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Variation in lymphocyte reactivity to histoplasmin during the course of chronic pulmonary histoplasmosis.

Lymphocyte transformation in response to histoplasmin was determined in vitro serially in 3 representative patients with active, chronic, pulmonary histoplasmosis, one with early, one with fairly stable, long-standing, and one with eventually terminal, long-standing disease. Periods of exacerbation were associated with diminished lymphocyte reactivity to histoplasmin in 2 of the 3 patients. The other patient exhibited very high order histoplasmin-induced transformation at the time of active disease. Temporary low-order lymphocyte reactivity was specific for histoplasmin-induced transformation in one of the 2 patients with decreased histoplasmin-induced transformation but reflected a broader defect in lymphocyte function as determined in the terminally ill patient by impaired transformation induced by Candida albicans extract and phytohemagglutinin. Histoplasmin-induced lymphocyte transformation in vitro provides one parameter of cellular immunity that appears to provide pertinent ancillary data aiding in ...