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Preparation of Nanoscale Graphene Oxide and Its Application on β-Catenin Expression in Pediatric Osteosarcoma Cells Combine with Probiotics

This work aimed to study the effect of nanoscale graphene oxide (NGO) and probiotics on the expression of β-catenin (chain protein) in pediatric osteosarcoma (OSA) cells. Ninety pediatric patients with OSA were taken as the research object, who were classified into control
 group, GO (NGO) group, and probiotics group. Their tumor tissues were collected and cultured. NGO materials were prepared by adding N, N-dimethylformamide solvent into graphite powder. The control group was interfered with normal saline, the GO group was treated with NGO, and the probiotics
 group was interfered with mixed bacterial solution. The results showed that the expression of β-catenin mRNA in GO group and probiotics group was considerably inferior to control group (P < 0.05). Expression of β-catenin protein in control group increased,
 while that in GO group and probiotics group decreased. The OSA cell counts of GO group and probiotics group were evidently lower relative to control group (P < 0.05). In short, NGO and probiotics can reduce the expression of β-catenin protein in pediatric OSA cells, and
 inhibition of signaling pathway that involved β-catenin can suppress the proliferation of OSA cells.