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Simultaneous quantification of glutamate and glutamine by J‐modulated spectroscopy at 3 Tesla

The echo time (TE) averaged spectrum is the one‐dimensional (1D) cross‐section of the J‐resolved spectrum at J = 0. In multiecho TE‐averaged spectroscopy, glutamate (Glu) is differentiated from glutamine (Gln) at 3 Tesla (T). This method, however, almost entirely suppresses Gln resonance lines around 2.35 ppm, leaving Gln undetermined. This study presents a novel method for quantifying both Glu and Gln using multi‐echo spectral data.