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CHANGES OF THE THYROID HORMONES CONCENTRATION AND THE BIOCHEMICAL PARAMETERSFEAUTURES OF LYMPH AND BLOOD OF RAT WITH HYPOTHYROIDISM

The article considers the influence of the mercazolilum management on the hormonal state in the lymph and blood of rates. The study shows that after mercazolilum management and the hypothyroidism signs appearance in rats, there was a decrement of lymph flow from the thoracic lymphatic duct. Changes in the hormonal and biochemical composition of the lymph were observed. There were disturbances not only of the metabolism in the lymph, but also of the functional state of the body. There were disturbances of rheologic and physicochemical parameters of lymph and blood at the experimentative hypothyroidism of rats: viscosity has been increased, coagulability and number of erythrocytes have been decreased, thrombocytes and leucocytes in blood have been increased. It has been led to a decrease of rats of the 2nd experienced group in T3, T4 content and increase of thyrotropic hormone in lymph and blood which reflected the occurrence of their hypothyroidism. Experiments showed that Т3 content in rats with hypothyroidism has decreased by 45.7% and Т4 by 35.6% in lymph, and in blood Т3 by 43,5% and Т4 by 41,6% have decreased compared with the control group of animals.