system
Given the following post, respond as if you're commenting on Reddit:
human
[Spiderman] Is there ever a reason given as to why Aunt May and Uncle Ben never had children?

Has this ever been addressed? Why didn't Peter have any cousins? Was Aunt May or Uncle Ben sterile?
gpt
Semi-Doyalist answer here, but there was one notable time Marvel did try to address this with its own story, and it was met with a not very positive reception.

In the early 00's Marvel published a monthly miniseries called "Trouble" which was a contrast to their usual stuff by being a romance/drama set in the 70's.

The story centered on two teen friends May and Mary, who worked at a resort over the summer, and meet two brothers Ben and Richard, who they romantically pair off with. 

To not many people's surprise May and Ben turned out to be Aunt May and Uncle Ben, and Richards and Mary turned out to be Richard and Mary Parker.

The real twist of the story though was that Ben gets May pregnant, but May gives up the baby to Mary and Richard to raise as their own son, because her parents are crazy fundies who would disown her. Which means that Peter was May's biological son all along and ended up back with her eventually.

Marvel and readers pretended this story never happened pretty much as soon as it was written.