system
Given the following post, respond as if you're commenting on Reddit:
human
Are 10G at a centrifuge for 10h the same as 100G for 1h? (in terms of separation etc)
gpt
Ideally the terminal settlement speed of a particle is directly proportional to the centrifugal force acting on it. So, ideally yes. Practically, you'll have diffusion counteracting it more noticeably the slower you spin. So you probably can spin a sample in a benchtop centrifuge until the cows come home and still not get an effect comparable to a fast run in a preparative ultracentrifuge.