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The Importance of Precision Medicine in Type 2 Diabetes Mellitus (T2DM): From Pharmacogenetic and Pharmacoepigenetic Aspects.

BACKGROUND
Type 2 diabetes mellitus (T2DM) is a worldwide disorder as the most important challenges of health-care systems. Controlling the normal glycaemia greatly profit long-term prognosis and gives explanation for early, effective, constant, and safe intervention.


MATERIAL AND METHODS
Finding the main genetic and epigenetic profile of T2DM and the exact molecular targets of T2DM medications can shed a light to its personalized management. The comprehensive information of T2DM was earned through the genome-wide association study (GWAS) studies. In the current review we represent the most important candidate genes of T2DM like CAPN10, TCF7L2, PPAR-γ, IRSs, KCNJ11, WFS1, and HNF homeoboxes. Different genetic variations of candidate gene can predict the efficacy of T2DM personalized strategy medication.


RESULTS
SLCs and AMPK variations are considered for metformin, CYP2C9, KATP channel, CDKAL1, CDKN2A/2B and KCNQ1 for sulphonylureas, OATP1B, and KCNQ1 for repaglinide and the last but not the least ADIPOQ, PPAR-γ, SLC, CYP2C8, and SLCO1B1 for thiazolidinediones response prediction.


CONCLUSION
Taken everything into the consideration, there is an extreme need to determine the genetic status of T2DM patients in some known genetic region before planning the medication strategies.