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CYTOTOXIC AND APOPTOTIC EFFECTS OF NOVEL SYNTHESIZED FERULIC ACID DERIVATIVES ON MYELOGENOUS LEUKEMIA CELL LINE

Ferulic acid (FA), or 4-hydroxy-3-methoxycinnamic acid, is a phenolic compound that can be used in many pharmacological applications, especially in the area of cancer. In this study, four new FA-quinoline esters were successfully synthesized and characterized using 1 H-NMR, 13 C-NMR, HR-Mass, Elemental Analysis, and FT-IR techniques. Synthesized compounds were tested on leukemia cell lines (HL-60 and K562) with WST-1 assay and Annexin V-PI assay via flow cytometry. The WST-1 assay of compounds in HL-60 and K562 leukemia cells yielded IC50 124.4 and 205.4 μM/mL, respectively. According to the results, both the cytotoxic effect and apoptotic effects of 2c increased on HL-60 cell.