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Long survival in metastatic rectal cancer: Due to modulation of the microenvironment?

2 cases of patients with remarkable survival time in stage IV rectal cancer are presented. Histopathological data attributable to malignant tissues may deliver possible reasons for the favorable course. Arguments to acknowledge the value of the modulation of the intra- and peritumoral microenvironment in the treatment of metastatic dieases are presented.