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Rhythm of digestion: keeping time in the gastrointestinal tract

1. The best characterized mammalian circadian rhythms follow a light‐entrained central master pacemaker in the suprachiasmatic nucleus and are associated with fluctuations in the activities of clock genes, including Clock, Bmal1, Per and Cry, the products of which bind to sequences in the promoters of effector genes. This is the central clock.