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Vibration‐induced changes in oxidative stress and expression of inflammatory factors are frequency dependent

Repetitive exposure to vibration through the use of powered hand tools is associated with the development of vibration white finger (VWF), a disorder that is characterized by cold‐induced vasospasms that result in blanching of the skin. The risk of developing VWF appears to be dependent upon the frequency of the exposure. The goal of this study was to assess frequency dependent changes in gene expression and oxidative stress in a rat‐tail model of VWF. Rats (n = 5/group) were exposed to vibration (63, 125, or 250 Hz) or control conditions for 4 h/day for 10 days. After the last exposure, gene expression and oxidative stress were assessed in ventral tail arteries. Transcript levels of pro‐inflammatory factors were increased in arteries of rats exposed to 63 Hz vibration compared to controls. In contrast, oxidative stress (e.g., peroxynitrite) was higher in rats exposed to 125 and 250 Hz vibration. These results demonstrate that the biological responses of peripheral arteries to vibration are frequency dependent. The frequency dependent differences in these responses may affect the risk of developing vibration‐induced vascular dysfunction.