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The Minimal Size of Liposome‐Based Model Cells Brings about a Remarkably Enhanced Entrapment and Protein Synthesis

Captured life: The complex transcription–translation machinery can successfully synthesize enhanced green fluorescent protein inside 100 nm (radius) lipid vesicles. Being the smallest synthetic bioreactor, such a model suggests that very small compartments can sustain (minimal) cellular life. Since classical Poisson statistics fails to predict the spontaneous formation of EGFP‐expressing liposomes, we propose a possible super‐concentration effect.