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[Percutaneous permeability study for patches Shangshi Zhitong on different kinds of bases].

OBJECTIVE
To study the percutaneous permeability of patches Shangshi Zhitong on different kinds of bases with the permeation percentage of brucine, strychnine and atropine.


METHOD
Using modified Franz difusion to investigate the penetration quantity of brucine, strychnine and atropine. The contents of brucine, strychnine and atropine were determined by HPLC.


RESULT
The average accumulative permeation percentage of brucine, strychnine and atropine on new base were 53.25%, 74.52% were 34.32%, respectively, and on old base are 54.90%, 50.24%, 46. 54%, respectively.


CONCLUSION
The new base benefits the lipophilic drugs and releases more stably.