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New regenerative approach to atrophic rhinitis using autologous lipoaspirate transfer and platelet‐rich plasma in five patients: Our Experience

Dear Editor, Atrophic rhinitis (AR) is a debilitating chronic nasalmucosal disease of unknown aetiology. The condition is characterised by progressive nasal mucosal atrophy, atrophy of the underlying bone of the turbinate, abnormal widening of the nasal cavities with paradoxical nasal obstruction and formation of viscid secretions and dried crusts leading to a characteristic fetor (ozaena). Atrophic Rhinitis was first described by Fraenkel in 1876, but the aetiology of the disease is still a matter of dispute. Various methods of treatment, both medical and surgical, have been tried without much success. However, clinical features of the disease can be attributed to the destruction of the normal respiratory epithelium and metaplasia to a nonciliated squamous epithelium and loss of mucociliary clearance. Thus the curative treatment of AR should address the reversal of this basic pathologic alteration in its microanatomy. Promotion of regeneration of normal nasal mucosa must be the aim of any treatment for long-lasting success. The aim of this article is to present a new regenerative approach to reverse atrophy of nasal mucosa by grafting autologous of lipoaspirate.