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HLA‐DR Matching and Immune Regulation

We read with interest the article by Rodriguez et al. in which an association between delayed-type-hypersensitivity (DTH)-regulation and HLA-DR matching was found (1). Our unpublished data, presented at ICTS 2002, looking at regulation by human CD4+CD25+ cells in vitro was consistent with their findings, but with an important caveat (Game and Lechler, abstract O239). We have hypothesised that CD4+CD25+ cells are self-HLA restricted and specific for a variety of self-antigens, although cross-reactivity with alloantigens will also occur (2). If this is the case then suppression of alloresponses is likely to be strongest in cases of HLA-DR matching.