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Sodium and Potassium Chloride Preferences in Pyridoxine-Deficient Rats

Abstract Taste preferences for NaCl and KCl were studied in rats reared from weaning on pyridoxine-deficient or control diets. After 30 days on the diet, the deficient rats showed a markedly enhanced preference for KCl (80.1 vs 32.4%). But there was no significant increase in NaCl preference (85.9 vs 77.6%) which was already high in control rats. The increased KCl preference, along with previous reports of enhanced NaCl preference, reduced sodium secretion, and adrenal hypertrophy is suggestive of possible hyperaldo-steronism in pyridoxine deficiency.