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The innate immune response in calves to Boophilus microplus tick transmitted Babesia bovis involves type‐1 cytokine induction and NK‐like cells in the spleen

The innate immune response to Babesia bovis infection in cattle is age‐related, spleen‐dependent and, in stabilate inoculated calves, has type‐1 characteristics, including the early induction of IL‐12 and IFN‐γ. In this study with three calves, parameters of innate immunity were followed for 2 weeks after tick transmission of B. bovis. Each calf survived the acute disease episode without drug intervention, and responded with increased levels of plasma interferon‐γ and type‐1 cytokine expression, monocyte/macrophage activation, and CD8+cellular proliferation in the spleen. The proliferating CD8+population consisted primarily of NK‐like cells, and the expansion occurred in parallel with an increase in IL‐15 mRNA expression in the spleen.