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Insulinoma‐associated protein 1 expression in primary and metastatic neuroendocrine neoplasms of the gastrointestinal and pancreaticobiliary tracts

Insulinoma‐associated protein 1 (INSM1) is a transcription factor that is expressed in developing and mature neuroendocrine tissue. Recent studies have shown that INSM1 is a sensitive marker for neuroendocrine tumours. The aims of this study were to evaluate INSM1 expression in primary gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) and in their known metastases, in order to assess its sensitivity as compared with chromogranin‐A (CgA) and synaptophysin (SYN), and to evaluate any change in expression between primary and metastatic disease.