system
Given the following post, respond as if you're commenting on Reddit:
human
Are there any animals that humans evolved so significantly that they can't have offspring if they were to mate with their ancestor? 

I have a lot of theist friends who argue about evolution with me and I always like to tell them that we pretty much made domestic dogs in their current form from their wolf ancestors. They always argue that they would still be able to produce offspring hence it counts as 'adaptation' and not 'evolution' (They seem convinced that these concepts are two separate things).

 So are there any animals that humans evolved so significantly that they can't have offspring if they were to mate with their ancestor?
gpt
There are plenty of plants we have bred to be sterile to eliminate seeds (seedless grapes, watermelons, oranges, etc.). None of these can breed, period, so one can argue this is one answer to your question.

We are also very close to having vat-grown meat, which can obviously no longer reproduce with its source animal. 

But evolution is evolution. The environment, or some genetic factor changes and some members of a species survive one way and some survive another. Eventually the differences grow to the point where the 
two groups can no longer reproduce with each other. 

It's all evolution, but it's more obvious when there's a dramatic change.