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Violation of the balance of free metals and metal-containing proteins in amniotic fluid in placental insufficiency.

The content of metal ions and proteins containing or binding these metals in amniotic fluid during different periods of physiological pregnancy and placental insufficiency (PI) was studied. The content of zinc, copper, magnesium, iron, zinc-α-2-glycoprotein, ferritin, ceruloplasmin and the activity of Ca2+, Mg2+-ATPase were estimated using spectrophotometric methods, immunoturbometric and enzyme immunoassay methods. It was found that in PI in both trimesters there is a decrease in the content of zinc, copper, iron and an increase in the level of copper. The indices of ceruloplasmin, ferritin, Ca2+, Mg2+-ATPase in PI are lower, and zinc-α-2-glycoprotein is higher than in similar periods of physiological gestation. A close correlation of different directions has been established between the level of metals and the corresponding proteins. The revealed violations obviously play a certain pathogenetic role in the development of PI, and the indicators of the ratio between metals can serve as markers for predicting the state of newborns.