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A Hamster Fibrohemangiosarcoma: Influence of Host Sex on Tumor Mass 1

Summary A fibrohemangiosarcoma was produced in hamsters following the injection of cell inocula. These tumors in pregnant, lactating female hamsters attained a wet tumor weight 4-8 times greater than that noted in either adult male or female hamsters within 6-7 wk. Monolayer cell cultures obtained from a fibroma produced by the injection of cells from a Wistar Institute HE-44 culture in its 69th passage was alternately repassaged through inbred Syrian hamsters. Following the fourth animal repassage a culture line was obtained which consistently through the 16th subculture produced tumors composed of spindle cells, endothelial cells and cells intermediate between these two types of cells. It is considered likely that the culture line consisted of mesenchymal cells that have retained some degree of pluripotentiality. Strong acid phosphatase, β-glucuronidase and nonspecific esterase activity was present in the cells of the tumor tissue as well as in the cells grown in culture for 16 passages. It is probable that hormonal influences associated with growth are responsible for the observed differences in wet tumor weight in pregnant and nonpregnant hamsters. This tumor showed histologic resemblance to the human Kaposi sarcoma.