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Effect of anti‐Lyb3 antiserum on poly (L‐glutamic acid, L‐lysine)‐induced B cell tolerance

The effect of anti‐Lyb3 antiserum on antigen‐specific B cell tolerance was investigated. The intraperitoneal injection of the nonimmunogenic copolymer L‐glutamic acid60, L‐lysine40 (GL) specifically reduces the ability of murine B cells to form GL‐specific plaque‐forming cell responses following challenge with the immunogenic conjugate of GL coupled to fowl gamma‐globulin. It was found that this tolerance could be reversed or blocked by the intravenous injection of microliter quantities of anti‐Lyb3 antiserum. However, this dose of antiserum neither reversed T cell tolerance induced with protein‐coupled syngeneic erythrocytes nor induced tolerized B cells to secrete antibody. The results suggest that B lymphocytes can be rescued from GL‐induced tolerance soon after induction and that Lyb3 determinants may play a functional role in the activation of antigen‐specific B lymphocytes.