system
Given the following post, respond as if you're commenting on Reddit:
human
[Star Wars] Darth Sidious decides to give the Separatists a clone army and the Republic a Droid army. How are things different?

Would the war be vastly different? Would Order 66 have been successful?
gpt
The only difference would have been the way the Jedi were exterminated. Part of the reason the Republic was given clones was so the Jedi could form bonds with their soldiers. Become friends and allies, comrades and respected friends, and they would never suspect the blaster in the back. Plus, the idea of fighting alongside literal slave soldiers helped keep the force and its need to be balanced muddy and off-base. The Jedi had to constantly wrestle with the fact that their most trusted wartime comrades had no freedom or choice. 

If the Republic had used droids, the Jedi would have not formed such bonds, or been so conflicted over their role. HOWEVER, they would be upset about their need to kill living beings in order to preserve the Republic. 

It's likely that far more Jedi would have fallen to the dark side if they were forced to kill clones. Clones with thoughts, feelings and fears. These dark jedi could turn on their former Jedi brethren, and the order could have torn itself apart. 

HOWEVER, even though the idea of converting so many Jedi to the dark side seems nice for a Sith lord, it presents the same problems that plagued the old sith order. Factions would have erupted, infighting would have been rampant, and more than a few Jedi who clung to the light would have gone deeper into hiding than they otherwise would. Palpatine would have had to deal with dozens, maybe hundreds, of rivals who wanted to exercise their new dark powers. They wouldn't have been Sith, but they would still be just as awful and annoying. Plus, he would have had little ability to directly control them like he directed the course of the war itself. That could have created far more problems than it solved.