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620 The Pattern of Neural Tube Defects in a Highly Endogamous Society: 25 Year Incidence Trends

Objective The aim of this study is to determine the incidence and trends of NTD over a period of 25 years in the State of Qatar. Design This is a retrospective hospital based cohort study. Setting The survey was carried out in the main territory hospital in the State of Qatar. Subjects and methods The study was conducted from 1985 to 2009 with a total of 302,049 newborns at the Women’s Hospital in Qatar screened for NTD. NTD were defined according to the International Classification of Diseases, Tenth Revision (ICD-10). Study parameters included age, gender, ethnicity, parental consanguinity, and residential area. Results The combined prevalence of NTD (total myelomeningocele and anencephaly) during the 25 years period was 1.09 per 1000 births. The prevalence of anencephaly was 0.36 per 1000 births. There were 131 (42.1%) males and 180 (57.9%) female newborns with NTD, corresponding to incidence of 0.899 and 1.289 per 1000 in male and female newborns, respectively. This difference was significant (p<0.001). Consanguinity was seen in 36.7% of the parents. Conclusion The present study revealed that Qatar has a relatively low incidence of NTD which is comparable to neighboring countries in the Arabian Gulf region. High rates of consanguinity and lack of periconceptual folic acid intake among mothers appear to be the major factors contributing to NTD in Qatar.