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3D attitude control system for bio-micromanipulation

Bio-micromanipulation is important for biology and bio-engineering field. However, operation is very difficult, since the object is very small, kept in the liquid, and observed by the optical microscope. We have been developing a new 3D attitude control system for observation of the micro object such as an embryo, cell, and microbe. The image of the microscope is two-dimensional, so it is hard to observe the target in the 3-D space. To improve the work of the biological experiment, we proposed the 3-D bio-micromanipulation system combined with the virtual reality (VR) space. In this paper we propose the 3-D modeling method of the object to present the 3-D visual information to the operator and improved the observation environment. In this system, we still have difficulty to change the orientation of the microscopic object. The bio-aligner, we propose, is a micro device for the attitude control of an object. We develop a three-dimensional bio-aligner by microfabrication. We show its fabrication process and basic rotating experiment with yeast cells.