system
Given the following post, respond as if you're commenting on Reddit:
human
Medically speaking, what is the difference between an elevated heart rate from drugs vs exercise?

If a heart rate is 110 from walking versus 110 from an adrenergic drug, what differences will there be? Is stroke volume vastly different? Does that affect peripheral vessels at all? Does the heart suffer any sort of damage from the drug compared to the exercise? Is it strengthened similarly?
gpt
Physical exercise releases many chemical processes that affect the muscles and blood vessels, usually making vessels more elastic while muscle tissue fills with blood. This entire process causes the heart rate to increase to compensate and keep blood flowing fast enough for adequate circulation and respiration. 

Increased heart rate from a drug isn't going to have the system wide effects of exercise, so the increase in heart rate and blood pressure isn't being compensated by the physical effects of exercise. This is usually detrimental because the increased pressure without elasticity of exercise in the vessels leads to other problems like stroke, heart attacks, and atherosclerosis over time.