{'fraction_non_alphanumeric': 0.020440251572327043, 'fraction_numerical': 0.020440251572327043, 'mean_word_length': 5.5, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 1, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Magnesium in acute myocardial infarction

EDITOR,—Salim Yusuf and Marcus Flather1 offer no satisfactory explanation for the statistical incompatibility (P>0.0001 for heterogeneity) between the inefficacy of magnesium in the fourth international study of infarct survival (ISIS-4)2 and the clearly positive pooled results of the 10 other trials of intravenous magnesium in acute myocardial infarction. Magnesium has been reported to protect contractile function in a dozen experimental models of myocardial ischaemia and reperfusion and is now known to act during the first few minutes of reperfusion.3 4 ISIS-4 was unique in that most …