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Serotonin Reuptake Inhibitors/Linezolid Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Both of these medicines can increase the level of serotonin in your body.
What might happen:
High serotonin levels may cause changes in body temperature, blood pressure and behavior, leading to a medical condition called Serotonin Syndrome. Serotonin Syndrome may be life threatening.
What you should do about this interaction:
Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together.If you experience muscle twitching, tremors, shivering or stiffness, fever, heavy sweating, heart palpitations, restlessness, confusion, agitation, trouble with coordination, or severe diarrhea contact your doctor right away.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.USFood and Drug Administration. FDA Drug Safety Communication: Serious CNS reactions possible when linezolid (Zyvox) is given to patients taking certain psychiatric medications. available at: https://wayback.archive-it.org/7993/20170722185915/https://www.fda.gov/Drug s/DrugSafety/ucm265305.htm July 26, 2011.
- 2.Prozac (fluoxetine hydrochloride) US prescribing information. Eli Lilly and Company October, 2014.
- 3.Zoloft (sertraline) US prescribing information. Pfizer Inc. December, 2017.
- 4.Effexor (venlafaxine hydrochloride) US prescribing information. Wyeth Pharmaceuticals December, 2012.
- 5.Luvox (fluvoxamine maleate) US prescribing information. Jazz Pharmaceuticals, Inc. January, 2017.
- 6.Serzone (nefazodone hydrochloride) US prescribing information. Bristol-Myers Squibb Company January, 2005.
- 7.Pexeva (paroxetine mesylate) US prescribing information. Noven Therapeutics, LLC December, 2012.
- 8.Bernard L, Stern R, Lew D, Hoffmeyer P. Serotonin syndrome after concomitant treatment with linezolid and citalopram. Clin Infect Dis 2003 May 1;36(9):1197.
- 9.Wigen CL, Goetz MB. Serotonin syndrome and linezolid. Clin Infect Dis 2002 Jun 15;34(12):1651-2.
- 10.Hachem RY, Hicks K, Huen A, Raad I. Myelosuppression and serotonin syndrome associated with concurrent use of linezolid and selective serotonin reuptake inhibitors in bone marrow transplant recipients. Clin Infect Dis 2003 Jul 1;37(1):e8-11.
- 11.Lexapro (escitalopram oxalate) US prescribing information. Forest Pharmaceuticals Inc. January, 2019.
- 12.Celexa (citalopram hydrobromide) US prescribing information. Forest Laboratories Inc. January, 2019.
- 13.Cymbalta (duloxetine hydrochloride) US prescribing information. Eli Lilly and Company April, 2020.
- 14.Tahir N. Serotonin syndrome as a consequence of drug-resistant infections: an interaction between linezolid and citalopram. J Am Med Dir Assoc 2004 Mar-Apr;5(2):111-3.
- 15.Bergeron L, Boule M, Perreault S. Serotonin toxicity associated with concomitant use of linezolid. Ann Pharmacother 2005 May;39(5):956-61.
- 16.Thomas CR, Rosenberg M, Blythe V, Meyer WJ 3rd. Serotonin syndrome and linezolid. J Am Acad Child Adolesc Psychiatry 2004 Jul;43(7):790.
- 17.Morales N, Vermette H. Serotonin syndrome associated with linezolid treatment after discontinuation of fluoxetine. Psychosomatics 2005 May-Jun;46(3):274-5.
- 18.Lavery S, Ravi H, McDaniel WW, Pushkin YR. Linezolid and serotonin syndrome. Psychosomatics 2001 Sep-Oct;42(5):432-4.
- 19.Jones SL, Athan E, O'Brien D. Serotonin syndrome due to co-administration of linezolid and venlafaxine. J Antimicrob Chemother 2004 Jul; 54(1):289-90.
- 20.Clark DB, Andrus MR, Byrd DC. Drug interactions between linezolid and selective serotonin reuptake inhibitors: case report involving sertraline and review of the literature. Pharmacotherapy 2006 Feb;26(2):269-76.
- 21.Boyer EW, Shannon M. The serotonin syndrome. N Engl J Med 2005 Mar 17; 352(11):1112-20.
- 22.Priligy (dapoxetine hydrochloride) Australian prescribing information. Ortho-McNeil Pharmaceutical March 19, 2013.
- 23.Trintellix (vortioxetine) US prescribing information. Takeda Pharmaceuticals America, Inc. July, 2019.
Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.


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Triple Action Plasmacluster Air Purifier with Humidifying Function (254 sq. ft.)
Browse all deals at JCPenney
See more in Air Purifier Accessories
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* This offer may contain time-sensitive information and offers. Please check with JCPenney to confirm actual price & availability.
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619 N Perkins Rd
Stillwater, OK 74075

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- Did you mean
- wooster ag facilities consisted research farm
Search results
OSU Agricultural Lender Seminar Virtual for 2020
training to over 150 lenders annually. "To provide a national view of the U.S. Ag and Financial Conditions ... a senior business economist in the Economic Research Department. He conducts research on the agricultural ... and Farm Policy; Barry Ward, OSU Extension, Enterprise Budgets and Returns per Acre; Peggy Hall, OSU ...
Devin Peterson named a CFAES Dean's Chair
opportunities within food sciences and health initiatives and partnerships at the CFAES Wooster campus. Peterson ... science; is faculty director of the Foods for Health Discovery Theme; is director of the Flavor Research ... Resource, an Ohio State Comprehensive Cancer Center core facility. Read more. Photo: Devin Peterson, right, ...
University/industry partnership takes field scouting to the next level
Caren Ag Center farm manager Nate Douridas and his team have been conducting various research projects ... he added. Like any research project in the ag industry, the effectiveness of the scouting program ... Extension Farm Science Review Research Business and Economics Crops CFAES News Team firstname.lastname@example.com ...
Go outdoors, but watch for ticks
Environmental Sciences (CFAES) and Veterinary Medicine at The Ohio State University. Pesapane researches ticks ... ticks, u.osu.edu/bite/. If you'd like to help with research on Ohio ticks, please send ticks you find ... Nutrition Home Family and Youth Lawn and Garden Livestock Natural Resources and Environment Wooster area ...
CFAES scientists part of effort to study COVID-19 in first responders
CFAES scientists Linda Saif and Anastasia Vlasova, both of the Food Animal Health Research ... officer for the Wexner Medical Center and vice dean for research for the College of Medicine. Read the ...
Learning together safely: virtual Farm Science Review a success
CFAES' virtual Farm Science Review was a success, manager Nick Zachrich reported. Initial ...
CFAP 2 Program & Fall Weed Control
process can now be completed online. Applications will be processed by the Farm Service Agency. Fall Weed ... provides research and related educational programs to clientele on a nondiscriminatory basis. For more ...
Farm Science Review draws virtual visitors
Matt Marx and Alayna DeMartini Neither too hot nor rainy, this year's virtual Farm Science Review ... the farm, and operating new technology to better manage their crops. This was the 58th annual Farm ... live exhibitions of the latest agricultural technology, learned helpful farming techniques, and heard ...
Money Concepts for Kids
These are based on knowledge and familiarity with concepts like research and analysis. Teenagers often ... 330-264-8722. CFAES provides research and related educational programs to clientele on a nondiscriminatory ...
Learn how to become a Buckeye and CFAES student during Farm Science Review Online
University's Columbus or Wooster campus, you'll want to catch the virtual sessions offered Sept. 22–24 as part ... of Farm Science Review. For the first time in its almost 60-year history, FSR will not be held in ... and an overview of the Wooster campus. Because the college experience is about more than just spending ...


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University of Massachusetts Amherst. University as a Whole
Established under the Morrill Land Grant Act of 1863, the Massachusetts Agricultural College began with four faculty members and 56 students distributed among four wooden buildings and acres of farms, orchards, and fields. In keeping with the progressive educational principles of its early years, the College offered advanced instruction in the eminently practical pursuit of agriculture, while its fellow land grant college, MIT, covered the mechanical arts. Although "Mass Aggie's" fortunes waxed and waned, it grew to become Massachusetts State College in 1931, and the University of Massachusetts in 1947.
Among the official publications of the University in Record Group 1 are institutional histories, annual reports, special reports, minutes, directories, catalogs, newsclippings, press releases, and memorabilia.


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Reminders of Germany's earliest industrial heritage: documenting around 1,000 years of mining history, the Mines of Rammelsberg on the outskirts of the beautiful old town of Goslar were once the largest interconnected repositories of copper, lead and zinc ore in the world. Energy for the mine was supplied by the Upper Harz water management system, the world's foremost pre-industrial water management system for the mining industry.
Producing almost 30 million tonnes of ore, the Rammelsberg mines shaped the history and development of the town of Goslar in the Harz region; they also led Emperor Heinrich II to establish an imperial palace here. The first imperial assembly in Goslar took place in 1009 and the town remained a royal seat for German kings and emperors until 1253. In 1988, after more than 1,000 years of virtually non-stop mining, the ore extraction was stopped. Today, it lives on in a museum of impressive scale and authenticity. Not quite so big, but just as authentic is Goslar's old town, whose enchanting skyline is dominated by the mighty Romanesque palace and the towers of no fewer than 47 churches and chapels. The preserved townscape is dominated by elegant guildhalls reflecting the wealth of the citizens, by the historical town hall and by timber-framed houses with ornamental carvings. In 2010 the World Heritage site was expanded to include Walkenried Abbey, the historical Grube Samson mine in St. Andreasberg and the Upper Harz water management system. The latter, considered a masterpiece of early mining and engineering artistry, consists of 107 historical ponds, 310 kilometres of ditches and 31 kilometres of waterways. It is one of the largest pre-industrial power supply facilities in the world. This part of the World Heritage site can be explored on foot along a network of waterside trails, which highlight not only the technological innovations but also the beauty of the landscape.
Old Town of Goslar
Sightseeing tours by Lilliput train or horse-drawn carriage
Guided tours: 'A thousand steps through the old town' daily at 10am; 'Afternoon walk' from April to October and also in December, Monday to Saturday at 1.30pm
Guided tours in foreign languages available in Czech, Danish, Dutch, English, French, Japanese, Norwegian, Polish and Russian; dates/times by arrangement
Guided tours for the deaf (sign language), partially sighted and blind.
Further information: www.goslar.de
Mines of Rammelsberg
Museum and visitor centre at the Mines of Rammelsberg in Goslar, 9am to 6pm daily
Further information: www.rammelsberg.de
Upper Harz Water Management System
Guided tours of the historical water management system at the Upper Harz Mining Museum in Clausthal-Zellerfeld
Further information: www.oberharzerbergwerksmuseum.de
Mines of Rammelsberg, Historic Town of Goslar and Upper Harz Water Management System is part of the '' UNESCO route. Other stops on the route are:
UNESCO World Heritage sites:
Other towns and cities worth seeing:
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Küçültme: +
Daha fazla yardım için aşağıdaki simgeye tıklayarak sağlayıcınızla bağlantı kurun:


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The Asia-Pacific region is expected to become the largest high-net-worth wealth market by 2015, and possibly as early as 2014, according to the 2013 Asia-Pacific Wealth Report, published by CapGemini and RBC Wealth Management.
The region's annualized growth rate from 2012 to 2015 will be 9.8%, the report said, compared with 5.3% for the rest of the world. This puts Asia-Pacific's wealth on track to reach $15.9 trillion by 2015.
Since 2007, Asia Pacific's HNW population has surged by 31% and its wealth by 27%, well ahead of 14% and 9% increases, respectively, in the rest of the world.
Even so, strong HNW population growth in 2012 allowed North America, with 3.73 million wealthy people, to regain the top spot from Asia-Pacific, with 3.68 million, after falling to No. 2 in 2011.
The report defined HNW individuals as those having investable assets of $1 million or more, excluding primary residence, collectibles, consumables and consumer durables.
Most major Asia-Pacific markets grew by double digits in 2012, while other regions experienced mixed growth rates. Japan, where the region's HNW population and wealth have long been concentrated, grew more moderately.
The changes in HNW population and wealth between 2011 and 2012:
- Hong Kong: population 35.7%, wealth 37.2%
- India: population 22.2%, wealth 23.4%
- Indonesia: population 16.8%, wealth 17.9%
- Australia: population 15.1%, wealth 15.5%
- China: population 14.3%, wealth 15.6%
- Thailand: population 12.7%, wealth 19.3%
- South Korea: population 10.9%%, wealth 11.8%%
- Singapore: population 10.3%, wealth 11.5%
- Taiwan: population 7%, wealth 7%
- Japan: population 4.4%, wealth 5.2%
- Other markets: population 14%, wealth 15.3%
Check out Tax-Weary U.S. Millionaires Move to Cayman Islands, Hong Kong for Relief on ThinkAdvisor.


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Anti- is thrilled to announce the signing of Saintseneca, a young band from Columbus, Ohio led by singer-songwriter and multi instrumentalist Zac Little. The group utilizes a wide range of instrumentation (violin, mandolin, dulcimer, Turkish Baglama, floor percussion) with the more contemporary elements such as synthesizers and electric guitars to create a unique merging of rustic and modern. Folk and country motifs converge seamlessly with soaring vocals and a vibrant post-punk energy.
While the group formed in Columbus Ohio, a majority of Saintseneca's members, including songwriter Little, hail from the rural hills of Appalachia. It is a landscape that has infused the group's expansive and evocative music with a deep sense of introspection. "I was raised on farms in Appalachia, "Little explains, "And I think that my perspective on music was shaped by where I grew up. Being so isolated played a huge role in my music and in the subjects I write about."
The band's poetic lyricism and folk instrumentation is powerfully enhanced by elements of pop, post-punk and psychedelia. It is a memorable and moving sound which originally evolved playing alongside electrified punk bands at DIY house shows. "Playing those shows made us want to draw the most sound and volume from the instruments we were using," Little explains.
Check out Saintseneca on Live From Bad Racket, a video series featuring artists performing at the Cleveland based recording studio: http://vimeo.com/55768714
Saintseneca will be performing a series of North American dates.
Live Dates: 6/17 Cleveland, OH @ Beachland Tavern 6/20 Philadelphia, PA @ Moonbase Nix 6/21 Boston, MA @ Lily's Pad 6/22 New Haven, CT @ The Space 6/23 Brooklyn, NY @ Hillstock Music Fest 6/24 Brooklyn, NY @ Death By Audio 6/25 Doylestown, PA @ Siren Records 6/26 Willimantic, CT @ Shitty Present HQ 6/27 Washington, DC @ The Dollhouse 6/28 Norfolk, VA @ The Iguana 6/29 Pittsburgh, PA @ Mr. Roboto Project


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Winterberg is the ideal place to enjoy an active and healthy lifestyle. The region offers unspoilt nature, a therapeutic climate and any number of outdoor activities.
Top winter sport athletes have shot to fame in this town of international sporting renown but spa visitors can enjoy a healthy and relaxing break here too.
Natural attractions
In addition to a cleverly designed network of year-round walking trails that open up the beautiful natural surroundings, there are also plenty of cycle routes, which cater for a range of abilities, enabling everyone to take full advantage of the therapeutic climate. Winterberg is a dedicated winter sports resort offering a wide range of activities.
Climatic therapy
For visitors wishing to focus on their health, the climate is a rich source of effective therapy options that harness the excellent quality of the air. The many ways of benefiting from the climate include 'rest cures', exposure to the fresh air, sunbathing (heliotherapy) and 'terrain cures' (Nordic walking). Whatever their preference, holidaymakers can rest assured that the declared aim of all local climatic therapy is to improve well-being and health through exposure to climatic and weather-related conditions in doses controlled and tailored to individual needs. The effectiveness of climatic therapy is not confined to curative medicine; it also has preventative benefits such as strengthening the immune system and boosting circulation.
An additional attraction is the holiday region around Winterberg: the Sauerland offers a lively arts scene and plenty of picturesque towns and villages to discover and explore.
To nyttige hurtigtaster for å zoome i nettleseren:
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Mer hjelp får du fra nettleserleverandøren ved å klikke på ikonet:


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Courts Bracing for Cut of About $300 Million From Judiciary Budget, Judge Marks Says in Memo
Global Briefing
A weekly, curated selection of our international content from around the globe, across the business of law, in-house, regulatory, technology and more, with expert insights from our senior editors.
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Corporate Counsel
Bacardi Hires Beverage Industry Veteran Todd Grice as Next General Counsel
Grice joins Bacardi at a challenging time for the spirits industry as many bars and restaurants have been shuttered amid the novel coronavirus COVID-19 pandemic.
Corporate Counsel
Legal Departments Should Play Leading Role in CCPA, GDPR Data Subject Access Requests
"What if the consumer says 'Delete all of this?'" Bill Piwonka, chief marketing officer of Exterro, said. "That's easy enough until you start thinking about whether some of that data is under a regulatory mandate to be held for three years or if that data is being used in a lawsuit and is under legal hold."
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Regular price
$ 6.50
jotter: 3.50 x 5.50 x 0.25
set of two coordinating eco notebooks, 40 pages each.
jotter cover: gift wrap letterpressed with word "notes". interior pages: blank. 100% post-consumer recycled, FSC® certified paper.
positioning of illustration varies from jotter to jotter.
made with love in upstate New York.
packaged in a cello bag.


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Wedbush Securities said Monday that it recruited a financial advisor who was formerly with Raymond James (RJF) and Morgan Keegan.
Michael Menefee will serve clients in the greater Dallas-Fort Worth area as a vice president of investments with Wedbush, which has about 400 advisors and 100 offices nationwide.
"Michael's proven track record and dedication to superior client service are two qualities we look for in all of our advisors," said Wesley Long, executive vice president and head of private-client services for Wedbush. "We are pleased to welcome him to the firm as we continue to grow our team of Wedbush financial advisors."
Menefee has been in the financial-services industry for more than 12 years.
Before this work, he served in the U.S. Marine Corps and retired as a lieutenant colonel. In addition, he was decorated for his intelligence efforts, which included a tour with the Defense Intelligence Agency and work as a senior warning intelligence officer on the Joints Chiefs of Staff at the Pentagon.
Wedbush does not share the level of its advisors' fees & commission or assets.
Stratos Wealth
In other recruiting news, independent RIA Stratos Wealth Partners, affiliated with LPL Financial (LPLA), said Tuesday it recruited five advisors from Wells Fargo Advisors (WFC), Edward Jones and other firms with a total of $470 million in assets in three major markets.
The RIA also says it opened offices in New Orleans and Conway, Ark., while expanding in San Diego.
The advisors that joined are:
- Donnie Dietz (formerly of Edward Jones) – Conway, Ark.;
- Philip Garrett Jr. (formerly of Prudential) – New Orleans;
- James Pierik (longtime LPL Financial advisor), Michael Mays (formerly of Wells Fargo Advisors) and Thomas Strohl (Wells Fargo Advisors) – San Diego.
Stratos Wealth Partners now has more than 140 advisors in offices in 15 states. It also has $6.2 billion in assets under management, up about 25% from $5 billion at the end of 2012.
Find out where Stratos placed in our Top 10 Wealth Manager Logos Poll and read the story behind its logo in 10 Best Wealth Manager Logos: Advisors Behind the Winners on AdvisorOne.


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Auto Body Toolmart has been a leading supplier of automotive tools for over 30 years. We carry a complete line of automotive tools, body shop supplies, paint booths, frame machines automotive paint & more to meet the needs of any workshop or garage.Our large supply of automotive repair products for Auto Body & General Automotive repair includes some of the highest quality spray guns, air tools, and air compressors from companies like SATA, DeVilbiss, Ingersoll Rand, 3M, Dupli-Color, Sherwin-Williams, Chicago Pneumatic, and many more. We even have a category of products and tools that are Made in the USA and are some of the best in the business. We carry all the tools, products, and materials to achieve a professional level result whether you are a 10-bay shop or a home restorer. We want our customers and their projects to be the best they can be and all that we sell is geared towards that quality of work. Our in house brand called Champ Products which specializes in auto body and frame straightening equipment is the first of its kind made in the U.S.A. and is far superior to foreign brands.
Founded in 1981 with a complete post-based system for uni-body repair, we have expanded into pulling clamps, chains, body dollies, portable paint stations, automotive rotisseries, equipment carts and much more. If your shop needs a durable, reliable, and well made frame and body straightening system look at Champ!Shop with confidence. We don't sell refurbished or factory seconds. All of our products are new and come with full manufacturer's warranties (except for items in our Scratch & Dent section). If you don't see what you're looking for give us a call, one of our trained and friendly staff can help you order and find any product or tool you are looking for. We can even assist you in larger order like buying a down draft paint spray booth with one of our easy payment plans. No matter the situation, the need, or the budget you can count on Auto Body Toolmart to help you with all your auto body and workshop needs!
By using this website, you agree to our use of cookies to analyze website traffic and improve your experience on our website. Learn More


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Philanthropists around the world want to alleviate global poverty, and according to a new study, the most effective approach may entail coordination of efforts.
Forbes Insight, supported by Credit Suisse, surveyed 317 individuals with investable assets of $1 million or more, exploring the question of how a philanthropist can best help mitigate global poverty.
Seventy-three percent of philanthropists said they wanted to see pattern changes at the highest levels, as they seek to affect international or government policies at the onset of their giving.
A problem as huge as global poverty can be addressed only by systemic change rather that specific projects, they said. Fifty-seven percent agreed that wealth creation, understood as economic growth that benefits most of society, was an effective means to alleviate or eradicate poverty.
Nearly half of survey respondents agreed that too many organizations within the non-profit sector overlapped.
Although many individual donors wanted to make their own imprint, the most effective approach for a philanthropist tackling global poverty may be to join forces with other experienced philanthropists or organizations or to seed the initiatives of others.
The research showed that philanthropy could be viewed as a portfolio, with some assets devoted to global initiatives—which entail systemic change and have longer turnarounds—and some to local initiatives, which can have a necessary, immediate effect.
Among the respondents, 42% focused on targeted and local giving, 29% on global giving and the remaining 29% on either or both. Global giving was more prevalent among 40% of the wealthiest respondents, those with investable assets of more than $50 million.
Twenty-six percent of respondents defined success as focus on long-term impact, while 23% saw it as alleviating physical suffering or meeting immediate needs.
Women's health issues continue to gain in importance, with family planning and contraception expected to become a top priority in the next five years, named by 33% of respondents.
Fifteen percent of those surveyed said they had personally made their biggest contribution to this area.
Check out these related stories on ThinkAdvisor:


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WASHINGTON, D.C. (AP) – Jamil Wilson scored 16 points, Vander Blue and Davante Gardner had 14 apiece, and Marquette advanced to the Elite Eight for the first time since 2003 with a 71-61 win over Miami on Thursday night.
The third-seeded Golden Eagles took a double-digit lead in the first half and never relinquished it, quite the contrast from their nail-biters earlier in the NCAA tournament. They shot 54 percent from the field and held the Hurricanes to 35 percent. Miami missed 18 of 26 3-point attempts.
Marquette (26-8) will face either top-seeded Indiana or No. 4 Syracuse in the East Regional final on Saturday.
Shane Larkin scored 14 points for the second-seeded Hurricanes (29-7), who matched the best NCAA run in school history.
(© 2013 The Associated Press. All Rights Reserved. This material may not be published, broadcast, rewritten, or redistributed.)


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Product Details
- 18-karat gold
- Band, 6mm
Style Number: R25152M88
Fit & Care
Metal: Use the provided polishing cloth to gently wipe this item clean, then remove any remaining tarnish with mild diluted soap. Rinse with warm water and dry the design thoroughly before storing in the provided jewelry pouch. Please note: styles featuring meteorite should not be exposed to water.


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First a little info on Bee Pollen and Nutritional Yeast:
Bee Pollen: *
Bee pollen contains vitamins, minerals, carbohydrates, lipids, and protein and the Chinese have used Bee Pollen for centuries to assist with increasing energy and libido, fighting acne, aiding in indigestion, assisting depression and helping to improve blood pressure.
*Bee pollen is not safe for pregnant women. A woman should also avoid using bee pollen if she is breastfeeding.
Nutritional Yeast:
Nutritional Yeast is FULL of nutrients and is a great addition to a healthy lifestyle, especially for those who are vegan or vegetarian. It is one of the few non-animal sources of B-12, is rich in folic acid and many other nutrients and amino acids. This is not your typical yeast and is free of the Candida Albicans strain, making it safe for those concerned with candida.
Benefits of Purple Basil: http://chefsecrets.info/vegetarian/permalink.php?article=Benefits-of-Green-%26-Purple-Basil-Pesto%2C-Basil-Leaves%2C-Basil-Oil.txt
Now for the Recipe:
- 1 1/2 cups of Fresh Cut Herbs: I used Purple Basil, Green Basil, a bit of mint and Onion Chives cut the leaves and wash thoroughly.
- Fresh Garlic as many cloves as you like
- tablespoon Nutritional Yeast
- tablespoon or less or bee pollen
- salt (I use pink Himalayan salt, but you can use what you like)
- pepper
- squeeze of lemon
In a blender or food processor, add your herbs…
add fresh garlic
then, bee pollen
nutritional yeast…
about 5 tablespoons of olive oil
add a squeeze of lemon, salt and pepper to taste
ENJOY on pasta, bread, by itself or in a salad


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Discussion in 'StarCraft I & II' started by JimBob, Aug 14, 2010.
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text:
Whitepages PRO (the enterprise division of Whitepages) has launched a self-service developer portal opening access to new APIs. For those that don't know, Whitepages is a provider of contact information for people and businesses. It also develops mobile apps and business services that make use of its contact data.
PRO's data platform provides access to the "largest database of people and businesses" in North America.
Through the Graph APIs, developers can "enrich their applications" (Whitepages term, not ours) to include identity verification and validation elements, including those centered on names, addresses, phone numbers, businesses, and communications. Developers can now sign up at the new portal to access and integrate the data now.
The new Graph APIs provide access to the Whitepages PRO Contact Graph, a data infrastructure designed to connect people, addresses, and various cell and landline phone numbers.
Typical use cases of the Whitepages PRO Contact Graph include validating user identities, eliminating fraudulent information, and enriching legitimate leads.
Whitepages PRO Graph APIs available via the Developer Center include Person API: returns a dataset about the person behind a name, including related phone numbers, present and historical addresses, and age demographics; Phone API: returns data on any phone number, including the person, location, and address associated with the number, carrier, status on the Do Not Call list, SPAM score, etc.
Kushal Shah, API product manager, Whitepages PRO, explains that the Whitepages PRO Graph APIs use REST/JSON protocols and formats to enable easy integration with other applications to enable lightweight and fast development as well as enterprise-class security and reliability.
"Once the API key is opened, the data is available in seconds, and can be fused into virtually any application that needs identity data for consumer or business applications. For example, Whitepages PRO's APIs have been integrated with Twilio, giving users access to the identity data to decrease call handle times and improve data entry accuracy," he said.


text:
Lost Time is Not Found Again
Suicide is stupid.
When I heard that my friend David Coady killed himself, I posted a link to an obituary about him followed by the words, "suicide is stupid."
I was not trying to say that people who commit suicide are lacking in mental capacity. David Coady was a very smart guy. Maybe too damn smart for his own good. Lots of people who commit suicide are too damn smart for their own good.
I was trying to insult suicide. I was trying to hurt suicide like suicide has hurt me. I could have said, "suicide sucks." But that didn't seem to get it. I could have said, "suicide is shit." But I didn't think that would be understood. So I said, "suicide is stupid."
I'm not exactly sure where I first met David Coady. It was probably at the San Francisco Zen Center during one of the times I gave a talk there. But I do clearly remember the first time I really bonded with him. I was walking around Tassajara breaking the rule of not singing by quietly singing the chorus to a Bob Dylan song called Odds And Ends. It's from his Basement Tapes album. The final line of the chorus is, "lost time will not be found again."
That line reminded me of the poem that's carved into all of the hans at Tassajara. A han is a little wooden board that's struck with a wooden mallet to call people to zazen or other events. On each one is written a translation of the following Chinese poem.
Shou ji ji dai
Mu jou jin soku
Kou in oshimu beshi
Toki hitowo matazu
(This Japanese phonetic translation does not follow the Chinese exactly)
Great is the matter of Birth and death
Life slips quickly by
To waste time is a great shame
Time waits for no one
There are different translations on each han at Tassajara. I've posted a photo of the han that was nearest to my room when I stayed there last summer. I wrote a piece about this poem last year.
David immediately recognized what I was singing. He told me that he was a great fan of Dylan. He said that before he moved to Tassajara he'd had a massive collection of CDs. The only ones he'd brought with him were a set of bootlegs of rare Dylan recordings, many from the same sessions that produced the Basement Tapes album. He asked if I wanted to copy them. I did. And the copies of those files are still on the computer I'm using to write this.
Later on a fire swept through the valley in which Tassajara is located. A small group of monks stayed behind and saved most of the monastery from burning. Only a couple of structures burned. One of those was David's cabin. All of his Bob Dylan CDs melted into goo.
Some time later I bought David a copy of a book called Million Dollar Bash. It's all about the sessions that produced that Dylan album. I gave the book to him the next time I saw him at the Zen Center.
Maybe a year ago David Coady attempted suicide at the San Francisco Zen Center. He failed that time. I can't remember if I gave him the book before or after that. I also can't remember if I copied those Dylan songs off my hard drive onto CDs for him. I think I did. My memory is shit. Always has been. As long as I can remember, anyway.
I know I didn't see David more than a couple times after his suicide attempt. I know that at least one of the times we talked, the subject came up and we swiftly moved on to other topics. It seemed like it was deeply embarrassing to him.
David Coady was a funny guy. He should have gone on the road with a stand-up act. I told him that once and he said people were always telling him that. He said he didn't feel he had it in him to talk in front of people. But he was naturally funny and always poignantly so. He was from Boston and talked in a really heavy Boston accent.
I'm very sad that he's gone now.
Suicide is stupid


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This page lists several forthcoming Perl and Linux related events. Most will be attended by at least a few members of the Birmingham Perl Mongers, so keep an eye out for us and say hello.
If you know of, or are organising any events that our members may be interested in attending, please email email@example.com with details.
You can now download the latest ICalendar
for all forthcoming Birmingham PerlMonger events,
or you can now subscribe to our Google Calendar by clicking the button below.
|12th February 2020 - February Social Meeting
|The Dragon Inn
|Hurst Street, Birmingham, B5 4TD
|See our social meetings pages for further details, http://birmingham.pm.org/meet/main
|Social Meetings
From the South
From M40 join the M42 and then take either the A34 or the A45 in the direction of Birmingham. These will both eventually bring you on to the A41 (Digbeth High Street/Deritend). As you enter the City Centre you will pass the Irish Community Centre on your left-hand side and the next turning on the left, just before Birmingham Coach Station, should be Rea Street. Turn left here, and at the first junction with Bradford Street turn right. Take the next left onto Sherlock Street, and follow the road round until you reach the mini roundabout. Take the first exit, and turn left at the first set of traffic lights on to Hurst Street. At the next set of traffic lights, Bromsgrove Street crosses Hurst Street. Although you cannot go straight on, the venue is about 50 yards further up Hurst Street on the right. For parking see below.
From the North
Leave the M6 at Junction 6 and join the A38M in the direction of Birmingham City Centre. As you approach the City Centre you will see the University of Aston on your left-hand side. Stay on the A38 as you go OVER the flyover, UNDER the underpass and THROUGH the tunnel. On exiting the tunnel, bear left onto the slip road, up onto the roundabout with the Pagoda in the centre. Head straight across the roundabout, and take the second left hand side street (Essex Street). Take the next left (Hurst Street) along side the rear of the Hippodrome. For parking see below.
From the South West
Leave the M5 at Junction 4 and follow the Bristol Road (A38) into Birmingham City Centre. After the major set of traffic lights, with the MacDonalds Drive-Thru on your left, continue straight on along the dual carriage way, but stay in the right or middle lane. As you approach the underpass, keep left and take the slip road up to the roundabout (follow signs for New Street station). At the roundabout you will see the Pagoda in the centre, and the Radisson Hotel diagonally opposite. Follow the roundabout all the way around, as it turning round and heading back onto the Bristol Road. Once on the slip road, take the second left hand side street (Essex Street). Then take the next left (Hurst Street) along side the rear of the Hippodrome. For parking see below.
On street parking is available (free after 6pm) on Hurst Street and Bromsgrove Street (at the traffic lights on Hurst Street). The Arcardian car park entrance is on Bromsgrove Street, although charges are quite expensive.
From Birmingham New Street Station
The venue is 5-10 minutes walking distance. Take the right hand exit out of the turnstiles of the station (NOT up the escalators). Through the doors, past the taxi rank towards the New Bullring. Before reaching the shopping arcade, turn right onto Smallbrook Queensway, towards the traffic lights at the crossroads at the bottom of the short hill. Turn left and cross over the traffic lights towards the Chinese Quarter (underneath the archway with offices on the top). Head straight towards the bar called 52 degrees (insert the o symbol here), crossing the road. carry on straight, past the Hippodrome on your right, towards The Old Fox on the corner. Walk past The Old Fox, and the crew entrance to The Glee Club, to the main entrance of the pub.
We are one of the UK's largest Perl user groups, representing Birmingham UK to the international Perl community since 2000. We hold monthly social and technical presentations, and several of our members are now regular attendees and speakers at the YAPC::Europe Perl Conferences.
For further information about Birmingham.pm, please read our Frequently Asked Questions page.
For details about joining our mailing list, please Click Here for more details.
14th October 2020
BrewDog Birmingham
81 John Bright St, Birmingham B1 1BL. 6pm onwards
Click Here for more details.
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Who does not like a good night's sleep? I am sure a lot of people would like to have sex with a prostitute. I would love to hook up with one because I enjoy getting paid to go to the club and have a good time. After all it is just sex!
There are many instances when young ladies say they need to make some extra money. Even though you would think the vast majority of these women are truly struggling women, the reality is that there are quite a few women out there who think they can turn tricks for a living. Yes, it may sound good to make a lot of money but it is not at all what most of these girls are expecting. Once they get into the business they start working hard, which makes it easier for them to take money from customers.
Well, the simple fact is they don't usually earn that much more than someone who has been a prostitute for a long time. The problem is the practice of prostitution is illegal in almost every state in the country.
Now, you might think the brothels are a big business but in reality they are a very small one. Those who run these establishments do this because they enjoy having a "cash cow" to milk for all the tax payers have to pay.
These establishments do this because they make a good amount of money off of the prostitutes. Prostitutes are the ones who get the tips and then they split that percentage of the tip with the pimps and the managers. Then there is also the problem of the minors.
Many of the young girls who work in the brothels have gotten into trouble. They have gotten pregnant or gotten drunk. You might say the young girls are vulnerable and it is not really uncommon, but what happens when the pimps or others find out about this?
If this is what happens, you can bet your business is going to get closed down or even worse, the government will shut down the brothel. These are just some of the reasons why the brothels cannot keep running. It just does not make sense.
Who ever thought a woman would get involved in prostitution? For some reason women become attracted to men who are well off and they are lured into this activity. In some ways it is easy to understand why this happens.
The only people who really get involved in prostitution are the women who are in the business for the wrong reasons and they do it for the same reason. If a man sees a pretty young lady that he wants to have sex with, they see him as their equal, as something they can control.
The other problem is that the law does not care about the prostitutes or how they use the money. The federal government believes these women are there to provide services and not be exploited. They will not protect these women and they will not go after the pimps either.
There are laws out there that can help protect these women and these johns. It will require the women to get their act together and to find another way to make money. Until that happens a brothel owner can forget about it and the pimp can continue to get away with raping and murdering prostitutes.
Are you interested in a woman's welfare? Do you think we should change the law to protect women?
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text:
Page View
Edwards, George, 1694-1773. / A natural history of birds. Most of which have not been figur'd or describ'd, and others very little known from obscure or too brief descriptions without figures, or from figures very ill design'd.
[Part I] (1743)
The blue creeper ; The golden-headed black tit-mouse, pp. [Plate] 21-21
Page [Plate] 21
This material may be protected by copyright law (e.g., Title 17, US Code).| For information on re-use, see http://digital.library.wisc.edu/1711.dl/Copyright


text:
Premium Meetings and Support
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text:
Along with partners committed to changing the world, Dr. Michael Youssef is leading the way for people living in spiritual darkness to discover the light of Christ. By passionately proclaiming uncompromising Truth through creative methods, this international team of experts is uniquely providing hope that is revolutionizing lives at home — and around the world.
Now celebrating 26 years of ministry,Leading The Way's television and radio programs are broadcast in more than 24 languages, covering more than 190 countries. Leading The Way also produces DVDs, CDs, books, a monthly devotional magazine, solar-poweredNavigators, and daily e-devotionals to spread the light of Christ. In 2009, the ministry launched THE KINGDOM SAT television channel to broadcast Biblical Truth from 50 ministry partners to five continents on five satellite platforms in English, Arabic and French. Leading The Way also partners internationally with in-country follow-up teams to encourage new believers in their faith, helping God's Kingdom to grow around the world and funds Help The Persecuted to provide vital aid to believers being persecuted for their faith in Christ.
Dr. Youssef and the Leading The Way staff are committed to sharing the Gospel with the lost and equipping believers to grow into a deeper walk with Christ. To learn how you can partner with this unique ministry,contact us.
Michael Youssef, Ph.D., is the Founder and President of Leading The Way with Dr. Michael Youssef, a worldwide ministry that leads the way for people living in spiritual darkness to discover the light of Christ through the creative use of media and on-the-ground ministry teams. His weekly television programs and daily radio programs are broadcast more than 4,000 times per week in 24 languages to more than 190 countries. He is also the founding pastor of The Church of The Apostles in Atlanta, Georgia.
Dr. Youssef was born in Egypt, lived in Lebanon and Australia before coming to the United States. In 1984, he fulfilled a childhood dream of becoming an American citizen. He holds degrees from Moore College in Sydney, Australia, and from Fuller Theological Seminary in California. In 1984, he earned a Ph.D. in social anthropology from Emory University. He has authored more than 30 books, including the most recent, God, Just Tell Me What to Do. He and his wife reside in Atlanta and have four grown children and seven grandchildren.


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General Information
Listening to your iPod on the go is even more convenient with this stereo headset. This headset features great sound quality and bass response as well as enhanced sound. The sleek caps ensure the headphones fit comfortably and securely in your ear. It supports all other players with a headphone port. iBud makes you relax and enjoy your music easier than ever.


text: Ellen Page Online - Press archive - Indie time: Sundance sets focus on low-budget film Indie time: Sundance sets focus on low-budget film published on Wednesday, January 16, 2013 - 8:17 AM PST It's that time of year again when a tiny ski-resort town becomes the place to be for anyone in show business - stars and directors, distribution executives, musicians, unknown filmmakers hoping that people might want to hear the stories they tell. Opening Thursday, the Sundance Film Festival takes over Park City for a week and a half every January. Anything resembling a theater is booked with screenings. Directors and their casts trudge snowy streets to introduce films and do interviews. Bars and restaurants are stuffed with people talking deals, or just talking about something crazy or unexpected they just saw on screen. "It's almost like Burning Man. Once a year, this tiny little town that then transforms itself into kind of a crazy film city for 10 days out of the year," said writer-director Lynn Shelton, a Sundance regular (Humpday, Your Sister's Sister) who returns this year with Touchy Feely, starring Rosemarie DeWitt as a massage therapist suddenly struck by an aversion to touching others. "It's crammed with people all there for one reason. Whatever relationship they have to the industry, they're all there for the love of films." The top U.S. showcase for independent cinema, Sundance has grown along with the do-it-yourself film world and has played a huge role in creating opportunities for low-budget filmmakers to get their work made and seen. Robert Redford added the festival in 1985 as an offshoot of his Sundance Institute that offers professional support to indie filmmakers. That first year, the festival showed a couple of dozen films. This year, Sundance is playing 119 feature films from 32 countries, culled from about 4,000 that were submitted. "It's gotten pretty overwhelming," Redford said. "I never dreamed when we started - we didn't even know that we would last - and then when it lasted and grew, it became huge. I never anticipated that it would get to this size." Now the name Sundance is almost a synonym for the possibilities of independent film. The festival helped launch the careers of filmmakers such as Steven Soderbergh, Kevin Smith and Quentin Tarantino and has premiered such Academy Award winners and nominees as Little Miss Sunshine, Precious, Winter's Bone and last year's top Sundance prize winner, Beasts of the Southern Wild. This year's lineup includes Ashton Kutcher as Apple co-founder Steve Jobs in director Joshua Michael Stern's film biography jOBS; Amanda Seyfried as porn star Linda Lovelace in Rob Epstein and Jeffrey Friedman's Lovelace; Shia LaBeouf and Evan Rachel Wood in Fredrik Bond's romance The Necessary Death of Charlie Countryman; Dakota Fanning and Elizabeth Olsen in Naomi Foner's teen tale Very Good Girls; Daniel Radcliffe as Allen Ginsberg in John Krokidas' beat-poet story Kill Your Darlings; and Ethan Hawke and Julie Delpy in Richard Linklater's Before Midnight, a follow-up to Before Sunrise and Before Sunset. There's also a reunion for two Little Miss Sunshine stars: Steve Carell and Toni Collette co-star in Nat Faxon and Jim Rash's Sundance premiere The Way, Way Back. Redford has insisted on giving documentaries equal time with dramatic features, and this year's festival has a wild range of nonfiction topics, including Barbara Kopple's Running from Crazy, a study of Mariel Hemingway and her family's history of mental illness and suicide, including that of grandfather Ernest Hemingway; Alison Ellwood's History of the Eagles Part 1, a portrait of the pop super-group; Alex Gibney's We Steal Secrets: The Story of WikiLeaks; Foo Fighters singer Dave Grohl's Sound City, a look at a venerable recording studio; Freida Mock's Anita, a portrait of Anita Hill, who accused Supreme Court nominee Clarence Thomas of sexual harassment; and R.J. Cutler and Greg Finton's The World According to Dick Cheney, an examination of the former vice president. "The company is such good company. The programmers at Sundance, their taste is impeccable," said Lucy Walker, who premiered her 2010 documentaries Countdown to Zero and Waste Land and returns this year with The Crash Reel, chronicling the recovery of snowboarder Kevin Pearce from a traumatic brain injury. "I feel like right now, the documentary field at Sundance, it's just such a remarkable collection of top-quality films." Actress and filmmaker Lake Bell, who directed a short film that premiered at Sundance in 2011 and co-starred in last year's festival feature Black Rock, said coming to Park City in January reminds her of going back to college. There's a campus spirit among festival organizers, audiences and especially the filmmakers, said Bell, who returns this time with her feature directing debut, In a World ..., in which she plays a woman struggling to follow in her father's career as a voice-over star. Festival organizers even like to call the year's group of filmmakers the "Class of 2013." Like college, Sundance is a safe haven, a place of camaraderie and mentoring before graduates have to head into the real world - in the case of filmmakers, before they have to cope with the business side of show business. "Sundance is right before the scary stuff starts. The judgment and the reviews and the forums, all that silly stuff," Bell said. "It's the purity before the storm." Festival director John Cooper jokes that he would not mind a real storm - something to maintain that purity and keep the real world from intruding on the little bubble of creative expression that is Sundance. "I hope we all do get snowed in," Cooper said. Source: www.cineplex.com


text:
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Additional Information
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As everyone is waking up to the wide world of marijuana and its products, everyone is finding out just how complicated cannabis is. As it turns out, there are at least 80 different types of cannabinoids alone, and 100 in cannabis and CBD hemp put together. CBD to THC ratios is from 20 to 1 up to 30 to 1; meaning the plant can contain CBD 20 percent and 0.6 percent THC.
Now, what the percentages and ratios mean will differ based upon individual states. In Colorado, those types of ratios are what make up industrial hemp, while other states define 1 percent as industrial hemp. Industrial hemp is not to be confused with the plant material that makes up rope and other manufactured products. High-CBD hemp, as it is known, is different than the fiber hemp used in production. Here's where the confusion is set in motion. Fiber hemp has 1 percent to 2 percent CBD.
Full-spectrum CBD is a powerhouse because it contains terpenes and cannabinoids together. CBD itself is only one small part of the cannabinoid family. Each is able to interact well with the endocannabinoid system. As research is performed, it is coming to light that the CBD has this interaction with the body. It's important that the natural structure and power of the cannabinoids are extracted without breaking down their ability to interact in the endocannabinoid system.
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Cannabis is very good for alleviating the pain and for improving the quality of life of terminally ill patients. The only problem is that smoking the leaves or the flowers may have negative consequences for the lungs. Some people have a sensitive respiratory system, thus not being able to enjoy the benefits of smoking cannabis. These people have to take CBD Capsules instead of smoking.
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Last but not least, CBD Capsules don't contain THC, which is present in marijuana leaves and flowers. When smoking cannabis, you inhale both CBD and THC, and this may cause various side effects that aren't always desirable. Pills contain only CBD, the non-psychoactive cannabinoid which is going to bring you the expected relief without hallucinations or other nasty side effects. Beware though, some of these pills may contain quite enough THC to cause a high. This is why you should always proceed with great caution when taking them. As a matter of fact, it's a very good idea to discuss with your doctor about your intention of taking CBD Capsules. This is how you can rest assured you'll have some quick medical help, should you experience adverse reactions or side effects that might endanger your life. Although you may be able to find these pills on the market, you shouldn't medicate yourself unless your physician gives you approval. Cannabis products are usually safe, but they may cause unpredictable reactions in some people. You may experience paranoia, confusion, sleepiness, drowsiness, lack of energy, sadness and even depression. As these symptoms can be quite severe, you shouldn't underestimate their effects. This is why you should inform your doctor about your intention of trying cannabis to alleviate your pain issues.
CBD is already a well-established remedy that can be used for medical purposes. Available in many forms, it seems to be fairly easy to find. However, if you intend to try it, you should consider the benefits of CBD sodftgels and use this form rather than smoking or vaporizing. Improving your quality of life is a desirable thing to do, but it shouldn't be achieved on the expense of your overall health and well-being. You need to protect your lungs and your whole respiratory system. This is why you should choose pills over smoking. Besides, thanks to the exact dosage and to their other benefits, pills are definitely the best CBD form available today.


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Verizon Communications' fourth-quarter loss widened, dragged down by restructuring, pension and Superstorm Sandy costs. The company activated a record number of new devices on its contract-based plans during the period.
The parent of the country's biggest wireless carrier lost $4.23 billion, or $1.48 per share, for the period ended Dec. 31. That compares with a loss of $2.02 billion or 71 cents per share, a year ago.
Adjusted earnings were 38 cents per share, which includes 7 cents per share for Superstorm Sandy. When stripping out Sandy's impact, earnings were 45 cents per share.
Operating revenue rose 6 percent to $30.05 billion from $28.44 billion.
Analysts polled by FactSet expected earnings of 50 cents per share on revenue of $29.82 billion.
The company's stock fell 84 cents, or 2 percent, to $41.70 in premarket trading Tuesday.
Verizon Wireless revenue climbed 9.5 percent to $20 billion. At the wireline division, operating revenue fell 1.5 percent to $10 billion.
Verizon Communications Inc. activated 2.1 million net new devices on contract-based plans, helped by the iPhone 5's launch and by data plans rolled out over the summer.
There were 144,000 FiOS Internet and 134,000 FiOS Video net additions in the quarter, bringing the company to a total of 5.4 million FiOS Internet and 4.7 million FiOS Video customers.
For the year, Verizon Communications earned $875 million, or 31 cents per share. In the previous year it earned $2.4 billion, or 85 cents per share. Annual operating revenue increased to $115.85 billion from $110.88 billion.
Total debt for 2012 declined to $52 billion from $55.2 billion.
Verizon's report marks the debut for telecommunications companies this earnings season. Rival AT&T Inc. reports on Thursday.


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Jolt Awards 2014: The Best Programmer Libraries, April 22, 2014 Astonishing collections of software bundled with superb design and coding tools
Programmer libraries these days are astonishing collections of software: not only vast amounts of functionality, but, as many of the images in this slide deck illustrate, they come bundled with superb design and coding tools. This a far cry from the libraries of even ten years ago, when libraries were much more narrowly focused. Today, they are all rambling, omnibus offerings.
What they do lack, however, is portability. Almost all the libraries we examined in this round were Windows-only products. This disappointing platform-centrism is purely the result of the economics: Development organizations on Windows are willing to pay for their products, while those on other platforms (notably Linux and Java) have a deeply entrenched tradition of free, generally open-source, products. The dollars surely make a difference, as we can see by the quality of the offerings, especially Windows UX suites and their extraordinary range of features.
We evaluated nearly 20 nominees and ultimately chose seven finalists, which we then looked at in great depth. The vote tally ranked the top six products as follows: three finalists, two runners up who are awarded the Jolt Productivity Award, and finally, the winner of the Jolt Award for best programmer library released during the last 12 months. The write-ups are presented in that order here. Unlike last year, in which the voting was very close, the Jolt Award winner this year led the field by a sizable margin a comparatively rare occurrence.
The judges in this category were: Mike Riley, Gary Evans, Gaston Hillar, Robert DelRossi, and Andrew Binstock.
Before we get to the winners, we would like to thank our Jolt sponsors: Rackspace for providing virtual machines for testing, and Safari Books Online for enabling online access to innumerable texts and resources that helped us look up items we needed to check on.
To the envelopes, then…


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No automotive work in the field:
Due to the ever growing complexities and specialized equipment and training necessary to work on today's automotive locking systems, we have decided to no longer open locked cars or work on them in the field. Our retail store locations (Fullerton & Orange) can work on automotive locks brought into our store for service and in some cases work on the cars themselves. Call us to speak with a store manager regarding your situation. Our retail stores will continue to make or duplicate automotive keys, including most high security and specialized chip keys.
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As a freckle-faced redhead, I'm constantly reminded to wear a hat and to slather myself with sunscreen. Even strangers on the street warn me to stay out of the sun. Unfortunately, I'm now faced with the fact that even these safeguards may not be enough to protect me from skin cancer. New research in Nature suggests redheads may be genetically predisposed to melanoma, even if they never see a ray of UV light.
Pigment production is controlled by a gene called MC1R, and is responsible for the veritable rainbow of human complexions. The relative abundance of two pigments (pheomelanin and eumelanin) determines hair and skin color. In dark-skinned individuals with dark hair, MC1R activity leads to production of large amounts of eumelanin, compared to relatively small amounts of pheomelanin. Redheads with fair skin have mutations that disrupt the MC1R pathway, producing more pheomelanin than eumelanin. We've long known that redheads are at a high risk of sun-induced skin cancer, but the researchers behind this study wondered whether something about pheomelanin itself may contribute to the high incidence of melanoma in those with fair skin, even in the absence of cancer-causing UV exposure.
To investigate this potential link, the researchers used strains of mice with pigment profiles that mimicked various human complexions. Like humans with dark skin, control mice with black coats had an intact MC1R gene and produced much more eumelanin than pheomelanin. A second strain of mice, with a mutated MC1R gene, had reddish coats and had a much higher pheomelanin to eumelanin ratio. The third strain of mice was albino, which produced no pigment at all.
Mice from each strain were then crossed with mice with a mutation called BRAFV600E, which has been implicated in the development of malignant melanoma. (Up to 60 percent of all human patients with melanoma have this mutation.) The researchers then monitored the mice over time, carefully making sure that they were not exposed to UV light or any other environmental cancer-causing agents.
Black and albino mice that carried the BRAFV600E mutation developed melanoma at a very low rate, and only after a long period of time. However, more than 50 percent of the red mice with the same mutation developed melanoma after just one year.
To determine whether pheomelanin itself was behind this extremely high incidence of cancer, the researchers halted pigment production in red mice by introducing an albino allele. After a year, melanoma incidence in these mice was no different than those in the black or albino mice, suggesting that something about the pheomelanin pathway itself may play a role in UV-independent melanoma.
It turns out that redheads may be vulnerable to more oxidative DNA damage, even if they stay out of the sun: the researchers found several indicators of DNA damage—lipid peroxide and two cyclopurine levels—were much higher in mice that produced large amounts of pheomelanin. This DNA damage, in turn, contributes to the development of malignant melanoma.
It has long been known that UV radiation causes skin cancer, especially in fair-skinned redheads, but these results suggest that even redheads that stay out of the sun aren't completely protected from melanoma. The same pigment pathway that gives them their fiery hair and freckles may actually damage their DNA and lead to melanoma, without any help from the sun's rays. Unfortunately, it's still unclear how to stop this damage. Experts advise redheads to visit the dermatologist regularly, and suggest that increasing oral antioxidant intake might decrease melanoma risk.
But, of course, don't throw away that sunscreen; sun exposure is still the leading risk factor for skin cancer, in both redheads and others.
Nature, 2012. DOI: 10.1038/nature11624 (About DOIs).


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Autostadt in Wolfsburg, located right next door to the Volkswagen factory on the Mittelland Canal, is an innovative discovery centre and leisure park for all the family. It is a veritable explosion of ideas, offering adventure for kids aged three upwards, attractions for car lovers and culinary surprises too.
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