{'fraction_non_alphanumeric': 0.017517136329017517, 'fraction_numerical': 0.006854531607006854, 'mean_word_length': 4.918918918918919, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Cold promoted activation of factor VII. I. Evidence for the existence of an activator.

At the Institue for Thrombosis Research of the University of Oslo the author investigated the cold-induced thrombotest-time shortening which occurs in the plasmas of the majority of women on oral contraceptives or in the last trimester of pregnancy. Plasma was incubated overnight at 0-4 degrees. Clotting times for the cold-promoted activator (cold-promoted activating principle CPA) plasmas (plasmas with capacity for spontaneous generation of CPA after incubation at 0 degrees for 20 hours) after incubation were often less than half of the time for control samples (neither using drugs nor pregnant). The reaction in CPA plasma at 0 degrees had a lag time of 5-13 hours. Activation was revealed in both the extrinisic and intrinsic coagulation systems but the main activation was that of factor VII in the extrinsic system. Cooling and contact both promoted clotting in both the extrinsic and intrinsic systems. However cooling was the predominant promoter in the extrinsic system while contact was the prepominat promoter in the intrinsic system. Dilution experiments favored the idea than an activator rather than the absence of an inhibitor was responsible for the activation of factor VII in the incubated CPA plasma.