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Study the function of GTPase related genes wasf1 and ect2 in zebrafish vascular development

Vascular development is important in vertebrates and regulated by complex signaling pathways. In the process of forming vessels are mainly divided into vasculogenesis and angiogenesis. Zebrafish is a powerful vertebrate model organism to study vascular development. Our previous study in zebrafish identified the transcription factors nr2f1b/islet2 required for blood vessels, mainly focus on the patterning of intersegmental vessels (ISV) and caudal vein plexus (CVP). The further microarray results showed that the expression of several GTPase related genes was regulated by nr2f1b/islet2, and we are interested in how those GTPase related genes contribute to vascular patterning in zebrafish.