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PUTATIVE MEDIATOR ROLE OF ENDOTHELIN‐1 IN ASTHMA AND OTHER LUNG DISEASES

1. There is an increasing amount of research to implicate endothelin (ET)‐1, a member of a family of 21 amino acid peptides, as a potentially important mediator in pulmonary diseases, in particular asthma and pulmonary hypertension. Thus, ET‐1 fits several of the standard criteria that need to be fulfilled for a pathophysiologically relevant substance.