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Validity of MRI brain perfusion imaging method

Brain perfusion imaging using Dynamic Susceptibility Contrast Magnetic Resonance Imaging is very promising method since it can be easily implemented as a standard contrast-based MRI procedure. Quantitative brain perfusion description by DSC-MRI data post processing requires validation. Different validation analysis was performed to verify the influence of a bolus dispersion, delay, low SNR and calculation procedures on final perfusion parameter values. The results indicate that quantitative description of brain perfusion using DSC-MRI is possible and can be acceptable with accuracy about 10%.