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A Novel Approach in Allergen-Specific Immunotherapy: Combination of Sublingual and Subcutaneous Route

S Keles, E Karakos-Aydiner, A Ozen. J Allergy Clin Immunol. 2011;128(4):808–815

To compare the efficacy and safety of a novel combination of subcutaneous immunotherapy (SCIT) for induction and sublingual immunotherapy (SLIT) for maintenance, to immunotherapy via a single method (either SCIT or SLIT) for both induction and maintenance.

Investigators enrolled 60 children, aged 5 to 12 years, monosensitized to house dust mite (HDM), who had been followed at a pediatric allergy immunology clinic in Istanbul for mild persistent to moderate asthma or rhinitis, with persistent symptoms despite inhaled or intranasal steroids for 2 years.

After an 8-week evaluation to assess baseline symptoms, patients were randomized to 1 of 4 parallel treatment groups. One group was treated with pharmacotherapy, while the other 3 received immunotherapy administered in 1 of …