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Temporary alteration of cerebrovascular permeability to plasma protein during drug-induced seizures.

LORENZO, A. V., I. SHIRAHIGE, M. LIANG, AND C. F. BARLOW. Temporary alteration of cerebrovascular permeability to plasma protein during drug-induced seizures. Am. J. Physiol. 223(2): 268-277. 1972.-The blood-brain barrier normally restricts the entry of plasma proteins into the central nervous system. Regional increases in the penetration of albumin-1251’ into brain were observed in paralyzed, artificially respired animals convulsed for 5, 15, 30, and 60 min with pentylenetetrazol. In the thalamus, the increase was directly proportional to duration of the seizure and did not appear to be dependent on blood flow or vasodilatation but to an enhanced vascular permeability. A cholinergic mechanism may be implicated as pretreatment with methantheline, a cholinergic antagonist, significantly reduced the permeability change. The alteration in vascular permeability was reversible, as indicated by the rapid decline in thalamic albumin-1251 activity minutes after seizure arrest. While metabolic degradation of albumin-l251 in brain accounted for an appreciable portion of the decline, the evidence suggested that a significant amount of the albumin-l251 returned to blood.