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Detecting treatment effects with combinations of the ADAS‐cog items in patients with mild and moderate Alzheimer's disease

When complex cognitive functions are measured with multi‐item scales like the Alzheimer's Disease Assessment Scale – cognitive subscale (ADAS‐cog), it seems valuable information can be lost due to combination of the ADAS‐cog items results into a total score. We hypothesized, that an analysis of the results of different ADAS‐cog item combinations may reveal drug treatment effects in distinct cognitive domains and/or enhance the sensitivity to detect such treatment effects. Here, we present a novel approach called ‘subsetting analysis’ for assessment of drug treatment effects with multi‐item scales, like the ADAS‐cog.