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S3 Identification of Patients at Risk for Pancreatic Cancer in a 3-Year Timeframe Based on Machine Learning Algorithms in the Electronic Health Record

when injected directly into the lesion and assess the impact on the lesion by means of imaging assessments every 3 months following first injection. Parkview Cancer Institute (Ft Wayne, IN) enrolled 13 of the 22 subjects in the second phase of the trial. Results: There were no safety concerns identified. Of the 13 subjects from Parkview, seven (54%) were restaged becoming eligible for surgery following LSAM pac injections. Of the seven, 6 proceeded to surgery, 1 opted to receive alternate treatment. Five resulted in successful R0 resections, the 6th resulted in R1 resection (Table 1). Multiplex immunofluorescence analysis of biopsy samples from pre-LSAM pac and surgical specimens in 5 subjects (one pending analysis) demonstrated an increase in the density of adaptive and innate immune cells and an increase in NK cells in the tumor microenvironment, and a decrease in the myeloid/ MDSC populations. Conclusion: Approximately 30% of pancreatic cancer patients are considered non-surgical due to involvement of local arterial or venous structures. Existing treatment options are relatively ineffective in producing changes in the tumor to allow for conversion, and surgery still provides the best outcome. We present early findings in a series of 13 subjects with a conversion rate of 54%. LSAM pac increased the rate of conversion to resectable in these subjects without increasing toxicities associated with systemic chemotherapy. Due to theses promising results, the clinical trial is ongoing, enrolling subjects to receive up to 4 injections one month apart.