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[Clinical trials of alendronate in Japan].

Alendronate is the first powerful bisphosphonate which will be available in Japan in near future. Its potencies regarding to the inhibition effect of bone resorption and to increase in bone mineral density were remarkable judging from the data in phase II and III clinical trials. Thus, alendronate is expected to have a potency to inhibit bone fracture occurrence in Japanese osteoporotics.