{'fraction_non_alphanumeric': 0.03651266766020864, 'fraction_numerical': 0.03204172876304024, 'mean_word_length': 5.425837320574162, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
ANTIDEPRESSANT ACTIVITY OF METHANOLIC EXTRACT OF ACORUS CALAMUS LEAVES IN ALBINO MICE

Objective: To evaluate the antidepressant activity of methanolic extract of leaves of Acorus calamus in experimentally induced antidepressant animal models. Methods: Albino mice were divided into 8 groups of 6 mice each. Forced swimming (FST) and Tail suspension tests (TST) were the animal models used to evaluate antidepressant activity. 4 groups were allocated to FST and 4 groups to TST. Control groups were administered normal saline 10ml/kg, standard groupImipramine 15mg/kg, T1 groupAcorus calamus extract(100mg/kg) and T2 groupAC extract(50mg/kg)+ imipramine(7.5mg/kg) orally for a duration of 14 days. Results: Methanolic extract of Acorus calamus leaves produced significant antidepressant effect as shown by reduction in immobility period in both tail suspension test and forced swim test as compared to control. Percent reduction of immobility period during FST by imipramine,T1 and T2 were 49.7%,35.7% and 42.7% respectively and the percent reduction of immobility period during TST by Imipramine,T1 & T2 were 34.3%,22.7% and 28.7% respectively compared to control.Hence T1 and T2 groups showed antidepressant activity comparable to standard. Conclusion: Methanolic extract of Acorus calamus leaves shows considerable antidepressant activity.