system
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human
[Star Wars] Palpatine knew of Anikan’s secret marriage to Padme. Had she not died, what was his plan?

Palpatine used Anakin’s love and attachment for Padme to seduce him to the dark side. Padme was still alive after Vader was born through his desire to save her. What if she was saved? Surely the Sith Lord could not allow his apprentice to continue to have such love for another being. Wether or not she left Vader and went into hiding, she would most likely still stand as a call back to the light for Anikan. Did Palpatine have a plan for this? Would he have her killed outright and if so how would he keep this knowledge from Vader? I suspect such an act would be the one thing which could draw enough rage for Vader to be able to defeat the new emperor.
gpt
He'd almost certainly have had her killed. Making it look like an accident could be tricky, although under the right circumstances it could be as simple as sabotaging a medical droid so that its memory is wiped of all information relevant to pre- and post-natal care and psychiatric treatment.

More likely, though, he'd have her obviously murdered, and leave a trail of clues leading back to a faction or individual who he reckons could do with a bit of the old wrath of Vader.

Note that - as we saw in *Attack of the Clones* \- this method doesn't need to succeed; whether Padme lives or dies, the trail of clues will still be there. He can afford to keep arranging assassination attempts until one of them gets through, or until Vader has rage-murdered every single one of his political enemies and he's reduced to pretending the latest would-be killer was hired by that girl who turned him down when he asked her to the homecoming dance in space high school.