system
Given the following post, respond as if you're commenting on Reddit:
human
[40K] I know the god emperor of man is technically alive inside the golden throne... But does his mind exist outside the warp?

I mean is there any direct interaction between the golden throne and humanity in this universe?
gpt
The Emperor is capable of it, but such communications are rare, limited only to averting immediate perils to the Imperium as a whole. There's a lot on his plate, and the Imperium can ill afford the consequences from even a minor disruption of his focus. 

I don't think we ever get to see these audiences directly, only their aftermath. When the Ecclesiarchy got a little too big for its armored britches Alicia Dominica, the head of the Adeptas Sororitas, was brought before the throne. Before, she was a fanatical devotee to Gorge Vandire, the Grimdark Pope, but after leaving her audience with the Big E she marched right into Vandire's cathedral fort and chopped his head off, thus ending a religious schism that threatened to topple the Imperium from within.