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[Systemic mechanisms of nervous disorders].

Apart from the lesion and destruction of nervous structures and nervous links there is a different, so far little known, aspect of pathogenesis of nervous disorders, i.e. appearance of new pathological integrations in the nervous system. Formation and activity of these integrations is realized by endogenous, intrinsic to the damaged nervous system itself mechanisms. Pathologic integration occurring at the level of systemic relations is a pathologic system. The main biological sign of a pathologic system, due to which it differs from a physiologic system, is a dysadaptive or directly pathogenic significance of its activity for the organism. The pathologic system may be originate as a result of hyperactivation and loss of control over the physiologic system or due to the formation of a new, pathodynamic organization in the central nervous system. The neuropathological syndrome is clinical expression of the corresponding pathologic system activity. Every syndrome has its pathologic system and the specificity of the syndrome depends on what structures of the central nervous system are part of the pathologic system. Simple, linear pathologic systems underlie the monomorphic syndromes and symptoms, and complex ones underlie the polymorphic syndromes. Due to plasticity the positive connections between the parts of the pathologic system are consolidated therefore with course of time the resistance of the pathologic system to the endogenous sanogenetic mechanisms and to therapy increases. Stabilization of pathologic system underlies the chronization of nervous disorders. The concept of the pathologic system as a basic pathophysiological mechanism of nervous disorders is a new approach to understanding pathogenesis, elaboration of models and development of new principles and method of treatment of nervous disorders.