{'fraction_non_alphanumeric': 0.043583535108958835, 'fraction_numerical': 0.010492332526230832, 'mean_word_length': 5.326530612244898, 'pattern_counts': {'":': 0, '<': 2, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Protective role of tetrahydrocurcumin and chlorogenic acid on glycoprotein changes in streptozotocin-nicotinamide-induced diabetic rats

The present study was to evaluate the individual and synergistic effect of two-plant derived phenolic compounds, namely tetrahydrocurcumin (THC) and chlorogenic acid (CGA) on glycoprotein levels in plasma, liver and kidney of normal and streptozotocin (STZ)-nicotinamide (NA)-induced diabetic rats. A single intraperitoneal injection of STZ (45 mg/kg b.w) to rats, lead to a significant (p < 0.05) increase in the levels of fasting plasma glucose and glycoproteins (hexose, hexosamine, fucose and sialic acid), whereas the levels of plasma insulin decreased significantly (p<0.05). THC (80 mg/kg b.w) and CGA (5 mg/kg b.w) as individual and combined dose were administered to diabetic rats for a period of 45 days. The levels of plasma insulin, glucose and glycoproteins were measured. From these observed findings, we suggest that the combined THC/CGA treatment shows more effective than individual treatments in decreasing plasma glucose, glycoproteins and increase insulin levels. This shows significant protection of THC/CGA over glycation of membrane proteins against STZ-NA-induced diabetic rats.