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The Nature of Drug‐Induced B Cell Tolerance

The unifying concept of tolerance which was once widely accepted has given way to a realisation that specific unresponsiveness can be due to several distinct cellular events and that T and B lymphocytes are affected independently and differently. Whilst the relative contributions of suppressor T cells and clonal deletion to T cell tolerance phenomena are still being evaluated, a state of ignorance surrounds the latter mechanism. Whatever its nature, it is exceedingly difficult to induce in vitro, does not depend on multivalency, and is not inducible with potent B cell tolerogens. In contrast, the events involved in B cell tolerance are now being rapidly clarified, although the induction pathways involved with TD and TI antigens are dissimilar. TD antigens, provided they possess a moderate degree of multivalency, can tolerize immature B cells in perinatal animals the phenomenon of "Cional abortion*. Upon maturation, B cells generally resist tolerization by