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Clinical and morphologic studies on the guinea pig eye infected with human influenza virus strains of different virulence.

Human influenza virus serotypes H3N2 and H2N2 caused iridocyclitis and uveitis when inoculated at does of 10(6) 6.5 EID50 into the guinea pig eye anterior chamber. Virulent influenza virus strains and their attenuated variants prepared by passaging in chick embryos (CE) have been compared in this model. These studies showed that virulent viruses cause more severe damage in the eyes than the attenuated strains.