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Measles, mumps, and rubella vaccine was not associated with autism in children

Main results The 537 303 children had follow up for a total of 2 129 864 person years. 440 655 children (82%) received the MMR vaccine; mean age at time of vaccination was 17 months. 316 children had autistic disorder (mean age at diagnosis 4 y, 3 mo), and 422 children had other autistic spectrum disorders (mean age 5 y, 3 mo). Analysis adjusted for age, calendar period, sex, birth weight, gestational age, mother’s education, and socioeconomic status showed that children who received the MMR vaccine did not have an increased risk of autistic disorder or other autistic spectrum disorders compared with children who did not receive the vaccine (table). Risk of autistic disorder was not associated with age at time of vaccination (p=0.23), time interval since vaccination (p=0.42), or calendar period at time of vaccination (p=0.06).