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human
[Star Wars] Would R2-D2 have been able to kill Anakin in the period between the massacre of the Younglings and the duel on Mustafar?

In canon it seems that Artoo was unaware of the massacre before the trip to Mustafar. In this scenario let's assume that by accident, he was there to witness it without Anakin knowing he was there.

1. Given Artoo's known erratic behavior and lack of memory wipes, would he be able to hyperspace jump their starfighter into a star or planet and take out his insane master? 

2. How quickly would Anakin figure out what was happening and would he be able to reverse it in time? 

3. With Grievous dead, who dispatches the Confederate leaders on Mustafar? Do they just scramble away once they hear about the emperor and Order 66?
gpt
Yes. 

R2-D2 can just remove the safety systems in place to prevent Hyperspace collisions (that which pulls a ship out of Hyperspace when it detects mass ahead of it). Remove that, a degree off center and then they can hit something in the way that basically ends them instantly ala what happens with the First Order fleet.

There is a reason why Hyperspace Lanes exist, space has stuff inside of everywhere and the lanes are basically mapped routes that are clear of debris like asteroids and the like.

Hyperspace lane mappers are super rich since they can sell these routes for massive amounts of cash, each one is a shortcut through a road with metaphorical roadblocks every 10 meters (or mines if you have no safeties) that never existed before that point.

Which means that deviating slightly from it, a single degree over light years of space? That's going to be dangerous given the distances they are travelling at. 

Anakin wouldnt have any idea at all while it was happening. Unless R2D2 turns the ship by himself and aims directly at a planet or something. 

As for the Confederate leaders... well they would be able to run the hell away. No Anakin to cut them down like wheat before the scythe, no clone ships, nothing that was able to get in there since they were waiting to meet Sidious' representative. They see clones or mercenaries and they are running the hell away and the war continues, assuming that Sidious is betraying them. 

Anakin heads in on his own, they see a little ship, they think that things are kind of nice and great and that's fine since what could one man do right? A larger ship with a presumably larger contingent of clones or mercenaries? That tips off all their alarms. 

Basically with Anakin dead the war continues on and Palpatine... well he's got a lot of egg on his face and if they release the information on what he did it might cripple his political ambitions.

Then again he does own the clones so things might just work out for him anyway.