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Scanning Electron Microscopic Study on Red Blood Cells in Several Diseases of Newborns and Infants

Introduction The scanning electron microscope (SEM) has a resolution of 200A which is ten times that of the conventional light microscope, and presents a three-dimensional view of cells. The scanning electron micrograph of blood cells was first reported by Hayes et al. in 1966.1) Since then, several studies have been undertaken on the surface ultrastructure of normal and pathologic blood cells.2-8) Light microscopically, red blood cells are known to show biconcave disk and display morphological alterations under certain circumstances. It is obvious that the scanning electron microscopy enables more accurate morphological analysis of erythrocyte abnormalities than does the light microscopy. Only a few observations under SEM, however, have been carried on the abnormal erythrocytes in a variety of diseases. The present paper reports the scanning electron micrograph of abnormal red blood cells in several disorders of newborns and infants.