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5‐Hydroxytryptamine Amplifies β‐Adrenergic Stimulation of N‐Acetyltransferase Activity in Rat Pinealocytes

Abstract: In cultured rat pinealocytes β‐adrenergic induction of N‐acetyltransferase, a key enzyme in the synthesis of melatonin, is amplified by addition of 5‐hydroxytryptamine (5‐HT) to the culture medium. However, 5‐HT when added alone has no effect on enzyme activity. Pharmacological experiments with a range of agonists and antagonists suggest that this action is not mediated by 5‐HT1, 5‐HT2, 5‐HT3, or 5‐HT4 receptor subtypes but may involve a site similar to the 5‐HTip receptor described in the enteric nervous system. The potential role of 5‐HT in modulating adrenergic stimulation of N‐acetyltransferase activity is discussed.