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Glucose tolerance and plasma insulin levels during the last trimester of pregnancy.

Plasma glucose and plasma immunoreactive insulin (IRI) levels were measured during the 75g glucose tolerance test (GTT) in healthy pregnant women, to clarify the changes of glucose metabolism during the last trimester of pregnancy. The glucose tolerance decreased with gestational time. After 33 weeks of gestation, the peak levels of the post-glucose loading occur-red at 60 minutes instead of 30 minutes after glucose ingestion. The parameter that best reflected the decrease in glucose tolerance was the level 60 minutes after glucose ingestion, which at the 33rd gestational week was significantly higher than the level at the 28th gestational week. The IRI reaction accompanying the rise in plasma glucose appeared to increase gradually during gestation, even in the last trimester. The largest increases of plasma IRI levels after glucose loading were seen at or after the 36 th week of gestation.