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Identification of a unique Staphylococcus aureus ribosomal signature in severe atopic dermatitis

An increased colonization by Staphylococcus aureus has been demonstrated in approximately 90% of atopic dermatitis (AD) patients and its prevalence on the skin increases with disease severity when examined using both culture-dependent and culture independent methodologies. Microbiome studies, targeting the gene encoding the bacterial 16S rRNA, have shown that microbial diversity is inversely correlated with disease stage in both adults and children, as well as the overall proportion of Staphylococcus spp in children. This trend is reversed with treatment. This article is protected by copyright. All rights reserved.