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Enhanced Binding and Degradation of the C1q Subcomponent of Complement by Thioglycollate‐Stimulated Guinea Pig Peritoneal Macrophages

Expression of C1q receptors on the plasma membrane of thioglycollate‐stimulated guinea pig peritoneal exudate macrophages increased 1.54 times as compared to unstimulated controls. A Scatchard plot of the binding of 125I‐C1q to the cells revealed that the binding is a result of an increase in the number of receptors and not to an increased affinity of the receptors. Thioglycollate‐.activated macrophages were found to be 1.6 times more active than non‐activated macrophages in the binding of 125 I‐C1q at 4°C. The enhanced binding of 125I‐C1q by activated peritoneal macrophages was reflected in an increase in the amount of 125I‐C1q degraded by these tells as compared to resident peritoneal macrophages. This suggests that stimulation of phagocytic cells leads to an increase in the expression of C1q receptors and to a concomittant increase in the uptake and degradation of C1q.