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Estimation of the correlation serum resistin with metabolic syndrome

Adipose tissue-derived adipokines play important role in metabolic syndrome and obesity related disease. Although the molecular mechanisms for this are less understood. In this study, we determined serum resistin in relation to metabolic syndrome determinants. For this purpose, Fasting blood samples were collected from brachial vein in 39 sedentary adult overweight - obese men aged 35 – 43 years in body mass index (BMI) ranged 28 to 33 kg/m2 in order to measuring serum resistin, lipid profile and glucose concentration. Anthropometrical indexes and blood pressure were also measured in all participants. Pearson rank correlation analysis were used for determine relationship between resistin with metabolic syndrome determinants. A p-value less than 0.05 were considered statistically significant. Serum resistin levels correlated positively with BMI, body fat percentage (BF%), Total cholesterol (TC), low density lipoprotein (LDL), age, visceral fat, waist to hip ratio (WHO), systolic and diastolic blood pressure in studied subjects. A borderline signigcant positive association was observed between serum resistin and glucose concentration. Resistin as an inflammation cytokine is associated with metabolic syndrome in obese subjects.