system
Given the following post, respond as if you're commenting on Reddit:
human
If I ate 10,000 calories in one go, would my body be able to digest it all? Or would some of those calories 'pass through' due to my digestive system being overwhelmed?

I get that if I ate an extra 1,000 calories a day, my body would be able to handle those calories and they'd be turned into energy/fat etc. But what if I went crazy and ate 10,000 in one go. Would it affect me in the same way as if I'd eaten 1,000 extra calories each day for 10 days?
gpt
Current microbiologist, future dietitian here:

Yes, some of those calories would "pass through" and not be able to be digested.  Unless your body is used to utilizing a massive amount of calories, it's not going to waste energy having and maintaining receptors in your gut that almost never get used.  For instance, you only make so much bile at a time, which is necessary to absorb fats.  If your gut gets overwhelmed with more fat than you can possibly absorb, it's going to pass through the region where fat is absorbed...which is a relatively short region, and get turned into massive amounts of gas later on down the line.   This gas is the result of microbes in your gut inexpertly fermenting fats, which is a nutrient they are not used to utilizing, so they break it down inefficiently, making gases as their own "poop".  You may absorb some of the other products these microbes create as a result of this breaking down, but it won't be as calorie-rich as if you were able to absorb the fats as fat.

If you consistently eat high calorie foods, or a particular type of nutrient, your gut and its microbiome will change in response to that level of intake, and you would absorb those calories more efficiently.

TL;DR?  The second one.