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Alcohol‐Mediated Dysregulation of Histone Deacetylases Decreases Myoblast Differentiation in SIV‐Infected Male Rhesus Macaques

Loss of functional metabolic muscle mass remains a strong and consistent predictor of mortality among people living with HIV (PLWH). PLWH have a higher incidence of alcohol use disorder (AUD) and myopathy is a significant clinical comorbidity due to AUD. Skeletal muscle mass maintenance, repair and regeneration are mediated by proliferation and differentiation of satellite cells (myoblasts). Previously we demonstrated that chronic alcohol decreases satellite cell myogenic gene expression and differentiation. The aim of this study was to determine whether alcohol‐mediated epigenetic dysregulation, specifically an increase in Class IIA histone deacetylases (HDACs), mechanistically contributes to the decreased differentiation potential of satellite cells.