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Levodopa in borderline disorders.

To the Editor. —Many people believe that treatment of the borderline personality disorder is neither cost-effective nor clinically effective. In fact, this disorder usually seems to be refractory to a wide range of drugs, and the patients seem to experience most of the side effects and few of the benefits of the commonly used agents. 1 We have dealt with the substance-abusing population in the New York metropolitan area and, true to DSM-III criteria, encountered within it a high proportion of patients with borderline personality. Observations of how the conditions of patients with borderline disorder respond to neuroleptic and antidepressant agents, and observations as to abuse substances of choice (along with the patients' reasons for preferring a particular drug) suggest that these patients are self-medicators. 1 These factors and our clinical observations led us to suspect that many patients with borderline syndrome, especially those who exhibit symptoms of marked boredom, dysphoria,