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Clinical significance of fatal laryngeal stridor in fatal familial insomnia

Fatal familial insomnia (FFI) is characterized by numerous signs and symptoms, including progressive insomnia; dysautonomia and endocrine disturbances; and motor disturbances such as myoclonus, ataxia, parkinsonism, spasticity, dysarthria, and dysphagia. Mental health and behavioral changes include impaired concentration and memory, as well as confusion and hallucinations. FFI patients frequently die due to secondary infections and sudden insomnia‐induced death. To date, laryngeal stridor has not been fully investigated in FFI patients.