system
Given the following post, respond as if you're commenting on Reddit:
human
Does DNA ever get tangled?

When chromosomes are condensing, does DNA ever get tangled up, preventing the chromosomes from condensing?
gpt
Yes, of course. Like an old phone cable, DNA tends to tangle like hell. There are special enzymes in the cell nucleus called topoisomerases, which basically breaks and rebuilds DNA in specific locations to prevent tangling. (This is more of a ELI 5 version, though.)