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THE STIMULATORY EFFECT OF NEUROTENSIN ON COLONIC MOTILITY IS MEDIATED VIA NERVOUS PATHWAYS

Previously presented studies support the view that effects of neurotensin in live are dependent to a great extent on an intact nervous system.' Thus, pentagastrin-stimulated gastric acid secretion is inhibited by neurotensin in vagally innervated, but not in denervated, fundic pouches in dogs.' Similarly, truncal vagotomy decreases the sensitivity of neurotensin to inhibit gastric emptying and transit of gastrointestinal contents in rats.:' Moreover, the effect of neurotensin on the activity front of intestinal motility complexes is blocked by hexamethonium and atropine in rats.' In the present study, the ability of neurotensin to stimulate the motility of the proximal colon in the cat" has been further examined by application of various blocking agents. The aim was to clarify whether the stimulation of the motility is mediated via nervous pathways or by a direct action on colonic smooth muscle.