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PROCEEDINGS OF THE DUTCH SOCIETY FOR CLINICAL PHARMACOLOGY AND BIOPHARMACY

either deterministic or stochastic nature. This local dosimetry Selection of radionuclides for radiation in the joint can be calculated with a Monte Carlo model synovectomy with yttrium (Y), erbium [1]. Furthermore, the leakage of radioactive liquid from the (Er) and samarium (Sm): the concept of joint into the rest of the body must be minimal, or at least a therapeutic window after several half-times of decay of the radionuclide. Monte Carlo dosimetry with the EGS4 code was performed for three radionuclides Y, Er and Sm. M. W. KONIJNENBERG, G. J. ENSING & H. H. VAN ROOIJ The results were analysed with dose-effect curves for efficacy Mallinckrodt Medical B.V., P.O. Box 3, 1755 ZG Petten, The Netherlands in the synovial lining and unwanted side-effects in the cartilage and the bone, according to the standard report on deterministic effects from radiation [2]. A therapeutic Radiation synovectomy is a palliative therapy for painful rheumatoid joints. A radioactive liquid with a b-emitting window was defined between the activity that produces an efficacious dose in the synovium and the activity that can radionuclide is directly injected into the joint capsule. Synovectomy agents must be capable of delivering a high possibly damage the cartilage (Table 1). It is recommended that theoretical radiation dosimetry enough radiation dose to the phagocytic layer of the synovium around the joint capsule, which is causing the studies should form an important part of the registration dossier for radio-pharmaceuticals intended for therapeutic pain. The dose to the cartilage, the bone surface and the bone marrow, however, may not exceed any safety level of use.