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Genomic Signals for the Study of Multiresistance Mutations in M Tuberculosis

The genomic signal analysis of nucleotide sequences reveals features difficult to identify using only the symbolic representation in the genomic data bases. Some genomic signal features correlate well with functional features at phenotype level. The paper presents results of GSA applied in the study of Mycobacterium tuberculosis rpoB gene mutations known to confer rifampin resistance.