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Human polymorphonuclear leukocytes: effect of chloroquine on aggregation, arachidonic acid liberation and thromboxane B2 generation.

The effects of the antimalarial drug chloroquine (CQ) on arachidonic acid (AA) liberation from, thromboxane B2 (TXB2) formation in, and aggregation of isolated human polymorphonuclear (PMN) leukocytes stimulated with N-formyl-methionyl-leucyl-phenyl-alanine (FMLP) were investigated. CQ decreased aggregation of stimulated PMN leukocytes, however in contrast to AA liberation and TXB2 formation, lower concentrations were more effective than the highest one used. This effect may be associated with an increase in intracellular pH, reported to be induced by higher CQ concentrations, possibly counteracting the inhibition of aggregation, and/or eliminating negative feed back control of aggregation by lack of prostaglandins.