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Personalised or packaged tours of the beautiful Upper Hunter Valley.
Discover the hidden gems of Upper Hunter Country with Upper Hunter Country Tours and Events. A fully guided tour with us could include wine tasting at local wineries, visiting horse studs, long, lazy lunches, hikes through our stunning rainforests and exploring the breathtaking secrets of the Barrington Tops.
Your tour will be led by leading tour guide Geoff Lloyd. Geoff is passionate about the Upper Hunter Valley and his unique knowledge of the area will ensure a trip you will remember for years to come.


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Last modified 5 February, 2017
Boblandstrom.com Privacy Policy
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Boblandstrom.com provides information, content, training and tools to users around the world. Our Privacy Policy helps explain our information practices.
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subset: commoncrawl


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<< Back to Parking Lots
Address: Viale Marche, Milano
Car park type: underground multi-storey (- 2 storeys)
Number of spaces: 387 + 30 for women + 9 disabled *
Opening hours: every day from 6 am to 1 am
* Disabled users whose vehicle displays a disabled permit for circulation and parking can park free of charge in the spaces reserved for them inside the car park.
Standard Rate
Applies from 7 am to 8 pm
1.00 € up to 4 hours
1.60 € up to 8 hours
2.10 € over 8 hours
Supplementary Rate
0.50 € from 6 am to 7 am
0.50 € for every hour or fraction of an hour between 8 pm and 1 am
Overnight Rate
6.20 € for the whole night from 8 pm to 7 am
Special Events Rate
1.60 € for day-time events
2.60 € for night-time events
Long Term Rate
6.20 € weekly, valid from Monday to Saturday from 7 am to 8 pm
Weekly passes are reserved for customers that have the Itinero Card and a valid ATM Travel Card. The weekly passes can be purchased from the ticket machines of the Car Park from Wednesday to Sunday before the week of use.
335.70 € quarterly
671,40 € six-monthly
1.343 € yearly
These passes can be purchased from Car Park operators directly. The passes can be issued in every moment and are valid from the moment of your collecting for 24 hours a day.
We remind that the parking bay is unattended. ATM does not accept responsibility for thefts or damages to vehicles
<< Back to Parking Lots


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That's how many people joined you in calling on Congress to Investigate FBI and DHS political spying.
Yesterday, we delivered those thousands of petition signatures, including yours, to the Senate and House Judiciary Committees in person. They were impressed!
Congress is listening to you, but it's going to take even more to get them to act. That's why we need you to do one more thing right now.
Can you contribute $25, $50, $100, or $500 today?
This campaign is just getting started:
We are working with grassroots activists like you to organize in-district meetings with key members of the Judiciary Committees.
We are bringing members of groups spied on by the FBI to tell their stories to Congress.
We are organizing public forums in key Congressional districts
We are building a coalition of 131 national and local organizations make Congress understand they must Investigate the FBI.
But we need your help to accomplish this. That's why we asking you to donate $25, $50, $100, or $500 today.
We want to make sure Congress hears your voice. Help us amplify it.
Stay Loud, Stay Strong,
Chip Gibbons
Here's what some of our coalition partners are saying about FBI spying:
"When Walmart workers like me started speaking out, Walmart considered it enough of a threat that they hired military contractor Lockheed Martin, contacted the FBI, and monitored our activities. No worker anywhere should be spied on for simply speaking up for a living wage. That's why we won't let Walmart intimidate us from continuing our stand up for $15 an hour, full-time hours, and being treated with respect." — OUR Walmart leader Cynthia Murray, who works at the Laurel, MD Walmart
"The spying on political groups like SOA Watch, Black Lives Matter, and Occupy unmasks the true nature of the FBI as a political police, whose role is to defend the status quo against political dissent." — Hendrik Voss, School of the Americas Watch National Organizer
"Our union knows all too well the tremendous damage done to democracy, people's lives, and the living conditions of the American people when U.S. government agencies are allowed to interfere with First Amendment rights. We fully support a thorough investigation of our government spying upon and infiltrating U.S. organizations carrying out lawful political activity."– United Electrical, Radio & Machine Workers of America (UE) Vice President Carl Rosen
"The Council on American Islamic Relations (CAIR), the nation's largest Muslim civil rights and liberties organization, stands with the seventy-five thousand Americans calling on the U.S. House and Senate Judiciary Committees to immediately investigate and hold congressional hearings on alleged FBI and DHS abuse of counterterrorism resources to spy on the First Amendment protected activities of civically engaged American citizens lawfully organizing, rallying and petitioning their government." — CAIR Director of Government Affairs Department Robert S. McCaw.
"Dissent is not the enemy of democracy. The FBI and Department of Homeland Security should not use their counterterrorism authorities to spy on domestic protest movements and activist networks. Congress must take immediate action to rein in these blatant abuses of power." – Demand Progress' Kate Kizer
"Five years after we occupied Freedom Plaza in Washington, DC, the problems of corruption in our government, rule by Wall Street and growing wealth inequality persist. The government has failed to address these injustices. It is time for Congress to investigate spying on peaceful demonstrators and make sure that our rights to political free speech are respected and protected." — Popular Resistance Co-Director and Maryland Green Party US Senate Candidate Margaret Flowers
"Isn't it funny how even the stripping away of our freedoms is defended as being done in the name of "Freedom"? If the emperor is ever spotted as having no clothes, he will probably have an FBI badge pinned to his skin." — RootsAction.org Campaign Coordinator David Swanson
Comments are closed.


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Coronavirus Update:
For the health and safety of our community, at this time we are recording our weekly liturgies for your viewing from home. Liturgies will be available at the link below by 11:00am Sundays.
Click here for our weekly Sunday Liturgy.
Please join us as we gather each weekend to celebrate the Lord's Day. On Saturdays at 4:30 p.m. or on Sunday mornings at 8:15 and 10:00 a.m. we are formed anew as a community of faith as we share the Word of God and are nourished together at the Table of the Lord.
As the seasons unfold throughout the liturgical year, we observe the Church's Holy Days and Feasts at our special liturgies or at other prayer experiences such as our All Souls Evening Prayer, Thanksgiving Day Mass, Advent Evensong or Lenten offerings such as the Way of the Cross or Taize Prayer.
Our intimate worship space provides a place for us to experience community and establish or renew our connection with each other. We strive to be a hospitable and inclusive community that involves parishioners of all ages. Our worship space is accessible to those with physical challenges and devices are available to assist those with hearing impairment. Hospitality gatherings after masses provide time for further deepening of our relationships.
Our weekend Masses are also the occasion for community celebrations of Baptism, Anointing of the Sick, RCIA and Confirmation, blessings and other moments that mark the important transitions in the lives of our members.
The Sacrament of Reconciliation is available on Saturdays each week from 3:45-4:15 p.m. and at additional times during the seasons of Lent and Advent. The entrance to our Reconciliation Room can be found in the southwest corner at the rear of our worship space.


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Purveyors of cool and savants of style, this is your new car. It's a Fiat 500L Beats Edition, and unfortunately for you, it's not coming your way for 2014. Unless you live in Europe, that is.
Mechanically, it's still a shapely Italian hatchback, albeit with the addition of two new engine options: a 1.6L MultiJet turbodiesel and a 1.4L T-Jet gas four-cylinder – surely you didn't expect Dr. Dre to stuff a Hemi under there, though we wish he had.
Inside you'll find the Beats premium sound system, developed and tuned by Dre himself, which is available with any of the three engine options, mated to Fiat's six-speed manual. It might be a bit of a gimmick, but one thing is for sure: You'll hear this thing well before you see it.
Despite the odd design of the engorged 500L, this special edition is one you'll want to see in person. The two-tone paint scheme looks nearly as fierce as the Abarths, with the black and grey exterior done-up in either a matte or glossy finish. And if Italian fashion is your fancy, the Beats Edition 500L dresses up with chrome outlining the rocker panel and accents of crimson on the seats and brake calipers.
RELATED: The Fiat 500 1957 Edition is Retro With a Retro Paint Job
RELATED: Bob Dylan and the Chrysler 200 Make the Most American Super Bowl Commercial
[via Fiat]
Also Watch


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Journal Information
Full Journal Title
|Publishing Approval
|Minister's deputy office in press and publicity affairs of the ministry of health and medical education according to certificate number 700/1179 on 24 May 2011 as an international medical journal
|Scientific Research Approval
|The Iranian committee of medical science journals of the ministry of health and medical education according to certificate number 100/268 on 26 May 2012 as scientific research medical journal
|Aim & Scope
|Thrita is an international, peer-reviewed, open access, a quarterly journal founded by Prof. Parvin Pasalar. Thrita is the official journal of Kowsar Corporation in scientific collaboration with Tehran Medical Research Centers Network. Kowsar Corporation acts as a science, technology, and medicine (STM) publisher which publishes more than 45 journals in different fields of sciences. Tehran Medical Research Centers Network is an academic organization that includes Scientific Research Centers of 8 medical universities of Tehran.
|Content Coverage
|Thrita is a journal dedicated to the latest research and findings including original manuscripts, meta-analyses and reviews, health economic papers, debates, and consensus statements of medical science those performed by medical scientists all over the world.
|Abbreviation Title
|ISO: Thrita | JCR: THRITA
|Print: 2352-0612 | Electronic: 2352-0620
|Journal Country/Territory
|The Netherlands
|Type of Publishing
|Article-Based Publishing (Continuous)
|Indexing Sources
|Complete list of indexing sources
|Article Submission/Processing Charge
|There is no article submission/processing charge in this journal. Online: Open Access; Article Acceptance Rate: refer here
|Digital Archiving Policy
|This journal deposits its articles in Portico to guarantee long-term digital preservation.
|Peer Review Policy
|Single-Blind Peer Review System AND Open Peer Review (since Aug 2019)
|Open Source Policy
|Refer here


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Jason deCaires Taylor is an internationally acclaimed eco-sculptor who creates underwater living sculptures, offering viewers mysterious, ephemeral encounters and fleeting glimmers of another world where art develops from the effects of nature on the efforts of man. His site-specific, permanent installations are designed to act as artificial reefs, attracting corals, increasing marine biomass and aggregating fish species, while crucially diverting tourists away from fragile natural reefs and thus providing space for natural rejuvenation. Subject to the abstract metamorphosis of the underwater environment, his works symbolize a striking symbiosis between man and nature, balancing messages of hope and loss.
Taylor's sculptures change over time with the effects of their environment. These factors create a living aspect to the works, which would be impossible to reproduce artificially. As time passes and the works develop biological growth, they redefine the underwater landscape, evolving within the narrative of nature.
The Silent Evolution "our favorite " (2010), forms a permanent monumental artificial reef in Mexico. Occupying an area of over 420 square meters and with a total weight of over 200 tons, it consists of 400 life-size casts of individuals taken from a broad cross section of humanity and has been designed to aggregate fish and corals on a grand scale. Slowly but surely these sculptures are evolving, a fur of algae on a girl's cheek, a starfish on a nun's face, The Silent Evolution reveals the imperceptible changes of nature on human artifice. Eventually this underwater society will be totally assimilated by marine life, transformed to another state—a challenging metaphor for the future of our own species. You can see most of his work here
Over the past few decades, we have lost over 40% of our natural coral reefs. Scientists predict a permanent demise of 80% by 2050. Jason de Caires Taylor's art is an example of generative human intervention in the ecosystem, showing what can be accomplished by individual imagination and collective effort. Taylor's strategy of conserving reefs, opposes the "land as commodity" mentality of Capitalism. His creation of underwater sculpture parks attracts tourists away from natural reefs, allowing them to recover, and taps into tourism revenue, showing how activists might be able to use the system's rapacious tendencies against itself. His exceptional works are designed "to promote the regeneration of marine life and to use sculpture as a means of conveying hope and awareness of the plight of our oceans" before it is too late.
You can find them in the waters surrounding Cancun, Isla Mujeres and Punta Nizuc.


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17 Facts About Peru You Probably Didn't Know
Peru is one of the most fascinating countries in the world with breathtaking natural landmarks and a distinct culture. From the mysterious Machu Picchu to the humble ceviche, there's tons to do in Peru.
If you are planning a trip to the Land of Incas, perhaps a lesson in Spanish will hold you in good stead. Try this quick start course on Spanish to get started.
On that note, let's take a look at 17 of the most incredible facts about Peru.
Fact 1: The capital of Peru is Lima.
It was established in 1535 by legendary Spanish conquistador Francisco Pizarro. Lima has a population of nearly 9 million and ranks as the fifth largest city in North and South America combined.
Fact 2: The National University of San Marcos in Lima is the oldest continuously functioning university in the Americas.
It was founded in 1551. Harvard University, the oldest university in United States, in contrast, was founded only in 1636.
Fact 3: Mashed potatoes, French fries and chips – all of your favorite snacks owe their origin to Peru.
This is where the humble potato was first domesticated. When the Spanish conquistadors conquered the Inca Empire, the first thing they exported to Europe was the potato, where it was quickly adopted as a cheap, easy to grow food crop.
Today, the world produces a whopping 374 million metric tons of potatoes each year. The average person eats nearly 73 lbs of potatoes annually. McDonald's alone buys 3.4 billion pounds of potatoes each year in the US for its restaurants!
Fact 4: Corn has long been the staple diet of Peruvians.
Today, Peru produces more than 55 varieties of corn in a wild range of colors, from the staple golden-yellow to striking purple, white and even black.
Fact 5: Guinea Pigs may be adorable, docile pets in the US, but in Peru, they are an important source of food and feature heavily in Peruvian folklore.
Don't be surprised if you see Guinea Pig meat (called cuy locally) on sale in Peruvian restaurants!
Fact 6: Peru has the second largest segment of Amazonian rainforest.
In fact, nearly 60% of the country is covered by rainforest. It is second only to Brazil.
Fact 7: Peru has been home to dozens of cultures throughout its history, though none were as impressive or as extensive as the Incas.
At its peak, the Incan empire was the largest in pre-Columbian America (i.e. Americas before the appearance of Europeans).
Remarkably, the Incan Empire was based almost entirely in the Andean mountain range, where both construction and farming were extremely difficult. Yet, the Incas created some of the most impressive cities known to man. Francisco Pizarro, who conquered the Incas, had this to say about the Incas:
"We can assure your majesty that it is so beautiful and has such fine buildings that it would even be remarkable in Spain"
Fact 8: The city of Machu Picchu, one of the most famous landmarks in Peru, was voted in 2007 as one of the New Seven Wonders of the World.
This city was built in the 1450s but was abandoned after a century. It lay undiscovered for nearly 400 years until Hiram Bingham stumbled upon it in the wilderness of the Andes in 1911.
Fact 9: Peru has three official languages – Spanish, Quechua and Aymara.
Both Quechua and Aymara were derived from ancient Incan languages. Today, roughly 84% of the population speaks Spanish, 13% speaks Quechua, while just 1.7% speaks Aymara.
Heading over to Peru? Pick up some beginner's Spanish to make the most of your journey!
Fact 10: Peru celebrates its independence from the Spanish Empire over three separate days, collectively called Fiestas Patrias ("Patriotic Holidays" in Spanish).
These three days are called the 'Countrymans Day' (June 24), the 'Peruvian Independence Day' (July 28) and the following day (July 29) to celebrate Peru's armed forces and national police.
The Fiestas Patrias are among the most important national holidays in Peru and the whole country shuts down in celebrations.
Fact 11: Peru is a surfer's paradise, thanks to the twin towns of Chicama and Mancora near Trujillo city.
Chicama boasts the world's longest left-handed wave measuring 4km, while Mancora lays claim to hosting the largest left-handed point break in the world. If you enjoy surfing, you can't not visit this surfer's paradise!
Heading to Chicama for a surfing trip? Then check out this course on Spanish for surfers and students!
Fact 12: The Grand Canyon may be vast, but the Cotahuasi Canyon near the city of Arequipa is actually the deepest canyon in the world.
With a depth of nearly 3, 535 meters, it is twice the depth of the Grand Canyon!
Fact 13: Peru is extremely rich in natural mineral reserves.
It is the third largest producer of all-important copper, fifth largest producer of gold, and leads the world in silver production. It is also the third largest producer of tin and zinc, and ranks fourth among lead producing countries.
Fact 14: Instead of a margarita or a martini, try our Peru's national drink, Pisco Sour for a change.
This cocktail consists of a grape brandy popular in South America, called pisco, along with lime juice, syrup, egg whites, Angostura bitters and ice.
This cocktail is said to have been invented by an American bartender, Victor Vaughn Morris, in the early 1920s in Lima, though similar drinks have been made in the country since the early days of the Spanish conquest.
Fact 15: The currency of Peru is called 'Nuevo Sol'.
It was adopted in the 1980s after the government was forced to abandon the Peruvian inti due to hyperinflation. Hyperinflation at the time was so bad that when Nuevo Sol was officially adopted in 1991, it was sold at a rate of 1 Nuevo Sol for 1,000,000 intis.
Today, the Nuevo Sol is a stable currency usually trading at $0.30-$0.40 for 1 Nuevo Sol.
Fact 16: Lake Titicaca located along Peru's border with Bolivia is the largest lake in South America It is also the highest navigable lake in the world with a surface elevation of 3,812 meters.
Large though it may be, Lake Titicaca is significantly smaller than the lakes in Great Lakes in North America. Lake Superior, for instance, has a water volume of 12,000 km3 while Lake Titicaca's volume stands at just 898 km3.
Fact 17: Thanks to the abundant rainforests and 90 distinct microclimates, Peru counts among the 10 most biologically diverse countries in the world.
It is home to 25,000 plant species – 10% of the world's total – and close to 5,000 species of fish and animals. It ranks first in the world in terms of distinct fish species (2,000 species, or 10% of world total), second in bird species (1,736 species) and third place for both amphibians and mammals (332 and 460 species respectively).
In fact, the Manu National Park in south eastern Peru recently set a biodiversity record after more than 1,000 species of birds, 1,200 species of butterflies and 287 species of reptiles were found in the park.
So there you have it – 17 incredible facts about the enchanting land of Peru! But before you hit the road and head to Lima, try taking a few Spanish lessons first to better understand the local culture. Check out this course on conversational Spanish to get started!
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Free 100-day returns and express refunds
We price match, and carbon offset every order
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CZ455 Scope Base
Area 419
If there is one area where the utmost precision is mandatory, it's scope bases. Literally the foundation for the scope or sight, anything less than perfection compromises the entire system. Seekins Precision Scope Bases are the perfect base mount for your Remington or Savage precision rifle.
Seekins Precision Scope Bases are full length rails machined from solid 7075-T6 aluminum to the 1913 Picatinny specification and Type III Hardcoat Anodized matte black. An integral recoil lug is milled directly into the scope base. This guarantees a rock solid mount by preventing any movement during recoil and eliminating stress on the mounting screws.
Scope bases are available 0, and 20 MOA to maximize the scope's elevation adjustment for extended range use and performance.
Grade 8 T-15 Torx fasteners are used to solidly mount the base to your rifle. Mounting hardware comes in #6-48 to fit Remington 700 patterned actions and Savage 10FP patterned action rifles.
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Anarchy Outdoors
Anarchy Outdoors


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My first neuroscience research experience was in eleventh grade, when I reached out to a lab at UCLA that used Transcranial Magnetic Stimulation (TMS) to study movement disorders. My mother had just started a repetitive TMS program aimed at reducing her depression and I sought to improve my understanding of the procedure by learning how to perform it myself.
From this initial research experience, I discovered that I truly enjoy being in an environment that fosters scientific innovation and creativity. Every lecture and discussion I attended acted as a reminder of just how expansive the field of neuroscience actually is, while every presentation I gave served to further instantiate myself in the world of neuroscience research.
A byproduct of this first research experience was that it also gave me an area of commonality with my mother. Suddenly I became her principal source for understanding the treatments she was undergoing. I was by no means an expert, but I had a background in the area and worked to increase that background over time by reading papers and attending lectures that pertained to her conditions. In this way, without meaning to, my mother inspired my passion for neuroscience and research while neuroscience and research helped me to reconnect with my mother.
With such a personal underlying motivation to do research, it is perhaps unsurprising that I remain as intrigued by the field of neuroscience now as I was in high school. Since this first research experience I have studied the lateralization of face-word processing in hemispherectomy patients and have researched the impact of different rehabilitation techniques on traumatic brain injury. I look forward to expanding the breadth of my neuroscience research experience over the coming year by continuing to investigate new areas of the field.


text: This seminar is designed to share information derived from brain imaging studies, about ways in which differences in the male brain and the female brain (no doubt also influenced by socialization) impact vision style and hearing. These two areas are at the roots of a great deal of gender heat and misunderstanding. Based on this information you can develop new strategies for communicating more successfully with the opposite sex.


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It bugs me that interest in electric cars is huge while rocket mass heaters are getting less than 1% of the attention. Don't get me wrong, I applaud the electric car. I just think interest in stuff about our heat would be bigger.
Walt Chase wrote:
Could you change your pot type/size/shape to match a commercially available one in order to be able to grow as mentioned in the above quote?
Joseph Lofthouse wrote:
That looks exactly like a measuring cup to me... Just awkward and slow because there are a whole bunch of measuring cups hooked together.
Joseph Lofthouse wrote:
Doesn't the weight per volume vary a lot depending on moisture content?
Cynthia Quilici wrote:Could you use cut-off versions of the plastic pots themselves as measures?


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"Twas Steve's idea..." said Stan Lee about Dr. Strange in a letter to Jerry Bails in 1963. However, it's interesting to ponder just what gave Steve the idea to do a strip about a 'Master of Black Magic' (later changed to 'Mystic Arts') in the first place.
Ditko had been the inker on the origin of Lee and Jack Kirby's strip, Dr Droom, and it's legitimate to wonder whether the artist may have been inspired (consciously or not) by this earlier character, whose genesis is remarkably similar to that of Stephen Strange. That would explain the subject matter, but not Ditko's seeming lack of interest in revealing the origins of the good Dr S, who, in his very first adventure, is plunged straight into an encounter with Nightmare, his "ancient foe". Stan merely adapted Droom's beginnings to fit the origins of the protagonist he was initially going to call Mr Strange, not Dr, but his input into Strange's backstory, as well as his characterisation via dialogue, plus his mood-setting expository captions, fully justifies his description as co-creator of the strip in my view.
After all, without Lee, all you have is a magician who gets involved in some quirky adventures (Ditko's wonderful art notwithstanding); with Lee, you have character motivation, mystical sounding incantations, and a sense of drama, dynamism, and danger as only he could deliver.
That's not to downplay Steve Ditko's plotting and art, though - it's just that he wasn't much of a scripter, as his later self-penned stories for other companies starkly demonstrates. His plot ideas, however, were often brilliant. Case in point: Who can forget the 12-part saga of Dr Strange on the run from a Dormammu-enhanced Baron Mordo, surely one of the most spectacular sagas of the Silver Age? However, while Strange's origins are lifted from Dr Droom's, the strips are not really that similar when more fully compared. In fact, Droom (who debuted in Amazing Adventures 1 in June 1961) soon gets sidetracked from the world of the occult, as his subsequent adventures (2, 3, 4 and 6) have him encountering aliens from under the sea, different dimensions, and other planets.
In his origin, the Tibetan Lama who gives him his powers declares "You are now the nemesis of all occult powers that are sinister and corrupt!" However, in his third outing, after defeating an alien from Saturn called Zemu, he declares, in answer to what made him suspicious of his disguised (as a human) foe, "It was his boast of having real magic powers!" He goes on, "I, of all men, know that real magic does not exist! All is illusion! All is fantasy!"
|In Amazing Adventures 2 (Jul 1961) Dr Droom investigates the disappearance of an ocean liner and discovers it has been abducted by the sub-marine inhabitants of Atlantis, who bear no resemblance to Prince Namor or his people.
So, despite similar beginnings, the two series have only a superficial resemblance to one another. Interestingly, when Dr Droom passes the Lama's tests of endurance, his eyes become 'slanted' (to use the terminology of the times), as an Oriental appearance is supposedly more suited to his new role in life.
|No political correctness in sight here - Dr Droom's skin colour and features are altered to better match his new role as a master of the mystic arts.
|The Droom adventure in AA3 (Aug 1961) pits Droom against another magician, who turns out to be an alien from the planet Saturn, using advanced science to simulate mystic feats.
In case you were worried about him, Dr. Droom reappeared in the '70s (first in reprints, then as a guest star in other titles), but was rechristened Dr Druid to avoid confusion with a Latverian Doctor with a similar name. He even became a member of The Avengers for a while in the late '80s.
However, let's not skirt around the controversy that you 're all wondering about. Didn't Stan Lee claim to have created Dr Strange in his 1974 book Origins Of Marvel Comics? How does that gel with Steve Ditko's assertion that he plotted and drew the first Dr S tale without any input from Stan?
|Amazing Adventures 4 (Sep 1961) had Droom combat alien invaders once again, this time convincing the extra-terrestrials that a construction site wrecking machine was a sentient lifeform. For a magician, Droom wasn't doing a whole lot of magicking ...
In 'Origins' he reminisces about listening as a kid to a radio show called Chandu, The Magician, which had a gong with a resounding 'Bonnnggg' in the intro, then says "Anyway, Steve Ditko once again took up the art chores while I penned the words, and before you could say 'Who needs it?' Dr Strange was born. He was a magician, and if ever we do his stories on the radio, you'd better believe he's gonna have a gong!" (No radio show alas, but we now have a big-budget movie instead.)
I think Stan's vagueness on the matter is probably down to his poor memory, rather than him trying to deliberately misdirect credit away from Steve, as, had he been a liar as some of his detractors prefer to believe, he'd surely never have admitted to Jerry Bails in 1963 that he hadn't come up with the idea himself.
Anyway, regardless of who did precisely what, Dr Strange as he first appeared to the comics-reading public was the joint result of Stan, Steve, and Dr Droom, so all three deserve our undying thanks. And I'm sure Benedict Cumberbatch feels the same as he looks again at the cheque he received for bringing Marvel's Mystic Master to life on the big screen. When last seen, Dr Droom/Druid was heard mumbling, "It's not fair! It should have been me up there! It's an injustice it is!"
Now how do I wrap this up? Ah, what the hell, I can't stop myself - "May your amulet never tickle!"


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0.47 CT. T.W. Men's Diamond Ring in 14K Gold
Product Details
About this item
- IGI appraisal value $1,200
- Metal: 14K White or Yellow Gold
- 7.91MM (widest part of the band)
- Diamond Weight: 0.47 ct. t.w.
- Diamond Quantity: 7 round cut diamonds
- Diamond Color: H-I
- Diamond Clarity: I1
- IGI Certified
- Available in whole and half sizes 8.5-13
Premium Craftsmanship & Materials
Our jewelry is finely crafted in high quality 14 karat gold for elegance combined with durability. We control our quality management from beginning to end - this includes the purchase of raw materials through final delivery of the product to your home. All of our precious metals and diamonds are from certified sources recognized for their supply chain control. IGI certification is accompanied on all diamond products.
Product Design & Development
We specialize in innovation surrounding material development, production, manufacturing and design. We oversee the entire process from Sketch to CAD to Production, ensuring you receive a beautiful final product! Our Product Development Team is best in class and designs styles specifically for Sam's Club Members.
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We are proud members of the Responsible Jewellery Council. All of our precious metals and diamonds are from certified and audited sources recognized for their total supply chain control.
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- Round Diamonds
- H-I Color
- I1 Clarity
- IGI Certified
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Book Description
This Element is an excerpt from Make More, Worry Less: Secrets from 18 Extraordinary People Who Created a Bigger Income and a Better Life (9780132346863) by Wes Moss. Available in print and digital formats.
If it doesn't terrify you…maybe it isn't worth doing!
We usually try to avoid that sick, nervous "butterflies-in-the-stomach" feeling. But Ralph Stayer owes his career success–and the success of hundreds of employees–to chasing that butterfly feeling. "If the things you commit to don't make you puke in the sink every now and then, you really haven't signed on for a lot," says Ralph. That's how he built his career at Johnsonville Sausage.
Table of Contents
Product Information
- Title: The Butterfly Effect: Getting Beyond Your Comfort Zone Brings Success
- Author(s):
- Release date: March 2010
- Publisher(s): Pearson


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Trends: dialogue between fashion and makeup in France
At the first edition of the MakeUp in Sao Paulo trade show, Hélène Capgras, Director of creative consulting firm Brain for Beauty, explored the great sources of inspiration of the French cosmetics industry, and in particular the role of fashion in the development of the most famous makeup brands. And the question was: what inspirations for Brazilian cosmetics brands?
"Historically, the authority and energy in the makeup world come from couture, which served innovation," started Hélène Capgras.
Fashion shows and makeup trends
As soon as the 1980s, Dior showcased seasonal looks with shades and colours inspired by the world of couture. But it was John Galliano who created a real synergy between fashion shows and makeup over the 1990s and the 2000s. For example, his African influence on catwalks began to reflect on colours, and the first Diorific lipstick launched showed a brown shade.
Then Chanel came up with the idea of the star product. Fashion evolved towards the must-have "it product", and makeup took inspiration from these dynamics.
The world of brands
However, drawing inspiration from fashion also meant innovating, both in the packaging and content. Brands saw it as an opportunity to remind of the codes of fashion houses. Yves Saint Laurent bows started to appear, and the Dior bag was featured on the packaging of makeup products. Chanel also introduced its fashion semantics into the world of complexion products: the well-known Blanc by Chanel was inspired by camellia and pearl and, more recently, beige, the favourite clothes colour, was used to highlight nude ranges.
Interpreting femininity
Then it was the image of women interpreted by each fashion house that started to reflect on the makeup world. The Maison Dior illustrated the different femininities in its imaginary with Natalie Portman, icon of Rouge Dior and embodiment of the young beginner, or with the image of the Hollywood blonde in J'Adore campaigns. With YSL, women looked strong and wore suits: this idea can also be found in the packaging of the Touche Éclat pen presented as a gun.
New players
Today, great French fashion houses open their own beauty and makeup stores in the iconic shopping streets of Parisian couture, like Rue Cambon or Avenue Montaigne. But ready-to-wear or accessories designers are now seizing the beauty world in turn. Luxury shoe maker Christian Louboutin launched his own nail polish line in 2010, and underwear manufacturer Etam has just launched his own beauty range.
Colour trends, distribution, styling, social networks… there are more and more links between fashion and makeup, and whether they come from couture or not, most brands cultivate these dynamics to develop.
For Hélène Capgras, the French example can be highly instructive and already represents an interesting prospective approach for Brazil, where the fashion identity is already widespread.


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I usually clear out my clothes as I'm a bit of a sale shopaholic and get easily tempted to buy things I don't even need.
Earn & save money by decluttering your unwanted stuff at home. Sell them around such as as carboot, garage sale or online. Make a clear out to create a new space at home that is more pleasing to eyes plus selling them means you can have a bit of extra money to save for something you really need. It's a good way to clear out your stuff. You get inspired more if you get rewarded a bit, so keep calm and start decluttering.
Sites and app for selling your stuff when decluttering.
Facebook – Tried and tested. clear out and sell by joining lots of selling group locally. This way you don't need to pay fees to site such as eBay n PayPal etc. People will come and collect it from you and pay cash. But beware of time waster people and don't let anyone you don't know at your house. Always give the item at your door. Furniture and household stuff do sells very quickly here. Also once you uploaded picture you need to constantly advertise it by bumping to keep your listing back on top just by commenting. People are usually more online at night time.
Vinted- this is an app. Tried and tested. 15 percent fees to pay when selling here. You can sell or swap as well but beware of scammers. I got scammed here few times by swapping so just selling now but also got good swap before. Clothes and accessories for all gender and age.
Depop- this is an app. Tried and tested. Instagram style, gain attention from following and liking items. Quick and easy to upload. 10 percent fees to pay here.
Shpock- this is an app. Tried and tested and free to use it unless willing to pay. You can post or buyer to collect locally.
eBay- I would say one of the best. tried and tested and loads of audience as can be viewed worldwide and easy to sell but only few profit after all the eBay and PayPal fees that being invoice monthly. It's better to be a private seller and take advantage on free listing being offered sometimes and take note once you list your item do not put the option " automatically relist your item " bcos I've learn this is where I got charge loads from the insertion fees.
Happy sale – this is an app where you can list for free. Tried as tested and sold here few times. ( I think it's gone now as can't find on Apple Store anymore )
Consignment shop- tried and tested. Perfect if you have one locally to your place. This is a shop where you can take your clothes and they will choose what to stay in there shop for let's say 1 month and if your stuff does get sell then you split it 50-50 so you get paid either cash or cheque but every consignment shop is different so ask their policies and procedure in dealing.
Hope this will help you to get inspiration in clearing out your stuff. Thank you for reading 🙂


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Sport Cap is rated out of 5 by 333.
Klean's Sport Cap features a soft silicone spout and improved valve. We've kept all the features you love; dishwasher safe, attachment loop, and one-handed operation—adding quieter performance, better leak resistance and 25% higher flow rate. Compatible with Classic Klean Kanteens only.
- Soft silicone spout
- Spill proof, high flow
- Cap is not designed to be leakproof
- Handy attachment loop
- Dishwasher safe
- Compatible with Classic Klean Kanteens only
|1.5 ounces (42.5 g)
|2.875" H x 2.5" W (73 mm H x 63.5 mm W)
|Not for use with hot beverages
Child Safety Warning: Sport Cap 3.0 not intended for children 3 and under. Not intended for chewing or teething. Always use this product with adult supervision. Always ensure the silicone valves are properly installed. Adult assembly required.
Related Products
Rated 4 out of 5 by txgrll from Good cap and great gift idea I ordered this cap alongside an insulated 12 oz bottle and have enjoyed it so far. I might offer a suggestion to improve the cap. I tend to use the bottle and cap alongside a small pack that I carry daily. I don't carry a purse because of issues with my hip and my pack has a pocket for the water bottle. One day, I had a sip of water and did not properly close the cap, causing it to spill on my pack. I would suggest perhaps an indicator on the cap to show that its closed; maybe a white line under the tip, where it meets with the rest of the cap so when its closed, the line disappears and vice versa. Unless you push down on the tip of the cap, then you are not sure whether it is fully closed.
Date published: 2016-12-22
Rated 3 out of 5 by Mad L from Not very practical I got this about 2 months ago, I am on the go a lot and wanted a lid that would be easy to take a quick sip out of and keep going. This cap was good for that but the challenge came when I needed to close it. If my hands were dirty or just not freshly washed I never wanted to close it with my hands because the part where your mouth touches is exposed. So I ended up having to close it with my teeth(I know weird). Also whenever my bottle would tip over the mouth piece came into direct contact with the dirt, mud, grass, dirty gym floor or any other surface. Great quality product just not thought out. A little dust cap would be great for this.
Date published: 2020-07-23
Rated 1 out of 5 by Diane from Silicone sport cap is terrible, especially for kids! I bought one of the older Kleen Kanteen's that had the all plastic spout with lid many years ago and never had a problem, it was amazing! I decided to buy 4 more for the rest of my family and unfortunately they were the silicone ones. After about a year of my kids opening the lid with their mouths (because it would be unsanitary to open it with their dirty hands and drink from it), 2 out of 4 silicone spouts have completely come off. Now, they have to take off the lid just to drink from it. I wish they would make the all plastic ones with the lids! I'm deciding wether to get another brand, like the Life Factory with active flip cap, or just replace the Kleen Kanteen sport cap with their loop cap. For kids, it's always better to have a flip cap, though.
Date published: 2018-04-14
Rated 5 out of 5 by mvanvoorst from So far, so good! I bought my two kids and I new sports caps. We had the old versions and my 3 year old son had even destroyed his mouthpiece by a bad chewing habit. I loved that we got to pick out colors. It makes the kids more invested in their water bottle and apt to drink more! We got them just before our spring break trip to the Oregon coast and on the long card ride I was pleased with the way they don't leak when properly closed. What I love the most, and might sound silly, but is how much gulp factor I get per pull...if that makes sense! When I'm thirsty, in dance class or between classes I just need to get water down the hatch and I love it.
Date published: 2019-04-15
Rated 1 out of 5 by GHope from Sport Cap 3.0 I'm very disappointed with this new cap & very sorry I wasted money to purchase 3 of them. I have more than a dozen Klean Kanteen bottles that my family loves with the old sports caps. The only problem we had with the old ones was the noise when we drank & while these new ones don't make that noise they steadily leak & are much more difficult to clean. I was able to lay the old ones down to stack them in a small fridge & assumed I'd be able to do the same with the new ones but I cannot lay them down at all due to steady leaking & have to use q-tips to clean them. So much for the claim of being improved. I had to give one star for the rating only because it wouldn't allow my post without it, but these do not deserve even one star
Date published: 2018-06-24
Rated 1 out of 5 by SharonC from Awful We have an older kind that is all plastic and we LOVE it. But these newer silicone ones are awful. Not only are they difficult to open, food gets inside the top hole, there is gunk around the part that goes down inside when you close it (and no matter how much I try it won't come clean!), and the top silicone part is tearing after only being used for less than a year. Although disappointed to not find the same lid we had, we had high hopes for these. But we have been seriously disappointed.
Date published: 2018-02-01
Rated 1 out of 5 by JannetteS from All Caps Leak I have a sport cap, sippy cap, and loop cap, all of which I've tried on a 12 oz kids bottle and 40 oz bottle. Unless I close them so tight that they're very hard to reopen, they all often leak. On three occasions I ended up with a handbag / tote bag / shopping bag with water sloshing around inside, all contents soaked. This is not including the multiple other times I caught leaks before they got that bad. I'm not weak, always close the lid to a normal tightness but leaking often occurs unless I close the lids super tight. Will not repurchase.
Date published: 2018-07-19
Rated 2 out of 5 by AnnL from Sport Cap 3.0 I was disappointed in the Sport Cap 3.0. 1. There is no cover for the drinking spout to cut down on contamination either from the air or from your hands when closing the spout. 2. The bottle can't be carried in a gym bag or backpack without leaking. To remedy this I used super glue to plug the 2 little holes that actually help the flow of water but also cause the leakage. I prefer the old style cap that came with the bottle when I first ordered it several years ago. The plus side is that there is a stronger loop on the cap with which the bottle can be carried.
Date published: 2016-11-26


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"Nintendo blah blah blah blah"
June 6, 2007
Store: EB Games
Location: The Strip, North Canton, Ohio
Employee Description: Some big dude with dark hair
Submitted By: Neil Weakland
I was in need of a new AC adapter for my GameCube (don't ask why) so I went to an EB games to get a new one. As I was looking around for one, I heard the sales clerk telling a woman on the phone that the PS3 was going to retail for over 800 dollars and that she should look into a 360. This was before anyone knew how much the PS3 would cost. So after he was off the phone I asked him if they had a GameCube AC adapter, He told me that because Nintendo blah blah blah blah, they don't allow third parties to make AC adapters for the gamecube.
The next day I went to the EB games in Belden Village Mall (literally, like a mile and a half away) and bought a GameCube AC adapter from the company Intec.
New Nintendo series
June 5, 2007
Store: GameStop
Location: Dallas, TX
Employee: Mike Rotch
Submitted By: CockBlockingBeats
2002. So I walk into the store to reserve the new Metroid Prime and Metroid Fusion videogames. The employee and I get into a small conversation.
Mike Rotch: "Well it looks like Nintendo is finally adding a science fiction series to their other franchises. I'm looking forward to it."


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This past December, our team trekked up a remote, active volcano in Ecuador known as Sangay, "The Giver." We collected more than 60 geologic samples from lava flows and rocks all up and down the slopes, which will help us better understand the working of this and other volcanoes around the world.
One month after we departed, Sangay started erupting with ferocity again. This renewed activity, first detected by airline pilots, was captured in photographs from the Macas, Ecuador region and has been imaged by satellite, all seen below.
According to MIROVA (Middle InfarRed Observation of Volcanic Activity), which looks at MODIS (Moderate Resolution Imaging Spectroradiometer) data aboard the Terra EOM and Agua EOS satellites, since January 15, 2015, there has been detectable thermal activity at the summit of Sangay, with a multitude of thermal alerts with significant radiant heat emitting from its summit region (spanning from 1 to 10 MW). Significantly, at 03:20 (UTC) on Jan 26, 2015, a thermal anomaly of 75 MW was detected by MIROVA. This 75 MW thermal anomaly is the highest detected at Sangay since 2000, with the exception of an alert of 78 MW that occurred on 19 December2006.
In light of this renewed volcanic activity, obvious scientific questions are: What is next for Sangay? Will Sangay continue to erupt? Will it go back to its recent quiescence? Or even will its activity increase as seen in past years when the summit dome was developing?Sangay's summit dome erupted roughly 20 years ago. This eruption's solidified lavas were collected by our recent expedition. (Photo by Marco Cruz)
These new eruptions also query the superstitious mind: Was Sangay, "The Giver," being benevolent in December by allowing us to work unfettered and safely on its summit and upper slopes? Or were we just lucky? Who knows? One fact is certain: science is the beneficiary of our successful Sangay Expedition. Thank you again, National Geographic Society, for your continued support.


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Wedgewood RPM
14445 Highway 35
Minden Ontario K0M 2K0
Business Profile
Visit one of our three waterfront locations in Haliburton Village, Minden (Wedgewood) and now in Coboconk on Balsam Lake! Boat Rentals: Bowriders, Pontoons, Tinnies
Location: East Central Ontario Area
Categories: Boat Rentals
View other boat rentals businesses in the East Central Ontario Area.
Updated: 2018-07-20 08:53:46 ID: 265 Suggest an update to this business.
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Coney Island just got a little freakier!
Coney Island USA — home of the famed Sideshows by the Seashore — opened a weird new wing of its Surf Avenue headquarters on Aug. 23 with a show of dark and disturbing carnival arts.
Renowned bizarro maestros Todd Robbins and Zamora the Torture King put their terrifying talents on display in the new performance space — the former back room of frozen treat shop Denny's Ice Cream. Robbins extinguished matches on his tongue, swallowed swords, and showed off his shocking "human blockhead" act — driving a long nail deep into his nasal cavity.
Zamora went even further, with a punishing performance that involved fire-eating, lying on a bed of broken glass — with an attendee standing on his chest — and impaling his face and limbs with skewers.
"It's much more of an extreme, adult show than our usual performances," said freakshow founder Dick Zigun.
But the weak of stomach need not fear — Zigun said the space will be used for more than demonstrations of mutilation. The guru of the grotesque envisions his new "Arts Annex" also serving as a painting gallery, or a music venue or even a unicycling showcase. The idea, Zigun said, is to broaden Coney Island USA's repertoire.
"It lets us diversify and do a mix of things," Zigun said.
Zigun bought the building next to his corner spot at W. 12th Street in 2011, with the plan to expand his circus sideshow. But he decided instead to continue operating the Denny's Ice Cream stand — which had opened in 1978 — when he realized its revenue would help him pay the mortgage.
But superstorm Sandy licked the cone shop, destroying $50,000 of soft-serving machinery — equipment Zigun couldn't afford to replace. Zigun opened a restored antique shooting gallery in the storefront space earlier this month, after some remodeling.
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Spotlight on Lensmire Family Farm – Hydroponic Fodder Sprouts Savings
Lensmire Family Farm, owned and operated by Tom and Jane Lensmire, is home to about 80 Holstein, Jersey and Swiss dairy cows. Located in Cleveland, WI, the farm has been in the family for 23 years and spans 80 acres of land. The Lensmires began rotational grazing about 13 years ago and still use this practice today, in addition to purchased feed. However, an interest in hydroponics led them to FarmTek's Fodder-Pro 2.0 Feed Systems after reading about hydroponic fodder in the company's catalog.
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Where We Stand on Transportation
By AlexRobbins | May 16, 2012 | No Comments
In my very first post on this site I spoke about the Governor's short-term solutions on transportation and how inadequate those solutions were with the needs of the Commonwealth. The General Assembly was still in the middle of its session then and I was hopeful that, despite poor appearances, the Administration would eventually come around and see the necessity of providing for the transportation needs of northern Virginia, which benefit the entire state when all is said and done. The General Assembly has wrapped up its special session on the budget now and by all appearances we're in exactly the same place as where we started. If anything, we've even moved a little in the opposite direction.
As with all unfortunate situations, it bears reviewing how we got to this point and what could potentially be done to prevent it from happening again in the future. First there was the proposal to sell the naming rights to roads and bridges throughout Virginia as a way of generating extra revenue. This of course fell woefully short of what would be necessary to adequately fund all of Virginia's transportation needs. For some time it appeared as though this would be the only solution to come out of Richmond. Then came devolution. The seemingly revolutionary idea of letting the localities handle transportation issues on their own amounted to nothing more than an attempt by the state government to abdicate its responsibilities, effectively passing the buck to the localities without providing any assistance in terms of helping to pay for the costs.
Devolution's time in the spotlight was short-lived and soon enough we were back to square one. Firmly entrenched it would seem, with the passage of the state budget including the old proposition of selling naming rights. What's worse, we have seen no movement from the Governor with regards to taking a principled stand when it comes to transportation, an issue he promised to seriously address while campaigning. Indeed, the only campaigning that seems to have taken place in Richmond has been that of Republicans against ancient enemies in the realm of social issues. These agendas have even spilled over into non-germane areas, most recently exhibited by the Administration's refusal to provide the $150 million it is bound to provide for the Dulles Rail project over a disagreement over the use of unionized labor for the project. Three years after Governor McDonnell took office, there is still no sign of finding a dedicated funding source for transportation.
This represents a huge failure of leadership on the part of the Governor, who cast himself as a moderate but lately seems content to ally himself with the extreme right. We saw this earlier in the year when he failed to stop Republicans in the General Assembly from carrying out their absurd agenda focused on social issues rather than creating jobs and growing Virginia's economy. We are seeing it again now with regards to transportation. Instead of putting forward a serious plan to address the growing gap between funding for transportation and the actual demands of the state, in which no option was off the table (this includes tax increases), the Governor and the rest of the Republican Party seem content to put forward the same used-up ideas and hope that no one notices. They are in for a rude shock next year should this behavior continue. Virginia needs and deserves better from its elected leaders.
Disclaimer: The opinions expressed in this post are those of the author, and do not necessarily reflect those of members of the NDP Steering Committee.


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Bowel Inflammation
Autoimmune and chronic inflammatory diseases are a global health problem. With respect to the burden of inflammatory bowel diseases (IBD), approximately 1.5 million Americans exhibit chronic debilitating inflammatory conditions of the intestinal tract, leading to distressing symptoms and an impaired quality of life (with an estimated annual cost exceeding $2 billion).1 Patients experiencing IBD often report symptoms such as abdominal pain, diarrhea, rectal bleeding, weight loss, fever, and fatigue. Ulcerative colitis and Crohn's disease are two distinct forms of IBD.2 In ulcerative colitis, inflammation is typically restricted to the mucosa in the colon. In Crohn's disease, any area within the entire gastrointestinal tract may be susceptible to inflammation.
One in 19 Americans are at risk of developing colorectal cancer in their lifetime. Detection and removal of precancerous polyps has reduced the incidence and mortality of this disease.3 Patients with IBD have an increased risk for developing colorectal cancer; after seven years of inflammation, the risk of developing cancer increases by 0.5 to 1% every year.4 Although studies have shown this direct relationship between inflammation and colon cancer, early cancer detection remains a challenge, even for this high-risk population.5 Currently, high-risk patients are recommended to begin colonoscopy cancer screening at an earlier age than healthy adults.6
Epidemiologic studies have shown that diet is also a major risk factor for colorectal cancer.3 For example, high consumption of red or processed meats increases the risk of colorectal cancer by 28% and 20%, respectively.7,8 Recent studies indicate that bioactive food components containing n-3 polyunsaturated fatty acids (PUFA) may have antitumorigenic effects by reducing inflammation in an animal model of colitis-associated cancer.9,10 Data has revealed a "protective effect" of n-3 PUFA (fish oil) on colon cancer and in contrast, n-6 PUFA (vegetable oil) has been shown to amplify the formation of colon tumors. This may suggest that IBD patients could moderate cancer development by modifying their diet.11
Colon crypt and tissue structural changes in pre-clinical studies are typically characterized using histopathology. Histology provides images of cellular and tissue structure after animal sacrifice, colon removal, and washing and staining of the tissue. This is a time-sensitive process that can introduce artifacts during tissue preparation. In histological images of normal colon tissue, the cylindrical crypt openings are aligned parallel to one another and exhibit a uniform hexagonal pattern when observed from an en face view.12 This pattern is characteristic of normal colonic tissue with only slight variation in colon size and arrangement. Inflamed tissue varies in morphological structure compared to normal colon tissue. Crypt structure may be lost, and tissue architecture is replaced by a disordered crypt arrangement with heterogeneous crypt size and shape, which can be seen both in histology and confocal endomicroscopy.13,14 Due to the heterogeneity of inflamed tissue, examination of a small tissue sample by histology may not be indicative of the most severe disease state elsewhere in the colon. The 'swiss roll' technique may be used to visualize histological features along the length of the colon, but provides only a thin section through the tissue.15 With transition from inflammation to neoplasia, dysplasia or cancer can affect any part of the colon with various magnitudes at different locations, complicating localization and characterization of disease by histopathology in pre-clinical studies.5
Rapid imaging of bulk tissue along the length of freshly excised colon could provide sufficient information on crypt structure throughout the colon to characterize tissue in pre-clinical studies. Reduced tissue processing, fast image acquisition, and evaluation over a larger field could increase throughput and quantification in pre-clinical studies of IBD. Our custom-designed confocal microscope can achieve a single field of view image in 10 s. Compared to other confocal imaging systems, this system is capable of producing large area images in a short period of time. Here, we present stage-scanning confocal microscopy as a technique to rapidly image the length of the colon with minimal tissue processing.
Confocal Microscopy
Confocal microscopy can provide high resolution images of bulk tissue with minimal tissue processing and fast image acquisition. In contrast to the physical sectioning and two-dimensional imaging of traditional histology, confocal imaging allows "optical sectioning" of bulk tissue, enabling acquisition of three dimensional images of intact tissue.16,17 This technique has been translated to the clinical setting where in vivo confocal microendoscopy is currently being explored for guiding biopsy in the gastrointestinal tract.18 However, even with mosaicing to expand the imaging field, field of view (FOV) still remains limited.
The high resolution of confocal microscopy is achieved by placing a pinhole in front of the detector in a conjugate image plane of the focal spot in the sample. Out-of-focus light is significantly rejected by the pinhole. Two-and three-dimensional images can be generated by scanning the beam or the sample.19–21 Although historically, stage-scanning has been used quite extensively,22 the speed of translation stages has limited the speed of image acquisition. Modern confocal microscopes typically use some form of beamscanning to maximize image acquisition speed,23 but the FOV is typically limited to less than .24 A larger FOV can be achieved by stitching images together using a mosaicing technique.25
FOV and image acquisition speed can be increased by combining beam and stage scanning. Recently, beam and stage scanning used with mosaicing has been implemented to increase acquisition speed of large FOV reflectance confocal images for dermatological applications.26 A strip mosaic was acquired in 3 min. Similarly, spectral encoding in one axis to scan 180 μm and stage scanning in both lateral axes with mosaicing has been used to image large esophageal biopsy specimens.27 Axial scanning of the objective lens using a piezoelectric transducer allowed three-dimensional images over a 120 to 150 μm depth range. Fields of view ranging from to were acquired in 2.5 to 15 minutes. Large FOV fluorescence confocal imaging of the mouse colon and other organs in vivo through a gradient index (GRIN) side-viewing microprobe was recently achieved by versatile multidimensional scanning.28 The raster-scanned FOV is extended by mosaicing frames captured at 30 frames per second while rotationally scanning the microprobe and/or translating the sample or animal to scan along the length of a lumen. The focal depth position in the sample is adjusted by altering the focal position at the proximal face of the GRIN relay lens. 60,000 frames acquired in over 30 minutes from a 12 mm length of mouse colon after intravenous injection of fluorescent dye are reconstructed into beautiful images of the vasculature in two and three dimensions and with multiple scales.
We exploit a polygon mirror beam scanner and a fast motorized translation stage to rapidly acquire confocal images with an extended FOV in one axis. We have acquired a single high aspect ratio, 60-megapixel, image in 10 s, extending image size in one axis and increasing acquisition speed over previously reported systems. Translation of the sample in the third dimension allows three-dimensional imaging and two-dimensional projections of tissue to accommodate specimens with an uneven surface. This high aspect ratio imaging is ideal for imaging tissue structure along the gastrointestinal tract. We present the use of combined beam and stage scanning in confocal microscopy to extend the FOV to image and evaluate freshly excised mouse colon to provide qualitative information on crypt structure along the length of the colon.
Materials and Methods
System Design
Figure 1 shows a schematic of the constructed confocal fluorescence microscope [Fig. 1(a)] and a photo of the current setup [Fig. 1(b)]. The upright confocal microscope has a 40 mW, 488 nm, continuous wave, externally doubled diode laser (Excelsior, Spectra-Physics, Santa Clara, CA) for fluorescence imaging. The laser beam passes through a spatial filter, which also serves as a beam expander, and reflects off of a dichroic mirror (z488rdc, Chroma Technology Corporation, Rockingham, VT). A custom-designed polygon scanner (Lincoln Laser, Phoenix, AZ) with a scan rate of 2.5 to 8.75 kHz serves as the line scan, and a galvanometer scanner (6220H M40B, Cambridge Technology, Lexington, MA) with a scan rate up to 15 frames per second (fps) provides the frame scan for image acquisition in traditional raster-scanning mode, producing "square" two-dimensional images. Two telescopes are used to image both mirrors onto the back aperture of the , 0.8-numerical aperture, 3.5 mm working distance water immersion microscope objective lens (MRD07420, Nikon). The sample is positioned on an XYZ-motorized stage (KT-LSM100A, Zaber Technologies Inc, Vancouver, British Columbia, Canada) with 0.05 µm resolution, 100 mm of travel in each axis, and maximum speed. Fluorescence is excited in the sample, collected by the objective, passed back through the telescope system, and descanned by the scanning mirrors. After passing through the dichroic mirror to the detection arm, the signal is focused onto the confocal detection pinhole and then refocused onto a photomultiplier tube (PMT) detector (H9433-03MOD, Hamamatsu, Bridgewater, NJ) with gain set to and frequency bandwidth of 10 MHz. A frame grabber (NI PCI-1410, National Instruments, Austin, TX) digitizes the PMT signal with a 29 MHz pixel clock and generates images. Both of the scanning mirrors and the stage are controlled by LabVIEW software (National Instruments), and the mirrors are driven by a data acquisition (DAQ) board (NI PCI-6251, National Instruments).
To maximize signal throughput and maintain sufficient axial sectioning, the size of the detection pinhole was selected to be approximately equal to the projected Airy disk. The intensity distribution as a function of normalized radial optical coordinate, , for a single fluorescent point object in focus is given by29 The first minimum of the lateral response in Eq. (1) occurs at . Using 29 For and , the normalized half-width of the axial point spread function is . Converting to the half-width half maximum in spatial dimensions using
The scanning microscope can be operated in two modes: raster-scanning or stage-scanning. In either mode, the polygon scanner provides the fast axis scan, or line scan, at a scan rate of 8.33 kHz. In raster-scanning mode, the slow axis scan, or frame scan, is provided by the galvanometer scanning mirror, generating FOV images at 8 frames per second. In stage-scanning mode, the galvanometer scanning mirror is positioned in the center of its scan range (center of FOV), and the motorized linear stage translates the sample in the second axis. The image acquisition speed, FOV, and digital image size are limited by the stage speed, stage travel range, and frame grabber memory, respectively. Acquisition of a single 60 megapixel image of FOV takes approximately 10 s. Acquisition of a stack of 60 frames with a FOV and a 10 µm axial step interval between consecutive images over an axial range of 600 µm takes approximately 20 min. The 600 µm axial range was necessary to capture the topography of the sample and to accommodate a minor incline of the translation stage over the 100 mm of travel. The XYZ motorized translation stage has three independently mounted axes; re-positioning the stage may reduce the required axial range and, consequently, increase the three-dimensional image acquisition rate.
To increase FOV and data acquisition speed, lateral resolution is sacrificed by under-sampling with a 1 µm pixel size, which is significantly larger than the 0.375 µm theoretical lateral resolution. The system lateral resolution was measured by capturing an image of a reflective Ronchi grating (Edmund Optics) with . A line profile was plotted across several grating edges. The distance between the 10% and 90% intensity values was recorded for five edges and then averaged. The measured lateral resolution is approximately 1 µm. For our application, imaging tissue and crypt structure in the mouse colon, lateral resolution is less important than the field of view, speed of image acquisition, and file size. We can resolve 2 µm according to the Nyquist Theorem; therefore, the sampling is sufficient to resolve individual cell nuclei, which are approximately 5 to 10 µm in diameter, and crypt lumen, ranging from 40 to 70 µm in diameter in normal mouse colon tissue. To measure axial resolution, a reflective silver mirror was translated through the focal plane. Intensity values were recorded from the PMT and plotted. The measured full width half maximum axial resolution is less than 2 µm. Table 1 summarizes the imaging parameters for the confocal fluorescence microscope system in raster-scanning and stage-scanning modes.
Table 1
List of system and imaging parameters for the confocal fluorescence microscope.
|System/Imaging parameters
|Excitation wavelength
|488 nm
|Detection wavelength
|Lateral resolution
|1 µm
|Axial resolution
|2 µm
|Line scan speed
|Raster-scanning mode
|Field of view
|Frame scan speed
|Stage-scanning mode
|Field of view
|Frame scan speed
Sample Preparation and Imaging
Human colitis can be modeled in healthy rodents by treatment with dextran sodium sulfate (DSS) added to their drinking water.30 An increase in disease duration results in an increased rate of neoplastic development. When used in conjunction with azoxymethane (a colon-specific carcinogen), the mice can develop colon cancer.31
Black C57BL/6 mice were used for this study. The animal protocol was reviewed and approved by the Texas A&M University Institutional Animal Care and Use Committee. To induce chronic inflammation, a mouse was treated with 2.5% DSS (MP Biomedicals) for five days followed by a 17-day recovery period. On day 22, the treatment and recovery periods were repeated. Finally, the mouse was treated with 2% DSS for four days. Termination occurred on day 57.
Following colon resection, the normal and inflamed mouse colons were opened longitudinally along a fatty tissue line. The tissue was rinsed in two phosphate buffered solution (PBS) washes to remove any fecal matter. The colons were stained with of acridine orange (Sigma-Aldrich) for two minutes and then rinsed in PBS for one minute. Each mouse colon was placed flat in a Petri dish with the inside of the colon facing up. A microscope slide was placed on top of the colon to flatten and immobilize the tissue during imaging.
When imaging a mouse colon, the tissue is positioned in the focal plane of the microscope using raster-scanning mode. In order to evaluate tissue features along the length of the colon, extended FOV confocal images are acquired using stage-scanning mode. The long axis of the FOV is specified based on the length of the mouse colon. The topography of a mouse colon varies along its length; therefore it was necessary to acquire vertical stacks of extended confocal images to capture information at different focal planes. The number of images in a stack or the depth of imaging is determined by the topography and the penetration of light into the tissue. The long stacks were used to build a Z-projection image that reconstructs the surface profile of the mouse colon tissue while maintaining high resolution features. For the images presented in this paper, 70 extended confocal images, approximately , of normal mouse colon tissue and 50 images, approximately , of chronic inflamed colon were acquired with a 10 µm step interval between consecutive frames in the axial direction.
Following confocal imaging, tissue samples from proximal, middle, and distal regions of the colon were prepared for histological processing. In contrast to the standard transverse slicing, the tissue was oriented to generate tissue slices parallel to the surface of the tissue to enable a comparison to the en face confocal images. The tissue sections were stained with hematoxylin and eosin (H&E).
Image Analysis
Images stacks were processed into two-dimensional projections and videos using Photoshop (Adobe Systems Inc., San Jose, CA) and ImageJ (National Institutes of Health, http://rsbweb.nih.gov/ij). Each image stack was reduced to a two-dimensional maximum intensity Z-projection image. The maximum intensity projection command in ImageJ selects the maximum pixel value for a single pixel location within a stack of images and generates an image using the maximum values for all pixel locations. Because the colon tissue topography varies significantly within this large field of view and confocal sectioning yields a thin optical slice through the tissue, the Z-projection allows visualization of the colon crypts near the surface along the length of the colon. It was determined that the image quality of Z-projections was improved by using every other image in the stack, resulting in 20 μm axial separation between images in the stack. Figure 2 demonstrates the maximum intensity Z-projection and three dimensional reconstruction for a stack of confocal images. Figures 2(a)–2(d) show four confocal images of a region separated by 20 μm in depth taken from the image stack. Figure 2(e) is a zoomed-in section depicted by the white box in Fig. 2(a) exhibiting bright nuclei surrounding colon crypts. The corresponding maximum intensity Z-projection is shown in Fig. 2(f) to demonstrate the effect of the projection image, and the three dimensional reconstruction is shown in Fig. 2(g) for comparison. Due to tissue absorption and scattering, the maximum imaging depth in colon tissue stained with acridine orange is approximately 60 μm.
Images were cropped to to more easily visualize tissue features along the length of the colons, and regions were selected and cropped to zoom in on the diverse crypt features in the colon tissue. Additionally, the images were resized to correct for non-square pixels. While the vertical pixel size is 1 μm, the horizontal pixel size is 0.78 μm when the stage is scanning at maximum speed. The images were skewed to achieve pixel size. The image contrast was enhanced and normalized for improved print viewing. To better illustrate the size of the extended FOV images and for comparison of crypt features in normal and inflamed colons, the Z-projection images of normal and inflamed tissue were combined in a video file (Video 1). Adobe Premiere Pro CS5 software was used to generate the video.
Figure 3(a) shows of a Z-projection extended FOV image of normal mouse colon. The image is oriented with the proximal end, or ascending colon, to the left and the distal end, or sigmoid colon, to the right. Sample regions of interest from the length of the colon were selected, cropped to , and enlarged to more clearly show cellular and crypt features in the image. These regions are depicted by white rectangles in Fig. 3(a). Figures 3(b) and 3(c) are cropped regions of Fig. 3(a) from the proximal region of the mouse colon. Figure 3(d) is a microscope image of a histology slide prepared from a section of tissue at the proximal end of the colon. In the histological process, the tissue was oriented parallel to the mucosal surface such that the histology image would emulate the en face confocal image, to provide a direct comparison to confocal images. Similarly, confocal and histology images are shown for middle, Figs. 3(e)–3(g), and distal, Figs. 3(h)–3(j), regions of the colon. The confocal images and the histology images are shown on the same scale to enable comparison of crypt features. The extended FOV confocal image [Fig. 3(a)] is . Figures 3(b), 3(c), 3(e), 3(f), 3(h), and 3(i) are .
The crypts shown in the confocal images of normal colon are uniform in size and distribution along the length of the colon, Fig. 3(b), 3(c), 3(e), 3(f), 3(h), and 3(i). The lumen size within the histology images, Fig. 3(d), 3(g), and 3(j), correlate with the confocal images and confirm the homogeneity of the colon. There is not a significant change in lumen size, shape, or distribution along the mouse colon tissue surface.
Figure 4(a) is a section of a Z-projection extended FOV image of chronic inflammation in the mouse colon. The white rectangles indicate the positions of Figs. 4(b) and 4(c) in the proximal region, Figs.4(e) and 4(f) in the middle region, and Fig. 4(h) and 4(i) in the distal region, moving left to right in the image. Figures 4(d), 4(g), and 4(j) are the corresponding en face histology images from the proximal, middle, and distal regions, respectively. The image locations were selected to highlight the diversity of tissue structure along the length of the inflamed colon.
In some areas within the confocal images of inflamed colon, the crypts appear uniform in size and shape, for example in Figs. 4(b), 4(c), and parts of 4(f). While in other locations, such as Figs. 4(e), parts of 4(f), 4(h), and 4(i), the crypts are spaced further apart or exhibit large lumen that are not circular in shape. As compared to the normal mouse colon, the inflamed tissue has a loss of architecture with non-uniform crypts that are not evenly distributed across the tissue surface. The histology images of the mouse colon tissue with chronic inflammation show heterogeneity of the tissue as the lumen size varies from one location to another, Figs. 4(d), 4(g), and 4(j).
We have constructed a confocal microscope combining beam scanning and rapid stage scanning at to rapidly acquire-high aspect ratio images. We demonstrate this technique on excised mouse colon to enable evaluation of tissue features along the length of the colon. Extended FOV images of normal mouse colon show the homogeneous distribution of colon crypts along the entire length of the colon. In contrast, the extended FOV images of inflamed tissue show a wide range of crypt size, shape, and distribution. Some regions appear quite normal; whereas, other regions show extremely distorted crypt structure. For example, if we compare the confocal image with the most severe crypt distortion in the inflamed colon [Fig. 4(e)] to an image taken near the same location in the normal colon [Fig. 3(f)], the average area and standard deviation of the crypts defined by the bright ring of colonocyte nuclei is for the inflamed tissue and for the normal tissue. Furthermore, the average eccentricity and standard deviation decreases from to from inflamed to normal tissue, where a circle has an eccentricity of 0 and a line has an eccentricity of 1. Rapid confocal imaging and image processing could provide a quantitative map of crypt area and eccentricity to measure severity of tissue distortion with inflammation. It may also be used for fast identification of focal changes such as aberrant crypt foci, which are small groups of crypts with altered size and shape thought to be precursor lesions to colon cancer.32
Our current system configuration is intended for pre-clinical studies of excised mouse colon tissue. This technique can be further expanded to other applications by stitching multiple extended FOV images together to create a large-area image.26 Potential clinical applications include dermatological33 and gastroesophageal27 studies. Combined beam and stage scanning could also increase the large field of view image acquisition speed for other point scanning microscopy techniques, such as non-linear microscopy. In comparison to other systems, the length of our images and speed of acquisition are significantly higher. The image acquisition speed is currently limited by the maximum speed of the translation stage. Use of a faster stage would further increase image acquisition speed to the point that the polygon scanning mirror, our fast axis line scanner, would be the limiting factor. The acquisition of image stacks is currently limited by data transfer and saving, and not limited by the translation stage.
We have presented confocal images that show potential for classifying an inflammatory region within the colon based on crypt lumen size, shape, and distribution. The homogeneity of normal mouse colon tissue compared to the heterogeneous nature of tissue exhibiting chronic inflammation is clearly evident within regions of the colon. Some regions within the inflamed colon, Figs. 4(b) and 4(c) for example, may be considered "normal;" therefore, a rapid stage-scanning image technique to evaluate the entire organ to identify regions of interest may be valuable. We are able to acquire data along the entire length of the mouse colon in a relatively short period of time.


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Toddler Jewelry - 3 Piece Butterfly Jewelry Set for Little Girls
Toddler Jewelry - 3 Piece Butterfly Jewelry Set for Little Girls
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Glennies pool to reopen
One of Edinburgh Leisure's six Victorian pools, Glenogle in Stockbridge, is to reopen on Monday, 11 September, having undergone a major £200k refurbishment to replace the poolside tiling to maintain the longevity of the pool and improve the customer experience.
Sauna and steam room facilities are currently not available but new facilities will open within the next month.
Wendy Avinou, Manager at Glenogle, said: "Whilst the work has taken longer than expected to complete, we are grateful to our Edinburgh Leisure customers for their patience whilst the refurbishment took place and hope they have enjoyed the opportunity to try out other Edinburgh Leisure facilities across the city in the meantime.
"We are looking forward to welcoming old and new customers back, including the casual swimmers and indeed those looking for coaching options. If you are interested in finding out more about our adult or children's coaching options, pay us a visit or look online."
With over 20 years' experience in helping the people of Edinburgh learn to swim, our swim teams are led by highly qualified Level 2 teachers who are continually up-skilled, developed and monitored by a team of professionals. Edinburgh Leisure offer classes for all ages from birth to adults, including lessons for children with additional support needs in a choice of centres.
In the heart of the city centre, between Cannonmills and Stockbridge, Glenogle Swim Centre is something of a rare breed, a hark back to Victorian baths but with a modern twist. 'Glennies' boasts a restored Victorian swimming pool and a gym with state of the art equipment and free-weights room and fitness studio.
In addition to the recent pool refurbishment, Glenogle gym and studio underwent a £55k facelift in the winter of 2015, with new equipment being installed and the studio given a refresh.
Further information is available on www.edinburghleisure.co.uk. Follow Edinburgh Leisure on Facebook (EdinburghLeisure) and Twitter (@Ed_Leisure).


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I've been dying to try this recipe since I first saw it! It just has too much goodness packed into it not to try out – did you say – homemade caramel – apples, pecans, cheesecake and fresh whipped cream? Ummm – yes please! I also wanted to use my new pie dish – so I opted to make this in that instead of a cheesecake pan. I think it worked out great.
I was a little nervous about the crust – since I used gluten-free graham crackers (so my Aunt with celiac could eat it). But you would never know the difference – they tasted exactly the same as regular ones (although they did cost a small fortune for graham crackers!).
After the graham cracker crust is baked – you layer in some caramel and then chopped pecans….
Then you layer in some cooked apple slices…..
Next is a layer or cheesecake batter and once baked – topped with fresh whipped cream and garnished with pecans and caramel.
Are you drooling yet? If so - go make this dessert!
For the caramel:
- 1 cup sugar
- 3 Tbsp. water
- 1 Tbsp. light corn syrup
- 3/4 cup heavy cream
- 1 Tbsp. unsalted butter
For the crust:
- 1 1/2 cups graham cracker crumbs
- 3 Tbsp. sugar
- 1/2 tsp. cinnamon
- 5 1/3 Tbsp. unsalted butter, melted
- 1/2 – 3/4 cup caramel
- 1 cup chopped pecans
For the apple filling:
- 5 Tbsp. unsalted butter
- 1/2 cup light brown sugar
- 1/4 tsp. salt
- 1 tsp. cinnamon
- 4 Granny Smith apples, peeled, cored and thinly sliced
For the cheesecake:
- 8 oz. cream cheese
- 1/4 cup sugar
- 1 tsp. vanilla extract
- 1 large egg
- 1 Tbsp. freshly squeezed lemon juice
For the topping:
- 3/4 cup heavy cream
- 3 Tbsp. confectioners' sugar
- 1/4 cup caramel
- Chopped pecans
1. To make the caramel: Put the sugar, water and corn syrup in a medium heavy-bottomed saucepan and stir to combine. Heat over medium-high heat, without stirring, until the caramel turns deep amber. As the sugar is caramelizing wipe down any splatters on the sides of the pan with a pastry brush dipped in cold water. Lower the heat and and add the cream and butter. Once done bubbling – stir until smooth and remove the pan from the heat. Cool and refrigerate until ready to use (can be made in advance).
2. To make the crust: Preheat the oven to 375° F.
3. In a mixing bowl, combine the graham cracker crumbs, sugar, cinnamon and melted butter and combine until all the crumbs are moistened and the ingredients are evenly mixed.
4. Transfer the mixture to a 9 inch springform pan or deep dish pie plate and press the crumbs in an even layer over the pan bottom and up the sides of the pan. Bake for 6-8 minutes, until golden in color. Let cool for about 10 minutes.
5. Pour a layer of caramel into the bottom of the crust and sprinkle evenly with the chopped pecans.
6. To make the apple filling: Melt the butter in a large skillet over medium heat. Mix in the brown sugar, salt and cinnamon and cook for 1 minute, until bubbling. Mix in the apple slices and toss well to coat. Cook over medium to medium-high heat until tender and most of the liquid has been reduced, about 15-20 minutes. Let cool for a few minutes and pour into the prepared pie shell. Set aside.
7. Reduce the heat of the oven to 350° F.
8. To make the cheesecake layer: Combine the cream cheese and sugar in the bowl of an electric mixer and beat on medium speed until smooth, about 1 minute.
9. Mix in the vanilla, egg and lemon juice until fully incorporated and smooth, 1-2 minutes.
10. Spread the cheesecake filling into an even layer over the top of the cooked apples in the crust. Bake until a knife inserted in the center comes out clean, about 30 minutes.
11. Remove from the oven, transfer to a wire rack and let cool to room temperature. Refrigerate for at least 4 hours.
12. In the bowl of an electric mixer fitted with the whisk attachment, beat the heavy cream and confectioners' sugar on medium-high speed until stiff peaks form. Spread gently over the top of the chilled cheesecake layer. Top with dollops of caramel sauce and swirl with a knife to create a marbled effect. Sprinkle with a handful of chopped pecans.
Source: Annie's Eats, caramel from Baking from my Home to Yours by Dorie Greenspan


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I really don't know how to break this to players of GAIA volcano (which seemed to only be a few) but unfortunately our Map messed up and our backup system failed us.
I do not have a copy of the map from Friday and I have been away all weekend and didn't see a problem.
I have sorted the backup system so this won't happen again but unfortunately anything users had on GAIA have been lost.
IF you have lost a lot I will give resources back to you and help you get dinos back. Please contact me on private message on JR to tell me honestly what you have lost.
I am very sorry this issue occurred, it will never happen again.


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Let's face it, winter skin is not the prettiest skin – the harsh temperatures and whipping winds call for some serious damage-control moisturizers.
My naturally dry skin craves intense moisture during the colder months, and I often bounce between beauty products until I find something that temporarily satiates me. After hearing from my mom and a few friends how happy they were with Bio-Oil products, I decided to give it a try.
Application and usage is pretty cut-and-dry: massage the oil directly to your skin about twice a day for a minimum of three months. I haven't hit the 3-month mark yet myself, but I have definitely started seeing a change in my skin: my legs are smoother, and the winter itch has all but disappeared. I'm also loving the light cinnamon-y scent…it makes application a totally enjoyable experience.
Bio-Oil goes beyond moisturizing, too. It's known to decrease the appearance of scars and stretch marks with repeated use. If you're in the market for a new moisturizer, I highly recommend swapping out your cocoa butter regimen for a little Bio-Oil goodness.
Have you tried Bio-Oil? We'd love to hear about your experience in the comments!
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Amanda is a NYC-based social media professional by day and a beauty-obsessed blogger by night. When not managing communities at VaynerMedia, Amanda can be found Twittering away on her iPhone or rooting through Sephora in search of that just-perfect shade of red lipstick.


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Bill Books
Perfect for invoices or using as receipt books
- 50 sheets per pad, convenient 4.2 x 5.4 in size
- Customise with your logo and address
- Upload your own bill book design
- Magnetic option for fridges or desks
- 90 gsm acid-free paper
- Can also be used as – Notepads
- We don't provide carbon copy OR pink / yellow copies OR serial numbers
Sorry, we don't offer this design in
1 units minimum
Price ₹ 100.00 ...
Invoices and receipt books for your daily business transactions.
Customised bill books or receipt books can be used for your organisation's daily business needs. Bill books are widely used to issue receipts or bills to your customers and clients. These bill books will carry only the original copy and not duplicate or triplicate carbon copies.
- TYPE: Bill Books
- SIZE: 4.2 x 5.4 in (107 x 139 mm)
- PAPER: 90 gsm acid-free smooth finish paper
- SHEETS: 50 sheets per pad
- BACKING: Magnetic option available


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Chandler Warner, Gertrude. The Boxcar Children: The Animal Shelter Mystery. O. 1991.
This book is #22 in a series. When a stray calico cat appears, the children look for the founder of the town's other animal shelter.
TAGS: Boxcar children, mystery, stray animals, caring, pets, John F. Kennedy, O, Level O, Oscar