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[Level of immunoreactive adrenocorticotropic hormone in the pituitary gland and blood of humans during prenatal development].

The levels of immunoreactive ACTH were determined in 109 pituitaries and in serum of human fetuses from the 7th to the 34th week of intrauterine life, and in serum of 7 infants. ACTH in the pituitary is detectable for the first time in a 7-week-old embryo. The mean content and concentration of ACTH in the pituitary significantly increases twice: between weeks 7-13 and between weeks 17-34, with a peak at the 34th week. Immunoreactive ACTH is detectable in serum from the 12th week of gestation. A significant rise was recorded at the 24th week, with maximum being reached by the 34th week. Serum ACTH decreases more than 10-fold by the time of the term as compared with that by the 34th week. The data obtained suggest that the pituitary of man starts ACTH synthesis from the 7th week and secrets it into fetal blood from the 12th week of prenatal development.