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Risk of hyperkalemia associated with selective COX‐2 inhibitors

Selective cyclooxygenase‐2 (COX‐2) inhibitors have been linked to cardiac death. The mechanism for this adverse effect appears to be by ischemic insult; however another mechanism could involve hyperkalemia. The objective of this study was to determine the effects of selective COX‐2 inhibitors and non‐selective nonsteroidal anti‐inflammatory drugs (NSAIDs) on serum potassium concentration and the electrocardiogram.