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Autophagic degradation in human skeletal muscle target fibers

Target fibers are a reliable histological sign of denervating processes in human skeletal muscle biopsies, although their pathogenesis remains obscure. We describe here autophagic multivesicular bodies at the center of target fibers. In addition, mitochondrial swelling and disintegration was observed in the intermediate zone surrounding the target center, which corresponds to the zone of dark staining with oxidative histochemical techniques seen with light microscopy. Honeycomb figures were present at the target center and at the fiber surface. These findings suggest that target fibers are a catabolic or involutional response to muscle denervation.