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MICROFABRICATED DEVICE FOR CONTROLLED STIMULI OF PRIMARY CILIA

We present an improved device and method for studying cellular response on microfluidic controlled stimuli of primary cilia. The primary cilium functions as a mechano-sensor in renal tubular epithelium. Malfunction of cilia has been implicated in polycystic kidney decease as well as other kidney abnormalities. Bending of cilia will give rise to an intracellular calcium signal (1,2,3), but little is known about the importance of flow direction, magnitude and duration to the calcium response. Our preliminary results indicate flow speed sensitivity.