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Accelerated DOT reconstruction using multiple sub-volumes

We present a new method to reconstruct arbitrary large volumes in (fluorescence) diffuse optical tomography by splitting the volume of reconstruction into sub-volumes. This allows to perform nonlinear reconstruction on large grids with a larger number of measurement data and more grid nodes than conventional reconstruction schemes, where images are reconstructed on a single grid. We investigate how the reconstructed spatial distributions of diffusion and absorption coefficients using the new method depend on the size of the sub-volumes, compare the convergence to the conventional nonlinear approach, and present an error estimation.