system
Given the following post, respond as if you're commenting on Reddit:
human
What is happening internally to make weight loss so beneficial? How does losing weight when obese improve health & obesity-related conditions like insulin resistance etc.?

This feels like it should be like, obvious. But for some reason...I don’t REALLY know what happens to a body that loses excess fat. 

How does weight loss improve health? 

Reducing stress on joints makes intuitive sense. But how does weight loss improve insulin sensitivity? How does it improve cholesterol? How does it improve blood pressure? 

Is it losing fat that does that, or simply eating less? 

Etc. 

Hope this question makes sense. I’m on a journey to lose 100lbs and wondering what’s happening inside o me to make me healthier (I hope!)
gpt
Hi, PhD student here. Excess fat in adipose tissue stresses out the cells. When they have too much lipid in them, they release cytokines. Sometimes they burst and call in macrophages to remove the debris, also releasing cytokines. This becomes systemic and you have a constant low grade inflammation throughout your body. Over time, this constant inflammation interferes with insulin signalling (Insulin signalling is what controls your blood sugar and is very important in preventing diabetes). It prevents proper activation of a key signal transduction protein called IRS-1 and also interferes indirectly in downstream processes. This is why you are more likely to get diabetes when you're obese. Your liver is one of the key organs affected by insulin . When your signalling goes wonky, the excess fatty acids from your diet and the fat you make through lipogenesis either gets stored in your liver, giving you steatosis (or a fatty liver) or gets exported into the blood stream through the use of very low density lipoproteins (or V-LDL or the "bad" fat). This LDL is small and can stick to the insides of your arteries, giving you high blood pressure or artherosclerosis, putting you at risk for a cardiac event. If you have diabetes, this is even worse as the constant high blood sugar damages the heart tissue making you less likely to survive the attack. When you treat the obesity early enough, you can heal the damage and have a much better quality of life.