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[Implementation of the interferon-γ release assay for contact tracing: a 2-year project in lower Saxony, Germany].

At the beginning of 2007 the Governmental Institute of Public Health of Lower Saxony, Germany (NLGA), initialised a project for the public health service (OGD) of Lower Saxony to establish the serological tuberculin test (interferon-γ release assay, IGRA) for contact tracing. So far contact tracing was done inconsistently in Lower Saxony. Up to now the main diagnostic method for detecting a latent tuberculosis was the radiographic test as well as the tuberculin skin test. But both methods are not suitable for detecting a latent tuberculosis because of their low sensitivity and specificity. At the beginning of the project the OGD was recommended to use a two-stage procedure. First, the tuberculin skin test should be made and in case of a positive reaction testing with IGRA should follow. After 2 years 37 (80.4%) of the 46 administrative districts have established the IGRA for tuberculosis contact tracing. A positive result of the tuberculin skin test could not be certified by IGRA for about 558 (65.4%) of the tested persons. This means that 2/3 of close contact persons with a positive skin test could be excluded from contact tracing and for them no further examination was necessary. Because of this result of the project, the IGRA now is a freeof-charge analysis at the NLGA for the OGD.