system
Given the following post, respond as if you're commenting on Reddit:
human
What is the next major evolutionary change the human race is most likely to undergo?
gpt
In evolution there is nothing "major". There is no intention, direction and purpose. There are random changes that are confirmed or rejected by the natural selection mechanism.

What humans can add to this is their ability to intervene in the natural selection process - by keeping alive and allowing humans to reproduce who otherwise would not survive. So if there is anything "major" it is because of the medical development. Still, nobody can predict at this point what mutations would be confirmed by the aid of the medicine...