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Genes and mutations involved in the resistance of chlamydia species to antibiotics: a literature review

Chlamydiae are intracellular bacteria responsible for various diseases in human and animals. The treatment of chlamydia infections with antibiotics may induce resistance of a number of strains of chlamydia. In our work, we analyzed a set of data related to work describing genes mutations responsible for the mechanism of resistance. We performed a comprehensive literature search in various databases (PubMed, Google Scholar, Cochrane library) using specific terms and keywords. In addition, we hand-searched the reference lists of identified papers. As a result, we have found a list of mutations in 23S rRNA, 16s rRNA, L4, L22 and rpoB genes, sorted by species and antibiotics. These results and knowledge of these genes and mutations will help to perform further investigations to understand mechanisms of resistance and to improve the treatment of this infection.