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Hemodynamic Changes during Acute Salicylate intoxication in Conscious Dogs

Summary The hemodynamic changes following intravenous infusions of sodium salicylate were measured in conscious dogs. The sodium salicylate produced dose-dependent increases in heart rate, cardiac output, and pulmonary arterial pressure, and a dose-dependent decrease in total peripheral resistance with maximum responses being obtained at the dose of 200 mg/kg. Sodium salicylate also produced decreases in left atrial pressure and central venous pressure and a biphasic response in aortic pressure. Pretreatment with propranolol significantly attenuated the increases in heart rate and cardiac output, as well as the decrease in total peripheral resistance elicited by salicylate, thus implying that the salicylate-induced cardiovascular responses are mediated partly through the activation of beta adrenergic receptors.