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Transactivation of epidermal growth factor receptor after heparin‐binding epidermal growth factor‐like growth factor shedding in the migration of prostate cancer cells promoted by bombesin

A pathway consisting of bombesin, G‐protein coupling receptors (GPCRs), metalloproteases, pro‐heparin‐binding epidermal growth factor (proHB‐EGF), and epidermal growth factor receptor (EGFR) has been reported in prostate cancer cells. The occurrence of HB‐EGF shedding from proHB‐EGF in this pathway, however, has not been proven directly. In addition, it is still unclear how much this pathway contributes to the migration of prostate cancer cells. In this study, we tried to directly elucidate HB‐EGF shedding in this pathway and to determine its contribution to the migration of prostate cancer cells.