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Serum protein changes in women with earLY BREAST CANCER

Lowered serum concentrations of albumin, IgG, IgM, and transferrin have been identified preoperatively in a population of otherwise healthy white women over age 40 with early stage breast cancer. Definition of low values for each of the four serum proteins has been arrived at via comparison with age‐matched controls, consisting of disease‐free women and women with benign breast lesions. Thus defined, low values for the individual serum proteins have been found to occur in malignant/control study subjects at the following frequencies: albumin 68%/4.7% (P < 0.0001); IgG 56%/21% (P < 0.02); IgM 59%/19% (P < 0.001), and transferrin 50%/4.7% (P < 0.0001). Among the relevant historical and pathologic data evaluated in addition to the presence or absence of malignancy, only age has been found significant in influencing serum protein concentrations, and this has been taken into account in analyzing results. Forty‐four percent of study sujects subsequently found to have breast cancer have low concentrations of at least three of the four discriminant proteins simultaneously in the pre‐operative sample. None of the controls have these findings. Twenty‐nine percent of women with a malignant breast lesion and 9% of controls have simultaneously low concentrations of two of the four discriminant proteins. Using these measurements of serum proteins it thus becomes possible to assign risk of malignancy when a woman is found to have a breast mass.