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Distribution of Centromeric Proteins and PARP‐1 during Mitosis and Apoptosis

A large complex of proteins, called CENPs, are associated with centromeric DNA. Some of them exhibit a cell cycle‐related expression (e.g., CENP‐E and ‐F) and are required for the transition from interphase to mitosis, whereas constitutive proteins (e.g., CENP‐A, ‐B, ‐C, ‐G, and ‐H) reside permanently at the centromere and are essential for the correct kinetochore assembly. Poly(ADP‐ribose) polymerase‐1 (PARP‐1), which plays an active role in many basic processes, was described as a possible regulator of CENPs. By multicolor immunofluorescence we therefore analyzed the distribution of PARP‐1 and its interaction with CENP‐B, ‐E, and ‐F during mitosis and apoptosis.