the two remaining Yoshi's to save the day and get all of their friends back safe and sound. If you can collect all of collectables while you're on a stage it'll unlock a new Yoshi for you to play as.
I've been trying my best to 100% each stage so I can see every different Yoshi in the game. There are a ton of them to collect and so far I've only gotten about four of them. I'm still on world one because I literally just started playing the game this morning, but from what I've played so far this is one of the best games of the year by far.
The level design is excellent, the controls are great, the enemies are cute, and local co op is a blast. I can beat the crap out of Lunaliah whenever I want. It's more then that though. We can team up and throw each other to some hard to reach locations to collect some hard to get items or knock enemies out. It's fun, and very creative.
The graphics are really impressive. Everything is literally made out of yarn and it's really colorful. Yoshi looks fantastic, and all of the enemies are designed very well. It's also very refreshing from the usual stuff that Nintendo has been giving us lately. Right now I'm having a hard time getting off my Wii U. I've been ignoring everything because of how much fun I'm having with Lunaliah on this game.


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Most years I am not one to make lots of resolutions, but for some reason this year I have two. Superficial as they may seem, here goes: I have resolved to start using all those wonderful 'special' soaps that I have received as gifts! How many times do those lovely and luxurious bars of expensive soap sit in your bathroom waiting for that day when you think it is the right moment to indulge? Well I am waiting no more, I am digging into the special stash of soaps and enjoying a new daily indulgence. (I believe I may have enough bars to last all of 2012!)
BUT, with this being more of a food focused blog, the other resolution I made and would like to share is that I vow to take on the task of trying a new recipe each week. And with the wonderful cookbooks I received this holiday, the hardest part of this task is choosing which recipe to tackle each week.
This week, after flipping through page after lovely page of Plenty and checking in on some of my favorite blogs, I decided on this Brussels sprouts, mushroom and tofu recipe that turned out to be a real winner! Totally satisfying, sweet & spicy, several of my favorite ingredients AND completely doable for a weeknight dinner.
*Notes: My local grocery store did not have shiitake mushrooms so I used portobello. And I did serve this over a bed of baby spinach for some added veggie power! And we have modified the recipe below to include less oil than the version in the cookbook.
Sweet and Spicy Brussels Sprouts with Tofu and Mushrooms
2 tablespoons sweet chile sauce
1 ½ tablespoons soy sauce
1 teaspoon rice vinegar
1 tablespoon maple syrup
3 tablespoons toasted sesame oil
5 ounces firm tofu, cut into ½-inch cubes
1 pound Brussels sprouts
6 tablespoons canola oil salt
1 cup sliced scallions
½ fresh red chile, stemmed, seeded, and diced
1 ½ cups shiitake mushrooms, stemmed and quartered (as mentioned I used portobello)
1 cup cilantro leaves, chopped
1 tablespoon toasted sesame seeds
In a bowl, combine the sweet chile sauce, soy sauce, rice vinegar, maple syrup, and sesame oil. Add the tofu cubes and stir until combined. Set aside.
Trim the ends off the Brussels sprouts, and then cut each piece into three thick slices.
In a large nonstick pan, warm two tablespoons of the canola oil over medium-high heat. Add half of the sprouts, or as many as will fit in one layer. Season with a little salt, and let cook until very well browned, about two minutes. (Note: Only cook the sprouts on one side.) Remove the sprouts with a slotted spoon and set aside in a bowl.
Add a little more oil, and repeat process with remaining sprouts. Set all the sprouts aside in a bowl when done.
Add 2 tablespoons of oil to the skillet and turn the heat to medium-high. Add the scallions, diced chile, and mushrooms. Cook, stirring occasionally, until mushrooms are tender, one to two minutes. When done, scrape the contents into the bowl with the sprouts.
Place the skillet back over high heat. Using a slotted spoon, remove half of the tofu pieces from the marinade and add to the skillet. Reduce heat to medium, and cook until browned all over, about two minutes a side. Transfer tofu to the bowl with the sprouts. Repeat process with remaining tofu pieces.
When all the tofu is cooked, add all of the contents from the bowl back into the skillet. Add the marinade and half of the cilantro. Turn off the heat, and stir well. Let cool down for a minute. Season to taste with salt. Sprinkle with toasted sesame seeds and garnish with the remaining cilantro.


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Example of installing ydpdict on Ubuntu 17.04 LTS using the command sudo apt-get install ydpdict.
Quick installation of ydpdict:
Step 1: Update system:
sudo apt-get update
Step 2: Install: ydpdict
Ater updaing the OS run following command to install the packae:
sudo apt-get install ydpdict
Package Details
|Ubuntu Developers
|Home page:
|interface for Collins and Langenscheidt dictionaries This is an ncurses interface to the Collins English-Polish/Polish-English and/or Langenscheidt German-Polish/Polish-German dictionaries distributed by Young Digital Planet. It can also play the pronunciation samples if the CD is available. . This package is only the interface, it does not contain the dictionary files itself. To use it, you need a copy of a dictionary from YDP.
|Ubuntu 17.04
First of all update your system with the command:
sudo apt-get update
Above command will download the package lists for Ubuntu 17.04 on your system. This will update the list of newest versions of packages and its dependencies on your system.
After downloading the latest package list with the help of above you can run the installation process.
If ydpdict is not installed on your compter then the command 'dpkg -L ydpdict' will give followin error.
deepak@deepak-VirtualBox:~$ dpkg -L ydpdict dpkg-query: package 'ydpdict' is not installed Use dpkg --info (= dpkg-deb --info) to examine archive files, and dpkg --contents (= dpkg-deb --contents) to list their contents. deepak@deepak-VirtualBox:~$
Installing ydpdict:
After system update use the following command to install ydpdict:
sudo apt-get install ydpdict
Above command will confirm before installing the package on your Ubuntu 17.04 Operating System. If you are not already logged in as su, installer will ask you the root password. After completion of the installation you can use the package on your system.
Now we will see the commands for uninstalling the ydpdict from Ubuntu 17.04. For uninstalling this package you can easily use the apt command and remove the package from Linux Operating System.
To remove the ydpdict following command is used:
sudo apt-get remove ydpdict
Following command is used to remove the ydpdict package along with its dependencies:
sudo apt-get remove --auto-remove ydpdict
This will remove ydpdict and all its dependent packages which is no longer needed in the system.
Completely removing ydpdict with all configuration files:
Following command should be used with care as it deletes all the configuration files and data:
sudo apt-get purge ydpdict
or you can use following command also:
sudo apt-get purge --auto-remove ydpdict
Above command will remove all the configuration files and data associated with ydpdict package. You can can't recover the delete data, so, use this command with care.


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También puedes leerlo en:Español
Just like with our anime pages, we also have a wide variety of articles for our manga section as well. From manga recommendations, manga scenes, similar manga and more! When you put down one series, why stop there? Feed your manga addiction further with our articles!
Manhwa is what Manga is to Japan, but from South Korea! This form of storytelling is rich with history and culture, and stretches across many, many genres that anime and manga fans have come to know and love. Find a favorite new manhwa series today!
Fancy reading more about your favorite series but with more information? Check out light novels! If you're looking for more of what you love or another series, light novels are sure to bring you more with their stories and art! Pick up a light novel today and dive into another aspect of the storytelling world.
Each week, Honey's Anime publishes a weekly chart showing the best selling items across a variety of media directly from Japan. Here, you will find the charts specifically related to anime.


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Blog Archives
Girl Rising Documentary
Girl Rising is a global movement to help empower girls through education. In supporting their cause they created a documentary that aims to change the way girls in the world have been stigmatized.
Girl Rising journeys around the globe to witness the strength of the human spirit and the power of education to change the world. Viewers get to know nine unforgettable girls living in the developing world: ordinary girls who confront tremendous challenges and overcome nearly impossible odds to pursue their dreams. Prize-winning authors put the girls' remarkable stories into words, and renowned actors give them voice. The power of story-telling really engages an audience that might be blind to the types of issues girls around the world face. You can view the documentary here, and you can also arrange to have a screening with friends. These stories are ones that need to be shared in order to have productive conversations about what action can be done to effectively empower the next generation of women.


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Upcoming Spanking new Blackberry with Keyboard
TCL announced a pristine Blackberry smartphone for the year 2017. The new Blackberry handset is sued to have the high end uppermost system security.
The newest Blackberry handsets will be aimed to meet these three essential structures:
- Credibility
- Productivity
- Security
The brand new Blackberry mouthpieces are being claimed to have beautiful design and have the distinct features.
Certainly the Blackberry Company is widely held but its reputation lies in the physical Keyboards and the latest one has the keyboard either like its lineage.
The Blackberry Company has not unveiled the Mercury yet. The fascinating device will immediately be recognizable to the sophisticated users of the Blackberry handsets.
The exciting forthcoming blackberry has given a fillip to the market. The features of the upcoming handset are unrevealed yet but the interesting thing to be known about the new blackberry is the presence of fingerprint sensors in the space bar, that's a pretty cool concept.


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Seeing a female lead movie is something much awaited and much needed for Punjabi film industry and that need is fulfilled by none other than the queen of Punjabi movies, Neeru Bajwa.
Trailer of this most awaited movie is out now. It looks amazingly shot movie with so much of emotions. Pankaj Batra is the director of Channo – Kamli Yaar Di and the movie is produced by Neeru bajwa herself with Harry Singh Jawandha.
Complete cast and crew –
Movie : Channo – Kamli Yaar Di
Starring : Neeru Bajwa, Binnu Dhillon, Rana Ranbir, Karamjit Anmol and more.
Directed by : Pankaj Batra
Produced by : Neeru Bajwa, Harry Singh Jawandha
Music : Jatinder Shah
Lyrics : Kumar, Veet Baljit, Vinder Nathu Majra
Written by : Naresh Kathooria
Concept by : Santosh Thite
Music On : Speed Records
Trailer –


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Field of Dreams Rescue
|HomeAnimalsAbout UsContact Us
Field Of Dreams Rescue
Making dreams come true, one paw at a time!
Appointments Available most days*
Located in Vacaville, California
Email email@example.com
*Times available will differ from day to day depending on our work/family schedule.
The latest we offer a appointment when available is 5pm. We are not available later
Please email after 6pm the evening before or the day of that you would like to meet a AVAILABLE dog.
We don't "hold" dogs longer than a same day appointment.
Please also fill out a application on a available dog you are interested in.
Dog Sitting is available for adopted dogs at $20 a day (adopter brings food and crate) when we have space and are home
Thank you!
No appointments available June 7th and June 8th
RegisterThank you for registering with Field of Dreams Rescue. When you submit this form you will be sent a random password. You will then be able to login using the username you enter below and that password.


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Lounge is the main focus of any house. Everyone must specially plan the layout of their lounge or get an interior decorator to make your lounge tidy. When planning remodeling of your lounge, your priority must be the couch or the Sofa for this room. A Sofa must both be fashionable and cozy. It must furnish you and your guests complete relaxation when they come to visit you. Your Sofa must supply you with ultimate coziness. The comfort level of the Sofa must be such that you even like to watch TV lying down on it.
Considering the present time's expectations from a Sofa, the most perfect choice for any home would be a Sectional Sofa which is very much in vogue nowadays. It fulfills all the requirements of high living standards. It impresses the visitors when they look at it and has the ability of turning a depressive and dull living room to an intensely attractive one. At the same time it supplies the required comfort when they sit on it. Sectional sofas are disposable in a large scale of colors and styles. Every design is so eye catching that it is difficult to pick the best. Sectional sofas are made from a variety of materials which scale from leather to fabric of different quality and varying price range.
These Sofas are very appropriate to move from place to place and can be accommodated according to the size of any lounge either big or small. Thus you don't need to be disappointed if your lounge isn't big enough. You can organize your Sectional sofas in any shape; whether it is a square pattern, a circular look or a smart straight line alignment. You can keep on changing the setting of your sofas every time after some months because changes always look good to the eyes. The most outstanding color between all Sectional sofas is red. Red is a very vibrant color and boost passion and enthusiasm.
Definitely you will have no visitors who wouldn't appreciate your decor and the credit for this goes to your selection of Red sectional sofas. Your visitors would surely love the alluring feel of your seductive red sofas. For a very clever combination to improve your room, you can order Red sectional sofas with a black frame complementing with black or chocolate brown curtains and red carpeting. You can also put up a large mirror in your lounge revealing your creativity in the form of red and black glass paints on the borders of the mirror. The loveliness of red color is that it radiates energy. But at the same time red also gives a very welcoming feel. This makes your living room look comfy which you will cherish for years.


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fitted on K(redirected from alignment fit)
fitted on K
Refers to a contact lens in which the back optic zone radius is the same as that of the flattest meridian (or the mean of the two principal meridians) of the cornea. K is a symbol referring to the keratometer reading of the principal meridians of the cornea. Syn. alignment fit. See flat lens; steep lens.


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Guess that changes the meaning of "running hard" doesn't it?!
While I have been running hard lately, in preparation for Angeles Crest 100, it has been the difficult exertion kind of hard.
|Stonewall AS
I've been sneaking in a lot of fun runs with different circles of friends, love seeing everyone running races lately or training for WS, HR or AC. From the Wolfpack up in Idyllwild, to the Badrats at SD100, running all over the AC course with PT extraordinaire Michael Chamoun, the 3 T's with Wendy and Elissa, camping at Guffy with Elissa, Dom, Jesse, Mari and Jorge, running around San Gabriel Peak with Billy... I've been getting after it, running hard, and loving the company. Also enjoyed my solitary run today up to Mt. Wilson and back.
|Allllmost to Telegraph Peak.
|Chamoun on the way to Mt. Wilson, Baldy looming.
|Elissa climbing San Gabriel Peak, Purple Poodle Dog pre-bloom.
|Dom training for HR, Wick for WS and AC for myself.
|Eric, Jesse, Dom - Baldy via Bear Creek


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Ideally situated in the heart of Vermont, the Holiday Inn Rutland/Killington is centrally located with easy, scenic access to Vermont's many historical, cultural, shopping and recreational attractions. Our hotel and its friendly, experienced staff consistently earn the area's highest ratings for facilities and guest service. Experience Rutland's favorite full service hotel, offering more facilities, services and amenities under one roof than any other local hotel. Greenfields Restaurant is open daily for breakfast and serves dinner on the weekends. Seven South Pub serves up your favorite drinks and dinner midweek. Centre Sport has an indoor lap pool, 2 hot tubs and a fitness room. Staying with us you have convenient access to three of the east's best skiing and riding mountains; Killington, Okemo and Pico. Whatever draws you to visit Rutland, Vermont, a piece of history, a taste of the outdoors, a business trip or family vacation, we invite you to sample the flavor of the region, with the Holiday Inn Rutland/Killington as your premier lodging choice.
Amenities· Accessible facilities
· Beauty shop/salon - (In Area)
· Bell staff/porter
· Car rental desk - (In Area)
· Cocktail lounge
· Complimentary newspaper in lobby
· Currency exchange
· Direct dial telephone
· Dry cleaning
· Florist - (In Area)
· Free airport shuttle
· Free parking
· Gift/News stand - (In Area)
· Golf - (In Area)
· Grocery shopping service available
· High speed internet connection
· Housekeeping - daily
· Housekeeping - weekly
· Indoor pool
· Indoor pool
· Interior corridors
· Late check-out available
· Live entertainment
· Lounges/bars
· Meal included - continental breakfast
· Meeting rooms
· Non-smoking
· On-Site parking
· Onsite laundry
· Parking
· Pets allowed
· Restaurant
· Room service
· Safe deposit box
· Sundry/Convenience store - (In Area)
· Tennis court - (In Area)
· Transportation services - local area
· Wireless internet connection in public areas
Room InformationCribs, Wireless internet connection, Free newspaper, Connecting rooms, Color television, Satellite television, Premium movie channels, Pay per view movies on TV, Video games, Air conditioning individually controlled in room, Spare electrical outlet available at desk, Coffee/Tea maker, Microwave, Mini-refrigerator, Ironing board, Separate closet, Desk with lamp, Sofa bed, Bathtub, Hairdryer, Private bathroom, Rollaway bed, Voice mail
2 double beds nonsmoking
2 double beds nonsmoking
2 double beds nonsmoking
1 king bed with pull out sofa nonsmoking
1 king bed with pull out sofa nonsmoking
standard room
standard room
Miscellaneous Information
· American Dollars is the native currency.
· Check in time is 3:00 PM
· Check out time is 11:00 AM
· Time Zone is GMT
· Opened in 1972
· 150 rooms.
· 0 suites.
· 2 floors.
Restaurant InformationGreenfields Restaurant
Greenfields Restaurant offers a varied menu of American favorites. Daily homemade soups and specials, casual atmosphere and friendly service are just part of your experience. Restaurant and Room Service Hours of Operation: Breakfast: Sun 6:30am to 10:Little Harry's
A cozy cafe in downtown Rutland that serves a varied menu of cuisine from the world over.Applebee's
Applebee's is the largest casual dining chain in the world, with locations throughout the U.S. and many countries worldwide. We take pride in having a friendly, welcoming, neighborhood environment for both our staff and guests that makes everyone enjoy thCountry Man's Pleasure Dining and Tavern
Featuring fine Austrian, German and American cuisine served in a casual atmosphere with candlelight and warm open fires, complementing the friendly and efficient serviceNinety Nine Restaurant
An all American casual dining restaurant.Roots the Restaurant
Roots' mission is to create delicious food from fresh, local ingredients. Vermont offers an agricultural bounty of flavorful produce, meat, dairy and other food products that are staples on the Roots menu. Roots is committed to providing affordable mealSevenSouth Taproom
SevenSouth Taproom offers full bar and food service daily with full dinner menu served nightly. Comfortable seating up to 60 people.
Meeting FacilityGovernors Room Chittenden Room Aiken-Proctor Room Aiken Room Proctor Room Vermont Room Frost Room Morgan Room Green Mountain Room Champlain Room Ethan Allen Room
Recreation Information
Fitness center on-site
Indoor pool
Area Attractions- Vermont State Fairgrounds
- Rutland Amtrak Station
Amtrak Ethan Allen Express from Penn Station, New York, NY to Rutland, VT- RUTLAND
- Rutland/Southern Vermont Regional
- Burlington International Airport
- Albany International Airport
- Rutland Country Club
The Rutland Country Club is an 18-hole semi-private golf course with an on site putting green, pro shop, restaurant and caddy shack. Pro Shop: 802-773-3254, Office: 802-773-7061, Cafe: 802-773-9153, www.rutlandcountryclub.com- Proctor Pittsford Country Club
The richly green and flexous fairways pair perfectly with the genuinely soft rolling greens to always keep you a breath behind. Sixty-one well dispersed sand bunkers help to provide an additional challenge to even the most experienced golfers.- Green Mountain National Golf Course
The beauty and design of Green Mountain National Golf Course, voted the No. 1 golf course in Vermont, has an exceptional layout and dedication to service offers a great experience for golfers of all ability levels.- Killington Golf Course
High in the lush Green Mountains of Vermont, discover breathtaking panoramas, azure skies and an 18-hole championship course as exhilarating as the view. Geoffrey Cornish designed this course to take full advantage of the awe-inspiring mountain terrain.- Killington Resort
Spread out over six mountains, Killington Resort offers skiing, snowboarding, mountain biking, golf and much more. Located in the lush Green Mountains, there is something for everyone.- Okemo Mountain Resort
Family operated since 1982 by Tim and Diane Mueller, Okemo Mountain Resort is a year-round favorite for families on the go. Skiing, snowboarding, snow tubing, golf and a great location to see the best of Vermont.- The New England Maple Museum
The New England Maple Museum offers a trip through over 200 years of maple sugaring history starting with the Native American discovery that maple sap cooked over an open fire produces a sweet syrup. Open Mid-March through November.- Billings Farm & Museum
Billings Farm and museum is a working farm, award-winning restored 1890 Farm House and engaging farm life exhibits displayed in 19th century barns, showcase this model farm, a Woodstock landmark since 1871. Open daily May 1 - Oct. 31, Nov & Dec weekends- President Calvin Coolidge State Historic Site
Considered the best preserved presidential birthplace in the nation, Plymouth Notch is virtually unchanged since the early 1900's. Thirteen buildings are open to the public, as are the surrounding grounds and gardens. Open late May Mid-Oct.- Carillon Cruises, LLC
Come aboard the 60 ft . vessel "Carillon", a replica of a Thousand Islands tour boat and set sail with Captain Paul through the pristine waters of Southern Lake Champlain to enjoy scenic beauty, wildlife and American history. Open Mid-May - October.- Quechee Gorge-Vermont's Little Grand Canyon
Enjoy beautiful vistas 168ft. above the Ottaquechee River, have a picnic overlooking the waterfalls or get something to eat at the snack bar. Enjoy hiking or walking the trails along the mile long chasm. Go shopping at the Quechee Gorge Gift Shop.- Trains Around Vermont
Scenic train rides throughout the State of Vermont. Ride and hours of operations vary, please contact Trains Around Vermont or visit their website for more information.- UVM Historic Morgan Horse Farm
Visitors enjoy the beauty of the farm's registered Morgan horses and the French Second Empire Architecture of the historic Main Barn. Come learn about America's first breed of horse and the Vermont State Animal:The Morgan Horse. Open May-Oct.- Vermont Marble Museum
You are invited to discover the world of Vermont Marble at the world's largest marble museum dedicated to this unique material. Quarried from the Green Mountains, our marble has been used in buildings and monuments around the world. Open Mid-May-Oct.- VINS Nature Center
The VINS Nature Center features a state-of-the-art raptor exhibit, housing one of North America's most impressive collections of live raptors including: hawks, eagles, owls, falcons and other birds of prey with daily flight & bird-on-glove presentations.- Hildene, The Lincoln Family Home
Come tour the 24-room home with its original furnishings and personal family effects of Robert Todd Lincoln, son of Abraham Lincoln. Also, enjoy the formal gardens, newly restored cutting and kitchen gardens, walking trails and rotating exhibits.


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Peter Werth Autumn 2012 Collection
Channelling classic British style, the latest menswear collection from Peter Werth manages to incorporate both vintage and consciously modern notes to form a unique character that embodies the ethos behind the brand.
The collection is grounded in timeless pieces – suits, jackets and knitwear form a classic foundation that, with the appropriate layering, could create an outfit for any weather. The majority of the outfits shown in the lookbook feature traditional shirt and blazer combinations paired with separate trousers for an everyday, smart look that creates an easy template for solid, simple style.
There is a strong vintage influence within the collection, with corduroy and flannel being teamed with dogtooth patterns and gingham checks for a textured, aged aesthetic. However, this vintage styling is contrasted with modern detailing. Asymmetrical buttoning on shirts and colour block techniques give the collection a contemporary appeal, whilst geometric patterned knitwear bridges this divide by harking back to classic patterned pieces whilst still maintaining a modern edge.
The collection is notable for the way it dresses down smarter pieces in order to make them more accessible for younger customers – sweatshirts replace knitwear, which is typically seen under smart casual blazers, with bomber jackets and parkas also prevalent. Emblematic of this attitude is the collection's flannel trousers – coming in a classic jeans cut, the brand have renovated a piece that is conventionally thought of as 'stuffy' and a little old fashioned.
Overall, Peter Werth's current collection draws from both the classic and the contemporary to create a range that reflects the brand and the style of the current modern man.
Available At
Peter Werth 2012 Collection:


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Clearly I have a sweet tooth, so when a roommate offered me these yummy treats I couldn't resist. I'm pretty sure eating these made my day.
Gummy bears are so freaking cute! Am I the only weird one that pretends the bears are alive and makes them walk around and talk? And then of course I eat them… nom nom.
Regular gummy bears come in pretty colors and are deliciously chewy and sweet. The chocolate coating adds an interesting variety by blending two of my favorite things together. If you are in the Rhode Island area, you can find these chocolate covered gummy bears at Goodies by the Sea.


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|Each student wrote down one thing they learned from the lesson that they can use to foster a growth mindset.
This year I did my first lesson a little different than in the past. I decided to lead with the concepts of growth mindset, grit & goal setting--these go along with my theme for the year, "Get your Mind Right," and align with my program goals.
I wrote a little about this idea earlier in the summer here.
I aligned the lesson plan with the new ASCA Mindsets & Behaviors for Student Success and Common Core. I taught the lesson to every student through their English classes. I also put a link to the Prezi on my program website so students who were absent would be able to watch it, the voice overs help to keep my auditory learners engaged. Thankfully I only had about 8 students absent throughout the 2 weeks I delivered the lesson.
I had each student take "Short Grit Scale" which I will grade and give back to them all next week in their Advisory Homerooms. They will take the assessment again at the end of the semester, after they set their own SMART goals, then again at the end of the year. We are working towards improving their over all grit score by individual and by grade; we expect every student to have a grit scale score of 3 or above.
Students who struggle with writing SMART goals, or have a low beginning grit scale score will be placed into my Vision Board small group during RTI time. Read more about this idea here.
Best wishes as you kick off your school year!


text: Volume 17.09 | Mar 7 Issue 17.09 March 7, 2016 Publications | Reviews | Science | Policy | Business | NIH | CBER | Events | Jobs TOP STORY New Method for Producing Heart Cells May Hold the Key to Treating Heart Failure Scientists discovered how to make a new type of cell that is in between embryonic stem cells and adult heart cells, and that may hold the key to treating heart disease. These induced expandable cardiovascular progenitor cells can organically develop into heart cells, while still being able to replicate. When injected into a mouse after a heart attack, the cells improved heart function dramatically. [Press release from the Gladstone Institutes discussing online prepublication in Cell Stem Cell] Press Release | Full Article | Graphical Abstract PUBLICATIONS (Ranked by impact factor of the journal) Dendritic Cell Vaccines Based on Immunogenic Cell Death Elicit Danger Signals and T Cell–Driven Rejection of High-Grade Glioma Researchers combined dendritic cell (DC) immunotherapy with immunogenic cell death induced by hypericin-based photodynamic therapy. In an orthotopic high-grade glioma (HGG) mouse model involving prophylactic/curative setups, both biologically and clinically relevant versions of immunogenic cell death-based DC vaccines provided strong anti-HGG survival benefit. [Sci Transl Med] Abstract | Press Release Silencing of Anti-Chondrogenic MicroRNA-221 in Human Mesenchymal Stem Cells Promotes Cartilage Repair In Vivo In vivo, the potential of microRNA-221 (miR-221) silenced human mesenchymal stromal cells was investigated by first encapsulating the cells in alginate and then by filling a cartilage defect in an osteochondral biopsy. After implanting the biopsy subcutaneously in nude mice, they found that silencing of miR-221 strongly enhanced in vivo cartilage repair compared to the control conditions. [Stem Cells] Abstract CRISPR-Cas9 Targeting of PCSK9 in Human Hepatocytes In Vivo The authors used a clustered regularly interspaced short palindromic repeats (CRISPR)–CRISPR-associated 9 genome-editing system to target the human proprotein convertase subtilisin/kexin type 9 PCSK9 gene in chimeric liver-humanized mice bearing human hepatocytes. [Arterioscler Thromb Vasc Biol] Abstract Autologous Transplantation of Intestine-Isolated Glia Cells Improves Neuropathology and Restores Cognitive Deficits in β Amyloid-Induced Neurodegeneration Scientists showed that the autologous transplantation of enteric glial cells into the brain of β-amyloid-injected rats arrested the development of the disease after their engraftment. [Sci Rep] Full Article Intralymphatic mRNA Vaccine Induces CD8 T-Cell Responses that Inhibit the Growth of Mucosally Located Tumors The authors demonstrated that E7-TriMix mRNA vaccine-induced CD8+ T lymphocytes migrate into the tumor nest and control tumor growth, although they do not express mucosa-associated markers such as CD103 or CD49a. [Sci Rep] Full Article BMP7 Enhances the Effect of BMSCs on Extracellular Matrix Remodeling in a Rabbit Model of Intervertebral Disc Degeneration Researchers investigated the efficacy and feasibility of stem cell therapy using bone morphogenetic protein (BMP)-7-transduced bone marrow mesenchymal stem cells (BMSCs) to promote extracellular matrix remodeling of degenerated intervertebral discs. [FEBS J] Abstract Opposing Effects of Sca-1+ Cell-Based Systemic FGF-2 Gene Transfer Strategy on Lumbar versus Caudal Vertebrae in the Mouse Investigators compared the osteogenic effects of stem cell-based FGF2 therapy on red marrow-filled lumbar vertebrae with those on yellow marrow-filled caudal vertebrae of young adult W41/W41 mice. [Gene Ther] Abstract CD19xCD3 DART Protein Mediates Human B-Cell Depletion In Vivo in Humanized BLT Mice Administration of the CD19xCD3 DART protein resulted in a dramatic sustained depletion of human CD19+ B cells from the peripheral blood, as well as a dramatic systemic reduction of human CD19+ B-cell levels in all tissues analyzed. [Mol Ther Oncolytics] Full Article REVIEWS Biologics for the Treatment of Autoimmune Renal Diseases The authors discuss the key molecules that direct injurious inflammation and the biologics that are available to modulate them. The opportunities and challenges for the introduction of relevant biologics into treatment protocols for autoimmune renal diseases are also discussed. [Nat Rev Nephrol] Abstract Stem Cell Therapy: A Promising Biological Strategy for Tendon–Bone Healing after Anterior Cruciate Ligament Reconstruction From commonly investigated bone marrow-derived mesenchymal stem cells to emerging anterior cruciate ligament-derived CD34+ stem cells, multiple stem cell types have been proven to be effective in accelerating tendon–bone healing. The authors describe the current understanding of tendon–bone healing and summarize the current status of related stem cell therapy. [Cell Prolif] Abstract Visit our reviews page to see a complete list of reviews in the cell, gene and immunotherapy research fields. SCIENCE NEWS Compugen Presents Results for CGEN-15029 Immuno-Oncology Therapeutic Program Compugen USA, Inc. presented results for CGEN-15029, the lead internal program in the company's immuno-oncology therapeutics pipeline. [Press release from Compugen USA, Inc. discussing research presented at Emerging Approaches to Cancer Immunotherapy, New York] Press Release Top-Line Data from All Patients on the Primary Endpoint of Kiadis Pharma's Phase II Trial with ATIR101™ Selected for Oral Presentation Kiadis Pharma N.V. announced that key data from the company's ongoing single-dose Phase II clinical trial with its lead product ATIR101™ has been selected for an oral presentation to discuss the top-line data. [Press release from the Kiadis Pharma N.V. discussing research to be presented at the 42nd Annual Meeting of the European Society for Blood and Marrow Transplantation (EBMT), Valencia] Press Release bluebird bio to Present Clinical Data on Lenti-D in CALD in Plenary Session bluebird bio, Inc. announced that interim data from the ongoing Phase II/III Starbeam Study for the treatment of cerebral adrenoleukodystrophy (CALD) will be presented in an oral presentation. [Press release from the bluebird bio, Inc. discussing research to be presented at the American Academy of Neurology (AAN) 2016 Annual Meeting, Vancouver] Press Release Advaxis Study in Head and Neck Cancer Selected for Late-Breaking Poster Advaxis, Inc. announced that data from a Phase II study of its lead Lm immunotherapy candidate in HPV-associated head and neck cancer, axalimogene filolisbac (AXAL), has been selected as a late-breaker poster presentation. [Press release from Advaxis, Inc. discussing research to be presented at the 2016 American Association for Cancer Research (AACR) Annual Meeting, New Orleans] Press Release Omalizumab Decreases Colds in Inner-City Children with Asthma, NIH Study Reports Treatment with omalizumab significantly decreases the number of colds in inner-city children with allergic asthma, researchers reported at a press conference. [Press release from National Institute of Allergy and Infectious Diseases discussing research presented at the American Academy of Allergy, Asthma and Immunology (AAAAI) 2016 Annual Meeting, Los Angeles] Press Release POLICY Coalition Pushes Federal Government for $500-Million Investment in Stem Cell Cures Is half a billion dollars too big a budget ask to cure chronic conditions such as diabetes, heart disease, multiple sclerosis and Parkinson's that account for the bulk of Canada's health care costs? It's a tantalizing prospect for a strained healthcare system, and one a private-sector led coalition suggests is within reach if the Trudeau government, health charities and industry join forces in an unprecedented $1.5-billion national effort to exploit Canada's strengths in stem cell science, cellular therapies and regenerative medicine. [Research Money Inc.] Editorial Republicans Promise 'Sustained' NIH Funding Hikes without Budget Gimmicks The two legislators with arguably the most clout over the budget of the National Institutes of Health (NIH) promised to give NIH "at least" the $1 billion increase that President Barack Obama has requested. [ScienceInsider] Editorial Indian Scientists Decry Spending Plan Science spending in India is slated to rise 11% in the 2016–17 fiscal year to $1.19 billion, according to the budget proposal presented by the government of Prime Minister Narendra Modi. [ScienceInsider] Editorial Italian Scientists Protest 'Serious Neglect' of Research Fed up with their country's politicians, Italian scientists have launched a national debate about the dire state of their country's research system. They want the government to reverse years of budget cuts and prevent increasing numbers of researchers moving overseas for work. [ScienceInsider] Editorial How the US CRISPR Patent Probe Will Play Out There is no shortage of optimism about the scientific potential of CRISPR–Cas9, a technique that can precisely alter the genomes of everything from wheat to elephants. But there is a great deal of confusion over who will benefit financially from its use. On 10 March, the US Patent and Trademark Office will begin an investigation into who deserves the patent on using CRISPR–Cas9 to edit genes. [Nature News] Editorial From our sponsor: Learn how to form and isolate neural rosettes more efficiently. Watch the video. BUSINESS CEL-SCI Reports Monthly Patient Enrollment in February for Its Phase III Head and Neck Cancer Trial CEL-SCI Corporation announced that during the month of February it has enrolled 27 patients in its ongoing Phase III trial of its investigational immunotherapy Multikine in patients with advanced primary head and neck cancer. [CEL-SCI Corporation] Press Release Baxalta Commences Phase I Clinical Trial of BAX 826, the Company's Second Extended Half-Life Factor VIII Treatment for Hemophilia A Baxalta Incorporated announced that it has dosed the first patient in its Phase I, first-in-human clinical trial of BAX 826, a recombinant Factor VIII treatment for hemophilia A that uses proprietary polysialic acid technology to extend its circulating half-life. [Baxalta Incorporated] Press Release miRagen Therapeutics Initiates First Clinical Trial for MRG-106 in Lymphoma Patients miRagen Therapeutics, Inc. announced that it has initiated a Phase I clinical study of its anti-cancer product candidate MRG-106, a synthetic microRNA antagonist of microRNA-155. [miRagen Therapeutics, Inc.] Press Release Celyad Receives the First US Patent Covering a Method of Producing Allogeneic TCR-Deficient CAR T-Cells Celyad announced the issuance of United States Patent No. 9,273,283 relating to a method of producing allogeneic primary human T cells that are engineered to be T-Cell Receptor (TCR)-deficient and express a chimeric antigen receptor (CAR). [Celyad] Press Release Merck, Pfizer and Verastem Announce Combination Trial of Avelumab and VS-6063 in Ovarian Cancer Merck, Pfizer and Verastem announced that they have entered into an agreement to evaluate avelumab, an investigational fully human anti-PD-L1 IgG1 monoclonal antibody, in combination with Verastem's VS-6063, an investigational focal adhesion kinase inhibitor, in patients with advanced ovarian cancer. [Verastem, Inc.] Press Release SELLAS Life Sciences Announces FDA Orphan Drug Designation for WT1 Cancer Vaccine in Patients with Malignant Pleural Mesothelioma SELLAS Life Sciences Group announced that the U.S. Food and Drug Administration (FDA) granted orphan drug designation for the company's WT1 cancer vaccine for the treatment of patients with malignant pleural mesothelioma. [SELLAS Inc.] Press Release Wills Eye Hospital Treats 1st U.S. Patient in New Gene Therapy RESCUE Trial Wills Eye Hospital announced it has treated the first RESCUE trial patient in the United States enrolled in an FDA-approved gene therapy vision research study. [Wills Eye Hospital (PR Newswire Association LLC)] Press Release Cancer MoonShot 2020 Community Oncology Milestone: National Immunotherapy Coalition (NIC) Partners with New England Cancer Specialists to Advance Cancer Care in New England Cancer MoonShot 2020 announced its clinical affiliation with New England Cancer Specialists (NECS), aimed to greatly expand patients' access to advanced cancer care, innovative clinical trials, and survivorship resources in the community. [Cancer MoonShot 2020] Press Release FDA Accepts Supplemental Biologics License Application (sBLA) for KEYTRUDA® (Pembrolizumab) in Advanced Non-Small Cell Lung Cancer Merck announced that the U.S. Food and Drug Administration (FDA) has accepted for review a new sBLA for KEYTRUDA®, the company's anti-PD-1 therapy, to include data from KEYNOTE-010. [Merck Sharp & Dohme Corp.] Press Release NIH National Cancer Institute; Notice of Meeting (FR Doc. No: 2016-04671) Center for Scientific Review; Notice of Closed Meeting (FR Doc. No: 2016-04446) National Institute of Allergy And Infectious Diseases; Notice of Closed Meeting (FR Doc. No: 2016-04361) CBER Donor Screening Recommendations to Reduce the Risk of Transmission of Zika Virus by Human Cells, Tissues, and Cellular and Tissue-Based Products EVENTS NEW Stem Cell Summit 2016 April 25-27, 2016Boston, United States Visit our events page to see a complete list of events in the cell, gene and immunotherapy community. JOB OPPORTUNITIES NEW Postdoctoral Fellowship – Adeno-Associated Virus Gene Therapy (Icahn School of Medicine at Mount Sinai) Scientist – Human Pluripotent Stem Cell Neural Differentiation (STEMCELL Technologies Inc.) Postdoctoral Fellow – Hematology/Oncology (Boston Children's Hospital) Postdoctoral Fellowship – Stem Cells, Oligodendrogenesis and Remyelination (UC Davis) PhD Positions – Cancer, Microbiology and Stem Cell Engineering (Virginia Commonwealth University) PhD Positions – Tendon Repair and Regeneration (NUI Galway) PhD Position – Leukemogenesis and Treatment Resistance (Institute for Tumor Biology and Experimental Therapy) Postdoctoral Positions – Gene Regulation and Translational Cancer Research (University of Texas Health Science Center) Postdoctoral Position – Hematology/Oncology (Penn State College of Medicine) Postdoctoral Fellow/Research Associate – Cancer Therapy (Memorial Sloan Kettering Cancer Center) Translational Research Scientist – Hematology/Oncology (University of Chicago) Staff Scientist – Cell Therapy Process Development (Fred Hutchinson Cancer Research Center) Postdoctoral Research Fellow – Cell Cycle Control and Tumorigenesis (Fred Hutchinson Cancer Research Center) Recruit Top Talent: Reach more than 60,000 potential candidates by posting your organization's career opportunities on the Connexon Creative Job Board at no cost. SUBSCRIBER TOOLS: Profile Center | Connexon Publications | Article Submission | Contact Us


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Digging Into Pixels: Radiogenomics Extracts Meaning
Seeking a non-invasive approach to cancer diagnosis and prognosis
In a radiological image, a tumor's edges might appear fuzzy or crisp; its shape could range from oval to many-lobed; and its density and texture might vary across the tumor. To determine whether and how those characteristics matter, researchers in the new field of radiogenomics are extracting as much information as possible from every pixel and correlating it with gene expression and cancer survival rates.
The work has the potential to increase our understanding of tumor biology and offer patients personalized medicine based on both imaging and genetics.
The field now seems poised to take off, says Robert Gillies, PhD, chair of cancer imaging and metabolism at the Moffitt Cancer Center in Tampa, Florida. "The whole idea of extracting large amounts of quantitative data from images has been around for a long time, but it's taken a while for the computational power to catch up with us," he says.
Shades of Gray
In radiogenomics (also known as radiomics), researchers convert images to mineable data in high throughput, Gillies says. So the radiologist's "fuzzy edge" becomes a numerical descriptor, reproducible between physicians using the same rating scale or calculated by a computer based on the arrangement of pixels in shades of gray.
Radiomics data come in a few flavors, such as semantic and computational, says Sandy Napel, PhD, professor of radiology at Stanford University. Semantic features are word descriptors, such as round, oval or star-shaped, assigned by a human. Computational features are numerical values calculated from pixel patterns.
For example, one way to describe a tumor's "texture"—whether it's mostly uniform or mottled in density—is for computer software to compare the intensity of each pixel with those of its neighbors. The more alike the intensities are, the less textured and more homogeneous the tumor. By changing the parameters of the analysis, a computer can describe texture in numerous different ways, Gillies says.
He's using imaging features, such as density and contrast, to study the tumor microenvironment. Tumors can have a strong or weak blood supply from the vasculature, which shows up as a high or low perfusion of injected contrast agents on an MRI. And they can be more or less dense, which appears as high or low contrast with surrounding tissues. Gillies wants to classify tumors—in brain, breast, lung and connective tissue—based on which microenvironments are present, and correlate that score with patient data such as treatment and survival.
Eventually, Gillies hopes radiologists will build databases of tens of thousands of patient images. A radiologist could log on with a picture from today's patient; compare it to images from patients past; and predict, based on those past patients' clinical histories, the best treatment options.
Images Plus
Beyond simply correlating images and clinical data, radiogenomicists can mix in molecular information, such as a tumor's genetic mutations or gene expression profile. Normally if physicians want to know about the biochemistry and gene expression in a tumor they need a physical piece of it. But that same information may be buried in the medical images obtained noninvasively—if researchers can figure out how the cancer's molecular biology influences the pictures they see.
In a 2012 paper in the journal Radiology, Sylvia Plevritis, PhD, associate professor of radiology at Stanford, together with Napel and other colleagues, showed it could be done. The team examined CT scans and gene expression profiles from 26 people with lung cancer. They compared the gene expression data with 180 different image descriptors, both semantic and computational. Because the participants were newly diagnosed, with no data available on survival or relapse, the researchers looked for correlations between gene expression and prognosis in a public database. Combining those two analyses, they found that tumor size, shape and edge sharpness were most strongly linked to gene expression that correlated with prognosis.
For example, tumors that include air-filled structures, called internal air bronchograms, often upregulated a gene called KRAS. And KRAS overexpression, according to public databases, is an indicator that a tumor will likely recur. Other studies have offered conflicting results as to whether internal air bronchogram is a positive or negative sign, so more research is necessary. However, this and other correlations in the paper suggest the potential value of imaging in making prognoses.
Plevritis cautions that this was a small proof-of-principle study. "It just says that we should do more, and we are," she says. The team has recruited around 75 new lung cancer participants so far, and is also looking into similar studies with breast and liver cancer.
With large enough datasets, computers might pull out tumor features that humans would never notice, Napel says. "The technology is here; it could be implemented today," he adds. But there are logistical challenges. For one, data acquisition is not standardized across different institutions: Some use different slice thicknesses for 3-D images, or apply different filters. Similarly, no standardized methods exist for how people or computers convert those images into comparable, numerical data.
Other obstacles include time and money. Radiologists' schedules are already full simply reading scans; they have no time to develop a new way of doing their business, Gillies notes. What's needed, he says, is a "sandbox" where radiologists can experiment with information technology to build annotated image databases. He estimates the price tag for a single center like that at $17 million—and there would need to be many such centers. Storing and moving the petabytes of data would cost a fortune, Napel adds.
But, Gillies points out, misdiagnosis due to incorrect scan interpretation is also costly. If computers could assist in diagnoses and prognoses, and catch human errors, he predicts the new methods would be "more than cost-effective." And similar techniques could be useful in radiology and pathology image analysis beyond cancer, Napel says.
"I certainly don't propose replacing radiologists with computers, but we need to incorporate them as allies," Gillies says.


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- Photo Details
- Caption: Jacqueline Bisset During the 2008 Afi Fest Centerpiece Gala Screening of Che, Held at Grauman's Chinese Theatre, on November 1, 2008, in Los Angeles. Photo: Jenny Bierlich - Globe Photos
- Celebrity:
Jacqueline Bisset,
Grauman's Chinese Theatre
- Event:
Archival Pictures - Globe Photos - 25828
- Image Number: 1487557
- Dimensions: 1632x2464 px
- Photographer: Globe-Photos
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