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Chronic Rhinosinusitis With Nasal Polyps is Associated With Decreased Expression of Mucosal Interleukin 22 Receptor

Introduction: Chronic rhinosinusitis with nasal polyps (CRSwNP) is an inflammatory disorder of the sinonasal mucosa that is frequently associated with microbial colonization. Innate defense mechanisms at the mucosal surface are critical in protecting the host from airborne environmental pathogens. Recent studies of skin and gastrointestinal tract inflammatory diseases have shown that stimulation of the interleukin‐22 receptor (IL‐22R1) nonspecifically increases innate immune responses. The potential role of IL‐22R1 in the pathogenesis of CRSwNP has never been explored.