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Selective reduction of anti‐Helicobacter pylori IgG subclass antibody in gastric carcinoma

Background: Epidemiological studies have demonstrated strong links between Helicobacter pylori infection and gastric adenocarcinoma. Recent studies suggest that cell‐mediated immunity influences the outcome of infection, including the development of gastric adenocarcinoma. The T‐cell response can be characterized in terms of the secreted cytokine profile, which in turn influences the B‐cell response including the balance of IgG subclass antibody.