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The suprachiasmatic nucleus drives day–night variations in postprandial triglyceride uptake into skeletal muscle and brown adipose tissue

What is the central question of this study? What are the factors influencing day–night variations in postprandial triglycerides? What is the main finding and its importance? Rats show low postprandial plasma triglyceride concentrations early in the active period that are attributable to a higher uptake by skeletal muscle and brown adipose tissue. We show that these day–night variations in uptake are driven by the suprachiasmatic nucleus, probably via a Rev‐erbα‐mediated mechanism and independent of locomotor activity. These findings highlight that the suprachiasmatic nucleus has a major role in day–night variations in plasma triglycerides and that disturbances in our biological clock might be an important risk factor contributing to development of postprandial hyperlipidaemia.