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Angiography of multiple asynchronously manifest pheochromocytomas: the APUD concept.

The APUD (amine precursor uptake and decarboxylation) concept [1] is a currently favored explanation for multiple primary pheochromocytoma. We discuss the relevance of this concept and report the angiographic demonstration of at least a dozen discrete tumors in a girl who was first seen with an extraadrenal pheochromocytoma. Two of the metastases showed angiographic appearances indistinguishable from the primary tumors.