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Clinical Clues to Avoid Missing Melanoma When Morphology is Not Enough.

1. Melanoma can be missed not only when the lesion is lacking specific morphologic clues, but also when the lesion is localized on covered areas and the patient is not undressed by the clinician. 2. When morphologic criteria to diagnose melanoma are lacking, there are 5 particularly relevant clinical clues to be considered, in order to avoid the risk of leaving a melanoma untreated. 3. Once the lesion is excised, melanoma could still be missed if a careful clinico-pathologic correlation is not carried out.