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Feminizing Gonadal Stromal Tumors: Analysis of the Granulosa-Theca Cell Tumors of the Ovarian Tumor Registry

A study of the last 1800 specimens from the Ovarian Tumor Registry (OTR) has yielded 307 granulosa-theca cell (feminizing gonadal stromal) tumors. These have been reveiwed in regard to predominant cell type (granulosa or theca), age, symptomatology and salvage. There was a high incidence of endometrial stimulation (23% adenocarcinoma and 65% hyperplasia), but this may be misleading since only unusual specimens are referred to the OTR. Five-year survival of 184 traceable patients was 78%. This survey, combined with a previous study from the OTR by Busby and Anderson, comprises a five-year follow up of 280 of 414 patients (among 2,300 OTR patients) with a salvage rate of 78.5%, although pure thecomatous tumors will show a better than 90% salvage.