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A SIMPLE AND VALIDATED RP-HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF TINIDAZOLE AND CIPROFLOXACIN IN BULK AND PHARMACEUTICAL DOSAGE FORMS

A simple, rapid, specific, accurate and precise reverse phase high performance liquid chromatographic method was developed for the simultaneous estimation of Tinidazole and Ciprofloxacin in Tabletdosage form. An Aligant Zorbax Rx-C18 5µ column having 150 x 4.6mm id in Isocratic mode with mobile phase containing Orthophosphoric acid: methanol (70:30 %v/v pH: 3.0) was used. The flow rate was 1.5ml/min and effluents were monitored at 225nm.) The retention time of Tinidazole and Ciprofloxacin was 2.3min and 7.2min respectively.The concentration curves of Tinidazole and Ciprofloxacin were linear in the concentration range of 150-450 µg/mL and 125-375µg/mL respectively. The developed method was validated for specificity, precision, linearity, accuracy, LOD,LOQ, robustness . Recovery of Tinidazole and Ciprofloxacin in formulations was found to be in the range of 97.0% -98.0% and 100%-103% respectively confirms the non-interferences of the excipients in the formulation. Due to its simplicity, rapidness and high precision, the proposed HPLC method may be used for the simultaneous determination of these two drugs in pharmaceutical dosage forms.