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[The role of cytokines in pathogenesis of nonspecific ulcerative colitis].

Etiology of nonspecific ulcerous colitis (NSUC) as well as its pathogenetic mechanisms remain obscure. Cytokines are presently shown to play an essential role in development of inflammation. Cytokines are produced by the cells in the inflammatory infiltrate in NSUC, therefore, changes of their level in the blood and biopsies from colon mucosa is naturally determined. Current investigations register various changes in the levels of both proinflammatory and antiinflammatory cytokines. Further studies of unknown mechanisms of cytokines action may contribute to design of new methods of NSUC management.