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An animal model of hypersensitivity pneumonitis in the rabbit. Induction of cellular hypersensitivy to inhaled antigens using carrageenan and BCG.

Previous studies from our laboratory have indicated that long-term aerosol exposure to pigeon dropping extract, one of the etiologic agents of hypersensitivity pneumonitis, did not produce lung lesions (1). However, inflaming the lungs with dead bacillus Calmette-Guerin and continued inhalation of pigeon dropping extract induced cell-mediated hypersensitivity to inhaled antigens in bronchoalveolar cells. On the basis of these data, we suggested that some inflammatory agent that affected the lung could result in the induction of cell-mediated hypersensitivity to inhaled antigens in human hypersensitivity pneumonitis. Data in the present study showed that carrageenan, another inflammatory agent, functions similarly to bacillus Calmette-Guerin in the induction of cell-mediated hypersensitivity to inhaled antigens in bronchoalveolar cells. The successive demonstrations that both bacillus Calmette-Guerin and carrageenan could inflame the lung and permit the induction of cell-mediated hypersensitivity to inhale...