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Bilateral Secondary Mucinous Adenocarcinoma of Thyroid: Case Report

Metastatic adenocarcinoma to the thyroid gland, though not uncommon in autopsies, is rarely encountered in clinical practice. Tumors of breast, kidney, or lung and melanomas are occasionally sources of solitary "cold" nodules in the thyroid. Rarely, the gastrointestinal tract, such as colon, may be the primary site. Extensive involvement of the thyroid by a metastatic colon carcinoma can cause diagnostic difficulties for both the clinician and the pathologist. Differentiation from a primary mucinous carcinoma of the thyroid, in such an instance, would require immunohistochemical stains and electron microscopic study to facilitate correct diagnosis. Such a case of secondary adenocarcinoma of colon bilaterally involving the thyroid, 8 years after removal of the primary, is reported here.