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Broad-Based Molecular Methods for Viral Discovery, Diagnosis

A disease outbreak in 2007 on Yap, an island in Micronesia, “looked a lot like Dengue,” says Robert Lanciotti of the Arbovirus Diseases Branch of the Centers for Disease Control and Prevention (CDC) in Fort Collins, Colo. However, a pan-flavivurus array-based analysis of samples revealed that it was not dengue but a Zika virus. “The only prominent thing about Zika is that it is at the end of the list of viruses in the flavivirus family. It had never before been associated with a human epidemic,” he says. “That's a good justification for these broad-based chips.”