system
Given the following post, respond as if you're commenting on Reddit:
human
[Roger Rabbit] alcohol makes Roger go bat shit nuts. But, we see other toons like Hank Hill and Rick Sanchez drinking all the time (in Rick’s case, absolutely smashed!). If we assumed that Rick and Homer exist in this universe, would they react the same way, or are they more immune?
gpt
They're both going for different kinds of humor. That's actually the explanation; we see a couple times that a toon's behavior is totally informed by their... for want of a better word, their routine. So some toons are the type to melt when they're embarrassed, turn completely pale when terrified, reach into pockets that weren't there before and pull out something that couldn't possibly fit in there... et cetera. And some of them aren't. 

I would assume the guys you're talking about find lodgings in Cool World.