system
Given the following post, respond as if you're commenting on Reddit:
human
AskScience AMA Series: I am Dr. John Nagy and I'm here to talk about Peto's Paradox and why larger mammals don't have higher cancer rates. Ask Me Anything!

Hello Reddit! I'm a mathematical biologist (@jdnagy96) studying why larger mammals don't have higher cancer rates--like why aren't all blue whales dying of cancer? This is just one of the many questions about cancer that evolutionary theory helps illuminate. We also work on how evolution causes tumors to become malignant and resist treatment. I'll be around in the afternoon (ET), so AMA!
gpt
Hello Dr. Nagy!

Is it possible that the cells of larger mammals have some sort of awareness, maybe through cell signaling, of the size of the tissue they're a part of and are more willing to enter apoptosis since they're more replaceable?

Has there been any study in vitro on cultured tissues? For instance, would 1,000 cells on media have the same cancer rate as 1,000,000 cells or does this phenomenon only occur in the larger context of the animal?

I am a senior Biology major currently taking Biology of Cancer so this is particularly interesting to me. Thanks!