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Posttranscriptional Regulation of Mu Opioid Receptor (MOR-1): Implications of Alternative Splicing in the Neuropathogenesis of Morphine Tolerance. Literature Review and Research Approach

The National Institute on Drug Addiction has recently rendered drug addiction as ‘a chronic disease characterized by drug seeking and use that is compulsive, or difficult to control despite harmful consequences’ [1]. Physical, biochemical and physiological changes in the brain over time may be accompanied by behavioral and emotional cue of the systematic degradation on brain function with ensuing modifications of the brain reward circuit in chronic users [2-4]. The predictability of man’s responses to morphine intake is highly variable, giving Abstract