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[Relationship between the expression of E-cadherin and MVD and its significance in lung cancer].

BACKGROUND
To study the relationship between the expression of E-cadherin and MVD in lung cancer and its significance.


METHODS
The expressions of E-cadherin and factor VIII were detected in 104 lung cancer tissues by immunohistochemical method, and MVD was calculated by image analysis system.


RESULTS
The expression of E-cadherin was significantly related to the differentiation of lung cancer (P < 0.05). A negative correlation was observed between E-cadherin expression and MVD in lung cancer tissues (P= 0.047).


CONCLUSIONS
Downexpression of E-cadherin and increase of MVD may play an important role in the invasion and metastasis of lung cancer, and may also be used as a useful marker for tumor prognosis.