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Influence of Calcitonin on Bone Phosphatases and Phosphate Release in Organ Culture

Summary Calcitonin promoted an increase in both alkaline and acid phosphatase activities of half-calvaria from 5-day-old mice when the bones were cultured for 48 hr. Calcitonin inhibited the release of phosphorus from bones, relative to the release from control and parathyroid hormone-treated bones, and promoted an uptake of calcium from the culture medium. The results support the concept of a role for calcitonin in phosphate metabolism. This study was supported by Grant No. DE-01850, National Institute for Dental Research, Bethesda, MD.