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Non-viral Transfer of Sox-trio Gene to Adipose Tissue-Derived Mesenchymal Stem Cells Using a Microporator

Introduction The adipose tissue has attracted attention on account of its easy accessibility and abundance. It has been reported that adipose tissue-derived mesenchymal stem cells (ATMSCs) obtained from lipoaspirates have the multilineage potential to differentiate into adipogenic, chondrogenic, myogenic and osteogenic cells. Since the pioneering studies demonstrated chondrogenic differentiation from ATMSCs subsequent investigations including one from the authors’ group did not achieve comparable results using the combination of growth factors currently known to induce chondrogenesis from BMMSCs. Many lines of evidence, both in vitro and in vivo, have shown that SOX(sex determining region Y-type high mobility group box) proteins are necessary for chondrogenesis. This study tested the hypothesis that sox-trios(sox-5,6,9) enhance chondrogenesis and suppress hypertrophic changes during chondrogenesis from ATMSCs(adipose tissue derived mesenchymal stem cells).