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Assessment of Dynamic Image Analysis as a Surrogate Dissolution Test for a Coated Multiparticulate Product

Dynamic image analysis (DIA) was used to measure particle diameter (D50) of in—process samples removed during fluid bed coating. A single, rapid measurement gave D50 to within 4 μm. Samples removed at intervals of 2% weight gain were readily distinguishable by DIA and by their drug release profiles. Drug release was related to D50. DIA was assessed as a surrogate dissolution test with considerable potential. Current limitations of the approach were presented.