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THE IMP DEHYDROGENASE CATALYSED REACTION IN ERYTHROCYTES OF NORMAL INDIVIDUALS AND PATIENTS WITH HYPOXANTHINE GUANINE PHOSPHORIBOSYLTRANSFERASE DEFICIENCY

This paper deals with a preliminary investigation concerning the possible mechanisms causing an aberrant purine nucleotide pattern in erythrocytes of hypoxanthine guanine phos phoribosyltransferase deficient individuals (Lesch‐Nyhan Syndrome). The AMP deaminase inhibitor 2,3 DPG has been found to be also a strong inhibitor of IMP dehydrogenase obtained from normal erythrocytes. IMP dehydrogenase from HGPRT‐ase deficient erythrocytes, however, showed a complete hensitivity for this inhibition.