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[Beta adrenergic function of the nasal mucosa in patients with allergic rhinitis].

The purpose of this study was to investigate the jS-adrenergic function on the nasal mucosa of the patients with allergic rhinitis who showed positive skin test, positive provocation test and eosinophilia in their nasal secretion.The cells, which were scraped from the mucous blanket on the nasal mucosa using a small curette, released histamine after the challenge of allergen (×10 house dust), but this release was inhibited 5 minutes after incubation with 10-4 or 10-5M of 1-isoproterenol. The cells from mucous blanket were also incubated in the Tris ACM buffer with or without 10-5M of 1-isoproterenol, and cyclic AMP levels in the cells were measured using radio-immunoassay. The levels of cyclic AMP incubated with 1-isoproterenol were four times higher than those without 1-isoproterenol.Nasal provocation was performed using the disk method. Nasal resistance was measured by the combined rhinomanometry and sneezes, nasal secretion and swelling of the turbinate were observed for 5 minutes after provocation. The increase of nasal airway resistance and allergen-induced nasal symptoms caused by provocation was inhibited after spraying 1-isoproterenol. This responsiveness to 1-isoproterenol as Radrenostimulant suggested that the adenyl cyclase activity and adrenoceptor function of the cells on the nasal mucosa were normal in the patients with nasal allergy.