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Cerebral volume measurements and subcortical white matter lesions and short‐term treatment response in late life depression

Late life depression is associated with volumetric reductions of gray matter and increased prevalence of subcortical white matter lesions. Previous studies have shown a poorer treatment outcome in those with more severe structural brain abnormalities. In this study, quantitative and semi‐quantitative magnetic resonance imaging (MRI) measures were studied in relation to response to a 12‐week controlled antidepressant monotherapy trial.