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No impact of ghrelin on adaptive hyperphagia in short bowel syndrome

Adaptive hyperphagia (AH) is associated with reduced dependence on parenteral nutrition (PN) in patients with short bowel syndrome (SBS), but mechanisms have not been described. Ghrelin (GHR) has orexigenic effects, while peptide YY (PYY) reduces intake. We evaluated whether GHR or PYY were related to caloric intake or absorption in patients with SBS.