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Ginger Constituents and its Effects on Gastrointestinal malignancies: A Review of clinical trials

Abstract   The gastrointestinal tract (GI tract) is the tract of the digestive system that contains all the major organs of the digestive system. Disorder in any part of the GI tract results in various disease forms such as malignancies. The occurrence of GI cancer is very high in developed countries including Europe. A wide variety of natural products containing anticancer properties showed significant effects. Ginger, the rhizome of Zingiber officinale, is among one of the natural herbal remedies widely used for its spice and medicinal properties. It is fair sources of vitamins like, β-carotene, vitamin C and minerals. Recently ginger has shown significant attention in clinical studies due to its anti-cancer effects that possesses promising potential for inhibiting the proliferation of multiple cancer cells. The aim of this review is to provide a summarized report of clinical trials on ginger constituents and its effects on gastrointestinal malignancies. A systematic search was conducted by two independent authors on the databases of Scopus, Clinical Trials, PubMed and Science with the search term of the key words. This review article supported that ginger is an important plant with several constituents and gastrointestinal medicinal effects. Ginger constituents suppress the growth and induce apoptosis of variety of cancer types including colon, gastric, pancreatic and other GI cancers. It is mainly the 6-gingerol and 6-shogaol, of the major compounds in ginger rhizomes, among hundreds of molecules. It is reported that antioxidant and anti-inflammatory properties of ginger support its preventive role against the gastrointestinal malignancies. Key messages • This review article provided evidences supporting the effects of ginger on gastrointestinal malignancies and demonstrates the importance of future studies. • Therefore, more extensive and well-controlled clinical trial studies of ginger are required to demonstrate its effect on gastrointestinal malignancies.

The gastrointestinal tract (GI tract) is the tract of the digestive system that contains all the major organs of the digestive system. Disorder in any part of the GI tract results in various disease forms such as malignancies. The occurrence of GI cancer is very high in developed countries including Europe. A wide variety of natural products containing anticancer properties showed significant effects. Ginger, the rhizome of Zingiber officinale, is among one of the natural herbal remedies widely used for its spice and medicinal properties. It is fair sources of vitamins like, b-carotene, vitamin C and minerals. Recently ginger has shown significant attention in clinical studies due to its anti-cancer effects that possesses promising potential for inhibiting the proliferation of multiple cancer cells. The aim of this review is to provide a summarized report of clinical trials on ginger constituents and its effects on gastrointestinal malignancies. A systematic search was conducted by two independent authors on the databases of Scopus, Clinical Trials, PubMed and Science with the search term of the key words. This review article supported that ginger is an important plant with several constituents and gastrointestinal medicinal effects. Ginger constituents suppress the growth and induce apoptosis of variety of cancer types including colon, gastric, pancreatic and other GI cancers. It is mainly the 6gingerol and 6-shogaol, of the major compounds in ginger rhizomes, among hundreds of molecules. It is reported that antioxidant and anti-inflammatory properties of ginger support its preventive role against the gastrointestinal malignancies.

Key messages:
This review article provided evidences supporting the effects of ginger on gastrointestinal malignancies and demonstrates the importance of future studies. Therefore, more extensive and well-controlled clinical trial studies of ginger are required to demonstrate its effect on gastrointestinal malignancies.

Background:
Substitutes for meats and sausages are growing both in demand and supply in Germany. Monitoring their nutritional composition helps characterise this novel product group in terms of its dietary contribution.

Methods:
Data on substitutes for meats and sausages were collected in a baseline survey in 2016 and an in-depth follow-up survey in 2021. In both surveys, mandatory nutrition declaration (''Big 7'') and other packaging information were collected via online research and supermarket visits. Products were categorised according to the substituted animal products and their contents of energy, fat, saturated fatty acids, and salt investigated. Changes in energy and nutrient contents between baseline and follow-up survey were assessed statistically using Welch's t-test.

Results:
The follow-up survey included 421 meat substitutes and 292 sausage substitutes, split into 27 subgroups. Substitutes for meat products like meat strips and schnitzel show widely varying energy contents. Sausage substitutes show higher medians for fat, saturated fatty acids and salt than meat substitutes; spans of salt content (0,1-4,0 g per 100 g product) and saturated fatty acids (0,1 g -23,0 g per 100 g product) are particularly wide. Relative to the baseline survey, which included 69 meat substitutes and 61 sausage substitutes, the follow-up revealed significantly higher contents of energy and saturated fatty acids overall and in some subgroups (e.g. nuggets and burger patties). The sole significant reduction was seen for energy in substitutes of precooked sausages.

Conclusions:
The observed wide spans of energy and nutrient content imply 1) the potential to reformulate substitutes for meats and sausages at the top end of the spectrum 2) the availability of healthier choices within the various subgroups. The increases shown in energy and saturated fatty acids content warrant further monitoring. Key messages: Wide spans of energy and nutrient contents reveal the potential for the development of more nutritionally favourable substitutes for meats and sausages. As substitutes for meats and sausages are perceived to have nutritional advantages the observed increases in energy and saturated fatty acids contents over time should be further monitored.
15th European Public Health Conference 2022 iii507