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[High performance liquid chromatographic determination of flunarizine in biological materials].

A high performance liquid chromatographic procedure has been developed for the determination of flunarizine in biological materials . Flunarizine and the internal standard (cinnarizine) were extracted from alkalinized biological fluids with n-heptane and analyzed by using a reversed phase column and fluorescence detection of flunarizine . The detection limits were 1 ng/ml of the plasma (serum) and 10 ng/g of the brain and extraction recoveries were sufficiently high (89.5-100.2%). The method was applied to plasma samples from dogs after intravenous or oral administration (0.847 mg/kg, flunarizine•22HCl 1 mg/kg), and is possible to be applied to human serum samples and rat brain samples.