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A Review: Current Status and Emerging Developments on Natural Polymer-Based Electrospun Fibers.

In recent years, natural polymer-based electrospun fibers (EFs) with huge specific surface area, good biocompatibility and biological activity obtained from electrospinning process exhibit tremendous vitality in the field of biomedical areas. Herein, the parameters of electrospinning from two perspectives, polymer solution such as solvent, polymeric relative molecular mass, concentration, viscosity and conductivity of the solution and electrospinning process such as spinning voltage, spinning flow rate, needle tip to collector distance, temperature and humidity was firstly detailed. Next, the raw materials consisting of polysaccharides such as cellulose, hyaluronic acid, alginate and chitosan as well as proteins such as collagen, gelatin, silk fibroin and keratin were summarized. The preparation method and related characteristics of EFs with multistage structures such as porous, core-shell, Janus, bamboo-like and other structures were introduced. The biomedical applications of these natural polymer-based EFs mainly including tissue engineering, drug sustained release, wound dressings, and biomedical sensors were systematically recapitulated. Finally, the outlook about natural EFs was further proposed. This article is protected by copyright. All rights reserved.