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Protection Anticonvulsant effect of Irbesartan in Lidocaine
Induced Seizure in Mice

Background: Epilepsy is one of the most common serious brain disorders and may have many possible causes due to many different cellulars or biochemical changes such as alterations in ion channels function, neurotransmitter level, neurotransmitter receptor function, energy metabolism, and oxidative stress. The chronic and intermittent nature of epilepsy and the inability of the current drugs to sustain long term remission made a continuous need to investigate a new drug that aims to minimize the morbidity and to improve the quality of patient life. Aim of the study: To investigate protection anticonvulsant effects of irbesartan in lidocaine induced Seizures in male mice. Methods: A total of 40 albino male mice were equally divided into four groups. The blank group was given vehicles only. The model of seizure was induced by a single intraperitoneal injection of Lidocaine (75 mg/kg). Irbesartan group was pretreated intraperitoneally (20 mg/kg) for 7 days and lidocaine injection on the 8th day as an acute induction, and the same was applied to the diazepam group (2 mg/kg) which served as a positive control. On the 8th day, the level of N-methyl-D-aspartate receptor (NMDA-R) and caspase-3 were measured. Furthermore, the body weights were daily documented before each administration. Results: The results revealed a highly comparable significant reduction in NMDA-R and Caspase-3 in both irbesartan and diazepam groups, also both modestly decreased in potency and duration of the seizure. Conclusion: Irbesartan significantly reduces NMDA-receptor and Caspase-3 in lidocaine induced seizure in mice model and decrease the potency and duration of the seizure.