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Plasmodium berghei‐specific T cells respond to non‐processed sporozoites presented by B cells

The mechanism of malaria protective immunity induced by immunization with radiation‐attenuated Plasmodium sporozoites (SPZ) is only partially understood. For example, B and T cell responses specific for the circumsporozoite (CS) protein, a 46 kDa SPZ surface protein, have been characterized; however, events leading to SPZ‐specific T cell activation, i.e., processing and presentation of SPZ by antigen‐presenting cells have not been investigated. In the present study we describe the in vitro analysis of requirements for accessory cell function in the presentation of SPZ to SPZ‐immune T cells. The results establish that SPZ‐induced proliferative T cells are reactive to non‐processed SPZ presented by activated B cells and, thus, imply that the non‐processed form of the SPZ‐associated CS protein restricts the induction of the potential CS protein T cell repertoire.