system
Given the following post, respond as if you're commenting on Reddit:
human
[BATMAN] Which villian, if they died, would create the biggeat powwr vacuum, and/or create the biggest gang war?
gpt
Not in Gotham, but when Ra's Al Ghul seemed to have actually died permanently, the League of Assassins went through a long period of being pulled apart to become loyal to different villains who seized or attempt to seize control of it (Nyssa, Deathstroke, Lady Shiva, Talia). A faction even thought Cassandra Cain was their murder messiah and tried to get her to take them in.

Generally speaking though, the henchmen and footsoldiers in Gotham are already dispersed across a big pool, and any one villain, super or otherwise, disappearing wouldn't be a significant sea change, cause their people would be happy to join up with another crew.

In the 'War Games' story event, a massive power vacuum and gang war of an unprecedented scale occurs, but only after all of the city's major gang leaders are murdered in a single night.