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EPIGENETIC MECHANISMS AND PARANEOPLASTIC PHENOMENA *

The study of the biology and biochemistry of neoplastic systems over the past few years has indicated that epigenetic mechanisms may operate in the initiation and progression of neoplasms. The possibility that epigenetic mechanisms may also operate in paraneoplastic syndromes has been suggested' on the basis of a large number of clinical observations. In this paper, I shall first discuss some molecular and physical bases of the operation of epigenetic mechanisms in cellular differentiation and then interpret, in epigenetic terms, some specific interactions that occur between neoplastic and embryonic cells in experimental systems. Finally, I shall attempt to show how these investigations might reveal the operation of epigenetic mechanisms in producing paraneoplastic syndromes and allow the formulation of an epigenetic model that might aid in the understanding of these syndromes.