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Effect of plasmapheresis (PP), corticosteroids and cyclophosphamide in essential mixed polyclonal cryoglobulinaemia associated with glomerulonephritis.

In two patients with type III essential cryoglobulinaemia with glomerulonephritis and neurological involvement, the effect of prednisone, plasmapheresis, the combination of both and subsequently the addition of cyclophosphamide was studied. Prednisone alone had no effect, plasmapheresis alone was only temporarily effective in one patient. The combination of prednisone and plasmapheresis was also only temporarily effective. Addition of cyclophosphamide resulted in complete clinical remission in both patients.