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Analysis of Amino Acid Substitution Rate in Proteins between Hyperthermophilic and Mesophilic Organisms Using Complete Genome Data

Hyperthermophilic organisms (both bacteria and archaea) grow optimally at temperatures above 80◦C. Proteins from these organisms are heatstable under extreme conditions, where their homologous from mesophilic organisms denature [3]. Because recent progress of genome projects revealed complete nucleotide sequence of many microbial genomes [2], we have compared their amino acid sequences and compositions in proteins between hyperthermophilic (9 species) and mesophilic organisms (26 species).