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[Biotransformation and pharmacokinetics of bamipine in rats. 2. Pharmacokinetics (P 2)].

After oral application pharmacokinetic parameters of N-phenyl-N-benzyl-4-amino-1-methylpiperidin (bamipine) were investigated. The curve of the plasma level is characterized by two maxima. If the first maximum is neglected, the calculated elimination half-life is 9.52 h, the invasion half-life 1.03 h. The first maximum is calculated as a lag-time (1.62 h). By whole-body radiography of the animal an accumulation of activity was determined in the glandular tissues behind the eye--beside the usual accumulation of activity in liver, spleen, kidney and lung.