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Iatrogenic Kaposi’s sarcoma in a myelofibrosis patient treated with ruxolitinib

plexus to the inferior petrous sinuses, which is an important outlet for the infratentorial region. This retrograde pathway could be applied in EMPD, considering that lymphovascular obstructions in pelvic and retroperitoneal lesions are frequently observed. Second, vertebral bone metastases could be predictive factors of CNS metastases, especially leptomeningeal metastases. In breast and lung cancers, leptomeningeal metastases have been already reported as the result of cancer propagation from vertebral or paravertebral metastases. In our cases, all leptomeningeal metastases were detected following vertebral bone metastases. Given that not all cases with vertebral bone metastases in our institute had been investigated for CNS metastases, further investigation will be needed. Our study is limited by the small sample size. Nonetheless, we conclude that the predominant distribution pattern of CNS metastases could be infratentorial and that vertebral bone metastases could be predictive factors of CNS metastases in EMPD. Although it remains unclear whether early detection of brain metastases in EMPD alters survival or quality of life, we should consider investigating the presence of CNS metastases in advanced EMPD, especially with vertebral bone metastases. CONFLICT OF INTEREST: None declared.