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Influence of sex Hormones on Calcitonin Gene-Related Peptide in Man: Effects of Sex Difference, Contraceptive Pills and Pregnancy.

Calcitonin gene-related peptide (CGRP) has 37 amino acid residues, and is encoded for by the calcitonin gene. CGRP has been found to be distributed in the central nervous system, in human thyroid and in perivascular nerves. The peptide has been found to possess potent vasodilatory properties in man but it's physiological role is still unclear. However, recent findings show increased plasma levels of CGRP-LI (like immunoreactivity) in the external jugular vein during both common and classical migraine. It is well known that migraine is more common in females than in males and in about two thirds of the migraineous women menses is among the factors conditioning their headache or, in 20% of these the unique trigger.