system
Given the following post, respond as if you're commenting on Reddit:
human
[Deadpool] Would it be possible to permakill DP by shoving him into a vat of molecular acid and closing the lid? That seems like something he couldn't come back from.
gpt
Even without a Thanos curse, that acid won't last forever. It'd eat through Deadpool's regeneration, absorbing and combining with the regenerating flesh, until it becomes too weak to affect it. 

You could keep filtering and refreshing the acid. That will effectively *neutralise* him, but still wouldn't *permanently* kill him. "Permanent" implies that you would *stop* the acid bath and he'd still be dead.