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CRC Handbook Series in Clinical Laboratory Science. Section D: Blood Banking

The main title 'Hemopoietic Dysplasias' was the consensus term finally agreed by the participants to a conference on 'Preleukaemic States', which is the subtitle. Although the conference was held in 1975 and the proceedings have been published as Volume 2 Nos. 1-2 of Blood Cells, it is nevertheless helpful to have this reedition because the subjezt is one of great theoretical importance. To contemplate the pathology of sideroblastic anaemia, marrow hypoplasia, paroxysmal nocturnal haemoglobinuria, indeed all those conditions which may prezede overt leukaemia, forces us to conceive how the haemopoietic system functions, how successive stages of proliferation and differentiation are controlled, and how break-downs may occur. The speakers deal expertly with the subject from many aspects-clinical, morphological, experimental, theoretical, and so forth-and their discussions are illuminating. If there is one criticism it is the absence of a cytogeneticist since the chromosomal data receive adequate attention only in the section on radiation leukaemogenesis. The distinction between polyclonal and monoclonal proliferations might have been made and the evidence for progression more clearly demonstrated. There are also errors in the editing: on page 349, for example, there is a reference to 'myeloid dysphasia' and it is almost appropriate! But, all in all, for haematologists and oncologists this is a valuable and thought-provoking book.