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A9353 Assessing hip index as a marker for insulin resistance in the general Chinese population without diabete

Objectives: A new anthropometric measurement (Hip Index, HI) was developed, and it demonstrated a U-shaped relationship to mortality in the general American population. The aims of our study were to examine the discriminatory power of HI for insulin resistance in the general Chinese population without diabetes. Methods: In 2007, a cross-sectional study was conducted among 711 individuals in an urban community located in Chengdu, China. Finally, 570 individuals without diabetes were available for analysis (male: 56.1%, mean age: 62.3 ± 6.5 years). Insulin resistance was assessed by homeostasis model assessment. Areas under the receiver operating characteristic (ROC) curves were determined to identify variables/models that could discriminate insulin resistance. Results: HI was not associated with insulin resistance even after adjustment for BMI, WC and a body shape index (ABSI), and the area under the ROC curve was 0.464 (95%CI: 0.402 – 0.526), which had no discriminatory power for insulin resistance. However, the traditional risk markers, such as BMI, WC, ABSI and fasting plasma glucose (FPG) had better discriminatory power for insulin resistance. The areas under the ROC curves for BMI, ABSI, WC and FPG were 0.753 (95%CI: 0.706 – 0.801), 0.618 (95%CI: 0.561 – 0.675), 0.749 (95%CI: 0.700 – 0.797), and 0.752 (95%CI: 0.705 – 0.799), respectively. Furthermore, combination with HI, BMI and other known risk factors could not improve the discriminatory power for insulin resistance. Conclusion: HI was not an independent risk factor for insulin resistance and had no power to discriminate insulin resistance in the general Chinese population without diabetes.