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Analgesic activity of extracts of Kyllinga monocephala

The analgesic activity of the methanol extract of the leaves of Kyllinga monocephala Rottb. (Cyperaceae) was evaluated using the acetic acid-induced writhing test on mice and was found to significantly reduce the number of writhes in mice by half. Following a bioassay-guided fractionation scheme, statistically significant analgesic activity was observed with both the hexane and ethyl acetate partitions. An active fraction was identified after fractionation of the hexane extract, whereas two active fractions were identified after fractionation of the ethyl acetate extract. This is the first report of the analgesic activity of K. monocephala.