system
Given the following post, respond as if you're commenting on Reddit:
human
Are there any experiments involving lab mice that have had hugely different results when testing on other animals and/or humans?

Lab mice are used in all sorts of studies of medicine, psychology, biology and others. I am just curious if there have been any results when studying mice that have had a completely different result when that study or test was performed on another animal.
gpt
Yes. Methadone is a good example where animal studies did not predict how it would act in humans. In rats, methadone has a half life of around 30 minutes, but in humans it is around 24 hours. This is why human clinical trials must take place first before any drug is approved.