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Pyoderma Gangrenosum in Infants and Children

Abstract: Pyoderma gangrenosum is an uncommon ulcerative skin disorder that occurs in all age groups. Approximately 4% of patients are infants and children. There are several notable differences between the childhood and adult manifestations of the disease, including the distribution of lesions and associated disorders. We reviewed the childhood cases (≤18 yrs of age) of unequivocal pyoderma gangronosum in the English literature and tabulated the trends in clinical features, associated disorders, and therapy. We report our 3‐week‐old patient, the youngest documented case. Of the 46 patients, only 4 were less than 1 year of age. A systemic Illness was present in 74% of the older children, most commonly, ulcerative colitis. Only one Infant had an associated problem (HIV+) at the time of onset. Infants appear to have an unusual distribution of perianal and genital lesions not often described in other age groups. Our review suggests that pyoderma gangrenosum in children has a similar clinical appearance to that in adults. It Is associated with some of the same underlying disorders, but with different frequencies. The distribution of lesions in children Is similar, often involving the lower extremities, but pyoderma gangrenosum of the head and face appears to be more common in children. Infants may have ulcers in genital and perianal areas. The most frequently prescribed treatment for children is systemic corticosteroids, which generally are very effective.