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Connexin‐43 and aquaporin‐4 are markers of ageing‐related tau astrogliopathy (ARTAG)‐related astroglial response

Ageing‐related tau astrogliopathy (ARTAG) appears in subependymal, subpial, perivascular, white matter (WM) and grey matter (GM) locations. Physical effects, blood–brain barrier dysfunction and blood‐ or vessel‐related factors have been considered as aetiology. As connexin‐43 (Cx43) and aquaporin‐4 (AQP4) are related to these, we hypothesized that their immunoreactivity (IR) varies with ARTAG in a location‐specific manner.