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Treatment Of Mania: Relationship Between Response to Verapamil and Changes in Plasma Calcium and Magnesium Levels

Twelve patients meeting DSM-IIIR criteria for mania received verapamil over a 2-week period, with dosing up to 360 mg/day. Severity of mania was measured at baseline and weekly by use of the Young Mania Scale. Plasma calcium and magnesium determinations and an ECG were obtained at baseline and after 2 weeks of treatment. Mean improvement was from a baseline of 32.4 to 12.8, -60.5%. Decreased severity of mania correlated significantly with increased plasma calcium. This result may lend a method for monitoring successful treatment of mania with calcium channel inhibitors.