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Placental growth hormone variant: assay and clinical aspects

The human genome contains a family of five growth hormone (GH)/chorionic somatomammotrophin (CS) genes located in a 58 kbp cluster on the long arm of chromosome 17 (1, 2). Three of the five genes have been known for a long time to be expressed in the human pituitary (hGH-N) (3) or in the human placenta (hCS-A-B) (4), to yield human G H and human CS (also called placental lactogen). More recently, the product of hGH-V gene expression has been identified as placental G H (5-7).