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Potential Tuberculostatic Agents: Micelle‐Forming Copolymer Poly(ethylene glycol)‐Poly(aspartic acid) Prodrug with Isoniazid

With the objective of obtaining slow‐acting isoniazid derivatives, of potential use as chemoprophylactics or chemotherapeutics in tuberculosis, the micelle‐forming copolymer of poly(ethylene glycol)‐ poly(aspartic acid) prodrug with isoniazid was synthesized. The derivative obtained was found to be active in Mycobacterium tuberculosis culture, with a minimal inhibitory concentration (MIC) 5.6 times lower than that of the tuberculostatic drug.