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47 STRUCTURAL POSITION AND AMOUNT OF PALMITIC ACID IN INFANT FORMULAS: EFFECTS ON FAT AND MINERAL BALANCE

The effect of the structural position and amount of palmitic acid on fat absorption and mineral balances were investigated in three groups of each 9 healthy term infants. Three formulas were compared: (a) formula 1, resembling most closely the structure of human milk fat (23% palmitic acid; 69% esterified at sn-2 position); (b) formula 2, an intermediate type of formula (23% palmitic acid; 39% esterified at sn-2 position); (c) formula 3, a currently marketed control formula (18% palmitic acid; 11% esterified at sn-2 position). The total amount of sn-2 palmitate was higher in formula 2 than in formula 3, while the amount of sn-1,3 was similar in these two feedings. The infants were randomly assigned to receive one of the three infant formulas exclusively from birth until at least five weeks of life. Seventy-two hour macronutrient and mineral balances were performed during the fifth week.A formula containing palmitic acid predominantly al the sn-2 position has significant beneficial effects on the intestinal absorption of fat and improves calcium balance in healthy term infants.