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Effects of Dibutyryl Cyclic AMP and Propranolol on Renin Secretion in Dogs

Summary The effect of cAMP and DbcAMP on renin secretion and renal he-modynamics was studied in anesthetized dogs. The infusion of cAMP into a renal artery failed to increase renin secretion significantly, but DbcAMP caused a significant increase in renin secretion. Both cAMP and DbcAMP had a vasodilator effect on renal vessels, without any change in renal blood pressure. These two compounds, however, differed in their effects on GFR and urine flow. cAMP infusion transiently decreased GFR, without significant effects on urinary flow and urinary sodium excretion, but DbcAMP increased GFR, urinary flow, and urinary sodium excretion. Time course studies, however, indicated that there was no direct relationship between renin secretion and RBF or urinary sodium excretion during DbcAMP infusion. The β-adrenergic blocking agents, propranolol and sotalol, decreased both arterial and renal venous PRA, but failed to affect the DbcAMP-induced renin secretion. These findings suggest that the effect of DbcAMP on renin secretion is associated with its action on JGC and not with electrolyte or renal hemodynamic changes. The authors express thanks to Ms. Sharon Hallabrin for her clerical assistance.