system
Given the following post, respond as if you're commenting on Reddit:
human
Why does Grapefruit have an adverse reaction with many medicines / drugs?
gpt
One of the major metabolizing enzymes of the liver is cytochrome P450. Grapefruit juice contains a compound called Furanocoumarins. This compound inhibits cytochrome p450. When Cyp450 is inhibited the bioavailability of drugs that are typically processed by that enzyme dramatically increase. This can be very dangerous if the level of drug now reaches toxic concentrations.