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Lack of Soluble TNF‐receptors in Women with Recurrent Spontaneous Abortion and Possibility for its Correction

Tumor necrosis factor (TNF) and soluble TNF receptors (sTNF‐Rs) system related with Th1 and Th2 and activity of NF‐κB/IκB regulatory system. This study was designed to compare sTNF‐R1 and sTNF‐R2 production (shedding) and levels of late activated CD8+ T‐lymphocytes in non‐pregnant (n = 30) and pregnant (n = 20) normal women and non‐pregnant (n = 20) and pregnant (n = 30) RSA women. Effects of progesterone (natural structure) injections in RSA women were studied.