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lnterleukin-3 and Granulocyte-Macrophage Colony-Stimulating Factor Receptor Signal Transduction

Abstract The cytokines, interleukin-3 (IL-3) and granulocyte-macrophage colony-stimulating factor (GM-CSF), share many similar activities on cells of the hemopoietic system. Cloning of the receptors for IL-3 and GM-CSF revealed that these two cytokines utilize receptors consisting of a ligand-specific α unit and a β subunit which is shared. Neither subunit contains intrinsic tyrosine kinase activity, but deletion analysis of the β subunit cytoplasmic domain has defined certain regions which are important for signal transduction.