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Saccharin and cancer.

Does saccharin cause cancer? The short answer is "yes, if you are a male rat and saccharin has made up more than 1% of your diet since your were born." But that's not a very satisfying answer for you or me. In 1970 there were reports that saccharin and saccharine + cyclamate combinations caused bladder tumors in rats [1,2]. Since then, there have been many additional studies, investigating such variables as species (the effect is seen only in rats, not in mice, hamsters, guinea pigs, or monkeys), gender (the effect is observed primarily in male rats), and dosage (tumor incidence increases as the dosage of saccharin goes from 1% to 7% of the total diet (for comparison, saccharin would make up no more than 0.01% of a sweetened soft drink). In the USA, the FDA was prepared to ban the use of saccharin in 1977, but Congress intervened, passing legislation that, instead, required saccharincontaining foods to carry the following warning label: