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The influence of vascular space involvement on the prognosis of patients with stage IB cervical carcinoma

There is controversy over the question of whether the involvement of vascular spaces influences the prognosis of patients with carcinoma of the uterine cervix. The aim of the current study was to compare patterns of vascular space involvement determined by hematoxylin and eosin (H & E) staining with those patterns determined by immunostaining for factor VIII‐related antigen (F8‐RA) with regard to their prognostic impact on the disease free survival (DFS) and overall survival (OS) of patients with clinical Stage IB cervical carcinoma. Staining for F8‐RA is known to highlight blood vessels predominantly, whereas the presence of tumor cell emboli in vascular spaces of H & E‐stained sections mainly indicates lymphatic vessel invasion.