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Adenosine attenuates the lipopolysaccharide (LPS) induced endothelial barrier dysfunction in murine model of acute lung injury

Acute lung injury (ALI) affects approximately 200,000 people in the United States every year. A basic cause is pulmonary endothelial cell (EC) barrier disruption and the ensuing inflammation and increased permeability of the EC. Our previous studies on the human pulmonary arterial endothelial cells have shown that adenosine (AD), an endogenous purine nucleoside, attenuates the EC barrier. The goal of our experiments was to evaluate AD attenuation on the EC barrier in LPS treated mice.