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A case control study to compare the levels of homocysteine in normal and complicated pregnancies

Aim: Hyperhomocysteinemia during pregnancy is known to cause endothelial dysfunction as a result of increased oxidative stress or direct toxic effects. The purpose of this study is to find the correlation between Hyperhomocysteinemia and various placental dysfunctional related pregnancy complications.
Materials and Methods: A prospective case control study of 100 women admitted in antenatal ward or Labour room of department of OBG was conducted at Shri B.M. Patil Medical College Hospital and research center Vijayapur. Study Group consisted of 70 pregnant women with different pregnancy complications like Pre eclampsia, Eclampsia, unexplained Abruption, FGR with oligohydramnios and unexplained oligohydramnios. Control Group was of 30 healthy pregnant women. Fasting Homocysteine level was checked in all participants.
Results: Mean level of Homocysteine was significantly raised in all patients with pregnancy complications (study group-26.4 umol/l) compared to patients without complications (control group - 8.4 µmol/L) with a p value of