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Secretin Regulates the Expression of the Renin‐Angiotensin System in Rat Cardiac Fibroblasts

Secretin (SCT) is a peptide hormone produced mainly by the S cells of the duodenum that exerts its biological effects through the G‐protein coupled secretin receptor (SCTR). Studies have indicated that SCT stimulates cardiac adenylyl cyclase activity and exerts a positive inotropic action in the heart. The expression of SCT/SCTR or the effect of SCT on cardiac fibroblasts has not been fully explored. The AIM of our study was to determine the expression of SCT and SCTR in cardiac fibroblasts and to explore the effect of SCT on cardiac fibroblast expression of the renin‐angiotensin system (RAS).