system
Given the following post, respond as if you're commenting on Reddit:
human
ELI5: Why does your body's immunity tank with sleep deprivation?
gpt
When you don't get enough sleep there is a decrease in the number of T cells (major player in the immune system) and an increase in the factors that cause inflammation. Inflammation without reason can lead to tissue damage, which also makes it easier for pathogens to start an infection because part of your immune system will be concerned with damage and not so much with other areas of the body. T cells along with a lot of other proteins and hormones are made while you sleep, and if you don't sleep long enough you will not have made enough of these cells and molecules.