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Tomentodione E, a new sec-pentyl syncarpic acid-based meroterpenoid from the leaves of Rhodomyrtus tomentosa

Abstract A new meroterpenoid, tomentodione E (1), along with four known ones (2–5) were isolated from the leaves of Rhodomyrtus tomentosa. Their structures were elucidated based on extensive spectroscopic data as well as computational methods. Compound 1 represents the first example of meroterpenoid possessing a sec-pentyl syncarpic acid motif coupled with a caryophyllene. Compounds 1–4 were evaluated for their in vitro antiviral activity against respiratory syncytial virus (RSV) with cytopathic effect (CPE) reduction assay, and 2 showed potent in vitro anti-RSV effect.