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Cardiac Imaging Phenotype in Patients with Coronavirus Disease 2019 - COCARDE study: prospective observational study.

BACKGROUND
The effects of SARS-Cov-2 (COVID-19) on the myocardium and their role in the clinical course of infected patients are still unknown. The severity of SARS-Cov-2 is driven by hyperinflammation and the effects of SARS-Cov-2 on the myocardium may be significant. The present study proposes to use bedside observations and biomarkers to characterize the association COVID-19 with myocardial injury.


OBJECTIVE
The aim of the study is to describe the myocardial function and its evolution over the time in patients infected with SARS-COV-2; and to investigate the link between inflammation and cardiac injury.


METHODS
This prospective, monocentric observational study will enroll 150 patients with suspected or confirmed SARS-COV-2 infection at Toulouse University Hospital, Toulouse, France. Patients admitted in intensive care unit, regular cardiologic ward as well as geriatric ward of our tertiary university hospital will be included during the pandemic period. Blood sampling, electrocardiography, echocardiography, as well as morphometric and demographic data will be prospectively collected.


RESULTS
By October 2020, a total of 86 patients have been included. Estimated final enrolment day is December 31, 2020, with reporting of results at the end of the first quarter of 2021. The first echocardiographic results at admission of 31 patients of the COCARDE-ICU sub-study population show that biological myocardial injury in COVID 19 has low functional impact on left ventricular systolic function.


CONCLUSIONS
A better understanding of the effects of COVID-19 on myocardia function and the links with inflammation would improve patient follow-up and care.


CLINICALTRIAL
Clinicaltrials.gov NCT04358952.


INTERNATIONAL REGISTERED REPORT
DERR1-10.2196/24931.