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Discovering an overlooked fact in atrial fibrillation: Iron deficiency.

We read the article titled “Iron deficiency and hematinic deficiencies in atrial fibrillation: A new insight into comorbidities” in the current issue with great interest and curiosity.[1] First of all, we would like to congratulate the authors on this novel study. They analyzed an unexamined topic in patients with nonvalvular atrial fibrillation (AF). Despite the similar underlying inflammatory mechanisms and close relationship between heart failure (HF) and AF, previous studies were usually only related to iron deficiency (ID) in patients with HF. A review of the literature review indicated that ID has not previously been evaluated in AF patients, regardless of valvular etiology.