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Characterization of Glycine Rich Proteins in Amblyomma americanum

The feeding habits of ticks require extended attachment of the tick on the host. This extended interaction with the host's immune system requires the tick to shield itself by modulating the host immune response with the use of multiple families of pharmacologically active compounds. Glycine‐rich proteins are secreted from the salivary glands into the host where they may have multiple functions including: attachment (proteinaceous cement matrix surrounding the mouthparts), anti‐hemostasis (block blood clotting factors), anti‐inflammatory (prevent pro‐inflammatory signals or induce anti‐inflammatory signals), or anti‐microbial (prevent the growth or establishment of microbial organisms).