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MUTAGENICITY OF MONOADDUCTS AND CROSS‐LINKS INDUCED IN ASPERGILLUS NIDULANS BY 8‐METHOXYPSORALEN PLUS 365 NM RADIATION

Abstract— 8‐Methoxypsoralen plus 365 nm radiation induces mutation at the methionine supressor loci of Aspergillus inhibitor‐deficient conidia at low doses of near‐UV radiation with one‐hit kinetics and at higher near‐UV radiation doses with two‐hit kinetics. These results and others suggest that both monoadducts and cross‐links, formed by 8‐methoxypsoralen and DNA upon exposure to UV radiation, are capable of inducing mutation. Evidence is also presented that induced furocoumarin cross‐links are responsible for the inactivation of the Aspergillus conidium.