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Dual FAAH and MAGL inhibition might play a key role in visceral pain.

Evaluating and managing any patient with chronic abdominal pain are challenging. Drugs such as nonsteroidal anti-inflammatory drugs, opioids, anti-depressants, and anticonvulsants are clinically used in the treatment of pain (2). Cannabis has been traditionally used to treat gastrointestinal diseases, including abdominal pain, for centuries, and its mechanism has been understood within the past two decades after identification of the endocannabinoid system (ECS) and cannabinoid receptors (CB1 and CB2) (3).