{'fraction_non_alphanumeric': 0.037884767166535126, 'fraction_numerical': 0.01973164956590371, 'mean_word_length': 5.780748663101604, 'pattern_counts': {'":': 0, '<': 1, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
The Gamma-Glutamyltransferaselsoenzyme Pattern in Serum as a Signal Discriminating between HepatobiliaryDiseases , IncludingNeoplasias

We have used the gamma-glutamyltransferase (GGT) isoenzyme pattern in serum as a means fordiscriminating between hepatobiliary diseases, including neoplasias. The reference pattern, determined in 142 normal subjects with a simplified conventional cellulose acetate electrophoretic procedure, contained two GGT bands, alpha1-GGT and alpha2GGT, in proportions of 60-80% and 20-40%, respectively. Sera from 95 hepatobiliary patients showed typical isoenzyme features: (a) a beta-migrating GGT form that was <10% of the total GGT in chronic hepatitis and cirrhosis, and 30% of the total GGT in cirrhosis with intrahepatic cholestasis and in cases of extraand intrahepatic obstructive jaundice, including liver neoplasias; (b) a gamma-migrating GGT band and (or) a “dep-GGT” (nonmigrating) band in cases of extrahepatic jaundice; and (c) an albumin-migrating GGT band that had a diagnostic sensitivity of 75% for hepatic tumors. The diagnostic specificity of this last band is 92% toward other hepatic disorders and 91% toward nonhepatic neoplasias; we consider it a potential specific marker for primary or metastatic liver neoplasias.