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[Study on the expression of matrix metalloproteinase-12 and NM_002426 in squamous laryngeal carcinoma].

OBJECTIVE
Matrix metalloproteinases (MMPs) are key factors which influence the grades and/or metastasis of stereo tumour. There are short of research of MMP-12 now. The experiment is done to investigate the expression of MMP-12 and NM_002426, and relationship between the two genes and the biologic behavior in squamous laryngeal carcinoma.


METHOD
Thirty pairs of specimens, include supraglottic carcinoma tissue and normal mucosa, were chosen. Three gene arrays, based on different kinds of malignant, were made to study NM_ 002426 at first, then immunohistochemical method were used to observe the difference of MMP-12 between tumour and normal mucosa, metastasis group and no-metastasis group.


RESULT
NM_002426 express high ratio in all 3 chips, and have the highest mark in both mid-level and high-level malignant tissue. The immunohistochemical results showed that MMP-12 had significant difference between tumour and normal mucosa, metastasis group and no-metastasis group. The MMP-12 expression was unrelated to different malignant degree.


CONCLUSION
NM_ 002426 has significant hyperplasia in squamous laryngeal carcinoma, which caused high expression of MMP-12,and it makes a main contribution to the carcinogenesis and metastasis of laryngeal carcinoma. MMP-12 and its gene overexpress may be a auxiliary diagnosis method.