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Pharmacokinetics of the S‐ and R‐enantiomers of aminoglutethimide in saliva of breast cancer patients: Correlations with plasma

The development of sensitive analytical techniques such as HPLC and enzyme immunoassay have permitted measurement of very small quantities of drugs in biological fluids. These techniques have been applied to measure drug concentration in human saliva mainly because it is easily accessible by noninvasive methods and has an extremely low protein content compared with plasma. Thus saliva is suitable for indirectly measuring free drug concentrations in plasma in cases where the salivary drug concentration has been shown to be predictably related to the free drug concentration in plasma. Although a preliminary study in man detected the aromatase inhibitor aminoglutethimide (AG) and one of its metabolites, acetyl aminoglutethimide (AcAG) in saliva, there has been no systematic study of this aspect of the disposition of the drug.