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Cytotoxic properties of Acorus calamus in MCF -7 breast cancer cells

In this study cytotoxic effect of Acorus calamus extract was evaluated on breast carcinoma (MCF-7) cell lines. MCF-7 cells were cultured in DMEM medium and incubated with different concentrations (18.75, 37.5, 75, 150 and 300 g/ml) of Acorus calamus methanol extract. Cell viability was assessed by MTT assay. Acorus calamus decreased cell viability in malignant cells in a concentration dependent manner. The IC50 values in MCF-7 cells were determined as 52.07 g/ml. It may be concluded that Acorus calamus can cause cell death in MCF-7 cancer cells which can be considered as a promising chemotherapeutic agent in breast cancer treatment.