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DOPAMINERGIC AND CHOLINERGIC MODULATION IN A BIOPHYSICAL MODEL OF THE NEOSTRIATUM

Department of Cognitive Science University of California San Diego, La Jolla, California 92037 ABSTRACT Although interaction between dopaminergic and cholinergic modulation is clearly important for normal striatal function, the precise mechanism of this interaction is far from clear. This paper describes a biophysical model of the neostriatum which includes models of dopaminer gic and cholinergic influences at the level of individual ion channels. The model makes implicit claims about the effects of these interactions on phenomena from the firing of single neurons, and the behavior of small networks of such neurons, on up to system phenomena such as shortterm memory.