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human
Need help please ;_;

Hello everyone, I'm going to make this short and sweet. I defended my M.S. last October (Hurray!) and am now working on my Ph.D., my advisor wanted to publish my M.S. work, so I was re-reading all of my gels/charts etc. when I notice that I made a HUGE mistake, the numbers from my results don't add up to my samples. Essentially, my entire thesis is WRONG, but I obviously want to publish what's right, so how do I tell my PI that my M.S. was basically wrong and that I've fucked up royally? (I wasn't exactly the best M.S. student either, so I feel really bad telling him this too) I feel so stupid for overlooking these large mistakes for so long! I think I just need to take a break from research in general, I'm starting to feel too overwhelmed.

I've already given speeches at conferences etc. so I'll essentially be contradicting myself when I speak again. I feel so stupid and depressed, I guess with the hustle and bustle attitude of grad school, I became too busy and sloppy with my work. The good news is I haven't published anything in journals, so I have that going for me.

Will I have to "re-defend" my thesis? How bad is this going to affect me? I would never intentionally include wrong data in my work. Has anyone out there been through similar experiences, I could really use any help/words ;_;
gpt
First of all, you need to tell you'll advisor. Not telling them is probably the worst move. Second of all, mistakes happen. You shouldn't feel too bad. People publish corrections to journal articles when they realize they made mistakes or have more information about the results. 

So start this conversation with your advisor sooner rather than later.