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Dose Assessment with Different Methods After Exposure To 14C-Labelled Compounds.

An accidental intake of 14C-labelled compound has been followed by long-term monitoring of urine samples. First, the intake and the committed effective dose have been calculated by a generally recommended method and as the value exceeded the investigation level, special dose estimation was performed. Recommendations from ICRP Publications were used for analyses but the measurement data did not fit these models, so the recommended parameter values were deemed incorrect for this compound and this exposure situation. With the measurement data, it was possible to set up a case-specific model based on the actual excretion functions. Afterwards, the committed effective dose was obtained from integrating the total number of decays in the body over 50 y. This case shows that 14C-labelled organic compounds could be very unique when they get incorporated into the body and the absorption and deposition parameters should be used with special care when estimating the dose.