system
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human
[The Callisto Protocol] How the fuck did things get so out of hand?

Seriously. We hear and see before and while the disaster happens that

1. Black Iron is a maximum security prison, and seemingly a fairly brutal one

2. There are armed guards and hilariously deadly robots *everywhere*

The main character, the guy who gets through the whole thing, is seen killing infected left and right. He's seemingly just some random pilot, starting out with just wearing a prison jumper and using a metal stick to beat them to death.

Later on he upgrades to somewhat better equipment, but...those are things that guards *also* have. Presumably in a situation like this they would also have access to better weapons. Yet they somehow got overrun?

The infected are mostly just creepy looking zombies with one or two mutations. More deadly than the regular zombies we'd see in some other outbreaks, sure, but pretty clearly something that someone with weapons and training can handle. *Which we can see in the game, when Jacob beats all of them to a pulp with nothing but a glorified stick.*

Even with SPOILER's intervention, it seems like just locking every door and going through the place with some robots and guns would have solved the whole issue fairly easily.
gpt
1. The Biophage Pathogen was released into Black Iron in secret and without warning, catching the inmates and prison personnel alike off-guard.
2. The Biophage Pathogen spreads *quick*.
3. The Biophage are ridiculously strong and resilient and are capable of completely mutilating and slaughtering normal humans within a split-second. Should even a guard let their... erm- *guard* down, they are going to be *instantly* eviscerated, and with the virus spreading as rapidly and as sporadically as presented, the unprepared prison personnel likely stood no chance. Moreover, the guards may have lacked the survival and combat instincts that Jacob possessed and may have caved the second things went for broke, increasing their chances of being reduced to mincemeat.
4. As seen during the opening chapter of the game, the robot patrollers were all disable, presumably by the Warden, during the beginning phases of the outbreak. Then, upon reactivating, the security bots turned against *everybody* in the prison, barring the Biophage for unknown reasons—presumably the doing of the Warden in an attempt to further his goals—and began gunning down everything that crossed their paths, friend or foe.
5. As the outbreak started, the dense population of Biophage ran rampant about and mauled everything they could find, leaving the guards outmanned and outgunned. However, as things progressed, the population of humans decreased, causing the Biophage to begin spreading out to different parts of the prison, reducing population density, which is why Jacob only encountered Biophage by themselves and in groups of two or three, rarely in groups upward to six, which is *chump change* compared to what everyone else likely had to face all at once.