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[Diagnostic criteria for different clinical variants of diverticular disease].

New diagnostic criteria for different variants of diverticular disease (DD) are considered based on the examination of 110 patients. Patients of group 1 (n = 77) showed no signs of diverticulitis in contrast to group 2 (n = 33). Two control groups comprised 38 patients with chronic hypomotor colitis and 25 practically healthy subjects respectively. Dynamic observations included clinical and endoscopic examination supplemented by morphological and immunohistochemical Studies. It was shown that DD developed in association with undifferentiated dysplasia of connective tissue, increased number of P substance-inducing colonocytes, and lowered density of vasointestinal peptide-reactive cells. Diagnostically significant criteria in patients with diverticulitis were grade II-III intestinal dysbiosis and increased number of mast cells in rectosigmoid nucosa.