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Friday, 16 October 2015
Christmas Friday...
Well its back to Christmas Friday as I try to get back on track from all the recent shows!
Today's card is again using stamps to die for I seem to have gone on a little bit of a stamping track this week! I stared by stamping the Shaded poinsettia onto a clear velum with perfect medium. I then heat embossed these with Silver Shine detail embossing powder from Cosmic Shimmer. I cut these out with the matching Classic Poinsettia die and made up the flowers in three sizes by using 2 of each size to make a single poinsettia. I added silver dazzlers in the centre of each flower just to make them more realistic.
To make the card to match the flowers I embossed a piece of coconut white card using the Holly Trellis A4 embossing folder. I rubbed over the surface with pewter gilding and polished it up with a dry wet wipe ( this gets off the darker shade and leaves the shine behind)
Next I cut 2 of the snowflake borders in black foundation card and again added the gilding wax to highlight the embossed areas. I stock these to a strip of card so that they faced away from each other. I covered the card strip in the centre using seam binding which adds another texture.
This is a complex looking card but really is simple to do!
Creative Expressions Craft dies by Sue Wilson
Snowflake Border, corner & tag set
Snowflake background
Classic poinsettia
Shaded Poinsettia stamp to die for set
Coconut white & Black foundation Card and white velum
Silver shine embossing powder
Pewter Gilding wax
P.s. The winner of this weeks card Giveaway is Culliesocks! If you email me your address to firstname.lastname@example.com I will post this straight out to you x
61 comments:
Morning John, this card is absolutely gorgeous I love everything about definately one I will doing for Christmas thanks for all the inspiration don't know where we would be without you Sue and Julia.ReplyDelete
Nancyd xx
Hi John.ReplyDelete
A beautiful card Thank you.
Take care Kitty.
Hi JohnReplyDelete
another stunning card love the colours and dies thank you tracyw
another stunnerReplyDelete
Hello John, this card is an absolute wow, Love the poinsettias. Have a great day. BxReplyDelete
Good morning John, wow I've just said blue and white are my favourite colours forReplyDelete
Christmas cards but black and white is another : )
Congratulations to the winner!!!
Have a good one!!!
Loopy Lynda xxx
Good morning John this is a stunning card the poinsettias are gorgeous. Have a great day today. Hugs JackieReplyDelete
Morning John, hope it's a good one wherever you are.ReplyDelete
I love this card it's gorgeous. I do love the snowflake edge die. It's so versatile.
Another must make for me, I've ordered the poinsettia stamp so hopefully will have that this Saturday. Along with all the other Creative expressions stuff I've ordered.
I'm supposed to be cutting down on my buying of craft stuff, but you keep showing me more that I need lol.
Have a great day
Morning John, another cracker, love the monochrome cards, and the way you have done the flowers, you showed us this on Hochanda a little while ago and I liked it then. Congratulations to Culliesocks on winning the card, you will love it.ReplyDelete
Stay safe, healthy and happy, hugs, June Smith xxx
Stunning card, love the snowflake border.ReplyDelete
Another smashing cardReplyDelete
Luv Rach :)
Oh, this is just gorgeous! A wonderful design. The poinsettias look so beautiful. Congratulations to the winner of your card. Debra xReplyDelete
What a beauty, i love it !ReplyDelete
Elaine H X
Another really lovely and 'classic' card.ReplyDelete
Hi John,ReplyDelete
Incredibly beautiful!!!
Lorna D
Hi John. This is a real beauty. The vellum flowers are gorgeous along with the lovely border die cuts. Have a good weekend. Take care xReplyDelete
Hi John you have made a stunning card today .Thank you Gloria(Sidcup) xxReplyDelete
Beautiful, you've done yourself proud with this one John...love itReplyDelete
Stunning, classy and elegant, a beautiful card, John, and a very achievable look.ReplyDelete
B xx
A beautiful card, John - love the poinsettias.ReplyDelete
Anne (Northampton)
Hi John,ReplyDelete
A stunning card, I love the way that you have used the border and the poinsettias are gorgeous, I have the dies and stamps and have had a go with them on vellum and they are so beautiful.
Thanks for sharing,
Heather Treble
- Anonymous16 October 2015 at 09:45
Good morning John I wouldn't think of black and white for Christmas but this is so effective love from Jackie xxReplyDelete
Morning John, A stunning card, gorgeous flowers, I love it !!ReplyDelete
Congratulations to the lucky Culliesocks.
Lots of love from Patricia xx
Morning John,ReplyDelete
Gorgeous card, a great design and lovely poinsettias.
Another gorgeous card John. Love the poinsettias stamped out of vellum, it produces such delicate flowers. I like the use of black and white it is very elegant.ReplyDelete
Hi John. Lovely card. I especially like Sue's snowflake border dies. SueL xReplyDelete
Like the layout, can be adapted to other occasions (I don't do Christmas)ReplyDelete
Hi John, beautiful, elegant card today. Love the silver and black together and the Snowflake border and tag die are gorgeous and my favourites. I haven't got them yet but I'll wish very hard in the hope that one day I will....! :) "Thank you John" and congratulations Culliesocks! Wonderful! :) xx Love Karen xxReplyDelete
Wow wow wow lovely card, I am going to try the poinsettia flowers today.ReplyDelete
Carfty hugs Pen x
What a beautiful card. I have the snowflake border but wouldn't have though of using it like that. Your poinsettias are gorgeous too! You are so talented.ReplyDelete
Gorgeous and very elegant. The poinsettias look as if they're made of organza! I'd feel very special if someone made me a card like this at Christmas.ReplyDelete
Tonbridge Sue
A superb card, so many technques, stunning....luv Ursula xReplyDelete
A superb card, so many technques, stunning....luv Ursula xReplyDelete
Hi JohnReplyDelete
A Truly Elegant, Opulent, Rich, Beautiful Card And I Have The Components To Put This Together, I'm Looking Forward To Watching You Once Again On Hochanda You Share So Many Wonderful Tips And Techniques I'm Also Watching Julia Today I Loved Phill's Shows Also.
Congratulations To Culliesocks
Hugs From Sam xxx
HI John what a lovely card, just love the way you have used the border die. a stunning card.ReplyDelete
Congratulations to Culliesocks
I really like the look of this card. It is very nice.ReplyDelete
Since I discovered you from Sue's blog, I must say, your cards are also beautiful and amazing. This card just knocked my socks off (as we say in the states). IT IS GORGEOUS!!!ReplyDelete
Hi John,ReplyDelete
you do have a way with borders! Your cards are great John and really enjoyed you on Hochanda.
I was going to try for the Creative Expressions design team but time got the better of me. work work work!!!
Great stuff John,
Anne M xx
Eh up JohnReplyDelete
I don't think this looks complex, which is why it is so appealing.
A gorgeous look that is achievable with relatively very little.
Love it!
Ang x
Ps.......congratulations Kate on winning one of John's beautiful cards.
Hi John,ReplyDelete
Another stunning card, I love that border thanks for sharing.
Congratulations to Culliesocks xx
Linda xx
Thisis gorgeous John, you could sendit to me any day.ReplyDelete
congratulations to Culliesocks.
love Val x
John, only one word: FANTASTIC ! ! ! ! Greetings from Germany, ClaudiaReplyDelete
Hi john,ReplyDelete
You've given us another beautiful card, that snowflake border and the poinsettias are divine.
I love it.friends
Best wishes , Rose
Hi john,ReplyDelete
You've given us another beautiful card, that snowflake border and the poinsettias are divine.
I love it.friends
Best wishes , Rose
Hello John, another stunning card today. I love the black and white theme na the dies are sooo beautiful.ReplyDelete
I am delighted to have won one of your beautiful cards, thank you so very much, Kate x
Hello John,ReplyDelete
Stunning, delicate and I love it.
Congratulations to Culliesocks - lucky lady.
love, Maureen xxx
Absolutely beautiful John. I bought the Classic Poinsettia at AP I must get the matching stamps now and keep practising!ReplyDelete
This card is so lovely, John.ReplyDelete
Love, Love, love it.
I am going to try this one!!!
This card is so lovely, John.ReplyDelete
Love, Love, love it.
I am going to try this one!!!
card is lovely John ,Laura OReplyDelete
I have to hold my hand up and admit that I have copied this card, I was showing it to my teenage Grand daughter and she loved it and asked if I could make one for her to give to her best friend at Christmas, I don't have the stamp yet so just altered the flowers slightly, but it did look beautiful. So thank John for your inspiration. Linda.ReplyDelete
Great card today John.ReplyDelete
Love Nancy xx
OH Wow John I absolutely adore this one, it is just so gorgeous.ReplyDelete
The poinsettias look so pretty in the silver.
I am definitely going to make this one.
Ohhh how gorgeous! Wish I could make something as beautiful as this card.ReplyDelete
The poinsettias are gorgeous. Love the whole card.ReplyDelete
Hi John, that is a beautiful Christmas card an the poinsettia is gorgeous. Take Care Melody xXxReplyDelete
Stunning card John, quite dramatic. Your poinsettias are lovely and go beautifully with the snowflake border. Pat xReplyDelete
Gorgeous card John !ReplyDelete
Maria x
Really love that one John, and the poinsettias are so beautiful.ReplyDelete
Wow! This is stunning John, as were yesterdays, so beautiful.ReplyDelete
Love & hugs
Jacquie J xxx
Hi John,ReplyDelete
Only one word for this STUNNING!
Love Janet x
from Wakefield


text: Supplementary Data from Multi-objective control in human walking: insight gained through simultaneous degradation of energetic and motor regulation systems Kirsty A. McDonald Joseph P. Cusumano Peter Peeling Jonas Rubenson 10.6084/m9.figshare.9730742.v1 https://rs.figshare.com/articles/journal_contribution/Supplementary_Data_from_Multi-objective_control_in_human_walking_insight_gained_through_simultaneous_degradation_of_energetic_and_motor_regulation_systems/9730742 Minimization of metabolic energy is considered a fundamental principle of human locomotion, as demonstrated by an alignment between the preferred walking speed (PWS) and the speed incurring the lowest metabolic cost of transport. We aimed to (i) simultaneously disrupt metabolic cost and an alternate acute task requirement, namely speed error regulation, and (ii) assess whether the PWS could be explained on the basis of either optimality criterion in this new performance and energetic landscape. Healthy adults (N = 21) walked on an instrumented treadmill under normal conditions and, while negotiating a continuous gait perturbation, imposed leg-length asymmetry. Oxygen consumption, motion capture data and ground reaction forces were continuously recorded for each condition at speeds ranging from 0.6 to 1.8 m s−1, including the PWS. Both metabolic and speed regulation measures were disrupted by the perturbation (p < 0.05). Perturbed PWS selection did not exhibit energetic prioritization (although we find some indication of energy minimization after motor adaptation). Similarly, PWS selection did not support prioritization of speed error regulation, which was found to be speed-independent in both conditions. It appears that during acute exposure to a mechanical gait perturbation of imposed leg-length asymmetry, humans neither minimize energetic cost nor speed regulation errors. Despite the abundance of evidence pointing to energy minimization during normal, steady-state gait, this may not extend acutely to perturbed gait. Understanding how the nervous system acutely controls gait perturbations requires further research that embraces multi-objective control paradigms. 2019-08-26 09:26:01 energetics locomotion multi-objective control prioritization motor regulation

subset: commoncrawl


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Vegetables, Upset
If there's one thing all those ice pickers and puddle jumpers on the East Coast have going for them, it's a rocking après-ski club scene. For the past couple years, one of the hottest acts in skidom has been Boston's Angry Salad. After a year touring with the likes of Cowboy Mouth, Vertical Horizon, and the Samples, these surly greens are returning to the Northeast ski circuit with their power pop fine-tuned to shake the timbers. Singer-songwriter Bob Whelan and company cull the best of '70s rock, punk, and folk on their self-titled major-label debut (on Blackbird/Atlantic); and on stage they blast through those tracks and add some great covers. Insist on Nena's "99 Red Balloons."
"There's a beautiful shotgun effect about playing the ski clubs," says Whelan of the band's annual blitz up I-93 and beyond. "The crowd is stoked from the slopes, it's snowing, and the wine is flowing." Veterans of the road, the band can bring the lights down low or blow the walls off. Look for them and other great ski bands like Fighting Gravity and the Pat McGee Band at places like the Snow Barn (Mount Snow), Bumps (Sunday River), Gallagher's (Sugarbush), and the Wobbly Barn (Killington).
Disc of the Month
THE KILLINGTONS, The Killingtons (Meg)
The Killingtons have nothing to do with the ski resort in Vermont, but this album is worth checking out anyway. Hailing from Long Beach, California, these guys play brawny, sweet-and-sour guitar rock, and they lay it on thick and slow like Sunny Day Real Estate, or like the Deftones on Valium and Twinkies. Lead singer JK (K for Killington, apparently¿hence the name) Thompson takes the edge off the guitars with his clear, plaintive tenor, and the full band frequently kicks into a soaring ballad mode that's downright relaxing.


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Hardcore music is a lot like a pineapple. It has a tough exterior, but is actually very sweet on the inside. The Ghost Inside is no exception to this. Their music is aggressive and allows you to unleash all of your rage along with Jonathan Vigil's growling vocals and Aaron Brooks' relentless riffing and maddening breakdowns, but at the same time their lyrics have always been honest and meaningful. The Los Angeles based band's new album Dear Youth is a poignant outpour of real emotion, captured in mosh-worthy hardcore anthems.
Dear Youth is based on a letter vocalist Jonathan Vigil wrote to his younger self, and the lyrical content follows in the same vein. The track "Move Me" proclaims life and then proves it with two-step inciting guitarwork and shout-along lyrics: "with my back against the wall, I stack brick by brick, I will rise above them all like this."
"Mercy" is the epitome of a good hardcore song from start to finish. With punchy riffing, a catchy chorus, and an earth-shattering breakdown—there is no doubt that this track will send crowds into a state of rage when played live.
If you're in the mood for a quick and dirty, angry, fast-paced pick me up, "Wide Eyed" is the track for you. The three-and-a-half minute song is engaging all the way through, even featuring guest vocals from Epitaph labelmates letlive.'s Jason Butler.
Dear Youth is an entirely solid hardcore album, loaded with memorable musical gems. The Ghost Inside is without a doubt one of the most consistently great hardcore bands, and this new album is just further proof that they can still write mosh-provoking and meaningful music.


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Umeå University in northern Sweden has a student union that is now fighting accusations of sexism after a raucous dinner party organized by business students last weekend.
Girls posing in their underwear, a student licking chocolate sauce from a a girl's body and pole dancing were just some of the vivid images that have emerged from a dinner party organized for male students.
Well, I've seen worse things in my student days and the only thing I haft to say about it is that I hope that the females organize something similar with male strippers etc. That is actually how it usually goes, something media refuse to write about. 'Quid pro quo' - usually one part of the union or a certain collection of students hire or bring in girls/boys from another and then they switch.
However, I hope Sweden's Justice Mentalist isn't reading about this. Lots of letters to be sent out, lots of suspects to be outed by name, age, address and phone number in this mess. And maybe there were drugs involved? She needs to send in the cops to do proper anal cavity searches and after that she can lock them all up. Oh, and she don't have a degree herself, need to punish those smarter than her. Can get messy(ier).


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Found 3 results in 8 milliseconds.
Supply chain management as a field has grown from early roots in logistics to become a strategically important business function. This conversation takes a look at recent trends that have dominated su
During this webinar Professor Thomas Johnsen (PhD, HDR) speaks about "Supply Chain Management Practices for COVID-19 Crisis and Beyond". Learn more about the MSc in
iAdvize, a pioneer start-up company in human resourcing commerce based in Nantes welcomed IMM students following "Entrepreneurship and Innovation" elective run by Claire Champenois. Studen


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Azerbaijan Is Not Israel's Secret Staging Ground
A recent article in Foreign Policy gets Israel's relationship with my country wrong.
I was most surprised to read a very provocative and unsubstantiated article by Mark Perry in your publication ("Israel's Secret Staging Ground").
The author arrives at wide ranging allegations based on unnamed sources and rather convoluted commentary. Clearly upset about Azerbaijan's friendly relations with Israel, Perry, for some reason, equates a historic friendship between the Azerbaijani and Jewish people into preparing for a war against Iran.
This unreasonable accusation makes no sense in terms of geography — Azerbaijan doesn't border Israel and contradicts the clearly stated policy of Azerbaijan not to allow use of its territory against any neighbor. In fact, Azerbaijan's commitment to promoting regional peace has been demonstrated by its involvement in the ongoing talks with Armenia for the last two decades in spite of the latter's illegal occupation of the internationally recognized Azerbaijani lands.
Perry's article is an interesting piece of fiction. Whether it was driven by a special political agenda or vivid imagination, your publication seems as an odd choice for such speculative writing.


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La Trobe Law's Recent International Mooting Success
Adding more international accolades to its mooting program, La Trobe reached the quarter finals at both the 2010 Vis International Commercial Arbitration Moot in Hong Kong and the 2010 Frankfurt Investment Arbitration Moot Court in March.
These successes added to La Trobe's excellent performances at these moots in 2009 when La Trobe Law School Mooting Teams won the Frankfurt Moot and placed equal third in the Vis Moot.
The Vis Moot, which is a simulated legal proceeding requiring both written and oral advocacy, is the most prestigious private international law moot in the world. This year's competition included student teams from 76 universities representing some of the most well regarded law schools from continental Europe, USA and Asia. In addition to reaching the quarter finals the La Trobe team captain, Harlis Kirimof, received an honourable mention for his oral advocacy.
The Frankfurt Moot has established itself as a key competition on the international mooting calendar. This year the La Trobe Team competed against eminent law schools such as George Washington Law School and the City University of Hong Kong. La Trobe has reached the finals of this competition for the last three years.
These results consolidate La Trobe's international reputation as a law school which moots at the highest levels. Our international mooters have developed excellent written and oral advocacy skills, they have learnt the value of team work and they have networked with lawyers, judges and academics from Australia and all around the world.


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Director, Advisory
KPMG Australia
Praveen Thakur is a Director in KPMG's Management Consulting group. He has over 15 years' consulting experience advising clients on transport and urban planning, policy and economics. Praveen has advised on major transport projects such as Melbourne Metro, WestConnex, Perth Freight Link, Perth Light Rail and Western Interstate Freight Terminal. Praveen led KPMG's team advising Infrastructure Victoria on the 30-year infrastructure strategy.


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I mentioned in a recent post that I'd participated in a webinar about dimensions of creativity. In this post I'd like to share some of what I walked away with. (Not surprisingly, it involves the use of some web 2.0 tools to foster creativity.)
photo © 2007 Brian Hillegas | more info (via: Wylio)
J.P. Guilford in the late '50's created a model for divergent thinking and the webinar trainer drew upon this work for our session. In particular we were introduced to the following terms : fluency, flexibility, originality, and elaboration. Fluency in this context refers to the first step in creative problem-solving, the generation of lots of ideas. Flexibility involved the ability to look at a task from different points of view, to try different approaches. Originality means creating something unique, unusual, or unexpected, and elaboration refers to the ability to embellish and add details to a very general task. Our trainer suggested using this vocabulary with our students, especially around projects. She recommended tuning into kids' strengths early on and using the rubrics to differentiate and encourage growth in particular dimensions when appropriate.
Take aways for me:
1. Brainstorm everything! Activate prior knowledge whenever possible and generate lots of ideas to build fluency. Web 2.0 tools well suited to this include: wordle, scribblar, and bubbl.us.
2. Look at assignments flexibly. Consider shifting the time period used, or the persona involved, or the point of view. Allow for different modalities to show evidence of learning. Tools to aid with flexibility include Voicethread, Glogster, and the Guess-the-Google game.
3. Students often lose their originality early on in an attempt to be teacher pleasers. Cheer and applaud their original ideas whenever possible.
4. Prompt originality with juxtapositions. (e.g. What did the Boston Tea Party sound like?) Web tools that foster originality include: bookemon, Google Search stories, bookr, Glosgster, and Voicethread.
Of course the challenge for me will be to propose some different sorts of assignments to my teachers when approached about research or tech integration. But that is our responsibility to our students if we want them to become active, creative producers of information and ideas, not just consumers.


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This is an archived article that was published on sltrib.com in 2013, and information in the article may be outdated. It is provided only for personal research purposes and may not be reprinted.
Utah native Dick Motta, former Utah Stars center Zelmo Beaty and current Jazz broadcaster Ron Boone are among 31 candidates who have been nominated for induction in the Naismith Basketball Hall of Fame. Also nominated, according to NBA.com, are nine-time All-Star Gary Payton, Chicago Bulls owner Jerry Reinsdorf and former league executive Russ Granik. The nominated candidates now move forward in the process. A nine-member panel will review their credentials and decide who becomes a finalists. Seven votes are necessary to advance. Then, finalists must receive 18 votes from the 24-member committee for induction into the Hall of Fame.The Class of 2013 will be revealed at the Final Four in Atlanta in April. Born in Midvale, Motta coached at Weber State and in the NBA for 25 years. He helped build the expansion Chicago Bulls into a contender in the 1970s and later won an NBA championship with the Washington Bullets. This is Motta's third straight year as a Hall of Fame nominee.Boone spent five seasons with the ABA's Utah Stars. He also played in the NBA with the Kansas City Kings, the L.A. Lakers and the Jazz.At the time of his retirement, Boone owned the record for most consecutive games of any player in the history of professional basketball 1,041 in the ABA and NBA. His record was later broken by A. C. Green. However, Boone played at least 20 minutes in each game while Green made several token appearances during his streak because of injuries.Like Boone, Beaty played on the Utah Stars' ABA championship team in 1971.He retired in 1975 with combined ABA-NBA totals of 15,207 points and 9,665 rebounds.According the NBA.com, the entire list of nominees from the North American committee: John Bach, Dick Bavetta, Gene Bess, Maurice Cheeks, Jack Curran, Bobby Dandridge, Lefty Driesell, Bill Fitch, Cotton Fitzsimmons, Travis Grant, Tim Hardaway, Spencer Haywood, Robert Hughes, Kevin Johnson, Marques Johnson, Gene Keady, Bernard King, Guy Lewis, Danny Miles, William (Speedy) Morris, Dick Motta, Curly Neal, Payton, Rick Pitino, Mitch Richmond, Paul Silas, Eddie Sutton, Jerry Tarkanian, Rudy Tomjanovich, Paul Westphal and Gary Williams.Reinsdorf and Granik are candidates through the Contributor category that also includes, among 21 candidates, Al Attles, Marty Blake, Harry Glickman, Del Harris, Red Klotz (former Baltimore Bullets point guard best known for running the Washington Generals), Jerry Krause, Johnny Most, Gene Shue and Donnie Walsh.
Steve Luhm


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Personal injuries that occur on the property of hotels can sometimes happen because of the negligence of the hotel owners who may be held responsible. However, not all injuries can legally be considered the fault of the hotel. West Virginia residents should be aware of all of the factors involved in filing a personal injury claim.
The long-term impact of concussions in West Virginia
A study of 43 athletes conducted by a group from St. Michael's Hospital in Toronto found that the impact of a concussion may be seen months or years after it occurs. The study looked at the brains of 22 student-athletes who had a concussion and another 21 who had not. Researchers found that the frontal lobes of those who had suffered a concussion was 10 to 20 percent smaller than those who had not had a concussion.
Fatality rate data released by CDC in report
Despite significant progress in lowering the fatality rates for car accidents in West Virginia and across the U.S., a recent report released by the Centers for Disease Control and Prevention, or CDC, establishes that much work needs to be done. The report, released on July 6, compares the U.S. fatality rates to those of 19 other wealthy countries, including the UK, Sweden, Japan and others.
Researchers examine traumatic brain injury in young people
Research published in the medical journal Pediatrics may have an impact on the treatment of brain injuries in West Virginia and across the United States. The researchers, from the University of Washington, estimate that between 1.1 million and 1.9 million children suffer a traumatic brain injury every year during recreation or while playing a sport. Most of the injuries go untreated.
Experimental drug may help people with TBI
Traumatic brain injury patients in West Virginia and across the country who struggle with memory loss may have new hope in a new drug called PDE4B. Researchers from Tetra Discovery in Boston and the University of Miami are responsible for the findings.
The pros and cons of settling a truck accident lawsuit
Truck accident lawsuits in West Virginia and around the country are often initiated by individuals who have suffered catastrophic injuries or by the surviving family members of deceased accident victims. While plaintiffs may be awarded considerable damages should they prevail in court, there is always an element of unpredictability with civil trials. The defendants in these cases may wish to settle matters quickly to avoid the publicity of a trial, and any offer they make is likely to include no fault or no admission of fault provision.
Owners of swimming pools must keep guests safe
Pool owners in West Virginia may invite friends and family to swim during the summer months. Before allowing other people to use their pool, owners should make sure that they are taking appropriate safety precautions. If someone is injured in a private pool, the pool owner could be held financially responsible under certain circumstances.
Autonomous tractor-trailer steering and braking system unveiled
Accidents involving semi-tractor trailers are a common occurrence on West Virginia highways, and many of these crashes happen when truck drivers find themselves in an emergency situation and do not have enough time to weigh their options and take evasive action. Computers are able to process information and make decisions much more quickly than the human brain, and truck parts makers the ZF Group and WABCO Vehicle Control Systems unveiled an autonomous crash avoidance system for tractor-trailers on June 28 that they hope will save lives by preventing rear-end collisions.


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Fleet Repair Auto Body Services
Courtesy Body Works is the ideal fleet repair provider for East Tennessee. We have extensive experience repairing and maintaining fleet vehicles. We offer a cost effective way to keep your fleet running and representing your business in the best way possible.
What Types of Fleet Vehicles Do We Service?
We repair fleet cars and small service vehicles. We do not repair box trucks or front loaders.
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Complete body, drivetrain, and suspension services including alignments and tire rotations.
Call us today to discuss fleet services for your business.
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Fleet Repair Clients


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The name on the chassis will be Hewlett-Packard, but many of the computers coming from HP in the future will likely bear Compaq Computer bloodlines--if the merger goes through.
March 8, 2002
Pension fund to vote against HP merger
CalPERS, the United States' largest pension fund, says it plans to vote against the proposed merger of Hewlett-Packard and Compaq Computer.
March 8, 2002
Fiorina: Execution key to success
In an exclusive interview with CNET News.com, HP's CEO says the company will hit the ground running should its mega-merger win investor support this month.
March 7, 2002
HP and hanging chads?
As in the last U.S. presidential election, the tallying of votes on the proposed merger could stretch well beyond Election Day.
March 6, 2002
S&P sees risks
Standard & Poor's cuts its ratings on HP's long-term and short-term debt, saying the merger's "execution risks" are significant.
March 7, 2002
HP shares gyrate
As if questions over the proposed merger aren't enough--the companies' shares are being thrown around by something called arbitrage.
March 6, 2002
FTC gives the go-ahead
The Federal Trade Commission has voted to approve HP's bid to acquire Compaq without conditions.
March 6, 2002
Merger gets big boost
The proposed merger receives a much-needed boost when an influential advisory firm recommends that shareholders approve the deal.
March 5, 2002
Salary issue delays advice
If HP and Compaq had openly discussed executive compensation, ISS, the advisory firm, would have been a bit quicker with its report.
March 5, 2002
Investors: Still not sure
ISS's recommendation in favor of the HP-Compaq merger draws a lukewarm response from investors and a cautious outlook from Wall Street.
March 5, 2002
Excerpts from the ISS report
The recommendation has long been considered crucial to the passage of the hotly contested $22 billion merger. Read portions of the report here.
March 5, 2002
previous coverage
HP-Compaq: Dumb and dumber
Tech industry veteran John Dickinson writes that the HP-Compaq food fight obscures the deeper challenges of the merger.
March 5, 2002
Customers weigh in
A survey shows that corporate customers are narrowly in favor of the merger of the companies, although many are undecided.
March 4, 2002
Weighing the proxy vote
Although some money managers are waiting for a key report to decide their vote, some smaller firms say their minds are made up.
March 4, 2002
special reports and news.context
Big iron: HP to buy Compaq
Analysts say HP faces a rocky road, as it works to survive while combining Compaq business units that are quite similar to its own.
September 5, 2001
Fiorina: All or nothing at all
vision series There is no turning back for Carly Fiorina, and she's in no mood to talk about "what-ifs."
January 17, 2002
Opening up about HP
newsmaker Amid an escalating war of words with Hewlett-Packard's board, Walter Hewlett tells the inside story behind his opposition.
February 14, 2002


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Medical Records and Confidentiality
A federal law known as HIPAA protects patient privacy and prohibits us from disclosing or discussing personal information or treatment regarding a patient without the patient's written authorization. Therefore, we must always speak with the patient regarding the care we provide, billing, medications, etc. unless there is a written authorization on file. This applies to children/adults/spouses/partners – no exceptions. Verbal authorizations are not acceptable.
Medical Records are property of the medical practice. Virginia State Law requires that requests for a copy of a patient medical record are made in writing. This request must be HIPAA compliant and must identify the patient including date of birth, current address, and signature. The request must also include where the records are to be sent with full name and complete address. Please allow 10 business days for medical records processing. A fee applies to the copying, mailing, and storing of medical records.


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I was watching the HBO broadcast of the HOF ceremony on my DVR last night, and noticed that the second time that the camera cuts to Herbie during Steve Perry's speech (the scene where Herbie is smiling), you can see a blurred version of Steve Smith in the background, sitting at the table! So, obviously, the grin that Herbie gives (at least in this scene) was not a reaction to Perry thanking him. Now I know that nothing on TV ever is exactly what it appears to be, and edits are made to help sell the sizzle…but I'm surprised that HBO let this edit slide, at least for the sake of continuity.
Check it out at 1:57.


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I struggle with all sorts of anxiety. The small kind, where you sit and try and remember what you forgot, and it nags at you, whether or not you actually forgot something. The mild kind, where your mind won't stop thinking about what you have to do tomorrow. Even the worst kind, when you feel like you can't breathe and that the world may cave in on you at anytime. But I am not a victim to it any longer; you no longer have to be, either.
Now, I want to start this post by stating plainly: not all of anxiety is sin. Therapist Peter Steinke says that anxiety is "a startle reaction" and it "protects you from potential risk or harm. Anxiety is a natural reaction designed for self-preservation. Our Creator has provided us with a strong urge for survival." (Steinke, Congregational Leadership in Anxious Times, 1) Our anxiety can be raised when we need to respond to danger, which is a good thing! Many good, Jesus loving Christians can be anxious and not sin.
But there are times when my anxiety goes too far, and it does become sin. There are a few reasons why mine turns to sin, and I share them with you to keep tabs on your sin. If we want to grow in holiness, we must learn how to turn our anxiety over to God. But, as the Spirit dwells in us, he gives us the means by which we can undercut anxiety's power through sanctification.
So, here are the things I need to look out for, and you can, too:
- My anxiety turns to sin when I trust in my power to provide over God's (Matthew 6:26-34). In the Sermon on the Mount, Jesus tells his listeners what they can do about anxiety. When they start to worry about what they are going to eat or wear, he tells them to change their mindset: consider animals. I frequently worry about paying for school. I'm not hard up for money, but if you want to make a donation, I can start a PayPal account. But, anxiety can still work its way into my mind and make a foothold, causing me to worry anyway. When I start to worry, I lose sight of God's provision. I trust only in my ability to make money, and think that will ease my concerns. In reality, the Lord does not say: consider the bi-weekly paycheck. He does not say, look for odd jobs. Rather, he asks us to consider the ways in which God provides for us instead. He simply says, look at the animals which don't gather: doesn't God still provide for them? If so, and to add a Pauline embellishment, won't he who provides for animals and gave up his Son not give us every good thing?
- My anxiety turns to sin when I don't bring it to God in prayer. Paul, in Philippians, tells us to not be anxious about anything, but in prayer and supplication, bring our requests to the Lord (Philippians 4:1-5). When our anxiety becomes too much to bear, two things can happen: we can look for simple answers, or we can seek only immediate solutions (Steinke, ibid., 9). In seeking immediate answers, we may try and alter the events on our own accord. Whether or not this solved our problem, we still sinned: we never prayed about it! There are times the Lord does not work the way we would want him to, yet, we are called to be obedient. But our anxiety turns our prayerful obedience into self-autonomous actions. It is not wrong to act to solve problems – we are not called to be passive observers! But it is wrong to not pray about something, whether or not we act, because we are told to pray without ceasing! Without prayer, we are admitting that we trust in our own power again and not resting solely on Christ's power.
- My anxiety turns to sin because it frequently makes me a proud person (I Peter 5:6-7). I hope you've caught the theme I suggested in the last two points: anxiety can cause us to trust in our power over God's. This is, quite simply: pride. We trust that we know what to do in every circumstance over the God whose voice and right hand created the world and the one who upholds the universe by his power. Peter tells us that the proper response to anxiety is to humble ourselves and bring the anxiety to God. I might even add a subpoint to point 3: anxiety causes me to miss out on God's good gifts for me. Notice that Peter lists two reasons to lift our anxieties to God. The first is that God cares for us. If we choose to take matters entirely into our own hands, we will miss out on letting God care for us. The God who voluntarily came to earth to die on a cross wants to serve us and take away our anxieties (Matthew 11:28). When we muddle through life without prayer, we refuse help from the God of comfort and the Prince of Peace. I know I don't want that! But here I am, anxiously trying to solve all of my own problems. Secondly, we will miss out on God's exaltation. It seems strange to think about looking forward to the benefits God gives us, right? Especially exaltation! But that's what we are promised in Romans: because we were called, we will be glorified. But we will miss that if we stubbornly remain in our pride. God has promised to bring down the low and bring down the high; here Peter tells us how we can humble ourselves, making sure we find ourselves being brought up in the resurrection. Don't miss this: the good gifts of God are available simply by praying about our anxiousness.
I don't mean to belabor the point, nor do I want to make anybody whose body is predisposed to anxiety feel worse about themselves than they already do. I hate knowing everything listed above and feeling powerless about stopping my anxiety. But thank God for Jesus Christ, who condemned sin in the flesh and has given me freedom from living under the yoke of anxiety. The reason I point out where anxiety becomes sin is that I don't want me or any of my brothers and sisters living under the power of canceled sin. Sin is destructive, but we are no longer slaves to it, but to righteousness. Hear this as a clarion call to step away from sinful anxiety and move toward the God who cares for us and will bring us up.


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When Bucs cornerback Eric Wright was not at practice Thursday, it was speculated because it was due to a setback in an Achilles injury he suffered during Sunday's game.
After all, Wright missed most of Sunday's game, and was limited Wednesday with the injury.
But coach Greg Schiano said Wright was excused for undisclosed "personal reasons." That begged the question whether Wright's absence was related to a report last month by Fox Sports' Jay Glazer that he's facing a four-game suspension for using Adderall - maybe he could be appealing it with the league?
When asked, Schiano only reiterated Wright was excused for personal reasons. "If he's healthy, he'll play on Sunday," Schiano said.
Of course, Wright's personal reasons could be just that - personal - whether it's related to his family or himself. But it certainly raised a few questions at One Buc Place.
Posted by Times Editor at 2:58:57 pm on November 15, 2012


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A Virus and a Vector, Evolving
A decade and a half ago a team of researchers came together in Portland to pursue the use of cytomegalovirus as a potential vector for vaccines. Its future will be determined by upcoming human clinical trials.
By Michael Dumiak
Oregon Health & Science University (OHSU) researchers in the state's pine-forested primate research center are preparing to do new things with something very old. Teams there are bolstering techniques and manufacturing practices as they ready an HIV vaccine candidate for safety studies in humans. The candidate employs cytomegalovirus (CMV) as the vaccine vector, a virus with a long history.
Probing further, OHSU researchers are manipulating CMV vectors in the hope of uncovering a tool for tailoring or "programming" different kinds of immune responses. Working with the large non-human primate (NHP) research program there, researchers hope to use CMV to create a "platform" approach to vaccine development, where a single vector is used for candidates against a variety of maladies. This work has gained the notice of high-flying venture capitalists. A US$150 million venture called Vir Biotechnologies launched earlier this year to support and grow the effort. Now it remains to be seen if the CMV candidate generating so much promising data in monkeys will deliver similar results in humans.
Something old, something new
The cytomegalovirus family tree stretches to the Triassic: the period of early amphibians and ferns. The virus has since undergone 200 million to 240 million years of Darwinian selection, making it very good at what it does. CMV infects 50 to 80 percent of Americans, most of whom show no symptoms. It is widespread in the developing world as well. Like other herpes viruses, CMV establishes lifelong latency in its host after infection.
Its persistent and widespread nature is part of what makes CMV an interesting vaccine vector. OHSU researchers are modifying the viral genome and hijacking it to carry HIV antigens, hoping CMV's persistence might also mean lifelong protection against HIV. The vector's other advantages include its low pathogenicity and efficient ability to reinfect, which should mean a CMV-based vaccine would be effective even if someone had already developed immunity to the virus through natural infection. Researchers also favor its large genome, which offers great potential for manipulation—it can express more than 200 proteins.
Louis Picker, associate director of OHSU's Vaccine and Gene Therapy Institute, is a familiar name in the HIV vaccine research field. Jay Nelson, founder and director of the Institute, and Klaus Frueh, an immunologist-turned-virologist who is a senior scientist there, are also integral parts of the operation. Each have their own labs in Portland. All came to the Pacific Northwest by following CMV as a beacon. Nelson was already established as a CMV expert by 1992, coming to OHSU as a molecular virologist interested in the pathogenesis of the virus. The operation then really began to develop in the late 90's and early aughts.
Frueh had been working first at The Scripps Research Institute in La Jolla and then for Johnson & Johnson (J&J), where he was director of an antiviral pharmaceutical research program. He was, at first, interested in studying how viruses evade detection from CD8+ T cells. Peter Ghazal, a molecular geneticist and former trainee of Jay Nelson's, was working then with a viral protein from herpes simplex. Ghazal was the one who brought Frueh's attention to a growing body of work about CMV. Frueh then began focusing on how CMV counteracts CD8+ T cells. Nelson recruited him to Portland in 2000.
By then Picker was already there, coming from Dallas where in 1999 he'd been working as a pathologist monitoring immune responses in specimens from AIDS patients at the University of Texas Southwestern Medical Center. Picker first directly encountered HIV as a resident at Boston's Beth Israel in early 1983, where he was performing postmortems on patients dying of a mysterious virus prompting unusual, awful symptoms and devastating immune system collapse. What would come to be called AIDS continued to affect Picker personally. As the southern California native continued in his medical studies at the University of California, San Francisco, he lost classmates and acquaintances. He published his first clinical pathologic paper on HIV in 1985 and studied human T cell biology for the next decade. He started working on HIV from that point on.
While in Dallas, Picker became drawn to CMV and its potential in vaccine development. It stood out to him because the virus is largely benign and because it induces very strong lifelong immune responses. In long-term, healthy carriers of CMV, upwards of 10 percent of T cells that distinguish self from non-self are devoted specifically to CMV proteins, says Peter Barry, director of the Center for Comparative Medicine at the University of California, Davis. Barry's lab also works with CMV and collaborates with the OHSU researchers.
Picker wanted to act against HIV, and Jay Nelson, CMV expert, already headed the Vaccine Institute. It was a perfect match. Picker, Frueh, and Nelson began collaborating on antigen design. Frueh and Nelson grew experimental batches of CMV vector candidates, while Picker designed and conducted trials with the center's rhesus macaque population. The continuing experiments built up a collection of data illustrating how CMV induces immune responses in monkeys and how these immune responses affect SIV.
In 2009 Picker and colleagues showed that a rhesus cytomegalovirus (rhCMV) vector expressing the simian immunodeficiency virus (SIV) proteins Gag, Rev/Nef/Tat, and Env primed and maintained effective SIV-specific immune responses in 12 vaccinated rhesus macaques challenged with the highly pathenogenic SIVmac239 strain (Nat. Med. 15, 293, 2009). While all of the control group of 16 animals became progressively infected with SIV after repeated low-dose challenges, four of the vaccinated macaques never showed sustained SIV infection. It turned out they completely controlled it.
This suggested that the CMV-based vaccine immediately and completely controlled viral infection, with experiments later showing that this control is followed by clearance of the infection. Results from a study published the next year were the first to show that downregulation of major histocompatibility complex (MHC)-1, a set of cell surface proteins that tell an immune cell about foreign molecules, enabled CMV superinfection. This suggested that widespread pre-existing immunity to CMV would not hamper its use as a vector (Science 328, 102, 2010 and see CMV Superinfection No Longer Shrouded in Mystery, IAVI Report, Vol. 14, Issue 2, p. 17).
In 2011, researchers showed that the rhCMV vector could produce a 'functional cure' of SIV-infected macaques, likely due to a memory T-cell response (Nature 473, 523, 2011). A follow-up study from Picker's group showed the experimental CMV vaccine also led to undetectable SIV levels in about 50 percent of macaques challenged vaginally and intravenously, as well as intrarectally (Nature 502, 100, 2013). This indicated that the vaccine-induced immune responses can control viral load in the blood as well as the lymphoid tissues where SIV and HIV establish infection, Picker says. Most importantly the study showed clearance of the SIV infection in protected monkeys over time. This was a startling and highly publicized finding, one still generating new experiments. At the most recent Conference on Retroviruses and Opportunistic Infections (CROI) in Seattle, Picker outlined how his group's current efforts to determine whether the SIV reservoir is progressively eliminated by vaccine-induced SIV-specific immune responses, or whether these immune responses initially limit the formation of the viral reservoir to such an extent that it dwindles to nothing over time (see Rallying CROI, IAVI Report, Vol. 21, Issue 1, p.13). Experiments so far indicate that the rhCMV immunization is limiting the formation of the viral reservoir, a finding that could have a bearing on research into an eventual HIV cure.
Even now though Picker cautions that a cure strategy is on a much slower track than prophylactic CMV-based vaccines. "An HIV cure is sort of a separate issue. We're asking whether it will work for that. It's a very different kind of application than a prophylactic vaccine, even though the virus is the same. It's just like Hepatitis B. We have a prophylactic vaccine for Hepatitis B. We all take it. It works very well. But we don't have a vaccine that gets rid of Hepatitis B in people that are chronically infected. Therapeutic and prophylactic are two very different things," he says. "We're way more advanced in the prophylactic vaccine."
|The birth of a vector
Cytomegalovirus (CMV) may have a pedigree stretching back beyond the pterodactyl, but the roots for using CMV as a vector lay in a technique developed in Germany in the 1990s by Ulrich Koszinowski and Martin Messerle.
Messerle and Koszinowski developed a strategy for the cloning and mutagenesis (or recoding of the genetic information of an organism) of an infectious herpesvirus genome. After modification, it is maintained as a bacterial artificial chromosome, which is a DNA construct that can replicate when inserted into bacteria. Messerle and Koszinowski then showed that they could take a mouse CMV genome and maintain it as a 230 base-pair bacterial artificial chromosome when inserted into E. coli (Proc. Natl. Acad. Sci. 94, 14759, 1997). Doing so allowed scientists to modify the genome—mutate, insert, or delete pieces of its genetic code—more easily than before. —MD
Programming an immune response
All the key data on rhCMV as a vaccine vector so far come from Picker's OHSU team, as they are the only ones to publish on it so far, Barry says. OHSU was uniquely positioned to do this work. Researchers there can draw on the resources of the primate center, as well as the scientists with immunology and virology expertise in CMV.
This expertise was assembled step by step, but the run of successful experiments started with a stroke of luck, Picker says. The rhCMV vector that the Oregon researchers began experimenting with has a genetic configuration unlike any other CMV vector. It contains specific gene deletions in discontiguous places that turn out to be required for inducing the specific immune responses required for protection. "If we'd started out with a different CMV variant, we might not have seen this," Picker says. He has five papers lined up on his desk detailing this work, but the ongoing effort to translate the monkey work into human trials is taking precedence these days.
"When we started vaccinating monkeys and ultimately challenging them, we saw a CD8+ T-cell response to SIV," Picker explains. "We had no inkling that there was going to be anything unusual. We saw this efficacy, and to try and figure out correlates for this efficacy we started doing detailed analysis of the immune response." The CD8+ T-cell response to SIV is well characterized following vaccination and natural infection. There are canonical epitopes in this response: a monkey that is said to be Mamu-A01+, which is an analog for the human coding complex for MHC proteins, will typically respond to a certain peptide (Immunogenetics 38, 141, 1993; Virology 77, 9029, 2003).
But when the group vaccinated with a CMV vector, though, they didn't see this kind of response to the canonical epitopes (Science 340, 6135, 2013). "That was an important clue telling us that we should look at the epitopes and what was going on there, because maybe that was important," Picker recalls. The Oregon researchers suspected the control they observed in the vaccinated macaques came from a more promiscuous immune response involving multiple epitopes.
So Frueh and Nelson continued to construct vectors, and Picker tested them. The results created an understanding of the gene coding in CMV that elicits both unconventional and conventional responses. Picker has said publicly in meetings that the unconventional responses are what seem to be required for efficacy. Both Frueh and Picker were recently in the Netherlands at a CMV workshop discussing ongoing research. It appears they are on the cusp of characterizing which viral genes are required to get specific vaccine-induced immune responses. This boosts CMV's prospects not just for HIV but as a potential vaccine platform.
The group is now working to show that genetically altering CMV can actually "program" highly diverse CD8+ T-cell responses that differ in their epitope targeting. "The issue is understanding how that works and understanding not only how those responses are generated by CMV, but also what they are good for," Picker explains. "At this point, we know that they're good for a prophylactic SIV vaccine and, presumably, an HIV vaccine. And in data that we're going to publish hopefully soon, it seems to work for tuberculosis as well." The unconventional responses elicited by their CMV vectors are dependent on the deletion of 157.5/.4 genes (Science 351, 714, 2016), as well as other genes about which the group has not yet published.
Ubiquitous but unique
While the momentum in HIV vaccine research over the last decade has been much on the side of designing an antigen that would prompt or "coach" the body to start producing antibodies against the disease, specifically antibodies that neutralize a broad spectrum of HIV strains, a CMV-based vaccine would work a little differently. It is not intended to induce antibodies, and in its current configuration, it doesn't. It would instead rely on the body's ability to mount a strong T-cell response to CMV. The persistence of the response allows the T cells that it elicits to avoid going into a resting state, so they remain ready to manifest antiviral activity. Picker describes it as the 'early intercept' hypothesis. "If you meet it at the beachhead, so to speak, it never has the chance to use its programmed host evasion mechanisms, and therefore it is vulnerable."
But some of CMV's advantages could also prove to be concerns: a persistent vector that causes harm would be problematic. While CMV is widespread and largely benign, it can be dangerous in pregnant women and associated with accelerated senescence of the immune system (Virus Res. 157, 175-9, 2011). CMV is also linked by some researchers to poor outcomes in elderly people. These effects seem linked to the persistent immune stimulus caused by the virus's enduring potency.
The Oregon researchers are at pains to say safety is the priority. "We're all very aware of that literature. The way to prevent that is basically to limit the ability of CMV to reactivate and disseminate, and that's why our clinical vectors will be attenuated. All of this literature really depends on the virus being able to reactivate in old people and disseminate, and our vectors won't be able to do that," Frueh says. "The literature on involvement of CMV in immunosenescence is highly controversial. We also need to recognize that basically CMV is part of our immune system. It has been for a long time."
Peter Hunt, who researches the inflammatory consequences of HIV infection from his post as associate professor of medicine at the University of California, San Francisco, also thinks the immunosenescence problem is overstated. "While the dogma that 'CMV accelerates aging' has been in the aging literature for some time, this has been widely misinterpreted and paints too broad a brush," he says. "I have very few concerns about Louis's fibroblast-adapted vector," Hunt adds, referring to Picker and the OHSU vaccine candidate. "His data are some of the most exciting preventative vaccine data to emerge from non-human primate models of HIV infection."
Which may be why the CMV program has drawn the attention of venture capitalists. At the start of this year, a company calling itself Vir Biotechnology made its debut in San Francisco with the backing of a top-flight venture capital firm run by biotechnology impresario Robert Nelsen, as well as funding from the Bill & Melinda Gates Foundation. Set to run the firm is George Scangos, the former chief executive of Biogen, a high-flying Boston biotech founded by Nobel Prize winners. Vir has grand plans. At the heart of the company is CMV.
By 2010, Frueh says, about the time the impressive data was emerging from their CMV vector experiments, the group—Nelson, Picker, Ulrich Koszinowski, and Frueh—began to talk about starting a company to spin off their CMV vector. The research effort was growing larger and it became clear that successful results might lead to a marketable product. In the fall of that year they launched a spinoff called TomegaVax. It fell to Frueh to guide it. He's the one who'd previously worked in industry. "I did have that, though I have no experience in building a startup company. Neither did any of the other founders. We were like the blind leading the blind in some ways," Frueh says. What he had done as part of his job at J&J, though, was to evaluate the stream of biotech interests that approached the company in search of an industry partner: a deal. The experience was quite valuable down the road as Frueh began striding the circuit with TomegaVax, looking for backers.
There are compelling reasons to start a spinoff. One is that as an academic the university owns what you do, for better or worse. In the US companies are also eligible for small business grants. In 2014 TomegaVax landed a $225,000 federal small business research and development grant to pursue a CMV-based vaccine against human papillomavirus, which is a prerequisite infection for the development of cervical cancer.
About this time the Gates Foundation and the US National Institutes of Health were also paying close attention to what was happening at the OHSU primate center. By 2014 Picker's lab received $25 million from the Gates Foundation; last year the National Institutes of Health provided $14 million.
Once OHSU's results began suggesting that by modifying cytomegaloviral determinants that control unconventional T-cell priming it is possible to uniquely tailor the CD8+ T-cell response for each individual disease target, it was clear they were outgrowing TomegaVax's capabilities. "It's not something that we anticipated when we started, that we would be able to do this. We're rewriting textbook immunology," Frueh says. "We were actually asked by the Gates Foundation to find a corporate partner." This is a measure of success, but also a challenge. TomegaVax had set up shop in a Portland biotech hub in a warehouse district along the Willamette River. "The problem there was that everyone loved the technology. It was clear that this was something new. But we didn't have experienced management," Frueh says.
Last September, though, Bob Nelsen came calling. Nelsen, a co-founder and managing director at the venture capital firm ARCH Venture Partners, is based in Seattle and is known at Forbes as 'Biotech's Top Venture Capitalist.' Nelsen had a vision for CMV. "It's a much bigger vision than we had for the company," Frueh says. "He was really saying, 'Let's build a big startup right out of the gate that has the capability of trying out different platforms and has enough money to do multiple clinical trials.'"
ARCH Venture brought $150 million to the launch of Vir Biotechnologies, with the Bill & Melinda Gates Foundation also contributing as a lead investor. Other funding, according to Vir's January launch announcement, will come from sovereign wealth funds, public mutual funds, philanthropists, and family offices. "Vir seeks to take a new approach, using breakthroughs in immune programming to manipulate pathogen-host interactions. The company will take a multi-program, multi-platform approach to applying these breakthroughs, guided by rigorous science and driven by medical need," the company says on its website. It is adopting a broad technological portfolio, including everything about CMV that was obtained with TomegaVax. Though it's still early days, the roles at Vir Biotechnology are pretty clear: Scangos is chief executive, Picker is scientific advisor, and Frueh is a director.
Inflection points
With the launch of Vir Biotechnologies the Oregon team has reached an inflection point: having secured resources, it is now all about translating the promising data they've collected in monkeys to humans.
In a cramped office off a hospital hallway at OHSU's sprawling teaching hospital in Portland, Marcel Curlin, a young, bushy-haired researcher and a new member of the team with a background in HIV clinical trial research in Bangkok, is leading the effort there to screen potential volunteers for the vector's Phase I safety trials. Curlin expects to screen 400 Portland-area residents to make sure they already carry CMV (and that their partners do as well) and that they are not pregnant or carry other risk factors. The goal is to enroll 75 volunteers for a Phase I trial. The start date, though, is a little fuzzy. There have been challenges along the way involving the CMV vector itself.
One is achieving the right level of attenuation to limit the ability of CMV to reactivate and disseminate, in other words to ensure its safety. The team developed a "safety valve" for the vector to accomplish this by deleting a gene that is essential for virus dissemination. Deleting this gene eliminates safety concerns, but the key is to balance safety with efficacy—an over-attenuated vector may render it less able to induce the types of immune responses that were protective in animal studies.
Another delay is because of the findings on immune response programming. Programming could wind up as a stellar advantage for building a vaccine platform, the very thing that interests Vir in CMV. The researchers don't want to use vectors in humans that have different modifications compared to the original monkey work, so clinical vectors had to be re-designed according to the most recent results. Researchers found another essential change last year that had to be added to the clinical vector.
All told, these efforts have caused the timeline for human trials to slip from an expected start this summer. Picker now says the earliest that trials will get underway is the end of 2018 and that will probably move into early 2019.
"We're rushing to finish up this characterization and to get the correct human vectors. We only figured out in the last year how to make them and they have to get to manufacturing standard," Picker says. "We're running hard to try and do that. Obviously, the monkey model is great, but," he trails off. If CMV's promise doesn't translate to humans, it would be a huge setback. If it works similarly, ARCH estimates it may deliver $500 million to the overall CMV project.
Frueh has emerged as the point person in solving some of the manufacturing issues involved in making a vaccine a real possibility. "I'm actually not a trained virologist," he says. "I'm now the virologist in this program." Yet Frueh is relaxed in his corner office, looking over the primate center's central services complex, a midcentury mod-style building. The primate houses are just beyond, where hundreds of monkeys are either leaping around in cages or in a big open oval, socializing.
Although Picker's primary interest is the basic science, he is finding the translation of the CMV work to humans an interesting (and necessary) challenge. "The reason I haven't burnt out yet is that this isn't just development of a vaccine where you completely understand how it works and the energy is in making it manufacturable," he says. "To do this translation you have to understand the basic science. It's interesting and different and weird immunology. It creates problems—you stretch your colleagues' credulity. But when you come down with solid findings, it's fun."
Michael Dumiak reports on global science, public health and technology and is based in Berlin.


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JAPAN: Mitsubishi Corp. takes Isuzu stake to strengthen Thai partnership
Mitsubishi Corp. is reported to be investing in truck maker Isuzu Motors in an effort to strengthen a Thailand-based partnership between the two companies.
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The only constant is change. That is to say, things are constantly changing. Just when you think you've got a full grasp on the internet and all the possibilities it brings, along comes a paradigm shift that moves the game from the home or office. Now, instead of using e-commerce through the internet, we can use m-commerce through the entire global communication network.
E-commerce Versus M-commerce
What is the difference between e-commerce and m-commerce?
E-commerce (electronic commerce) is generally considered to be any type of transaction that takes place using the internet. Many popular transactions are banking, paying bills, and shopping. These activities take place using desktop computers and laptop computers that are located in the home or office.
M-commerce (mobile commerce) is also any type of e-commerce transaction, only access to the internet is not required because these activities now take place using smartphones and tablets as telecommunication devices. And, because these activities are mobile, they can take place just about anywhere: home, office, riding in a car, walking on the beach, etc.
Mobile Optimized Websites
As the e-commerce business model continues to evolve into m-commerce helping to create the Internet of Things (IoT), optimizing the user experience with an easy-to-use mobile interface becomes key to the effort of ensuring that potential customers and users return for more.
Mobile optimization ensures that visitors who access your site from their smartphone or tablet enjoy an experience optimized for their specific device. This means that your site reformats navigation buttons, content, and images so they display correctly, no matter what device is used to view your site.
Besides being easy to read and navigate, the website must load quickly. A data hungry page that takes too much time to load is not going to attract a loyal, mobile user base.
Adoption Rate
What is driving the adoption rate of m-commerce?
Practically all top companies now have mobile apps for their customers that attract more users, make doing business much easier, and provide a better customer experience, all while saving the company money through better processes.
This includes:
- Taking mobile payments for goods and services
- Providing mobile banking services that facilitate deposits and transfers
- Allowing for filing insurance claims
A Walk in the Park
On a recent walk through a local park, a friend pointed out that almost without exception, our fellow park visitors had their heads buried in a smartphone screen. Whether sitting on a park bench or slowly making their way down the walking path, everyone was doing something with their cell phone. It did not matter if the person was alone or in a group. There seemed to be little to no talking or any kind of communication between them. All were engrossed with their personal technology.
Of course, there is always the exception. There was one group walking by that was not actively using their phones, but were simply carry them in hand – possibly for future reference?


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Danish IT Society AccreditedDANSK IT becomes newest APMG accredited exam institute for ITIL qualifications.
ITSM Watch Staff
The APM Group has announced a new partnership with DANSK IT (The Danish IT Society). DANSK IT has signed a contract to become an APMG accredited examination institute, offering ITIL exams. DANSK IT is an independent, highly regarded and well established body within
Founded in 1958, DANSK IT is among the first IT interest groups in the world. CIOs, IT-architects, IT-engineers, IT-lawyers and IT-consultants are among DANSK IT's 6,000 plus members, making it the largest association for IT professionals in Denmark.
"Since 2003 DANSK IT has worked with the British Computer Society to promote the entire ISEB portfolio into the Danish market, among these qualifications ITIL (Version 2). With APMG becoming the OGC's Official Accreditor for ITIL in 2006, DANSK IT is happy to have reached an Examination Institute Agreement with APMG, enabling us to continue the delivery of our ITIL services into the market in
The purpose of DANSK IT is to promote the knowledge and utilization of IT to the benefit of both IT-users and the Danish society. These intentions are reflected within the area of certification, where DANSK IT has worked as a certifying body at professional and user-level for more than a decade. Since 1996 DANSK IT has accredited roughly 400 test centres/ATOs and administered the testing and certification of roughly 300,000 candidates within areas ranging from basis IT-level, e.g., ICDL to IT-professional levels such as Software Testing or IT Service Management.


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A Poppy's Place is an assisted living home located
in the Denver / Centennial, Colorado area.
We provide a full spectrum of assisted care services. Personalized attention is given when assisting our residents with bathing, dressing, meals, medication monitoring, ambulation and other unique needs.
Our services also include:
In addition to experienced care givers, we have visiting doctors,
nurses and therapists.
The goal of A Poppy's Place is to create an environment where our residents, permanent or transitional, can be as comfortable and active as possible while best catering to each person's individual needs.
We provide many on and off-site activities and recreational opportunities including:
Thank you for taking the time to look through our website and see the possibilities.
Click here for our Resource Library. It provides a wealth of helpful information regarding the difficult process of moving your parent or loved ones into an
assisted living environment.
My grandmother resided at Poppy's Place for over five years. She was treated like a family member from the day she moved in. Though severely disabled due to a stroke, everything was done to help her feel "enabled" to the extent possible.
~Lisa B.
Our mother was always treated with respect and kindness during her stay at Poppy's Place. The care provided was loving and personal. The owner developed a special relationship with both Mom and the family which reassured us that Mom was receiving the best care possible in the last years of her life.
~Caroline S.
Dad was a vigorous, well-educated gentleman. He was given a position of honor at social gatherings at Poppy's Place and often did the blessings at meals on behalf of the residents and staff.
~ Christine J.
The meals are primarily home-cooked and delicious. Mother's appetite has improved since she moved in and her weight
has now stabilized.
~Jennifer N.
At Poppy's Placed assisted I lost nearly 112 pounds. My physical status and over all health improved to the point that I was able to move to a more independent living environment after three years.
~Patricia P.


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Providing In- Home ABA Therapy for Children
ABA Therapy Works is an affiliate of speech Therapy Works. We are servicing children on the Ontario Autism Program.
ABA Therapy with ABA Therapy Works Toronto
Behaviour therapy or ABA therapy uses principles of behaviour analysis to teach new skills including language. Behaviour analysis focuses on how learning takes place. When behaviour is followed by a positive reinforcement or a reward, the behaviour is more likely to happen again. Through years of research behaviour analysis has developed techniques for increasing useful behaviours and reduce behaviours that are harmful to child's learning and independence.
ABA behaviour uses techniques from behaviour analysis to bring positive changes in a child's behaviour. ABA therapy helps children with autism and other developmental disorders to acquire and master new skills. ABA therapy can target new skills such as pointing or advanced skills such as doing math homework independently.
ABA Therapy for Children with Autism
ABA therapy is widely recognized as effective treatment for children with autism. It is funded by the Ontario Autism Program (OAP) through the Ministry of Children and Youth Services (Scroll down for more information). ABA therapy has proven to increase positive behaviours in children with autism and increase independence in all aspects including language use, communication and social interaction. ABA programs allow children with autism to learn, practice and master a variety of skills in both structured and unstructured settings.
ABA therapy uses positive reinforcement (reward). When behaviour is followed by a reward, it is more likely to be repeated. In ABA therapy we determine what the child is motivated by (reward) and use it to increase an existing positive behaviour or create a positive behaviour. ABA therapy increases useful behaviours e.g. sharing toys and decreases negative behaviours that interfere with learning e.g. biting, screaming, hitting.
ABA therapy can be comprehensive and target a full range of skills. It can target self care (dressing, toileting), sociability (initiating eye contact, responding to name, taking turns), readiness for school (engaging in structured activities, tracing, holding a pen, alphabets) and communication (using words, requesting, answering questions appropriately).
When to start ABA therapy and how often?
ABA Therapy works believes in Early Intervention. Research shows that earlier the start, faster the learning happens. Learning happens faster when the child is younger. Early intervention is designed to begin before the age of 4. ABA therapy can be less intensive (4-15 hours a week) or intensive (25 hours or more). Research has shown that children that receive intensive ABA therapy make larger improvements in more skill areas.
Why work with ABA Therapy Works?
We customize programs and goals to each child's skills, needs and interests. We disapprove of the 'one size fits all'approach. ABA therapy is customized to each child's needs, interest and family situation. ABA program for one child will look different than a program for another child.
A Board Certified Behaviour Analyst (BCBA) completes the initial consultation or assessment using parent reports and formal tools. Based on the assessment, individualized programs and data collection methods are developed. Each program breaks down desired skill into steps to be taught from simplest to more complex. The BCBA also oversees the intervention and makes necessary changes as progress is achieved by the child. Goals and programs target a broad range of skills including language, communication, self care, safety, motor skills, toileting, academic skills and attention.
Behaviour Therapy Works team consists of child friendly BCBAs and Instructor therapists. We are passionate about working with children with varied skills. We use a family oriented method to develop programs and implement programs. We provide ABA therapy at our clinic and at the convenience of your home in Toronto and the GTA.
Funding for ABA therapy
All children diagnosed with Autism under the age of 18 are eligible for funding through the Ontario Autism Program (OAP). Families can use the Direct Funding Option (DFO) to receive flexible, quality and convenient services by ABA Therapy Works at your home. We are able to develop an OAP Behaviour Plan to ensure funding from the Ontario Autism Program. ***We will be updating this section with additional information soon*****
Visit The Ontario Autism Program (OAP) website to apply for funding
Contact your Regional OAP office
Find additional Information on the Direct Funding Option (DFO)
Frequently Asked Questions related to OAP


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The term "liver disease" applies to many diseases and disorders that cause the liver to function improperly or stop functioning. Abdominal pain, yellowing of the skin or eyes (jaundice), or abnormal results of liver function tests suggest you have liver disease.
See also:
Ergasa NV. Approach to the patient with liver disease. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier;2007:chap 149.
Updated by: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
MedlinePlus Topics
Read More
A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission (www.urac.org). URAC's accreditation program is an independent audit to verify that A.D.A.M. follows rigorous standards of quality and accountability. A.D.A.M. is among the first to achieve this important distinction for online health information and services. Learn more about A.D.A.M.'s editorial policy, editorial process and privacy policy. A.D.A.M. is also a founding member of Hi-Ethics and subscribes to the principles of the Health on the Net Foundation (www.hon.ch).
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. Copyright 1997-2012, A.D.A.M., Inc. Duplication for commercial use must be authorized in writing by ADAM Health Solutions.


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During these uncertain times, how can we help?
See below to participate in our Impact Sector survey, access our COVID-19 Resource Hub, and explore our growing directory of COVID-19-specific and virtual volunteering opportunities.
Our Mission: To inspire, empower and promote community engagement in underserved communities through the medium of art, advocacy, outreach and programming.
We Are:
A vision driven organization that believes no one wants to exist in isolation. That within the core of each of us, lives a humanatarian desire to connect, give and positively impact the world around us, starting within our very own community.
Our purpose is to ignite that desire, through the medium of art, engagement and inspiration.
I Am We is a non-profit 501(c)(3) arts organization, in partnership with Goodcity.
Connecting Community. Inspiring Excellence.
I Am We accepts donations. Donate Now.
Do you work for this organization?
Request administrator status and update its information!


text: Thank you to everyone who has generously donated quarters, laundry soap and snacks. We are currently low on quarters. If there are any activity books, crayons, sidewalk chalk or small game activities you can think to donate for younger children to use while they are sitting there for hours in a small space. All donations can be dropped off at Huber-Moore Funeral Home or dropped the night of the event at the Laundromat from 5:30-9pm.


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April 28, 2014
Ontario Centres of Excellence (OCE) will deliver four new programs on behalf of the Ontario government that mark a significant investment in young entrepreneurs and job creation.
"This is a significant step forward in the evolution of Ontario's entrepreneurship and innovation ecosystem," said OCE president and CEO Dr. Tom Corr at the program launch in London on April 24. "Together, these programs represent an investment in Ontario's students and young entrepreneurs that will equip them with the skills, experience and support they need to succeed."
Part of Ontario's $295-million Youth Jobs Strategy, these programs will provide young entrepreneurs with business skills, capital to start and grow a small business and the opportunity to gain experience and expertise through R&D internships. Five programs in total were part of the announcement.
"Helping young entrepreneurs and those seeking rewarding careers in R&D is another example of Ontario's Youth Jobs Strategy at work," said Reza Moridi, Ontario's Minister of Research and Innovation. "These programs will help harness their ideas, their vision and enthusiasm and turn them into jobs for today and for tomorrow. It is their ideas, courage and drive that will build Ontario's future."
The programs OCE will deliver are:
MaRS Discovery District is delivering the $7-million Youth Business Acceleration Program to equip young entrepreneurs with skills needed to start and grow successful technology businesses.
The Youth Jobs Strategy is part of the government's economic plan that is creating jobs for today and tomorrow. The comprehensive plan and its six priorities focus on Ontario's greatest strengths -- its people and strategic partnerships.
To date, more than 10,000 jobs have been created under the Youth Jobs Strategy.


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Current Account Patterns and National Real Estate Markets
NBER Working Paper No. 13921
---- Acknowledgments ----
Financial support from the College of Humanities, Arts, and Social Sciences at NTU is gratefully acknowledged. We thank Jess Moyer (Investment Property Databank), Ong Qiyan, Francis Ng, and Jiang Zhimin for their helps with real estate data. We would like to thank Marty Feldstein for very useful comments. Any errors are ours. The views expressed herein are those of the author(s) and do not necessarily reflect the views of the National Bureau of Economic Research.
Contact Us


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With the javascript community there are a lot of standards out there and some teams have none, others say they do but they make little sense to people. And when you ask why? you get multiple answers which is a sure sign you have unclear standards.
So to start out with I'm going to pull in an except from one of my favorite standards guide, written by one of mine and your favorite companies, Google!
This is the section on naming:
use functionNamesLikeThis, variableNamesLikeThis, ClassNamesLikeThis, EnumNamesLikeThis, methodNamesLikeThis, CONSTANT_VALUES_LIKE_THIS, foo.namespaceNamesLikeThis.bar, and filenameslikethis.js.The filenames is the one I see the most common errors on, and people will say it will never happen but I've worked in mixed teams before, and by mixed I mean windows, mac, and ubuntu, and we had issues.
Filenames should be all lowercase in order to avoid confusion on case-sensitive platforms.
Filenames should end in .js, and should contain no punctuation except for - or _ (prefer - to _).
The last part I myself have sort of broken but I'm not sure it really is a break. For unit tests I will do filename.spec.js as the format I feel it makes it easier to spot the test files.
Anyhow more later. Enjoy!


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Other than as described in this Policy, we will not give any information about you to others without your express permission.
We may also use your information to present a co-branded offer with our partners or affiliates. If we collect information from you in connection with a co-branded offer, it will be clear at the point of collection who is collecting the information and whose privacy statement applies.
This Site has security measures in place to protect against the loss, misuse or alteration of the information under our control.
We use emails to communicate with you, to confirm your placed orders, and to send information that you have requested. We also provide email links, to allow you to contact us directly. We strive to promptly reply to your messages.
The information you send to us may be stored and used to improve this Site and our products, or it may be reviewed and discarded.
We may at times provide information about you to third parties to provide various services on our behalf, such as processing credit card payments, serving advertisements, conducting contests or surveys, performing analysis of our products or customer demographics, shipping of goods or services, and customer relationship management. We will only share information about you that is necessary for the third party to provide the requested service. These companies are prohibited from retaining, sharing, storing or using your personally identifiable information for any secondary purposes.
In order to provide certain services to you, we may on occasion supplement the personal information you submit to us with information from third party sources (e.g., information from our strategic partners, service providers, or the United States Postal Service). We do this to enhance our ability to serve you, to tailor our products and services to you, and to offer you opportunities to purchase products or services that we believe may be of interest to you.
From time-to-time, we may provide you with the opportunity to participate in contests or surveys. If you choose to participate, we may request certain personally identifiable information from you. Participation in these contests or surveys is completely voluntary and you therefore have a choice whether or not to disclose the requested information. The requested information typically includes contact information (such as name and address), and demographic information (such as zip code and age level – note that you must be 18 or above to enter). We use this information to notify contest winners and award prizes, to monitor site traffic, and to personalize our Site. We may use a third party service provider to conduct these surveys or contests. When we do, that company will be prohibited from using our users' personally identifiable information for any other purpose. We will not share the personally identifiable information you provide through a contest or survey with other third parties unless we give you prior notice and choice.
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Tick off three of the most popular Greek Islands in one go! Enjoy the natural beauty, laid back lifestyle and endless partying that you will experience on your trip your 7-day tour from Mykonos to Ios. Your accommodation, breakfast and ferries are arranged for you so you can completely relax and unwind.
The perfect place for sea, sun & party type of holiday! Don't forget to visit the tomb of the famous Greek poet, Homer, before you get lost in the night.
Greece's most famous with blue flag beaches, whitewashed streets and vibrant nightlife. You won't want to leave the 'The Island of the Winds'!
The most beautiful sunset in the world… This volcanic island has unique scenery with its multi-colored cliffs and beaches. Pour yourself a glass of wine and enjoy.
2 & 3 & 4 star hotels
6 breakfasts
Economy class ferry
Transfers from the island ports to the hotels and from hotels to the island ports
Services of experienced Travel Talk tour leader
This hotel is located in Tourlos area, very close to central Mykonos, offers an outdoor swimming pool and wi-fi all around the hotel.
New Haroula hotel is located in the centre of Fira, the capital of Santorini. The hotel offers an outdoor pool and free access to Wi-Fi. All air-conditioned rooms are equipped with a fridge, satellite TV and a balcony overlooking the pool or the bougainvillea garden.
Hermes Hotel is centrally located, only 700 meters away from the town, offers an outdoor swimming pool, and it's also 7 minute walk to the beach.
This hotel is a famous one among the Ios hotels with it's swimming pool and pool bar, it allows you to walk to the town and beach only in a few minutes.
5 minute away from the port of Ios, this modern hotel features an outside swimming pool and air-conditioned rooms with satellite TV.
At Travel Talk we do not only provide excellent value for premium adventures, but also strive to exceed expectations in every aspect of our trips, which is reflected in an enviable 98.9% customer satisfaction. We believe that our affordable tours, quality accommodation, transportation and sightseeing tours combined with likeminded people, passionate tour leaders and the overall atmosphere of a Travel Talk tour have made these results. However, we are never ones to rest on our laurels, and we continually try to improve on this year after year; and what do we get out of this? The satisfaction of our travellers!
If you are one of our previous travellers and wish to share your experience with others please fill in the form below. Thanks!
Open until midnight
+44 20 8099 9596
Monday - Friday:
Saturday: 10:00 AM - 5:00 PM
Sunday: Closed
W. Europe


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the inadvertent brush of a tree branch against power transmission lines set off a cascade of failures that within hours grew into the largest blackout in US history, affecting more than 50 million residents of the Northeast and Canada. These flying buzz saws are here to ensure that never happens again.
Known as aerial side-trimmers, these devices are essentially a string of rotating buzzsaws affixed to the bottom of a helicopter. The pilot navigates his aircraft into position between the power lines and overgrowth, engages the saws, and slowly makes his way down the line, clearing three to six miles of brush every day (that's on both sides of the power lines, natch).


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The Specialist Buyers Guide for the Construction Industry
Found Under:Acoustic Wall Panels Cladding Supplies Cladding Systems External Wall Ins... External Walling ... Insulation Materials Plasterboard and ... Plasterboard and ... Modular & Mobile ... Modular Buildings Oak Framed Houses Off Site Construc... Prefabricated Bui... Timber Frame Systems Bi Fold Doors External Doors Fire Resistant Doors Front Doors Interior Doors Roller Shutter Doors Joists & Flooring... Architectural & D... Architectural Design Sustainability Co... Green Roof Constr... Green Roof Systems Lightweight Roof ... Plastic Roof Tiles Roof Slate Suppliers Roof Tile Suppliers Roofing Insulation Rooflights / Skyl... Slate Roof Tiles Slate Roof Underlays Waterproof Roof C... Waterproof Roof I... Weatherproof Roofing Sustainable Const... Sustainable Energ... Sustainable Floor... Sustainable Plast... Sustainable Water... Anti Slip Timber ... Bespoke Timber / ... Bespoke Timber Bu... Contemporary Slat... Deck Board Flooring Decking Balustrad... Decorative Timber... Decorative Timber... External Timber P... Garden Trellis De... Hardwood Decking ... Internal Timber P... Oak Flooring Oak Framed Buildings Outdoor Timber De... Recycled Plastic ... Timber Timber Bridge Dec... Timber Bridges Timber Building S... Timber Ceilings Timber Cladding F... Timber Cladding S... Timber Conference... Timber Decking Co... Timber Engineering Timber Frame Cons... Timber Garden Bui... Timber Garden Fur... Timber House Cons... Timber Product Ma... Timber Rafters Timber Retaining ... Timber Roof Const... Timber Roof Trusses Timber Screening ... Timber Staircase ... Timber Structural... Timber Tree Houses Tongue and Groove... Tongue And Groove... Tongue and Groove... Western Red Cedar... Wood Care Products Wood Care Special... Wood Preservatives Wood Suppliers Wooden Carvings Wooden Floor Impo... Wooden Footbridge... Oak Flooring Parquet Flooring Hardwood Flooring Photovoltaic (PV)... Small Scale Wind ... View More
Benfield ATT Group:
Houses, Flats & more up to 7 floors – Special components & features, Garden Studios, Annexes, Traditional post & beam
Extend, Remodel, Build New | Trusses & Components
Helping Construction Professionals to Develop Sustainably & Profitably
Our 'SolidLox' range of Ancillary buildings is the perfect solution to adding more space to your home by utilising your outside space. Whether it be for a Garage, Carport, Summerhouse or even a Home Office. SolidLox is a flexible, cost effective solution to traditional Post & Beam construction. You can choose from standard off the shelf models through to FULLY bespoke designs to ensure you get the exact building you want.
Building your own home or extension can be met with many challenges along the way. We can take you through the entire process from design to construction. Leaving you to enjoy building your dream without the stress.
Our timber frame extensions are fast to erect and not weather dependent like 'wet build' masonry, so your life will be less disrupted while your project is taking place. A watertight shell can be constructed in only a few days.
From standard kits to fully bespoke designs you will find a timber frame extension for you!
Imagine getting planning permission, clearing your site and getting your new development up and sold in one quick easy process. Sound easy?
With Benfield ATT Group it's reality.
We design, make & build LOW ENERGY HOMES. Choose bare kits, Completed Shells, Full Turnkey Homes, Feature Trusses, Garages, Carports, Porches and Balconies, Park Homes.
At Benfield ATT Group we recognise that our true strengths lie in the knowledge and experience of our dedicated team of professionals.
Whatever your project …Wherever it is located …Talk to us first.
You'll be glad you did.
Do you spend too much of your valuable time on tasks that keep you from doing the thing you love to do - DESIGNING ?
Take the stress out of the Planning Application & Building Regulation Approval processes. Gaining Planning Permission can be one of the most frustrating and drawn-out processes of any build. Architects, landowners and builders hire us to take care of as much, or as little, of the process as they want saving themselves the hassle. From initial design assessment through to full application management there is a service for you. Let us deal with many of these chores for you.