{'fraction_non_alphanumeric': 0.039780521262002745, 'fraction_numerical': 0.019204389574759947, 'mean_word_length': 5.697247706422019, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Synthesis of the monomeric unit of the lomaiviticin aglycon.

Reported in 2001, lomaiviticins A (1) and B (2, Figure 1) were isolated from Micromonospora lomaivitiensis and demonstrated striking molecular architectures and impressive antitumor and antibiotic activities against a variety of cancer cell lines and bacteria,[1] apparently exerting their action through a novel mechanism involving DNA cleavage.[2] Their chemical synthesis presents a formidable challenge, and reports describing partial solutions have already appeared.[3] In this communication, we describe the total synthesis of the monomeric aglycon unit (3, Figure 1) of the lomaiviticins, which is reminiscent of the kinamycins (i.e. kinamycin C, 4, Figure 1).