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Interventions for vitiligo: a summarised Cochrane review

In this update, 57 trials (including 19 from the original review) with 3139 participants were assessed. Most of the RCTs, which covered a wide range of interventions, had < 50 participants. All of the studies assessed repigmentation, six measured cessation of spread, and five investigated the effect of treatment on quality of life. Most of the studies assessed combination therapies which generally reported better results. New interventions include monochromatic excimer light, Polypodium leucotomos, melanocyte transplantation, oral antioxidants, Chinese zengse pill, and pimecrolimus. We analysed the data from 28 studies that met our outcome criteria of improvement in quality of life and > 75% repigmentation. Fifteen analyses from studies comparing various interventions showed a statistically significant difference between the proportions of participants achieving more than 75% repigmentation. The majority of analyses showing statistically significant differences were from studies that assessed combination interventions, which generally included some form of light treatment. Studies on topical preparations, in particular corticosteroids, reported the largest number of adverse effects. However, in the combination studies it was difficult to ascertain which treatment caused these effects. None of the studies was able to demonstrate long-term benefits. Very few studies were conducted on children or included segmental vitiligo. We found one study of psychological interventions and none evaluating CP D