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Molecular Neurobiological Researches on Epilepsy

The special neuroscientific session of the 27th Annual Meeting of the Japan Epilepsy Society, “Molecular Neurobiological Researches on Epilepsy,” was held in Hirosaki on October 2, 1993. The past special sessions “Biological Study on Pathophysiology of Epilepsy” had been organized by Professors Mitsumoto Sat0 and Toshio Yamauchi at the 22nd-26th Annual Meeting.’ This session was planned by the “Commission of the LongTerm Planning for the Control of Epilepsy” of the Japan Epilepsy Society (Chairman: Professor Nariyoshi Yamaguchi), to encourage a new neurobiological approach to understand the basic mechanisms of epilepsy. The three major topics of molecular neurobiological research included: 1) Clinical and molecular genetics in epilepsy; 2) Seizure activity induced gene expression; and 3) Molecular study of neurotransmitter, receptor and other brain substances. The first speaker, Dr. Sugimoto, reported neurophysiological and neurobiological findings in 3 siblings with Angelman syndrome. He showed that epileptic foci resided in the temporal cortex in these cases, using the dipole tracing method. He indicated that Angelman syndrome was a good model of