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New biomaterials for keratoprostheses

Purpose Although a wide range of keratoprostheses have been developed from various materials over the last 30 years there has been limited optimisation of material properties to enhance clinical performance and minimise tissue incompatibility within the ocular environment. The development of our understanding of the biological interactions between materials and corneal tissues, the failure of existing keratoprostheses, the advances in the design and synthesis of materials of controlled molecular architectures and the advancements in composite biomaterials in recent years provides an opportunity to design enhanced biomaterials for the fabrication of the next generation of keratoprosthetic with improved clinical performance.