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Inhibition of nitric oxide synthesis by aminoguanidine increases intestinal damage in the acute phase of rat TNB‐colitis

The role of nitric oxide (NO) in the pathophysiology of inflammatory bowel diseases (IBD) is controversially discussed. The aim of the present study was to investigate the role of NO inhibition in the acute phase of rat 2,4,6‐trinitrobenzenesulphonic acid (TNB)‐colitis. To inhibit NO synthesis we used aminoguanidine (AG) as a selective inhibitor of inducible nitric oxide synthase (iNOS).