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Agmatine‐Morphine Interaction on Nociception in Mice

Abstract: The aim of this study was to investigate the possible participation of nitric oxide in the agmatine‐mediated potentiation of morphine‐induced analgesia in mice. Agmatine and L‐NAME (a nitric oxide synthesis inhibitor) enhanced morphine‐induced analgesia in the tail flick test, but not in the hot plate test. L‐NAME did not block the agmatine‐induced potentiation of morphine effect. Our results indicate that agmatine potentiates morphine‐induced spinal but not supraspinal analgesia, and that this effect is not mediated by a nitric oxide‐dependent mechanism.