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[Results of the cytogenetic prenatal diagnosis in the first and second trimesters of pregnancy].

The authors analyze the results of prenatal diagnosis carried out in women during the first and second pregnancy trimesters. Cytogenetic screening was carried out in risk-group pregnant women, i.e. in women aged over 36, in cases with family history of chromosome mutation or a previous child with chromosome aberration, or a sex-linked disease in one of family members, etc. Chromosome preparations from amniotic fluid cell cultures and 'direct' chromosome preparations from chorionic villi were analyzed. The authors discuss the efficacy of prenatal diagnosis in various pregnancy periods, fetal tissue collection methods and quantities necessary for the examination.