system
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human
[Doctor Strange in the multiverse of madness] Does the MCU take place in a diffrent multiverse?

The majority if not all of Marvel projects take place in the same multiverse, some of the animated series even have official designations, the MCU included, it being Earth-199999. But now it's being refered to as Earth-616, which is the name of the mainline comic universe.

First, it was refered with that number by Mysterio in Far From Home, but fine, Mysterio wasn’t actually from a different universe, and it was probably some bs he came up with. But now, in Multiverse of Madness, Christine Palmer of Earth-838 refers to the MCU as Earth-616.

There's also the fact that América Chavez says she is the only one of herself in the Multiverse, due to never dreaming, since dreams are windows to other universe.

So has is the MCU still a part of the same multiverse as the comics, or is it from a different one in it's entirely?
gpt
It seems likely that it is a different multiverse, yes- the existence of different multiverses is canon in the Marvel Universe, and it seems fundamental cosmic things like the Dark Dimension, the Cosmic Entities, Asgard, the Infinity Gems, the laws of multiversal travel and so forth are all different as well as more "small scale" changes.

If we want to speculate, it might be a "meta multiverse"- just as a multiverse contains countless different versions of one universe, perhaps there's a higher structure containing countless different versions of the one multiverse. Earth-616-B in multiverse-b. Or maybe it's just a freakishly similar multiverse. Either way, yeah, it's pretty definitively a different multiverse now.