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The Effects of Eight Weeks Moderate- and High-Intensity Circuit Resistance Training on the Levels of Serum Amyloid A and Insulin Resistance in Sedentary Men

Introduction: Obesity-related inflammation has an important role in increasing the risk of various pathological conditions, including insulin resistance. In this study, the effects of 8 weeks of moderate and high-intensity circuit resistance training on the levels of serum amyloid A (SAA) and insulin resistance were investigated in sedentary men.Methods: In this study, 36 sedentary men (average BMI: 30.64 ± 3.14 kg/m2, age of 20 to 35 years old) were randomly assigned to the control (C), moderate-intensity circuit resistance training (MRT), and high-intensity circuit resistance training (HRT) groups. The training protocol was performed during eight weeks (three sessions per week). Blood samples were collected before and after eight weeks of training, and serum levels of SAA, insulin, and glucose were measured. The data were analyzed by SPSS-24 software using the analysis of covariance (ANCOVA) test with the Bonferroni post hoc test.Results: The present study’s findings indicated that SAA levels and insulin resistance significantly reduced in the HRT and MRT groups compared to the control group (P < 0.001). However, our results showed that the changes observed in SAA and insulin resistance were not significantly different between the HRT and MRT groups (P > 0.05).Conclusion: It seems that HRT has no extra effects on inflammation and insulin resistance compared to MRT; however, changes in the levels of other inflammatory mediators should be determined.