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Patients with ‘interval’ colorectal cancers have worse outcomes compared with cancers in patients who decline the National Bowel Cancer Screening Programme – Results from a Multicentre Study

We write to highlight a unique and inadvertent study finding, that patients on the national guaiac-based faecal occult blood testing (FOBT) screening programme, who developed interval colorectal cancers (IC) and in particular right-sided cancers, had a worse outcome compared with cancers in patients who declined to participate in the National FOBT screening process. This was identified as part of a UK-based multicentre study looking into FOBT and interval cancers in patients on incident rounds of screening(1). 
 
In the United Kingdom, colorectal cancer (CRC) is the second most common form of cancer-related mortality, with less than half surviving for more than 5 years. Biennial FOBT screening has reduced CRC mortality, mainly though the early detection and improved survival of screen detected cancers (2). 
 
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