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The effect of 5-bromo-2-thienyl-ethyl ketone thiosemicarbazone on the induced deciduomal response in the rat.

Summary. The effect of 5-bromo-2-thienyl-ethyl ketone thiosemicarbazone (70026) on the deciduomal response was studied to determine the mode of its antifertility activity. The study utilized intact, ovariectomized and hypophysectomized rats that were made pseudopregnant and/or treated with progesterone, corn oil, prolactin and 70026, either alone or in combination. The results indicated that 70026 partially inhibited the deciduomal response by a direct action on the uterus, but also had an additional inhibitory effect by a direct action on the ovary. This latter effect indicated that 70026 inhibited progesterone synthesis and/or secretion from the corpus luteum, or interfered with luteotrophin stimulation of the ovary. Compound 70026 had no significant effect on ovarian weight but it did have a highly significant effect on body weight.