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Hyperadrenocorticism in association with an adrenocortical adenoma in a pet ferret.

Spontaneous hyperadrenocorticism (Cushing's syndrome) is a disorder caused by the excessive production of cortisol by the adrenal cortex (1-4). This disease is uncommon in the dog and human and is extremely rare in cats (5). Recently the first three cases of naturally occurring hyperadrenocorticism in hamsters were reported (6). However, only one case, which was confirmed at necropsy, has been reported in a ferret (7). A four and one-half-year-old spayed female ferret was presented to the veterinary hospital of the University of Montreal with a primary complaint of nonpruritic alopecia. On physical examination, the ferret was in good health, alert and weighed 650 g. The body temperature, heart rate, and respiration were normal. An alopecic area 2 cm in diameter on the dorsal aspect of the neck had been present for eight months (Figure 1), and a 1.5 x 2.5 cm area of alopecia on the lumbosacral area and base of the tail had been present for only two weeks (Figure 2). The skin