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Inhibitory Effects Of /spl beta/3 Integrin Antibody On The Migration Of Vascular Adventitial Fibroblasts Induced By Basic Fibroblast Growth Factor

14 Background and Purpose: Recent in vivo studies suggest that the adventitia, in addition to the media, may play an important role in restenosis afta balloon angioplasty [l-21. The mechanisms by which adventitial cells respond to injury and .contribute to intimal thickemng are however unknown. The 03 integrins are believed to play a key role in cell-matrix interactions [3]. The role of integrins in controlling cell migration is considered to involve the regulation of cell adhesion and intracellular signaling events triggered by various chemoattractants [4]. In this study we have investigated whether bFGF, a potent growth factor involved in vascular disease, can stimulate the migration vascular adventitial fibroblasts (VADFs), and whether an antibody to p3 integrin can inhibit bFGF-induced VADF migration.