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Isocitric and citric acid in human prostatic and seminal fluid: Implications for prostatic metabolism and secretion

Human prostatic secretion is remarkably rich in citric acid but the mechanisms to account for this accumulation are not well understood. One factor may be the extent of citrate oxidation to isocitrate, catalyzed by aconitase. The citrate‐to‐isocitrate ratio will help characterize the relative significance of this reaction in prostatic production and secretion of citrate.