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CLINICAL TRIAL EVIDENCE ON CURCUMIN POTENTIAL FOR TYPE 2 DIABETES MELLITUS TREATMENT: A SYSTEMATIC REVIEW FROM 2015-2020

Regardless of the availability of diabetes medicines, diabetes mellitus and its complications are increasing and still a major global problem. This study aims to review the potential of curcumin to prevent diabetes mellitus complications in humans. A literature search with a systematic method was carried out across four databases (PubMed, Cochrane, ScienceDirect, and Taylor and Francis) from 2015-2020. Triglyceride (TG), Low-Density Lipoprotein-cholesterol (LDL-c), Body Mass Index (BMI), and body weight are the top four outcome parameters that have significant changes compared with the baseline condition. Meanwhile, when comparing the results with the control group, only TG, BMI, and body weight were observed to be significantly improved. Curcumin supplements administered through oral route, with their medicinal properties such as anti-inflammatory and antioxidant, have a significant role in preventing the development of cardiovascular, neurological, and nephrological complications in the diabetic patient through improving lipid profile, vascular stiffness, inflammation, and oxidative stress.