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Dating of the human corpus luteum of menstruation using histological parameters.

The aim of this investigation has been to examine which histological parameters are of value in the dating of the corpus luteum of menstruation. Further to express these parameters in a graphical form which is of practical use for a histological dating. The material comprises histological specimens of the ovaries from 24 women selected according to strongly limiting criteria. The following histological parameters have been found useful for the dating: 1) Extravasated blood and capillaries in the granulosa cell layer. 2) The size of the granulosa cells. 3) Degeneration of the granulosa cells. 4) Invasion of theca cells into the granulosa cell layer. 5) Organization of the central cavity. These parameters have been graded semiquantitatively, and the results have been the basis of the curves prepared by electronic data processing of the observations. Finally some indications for histological dating of the corpus luteum of menstruation are mentioned.