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Simulated Ischemia Does Not Protect Against Efferent Sympathetic Denervation Following Acute Myocardial Infarction in Canine Hearts

Effect of Simulated Preconditioning on Neural Response During Ischemia. Introduction: Preconditioning the myocardium with brief episodes of ischemia preserves efferent autonomic responsiveness of noninfarcted myocardium apical to a site of acute transmural ischemia by mechanism(s) still unknown. We hypothesized that repeated brief exposure of the myocardium to a simulated ischemic milieu including hypoxia, high K. low pH, and adenosine would be as effective as brief coronary occlusions in creating this protection.