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Effect of nonionic surfactant on bactericidal activity of cetylpyridinium chloride.

The interaction of cetylpyridinium chloride with a nonionic surfactant was examined by equilibrium dialysis; and by using the simple aqueous phase saturation model, the effect of the surfactant upon the biological activity of the bactericide was predicted. Determination of the degree of reduction of bactericidal activity showed good agreement with the predicted result over a concentration range of 10-100 p.p.m. of bactericide. Below a concentration of 10 p.p.m., a discrepancy between the predicted and experimental results was possible.