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Clonal expansion of human B73.1-positive natural killer cells or large granular lymphocytes exerting strong antibody-dependent and -independent cytotoxicity and occasionally lectin-dependent cytotoxicity.

B73.1-positive natural killer (NK) cells were separated from B73.1- cells by fluorescent-activated cell sorting and used for the generation of cytotoxic clones. The B73.1+ and B73.1- cells were cultured at one responder cell per well in medium with feeder cells and interleukin 2 but without lectins. The plating efficiency of B73.1- cells (about 4%) but not of B73.1+ cells was increased 3- to 7-fold by addition of lectin. All B73.1+ clones showed a high cytolytic activity against a wide variety of human NK-susceptible target cells, such as K562, MOLT-4 and HSB, but not against murine cell lines (P815). They also lysed several NK-insensitive Epstein-Barr virus-transformed B cell lines (B-LCLs), Daudi cells, the bladder tumor cell line T24 and melanoma tumor cells. B73.1+ clones also exerted antibody-dependent cellular cytotoxicity. Only 1 of 20 clones derived from the B73.1- fraction showed a similar pattern of cytolytic activity. In addition, some clones derived from both B73.1+ and B73.1- fractions were able to exert lectin-dependent cellular cytotoxicity.