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Expression of a cytoplasmic LINE-1 transcript is regulated in a human teratocarcinoma cell line.

The major primate family of highly repeated, long interspersed DNA sequences (LINE-1, previously Kpn I, family) includes several thousand 6-kilobase-pair long units that terminate in an A-rich stretch. Recent evidence indicates that long open reading frames occur in at least some family members. These results suggested that one or more LINE-1 family members might be structural genes. Accordingly, a variety of human cell lines was analyzed for the presence of a cytoplasmic, polyadenylylated RNA homologous to LINE-1 sequences. Such a transcript was detected in a human pluripotent teratocarcinoma cell line (NTera2 clone D1). The RNA is approximately 6.5 kilobases long and is homologous to the LINE-1 strand with the open reading frames. The abundance of the transcript varies markedly with previously described variations in the phenotype of these cells and is highest when the cells display the embryonal carcinoma morphology. This RNA may represent a mRNA transcribed from one or more functional genes in the LINE-1 family.