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Second Primary Tumor: P53 and Ki-67 Expression in Patients with Oral Squamous Cell Carcinoma

Recent technical and scientific advances on oncology allowed increase of patients’ survival, sequelae reduction and prevention of other tumours, including second primary tumours (SPT). Indeed, some individuals with head and neck cancer manage to survive the first primary tumour, but cannot resist the second. For these reasons, studies to evaluate the factors related to SPT development of are greatly heightened. The aim of this study was correlate the immunoexpression of ki-67 and p53 proteins in oral squamous cell carcinoma (SCC) in two groups: Group A patients who suffered from a primary tumour of the mouth, and Group B patients who developed a SPT. All subjects studied had histological diagnoses of SCC and were admitted to the Erasto Gaertner Hospital, Brazil, from 1990 to 2005 – 35 at Group A and 20 at Group B. All patients’ medical records were reviewed, and immunohistochemistry reactions were realized for ki-67 and p53 proteins. Analysis was made using the chi-square test and the Student's t-test. There was no statistically significant difference (p=0.8768) of p53 expression between groups. In contrast, ki-67 expression showed a statistically significant difference (p=0.0519), with Group B presenting higher staining, showing that positivity was associated with an increased risk of SPT development.