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Ketamine hydrochloride in the laboratory rat

There are a number of published reports on the use of ketamine hydrochloride in the rat. Weisbroth & Fudens (1972) found that ketamine at a dose level of 44 mg/kg produced a 'level of anesthesia' sufficient for a procedure lasting 10-15 min, such as cardiac puncture, laparotomy, or skin grafting. Smith & Castro (1978) said that anaesthesia could be induced, using ketamine hydrochloride at a dose rate of 20 mg/kg, sufficient to allow laparotomy and the construction of Thiry-Vella loops. However, according to Green (1979) experience in rats has been very variable. We wish to report our experience with the use of this anaesthetic. Adult female albino Wi star rats, body weight 190240 g, were given ketamine hydrochloride ('Vetalar';