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Single-molecule DNA hybridization on nanoporous gold nanoparticle array chip

DNA hybridization, where two single-stranded DNA molecules form duplex through sequence-specific interactions, is a fundamental biological process. To gain better understanding, sequence-specific detection of hybridization at the singlemolecule level has been instrumental and can find a wide variety of applications. Nanoporous gold nanoparticle (NPGNP) array chip features large specific surface area and high-density plasmonic field enhancement known as “hot-spots” that are attractive in nanoplasmonic sensor development. In this paper, we discuss results on detecting single-molecule DNA hybridization on functionalizing NPG-NP array chip with unique bio-recognition elements towards both high sensitivity and specificity.