system
Given the following post, respond as if you're commenting on Reddit:
human
If an entire species is inbred, how could that be determined or is it not possible unless there's a baseline of the non-inbred version of a species?
gpt
Simplifying a bit - one can count how many genes have multiple variants, and compare that to the total number of genes for the species. 

Variation increases over time by random mutation, but if there is a population bottleneck or inbreeding, it's dictated simply by chance that many variants won't be carried forward.

We know that humans had a big population bottleneck because, compared to species with a similar number of genes (chimps, e.g.), a smaller proportion of our genes have multiple variants.