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Stevens‐Johnson Syndrome, Respiratory Distress and Acute Renal Failure Due to Synergic Bleomycin‐Cisplatin Toxicity

A patient presenting with a cervix uteri epidermoid carcinoma had acute renal failure after treatment with cisplatin and bleomycin. She later developed fatal bleomycin‐induced pneumonitis and Stevens‐Johnson syndrome. This is a very rare association of adverse effects. The risk of causing a drug interaction thus increasing the severity of bleomycin undesired effects must be taken into account when a nephrotoxic drug is added to the former. The authors stress the importance of monitoring renal function under these conditions.