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Growth of Children with Primary Hypothyroidism on Treatment with Respect to Different Ages at Diagnosis

One hundred and thirty-seven (90F, 47M) children with CPH were included in the study. The age of diagnosis ranged between 13 days and 5 years and the follow-up period from 2.3 to 18.2 years. The patients were divided into three groups according to the age of diagnosis: Group 1 (n = 42), diagnosed between 0-3 months of age (mean age 0.1 ± 0.3 years); Group 2 (n = 53), between 3-12 months of age (mean age 0.5 ± 0.6 years) and Group 3 (n = 42), after 12 months of age (mean age 1.5 ± 3.9 years). The anthropometric and laboratory data obtained from the files were recorded at 6 monthly intervals between 0 and 2 years of age and at yearly intervals thereafter. Weight and height measurements of each visit and calculated body mass index (BMI) were expressed as SDS. Bone ages of the patients evaluated by the Greulich and Pyle method were recorded at annual intervals. At each age group, the difference between chrono-