system
Given the following post, respond as if you're commenting on Reddit:
human
Why do lysosomes need a low pH in order to function/degrade proteins?
gpt
Lysosomes need low pH because pH has an effect on protein folding. At neutral pH, the enzymes in lysosomes aren’t folded in a shape to do anything (it is sequestered, active site is being hidden away due to its shape). At low pH, it folds into something that reveals its active site and then can start breaking down stuff. 

This is important because you don’t want the enzymes to be active at neutral pH like the cytosol because it can mess up the cytoplasm.