system
Given the following post, respond as if you're commenting on Reddit:
human
ELI5: How do we know we haven't found a groundbreaking cure for a disease yet, and that it simply doesn't work on mice?
gpt
We don't, also mouse models are pretty bad for finding treatment depending on who is making the claim the failure rate for drugs that work in mice dont work in humans 70-95% of the time. Given this it seems likely a substance tested on  mice that failed would work in humans, the problem is human testing is far more difficult than mouse testing not only due to ethics but also you cant engineer a human to have diseases you want to test.