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A comparative study of human and monkey (Macaca irus) fibrinogen degradation products.

Abstract : Immunochemical, physical, and anticoagulant properties of human and monkey (Macaca irus) fibrinogen degradation products (FDPs) were compared by immunoelectrophoresis, Sephadex G-200 gel filtration, and anticoagulant assay. Both species demonstrated a high degree of similarity in the properties and sequence of generation of FDPs derived from in vitro plasmin digestion of highly purified fibrinogen. The results of this study should permit a closer analogy to be drawn between the pathogenic mechanisms of disseminated intravascular coagulation occurring experimentally in monkeys and clinically in humans. (Author)