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Human T cell lines with antigen specificity and helper activity

Human T blasts, obtained by stimulation of peripheral blood mononuclear cells (PBM) with tetanus toxoid, diphtheria toxoid or Candida albicans, were expanded in long‐term culture using alternate periods of antigen restimulation and growth in media containing interleukin 2. The cells gave a proliferative response only to the antigen originally used for stimulation. Such a response was strictly dependent upon the presence of autologous but not of allogeneic mitomycin C‐treated mononuclear cells. When added to autologous PBM depleted of E‐rosetting cells together with the specific antigen, the T blasts induced a polyclonal proliferation and differentiation of B cells. Allogeneic B cells were activated by antigen‐stimulated T blasts only in the presence of irradiated mononuclear cells autologous to the responding T blasts.