system
Given the following post, respond as if you're commenting on Reddit:
human
Why can estrogen be delivered orally via a pill but testosterone cannot?

(I’m a transgender man, and it seems rather odd that trans women can just take a pill and I have to have a shot once a week.)
gpt
It can be, it’s just has extremely poor bioavailability in it’s raw form, so it would have to be alkylated which would make it liver toxic. Hence why most people advise against oral steroids - they have to pass through the liver twice before they reach the bloodstream, which causes cumulative liver damage over time. 

Progesterone (the pill) And esteogen are entirely different hormones.