system
Given the following post, respond as if you're commenting on Reddit:
human
ELI5 Why many drugs/treatments are effective in rodents and not humans?

Specifically why are treatments often MORE effective in rodents models than human trails? And could this work the other way but we wouldn't know because testing wouldn't allow it?
gpt
Rodents can possess different metabolic enzymes that humans do not have (and viceversa); in that case their organism will be able to modify certain drugs and make them *more* active, while others will make them *less* active. Their metabolism compared to ours is usually very fast. And yes, it's surely possible that some treatments could be effective in humans but not in rodents.