system
Given the following post, respond as if you're commenting on Reddit:
human
[Friday the 13th] Would a nuke kill Jason for good? What could kill him for good?

Drowning him in acid? Throwing him in an electrolysis machine and letting it break him down to his base atoms?
gpt
Assuming we're talking about Jason X, those sound like the methods needed, assuming the nano machines that constantly regenerate his body are shielded against EMP.

But even that's not a guarantee. 

While Jsson appeared to just be a sturdy mortal when he first started killing, and later an undead resurrected by lightning, but really he was constantly brought back by the dark magic he mother used, years ago. So he could only be killed "for good" by someone of Voorhees blood. Which did happen.

The problem arises that in between getting killed by his niece Jessica, and becoming Jason X, he was brought back from Hell by Freddy Kreuger. 

So, inspite of all hoops you'd have to jump through to drop him for good on the mortal plane, it looks like there will always be a way for him to come back from hell.