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The brain in Gaucher's disease.

To the Editor. —In the article by Daniels et al, 1 enzymatic studies of brain samples from patients with Gaucher's disease are described. The authors either missed or ignored references to our research, which describes studies of brains from patients with Gaucher's disease. In 1980, Soffer et al 2 described involvement of the CNS in adult-onset Gaucher's disease. In one of their patients, typical Gaucher's cells with characteristic storage material were found throughout the brain and in the leptomeninges. They were confined to the perivascular space of small blood vessels and were commonly associated with an intense perivascular, gliomesodermal fibrillary reaction. Daniels and co-workers 3 stated that their patient had no discernable Gaucher's storage cells in the brain. They offered no comment on the differences between their and others' findings in adults with Gaucher's disease. The authors also stated that no enzymatic studies had previously been reported for the brain of