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Statistical methods for paired comparisons of SPECT brain images

We develop and apply several straightforward statistical tools--analyses of rigid body motions, linear deformations, and morphological operations (histogram equalization, dilation, medial axis transform)--to single photon emission computed tomography (SPECT) images arising in the clinical investigation of brain lesions. Examples derive from a simulation of relevant clinical features using a physical head phantom and with paired SPECT images of the same patient recorded over time.