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The comparison of several dose levels with a zero dose control.

The comparison of dose treatment means with a control mean to determine the lowest dose level at which there is evidence for a difference from control was discussed recently (Williams [1971]). A test procedure was proposed for the case when all treatments are equally replicated. The primary purpose of this paper is to give results which enable the test to be used when the treatment replications are unequal. A two-sided version of the test is also described and the Type I errors of the test are discussed.