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[RESEARCH PROGRESS OF NOVEL CROSS-LINKING METHODS APPLIED IN BIO-DERIVED MATERIALS].

OBJECTIVE
To review the research progress of novel cross-linking methods applied in bio-derived materials.


METHODS
The literature about the latest progress in the cross-linking methods of bio-derived materials was reviewed and analyzed.


RESULTS
The novel cross-linking methods of the bio-derived materials can be divided into chemical methods, physical methods, and biological methods, whose available application and cross-linking properties are greatly depended on their mechanisms. So proper methods should be developed to meet the various application requirements of the materials. A series of studies shows the feasibility and availability of the cross-linked bio-derived materials in the repair and reconstruction of the tissue.


CONCLUSION
Bio-derived materials modified by novel cross-linking methods are proved to obtain excellent biocompatibiity and tissue repair ability, better mechanical properties and degradation properties, and so on. Those methods provide researchers more choices to cross-linking materials, which are help to obtain the clinical tissue engineering products.