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Intra-articular thio-tepa compared with depomedrol and procaine in the treatment of arthritis.

A double-blind comparison of intra-articular Thio-tepa, Depo-medrol, and procaine was performed in thirty-nine patients with inflammatory arthritis. Thio-tepa demonstrated a slight superiority, but the potential adverse systemic effects of the drug may not warrant its use. However, no such effects were noted in this study despite a dose of sixty milligrams. Medical synovectomy was not a demonstrable result of this treatment.