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A comparative analysis of autologous conditioned serum (ACS) & platelet‐rich plasma (PRP) in early osteoarthrosis of knee

Osteoarthrosis represents a failure of the diarthrodial, synovial lined joint. Among the elderly, knee osteoarthrosis is the most frequent cause of chronic disability. The prevalence of osteoarthrosis is rising in the Indian population because of the increased life span. Platelet rich plasma (PRP) is defined as a volume of plasma with a platelet concentration more than that in the peripheral blood. Many basic, preclinical and even clinical case studies and trails report PRP’s efficacy to improve musculoskeletal conditions including osteoarthrosis. Autologous conditioned serum (ACS) is an autologous blood product eNRIched with interleukin-1 receptor antagonist (il-1ra), a naturally occurring inhibitor of interleukin-1 (il-1). Our study on ACS & platelet rich plasma has thrown up an exciting choice of treatment modality in knee osteoarthrosis, and it has proved efficient in observation period of two years.