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An analysis procedure illustrated on a triple linkage of use for prenatal diagnosis of myotonic dystrophy.

Diagnosis of a number of simple genetic conditions in man is now feasible prenatally (Nadler, 1971 and others) hence, for the first time, parents sometimes have the opportunity of requesting a selective abortion. For those simple genetic conditions that cannot be so diagnosed by direct means, indirect diagnosis through the prenatal phenotype for a marker locus known to be linked to the disease locus (Edwards, 1956; Renwick, 1969), is a useful substitute with potentially wide applicability. A special case is the use, in certain families, of the chromosomal sex of the embryo to give a 50% or 0% prognosis of haemophilia for male and female respectively. Attention is now drawn to an autosomal linkage between the myotonic dystrophy locus (Dm) and the ABH secretor locus (Se) that can be used in favourable circumstances to predict fairly accurately the outcome of a particular pregnancy in a family with this dystrophy. A method of three-locus analysis was required in this work because an additional locus, Lu (for the Lutheran blood group), was involved. Much of the present report concerns an extension-very suitable for this purpose-of a standard Bayesian two-locus analysis (Renwick, 1969, based on Smith, 1959).