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Distribution of pulmonary blood flow during the valsalva and Müller maneuvers.

During the Valsalva and Muller maneuvers, the effect of different levels of superatmospheric and subatmospheric alveolar pressures on the distribution of pulmonary perfusion was studied with the 133Xe method in 14 healthy subjects in the sitting position. Significantly increased unevenness was found to attend alveolar pressures of +20 and +40 mm Hg, whereas negative alveolar pressures (-5 to -40 mm Hg) resulted in significantly decreased unevenness of perfusion. The results are interpreted as due mainly to alterations in venous return.