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[Effects of high altitude on the morphofunctional state of mast cells of the subcutaneous connective tissue during physical exercise].

The Wistar male rats were exposed to submaximum exercise (by swimming for 5 hours) at a high altitude (HA) environment (the Tuya-Ashu Pass, 3200 m above sea level). Sampling was done on Days 1, 15, 30 and 45 of animal living in the mountains. The control group of animals was examined in the lowlands regions (Bishkek, 760 m above sea level). It is indicated that during exercises performed in the mountain environments the mast cell reaction judging from the morphologic manifestations is similar to that observed during adaptation without exercises but in this case the cell restoration occurs more rapidly. The study of the time-course of changes in the morphofunctional state of mast cells in both groups of animals allows one to conclude that such an early significant degranulation and mass degradation at early times are conditioned not only by stressful reaction of the body but also by the effects of HA hypoxia and exercise stimulating their subsequent accelerated proliferation due to migration of juvenile forms from the region of cambial reserve to the skin surface compartments.