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The inactivation of prostaglandin E2 and 5-hydroxytryptamine in isolated perfused fetal and neonatal rabbit lungs.

The inactivation of prostaglandin E2(PGE2) and 5-hydroxytryptamine (5-HT) was studied in isolated perfused lungs from fetal and neonatal rabbits. PGE2 inactivation was considerable already at the 28th day of fetal life, as only 11% of injected substrate survived passage through the pulmonary circulation. However, the inactivation increased significantly during the last 3 prenatal days (4% survival) and remained at this level when analyzed one week postnatally. In contrast to PGE2-metabolism, 5-HT inactivation was relatively stable during the studied fetal period (47-49% inactivation), but was decreased significantly on the 7th day postnatally when compared to newborn litters. The results indicate that pulmonary prostaglandin and amine metabolism reach maturity at different times during the perinatal period.