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Cell cycle regulators and apoptosis‐associated proteins in relation to proliferative activity and degree of apoptosis in HNPCC versus sporadic endometrial carcinoma

Aims : Mismatch repair gene malfunction occurs early in the carcinogenesis of hereditary non‐polyposis colorectal cancers (HNPCCs), leading to an accelerated accumulation of mutations and possibly to change in expression of cell cycle proteins. There is strong evidence that tumorigenesis in HNPCCs differs from sporadic ones. HNPCC‐related endometrial cancers are less well studied. Our aim was to compare expression of cell cycle and apoptosis‐related proteins in relation to proliferation and apoptosis in HNPCC‐related and sporadic endometrial cancers to identify differences in their carcinogenetic pathways.