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A central anti‐DNA idiotype in human and murine systemic lupus erythematosus

The monoclonal anti‐DNA autoantibody A52 (IgG2b) was obtained from a (NZB × NZW)F1 (B/W) hybridoma. Two rabbits were immunized with the pure monoclonal antibody and produced anti‐idiotypic (Id) antibodies. The purified anti‐Id reacted with three different B/W monoclonal anti‐DNA antibodies at or close to their DNA binding sites. Moreover, the rabbit antibodies had a profound inhibitory effect on the polyclonal anti‐DNA activity in the majority of sera derived from B/W mice and human systemic lupus erythematosus (SLE) patients. The A52 IgG must, therefore, represent a major cross‐reactive Id of anti‐DNA immunoglobulins. In addition, the rabbit anti‐Id antibodies may act as the “internal image” of antigen and should prove useful in modulation of the autoimmune response to DNA in SLE.