system
Given the following post, respond as if you're commenting on Reddit:
human
Current Master's Program and PI may not be a good fit. What should I do?

Bit of a long one, but I could seriously need some advice from knowledgeable people outside my obviously biased friend group.

Back in the spring of this year, I decided that I wanted to enter a Master's program in Biomedical Engineering to build my skills before doing a PhD. My undergraduate career included a great deal of research but lacked formal experience in synthetic biology and cell therapies which is what I would like to do next, so I thought this would be a good way to prepare myself. I found a professor in Texas at a public university who has experience with the skills I felt I needed (lots of computer modeling, synthetic biology, genome editing, miRNA techniques), and I reached out to him about joining his lab. He told me that I would be a good fit for his lab and that I should apply to the program. He also said that he had all the cells and equipment I would need to pursue my interests and that he was also interested in what I wanted to do my thesis on.

Fast forward a bit, I have been accepted to the program. I am not scheduled to begin classes until the Spring of 2019, but I have already accepted the offer to attend the university. The professor I want to work with (who seems to be the only professor doing systems *and* synthetic biology at the university) has started being more unreliable. He has told me that he wants to meet at least once a month until I actually begin classes (which I was excited about). I have to send several emails to get a single reply usually over a week after my initial email, and he doesn't follow up after meetings/conversations with papers or contact information for people of relevance like he said he would. A few days ago he left the lab early (the guard informed me that he had gone home for the day) despite us having a meeting scheduled to discuss courses I should take, research topics, his recent publications, how methods used in those recent publications could be relevant to my research, potential for collaborations, the list could go on. Needless to say, this was going to be a very important meeting. He then changed his RSVP on Outlook and declined the invitation for the meeting an hour and a half *after* it was supposed to start with no explanation. I took off time from my internship for the meeting, waited for over 30 minutes, and even tried calling the lab phone. I emailed him that night, but still haven't received a reply.

I'm not short on options. My GRE score was high enough to have a shot at most places I've looked, I have a high GPA from undergrad (BS in biochemistry with minors in math and biology), and some pretty extensive research (for an undergrad) and extracurricular activities, plus my current internship at a biotech company. I am rooted in this city for now because I have a house here, so I'm not looking to leave (yet), but there are other schools and a highly ranked Medical Center within driving distance. I have also heard that my company is looking to hire the current interns (including me) after our internship, and it is a real possibility that I would be able to transition into R&D. Then I could go do my PhD somewhere more on the cutting edge for cell therapies, synthetic biology, and/or systems biology.

Okay, so that's the background (Hoping I'm meeting this subreddit's rules on sufficient information). So, now on to what I need to do. Since I was only really interested in going to the school because of the research of that one professor, I wouldn't mind leaving and applying elsewhere. The main questions are "Can I?" and "Should I?"

If I contact the university and try to back out after having accepted my offer for enrollment, will that put a mark of some kind on me for other institutions to see?

Should I back out and apply elsewhere, or am I overreacting? I would hate to work with someone this unreliable, and if he's too busy to handle email correspondence and monthly meetings then how on earth would he handle having another person in his lab?

Edit: removed general location names. Not trying to harm any reputations here.
gpt
Your instincts are spot on. You don’t want to work with this professor. (Ps you should remove your location in this post, that’s pretty identifying.) It sounds like you know what you want to do enough that you could apply straight to PhD programs.