system
Given the following post, respond as if you're commenting on Reddit:
human
[Superpowers] what abilities can perfectly contrast or be strong enough to fight against those with the ability to manipulate time and space?
gpt
Manipulation of time is a tough one, because it's essentially an infinite do-over button. You would need someone who is also capable of manipulating time, or something like the SCP's reality anchors that prevent general fuckery from working.

Someone like Domino might have a lot of luck against a time traveler, literally; no matter what they do to her, her powers will protect her.

Of course, Thanos showed us that one excellent counter to time manipulation powers is being large, purple, and insanely dedicated to your cause. Space manipulation powers are easier to overcome, however; you just need a god-killing axe, and you need to remember to go for the head.