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Electrochemically controlled deconjugation and delivery of single quantum dots into the nucleus of living cells.

It is becoming increasingly clear that the nuclear architecture plays an essential role in the genome maintenance and functions.[1] However, the study of nuclear structures, dynamics, and functions presents a major challenge to biological scientists. The key challenge is the imaging of nuclear components using conventional probes, such as fluorescent dyes or proteins. Such probes provide weak signal and tend to rapidly photobleach (typically < 10 s), which limits both the temporal and spatial imaging resolution. An alternative is to use the bright probes such as quantum dots (QDs). However, to get such relatively large-sized probes into the nucleus requires overcoming the physical barriers of both the plasma membrane and the nuclear envelope without imposing unintended side effects.[2]