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Inhibitory effects of Leishmanial sphingolipid on Endotoxin induced macrophage activation and sepsis associated inflammatory injury

Sepsis is the reflection of systemic immune response that manifests in the sequential inflammatory process in presence of infection with excessive production of inflammatory mediators and causes severe tissue injuries. Total lipid of attenuated Leishmania donovani establish as a bioactive. Moreover, sphingolipids moderate various cellular processes. So, this finding encourages us to evaluate inflammatory response in system using the microbial sphingolipid.