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Treatment of chronic dermatophyte infections. The use of ketoconazole in griseofulvin treatment failures

Twenty‐eight patients with chronic dermatophytosis who had failed to respond to griseofulvin were treated with ketoconazole for periods of up to 18 months. Seventy‐two per cent of patients with unresponsive infections on the trunk, proximal limb or groins responded to therapy without early relapse in under 6 months. By contrast 82%, of patients with sole or toe nail infections either failed to respond to therapy or relapsed within 6 months of stopping the drug. There was no evidence that the initial minimum inhibitory concentration of the organism influenced the outcome or that drug resistance developed during treatment.