{'fraction_non_alphanumeric': 0.01940755873340143, 'fraction_numerical': 0.0, 'mean_word_length': 4.975609756097561, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Something Old, Something New and Something Used in Alzheimer's; the Idea of Pore, Ethanol and the Use of Oocytes to Understand the Disease



Alzheimer's disease remains an unsolved public health problem. Recent
studies shifted the focus of the pathogenesis from a neurodegenerative process to a synaptic
failure, including a large group of pathologies called peptide misfolding diseases.


In this line, recent research has proposed new models to study the pathologies such
as frog oocytes, revalidation of a mechanism such as the amyloid pore, and a link of moderate
alcohol consumption with a reduced risk of developing neurodegenerative diseases.


We reviewed the latest publication in this field.


We believe, therefore, that the available data suggest an important role of the
amyloid pore mechanism in the pathogenesis of the Alzheimer's disease, the use of oocytes
for its study, and how a moderate consumption of ethanol could reduce the effects of amyloid
aggregates.