system
Given the following post, respond as if you're commenting on Reddit:
human
How does the single human prion protein (PrP) cause a number of different diseases (vCJD, fatal insomnia, kuru, etc) as it changes from PrP(C) to PrP(Sc)?

As far as I can tell, the protein is the same (both in terms of the normal and disease-causing isoforms), and the mechanism is the same (misfolded protein converts normal protein in a chain reaction that leads to protease-resistant plaques). So why are there a number of related but distinct diseases associated with the human/mammalian prion protein?
gpt
The differences in disease symptoms and pathologies are likely a product of where in the brain the prion originates and thus how it spreads. Basically what parts of the brain it damages and in what order.

Other than that vague answer we don’t really know but, as everyone else is saying, if you work it out there may be a Nobel prize on your way!