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High levels of serotonin modulate oxidative balance in brain's area related with anxiety behavior?

There is abundant evidence that manipulating of serotonin system can affect innumerous behavior. Anxiety behavior's test had shown contradicted reports, some studies had shown that higher levels of serotonin increase anxiety and other shows no significant effect. In addiction, studies are showing that some behaviors alteration are linked to the reactive oxygen specie production which may induce oxidative stress. With this our aim was evaluate the effect manipulation of serotonin system during the lactation time on anxiety behavior and oxidative balance in hippocampus. The treatment was carryout during the lactation time using 10mg/Kg B.W. (i.p injection) in female Wistar rats. In vivo was evaluated anxiety behavior using elevated plus‐maze (EPM) test and in vitro we evaluate the levels of oxidative stress (Malondialdeyde‐MDA), antioxidant enzyme (superoxide dismutase‐SOD, catalase activity‐CAT and glutathione S‐transferase‐GST)on hippocampus. Our data suggest that modulation of serotonin levels by fluoxetine during developmental period decrease levels of oxidative stress accompanied by a reduction in anxiety levels. The present study receives financial support from FACEPE and CNPq.