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USE OF NUCLEAR ROUNDNESS AS A COMPLEMENTARY METHOD FOR DIFFERENTIATION OF BENIGN FROM MALIGNANT CANINE MAMMARY GLAND EPITHELIAL TUMOUR ON CYTOLOGIC SMEARS

A fine-needle aspiration biopsy (FNAB) was performed on thirty-eight spontaneous canine mammary gland epithelial tumours (adenomas (n=8), fibroadenomas (n=8) tubulopapillary carcinomas (n=9), solid carcinomas (n=6) and anaplastic carcinomas, (n=7). The neoplastic cells were fixed immediately with Merckofix  spray (Merck  , Darmstadt, Germany) and stained with Hemacolor  (Merck  , Darmstadt, Germany). The digitalized images of each cytologic finding were captured for image analysis. Computer-assisted morphometry of randomly selected nuclei was performed and the values of the morphometric parameter nuclear roundness were assessed. The analysis of data revealed significant differences between benign and malignant tumours (p < .001, ANOVA/LSD test). The results indicate that morphometric parameter nuclear roundness could be used as a complementary method for differentiation of benign from malignant canine mammary epithelial tumours on cytologic smears.