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A longitudinal study of cerebrospinal fluid beta‐endorphin‐like immunoreactivity in delirium: changes at the acute stage and at one‐year follow‐up

Cerebrospinal fluid beta‐endorphin‐like immunoreactivity (CSF BLI) was determined on 3 occasions for elderly delirious patients and the BLI levels were compared with age‐equivalent controls. Delirious patients showed a significant reduction in the BLI values in the first sample and a declining trend was seen in the follow‐up. The results suggest a role for beta‐endorphinergic dysfunction in the genesis of some symptoms of delirium, and this dysfunction may be a common phenomenon in various forms of delirium and dementia.