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human
Will getting the Johnson and Johnson vaccine impact the efficacy of future gene therapy treatments?

Given that the Johnson and Johnson vaccine and many gene therapy treatments both use adenoviruses as a vector, could getting the J&J vaccine limit your options or decrease the efficacy of gene therapy treatments later in life? I was wondering if your body might recognize the gene therapy virus as the J&J vaccine virus and attack it before it can get its job done.
gpt
We don’t know. It’s possible, but it’s more likely that the immune response to the adenovirus vector will be so low, and so short-lived, that it wouldn’t impact subsequent exposure. Remember that the adeno component doesn’t replicate or amplify itself whereas the antigen passenger (spike protein) is driven by a powerful promoter so will be expressed at thousands of time higher than the adeno component, so the latter is probably marginally antigenic. Until J&J or AZ etc publishes details on the response to their adeno carrier we won’t really know. 

In any case even if it does, it’s a minuscule concern. The number of people getting gene therapy is very small, the number getting chimp ad or Ad26 specifically is even smaller if not 0.  It’s not worth worrying about in the general case. If someone is already lined up for gene therapy it might be a consideration on which of the (now multiple choices) vaccines to take, but it’s not something for the general public or even vaccine manufacturers to bother with.