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Curcumin inhibits reactive oxygen species formation and vascular hyperpermeability following haemorrhagic shock

1. Oxidative stress induced by reactive oxygen species (ROS) is a key mediator of haemorrhagic shock (HS)‐induced vascular hyperpermeability. In the present study, curcumin, a natural anti‐oxidant obtained from turmeric (Curcuma longa), was tested against HS‐induced hyperpermeability and associated ROS formation in rat mesenteric post‐capillary venules in vivo and in rat lung microvascular endothelial cells (RLMEC) in vitro.