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The human RBM10 gene dually encodes a repressor of ribosome biogenesis that downregulates cell proliferation

Ribosome biogenesis in eukaryotes is a highly regulated, essential cellular process. However, few repressors of ribosome biogenesis have been identified. Here, we identify and define the function of MINAS-60 (MIcroprotein that Negatively regulates ASsembly of the pre-60S ribosomal subunit), a 130-amino acid protein co-encoded with the human pre-mRNA splicing regulator and tumor suppressor protein RBM10. MINAS-60 localizes to the nucleolus, where it associates with multiple pre-60S assembly factors. Depletion of MINAS-60 increases the amount of mature 60S ribosomal subunit in the cytoplasm and, consequently, upregulates global protein synthesis and cell proliferation.