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Conformal Coating of Small Particles and Cell Aggregates at a Liquid‐Liquid Interface

ABSTRACT: Polymer encapsulation of allogeneic or xenogeneic tissue is under active investigation as a means of isolating transplanted cells, such as pancreatic islets, from the immune system. We report here a method for coating small particles and cell aggregates with a very thin water insoluble hydroxyethyl methacrylate‐methyl methacrylate (HEMA‐MMA) membrane that conforms to the shape of the aggregate, and minimizes the polymer's contribution to the total transplant volume. Cell aggregates were coated at a liquid‐Liquid interface of a discontinuous density gradient composed of both aqueous and organic liquids. By increasing the viscoisty difference and decreasing the density difference between the two liquies of the coating interface, coatings from approximately 1 to 15 μm thick were fpr,ed. Aggregates of HepG2 cells and pancreatic islets were coated and remained viable.