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Studies on blood coagulation and fibrinolysis in conditions associated with an increased incidence of thrombosis. Methodological and clinical investigations.

Detailed accounts of methodological and clinical investigations by the author and his associates form the primary substance of the article. The collected accounts comprise a general consideration of blood coagulation and fibrinolysis in conditions associated with an increased risk of thrombosis. One of the clinical experiments described was a comparison between oral contraceptors and untreated women in a longitudinal study of changes in blood coagulation and fibrinolysis. The 3 groups of women studied were 1) studied before and at different intervals during 1 year of oral therapy (15 women) 2) followed with repeated blood sampling before and during 1 or 2 tablet cycles (8) and 3) controls (5). In Group 1 plasminogen concentration was elevated as early as 1 month and remained elevated during treatment. After 5-6 months platelet number was significantly increased. Platelet adhesiveness decreased after 2-3 and 5-6 months. After 5-6 months antifibrinolytic activity increased. The activities of Factors 2 7 and 10 were significantly increased after 2-3 5-6 and 12 months. Fibrinogen and Factor 8 showed no significant changes. In Group 2 clear cyclic variations correlated with tablet use were noted for some parameters. Variations in fibrinogen and plasminogen concentrations and in spontaneous fibrinolytic activity were greater in Group 2 than in Group 3. Choice of oral contraceptive resulted in no notable occurrences. Changes during the puerperium were studied in another experiment. In the course of the article the work of a number of other authors is reviewed.