{'fraction_non_alphanumeric': 0.018094089264173704, 'fraction_numerical': 0.0012062726176115801, 'mean_word_length': 5.384615384615385, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Regulation of the sodium pump during cardiomyocyte adaptation to pregnancy

•  What is the central question of this study? Pregnancy leads to sustained increases in cardiac output and stroke volume. The cellular mechanisms underlying the associated changes in myocardial function are poorly understood. We investigated the role of the sodium pump in the functional adaptations of cardiomyocytes to normal pregnancy. •  What is the main finding and its importance? We found that in normal pregnancy the expression of the α1 Na+–K+‐ATPase isoform is reduced in cardiomyocytes, and there is decreased sodium pump membrane current and elevated steady‐state intracellular sodium. Our findings suggest an important role for reduced expression and activity of the myocardial membrane sodium pump in the cardiac adaptations to pregnancy.