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Functional and Metabolic Studies of Platelets from Patients with Lesch‐Nyhan Syndrome

Platelet function was investigated in three patients with the Lesch‐Nyhan syndrome. Platelet count, morphology and size distribution was normal in all patients. Platelet turnover was normal. Electron microscopy did not reveal any ultrastructural abnormality. Template bleeding times were normal and prolonged after aspirin ingestion in two out of the three patients: the patient that failed to respond to the aspirin challenge also had decreased retention of platelets on a glass bead column.