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Bacterial profile and antibiogram of urine culture isolates in a teritiary care center

Introduction: Urinary tract infections (UTI) are the commonest infections, where people from all age groups including children to older age individuals experience in their life time. Though several microorganisms are attributed as causative agents of UTI like fungi, viruses, bacterial infections are responsible for > 95% of UTI cases. Untreated UTI can lead to high morbidity and long term complications like renal scarring, hypertension and chronic kidney diseases. There is diversity among uropathogens regionally and gradually becoming more and more difficult to treat leading to therapeutic dead end. And also because of evolving antibiotic resistance phenomenon among uropathogens, regular monitoring is utmost important to provide guidelines for empirical antimicrobial therapy. Materials and Methods: This is an observational study carried out in the department of Microbiology in Santhiram Medical college and General hospital for a period of three months from January 2019 to March 2019. A total of 550 midstream urine samples were processed from patients of all age groups with suspected UTI symptoms. Urine culture was done by semi quantitative technique. Results of urine culture were detected as significant and insignificant based on standard Kass criteria. A growth of >=105 colony forming units (CFU)/ml is considered as active UTI with significant bacteruria. Cultures having more than three types of colonies were considered as contaminants. Pathogenic organisms were identified by Gram stain, motility testing and biochemical reactions as per standard microbiological techniques. The antimicrobial sensitivity testing was done by Kirby-Bauer Disc diffusion method. Results: A total of 550 urine samples were analysed, out of which 192(34.9%) samples were found to have significant bacteriuria and the rest 358 (65%) were either non significant bacteriuria or having very low counts of bacteria or sterile urine. Among the 192 positive samples, 125 (65.1%) were from females and 67 (34.8%) were from males. Predominantly Gram negative bacteria (79.1%) were isolated among culture positive samples followed by Gram positive bacteria (13.0%) and fungi i.e. Candida (5.7%). © 2020 Published by Innovative Publication. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by/4.0/)