system
Given the following post, respond as if you're commenting on Reddit:
human
ELI5: Due to the extra chromosome, do people with Down Syndrome only accept blood from other people with Down Syndrome?
gpt
No. Red blood cells don't have chromosomes anyway.

The real problems with blood transfusion has nothing to do with DNA, but usually involves blood types. To give an ELI5 view, blood types refer to ways of classifying blood characteristics. For example, the one most people focus on is the ABO system, which refers to antibodies in the plasma and antigens on the blood cells. If you mix give somebody the wrong blood type, it can be a problem. For example, a person with Blood Type A typically has antibodies specifically against the antigens Blood Type B, so person with Blood Type A identifies these new blood cells as foreign and starts attacking it. Something similar can happen with other blood typing groups, but this (and the Rhesus factor--another antigen that might be on a person's blood cell) is the big one.

Therer are other risks as well, usually when there's something else mixed in the blood. Cytokines are common, which can cause a fever and inflammation, but it's usually pretty mild. There's also occasionally infections or contaminants that can make somebody sick.

But Down Syndome itself doesn't affect blood, donated or received.