system
Given the following post, respond as if you're commenting on Reddit:
human
[Mass Effect] CMV: Using the genophage on the Krogan was the best possible solution and a cure should not be found.

The Krogan are unable to monitor their own reproductive rate. If left unchecked the Krogan will use up all the resources available to them before moving on to the next planet or population center. 

The genophage doesnt even render them sterile it just returns their reproductive rate to that of their pre-industrial society. If the Krogans wanted to they could repopulate and have a net positive population growth but they would rather kill each other and fight amongst themselves.
gpt
The mistake was the uplifting. They essentially tried to integrate a primitive species into a hyper-advanced space community.

The Krogan's never had the chance to properly develop into an equal partner so they just did what they had always done. Wage war.

With several centuries gone past and an bonding experience with the rest of the galaxy (fighting the Reapers) it stands to reason that the integration process will be much smoother this time around. And remember, with Eve there is a factor in Krogan politics that has never been there before. 

And there is enough space in the galaxy, there aren't that many relevant species but literally billions of stars.