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Introduction: Pick's disease and frontotemporal dementia

There is no universally accepted morphological definition of Pick's disease. The concept of frontotemporal dementia (FTD) was proposed by the Lund‐Manchester Group in 1994 and comprises three main subtypes: frontal lobe degeneration type, Pick type and motor neuron disease type. Subsequently, familial or hereditary FTD has been identified, and ‘FTD and parkinsonism linked to chromosome 17’ was defined in 1996. However, there are still unresolved aspects of the neuropathology of FTD. This paper describes the origin and development of the concept of FTD with special reference to the neuropathological problems.