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[Analysis of the damaging action of different doses of nicotine on the female germ cells of rat fetuses].

The conducted studies have shown the gametotropic dose-dependent nicotine effect revealed both at the light-optic and ultrastructural levels. The revealed disturbances in oocytes may be regarded as a nonspecific response of the sex cells which is observed mainly in damage of the membrane oocyte components and specific (for sex cells) structure, a synaptonemal complex. Disturbances in the somatic ovary cells manifest only with a high nicotine dose.