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[Evaluation of cerebrospinal fluid and plasma neuron-specific enolase (NSE) concentration in patients with purulent, bacterial meningoencephalitis].

The aim of the study was evaluation of usefulness of cerebrospinal fluid (CSF) neuron--specific enolase (NSE) concentration assessment in diagnostics of purulent, bacterial meningoencephalitis in adults. The investigations were performed in 16 subjects. In all individuals CSF and plasma NSE concentration was estimated during the first 24 hours of hospitalization. Mean CSF NSE concentration in patients in very severe clinical state (group I) was 19.8 microg/L compared to 10.46 microg/L in subjects of group II with moderate and mild course of disease. The difference between mean CSF concentrations of this enzyme was statistically significant (p<0.01). The obtained results indicate the usefulness of CSF NSE concentration assessment in estimation of severity of the patient's clinical state. The magnitude of this concentration seems to be also helpful as prognostic marker in purulent, bacterial meningoencephalitis.