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Correlation between digital clubbing and pulmonary function in cystic fibrosis

The correlation between digital clubbing and certain pulmonary function derangements (hypoxemia and FEV1) was previously described. However, the relationship between digital clubbing and other measures of pulmonary function or the presence of liver disease in patients with cystic fibrosis (CF) is poorly defined. Hence we compared the digital clubbing index (CI: ratio of distal phalangeal depth to interphalangeal depth) of 100 patients with CF (43 males, 57 females; mean age, 15.7 ± 7.3 years) with that of 100 age‐ and gender‐matched healthy controls. Digital clubbing was defined as a CI ≥ 1.00 (mean + 2.6 SD; 99% of normal subjects). The CI and its relationship to pulmonary function and to liver disease was then evaluated in the CF patients.