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Study on pinocytosis and antigen presentation by murine peritoneal macrophages to T cells in vitro after cisplatin treatment.

Macrophage monolayers showed significantly increased rate of pinocytosis on incubation with cisplatin (10 micrograms/ml). Further, the rate of pinocytosis was compared with macrophages treated with LPS (10 micrograms/ml). Cisplatin treated macrophages also showed enhanced capacity of antigen presentation to T cells in vitro. The antigen presenting capacity of cisplatin treated macrophages was compared with the antigen presenting capacity to LPS treated macrophages.