system
Given the following post, respond as if you're commenting on Reddit:
human
[Chemistry] Helium has a higher 1st ionization energy than any other neutral atom. Is it possible to create a compound which is more difficult to remove an electron from?

Helium's ionization energy is about 2370 kJ/mol which is higher than any other element's and is also higher than all bond energies (that I know of). However, is it possible to create some neutral compound which is harder to remove an electron from? I'm thinking teflon or some sort of fullerene would come closest but I'm not sure.
gpt
i don't think that's possible. the ionization energy of helium is so high because it has two electrons closest to the core and two protons in the core. every electron you add will be on an outer shell and therefore easier to ionize. molecules have lower ionization energies in general because of the very same reason, except for H2
maybe. 

However you can get higher ionization potentials by preliminary ionizing the matter :)