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Ethics of placebo-controlled trial in severe mania.

A letter raising questions about this study has been submitted to the British Journal of Psychiatry. It was also felt that the journal should carry a discussion on this subject. We therefore publish here a comment on the study itself, raising specific questions about the trial. This is followed by a comment on ethical issues in placebocontrolled trials in general. Finally, the corresponding author of the study has been invited to respond. Editors