system
Given the following post, respond as if you're commenting on Reddit:
human
[Star Wars] What is the difference between the Emperor's Hands and the Inquisitors? Don't they kind of do the same thing?
gpt
The Inquisitors were an organization whose primary focus was location and elimination of surviving Jedi, with a secondary focus in intelligence-gathering and interrogation. Although they had fingers in other pies, these were their foremost objectives.

Emperor's Hands, on the other... er, hand, were general-use operatives to carry out widely-varying objectives under Palpatine's rule. They also generally avoided using strong dark-side powers, perhaps to avoid being noticed or developing independent streaks dark side users often did. This stood in stark contrast to the Inquisitors, who actively encouraged their members (many former Jedi) to fall to the dark side.

That last bit is also important, as the Emperor's Hands' greatest asset to Palpatine was their loyalty. While the Inquisition was numerous and powerful, the Hands' loyalty was unshakable as long as Palpatine was alive.