{'fraction_non_alphanumeric': 0.038558256496227995, 'fraction_numerical': 0.025984911986588432, 'mean_word_length': 5.596685082872928, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Inflammatory and property effects of mitomycin C on the human medial rectus muscle

This study examined the effect of intraoperative mitomycin C (MMC) on adhesion reformation in human rectus muscles. Eight consecutive patients who underwent medial rectus recession had their post-operative rectus muscles divided into two groups: untreated (control) and treated with 0.02% MMC for 2 min, and were compared using three examination methods: histological analysis with hematoxylin-eosin staining to assess the inflammatory response and Masson's trichrome to semiquantify collagen fibrils, scanning electron microscopy analysis to quantify the diameter and D-periodicity of collagen fibrils, and atomic force microscopy analysis to quantify the diameter, D-periodicity and adhesion force of collagen fibrils. The rectus muscles treated with 0.02% MMC showed significantly increased inflammatory response (p &#60; 0.0001), increased fibril diameter (p &#60; 0.001 or p &#60; 0.05) and decreased fibril adhesion force (p &#60; 0.005) compared to controls. MMC may simultaneously cause an inflammatory response as well as nanostructural and mechanical property changes in the collagen fibril network.