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Morphologic changes in white and brown adipose tissue by insulin, thyroxin and cortisol in organ culture

In order to compare the morphologic response of white and brown fat to various hormones in vitro the technique of organ culture was used in this study. Explants of white and brown fat from young mice fasted for 48 hours were exposed to culture media supplemented with insulin, thyroxin or cortisol. Morphologic changes due to these hormones were studied by means of histologic analyses and cell width measurements. Insulin acted to increase the size of cells and intracellular lipid content of brown and white fat explants when compared to similar explants exposed to unsupplemented media. Brown fat explants reacted earlier than white fat in this case. Thyroxin or cortisol alone had no influence on cell width or intracellular lipid content of these tissues. With the combination of insulin and thyroxin only white fat cells showed a greater increase in lipid deposition than that seen with insulin alone. No significant changes were noted when the combination of insulin and cortisol, or when all three hormones were added to the culture medium compared to that seen with insulin alone. The conclusion reached confirms those of other authors that brown and white fat possess enough dissimilarities to be classified as two different types of tissue.