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Spatiotemporal expression patterns of mammalian chordin during postgastrulation embryogenesis and in postnatal brain

Chordin is an antagonist of TGFβ‐like bone morphogenetic proteins (BMPs) that plays roles in dorsoventral axis formation and in induction, maintenance and/or differentiation of neural tissue in early vertebrate embryogenesis. In contrast, little is known concerning possible roles for Chordin at later stages of vertebrate development and in the adult. To provide insights into possible postgastrulation roles for Chordin, we report the spatiotemporal expression patterns of Chordin in 8.5‐ to 15.5‐dpc mouse embryos and in the postnatal mouse brain. Expression of Chordin in the primordia of most major organs from 10.5 dpc, including the brain, lung, heart, liver, kidney, thymus, and gut, suggests multiple functions for Chordin in organogenesis, potentially by means of interactions with TGFβ‐like BMPs. The relatively high levels of Chordin expression in condensing and differentiating cartilage elements from 11.5 dpc indicates a generalized role for Chordin throughout embryonic skeletogenesis. In the postnatal mouse brain, we demonstrate that Chordin is coexpressed with other components of the TGFβ‐like BMP signalling pathway in the cerebellum and hippocampus, sites of high synaptic plasticity, suggesting a role for Chordin in this process. Dev Den;217:449–456. © 2000 Wiley‐Liss, Inc.