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A Comparative study between the effect of oxytocin and human chorionic gonadotropin on induction of ovulation

Background: Ovulation induction as well as endometrial maturation acceleration are significant aspects of assisted reproductive technology (ART). Superovulation with synthetic medicines may cause hyperstimulation syndrome, atretic follicle formation, and endometrial maturity impairment. As a result, a drug that does not have such negative impacts would be preferable. Aim of the work: To compare the effects of oxytocin and human chorionic gonadotrophin. Patients and methods: A total of 100 patients with anovulation were enrolled in this randomized prospective interventional study. The data was collected from the patients assigned according to exclusion and inclusion criteria at Al-Hussein Al-Azhar University Hospital and Dar Ismael Hospital in from May 2019 to May 2021. Results: According to occurrence of ovulation in Group A 38 (76%) subjects ovulated, while 12 (24%) subjects didn't ovulate. According to occurrence of ovulation in Group B 32 (64%) subjects ovulated, while 18 (36%) subjects didn't ovulate. In terms of plasma progesterone levels, there has been a significant difference between the study groups. There was no difference between studied groups as regard AMH levels. According to Pregnancy in Group A there were 14 (28%) pregnant and 36 (72%) not Pregnant. In Group B there were 34 (68%) not Pregnant and 16 (32%) pregnant. In terms of pregnancy, there has been no statistically significant difference between the study groups. Conclusion: Oxytocin plus clomiphene citrate is as efficient as human chorionic gonadotropin (HCG) with clomiphene citrate in inducing ovulation triggering and can be recommended as a replacement for HCG.