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Effect of orally administered polysaccharide from kefir grain on delayed-type hypersensitivity and tumor growth in mice.

The effect of oral administration of a polysaccharide (KGF-C), isolated from the kefir grain, on delayed-type hypersensitivity (DTH) induced by picryl chloride and on the growth of solid tumor was examined in mice. KGF-C caused an increase in DTH response in intact mice and also tumor-bearing mice. The growth of tumor inoculated after the DTH test was markedly inhibited in the groups with high DTH response. A significant correlation between the DTH response and the antitumor activity was observed in intact mice.