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ANTI-INFLAMMATORY AND ANTIPYRETIC ACTIVITY OF SELECTIVE COX-2 INHIBITOR WITH CONVENTIONAL NSAIDs

Objective: The selective COX-2 inhibitor has high cardiovascular side effects, with low GI side effects, as compare to the conventional NSAID and it is proved that low dose of any drugs is always good for the health due to chances of less adverse effects. So the main objective of this research work is to lower the dose of selective COX -2 inhibitor, combine with a conventional NSAID and find out the pharmacological activity of combination drug, selective cox-2 inhibitor alone and other standard NSAIDs and compare with control. Methods: Carrageenan induced hind paw edema in Rats and Brewer’s yeast induced pyrexia in rat models were used for the evaluation of anti-inflammatory and antipyretic activity. Results: The % age of inhibition of edema at peak hrs i.e. at 3 and 4 hrs were (51.8%) and (49.7%) for standard drug (62.1%) and (59.3%) for test-1 drug (71.4%) and (70.1%). The percentage of reductions in rectal temperature of tests and standard group was shown in Graph-1 b. The present results show that the test-2 possesses a significant antipyretic effect in yeast-provoked elevation of body temperature in rats, and its effect is less than that of paracetamol.