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[Mechanisms of metaplasia of the ductal epithelium of organs of the pancreatico-biliary system].

It has been established in experiments on young rats that during induction of canalicular hypertension or introduction into the ducts of a little tube made of aluminium foil, the ductal epithelium undergoes metaplasia of the intestinal type in the absence of marked inflammatory lesions. In the process of metaplasia there appear loci of proliferation due to the involvement of precursor cells and prolongation of the phase of DNA synthesis. Such mechanisms are likely to underlie the development of precancerous conditions.