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Effects of Medication and Deep Brain Stimulation on the Finger-tapping Speed and Amplitude of Parkinsonian Bradykinesia

Abstract: The purpose of this study is to investigate whether medication and deep brain stimulation (DBS) havedifferential effects on the speed and amplitude of bradykinesia in patients with Parkinson's disease (PD). Five PDpatients with implanted DBS electrodes (age: 60.6± 7.4 yrs, H&Y stage: 3.1± 0.2) participated in this study. FT (fin-ger tapping) movement was measured using a gyrosensor system in four treatment conditions: Med (Medication)-off/DBS-off, Med-off/DBS-on, Med-on/DBS-off and Med-on/DBS-on. Quantitative measures representing averagespeed and amplitude of FT movement included root-mean-squared (RMS) angular velocity and RMS angle. One-wayrepeated measures ANOVA showed that RMS angular velocity of Med-on/DBS-on was significantly greater thanthose of Med-off/DBS-off and Med-off/DBS-on (p 0.02). Effect size of RMSangular velocity was greater than that of RMS angle in both medication and DBS. This suggests that medication andDBS have differential effects on FT bradykinesia and velocity and amplitude impairments may be associated withdifferent functional aspects in PD.Key words: Parkinsonian bradykinesia, medication, DBS (deep brain stimulation), gyro sensor, angularvelocity, amplitude, finger-tapping