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Letter by Murakami et al Regarding Article, "Segmental Aortic Stiffness in Children and Young Adults With Connective Tissue Disorders: Relationships With Age, Aortic Size, Rate of Dilation, and Surgical Root Replacement".

We read with great interest the article by Prakash and colleagues,1 which reported that higher aortic stiffness is associated with higher rates of surgical aortic replacement and aortic root dilatation in children and young adults with connective tissue disorders. It is well known that aortic root expansion and stiffening occur together in many clinical settings (so-called aortopathy). What meaning does that have?

Aorta is not only a simple tube but also a functional reservoir. …