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Exacerbation of Collagen Antibody–Induced Arthritis in Transgenic Mice Overexpressing Peroxiredoxin 6

Peroxiredoxin 6 plays important and complex roles in the process of inflammation, but its role in the development of rheumatoid arthritis (RA) remains unclear. We undertook this study to investigate the roles and mechanisms of peroxiredoxin 6 in the development of collagen antibody–induced arthritis (CAIA) and antigen‐induced arthritis (AIA) in peroxiredoxin 6–overexpressing transgenic mice, in peroxiredoxin 6–transfected RAW 264.7 cells, in macrophages isolated from peroxiredoxin 6–overexpressing transgenic mice, and in synoviocytes from arthritis patients.