system
Given the following post, respond as if you're commenting on Reddit:
human
ELI5: what happens with a donor organ's DNA after a successful transplant?

My assumption is that over time the organ regenerates new cells with the host's DNA. Or do the two stay distinct for life, or do they merge into a mix of the two? If they stay separate, is there a definite boundary, and does the host's future offspring bear the DNA of three bloodlines instead of two?
gpt
The host cells keep the host's DNA and the implanted organ's cells keep the donor's DNA, and certainly possible future offspring will have the host's DNA only. They do not mix, the host cannot regenerate cells he does not have anymore only the organ itself can regenerate those cells (if it can regenerate), the host actually has immunosuppressants for the rest of his life so his immune system does not destroy the implanted organ.