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Evaluation of an automated serologic test for syphilis.

Physicians are requesting decreasing numbers of serologic tests for syphilis for hospitalized patients. The possibility of performing a larger volume of serologic tests for syphilis for screening purposes easily and economically led to a comparison of the automated reagin test and the VDRL slide test. Five thousand sera were tested by both methods. Half the specimens were from patients for whom serologic tests for syphilis had been ordered and the other half from patients for whom such tests had not been requested. The incidence of reactives was greater among the patients for whom tests had been ordered, although two cases of latent syphilis were discovered and treated in the latter group. The two tests had comparable sensitivity and specificity. The automated procedure is easier to perform. The convenience of interpretation of results and lesser technical skill required for performance of the tests were considered advantageous for laboratories performing a hundred or more serologic tests for syphilis daily.