system
Given the following post, respond as if you're commenting on Reddit:
human
[Marvel] How much damage could a fully unhinged-out-for-blood-no-holding-back Spider-Man do?

Spider-Man is always holding back, he’s careful to stop his enemies but never kill them. I’m just curious how dangerous a “fuck it you’re all going down permanently” 616 Spider-Man would be. 

How much effort would it take to stop him. Who would stand the best chance?
gpt
In the elseworlds story *Marvel Universe vs The Punisher,* a rage-virus is released that turns everyone who gets infected into a sadistic, amoral cannibal, who maintain all of their mental capacity as far as tactics, strategy and the like are concerned. Spidey is the first hero to be publicly infected.

After five years of carnage, Zombie Spider-man is one of the only two A-listed infected heroes left in New York, by virtue of his combination of hit-and-run tactics and his utter willingness to just take your head off with the first blow. His Spider-sense prevents the handful of uninfected heroes from pinning him down, he's able to strategically web up sections of the city to make them impassible to anyone but him, and he just generally turns New York into his personal bastard playground until zombie Kingpin shows up with a large enough army of infected superhumans that he can't take them all directly.