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An antibactericidal factor in the serum of some patients with infections of the upper urinary tract.

1. The serum of two patients with infections of the upper urinary tract contained a specific factor which inhibited its bactericidal action against the Gram-negative organism causing the infection. 2. The serum of the patients was fractionated by gel filtration and anion-exchange chromatography and pooled fractions were examined for antibactericidal activity. 3. Fractions showing antibactericidal activity appeared to contain only immunoglobulin G and it is suggested that bacterium-specific antibactericidal immunoglobulin G competes with immunoglobulin M, the major bactericidal antibody, for sites on the bacterial surface.