system
Given the following post, respond as if you're commenting on Reddit:
human
ELI5: How do painkillers stop the pain?
gpt
So certain medications such as acetaminophen(commonly found in cold medicine) blocks certain receptors such as COX 1/2 in your body. These receptors are responsible for you feeling pain. By blocking these receptors, the pain response cannot bind to those receptors. The pain is still there, you're just not experiencing it because there is no perception of it. Let me know if you have any questions.