system
Given the following post, respond as if you're commenting on Reddit:
human
How and why does the human body develop a tolerance for drugs and/or alcohol? Do other species do this?
gpt
The reason is different for every type of drug.  For alcohol, the body starts producing more of the enzyme that breaks alcohol down so as to remove the poison more quickly; for opiates, the brain starts to reduce it's own production of related neurotransmitters to adjust for the over-activity from the drugs; and so forth.  Each drug will have a slightly different mechanism, but they're generally all a form of bio-feedback where the body tries to compensate for the effects of the drug by up- or down-regulating some metabolic or neurological process.