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Synthesis of Thienyl-Isoxazolines and in vitro Screening for their Antimicrobial Activity

A series of thiophene conjugated isoxazoles were efficiently synthesized using a recyclable heterogeneous
catalyst Amberlyst-15 in good yields. The synthesized new compounds 5(a-j) were characterized by
spectral and elemental analysis and screened in vitro for their antimicrobial potencies. Amongst the
synthesized series; compounds 5c and 5j having chloro substitution on both thiophene and aromatic
ring exhibited excellent inhibition against the tested species