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Calcium antagonists in hypertension

December and all were in the City Hospital alone. Five of these patients died within the next two months. During the same period there were three patients in whom the initial antibody titre was high (256 or greater) and who died within a few days of the onset of symptoms. An additional four patients (one asymptomatic) were subsequently found to have high initial titres that remained raised, and of these only one survived a further nine months, by which time his respiratory syncytial virus titre had fallen to a quarter of its original level. Isolation of the virus was achieved in only one case. During the same study we detected small epidemics of influenza A and B and in comparison the cases of respiratory syncytial virus tended to have a more prolonged illness; wheezing was a frequent feature, while sore throat was not. None of the cases with only viral infection had either clinical or radiological evidence of pneumonia (this contrasts with 87 out of 192 reported to the Public Health Laboratory Service (26 November, p 1618), though two patients who had proved additional bacterial infection did have signs and radiological evidence of consolidation. This outbreak of respiratory syncytial virus infection was confined to one hospital and all the proved cases occurred within a four week period. A repeat prospective study carried out over the winter of 1982-3 showed only one case of respiratory syncytial virus infection (this patient died) and 10 cases of proved influenza A. We conclude that respiratory syncytial virus infections in the elderly are associated with appreciable morbidity and mortality.