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[Interrelation between the enzyme activity indices and the status of the uterine-placental blood flow in pregnant women at high risk for perinatal pathology].

The aim of the present study was to examine metabolic processes in pregnant women with high risk of perinatal pathology during disturbance in the uterine-placental blood flow (UPF). We determined the following parameters for evaluation of the metabolic disturbances: alanine aminotransferase, hydroxybutyrate dehydrogenase, lactate dehydrogenase, creatine phosphokinase, alkaline phosphatase, thermostable alkaline phosphatase, oxytocinase and lipid peroxidation. The analysis of the obtained data showed that reduction in UPF, limited only in the region of the large uterine-placental blood vessels, was accompanied by a reduction in the activity of HBDH, LDG, CPC, but moderate increase in the whole uterine-placental blood bed was accompanied by the intravillous space, was accompanied by a moderate increase in HBDH, ADG, CPC and AP in comparison with pregnant women without disturbance in UPF, which however occurred in smaller activity of these enzymes both in disturbance in blood flow of intervillous space and in the region of the large uterine-placental blood vessels. These changes as a whole characterized borderline state of energetic metabolism in the organism of the pregnant woman, which in the final analysis assured comparatively favourable outcome of the pregnancy for the fetus.