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[Progress in research on the functions of calcium and chloride channels in vascular endothelial cells].

Endothelial cells (EC) lining the inner lumen of the blood vessels are rich in ion channels that constitute the basis of a unique signal transduction function of the cells. The abundance of calcium and chloride channels in the plasma membrane of these nonexcitable cells has raised questions in regard to their functional roles. This review presents evidence for the involvement of these channels in the endothelial cell functions, in an attempt to further explore the relationship between cardiovascular diseases and functional abnormalities of the ion channels.