system
Given the following post, respond as if you're commenting on Reddit:
human
How do we know that Covid-19 vaccines won't teach our immune system to attack our own ACE2 enzymes?

Is there a risk here for developing an autoimmune disorder where we teach our bodies to target molecules that fit our ACE2 receptors (the key molecules, not the receptors, angiotensin, I think it's called) and inadvertently, this creates some cascade which leads to a cycle of really high blood pressure/ immune system inflammation?  Are the coronavirus spikes different enough from our innate enzymes that this risk is really low?


Edit: I added the bit in parentheses, as some ppl thought that I was talking about the receptors themselves, my bad.


Another edit: This is partially coming from a place of already having an autoimmune disorder, I've seen my own body attack cells it isn't supposed to attack.  With the talk of expedited trials, I can't help but be a little worried about outcomes that aren't immediately obvious.
gpt
The SARS-CoV-2 spike protein binds to the ACE2 cell surface protein, but the two structures are completely different. You can think of the ACE2 like a doorknob and the SARS-CoV-2 spike protein like a hand. The normal substrate of ACE2 is angiotensin, which also has a very different structure from the spike protein.

So, there's no risk of the immune system mistaking one for the other. And as others have mentioned, if it did happen, it would have shown up in clinical trials.