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INFLUENCE OF CURCUMA LONGA AND CURCUMIN ON BLOOD PROFILE IN MICE SUBJECTED TO AFLATOXIN B1

In the present study, toxicity was developed by oral administration of AFB1 at a dose of (2μg/kg body weight) for 45 days in male mice. Curcuma longa (100 and 200 mg/kg body weight) and Curcumin (50 and 100 mg/kg body weight) were given individually and in combination with AFB1 for 45 days. At the end of 45 days, the blood samples were collected from various groups by heart puncture in eppendroff tubes with anticoagulant for hematological assays. Noncoagulated blood was tested for total erythrocyte count, total leukocyte count, hemoglobin, differential leukocyte count and for other blood indices. The results of present study suggest that Turmeric rhizome powder (Curcuma longa) and Curcumin showed protective effects against AFB1 induced toxicity by modulating red blood cell count, white blood cell count and Hb percentage to some extent.