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ADAM‐mediated amphiregulin shedding and EGFR transactivation

Introduction:  The ectodomain shedding of epidermal growth factor receptor (EGFR) ligands, such as amphiregulin (AREG), by ADAMs (A Disintegrin And Metalloproteases) can be stimulated by G protein‐coupled receptor (GPCR) agonists. Interactions between the CXCR4 GPCR and the CXCL12 chemokine have been shown to mediate gene transcription and cellular proliferation in non‐transformed and transformed prostate epithelial cells, as well as motility/invasiveness in transformed cells.