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[Optimization of the preparation of 3',5'-dioctanoyl-5-fluoro-2'-deoxyuridine pharmacosomes using central composite design].

AIM
To optimize the preparation of 3', 5'-dioctanoyl-5-fluoro-2'-deoxyuridine pharmacosomes (DO-FUdR-PS) by using central composite design.


METHODS
DO-FUdR-PS was prepared by a thin-layer ultrasonication technique. The effects of drug phosphatidycholine ratio, pluronic F-68 concentration (%, w/v) and glycerol tristearate (%, w/v) concentration on the mean particle size, entrapment ratio (ER) and drug loading (DL) were investigated. A second-order polynomial equation was fitted to the data and the resulting model was used to predict the response in the optimal region.


RESULTS
All the investigated response variables were found to be highly dependent on the formulation variables. Under the optimized conditions, the mean particle size, ER and DL of DO-FUdR-PS were 76 nm, 97.49% and 31.44%, respectively, which highly agreed with the predicted values.


CONCLUSION
Central composite design was successfully used to optimize the preparation of DO-FUdR-PS.