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Purification of a ribonuclease inhibitor from Novikoff hepatoma supernatant fraction.

A comparison between the levels of ribonuclease inhibitor in normal rat liver and Novikoff hepatoma 105,000 × g supernatant fractions is reported. Novikoff hepatoma contained 61% less inhibitor per g of tissue or 39% less per mg protein than did normal rat liver.

A rapid and simple method that had been developed for the purification of rat liver ribonuclease inhibitor was applied to Novikoff hepatoma 105,000 × g supernatant fraction. The purification procedure led to a 121-fold increase in specific activity, with a yield of 49%. The molecular weight and inhibition curve of purified inhibitor were also determined and were found to be similar to those of normal rat liver ribonuclease inhibitor.