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Wnt antagonist gene polymorphisms and renal cancer

Epigenetic silencing of several wingless‐type mouse mammary tumor virus integration site (Wnt) pathway‐related genes has been reported in renal cancer. Except for the T‐cell factor 4 gene TCF4, there are no reports regarding Wnt pathway gene polymorphisms in renal cancer. Therefore, the authors of this report hypothesized that the polymorphisms in Wnt signaling genes may be risk factors for renal cancer.