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Assay procedures for polyamines in urine, serum, and cerebrospinal fluid.

Putrescine (1,4-diaminobutane) and the polyamines spermidine and spermine have attracted interest as possible markers of malignancy and of response to chemotherapy. The assay methods currently in use for these amines are reviewed and compared in respect to sensitivity, reproducibility, and applicability to routine analysis for them in urine, blood, and cerebrospinal fluid.