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Radioelectroencephalographic characterization of tenilsetam (CAS 997), a putative nootropic compound, in the freely behaving rat

Recording, telemetric trandmission, and spectral analysis of field potentials from frontal cortex, hippocampus, striatum, and reticular formation of the rat brain were used to monitor the effect of tenilsetam (CAS 997) and piracetam on the central nervous in delta and alpha2 power in all brai areas. Dose‐dependent decreases in alpha1 power were seen in the frontal cortex, striatum, and reticular formation, whereas the hippocampal alpha1 activity increased (100 mg/kg) or remained unaffected. These effects were dose‐dependent and lasted for at least 90 min. In the presence of piracetam, changes in brain electrical activity were dominated by an overall decrease in alpha1 activity and by less pronounced effects on beta1 activity. The spectral pattern profile induced by tenilsetam was compared to the “fingerprints” of a great number of different drugs from our data base. Some similarities to the action of fluvoxamine and SK&F 38393 point to changes in serotonergic and dopaminergic transmission. The present data show the functional outcome of interactions with different aspects of neurotranmission and suggest that the “nootropic” drug tenilsetam enhances vigilance by shifting the balance of neurotransmission to a status resembling low serotonergic and, at the same time, high dopaminergic activity. These drugs obviously not only improve brain function under pathological conditions but can also affects electrical activity of the intact brain.