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Realtime Detection, Quantification, Warning, and Control of Epileptic Seizures—The Foundations of a New Epileptology

The aim of abating seizures in a spatio-temporally selective manner is not a modern one. As early as 150 AD, Pelops from Alexandria, the teacher of Galen, was reported to have aborted what would likely be referred to today as ‘a simple partial seizure with sensory-motor manifestations’ by tying a ligature around the affected limb at the time of the appearance of the first paroxysmal manifestation. Brown-Sequard, Jackson, and, later, Gowers, who coined the term ‘counter-irritation’ to denote a strategy to abate seizures, reintroduced the notion of contingent therapy in the 19th century, an objective that since then and until recently was ignored. After nearly two millennia, the seminal tasks of automated seizure detection and contingent warning and delivery of therapy endowed with realtime feedback capabilities are finally not only feasible but also possibly safe and efficacious. This substantive advance, which at this juncture is in an ‘embryonic’ developmental stage, attempts to address the lack of efficacy of systemically administered pharmacological agents in a large group of patients with epilepsy, together with the relatively high incidence of serious idiosyncratic or intolerable dose-dependent adverse effects, including exacerbation of seizures, and to decrease the risk of injury and the psychosocial burden resulting from their unpredictability. The medical, psychosocial, and economic benefits that will be derived from achieving these objectives are salutary and self-evident to patients, their care-givers, and healthcare providers.