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Distinct features of immunoglobulin G2 aquaporin‐4 antibody carriers with neuromyelitis optica

Neuromyelitis optica (NMO) is an inflammatory disease in which NMO‐immunoglobulin G (IgG) targeting aquaporin‐4 (AQP4) is specifically detected. Although the main subclass of AQP4 antibody was reported to be in the IgG1 subclass, other subclasses have also been described, including IgG2 AQP4 antibody, as a second common subclass. NMO patients were analyzed to clarify the clinical features of NMO patients with IgG2 AQP4 antibody.