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Skeletal muscle secreted myonectin maintains systemic metabolic homeostasis

Skeletal muscle is the largest organ in lean individuals with high secretory capacity, regulating systemic metabolism by exerting endocrine, paracrine and autocrine effects. Myonectin, also designated as family with sequence similarity 132B (FAM132B), is a novel cytokine predominantly secreted by skeletal muscle. Despite its role as a potent regulator of lipid uptake in cultured cells, the physiological function of myonectin in maintaining systemic metabolic homeostasis remains to be fully elucidated.