system
Given the following post, respond as if you're commenting on Reddit:
human
ELI5: How do Tylenol and Advil destroy your liver?

Edit: No I didn't ~~watch~~ listen to This American Life the other day. I was having an argument with a friend about the effects of Tylenol and Advil. 

Edit: Thank you for all the great responses! I get it now.
gpt
Tylenol is acetaminophen.

Your liver metabolizes acetaminophen.  The metabolite of acetaminophen is toxic to the liver.  It destroys proteins and DNA in the liver. However, there is a compound in the liver that quickly neutralizes this harmful metabolite to something that isn't harmful.  Too much tylenol overwhelms this compound.  So of course the treatment for an overdose of tylenol is to give the compound that neutralizes the harmful metabolite of acetaminophen.

Advil is ibuprofen.  Ibuprofen nor it's metabolites destroy your liver.  It will affect your kidneys before your liver.