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Hepatoprotective Activity of Licorice in Rat Liver Injury Models

ABSTRACT The hepatoprolective activity of a water extract of Glycyrrhiza glabra L. was studied against CCI4 induced, acute hepatotoxicity in rats. Liver damage was assessed by estimating serum enzyme activities of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, total protein, albumin, globulin, and A/G ratio. Pre- and post-treatment with licorice extract showed a dose-dependent reduction of CCI4-induced elevated serum levels of enzyme activity with parallel increase in total protein and albumin levels, indicating the licorice could preserve the normal functional status of the liver.