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Here's what city of Fort Collins is celebrating, prioritizing: recap of State of the City
Fort Collins community members and leaders gathered at the Lincoln Center on Tuesday night for the city's annual State of the City address, which looks both at the year in review and ahead to the coming year.
This year, the city also used the occasion to start the celebration of its sesquicentennial — or 150th birthday — and took time to go through how city services have changed and grown over the city's lifetime.
City Manager Kelly DiMartino and Mayor Jeni Arndt took the stage for a conversation about all things Fort Collins. If you weren't able to make it to the event, here's a recap of what was discussed.
2022 was a year of recovery
City leaders saw 2022 as a year of recovery and building back up from the impacts of the pandemic.
DiMartino and Arndt shared some highlights of the city's accomplishments, citing the city's persistence and staff dedication to recovery:
- The Museum of Discovery celebrating 10 years
- The first full year of the city's equity office
- Natural Areas turning 30
- Community canopy program that sold 1,000 trees at the reduced rate of $25 a tree
- Fort Collins police gaining enough mental health co-responders to have daily coverage
While Arndt and DiMartino spent some time talking about the successes of 2022, they also spent time talking about how far city services have come in 150 years.
DiMartino said a big part of the city's successes with utilities like electric and water services are from the "foresight our predecessors had in doing underground facilities." She pointed to Connexion, the city's municipal broadband service, as an example of how we're still utilizing that kind of distribution.
Arndt acknowledged the challenges with Connexion's launch but said the city always knew it wasn't going to be easy. "We take big risks. We look to the future, and we know it's gonna pay off," she said.
DiMartino pointed out some fun-fact changes Fort Collins has seen over the years, including that in 1925 the city received its first stop light and now there are more than 2,000 miles of road throughout the city, and that transportation was a streetcar service in 1974 and now the city has two battery-powered buses.
2023 promises more community engagement, 'red hot' topics
In 2023, the city wants to move from a phase of recovery into one of resilience.
"We're not going to just go back to normal, but we're going to build back better, and we're going to bounce forward," Arndt said.
And one way they're planning to do that is through improved engagement work in the community with what Arndt called "red hot" topics, including the recently overturned land use code changes.
The proposed land use code updates were one of the highly anticipated city happenings of 2022, but after a successful grassroots campaign against the changes, council repealed their adoption of the changes rather than send the decision to a citywide vote.
"The council opted to repeal the code and engage in a much deeper community conversation," Arndt said. "I really honored that process, that democratic process, and look forward to the future discussions about how the built environment reflects the values and the visions of our community."
Arndt added that she hopes the community stays engaged in the process with the city "because it's really important work" and will give the city an opportunity to get its values into code.
Along with land use code revisions, Arndt and DiMartino named the future of the Hughes Stadium site as a major topic for the city this year. Arndt said they're still working to acquire the property — staff previously said they expect the sale to close in March — and are continuing to engage the community to determine the best use for the land.
"We know there are a lot of differing opinions about that, and that's why our community engagement efforts are really so important," DiMartino said.
In addition to improving engagement, the city hopes to continue its equity work in 2023 with leadership, saying it "is not something we do separately, it is a part of the work we do."
One major step toward improving equity relations is creating a "draft equity plan" that will help guide the city's work, said DiMartino, noting that there's so much to be done and that will help keep it focused.
They're also going to work on "building deep relationships" with historically underrepresented communities.
"One community that we're focusing on is our Native American community," DiMartino said. "I am happy to say that we have hired an Indigenous community engagement specialist for the first time in the city organization, and we really want to work on rebuilding and building deep and authentic trusts with those community members."
Molly Bohannon covers city government for the Coloradoan. Follow her on Twitter @molboha or contact her at firstname.lastname@example.com. Support her work and that of other Coloradoan journalists by purchasing a digital subscription today.

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Systemic sclerosis (SSc) is an autoimmune disease characterised by microvasculopathy, immune dysregulation, and skin and visceral organ fibrosis. Every year novel insights into the pathogenesis, organ involvement and treatment of this severe disease are published in the scientific community.In this review we report an overview of some of the most relevant contributions published in 2021.
Subject(s)Autoimmune Diseases , Scleroderma, Systemic , Humans , Scleroderma, Systemic/diagnosis , Scleroderma, Systemic/therapy , Fibrosis , Autoimmune Diseases/complications , Skin/pathology
BACKGROUND: Severe acute respiratory syndrome coronavirus 2 may be associated with late-onset necrotizing myositis, mimicking autoimmune inflammatory myositis; however, the exact underlying pathogenesis of severe acute respiratory syndrome coronavirus 2-induced myositis is still unclear. CASE PRESENTATION: Herein, we report a rare case of necrotizing autoimmune myositis in a 67-year-old middle eastern male following coronavirus disease 2019 infection, who presented with muscle weakness. The patient had positive anti-NXP2. The diagnosis of necrotizing autoimmune myositis was made according to muscle weakness, increased liver enzymes, electromyography and nerve conduction velocity results, and muscle biopsy. The patient underwent a full malignancy evaluation, which was unremarkable, and was discharged in relatively well condition with a daily dose of 1 mg/kg prednisolone and azathioprine 150 mg (2 mg/kg). CONCLUSION: Our report highlights the already known possible protracted sequence of coronavirus disease 2019 infection and the potential for delayed-onset necrotizing myositis.
Subject(s)Autoimmune Diseases , COVID-19 , Myositis , Male , Humans , Aged , COVID-19/complications , Myositis/diagnosis , Myositis/drug therapy , Autoimmune Diseases/complications , Autoimmune Diseases/diagnosis , Muscle Weakness , Prednisolone , SARS-CoV-2
After the first reporting of the index case of Severe Acute Respiratory Syndrome (SARS)-CoV-2-associated disease at the end of December 2019, the virus spread quickly throughout the world, prompting the WHO on 11 March 2020 to declare the disease a global pandemic. The coronavirus disease 2019 (COVID-19) pandemic, raises concerns for all people, mainly for susceptible population. People with pre-existing diseases, especially individuals with autoimmune disorders, are more at the risk of SARS-CoV-2 infection because of compromised immune system due to frequent use of immunosuppressive drugs and steroids. Patients with autoimmune diseases and their physicians have concerns about these patients' healthcare, since they are at a higher risk for COVID-19 infection, may show severe complications of COVID-19, and may experience probable flares of their pre-existing disease. Even though there have been several studies discussing the relation between COVID-19 and various types of autoimmune diseases, it cannot be ascertained that all patients with autoimmune diseases experience more severe complications of COVID-19 and have more hospitalization or mortality rate. The situation depends on each patient's condition, such as the type and the severity of the underlying autoimmune disease and the kind of treatment they receive. In the present review, we have discussed the effects of COVID-19 pandemic on patients with different autoimmune diseases and their relative concerns about their treatments. As a result, we have reviewed further considerations that should be taken into account for these patients during the pandemic or when they are infected with COVID-19.
Subject(s)Autoimmune Diseases , COVID-19 , Humans , COVID-19/complications , SARS-CoV-2 , Pandemics , Autoimmune Diseases/complications
Autoimmune diseases are known to be a risk factor for severe COVID-19 infection. This is the first case series of patients with autoimmune disease suffering from COVID-19 infection in Jakarta, Indonesia. There were 12 confirmed cases of COVID-19 infection in autoimmune patients from March 2020 until February 2021. We select 5 patients in this case series. Three of them had systemic lupus erythematous (SLE), one of them had rheumatoid arthritis, and one of them had ankylosing spondylitis. Three of them had high BSR Risk Stratification. Most of them had used daily steroid therapy. Fatigue, abdominal pain, diarrhea, and cough were the common symptoms found. None of the patients were admitted to ICU, used mechanical ventilators, and all of them survived. Most of the patients were prescribed anti-coagulant therapy. This first comprehensive case series can provide valuable information regarding the clinical characteristics of COVID-19 infection in the Indonesian autoimmune disorder patient population.
Subject(s)Arthritis, Rheumatoid , Autoimmune Diseases , COVID-19 , Lupus Erythematosus, Systemic , Spondylitis, Ankylosing , Humans , Lupus Erythematosus, Systemic/complications , Lupus Erythematosus, Systemic/drug therapy , Autoimmune Diseases/complications , Autoimmune Diseases/epidemiology , Arthritis, Rheumatoid/drug therapy , Arthritis, Rheumatoid/epidemiology , Spondylitis, Ankylosing/drug therapy , Spondylitis, Ankylosing/epidemiology
OBJECTIVES: To calculate the rates of COVID-19 infection and COVID-19-related death among people with rare autoimmune rheumatic diseases (RAIRD) during the first wave of the COVID-19 pandemic in England compared with the general population. METHODS: We used Hospital Episode Statistics to identify all people alive on 1 March 2020 with ICD-10 codes for RAIRD from the whole population of England. We used linked national health records (demographic, death certificate, admissions and PCR testing data) to calculate rates of COVID-19 infection and death up to 31 July 2020. Our primary definition of COVID-19-related death was mention of COVID-19 on the death certificate. General population data from Public Health England and the Office for National Statistics were used for comparison. We also describe COVID-19-related hospital admissions and all-cause deaths. RESULTS: We identified a cohort of 168 680 people with RAIRD, of whom 1874 (1.11%) had a positive COVID-19 PCR test. The age-standardized infection rate was 1.54 (95% CI: 1.50, 1.59) times higher than in the general population. A total of 713 (0.42%) people with RAIRD died with COVID-19 on their death certificate and the age-sex-standardized mortality rate for COVID-19-related death was 2.41 (2.30-2.53) times higher than in the general population. There was no evidence of an increase in deaths from other causes in the RAIRD population. CONCLUSIONS: During the first wave of COVID-19 in England, people with RAIRD had a 54% increased risk of COVID-19 infection and more than twice the risk of COVID-19-related death compared with the general population. These increases were seen despite shielding policies.
Subject(s)COVID-19 , Rheumatic Diseases , Autoimmune Diseases/complications , Autoimmune Diseases/mortality , COVID-19/mortality , COVID-19/therapy , Cause of Death , England/epidemiology , Hospitalization , Humans , Pandemics , Rheumatic Diseases/complications , Rheumatic Diseases/mortality
OBJECTIVES: To evaluate long-term kinetics of the BNT162b2 mRNA vaccine-induced immune response in adult patients with autoimmune inflammatory rheumatic diseases (AIIRD) and immunocompetent controls. METHODS: A prospective multicentre study investigated serum anti-SARS-CoV-2 S1/S2 IgG titre at 2-6 weeks (AIIRD n=720, controls n=122) and 6 months (AIIRD n=628, controls n=116) after the second vaccine, and 2-6 weeks after the third vaccine dose (AIIRD n=169, controls n=45). T-cell immune response to the third vaccine was evaluated in a small sample. RESULTS: The two-dose vaccine regimen induced a higher humoral response in controls compared with patients, postvaccination seropositivity rates of 100% versus 84.72%, p<0.0001, and 96.55% versus 74.26%, p<0.0001 at 2-6 weeks and at 6 months, respectively. The third vaccine dose restored the seropositive response in all controls and 80.47% of patients with AIIRD, p=0.0028. All patients treated with methotrexate monotherapy, anticytokine biologics, abatacept and janus kinase (JAK) inhibitors regained the humoral response after the third vaccine, compared with only a third of patients treated with rituximab, entailing a 16.1-fold risk for a negative humoral response, p≤0.0001. Cellular immune response in rituximab-treated patients was preserved before and after the third vaccine and was similar to controls. Breakthrough COVID-19 rate during the Delta surge was similar in patients and controls, 1.83% versus 1.43%, p=1. CONCLUSIONS: The two-dose BNTb262 regimen was associated with similar clinical efficacy and similar waning of the humoral response over 6 months among patients with AIIRD and controls. The third vaccine dose restored the humoral response in all of the controls and the majority of patients.
Subject(s)Autoimmune Diseases , BNT162 Vaccine , COVID-19 , Immunogenicity, Vaccine , Rheumatic Diseases , Abatacept/therapeutic use , Adult , Antibodies, Viral , Antirheumatic Agents/therapeutic use , Autoimmune Diseases/complications , Autoimmune Diseases/drug therapy , BNT162 Vaccine/immunology , COVID-19/prevention & control , Humans , Immunoglobulin G/therapeutic use , Janus Kinases , Methotrexate/therapeutic use , Prospective Studies , Rheumatic Diseases/drug therapy , Rituximab/therapeutic use
The ongoing COVID-19 pandemic has raised concerns regarding the outcome of this infection in patients with autoimmune bullous dermatoses (AIBDs) due to effect of drugs used to treat these disorders. This investigation was performed from the onset of the pandemic to June 1, 2021. Patients with AIBDs who contracted COVID-19 were evaluated. A generalized linear model was employed to find the predictors of severe COVID-19 among patients with AIBDs. Ninety-three patients with AIBDs with a mean age of 50.3 years were evaluated. The most COVID-19 related symptoms were tiredness (76.3%) myalgia (69%), and cough (63.4%). During follow-up, the rate of hospitalization and death were 45.2% and 4.3%, respectively. Previous comorbidities (ß = 0.61) and mean prednisolone dosage above 10 mg/day in the last 3 months (ß = 1.10) significantly increased COVID-19 severity. Also, vaccination against SARS-CoV-2 (ß = -1.50) and each passing month from the last rituximab dose decreased severity (ß = -0.02). Notably, 19.3% of the patients developed AIBD flare-ups following COVID-19 infection. Higher prednisone dose and the shorter interval from the last rituximab infusion were determinants of severe COVID-19. Physicians should assess the risk versus the benefits when prescribing the medications. Moreover, vaccination could successfully attenuate COVID-19 severity.
Subject(s)Autoimmune Diseases , COVID-19 , Skin Diseases, Vesiculobullous , Autoimmune Diseases/complications , Autoimmune Diseases/drug therapy , Cohort Studies , Humans , Middle Aged , Pandemics , Rituximab , SARS-CoV-2 , Skin Diseases, Vesiculobullous/diagnosis , Skin Diseases, Vesiculobullous/drug therapy
COVID-19 has been related to several autoimmune diseases, triggering the appearance of autoantibodies and endothelial dysfunction. Current evidence has drawn attention to vasculitis-like phenomena and leukocytoclastic vasculitis in some COVID-19 patients. Moreover, it has been hypothesized that COVID-19 could induce flares of preexisting autoimmune disorders. Here, we present two patients with previously controlled IgA vasculitis who developed a renal and cutaneous flare of vasculitis after mild COVID-19, one of them with new-onset ANCA vasculitis. These patients were treated with glucocorticoids and immunosuppressants achieving successful response. We also provide a focused literature review and conclude that COVID-19 may be associated with triggering of vasculitis and could induce flares of previous autoimmune diseases.
Subject(s)Autoimmune Diseases , COVID-19 , IgA Vasculitis , Vasculitis, Leukocytoclastic, Cutaneous , Vasculitis , Autoimmune Diseases/complications , COVID-19/complications , Humans , IgA Vasculitis/complications , IgA Vasculitis/diagnosis , IgA Vasculitis/drug therapy , Vasculitis/complications , Vasculitis/etiology , Vasculitis, Leukocytoclastic, Cutaneous/complications , Vasculitis, Leukocytoclastic, Cutaneous/etiology
Autoimmune thyroid diseases (AITD) are a heterogeneous group of disorders. They include, in particular, Graves' disease and Hashimoto's thyroiditis with a wide range of different functional status ranging from subclinical biochemical abnormalities to severe hyperthyroidism or severe hypothyroidism respectively. Furthermore, other conditions more frequently infectious or drug related can cause an immune reaction in the thyroid tissue. In AITDs, positron emission tomography/computed tomography (PET/CT) does not play a primary role for disease diagnosis or management, but accidental findings can occur in both symptomatic and asymptomatic patients, and they should be recognized and well interpreted. A comprehensive literature search of the PubMed databases was conducted to identify papers (systematic review, prospective and retrospective study, case report) evaluating the role of PET/CT in thyroid autoimmune diseases. Thyroid diffuse uptake of 18F-fluoro-2-deoxy-2-d-glucose ([18F]FDG) has been shown to be frequently associated with AITDs, but also with immune-induced thyroid disorders related to SARS-CoV-2 or immunotherapy, while malignant lesions more often have a focal aspect. Other radiopharmaceuticals as [68Ga]-DOTA-peptides, [68Ga]-fibroblast activation protein inhibitors (FAPIs) and [68Ga]-prostate specific membrane antigen ([68Ga]-PSMA) showed similar findings. In conclusion, PET/CT scan in AITDs does not play a primary role in the diagnosis, but the occasional finding of a thyroid uptake must always be described in the report and possibly investigated for a better patient's management.
Subject(s)Autoimmune Diseases , COVID-19 , Graves Disease , Autoimmune Diseases/complications , Autoimmune Diseases/diagnostic imaging , COVID-19/diagnostic imaging , Fluorodeoxyglucose F18 , Graves Disease/diagnostic imaging , Humans , Male , Positron Emission Tomography Computed Tomography/methods , Prospective Studies , Radiopharmaceuticals , Retrospective Studies , SARS-CoV-2
It remains unclear how effective COVID-19 vaccinations will be in patients with weakened immunity due to diseases, transplantation, and dialysis. We conducted a systematic review comparing the efficacy of COVID-19 vaccination in patients with solid tumor, hematologic malignancy, autoimmune disease, inflammatory bowel disease, and patients who received transplantation or dialysis. A literature search was conducted twice using the Medline/PubMed database. As a result, 21 papers were included in the review, and seropositivity rate was summarized by specific type of disease, transplantation, and dialysis. When different papers studied the same type of patient group, a study with a higher number of participants was selected. Most of the solid tumor patients showed a seropositivity rate of more than 80% after the second inoculation, but a low seropositivity was found in certain tumors such as breast cancer. Research in patients with certain types of hematological malignancy and autoimmune diseases has also reported low seropositivity, and this may have been affected by the immunosuppressive treatment these patients receive. Research in patients receiving dialysis or transplantation has reported lower seropositivity rates than the general population, while all patients with inflammatory bowel disease have converted to be seropositive. Meta-analysis validating these results will be needed, and studies will also be needed on methods to protect patients with reduced immunity from COVID-19.
Subject(s)COVID-19 Vaccines , COVID-19 , Immunogenicity, Vaccine , Autoimmune Diseases/complications , COVID-19/prevention & control , COVID-19 Vaccines/immunology , Humans , Inflammatory Bowel Diseases/complications , Neoplasms/complications , Transplant Recipients
INTRODUCTION: To assess the incidence and risk factors for breakthrough COVID-19 infection in a vaccinated cohort of patients with autoimmune rheumatic diseases (AIRDs) and determine whether antibodies to receptor binding domain of spike protein (anti-RBD) serve as a reliable predictor of susceptibility to such infections. METHODS: Patients with AIRDs who had completed two doses of SARS-CoV2 vaccines were included and anti-RBD antibodies were determined 4-6 weeks post the second vaccine dose and stratified into good responders (GR) (>212 IU), inadequate responders (IR) (0.8-212 IU) and non-responders (NR) (<0.8 IU). Patients who had completed a minimum of 8 weeks interval after the second dose of vaccine were followed up every 2 months to identify breakthrough infections. All sero converted patients who had contact with COVID-19 were also analysed for neutralising antibodies. RESULTS: We studied 630 patients of AIRDs (mean age 55.2 (±11.6) years, male to female ratio of 1:5.2). The majority of patients had received AZD1222 (495, 78.6%) while the remaining received the BBV152 vaccine. The mean antibody titre was 854.1 (±951.9), and 380 (60.3%) were GR, 143 (22.7%) IR and 107 (16.9%) NR.Breakthrough infections occurred in 47 patients (7.4%) at a mean follow-up of 147.3 (±53.7) days and were proportionately highest in the NR group (19; 17.75%), followed by the IR group (13; 9.09%) and least in the GR group (15; 3.95%). On log-rank analysis, antibody response (p<0.00001), vaccine(p=0.003) and mycophenolate mofetil (p=0.007) were significant predictors of breakthrough infections. On multivariate Cox regression, only NR were significantly associated with breakthrough infections (HR: 3.6, 95% CI 1.58 to 8.0, p=0.002). In sero converted patients with contact with COVID-19, neutralisation levels were different between those who developed and did not develop an infection. CONCLUSION: Breakthrough infections occurred in 7.4% of patients and were associated with seronegativity following vaccination. This provides a basis for exploring postvaccination antibody titres as a biomarker in patients with AIRD.
Subject(s)Autoimmune Diseases , COVID-19 , Antibodies, Viral , Autoimmune Diseases/complications , Autoimmune Diseases/drug therapy , Autoimmune Diseases/epidemiology , COVID-19/epidemiology , COVID-19 Vaccines , ChAdOx1 nCoV-19 , Female , Humans , Male , Middle Aged , Prospective Studies , RNA, Viral , SARS-CoV-2 , Survival Analysis
Vasculitides, a form of inflammatory autoimmune disease targeting the vessels, constitute an entity with significant morbidity and mortality. Infections have long been associated with vasculitides as a result of the incident immunosuppression following treatment induction and maintenance. Several microbial pathogens have been described as etiologic factors of infections in this patient population according to the type of vessels affected. Intense research has also been recently conducted in the interplay between vasculitides and certain viral infections, namely human immunodeficiency virus and severe acute respiratory syndrome coronavirus 2. Of note, a plethora of scientific evidence is available regarding the role of infections as triggering factors for vasculitides. Among the main mechanisms implicated in this direction are the activation of B and T cells, the direct endothelial insult, the immune complex-mediated vascular injury, and the cell-mediated, type IV hypersensitivity vessel damage. Therefore, this review aims to summarize all the available evidence concerning this bidirectional interplay between infections and vasculitides.
Subject(s)Autoimmune Diseases , COVID-19 , HIV Infections , Vasculitis , Antigen-Antibody Complex , Autoimmune Diseases/complications , COVID-19/complications , HIV Infections/complications , Humans , Vasculitis/etiology
BACKGROUND: The aim of this review is to explore whether patients with autoimmune diseases (AIDs) were at high risk of infection during the COVID-19 epidemic and how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic affected immune system. METHODS: A systematic literature search was performed using the foreign databases (NCBI, web of science, EBSCO, ELSEVIER ScienceDirect) and Chinese databases (WanFang, CNKI (China National Knowledge Infrastructure), VIP, CBM) to locate all relevant publications (up to January 10, 2021). The search strategies used Medical Search Headings (MeSH) headings and keywords for "COVID-19" or "SARS-CoV-2" or "coronavirus" and "autoimmune disease". RESULTS: This review evaluates the effect of SARS-CoV-2 on the immune system through ACE-2 receptor binding as the main pathway for cell attachment and invasion. It is speculated that SARS-COV-2 infection can activate lymphocytes and inflammatory response, which may play a role in the clinical onset of AIDs and also patients were treated with immunomodulatory drugs during COVID-19 outbreak. Preliminary studies suggested that the risk of developing severe forms of COVID-19 in patients with AIDs treated with immunomodulators or biologics might not increase. A large number of samples are needed for further verification, leading to an excessive immune response to external stimuli. CONCLUSION: The relationship between autoimmune diseases and SARS-CoV-2 infection is complex. During the COVID-19 epidemic, individualized interventions for AIDs should be provided such as Internet-based service.
Subject(s)Autoimmune Diseases/complications , Autoimmune Diseases/epidemiology , COVID-19/complications , COVID-19/epidemiology , Adenosine Monophosphate/analogs & derivatives , Adenosine Monophosphate/therapeutic use , Alanine/analogs & derivatives , Alanine/therapeutic use , Angiotensin-Converting Enzyme 2/metabolism , Arthritis, Rheumatoid/immunology , Autoimmune Diseases/immunology , Azetidines/therapeutic use , COVID-19/therapy , Dendritic Cells/virology , Humans , Immune System , Immunity, Innate , Immunization, Passive/trends , Inflammatory Bowel Diseases/immunology , Killer Cells, Natural/virology , Lupus Erythematosus, Systemic/immunology , Monocytes/virology , Multiple Sclerosis/immunology , Purines/therapeutic use , Pyrazoles/therapeutic use , Sulfonamides/therapeutic use , COVID-19 Drug Treatment , COVID-19 Serotherapy
Autoimmune diseases and infections are often closely intertwined. Patients with autoimmune diseases are more susceptible to infections due to either active autoimmune disease or the medications used to treat them. Based on infections as environmental triggers of autoimmunity, an autoimmune response would also be expected in COVID-19. Although some studies have shown the occurance of autoantibodies and the possible development of autoimmune diseases after SARS-CoV-2 infection, current data suggest that the levels of autoantibodies following SARS-CoV-2 infection is comparable to that of some other known infections and that the autoantibodies might only be transient. The risk of SARS-CoV-2 infection in patients with a systemic autoimmune rheumatic disease (SARD) appears slightly higher compared to the general population and the course of COVID-19 disease does not seem to be very different, however, specific therapies such as glucocorticoids and anti-TNF might modulate the risk of hospitalization/death. Cytokine release syndrome is a severe complication in COVID-19. Many drugs used for the treatment of SARD are directly or indirectly targeting cytokines involved in the cytokine release syndrome, therefore it has been suggested that they could also be effective in COVID-19, but more evidence on the use of these medications for the treatment of COVID-19 is currently being collected.
Subject(s)Autoimmune Diseases , COVID-19 Drug Treatment , COVID-19 , Rheumatic Diseases , Autoimmune Diseases/complications , Autoimmune Diseases/drug therapy , Autoimmune Diseases/immunology , COVID-19/complications , COVID-19/immunology , Humans , Rheumatic Diseases/complications , Rheumatic Diseases/drug therapy , Rheumatic Diseases/immunology , SARS-CoV-2
BACKGROUND: To date, it is unknown how many Italians have had or have a mild SARS-CoV-2 infection, because of the lack of epidemiological studies involving the general population. STUDY DESIGN: Aim of this study was to investigate the prevalence/incidence of a symptoms-based mild SARS-CoV-2 infection in southern Tuscany, by using an online survey. METHODS: An anonymous random middle-aged sample of 3,460 individuals completed the survey. A symptom-score ≥5, calculated on 195 patients with RT-PCR COVID-19 disease (sensitivity/specificity of 0.815/0.780 respectively) was used for the diagnosis. RESULTS: This cut-off highlighted that 12.3% of all the population might have had a SARS-CoV-2 infection, while 3.9% of them might have it at the time of the survey. Female sex (OR=1.334 [1.029-1.728]; p=0.030), obesity status (OR=1.961 [1.304-2.949]; p=0.001), asthma (OR=2.035 [1.433-2.890]; p=0.0001), autoim-mune diseases (OR=2.103 [1.381-3.201]; p=0.001), were all risk factors for showing mild SARS-CoV-2 infection. Instead, the elderly had a low probability to develop mild forms of the disease (OR=0.984 [0.975-0.994]; p=0.001). CONCLUSION: A remarkable number of subjects in Southern Tuscany may have already had a mild SARS-CoV-2 infection. Symptoms scores might be used to screen subjects with a suspected infection. Female sex, obesity, asthma, autoimmune diseases may be factors linked with mild forms of COVID-19 disease.
Subject(s)COVID-19/diagnosis , Public Health , Symptom Assessment/statistics & numerical data , Age Factors , Asthma/complications , Autoimmune Diseases/complications , COVID-19/epidemiology , Female , Health Surveys/methods , Health Surveys/statistics & numerical data , Humans , Incidence , Italy/epidemiology , Male , Middle Aged , Obesity/complications , Prevalence , Risk Factors , Sensitivity and Specificity , Sex Factors
Interferons are the best antiviral agents in vitro against SARS-CoV-2 so far and genetic defects in their signaling cascade or neutralization of alfa-interferons by autoantibodies come with more severe COVID-19. However, there is more, as the SARS-CoV-2 dysregulates not only innate immune mechanisms but also T and B cell repertoires. Most genetic, hematological and immunological studies in COVID-19 are at present phenomenological. However, these and antecedent studies contain the seed grains to resolve many unanswered questions and a whole range of testable hypotheses. What are the links, if existing, between genetics and the occurrence of interferon-neutralizing antibodies? Are NAGGED (neutralizing and generated by gene defect) antibodies involved or not? Is the autoimmune process cause or consequence of virus infection? What are the roles played by cytokine posttranslational modifications, such as proteolysis, glycosylation, citrullination and others? How is systemic autoimmunity linked with type 1 interferons? These questions place cytokines and growth factors at pole positions as keys to unlock basic mechanisms of infection and (auto)immunity. Related to cytokine research, (1) COVID-19 patients develop neutralizing autoantibodies, mainly against alpha interferons and it is not yet established whether this is the consequence or cause of virus replication. (2) The glycosylation of recombinant interferon-beta protects against breaking tolerance and the development of neutralizing antibodies. (3) SARS-CoV-2 induces severe inflammation and release of extracellular proteases leading to remnant epitopes, e.g. of cytokines. (4) In the rare event of homozygous cytokine gene segment deletions, observed neutralizing antibodies may be named NAGGED antibodies. (5) Severe cytolysis releases intracellular content into the extracellular milieu and leads to regulated degradation of intracellular proteins and selection of antibody repertoires, similar to those observed in patients with systemic lupus erythematosus. (6) Systematic studies of novel autoimmune diseases on single cytokines will complement the present picture about interferons. (7) Interferon neutralization in COVID-19 constitutes a preamble of more studies about cytokine-regulated proteolysis in the control of autoimmunity. Here we reformulate these seven conjectures into testable questions for future research.


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HR leaders at Zoom and WayUp reveal how a strong virtual recruiting process can improve diversity and inclusion
- Adding the word "remote" to a job isn't enough - think smartly about how you recruit virtually.
- A thorough
hiringprocess that's inclusive includes plenty of face time and transparency.
- This was part of Insider's virtual event "Transforming
HRin the Digital Era," presented by Paycom, on June 15.
Supporting new hires through a virtual recruitment and onboarding process the past year has meant organizations have had to rethink how they attract and retain talent - and it might be for the better.
"A lot of people throughout the pandemic had tried to stick the word 'remote' on whatever practice they were doing," Liz Wessel, cofounder and CEO of job site WayUp, said during Insider's recent virtual event "Transforming HR in the Digital Era," presented by Paycom, which took place on June 15. "They said, 'We could do the same thing but over
The panel, titled "Virtual Talent Acquisition," was moderated by Insider's
Oldham and Wessel both agreed that "intentionality" in the recruitment process is critical. When hiring online, you often miss out on those camaraderie-building, get-to-know-you conversations.
"It's really all about the setup," Oldham said. "Giving them all of the information about what the interview process is going to be like … describing the process for the day. So you have to intentionally do that upfront and then make sure that the person is understanding who they're going to meet, when they're going to meet them."
She said that Zoom has bridged the gap by undertaking more interviews, even though it elongates the hiring process. That way, potential hires get more of a window into the company and have more conversations that can help determine things like cultural fit.
When it comes to diversity, Oldham believes that companies need to apply the lessons of the pandemic to the "new normal."
"The pandemic really put us in a position of saying, 'We could hire anywhere.' It doesn't matter anymore - geography was actually a limiting factor to diversity," she said. "San Francisco, I believe, is around 5% Black, in a US population of 13%," she added.
While remote hiring may help with diversity, it could adversely affect inclusion. Liz Wessel said that when working from home, circumstances are different, and an inclusive hiring process needs to set employees up for success.
"Do you need help with an intranet stipend ... do you have a good camera for your computer, do you need us to send you that webcam - whatever it might be," she said. "Being more understanding that there might be little kids running around in the background, and is that okay. And if it's not okay, how do you work with them to figure it out?"
Wessel believes that on the whole, the virtual hiring environment has provided a path to greater diversity and inclusion. Some of her large clients, she said, such as Unilever and BlackRock, have decided to focus on
"If you want diversity, equity, and inclusion to be a core part of your talent acquisition strategy, focusing more on your virtual strategy than your in-person strategy will do wonders," she said.
- SPC Lifesciences files draft papers with SEBI for IPO
- Sensex rallies 346 pts, Nifty near 17,100 on firm global markets
- Removal of commission caps for insurance agents likely to boost innovation, customer-centricity
- SEBI bans 6 entities from securities market in front running case; impounds ₹2.23 crore
- EazyDiner raises ₹40 crore from DMI Alternative Investment Fund


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Re: Reached 9,000 views. Celebrating with a new Cover!
After reading the forum title I was going to say you should have waited until you got one more view, but you beat me to it. Congrats on the views and the new cover looks great!
Last post by Smuts
Re: How to write more around a 9-to-5?
It helps if you try to dedicate a specific time to it so your brain learns to associate it with that time. Like say you're going to try to write every night from 8-9. It develops a nice habit, and even (...)
Last post by Urban Goat Herder
Re: I am new
Hello there and welcome! The first step on the forums at least is to make sure you put your fiction in your signature so people can get to it easily (Settings > Forums > Edit Signature) There's an easy (...)
Last post by Lack of Poochline
Re: Royal Road Divination
I got 'New World - New Beginning' by Yucatero. Either I'm about to get a new opportunity in life OR I'm going to be hit by a truck and isekaid any moment.
Last post by Sickened Fanfics
Re: My story got featured on Facebook and Twitter of some Royal Road account
Pretty cool indeed. Didn't know that was something that could happen lol.
Last post by Lire
Re: Epic Fantasy?
My book, Fiends For Hire, is a modern fantasy if that's something your open to. Has the rest of your requirements and just hit 1000 pages yesterday.
Last post by jayfiction99
Re: Reached 500 followers
Very impressive! You're killing it. I'm sure you'll reach your goal
Last post by senseiseth
1,000 Pages Posted
Todays upload brought me over the big 1000 for my novel, Fiends For Hire. I'm currently sitting on roughly another 500 pages in backlog too. So if you're interested in a long lighthearted Modern Fantasy (...)
Last post by parkertallan
Re: New Author here
Welcome welcome! This site always needs more comedy so I hope you find a following! Be sure to put your fiction in your signature so people can find it easier. (Settings > Forums > Edit Signature). (...)
Last post by parkertallan
New Covert Art!
Here's the new cover I commissioned for my series, Fiends For Hire. It was done by Fulminaire on twitter. I love it every time I look at it. https://i.imgur.com/c9noZOR.png
Last post by Anodyne
Re: Idea sharing
I think most authors already have MORE than enough of their own ideas, there is no room left in their brains to be stealing ideas off of random posts on the forums! :)) Don't worry about "idea theft" there (...)
Last post by Xian Piete
Re: 1 Volume down, 2 to go!
Holy heck that's quite the achievement! Goodluck with your remaining 2 volumes!
Last post by Kobayashi
Re: Need a few new series to binge.
Hey there! If you have any interest in modern fantasy mine can certainly be binged. It should be breaking 1000 pages tomorrow with a lot more on the way!
Last post by BobCharlie
Re: I need some feedback for my synopsis.
I would say the second is better but the first isn't bad. The last sentence is probably the weakest part of the first so if that got some tweaking the first would be viable too.
Last post by EuRoboto
Re: Reached 500 views!
A solid milestone! It's great you're listening to your feedback and improving. It'll drive the views up that much more.
Last post by TheSpiritInMe
Re: I just hit 50,000 words
Quite impressive. For reference the average novel is ~90k words so you're already over halfway there!
Re: First time reaching 40k views! F yeah!
Congrats! An impressive number indeed! A weird hook and a desire to write can be all you need even if it is originally just a joke.
Re: The Algorithm
Congrats on the early success! You should be sure to put your fiction in your signature so people can find it easier (Settings > Forums > Edit Signature) As for rankings, I'm pretty sure it's entirely (...)
Last post by [Account Deleted]
Re: Just uploaded my first chapter!
Good luck. Everyone has to start someone! Hope people check it out and you get the feedback you're looking for.
Re: First 1000 views!
Congrats! It felt so good when I hit my first thousand so I know how you feel. Keep up the good work and keep climbing!
Last post by realTENSAi