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Early bioavailability of paracetamol after oral or intravenous administration

Background:  Paracetamol is a peripherally acting analgesic commonly used in multimodal post‐operative pain management to reduce the need for more potent analgesics with their unwanted side‐effects. The dose and optimal galenical form for achieving analgesic concentrations is not well defined. The primary aim of this pilot project was to study the early bioavailability for two fixed doses of orally administrated paracetamol and one dose of intravenous propacetamol, all of which were given after minor surgery.