system
Given the following post, respond as if you're commenting on Reddit:
human
ELI5: How exactly does overdosing on pills or medicines kill you? What does your body and organs undergo that ultimately cause death?
gpt
This is highly dependent on what a person overdoses on.

If it's opiods like oxycodone or morphine these medications depress respiratory drive. That means a person's breathing slows to the point that they stop and then the heart will stop.

Stimulants like Adderall or meth can cause temperature to rise to the point that organs fail because the proteins in the body (every physical structure in the body is made of proteins and including blood cells, etc) can only work at a certain temperature range. Stimulants can also cause cardiovascular collapse meaning a sudden stoppage of the heart due to it beating to fast, too hard, out of synch, or all three. 

Tylenol causes massive liver damage. NSAIDS like ibuprofen and naproxen cause kidney and liver damage and intestinal bleeding. 

ODing on heart medications will cause your blood pressure to go so low you don't get blood to your brain or the muscle of your heart.

Psychiatric medications can cause cause a change in brain chemicals that can interrupt nervous system function and damnge the liver and kidneys. 

Again, it just depends on the med or illicit drugs.