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Levels in Crohn's Disease

Crohn's disease (CD) is associated with an activation of macrophages. TNF-a and IL-6 are produced by macrophages and their serum levels seem to be increased in active CD. However results remain controversial. Soluble TNF-a receptor (sTNF-aR) serum level has never been evaluated in CD. Th7e aim of our study was to measure the IL-6, TNF-a and sTNF-aR serum levels in active and inactive CD and to compare it with normal controls. We measured by ELISA the IL-6, TNF-a and sTNF-aR serum level in 26 patients with inactive CD (CDAI < 150), 32 patients with active CD (CDAI > 150) and 80 normal controls. Results were compared using a t-test of Student (significant difference if p < 0.05). Results: