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Mast‐cell—leukocyte cytokine cascades in allergic inflammation

Despite decades of intensive study, the generation of a wide variety of imaginative hypotheses, and the revelation of many interesting and potentially important findings, the role of the mast cell in allergic inflammation is still not fully understood. This statement is especially true in regard to those clinically significant examples of allergic inflammation that occur in man, such as allergic asthma and atopic dermatitis. That the mast cell may have critically important roles in such disorders is. of course, not in question. The issue is not what mast cells mighr do in these responses but what they actually do, how they do it. and, beyond that, the relative importance of the mast cell's role(s) in these reactions compared to those of other cell types that may express functions that are similar to, or overlap, those of the mast cell. The purpose of this brief review is not to consider all of the many potential roles of the mast cell and its diverse mediators in various components of allergic inflammatory responses. Instead, using asthma as the main example, the discussion will focus primarily on the possibility that mast-cell cytokine production represents an important (and therapeutically accessible) link between mast-cell activation and many of the clinically significant features and consequences of allergic inflammation. Inflammation, mast cells, and cytokines in the pathogenesis of allergic asthma