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THREE-DIMENSIONAL MEAN COMPUTED TOMOGRAPHY VALUE OF PURE OR PART-SOLID GROUND-GLASS NODULE CAN PREDICT TUMOUR INVASIVENESS OF SMALL LUNG ADENOCARCINOMA

mandate discontinuation of the treatment were observed in 14 (28%) patients in the PG-B12 and 2 (4%) patients in the DP group. Conclusions: Pregabalin and methylcobalamin combination is safe and effec- tive in the treatment of CPTP with minimal side effects and a high patient com-pliance. These results should be supported by multidisciplinary studies with larger sample sizes and longer follow-ups. Computed tomography (CT) value of ground glass nodule (GGN) on high-resolution CT images has been reported to be one of the prognostic factors in lung adenocarcinoma. However, in previous reports, radiological evalua- tions have demonstrated only by two-dimensional CT images. CT value of GGN detected with 3-dimensional CT might reﬂect the tumour invasiveness more precisely because quantitative evaluation will be possible for every axis. Thus, we aimed to investigate the relationship between 3-dimensional CT value of GGN and tumour invasiveness in lung adenocarcinoma. Methods: A retrospective study was conducted on surgically treated 96 nodules in 95 patients with pure or part-solid GGNs (cid:2) 2 cm. CT value with 3-dimensional CTwas detected using an automated volumetric software (Synapse Vincent V R , Fuji Film Co., Tokyo, Japan). Clinical characteristics, maximum diameter, mean CT value with conventional two-dimensional CT, mean CT value with 3- dimensional CT, SUV value with FDG-PETwere evaluated. The invasiveness of adenocarcinoma was diagnosed according to the International Association for the Study of Lung Cancer (IASLC)/American Thoracic surgery (ATS)/European Respiratory Society (ERS) classiﬁcation. Preinvasive lesions and minimally- invasive adenocarcinoma were categorized into non-invasive adenocarcinoma. Results: There were 66 non-invasive adenocarcinomas and 30 invasive adeno- carcinomas. Univariate analysis demonstrated 4 predictors of tumour invasiveness: maximum diameter, mean CT value with two- and 3-dimensional CT, SUV value ( P <0.05, respectively). The area under the receiver operating charac-teristic curve to predict invasive adenocarcinoma for 3-dimensional mean CT value was higher than the one for two-dimensional mean CT value (0.831, 0.803, respectively). For differentiation between non-invasive and invasive adenocarcinoma, the 3-dimensional mean CT value was -489 Hounsﬁeld units was optimal. Conclusions: Mean CT values with both 2- and 3-dimensional CT were inde-pendent predictors of pathological invasiveness in pure or part-solid GGN. Three-dimensional mean CT value was more strongly correlated with tumour invasiveness than 2-dimensional mean CT value. Disclosure: No signiﬁcant relationships. Objectives: Preoperative pulmonary rehabilitation (PR) has been shown as an effective strategy to reduce the incidence of postoperative complications (PPCs) as well as the postoperative hospital length of stay in patients under- going resection, via a 2-4 week duration. However, the feasibility and practic-ability of the PR programme published are remains quite controversial. Methods: A 3-armed randomized controlled trial with a total of 90 surgical lung cancer (LC) patients with risk factors was conducted. Grouping with a 1:1:1 ratio and all treated with a one-week time preoperative intervention. Intervention patterns were performed with preoperative in-patient high-inten- sive PR (Combined with inspiratory muscle training (IMT) and aerobic endurance training), conventional PR (Single IMT) and routine preoperative preparation (Control) respectively. Primary endpoints were PPCs occurred in 30 days and length of hospital stay, secondary endpoints included the