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230 GENETIC INFLUENCES ON PANCREAS TRANSPLANTATION

The susceptibility of mice to develop experimental diabetes vary among different inbred strains. 6J mice are more resistant to develop diabetes than KsJ mice due to the ability of their islet cells to undergo hypertrophy. These differences may manifest also during transplantation. Twelve 6J mice were made diabetic with streptozotocin given at 1 mg per gm body weight and 12 KsJ mice with 0.5 mg per gm. A week later islet cells from 6 week old normal 6J and KsJ mice were transplanted into the kidney capsule of the diabetic mice. Pancreas tissue from two normal 6J and two KsJ mice were minced with scissors into fragments about 0.5 to 1 mm in Hank's solution and immediately transferred into the renal capsule of the 6J and KsJ diabetic host respectively. The course of the diabetes was followed by determination of plasma glucose. The pre transplantation mean ±SD glucose was 524±119 in 6J and 529±76 mg/per 100 ml in KsJ, and the post transplantation was 263±134 in 6J and 426±135 mg/per 100 ml in KsJ. Islets containing beta cells were stained with aldehyde fuchsin and found to be present in higher numbers in 6J than in KsJ mice. The significantly higher recovery from hyperglycemia in 6J mice than in KsJ mice suggests a genetic influence in the ability of transplanted islet cells to reverse diabetes.