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Sonic hedgehog (Shh) processing is regulated by gastrin‐induced protease activity

In the mammalian adult stomach sonic hedgehog (Shh) is expressed in parietal cells. Gastrin, a gastric epithelial trophic factor, regulates acid production in the parietal cell. Gastrin‐deficient (G−/−) mice have impaired acid secretion and over time develop parietal cell atrophy that eventually results in gastric cancer. Since loss of Shh correlates with atrophic gastritis, the hypothesis that gastrin regulates Shh production within the parietal cell was tested.