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A double-blind cross-over trial of trimethoprim and sulphamethoxazole in chronic bronchitis

A double-blind cross-over trial comparing trimethoprim-sulphamethoxazole with sulphamethoxazole in patients with chronic bronchitis in their usual state of health showed that the combination was more effective in reducing the volume and purulence of the sputum. Although the patients preferred treatment with the combination, there was no objective improvement in respiratory function. There was a significant incidence of side effects.