{'fraction_non_alphanumeric': 0.0403971344490354, 'fraction_numerical': 0.024612823637822894, 'mean_word_length': 5.5566166439290585, 'pattern_counts': {'":': 0, '<': 2, '<?xml version=': 0, '>': 1, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 1, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Prevalence of Common Gynecological Conditions in the Middle East: Systematic Review and Meta-Analysis

Introduction: High prevalence of gynecological conditions in women of Middle Eastern origin is reported, likely due to regional risk factors and mediators. The objective of this systematic review and meta-analysis is to investigate the prevalence of polycystic ovary syndrome (PCOS), endometriosis, uterine fibroids, and adenomyosis in women of Middle Eastern origin. Methods: MEDLINE, EMBASE, PsycINFO, Global Health, and Google Scholar databases were searched from database inception until 14 February 2021 to identify relevant studies. Peer-reviewed research articles that reported the prevalence of PCOS, endometriosis, uterine fibroids, and adenomyosis in the Middle Eastern population were written in English or Arabic. The primary outcome was the estimated pooled prevalence of PCOS, endometriosis, uterine fibroids, and adenomyosis in the Middle Eastern populations. The secondary outcome was to assess the evidence in the data for the presence of heterogeneity, by conducting subtype-pooled analysis of prevalence estimates of the conditions. Total weighted prevalence was calculated via Freeman–Tukey arcsine transformation and heterogeneity through the I2 statistic. Quality control was performed using GRADE criteria. Results: A total of 47 studies, 26 on PCOS, 12 on endometriosis, eight on uterine fibroids, and seven on adenomyosis, were included. The pooled prevalence of PCOS diagnosed according to the NIH criteria was 8.9% (95% CI: 6.5–11.7; prevalence range: 4.0–27.6%), with a higher prevalence from the Gulf Arab states (18.8%, 95% CI: 9.5–30.3; range: 12.1–27.6%). According to the Rotterdam criteria, the pooled prevalence of PCOS was 11.9% (95% CI: 7.1–17.7; range: 3.4–19.9%) with studies limited to the Persian and Levant regions. Endometriosis was diagnosed in 12.9% (95% CI: 4.2–25.4; range: 4.2–21.0%) of women undergoing laparoscopy, for any indication. Uterine fibroid and adenomyosis prevalence of women was 30.6% (95% CI: 24.9–36.7; range: 18.5–42.6%) and 30.8% (95% CI: 27.1–34.6, range: 25.6–37.7%), respectively. Heterogeneity was present between studies due to statistical and methodological inconsistencies between studies, and quality of evidence was low due to sample size and unrepresentative participant selection. Conclusion: This is the first review that has reported the prevalence of gynecological diseases in the Middle Eastern population, suggesting that gynecological morbidity is a public health concern. Due to the health disparities in women, further research is required to understand the relative roles of environmental and genetic factors in the region to serve as a benchmark for evaluation and comparative purposes with other populations.


INTRODUCTION
Polycystic ovary syndrome (PCOS), endometriosis, uterine fibroids, and adenomyosis are common benign gynecological conditions that affect women of reproductive age. They are often associated with dysfunctional uterine bleeding, pelvic pain, subfertility, psychological morbidity, and comorbid diseases (1)(2)(3)(4). Genetic and environmental factors contribute to the risk of gynecological conditions, but none are currently specific enough to be clinically relevant. In addition, little is known regarding the reasons for the heterogeneity in symptomatology and contributing factors attributable to gynecological conditions in different populations of women, especially women of Middle Eastern origin. Table 1 summarizes the clinical epidemiology of PCOS, uterine fibroids, endometriosis, and adenomyosis, based on global statistics of mainly European ancestry populations.
The Middle East represents 6.8% of the world's population (23 countries), yet it contributes <1% toward scientific research (28)(29)(30)(31). Cross-population comparisons and regional differences, influenced by geographic, cultural, socioeconomic, genetic, and environmental factors, may alter health outcome measures associated with prevalence, symptomatology, diagnosis, and management of gynecological phenotypes. A high prevalence of gynecological conditions has been suggested in women of Middle Eastern origin, possibly due to consanguinity, obesity rates, environmental toxins from war exposure, and lack of awareness of reproductive health among adolescence (32)(33)(34)(35)(36)(37).
The Middle East is a transcontinental region that consists of the Gulf Cooperative Council (GCC) Region (Bahrain, Kuwait, Oman, Qatar, Saudi Arabia, United Arab Emirates, Yemen), the Levant region (Cyprus, Iraq, Israel, Jordan, Lebanon, Palestine, Syria, Turkey), the North African region (Algeria, Egypt, Libya, Morocco, Somalia, Sudan, Tunisia), and the Persian region (Iran). The Middle Eastern populations have different degrees of genetic admixture, and higher prevalence of globally rare genetic variations with a highly conserved gene pool, due to consanguineous marriages and intercontinental migration (38)(39)(40)(41). Consanguineous marriages account for 20-50% of marriages in the Arab ancestry Middle Eastern populations, resulting in higher frequency of recessive Mendelian diseases, large prevalence of deleterious genetic missense variants, and community-specific founder mutations (33,42,43). Nevertheless, the Middle East has a very diverse ancestral background, due to intercontinental migration between Africa, Asia, and Europe. Nine Middle Eastern countries have ranked highest in the global obesity statistics, with 70-75% of their populations being obese or overweight, with a 2-fold risk among women vs. men (36,(44)(45)(46)(47)(48). Physical inactivity and obesity rates in the region have been associated with gynecological diseases and menstrual disorders (49,50). Additionally, exposure to war and environmental toxins may alter circulating hormone levels and the immune system of women (51).
This systematic review critically assesses the available evidence and quality of epidemiological studies that focus on the prevalence of common benign gynecological diseases in Middle Eastern populations, to inform public health policy and encourage studies into risk factors and prevention. The primary aim was to conduct a systematic review and meta-analysis of the prevalence of polycystic ovary syndrome, endometriosis, uterine fibroids, and adenomyosis in women of Middle Eastern origin. The secondary aim was to assess the evidence in the data for the presence of heterogeneity by conducting subtype-pooled analysis of prevalence estimates of the conditions.

Search Strategy
This systematic review was reported in accordance with PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines (52,53) and registered for inclusion in PROSPERO: CRD42019119804. The electronic bibliographic databases, MEDLINE, EMBASE, PsycINFO, and GLOBAL HEALTH (through the OVID platform), and Google Scholar database, were searched from database inception until 14 February 2021. Search terms included a combination of free-text or controlled vocabulary terms (MeSH and EMTREE) for gynecological conditions including "Polycystic Ovary Syndrome, " "Endometriosis, " "Uterine Fibroids, " and "Adenomyosis." We combined these with terms related to "Epidemiology" and "Prevalence" -related terms and terms for the "Middle East" -related countries. No other limits were applied to the search to obtain a comprehensive literature including the maximum possible number of studies. Details of the full search strategy used for the MEDLINE database are provided in Supplementary Text 1.

Eligibility Criteria and Selection of Studies
Peer-reviewed research articles that reported the prevalence of PCOS, endometriosis, uterine fibroids, and adenomyosis in women of Middle Eastern origin were included, in English and Arabic languages. The primary aim was to estimate the pooled prevalence estimate of PCOS, endometriosis, uterine fibroids, and adenomyosis in the Middle East, based on the following diagnostic criteria: NIH (54) and Rotterdam criteria (55) for PCOS; laparoscopic diagnosis for endometriosis; ultrasound sonography, MRI, and/or hysterectomy for adenomyosis; and ultrasound sonography, MRI, and/or hysterectomy for uterine fibroids. The secondary aim was to assess the evidence in the prevalence data for the presence of heterogeneity, in association to the following characteristics: ascertainment criteria (hospital-based/population-based), diagnostic criteria, age group of participants (adolescent/adult), country of origin (GCC region/Levant region/North Africa region/Persian region), type of study design (cross-sectional/cohort study), and availability of health insurance coverage.
The study outcomes to assess the pooled prevalence of PCOS were population-based study with the NIH criteria; populationbased study with the Rotterdam criteria; hospital-based study with the Rotterdam criteria for any gynecological indication; and hospital-based study with the Rotterdam criteria for infertility investigation. For the pooled prevalence of endometriosis, distinction was made between population-based studies with a laparoscopic confirmation; hospital-based studies with a laparoscopic confirmation for any gynecological indication; and hospital-based studies with a laparoscopic confirmation for infertility investigation. The pooled prevalence of uterine fibroids and adenomyosis was divided into hospital-based studies with a hysterectomy or imaging diagnosis for any gynecological indication and hospital-based studies with a hysterectomy or imaging diagnosis for abnormal uterine bleeding investigation.
To reduce the risk of selection bias, methodological bias, and heterogeneity, studies were included in the meta-analysis when (i) the sample size involved >100 participants; (ii) diagnostic criteria were described; and (iii) prevalence estimates were reported. Reviews, editorials, and organizational guidelines were excluded to avoid bias toward more frequently cited publications. Case reports/series were excluded given that they use no control group to compare outcomes and have little statistical validity.
Conference abstracts were excluded as there was no access to the full report and the studies were not peer-reviewed. To avoid overrepresentation of cases, when several studies on the same series of participants were published, only the report with the largest sample size was included in the meta-analysis.

Data Extraction
Retrieved articles were uploaded to EndNote and duplicates deleted. One reviewer (M.M.) reviewed the full library for relevance. A second reviewer (N.R.) reviewed the retrieved articles; inter-reviewer concordance was checked, and the third reviewer (K.Z.) adjudicated discordant results. A second round of review was conducted, and full texts were assessed for inclusion. Data was extracted into a standard form including study design, participant characteristics, ascertainment method, nationality, diagnostic criteria, confounding factors, prevalence estimates, and outcome measures. Missing data were collected where possible by emailing the corresponding author, or through statistical calculations reported in the Cochrane handbook for systematic reviews (56). All procedures conformed to the guidelines for systematic review and meta-analysis of observational studies in epidemiology: the Meta-analysis Of Observational Studies in Epidemiology Checklist (57).

Assessment of Risk of Bias
The quality control, assurance, and bias of the studies were assessed by two independent reviewers (M.M. and N.R.) using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) criteria (58,59). The quality of evidence was monitored for each study based on risk of bias, imprecision, inconsistency, indirectness, and publication bias and scored on four levels of evidence: very low, low, moderate, and high. The studies and outcomes were rated down for clinical heterogeneity, methodological heterogeneity, unrepresentative control groups, insufficient diagnostic criteria for case definition, lack of adjustment to confounding variables, unclear selection criteria, sample size, confidence interval around effect estimate, and selection bias.

Data Synthesis
Statistical analyses were conducted using the metaprop function in R (R package: meta, Schwarzer 2008, Version 2.7.1). Meta-analysis was used to synthesize the pooling proportion estimates of the gynecological condition. The Freeman-Tukey double arcsine transformation was applied for normalizing and variance stabilizing of the proportion sampling distribution. This transformation also provided confidence limits of proportions between zero and one. Heterogeneity among studies was assessed via I 2 statistic. I 2 of 50% or above was designated significant heterogeneity and 30-49% moderate heterogeneity (60). The random-effect model of DerSimonian and Laird was used to estimate the pooled prevalence and its 95% CI, and I 2 heterogeneity was calculated for sensitivity analysis. Significant heterogeneity was explored by performing post-hoc subgroup meta-analyses to allow reliable conclusions to be drawn from analyses that involved subgroups. Forest plots demonstrate the pooled prevalence estimates of the meta-analysis results. P < 0.05 was used as the threshold for statistical significance.

Study Selection and Characteristics
The search strategy across all databases retrieved 9,307 studies, 6,754 studies after duplicates were removed ( Figure 1); 6,269 failed to meet the inclusion criteria based on abstract review. Following a full-text review of 485 studies, 438 were excluded because they did not meet the inclusion criteria. Of the 47 articles, 26 covered prevalence of PCOS, 12 endometriosis, 8 uterine fibroids, and 7 adenomyosis. There were 25 retrospective studies using electronic medical records and 22 cross-sectional studies; 29 were hospital-based and 18 population-based. There were 14 studies published from the GCC region, 14 studies from the Persian region, 14 studies from the Levant region, and 5 studies from the North African region. Detailed characteristics of the studies included are given in Table 2.
Of the 47 included studies, 27 received a GRADE score of "very low" and 20 studies received a GRADE score of "low" (Supplementary Table 1). The summary of the quality assessment for the studies included in the meta-analysis for each study outcome (N = 11; grouped based on multiple diagnostic criteria, sampling method, and definition of patient group prevalence estimation provided by each study, see Methods) also showed GRADE scores of "very low" and "low" ( Table 3).

Endometriosis
Twelve studies reported prevalence estimates of endometriosis diagnosed via laparoscopic surgical visualization, and four out of these 12 reported additional histological confirmation (Figure 3). The pooled prevalence for surgically confirmed endometriosis in population studies, which were validated through surgical records, was estimated at 1.2% (95% CI: 0.9-1.6, range: 0.8-2.4%) (Figure 3A). Two of these studies retrospectively extracted data from large-scale population-based databases in Israel (82) and Middle Eastern women living in Sweden (88). Two further crosssectional studies in Jordan (84) and the U.A.E. (102) assessed women attending universities who could be affected but given the younger age may not have undergone laparoscopic intervention or sought medical help.
The hospital-based prevalence for studies of endometriosis among women undergoing laparoscopy for unspecified indication was 12.9% (95% CI: 4.1-25.4, range: 4.2-21.0%).  However, differences in prevalence estimates were observed based on the availability of healthcare insurance coverage ( Figure 3B). Despite the importance of healthcare insurance coverage to provide cost-effective, quality healthcare services, most of the region did not provide or implement insurance coverage for the citizens and residents until the World Health Assembly passed a resolution in 2005 (30,109,110). Articles from countries that were published before 2006 had limited healthcare insurance coverage with a pooled prevalence estimate of 19.6% (95% CI: 17.5-21.7; range: 18.8-21.0%) (61,86), as opposed to a prevalence estimate of 6.9% (95% CI: 1.7-15.2; range: 4.2-11.0%) (84,102) for articles in countries published after 2007 with highly available private healthcare insurance coverage. Wider healthcare insurance coverage may reflect the lower prevalence estimate for surgically confirmed endometriosis, due to more accessibility to surgical procedures (111). The pooled hospital-based prevalence of endometriosis among infertile women undergoing laparoscopy was higher than for any indication, at 24.9% (95% CI: 5.2-53.0), although study estimates varied widely (range: 5.7-50.3%) (65,66,68) (Figure 3C). One large prospective study in Egypt (N = 2,493) showed that infertility is the primary reason for laparoscopic surgery in 80.9% of surgeries, followed by chronic pelvic pain in 12.2% and other indications in 14.5%. Endometriosis was diagnosed in 38.8, 46.6, and 14.5% of these three groups, respectively (61). This suggests that patients are more likely to seek medical treatment due to infertility compared to pelvic pain or other indications, which may be due to limited access of unmarried women to gynecology clinics. The hospital-based prevalence of endometriosis among women undergoing laparoscopy for pelvic pain was only estimated in a single study, at 12.2% (95% CI: 8.2-17.3) (62) (Figure 3D). The prevalence of endometriosis is likely overestimated among women undergoing surgery for pain symptoms and/or infertility; hence, there is an inherent selection bias in these groups compared to the general population.
Endometriosis was staged laparoscopically according to the four stages of the American Society of Reproductive Medicine (ASRM) staging system in 4 out of 12 studies (61,68,104,112). The laparoscopic presentation of stage I/II vs. stage III/IV endometriosis was noted in one study (66). The endometriosis stage was not mentioned in eight of the 12 studies. Pooled prevalence of endometriosis for patients undergoing laparoscopy for any indication, according to the ASRM staging system, was 21

Uterine Fibroids
Eight hospital-based studies estimated the prevalence of uterine fibroids by retrospectively screening electronic medical records of women (Figure 4). Seven studies utilized hysteroscopy as the diagnostic tool, and only one study utilized imaging and clinical assessment to diagnose uterine fibroids. The pooled hospitalbased prevalence of uterine fibroids in women undergoing hysterectomy or ultrasound was 30.6% (95% CI: 24.9-36.6; range: 18.5-42.6%) for any indication (Figure 4A). The pooled hospitalbased prevalence of uterine fibroids in women undergoing hysterectomy for abnormal uterine bleeding was 57.1% (95% CI: 45.5-68.4; range: 51.0-62.7%) (Figure 4B), while the prevalence of uterine fibroids diagnosed by ultrasound was 21.2% (95% CI: 18.8-23.7).

Adenomyosis
Five hospital-based studies reported the prevalence of adenomyosis by retrospectively screening electronic medical records of women attending a hospital for a hysterectomy (Figure 5). The hospital-based prevalence of adenomyosis in women undergoing hysterectomy for any indication was 30.8% (95% CI: 27.1-34.6, range: 25.5-37.7%) ( Figure 5A) and 47.2% (95% CI: 40.7-53.7, range: 45.7-49.0%) for heavy menstrual bleeding (Figure 5B). Women diagnosed with adenomyosis often have other associated gynecological diseases, such as endometriosis or uterine fibroids, which complicates differential diagnosis and attribution of symptoms. In addition, no study provided an imaging-based diagnosis that could provide a more representative population-based estimate. While the gold standard for diagnosis has been histopathologic examination of the uterus after hysterectomy, the prevalence may be underestimated due to missed adenomyosis from cases that are not managed by hysterectomy (114).

Main Findings
We conducted the first systematic review and meta-analysis of pooled prevalence of PCOS, endometriosis, uterine fibroids, and adenomyosis in women from the Middle East, a region representing 6.8% of the world's population but underserved in clinical science (28)(29)(30)(31). Much of the scientific research featured poorly designed studies and methodological and statistical heterogeneity. The region lacks reliable, population-based data on the major causes of women's health diseases due to limited reporting regulations and lack of national registries (29,31).
Our findings indicate that the population-based prevalence of PCOS according to NIH and Rotterdam diagnostic criteria in the Middle Eastern populations is estimated at 8.9% (95% CI: 6.5-11.7) and 11.9% (95% CI: 7.1-17.6), respectively, which are similar to the estimated global prevalence (5-9% and 10-20%, respectively) (2). However, among women from the Gulf Region, there was a substantially higher prevalence of PCOS (18.8%; 95% CI: 9.5-30.3) in comparison to women from the Levant (6.3%; 95% CI: 4.4-8.6) and Persian Region (6.7%; 95% CI: 4.6-9.1), based on the NIH criteria. Obesity rates in the Arab Gulf countries exceed those of the remaining Middle Eastern region, with a gender disparity among women, for all age groups (115), where the prevalence of overweight and obesity among adults is 35-48 and 24-40%, respectively (116). Obesity is a common clinical feature in women affected by PCOS, due to its association to the onset of oligomenorrhea and hyperandrogenism (117). Comorbid conditions of PCOS, such as hyperinsulinemia, type 2 diabetes mellitus, cardiovascular disease, and dyslipidemia, have also been reported to have the highest prevalence in the Arab Gulf countries (118)(119)(120). Hence, it is likely that the prevalence differences of PCOS between the regions are at least in part due to the pathogenetic role on obesity in the subsequent development of PCOS (117). Analysis of a genome-wide association study (GWAS) on PCOS demonstrated that the relative severity of the PCOS phenotypes, in particular severe hirsute-hyperandrogenism, may  result from different combinations of SNPs more commonly present in women of Middle Eastern origin. This may be a basis for the higher prevalence of PCOS that is dominated by obesity, high blood pressure, diabetes mellitus, and hirsutism (121,122). Genetic influences in populations of diverse origin are important to study alongside environmental influences, to understand the effect of their interaction in causing different PCOS phenotypes (123). Additionally, high heterogeneity was reported due to variability of age group of the participants among studies, where post-menarche adolescent women and post-menopausal women reported a lower prevalence of PCOS compared to pre-menopausal adult women. Adolescents with PCOS manifest similar clinical, metabolic, and endocrine features to adult women (124); hence, the significant difference could be attributed to delayed diagnosis of the condition among young, single women who are unable to access reproductive health care due the hegemony of traditions that may prevent them from discussing their symptoms and seeking care.
Prevalence for surgically confirmed endometriosis (12.9% among women undergoing laparoscopy for any indication; 24.% among infertile women; 12.2% among women hospitalized for pelvic pain; 1.28% in a population-based setting) was similar to European ancestry populations (5-10% among women undergoing laparoscopy; 5-50% among infertile women; 5-21% among women hospitalized for pelvic pain; 2-43% among asymptomatic women seeking tubal ligation) (4,17,125). However, the reliance on surgical confirmation of endometriosis, access to clinics that is mostly limited to married women, and consequent selection biases affect these estimates, as is demonstrated by the heterogeneity estimates in our meta-analyses. As the main presenting symptomatology of endometriosis and mode of diagnosis are both influenced by psychosocial factors, women of different cultural backgrounds may present with different clinical phenotypes. Further epidemiological studies must be conducted among women of different populations, to explore the diagnostic pathways for women with endometriosis and be able to obtain an accurate prevalence estimate for the population. In addition, given that endometriosis has an estimated heritability of ∼50% and the region has an estimated consanguinity rate of 20-50%, increased prevalence of endometriosis may be mediated by numerous deleterious recessive alleles due to increased homozygosity levels (126)(127)(128). Most GWAS datasets have been generated from women of European ancestry, with only two in women of East Asian ancestry. It is important to define the extent of the effects of specific risk alleles in different ethnic groups and conduct trans-ethnic mapping to restrict signal to causal variants of endometriosis (129)(130)(131).
The hospital-based pooled prevalence of uterine fibroids for women was estimated at 28.2% (95% CI: 20.4-36.7), vs. 57.1% (95% CI: 45.5-68.4) among women with heavy menstrual bleeding, which are on the high end of the estimated global prevalence 5-30% (3) and 37-59% (132), respectively. Detection bias may explain the overestimation of uterine fibroid prevalence as nearly all studies were from women presenting for hysterectomy. Considering the consistently observed greater risk of uterine fibroids among black women, it is important to conduct further more robust epidemiological and genetic studies in women of Middle Eastern origin, to investigate whether they also exhibit a higher prevalence and whether this is associated with certain risk factors (3,132,133). The hospital-based prevalence of adenomyosis for women undergoing hysterectomy was high (any indication: 31.7% [95% CI: 20.6-43.9; for heavy menstrual bleeding: 47.2% (95% CI: 40.7-53.7)], but within the range previously reported for studies assessing prevalence at hysterectomy (14-57%) (21). The restriction of hospital-based studies to women undergoing hysterectomy for adenomyosis likely underestimates the prevalence as tissue may not have been routinely investigated for the condition. In addition, prevalence studies of uterine fibroids and adenomyosis all recruited multiparous women in their fourth and fifth decades of life, making comparison of estimates with global figures difficult. The lack of well-conducted, population-based studies limits the understanding of the public health impact of these conditions and prioritize diagnostic and management pathways.

Limitations and Strengths
This is the first systematic review of the prevalence of common gynecological conditions in Middle Eastern women. Study and reporting quality were generally low; however, the moderate/high heterogeneity that were present in the pooled data was reduced after completing subgroup analysis using relevant variables to limit bias. Potential explanations of residual heterogeneity among the studies are likely due to differences in study populations, sampling schemes, and study designs (case definition and ascertainment). Most of the studies selected women through convenience sampling, from hospitals, which may either overestimate the prevalence of the diseases or underestimate the disease risk due to missed asymptomatic cases. Prevalence estimates from retrospectively screened medical records are potentially affected by selection and information biases, as well as methodological issues, such as a lack of specific inclusion and exclusion criteria and data abstraction protocols. Beyond the limitations of the existing literature, there are fundamental issues with the diagnostic method used for the gynecological conditions, which hinders derivation of true population prevalence. The heterogeneous nature of PCOS in terms of its definition, diagnostic criteria, and ethnic variability likely leads to variable PCOS prevalence estimates in different populations. The lack of a non-invasive diagnostic modality for endometriosis creates diagnostic bias for those that are unable to access surgical evaluation. In addition, much of the information available on uterine fibroids and adenomyosis prevalence came from hospital-based studies that lacked imaging and symptomatology-based diagnosis and were not representative of the general population.
Social and cultural factors play a role in diagnostic bias. Given that women in the region will more likely consult a physician for fertility-related issues, as opposed to pain or menstrual irregularities (61), the studies conducted in a hospital-based setting are based on highly selected populations that cannot be generalized broadly. In addition, gynecological conditions and associated clinical phenotypes may present differently in various populations. Given the lack of epidemiological studies in the region focusing on symptomatology and phenotypes, the standard clinical definitions based on mainly Western population health data may not adequately capture the symptom presence and severity affecting diagnostic pathways of these heterogeneous conditions (134,135). In fact, treatment regimens and responses vary widely between regions and among ethnic groups (136). There is an underrepresentation of studies from low-and middle-income regions in the Middle East that have been subject to war and political instability (Iraq, Syria, Libya, Sudan, Lebanon, Yemen, and Palestine), as opposed to higher-income regions, such as the Gulf countries, Turkey, and Egypt, where women have greater access to health care and may be more intensively screened. This review highlights the importance of investigating gynecological health in the Middle East, and the need for welldesigned studies that address both prevalence and the impact of gynecological condition on women's lives. An extensive search was conducted in two languages, to avoid missing any relevant information. We performed a broad search, including manuscripts from gray literature. Potential sources of bias were identified, and significant clinical and statistical heterogeneity was discussed to indicate considerable variability in the data due to residual confounding and study design. It is essential to prioritize improved and unbiased quantification of gynecological condition prevalence and incidence extrapolation, to improve generalizability and improve public health focus.
Further epidemiological studies must be conducted to investigate symptomatology and risk factors in women of this region, to deliver more culturally sensitive healthcare (137). Specific areas in need of attention include improving the clinical definition, diagnostic techniques, and treatment methods to provide the best practice for this diverse patient population. More generally, given the potential effects of these common chronic conditions on personal lives, economies, healthcare systems, and global community, it must be a public health priority to advance our understanding of the complex pathways leading to diagnosis, develop targeted prevention, and provide early detection guidelines in different populations (138)(139)(140)(141)(142)(143). Key to this endeavor is advancing our understanding of how genetic and non-genetic factors interplay to disease predisposition and mechanisms in different populations (144).

CONCLUSION
To our knowledge, this is the first systematic review study to investigate the prevalence of common gynecological diseases in women in Middle Eastern populations, highlighting a paucity in reliable data. With 200 million women in the region, the importance of conducting more research in the area of women's health is clear and is needed to serve as a benchmark for evaluation of future research activities and comparative purposes with Middle Eastern immigrants and other populations. A gynecology clinic in the Middle East remains the realm mostly of married women. Young women may suffer from chronic pain and menstrual irregularities, but the hegemony of traditions may prevent them from discussing these and thus prolong suffering. To continue to decrease health disparities, researchers should acknowledge the limitations in scientific research that investigate the health disparities in women of Middle Eastern region. Robust data will urge policymakers in the Middle East to invest in health information systems to better identify risk factors for gynecology diseases, help set targets for policymaking, impact public awareness, and enable educational and evaluation strategies.

DATA AVAILABILITY STATEMENT
The original contributions presented in the study are included in the article/Supplementary Material, further inquiries can be directed to the corresponding author/s.

AUTHOR CONTRIBUTIONS
MM and NR were involved in all parts of the study: conception, study design, acquisition of data, information extraction, quality assessment, analysis, meta-analysis plots, interpretation, drafting of manuscript, and final approval. KZ and CB were responsible for conception, study design, analysis methods, interpretation, drafting of manuscript, and final approval. SK identified the search terms, developed the search strategies, conducted the search on each database to find relevant studies, reviewed the literature search method section of the manuscript, and did the final approval. MA-J, HA, CL, and SM were involved in study design, interpretation, reviewing of the manuscript, and final approval. All authors contributed to the article and approved the submitted version.