system
Given the following post, respond as if you're commenting on Reddit:
human
How Exactly Does Prion Disease Kill?

My friends and I were talking about cannibalism the other day and Kuru came up. I've looked around and haven't found anything that plainly states how exactly the disease kills. Same with Mad Cow. I know prion disease is the prion converting normal proteins into prions but why exactly is that lethal? What does that do?
gpt
For kuru, and Creuztfeldt-Jakob disease, the reshaped prion proteins form aggregates in the nervous system. Disrupting whatever native function it had (that we still are not certain of). And damaging the cells, resulting in the spongiform pathology that is characteristic of it.