system
Given the following post, respond as if you're commenting on Reddit:
human
ELI5:How did they figure out what part of the blowfish is safe to eat?

How many people had to die to figure out that one tiny part was safe, but the rest was poison? Does anyone else think that seems insane? For that matter, who was the first guy to look at an artichoke and think "Yep. That's going in my mouth."?

Edit: Holy crap! Front page for this?! Wow! Thanks for all the answers, folks! Now we just have to figure out what was going on with the guy who first dug a potato out of the ground and thought "This dirt clod looks tasty!".
gpt
Well, you've got a bit backwards. A small portion is dangerous, and most of it is safe. If it were nearly all poisonous, it probably would never have become a food. 

 The dangerous part contains a chemical which is so fast acting that you can feel its effects on you within seconds after touching it to your tongue. So it's not that hard to figure out which part contains the poison.