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Internal jugular vein sampling in adrenocorticotropic hormone‐dependent Cushing's syndrome: a comparison with inferior petrosal sinus sampling

objective  Distinguishing between pituitary‐dependent Cushing's syndrome (CS) and occult ectopic ACTH syndrome can be extremely difficult. Bilateral inferior petrosal sinus sampling has been shown to have the highest diagnostic accuracy in this subtype evaluation. Internal jugular vein sampling (IJVS) has been reported as a potentially safer invasive alternative, but data are limited. Our objective was to compare the sensitivity and specificity of bilateral IJVS and bilateral inferior petrosal sinus sampling (IPSS) in patients with ACTH‐dependent CS.