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A controlled study of single dosage cefamandole in the prophylaxis of wound infections in appendectomy.

A series of 102 consecutive patients undergoing appendectomy through an incision in the right iliac fossa entered a prospective randomized trial to compare the effects of a 2 gram intravenous bolus dose of cefamandole with a control study. No differences occurred in the incidence of wound infection in the two groups. We conclude that there is no place for a single preoperative dosage of cefamandole in the management of appendicitis.