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A novel multicomponent quadruple/double quadruple domino reaction: highly efficient synthesis of polyheterocyclic architectures.

A novel multicomponent quadruple domino reaction (MCQDR) for the assembly of structurally complex molecular architectures via the formation of three rings and three contiguous stereogenic centers has been accomplished with high regio- and diastereoselectivity. Solvents, catalysts and work-up were not required to obtain the target molecules. In addition, this new protocol is also extended for the multicomponent double quadruple domino reaction (MCDQDR) to create novel polyheterocyclic architectures in an orthogonal manner.