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Inter-individual differences in metabolism of drugs: the role of genetic factors.

: Variability is a frequent finding in pharmacology, and may have a unimodal or polylmodal distribution. Both types of variation are analysable by genetic techniques. Experiments reveal that the variability between persons in their capacity to metabolize drugs is largely genetically determined. Persons who have a greater ability to metabolize a drug may be protected from adverse reactions, but may also not receive therapeutic benefits as compared with those less well endowed, when fixed dosage regimes are utilized.