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Single layered small intestinal submucosa in the repair of severe chordee and complicated hypospadias.

PURPOSE
Severe ventral chordee often accompanies proximal hypospadias. We describe our experience with single layered small intestinal submucosa (SIS), a commercially available, acellular, collagen based biomaterial, in the repair of severe chordee as part of a multistage approach to the repair of proximal hypospadias.


MATERIALS AND METHODS
Between 2001 and 2002, 9 boys with proximal hypospadias (penoscrotal to perineal) and severe ventral chordee (greater than 40 degrees) underwent SIS grafting to correct the curvature. In each case the urethral plate was transected at the point of maximal curvature, the defect in the corporal bodies was measured, and the SIS graft was cut 2 mm wider around the perimeter of the defect and sutured into place. Skin resurfacing of the ventral penis was performed in standard fashion using Byars flaps. Recurrence of chordee was assessed by an artificial penile erection test at the time of stage 2 reconstruction.


RESULTS
Of the 9 boys 8 underwent a planned 2-stage repair with subsequent urethroplasty 6 to 12 months after the initial stage 1 chordee repair. Median age at stage 1 repair of the 8 boys was 9 months. Native meatus location was penoscrotal in 6 boys, mid scrotal in 1 and perineal in 1. A 14 month-old boy underwent 1-stage chordee correction with SIS and a transverse preputial island tube graft urethroplasty for penoscrotal hypospadias. There were no perioperative medical or surgical complications related to use of SIS for chordee repair. Median age of the 8 boys at stage 2 repair was 18 months. At stage 2 the graft site was supple and smooth without significant scarring. All chordee correction has remained durable with followup ranging from 16 to 21 months. Postoperative complications occurred in 3 cases, including meatal stenosis requiring meatoplasty, subcoronal fistula requiring repair and complete breakdown of the neourethra in the single stage repair case.


CONCLUSIONS
Although this study includes a small population of patients and has limited followup, our favorable experience with single layer SIS suggests that it is a safe and effective, commercially available material for corporal body grafting to correct severe chordee as part of a multistage surgical approach to repair complex hypospadias. A larger series of patients with longer followup is necessary to determine if the chordee correction remains durable. Our experience is insufficient to judge its efficacy in single stage repairs.