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Reply to Hoy and Fitzgerald: Considering homeostatic mechanisms in long-term treatments

We welcome the intent of the letter by Hoy and Fitzgerald (1) in response to our paper (2), linking basic research to clinical findings, but we also recommend caution when doing this. Hoy and Fitzgerald (1) wish to explain the discrepancy they see when using transcranial direct current stimulation (tDCS) in the healthy population versus patients with schizophrenia and, in addition, highlight the perils of using tDCS in healthy individuals. The authors use our study (2) as an example from the basic research literature to help them provide a potential mechanism for their observations.