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Incorporation of Curcumin in Bilayer Matrices to Reduce the Toxic Effects to Be Used for Wound-Healing Application

Introduction: The self-assembly of hydrophobically modified polymers has become a research hotspot. Chronic, non-healing wounds place a significant burden on patients and healthcare systems. Objective: The present work aims to create a poly (3hydroxybotyrate) (PHB) composite film containing curcumin that would effectively improve skin wound healing by antibacterial activity. Methods: The PHB/curcumin films are devised using a solution casting method, and Chloroform is the main solvent in the work. FTIR spectroscopy analysis is used to prove the success of the insertion process between Cur and the PHB matrix. Results: The PHB/Curcumin film product is smooth and flexible without any defects. Long-term protection is provided by the composite film's sustained curcumin release. Within 15 hours, almost 90% of the curcumin in PHB/Curcumin films is released in a sustained way. Results from the MTT assay show that PHB/Curcumin film has lower cytotoxicity than that of free curcumin. Furthermore, Vivo experiments reveal that the PHB/Curcumin Films have a 95% healing rate and mature epithelialization on day 14 following surgery. Conclusion: Due to the success of loading curcumin in a PHB film and proving the growth in the effectiveness of the method by increasing and prolonging the effect of the biological activity as an antibacterial and in helping tissues to heal wounds in addition to its rapid wound-healing effects, it could be concluded the study considers PHB/Curcumin films promising as a wound dressing agent in wound management.