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BACTERIAL DENTAL PLAQUE IS AN INDEPENDANT PREDICTOR OF AORTIC STIFFNESS IN POPULATION-BASED SAMPLE: PP.8.310

Background: Pulse wave velocity, a classical index of aortic stiffness has been associated with innate immunity against gram negative bacteria in humans. The aim of the study was to analyze the relation between oral status and aortic stiffness in a large sample of apparently healthy subjects. Methods: 255 subjects aged 35–74 years randomly selected from the polling lists recruited by the Toulouse MONICA centre between 2006 and 2007 were included. Demographic characteristics, lifestyle habits were recorded. Carotid-femoral pulse wave velocity (PWV) and blood pressure were measured. In all subjects, the 28 teeth were examined at 4 sites per tooth: mesiobuccal, midbuccal, distolingual and midlingual by the same experienced clinician throughout the study. Attachment loss (AL), periodontal pocket depth (PD) were measured (mm). Dental plaque (DP) and gingival inflammation (GI) were graded from 0 to 4. AL, PD, DP and GI indexes were calculated as the sum of. AL, PD, DP and GI divided by the number of erupted teeth. Results: All data were available in 252 subjects (57.8 ± 9.5 years, 138 men). Periodontitis was present in 156 (62%) patients. Pulse wave velocity was of 12.35 ± 3.29 m/s. In univariate analysis, PWV was correlated with PD GI, AL and DP indexes (p < .01). After adjustment for age, sex, systolic blood pressure, education level, physical activity, smoking status, c reactive protein and body mass index, only dental plaque index (p = .02) was associated with PWV. Conclusion: The current data showed that dental plaque was linked with aortic stiffness. This study suggests that oral health improvement may result in beneficial change in arterial haemodynamics in the population.