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Basic Concepts in the Use of Amino Acids and Protein Hydrolysates for Parenteral Nutrition

THE PROVISION OF AMINO ACIDS FOR parenteral feeding of human patients can call on a century of study of the protein requirements of man. Even so, a convincing statement of the needs of man for protein and for individual essential amino acids has yet to emerge. The purposes of this present review article are threefold. First, it is intended to provide a digest of current information and opinion about the requirements of healthy subjects for total protein and for individual essential amino acids in the diet. Second, it will deal with the adaptation of these requirements to intravenous nutrition, emphasizing differences in metabolism that might be anticipated as a result of bypassing the alimentary tract and liver. Third, some amino acid mixtures and protein hydrolysates currently used for parenteral administration will be examined in the light of these conclusions and changes in amino acid requirements resulting from disease will be discussed.