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Urine albumin level in mice infected with Trypanosoma brucei

Urine albumin levels were evaluated in mice infected with Trypanosoma brucei using urine strips (Medi-Test Combi 9, Macherey-Nagel, Neumann-Neander-Strabe 6-8, D-52355 Duren). The urine albumin level in some of the infected mice began to increase from the 6th day post-infection, and by the 12th day all infected mice showed a high level of albumin in urine which progressively increased with time. There was a high level of significance (F=161.9025, P<0.001) with mean urine albumin levels being significantly higher in trypanosome-infected mice (1.9302) than non-infected control mice (1.4771) As infection progressed there was also a significant increase (F=152721, P<0.001) with mean urine albumin levels increasing with time. It was concluded that urine albumin could be used to indicate trypanosomosis.