system
Given the following post, respond as if you're commenting on Reddit:
human
[Star Trek]Would the Prime Directive apply to a species that evolved from animals taken from Earth?

remember that time the Defiant got thrown back in time and they found the crew's descendants living on an alien planet. 
Suppose something similar to that happened but it was millions of years, instead of  hundreds, and rather than the crews decedents it was their pet's descendants, evolved into sapient beings. 
Would the Prime Directive apply to them?
gpt
It doesn't matter what is the genetic background of a planet's inhabitants. What matters is that the species is sapient, sentient and intelligent, has not previously made contact with an alien civilization that it is aware of, and had not yet developed warp technology.

Hell, even if the species was 100% human, it could still apply if they were sufficiently removed culturally from Earth's civilization, think Star Gate.