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Relationship between concentration of IL-7 and cellular immunity in peripheral blood of the patients with chronic hepatitis B

Objective To study the relationship of the concentration of IL- 7 with the percentage of T lymphocyte subsets and regulatory T cells in peripheral blood of the patients with chronic hepatitis B and explore the effects of IL- 7 on cellular immune function. Methods The 48 patients were divided into CHB group(30 cases) and HBV carrier group(18cases). In addition, there was a health control group(14 cases).The concentration of IL-7 in the peripheral blood in the chronic hepatitis B group, the chronic hepatitis B virus(HBV) carrier group, and the healthy control group were measured by ELISA and the percentage of T lymphocyte subsets and CD4+CD25+regulatory T cells were detected by the flow cytometry. Results The concentration of IL-7 was(1.68 ± 0.58) ng/ml in the CHB group,(3.83 ± 0.62) ng/ml in HBV carriers group and(6.25 ±0.32) ng/m L in the healthy control group, there were significant differences among the 3 groups(P0.05). The percentage of CD4+T cells in the CHB group, the HBV carriers group, and the healthy control group were(31.3 ± 3.3) %,(38.1 ± 6.8)% and(43.2 ± 9.4)%, respectively; CD8+T cells were(24.8 ± 5.2)%,(28.1 ± 3.4)% and(30.5 ± 8.6)%,respectively; CD4+CD25+regulatory T cells were(10.9 ± 1.3)%,(7.4 ± 1.0)% and(4.2 ± 1.1)%,respectively. The concentration of IL-7 of the CHB group was significantly lower than that of HBV carrier group or healthy control group, it was negatively correlated with the percentage of CD4+T cells(r1=-0.58, P0.05) and CD4+CD25+regulate T cells(r3=- 0.43, P0.05). However, it is positively correlated with the percentage of CD8+T cells(r2=0.63, P0.05). Conclusion IL-7 regulates negatively of regulatory T cells, and promotes the CD8+T cellular immunity of the patients with chronic hepatitis B.