system
Given the following post, respond as if you're commenting on Reddit:
human
Eli5: What happens in the brain when we feel guilt-tripped?
gpt
Your brain lets loose some angry juice up there. Because you feel the social contract has been broken and you've been abused. You cause a mess and that encourages others to not do that.

Or, did you mean, when you feel guilt? 

Your brain lets loose the sad juice. Because humans are social animals and we do something that harms our society, a normal healthy brain will disincentivize that action.   Offer not available for psychopaths.