system
Given the following post, respond as if you're commenting on Reddit:
human
Why does low testosterone cause depression in men, but the equivalent testosterone level in women and boys doesn't?

Are adult male brains addicted to testosterone or something?  A low T level in men causes depression and lethargy, but what is considered low for a man would be high for a woman or a boy.  How come that level doesn't cause any issues for women and boys?
gpt
This question is fairly pertinent in the transgender community, where it's been pretty well documented (although not necessarily with scientific rigor) that giving a male to female trans person *estrogen will often relieve a lot of the depression and anxiety they had previously felt. 

What has been established is that there are some nuclei in the brain that are sexually dimorphic. Studies have shown that in transsexual women and cissexual women they are similarly sized, but men given estrogen treatment for things like prostate cancer did not so "female" sized nuclei.

Going from that to saying that your neurological sex determines which sex hormones you react positively to and which you react negatively to is a stretch, but is certianly one explanation.