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Pre‐ and post‐natal factors influencing allergy

Pre-natal factors There are many maternal-fetal interactions during pregnancy which might influence sensitization of the infant but evidence of scnsitization at birth is rare (Michel et al., 1980; Warner, 1080; Businco et uf., 1983). The mother’s diet might be important, such as the intake of highly-allergenic food during pregnancy. Maternal immunization could, however, specifically suppress IgG antibody response in the offspring by transfer of specific IgG antibodies through the placenta, as has been shown in rats (Jarrett & Hall, 1983; Kleinman, 1983) and suggested in humans (Dannaeus et al., 1978; Casimir et al., 1984). Other possible pre-natal factors which might influence the development of allergic disease in the offspring include: maternal infections and other diseases; smoking (Paganelli et al. , 1979; Rantakallio, 1978; Fogelman, 1980); the use of drugs; and the effects of environmental pollutants, though there is no clear evidence in man.