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Type III Mixed Cryoglobulinemia Associated with Digital Necrotic Ulcer Successfully Treated with Intermittent Intravenous Pulse Cyclophosphamide

Cryoglobulinemic vasculitis is an immune complex-mediated vasculitis predominantly affecting small vessels. The authors report an 18-year-old woman with painful digital necrotic ulcer due to type III cryoglobulinemic vasculitis on the basis of systemic lupus erythematosus. Serum protein electrophoresis and immunoelectrophoresis demonstrated a polyclonal peak of the immunoglobulin Gλ (IgGλ) and IgMλ type. The patient was successfully treated with intermittent intravenous pulse cyclophosphamide.