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Stable xenon enhanced computed tomography in the study of clinical and pathologic correlates of focal ischemia in baboons.

When the lateral striate arteries of baboons are occluded, an immediate cessation of blood flow followed by a transient, minimal restitution of flow occurs in that vascular distribution. These findings are evident from serial xenon/computed tomography cerebral blood flow imaging. In our study, infarction consistently accompanied arterial occlusion for 6 hours or more. The xenon/computed tomography method provides a sensitive, noninvasive technique for examining sequential alterations of cerebral blood flow in small regions deep within the brain. This methodology for recording cerebral blood flow permits correlative studies of cerebral infarction, clinically and experimentally, and allows reasonable inferences about the probabilities of neural tissue damage.