system
Given the following post, respond as if you're commenting on Reddit:
human
ELI5: Most antidepressants seem to inhbit (or block) serotonin, dopamine, etc receptors... but if those are what make a person happy, why does blocking them treat depression?

Oh, I'm stupid.  They inhibit reuptake, not the receptors themselves.
gpt
It’s blocking the ‘reuptake’ of them.  Sometimes they don’t get passed on to be used / effective and get reabsorbed back.  So the blockers block that and force them to continue forward making you feel them more.