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METABOLIC INFLUENCES IN EXPERIMENTAL THROMBOSIS *

Studies presented in this report demonstrate that intravascular coagulation and thrombosis in the whole animal can be greatly influenced by noncoagulation factors, such as metabolic, endocrinologic, and nutritional states. Injection of a partially purified human serum procoagulant fraction produced no significant clotting abnormalities in normal fed rats; however, injection of an identical preparation in fasted, diabetic, and obese rats produced hypercoagulability of blood, thrombosis, and hemorrhage. Glucose injection in fasted rats and insulin injection in diabetic rats reversed their susceptibility to thrombosis. The concentrations of serum free fatty acids were shown to be elevated in the susceptible animals; however, they returned to normal in fasted and diabetic rats after injections of glucose and insulin, respectively. Infusion of free fatty acid-albumin preparations in normal fed rats rendered the animals susceptible to thrombosis when challenged with the serum procoagulant fraction.