system
Given the following post, respond as if you're commenting on Reddit:
human
Does a ketogenic diet can affect the half-life of a liposoluble drug?
gpt
No, it does not.

Liposoluble drugs *may* accumulate in body fat if they're present in excess, however, the speed at which they break down isn't affected by how many ketone bodies are present in the system, as when the drug is being broken down, it's not in the body fat yet.

When the excess is stored in body fat, then it's released as the fat cells break down and this is dependent on how many ketone bodies are present, yes, but not solely on this fact. If you take in enough nutritional fat, your ketones will prefer to break down the nutritional fat.

TL;DR: No.