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Correlation between abnormal thyroid function test and thyroid autoimmunity: a systematic review and meta-analysis.

BACKGROUND
This study was to analyze the correlation between abnormal thyroid function detection and thyroid autoimmune disease, so as to provide theoretical guidance for clinical diagnosis of thyroid autoimmune disease.


METHODS
The Chinese databases were searched with a combination of words "thyroid", "thyroid autoimmune disease", "thyroid function testing", "meta-analysis". The entire database was searched in English language databases with the search terms "thyroid", "thyroid autoimmune disease", "thyroid function test ", "meta-analysis". Review manager software was applied for meta-analysis.


RESULTS
A total of 8 articles were finally included. 4 articles reported the T3 level, showing P=0.95, I2=0%, odds ratio (OR) =2.39, 95% confidence interval (CI): 0.79-7.25; 3 articles reported the T4 levels, showing P=0.81, I2=0%, OR =2.16, 95% CI: 0.43-10.71; and 4 articles reported the thyroid stimulating hormone (TSH) level, showing P=0.48, I2=0%, OR =3.20, 95% CI: 1.45-7.07.


DISCUSSION
After a systematic review of the literature, a significant difference was found in T3 and TSH levels between patients with autoimmune thyroid disease and those with a healthy thyroid, but the difference in T4 level was not significant.