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Chemical study and anti‐inflammatory, analgesic and antioxidant activities of the leaves of Aristotelia chilensis (Mol.) Stuntz, Elaeocarpaceae

Objectives  Aristotelia chilensis leaves (Elaeocarpaceae) are used in Chilean folk medicine to treat pain and inflammation. A bioguided study was carried out on serial extracts (hexane, dichloromethane, methanol, aqueous extract (INFU) and a crude mixture of alkaloids (ALK‐MIX). All extracts were evaluated for (1) topical administration against both arachidonic acid and 12‐deoxyphorbol‐13‐decanoate (TPA)‐induced inflammation in mice and (2) per‐os administration against inflammation by λ‐carrageenan‐induced paw oedema in guinea‐pigs and (3) topical analgesia in tail flick and formalin models and per‐os writhing test in mice.