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The response to isoproterenol in normal subjects and subjects with asthma.

In an attempt to find some simple means of distinguishing asthmatic subjects with normal function from normal subjects, the response to isoproterenol of 60 asthmatic subjects and 28 normal subjects was compared. The per cent improvement in airway conductance was similar in the 2 groups. Although the changes in specific conductance differed significantly between the 2 groups, the increase in normal subjects was too large to be useful in differentiating individual asthmatic patients from normal persons. As expected, expiratory flows did not distinguish asthmatic subjects with normal function from normal subjects.