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Studies on New HL‐A Antigens of the First Segregant Series 1

Abstract. Population and family studies are reported showing that W 19 (equivalent designations: Li, LA‐W, Thompson, AO 28) belonging to the first segregant series, is heterogeneous and is probably composed of at least two and possibly four different specificities. One of them, designated as GE 33, is defined by two sera from multiparous women; another AO 28 is defined by serum THA from Amos and serum Thompson from Walford. Two additional specificities provisionally designated as LC 26.1 and LC 26.2 are less clearly defined by multispecific sera included in the last Histocompatibility Workshop. The existence of cross‐reactions between different HL‐A antigens of the same segregant series considerably complicates the accurate definition of new antigens. Other already known HL‐A antigens will probably have to be split into different ‘parts’, further increasing the already considerable polymorphism of the HL‐A system.