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The importance of the rapid administration of diazoxide in accelerated hypertension.

Abstract The effect of rapid (six to eight seconds) and slow (more than 10 minutes) infusions of diazoxide was compared in 15 hypertensive patients. In eight patients in the accelerated phase of hypertension the rate of administration of diazoxide influenced the degree and duration of antihypertensive response. After slow administration, there was no appreciable change in mean arterial pressure, whereas after the rapid administration, there was a 22 ± 8.9 per cent (± S.D.) average fall in mean arterial pressure lasting an average of 5.4 hours. In seven patients with chronic hypertension the rate of administration of diazoxide did not influence either the degree or the duration of hypotension. Since the status of the vascular disease influences antihypertensive drug response, characterization of the clinical status of the patient seems to be essential in any evaluation of antihypertensive drug response.