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Serum Copper Levels and Epilepsy

Serum copper levels of 94 epileptic children and 80 adult patients were determined. The children were divided in two age groups, 8–12 and 12–17 years. The adult patients (17–40 years) were divided according to sex. Serum copper levels of the different patient groups were significantly higher than in normals. Patients were also classified by the International Classification of Gastaut et al. All types of epilepsy showed the elevated serum copper levels. Three possible explanations are discussed, viz. a nonspecific effect of stress or muscular activity during the seizures, a medication effect and a possible relation to the illness itself. There seems to be some support for the latter hypothesis.