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Luteinization and steroidogenic activity of rat ovarian follicles cultured in vitro.

Ovarian follicles were isolated from estrous rats and cultured in vitro for 1–6 days. After one day of culture there were no changes in the morphology of the follicles. In about 40% of the follicles cultured for 2 days, oocytes showed signs of degeneration. This was followed by the appearance of luteinized nests of cells in the theca and/or granulosa layers. On the 3rd day of culture all follicles had degenerated oocytes, and luteinization became more intense. Progestin was synthesized at a steady rate throughout the 3–day culture period. In contrast, estrogen was synthesized only from days 0–2 of incubation and showed a consistent decline on day 3 in all cultures. Very significant increases in progestin syntheses were obtained by the addition of 10 ng of LH to the culture medium. One hundred ng produced a significant but erratic increase in progestin syntheses. The addition of 10 ng of LH produced a minimal increase in estrogen synthesis while the 100 ng caused a very significant rise during days one and...