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The well-studied glucocorticoid receptor (GR) regulates diverse cellular functions, including energy metabolism, immunity, and cell fate. Laura Matthews et al. (pp. 5479–5484) report that the GR may also help to coordinate cell division. The authors found that a modified version of the GR accumulates at spindle centrosomes during mitosis, and that the distribution of the GR overlaps with that of an enzyme called Aurora kinase. The authors also found that loss of GR interferes with mitosis and triggers apoptosis in cultured human and mouse cells. Older mice engineered to express low levels of GR exhibited high rates of tumor formation, compared with GR-expressing controls, and the authors observed low levels of GR expression within those tumors. An analysis of common human cancers, including liver, lung, prostate, colon, and breast cancers, revealed that GR expression is reduced, suggesting a relationship between GR and malignant progression. According to the authors, the findings suggest that GR plays an unexpected role in promoting accurate chromosome segregation during mitosis, and may therefore function as a tumor suppressor. — A.G. Comparing high-throughput sequencing methods