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DISSEMINATED FUSARIUM IN THE IMMUNOCOMPROMISED HOST

Aggressive immunosuppressive therapy and treatment with broad-spectrum antibiotics have led to the emergence of severe infections with previously described “non-pathogenic” moulds. We report on a series of patients with disseminated and recurrent fusarium infections at our institution. High-dose amphotericin B or amphotericin B lipid complex with or without surgical debridement and return of the absolute neutrophil count to above 1000 cells/mm3 is the key to resolution of infection and survival. More effective regimens and aggressive supportive therapy will determine improved outcomes in the future.