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DETECTION OF HUMAN PAPILLOMAVIRUS-21 GENOTYPES IN A SAMPLE OF IRAQI WOMEN WITH CERVICAL ABNORMALITIES AND CANCER

To determine the prevalence and genotypes of cervical HPV infection in Iraq by newly developed technique. In this study, 188 women with cervical dysplasia (CIN I, II/III), 7 women with squamous cervical cancer, 40 women with atypical squamous cell and cervicitis and 25 healthy women as control group were collected. For Detection of HPV types, DNA extracted from cervical exfoliated cells was evaluated by polymerase chain reaction and typing with genoarray test. HPV-DNA positive was found 28.94% (68/235) in the cases but was absent in the control group. In the cases, the detection rate of HPV DNA in cytological categories atypical squamous with chronic cervicitis, LSIL (CIN I), HSIL(CIN II-III), and cancer was 5% (2/40), 30.34% (44/145), 34.88%(15/43), and 100%(7/7), respectively. Seventeen different HPV genotypes were investigated among 68 infected women. Moreover, ten different HPV for the first time in Iraqi women were recorded. Our finding demonstrated a predominance of HPV-59 (14.4%) followed by HPV-16 (13.3%) of all infection, but HPV-16 the most common type in HSIL and cancer was observed. Our results provide evidence the genoarray using for detection was increasing the number of isolates. Since 28% of infected women had HPV-16 and -18, the HPV vaccine is importance to introduction. Moreover, HPV-16, 45 and -18 were highly associated with increasing severity of the disease, thus the strongest risk factor for persistence of infection was the presence of these types.