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Hematologic Predictors Of Outcome In Carotid Endarterectomy.

Introduction Neutrophil-to-lymphocyte ratio (NLR) and platelet-to- -lymphocyte ratio (PLR) are useful markers for identifying inflammation, which is a common feature of atherosclerosis. Patients with carotid atherosclerosis are at greater risk for cerebrovascular events which cause significant morbidity and mortality. Objectives The aim of this review was to determine the prognostic ability of the NLR and the PLR in patients undergoing carotid endarterectomy (CEA). Materials and Methods A search was performed in Medline, Scopus and ISI web of knowledge in order to identify articles focused on these hematological parameters and their impact on the outcomes in patients undergoing CEA. The 30-day stroke and stroke/ death rates were retrieved. Additional demographic data was meta-analysed. Results Platelet-Lymphocyte ratio was associated with an increased 30-day stroke rate. Additionally, an increased PLR was associated with symptomatic internal carotid artery stenosis and postoperative acute coronary syndrome in patients who underwent CEA. An elevated NLR was associated with an increased risk of cognitive dysfunction one day after CEA. Conclusions The NLR and PLR have prognostic value for carotid endarterectomy in the short term.