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Eradication rate of Helicobacter Pylori infection is directly influenced by adherence to therapy in children

Current commonly accepted strategies to eradicate Helicobacter pylori in children are a 10‐day sequential treatment or a triple therapy for 7‐14 days. To avoid further expensive and possibly risky investigations as well as induction of secondary antimicrobial resistance, a success rate of elimination strategies over 90% in a per‐protocol analysis is the target goal but rates observed in clinical trials are lower. Antimicrobial resistance is a well‐recognized risk factor for treatment failure; therefore, only a treatment tailored to susceptibility testing should be recommended. Adherence to therapy is also a risk factor for treatment failure but that has been poorly studied. The purpose of this study was to evaluate the influence of adherence to therapy on the elimination rates obtained with different treatment regimens.