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Heterozygosity of F2 from two segregating populations.

Exact formulas that predict the average inbreeding coefficient and heterozygosity of an F2 generation derived from two segregating populations were developed. When population sizes are sufficiently large, the heterozygosity of the F2 is one-half of the heterozygosity of F1 plus one-half of the mean heterozygosity of the two parental populations. The importance of inferring heterozygosity of F2 is discussed from evolutionary perspective.