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Protective effects of Qishenghuoxue Granule in sepsis rats

Objective To observe the changes of heart function, myocardial mechanics in sepsis rat model and to investigate mechanism of the protective effect of Qishenghuoxue Granule on heart. Methods Wistar rats were randomly divided into control group, LPS group (4 mg/kg LPS i.v.), LPS+Qishenghuoxue Granule group (4mg/kg LPS+8.4 g/kg Qishenghuoxue Granule po), thirty-two rats for each group. Rats were intubated through right common carotid artery to left cardiac ventricle. Function of the left ventricle was monitored and blood was drawn at the 0, 2nd, 4th, 6th hour to detect concentrations of TNF-α, Ang-Ⅱand TNT, eight rats for each time point. Results In sepsis rats, TNT increased significantly and could be relieved by Qishenghuoxue Granule[(1.30±0.53)μg/L vs (0.68±0.82) μg/L, P 0.05]. LVPP and ±dp/dt changed in different degree, LVEDP increased, but these changes could be compromised when using Qishenghuoxue Granule. TNF-α and Ang-Ⅱ increased significantly in sepsis rats, but Qishenghuoxue Granule could decrease its concentration, [(10.16±1.74)pmol/L vs (7.60±1.79) pmol/L P 0.05] and [(1089.96±365.4) ng/L vs (625.30±224.71) ng/L P 0.01]. Conclusions Myocardium was obviously damaged in rats with sepsis. Qishenghuoxue Granule could relieve cardiac damage caused by endotoxin in sepsis model.