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A Ruthenium Catalyst with Simple Triphenylphosphane for the Enantioselective Hydrogenation of Aromatic Ketones

An efficient Ru catalyst constructed from simple and commercially available triphenylphosphane and enantiopure (1S,1′S)‐1,1′‐biisoindoline (BIDN) was applied to the asymmetric hydrogenation of aromatic ketones. A range of simple aromatic ketones could be hydrogenated with good to excellent enantioselectivities (up to 95 % ee). An appropriate enantioselective transition state was proposed to explain the high enantioselectivity obtained with this catalytic system. This study represents the first example to establish a practical Noyori‐type catalyst with a simple achiral monophosphane for highly enantioselective hydrogenation.