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The effects of whole- and partial-body irradiation on circulating anterior pituitary hormones and testosterone and the relationship of these hormones to drug-metabolizing enzymes in the liver.

McTAGGART, J., AND WILLS, E. D., The Effects of Whole- and Partial-Body Irradiation on Circulating Anterior Pituitary Hormones and Testosterone and the Relationship of These Hormones to Drug-Metabolizing Enzymes in the Liver. Radiat. Res. 72, 122-133 (1977). Doses within the range of 850 to 1500 rad given to the whole body, head, or lowertrunk region of male rats cause a marked depression in the rate of oxidative demethylation of drugs in the liver endoplasmic reticulum, 3 to 4 days after the irradiation. The Vmax of the enzyme system is depressed and the Km increased. Irradiation to the whole body, head, or lower trunk also causes a fall in the circulating levels of testosterone and luteinizing hormone (LH) and the concentrations of these hormones are markedly reduced 3 to 4 days after the irradiation. Injections of testosterone or anterior pituitary extract effectively restore the activity of the liver enzyme system after irradiation of the head or lower trunk. It is concluded that whole-body irradiation causes inhibition of drug-metabolizing enzymes in the liver by a complex series of interrelated effects on the