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The effects of suprofen in rats with implanted cotton pellets.

Implanted cotton pellets with closely adherent granuloma tissue were removed from rats treated orally during 7 consecutive days with solvent or 2.5, 5.0, 10, 20 or 40 mg/kg of alpha-methyl-4-(2-thienylcarbonyl)benzeneacetic acid (suprofen) by gavage. Highly significant decrease (P less than 0.001) of the total cotton pellet dry weight was observed in the groups given 5.0 mg/kg of suprofen or more. The pronounced activity on total cotton pellet weight was obtained without any effect on body weight gain, on food consumption or on the weight of thymus and adrenal glands in the same animals. We conclude that a maximal effect against the proliferative phase of inflammation is obtained with 10 mg/dg of suprofen, in the absence of any steroid-like or toxic side-effect.