system
Given the following post, respond as if you're commenting on Reddit:
human
Can long term use of antidepressants cause epigenetic changes?
gpt
The cause of the disease depression although widely accepted theory of neurotransmitters dysregulation or shortage had been over-simplified. With current studies the effect of use of antidepressants shown to alter the “wiring” system of the neuronal transmissions. In a sense the mass density of the receptors for the neurotransmitters such as serotonin and dopamine starts over-compensating. It does this by either producing higher or lower. Based on the question it will be important to consider what type of antidepressants we are referring to. SSRIs - Selective Serotonin Reuptake inhibitors act either on the pre or post neurones. 
With the concurrent scientific evidence we can say that re-wiring of the neuronal networks of significant neurotransmitters system does lead to a certain level of epigenetical alterations. To what extend this takes place depends upon many variable including baseline receptor density but not limited to this. 
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