system
Given the following post, respond as if you're commenting on Reddit:
human
Why doesn't DNA get tangled inside the nucleus?

We've got about 1.8m of DNA in our nuclei and for most of the time it's not condensed so why isn't it just a single hypercomplex knot like my headphones when I put them into my pocket?
gpt
We actually have enzymes called topoisomerases that prevent our DNA from getting too knotted, by passing strands through each other. Viruses don't have these enzymes, so occasionally when they splort out their DNA, it's knotted.