system
Given the following post, respond as if you're commenting on Reddit:
human
ELI5: How do antidepressants wind up having the exact opposite of their intention, causing increased risk of suicide ?
gpt
Some people think that antidepressants may work to restore motivation and drive before eventually reaching their full efficacy of restoring overall mood. So for the period that you are feeling more motivated, but still experiencing negative affect, you are more inclined to act upon those negative feelings.

That's a theory anyway. There is so much we don't know about how antidepressants work anyway. We know surprisingly little about what causes depression in the first place, so it's really difficult to work on a treatment.

Hope that helps.