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Endothelin-B receptor stimulation in porcine coronary resistance arteries

AIM:To Study the relative role of ET B receptor stimulation in porcine coronary resistance arteries.METHODS:Isolated porcine coronary resistance arteries were studied using in vitro videomicroscopy. Dose-response curves to the ET B agonist sarafotoxin 6c (SF6c) were determined under control conditions,after endothelial denudation or after 10 5 mol/L L-NAME.RESULTS:In control vessels,SF6c caused a weak vasodilation that followed a constriction. After endothelial denudation or blocking NO synthase with L-NAME, however, the vasodilation effects of SF6c did not appear except the dose-dependent constriction.CONCLUSION:The weak vasodilation and vasoconstriction can be induced by endothelin-B receptor stimulation in coronary resistance vessels, and the effect of relaxation of coronary resistance arteries due to ET B receptor stimulation is dependent on endothelium and mediated by NO.