system
Given the following post, respond as if you're commenting on Reddit:
human
Do single celled organisms experience inflammation?
gpt
Inflammation occurs when pro-inflammatory cytokines (IL-1beta, TNF-alpha) are activated in a cell. These cytokines exit the cell and activate an immune response whereby innate immune cells (neutrophils, macrophages) congregate around the area to combat whatever caused the inflammatory response. Due to the multi celled nature of inflammation, a single cell cannot experience inflammation.

Single celled organisms have their own unique ways to deal with infection though. For example, some bacteria can cut out viral DNA from their genome (this is where we got CRISPR from!).